AU2017336160A1 - Screening methods using olfactory receptors and novel compounds identified using the same - Google Patents

Abstract

The presently disclosed subject matter relates to methods of screening raw materials and pet food products to manufacture a palatable pet food product. The presently disclosed subject matter also relates to methods for identifying compounds that modulate the activity and/or expression of an olfactory receptor.

Description

SCREENING METHODS USING OLFACTORY RECEPTORS AND NOVEL COMPOUNDS IDENTIFIED USING THE SAME

CROSS-REFERENCE TO RELATED APPLICATION

This application claims priority to U.S. Provisional Application No.: 62/402,823 filed on September 30, 2016, the content of which is incorporated by reference in its entirety, and to which priority is claimed.

SEQUENCE LISTING

The application contains a Sequence Listing which has been filed electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on September 7, 2017, is named 069269__0225 SL.txt and is 7,123,619 bytes in size.

FIELD

The presently disclosed subject matter relates to the use of olfactory receptors (ORs) for the identification of olfactory modulators. The presently disclosed subject matter further relates to the use of olfactory receptors to screen raw materials for making pet food products, as well as screening finished pet food products, for the presence of olfactory modulating compounds.

BACKGROUND

Olfactory profiles for edible compositions can be characterized by a set of psychophysical descriptors, such as, for example, one or more of a fruity, floral, honey, fatty, minty and metallic smell. In certain embodiments, a combination of different odorants can be perceived as a new odor object. Chemical compounds that elicit these odor senses are often referred to as odorants. Without being bound by theory, it is hypothesized that odors are sensed by olfactory receptors in the nasal cavity and throat which transmit signals to the brain where the odorants and resulting olfactory profiles are registered. Olfactory receptors comprise a large class of G-protein coupled receptors (GPCR) that detect compounds associated with odor sensory perception.

Pet food manufacturers have a long-standing desire to provide pet food products that have high nutritional value. In addition, and with particular regard to cat and dog foods, pet food manufacturers desire a high degree of palatability so that pets can receive

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PCT/US2017/054620 the full nutritional benefit from their food. Domestic animals are notoriously finicky in their food preferences, and often refuse to eat a pet food product that it has accepted over time or refuse to eat any more than a minimal amount of a pet food product. This phenomenon may be, in part, due to the subtle differences in the sensory profiles of the raw material, which can be perceived by the domestic animals because of their gustatory and olfactory systems. As a result, pet owners frequently change types and brands of pet food in order to maintain their pets in a healthy and contented condition.

While there have been recent advances in odor and flavor technologies, there remains a need for methods of screening raw materials that are used to make pet food product, and for screening finished pet food products, to ensure that the most palatable products and processes for making the pet food products are used. There also remains a need for compounds that can enhance or modify the palatability of pet food products by enhancing or modifying the odor, texture and/or flavor profiles of the pet food products. The enhancement or modification can be used to increase the intensity of a desirable attribute, to replace a desirable attribute that is not present or somehow lost in the pet food product, or to decrease the intensity of an undesirable attribute. In particular, it is desirable to decrease the presence or intensity of undesirable repellant odors in a pet food product. Similarly, there is a need to increase the acceptance of pet medications by enhancing or modifying the palatability of the medications.

The pet care industry is also concerned with developing odor deterrents that can effectively discourage a pet from scratching, chewing, licking, or ingesting things that harm the health of the animal or the property of the owners. While it is known that certain odorants can be effective to deter pets, there is a significant variation in pets’ reactions to these odor deterrents. Thus, there exists a need for compounds that effectively impart an undesirable odor to hannful or toxic objects.

Therefore, there remains a need in the art for methods to screen raw pet food materials (e.g. new protein sources), as well as final pet food products, to provide fragrant, palatable and nutritious pet food. There also remains a need to identify compounds that enhance, decrease, or otherwise modulate the palatability and/or deterrence of pet food products, or objects, and for odor compositions comprising these compounds.

SUMMARY OF THE INVENTION

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The presently disclosed subject matter provides methods for identifying compounds that enhance, increase, decrease and/or modulate the activity and/or expression of an olfactory receptor. In certain embodiments, the methods entail screening for compounds that modulate the olfactory receptor activity and/or expression in a pet food product or medicine, or in raw materials used to make the pet food product or medicine. The presently disclosed subject matter also provides compounds that enhance, increase, decrease and/or modulate the activity and/or expression of an olfactory receptor identified by said methods, in certain embodiments, the olfactory receptor is a canine or feline receptor.

In certain embodiments, the method for identifying compounds that enhance, increase, decrease and/or modulate the activity and/or expression of an olfactory receptor comprises expressing an olfactory receptor having a nucleotide sequence set forth in any one or more of SEQ ID NOs: 11-30, or any one or more of the nucleotide sequences set forth in SEQ ID NOs:61 -3808, or a fragment or variant thereof, in a cell. The method can further comprise contacting the cell expressing the olfactory receptor with a sample (e.g., pet food raw material, finished pet food, or a test compound) and determining the activity and/or expression of the olfactory receptor in the presence of the sample as compared to the activity and/or expression of the receptor in the absence of the sample.

In certain embodiments, the activity and/or expression of the olfactory receptor is detennined in the presence of the sample and an olfactory receptor agonist.

In certain embodiments, a method for identifying compounds that enhance, increase, decrease and/or modulate the activity and/or expression of an olfactory receptor comprises expressing an olfactory receptor having an amino acid sequence set forth in any one or more of SEQ ID NOs:41-60, or any one or more of amino acid sequence set forth in SEQ ID NOs:61-3808, or a fragment or variant thereof, in a cell. The method can further comprise contacting the cell expressing the olfactory receptor with a sample (e.g., pet food raw material, finished pet food, or a test compound) and determining the activity and/or expression of the olfactory receptor in the presence of the sample as compared to the activity and/or expression of the receptor in the absence of the sample.

In certain embodiments, the activity and/or expression of the olfactory receptor is determined in the presence of the sample and an olfactory receptor agonist.

In certain embodiments, the present disclosure provides a method for identifying a composition that modulates the activity of an olfactory receptor comprising (a) contacting an olfactory receptor agonist with an olfactory receptor, (b) determining the

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PCT/US2017/054620 activity of the olfactory receptor, (c) contacting a test agent with the olfactory receptor, (d) determining the activity of the olfactory receptor, and (e) selecting the test agent as the composition when the activity of (d) is greater than or less than the activity of (b).

In certain embodiments, the olfactory receptor agonist is selected from the group consisting of trifemal, isovaleric acid, 3-methyl-2-hexanoic acid, alpha-ionone, hexyl acetate, amyl mercaptan, helional, para-anisaldehyde, 4-ethoxybenzaldehyde, menthol, methyl-eugenol, methyl-salicylate, phenylacetaldehyde, beta-ionone, amyl acetate, nonanethiol, acetophenone, coumarin, lilial, meta-anisaldehyde, 4-methyl-valeric acid, pentanol, allyl-phenylacetate, hexanoic acid, alpha-ionone, citral, isoamyl acetate, octanethiol, propiophenone, 7-methoxycoumarin and combinations thereof.

In certain non-limiting embodiments, the methods for identifying a compound that modulates the activity of an olfactory receptor described herein utilize cells expressing an olfactory receptor that is native to the cells. Examples of such cells expressing a native olfactory receptor include, for example but not limited to, human, dog and/or cat olfactory cells (e.g., olfactory receptor cells). In certain embodiments, the human, dog and/or cat olfactory cells expressing an olfactory receptor are isolated from a human, dog and/or cat and cultured in vitro. In certain embodiments, the olfactory receptor cells can be immortalized, for example, such that the cells isolated from a human, dog and/or cat can be propagated in culture.

In certain embodiments, the cell expresses a calcium-binding photoprotein, a cyclic nucleotide gated (CNG) channel, a cAMP response element (CRE)-containing luciferase reporter, a GloSensor luciferase, or a PKA-NanoBiT system. In certain embodiments, the calcium-binding photoprotein is selected from the group consisting of clytin, aequorin, obelin, any recombinant or isolated versions thereof, and any combinations thereof. In certain embodiments, an intracellular calcium level is monitored by luminescence detection or fluorescence detection. In certain embodiments, the fluorescence detection comprises a calcium sensitive fluorescent dye selected from the group consisting of Fura-2 AM, Fura-2 pentapotassium, Fura Red AM, Indo-1 AM, Indo-1 pentapotassium, Fluo-3, Fluo-4, Fluo-8, Calcium Green-1, Calcium 3, Calcium 4, Calcium 5, Rhod-2, derivatives thereof and combinations thereof.

In certain embodiments, the test agent has an EC50 value of no more than about 200 μΜ. In certain embodiments, the test agent has an Emax value of no less than about 2.0.

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The present disclosure also provides for methods for identifying compounds that enhance, increase, decrease and/or modulate the activity and/or expression of an olfactory receptor, wherein the assay is conducted using a cell-free assay, for example, wherein the olfactory receptor is bound to or otherwise attached to a substrate.

The present disclosure also provides for methods for identifying compounds that enhance, increase, decrease and/or modulate the activity and/or expression of an olfactory receptor, wherein the assay is conducted using an in silico model of the olfactory receptor, for example, wherein the olfactory receptor is modeled using a computer program and binding of the compound to the receptor is predicted through docking algorithms.

The presently disclosed subject matter further provides a method for making a palatable pet food product, wherein the raw materials used to generate the pet food product are screened to determine if they contain compounds that enhance, increase, decrease and/or modulate the activity and/or expression of an olfactory receptor, in certain embodiments, the raw material is a novel protein source. In certain embodiments the raw material is a protein source that is not commonly consumed in the human food chain. In certain embodiments, a raw pet food product that comprises a compound that increases the activity and/or expression of an olfactory receptor (for example, as compared to an olfactory receptor not contacted with the raw material) is not selected for use in generating a finished pet food product. In certain embodiments, a raw pet food product that comprises a compound that increases the activity and/or expression of an olfactory receptor (for example, as compared to an olfactory receptor not contacted with the raw material) is selected for use in generating a finished pet food product. In other embodiments, a raw pet food material that does not increase the activity and/or expression of an olfactory receptor (or that reduces the activity of an olfactory receptor, for example, in the presence of an olfactory receptor agonist) is selected for generating a finished pet food product. In other embodiments, a raw pet food material that does not increase the activity and/or expression of an olfactory receptor (or that reduces the activity of an olfactory receptor, for example, in the presence of an olfactory receptor agonist) is not selected for generating a finished pet food product.

The presently disclosed subject matter further provides a method for making a palatable pet food product, wherein the finished pet food product is screened to determine if it contains compounds that enhance, increase, decrease and/or modulate the activity and/or expression of an olfactory receptor. In certain embodiments, the

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PCT/US2017/054620 compounds are formed during the manufacturing process. In one embodiment, a finished pet food product that comprises a compound that increases the activity and/or expression of an olfactory receptor (for example, as compared to an olfactory receptor not contacted with the finished pet food product) is supplemented with one or more compounds that decrease the activity and/or expression of an olfactory receptor (for example, an antagonist compound). In one embodiment, a finished pet food product that comprises a compound that decreases the activity and/or expression of an olfactory receptor (for example, as compared to an olfactory receptor not contacted with the finished pet food product, or as compared to an olfactory receptor contacted with an agonist) is supplemented with one or more compounds that increases the activity and/or expression of an olfactory receptor (for example, an agonist compound).

The presently disclosed subject matter further provides a method for making a palatable pet medicine product, wherein the finished pet medicine product is screened to determine if it contains compounds that enhance, increase, decrease and/or modulate the activity and/or expression of an olfactory receptor, in certain embodiments, the compounds are formed during the manufacturing process. In one embodiment, a finished pet medicine product that comprises a compound that increases the activity and/or expression of an olfactory receptor (for example, as compared to an olfactory receptor not contacted with the finished pet medicine product) is supplemented with one or more compounds that decrease the activity and/or expression of an olfactory receptor (for example, an antagonist compound). In one embodiment, a finished pet medicine product that comprises a compound that decreases the activity and/or expression of an olfactory receptor (for example, as compared to an olfactory receptor not contacted with the finished pet medicine product, or as compared to an olfactory receptor contacted with an agonist) is supplemented with one or more compounds that increases the activity and/or expression of an olfactory receptor (for example, an agonist compound).

The presently disclosed subject matter further provides flavor compositions that comprise a modulator of an olfactory receptor, e.g., an agonist and/or an antagonist and/or an allosteric modulator and/or an inverse agonist, identified according to the methods described herein.

In certain embodiments, said compounds can be used in methods for maintaining the health of an animal by imparting a repellant odor and/or decreasing the palatability of an object or surface. In certain embodiments, the method comprises applying an odor deterrent product comprising a compound as described herein to the object or surface. In

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PCT/US2017/054620 certain embodiments, the object is harmful to the health of the animal or toxic to the animal.

The foregoing has outlined rather broadly the features and technical advantages of the present application in order that the detailed description that follows may be better understood. Additional features and advantages of the application will be described hereinafter which form the subject of the claims of the application. It should be appreciated by those skilled in the art that the conception and specific embodiment disclosed may be readily utilized as a basis for modifying or designing other structures for carrying out the same purposes of the present application. It should also be realized by those skilled in the art that such equivalent constructions do not depart from the spirit and scope of the application as set forth in the appended claims. The novel features which are believed to be characteristic of the application, both as to its organization and method of operation, together with further objects and advantages will be better understood from the following description.

BRIEF DESCRIPTION OF THE DRAWINGS

Figure 1 shows human, canine and feline olfactory receptor (OR) nucleotide sequences (SEQ ID NOs: 1-30) along with their corresponding amino acid sequences (SEQ ID NOs:31-60). The sequences include the human olfactory receptor HsORl 7.1.11 (hOR3Al), HsOR 1.4.8 (hOR6Pl), HsORl 1.3.14 (hOR51 El),

HsOR 11.3.40 (hOR51Ll), HsOR14.1.27 (hORl 1H6), HsORl 1.13.7 (hOR4D6),

HsOR 14,2.5 (hOR4E2), HsORl6.1.3 (hOR2Cl), HsORl 1.13.6 (hOR5Al), and HsORl 1.18.36 (hOR8B8); the canine olfactory receptor CafaOR9.2.9, CafaOR38.1.21, CafaOR21.2,15, CafaOR21.2.43, CafaOR 15.2.20, CafaORl8.3.11, CafaORl5.3.1, CafaOR6.3.1, CafaOR18.3.12, and CafaOR5.2.5; and the feline olfactory receptor El: 13347030-13347977, F1:65134904-65135858, D1:62955839-62956792,

D1:63312327-63313289, B3:72908295-72909287, D1:105486528-105487493,

B3:74116955-74117893, E3:40237904-40238842, DI :105462554-105463512, and DI :21266824-2 3 267768.

Figures 2A-2E. A) Alignment of canine, feline, and human olfactory receptor sequences as labeled (SEQ ID NOs:41, 51 and 31, respectively, in order of appearance). The active site, defined as those residues within 9 A (1 A - 10^_1(i m) of any heavy atom in the ligand, is highlighted by black boxes over the sequence alignment. Residues Nterminal to the seven-transmembrane domain are included for ease of identifying

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PCT/US2017/054620 residues by number within the protein sequence. Residues C-terminal to the seventransmembrane domain are not included in the alignments. B) Chemical structure of the ligand (Lilial) used in the modeling. C) A near view of the ligand bound to the canine receptor CafaOR9.2.9. The figure illustrates where the compound binds within the seven-helical transmembrane-domain (7TM) of the chosen receptor. D) A near view of the ligand bound to the receptor that illustrates residues defining the environment of the bound ligand. A smaller number of residues is chosen relative to those highlighted in A) for ease of viewing. E) An interaction map of the ligand bound the receptor that illustrates residues defining the environment of the bound ligand. Residues that can contact the ligand are shown as circles. Dark circles are those that interact primarily through van der Waals or hydrophobic contacts. Lighter circles are those that interact with ligand via other interaction types such as hydrogen bonds, ring stacking, salt bridges. When present, a halo around a circle indicates that there is significant loss of water-accessible surface area for that residue on ligand binding. When present, hydrogen bonds are indicated by dotted lines. Residues that can potentially make hydrogen bond with the ligand include Gin 103. Additional residues that can potentially make ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals interactions, or hydrophobic interactions with the ligand include Leu 104, Lys275, Arg87, Val81, Met84, Val279, Tyr262, Met209, Gly258, Vail 11, Tyr255, Thr282, Phel07 and Thr80.

Figures 3A-3E, A) Alignment of canine, feline, and human olfactory receptor sequences as labeled (SEQ ID NOs: 52, 32 and 42, respectively, in order of appearance). The active site, defined as those residues within 9 A (3 A — 10 ^liJ m) of any heavy atom in the ligand, is highlighted by black boxes over the sequence alignment. Residues Ntenninal to the seven-transmembrane domain are included for ease of identifying residues by number within the protein sequence. Residues C-terminal to the seventransmembrane domain are not included in the alignments. B) Chemical structure of the ligand (p-Anisaldehyde) used in the modeling. C) A near view of the ligand bound to the canine receptor CafaOR38.1.21. The figure illustrates where the compound binds within the seven-helical transmembrane-domain (7TM) of the chosen receptor. D) A near view of the ligand bound to the receptor that illustrates residues defining the environment of the bound ligand. A smaller number of residues is chosen relative to those highlighted in A) for ease of viewing. E) An interaction map of the ligand bound the receptor that illustrates residues defining the environment of the bound ligand. Residues that can

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PCT/US2017/054620 contact the ligand are shown as circles. Dark circles are those that interact primarily through van der Waals or hydrophobic contacts. Lighter circles are those that interact with ligand via other interaction types such as hydrogen bonds, ring stacking, salt bridges. When present, a halo around a circle indicates that there is significant loss of water-accessible surface area for that residue on ligand binding. When present, hydrogen bonds are indicated by dotted lines. Residues that can potentially make hydrogen bond with the ligand include Lys273. Additional residues that can potentially make ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals, or hydrophobic interactions with the ligand include Thr78, Leu82, Tyr260, Thr256, Tyi'253 and Phel05.

Figures 4A-4E. A) Alignment of canine, feline, and human olfactory receptor sequences as labeled (SEQ ID NOs: 43, 53 and 33, respectively, in order of appearance). The active site, defined as those residues within 9 A (1 A = 10 ¹⁰ m) of any heavy atom in the ligand, is highlighted by black boxes over the sequence alignment. Residues Nterminal to the seven-transmembrane domain are included for ease of identifying residues by number within the protein sequence. Residues C-terminal to the seventransmembrane domain are not included in the alignments. B) Chemical structure of the ligand ((+) -menthol) used in the modeling. C) A near view of the ligand bound to the canine receptor CafaOR21.2.15. The figure illustrates where the compound binds within the seven-helical transmembrane-domain (7TM) of the chosen receptor. D) A near view of the ligand bound to the receptor that illustrates residues defining the environment of the bound ligand. A smaller number of residues is chosen relative to those highlighted in A) for ease of viewing, E) An interaction map of the ligand bound the receptor that illustrates residues defining the environment of the bound ligand. Residues that can contact the ligand are shown as circles. Dark circles are those that interact primarily through van der Waals or hydrophobic contacts. Lighter circles are those that interact with ligand via other interaction types such as hydrogen bonds, ring stacking, salt bridges. When present, a halo around a circle indicates that there is significant loss of water-accessible surface area for that residue on ligand binding. When present, hydrogen bonds are indicated by dotted lines. Residues that can potentially make ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals, or hydrophobic interactions with the ligand include Met83, Hisl07, Ilel 06, Leul82, Asnl97, Gly201, Val204, Ser260, Phe256 and Leu273. Additional residues that can

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PCT/US2017/054620 potentially make van der Waals or hydrophobic interaction with the ligand include Met 103.

Figures 5A-5E, A) Alignment of canine, feline, and human olfactory receptor sequences as labeled (SEQ ID NOs:34, 44 and 54, respectively, in order of appearance). The active site, defined as those residues within 9 A (1 A = 10¹¹¹ m) of any heavy atom in the ligand, is highlighted by black boxes over the sequence alignment. Residues Nterminal to the seven-transmembrane domain are included for ease of identifying residues by number within the protein sequence. Residues C-terminal to the seventransmembrane domain are not included in the alignments. B) Chemical structure of the ligand (Androstadienone) used in the modeling. C) A near view of the ligand bound to the canine receptor CafaOR21.2.43. The figure illustrates where the compound binds within the seven-helical transmembrane-domain (7TM) of the chosen receptor. D) A near view of the ligand bound to the receptor that illustrates residues defining the environment of the bound ligand. A smaller number of residues is chosen relative to those highlighted in A) for ease of viewing. E) An interaction map of the ligand bound the receptor that illustrates residues defining the environment of the bound ligand. Residues that can contact the ligand are shown as circles. Dark circles are those that interact primarily through van der Waals or hydrophobic contacts. Lighter circles are those that interact with ligand via other interaction types such as hydrogen bonds, ring stacking, salt bridges. When present, a halo around a circle indicates that there is significant loss of water-accessible surface area for that residue on ligand binding. When present, hydrogen bonds are indicated by dotted lines. Residues that can potentially make ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals, or hydrophobic interactions with the ligand include Met80, Met88, Leul08, Hell 1, Hisl 12, Thrll5, Val209, Val210, Thr213, Leu214, Val262, lle263, Ser266, Ile281, Ala284, and Leu288. Additional residues that can potentially make van der Waals or hydrophobic interaction with the ligand include Asp285.

Figures 6A-6E. A) Alignment of canine, feline, and human olfactory receptor sequences as labeled (SEQ ID NOs;35, 45 and 55, respectively, in order of appearance). The active site, defined as those residues within 9 A (1 A = 10”^!° m) of any heavy atom in the ligand, is highlighted by black boxes over the sequence alignment. Residues Nterminal to the seven-transmembrane domain are included for ease of identifying residues by number within the protein sequence. Residues C-terminal to the seventransmembrane domain are not included in the alignments. B) Chemical structure of the

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PCT/US2017/054620 ligand (isobutene acid) used in the modeling. C) A near view of the ligand bound to the feline receptor catGrS (B3:72908295-72909287). The figure illustrates where the compound binds within the seven-helical transmembrane-domain (7TM) of the chosen receptor. D) A near view of the ligand bound the receptor that illustrates residues defining the environment of the bound ligand. A smaller number of residues is chosen relative to those highlighted in A) for ease of viewing. E) An interaction map of the ligand bound to the receptor that illustrates residues defining the environment of the bound ligand. Residues that can contact the ligand are shown as circles. Dark circles are those that interact primarily through van der Waals or hydrophobic contacts. Lighter circles are those that interact with ligand via other interaction types such as hydrogen bonds, ring stacking, salt bridges. When present, a halo around a circle indicates that there is significant loss of water-accessible surface area for that residue on ligand binding. When present, hydrogen bonds are indicated by dotted lines. Residues that can potentially make hydrogen bond with the ligand include Tyr277. Additional residues that can potentially make ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals, or hydrophobic interactions with the ligand include Phel 19, Prol77, Leul80, Ilel81, Prol99, Cys217, and Phe220. Additional residues that can potentially make van der Waals or hydrophobic interaction with the ligand include Tyr277 and Lys290.

Figures 7A-7E. A) Alignment of canine, feline, and human olfactory receptor sequences as labeled (SEQ ID NOs:36, 56 and 46, respectively, in order of appearance). The active site, defined as those residues within 9 A (1 A = 10^-i° m) of any heavy atom in the ligand, is highlighted by black boxes over the sequence alignment. Residues Ntenninal to the seven-transmembrane domain are included for ease of identifying residues by number within the protein sequence. Residues C-terminal to the seventransmembrane domain are not included in the alignments. B) Chemical structure of the ligand (β-ionone) used in the modeling. C) A near view of the ligand bound to the feline receptor catGr6 (DI :105486528-105487493). The figure illustrates where the compound binds within the seven-helical transmembrane-domain (7TM) of the chosen receptor, D) A near view of the ligand bound to the receptor that illustrates residues defining the environment of the bound ligand. A smaller number of residues is chosen relative to those highlighted in A) for ease of viewing. E) An interaction map of the ligand bound the receptor that illustrates residues defining the environment of the bound ligand.

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Residues that can contact the ligand are shown as circles. Dark circles are those that interact primarily through van der Waals or hydrophobic contacts. Lighter circles are those that interact with ligand via other interaction types such as hydrogen bonds, ring stacking, salt bridges. When present, a halo around a circle indicates that there is significant loss of water-accessible surface area for that residue on ligand binding. When present, hydrogen bonds are indicated by dotted lines. Residues that can potentially make hydrogen bond with the ligand include Tyr265. Additional residues that can potentially make ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals, or hydrophobic interactions with the ligand include Phe88, Phel 11, Metl 70, Met206, Cys261, Ile264, Ser279, lle280, and Thr283. Additional residues that can potentially make van der Waals or hydrophobic interaction with the ligand include Hisl 12, Asn209 and Tyr265.

Figures 8A-8E. A) Alignment of canine, feline, and human olfactory receptor sequences as labeled (SEQ ID NOs:47, 37 and 57, respectively, in order of appearance). The active site, defined as those residues within 9 A (1 Ά = 10“¹⁰ m) of any heavy atom in the ligand, is highlighted by black boxes over the sequence alignment. Residues Nterminal to the seven-transmembrane domain are included for ease of identifying residues by number within the protein sequence. Residues C-terminal to the seventransmembrane domain are not included in the alignments. B) Chemical structure of the ligand (Amyl acetate) used in the modeling, C) A near view of the ligand bound to the feline receptor catG7 (B3:74116955-74117893). The figure illustrates where the compound binds within the seven-helical transmembrane-domain (7TM) of the chosen receptor. D) A near view of the ligand bound to the receptor that illustrates residues defining the environment of the bound ligand. A smaller number of residues is chosen relative to those highlighted in A) for ease of viewing. E) An interaction map of the ligand bound the receptor that illustrates residues defining the environment of the bound ligand. Residues that can contact the ligand are shown as circles. Dark circles are those that interact primarily through van der Waals or hydrophobic contacts. Lighter circles are those that interact with ligand via other interaction types such as hydrogen bonds, ring stacking, salt bridges. When present, a halo around a circle indicates that there is significant loss of water-accessible surface area for that residue on ligand binding. When present, hydrogen bonds are indicated by dotted lines. Residues that can potentially make hydrogen bond with the ligand include Met81, Tyr258, and Gin 100. Additional residues that can potentially make ring stacking, salt bridges, hydrogen bonding, pi

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PCT/US2017/054620 interactions, charged interactions, van der Waals, or hydrophobic interactions with the ligand Thr77, Lys269, Leul04, Thr276, Val277, His73, Val273 and Val78.

Figures 9A-9E. A) Alignment of canine, feline, and human olfactory receptor sequences as labeled (SEQ ID NOs:38, 58 and 48, respectively, in order of appearance). The active site, defined as those residues within 9 A (1 A - KT¹⁰ m) of any heavy atom in the ligand, is highlighted by black boxes over the sequence alignment. Residues Nterminal to the seven-transmembrane domain are included for ease of identifying residues by number within the protein sequence. Residues C-terminal to the seventransmembrane domain are not included in the alignments. B) Chemical structure of the ligand (1-nonanethiol) used in the modeling. C) A near view of the ligand bound to the feline receptor catG8 (E3:40237904-40238842). The figure illustrates where the compound binds within the seven-helical transmembrane-domain (7TM) of the chosen receptor. D) A near view of the ligand bound to the receptor that illustrates residues defining the environment of the bound ligand. A smaller number of residues is chosen relative to those highlighted in A) for ease of viewing. E) An interaction map of the ligand bound the receptor that illustrates residues defining the environment of the bound ligand. Residues that can contact the ligand are shown as circles. Dark circles are those that interact primarily through van der Waals or hydrophobic contacts. Lighter circles are those that interact with ligand via other interaction types such as hydrogen bonds, ring stacking, salt bridges. When present, a halo around a circle indicates that there is significant loss of water-accessible surface area for that residue on ligand binding. When present, hydrogen bonds are indicated by dotted lines. Residues that can potentially make ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions with the ligand include Leu 101, Phel04, Leul05, Glyl08, Glu 180, Val202, Phe206, Tyr259, and Lys272. Additional residues that can potentially make van der Waals or hydrophobic interaction with the ligand include Met81.

Figures 10A-10E. A) Alignment of canine, feline, and human olfactory receptor sequences as labeled (SEQ ID NOs:49, 59 and 39, respectively, in order of appearance). The active site, defined as those residues within 9 A (1 A = 10 ^!(J m) of any heavy atom in the ligand, is highlighted by black boxes over the sequence alignment. Residues Nterminal to the seven-transmembrane domain are included for ease of identifying residues by number within the protein sequence. Residues C-terminal to the seventransmembrane domain are not included in the alignments. B) Chemical structure of the ligand (β-ionone) used in the modeling. C) A near view of the ligand bound to the feline

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PCT/US2017/054620 receptor catG9 (01:105462554-105463512). The figure illustrates where the compound binds within the seven-helical transmembrane-domain (7TM) of the chosen receptor. D) A near view of the ligand bound to the receptor that illustrates residues defining the environment of the bound ligand. A smaller number of residues is chosen relative to those highlighted in A) for ease of viewing. E) An interaction map of the ligand bound the receptor that illustrates residues defining the environment of the bound ligand. Residues that can contact the ligand are shown as circles. Dark circles are those that interact primarily through van der Waals or hydrophobic contacts. Lighter circles are those that interact with ligand via other interaction types such as hydrogen bonds, ring stacking, salt bridges. When present, a halo around a circle indicates that there is significant loss of water-accessible surface area for that residue on ligand binding. When present, hydrogen bonds are indicated by dotted lines. Residues that can potentially make hydrogen bond with the ligand include Lys278. Additional residues that can potentially make ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions with the ligand include Phel 10, Vail 11, Glyl 14, Val2O8,13e212, Phe258, A3a261, Leu262, Tyr265, Val282, and Ser285. Additional residues that can potentially make van der Waals or hydrophobic interaction with the ligand include Tyr79 and Lys278.

Figures 11 A-l IE. A) Alignment of canine, murine, feline, and human olfactory receptor sequences as labeled (SEQ ID NOs:60, 3,809, 50 and 40, respectively, in order of appearance). The active site, defined as those residues within 9 A (1 A = 10 ^,θ m ) of any heavy atom in the ligand, is highlighted by black boxes over the sequence alignment. Residues N-terminal to the seven-transmembrane domain are included for ease of identifying residues by number within the protein sequence, Residues C-terminal to the seven-transmembrane domain are not included in the alignments. B) Chemical structure of the ligand (Coumarin) used in the modeling. C) A near view of the ligand bound to the canine receptor CafaOR5.2.5. The figure illustrates where the compound binds within the seven-helical transmembrane-domain (7TM) of the chosen receptor. D) A near view of the ligand bound to the receptor that illustrates residues defining the environment of the bound ligand. A smaller number of residues is chosen relative to those highlighted in A) for ease of viewing. E) An interaction map of the ligand bound the receptor that illustrates residues defining the environment of the bound ligand. Residues that can contact the ligand are shown as circles. Dark circles are those that interact primarily through van der Waals or hydrophobic contacts. Lighter circles are those that interact

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PCT/US2017/054620 with ligand via other interaction types such as hydrogen bonds, ring stacking, salt bridges. When present, a halo around a circle indicates that there is significant loss of water-accessible surface area for that residue on ligand binding. When present, hydrogen bonds are indicated by dotted lines. Residues that can potentially make ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions with the ligand include Tyr77, Phel08, Vail 12, Seri 16, Val206, Asp210, Phe256, and Thr283. Additional residues that can potentially make van der Waals or hydrophobic interaction with the ligand include Tyr263.

Figure 12 shows native olfactory receptor signaling pathway and possible functional assays.

Figure 13 shows a phylogenetic tree for multi-species (human/canine/feline) covering the olfactory genetic space. The phylogenetic tree shows all olfactory receptors and highlighted the 30 selected olfactory receptors (10 human receptors, 10 canine receptors, 10 feline receptors).

Figure 14 shows the summarized results of phase 2 testing of OR] to OR_5 in Example 4.

Figure 15 shows the summarized results of phase 2 testing of OR6 to OR_10 in Example 4.

Figure 16 shows the summarized results of phase 3 testing of dog ORs in Example 4.

Figure 17 shows the summarized results of phase 3 testing of cat ORs in Example

4.

Figure 18 shows the results of the CRE-NanoLuc luciferase assay using OR1 (OR3A1).

Figure 19 shows the results of the chAMPion assay using OR_1 (OR3A1).

Figure 20 shows the results of the CRE-NanoLuc luciferase assay using OR_2 (OR6P1).

Figure 21 shows the results of the chAMPion assay using OR_2 (OR6P1).

Figure 22 shows the results of the CRE-NanoLuc luciferase assay using OR 3 (OR51E1).

Figure 23 shows the results of the chAMPion assay using OR . 3 (OR51E1).

Figure 24 shows the results of the CRE-NanoLuc luciferase assay using OR 4 (OR51L1).

Figure 25 shows the results of the chAMPion assay using OR4 (OR51 LI).

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Figure 26 shows the results of the CRE-NanoLuc luciferase assay using OR_5 (OR11H6).

Figure 27 shows the results of the chAMPion assay using OR_5 (OR11H6).

Figure 28 shows the results of the CRE-NanoLuc luciferase assay using OR 6 (OR4D6).

Figure 29 shows the results of the chAMPion assay using OR 6 (OR4D6).

Figure 30 shows the results of the CRE-NanoLuc luciferase assay using OR 7 (OR4E2).

Figure 31 shows the results of the chAMPion assay using OR 7 (OR4E2).

Figure 32 shows the results of the CRE-NanoLuc luciferase assay using OR_8 (OR2C1).

Figure 33 shows the results of the chAMPion assay using OR8 (OR2C1).

Figure 34 shows the results of the CRE-NanoLuc luciferase assay using OR 9 (OR5A1).

Figure 35 shows the results of the chAMPion assay using OR_9 (OR5A1).

Figure 36 shows the results of the CRE-NanoLuc luciferase assay using OR10 (OR8B8).

Figure 37 shows the results of the chAMPion assay using OR 10 (OR8B8).

Figures 38A-38B show the dose-response curves of the positive ligands for OR 2 (OR6P1). A) The dose-response curves of para-anisaldehyde using mock, feline and canine receptors. B) The dose-response curves of 4-ethoxybenzaldehyde using mock, feline and canine receptors.

Figures 39A-39D show the dose-response curves of the positive ligands for OR 3 (ORS 1 El). A) The dose-response curves of isovaleric acid using mock, feline and canine receptors. B) The dose-response curves of 4-methyl-valeric acid using mock, feline and canine receptors. C) The dose-response curves of hexanoic acid using mock, feline and canine receptors. D) The dose-response curves of 3-methyl-2-hexanoic acid using mock, feline and canine receptors.

Figures 40A-40B show the dose-response curves of the positive ligands for OR_4 (OR51L1). A) The dose-response curves of hexanoic acid using mock, feline and canine receptors. B) The dose-response curves of allyl-phenylacetate using mock, feline and canine receptors.

Figures 41A-41B show the dose-response curves of the positive ligands for OR8 (OR2C1). A) The dose-response curves of nonanethiol using mock, feline and canine

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PCT/US2017/054620 receptors and using the CRE-NanoLuc luciferase assay. B) The dose-response curves of nonanethiol using mock, feline and canine receptors and using the CNG assay.

Figures 42A-42H show the dose-response curves of the positive ligands for OR 9 (OR5A1). A) The dose-response curves of isovaleric acid using mock, feline and canine receptors and using the CRE-NanoLuc luciferase assay. B) The dose-response curves of citral using mock, feline and canine receptors and using the CRE-NanoLuc luciferase assay. C) The dose-response curves of amyl acetate using mock, feline and canine receptors and using the CRE-NanoLuc luciferase assay. D) The dose-response curves of beta-ionone using mock, feline and canine receptors and using the CRE-NanoLuc luciferase assay. E) The dose-response curves of isovaleric acid using mock, feline and canine receptors and using the CNG assay. F) The dose-response curves of citral using mock, feline and canine receptors and using the CNG assay. G) The dose-response curves of amyl acetate using mock, feline and canine receptors and using the CNG assay. H) The dose-response curves of beta-ionone using mock, feline and canine receptors and using the CNG assay. Human OR5A1 is only responsive in CRE-Nanoluc assay, which responds only to β-ionone. Dog OR5A1 has slightly different response profile in both assays: in CRE-NanoLuc assay the receptor responds to all four compounds with similar EC50 and Emax; in CNG assay the receptor responds to all four compounds, but the response to β-ionone has the lowest EC50 and the highest Emax. Cat OR5A1 has different response profile in both assays: in CRE-NanoLuc assay the receptor responds to all four compounds with similar EC50 and Emax; in CNG assay the receptor has strong response only to β-ionone, but has weaker responses for isovaleric acid and amyl acetate, and no response to citral. The difference in response profiles in both assays might be due to different assay protocols and longer incubation times in the CRE-NanoLuc assay.

Figures 43A-43C show the dose-response curves of the positive ligands for OR10 (OR8B8). A) The dose-response curves of acetophenone using mock, feline and canine receptors. B) The dose-response curves of propriophenone using mock, feline and canine receptors. C) The dose-response curves of coumarin using mock, feline and canine receptors.

DETAILED DESCRIPTION

The presently disclosed subject matter relates to methods for screening and identifying compounds that modulate the activity and/or expression of olfactory receptors. The presently disclosed subject matter further relates to making fragrant,

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PCT/US2017/054620 palatable, nutritionally-complete pet food products, medicines, as well as nonnutritionally-complete pet food products (e.g., snack, care and treats), wherein the raw materials of the pet food and/or finalized pet food product or medicine is screened to determine if it contains compounds that modulate the olfactory receptors. Furthermore, such screening methods can be used to select raw materials and/or finalized pet food products that do not comprise repellant compounds. Compounds identified through said methods can be used to modify the fragrance and/or palatability of pet food products and medicines by increasing or decreasing an attractive or repellant odor. Said compounds can also be used to increase a repellant odor of an object, and thereby reduce contact, palatability and ingestion by a cat or a dog.

1. Definitions

The terms used in this specification generally have their ordinary meanings in the art, within the context of this invention and in the specific context where each term is used. Certain terms are discussed below, or elsewhere in the specification, to provide additional guidance to the practitioner in describing the methods and compositions of the invention and how to make and use them.

As used herein, the use of the word “a” or ari when used in conjunction with the term “comprising” in the claims and/or the specification may mean “one,” but it is also consistent with the meaning of “one or more,” “at least one,” and “one or more than one.” Still further, the terms “having,” “including,” “containing” and “comprising” are interchangeable and one of skill in the art is cognizant that these terms are open ended terms.

The term “about” or “approximately” means within an acceptable error range for the particular value as determined by one of ordinary skill in the art, which will depend in part on how the value is measured or determined, i.e., the limitations of the measurement system. For example, “about” can mean within 3 or more than 3 standard deviations, per the practice in the art. Alternatively, “about” can mean a range of up to 20%, preferably up to 10%, more preferably up to 5%, and more preferably still up to 3 % of a given value. Alternatively, particularly with respect to biological systems or processes, the term can mean within an order of magnitude, preferably within 5-fold, and more preferably within 2-fold, of a value.

As used interchangeably herein, “odor”, “smell” and “aroma” refer to a sensation caused by activation of receptor cells in a subject’s olfactory system. In certain embodiments, odor can be characterized by a set of psychophysical descriptors, such as,

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PCT/US2017/054620 for example, one or more of a fruity, floral, honey, fatty, minty and metallic smell. See, e.g., Dravnieks, Atlas of Odor Character Profiles, American Society for Testing and Materials, 1985; Castro et ah, PLOS ONE, 0073289, 2014, the contents of which are incorporated herein by reference. In certain embodiments, an olfactory sense is elicited in a subject by an “odorant.” in certain embodiments, combination of different odorants can be perceived as a new odor object. In certain embodiments, an odorant can be a synthetic odorant. In certain embodiments, the odorant is obtained or prepared from a natural source.

As used herein, “olfactory profile” refers to a combination of odor senses, each of which can be characterized by a set of psychophysical descriptors, such as, for example, one or more of a fruity, floral, honey, fatty, minty and metallic smell. In certain embodiments, a combination of different odorants can be perceived as a new odor sensory experience, in certain embodiments, an olfactory profile is produced by one or more odorant that is present in a composition at the same or different concentrations. In certain embodiments, an olfactory profile refers to the intensity of an odor or combination of odors, for example, a fruity, floral, honey, fatty, minty and metallic smell, as detected by a subject or any assay known in the art. In certain embodiments, modifying, changing or varying the combination of odorants in an olfactory profile can change the sensory experience of a subject.

As used herein, “flavor” refers to one or more sensory stimuli, such as, for example, one or more of taste (gustatory), smell (olfactory), touch (tactile) and temperature (thermal) stimuli. In certain non-limiting embodiments, the sensory experience of a subject exposed to a flavor can be classified as a characteristic experience for the particular flavor. For example, a flavor can be identified by the subject as being, but not limited to, a floral, citrus, berry, nutty, caramel, chocolate, peppery, smoky, cheesy, meaty, etc., flavor. As used herein, a flavor composition can be selected from a liquid, solution, dry powder, spray, paste, suspension and any combination thereof. The flavor can be a natural composition, an artificial composition, a nature identical, or any combination thereof.

As used herein, “flavor profile” refers to a combination of sensory stimuli, for example, tastes, olfactory, tactile and/or thermal stimuli. In certain embodiments, the flavor profile comprises one or more flavors which contribute to the sensory experience of a subject. In certain embodiments, modifying, changing or varying the combination of stimuli in a flavor profile can change the sensory experience of a subject.

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As used herein admixing,” for example, “admixing the flavor composition or combinations thereof of the present application with a food product,” refers to the process where the flavor composition, or individual components of the flavor composition, is mixed with or added to the completed product or mixed with some or all of the components of the product during product formation or some combination of these steps. When used in the context of admixing, the term “product” refers to the product or any of its components. This admixing step can include a process selected iforn the step of adding the flavor composition to the product, spraying the flavor composition on the product, coating the flavor composition on the product, suspending the product in the flavor composition, painting the flavor composition on the product, pasting the flavor composition on the product, encapsulating the product with the flavor composition, mixing the flavor composition with the product and any combination thereof. The flavor composition can be a solution, liquid, dry powder, spray, paste, suspension and any combination thereof.

As used herein, “palatability” can refer to the overall willingness of a human or non-human animal, for example, a companion animal, to eat a certain food product. Increasing the “palatability” of a food product can lead to an increase in the enjoyment and acceptance of the food by the human or non-human animal to ensure the human or non-human animal eats a “healthy amount” of the food. Decreasing the “palatability” of a food product can lead to a decrease in the enjoyment and acceptance of the food by the human or non-human animal. The term “healthy amount” of a food as used herein refers to an amount that enables the human or non-huinan animal to maintain or achieve an intake contributing to its overall general health in terms of micronutrients, macronutrients and calories, for example, such as set out in the “Mars Petcare Essential Nutrient Standards.” In certain embodiments, “palatability” can mean a relative preference of a human or non-human animal for one food product over another. For example, when a human or non-human animal shows a preference for one of two or more food products, the preferred food product is more “palatable,” and has “enhanced palatability.” In certain embodiments, the relative palatability of one food product compared to one or more other food products can be determined, for example, in sideby-side, lfee-choice comparisons, e.g., by relative consumption of the food products, or other appropriate measures of preference indicative of palatability. Palatability can be determined by a standard testing protocol in which the animal has equal access to both food products such as a test called “two-bowl test” or “versus test.” Such preference can

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PCT/US2017/054620 arise from any of the animal's senses, but can be related to, inter alia, taste, aftertaste, smell, mouth feel and/or texture.

The term “pet food” or “pet food product” or “final pet food product” means a product or composition that is intended for consumption by a companion animal, such as cats, dogs, guinea pigs, rabbits, birds and horses. For example, but not by way of limitation, the companion animal can be a “domestic” dog, e.g., Canis lupus familiaris. in certain embodiments, the companion animal can be a “domestic” cat such as Felis domesticus. A “pet food” or “pet food product” includes any food, feed, snack, food supplement, liquid, beverage, treat, toy (chewable and/or consumable toys), meal substitute or meal replacement.

The term “human food” or “human food product” or “final human food product” means a product or composition that is intended for consumption by a human. A “human food” or “human food product” includes any food, feed, snack, food supplement, liquid, beverage, treat, meal substitute or meal replacement.

In certain embodiments, a “food product” includes human and/or pet food products.

As used herein “nutritionally-compiete” refers to pet food product that contains all known required nutrients for the intended recipient of the pet food product, in appropriate amounts and proportions based, for example, on recommendations of recognized or competent authorities in the field of companion animal nutrition. Such foods are therefore capable of serving as a sole source of dietary intake to maintain life, without the addition of supplemental nutritional sources.

The term “raw material” means a plant and/or animal material before being processed or manufactured into a final pet food product. In certain embodiments, a “raw material” is not significantly processed in order to separate it into individual elements prior to analysis (e.g., by extraction, purification, fractionation and/or concentration). A “raw material” includes a protein source for a pet food product. In certain embodiments, the raw material is a novel protein source that does not compete with the human food sources {i.e., a protein source that is not commonly eaten by humans). In certain embodiments, the raw material is a by-product of the human food chain. In certain nonlimiting embodiments, the “raw material” is processed, for example, in order to separate it into individual elements prior to analysis (e.g., by extraction, purification, fractionation and/or concentration), prior to being analyzed according to the methods described herein.

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As used herein “flavor composition” refers to at least one compound or biologically acceptable salt thereof that modulates, including enhancing, multiplying, potentiating, decreasing, suppressing, or inducing, the tastes, smells, flavors and/or textures of a natural or synthetic tastant, flavoring agent, taste profile, flavor profile and/or texture profile in an animal or a human. In certain embodiments, the flavor composition comprises a combination of compounds or biologically acceptable salts thereof. In certain embodiments, the flavor composition includes one or more excipients.

As used herein, “odor deterrent,” “odor deterrent product,” or “odor deterrent composition” refers to a product or composition containing at least one compound or biologically acceptable salt thereof that provides a repellant odor to an object. In certain embodiments, the odor deterrent discourages an animal from contacting, approaching, chewing, licking, or consuming an object, for example, a food or liquid product. In certain embodiments, the object is, for example but not limited to, clothing, shoes, carpet, furniture, household items, pesticides, herbicides, or poisonous compounds. In certain embodiments, the object is another animal or the animal itself. In other embodiment, the object is toxic to the animal, or would be detrimental to the animal’s health upon contact or ingestion.

As used herein, the terms “modulates” or “modifies” refers to an increase or decrease in the amount, quality or effect of a particular activity of a receptor and/or an increase or decrease in the expression, activity or function of a receptor. “Modulators,” as used herein, refer to any inhibitory or activating compounds identified using in silico, in vitro and/or in vivo assays for, e.g., agonists, antagonists, allosteric modulators and their homologs, including fragments, variants and mimetics.

“Inhibitors” or “antagonists,” as used herein, refer to modulating compounds that reduce, decrease, block, prevent, delay activation, inactivate, desensitize or down regulate the biological activity and/or expression of a receptor or pathway of interest.

The term “antagonist” includes full, partial, and neutral antagonists as well as inverse agonists.

“Inducers,” “activators” or “agonists,” as used herein, refer to modulating compounds that increase, induce, stimulate, open, activate, facilitate, enhance activation, sensitize or upregulate a receptor or pathway of interest. The term “agonist” includes full and partial agonists.

“Allosteric modulators” as used herein, refer to “positive allosteric modulators” and “negative allosteric modulators,” “Positive allosteric modulators” refer to

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PCT/US2017/054620 modulating compounds that increase, induce, stimulate, open, activate, facilitate, enhance activation, sensitize or up regulate a receptor or pathway of interest caused by the binding of a different compound to the receptor. “Negative allosteric modulators” refer to modulating compounds that reduce, decrease, block, prevent, delay activation, inactivate, desensitize or down regulate the biological activity and/or expression of a receptor or pathway of interest caused by the binding of a different compound to the receptor.

As used herein, the terms “vector” and “expression vector” refer to DNA molecules that are either linear or circular, into which another DNA sequence fragment of appropriate size can be integrated. Such DNA fragment(s) can include additional segments that provide for transcription of a gene encoded by the DNA sequence fragment. The additional segments can include and are not limited to: promoters, transcription terminators, enhancers, internal ribosome entry sites, untranslated regions, polyadenylation signals, selectable markers, origins of replication and such like. Expression vectors are often derived from plasmids, cosmids, viral vectors and yeast artificial chromosomes. Vectors are often recombinant molecules containing DNA sequences from several sources.

The term “operably linked,” when applied to DNA sequences, for example in an expression vector, indicates that the sequences are arranged so that they function cooperatively in order to achieve their intended purposes, i.e., a promoter sequence allows for initiation of transcription that proceeds through a linked coding sequence as far as the termination signal.

The term “nucleic acid molecule” and “nucleotide sequence,” as used herein, refers to a single or double stranded covalently-linked sequence of nucleotides in which the 3' and 5' ends on each nucleotide are joined by phosphodiester bonds. The nucleic acid molecule can include deoxyribonucleotide bases or ribonucleotide bases, and can be manufactured synthetically in vitro or isolated from natural sources.

The terms “polypeptide,” “peptide,” “amino acid sequence” and “protein,” used interchangeably herein, refer to a molecule formed from the linking of at least two amino acids. The link between one amino acid residue and the next is an amide bond and is sometimes referred to as a peptide bond. A polypeptide can be obtained by a suitable method known in the art, including isolation from natural sources, expression in a recombinant expression system, chemical synthesis or enzymatic synthesis. The terms can apply to amino acid polymers in which one or more amino acid residue is an

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PCT/US2017/054620 artificial chemical mimetic of a corresponding naturally occurring amino acid, as well as to naturally occurring amino acid polymers and non-naturally occurring amino acid polymers.

The term “amino acid,” as used herein, refers to naturally occurring and synthetic amino acids, as well as amino acid analogs and amino acid mimetics that function in a manner similar to the naturally occurring amino acids. Naturally occurring amino acids are those encoded by the genetic code, as well as those amino acids that are later modified, e.g., hydroxyproline, gamma-carboxyglutamate and O-phosphoserine. Amino acid analogs and derivatives can refer to compounds that have the same basic chemical structure as a naturally occurring amino acid, i.e., a carbon that is bound to a hydrogen, a carboxyl group, an amino group and an R group, e.g., homoserine, norleucine, methionine sulfoxide and methionine methyl sulfonium. Such analogs can have modified R groups (e.g., norleucine) or modified peptide backbones, but retain the same basic chemical structure as a naturally occurring amino acid. Amino acid mimetics means chemical compounds that have a structure that is different from the general chemical structure of an amino acid, but that function in a manner similar to a naturally occurring amino acid.

The terms “isolated” or “purified”, used interchangeably herein, refers to a nucleic acid, a polypeptide, or other biological moiety that is removed from components with which it is naturally associated. The term “isolated” can refer to a polypeptide that is separate and discrete from the whole organism with which the molecule is found in nature or is present in the substantial absence of other biological macromolecules of the same type. The term “isolated” with respect to a polynucleotide can refer to a nucleic acid molecule devoid, in whole or part, of sequences normally associated with it in nature; or a sequence, as it exists in nature, but having heterologous sequences in association therewith; or a molecule disassociated from the chromosome.

As used herein, the term “recombinant” can be used to describe a nucleic acid molecule and refers to a polynucleotide of genomic, RNA, DNA, cDNA, viral, semisynthetic or synthetic origin which, by virtue of its origin or manipulation is not associated with all or a portion of the polynucleotide with which it is associated in nature.

The term “fusion,” as used herein, refers to joining of different peptide oi' protein segments by genetic or chemical methods wherein the joined ends of the peptide or

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PCT/US2017/054620 protein segments may be directly adjacent to each other or may be separated by linker or spacer moieties such as amino acid residues or other linking groups.

2. Olfactory Receptors

The presently disclosed subject matter provides olfactory receptors for use in the 5 disclosed methods. The olfactory receptors of the present disclosure can include mammalian olfactory receptors such as, but not limited to, human, canine and feline olfactory receptors.

In certain non-limiting embodiments, the olfactory receptor is a human olfactory receptor, for example, human olfactory receptor HsORl 7.1.11 (hOR3A1), HsOR 1.4.8 (hOR6P 1), HsORl 1.3.14 (hOR51E1), HsOR 11.3.40 (hOR51 LI), HsOR 14.1.27 (hORllH6), HsORl 1.13.7 (hOR4D6), HsOR14.2.5 (hOR4E2), HsOR16.1.3 (hOR2Cl), HsORll.13.6 (hOR5Al), HsORll.18.36 (hOR8B8), or combinations thereof.

In certain non-limiting embodiments, the olfactory receptor is a canine olfactory receptor, for example, canine olfactory receptor CafaOR9.2.9, CafaOR38.1.21,

CafaOR21.2.15, CafaOR21.2.43, CafaORl5.2.20, CafaOR18.3.11, CafaOR15.3.1, CafaOR6.3.1, CafaORl8.3.12, CafaOR5.2.5, or combinations thereof. In certain nonlimiting embodiments, the olfactory receptor is a canine olfactory receptor having a nucleotide sequence or an amino acid sequence set forth in SEQ ID NOs:61-2260.

In certain non-limiting embodiments, the olfactory receptor is a feline olfactory receptor, for example, feline olfactory receptor El :13347030-13347977, FI :6513490465135858, DI :62955839-62956792, 01:63312327-63313289, B3:72908295-72909287, DI :105486528-105487493, B3:74116955-74117893, E3:40237904-40238842, 01:105462554-105463512, D3:21266824-21267768, or combinations thereof. In certain non-limiting embodiments, the olfactory receptor is a feline olfactory receptor having a nucleotide sequence or an amino acid sequence set forth in SEQ ID NOs:2261 -3808.

The olfactory receptors tested in the working examples, along with their synonyms and group designations are listed in Table 1.

Table 1.

OR Orthologue Group	OR Orthologue Name	Human OR	Canine OR	Feline OR
OR_1	OR3A1	HsORl 7.3.11 (hOR3Al) (SEQ ID NOs: 1 and 31)	CafaOR9.2.9 (canine OR3A1) (SEQ ID NOs: 11 and 41)	El :13347030-13347977 (feline OR3A1) (SEQ ID NOs: 21 and 51)
OR_2	OR6P1	HsORl .4.8 (hOR6Pl)	CafaOR38.1.21 (canine OR6P3)	FI :65134904-65135858 (feline OR6P1)

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		(SEQ ID NOs: 2 and 32)	(SEQ ID NOs: 12 and 42)	(SEQ ID NOs: 22 and 52)
OR_3	OR51E1	HsORl 1.3.14 (hORSlEl) (SEQ ID NOs: 3 and 33)	CafaOR21.2.15 (canine OR51E1) (SEQ ID NOs: 13 and 43)	DI :62955839-62956792 (feline OR5IE1) (SEQ ID NOs: 23 and 53)
OR4	OR51L1	HsORl 1.3.40 (hOR51Ll) (SEQ ID NOs: 4 and 34)	CafaOR21.2.43 (canine OR51 LI) (SEQ ID NOs: 14 and 44)	01:63312327-63313289 (feline OR51 LI) (SEQ ID NOs: 24 and 54)
OR_5	OR11H6	HsOR14.1.27 (hORllH6) (SEQ ID NOs: 5 and 35)	CafaOR 3 5.2.20 (canine OR11H6) (SEQ ID NOs: 15 and 45)	B3:72908295-72909287 (feline OR11H6) (SEQ ID NOs: 25 and 55)
OR 6	OR4D6	HsORl 1.13.7 (hOR4D6) (SEQ ID NOs; 6 and 36)	CafaORl 8.3.11 (canine OR4D6) (SEQ ID NOs: 16 and 46)	01:105486528-105487493 (feline OR4D6) (SEQ ID NOs: 26 and 56)
OR_7	OR4E2	HsOR14.2.5 (hOR4E2) (SEQ ID NOs: 7 and 37)	CafaORl 5.3.1 (canine OR4E2) (SEQ ID NOs: 17 and 47)	B3:74116955-74117893 (feline OR4E2) (SEQ ID NOs: 27 and 57)
OR_8	OR2C1	HsORl 6.1.3 (hOR2Cl) (SEQ ID NOs: 8 and 38)	CafaOR6.3.1 (canine OR2C1) (SEQ ID NOs: 18 and 48)	£3:40237904-40238842 (feline OR2C1) (SEQ ID NOs: 28 and 58)
OR9	OR5A1	HsORl 1.13.6 (hOR5Al) (SEQ ID NOs: 9 and 39)	CafaORl 8.3.12 (canine OR5 A1) (SEQ ID NOs: 19 and 49)	Dl:105462554-105463512 (feline OR5A3) (SEQ ID NOs: 29 and 59)
OR 10	OR8B8	HsORl 1.18.36 (hOR8B8) (SEQ ID NOs: 10 and 40)	CafaOR5.2.5 (canine OR8B8) (SEQ ID NOs: 20 and 50)	DI :21266824-21267768 (feline OR8B8) (SEQ ID NOs: 30 and 60)

In certain embodiments, an olfactory receptor for use in the presently disclosed methods encompasses a canine olfactory receptor comprising a nucleotide sequence set forth in SEQ ID NO: 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20 , an amino acid sequence set forth in SEQ ID NO:41, 42, 43, 44, 45, 46, 47, 48, 49, or 50, and/or a nucleotide sequence or an amino acid sequence set forth in SEQ ID NOs:61-2260, including fragments thereof (e.g., functional fragments thereof) and variants thereof.

In certain embodiments, an olfactory receptor for use in the presently disclosed methods encompasses a feline olfactory receptor comprising a nucleotide sequence set forth in SEQ ID NO:21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 , an amino acid sequence set forth in SEQ ID NO:51,52, 53, 54, 55, 56, 57, 58, 59, or 60, and/or a nucleotide sequence or an amino acid sequence set forth in SEQ ID NOs:2261-3808, including fragments thereof (e.g., functional fragments thereof) and variants thereof

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In certain embodiments, the olfactory receptor for use in the presently disclosed subject matter can include a receptor encoded by a nucleotide sequence that is at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98% or at least 99% homologous to any one of SEQ ID NOs:l 1-30 and/or a nucleotide sequence set forth in SEQ ID NOs:61-3808, (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor for use in the presently disclosed methods can include a receptor comprising an amino acid sequence that is between about 33 and 99%, between about 34 and 99%, between about 35 and 99%, between about 40 and 99%, between about 45 and 99%, between about 50 and 99%, between about 55 and 99%, between about 60 and 99%, between about 61 and 99%, between about 65 and 99%, between about 70 and 99%, between about 72 and 99%, between about 75 and 99%, between about 79 and 99%, between about 80 and 99%, between about 84 and 99%, between about 85 and 99%, between about 87 and 99%, between about 89 and 99%, between about 90 and 99%, between about 95 and 99%, or between about 97 and 99% homologous to any one of SEQ ID NOs: 41-60 and/or an amino acid sequence set forth in SEQ ID NOs:61-3808, (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor for use in the presently disclosed methods can include a receptor comprising an amino acid sequence that is at least about 33%, 34%, 35%, 40%, 45%, 50%, 55%, 60%, 61%, 65%, 70%, 72%, 75%, 79%, 80%, 84%, 85%, 87%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% homologous to any one of SEQ ID NOs:41-60 and/or an amino acid sequence set forth in SEQ ID NOs:61-3808, (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g,, functional fragments thereof).

In certain embodiments, the olfactory receptor is a canine CafaOR9.2.9 comprising an amino acid sequence as set forth in SEQ ID NO:41, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO: 31, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto

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PCT/US2017/054620 (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

in certain embodiments, the olfactory receptor is a canine CafaOR38.1.21 comprising an amino acid sequence as set forth in SEQ ID NO:42, or a sequence at least

99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO: 12, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as

BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a canine CafaOR21.2.15 comprising an amino acid sequence as set forth in SEQ ID NO:43, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO: 13, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a canine CafaOR21.2.43 comprising an amino acid sequence as set forth in SEQ ID NO:44, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO: 14, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a canine CafaOR15.2.20 comprising an amino acid sequence as set forth in SEQ ID NO:45, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NOT 5, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

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In certain embodiments, the olfactory receptor is a canine CafaOR 18.3.11 comprising an amino acid sequence as set forth in SEQ ID NO:46, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO: 16, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a canine CafaORl5.3.1 comprising an amino acid sequence as set forth in SEQ ID NO:47, ora sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO:17, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a canine CafaOR6.3.1 comprising an amino acid sequence as set forth in SEQ ID NO:48, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO: 18, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a canine CafaORl 8.3.12 comprising an amino acid sequence as set forth in SEQ ID NO:49, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO: 19, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a canine CafaOR5,2.5 comprising an amino acid sequence as set forth in SEQ ID NO:50, or a sequence at least

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99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO.20, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g,, functional fragments thereof).

In certain embodiments, the olfactory receptor is a feline EL13347030-13347977 comprising an amino acid sequence as set forth in SEQ ID NO:51, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO:21, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a feline FI :65134904-65135858 comprising an amino acid sequence as set forth in SEQ ID NO:52, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO:22, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a feline DI :62955839-62956792 comprising an amino acid sequence as set forth in SEQ ID NO:53, or a sequence at least 99, 98, 97, 96,95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO:23, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a feline DI :63312327-63313289 comprising an amino acid sequence as set forth in SEQ ID NO:54, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and

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PCT/US2017/054620 is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO:24, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, maybe measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a feline B3:72908295-72909287 comprising an amino acid sequence as set forth in SEQ ID NO:55, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO:25, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that tenn is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a feline DI :105486528105487493 comprising an amino acid sequence as set forth in SEQ ID NO:56, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, maybe measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO:26, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a feline B3:74116955-74117893 comprising an amino acid sequence as set forth in SEQ ID NO:57, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO:27, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a feline E3:40237904-40238842 comprising an amino acid sequence as set forth in SEQ ID NO:58, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID

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NO.28, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, maybe measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a feline DI: 105462554105463512 comprising an amino acid sequence as set forth in SEQ ID NO:59, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO:29, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, the olfactory receptor is a feline DI :21266824-21267768 comprising an amino acid sequence as set forth in SEQ ID NO:60, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), and is encoded, for example, by a nucleic acid comprising a sequence as set forth in SEQ ID NO:30, or a sequence at least 99, 98, 97, 96, 95, 90, 85 or 80 percent homologous thereto (homology, as that term is used herein, may be measured using standard software such as BLAST or FASTA), including fragments thereof (e.g., functional fragments thereof).

In certain embodiments, homology is described as a percent identity between two sequences. The percent identity of two amino acid sequences or of two nucleotide sequences can be determined by aligning the sequences for optimal comparison purposes (e.g., gaps can be introduced in the first sequence for best alignment with the sequence) and comparing the amino acid residues or nucleotides at corresponding positions. The percent identity can be determined by the number of identical amino acid residues or nucleotides in the sequences being compared (e.g., % identity = number of identical positions/total number of positions x 100).

In certain embodiments, a fragment of an olfactory receptor (e.g., functional fragments thereof) comprises at least about 5, about 10, about 15, about 20, about 25, about 30, about 40, about 50, about 60, about 70, about 80, about 90, about 100, about 125, about 150, about 175, about 200, about 250, about 300 or more amino acid residues, or any intermediate value or range thereof. In certain embodiments, the fragment comprises between about 5 to about 10, about 5 to about 20, about 5 to about 30, about 5

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PCT/US2017/054620 to about 40, about 5 to about 50, about 10 to about 50, about 10 to about 60, about 10 to about 70, about 10 to about 80, about 10 to about 90, about 10 to about 100, about 20 to about 100, about 50 to about 100, about 50 to about 150, about 50 to about 200, about 50 to about 250, about 100 to about 250, or about 100 to about 300 amino acid residues, or any intermediate range thereof.

The determination of percent identity between two sequences can be determined using a mathematical algorithm known to those of skill in the art. A non-limiting example of a mathematical algorithm for comparing two sequences is the algorithm of Karlin and Altschul (1990) Proc. Natl. Acad. Sci. USA 87:2264-2268, modified as in Karlin and Altschul (1993) Proc. Natl, Acad. Sci. USA 90:5873-5877, the disclosures of which are incorporated herein by reference in their entireties. The NBLAST and XBLAST programs of Altschul, et al. (1990) J. Mol. Biol. 215:403-410 have incorporated such an algorithm. BLAST nucleotide searches can be performed with the NBLAST program, for example, score = 100, wordlength ~ 12, to obtain nucleotide sequences homologous to nucleotide sequences of the invention. BLAST protein searches can be performed with the XBLAST program, for example, score = 50, wordlength - 3, to obtain amino acid sequences homologous to amino acid sequence of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al. (1997) Nucleic Acids Res. 25:3389-3402, the disclosure of which is incorporated herein by reference in its entirety. Alternatively, PSI-Blast can be used to perform an iterated search, which detects distant relationships between molecules. When utilizing BLAST, Gapped BLAST, and PSI-Blast programs, the default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used. See http://www.ncbi.nlm.nih.gov. An additional non-limiting example of a mathematical algorithm utilized for the comparison of sequences is the algorithm of Myers and Miller, CABIOS (1989), the disclosure of which is incorporated herein by reference in its entirety. The ALIGN program (version 2.0), which is part of the CGC sequence alignment software package, has incorporated such an algorithm. Other nonlimiting examples of algorithms for sequence analysis known in the art include ADVANCE and ADAM as described in Torellis and Robotti (1994) Comput. Appl. Biosci., 10:3-5; and FASTA described in Pearson and Lipman (1988) Proc. Natl. Acad. Sci. 85:2444-8, the disclosures of which are incorporated herein by reference in their entireties. Within FASTA, ktup is a control option that sets the sensitivity and speed of the search.

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In certain embodiments, the disclosed subject matter provides for the use of an isolated or purified olfactory receptor and/or variants and fragments thereof. The disclosed subject matter also encompasses the use of sequence variants. In certain embodiments, variation can occur in either or both the coding and non-coding regions of a nucleotide sequence of an olfactory receptor. Variants can include a substantially homologous protein encoded by the same genetic locus in an organism, i.e., an allelic variant. Variants also encompass proteins derived from other genetic loci in an organism, e.g., human, canine and feline but having substantial homology to the olfactory receptor, i.e., a homolog. Variants can also include proteins substantially homologous to the olfactory receptor but derived from another organism, i.e., an ortholog. Variants also include proteins that are substantially homologous to the olfactory receptor that are produced by chemical synthesis. Variants also include proteins that are substantially homologous to the olfactory receptor that are produced by recombinant methods.

Orthologs, homologs and allelic variants can be identified using methods well known in the art. These variants can include a nucleotide sequence encoding a receptor that is at least about 60-65%, about 65-70%, about 70-75, about 80-85%, about 90-95%, about 95-99% or more homologous to the nucleotide sequence shown in any one of SEQ ID NOs:l 1-30, or any one of nucleotide sequences in SEQ ID NOs:61-3808., or fragments thereof. Such nucleic acid molecules can readily be identified as being able to hybridize under stringent conditions, to the nucleotide sequence shown in any one of SEQ ID NOs: 11 -30, or any one of nucleotide sequences in SEQ ID NOs:61 -3808., or a fragment thereof. In certain embodiments, two polypeptides (or regions thereof) are substantially homologous when the amino acid sequences are at least about 60-65%, about 65-70%, about 70-75, about 80-85%, about 90-95%, about 95-99% or more homologous to the amino acid sequences shown in any one of SEQ ID NOs:41-60, or any one of amino acid sequences in SEQ ID NOs:61-3808,, or a fragment thereof. A substantially homologous amino acid sequence, according to the disclosed subject matter, will be encoded by a nucleic acid sequence hybridizing to the nucleic acid sequence, or portion thereof, of the nucleotide sequence shown in any one of SEQ ID NOs:41-60, or any one of amino acid sequences in SEQ ID NOs:61-3808., under stringent conditions.

The olfactory receptors for use in the methods of the disclosed subject matter include olfactory receptors having additions, deletions or substitutions of amino acid

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PCT/US2017/054620 residues (variants) which do not substantially alter the biological activity of the receptor. Those individual sites or regions of the olfactory receptors which may be altered without affecting biological activity can be determined by examination of the structure of the olfactory receptor extracellular domain, for example. Alternatively and/or additionally, one can empirically determine those regions of the receptor which would tolerate amino acid substitutions by alanine scanning mutagenesis (Cunningham et al., Science 244,

1081 -1085 (1989), the disclosure of which is hereby incorporated by reference in its entirety). In the alanine scanning mutagenesis method, selected amino acid residues are individually substituted with a neutral amino acid (e.g., alanine) in order to determine the effects on biological activity.

it is generally recognized that conservative amino acid changes are least likely to perturb the structure and/or function of a polypeptide. Accordingly, the disclosed subject matter encompasses one or more conservative amino acid changes within an olfactory receptor. Conservative amino acid changes generally involve substitution of one amino acid with another that is similar in structure and/or function (e.g., amino acids with side chains similar in size, charge and shape). Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine, tryptophan), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). In certain embodiments, one or more amino acid residues within an olfactory receptor can be replaced with other amino acid residues from the same side chain family and the altered protein can be tested for retained function using the functional assays described herein. Modifications can be introduced into an olfactory receptor of the present disclosure by standard techniques known in the art, such as sitedirected mutagenesis and PCR-mediated mutagenesis. If such substitutions result in retention in biological activity, then more substantial changes can be introduced and/or other additions/deletions may be made and the resulting products screened. In certain embodiments, deletions or additions can be from 5-10 residues, alternatively from 2-5 amino acid residues or from 1-2 residues, and values in between.

The presently disclosed subject matter also provides isolated nucleic acids encoding olfactory receptors, including fragments thereof (e.g., functional fragments

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PCT/US2017/054620 thereof). The olfactory receptors of the present disclosure can include mammalian olfactory receptors such as, but not limited to, human, canine and feline olfactory receptors. The isolated nucleic acids can be genomic DMAs, cDNAs and RNAs (e.g., mRNAs) in certain non-limiting embodiments, the olfactory receptor is a canine olfactory receptor, for example, canine olfactory receptor CafaOR9.2.9, CafaOR38.1.21, CafaOR21.2.15, CafaOR21.2.43, CafaORl 5.2.20, CafaORl8.3.11, CafaORl5.3.1, CafaOR6.3.1, CafaORl 8.3.12, CafaOR5.2.5, including fragments thereof (e.g., functional fragments thereof), or combinations thereof. In certain embodiments, the olfactory receptor comprises a nucleotide sequence set forth in SEQ ID NO: 11, 12, 13, 14, 15, 16, 17, 18,19, or 20, including fragments thereof (e.g., functional fragments thereof). In certain embodiments, the olfactory receptor comprises a nucleotide sequence set forth in SEQ ID NOs:61-2260,, including fragments thereof (e.g., functional fragments thereof).

In certain non-limiting embodiments, the olfactory receptor is a feline olfactory receptor, for example, feline olfactory receptor El :13347030-13347977 , FI :6513490465135858 , DI:62955839-62956792 , DI :63312327-63313289 , B3:72908295-72909287 ,01:105486528-105487493 ,B3:74116955-74117893 , E3:40237904-40238842 , Dl:105462554-105463512 , DT.21266824-21267768, including fragments thereof (e.g., functional fragments thereof), or combinations thereof. In certain embodiments, the olfactory receptor comprises a nucleotide sequence set forth in SEQ ID NO: 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30, including fragments thereof (e.g., functional fragments thereof). In certain embodiments, the olfactory receptor comprises a nucleotide sequence set forth in SEQ ID NOs:2261 -3808, including fragments thereof (e.g., functional fragments thereof).

The disclosed subject matter also provides for fusion proteins that comprise an olfactory receptor, or fragment thereof. In certain embodiments, the disclosed subject matter provides for fusion proteins of an olfactory receptor, or functional fragments thereof, and an immunoglobulin heavy chain constant region. In certain embodiments, a fusion protein of the present disclosure can include a detectable marker, a functional group such as a carrier, a label, a stabilizing sequence or a mechanism by which olfactory receptor agonist binding can be detected. Non-limiting embodiments of a label include a FLAG tag, a His tag, a MYC tag, a maltose binding protein and others known in the art. The presently disclosed subject matter also provides nucleic acids

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PCT/US2017/054620 encoding such fusion proteins, vectors containing fusion protein-encoding nucleic acids and host cells comprising such nucleic acids or vectors. In certain embodiments, fusions can be made at the amino terminus (N-terminus) of an olfactory receptor or at the carboxy terminus (C-terminus) of an olfactory receptor.

In certain embodiments, the olfactory receptors disclosed herein can contain additional amino acids at the N-terminus and/or at the C-tenninus end of the sequences, e.g., when used in the methods of the disclosed subject matter. In certain embodiments, the additional amino acids can assist with immobilizing the polypeptide for screening purposes, or allow the polypeptide to be part of a fusion protein, as disclosed above, for ease of detection of biological activity.

3. Methods for Identifying Olfactory Receptor Modulating Compounds

The present disclosure further provides methods for identifying compounds that modulate the activity and/or expression of an olfactory receptor. For example, and not by way of limitation, the modulator can be an agonist (for example, a full or partial agonist), or an antagonist, or an inverse agonist, or an allosteric modulator. The presently disclosed subject matter provides in silico and in vitro methods for identifying compounds that modulate the activity and/or expression of an olfactory receptor, disclosed above.

3.1 In silico Methods

The presently disclosed subject matter further provides in silico methods for identifying compounds that can potentially interact with an olfactory receptor and/or modulate the activity and/or expression of an olfactory receptor.

In certain embodiments, the method can include predicting the three-dimensional structure (3D) of an olfactory receptor and screening the predicted 3D structure with putative olfactory receptor modulating compounds (i.e., test compounds). The method can further include predicting whether the putative compound would interact with the binding site of the receptor by analyzing the potential interactions with the putative compound and the amino acids of the receptor. The method can further include identifying a test compound that can bind to and/or modulate the biological activity of the olfactory receptor by determining whether the 3D structure of the compound fits within the binding site of the 3D structure of the receptor.

In certain embodiments, the olfactory receptor for use in the disclosed method can be a canine receptor CafaOR9.2.9, CafaOR38.1.21, CafaOR21.2.15, CafaOR21.2.43, CafaOR 15.2.20, CafaOR 18.3.11, CafaOR15.3.1, CafaOR6.3.1, CafaOR18.3.12,

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CafaOR5.2.5, or combinations thereof. In certain non-limiting embodiments, the olfactory receptor is a canine olfactory receptor described in SEQ ID NOs :61-2260.

In certain embodiments, the olfactory receptor for use in the disclosed method can be a feline receptor El :13347030-13347977, FI :65134904-65135858, DI :6295583962956792, DI :63312327-63313289, B3:72908295-72909287, DI :105486528105487493, B3:74116955-74117893, E3:40237904-40238842, DI:105462554105463512, and DI :21266824-21267768, or combinations thereof. In certain nonlimiting embodiments, the olfactory receptor is a feline olfactory receptor described in SEQ ID NOs:2263-3808.

In other embodiments, the olfactory receptor for use in the disclosed method can have the amino acid sequence of any one of SEQ ID NO:41 -60, or any one of amino acid sequences in SEQ ID NOs:61-3808, or a fragment or variant thereof. In certain embodiments, the olfactory receptor for use in the presently disclosed subject matter can include a receptor comprising an amino acid sequence having at least about 33%, 34%, 35%, 40%, 45%, 50%, 55%, 60%, 61%, 65%, 70%, 72%, 75%, 79%, 80%, 84%, 85%, 87%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to any one of SEQ ID NO:41-60, or any one of amino acid sequences in SEQ ID NOs:61-3808, or a fragment or variant thereof. In certain embodiments, the olfactory receptor for use in the disclosed method can be encoded by a nucleotide sequence of any one of SEQ ID NO:11-30, or any one of nucleotide sequences in SEQ ID NOs:61-3808, or a fragment or variant thereof. In certain embodiments, the olfactory receptor for use in the presently disclosed subject matter can include a receptor encoded by a nucleotide sequence having at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98% or at least 99% identity to any one of SEQ ID NO:11-30, or any one of nucleotide sequences in SEQ ID NOs:61-3808, or a fragment or variant thereof.

Non-limiting examples of compounds (e.g., potential olfactory receptor modulators) that can be tested using the disclosed methods include any small chemical compound, or any biological entity, such as peptides, salts, amino acids and odor compound known in the art, e.g. androstenone. In certain embodiments, the test compound can be a small chemical molecule.

In certain embodiments, structural models of an olfactory receptor can be built using crystal structures of other GPCRs as templates for homology modeling. For example, and not by way of limitation, structural models can be generated using the

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PCT/US2017/054620 crystal structures of GPCRs. In certain embodiments, a structural model of an olfactory receptor can be based on a known or a combination of known crystal structures of GPCRs. (See, e.g., Lee et al., Eur J Pharmacol. 2015 May 14. pii: S00142999( 15)30012-1, which is incorporated by reference in its entirety herein). In certain embodiments, a structural model of an olfactory receptor can be generated based on the crystal structure of a β2 adrenergic receptor, 3SN6 from Protein Data Bank (PDB). (See, e.g., Rasmussen et al., Nature. 2011 Jul 19;477(7366):549-55, which is incorporated by reference in its entirety herein). In certain embodiments, a structural model of the 7 transmembrane domain (7TM) of an olfactory receptor can be generated based on the crystal structures of existing GPCR crystal structure 3SN6 from PDB. In certain embodiments structural models of an olfactory receptor can be built using the I-TASSER Suite of programs (Yang et al., Nat Methods, 12: 7-8 (2015), which is incorporated by reference in its entirety herein) and Modeller (Eswar et al., Curr Protoc Bioinformatics, 15: 5.6.1 -5.6.30 (2006), which is incorporated by reference in its entirety herein), which is part of the DiscoveryStudio (DS) suite of programs from Accelrys (DiscoveryStudio (DS) is a suite of interactive modeling and simulation programs from the Accelrys corporation).

Any suitable modelling software known in the art can be used. In certain embodiments, the Modeller software package can be used to generate the threedimensional protein structure.

In certain embodiments, the in silico methods of identifying a compound that binds to an olfactory receptor comprises determining whether a test compound interacts with one or more amino acids of an olfactory receptor binding pocket, as described herein.

Compounds that are identified by the disclosed in silico methods can be further tested using the in vitro and in vivo methods disclosed herein,

3.2 Olfactory Receptor Transmembrane Compound Binding Site

The present application provides for methods of screening for compounds that modulate the activity of an olfactory receptor, for example, a canine or feline olfactory receptor, wherein the compounds interact with one or more amino acids of the olfactory receptor. In certain embodiments, the binding site of an olfactory receptor comprises amino acids within the 7TM domain of the receptor, and can be identified by generating an interaction map of the receptor using in silico modeling, as described herein. In one non-limiting example, the presence of an amino acid in the 7TM interaction map means

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PCT/US2017/054620 that the residue is in the vicinity of the ligand binding environment, an interacts with the ligand.

In certain embodiments, the interaction between a compound and one or more amino acids of the olfactory receptor described herein can comprise one or more hydrogen bond, covalent bond, non-covalent bond, salt bridge, physical interaction, and combinations thereof. The interactions can also be any interaction characteristic of a ligand receptor interaction known in the art. Such interactions can be determined by, for example, site directed mutagenesis, x-ray crystallography, x-ray or other spectroscopic methods, Nuclear Magnetic Resonance (NMR), cross-linking assessment, mass spectroscopy or electrophoresis, cryo-microscopy, displacement assays based on known agonists, structural determination and combinations thereof. In certain embodiments, the interactions are determined in silico, for example, by theoretical means such as docking a compound into a feline or canine olfactory receptor binding pocket as described herein, for example, using molecular docking, molecular modeling, molecular simulation, or other means known to persons of ordinary skill in the art.

In certain embodiments, the interaction between an amino acid in the 7TM interaction map and the ligand is a pi-pi interaction.

In certain embodiments, the interaction between an amino acid in the 7TM interaction map and the ligand is a hydrogen bond interaction.

In certain embodiments, the interaction between an amino acid in the 7TM interaction map and the ligand is a hydrophobic interaction.

In certain embodiments, the interaction between an amino acid in the 7TM interaction map and the ligand is a van de Waals interaction.

In certain embodiments, the amino acid in the 7TM interaction map is a polar amino acid, wherein the amino acid interacts with the ligand as a hydrogen bond donor and/or acceptor.

In certain embodiments, the interaction between a compound and one or more amino acids of the olfactory receptors described herein can comprises one or more hydrogen bond, covalent bond, non-covalent bond, salt bridge, physical interaction, and combinations thereof. The interactions can also be any interaction characteristic of a ligand receptor interaction known in the art. Such interactions can be determined by, for example, site directed mutagenesis, x-ray crystallography, x-ray or other spectroscopic methods, Nuclear Magnetic Resonance (NMR), cross-linking assessment, mass spectroscopy or electrophoresis, cryo-microscopy, displacement assays based on known

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PCT/US2017/054620 agonists, structural determination and combinations thereof. In certain embodiments, the interactions are determined in silico, for example, by theoretical means such as docking a compound into an olfactory receptor binding pocket using molecular docking, molecular modeling, molecular simulation, or other means known to persons of ordinary skill in the art.

In certain embodiments, the olfactory receptor is a canine olfactory receptor, for example, but not limited to, CafaOR9.2.9, CafaOR38.1.21, CafaOR21.2.15,

CafaOR21.2.43, CafaOR 15.2.20, CafaORl8.3.11, CafaORl 5.3.1, CafaOR6.3.1, CafaORl 8.3.12, or CafaOR5.2.5. In certain non-limiting embodiments, the olfactory receptor is a canine olfactory receptor described in SEQ ID NOs:61-2260.

In certain embodiments, the olfactory receptor is a feline olfactory receptor, for example, but not limited to, El:13347030-13347977, FI :65134904-65135858,

D1:62955839-62956792, D1:63312327-63313289, B3:72908295-72909287,

DI :105486528-105487493, B3:74116955-74117893, E3:40237904-40238842,

DI :105462554-105463512, or DI :21266824-21267768. In certain non-limiting embodiments, the olfactory receptor is a feline olfactory receptor described in SEQ ID NOs:2261-3808.

In certain embodiments, the compounds interact with one or more olfactory receptors described herein according to any combination of interactions described herein, for example, one, two, three or more of the interactions.

In certain embodiments, the compounds bind to at least one of the receptors described herein. In certain embodiment, the compounds bind selectively to only one of the receptors described herein.

In one embodiment, the olfactory receptor is a canine CafaOR9.2.9. In certain embodiments, the amino acid residues that the compounds interact with comprises CafaOR9.2.9 residue Gin 103, for example, by hydrogen bonding or salt bridge interactions, as exemplified by in silico modeling of Lilial in CafaOR9,2.9 (Figure 2). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise CafaOR9.2.9 residues Leu304, Lys275, Arg87,

Val81, Met84, Val279, Tyr262, Met209, Gly258, Vail 11, Tyr255, Thr282, Phel07 and/or Thr80, either alone or in conjunction with interactions to Gin 103 listed above, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals interactions, or hydrophobic interactions,as exemplified by in silico modeling of Lilial in CafaOR9,2.9 (Figure 2). Alternatively, or in addition, in

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PCT/US2017/054620 certain embodiments, the amino acids that the compounds interact with comprise any one, two, three or more of the CafaOR9.2.9 residues Glnl03, Leu 104, Lys275, Arg87, Val81, Met84, Val279, Tyr262, Met209, Gly258, Vail 11, Tyr255, Thr282, Phel07 and Thr80, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions, van der Waals, hydrophobic interaction or other interactions, as exemplified by in silico modeling of Lilial in CafaOR9,2.9 (Figure 2).

In one embodiment, the olfactory receptor is a canine CafaOR38.1.21. In certain embodiments, the amino acid residues that the compounds interact with comprises CafaOR38.1.21 residue Lys273, for example, by hydrogen bonding or salt bridge interactions, as exemplified by in silico modeling of p-Anisaldehyde in CafaOR38.1.21 (Figure 3). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise CafaOR38.1.21 residues Thr78, Leu82, Tyr260, Thr256, Tyr253 and/or Phel05, either alone or in conjunction with interactions to Lys273 listed above, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals interactions, or hydrophobic interactions,as exemplified by in silico modeling of p-Anisaldehyde in CafaOR38.1.21 (Figure 3). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise any one, two, three or more of the CafaOR38.1.21 residues Lys273, Thr78, Leu82, Tyr260, Thr256, Tyr253 and Phel05, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions, van der Waals, hydrophobic interaction or other interactions, as exemplified by in silico modeling of p-Anisaldehyde in CafaOR38.1.21 (Figure 3).

In one embodiment, the olfactory receptor is a canine CafaOR21.2.15. In certain embodiments, the amino acids that the compounds interact with comprise CafaOR21.2.15 residues Met83, Hisl07, llel06, Leul82, Asnl97, Gly201, Val204, Ser260, Phe256 and/or Leu273, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals interactions, or hydrophobic interactions, as exemplified by in silico modeling of (+) -menthol in CafaOR21.2.15 (Figure 4). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise any one, two, three or more of the CafaOR21.2.15 residues Metl03, Met83, Hisl07, Ilel06, Leul82, Asnl97, Gly201, Val204, Ser260, Phe256 and Leu273, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions, van der Waals, hydrophobic

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PCT/US2017/054620 interaction or other interactions, as exemplified by in silico modeling of (+) -menthol in CafaOR2i .2.15 (Figure 4).

In one embodiment, the olfactory receptor is a canine CafaOR21.2.43. In certain embodiments, the amino acids that the compounds interact with comprise

CafaOR21.2.43 residues Met80, Met88, Leul08, Ilel 11, Hisl 12, Thrl 15, Val209,

Val210, Thr213, Leu214, Val262, Ile263, Ser266,I3e281, Ala284, and/or Leu288, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals interactions, or hydrophobic interactions, as exemplified by in silico modeling of Androstadienone in CafaOR21.2.43 (Figure 5). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise any one, two, three or more of the CafaOR21.2.43 residues Asp285, Met80, Met88, Leul08, Ilel 11, Hisl 12, Thrl 15, Val209, Val210, Thr213, Leu214, Val262, Ile263, Ser266, Ile281, Ala284, and Leu288, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions, van der Waals, hydrophobic interaction or other interactions, as exemplified by in silico modeling of Androstadienone in CafaOR21.2.43 (Figure 5).

In one embodiment, the olfactory receptor is a feline catGr5 (B3:7290829572909287). in certain embodiments, the amino acid residues that the compounds interact with comprises catGr5 (B3:72908295-72909287) residue Tyr277, for example, by hydrogen bonding or salt bridge interactions, as exemplified by in silico modeling of isobuteric acid in catGr5 (B3:72908295-72909287) (Figure 6). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise catGr5 (B3:72908295-72909287) residues Phel 39, Pro 177, Leul80, Ilel 81,

Pro 199, Cys217, and/or Phe220, either alone or in conjunction with interactions listed above, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals interactions, or hydrophobic interactions, as exemplified by in silico modeling of isobuteric acid in catGr5 (B3:72908295-72909287) (Figure 6). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise any one, two, three or more of the CafaOR9.2.9 residues Tyr277, Lys290, Phel 19, Prol 77, Leul 80,

Ilel 81, Pro 199, Cys217, and Phe220, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions, van der Waals, hydrophobic interaction or other interactions, as exemplified by in silico modeling of isobuteric acid in catGrS (B3:72908295-72909287) (Figure 6).

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In one embodiment, the olfactory receptor is a feline catGr6 (DI :105486528105487493). In certain embodiments, the amino acid residues that the compounds interact with comprises catGr6 (DI: 105486528-105487493) residue Tyr265, for example, by hydrogen bonding or salt bridge interactions, as exemplified by in silico modeling of β-ionone in catGr6 (01:105486528-105487493) (Figure 7). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise catGr6 (DI :105486528-105487493) residues Phe88, Phel 11, Metl70, Met206, Cys261, Ile264, Ser279, Ile280, and/or Thr283, either alone or in conjunction with interactions listed above, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals interactions, or hydrophobic interactions, as exemplified by in silico modeling of β-ionone in catGrb (DI :105486528-105487493) (Figure 7). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise any one, two, three or more of the catGr6 (Dl:105486528-105487493) residues Hisl 12, Asn209, Tyr265, Phe88, Phel 11, Met 170, Met206, Cys261, Ile264, Ser279, Ile280, and Thr283, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions, van der Waals, hydrophobic interaction or other interactions, as exemplified by in silico modeling of β-ionone in catGr6 (DI :105486528-105487493) (Figure 7).

In one embodiment, the olfactory receptor is a feline catG7 (B3:7411695574117893). In certain embodiments, the amino acid residues that the compounds interact with comprises catG7 (B3:74116955-74117893) residues Met81, Tyr258, and Gln 100, for example, by hydrogen bonding or salt bridge interactions, as exemplified by in silico modeling of Amyl acetate in catG7 (B3:74116955-74117893) (Figure 8). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise catG7 (B3:74116955-74117893) residues Thr77, Lys269, Leul04, Thr276, Val277, His73, Val273 and/or Val78, either alone or in conjunction with interactions listed above, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals interactions, or hydrophobic interactions, as exemplified by in silico modeling of Amyl acetate in catG7 (B3:74116955-74117893) (Figure 8). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise any one, two, three or more of the catG7 (B3:74116955-74117893) residues Met81, Tyr258, Gln 100,

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Thr77, Lys269, Leu 104, Thr276, Val277, His73, Val273 and Val78, forexample, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions, van der Waals, hydrophobic interaction or other interactions, as exemplified by in silico modeling of Amyl acetate in catG7 (B3:74116955-74117893) (Figure 8).

In one embodiment, the olfactory receptor is a feline catG8 (E3:4023790440238842). In certain embodiments, the amino acids that the compounds interact with comprise catG8 (E3:40237904-40238842) residues LeulOl, Phel04, Leul05, Glyl08, Glul80, Val202, Phe206, Tyr259, and/or Lys272, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals interactions, or hydrophobic interactions, as exemplified by in silico modeling of 1 nonanethiol in catG8 (E3:40237904-40238842) (Figure 9). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise any one, two, three or more of the catG8 (E3:40237904-40238842) residues Met81, LeulOl, Phel 04, Leu 105, Glyl08, Glut 80, Val202, Phe206, Tyr259, and Lys272, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions, van der Waals, hydrophobic interaction or other interactions, as exemplified by in silico modeling of 1-nonanethiol in catGS (E3:40237904-40238842) (Figure 9).

In one embodiment, the olfactory receptor is a feline catG9 (DI: 105462554105463512). In certain embodiments, the amino acid residues that the compounds interact with comprises catG9 (DI :105462554-105463512) residue Lys278, for example, by hydrogen bonding or salt bridge interactions, as exemplified by in silico modeling of β-ionone in catG9 (DI :105462554-105463512) (Figure 10). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise catG9 (DI:105462554-105463512) residues Phel 10, Vail 11, Glyl 14, Val208, Ile212, Phe258, Ala261, Leu262, Tyr265, Val282, and/or Ser285, either alone or in conjunction with interactions listed above, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals interactions, or hydrophobic interactions, as exemplified by in silico modeling of βionone in catG9 (DI :105462554-105463512) (Figure 10). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise any one, two, three or more of the catG9 (DI :105462554-105463512) residues Tyr79, Lys278, Phel 10, Vail 11, Glyl 14, Val208, Ile212, Phe258, Ala261, Leu262, Tyr265, Val282, and Ser285, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions, van der Waals, hydrophobic interaction

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PCT/US2017/054620 or other interactions, as exemplified by in silico modeling of β-ionone in catG9 (DI :105462554-105463512) (Figure 10).

In one embodiment, the olfactory receptor is a canine CafaOR5.2.5. In certain embodiments, the amino acids that the compounds interact with comprise CafaOR5.2.5 residues Tyr77, Phel08, Vail 12, Seri 16, Val206, Asp210, Phe256, and/or Thr283, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, charged interactions, van der Waals interactions, or hydrophobic interactions, as exemplified by in silico modeling of Coumarin in CafaOR5.2.5 (Figure 11). Alternatively, or in addition, in certain embodiments, the amino acids that the compounds interact with comprise any one, two, three or more of the CafaOR5.2.5 residues Tyr263, Tyr77, Phel08, Vail 12, Seri 16, Val206, Asp210, Phe256, and Thr283, for example, by polar, ring stacking, salt bridges, hydrogen bonding, pi interactions, or charged interactions, van der Waals, hydrophobic interaction or other interactions, as exemplified by in silico modeling of Coumarin in CafaOR5.2.5 (Figure 11),

In certain embodiments, the compounds interact with any one or more of the human, canine, or feline olfactory receptors described herein, wherein the compounds interact with one or more amino acid residues present in the 7TM domains of said receptors. The EC2 loop of said receptors is at the entrance to the active site pocket of the receptors. In certain embodiments, amino acid residues present in the EC2 loop of the olfactory receptors interact with the compounds described herein.

3.3 In vitro Methods

The presently disclosed subject matter further provides in vitro methods for identifying raw materials for generating pet food, food products, or compounds that can modulate the activity and/or expression of an olfactory receptor.

Olfactory receptors for use in the presently disclosed methods can include isolated or recombinant olfactory receptors or cells expressing an olfactory receptor, disclosed herein. In certain embodiments, the olfactory receptor for use in the disclosed methods can comprise the amino acid sequence of any one of SEQ ID NO:41-60, or any one of amino acid sequences in SEQ ID NOs:61-3808,or a fragment or variant thereof.

In certain embodiments, the olfactory receptor for use in the disclosed method can have at least about 33%, 34%, 35%, 40%, 45%, 50%, 55%, 60%, 61%, 65%, 70%, 72%, 75%, 79%, 80%, 84%, 85%, 87%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to the amino acid sequence of any one of SEQ ID NO:41-60, or any one of amino acid sequences in SEQ ID NOs:61 -3808, or a fragment or variant thereof. In

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PCT/US2017/054620 certain embodiments, the olfactory receptor for use in the disclosed method can be encoded by a nucleotide sequence comprising any one of SEQ ID NO: 11-30, or any one of nucleotide sequences in SEQ ID NOs:61-3808, or a fragment or variant thereof. In certain embodiments, the olfactory receptor for use in the presently disclosed subject matter can include a receptor encoded by a nucleotide sequence having at least 85%, at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98% or at least 99% identity to any one of SEQ ID NO: 11-30, or any one of nucleotide sequences in SEQ ID NOs:61-3808, or a fragment or variant thereof.

In certain embodiments, the method for identifying compounds that modulate the activity and/or expression of an olfactory receptor comprises measuring the biological activity of an olfactory receptor in the absence and/or presence of a test compound. In certain embodiments, the method can include measuring the biological activity of an olfactory receptor in the presence of varying concentrations of the test compound. The method can further include identifying the test compounds that result in a modulation of the activity and/or expression of the olfactory receptor compared to the activity and/or expression of the olfactory receptor in the absence of the test compound.

In certain embodiments, the method can further include analyzing two or more, three or more or four or more test compounds in combination, in certain embodiments, the two or more, three or more or four or more test compounds can be from different classes of compounds, e.g., amino acids and small chemical compounds. For example, and not by way of limitation, the method can include analyzing the effect of one or more small chemical test compounds on the biological activity and/or expression of an olfactory receptor in the presence of one or more amino acid test compounds. In certain embodiments, the method for identifying the effect of a compound on the activity and/or expression of an olfactory receptor comprises analyzing the effect of a test compound on the biological activity and/or expression of an olfactory receptor in the presence of an olfactory receptor ligand, for example, an odorant or olfactory receptor agoni st/antagoni st.

In certain embodiments, the method for identifying compounds that can modulate the activity and/or expression of an olfactory receptor comprises expressing an olfactory receptor in a cell line and measuring the biological activity of the receptor in the presence and/or absence of a test compound. The method can further comprise identifying test compounds that modulate the activity of the receptor by determining if

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PCT/US2017/054620 there is a difference in receptor activation in the presence of a test compound compared to the activity of the receptor in the absence of the test compound. In certain embodiments, the method can include measuring the biological activity of the olfactory receptor in the presence of varying concentrations of the test compound. In certain embodiments, the selectivity of the putative olfactory receptor modulator can be evaluated by comparing its effects on other GPCRs or olfactory receptors.

In certain embodiments, the compounds identified according to the methods described herein increase or decrease the biological activity of an olfactory receptor by at least about 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 100%, or more, compared to the biological activity of the olfactory receptor when the compound is not present.

In certain embodiments, the method for identifying compounds that modulate the activity and/or expression of an olfactory receptor comprises determining whether a compound modulates the receptor directly, for example, as an agonist or antagonist. In certain embodiments, the method comprises determining whether a compound indirectly modulates the activity of the receptor (e.g., as an allosteric modulator), for example, by enhancing or decreasing the effect of other compounds on activating or inhibiting receptor activity.

In certain embodiments, the test agent that can modulate the activity and/or expression of an olfactory receptor has an EC50 value of no more than about 200 μΜ. In certain embodiments, the test agent has an EC50 value of no more than about 1 μΜ, 2 μΜ, 3 μΜ, 4 μΜ, 5 μΜ, 6 μΜ, 7 μΜ, 8 μΜ, 9 μΜ, 10 μΜ, 20 μΜ, 30 μΜ, 40 μΜ, 50 μΜ, 60 μΜ, 70 μΜ, 80 μΜ, 90 μΜ, 100 μΜ, 110 μΜ, 120 μΜ, 130 μΜ, 140 μΜ, 150 μΜ, 160 μΜ, 170 μΜ, 180 μΜ, 190 μΜ or 200 μΜ. In certain embodiments, the test agent has an EC50 value of no more than about 250 μΜ, 300 μΜ, 400 μΜ, 500 μΜ, 600 μΜ, 700 μΜ, 800 μΜ, 900 μΜ or 1 Μ. In certain embodiments, the test agent has an EC50 value of at least 1 pM, 10 pM, 100 pM, 1 nM, 10 nM, or 100 nM, but no more than about 1 μΜ, 2 μΜ, 3 μΜ, 4 μΜ, 5 μΜ, 6 μΜ, 7 μΜ, 8 μΜ, 9 μΜ, 10 μΜ, 20 μΜ, 30 μΜ, 40 μΜ, 50 μΜ, 60 μΜ, 70 μΜ, 80 μΜ, 90 μΜ, 100 μΜ, 110 μΜ, 120 μΜ, 130 μΜ, 140 μΜ, 150 μΜ, 160 μΜ, 170 μΜ, 180 μΜ, 190 μΜ or 200 μΜ.

in certain embodiments, the test agent that can modulate the activity and/or expression of an olfactory receptor has an Emax value of no less than about 2.0. In certain embodiments, the test agent has an Emax value of no less than about 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5, 5.0, 5.5, 6.0, 6.5, 7.0, 7.5, 8.0, 8.5, 9.0, 9.5, 10, 15, 20,

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25, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140. 150 or 200. In certain embodiments, the test agent has an Emax value of more than about 200.

Activation of the receptor in the presently disclosed methods can be detected through the use of a labelling compound and/or agent. In certain embodiments, the activity of the olfactory receptor can be determined by the detection of secondary messengers such as, but not limited to, cAMP, cGMP, IP3, DAG or calcium. In certain embodiments, the activity of the olfactory receptor can be determined by the detection of the intracellular calcium levels. Monitoring can be by way of, but not limited to, luminescence or fluorescence detection, such as by a calcium sensitive fluorescent dye or luminescent pbotoprotein. In certain embodiments, monitoring can be by way of luminescence. In certain embodiments, the intracellular calcium levels can be determined using a cellular dye, e.g., a fluorescent calcium indicator such as Calcium 4. In certain embodiments, the intracellular calcium levels can be determined by measuring the level of calcium binding to a calcium-binding protein, for example, calmodulin. Alternatively and/or additionally, the activity of the olfactory receptor can be determined by the detection of the phosphorylation, transcript levels and/or protein levels of one or more downstream protein targets of the olfactory receptor. In certain embodiments, the Gio Sensor™ and/or protein kinase A (PKA)-NanoBiT™ technologies are used to determine the activity of an olfactory receptor. In certain embodiments, chAMPion assay system are used to determine the activity of an olfactory receptor, which measures cAMP levels indirectly via calcium influx through cyclic nucleotide gated (CNG) channels. In certain embodiments, GloSensor assay comprises transient co-transfection of OR plasmid and GloSensor plasmid and detection of cAMP by GloSensor (pemiutated luciferase, luminescence activity depends on binding of cAMP); luminescence read-out. In certain embodiments, PKA-NanoBiT assay comprises transient co-transfection of OR plasmid with PKA-NanoBiT plasmids and detection of a decrease of fluorescence and/or luminescence read-out (OFF signal) resulting from cAMP-dependent dissociation of PKA subunits which disrupts split-luciferase complementation. In certain embodiments, chAMPion assay comprises transient transfection of OR plasmid and detection of calcium through photoprotein or fluorescent dye, resulting from increased cAMP level which leads to opening of CNG channel and calcium influx.

The cell line used in the presently disclosed methods can include any cell type that is capable of expressing an olfactory receptor (e.g., stable or transient expression).

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Non-limiting examples of cells that can be used in the disclosed methods include HeLa cells, Chinese hamster ovary cells (CHO cells), African green monkey kidney cells (COS cells), Xenopus oocytes, HEK-293 cells and murine 3T3 fibroblasts. In certain embodiments, the method can include expressing an olfactory receptor in HEK-293 cells. In certain embodiments, the method can include expressing an olfactory receptor in COS cells. In certain embodiments, the cells constitutively express the olfactory receptor. In certain embodiments, the cells transiently express the olfactory receptor. In another embodiment, expression of the olfactory receptor by the cells is inducible.

In certain embodiments, the cell expresses a calcium-binding photoprotein, a cyclic nucleotide gated (CNG) channel, a cAMP response element (CRE)-containing luciferase reporter, a GloSensor luciferase, or a PKA-NanoBiT system. In certain embodiments, the cell expresses a calcium-binding photoprotein, wherein the photoprotein luminesces upon binding calcium. In certain embodiments, the calciumbinding photoprotein comprises a compound selected from the group consisting of clytin, aequorin, obelin, any recombinant or isolated versions thereof, and combinations thereof, in certain embodiments, the calcium binding photoprotein comprises the protein clytin.

In certain embodiments the clytin is a recombinant clytin. In certain embodiments, the clytin comprises an isolated clytin, for example, a clytin isolated from Clytia gregarium. In certain embodiments, the calcium-binding photoprotein comprises the protein aequorin, for example, a recombinant aequorin or an isolated aequorin, such as an aequorin isolated from Aequorea victoria. In certain embodiments, the calcium-binding photoprotein comprises the protein obelin, for example, a recombinant obelin or an isolated obelin, such as an obelin isolated from Obelia longissima.

In certain embodiments, an intracellular calcium level is monitored by luminescence detection or fluorescence detection, in certain embodiments, the fluorescence detection comprises a calcium sensitive fluorescent dye selected from the group consisting of Fura-2 AM, Fura-2 pentapotassium, Fura Red AM, Indo-1 AM, Indo-1 pentapotassium, Fluo-3, Fluo-4, Fluo-8, Calcium Green-1, Calcium 3, Calcium 4, Calcium 5, Rhod-2, derivatives thereof and combinations thereof.

In certain embodiments, expression of an olfactory receptor in a cell can be performed by introducing a nucleic acid encoding an olfactory receptor into the cell. For example, and not by way of limitation, a nucleic acid having the nucleotide sequence set forth in any one of SEQ ID NO: 11-30, or any one of nucleotide sequences in SEQ ID NOs:61-3808, or a fragment thereof, can be introduced into a cell. In certain

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PCT/US2017/054620 embodiments, the introduction of a nucleic acid into a ceil can be earned out by any method known in the art, including but not limited to transfection, electroporation, microinjection, infection with a viral or bacteriophage vector containing the nucleic acid sequences, cell fusion, chromosome-mediated gene transfer, microcell-mediated gene transfer, spheroplast fusion, etc. Numerous techniques are known in the art for the introduction of foreign genes into cells (see, e.g., Loeffler and Behr, Meth. Enzymol. 217:599-618 (1993); Cohen et al., Meth. Enzymol. 217:618-644 (1993); Cline, Pharmac. Ther. 29:69-92 (1985), the disclosures of which are hereby incorporated by reference in their entireties) and can be used in accordance with the disclosed subject matter. In certain embodiments, the technique can provide for the stable transfer of the nucleic acid to the cell, so that the nucleic acid is expressible by the cell and inheritable and expressible by its progeny. In certain embodiments, the technique can provide for a transient transfer of the nucleic acid to the cell, so that the nucleic acid is expressible by the cell, wherein the concentration of the nucleic acid and the expression decrease in subsequent generations of the cell’s progeny.

In certain embodiments, the methods can include identifying compounds that bind to an olfactory receptor. The methods can comprise contacting an olfactory receptor with a test compound and measuring binding between the compound and the olfactory receptor. For example, and not by way of limitation, the methods can include providing an isolated or purified olfactory receptor in a cell-free system, and contacting the receptor with a test compound in the cell-free system to determine if the test compound binds to the olfactory receptor. In certain embodiments, the method can comprise contacting an olfactory receptor expressed on the surface of a cell with a candidate compound and detecting binding of the candidate compound to the olfactory receptor. The binding can be measured directly, e.g., by using a labeled test compound, or can be measured indirectly. In certain embodiments, the detection comprises detecting a physiological event in the cell caused by the binding of the compound to the olfactory receptor, e.g., an increase in the intracellular calcium levels. For example, and not by way of limitation, detection can be performed by way of fluorescence detection, such as a calcium sensitive fluorescent dye, by detection of luminescence, or any other method of detection known in the art.

In other non-limiting embodiments, the in vitro assay comprises cells expressing an olfactory receptor that is native to the cells. Examples of such cells expressing a native olfactory receptor include, for example but not limited to, human, dog and/or cat

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PCT/US2017/054620 olfactory cells (e.g., olfactory receptor cells). In certain embodiments, the human, dog and/or cat olfactory cells expressing an olfactory are isolated from a human dog and/or cat and cultured in vitro. In certain embodiments, the olfactory receptor cells can be immortalized, for example, such that the cells isolated from a human, dog and/or cat can be propagated in culture.

In certain embodiments, expression of an olfactory receptor in a cell can be induced through gene editing, for example, through use of the CRISPR gene editing system to incorporate an olfactory receptor gene into the genome of a cell, or to edit or modify an olfactory receptor gene native to the cell.

In certain embodiments, the in vitro methods of identifying a compound that binds to an olfactory receptor comprises determining whether a test compound interacts with one or more amino acids of an olfactory receptor binding pocket, as described herein.

in certain embodiments, compounds identified as modulators of an olfactory receptor can be further tested in other analytical methods including, but not limited to, in vivo assays, to confirm or quantitate their modulating activity.

In certain embodiments, the methods of identifying an olfactory receptor modulator can comprise comparing the effect of a test compound to an olfactory receptor agonist or antagonist. For example, a test compound that increases or decreases the activity of the receptor in the presence of an agonist when compared to the activity of the receptor when contacted with an olfactory receptor agonist alone can be selected as an olfactory receptor modulating compound.

Olfactory receptor agonists that can be used according to said methods can comprise one or more compounds described by Table 1.

Table 2. Compounds for Human (H) or Mouse (M) Olfactory Receptors

Olfactory Receptor Orthologues	Compounds
Human	Canine	Feline
HsOR17.1.1	CafaOR9.2.	El :13347030-	aldehyde TPM (H), cyclosa (H),
I (hOR3Al)	9	13347977 (CatGl)	foliaver (H), helional (H), filial (H), methyl-hydrocinnamaldehyde (H), methyl-phenyl-pentanal (H), trifemal (H)
HsORl.4.8	CafaOR38.	FI :65134904-	anisaldehyde (H)

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(I1OR6PI)	1.21	65135858 (CatG2)
HsORl 1.3.1	CafaOR21.	DI :62955839-	(+)-menthol (H), 2,4-DNT (H), 3-
4 (hOR51El)	2.15	62956792 (CatG3)	methyl-valeric acid (H), 4-methyl- valeric acid (H), butyl butyryl lactate (H), butyl butyryllactate (H), butyric acid (H), DMDS (H), eugenol methyl (H), eugenyl acetate (H), isovaleric acid (H), methyl furfuryl disulfide (H), methyl salicylate (H), nonanoic acid (H), pentanol (H), propanal (H), pyrazine (H)
HsORl 1.3.4	CafaOR21.	DI :63312327-	allyl phenylacetate (Ή),
0 (hOR51Ll)	2.43	63313289 (CatG4)	androstadienone (H), caproic acid (H), hexanoic acid (H), phenyl acetaldehyde (H)
HsOR14.1.2 7 (hORllH6)	CafaORl 5. 2.20	B3:72908295- 72909287 (CatG5)	isovaleric acid (H)
HsORll.13. 7 (hOR4D6)	CafaORl 8. 3.11	DI :105486528- 105487493 (CatG6)	beta-ionone (H)
HsOR 14.2.5 (hOR4E2)	CafaORl 5. 3.1	B3:74I16955- 74117893 (CatG7)	amyl acetate (H)
HsORl 6.1.3 (hOR2Cl)	CafaOR6.3. 1	E3:40237904- 40238842 (CatG8)	nonanethiol (H), octanethiol (H)
HsORll.13. 6 (hOR5Al)	CafaORl 8. 3.12	DI :105462554- 105463512 (CatG9)	beta-ionone (H)
HsORl 1.18. 36	CafaOR5.2. 5	DI :21266824- 21267768	acetophenone (M), coumarin (M)

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(hOR8B8) (CatGlO)

In certain embodiments, the olfactory receptor agonist is selected from the group consisting of trifemal, isovaleric acid, 3-methyl-2-hexanoic acid, alpha-ionone, hexyl acetate, amyl mercaptan, helional, para-anisaldehyde, 4-ethoxybenzaldehyde, menthol, methyl-eugenol, methyl-salicylate, phenylacetaldehyde, beta-ionone, amyl acetate, nonanethiol, acetophenone, coumarin, lilial, meta-anisaldehyde, 4-m ethyl-valeric acid, pentanol, allyl-phenylacetate, hexanoic acid, alpha-ionone, citral, isoamylacetate, octanethiol, propiophenone, 7-methoxycoumarin and combinations thereof.

In certain embodiments, the olfactory receptor modulators of the present disclosure comprise a salt of the olfactory receptor m odulator, for example, but not limited to, an acetate salt or a formate salt. In certain embodiments, the olfactory receptor modulator salt comprises an anion (-) (for example, but not limited to, Cf, O²‘, CO3², HCCfy, OH, NO3; PO₄ ³, SO4², CH3COO, HCOO and C₂O₄ ²') bonded via an ionic bond with a cation (+) (for example, but not limited to, Al³⁺, Ca²⁺, Na⁺, K⁺, Cu²⁺, H⁺, Fe³⁴, Mg²⁺, NH4⁴ and H3O ). In other embodiments, the olfactory receptor agonist salt comprises a cation (+) bonded via an ionic bond with an anion (-).

In certain embodiments, the olfactory receptor modulators of the present application are identified through in silico modeling of an olfactory receptor, e.g., a canine and/or feline olfactory receptor, wherein the olfactory receptor modulators of the present application comprise a structure that fits within a binding site of the olfactory receptor. In certain embodiments, the in silico method comprises the in silico methods described above and in the Examples section of the present application.

In certain embodiments, the olfactory receptor modulators of the present application are identified through an in vitro method, wherein the olfactory receptor modulator compounds modulate an olfactory receptor, disclosed herein, expressed by cells in vitro. In certain embodiments, the in vitro method comprises the in vitro methods described above and in the Examples section of the present application.

4. Pet Food Products

The present application provides for screening methods that can be used to identify suitable raw materials to produce a palatable and nutritious pet food product.

The presently disclosed screening methods can also be used to determine if a finished pet food product would be palatable to the pet (e.g., a dog or a cat). For example, the in vitro methods described herein can be used to screen raw materials and finished pet food

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PCT/US2017/054620 products to identify whether the raw materials or finished pet food products comprise compounds that increase, decrease, or modulate olfactory receptor activity and/or expression. In certain embodiments, raw materials and finished pet food products that do not increase the activity and/or expression of an olfactory receptor can be selected for use in, or as, a pet food product for consumption. In certain embodiments, raw materials and finished pet food products that do increase the activity and/or expression of an olfactory receptor can be selected for use in, or as, a pet food product for consumption.

Non-limiting examples of suitable pet food products include wet food products, dry food products, moist food products, pet food supplements (e.g., vitamins), pet beverage products, snack and treats and pet food categories described herein.

One of the goals of the pet care industry is to identify sustainable protein sources for pets that do not compete with the human food chain. As such, there is an ongoing search for novel protein sources that fit these criteria. The presently disclosed screening method can be used to identify which of the novel protein sources would be considered palatable to the pet, or at least have no effect on the palatability of the other ingredients of the pet food. In certain embodiments, the novel protein source (i.e., raw material) is meat, fish, cheese, beans, yeast, yeast extracts, bacteria, algae, fungi, nuts, seeds or other plant material, or combinations thereof. In certain embodiments, the raw material is meat.

In certain embodiments, the protein source can be derived from a variety of plant sources. Non-limiting examples of plant sources include com, maize, rice, soy, wheat, etc. For example, and not by way of limitation, the plant-derived protein can include lupin protein, wheat protein, soy protein and combinations thereof. Alternatively or additionally, the protein source can he derived from a variety of animal sources, for example, a multicellular eukaryotic organism from the kingdom animalia. Non-limiting examples of animal protein include beef, pork, poultry, lamb or fish including, for example, muscle meat, meat byproduct, meat meal or fish meal. Other non-limiting examples of animal sources include insects, or other organism from the phylum arthropods.

In certain embodiments, the protein source can be derived from yeast or any other single-cell eukaryotic organisms, mold, mushroom or fungi.

In certain embodiments, the protein source can be derived from bacteria, archaea, or any other archaebacteria, eubacteria, or prokaryotic organism.

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In certain embodiments, the protein source can be derived from algae, kelp, seaweed, or any other single or multicellular photosynthetic organism or protist.

In certain embodiments, the presently disclosed subject matter includes accepting or rejecting a raw material for the production of pet food based on the raw material’s ability to enhance, increase, decrease and/or modulate the activity and/or expression of an olfactory receptor.

In certain embodiments, the raw material is rejected if the raw material results in the enhancement or increase in the activity and/or expression of at least one olfactory receptor. In certain embodiments, the raw material is rejected if the raw material results in the enhancement or increase in the activity and/or expression of at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, at least ten, at least eleven, at least twelve, at least thirteen, at least fourteen, at least fifteen, and/or at least sixteen olfactory receptors.

In certain embodiments, the raw material is accepted if the raw material results in the enhancement or increase in the activity and/or expression of at least one olfactory receptor, in certain embodiments, the raw material is accepted if the raw material results in the enhancement or increase in the activity and/or expression of at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, at least ten, at least eleven, at least twelve, at least thirteen, at least fourteen, at least fifteen, and/or at least sixteen olfactory receptors.

In certain embodiments, the raw material is accepted if it does not modulate the activity of at least one olfactory receptor. In certain embodiments, the raw material is selected if it inhibits or blocks the activity and/or expression of at least one olfactory receptor.

In certain embodiments, the raw material is rejected if it does not modulate the activity of at least one olfactory receptor, in certain embodiments, the raw material is rejected if it inhibits or blocks the activity and/or expression of at least one olfactory receptor.

In certain embodiments, the olfactory receptor is selected from any one or more of canine receptors CafaOR9.2.9, CafaOR38.1.21, CafaOR21.2.15, CafaOR21.2.43, CafaORl 5.2.20, CafaORl8.3.11, CafaOR15.3.1, CafaOR6.3.1, CafaORl 8.3.12, and/or CafaOR5.2.5. In certain non-limiting embodiments, the olfactory receptor is selected from one or more of canine olfactory receptors described in SEQ ID NOs:61-2260.

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In certain embodiments, the olfactory receptor is selected from any one or more of feline receptors El :13347030-13347977, FI :65134904-65135858, DI :6295583962956792, D1:63312327-63313289, B3:72908295-72909287, D1:105486528105487493, B3:74116955-74117893, E3:40237904-40238842, DI :105462554105463512, and/or DI :21266824-21267768. In certain non-limiting embodiments, the olfactory receptor is selected from one or more feline olfactory receptors described in SEQ ID NOs:2261-3808.

in certain non-limiting embodiments, a raw material that results in the enhancement or increase in the activity and/or expression of at least one olfactory receptor can be admixed with a compound that inhibits or reduces the activity and/or expression of the at least one olfactory receptor, wherein the admixture is accepted for the production of pet food.

During the production of pet food, some of the materials may change form due to mechanical forces, thermal forces, or chemical reactions. The presently disclosed screening method can be used to identify pet food products that form compounds that are unpalatable to an animal, for example, a canine or a feline, for example, a compound that enhances or increases the activity and/or expression of an olfactory receptor.

In certain embodiments, the presently disclosed subject matter includes accepting or rejecting a pet food product based on the product’s ability to enhance, increase, decrease and/or modulate the activity and/or expression of an olfactory receptor.

In certain embodiments, the pet food product is rejected if the product results in the enhancement or increase in the activity and/or expression of at least one olfactory receptor. In certain embodiments, the pet food product is rejected if the product results in the enhancement or increase in the activity and/or expression of at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, at least ten, at least eleven, at least twelve, at least thirteen, at least fourteen, at least fifteen, and/or at least sixteen olfactory receptors. In certain embodiments, the pet food product is accepted if it does not modulate the activity of at least one olfactory receptor. In certain embodiments, the pet food product is selected if it inhibits or blocks the activity and/or expression of at least one olfactory receptor.

In certain embodiments, the pet food product is accepted if the product results in the enhancement or increase in the activity and/or expression of at least one olfactory receptor. In certain embodiments, the pet food product is accepted if the product results in the enhancement or increase in the activity and/or expression of at least two, at least

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PCT/US2017/054620 three, at least four, at least five, at least six, at least seven, at least eight, at least nine, at least ten, at least eleven, at least twelve, at least thirteen, at least fourteen, at least fifteen, and/or at least sixteen olfactory receptors. In certain embodiments, the pet food product is rejected if it does not modulate the activity of at least one olfactory receptor. In certain embodiments, the pet food product is rejected if it inhibits or blocks the activity and/or expression of at least one olfactory receptor.

The flavor compositions of the present disclosed subject matter can also be used in a wide variety of pet food products. The combination of the flavoring composition(s) of the presently disclosed subject matter together with a pet food product and optional ingredients, when desired, provides a flavoring agent that possesses unexpected odor and imparts, for example, a desirable olfactory sensory experience. The flavor compositions disclosed herein can be added prior to, during or after formulation processing or packaging of the pet food product, and the components of the flavor composition can be added sequentially or simultaneously.

In certain embodiments, the pet food product is a nutritionally complete dry, wet or semi-moist food product. A dry or low moisture-containing nutritionally-complete pet food product can comprise less than about 15% moisture. A wet or high moisturecontaining nutritionally-complete pet food product can comprise greater than about 50% moisture. Such food products can include from about 10% to about 90% fat, from about 10% to about 70% protein and from about 5% to about 80% carbohydrates, e.g., dietary fiber and ash, on a percent energy basis.

In certain embodiments, the pet food product is a nutritionally complete dry, wet or semi-moist food product. In certain embodiments, the pet food product includes from about 60% fat, from about 30% protein and from about 10% carbohydrates, e.g., dietary fiber and ash, on a percent energy basis.

In certain embodiments, the pet food product is a nutritionally complete moist food product. A moist, e.g., semi-moist or semi-dry or soft dry or soft moist or intermediate or medium moisture containing nutritionally-complete pet food product comprises from about 15 to about 50% moisture.

In certain embodiments, the pet food product is a non-nutritiona1ly-complete pet food products (e.g., snack, care and treats). In certain embodiments, the pet food product is a pet food snack product. Non-limiting examples of pet food snack products include snack bars, pet chews, crunchy treats, cereal bars, snacks, biscuits and sweet products.

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In certain embodiments of the present disclosure, the odor and/or palatability attributes of a pet food product or medicine prepared according to the methods described herein can be measured by an in vivo smelling method that uses a panelist of odor testers. For example, but not by way of limitation, the panel can contain canine and/or feline panelists. In certain embodiments, the palatability of a pet food product containing, for example, a screened raw material or a screened pet food product can be determined by the consumption of the pet food product alone (e.g., the one bowl test, monadic ranking). In certain embodiments, the palatability of a screened raw material or a screened pet food product can be detennined by the preferential consumption of the pet food product or raw material, versus a pet food product that is known to be palatable to the animal (e.g., the two bowl test for testing preference, difference and/or choice).

In certain embodiments, the palatability and/or repellant blocking odor of a compound identified according to the methods described herein can be determined by the preferential consumption of a water solution containing said compound versus a water solution that does not contain the compound or contains a different flavor composition, for example, an olfactory receptor agonist (e.g., the two bottle test). The intake ratio for each pet food product or water solution can be determined by measuring the amount of one ration consumed divided by the total consumption. The consumption ratio (CR) can then be calculated to compare the consumption of one ration in terms of the other ration to determine the preferential consumption of one food product or water solution over the other. Alternatively or additionally, the difference in intake (g) can be used to assess the average difference in intake between the two solutions in a two bottle test or between two pet food products in a two bowl test at a selected significance level, for example, at the 5% significance level to determine an average difference in intake with a 95% confidence interval. In certain embodiments, the confidence interval can be about 90%. However, any significance level may be used, for example, a 1,2, 3, 4, 5, 10, 15, 20, 25 or 50% significance level.

In certain embodiments, percentage preference scores, e.g., the percentage preference for one solution or food product by an animal, is the percentage of the total liquid or food product ingested during the test that that solution or food product accounts for, can also be calculated.

5. Odor Deterrents

The present disclosure provides methods for maintaining the health of an animal by imparting a repellant odor and/or decreasing the palatability of an object or surface.

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In certain embodiments, the method comprises applying, coating or contacting an odor deterrent product comprising a compound identified according to the methods described herein to the object or surface, and thereby preventing contact and/or ingestion of said object or surface by an animal. Accordingly, detrimental effects on the animal’s health that could result from contact and/or ingestion of said object or surface are avoided. In certain embodiments, the object or surface is harmful to the health of the animal or toxic to the animal.

EXAMPLES

The presently disclosed subject matter will be better understood by reference to the following Examples, which are provided as exemplary of the invention, and not by way of limitation.

Example 1 - in silico model of interactions between olfactory receptors and putative binding compounds

The present example describes the computational modeling of canine/feline olfactory receptors (ORs) to identify putative olfactory receptor modulators.

Homology models of canine/feline olfactory receptors were based on crystal structure of 3SN6 from Protein Data Bank (PDB). 3SN6 is the crystal structure of β2 adrenergic receptor from Group A GPCR with bound agonist (ΒΙΊ 67107 from Boehringer Ingelheim). (Rasmussen et al., Nature, 477: 549-555 (2011)). The models were built using the I-TASSER Suite of programs (Yang et al., Nat Methods, 12: 7-8 (2015)) and Modeller (Eswar et al., Curr Protoc Bioinformatics, 15: 5.6,1-5.6.30 (2006)), which is part of the DiscoveryStudio (DS) suite of programs from Accelrys (DiscoveryStudio (DS) is a suite of interactive modeling and simulation programs from the Accelrys corporation).

The odor compounds were docked into the active site of canine/feline olfactory receptors. The docking program BioDock from BioPredict, Inc., was used but other state of the art docking programs could be used for this purpose.

The results of in silico modeling are presented in Figures 2-11, Figure 13 shows a phylogenetic tree for multi-species (human/canine/feline) covering the olfactory genetic space. The phylogenetic tree shows all olfactory receptors, and that the 30 selected olfactory receptors (10 human receptors, 10 canine receptors, 10 feline receptors, highlighted, SEQ ID NO: 1-60) are evenly distributed around the olfactory genetic space.

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Figure 13 further shows the 10 pairs of canine/feline olfactory receptors (SEQ ID NO:11-30 and SEQ ID NO:41-60) were chosen because they cover an optimal breadth and range of the potential OR receptors.

Example 2 - Identification of canine and feline olfactory receptors

The dog olfactory receptor sequences and methods for detection were previously described by Niimura & Nei (2007) from which the 1,100 dog olfactory receptor sequences were obtained. The 774 putative cat olfactory receptor sequences were identified using a combination of previous annotations and similarity searches. The sequences for gene annotations containing “olfactory receptor” were extracted from the ensembl cat genome (Felis_catus_6.2 (GCA000181335.2)). In addition Dog, Human, Mouse, Elephant, Cow, Horse, Rabbit and Guinea Pig nucleotide sequences (Niimura et al., 2015) were used to search against the cat genome. The cat reference sequence was extracted for all unique alignments with >=65 percent identity and >=650 bp length. Redundant sequences (>=95% identity) were removed using longest first sequence clustering (Fu et ah, 2012) retaining only representatives. The amino acid translations for these representatives were identified using sixpack from the emboss package (Rice et al., 2000), selecting the longest amino acid sequence within an open reading frame.

The nucleic acid and amino acid sequences of the 1,100 dog olfactory receptors and 774 putative cat olfactory receptors are set forth in SEQ ID NOs:61-3808.

Example 3 -- Identification of canine and feline olfactory receptor modulators using in vitro assays.

This example refers to the functional expression of different feline and canine olfactory receptors (ORs). 20 OR sequences were selected, where 10 sequences have feline origins and the remaining 10 have canine origins. These ORs were subcloned into a modified expression vector suitable for the transient, functional expression of ORs. The transiently expressed receptors were then stimulated with various concentrations of different odorants aiming to deorphanize the feline and canine ORs. As illustrated in Figure 12, OR responsiveness was detected in either one or both of the following cell lines and assays: 1) HEK293 PEAKrapid/RTPls endo (reporter cell line A) and a CRENanoLuc luciferase reporter assay; and 2) HEK293/NatClytin/CNG/RTPls (reporter cell line B) endo and a CNG chAMPion assay. Functional expression of the different OR

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PCT/US2017/054620 sets were transient in reporter cell line A or B. The transiently transfected ORs were stimulated with 3 concentrations (n-4 ) of different odorants (at least 3).

Material and methods

Cell lines. The following cell lines were used for this project:

• Reporter cell line A (for CRE-Luciferase, GloSensor, and PKA-NanoBiT assays): HEK293 PEAKrapid/RTPls endo • Reporter cell line B (for chAMPion assay): HEK293/CNG/nat-Clytin/RTP 1 s endo

Cell culture media. Cells were maintained in DMEM High Glucose (Lonza Bio Whittaker cat. BE12-604F/U1; 500 mb) supplemented with fetal bovine serum (Sigma cat, F7524; final concentration 10%), penicillin-streptomycin (BioWhittaker cat. DEI 7-602E; 5 mL of 100X solution) and the following selection antibiotics:

• HEK293 PEAKrapid/RTPls endo: 0.1 mg/mL G418, 0.2 mg/mL hygromycin, 0.1 mg/mL zeocin.

• HEK293/CNG/nat-Clytin/RTPl s endo: 0.8 mg/mL G418, 50 pg/mL zeocin, 0.6 pg/mL puromycin.

Cell culture conditions. Cell lines were maintained in their respective complete culture media at 37°C, 5% CO2, and 90% humidity. Cells were split twice a week. Under standard propagation conditions, approx. 4x10⁶ cells were seeded in a T225 flask recovering about 30x10⁶ cells/flask. For splitting, cells were gently washed with PBS and then incubated with trypsin for 5 min at RT or 37°C. Media were added and cells were resuspended.

Buffers. Tyrode buffer with 0 mM calcium: in-house solution (130 mM NaCl, 5 mM KC1, 3 mM MgCl₂, 5 mM NaHCCfy 20 mM HEPES in water at pH 7.4; sterile filtered and autoclaved). Tyrode buffer: in-house solution (130 mM NaCl, 5 mM KC1, 1 mM MgCl₂, 5 mM NaHCOj, 2 mM CaCl₂, 20 mM HEPES in water at pH 7,4; sterile filtered and autoclaved). Tyrode buffer with 10 mM calcium: Tyrode buffer 0 mM calcium plus 10 mM CaCfr. Calcium chloride (dihydrate): Sigma, 223506, 1 M stock solution, prepared in water and stored at RT. Coelenterazine: stock solution: 5 mg/mL in DMSO (11.8 mM) with 30 pM glutathione; aliquoted and stored at -20°C; diluted 1:3000 in tyrode buffer for experiments (final concentration: 11.8 pM).

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OR sequences. The canine OR sequences SEQ ID NOs: 11-20 and the feline OR sequences SEQ ID NOs; 21-30 were used. These sequences were synthesized and cloned into a pcDNAS expression vector with an N-terminal SSTR3 transport tag.

OR ligands. OR and odorant combinations test in phase 2 are provided in Table

3.

Table 3.

ORs - human, dog, cat, (mouse)	Odorant	Structure
OR_1 (OR3A1)	Helional
Lilial
Trifemal
OR_2(OR6P1)	para-Anisaldehyde	0 Γ if
meta-Anisaldehyde	<VH
4- Ethoxyb enzaldehyde	V V HiC
OR 3 (ORS 1 El) (Odorants in gray shade were present in mixes but not tested individually)	Isovaleric acid	ch3 0 H3C'^x^'OH
4-M ethyl -valeric acid	0 ch3
3-Methyl-2-hexanoic acid	c .... .1 h,c ' y C
Hexaonic acid	0 X CHa(CH2)3CH2''^OH
	®®S B Hsc·· '0H ch3 ft®!®®
	Ii
	ΒΙΙβΙ Λτ-όη .βΙΒΙΙΟΙΙΙ
Pentanol ii/XXWX	ch3(ch2)3ch2oh I®

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OR_4(OR51L1)	Allyl phenylacetate	Qsj1 0
Hexanoic acid	o X CH3(CHi,)3CH2'' OH
Phenyl acetaldehyd e	o A Γ H o
OR 5 (OR11H6)	Isovaleric acid	ch3 0 μΑ *ΌΗ
4-Methyl-valeric acid	O E ΟΗ,ΟΜΗ/ ΟΗ
3-Methyl-2-hexanoic acid	,· j
OR 6 (OR4D6), OR 9 (OR5A1)	beta-Ionone	H’cvCH\ a
alpha-Ionone	Hi CH, 9 CH,
Citral	ch3 ch3 0
OR_7 (OR4E2)	Amyl acetate	0 A. ,CH->
Isoamyl acetate	o ch3 A — A h3c o ch3
Hexyl acetate	o h3Aah>3
OR_8 (OR2C1)	Nonanethiol	CH3(CH2)7CH2SH
Octanethiol	CH3(CH2)6CH2SH
Amyl mercaptan	CH3(CH2)3CH2SH
ORJO (OR8B8)	Acetophenone	o
Coumarin	CQO
Propiophenone	°Ych5 ό

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7-Methoxycoumarin

π,ο.θ,ΟζΧο

Four of the compounds for OR3 (highlighted in gray) were not tested individually on the receptors but were included in the mixes. All compounds were purchased from Sigma-Aldrich. In addition to individual compounds, mixes were tested in phase 2 of the project on some ORs. The composition of the mixes tested on some ORs in phase 2 are provided in Table 4.

Table 4.

Mix 1	Mix 2
Helional	Lilial
para-Anisaldehyde	m eta-Ani sal dehyde
4-Ethoxybenzaldehyde	4-Methyl-valeric acid
Menthol	Pentanol
Methyl-eugenol	Al 1 yl-phenyl acetate
Methyl-salicylate	Hexanoic acid
Phenylacetaldehyde	alpha-ionone
beta-ionone	Citral
Amyl acetate	Isoamylacetate
Nonan ethiol	Octanethiol
Acetophenone	Propiophenone
Coumarin	7-Methoxycoumari n

In phase 3, all positive combinations of ORs (always including human, dog, and 10 cat ORs) and odorants were tested in full dose-response curves. OR and odorant combinations tested in phase 3 are provided in Table 5.

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Table 5

OR	Odorant
OR_2	OR6P1	p-Anisaldehyde 4- Ethoxyb enzaldehyd e
		Isovaleric acid
OR_3	OR51E1	4-Methylvaleric acid Hexanoic acid 3-Metbyl-2-hexanoic acid
ORji	OR51L1	Hexanoic acid Allyl phenylacetate
OR_8	OR2C1	Nonanethiol
		Isovaleric acid
OR 9	OR5A1	Citral Amyl acetate β-Ionone
		Acetophenone
OR 10	OR8B8	Propriophenone
		Coumarin

Assay kits. The following kit were used according to the manufacterer’s instructions:

nano-Glo© Luciferase Assay System (Promega) for the CRE-NanoLuc luciferase assay. Assay protocols

CRE-NanoLuc luciferase assay. HEK293 PEAKrapid/RTP 1 s endo cells were transiently transfected with plasmids encoding the respective OR together with a CRENanoLuc luciferase plasmid (Promega) in a 1:1 ratio and were seeded at 20,000 cells/well in 25 pL/well complete growth medium in poly-D-lysine coated black, clearbottom 384 MTPs.

Twenty-four hours later, the cell medium was removed manually and cells were incubated with 20 pL/well Tyrode buffer. Compounds prepared in Tyrode buffer with 0 mM calcium were added to cells (10 pL/well of 3X solutions). Cells were then incubated at 37°C for 3-4 h. The plates were read in a luminescence plate reader (FLIPR^tetra,

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Molecular Devices), Luminescence (camera settings: exposure time: 0.99s; maximum gain) was recorded for 90s after addition of 20 pL/well of the NanoGlo reagent.

Data were analyzed with the Screenworks© software (Molecular Devices, version 4.0.0.30). Luminescence values (in RLU) were exported as averages from 20s75s. In addition to using raw values, the data were also normalized to background signals (wells containing buffer only) and expressed as “Fold change” (mean value (n=2) / mean value of buffer wells (n=2)). Data analysis and plotting of graphs was carried out using Excel (Microsoft) and GraphPad Prism (GraphPad Software, Inc.).

chAMPion (CNG channel) assay. HEK293/CNG/nat-Clytin/RTPls endo cells were transiently transfected with plasmids encoding the respective OR and were seeded at 20,000 cells/well in 25 pL/well complete growth medium in poly-D-lysine coated black, clear-bottom 384 MTPs.

Twenty-four hours later, the cell medium was removed manually and cells were incubated in 20 pL/well coel enter azine (11 μΜ) in Tyrode buffer with 0 mM calcium for 3.5h at 37°C. Plates were then read in a luminescence plate reader (FLIPR^tetra, Molecular Devices) with the following camera settings: exposure time: 0.533s, maximum gain. Luminescence was recorded for 1 min after addition of 10 pL/well compounds (3x solutions prepared in Tyrode buffer with 0 mM calcium), followed by an incubation period of 30 min at 37°C. Luminescence was again recorded for 1 min after addition of 20 pL/well Tyrode buffer with 10 mM CaCL. The first reading after compound addition monitors the receptor-Ga_q signaling pathway - as expected, no signals were observed here. The second reading after addition of calcium monitors ORGa_s signaling; these data were analyzed.

Data were analyzed with the Screenworks© software (Molecular Devices, version 4.0.0.30). Luminescence values (in RLU) were exported as maximum RLU between 10s and 40s. In addition to using raw values, the data were also normalized to background signals (wells containing buffer only) and expressed as “Fold change” (mean value (n~2) / mean value of buffer wells (n-2)). Data analysis and plotting of graphs was carried out using Excel (Microsoft) and GraphPad Prism (GraphPad Software, Inc.).

Results in phase 1 of the project, twenty OR sequences, ten canine and ten feline sequences, to be analyzed in this project, were submitted by Mars Petcare. The OR sequences were synthesized and subcloned into an expression vector adding a transport

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PCT/US2017/054620 epitope tag to the N-terminus of the OR proteins to facilitate their expression and plasma membrane localization.

A first functional test of the canine and feline ORs was carried out in phase 2.

Sets of ORs, each consisting of human, cat, and dog orthologs (and in case of OR_10. OR8B8, also the mouse ortholog), were tested with three concentrations of a minimum of three odorants, pre-selected on the basis of published activity on the human ortholog or predicted potential activity. Most sets of ORs were also challenged with two mixes consisting of 12 odorants each. All sets of ORs were tested in parallel in two cell-based assays, CRE-NanoLuc luciferase assay and CNG chAMPion assay. These two assays were found to be the two best assays for the ten human ORs, which were tested in a previous study.

Of the ten sets of ORs that were tested in phase 2, seven sets showed responses of at least one receptor ortholog to at least one compound (Figures 14 and 15). Several ORs responded to more than one compound. For four sets of ORs, both dog and cat ORs showed activity; these include the set of OR 2 (OR6P1) for which the human ortholog did not respond to the same set of ligands as did the dog and cat receptors. For three other sets of ORs only the dog ortholog or the cat ortholog, respectively, responded.

In phase 3 of the project, six positive OR sets, including all available orthologs, were re-tested with their positive ligands in eight concentrations and dose-response curves were calculated. The results of phase 3 are summarized Figures 16 and 17,

Briefly, six dog ORs were shown to be active (with numbers of ligands): OR6P1 (2); OR51E1 (3-4); OR51L1 (1); OR2C1 (1); OR5A1 (4); OR8B8 (3). In addition, six cat ORs showed activity: OR6P1 (2); OR51E1 (3-4); OR5IL1 (2); OR4E2 (1); OR2C1 (1); OR5A1 (4); OR8B8 (1).

All data are presented in full detail in Figures 18-43. Figures 18-37 represent the results obtained in phase 2 assays. Figures 38-43 represent the dose-response curves of the positive ligands in phase 3 assays. The following data were exported: CRELuciferase: Average 15s-60s; chAMPion assay: Maximum 10s-30s. Data were normalized as “Fold Change” (compared to mean of buffer values). The base of all logarithm is 10.

Example 4 - Identification of canine and feline olfactory receptor modulators using in vitro assays.

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The present example describes an in vitro assay for identifying compounds that modulate the activation of a canine or feline olfactory receptor by an olfactory receptor ligand.

Compounds identified by in silico modeling with an olfactory receptor, as detailed above in Example 1, as putative olfactory receptor modulators are selected for further testing in vitro. In vitro functional characterization of the selected modulators is used to evaluate the effectiveness of a putative modulator compound in modulating the activation of the olfactory receptor by an olfactory receptor ligand.

HEK293 cells (or other suitable expression system) that stably or transiently express a canine or feline olfactory receptor (e.g., canine CafaOR9.2.9, CafaOR38.1.21, CafaOR21.2.15, CafaOR21.2.43, CafaORl5.2.20, CafaOR18.3.11, CafaOR15.3.1, CafaOR6.3.1, CafaOR 18.3.12, CafaOR5.2.5, or feline El :13347030-13347977 ,

FI :65134904-65135858 , DI :62955839-62956792 , DI :63312327-63313289 ,

B3:72908295-72909287 , DI :105486528-105487493 , B3:74116955-74117893 ,

E3:40237904-40238842,01:105462554-105463512 , DI :21266824-21267768, or any one of the receptors having a nucleotide seqeunce or an amino acid sequence set forth in SEQ ID NOs:61-3808) are exposed to putative modulator compounds and an olfactory receptor ligand (e.g., an agonist) to modulate the activity and/or expression of the olfactory receptor.

An exemplary method of an in vitro assay is as follows. All transient transfections are performed with, for example, Lipofectamine2000 (invitrogen) according to the manufactures protocol. 10 μΐ Lipofectamine2000 is diluted in 500 μΐ DMEM (Life Technologies) and incubated for 5 minutes at room temperature. 3 pg of plasmid DNA (1 pg/μΐ) is diluted in 500 μΐ DMEM and added to the Lipofectamine2000 mix to obtain a final volume of 1000 μΐ. After additional 30 minutes of incubation at room temperature, the DNA-Lipofectamine complex is added to 1000 μΐ of a cell suspension containing 1,400,000 cells/ml. Subsequently, 25 μΐ of the complete mixture is seeded into each well of a black 384 well polystyrene assay plate. At 3 hours posttransfection the transfection mix is removed from the cells and fresh DMEM containing 10% FBS and 1% P/S is added. At 27 to 30 hours post-transfection the medium is removed from the cells and 20 μΐ loading buffer that includes a calcium sensitive fluorescent dye or luminescent substrate (Tyrode’s buffer + 2 μΜ Fluo4-AM (Invitrogen) + 2.5 mM probenecid (Invitrogen) for fluorescence or Coelenterazine

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PCT/US2017/054620 (Biosynth) + Tyrode’s buffer for luminescence) is added for 1 hour (fluorescence) or 3 hours (luminescence) at 37°C. The cells are then washed 2 times every 20 minutes with Tyrode’s buffer using an automated plate washer (Biochrom Asys Plate Washer) for the fluorescent protocol. No wash step is required for the luminescent protocol.

Activation of the olfactory receptor is then detected, for example, by detecting a change in intracellular calcium levels using the calcium sensitive fluorescent dye, the calcium sensitive luminescent photoprotein, or by any detection system known in the art. Cells that do not express the olfactory receptor (MOCK control) are used as a control. Examples of such data capturing systems include FLIPR® Tetra or a FlexStation® 3 system. However, other imaging techniques and systems can be used, for example, microscopic imaging of the treated cells.

For each putative olfactory receptor modulator, dose response curves are generated with at least 8 concentrations in triplicate and the EC50 value of the putative olfactory receptor modulator is determined. Graphs are plotted, for example, in SigmaPlot VI2 (Systat Software) with error bars representing standard error.

References

Niimura, Y., & Nei, M. (2007). Extensive Gains and Losses of Olfactory Receptor Genes in Mammalian Evolution. PLoS ONE, 2(8), e708. http://d0i.0rg/l 0.1371 /joumal.pone.0000708

Niimura, Y., Matsui, A., & Touhara, K, (2015). Corrigendum: Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals. Genome Research, 25(6), 926.

Fu L, Niu B, Zhu Z, Wu S, Li W. CD-HIT: accelerated for clustering the nextgeneration sequencing data. Bioinformatics. 2012 Dec 1;28(23):3150-2. doi:10.1093/bioinformatics/bts565. Epub 2012 Oct 11. PubMed PMID: 23060610; PubMedCentral PMCID: PMC3516142.

Rice P, Longden I, Bleasby A. EMBOSS: the European Molecular Biology Open Software Suite. Trends Genet. 2000 Jun; 16(6):276-7. PubMed PMID: 10827456.

Although the presently disclosed subject matter and its advantages have been

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PCT/US2017/054620 described in detail, it should be understood that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims. Moreover, the scope of the present application is not intended to be limited to the particular embodiments of the process, machine, manufacture, composition of matter, means, methods and steps described in the specification. As one of ordinary skill in the art will readily appreciate from the disclosure of the presently disclosed subject matter, processes, machines, manufacture, compositions of matter, means, methods, or steps, presently existing or later to be developed that perform substantially the same function or achieve substantially the same result as the corresponding embodiments described herein may be utilized according to the presently disclosed subject matter. Accordingly, the appended claims are intended to include within their scope such processes, machines, manufacture, compositions of matter, means, methods, or steps.

Patents, patent applications, publications, product descriptions and protocols are cited throughout this application the disclosures of which are incorporated herein by reference in their entireties for all purposes.

Claims (40)

1. A composition capable of modulating an activity of an olfactory receptor identified according a method comprising:

(a) measuring a first activity of the olfactory receptor, (b) contacting a test agent with the olfactory receptor, (c) measuring a second activity of the olfactory receptor after contacting the test agent, and (d) determining that the test agent is a compound capable of modulating the activity of the olfactory receptor when the second activity of the olfactory receptor is increased or decreased compared to the first activity of the olfactory receptor.

2. The composition of claim 1, wherein the olfactory receptor is a canine or feline olfactory receptor comprising an amino acid sequence selected from the group consisting of amino acid sequences set forth in SEQ ID NOs: 61-3,808.

3. The composition of claim 1, wherein the olfactory receptor is a canine or feline olfactory receptor comprising an amino acid sequence selected from the group consisting of SEQ lDNOs:41-60.

4. A composition capable of modulating an activity of an olfactory receptor identified according a method comprising (a) contacting a test agent with an olfactory receptor, (b) detecting an interaction between the test agent and one or more amino acids of the olfactory receptor, and (c) determining that the test agent is a compound capable of modulating the activity of the olfactory receptor when the test agent interacts with one or more of the amino acids.

5. The composition of claim 4, wherein the method comprises detecting an interaction between the test agent and one or more amino acids in a 7 transmembrane domain (7TM) domain of the olfactory receptor.

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6. The composition of claim 4 or 5, wherein the method further comprising measuring a first activity of the olfactory receptor before contacting the test agent, and measuring a second activity of the olfactory receptor after contacting the test agent,

7. The composition of any one of claims 4-6, wherein the method further comprising contacting an olfactory receptor ligand to the olfactory receptor.

8. The composition of any one of claims 4-7, wherein the method further comprising determining that the test agent is a compound capable of decreasing the activity of the olfactory receptor when the second activity of the olfactory receptor is decreased compared to the first activity of the olfactory receptor.

9. The composition of any one of claims 4-7, wherein the method further comprising determining that the test agent is a compound capable of increasing the activity of the olfactory receptor when the second activity of the olfactory receptor is increased compared to the first activity of the olfactory receptor.

10. The composition of any one of claims 4-9, wherein the olfactory receptor is a canine or feline olfactory receptor comprising an amino acid sequence selected from the group consisting of amino acid sequences set forth in SEQ ID NOs: 61-3,808.

11. The composition of any one of claims 4-9, wherein the olfactory receptor is a canine or feline olfactory receptor comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:41-60.

12. The composition of any one of claims 4-11, wherein the olfactory receptor is a canine CafaOR9.2.9 olfactory receptor comprising an amino acid sequence described by SEQ ID NO:41, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Glnl03, Leu 104, Lys275, Arg87, Val81, Met84, Val279, Tyr262, Met209, Gly258, Vail 11, Tyr255, Thr282, Phel07 and Thr80.

13. The composition of any one of claims 4-11, wherein the olfactory receptor is a canine CafaOR38.1.21 olfactory receptor comprising an amino acid sequence described by SEQ ID NO:42, and wherein the one or more amino acids of the olfactory receptor

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PCT/US2017/054620 are selected from the group consisting of Lys273, Thr78, Leu82, Tyr260, Thr256, Tyr253 and Phel05.

14. The composition of any one of claims 4-11, wherein the olfactory receptor is a canine CafaOR21.2.15 olfactory receptor comprising an amino acid sequence described by SEQ ID NO:43, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Metl 03, Met83, Hisl07, Ilel06, Leul82, Asnl97, Gly201, Val204, Ser260, Phe256 and Leu273.

15. The composition of any one of claims 4-11, wherein the olfactory receptor is a canine CafaOR21.2.43 olfactory receptor comprising an amino acid sequence described by SEQ ID NO:44, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Asp285, Met80, Met88, Leul08, lie 111,

Hisl 12, Thrl 15, VaI209, Val210, Thr213, Leu214, Val262, Ile263, Ser266, Ile281, Ala284,and Leu288.

16. The composition of any one of claims 4-11, wherein the olfactory receptor is a feline catGr5 (B3:72908295-72909287) olfactory receptor comprising an amino acid sequence described by SEQ ID NO: 55, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Tyr277, Lys290, Phel 19, Prol77, Leul80, llel81, Prol99, Cys217, and Phe220.

17. The composition of any one of claims 4-11, wherein the olfactory receptor is a feline catGr6 (DI :105486528-105487493) olfactory receptor comprising an amino acid sequence described by SEQ ID NO: 56, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Hisl 12, Asn209, Tyr265, Phe88, Phel 11, Metl 70, Met206, Cys261, Ile264, Ser279, Ile280, and Thr283.

18. The composition of any one of claims 4-11, wherein the olfactory receptor is a feline catG7 (B3:74116955-74117893) olfactory receptor comprising an amino acid sequence described by SEQ ID NO:57, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Met81, Tyr258, GlnlOO, Thr77, Lys269, Leu304, Thr276, Val277, His73, Val273 and Val78.

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19. The composition of any one of claims 4-11, wherein the olfactory receptor is a feline catG8 (E3:40237904-40238842) olfactory receptor comprising an amino acid sequence described by SEQ ID NO:58, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Met83, LeulOl, Phel 04, Leul05, Gly 108, Glul 80, Val202, Phe206, Tyr259, and Lys272.

20. The composition of any one of claims 4-11, wherein the olfactory receptor is a feline catG9 (DI :105462554-105463512) olfactory receptor comprising an amino acid sequence described by SEQ ID NO:59, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Tyr79, Lys278, Phel 10,

Vail 11, Glyl 34, Val208, lle212, Phe258, Ala261, Leu262, Tyr265, Val282, and Ser285.

21. The composition of any one of claims 4-11, wherein the olfactory receptor is a canine CafaOR.5.2.5 olfactory receptor comprising an amino acid sequence described by SEQ ID NO:50, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Tyr263, Tyr77, Phel 08, Vail 12, Seri 16, Val206, Asp210, Phe256, and Thr283.

22. The composition of any one of claims 4-21, wherein the interaction is determined by site directed mutagenesis, x-ray crystallography, x-ray spectroscopy, Nuclear Magnetic Resonance (NMR), cross-linking assessment, mass spectroscopy, electrophoresis, displacement assay, and combinations thereof.

23. A composition capable of modulating an activity of an olfactory receptor identified according a method comprising (a) contacting an olfactory receptor agonist with an olfactory receptor, (b) measure a first activity of the olfactory receptor, (c) contacting a test agent with the olfactory receptor, (d) measure a second activity of the olfactory receptor, and (e) determining that the test agent is a compound capable of modulating the activity of the olfactory receptor when the first activity is greater or lesser than the second activity.

24. The composition of claim 23, wherein the olfactory receptor is a canine or feline

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PCT/US2017/054620 olfactory receptor comprising an amino acid sequence selected from the group consisting of amino acid sequences set forth in SEQ ID NOs: 61-3,808.

25. The composition of claim 23, wherein the olfactory receptor is a canine or feline 5 olfactory receptor comprising an amino acid sequence selected from the group consisting of SEQ IDNO:41-60.

26. The composition of claim 23, wherein the olfactory receptor agonist is selected from the group consisting of trifemal, isovaleric acid, 3-methyl-2-hexanoic acid, alpha10 ionone, hexyl acetate, amyl mercaptan, helional, para-anisaldehyde, 4ethoxybenzaldehyde, menthol, methyl-eugenol, methyl-salicyl ate, phenylacetaldehyde, beta-ionone, amyl acetate, nonanethiol, acetophenone, coumarin, lilial, metaanisaldehyde, 4-methyl-valeric acid, pentanol, allyl-phenylacetate, hexanoic acid, alphaionone, citral, isoamylacetate, octanethiol, propiophenone, 7-methoxycoumarin and

15 combinations thereof.

27. The composition of any one of claims 1-3 and 23-26, wherein the test agent has an EC₅o value of no more than about 200 μΜ,

20 28. The composition of any one of claims 1-3 and 23-26, wherein the test agent has an Emax value of no less than about 2.0.

29. The composition of any one of claims 1-3, wherein step (c) comprises determining that the test agent is a compound capable of modulating the activity of the

25 olfactory receptor when the activity of the olfactory receptor is decreased after contacting the test agent.

30. The composition of any one of claims 1-3, wherein step (c) comprises determining that the test agent is a compound capable of modulating the activity of the

30 olfactory receptor when the activity of the olfactory receptor is increased after contacting the test agent

31. A food product comprising the composition of any one of claims 1 -30.

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32. The food product of claim 31, wherein the composition is present at a concentration of from about 0.0001 weight % to about 10 weight % of the food product.

33. The food product of claim 31, wherein the composition is present at a concentration of from about 0.001 ppm to about 1,000 ppm of the food product.

34. The food product of claim 31, wherein the composition is present at a concentration of from about 1 μΜ to about 1 M of the food product.

35. The food product of any one of claims 31-34, wherein the composition is present in an amount effective to increase the palatability of the food product, as determined by a panel of taste testers.

36. The food product of any one of claims 31-3, wherein the food product comprises a pet food product.

37. The food product of any one of claims 31-3, wherein the pet food product is a feline pet food product or a canine pet food product.

38. The food product of any one of claims 31-3, wherein the feline pet food product is a wet pet food product or a dry pet food product.

39. A method of increasing an odor intensity in a food product comprising admixing a food product with the composition of any one of claims 1-30, wherein the composition is present at a concentration of from about 0.0001 weight % to about 10 weight % of the admixture.

40. A method of increasing an odor intensity in a food product comprising admixing a food product with the composition of any one of claims 1-30, wherein the composition is present at a concentration of from about 0.001 ppm to about 1,000 ppm of the admixture.

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41. A method of increasing an odor intensity in a food product comprising admixing a food product with the composition of any one of claims 1-30, wherein the composition is present at a concentration of from about 1 μΜ to about 1 M of the admixture.

42. A method of preparing a food product comprising a composition according to any one of claims 1-30, wherein the method comprises thermal processing of a food product precursor, wherein the composition is generated during the thennal processing.

43. The method of claim 42, wherein the thennal processing comprises sterilization, retorting, extrusion, injection molding or combinations thereof.

44. A method for identifying a compound capable of modulating activity of an olfactory receptor comprising:

(a) measuring a first activity of the olfactory receptor, (b) contacting a test agent with the olfactory receptor, (c) measuring a second activity of the olfactory receptor after contacting the test agent, and (d) determining that the test agent is a compound capable of modulating the activity of the olfactory receptor when the second activity of the olfactory receptor is increased or decreased compared to the first activity of the olfactory receptor.

45. The method of claim 44, wherein the olfactory receptor is a canine or feline olfactory receptor comprising an amino acid sequence selected from the group consisting of amino acid sequences set forth in SEQ ID NOs: 61-3,808.

46. The method of claim 44, wherein the olfactory receptor is a canine or feline olfactory receptor comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:41-60.

47. A method for identifying a compound capable of modulating the activity of an olfactory receptor comprising (a) contacting a test agent with an olfactory receptor, (b) detecting an interaction between the test agent and one or more amino

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PCT/US2017/054620 acids of the olfactory receptor, and (c) determining that the test agent is a compound capable of modulating the activity of the olfactory receptor when the test agent interacts with one or more of the amino acids.

48. The method of claim 47, wherein the method comprises detecting an interaction between the test agent and one or more amino acids in a 7 transmembrane domain (7TM) domain of the olfactory receptor,

49. The method of claim 47 or 48, further comprising measuring a first activity of the olfactory receptor before contacting the test agent, and measuring a second activity of the olfactory receptor after contacting the test agent.

50. The method of any one of claims 47-49, further comprising contacting an olfactory receptor ligand to the olfactory receptor.

51. The method of any one of claims 47-50, further comprising determining that the test agent is a compound capable of decreasing the activity of the olfactory receptor when the second activity of the olfactory receptor is decreased compared to the first activity of the olfactory receptor.

52. The method of any one of claims 47-50, further comprising determining that the test agent is a compound capable of increasing the activity of the olfactory receptor when the second activity of the olfactory receptor is increased compared to the first activity of the olfactory receptor.

53. The method of any one of claims 47-52, wherein the olfactory receptor is a canine or feline olfactory receptor comprising an amino acid sequence selected from the group consisting of amino acid sequences set forth in SEQ ID NOs: 61-3,808.

54. The method of any one of claims 47-52, wherein the olfactory receptor is a canine or feline olfactory receptor comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:41-60.

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55. The method of any one of claims 47-54, wherein the olfactory receptor is a canine CafaOR9.2.9 olfactory receptor comprising an amino acid sequence described by SEQ ID NO:41, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Gln 103, Leu 104, Lys275, Arg87, Val81, Met84, Val279, Tyr262, Met209, Gly258, Vail 11, Tyr255, Thr282, Phel07 and Thr80.

56. The method of any one of claims 47-54, wherein the olfactory receptor is a canine CafaOR38.1.21 olfactory receptor comprising an amino acid sequence described by SEQ ID NO:42, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Lys273, Thr78, Leu82, Tyr260, Thr256,

Tyr253 and Phel 05.

57. The method of any one of claims 47-54, wherein the olfactory receptor is a canine CafaOR21.2.15 olfactory receptor comprising an amino acid sequence described by SEQ ID NO:43, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Metl03, Met83, Hisl07, Ilel06, Leul82, Asnl97, Gly201, Val204, Ser260, Phe256 and Leu273.

58. The method of any one of claims 47-54, wherein the olfactory receptor is a canine CafaOR21.2.43 olfactory receptor comprising an amino acid sequence described by SEQ ID NO:44, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Asp285, Met80, Met88, Leul08, Ilel 11,

His 112, Thr 115, Val209, Val210, Thr213, Leu214, Val262, Ile263, Ser266, Ile281, Ala284, and Leu288.

59. The method of any one of claims 47-54, wherein the olfactory receptor is a feline catGr5 (B3:72908295-72909287) olfactory receptor comprising an amino acid sequence described by SEQ ID NO:55, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Tyr277, Lys290, Phel 19, Prol 77,

Leu 180, Ilel 81, Pro 199, Cys217, and Phe220.

60. The method of any one of claims 47-54, wherein the olfactory receptor is a feline catGr6 (DI: 105486528-105487493) olfactory receptor comprising an amino acid sequence described by SEQ ID NO :56, and wherein the one or more amino acids of the

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61. The method of any one of claims 47-54, wherein the olfactory receptor is a feline catG7 (B3:74116955-74117893) olfactory receptor comprising an amino acid sequence described by SEQ ID NO:57, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Met81, Tyr258, GlnlOO, Thr77, Lys269, Leul04, Thr276, Val277, His73, Val273 and Val78.

62. The method of any one of claims 47-54, wherein the olfactory receptor is a feline catG8 (E3:40237904-40238842) olfactory receptor comprising an amino acid sequence described by SEQ ID NO:58, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Met81, LeulOl, Phel04, LeulOS, Glyl08, Glul80, Val202, Phe206, Tyr259, and Lys272.

63. The method of any one of claims 47-54, wherein the olfactory receptor is a feline catG9 (Dl:105462554-105463512) olfactory receptor comprising an amino acid sequence described by SEQ ID NO:59, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Tyr79, Lys278, Phel 10,

Vail 11, Glyll4, Val2O8, lle212, Phe258, Ala261, Leu262, Tyr265, Val282, and Ser285.

64. The method of any one of claims 47-54, wherein the olfactory receptor is a canine CafaOR5.2.5 olfactory receptor comprising an amino acid sequence described by SEQ ID NO:50, and wherein the one or more amino acids of the olfactory receptor are selected from the group consisting of Tyr263, Tyr77, PhelOS, Vail 12, Seri 16, Val206, Asp210, Phe256, and Thr283.

65. The method of any one of claims 47-64, wherein the interaction is determined by site directed mutagenesis, x-ray crystallography, x-ray spectroscopy, Nuclear Magnetic Resonance (NMR), cross-linking assessment, mass spectroscopy, electrophoresis, displacement assay, and combinations thereof.

66. A method for identifying a compound capable of modulating activity of an olfactory receptor comprising

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PCT/US2017/054620 (a) contacting an olfactory receptor agonist with an olfactory receptor, (b) measure a first activity of the olfactory receptor, (c) contacting a test agent with the olfactory receptor, (d) measure a second activity of the olfactory receptor, and (e) determining that the test agent is a compound capable of modulating the activity of the olfactory receptor when the first activity is greater or lesser than the second activity.

67. A method for selecting a pet food product or component thereof, comprising (a) measuring a first activity of the olfactory receptor, (b) contacting a test agent with the olfactory receptor, (c) measuring a second activity of the olfactory receptor after contacting the test agent, and (d) selecting the test agent as a pet food product, or component thereof, when the second activity of the olfactory receptor is increased or decreased compared to the first activity of the olfactory receptor.

68. The method of claim 66 or 67, wherein the olfactory receptor is a canine or feline olfactory receptor comprising an amino acid sequence selected from the group consisting of amino acid sequences set forth in SEQ ID NOs: 61-3,808.

69. The method of claim 66 or 67, wherein the olfactory receptor is a canine or feline olfactory receptor comprising an amino acid sequence selected from the group consisting of SEQ ID NO:41-60.

70. The method of claim 66, wherein the olfactory receptor agonist is selected from the group consisting of trifemal, isovaleric acid, 3-methyl-2-hexanoic acid, alpha-ionone, hexyl acetate, amyl mercaptan, helional, para-anisaldehyde, 4-ethoxybenzaldehyde, menthol, methyl-eugenol, methyl-salicylate, phenylacetaldehyde, beta-ionone, amyl acetate, nonanethiol, acetophenone, coumarin, lilial, meta-anisaldehyde, 4-methyl-valeric acid, pentanol, allyl-phenylacetate, hexanoic acid, alpha-ionone, citral, isoamyl acetate, octanethiol, propiophenone, 7-methoxycoumarin and combinations thereof.

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71. The composition of any one of claims 44-47 and 66-69, wherein the test agent has an EC₅o value of no more than about 200 μΜ.

72. The composition of any one of claims 44-47 and 66-69, wherein the test agent 5 has an Emax value of no less than about 2.0.

73. The composition of any one of claims 44-47, wherein step (c) comprises detennining that the test agent is a compound capable of modulating the activity of the olfactory receptor when the activity of the olfactory receptor is decreased after

10 contacting the test agent.

74. The composition of any one of claims 44-47, wherein step (c) comprises determining that the test agent is a compound capable of modulating the activity of the olfactory receptor when the activity of the olfactory receptor is increased after contacting

15 the test agent

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Olfactory Receptor Nucleotide Sequences and Corresponding Amino Acid Sequences

HsOR17.1.11 (hOR3A1) nucleotide sequence (SEQ ID N0:1)

ATGCAGCCAGAATCTGGGGCCAATGGAACAGTCATTGCTGAGTTCATCCTGCTGGGCTTGCTGGAGGC

GCCAGGGCTGCAGCCAGTTGTCTTTGTGCTCTTCCTCTTTGCCTACCTGGTCACGGTCAGGGGCAACC

TCAGCATCCTGGCAGCTGTCTTGGTGGAGCCCAAACTCCACACCCCCATGTACTTCTTCCTGGGGAAC

CTATCAGTGCTGGATGTTGGGTGCATCAGCGTCACTGTTCCATCAATGTTGAGTCGTCTCCTGTCCCG

CAAGCGTGCAGTTCCCTGTGGGGCCTGCCTTACCCAGCTCTTCTTCTTCCATCTGTTCGTTGGAGTGG

ACTGCTTCCTGCTGACCGCCATGGCCTATGACCGATTCCTGGCCATCTGCCGGCCCCTCACCTACAGC

ACCCGCATGAGTCAGACAGTCCAGAGGATGTTGGTGGCTGCGTCCTGGGCTTGTGCTTTCACCAACGC

ACTGACCCACACTGTGGCCATGTCCACGCTCAACTTCTGTGGCCCCAATGTGATCAATCACTTCTACT

GTGACCTCCCACAGCTCTTCCAGCTCTCCTGCTCCAGCACCCAACTCAATGAGCTGCTGCTTTTTGCT

GTGGGTTTTATAATGGCAGGTACCCCCATGGCTCTCATTGTCATCTCCTATATCCACGTGGCAGCTGC

AGTCCTGCGAATTCGCTCTGTAGAGGGCAGGAAGAAAGCCTTCTCCACATGTGGCTCCCACCTCACTG

TGGTTGCCATATTCTATGGTTCAGGTATCTTTAACTATATGCGACTGGGTTCAACCAAGCTTTCAGAC

AAGGATAAAGCTGTTGGAATTTTCAACACTGTCATCAATCCCATGCTGAACCCAATCATCTACAGCTT

CAGAAACCCTGATGTGCAGAGTGCCATCTGGAGGATGCTCACAGGGAGGCGGTCACTGGCTTGA

HsOR17.1.11 (hOR3A1) amino acid sequence (SEQ ID N0:31)

MQPESGANGTVIAEFILLGLLEAPGLQPVVFVLFLFAYLVTVRGNLSILAAVLVEPKLHTPMYFFLGN LSVLDVGCISVTVPSMLSRLLSRKRAVPCGACLTQLFFFHLFVGVDCFLLTAMAYDRFLAICRPLTYS TRMSQTVQRMLVAASWACAFTNALTHTVAMSTLNFCGPNVINHFYCDLPQLFQLSCSSTQLNELLLFA VGFIMAGTPMALIVISYIΗVAAAVLRIRSVEGRKKAFSTCGSHLTVVAIFYGSGIFNYMRLGSTKLSD KDKAVGIFNTVINPMLNP11YSFRNPDVQSAIWRMLTGRRSLA

FIG. 1

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HsOR1.4.8 (hOR6P1) nucleotide sequence (SEQ ID N0:2)

ATGAGAAATTTGAGTGGAGGCCATGTCGAGGAGTTTGTCTTGGTGGGTTTCCCTACCACGCCTCCCCT

CCAGCTGCTCCTCTTTGTCCTTTTTTTTGCAATTTACCTTCTGACATTGTTGGAGAATGCACTTATTG

TCTTCACAATATGGCTTGCTCCAAGCCTTCATCGTCCCATGTACTTTTTCCTTGGCCATCTCTCTTTC

CTGGAGCTATGGTACATCAATGTCACCATTCCTCGGCTCTTGGCAGCCTTTCTTACCCAGGATGGTAG

AGTCTCCTACGTAGGTTGCATGACCCAACTGTACTTCTTTATTGCCTTAGCCTGTACTGAATGTGTGC

TGTTGGCAGTTATGGCCTATGATCGCTACCTGGCCATCTGTGGACCCCTCCTTTACCCTAGTCTCATG

CCTTCCAGTCTGGCCACTCGCCTTGCTGCTGCCTCTTGGGGCAGTGGCTTCTTCAGCTCCATGATGAA

GCTTCTTTTTATTTCCCAATTGTCCTACTGTGGACCCAACATTATCAACCACTTTTTCTGTGATATTT

CCCCACTACTCAACCTCACCTGCTCTGACAAGGAGCAAGCAGAGCTAGTAGACTTCCTTCTGGCCCTG

GTGATGATTCTACTCCCTCTATTGGCTGTGGTTTCATCATACACTGCCATCATTGCAGCCATCCTGAG

GATCCCTACGTCCAGGGGACGCCACAAAGCCTTTTCCACTTGTGCCGCTCATCTGGCAGTGGTTGTTA

TCTACTACTCCTCCACTCTCTTCACCTATGCACGGCCCCGGGCCATGTACACCTTCAACCACAACAAG

ATTATCTCTGTGCTCTACACTATCATTGTACCATTCTTCAACCCAGCCATCTACTGCCTGAGGAACAA

GGAGGTGAAGGAGGCCTTCAGGAAGACAGTGATGGGCAGATGTCACTATCCTAGGGATGTTCAGGACT

GA

HsOR1.4.8 (hOR6P1) amino acid sequence (SEQ ID N0:32)

MRNLSGGHVEEFVLVGFPTTPPLQLLLFVLFFAIYLLTLLENALIVFTIWLAPSLHRPMYFFLGHLSF LELWYINVTIPRLLAAFLTQDGRVSYVGCMTQLYFFIALACTECVLLAVMAYDRYLAICGPLLYPSLM PSSLATRLAAASWGSGFFSSMMKLLFISQLSYCGPN11NHFFCDISPLLNLTCSDKEQAELVDFLLAL VMILLPLLAVVSSYTA11AAILRIPTSRGRHKAFSTCAAHLAVVVIYYSSTLFTYARPRAMYTFNHNK IISVLYTIIVPFFNPAIYCLRNKEVKEAFRKTVMGRCHYPRDVQD*

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HsORl 1.3.14 (K0R51E1) nucleotide sequence (SEQ ID N0:3)

ATGATGGTGGATCCCAATGGCAATGAATCCAGTGCTACATACTTCATCCTAATAGGCCTCCCTGGTTT

AGAAGAGGCTCAGTTCTGGTTGGCCTTCCCATTGTGCTCCCTCTACCTTATTGCTGTGCTAGGTAACT

TGACAATCATCTACATTGTGCGGACTGAGCACAGCCTGCATGAGCCCATGTATATATTTCTTTGCATG

CTTTCAGGCATTGACATCCTCATCTCCACCTCATCCATGCCCAAAATGCTGGCCATCTTCTGGTTCAA

TTCCACTACCATCCAGTTTGATGCTTGTCTGCTACAGATGTTTGCCATCCACTCCTTATCTGGCATGG

AATCCACAGTGCTGCTGGCCATGGCTTTTGACCGCTATGTGGCCATCTGTCACCCACTGCGCCATGCC

ACAGTACTTACGTTGCCTCGTGTCACCAAAATTGGTGTGGCTGCTGTGGTGCGGGGGGCTGCACTGAT

GGCACCCCTTCCTGTCTTCATCAAGCAGCTGCCCTTCTGCCGCTCCAATATCCTTTCCCATTCCTACT

GCCTACACCAAGATGTCATGAAGCTGGCCTGTGATGATATCCGGGTCAATGTCGTCTATGGCCTTATC

GTCATCATCTCCGCCATTGGCCTGGACTCACTTCTCATCTCCTTCTCATATCTGCTTATTCTTAAGAC

TGTGTTGGGCTTGACACGTGAAGCCCAGGCCAAGGCATTTGGCACTTGCGTCTCTCATGTGTGTGCTG

TGTTCATATTCTATGTACCTTTCATTGGATTGTCCATGGTGCATCGCTTTAGCAAGCGGCGTGACTCT

CCGCTGCCCGTCATCTTGGCCAATATCTATCTGCTGGTTCCTCCTGTGCTCAACCCAATTGTCTATGG

AGTGAAGACAAAGGAGATTCGACAGCGCATCCTTCGACTTTTCCATGTGGCCACACACGCTTCAGAGC

CCTA

HsORl 1.3.14 (K0R51E1) amino acid sequence (SEQ ID N0:33)

MMVDPNGNESSATYFILIGLPGLEEAQFWLAFPLCSLYLIAVLGNLT11YIVRTEHSLHEPMYIFLCM LSGIDILISTSSMPKMLAIFWFNSTTIQFDACLLQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHA TVLTLPRVTKIGVAAVVRGAALMAPLPVFIKQLPFCRSNILSHSYCLHQDVMKLACDDIRVNVVYGLI V11SAIGLDSLLISFSYLLILKTVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFSKRRDS PLPVILANIYLLVPPVLNPIVYGVKTKEIRQRILRLFHVATHASEP*

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HsORl 1.3.40 (K0R51L1) nucleotide sequence (SEQ ID N0:4)

ATGGGAGACTGGAATAACAGTGATGCTGTGGAGCCCATATTTATCCTGAGGGGTTTTCCTGGACTGGA

GTATGTTCATTCTTGGCTCTCCATCCTCTTCTGTCTTGCATATTTGGTAGCATTTATGGGTAATGTTA

CCATCCTGTCTGTCATTTGGATAGAATCCTCTCTCCATCAGCCCATGTATTACTTTATTTCCATCTTA

GCAGTGAATGACCTGGGGATGTCCCTGTCTACACTTCCCACCATGCTTGCTGTGTTATGGTTGGATGC

TCCAGAGATCCAGGCAAGTGCTTGCTATGCTCAGCTGTTCTTCATCCACACATTCACATTCCTGGAGT

CCTCAGTGTTGCTGGCCATGGCCTTTGACCGTTTTGTTGCTATCTGCCATCCACTGCACTACCCCACC

ATCCTCACCAACAGTGTAATTGGCAAAATTGGTTTGGCCTGTTTGCTACGAAGCTTGGGAGTTGTACT

TCCCACACCTTTGCTACTGAGACACTATCACTACTGCCATGGCAATGCCCTCTCTCACGCCTTCTGTT

TGCACCAGGATGTTCTAAGATTATCCTGTACAGATGCCAGGACCAACAGTATTTATGGGCTTTGTGTA

GTCATTGCCACACTAGGTGTGGATTCAATCTTCATACTTCTTTCTTATGTTCTGATTCTTAATACTGT

GCTGGATATTGCATCTCGTGAAGAGCAGCTAAAGGCACTCAACACATGTGTATCCCATATCTGTGTGG

TGCTTATCTTCTTTGTGCCAGTTATTGGGGTGTCAATGGTCCATCGCTTTGGGAAGCATCTGTCTCCC

ATAGTCCACATCCTCATGGCAGACATCTACCTTCTTCTTCCCCCAGTCCTTAACCCTATTGTCTATAG

TGTCAGAACAAAGCAGATTCGTCTAGGAATTCTCCACAAGTTTGTCCTAAGGAGGAGGTTTTAA

HsORl 1.3.40 (K0R51L1) amino acid sequence (SEQ ID N0:34)

MGDWNNSDAVEPIFILRGFPGLEYVHSWLSILFCLAYLVAFMGNVTILSVIWIESSLHQPMYYFISIL AVNDLGMSLSTLPTMLAVLWLDAPEIQASACYAQLFFIHTFTFLESSVLLAMAFDRFVAICHPLHYPT ILTNSVIGKIGLACLLRSLGVVLPTPLLLRHYHYCHGNALSHAFCLHQDVLRLSCTDARTNSIYGLCV VIATLGVDSIFILLSYVLILNTVLDIASREEQLKALNTCVSHICVVLIFFVPVIGVSMVHRFGKHLSP IVHILMADIYLLLPPVLNPIVYSVRTKQIRLGILHKFVLRRRF*

FIG. 1 Continued

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HsOR14.1.27 (hOR11H6) nucleotide sequence (SEQ ID N0:5) a tg 11c 11 ta 11a 11CATTCTTTGGTTACTTCTGTTTTTCTAACAGCTTTGGGACCCCAGAA CAGAACAATGCATTTTGTGACTGAGTTTGTCCTCCTGGGTTTCCATGGTCAAAGGGAGATGC AGAGCTGCTTCTTCTCATTCATCCTGGTTCTCTATCTCCTGACACTGCTAGGGAATGGAGCT ATTGTCTGTGCAGTGAAATTGGACAGGCGGCTCCACACACCCATGTACATCCTTCTGGGAAA CTTTGCCTTTCTAGAGATCTGGTACATTTCCTCCACTGTCCCAAACATGCTAGTCAATATCC TCTCTGAGATTAAAACCATCTCCTTCTCTGGTTGCTTCCTGCAATTCTATTTCTTTTTTTCA CTGGGTACAACAGAGTGTTTCTTTTTATCAGTTATGGCTTATGATCGGTACCTGGCCATCTG TCGTCCATTACACTACCCCTCCATCATGACTGGGAAGTTCTGTATAATTCTGGTCTGTGTAT GCTGGGTAGGCGGATTTCTCTGCTATCCAGTCCCTATTGTTCTTATCTCCCAACTTCCCTTC TGTGGGCCCAACATCATTGACCACTTGGTGTGTGACCCAGGCCCATTGTTTGCACTGGCCTG CATCTCTGCTCCTTCCACTGAGCTTATCTGTTACACCTTCAACTCGATGATTATCTTTGGGC CCTTCCTCTCCATCTTGGGATCTTACACTCTGGTCATCAGAGCTGTGCTTTGTATTCCCTCT GGTGCTGGTCGAACTAAAGCTTTCTCCACATGTGGGTCCCACCTAATGGTGGTGTCTCTATT CTATGGAACCCTTATGGTGATGTATGTGAGCCCAACATCAGGGAACCCAGCAGGAATGCAGA AGATCATCACTCTGGTATACACAGCAATGACTCCATTCTTAAATCCCCTTATCTATAGTCTT CGAAACAAAGACATGAAAGATGCTCTAAAGAGAGTCCTGGGGTTAACAGTTAGCCAAAACTG A

HsOR14.1.27 (hOR11H6) amino acid sequence (SEQ ID N0:35)

MFF11HSLVTSVFLTALGPQNRTMHFVTEFVLLGFHGQREMQSCFFSFILVLYLLTLLGNGA IVCAVKLDRRLHTPMYILLGNFAFLEIWYISSTVPNMLVNILSEIKTISFSGCFLQFYFFFS LGTTECFFLSVMAYDRYLAICRPLHYPSIMTGKFC11LVCVCWVGGFLCYPVPIVLISQLPF CGPN11DHLVCDPGPLFALACISAPSTELICYTFNSM11FGPFLSILGSYTLVIRAVLCIPS GAGRTKAFSTCGSHLMVVSLFYGTLMVMYVSPTSGNPAGMQK11TLVYTAMTPFLNPLIYSL RNKDMKDALKRVLGLTVSQN*

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HsORl 1.13.7 (hOR4D6) nucleotide sequence (SEQ ID N0:6)

ATGGACCAGATCAACCACACTAATGTGAAGGAGTTTTTCTTCCTGGAACTTACACGTTCCCGAGAGCT

GGAGTTTTTCTTGTTTGTGGTCTTCTTTGCTGTGTATGTAGCAACAGTCCTGGGAAATGCACTCATTG

TGGTCACTATTACCTGTGAGTCCCGCCTACACACTCCTATGTACTTTCTCCTGCGGAACAAATCAGTC

CTGGACATCGTTTTTTCATCTATCACCGTCCCCAAGTTCCTGGTGGATCTTTTATCAGACAGGAAAAC

CATCTCCTACAATGGCTGCATGGCACAGATCTTTTTCTTCCACTTTGCTGGTGGGGCAGATATTTTTT

TCCTCTCTGTGATGGCCTATGACAGATACCTTGCAATCGCCAAGCCCCTGCACTATGTGACCATGATG

AGGAAAGAGGTGTGGGTGGCCTTGGTGGTGGCTTCTTGGGTGAGTGGTGGTTTGCATTCAATCATCCA

GGTAATTCTGATGCTTCCATTCCCCTTCTGTGGCCCCAACACACTGGATGCCTTCTACTGTTATGTGC

TCCAGGTGGTAAAACTGGCCTGCACTGACACCTTTGCTTTGGAGCTTTTCATGATCTCTAACAACGGA

CTGGTGACCCTGCTCTGGTTCCTCCTGCTCCTGGGCTCCTACACTGTCATTCTGGTGATGCTGAGATC

CCACTCTGGGGAGGGGCGGAACAAGGCCCTCTCCACGTGCACGTCCCACATGCTGGTGGTGACTCTTC

ACTTCGTGCCTTGTGTTTACATCTACTGCCGGCCCTTCATGACGCTGCCCATGGACACAACCATATCC

ATTAATAACACGGTCATTACCCCCATGCTGAACCCCATCATCTATTCCCTGAGAAATCAAGAGATGAA

GTCAGCCATGCAGAGGCTGCAGAGGAGACTTGGGCCTTCCGAGAGCAGAAAATGGGGG

HsORl 1.13.7 (hOR4D6) amino acid sequence (SEQ ID N0:36)

MDQINHTNVKEFFFLELTRSRELEFFLFVVFFAVYVATVLGNALIVVTITCESRLHTPMYFLLRNKSV LDIVFSSITVPKFLVDLLSDRKTISYNGCMAQIFFFHFAGGADIFFLSVMAYDRYLAIAKPLHYVTMM RKEVWVALVVASWVSGGLHS11QVILMLPFPFCGPNTLDAFYCYVLQVVKLACTDTFALELFMISNNG LVTLLWFLLLLGSYTVILVMLRSHSGEGRNKALSTCTSHMLVVTLHFVPCVYIYCRPFMTLPMDTTIS INNTVITPMLNP11YSLRNQEMKSAMQRLQRRLGPSESRKWG*

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HsOR14.2.5 (hOR4E2) nucleotide sequence (SEQ ID N0:7) atggacagtctaaaccaaacaagagtgactgaatttgtcttcttgggactcactgataaccgggtgct

Ggaaatgctgtttttcatggcattctcagccatttatatgctaacgctttcagggaacattctcatca

Tcattgccacagtctttactccaagtctccatacccccatgtatttcttcctgagcaatctgtccttt

Attgacatctgccactcatctgtcactgtgcctaagatgttggagggtttgcttttagaaagaaagac

Catttcctttgacaactgcatcacacagctcttcttcctacatctctttgcctgtgccgagatctttc

Tgctgatcattatggcgtatgatcgttacgtggctatctgcactccactccactaccccaatgtgatg

Aacatgagagtctgtatacagcttgtctttgctctctggttggggggtactgttcactcactagggca

Gaccttcttgactattcgtctaccttactgtggccccaacattattgacagctacttctgtgatgtgc

Ctcttgttatcaagctggcctgcacagatacatacctcacaggaatactgattgtgaccaatagtgga

Accatctccctctcctgtttcttggccgtggtcacctcctatatggtcatcctggtttctcttcgaaa

Acactcagctgaagggcgccgtaaagccctgtctacctgctcggcccacttcatggtggttgccctct

Tctttgggccatgtatcttcatctatactcggccagacaccagcttctccattgacaaggtggtgtct

Gtcttctacacagtggtcacccctttgctgaatcccttcatttacaccttgaggaatgaggaggtaaa aagtgccatgaagcagctcaggcagagacaagtttttttcacgaaatcatataca

HsOR14.2.5 (hOR4E2) amino acid sequence (SEQ ID N0:37)

MDSLNQTRVTEFVFLGLTDNRVLEMLFFMAFSAIYMLTLSGNIL111ATVFTPSLHTPMYFFLSNLSF IDICHSSVTVPKMLEGLLLERKTISFDNCITQLFFLHLFACAEIFLL11MAYDRYVAICTPLHYPNVM NMR VCIQLVFALWLGGTVHSLGQTFLTIRLPYCGPN11DSYFCDVPLVIKLACTDTYLTGILIVTNSG TISLSCFLAVVTSYMVILVSLRKHSAEGRRKALSTCSAHFMVVALFFGPCIFIYTRPDTSFSIDKVVS VFYTVVTPLLNPFIYTLRNEEVKSAMKQLRQRQVFFTKSYT*

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HsOR16.1.3 (hOR2C1) nucleotide sequence (SEQ ID N0:8)

ATGGACGGGGTGAATGATAGCTCCTTGCAGGGCTTTGTTCTGATGGGCATATCAGACCATCCCCAGCT

GGAGATGATCTTTTTTATAGCCATCCTCTTCTCCTATTTGCTGACCCTACTTGGGAACTCAACCATCA

TCTTGCTTTCCCGCCTGGAGGCCCGGCTCCATACACCCATGTACTTCTTCCTCAGCAACCTCTCCTCC

TTGGACCTTGCTTTCGCTACTAGTTCAGTCCCCCAAATGCTGATCAATTTATGGGGACCAGGCAAGAC

CATCAGCTATGGTGGCTGCATAACCCAGCTCTATGTCTTCCTTTGGCTGGGGGCCACCGAGTGCATCC

TGCTGGTGGTGATGGCATTTGACCGCTACGTGGCAGTGTGCCGGCCCCTCCGCTACACCGCCATCATG

AACCCCCAGCTCTGCTGGCTGCTGGCTGTGATTGCCTGGCTGGGTGGCTTGGGCAACTCTGTGATCCA

GTCAACATTCACTCTGCAGCTCCCATTGTGTGGGCACCGGAGGGTGGAGGGATTCCTCTGCGAGGTGC

CTGCCATGATCAAACTGGCCTGTGGCGACACAAGTCTCAACCAGGCTGTGCTCAATGGTGTCTGCACC

TTCTTCACTGCAGTCCCACTAAGCATCATCGTGATCTCCTACTGCCTCATTGCTCAGGCAGTGCTGAA

AATCCGCTCTGCAGAGGGGAGGCGAAAGGCGTTCAATACGTGCCTCTCCCATCTGCTGGTGGTGTTCC

TCTTCTATGGCTCAGCCAGCTATGGGTATCTGCTTCCGGCCAAGAACAGCAAACAGGACCAGGGCAAG

TTCATTTCCCTGTTCTACTCGTTGGTCACACCCATGGTGAATCCCCTCATCTACACGCTGCGGAACAT

GGAAGTGAAGGGCGCACTGAGGAGGTTGCTGGGGAAAGGAAGAGAAGTTGGCTGA

HsOR16.1.3 (hOR2C1) amino acid sequence (SEQ ID N0:38)

MDGVNDSSLQGFVLMGISDHPQLEMIFFIAILFSYLLTLLGNST11LLSRLEARLHTPMYFFLSNLSS LDLAFATSSVPQMLINLWGPGKTISYGGCITQLYVFLWLGATECILLVVMAFDRYVAVCRPLRYTAIM NPQLCWLLAVIAWLGGLGNSVIQSTFTLQLPLCGHRRVEGFLCEVPAMIKLACGDTSLNQAVLNGVCT FFTAVPLS11VISYCLIAQAVLKIRSAEGRRKAFNTCLSHLLVVFLFYGSASYGYLLPAKNSKQDQGK FISLFYSLVTPMVNPLIYTLRNMEVKGALRRLLGKGREVG*

FIG. 1 Continued

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HsOR11.13.6 (hOR5A1) nucleotide sequence (SEQ ID N0:9)

ATGTCCATAACCAAAGCCTGGAACAGCTCATCAGTGACCATGTTCATCCTCCTGGGATTCACAGACCA

TCCAGAACTCCAGGCCCTCCTCTTTGTGACCTTCCTGGGCATCTATCTTACCACCCTGGCCTGGAACC

TGGCCCTCATTTTTCTGATCAGAGGTGACACCCATCTGCACACACCCATGTACTTCTTCCTAAGCAAC

TTATCTTTCATTGACATCTGCTACTCTTCTGCTGTGGCTCCCAATATGCTCACTGACTTCTTCTGGGA

GCAGAAGACCATATCATTTGTGGGCTGTGCTGCTCAGTTTTTTTTCTTTGTCGGCATGGGTCTGTCTG

AGTGCCTCCTCCTGACTGCTATGGCATACGACCGATATGCAGCCATCTCCAGCCCCCTTCTCTACCCC

ACTATCATGACCCAGGGCCTCTGTACACGCATGGTGGTTGGGGCATATGTTGGTGGCTTCCTGAGCTC

CCTGATCCAGGCCAGCTCCATATTTAGGCTTCACTTTTGCGGACCCAACATCATCAACCACTTCTTCT

GCGACCTCCCACCAGTCCTGGCTCTGTCTTGCTCTGACACCTTCCTCAGTCAAGTGGTGAATTTCCTC

GTGGTGGTCACTGTCGGAGGAACATCGTTCCTCCAACTCCTTATCTCCTATGGTTACATAGTGTCTGC

GGTCCTGAAGATCCCTTCAGCAGAGGGCCGATGGAAAGCCTGCAACACGTGTGCCTCGCATCTGATGG

TGGTGACTCTGCTGTTTGGGACAGCCCTTTTCGTGTACTTGCGACCCAGCTCCAGCTACTTGCTAGGC

AGGGACAAGGTGGTGTCTGTTTTCTATTCATTGGTGATCCCCATGCTGAACCCTCTCATTTACAGTTT

GAGGAACAAAGAGATCAAGGATGCCCTGTGGAAGGTGTTGGAAAGGAAGAAAGTGTTTTCTTAG

HsOR11.13.6 (hOR5A1) amino acid sequence (SEQ ID N0:39)

MSITKAWNSSSVTMFILLGFTDHPELQALLFVTFLGIYLTTLAWNLALIFLIRGDTHLHTPMYFFLSN LSFIDICYSSAVAPNMLTDFFWEQKTISFVGCAAQFFFFVGMGLSECLLLTAMAYDRYAAISSPLLYP TIMTQGLCTRMVVGAYVGGFLSSLIQ ASSIFRLHFCGPN11NHFFCDLPPVLALSCSDTFLSQVVNFL VVVTVGGTSFLQLLISYGYIVSAVLKIPSAEGRWKACNTCASHLMVVTLLFGTALFVYLRPSSSYLLG RDKVVSVFYSLVIPMLNPLIYSLRNKEIKDALWKVLERKKVFS*

FIG. 1 Continued

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HsOR11.18.36 (hOR8B8) nucleotide sequence (SEQ ID N0:10)

ATGGCTGCTGAGAATTCCTCCTTCGTGACACAGTTTATCCTCGCAGGCTTAACTGACCAACC

GGGAGTCCAGATCCCCCTCTTCTTCCTGTTTCTAGGCTTCTACGTGGTCACTGTGGTGGGGA

ACCTGGGCTTGATAACCCTGATAAGGCTCAACTCTCACTTGCACACCCCTATGTACTTCTTC

CTCTATAACTTGTCCTTCATAGATTTCTGCTATTCCAGTGTTATCACTCCCAAAATGCTGAT

GAGCTTTGTCTTAAAGAAGAACAGCATCTCCTACGCAGGGTGTATGACTCAGCTCTTCTTCT

TTCTTTTCTTTGTTGTCTCTGAGTCCTTCATCCTGTCAGCAATGGCGTATGACCGCTATGTG

GCCATCTGTAACCCACTGTTGTACATGGTCACCATGTCTCCCCAGGTGTGTTTTCTCCTTTT

GTTGGGTGTCTATGGGATGGGGTTTGCTGGGGCCATGGCCCACACAGCGTGCATGATGGGTG

TGACCTTCTGTGCCAATAACCTTGTCAACCACTACATGTGTGACATCCTTCCCCTTCTTGAG

TGTGCTTGCACCAGCACCTATGTGAATGAGCTTGTAGTGTTTGTTGTTGTGGGCATTGATAT

TGGTGTGCCCACAGTCACCATCTTCATTTCCTATGCTCTCATTCTCTCCAGCATCTTCCACA

TTGATTCCACGGAGGGCAGGTCCAAAGCCTTCAGCACCTGCAGCTCCCACATAATTGCAGTT

TCTCTGTTCTTTGGGTCAGGAGCATTCATGTACCTCAAACCCTTTTCTCTTTTAGCTATGAA

CCAGGGCAAGGTGTCTTCCCTATTCTATACCACTGTGGTGCCCATGCTCAACCCATTAATTT

ATAGCCTGAGGAATAAGGACGTCAAAGTTGCTCTAAAGAAAATCTTGAACAAAAATGCATTC

TCCTGA

HsOR11.18.36 (hOR8B8) amino acid sequence (SEQ ID N0:40)

MAAENSSFVTQFILAGLTDQPGVQIPLFFLFLGFYVVTVVGNLGLITLIRLNSHLHTPMYFFLYNLSF IDFCYSSVITPKMLMSFVLKKNSISYAGCMTQLFFFLFFVVSESFILSAMAYDRYVAICNPLLYMVTM SPQVCFLLLLGVYGMGFAGAMAHTACMMGVTFCANNLVNHYMCDILPLLECACTSTYVNELVVFVVVG IDIGVPTVTIFISYALILSSIFHIDSTEGRSKAFSTCSSH11AVSLFFGSGAFMYLKPFSLLAMNQGK VSSLFYTTVVPMLNPLIYSLRNKDVKVALKKILNKNAFS*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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PCT/US2017/054620

11/97

CafaOR9.2.9 nucleotide sequence (SEQ ID N0:11)

ATGCAGTCAAAATTTGGGGCCAATAGCACAGCCATTACTGAGTTCATCCTGCTGGGCTTGGTGGACAC

ACCAGGGCTACAACCAGTTGTCTTTGTAGTCTTCCTCTTTGCCTACCTGGTCACAGTCGGAGGCAACC

TCAGCATCCTGGCTGCCATCTTGGTGGAACCCAAACTCCACACGCCCATGTACTTCTTCCTGGGGAAC

CTGTCAGTGCTGGATGTTGGGTGCATCACTGTCACTGTTCCCTCAATGTTGGCTCGCCTCTTGTCCCA

CAAACGTACAGTTCCCTACAGAGCCTGCCTCACACAACTCTTCTTCTTCCATCTCTTGGTTGGGGTGG

ACTGCTTCCTGTTGACAGCCATGGCCTATGACCGATTCCTGGCCATCTGCCGGCCCCTCACCTACAGC

ACCCAGATGAGCCAGACAGTCCAGAGAATATTGGTAGTTGTGTCCTGGGCTTTAGCCTTCACCAATGC

ACTGACCCACACAGTAGCCATAGCCACACTCAACTTTTGTGGTCCTAATGTGATCAACCACTTCTACT

GCGACCTCCCACAGCTCTTCCAGCTCTCCTGCTCCAGCACTCAGCTCAATGAGCTGCTGCTCTTTGCT

GTGGGTTTCATAATGGCAGGTACCCCCTTGGCTCTCATCATCACTTCCTATGCACATGTGGCAGCTGC

AGTCCTAAGAATCCGCTCTGCTGAGGGCAGGAAGAAAGCTTTCTCTACATGTGGCTCTCATCTCACTG

TGGTAGCCATATTCTATGGTTCAGGTATATTTAATTACATGCGACTGGGTACAGCCAAGCATTCAGAC

AAGGATAAAGGGGTTGGGGTCTTCAACACTGTCATCAACCCCATGCTGAATCCAATCATTTACAGCCT

CAGGAACCTTGATGTACAGGGTGCCCTCTGGCGGGTGCTCAGGGGAAGGCAGTCACTGGCTTGA

CafaOR9.2.9 amino acid sequence (SEQ ID N0:41)

MQSKFGANSTAITEFILLGLVDTPGLQPVVFVVFLFAYLVTVGGNLSILAAILVEPKLHTPMYFFLGN LSVLDVGCITVTVPSMLARLLSHKRTVPYRACLTQLFFFHLLVGVDCFLLTAMAYDRFLAICRPLTYS TQMSQTVQRILVVVSWALAFTNALTHTVAIATLNFCGPNVINHFYCDLPQLFQLSCSSTQLNELLLFA VGFIMAGTPLAL11TSYAHVAAAVLRIRSAEGRKKAFSTCGSHLTVVAIFYGSGIFNYMRLGTAKHSD KDKGVGVFNTVINPMLNP11YSLRNLDVQGALWRVLRGRQSLA*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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PCT/US2017/054620

12/97

CafaOR38.1.21 nucleotide sequence (SEQ ID N0:12)

ATGATGGGAAATTTGAGTGGAGGCCACATAGCAGATTTTATTTTGGTGGGCTTCCCAACCTCTCCACC

CCTCCAGTTACTTCTCTTTGTCCTCTTCTTTGCAATTTACCTGTTGACACTGTTGGAGAATGCACTCA

TCGTTTCCACAATCTGGCTCACTCCAAGCCTTCACCGCCCGATGTACTTTTTCCTTGGCCATCTGTCC

TTCCTGGAGCTGTGGTACATCAATGTCACAGTTCCTCGTCTTTTGGGAGCATTTCTTACCCAGGACCG

TAGAGTCTCCTATGTAGGCTGCATGACCCAGCTCTACTTCTTCATTGCCCTAGCCTGCACCGAATGTG

TCCTGCTGGCAGTCATGGCCTATGACCGCTACCTGGCCATCTGTGAGCCCCTCCGTTATCCTAGTCTC

ATGCCGTCCAGCCTGGCCATTCGCCTTGCTGCTTCCTCTTGGGGTGGTGGCTTCTTCAGCTCCATGAT

GAAGCTTCTTTTCATTTCCCGACTGTCCTACTGTGGGCCCAACATCATCAACCATTTTTTCTGTGATA

TCTCCCCACTACTCAACCTTACCTGCTCTGACAAGGAGCAAGCAGAACTAGTAGACTTCCTGTTGGCC

CTGGTGATGATCCTGCTTCCTCTACTGGCTGTGGTTTCATCATATGCTGCCATCATTGCCACCATCCT

GAGGATCCCTACTGCCCAGGGACGTCGCAAAGCCTTTTCCACCTGTGCCTCTCACCTGGCAGTGGTTG

TCATCTACTACTCCTCCACCCTCTTCACCTATGCAAGGCCCCGGGCCATGTACACCTTCAACCACAAC

AAGATCATCTCTGTGCTCTATACGGTCATTGTACCATTCCTCAATCCAGCCATCTACTGCCTGAGGAA

CAAGGAGGTGAAGGATGCTCTCAGGAAGTTGGTTCTGGGCAGATGCCACTATCCTAGTGATGTCCCAG

ACTGA

CafaOR38.1.21 amino acid sequence (SEQ ID N0:42)

MMGNLSGGHIADFILVGFPTSPPLQLLLFVLFFAIYLLTLLENALIVSTIWLTPSLHRPMYFFLGHLS FLELWYINVTVPRLLGAFLTQDRRVSYVGCMTQLYFFIALACTECVLLAVMAYDRYLAICEPLRYPSL MPSSLAIRLAASSWGGGFFSSMMKLLFISRLSYCGPN11NHFFCDISPLLNLTCSDKEQAELVDFLLA LVMILLPLLAVVSSYAA11ATILRIPTAQGRRKAFSTCASHLAWVIYYSSTLFTYARPRAMYTFNHN K11SVLYTVIVPFLNPAIYCLRNKEVKDALRKLVLGRCHYPSDVPD*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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PCT/US2017/054620

13/97

CafaOR21.2.15 nucleotide sequence (SEQ ID N0:13)

ATGGTGGACCCCAATGGCAATGAATCCAGTGCCACATATTTTATTTTAATAGGCCTCCCAGGCTTGGA

AGAAGCTCAGTTCTGGTTGGCCTTCCCCTTGTGCTCCCTCTACTTTATTGCTGTATTGGGTAACCTGA

CAATCATCTACATTGTGCGGACTGAGCACAGCCTACATGAACCCATGTATGTTTTTCTTTGCATGCTT

TCTGGCCTTGACATCCTTATCTCCACCTCATCTATGCCCAAAATGATGGCCATCTTCTGGTTCAATTC

CACTACCATCCAGTTTGATGCTTGTCTACTACAGATGTTTGCCATCCATTCTTTATCTGGCATGGAGT

CCACAGTACTGCTGGCCATGGCCTTTGACCGCTATGTGGCCATTTGCCACCCACTACGCCATGCCACT

GTACTAACATTGCCTCGTGTTATGAAGATTGGCATGGCTGCTGTGGTACGGGGTACTGCACTTATGGC

ACCCCTGCCTGTTTTTATCAAACGACTGCCTTTCTGCCACTCCAACATTCTTTCCCATTCCTACTGCC

TACACCAAGATGTCATGAAGCTGGCTTGTGCTGACATCCGTGTCAATATCATCTATGGCCTCATTGTC

ATCATCTCTGCCATTGGCCTGGACTCACTTCTCATCTCCTTGTCATATCTACTTATCCTCAAGACTGT

GTTGGGCTTGACACGTGAAGCCCAGGCAAAGGCATTTGGCACTTGTGTCTCTCATGTATGTGCTGTTT

TCATATTCTATGTACCTTTCATTGGATTATCTATGGTGCACCGCTTTGGCAAGAGACATGACTCCTTC

CTGCCCATCATTATGGCCAACACCTACCTACTTGTACCTCCTGTGCTCAACCCCATTGTTTATGGAGT

CAAGACAAAGGAGATCTGGCAGCGTATCCTTCGTCTTTTCCATGTGACCAACCATACTTCAGATCTCT

AG

CafaOR21.2.15 amino acid sequence (SEQ ID N0:43)

MVDPNGNESSATYFILIGLPGLEEAQFWLAFPLCSLYFIAVLGNLT11YIVRTEHSLHEPMYVFLCML SGLDILISTSSMPKMMAIFWFNSTTIQFDACLLQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHAT VLTLPRVMKIGMAAVVRGTALMAPLPVFIKRLPFCHSNILSHSYCLHQDVMKLACADIRVN11YGLIV 11SAIGLDSLLISLSYLLILKTVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFGKRHDSF LP11MANTYLLVPPVLNPIVYGVKTKEIWQRILRLFHVTNHTSDL*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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PCT/US2017/054620

14/97

CafaOR21.2.43 nucleotide sequence (SEQ ID N0:14)

ATGCCAAGGGTCACCATGGTGGTCTGGAATAACAATAACACTCTGGAGCCCATATTTATTCTGAAGGG

ATTTCCTGGGTTGGAGTGTGTTCATTCTTGGTTCTCAATCCCTTTCTGTCTTGCGTACTTGGTAGCAT

TTATTGGTAATGTCACCATCCTCTCTGTCATCTGGATAGAGTCCTCACTCCACCAGCCCATGTATTAC

TTTCTTTCCATCTTGGCACTGACTGACCTAGGCATGTCCATGTCCACACTTCCCACCATGCTTGCTGT

GTTATGGCTGGATGCTAGAGAGATCCAGGCAAGTGCTTGCTATGCTCAGCTCTTCTTCATCCACACAT

TCACATTCCTGGAGTCTTCGGTGCTATTGGCCATGGCCTTCGATCGTTTTGTTGCTATCTGCCGTCCA

CTGCACTACACCACCATCCTTAACAACAGTGTAATAGGCAAGATTGGCTTGGCCTGCTTGCTAAGAAG

CATGGGAGTTGTACTTCCTACACCTTTGCTACTGAGACATTATCACTACTGCCATGTCAATGCCCTTT

CCCATGCCTTCTGTTTGCACCAAGACGTTCTCAAATTGTCCTGTTCAGATGCCAGGATCAGCAGTGTC

TATGGACTGTGTGTAGTCATCACTACACTGGGCATGGATTCAGTCTTCATACTTCTTTCTTATGTCCT

GATTTTGAATGCTGTGCTGGGCATAGCATCTCATGAAGAGCGGCTAAAGGCACTCAACACATGTGTGT

CCCATATCTGCGTGGTGCTCATTTTCTTTGTGCCAGTTATTGGGGTGTCAATGGTCCATCGCTTTGGG

AAACATCTGTCTCCCATAGTTCACATCATCATGGCTGATATTTACTTGCTTTTCCCCCCAGTACTTAA

CCCTATTGTCTATAGTGTCAGGACAAAGCAGATTCGTATAAGAATTTTCCACAAGTTAAGACTAGGGA

GGAGGCTTTAA

CafaOR21.2.43 amino acid sequence (SEQ ID N0:44)

MPRVTMVVWNNNNTLEPIFILKGFPGLECVHSWFSIPFCLAYLVAFIGNVTILSVIWIESSLHQPMYY FLSILALTDLGMSMSTLPTMLAVLWLDAREIQASACYAQLFFIHTFTFLESSVLLAMAFDRFVAICRP LHYTTILNNSVIGKIGLACLLRSMGVVLPTPLLLRHYHYCHVNALSHAFCLHQDVLKLSCSDARISSV YGLCVVITTLGMDSVFILLSYVLILNAVLGIASHEERLKALNTCVSHICVVLIFFVPVIGVSMVHRFG KHLSPIVH11MADIYLLFPPVLNPIVYSVRTKQIRIRIFHKLRLGRRL*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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PCT/US2017/054620

15/97

CafaORI 5.2.20 nucleotide sequence (SEQ ID N0:15)

ATGCTCATCATTATTCACTCATTGGTTATCTCTGCTTCTCTAACAGCTTTGGAATCCCAGAACACAAC

AATGCGTTTTGTGTCTGAGTTTGTCCTCCTGGGTTTCCCTGGTCAAAGGGAGATGCAGAACTTTTTCT

TCTCATTCATCCTGGTGATCTATCTCCTCACCCTGCTGGGGAATGGGATTATTGTCTGCATAGTGAAA

TGGGACAAGCAGCTTCACACACCCATGTACATCTTCTTGGGAAACTTTGCCTTCCTAGAGATCTGGTA

CACCTCCTCCACTGTCCCAAGTATGCTGGTCAACATCCTTTCCGAGACCAAGACCATCTCCTTCACTG

GGTGCTTCCTTCAATTCTACTTCTTTTTCTCACTGGGTACAACAGAGTGTTTCTTCTTATCAGTCATG

GCTTATGATCGGTACCTCGCCATCTGTCGCCCACTCCATTACCCCTCCATCATGACTGGGAAGCTCTG

TGTGGCCCTGGTCTGTGTTTGCTGGGTGAGTGGATTTCTCTGCTATCCAGTCCCCATTGTCCTCATCT

CCCAACTTCCATTCTGTGGACCCAACATCATTGATCACTTTGTGTGTGACCCAGGCCCACTGTTCGCA

CTGGCCTGCATCCCTGCTCCTTCCACTGAGCTTCTCTGTTACACCTTCAATTCACTGATTATCTTCGG

GCCCTTCCTCTTCATCCTGGGATCTTACACCCTGGTTCTCAGAGCTGTGCTTCGCATTCCTTCTGGTG

CAGGTCGAACTAAAGCATTCTCCACGTGTGGGTCCCATCTAATGGTGGTGTCTCTATTCTATGGAACC

CTTATGGTGATGTATGTGAGCCCGACATCAGGGAATCCGACGGGAATGCAAAAGATCATCACTCTGGT

ATACTCGGCAGTGACTCCACTCTTAAACCCCCTTATCTATAGTCTCCGAAACAAAGACATGAAAGATG

CCCTAAAGAAAGTCCTAGGATTAAGAAGTAACCAAAACTGA

CafaORI 5.2.20 amino acid sequence (SEQ ID N0:45)

ML111HSLVISASLTALESQNTTMRFVSEFVLLGFPGQREMQNFFFSFILVIYLLTLLGNG11VCIVK WDKQLHTPMYIFLGNFAFLEIWYTSSTVPSMLVNILSETKTISFTGCFLQFYFFFSLGTTECFFLSVM AYDRYLAICRPLHYPSIMTGKLCVALVCVCWVSGFLCYPVPIVLISQLPFCGPN11DHFVCDPGPLFA LACIPAPSTELLCYTFNSL11FGPFLFILGSYTLVLRAVLRIPSGAGRTKAFSTCGSHLMVVSLFYGT LMVMYVSPTSGNPTGMQK11TLVYSAVTPLLNPLIYSLRNKDMKDALKKVLGLRSNQN*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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PCT/US2017/054620

16/97

CafaORl 8.3.11 nucleotide sequence (SEQ ID N0:16)

ATGGGCCAGAGCAACCACACCAATGTGAAGGAATTTGTCTTTCTGAAACTCACTCACTTCCACGAGCT

AGAATTGTTCTTGTTTGTGGTCTTCCTTGCTGTATATGTAGCAACTGTGCTGGGCAATGTCCTCATTG

TGGTGACCATCACCTGTGAGTCCCACCTCCACTCTCCCATGTACTTTCTGCTGCGGAACAAATCAGTC

CTGGACATTGTCTTTTCATCTGTCACTGTTCCCAAGTTCCTGGTGGATCTGTTATCAGAGAGAAAAAC

CATCTCCTACAATGGCTGCATGGCACAGATCTTCTTCTTCCACTTCGCTGGTGGGGCAGACATTTTCT

TCCTCTCTGTGATGGCCTATGACAGGTACCTTGCAATCGCCAAACCCCTGCATTATGTGACCATTATG

AGGAGAGAGACGTGGGTGGGCTTGGTGGTGGCTTCCTGGGTGGGTGGTGGTTTGCACTCAATTGTCCA

GGTAACTCTCATGCTTCCACTCCCTTTCTGTGGCCCCAACATCCTGGATGCCTTCTACTGTGATGTGC

CCCAAGTGATTAAGCTGGCCTGTACCAACACCTTTGCCCTGGAGCTTCTCATGATCTCTAACAATGGG

CTGGTGACCCTGCTGTGGTTCCTCCTGCTCCTGGGCTCCTACACTGTCATTCTGGTGATGCTGAGATC

TCACTCTGGGGAGGGGCGGAATAAGGCCCTGTCCACCTGCACTTCCCATATCTTCGTGGTGACCCTGC

ACTTCGTGCCTTGCGTCTACATCTACTGCCGGCCCTTCATCACGCTGCCCATGGACACAGTTGTATCC

ATCAATAACACAGTCATTACCCCCATGCTGAACCCCATGATCTATACACTGAGGAACCAGGAGATGAA

GTCAGCCATGAAAAGACTGCAGAGAAGGCTTGGACCTTCTGAGAGCAGTTAG

CafaORl 8.3.11 amino acid sequence (SEQ ID N0:46)

MGQSNHTNVKEFVFLKLTHFHELELFLFVVFLAVYVATVLGNVLIVVTITCESHLHSPMYFLLRNKSV LDIVFSSVTVPKFLVDLLSERKTISYNGCMAQIFFFHFAGGADIFFLSVMAYDRYLAIAKPLHYVTIM RRETWVGLVVASWVGGGLHSIVQVTLMLPLPFCGPNILDAFYCDVPQVIKLACTNTFALELLMISNNG LVTLLWFLLLLGSYTVILVMLRSHSGEGRNKALSTCTSHIFVVTLHFVPCVYIYCRPFITLPMDTVVS INNTVITPMLNPMIYTLRNQEMKSAMKRLQRRLGPSESS*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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PCT/US2017/054620

17/97

CafaORI 5.3.1 nucleotide sequence (SEQ ID N0:17)

ATGGAGGCTCCGAATCAAACAAGAGTGACTGAGTTTGTCTTCTTGGGGCTCACAGATAACTGGGCGCT

GGGGACGCTACTTTTTGTGGCATTCTCCCTGGCTTATGTGCTCACCCTTCTGGGGAACACTCTCATCA

TAGTGACCACGGCCCTTACCCGGCGCCTCCATACCCCCATGTACTTCTTCCTGAGCAACCTGTCCTTC

ATTGACACCTGCCACTCCTCGGTCACTGTGCCCAAGATGCTGGAGGGCCTGCTTAGGGAGAGAAAGAC

TATTTCCTTTGATGACTGCATTGCGCAGCTCTTCTTCCTACACCTGTTCGCTTGTGCTGAGATCCTTC

TGCTGACCGTCATGGCTTACGACCGCTACGTGGCCATCTGTGCCCCGCTGCGCTACCCCAACGTGATG

AGCATCCGGGTGTGTGTGCAGCTCGTCCTCGCCCTCTGGTGGGGGGGTACCGTTCACTCTCTGGTGCA

GACCCTCCTGACCATTCGTTTGCCCTACTGCGGCCCCAACGTTATCGATAGCTACTTCTGCGATGTGC

CCCCCGTCATCAAGCTGGCCTGCACGGACACCTACCTCACGGGAGTGCTCATTGTCTCCAACAGTGGA

ACCATCTCCCTCACCTGTTTCCTGGCTTTGGTCACCTCTTACACAATCATCCTGGTGTCTCTTAGAAA

ACAGTCTGCTGAAGGGCGCCGGAAAGCTCTGTCTACGTGCTCAGCCCACTTCATGGTGGTCGCCTTCT

TCTTTGGACCATGCATCTTCATCTACACTCGGCCAGACACCAGCTTCTCCATCGACAAGGTGGTATCT

GTCTTCTACACCGTGGTCACCCCTTTGCTAAATCCCCTCATTTACACCTTGAGGAATGAGGAGGTAAA

AAGTGCCATAAAGCATCTCAGACAGAAACAGGTTTTCTCATAA

CafaORI 5.3.1 amino acid sequence (SEQ ID N0:47)

MEAPNQTRVTEFVFLGLTDNWALGTLLFVAFSLAYVLTLLGNTL11VTTALTRRLHTPMYFFLSNLSF IDTCHSSVTVPKMLEGLLRERKTISFDDCIAQLFFLHLFACAEILLLTVMAYDRYVAICAPLRYPNVM SIRVCVQLVLALWWGGTVHSLVQTLLTIRLPYCGPNVIDSYFCDVPPVIKLACTDTYLTGVLIVSNSG TISLTCFLALVTSYT11LVSLRKQSAEGRRKALSTCSAHFMVVAFFFGPCIFIYTRPDTSFSIDKVVS VFYTVVTPLLNPLIYTLRNEEVKSAIKHLRQKQVFS*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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PCT/US2017/054620

18/97

CafaOR6.3.1 nucleotide sequence (SEQ ID N0:18)

ATGCCAGAGGCCAACGACAGCTTCCTGGAGGGCTTCATTCTGATGGGTATATCTGACCATCCCCAGCT

GGAGATAATCTTTTTCATGGTCATTCTCTTCTCTTACTTACTGACTCTGCTTGGGAACTCAACCATTA

TCCTGCTTTCCTGGCTGGATGCCCGGCTCCATACTCCCATGTACTTCTTCCTCAGCAACCTCTCCACC

CTGGACCTTGCTTTTACTACTAGCTCAGTCCCCCAAATGCTGATCAACTTATGGGGACCAGATAAGAC

CATAAGCTATGGTGGCTGTGTGACCCAGCTCTATGTTTTCCTCTGGCTAGGGGCCACTGAGTGTATCC

TGCTTGTGGTGATGGCGTTTGACCGCTATGTGGCAGTTTGCCGGCCCCTGCACTACACCACCATCATG

AACCCTCGGCTCTGCTGGCTGCTGGCTGCCATTGCATGGCTGGGTGGCTTGAGCAACTCTGTGATCCA

GTCAACCTTCACTCTGCAGCTCCCCTTATGTGGGCACCGGAGGGTGGACAACTTCCTGTGTGAGGTAC

CTGCCATGATCAAACTGGCCTGTGGAGACACGAGTCTCAATGAGGTTGTGCTCAATGGTGTCTGCACC

TTCTTCACTGCTGTCCCACTAAGTGTCATCCTGATCTCCTACTGCTACATAGCTCAGGCAGTGCTGAA

GATCCACTCAGTAGAGGGACAGAGAAAGGCCTTTAATACGTGCCTCTCACATCTGGTGGTGGTGTTGC

TCTTCTATGGCTCAGCTATCTATGGGTATCTCCTTCCAGCTAAGACCAGCAACCAGGACCAGGGCAAA

TTCATTTCCCTCTTCTACTCTGTGGTCACACCAACGGTGAACCCTCTCATCTACACTCTGAGAAATAG

GGAAGTAAAGGGAGCACTAAGGAGGCTGCTAGGAAAGGGAAGATCACTTGGCTGA

CafaOR6.3.1 amino acid sequence (SEQ ID N0:48)

MPEANDSFLEGFILMGISDHPQLE11FFMVILFSYLLTLLGNST11LLSWLDARLHTPMYFFLSNLST LDLAFTTSSVPQMLINLWGPDKTISYGGCVTQLYVFLWLGATECILLVVMAFDRYVAVCRPLHYTTIM NPRLCWLLAAIAWLGGLSNSVIQSTFTLQLPLCGHRRVDNFLCEVPAMIKLACGDTSLNEVVLNGVCT FFTAVPLSVILISYCYIAQAVLKIHSVEGQRKAFNTCLSHLVVVLLFYGSAIYGYLLPAKTSNQDQGK FISLFYSVVTPTVNPLIYTLRNREVKGALRRLLGKGRSLG*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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19/97

CafaORI 8.3.12 nucleotide sequence (SEQ ID N0:19)

ATGTCCACAGTTAAGGCCTGGAACAGCTCTTCAGTGACCATGTTCATCCTCCTGGGATTTGCAGACCA

TCCAGAACTGCAGACTCTTCTCTTTGTGACCTTCCTGAGTATCTATCTTGTGACACTGGCCTGGAACC

TGGCCCTCATCTTTCTGATCAGAAGTGACCCCCATCTGCACACACCCATGTACTTCTTCCTCAGCAAC

TTGTCCTTCATTGACATCTGTTATTCTTCCACAGTGGCCCCCAAGATGCTCACTGATTTCTTCCAGGA

GCAAAAGACCATCTCGTTCTTGGGCTGTGCTGCTCAGTTTTTTTTCTTTGTCAGCATGGGTCTCACTG

AGTGCTTCCTTCTGACTGCCATGGCATATGATCGATACGCAGCCATCTCCAACCCCTTGCTCTACACT

GCCATCATGTCCCAGGGCCTCTGTACACGCATGGTGCTGGGGGCATATGTCGGTGGTTTCCTGAGCTC

CTTGATCCAGGCCATCTCTATATTTCAGCTCCACTTCTGTGGACCCAATATCATCAACCATTTCTTCT

GTGACCTTCCACCAGTCCTGGCACTTTCTTGCTCTGACACCTTCCCTAGTCAAGTGGTGAATTTTCTC

ATAGTGATCACTGTTGGGGGAACATCATTCCTCATCCTCCTCATCTCCTACAGTTACATAGGAGCTGC

TGTCTTGAAGATCCGCTCAGTGGAAGGCCGAAGGAAAGCCTTCAACACATGTGCCTCGCATCTGATGG

TGGTGACTCTTCTGTTTGGGACAGCTCTTTTCATGTACCTGCGGCCCAGCTCCAGCTACTCACTTGCC

AGGGACAAGGTGGTGTCTGTCTTCTATTCGCTGGTGATCCCCATGCTGAACCCTCTCATTTACAGTCT

AAGGAACAGAGATATCAAAGACGCCCTGTGGAAGGCATTGGAGAAGAAGAAAGTGTTTTTCCTAGATC

ATGATTGA

CafaORI 8.3.12 amino acid sequence (SEQ ID N0:49)

MSTVKAWNSSSVTMFILLGFADHPELQTLLFVTFLSIYLVTLAWNLALIFLIRSDPHLHTPMYFFLSN LSFIDICYSSTVAPKMLTDFFQEQKTISFLGCAAQFFFFVSMGLTECFLLTAMAYDRYAAISNPLLYT AIMSQGLCTRMVLGAYVGGFLSSLIQAISIFQLHFCGPN11NHFFCDLPPVLALSCSDTFPSQVVNFL IVITVGGTSFLILLISYSYIGAAVLKIRSVEGRRKAFNTCASHLMVVTLLFGTALFMYLRPSSSYSLA RDKVVSVFYSLVIPMLNPLIYSLRNRDIKDALWKALEKKKVFFLDHD*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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20/97

CafaOR5.2.5 nucleotide sequence (SEQ ID N0:20)

ATGCCTTTAGTAAGAATGGCAGCTGAGAATTCCTCTGTGACAGAGTTTATCCTCTCAGGCTTAACCAA

CCAGCCAGGACTCCAGATTCCTCTCTTCTTCCTGTTTCTAGGTTTCTATGTGGTCACGGTGGTAGGGA

ACCTGGGCCTGATAACCCTGATTGGGCTGAATTCTCACCTGCACACCCCCATGTACTTTTTCCTCTTC

AACTTGTCCTTCATAGATTTCTGCTATTCCACTGTTATCACTCCCAAGATGCTGATGAATTTTGTCTT

GAGGAAGAACGTCATCTCCTACGCAGGGTGTATGACTCAGCTCTTCTTCTTTCTCTTCTTTGTTGTAT

CTGAGTCCTTCATCCTGTCAGCAATGGCATATGACCGCTATGCCGCCATCTGTAACCCACTGGTATAC

ACTGCCACCATGTCTCCTCAGGTCTGCTTCCTCCTTCTGTTGGGTGTCTATGTGATGGGGTTTGCTGG

AGCCATGGCCCACACAGTGTGCATGGTAAGACTGACCTTCTGTGCCAACAATCTGGTTGACCACTACA

TGTGCGACATCCTTCCCCTTCTTGAGCGTTCTTGCACCAGCACCTATGTCAATGAGCTGGTAGTTTTT

ATTGTTGTGGGCATTGATATTGGTGTGCCCACAGTTACCATCTTCATTTCTTATGCCCTCATCCTCTC

CAGCATTCTCCGTATTCATTCTACCAAGGGCAGGTCCAAAGCCTTCAGCACCTGCAGCTCCCACATAA

TTGCTGTTTCCCTCTTCTTTGGATCAGGGGCATTTATGTACCTCAAACCATCCTCTCTTTTACCTATG

AATCAGGGGAAAGTGTCCTCTTTGTTCTACACCATCGTTGTGCCCATGCTCAACCCACTAATCTACAG

CTTGAGGAATAAGGATGTCAAAATTGCTCTGAAGAAAACACTGAGCAAGAAACCATTCTCTTGA

CafaOR5.2.5 amino acid sequence (SEQ ID N0:50)

MPLVRMAAENSSVTEFILSGLTNQPGLQIPLFFLFLGFYVVTVVGNLGLITLIGLNSHLHTPMYFFLF NLSFIDFCYSTVITPKMLMNFVLRKNVISYAGCMTQLFFFLFFVVSESFILSAMAYDRYAAICNPLVY TATMSPQVCFLLLLGVYVMGFAGAMAHTVCMVRLTFCANNLVDHYMCDILPLLERSCTSTYVNELVVF IVVGIDIGVPTVTIFISYALILSSILRIHSTKGRSKAFSTCSSH11AVSLFFGSGAFMYLKPSSLLPM NQGKVSSLFYTIVVPMLNPLIYSLRNKDVKIALKKTLSKKPFS*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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E1:13347030-13347977 nucleotide sequence (SEQ ID N0:21) atgaagtcaaaattTGAGTACAATAGAACAGCCATTACTGAGTTCATCCTGCTGGGCTTAGT GGAGACACCAGACCTGCGGCCAGTTGTCTTTGTAGTCTTCCTCCTTTCCTACCTGCTCACAG TTGGGGGCAACCTCAGCATCCTGGCCGCCATCTTGGTGGagcccaaactccacacccccatg tacttcttcctggggAACCTATCGGTGCTGGACATTGGGTGCATCACAGTCACTATTCCCTC AATGTTGGCTCGTCTCCTGTCCCACAAGCGTACTGTTCCCTATGGAGCCTGCCTCACACAGC TTTTCTTCTTTCACCTTCTCGTTGGGGTGGACTGCTTCCTTTTGACAGCCATGGCCTATGAC CGATTCCTGGCCATCTGCCAGCCCCTCACCTACAGCACCCGAATGAGCCAGACAGTCCAGAG GATATTGGTGGCTGTGTCCTGGGCTTTAGCCTTCACTAATGCACTGACCCACACAGTAGCCA TATCCACCCTGAACTTCTGTGGTCCCAATGTGATCAATCACTTCTACTGTGACCTCCCACAG CTCTTCCAGCTCTCCTGCTCCAGCACCCAACTCAATGAGTTGCTGCTCTTTGCTGTGGGTTT CATAATGGCAGGTACTCCCCTGGCTCTCATCGTCACCTCCTATGCCCATGTGACAGCTGCAG TCCTACGAATCCGTTCTGCTGAGGGCAGGAAGAAAGCCTTCTCCACATGTGGCTCTCATCTC ACTGTGGTTGCCATATTCTACGGTTCAGGTATATTTAATTACATGCGACTGGGTTCAGCCAA GCTTTCAGACAAGGATAAAGCTTTTGGAATTTTTAACACCGTCATCAACCCCATGCTGAATC CAATCATCTACAGCCTCAGGAACCCTGACGTGCAGGGTGCCCTCTGGAGAGTGCTCATGGGG AGGCGGCCACTGGCTTGA

E1:13347030-13347977 amino acid sequence (SEQ ID N0:51)

MKSKFEYNRTAITEFILLGLVETPDLRPVVFVVFLLSYLLTVGGNLSILAAILVEPKLHTPM YFFLGNLSVLDIGCITVTIPSMLARLLSHKRTVPYGACLTQLFFFHLLVGVDCFLLTAMAYD RFLAICQPLTYSTRMSQTVQRILVAVSWALAFTNALTHTVAISTLNFCGPNVINHFYCDLPQ LFQLSCSSTQLNELLLFAVGFIMAGTPLALIVTSYAHVTAAVLRIRSAEGRKKAFSTCGSHL TWA IF YGSGIFN YMRLGS AKLSDKDK AFGIFNT VINPMLNP11YSLRNPD VQG ALWR VLMG RRPLA*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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F1:65134904—65135858 nucleotide sequence (SEQ ID N0:22)

ATGGGAAATTGGAGCAGAGGCCACATAGCAGAGTTCGTGTTGGTGGGCTTCCCTACCTCTCCGCCCCT

CCAGTGCCTCCTCTTTGTCCTCTTCCTGGCAATTTACCTGTTGACATTGTTGGAGAACGCACTCATCG

TTTCCACAGTCTGGCTCACGCCAAGCCTTCACCGCCCGATGTACTTTTTCCTTGGCCATCTCTCCTTC

CTGGAGCTGTGGTACATCAATGTCACAGTTCCCCGGCTTTTGGGAGCATTTCTTACCCAGGAGCGTAG

AGTCTCCTACGTAGGCTGCATGACTCAGCTCTACTTCTTTATTGCCCTAGCCTGCACCGAATGTGTCC

TGCTGGCGgtcatggcctatgaccgctaccTGGCCATCTGTGAGCCCCTCCGTTATCCTAGTCTCATG

CCATCCAGCCTGGCCATTCGCCTCGCTGCTTCCTCTTGGGGTAGTGGCTTCTTGAGCTCCATGATGAA

GCTTCTTTTCATTTCCCGGCTGTCCTACTGTGGACCCAACGTCATCAACCACTTTTTCTGCGATATCT

CCCCACTACTCAACCTCACCTGCTCTGACAAAGAGCAAGCAGAACTAGTAGACTTCCTCTTGGCCCTG

GTGATGATTCTGCTCCCTCTGTTGGCCGTGGTTTCATCATATGCTGCCATAATGGCTGCCATCCTCAG

GATTCCTACTGCCCAGGGACGTCGcaaagccttctccacctgtgccTCTCACCTGGCAGTGGTTGTTA

TCTACTACTCCTCCACCCTCTTCACCTATGCACGGCCCCAGGCCATGTACACCTTCAACCATAACAAG

GTCATCTCTGTGCTCTATACAGTCATTGTACCGTTCCTCAATCCAGCCATCTACTGCCTGAGGAACAA

GGAGGTGAAGGATGCTCTCAGGAAGTCAGTCCTGGGCAGATGCCACTATCCGAGGGACGTCCCAGATT

GA

F1:65134904-65135858 amino acid sequence (SEQ ID N0:52)

MGNWSRGHIAEFVLVGFPTSPPLQCLLFVLFLAIYLLTLLENALIVSTVWLTPSLHRPMYFFLGHLSF LELWYINVTVPRLLGAFLTQERRVSYVGCMTQLYFFIALACTECVLLAVMAYDRYLAICEPLRYPSLM PSSLAIRLAASSWGSGFLSSMMKLLFISRLSYCGPNVINHFFCDISPLLNLTCSDKEQAELVDFLLAL VMILLPLLAVVSSYAAIMAAILRIPTAQGRRKAFSTCASHLAWVIYYSSTLFTYARPQAMYTFNHNK VISVLYTVIVPFLNPAIYCLRNKEVKDALRKSVLGRCHYPRDVPD*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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D1:62955839-62956792 nucleotide sequence (SEQ ID N0:23)

ATGGTGGACACCAATGGCAGTGAATCTAGTGCCACATATTTCATTCTAATAGGCCTTCCAGGCTTGGA

AAAAGCTCAGTTCTGGTTGGCCTTCCCGTTATGCTCCCTCTACCTTATTGCTGTGCTAGGTAACCTGA

CAGTCATCTGCATTGTGCGGACTGAGCACAGACTACATGAAcccatgtatatttttctttgcatGCTT

TCTGGCCTTGACATACTTATCTCTACTTCATCTATGCCCAGAATGATGGCCATCTTCTGGTTCAATTC

CACTACCATCCAGTTTGATGCTTGTCTTCTACAGATGTTTGCCATCCACTCCTTATCTGGCATGGAGT

CCACTGTACTGCTGGCCATGGCCTttgaccgctatgtggccattTGTCACCCACTACGCCATGCCACT

GTGCTAACATTGCCTCGTGTTACCAAGATTGGCGTGGCTGCTGTGGTACGGGGTACTTCACTTATGGC

ACCCCTGCCTATCTTCATCAAACGGCTGCCTTTCTGCCGCTCCAACATTCTTTCCCATTCCTACTGCC

TACATCAAGATGTCATGAAGCTGGCTTGTGCTGACATCCGTGTCAATATCATCTATGGCCTCATTGTC

ATCATCTCTGCCATTGGCCTGGACTCACTTCTCATCTCCTTGTCATATCTGCTTATCCTCAAGACTGT

GTTGGGCTTGACACGTGAAGCCCAGGCAAAGGCATTTGGCACTTGTGTCTCTCATGTGTGTGCTGTTT

TCATATTCTATGTACCTTTCATTGGGTTATCTATGGTGCACCGCTTTGGGAAGCGGCATGACTCCCTC

CTGCCCATCATTATGGCCAACACCTACTTGCTTGTTCCTCCTGTGCTCAACCCTATTGTTTATGGAGT

GAAGACAAAGGAGATCCGGCAGCGTATCCTTCGTCTTTTCCATGTGACCACCCATACTTCAGATCCCT

AG

D1:62955839-62956792 amino acid sequence (SEQ ID N0:53)

MVDTNGSESSATYFILIGLPGLEKAQFWLAFPLCSLYLIAVLGNLTVICIVRTEHRLHEPMYIFLCML SGLDILISTSSMPRMMAIFWFNSTTIQFDACLLQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHAT VLTLPRVTKIGVAAVVRGTSLMAPLPIFIKRLPFCRSNILSHSYCLHQDVMKLACADIRVN11YGLIV 11SAIGLDSLLISLSYLLILKTVLGLTREAQAKAFGTCVSHVCAVFIFYVPFIGLSMVHRFGKRHDSL LP11MANTYLLVPPVLNPIVYGVKTKEIRQRILRLFHVTTHTSDP*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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D1:63312327-63313289 nucleotide sequence (SEQ ID N0:24)

ATGCCAAGGTTCACCATGGTGGTCTGGAATAACAATAACACCATGGAGCCTATATTTATTCTGAGGGG

ATTTCATGGATTGGAGTGTGTCTATTCTTGGATCTCAGTCCCATTCTGTCTTGCATACTTGGTAGCAT

TTATTGGTAATGTTACCATCCTCTCTGTCATTTGGATAGAGTCATCACTCCATCAGCCCATGTACTAC

TTCCTTTCCATCTTGGCACTGACTGACCTAGGTATGTCTATGTCCACACTTCCCACCATGCTTGCTGT

GTTATGGCTGGATGCTCGGGAGATCCAGGCAAGTGCTTGCTATGCTCAGCTCTTTTTCATCCACACAT

TCACATTCCTGGAGTCTTCGGTGCTACTGGCCATGGCCTTTGACCGTTTTGTTGCTATCTGCCGTCCA

CTGCACTATACTACCATCCTTAACAACAGTGTAATAGGCAAGATTGGTTTGGCCTGCTTGCTAAGAAG

CATGGGAGTTGTACTTCCTACACCTTTGCTACTGAGACATTATCACTACTGCCATGACAATGCCCTTT

CCCATACCTTCTGTTTGCACCAAGACATTCTGAAATTATCCTGTTCAGATGCAAGGATCAGCAGTGTC

TATGGCCTGTGTGTAGTTATTACCACACTTGGTGTGGATTCAGTCTGCATACTTCTTTCTTATATCCT

GATTCTGAATGCTGTGCTGGGGATTGCATCTCATGAAGAGCGGCGGAAGGCACTCAACACATGCATAT

CCCATATCTGTGTTGTGCTCATTTTCTTTGTGCCAGTAATTGGGGTGTCAATGGTCCATCGCTTTGGG

AAACATCTGTCTCCAAGAATTCACATCATCATGGCCGATATTTACCTGCTTTTCCCCCCAGTGCTTAA

CCCTATTGTCTATAGCATCAAAACAAAGCAGATTCGTCTAAGAATTCTCCGCAGGTTTGGACTGCGGA

GGGGGCATTAA

D1:63312327-63313289 amino acid sequence (SEQ ID N0:54)

MPRFTMVVWNNNNTMEPIFILRGFHGLECVYSWISVPFCLAYLVAFIGNVTILSVIWIESSLHQPMYY FLSILALTDLGMSMSTLPTMLAVLWLDAREIQASACYAQLFFIHTFTFLESSVLLAMAFDRFVAICRP LHYTTILNNSVIGKIGLACLLRSMGVVLPTPLLLRHYHYCHDNALSHTFCLHQDILKLSCSDARISSV YGLCVVITTLGVDSVCILLSYILILNAVLGIASHEERRKALNTCISHICVVLIFFVPVIGVSMVHRFG KHLSPRIΗ11MADIYLLFPPVLNPIVYSIKTKQIRLRILRRFGLRRGH*

FIG. 1 Continued

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B3:72908295-72909287 nucleotide sequence (SEQ ID N0:25)

ATGTTCATTGTTATTCACTCCTTCGTTACTTCTATTTCTCTAACAGCTTTGGAATCTCAGAACGCAAC

AATGCATTTTGTGACTGAGTTTGTCCTCCTGGGTTTTCCTGGTCAAAGGGAGATGCAgaactttttct tctcattaatcCTTGTGGTCTATCTCCTCACTCTGCTGGGGAATGGGGTTATTGTCTATGTAGTGAAA

TGGGACAAGCGGCTTCACACACCCATGTACATCCTCTTGGGAAACTTTGCCTTCCTAGAGATCTGGTA

CATCTCCTCCACTGTCCCAAACATGCTGGTCACCATCCTCTCTGAGACCAAGACCATCTCCTTCACTG

GATGCTTcctccaattttatttctttttctcattgggtACAACAGAGTGTTTCTTCTTATCAGTTATG

GCTTATGACCGGTACCTTGCCATCTGTCGCCCACTACATTATCCTTCCATCATGACTGGGAAGCTCTG

TGTGATCCTGGTCTGCGTTTGCTGGGTGAGTGGATTTCTCTGCTATCCAATCCCCATTGTCCTCATCT

CCCAACTTCCCTTCTGTGGACCTAACATCATTGACCACTTCGTGTGTGACCCAGGCCCATTGTTCGCA

CTGGCCTGCATCCCTGCTCCTTCCACTGAACTTATCTGCTATACCTTCAACTCAGTGATTATCTTTGG

GCCCTTCCTTTCTATCTTGGGATCTTACACTCTGGTACTCAGAGCTGTGCTTCGTATTCCTTCTGGTG

CTGGTCAAACTAAAGCTTTCTCCACATGTGGGTCACACCTAATGGTGGTGTCTCTATTCTATGGAACC

CTTATGGTGATGTATGTAAGCCCAACATCAGGAAATCCAGCAGGAATGCAGAAGATCGTCACTTTGGT

ATACTCAGCAGTGACTCCACTCTTAAACCCCCTTATCTATAGTCTTCGAAATAAAGACATGAAAGATG

CCCTAAAGAAACTCCTAGGATTAAGAAGTAACCCAAACTGA

B3:72908295-72909287 amino acid sequence (SEQ ID N0:55)

MFIVIHSFVTSISLTALESQNATMHFVTEFVLLGFPGQREMQNFFFSLILVVYLLTLLGNGVIVYVVK WDKRLHTPMYILLGNFAFLEIWYISSTVPNMLVTILSETKTISFTGCFLQFYFFFSLGTTECFFLSVM AYDRYLAICRPLHYPSIMTGKLCVILVCVCWVSGFLCYPIPIVLISQLPFCGPN11DHFVCDPGPLFA LACIPAPSTELICYTFNSV11FGPFLSILGSYTLVLRAVLRIPSGAGQTKAFSTCGSHLMVVSLFYGT LMVMYVSPTSGNPAGMQKIVTLVYSAVTPLLNPLIYSLRNKDMKDALKKLLGLRSNPN*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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D1:105486528-105487493 nucleotide sequence (SEQ ID N0:26)

ATGGAGGAGGGTGGTCCCAACCATGGCCAGAGCAACCACACCAATGTGAAGGAATTTGTCTT

CCTAGAACTCACTCACTTCCAGGAGCTGGAATGTTTCTTGTTTGTGGCTTTCCTTGCTGTAT

ATGTAACCACCGTGCTGGGCAATGCCCTCATTGTGCTGACCATCACCTATGAGTCCCACCTT

CACACTCCCATGTACTTTCTGCTGCGGAACAAATCGGTCCTGGACATTGTTTTTTCATCTGT

CACTGTTCCCAAGTTCCTGGTGGATCTGTTATCAGAGAGGAAAACCATCTCCTACAATGGCT

GCATGGCACAGatcttcttcttccattttgctGGTGGGGcagatattttcttcctctccgTG

ATGGCCTATGACAGATACCTTGCAATCGCCAAACCCCTGCATTATGTGACCATTATGAAGAG

AGAGGTGTGGGTGGGCTTGGTGGTGGCTTCCTGGGTGGGCGGTGGTTTGCACTCAATTGTCC

AGATAATTCTGATGCTTCCACTCTCCTTCTGTGGCCCCAACATCCTGGATGCCTTCTACTGT

GATGTGCCCCAAGTAGTTAAGCTGGCTTGCACTGATACCTTTGCTCTGGAACTTCTCATGAT

CTCTAACAATGGGTTGGTGACCCTGCTATGGTTCCTCTTGCTCCTGGGATCCTACACCGTTA

TTCTGGTGATGCTGAGATCTCACTCTGGGGCAGGACGGAACAAGGCCCTGTCCACCTGCACC

TCCCATATCCTCGTGGTGACTCTGCACTTTGTGCCTTGTGTCTACATCTACTGCCGGCCCTT

CACTACACTGCCCATGGACACAGCTGTGTCCATCAATAACACGGTCATTACGCCCATGCTGA

ACCCCATGATTTATACCCTGAGGAACCAGGAGATGAAGTCTGCCATGAAAAGACTACACAGA

AGGCTTGGACCTTCTGAGAGCAGTAAGCTGGGGTGA

D1:105486528-105487493 amino acid sequence (SEQ ID N0:56)

MEEGGPNHGQSNHTNVKEFVFLELTHFQELECFLFVAFLAVYVTTVLGNALIVLTITYESHLHTPMYF LLRNKSVLDIVFSSVTVPKFLVDLLSERKTISYNGCMAQIFFFHFAGGADIFFLSVMAYDRYLAIAKP LHYVTIMKREVWVGLVVASWVGGGLHSIVQ11LMLPLSFCGPNILDAFYCDVPQVVKLACTDTFALEL LMISNNGLVTLLWFLLLLGSYTVILVMLRSHSGAGRNKALSTCTSHILVVTLHFVPCVYIYCRPFTTL PMDTAVSINNTVITPMLNPMIYTLRNQEMKSAMKRLHRRLGPSESSKLG*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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B3:74116955-74117893 nucleotide sequence (SEQ ID N0:27)

ATGGATGCTCTAAATCAAACAAGAGTGACTGAATTTGTCTTCTTGGGACTCACTGATAAGTGGGTGCT

GGAGATACTATTTTTTCTGGCATTCTCCGTCACATATGTATTAACCCTTTTGGGAAACACTCTCATTA

TAGTTACTATAGTCTTTACTCCACGCCTCCATAcccccatgtatttcttcctgagCAATCTGTCCTTT

ATTGACATCTGCCACTCATCTGTCACTGTGCCCAAGATGCTAGAGGGCTTGCTTTTAGAGATAAAGAC

TATTTCCTTTGATAATTGCATTGCACAGCTCTTCTTCCTACATCTGTTTGCTTGTGCTGAGATCTTTC

TGCTGACCATTATGGCTTATGATCGTTATGTAGCCATCTGTGCTCCATTGCACTATTCTAATGTGATG

AACATGAGGGTCTGTGTACAGCTTGTCTTTGCTCTCTGGTTGGGGGCTACTGTTCACTCTCTGGTGCA

GACCTTCTTGACCATTCGTCTACCTTACTGTGGCCCCAACATTATTGATAGCTACTTCTGCGATGTGC

CCCCTGTCATCAAGCTGGCTTGCACAGATACATACCTCACGGGAATGCTAATTGTGTCTAATAGTGGA

ACCATCTCCCTCACCTGTTTCCTGGCTTTGGTCACCTCTTACACGGTCATCCTGGTTTCTCTTAGAAA

ACAGTCAGCTGAAGGGCGCCGGAAAGCCTTGTCTACCTGTTCAGCCCACTTCATGGTTGTAGCCTTCT

TTTTTGGACCATGTATCTTCATCTACACTCGGCCAGACACTAGCTTCTCCATTGACAAGGTGGTATCT

GTCTTCTACACAGTGGTCACTCCTTTGCTGAATCCTCTCATTTACACCTTGAGAAATGAGGAGGTAAA

AAGTGCCATGAAGCATCTCAGACAGAGAGGTTTTTTCATGAAGTCAGGTACATGA

B3:74116955-74117893 amino acid sequence (SEQ ID N0:57)

MDALNQTRVTEFVFLGLTDKWVLEILFFLAFSVTYVLTLLGNTL11VTIVFTPRLHTPMYFFLSNLSF IDICHSSVTVPKMLEGLLLEIKTISFDNCIAQLFFLHLFACAEIFLLTIMAYDRYVAICAPLHYSNVM NMRVCVQLVFALWLGATVHSLVQTFLTIRLPYCGPN11DSYFCDVPPVIKLACTDTYLTGMLIVSNSG TISLTCFLALVTSYTVILVSLRKQSAEGRRKALSTCSAHFMVVAFFFGPCIFIYTRPDTSFSIDKVVS VFYTVVTPLLNPLIYTLRNEEVKSAMKHLRQRGFFMKSGT*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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E3:40237904-40238842 nucleotide sequence (SEQ ID N0:28)

ATGGCAGAGGCCAACAACAGCTTTTCAGAGGGCTGCATCCTGATGGGTATATCTGACCATCCCCAGCT

GGAGATCGTCTTTTTCATAGTCATTCTCTTCTCTTACTCGCTGACCCTAGTTGGGAATTCGACCACCA

TCCTGCTCTCCTGCCTGGATGCCCggctccacacccccatgtacttcttcctcagcAACCTCTCCTCC

CTGGACCTCGCTTTTACTACCAGCTCGGTCCCCCAAATGCTGACCAACTTATGGGGACCAGATAAGAC

TATAAGCTACGCTGGCTGTGTGATCCAGCTCTATGTTTTCCTCTGGCTAGGGGCCACTGAGTGCATCC

TGCTCGTGGTGATGGCATTCGACCGCCATGTGGCAGTTTGCCAGCCCCTGCGCTACACCGTCATCGTG

AGCCCTCGGCTCTGCCGGCTGCTGGCTGCCATTGCATGGCTGGGCGGCTTGAGCAACTCCATGATCCA

GTCAACGTTCACTCTCCAGCTCCCATTGTGTGGGCACCGGAGGGTGGACAACTTCCTGTGTGAGGTGC

CTGCCATGATCAAACTGGCCTGTGGAGACACAAGTCTCAACGAGGCCGTGCTCAATGGTGTCTGCACC

TTCTTCACTGCCGTCCCGCTGAGCATCATCCTGATCTCCTACTGCTCCATAGCTCGGGCAGTGCTGAA

GATCCGCTCagctgagggacagagaaaggccTTTAATACTTGCCTTTCCCATCTGGTGGTGGTGCTCC

TCTTCTATGGGTCAGCTATCTACGGGTACCTCCTTCCGGCTAAGACCAGCCACCAGGGCCAAGGCAAA

TTCATTTCCCTCTTCTACTCTGTGGTCACGCCAATGGTGAACCCTCTCATCTACACTCTGAGAAACAA

GGAGGTAAAGGCGGCACTGAGGAGGCTccggggaaagggaagagaattcGGCTGA

E3:40237904-40238842 amino acid sequence (SEQ ID N0:58)

MAEANNSFSEGCILMGISDHPQLEIVFFIVILFSYSLTLVGNSTTILLSCLDARLHTPMYFFLSNLSS LDLAFTTSSVPQMLTNLWGPDKTISYAGCVIQLYVFLWLGATECILLVVMAFDRHVAVCQPLRYTVIV SPRLCRLLAAIAWLGGLSNSMIQSTFTLQLPLCGHRRVDNFLCEVPAMIKLACGDTSLNEAVLNGVCT FFTAVPLS11LISYCSIARAVLKIRSAEGQRKAFNTCLSHLVVVLLFYGSAIYGYLLPAKTSHQGQGK FISLFYSVVTPMVNPLIYTLRNKEVKAALRRLRGKGREFG*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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D1:105462554-105463512 nucleotide sequence (SEQ ID N0:29)

ATGAGAAGCATGTCCACAGCTAAGGCCTGGAATAGCTCTTCAGTAACCATGTTCATCTTCCTGGGATT

TGCAGACCATCCAGAACTCCAGACCCTTCTCTTTGTGACCTTCCTGGGTATCTATCTTGTGACACTGG

CCTGGAACCTGGCCCTCATCTTTTTGATCAGAGGTGACCCCCGTCTGCAcacacccatgtacttcttc ctcagcAACTTGTCTTTCATCGACATCTGCTACTCTTCTACAGTGGCCCCCAAGATGCTCACTGATTT

CTTCTGGGAGCAAAAGACCATATCATTCTTGGGCTGTGctgctcagttttttttctttgtcagtatGG

GTCTCACTGAGTGCTTCCTCCTGACTGCCATGGCATACGACAGATACGCAGCCATCTCCAATCCCCTG

CTGTACACAGCCATCATGTCCCAAGGCCTCTGCACACGCATGGTGCTTGGGGCATATGTTGGTGGCTT

CCTGAGCTCCCTGATCCAGGCCAGCTCCATATTTCAGCTTCACTTCTGCGGACCCAACATTATCAATC

ATTTCTTCTGTGACCTCCCTCCAGTACTGGCACTTTCTTGCTCTGACACCTTTCCTAGTCAAGTGGTG

AATTTTCTCGTGGTAGTCACTATTGGGGGGACATCATTCCTCATCCTCATCATCTCCTACAGTTACAT

AGGAACTGCTGTCTTGAAAATCCGTTCAGTGGAAGGCCGAAAGAAAGCCTTCAGCACATGTGCCTCAC

ACTTGATGGTGGTGACTCTGTTGTTTGGGACGGCCCTTTTCATGTACCTGAGACCCAGCTCCAGCTAC

TCGCTTGGCAGGGACAAGGTAGTGTCTGTGTTCTATTCACTGGTGATCCCCATGCTGAACCCTCTTAT

TTACAgtttgaggaacagagagatcaaAGATGCCCTATGGAAGGTGTTGGAGAAGAAGAAACTGTTTT

CCTAG

D1:105462554-105463512 amino acid sequence (SEQ ID N0:59)

MRSMSTAKAWNSSSVTMFIFLGFADHPELQTLLFVTFLGIYLVTLAWNLALIFLIRGDPRLHTPMYFF LSNLSFIDICYSSTVAPKMLTDFFWEQKTISFLGCAAQFFFFVSMGLTECFLLTAMAYDRYAAISNPL LYTAIMSQGLCTRMVLGAYVGGFLSSLIQASSIFQLHFCGPN11NHFFCDLPPVLALSCSDTFPSQVV NFLVVVTIGGTSFLIL11SYSYIGTAVLKIRSVEGRKKAFSTCASHLMVVTLLFGTALFMYLRPSSSY SLGRDKVVSVFYSLVIPMLNPLIYSLRNREIKDALWKVLEKKKLFS*

FIG. 1 Continued

SUBSTITUTE SHEET (RULE 26)

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D1:21266824-21267768 nucleotide sequence (SEQ ID N0:30)

ATGCCTTTAATGAGAATGGCAGCTGAGAACTCCTCTGTGACAGAATTTATCCTTGCAGGCTTAACCAA

CCAGCCCGGACTTCGGATGCccctcttcttcctgtttctogGTTTCTATGTGGTCACTGTGATGGGGA

ACCTGGGTCTGATAACCCTGATTGGGCTGAATTCTCACCtgcacacccccatgtacttcttcctcttc

AACTTGTCCTTCATAGATTTTTGCTATTCCACTGTTATCACTCCCAAGATGCTGATGAGTTTTGTCTC

AAAGAACACCATCGCCTACGCAGGGTGTATGACTcagctcttcttttttcttttctttgttgtctCTG

AGTCCTTCATCCTGTCAGCAATGGCATATGACCGCTACACCGCCATCTGTAACCCACTGGTGTACACA

GCCACCATGTCTCCTCAGGTCTGCTCGCTTCTTCTGTTGGGTGTCTATGTGATGGGGTTTGCTGGGGC

CATGGCCCACACGACATGCATGGTGAGGCTGACCTTCTGTGCCAACAATCTGGTTGACCACTACATGT

GTGACATCCTTCCCCTTCTTGAGCGCTCTTGCACCAGCACCTATGTAAATGAGCTGGTAGTTTTCGTT

GTCGTGGGCATTGATATTGGCGTGCCCACAGTTACCATCTTCATTTCTTATGccctcatcctcaccag cattcTCCATATTCGTTCCACTGAGGGCAGGTCCAAAGCCTTCAGCACATGCAGCTCTCACATAAttg ctgtttctcttttctttgggtCAGGGGCATTTATGTACCTCAAACCATCCTCTCTTTTACCTATGAAT

CAGGGGAAAGTGTCCTCCTTGTTCTATACCACCGTTGTGCCCATGCTCAACCCGCTAATCTATAGCTT

AAGAAATAAAGATGTCAAAGTTGCTCTGAAGAAATCATTGAGCAAAAAGACATTCTCTTGA

D1:21266824-21267768 amino acid sequence (SEQ ID N0:60)

MPLMRMAAENSSVTEFILAGLTNQPGLRMPLFFLFLGFYVVTVMGNLGLITLIGLNSHLHTPMYFFLF NLSFIDFCYSTVITPKMLMSFVSKNTIAYAGCMTQLFFFLFFVVSESFILSAMAYDRYTAICNPLVYT ATMSPQVCSLLLLGVYVMGFAGAMAHTTCMVRLTFCANNLVDHYMCDILPLLERSCTSTYVNELVVFV VVGIDIGVPTVTIFISYALILTSILHIRSTEGRSKAFSTCSSH11AVSLFFGSGAFMYLKPSSLLPMN QGKVSSLFYTTVVPMLNPLIYSLRNKDVKVALKKSLSKKTFS*

FIG. 1 Continued

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SEQ ID NOS 41, 51 and 31, respectively, in order of appearance

1 10 20 30 40 50 I , 1 . I , I , I . 1 CafaOR9.2.9 CatG1 HsOR17.1.11 MQSKFGANSTAITEFILLGLVOTPGLQPVVFVVFLFAYLVTVGGNLSILA MKSKFEYNRTAITEFILLGLVETPDLRPVVFVVFLLSYLLTVGGNLSILA MQPESGANGTVIAEFILLGLLEAPGLQPVVFVLFLFAYLVTVRGNLSILA 60 70 _h ·β^θι^{θ 1}?° CafaOR9.2.9 CatG1 HsOR17.1.11 AILVEPKLHTPMYFFLGNLSVLDVGCITVTVPSMLARLLSHKRTVPYRAC AILVEPKLHTPMYFFLGNLSVLDIGCITVTIPSMLARLLSHKRTVPYGAC AVLVEPKLHTPMYFFLGNLSVLDVGCISVTVPSMLSRLLSRKRAVPCGAC 110 120 130 140 150 i i CafaOR9.2.9 CatG1 HsOR17.1.11 LTQLFFFHLLVGVDCFLLTAMAYDRFLAICRPLTYSTQMSQTVQRILVVV LTQLFFFHLLVGVDCFLLTAMAYDRFLAICQPLTYSTRMSQTVQRILVAV LTQLFFFHLFVGVDCFLLTAMAYDRFLAICRPLTYSTRMSQTVQRMLVAA 160 170 180 190 200 1 1 1 , 1 1 CafaOR9.2.9 CatG1 HsOR17.1.11 SWALAFTNALTHTVAIATLNFCGPNVINHFYCDLPQLFQLSCSSTQLNEL SWALAFTNALTHTVAISTLNFCGPNVINHFYCDLPQLFQLSCSSTQLNEL SWACAFTNALTHTVAMSTLNFCGPNVINHFYCDLPQLFQLSCSSTQLNEL 210 220 230 240 250 l , I , I , I , 1 CafaOR9.2.9 CatG1 HsOR17.1.11 LLFAVGFIMAGTPLALIITSYAHVAAAVLRIRSAEGRKKAFSTCGSHLTV LLFAVGFIMAGTPLALIVTSYAHVTAAVLRIRSAEGRKKAFSTCGSHLTV LLFAVGFIMAGTPMALIVISYIHVAAAVLRIRSVEGRKKAFSTCGSHLTV B·²?⁰· ²⁷⁰ ·?^θ· ²?° ³?° CafaOR9.2.9 CatG1 HsOR17.1.11 VAIFYGSGIFNYMRLGTAKHSDKDKGVGVFNTVINPMLNPIIYSLRNLDV VAIFYGSGIFNYMRLGSAKLSDKDKAFGIFNTVINPMLNPIIYSLRNPDV VAIFYGSGIFNYMRLGSTKLSDKDKAVGIFNTVINPMLNPIIYSFRNPDV 310 320 330 340 350 , I . I , I , I . I CafaOR9.2.9 CatG1 HsOR17.1.11 QGALWRVLRGRQSLA QGALWRVLMGRRPLA QSAIWRMLTGRRSLA

FIG. 2A

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FIG. 2B

FIG. 2C

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

33/97

FIG. 2D

FIG. 2E

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

34/97

SEQ ID NOS 52, 32 and 42, respectively, in order of appearance

1 10 20 30 40 50 I , 1 . I , I , I . 1 CatG2 HsOR1.4.8 CafaOR38.1.21 MGNWSRGHIAEFVLVGFPTSPPLQCLLFVLFLAIYLLTLLENALIVSTV MRNLSGGHVEEFVLVGFPTTPPLQLLLFVLFFAIYLLTLLENALIVFTI MMGNLSGGHIADFILVGFPTSPPLQLLLFVLFFAIYLLTLLENALIVSTI 60 70 80 90 100 I I , I CatG2 HsOR1.4.8 CafaOR38.1.21 WLTPSLHRPMYFFLGHLSFLELWYINVTVPRLLGAFLTQERRVSYVGCMT WLAPSLHRPMYFFLGHLSFLELWYINVTIPRLLAAFLTQDGRVSYVGCMT WLTPSLHRPMYFFLGHLSFLELWYINVTVPRLLGAFLTQDRRVSYVGCMT 110 120 130 140 150 ·ι CatG2 HsOR1.4.8 CafaOR38.1.21 QLYFFIALACTECVLLAVMAYDRYLAICEPLRYPSLMPSSLAIRLAASSW QLYFFIALACTECVLLAVMAYDRYLAICGPLLYPSLMPSSLATRLAAASW QLYFFIALACTECVLLAVMAYDRYLAICEPLRYPSLMPSSLAIRLAASSW 160 170 180 190 200 l· CatG2 HsOR1.4.8 CafaOR38.1.21 GSGFLSSMMKLLFISRLSYCGPNVINHFFCDISPLLNLTCSDKEQAELVD GSGFFSSMMKLLFISQLSYCGPNIINHFFCDISPLLNLTCSDKEQAELVD GGGFFSSMMKLLFISRLSYCGPNIINHFFCDISPLLNLTCSDKEQAELVD 210 220 230 240 250 , 1 1 1 1 1 CatG2 HsOR1.4.8 CafaOR38.1.21 FLLALVMILLPLLAVVSSYAAIMAAILRIPTAQGRRKAFSTCASHLAVVV FLLALVMILLPLLAVVSSYTAIIAAILRIPTSRGRHKAFSTCAAHLAVVV FLLALVMILLPLLAVVSSYAAIIATILRIPTAQGRRKAFSTCASHLAVVV 260 270 280 290 300 , 1 , 1 CatG2 HsOR1.4.8 CafaOR38.1.21 IYYSSTLFTYARPQAMYTFNHNKVISVLYTVIVPFLOPAIYCLRNKEVKD IYYSSTLFTYARPRAMYTFNHNKIISVLYT11VPFFOPAIYCLRNKEVKE IYYSSTLFTYARPRAMYTFNHNKIISVLYTVIVPFLOPAIYCLRNKEVKD 310 320 330 340 350 , I . I , I , I . I CatG2 HsOR1.4.8 CafaOR38.1.21 ALRKSVLGRCHYPRDVPD AFRKTVMGRCHYPRDVQD ALRKLVLGRCHYPSDVPD

FIG. 3A

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

35/97

FIG. 3B

X

FIG. 3C

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

36/97

LYS273

FIG. 3D

FIG. 3E

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

37/97

SEQ ID NOS 43, 53 and 33, respectively, in order of appearance i

L

L

L

L

CafaOR21.2.15

CatG3

HsOR11.3.14

MVDPNGNESSATYFILIGLPGLEEAQFWLAFPLCSLYFIAVLGNLT11Y MVDTNGSESSATYFILIGLPGLEKAQFWLAFPLCSLYLIAVLGNLTVIC lMVDPNGNESSATYFILIGLPGLEEAQFWLAFPLCSLYLIAVLGNLT11Y i

L

L

100

CafaOR21.2.15

CatG3

HsOR11.3.14

IVRTEHSLHEPMYVFLCMLSGLDILISTSSMPKMMAIFWFNSTTIQFDAC IVRTEHRLHEPMYIFLCMLSGLDILISTSSMPRMMAIFWFNSTTIQFDAC IVRTEHSLHEPMYIFLCMLSGIDILISTSSMPKMLAIFWFNSTTIQFDAC

110

120

I

130

I

140

I

150 i

CafaOR21.2.15

CatG3

HsOR11.3.14

LLQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVMKIGMA

LLQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVTKIGVA

LLQMFAIHSLSGMESTVLLAMAFDRYVAICHPLRHATVLTLPRVTKIGVA

160

170

I

180 i

190

I

200

L_i_

CafaOR21.2.15

CatG3

HsOR11.3.14

AVVRGTALMAPLPVFIKRLPFCHSNILSHSYCLHQDVMKLACADIRVNII

AVVRGTSLMAPLPIFIKRLPFCRSNILSHSYCLHQDVMKLACADIRVNII

AVVRGAALMAPLPVFIKQLPFCRSNILSHSYCLHQDVMKLACDDIRVNVV

210 ”lL_

220

I

230

I

240

I

250

L

CafaOR21.2.15

CatG3

HsOR11.3.14

YGLIVIISAIGLDSLLISLSYLLILKTVLGLTREAQAKAFGTCVSHVCAV

YGLIVIISAIGLDSLLISLSYLLILKTVLGLTREAQAKAFGTCVSHVCAV

YGLIVIISAIGLDSLLISFSYLLILKTVLGLTREAQAKAFGTCVSHVCAV

260

270

I

290

I

300 i

CafaOR21.2J5

CatG3

HsOR11.3.14

FIFYVPFIGLSMVHRFGKRHDSFLPIIMANTYLLVPPVLNPIVYGVKTKE

FIFYVPFIGLSMVHRFGKRHDSLLPIIMANTYLLVPPVLNPIVYGVKTKE

FIFYVPFIGLSMVHRFSKRRDSPLPVILANIYLLVPPVLNPIVYGVKTKE

310 320 , I . I 330 I 340 I 350 I CafaOR21.2.15 IWQRILRLFHVTNHTSDL CatG3 IRQRILRLFHVTTHTSDP HsOR11.3.14 IRQRILRLFHVATHASEP

FIG. 4A

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

FIG. 4B

FIG. 4C

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

39/97

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

40/97

SEQ ID NOS 34, 44 and 54 respectively, in order of appearance

1 10 20 30 40 50 1 1 , 1 1 1 HsOR11.3.40 CafaOR21.2.43 CatG4 -----MGDWNNSDAVEPIFILRGFPGLEYVHSWLSILFCLAYLVAFMGNV MPRVTMVVWNNNNTLEPIFILKGFPGLECVHSWFSIPFCLAYLVAFIGNV MPRFTMVVWNNNNTMEPIFILRGFHGLECVHSWISVPFCLAYLVAFIGNV 60 70 80 90 100 I . HsOR11.3.40 CafaOR21.2.43 CatG4 TILSVIWIESSLHQPMYYFISI LAVNDLGMSLSTLPTMLAVLWLDAPEIQ TILSVIWIESSLHQPMYYFISI LALTDLGMSMSTLPTMLAVLWLDAREIQ TILSVIWIESSLHQPMYYFLSILALTDLGMSMSTLPTMLAVLWLDAREIQ 110 120 130 140 150 . i , i , i , i HsOR11.3.40 CafaOR21.2.43 CatG4 ASACYAQLFFIIHTFTFLESSVLLAMAFDRFVAICHPLHYPTILTNSVIGK ASACYAQLFFIIHTFTFLESSVLLAMAFDRFVAICRPLHYTTILNNSVIGK ASACYAQLFFIIHTFTFLESSVLLAMAFDRFVAICRPLHYTTILNNSVIGK 160 170 180 190 200 HsOR11.3.40 CafaOR21.2.43 CatG4 IGLACLLRSLGVVLPTPLLLRHYHYCHGNALSHAFCLHQDVLRLSCTDAR IGLACLLRSMGVVLPTPLLLRHYHYCHVNALSHAFCLHQDVLKLSCSDAR IGLACLLRSMGVVLPTPLLLRHYHYCHDNALSHTFCLHQDILKLSCSDAR 210 220 230 240 250 , HsOR11.3.40 CafaOR21.2.43 CatG4 TNSIYGLCVVIATLGVDSIFILLSYVLILNTVLDIASREEQLKALNTCVS ISSVYGLCVVITTLGMDSVFILLSYVLILNAVLGIASHEERLKALNTCVS ISSVYGLCVVITTLGVDSVCILLSYILILNAVLGIASHEERRKALNTCIS 260 270 280 290 300 HsOR11.3.40 CafaOR21.2.43 CatG4 HICVVLIFFVPVIGVSMVHRFGKHLSPIVHILMADIYLLLPPVLNPIVYS HICVVLIFFVPVIGVSMVHRFGKHLSPIVHIIMADIYLLFPPVLNPIVYS HICVVLIFFVPVIGVSMVHRFGKHLSPRIHIIMADIYLLFPPVLNPIVYS 310 320 330 340 350 , I . I , I , I . I HsOR11.3.40 CafaOR21.2.43 CatG4 VRTKQIRLGILHKFVLRRRP VRTKQIRIRIFHKLRLGRRL IKTKQIRLRILRRFGLRRGH

FIG. 5A

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

41/97

FIG. 5C

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

42/97

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

43/97

SEQ ID NOS 35, 45 and 55, respectively, in order of appearance

1 10 20 30 40 50 I , 1 . I , I , I . 1 HsOR14.1.27 Cafa0R15.2.20 CatGrS MFFIIHSLVTSVFLTALGPQNRTMHFVTEFVLLGFHGQREMQSCFFSFIL MLIIIHSLVISASLTALESQNTTMRFVSEFVLLGFPGQREMQNFFFSFIL MFIVIHSFVTSISLTALESQNATMHFVTEFVLLGFPGQREMQNFFFSLIL 60 70 80 90 100 , 1 . I , I , I . 1 HsOR14.1.27 Cafa0R15.2.20 CatGrS VLYLLTLLGNGAIVCAVKLDRRLHTPMYILLGNFAFLEIWYISSTVPNML VIYLLTLLGNGIIVCIVKWDKQLHTPMYIFLGNFAFLEIWYTSSTVPSML VVYLLTLLGNGVIVYVVKWDKRLHTPMYILLGNFAFLEIWYISSTVPNML 110 120 130 140 150 , 1 , I , I , I , 1 HsOR14.1.27 Cafa0R15.2.20 CatGr5 VNILSEIKTISFSGCFLQFYFFFSLGTTECFFLSVMAYDRYLAICRPLHY VNILSEIKTISFTGCFLQFYFFFSLGTTECFFLSVMAYDRYLAICRPLHY VTILSETKTISFTGCFLQFYFFFSLGTTECFFLSVMAYDRYLAICRPLHY 160 170 180 190 200 , 1 . I , I , I . 1 HsOR14.1.27 Cafa0R15.2.20 CatGr5 PSIMTGKFC11LVCVCWVGGFLCYPVPIVLISQLPFCGPNIIDHLVCDPG PSIMTGKLCVALVCVCWVSGFLCYPVPIVLISQLPFCGPNIIDHFVCDPG PSIMTGKLCVILVCVCWVSGFLCYPI PIVLISQLPFCGPNIIDHFVCDPG 210 220 230 240 250 , 1 , I , I , I , 1 HsOR14.1.27 Cafa0R15.2.20 CatGrS PLFALACISAPSTELICYTFNSMIIFGPFLSILGSYTLVIRAVLCIPSGA PLFALACIPAPSTELLCYTFNSLIIFGPFLFILGSYTLVLRAVLRIPSGA PLFALACIPAPSTELICYTFNSVIIFGPFLSILGSYTLVLRAVLRIPSGA 260 270 280 290 300 , 1.1,1,1.1 HsOR14.1.27 Cafa0R15.2.20 CatGrS GRTKAFSTCGSHLMVVSLFYGTLMVMYVSPTSGNPAGMQKIITLVYTAMT GRTKAFSTCGSHLMVVSLFYGTLMVMYVSPTSGNPTGMQKIITLVYTAVT GQTKAFSTCGSHLMVVSLFYGTLMVMYVSPTSGNPAGMQKIVTLVYTAVT 310 320 330 340 350 , I , I , I , I , I HsOR14.1.27 Cafa0R15.2.20 CatGr5 PFLNPLIYSLRNKDMKDALKRVLGLTVSQN PLLNPLIYSLRNKDMKDALKKVLGLRSNQN PLLNPLIYSLRNKDMKDALKKLLGLRSNPN

FIG. 6A

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

44/97

FIG. 6B

OH

FIG. 6C

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

45/97

GLN118

FIG. 6D

FIG. 6E

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

46/97

SEQ ID NOS 36, 56 and 46, respectively, in order of appearance

1 10 20 30 40 50 I , 1 . I , I , I . 1 HsOR11.13.7 CatGr6 CafaOR18.3.11 -------MDQINHTNVKEFFFLELTRSRELEFFLFVVFFAVYVATVLGNA MEEGGPNHGQSNHTNVKEFVFLELTHFQELECFLFVAFLAVYVTTVLGNA -------MGQSNHTNVKEFVFLKLTHFHELELFLFVVFLAVYVATVLGNV 60 70 80 90 100 ,1 , HsOR11.13.7 CatGr6 CafaOR18.3.11 LIVVTITCESRLHTPMYFLLRNKSVLDIVFSSITVPKFLVDLLSDRKTIS LIVLTITYESHLHTPMYFLLRNKSVLDIVFSSVTVPKFLVDLLSERKTIS LIVVTITCESHLHSPMYFLLRNKSVLDIVFSSVTVPKFLVDLLSERKTIS 110 120 130 140 150 I , I , I , 1 HsORl 1.13.7 CatGr6 CafaOR18.3.11 YNGCMAQIFFFHFAGGADIFFLSVMAYDRYLAIAKPLHYVTMMRKEVWVA YNGCMAQIFFFHFAGGADIFFLSVMAYDRYLAIAKPLHYVTIMKREVWVG YNGCMAQIFFFHFAGGADIFFLSVMAYDRYLAIAKPLHYVTIMRRETWVG 160 170 180 190 200 1 IM 1 HsORl 1.13.7 CatGr6 CafaOR18.3.11 LVVASWVSGGLHS11QVILMLPFPFCGPNTLDAFYCYVLQVVKLACTDTF LVVASWVGGGLHSIVQ11LMLPLSFCGPNILDAFYCDVPQVVKLACTDTF LVVASWVGGGLHSIVQVTLMLPLPFCGPNILDAFYCDVPQVIKLACTNTF 210 220 230 240 250 , HsORl 1.13.7 CatGr6 CafaOR18.3.11 ALELFMISNNGLVTLLWFLLLLGSYTVILVMLRSHSGEGRNKALSTCTSH ALELLMISNNGLVTLLWFLLLLGSYTVILVMLRSHSGAGRNKALSTCTSH ALELLMISNNGLVTLLWFLLLLGSYTVILVMLRSHSGEGRNKALSTCTSH 260 270 280 290 300 HsOR11.13.7 CatGr6 CafaOR18.3.11 MLVVTLHFVPCVYIYCRPFMTLPMDTTISINNTviTPMLNPIIYSLRNQE ILVVTLHFVPCVYIYCRPFTTLPMDTAVSINNTVITPMLNPMIYTLRNQE IFVVTLHFVPCVYIYCRPFITLPMDTVVSINNTVITPMLNPMIYTLRNQE 310 320 330 340 350 , I . I , I , I . I HsOR11.13.7 CatGr6 CafaOR18.3.11 MKSAMQRLQRRLGPSESRKWG MKSAMKRLHRRLGPSESSKWG MKSAMKRLQRRLGPSESS--

FIG. 7A

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

47/97

FIG. 7C

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

48/97

FIG. 7E

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

49/97

SEQ ID NOS 47, 37 and 57, respectively, in order of appearance

1 10 20 30 40 50 I , 1 1 , 1· , 1 1 CafaORl 5.3.1 HsORI 4.2.5 CatG7 MEAPNQTRVTEFVFLGLTDNWALGTLLFVAFSLAYVLTLLGNTLIIVTTA MDSLNQTRVTEFVFLGLTDNRVLEMLFFMAFSAIYMLTLSGNILIIIATV MDALNQTRVTEFVFLGLTDKWVLEILFFLAFSVTYVLTLLGNTLIIVTIV 60 70 80 90 100 CafaORl 5.3.1 HsORI 4.2.5 CatG7 LTRRLHTPMYFFLSNLSFIDTCHSSVTVPKMLEGLLRERKTISFDDCIAQ FTPSLHTPMYFFLSNLSFIDICHSSVTVPKMLEGLLLERKTISFDNCITQ FTPRLHTPMYFFLSNLSFIDICHSSVTVPKMLEGLLLEIKTISFDNCIAQ 110 120 130 140 150 1 1 1 1 1 CafaORl 5.3.1 HsOR14.2.5 CatG7 LFFLHLFACAEILLLTVMAYDRYVAICAPLRYPNVMSIRVCVQLVLALWW LFFLHLFACAEIFLL11MAYDRYVAICTPLHYPNVMNMRVCIQLVFALWL LFFLHLFACAEIFLLTIMAYDRYVAICAPLHYSNVMNMRVCVQLVFALWL 160 170 180 190 200 1 . I , I , I . 1 CafaORl 5.3.1 HsORI 4.2.5 CatG7 GGTVHSLVQTLLTIRLPYCGPNVIDSYFCDVPPVIKLACTDTYLTGVLIV GGTVHSLGQTFLTIRLPYCGPNIIDSYFCDVPLVIKLACTDTYLTGILIV GATVHSLVQTFLTIRLPYCGPNIIDSYFCDVPPVIKLACTDTYLTGMLIV 210 220 230 240 250 , 1 , I , I , I , 1 CafaORl 5.3.1 HsOR14.2.5 CatG7 SNSGTISLTCFLALVTSYTIILVSLRKQSAEGRRKALSTCSAHFMVVAFF TNSGTISLSCFLAVVTSYMVILVSLRKHSAEGRRKALSTCSAHFMVVALF SNSGTISLTCFLALVTSYTVILVSLRKQSAEGRRKALSTCSAHFMVVAFF 260 270 280 290 300 CafaORl 5.3.1 HsORI 4.2.5 CatG7 FGPciFIYTRPDTSFSIDKVVSVFYTVVTPLLNPLIYTLRNEEVKSAIKH FGPCIFIYTRPDTSFSIDKVVSVFYTVVTPLLNPFIYTLRNEEVKSAMKQ FGPCIFIYTRPDTSFSIDKVVSVFYTVVTPLLNPLIYTLRNEEVKSAMKH 310 320 330 340 350 , I . I , I , I . I CafaORl 5.3.1 HsOR14.2.5 CatG7 LRQKQVFS----- LRQRQVFFTKSYT LRQRG EFM K S G T-

FIG. 8A

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

50/97

FIG. 8B < 'Vx

FIG. 8C

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

51/97

LYS269

FIG. 8E

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

52/97

SEQ ID NOS

38, 58 and 48, respectively, in order of appearance i

i l

l

L

HsOR16.1.3

CatG8

CafaOR6.3.1

MDGVNDSSLQGFVLMGISDHPQLEMIFFIAILFSYLLTLLGNSTIILLSR

MAEANNSFSEGCILMGISDHPQLEIVFFIVILFSYSLTLVGNSTTILLSC

MPEANDSFLEGFILMGISDHPQLEIIFFMVILFSYLLTLLGNSTIILLSW i

i

100

HsOR16.1.3

CatG8

CafaOR6.3.1

HsOR16.1.3

CatG8

CafaOR6.3.1

HsOR16.1.3

CatG8

CafaOR6.3.1

HsOR16.1.3

CatG8

CafaOR6.3.1

HsOR16.1.3

CatG8

CafaOR6.3.1

HsOR16.1.3

CatG8

CafaOR6.3.1

LEARLHTPMYFFLSNLSSLDLAFATSSVPQMLINLWGPGKTISYGGCITQ LDARLHTPMYFFLSNLSSLDLAFTTSSVPQMLTNLWGPDKTISYAGCVIQ LDARLHTPMYFFLSNLSTLDLAFTTSSVPQMLINLWGPDKTISYGGCVTQ

110

I

120

I

130

I

140

I

150 i

LYVFLWLGATECILLVVMAFDRYVAVCRPLRYTAIMNPQLCWLLAVI AWL LYVFLWLGATECILLVVMAFDRHVAVCQPLRYTVIVSPRLCRLLAAI AWL LYVFLWLGATECILLVVMAFDRYVAVCRPLHYTTIMNPRLCWLLAAI AWL

170

I

180

190

I

200

GGLGNSVIQSTFTLQLPLCGHRRVEGFLCEVPAMIKLACGDTSLNQAVLN

GGLSNSMIQSTFTLQLPLCGHRRVDNFLCEVPAMIKLACGDTSLNEAVLN

GGLSNSVIQSTFTLQLPLCGHRRVDNFLCEVPAMIKLACGDTSLNEVVLN

210

I

220

I

230

I

240

I

250 i

GVCTFFTAVPLSIIVISYCLIAQAVLKIRSAEGRRKAFNTCLSHLLVVFL

GVCTFFTAVPLSIILISYCSIARAVLKIRSAEGQRKAFNTCLSHLVVVLL

GVCTFFTAVPLSVILISYCYIAQAVLKIHSVEGQRKAFNTCLSHLVVVLL

260

270

L

280

IL_

290

I

300 i

FYGSASYGYLLPAKNSKQDQGKFISLFYSLVTPMVNPLIYTLRNMEVKGA

FYGSAIYGYLLPAKTSHQGQGKFISLFYSVVTPMVNPLIYTLRNKEVKAA

FYGSAIYGYLLPAKTSNQDQGKFISLFYSVVTPTVNPLIYTLRNREVKGA

310 , I 320 I 330 I 340 I 350 I LRRLLGKGREVG LRRLRGKGREFG LRRLLGKGRSLG

FIG. 9A

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

53/97

FIG. 9B

FIG. 9C

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

54/97 fig. 9D

PHE206

FIG. 9E

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

55/97

SEQ ID NOS 49, 59 and

39, respectively, in order of appearance

1 10 20 30 40 50 I , 1 1 1 , 1 1 CafaOR18.3.12 CatG9 HsOR11.13.6 MSTVKAWNSSSVTMFILLGFADHPELQTLLFVTFLSIYLVTLAWNLA MRSMSTAKAWNSSSVTMFIFLGFADHPELQTLLFVTFLGIYLVTLAWNLA ---MS ITKAWNSSSVTMFILLGFTDHPELQALLFVTFLGIYLTTLAWNLA 60 70 80 90 100 I I CafaOR18.3.12 CatG9 HsOR11.13.6 LIFLIRSDPHLHTPMYFFLSNLSFIDICYSSTVAPKMLTDFFQEQKTISF LIFLIRGDPRLHTPMYFFLSNLSFIDICYSSTVAPKMLTDFFWEQKTISF LIFLIRGDTHLHTPMYFFLSNLSFIDICYSSAVAPNMLTDFFWEQKTISF 110 120 130 140 150 CafaOR18.3.12 CatG9 HsOR11.13.6 LGCAAQFFFFVSMGLTECFLLTAMAYDRYAAISNPLLYTAIMSQGLCTRM LGCAAQFFFFVSMGLTECFLLTAMAYDRYAAISNPLLYTAIMSQGLCTRM VGCAAQFFFFVGMGLSECLLLTAMAYDRYAAISSPLLYPTIMTQGLCTRM 160 170 180 190 200 CafaOR18.3.12 CatG9 HsOR11.13.6 VLGAYVGGFLSSLIQAISIFQLHFCGPNIINHFFCDLPPVLALSCSDTFP VLGAYVGGFLSSLIQASSIFQLHFCGPNIINHFFCDLPPVLALSCSDTFP VVGAYVGGFLSSLIQASSIFRLHFCGPNIINHFFCDLPPVLALSCSDTFL 210 220 230 240 250 CafaOR18.3.12 CatG9 HsOR11.13.6 SQVVNFLIVITVGGTSFLILLISYSYIGAAVLKIRSVEGRRKAFNTCASH SQVVNFLVVVTIGGTSFLILIISYSYIGTAVLKIRSVEGRKKAFSTCASH SQVVNFLVVVTVGGTSFLQLLISYGYIVSAVLKIPSAEGRWKACNTCASH 260 270 280 290 300 CafaOR18.3.12 CatG9 HsOR11.13.6 LMVVTLLFGTALFMYLRPSSSYSLARDKVVSVFYSLVIPMLNPLIYSLRN LMVVTLLFGTALFMYLRPSSSYSLGRDKVVSVFYSLVIPMLNPLIYSLRN LMVVTLLFGTALFVYLRPSSSYLLGRDKVVSVFYSLVIPMLNPLIYSLRN 310 320 330 340 350 , I . I , I , I . I CafaOR18.3.12 CatG9 HsOR11.13.6 RDIKDALWKALEKKKVFFLDHD REIKDALWKVLEKKKLFS---- KEIKDALWKVLERKKVFS----

FIG. 10A

SUBSTITUTE SHEET (RULE 26) wo 2018/064636

56/97

PCT/US2017/054620

FIG. 10C

FIG. 10C

SUBSTITUTE SHEET (RULE

26)

WO 2018/064636

PCT/US2017/054620

57/97

FIG. 10E

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

58/97

SEQ ID NOS 60, 3,809, 50 and 40, respectively, in order of appearance

1 10 20 30 40 50 I , 1 , I . I , I , 1 CatGIO Olfr145 CafaOR5.2.5 HsOR11.18.36 MPLMRMAAENS-SVTEFILAGLTNQPGLRMPLFFLFLGFYVVTVMGNLGL -----MATENA-SVPEFILAGLTDQPGLRMPLFFLFLGFYMVTMVGNLGL MPLMRMAAENSSVTEFILSGLTNQPGLQIPLFFLFLGFYVVTVVGNLGL -----MAAENSSFVTQFILAGLTDQPGVQIPLFFLFLGFYVVTVVGNLGL 60 70 80 90 100 CatGIO 0lfr145 CafaOR5.2.5 HsOR11.18.36 ITLIGLNSHLHTPMYFFLFNLSFIDFOYSTVITPKMLMSFVS-KNTIAYA ITLIGLNSHLHTPMYFFLFNLSLIDFOYSTVITPKMLMSFVSKKNIISYS ITLIGLNSHLHTPMYFFLFNLSFIDFOYSTVITPKMLMNFVLRKNVISYA ITLIRLNSHLHTPMYFFLYNLSFIDFOYSSVITPKMLMSFVLKKNSISYA 110 120 130 140 150 I CatGIO 0lfr145 CafaOR5.2.5 HsOR11.18.36 GCMTQLFFFLFFVVSEEFILSAMAYDRYTAICNPLVYTATMSPQVCSLLL GCMTQLFFFLFFVVSEEFILSAMAYDRYVAICNPLMYTVTMSPQVCLLLL GCMTQLFFFLFFVVSEEFILSAMAYDRYAAICNPLVYTATMSPQVCFLLL GCMTQLFFFLFFVVSEEFILSAMAYDRYVAICNPLLYMVTMSPQVCFLLL 160 170 180 190 200 , 1 . I , I , I . 1 CatGIO 0lfr145 CafaOR5.2.5 HsOR11.18.36 LGVYVMGFAGAMAHTTCMVRLTFCANNLVDHYMCDILPLLERSCTSTYVN LGVYVMGFAGAMAHTAFMVKLTFCADKLVNHYMCDILPLLERSCTSTYVN LGVYVMGFAGAMAHTVCMVRLTFCANNLVDHYMCDILPLLERSCTSTYVN LGVYGMGFAGAMAHTACMMGVTFCANNLVNHYMCDILPLLECACTSTYVN 210 220 230 240 250 I i I i I i 1 CatGIO 0lfr145 CafaOR5.2.5 HsOR11.18.36 ELVVFVVVGIDIGVPTVTIFISYALILTSILHIRSTEGRSKAFSTCSSHI ELVVFIVVGIDIGVPTVTIFISYALILSSILRISSTEGRSKAFSTCSSHI ELVVFIVVGIDIGVPTVTIFISYALILSSILRIHSTKGRSKAFSTCSSHI ELVVFVVVGIDIGVPTVTIFISYALILSSIFHIDSTEGRSKAFSTCSSHI 260 270 280 290 300 , i , 1 CatGIO 0lfr145 CafaOR5.2.5 HsOR11.18.36 IAVSLFFGSGAFMYLKPSSLLPMNQGKVSSLFYTTVVPMLNPLIYSLRNK IAVSLFFGSGAFMYLKPSSLLPMNQGKVSSLFYTIVVPMLNPLIYSLRNK IAVSLFFGSGAFMYLKPSSLLPMNQGKVSSLFYTIVVPMLNPLIYSLRNK IAVSLFFGSGAFMYLKPPSLLAMNQGKVSSLFYTTVVPMLNPLIYSLRNK 310 320 330 340 350 , I , I , I , I , I CatGIO 0lfr145 CafaOR5.2.5 HsOR11.18.36 DVKVALKKSLSKKTFS DVKVALRKTLSRSSFS DVKIALKKTLSKKPFS DVKVALKKILNKNAFS

FIG. 11A

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

59/97

FIG. 11B

FIG. 11C

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

60/97

TYR77

FIG. 11E

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

61/97 transport

FIG. 12

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

CafaOR9_2_9

0R3A1

E1_13347030_13347977 Group 1

CafaOR18_3_12 0R5A1 ₄

D1J05462554J05463512 Group 9

CafaOR18_3_11

0R4D6

D1_105486528_105487493 Group 6 , Group 7

CafaORI 5_3_1 0R4E2

B3_74116955_74117893

Dog « Human - Cat

Group 10

CafaOR5_2_5

0R8B8

D1_21266824_21267768

Group 4

CafaOR21_2_43

0R51L1

D1_63312327_63313289

Group 3

CafaOR21_2_15 ₇ z 0R51E1 ' ‘ z D1_62955839_62956792 /

CafaORI 5_2_20 I 0R11H6 I

B3_72908295_72909287 I Group 5

Group 8

CafaOR6_3_1 o_R2d

E3_40237904_40238842

CafaOR38_1_21

0R6P1

F1_65134904_65135858 Group 2

FIG. 13

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

63/97

Vo \\\U 3§ σ,Οί O-o \\\w CTO O Z a o w CT>LlJ o or Q o \WW \\\\\ 4 0R51L1 £-o o[o -\\W Β m-* LxJ © or o o 1 σ»ο q δ \ww \ν C7>LlJ O Q± Q O 1 3 0R51E1 O o | -»-» LU © oi o o σ»ο o z o O // 1 '/M 1 ! C7>LlJ o o± a o cZ <5:o \W\\ 1111111 1 χ\ m-» LU © ο δ 1 ! o CTO o z O o ί ί cnLiJ o az Q O it w Hu £>o οδ w -h^'LU o;<5 xW\\ ο \\W CT>O o o w/ ct>LlJ o az a o \\\\\ υυ © c ₍O © 5 © E © £ I— © © >> © © © co ’© © 1 Ξ © □_ © ©^ © © © co C © _σ © 14—ethoxybenzaldehyde | Ο ’ο © ο ’k_ © © δ CO © ’ο © Ο ’l_ © © τ >> © Ε 1 © ’© σ ο ’© © σ X © τ ΡΜ 1 >> © Ε 1 *ο © ’ο © υ ’© ο © X © © © Ο © >* © © Ω. © © © § © © © © £ © © ο © ο Ί © 2D © © Ο © Ο Ί © ω. Ε ±± ο © § © ο © ϊ _α> © ο © s' © ο © © § © ο © X¹ © Ιο ‘© ο © © © ο © Ε © *© or ο © © © © ο ο © © σ © Ο © σ Ω. © Ε © Ε I © © ο © © Ω. Ο © £ © ’C © Ε © ο ο © © ο © © ο ’ω. ε □_ © σ Ε © ο δ- ο S Ε 1 ί-- ₍χ ΓΜ X

^OR without any responses Strong positive response M Weak positive response

FIG. 14

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

64/97 ^OR without any responses Strong positive response fflWeak positive response

FIG. 15

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

65/97 §2

CO

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

66/97 §2

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

67/97 βοα

TO

Ε·

Bog

IiwBog

TO

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FIG. 18 sbuDqo p|oj

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

10η ο Mock Human σ» ο

ο

68/97 |0U9J0|0jd0S| σ

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FIG. 19 sBuDqo p|oj

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620 □_ to

Qi

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69/97 |0U9J3)0jd0S|

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NW 720Ό

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FIG. 20 sBuDqo p|oj

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

ΗΞ

70/97 he

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FIG. 21 sbuDqo p|oj

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

71/97 βοα

TO ι6oq to

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FIG. 22 sBuDqo p|oj

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

72/97

Bog •P>W +/////////////////»

Bog c-Bog c-pop| >nw-Boq

C-PW

Bog

C-p)p|

Bog c->pofl

E-Bog c-pfl

0R51E1 c-Bog c-pop| tw-Bog c-p>fl

Bog c-p>R +//////////////////^7«

Bog c-p>fl

Bog c-p>H

Bog c-p>fl

Bog c-pw

Bog e-PW

E-Bog c->pofl

PO

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PO

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FIG. 23 o

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SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

73/97

Bog

PN c-Bog

ΕC-p>fl

E-Bog c-ρορι c-Bog nw-6og c-PN

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C-PN c-Bog

EE-PN fi-Bog

EC-pfl c-Bog c-PN

Bog c-pfl

E-Bog eC-R

40ί Ο Mock Human c-Bog c-pn

E-Bog c-pfl

PO udujiih

PO udujiih

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FIG. 24 ο

sbuDqo p|oj

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

74/97

Bog

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TO tWΕ·

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FIG. 25 sBuoqa p|oj

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620 co ο:

o

30 ί Ο Mock Human

CM

75/97

Bog

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FIG. 26 sBuDqa p|oj

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

CO ο:

ο

15η ο Mock Human

76/97

UO

Bog

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TO i^w-Boq

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FIG. 27 sBuoqa p|oj

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

77/97

6oq •P>N

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50 ί Ο Mock Human

ΙΌ CM sbuDqo p|OJ

Bog

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SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

87/97

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FIG. 38A

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SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

88/97

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FIG. 39A

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FIG. 39B

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

89/97

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FIG. 39C

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SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

90/97

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FIG. 40A

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SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

91/97

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FIG. 41A

FIG. 41B

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

92/97

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FIG. 42A

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SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

93/97

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FIG. 42C

FIG. 42D

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636 PCT/US2017/054620

94/97

FIG. 42E

FIG. 42F

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636 PCT/US2017/054620

95/97

FIG. 42G

FIG. 42H

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

96/97

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FIG. 43A

FIG. 43B

SUBSTITUTE SHEET (RULE 26)

WO 2018/064636

PCT/US2017/054620

97/97

FIG. 43C

SUBSTITUTE SHEET (RULE 26)

069269_0225_SL.TXT SEQUENCE LISTING <110> MARS, INCORPORATED <120> SCREENING METHODS USING OLFACTORY RECEPTORS AND PET FOOD PRODUCTS AND COMPOSITIONS IDENTIFIED USING THE SAME <130> 069269.0225 <140>

<141>

<150> 62/402,823 <151> 2016-09-30 <160> 3809 <170> PatentIn version 3.5 <210> 1 <211> 948 <212> DNA <213> Homo sapiens <400> 1

atgcagccag aatctggggc caatggaaca gtcattgctg agttcatcct gctgggcttg 60 ctggaggcgc cagggctgca gccagttgtc tttgtgctct tcctctttgc ctacctggtc 120 acggtcaggg gcaacctcag catcctggca gctgtcttgg tggagcccaa actccacacc 180 cccatgtact tcttcctggg gaacctatca gtgctggatg ttgggtgcat cagcgtcact 240 gttccatcaa tgttgagtcg tctcctgtcc cgcaagcgtg cagttccctg tggggcctgc 300 cttacccagc tcttcttctt ccatctgttc gttggagtgg actgcttcct gctgaccgcc 360 atggcctatg accgattcct ggccatctgc cggcccctca cctacagcac ccgcatgagt 420 cagacagtcc agaggatgtt ggtggctgcg tcctgggctt gtgctttcac caacgcactg 480 acccacactg tggccatgtc cacgctcaac ttctgtggcc ccaatgtgat caatcacttc 540 tactgtgacc tcccacagct cttccagctc tcctgctcca gcacccaact caatgagctg 600 ctgctttttg ctgtgggttt tataatggca ggtaccccca tggctctcat tgtcatctcc 660 tatatccacg tggcagctgc agtcctgcga attcgctctg tagagggcag gaagaaagcc 720 ttctccacat gtggctccca cctcactgtg gttgccatat tctatggttc aggtatcttt 780 aactatatgc gactgggttc aaccaagctt tcagacaagg ataaagctgt tggaattttc 840

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069269_0225_SL.TXT

aacactgtca tcaatcccat cagagtgcca tctggaggat gctgaaccca atcatctaca gcttcagaaa ccctgatgtg 900 948 gctcacaggg aggcggtcac tggcttga <210> 2 <211> 954 <212> DNA <213> Homo sapiens <400> 2 atgagaaatt tgagtggagg ccatgtcgag gagtttgtct tggtgggttt ccctaccacg 60 cctcccctcc agctgctcct ctttgtcctt ttttttgcaa tttaccttct gacattgttg 120 gagaatgcac ttattgtctt cacaatatgg cttgctccaa gccttcatcg tcccatgtac 180 tttttccttg gccatctctc tttcctggag ctatggtaca tcaatgtcac cattcctcgg 240 ctcttggcag cctttcttac ccaggatggt agagtctcct acgtaggttg catgacccaa 300 ctgtacttct ttattgcctt agcctgtact gaatgtgtgc tgttggcagt tatggcctat 360 gatcgctacc tggccatctg tggacccctc ctttacccta gtctcatgcc ttccagtctg 420 gccactcgcc ttgctgctgc ctcttggggc agtggcttct tcagctccat gatgaagctt 480 ctttttattt cccaattgtc ctactgtgga cccaacatta tcaaccactt tttctgtgat 540 atttccccac tactcaacct cacctgctct gacaaggagc aagcagagct agtagacttc 600 cttctggccc tggtgatgat tctactccct ctattggctg tggtttcatc atacactgcc 660 atcattgcag ccatcctgag gatccctacg tccaggggac gccacaaagc cttttccact 720 tgtgccgctc atctggcagt ggttgttatc tactactcct ccactctctt cacctatgca 780 cggccccggg ccatgtacac cttcaaccac aacaagatta tctctgtgct ctacactatc 840 attgtaccat tcttcaaccc agccatctac tgcctgagga acaaggaggt gaaggaggcc 900 ttcaggaaga cagtgatggg cagatgtcac tatcctaggg atgttcagga ctga 954

<210> 3 <211> 956 <212> DNA <213> Homo sapiens <400> 3 atgatggtgg atcccaatgg caatgaatcc agtgctacat acttcatcct aataggcctc 60

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cctggtttag aagaggctca gttctggttg gccttcccat tgtgctccct ctaccttatt 120 gctgtgctag gtaacttgac aatcatctac attgtgcgga ctgagcacag cctgcatgag 180 cccatgtata tatttctttg catgctttca ggcattgaca tcctcatctc cacctcatcc 240 atgcccaaaa tgctggccat cttctggttc aattccacta ccatccagtt tgatgcttgt 300 ctgctacaga tgtttgccat ccactcctta tctggcatgg aatccacagt gctgctggcc 360 atggcttttg accgctatgt ggccatctgt cacccactgc gccatgccac agtacttacg 420 ttgcctcgtg tcaccaaaat tggtgtggct gctgtggtgc ggggggctgc actgatggca 480 ccccttcctg tcttcatcaa gcagctgccc ttctgccgct ccaatatcct ttcccattcc 540 tactgcctac accaagatgt catgaagctg gcctgtgatg atatccgggt caatgtcgtc 600 tatggcctta tcgtcatcat ctccgccatt ggcctggact cacttctcat ctccttctca 660 tatctgctta ttcttaagac tgtgttgggc ttgacacgtg aagcccaggc caaggcattt 720 ggcacttgcg tctctcatgt gtgtgctgtg ttcatattct atgtaccttt cattggattg 780 tccatggtgc atcgctttag caagcggcgt gactctccgc tgcccgtcat cttggccaat 840 atctatctgc tggttcctcc tgtgctcaac ccaattgtct atggagtgaa gacaaaggag 900 attcgacagc gcatccttcg acttttccat gtggccacac acgcttcaga gcccta 956 <210> 4 <211> 948 <212> DNA <213> Homo sapiens <400> 4 atgggagact ggaataacag tgatgctgtg gagcccatat ttatcctgag gggttttcct 60 ggactggagt atgttcattc ttggctctcc atcctcttct gtcttgcata tttggtagca 120 tttatgggta atgttaccat cctgtctgtc atttggatag aatcctctct ccatcagccc 180 atgtattact ttatttccat cttagcagtg aatgacctgg ggatgtccct gtctacactt 240 cccaccatgc ttgctgtgtt atggttggat gctccagaga tccaggcaag tgcttgctat 300 gctcagctgt tcttcatcca cacattcaca ttcctggagt cctcagtgtt gctggccatg 360 gcctttgacc gttttgttgc tatctgccat ccactgcact accccaccat cctcaccaac 420

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069269_0225_SL.TXT

agtgtaattg gcaaaattgg tttggcctgt ttgctacgaa gcttgggagt tgtacttccc 480 acacctttgc tactgagaca ctatcactac tgccatggca atgccctctc tcacgccttc 540 tgtttgcacc aggatgttct aagattatcc tgtacagatg ccaggaccaa cagtatttat 600 gggctttgtg tagtcattgc cacactaggt gtggattcaa tcttcatact tctttcttat 660 gttctgattc ttaatactgt gctggatatt gcatctcgtg aagagcagct aaaggcactc 720 aacacatgtg tatcccatat ctgtgtggtg cttatcttct ttgtgccagt tattggggtg 780 tcaatggtcc atcgctttgg gaagcatctg tctcccatag tccacatcct catggcagac 840 atctaccttc ttcttccccc agtccttaac cctattgtct atagtgtcag aacaaagcag 900 attcgtctag gaattctcca caagtttgtc ctaaggagga ggttttaa 948 <210> 5 <211> 993 <212> DNA <213> Homo sapiens <400> 5 atgttcttta ttattcattc tttggttact tctgtttttc taacagcttt gggaccccag 60 aacagaacaa tgcattttgt gactgagttt gtcctcctgg gtttccatgg tcaaagggag 120 atgcagagct gcttcttctc attcatcctg gttctctatc tcctgacact gctagggaat 180 ggagctattg tctgtgcagt gaaattggac aggcggctcc acacacccat gtacatcctt 240 ctgggaaact ttgcctttct agagatctgg tacatttcct ccactgtccc aaacatgcta 300 gtcaatatcc tctctgagat taaaaccatc tccttctctg gttgcttcct gcaattctat 360 ttcttttttt cactgggtac aacagagtgt ttctttttat cagttatggc ttatgatcgg 420 tacctggcca tctgtcgtcc attacactac ccctccatca tgactgggaa gttctgtata 480 attctggtct gtgtatgctg ggtaggcgga tttctctgct atccagtccc tattgttctt 540 atctcccaac ttcccttctg tgggcccaac atcattgacc acttggtgtg tgacccaggc 600 ccattgtttg cactggcctg catctctgct ccttccactg agcttatctg ttacaccttc 660 aactcgatga ttatctttgg gcccttcctc tccatcttgg gatcttacac tctggtcatc 720 agagctgtgc tttgtattcc ctctggtgct ggtcgaacta aagctttctc cacatgtggg 780 tcccacctaa tggtggtgtc tctattctat ggaaccctta tggtgatgta tgtgagccca 840

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069269_0225_SL.TXT

acatcaggga acccagcagg aatgcagaag atcatcactc tggtatacac agcaatgact 900 ccattcttaa atccccttat ctatagtctt cgaaacaaag acatgaaaga tgctctaaag 960 agagtcctgg ggttaacagt tagccaaaac tga 993 <210> 6 <211> 942 <212> DNA <213> Homo sapiens <400> 6 atggaccaga tcaaccacac taatgtgaag gagtttttct tcctggaact tacacgttcc 60 cgagagctgg agtttttctt gtttgtggtc ttctttgctg tgtatgtagc aacagtcctg 120 ggaaatgcac tcattgtggt cactattacc tgtgagtccc gcctacacac tcctatgtac 180 tttctcctgc ggaacaaatc agtcctggac atcgtttttt catctatcac cgtccccaag 240 ttcctggtgg atcttttatc agacaggaaa accatctcct acaatggctg catggcacag 300 atctttttct tccactttgc tggtggggca gatatttttt tcctctctgt gatggcctat 360 gacagatacc ttgcaatcgc caagcccctg cactatgtga ccatgatgag gaaagaggtg 420 tgggtggcct tggtggtggc ttcttgggtg agtggtggtt tgcattcaat catccaggta 480 attctgatgc ttccattccc cttctgtggc cccaacacac tggatgcctt ctactgttat 540 gtgctccagg tggtaaaact ggcctgcact gacacctttg ctttggagct tttcatgatc 600 tctaacaacg gactggtgac cctgctctgg ttcctcctgc tcctgggctc ctacactgtc 660 attctggtga tgctgagatc ccactctggg gaggggcgga acaaggccct ctccacgtgc 720 acgtcccaca tgctggtggt gactcttcac ttcgtgcctt gtgtttacat ctactgccgg 780 cccttcatga cgctgcccat ggacacaacc atatccatta ataacacggt cattaccccc 840 atgctgaacc ccatcatcta ttccctgaga aatcaagaga tgaagtcagc catgcagagg 900 ctgcagagga gacttgggcc ttccgagagc agaaaatggg gg 942 <210> 7 <211> 939 <212> DNA <213> Homo sapiens

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069269_0225_SL.TXT <400> 7

atggacagtc taaaccaaac aagagtgact gaatttgtct tcttgggact cactgataac 60 cgggtgctgg aaatgctgtt tttcatggca ttctcagcca tttatatgct aacgctttca 120 gggaacattc tcatcatcat tgccacagtc tttactccaa gtctccatac ccccatgtat 180 ttcttcctga gcaatctgtc ctttattgac atctgccact catctgtcac tgtgcctaag 240 atgttggagg gtttgctttt agaaagaaag accatttcct ttgacaactg catcacacag 300 ctcttcttcc tacatctctt tgcctgtgcc gagatctttc tgctgatcat tatggcgtat 360 gatcgttacg tggctatctg cactccactc cactacccca atgtgatgaa catgagagtc 420 tgtatacagc ttgtctttgc tctctggttg gggggtactg ttcactcact agggcagacc 480 ttcttgacta ttcgtctacc ttactgtggc cccaacatta ttgacagcta cttctgtgat 540 gtgcctcttg ttatcaagct ggcctgcaca gatacatacc tcacaggaat actgattgtg 600 accaatagtg gaaccatctc cctctcctgt ttcttggccg tggtcacctc ctatatggtc 660 atcctggttt ctcttcgaaa acactcagct gaagggcgcc gtaaagccct gtctacctgc 720 tcggcccact tcatggtggt tgccctcttc tttgggccat gtatcttcat ctatactcgg 780 ccagacacca gcttctccat tgacaaggtg gtgtctgtct tctacacagt ggtcacccct 840 ttgctgaatc ccttcattta caccttgagg aatgaggagg taaaaagtgc catgaagcag 900 ctcaggcaga gacaagtttt tttcacgaaa tcatataca 939 <210> 8 <211> 939 <212> DNA <213> Homo sapiens <400> 8 atggacgggg tgaatgatag ctccttgcag ggctttgttc tgatgggcat atcagaccat 60 ccccagctgg agatgatctt ttttatagcc atcctcttct cctatttgct gaccctactt 120 gggaactcaa ccatcatctt gctttcccgc ctggaggccc ggctccatac acccatgtac 180 ttcttcctca gcaacctctc ctccttggac cttgctttcg ctactagttc agtcccccaa 240 atgctgatca atttatgggg accaggcaag accatcagct atggtggctg cataacccag 300 ctctatgtct tcctttggct gggggccacc gagtgcatcc tgctggtggt gatggcattt 360

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069269_0225_SL.TXT

gaccgctacg tggcagtgtg ccggcccctc cgctacaccg ccatcatgaa cccccagctc 420 tgctggctgc tggctgtgat tgcctggctg ggtggcttgg gcaactctgt gatccagtca 480 acattcactc tgcagctccc attgtgtggg caccggaggg tggagggatt cctctgcgag 540 gtgcctgcca tgatcaaact ggcctgtggc gacacaagtc tcaaccaggc tgtgctcaat 600 ggtgtctgca ccttcttcac tgcagtccca ctaagcatca tcgtgatctc ctactgcctc 660 attgctcagg cagtgctgaa aatccgctct gcagagggga ggcgaaaggc gttcaatacg 720 tgcctctccc atctgctggt ggtgttcctc ttctatggct cagccagcta tgggtatctg 780 cttccggcca agaacagcaa acaggaccag ggcaagttca tttccctgtt ctactcgttg 840 gtcacaccca tggtgaatcc cctcatctac acgctgcgga acatggaagt gaagggcgca 900 ctgaggaggt tgctggggaa aggaagagaa gttggctga 939 <210> 9 <211> 948 <212> DNA <213> Homo sapiens <400> 9 atgtccataa ccaaagcctg gaacagctca tcagtgacca tgttcatcct cctgggattc 60 acagaccatc cagaactcca ggccctcctc tttgtgacct tcctgggcat ctatcttacc 120 accctggcct ggaacctggc cctcattttt ctgatcagag gtgacaccca tctgcacaca 180 cccatgtact tcttcctaag caacttatct ttcattgaca tctgctactc ttctgctgtg 240 gctcccaata tgctcactga cttcttctgg gagcagaaga ccatatcatt tgtgggctgt 300 gctgctcagt tttttttctt tgtcggcatg ggtctgtctg agtgcctcct cctgactgct 360 atggcatacg accgatatgc agccatctcc agcccccttc tctaccccac tatcatgacc 420 cagggcctct gtacacgcat ggtggttggg gcatatgttg gtggcttcct gagctccctg 480 atccaggcca gctccatatt taggcttcac ttttgcggac ccaacatcat caaccacttc 540 ttctgcgacc tcccaccagt cctggctctg tcttgctctg acaccttcct cagtcaagtg 600 gtgaatttcc tcgtggtggt cactgtcgga ggaacatcgt tcctccaact ccttatctcc 660 tatggttaca tagtgtctgc ggtcctgaag atcccttcag cagagggccg atggaaagcc 720 tgcaacacgt gtgcctcgca tctgatggtg gtgactctgc tgtttgggac agcccttttc 780

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gtgtacttgc gacccagctc cagctacttg ctaggcaggg acaaggtggt gtctgttttc 840 tattcattgg tgatccccat gctgaaccct ctcatttaca gtttgaggaa caaagagatc 900 aaggatgccc tgtggaaggt gttggaaagg aagaaagtgt tttcttag 948 <210> 10 <211> 936 <212> DNA <213> Homo sapiens <400> 10 atggctgctg agaattcctc cttcgtgaca cagtttatcc tcgcaggctt aactgaccaa 60 ccgggagtcc agatccccct cttcttcctg tttctaggct tctacgtggt cactgtggtg 120 gggaacctgg gcttgataac cctgataagg ctcaactctc acttgcacac ccctatgtac 180 ttcttcctct ataacttgtc cttcatagat ttctgctatt ccagtgttat cactcccaaa 240 atgctgatga gctttgtctt aaagaagaac agcatctcct acgcagggtg tatgactcag 300 ctcttcttct ttcttttctt tgttgtctct gagtccttca tcctgtcagc aatggcgtat 360 gaccgctatg tggccatctg taacccactg ttgtacatgg tcaccatgtc tccccaggtg 420 tgttttctcc ttttgttggg tgtctatggg atggggtttg ctggggccat ggcccacaca 480 gcgtgcatga tgggtgtgac cttctgtgcc aataaccttg tcaaccacta catgtgtgac 540 atccttcccc ttcttgagtg tgcttgcacc agcacctatg tgaatgagct tgtagtgttt 600 gttgttgtgg gcattgatat tggtgtgccc acagtcacca tcttcatttc ctatgctctc 660 attctctcca gcatcttcca cattgattcc acggagggca ggtccaaagc cttcagcacc 720 tgcagctccc acataattgc agtttctctg ttctttgggt caggagcatt catgtacctc 780 aaaccctttt ctcttttagc tatgaaccag ggcaaggtgt cttccctatt ctataccact 840 gtggtgccca tgctcaaccc attaatttat agcctgagga ataaggacgt caaagttgct 900 ctaaagaaaa tcttgaacaa aaatgcattc tcctga 936 <210> 11 <211> 948 <212> DNA <213> Canis familiaris

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069269_0225_SL.TXT <400> 11

atgcagtcaa aatttggggc caatagcaca gccattactg agttcatcct gctgggcttg 60 gtggacacac cagggctaca accagttgtc tttgtagtct tcctctttgc ctacctggtc 120 acagtcggag gcaacctcag catcctggct gccatcttgg tggaacccaa actccacacg 180 cccatgtact tcttcctggg gaacctgtca gtgctggatg ttgggtgcat cactgtcact 240 gttccctcaa tgttggctcg cctcttgtcc cacaaacgta cagttcccta cagagcctgc 300 ctcacacaac tcttcttctt ccatctcttg gttggggtgg actgcttcct gttgacagcc 360 atggcctatg accgattcct ggccatctgc cggcccctca cctacagcac ccagatgagc 420 cagacagtcc agagaatatt ggtagttgtg tcctgggctt tagccttcac caatgcactg 480 acccacacag tagccatagc cacactcaac ttttgtggtc ctaatgtgat caaccacttc 540 tactgcgacc tcccacagct cttccagctc tcctgctcca gcactcagct caatgagctg 600 ctgctctttg ctgtgggttt cataatggca ggtaccccct tggctctcat catcacttcc 660 tatgcacatg tggcagctgc agtcctaaga atccgctctg ctgagggcag gaagaaagct 720 ttctctacat gtggctctca tctcactgtg gtagccatat tctatggttc aggtatattt 780 aattacatgc gactgggtac agccaagcat tcagacaagg ataaaggggt tggggtcttc 840 aacactgtca tcaaccccat gctgaatcca atcatttaca gcctcaggaa ccttgatgta 900 cagggtgccc tctggcgggt gctcagggga aggcagtcac tggcttga 948

<210> 12 <211> 957 <212> DNA <213> Canis familiaris <400> 12 atgatgggaa atttgagtgg aggccacata gcagatttta ttttggtggg cttcccaacc 60 tctccacccc tccagttact tctctttgtc ctcttctttg caatttacct gttgacactg 120 ttggagaatg cactcatcgt ttccacaatc tggctcactc caagccttca ccgcccgatg 180 tactttttcc ttggccatct gtccttcctg gagctgtggt acatcaatgt cacagttcct 240 cgtcttttgg gagcatttct tacccaggac cgtagagtct cctatgtagg ctgcatgacc 300 cagctctact tcttcattgc cctagcctgc accgaatgtg tcctgctggc agtcatggcc 360

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069269_0225_SL.TXT tatgaccgct acctggccat ctgtgagccc ctccgttatc ctagtctcat gccgtccagc 420 ctggccattc gccttgctgc ttcctcttgg ggtggtggct tcttcagctc catgatgaag 480 cttcttttca tttcccgact gtcctactgt gggcccaaca tcatcaacca ttttttctgt 540 gatatctccc cactactcaa ccttacctgc tctgacaagg agcaagcaga actagtagac 600 ttcctgttgg ccctggtgat gatcctgctt cctctactgg ctgtggtttc atcatatgct 660 gccatcattg ccaccatcct gaggatccct actgcccagg gacgtcgcaa agccttttcc 720 acctgtgcct ctcacctggc agtggttgtc atctactact cctccaccct cttcacctat 780 gcaaggcccc gggccatgta caccttcaac cacaacaaga tcatctctgt gctctatacg 840 gtcattgtac cattcctcaa tccagccatc tactgcctga ggaacaagga ggtgaaggat 900 gctctcagga agttggttct gggcagatgc cactatccta gtgatgtccc agactga 957 <210> 13 <211> 954 <212> DNA <213> Canis familiaris

<400> 13 atggtggacc ccaatggcaa tgaatccagt gccacatatt ttattttaat aggcctccca 60 ggcttggaag aagctcagtt ctggttggcc ttccccttgt gctccctcta ctttattgct 120 gtattgggta acctgacaat catctacatt gtgcggactg agcacagcct acatgaaccc 180 atgtatgttt ttctttgcat gctttctggc cttgacatcc ttatctccac ctcatctatg 240 cccaaaatga tggccatctt ctggttcaat tccactacca tccagtttga tgcttgtcta 300 ctacagatgt ttgccatcca ttctttatct ggcatggagt ccacagtact gctggccatg 360 gcctttgacc gctatgtggc catttgccac ccactacgcc atgccactgt actaacattg 420 cctcgtgtta tgaagattgg catggctgct gtggtacggg gtactgcact tatggcaccc 480 ctgcctgttt ttatcaaacg actgcctttc tgccactcca acattctttc ccattcctac 540 tgcctacacc aagatgtcat gaagctggct tgtgctgaca tccgtgtcaa tatcatctat 600 ggcctcattg tcatcatctc tgccattggc ctggactcac ttctcatctc cttgtcatat 660 ctacttatcc tcaagactgt gttgggcttg acacgtgaag cccaggcaaa ggcatttggc 720 acttgtgtct ctcatgtatg tgctgttttc atattctatg Page 10 tacctttcat tggattatct 780

069269_0225_SL.TXT

atggtgcacc gctttggcaa gagacatgac tccttcctgc ccatcattat ggccaacacc 840 tacctacttg tacctcctgt gctcaacccc attgtttatg gagtcaagac aaaggagatc 900 tggcagcgta tccttcgtct tttccatgtg accaaccata cttcagatct ctag 954 <210> 14 <211> 963 <212> DNA <213> Canis familiaris <400> 14 atgccaaggg tcaccatggt ggtctggaat aacaataaca ctctggagcc catatttatt 60 ctgaagggat ttcctgggtt ggagtgtgtt cattcttggt tctcaatccc tttctgtctt 120 gcgtacttgg tagcatttat tggtaatgtc accatcctct ctgtcatctg gatagagtcc 180 tcactccacc agcccatgta ttactttctt tccatcttgg cactgactga cctaggcatg 240 tccatgtcca cacttcccac catgcttgct gtgttatggc tggatgctag agagatccag 300 gcaagtgctt gctatgctca gctcttcttc atccacacat tcacattcct ggagtcttcg 360 gtgctattgg ccatggcctt cgatcgtttt gttgctatct gccgtccact gcactacacc 420 accatcctta acaacagtgt aataggcaag attggcttgg cctgcttgct aagaagcatg 480 ggagttgtac ttcctacacc tttgctactg agacattatc actactgcca tgtcaatgcc 540 ctttcccatg ccttctgttt gcaccaagac gttctcaaat tgtcctgttc agatgccagg 600 atcagcagtg tctatggact gtgtgtagtc atcactacac tgggcatgga ttcagtcttc 660 atacttcttt cttatgtcct gattttgaat gctgtgctgg gcatagcatc tcatgaagag 720 cggctaaagg cactcaacac atgtgtgtcc catatctgcg tggtgctcat tttctttgtg 780 ccagttattg gggtgtcaat ggtccatcgc tttgggaaac atctgtctcc catagttcac 840 atcatcatgg ctgatattta cttgcttttc cccccagtac ttaaccctat tgtctatagt 900 gtcaggacaa agcagattcg tataagaatt ttccacaagt taagactagg gaggaggctt 960 taa 963 <210> 15 <211> 993 <212> DNA

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069269_0225_SL.TXT <213> Canis familiaris <400> 15 atgctcatca ttattcactc attggttatc tctgcttctc taacagcttt ggaatcccag 60 aacacaacaa tgcgttttgt gtctgagttt gtcctcctgg gtttccctgg tcaaagggag 120 atgcagaact ttttcttctc attcatcctg gtgatctatc tcctcaccct gctggggaat 180 gggattattg tctgcatagt gaaatgggac aagcagcttc acacacccat gtacatcttc 240 ttgggaaact ttgccttcct agagatctgg tacacctcct ccactgtccc aagtatgctg 300 gtcaacatcc tttccgagac caagaccatc tccttcactg ggtgcttcct tcaattctac 360 ttctttttct cactgggtac aacagagtgt ttcttcttat cagtcatggc ttatgatcgg 420 tacctcgcca tctgtcgccc actccattac ccctccatca tgactgggaa gctctgtgtg 480 gccctggtct gtgtttgctg ggtgagtgga tttctctgct atccagtccc cattgtcctc 540 atctcccaac ttccattctg tggacccaac atcattgatc actttgtgtg tgacccaggc 600 ccactgttcg cactggcctg catccctgct ccttccactg agcttctctg ttacaccttc 660 aattcactga ttatcttcgg gcccttcctc ttcatcctgg gatcttacac cctggttctc 720 agagctgtgc ttcgcattcc ttctggtgca ggtcgaacta aagcattctc cacgtgtggg 780 tcccatctaa tggtggtgtc tctattctat ggaaccctta tggtgatgta tgtgagcccg 840 acatcaggga atccgacggg aatgcaaaag atcatcactc tggtatactc ggcagtgact 900 ccactcttaa acccccttat ctatagtctc cgaaacaaag acatgaaaga tgccctaaag 960 aaagtcctag gattaagaag taaccaaaac tga 993 <210> 16 <211> 936 <212> DNA <213> Canis familiaris <400> 16 atgggccaga gcaaccacac caatgtgaag gaatttgtct ttctgaaact cactcacttc 60 cacgagctag aattgttctt gtttgtggtc ttccttgctg tatatgtagc aactgtgctg 120 ggcaatgtcc tcattgtggt gaccatcacc tgtgagtccc acctccactc tcccatgtac 180 tttctgctgc ggaacaaatc agtcctggac attgtctttt catctgtcac tgttcccaag 240

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069269_0225_SL.TXT ttcctggtgg atctgttatc agagagaaaa accatctcct acaatggctg catggcacag 300 atcttcttct tccacttcgc tggtggggca gacattttct tcctctctgt gatggcctat 360 gacaggtacc ttgcaatcgc caaacccctg cattatgtga ccattatgag gagagagacg 420 tgggtgggct tggtggtggc ttcctgggtg ggtggtggtt tgcactcaat tgtccaggta 480 actctcatgc ttccactccc tttctgtggc cccaacatcc tggatgcctt ctactgtgat 540 gtgccccaag tgattaagct ggcctgtacc aacacctttg ccctggagct tctcatgatc 600 tctaacaatg ggctggtgac cctgctgtgg ttcctcctgc tcctgggctc ctacactgtc 660 attctggtga tgctgagatc tcactctggg gaggggcgga ataaggccct gtccacctgc 720 acttcccata tcttcgtggt gaccctgcac ttcgtgcctt gcgtctacat ctactgccgg 780 cccttcatca cgctgcccat ggacacagtt gtatccatca ataacacagt cattaccccc 840 atgctgaacc ccatgatcta tacactgagg aaccaggaga tgaagtcagc catgaaaaga 900 ctgcagagaa ggcttggacc ttctgagagc agttag 936 <210> 17 <211> 927 <212> DNA <213> Canis familiaris <400> 17 atggaggctc cgaatcaaac aagagtgact gagtttgtct tcttggggct cacagataac 60 tgggcgctgg ggacgctact ttttgtggca ttctccctgg cttatgtgct cacccttctg 120 gggaacactc tcatcatagt gaccacggcc cttacccggc gcctccatac ccccatgtac 180 ttcttcctga gcaacctgtc cttcattgac acctgccact cctcggtcac tgtgcccaag 240 atgctggagg gcctgcttag ggagagaaag actatttcct ttgatgactg cattgcgcag 300 ctcttcttcc tacacctgtt cgcttgtgct gagatccttc tgctgaccgt catggcttac 360 gaccgctacg tggccatctg tgccccgctg cgctacccca acgtgatgag catccgggtg 420 tgtgtgcagc tcgtcctcgc cctctggtgg gggggtaccg ttcactctct ggtgcagacc 480 ctcctgacca ttcgtttgcc ctactgcggc cccaacgtta tcgatagcta cttctgcgat 540 gtgccccccg tcatcaagct ggcctgcacg gacacctacc tcacgggagt gctcattgtc 600 tccaacagtg gaaccatctc cctcacctgt ttcctggctt tggtcacctc ttacacaatc 660

Page 13

069269_0225_SL.TXT atcctggtgt ctcttagaaa acagtctgct gaagggcgcc ggaaagctct gtctacgtgc 720 tcagcccact tcatggtggt cgccttcttc tttggaccat gcatcttcat ctacactcgg 780 ccagacacca gcttctccat cgacaaggtg gtatctgtct tctacaccgt ggtcacccct 840 ttgctaaatc ccctcattta caccttgagg aatgaggagg taaaaagtgc cataaagcat 900 ctcagacaga aacaggtttt ctcataa 927 <210> 18 <211> 939 <212> DNA <213> Canis familiaris <400> 18 atgccagagg ccaacgacag cttcctggag ggcttcattc tgatgggtat atctgaccat 60 ccccagctgg agataatctt tttcatggtc attctcttct cttacttact gactctgctt 120 gggaactcaa ccattatcct gctttcctgg ctggatgccc ggctccatac tcccatgtac 180 ttcttcctca gcaacctctc caccctggac cttgctttta ctactagctc agtcccccaa 240 atgctgatca acttatgggg accagataag accataagct atggtggctg tgtgacccag 300 ctctatgttt tcctctggct aggggccact gagtgtatcc tgcttgtggt gatggcgttt 360 gaccgctatg tggcagtttg ccggcccctg cactacacca ccatcatgaa ccctcggctc 420 tgctggctgc tggctgccat tgcatggctg ggtggcttga gcaactctgt gatccagtca 480 accttcactc tgcagctccc cttatgtggg caccggaggg tggacaactt cctgtgtgag 540 gtacctgcca tgatcaaact ggcctgtgga gacacgagtc tcaatgaggt tgtgctcaat 600 ggtgtctgca ccttcttcac tgctgtccca ctaagtgtca tcctgatctc ctactgctac 660 atagctcagg cagtgctgaa gatccactca gtagagggac agagaaaggc ctttaatacg 720 tgcctctcac atctggtggt ggtgttgctc ttctatggct cagctatcta tgggtatctc 780 cttccagcta agaccagcaa ccaggaccag ggcaaattca tttccctctt ctactctgtg 840 gtcacaccaa cggtgaaccc tctcatctac actctgagaa atagggaagt aaagggagca 900 ctaaggaggc tgctaggaaa gggaagatca cttggctga 939 <210> 19

Page 14

069269_0225_SL.TXT <211> 960 <212> DNA <213> Canis familiaris

<400> 19 atgtccacag ttaaggcctg gaacagctct tcagtgacca tgttcatcct cctgggattt 60 gcagaccatc cagaactgca gactcttctc tttgtgacct tcctgagtat ctatcttgtg 120 acactggcct ggaacctggc cctcatcttt ctgatcagaa gtgaccccca tctgcacaca 180 cccatgtact tcttcctcag caacttgtcc ttcattgaca tctgttattc ttccacagtg 240 gcccccaaga tgctcactga tttcttccag gagcaaaaga ccatctcgtt cttgggctgt 300 gctgctcagt tttttttctt tgtcagcatg ggtctcactg agtgcttcct tctgactgcc 360 atggcatatg atcgatacgc agccatctcc aaccccttgc tctacactgc catcatgtcc 420 cagggcctct gtacacgcat ggtgctgggg gcatatgtcg gtggtttcct gagctccttg 480 atccaggcca tctctatatt tcagctccac ttctgtggac ccaatatcat caaccatttc 540 ttctgtgacc ttccaccagt cctggcactt tcttgctctg acaccttccc tagtcaagtg 600 gtgaattttc tcatagtgat cactgttggg ggaacatcat tcctcatcct cctcatctcc 660 tacagttaca taggagctgc tgtcttgaag atccgctcag tggaaggccg aaggaaagcc 720 ttcaacacat gtgcctcgca tctgatggtg gtgactcttc tgtttgggac agctcttttc 780 atgtacctgc ggcccagctc cagctactca cttgccaggg acaaggtggt gtctgtcttc 840 tattcgctgg tgatccccat gctgaaccct ctcatttaca gtctaaggaa cagagatatc 900 aaagacgccc tgtggaaggc attggagaag aagaaagtgt ttttcctaga tcatgattga 960

<210> 20 <211> 948 <212> DNA <213> Canis familiaris

<400> 20 atgcctttag taagaatggc agctgagaat tcctctgtga cagagtttat cctctcaggc 60 ttaaccaacc agccaggact ccagattcct ctcttcttcc tgtttctagg tttctatgtg 120 gtcacggtgg tagggaacct gggcctgata accctgattg ggctgaattc tcacctgcac 180 acccccatgt actttttcct cttcaacttg tccttcatag atttctgcta ttccactgtt 240

Page 15

069269_0225_SL.TXT

atcactccca agatgctgat gaattttgtc ttgaggaaga acgtcatctc ctacgcaggg 300 tgtatgactc agctcttctt ctttctcttc tttgttgtat ctgagtcctt catcctgtca 360 gcaatggcat atgaccgcta tgccgccatc tgtaacccac tggtatacac tgccaccatg 420 tctcctcagg tctgcttcct ccttctgttg ggtgtctatg tgatggggtt tgctggagcc 480 atggcccaca cagtgtgcat ggtaagactg accttctgtg ccaacaatct ggttgaccac 540 tacatgtgcg acatccttcc ccttcttgag cgttcttgca ccagcaccta tgtcaatgag 600 ctggtagttt ttattgttgt gggcattgat attggtgtgc ccacagttac catcttcatt 660 tcttatgccc tcatcctctc cagcattctc cgtattcatt ctaccaaggg caggtccaaa 720 gccttcagca cctgcagctc ccacataatt gctgtttccc tcttctttgg atcaggggca 780 tttatgtacc tcaaaccatc ctctctttta cctatgaatc aggggaaagt gtcctctttg 840 ttctacacca tcgttgtgcc catgctcaac ccactaatct acagcttgag gaataaggat 900 gtcaaaattg ctctgaagaa aacactgagc aagaaaccat tctcttga 948

<210> 21 <211> 948 <212> DNA <213> Felis catus

<400> 21 atgaagtcaa aatttgagta caatagaaca gccattactg agttcatcct gctgggctta 60 gtggagacac cagacctgcg gccagttgtc tttgtagtct tcctcctttc ctacctgctc 120 acagttgggg gcaacctcag catcctggcc gccatcttgg tggagcccaa actccacacc 180 cccatgtact tcttcctggg gaacctatcg gtgctggaca ttgggtgcat cacagtcact 240 attccctcaa tgttggctcg tctcctgtcc cacaagcgta ctgttcccta tggagcctgc 300 ctcacacagc ttttcttctt tcaccttctc gttggggtgg actgcttcct tttgacagcc 360 atggcctatg accgattcct ggccatctgc cagcccctca cctacagcac ccgaatgagc 420 cagacagtcc agaggatatt ggtggctgtg tcctgggctt tagccttcac taatgcactg 480 acccacacag tagccatatc caccctgaac ttctgtggtc ccaatgtgat caatcacttc 540 tactgtgacc tcccacagct cttccagctc tcctgctcca gcacccaact caatgagttg 600 ctgctctttg ctgtgggttt cataatggca ggtactcccc Page 16 tggctctcat cgtcacctcc 660

069269_0225_SL.TXT tatgcccatg tgacagctgc agtcctacga atccgttctg ctgagggcag gaagaaagcc 720 ttctccacat gtggctctca tctcactgtg gttgccatat tctacggttc aggtatattt 780 aattacatgc gactgggttc agccaagctt tcagacaagg ataaagcttt tggaattttt 840 aacaccgtca tcaaccccat gctgaatcca atcatctaca gcctcaggaa ccctgacgtg 900 cagggtgccc tctggagagt gctcatgggg aggcggccac tggcttga 948 <210> 22 <211> 954 <212> DNA <213> Felis catus <400> 22 atgggaaatt ggagcagagg ccacatagca gagttcgtgt tggtgggctt ccctacctct 60 ccgcccctcc agtgcctcct ctttgtcctc ttcctggcaa tttacctgtt gacattgttg 120 gagaacgcac tcatcgtttc cacagtctgg ctcacgccaa gccttcaccg cccgatgtac 180 tttttccttg gccatctctc cttcctggag ctgtggtaca tcaatgtcac agttccccgg 240 cttttgggag catttcttac ccaggagcgt agagtctcct acgtaggctg catgactcag 300 ctctacttct ttattgccct agcctgcacc gaatgtgtcc tgctggcggt catggcctat 360 gaccgctacc tggccatctg tgagcccctc cgttatccta gtctcatgcc atccagcctg 420 gccattcgcc tcgctgcttc ctcttggggt agtggcttct tgagctccat gatgaagctt 480 cttttcattt cccggctgtc ctactgtgga cccaacgtca tcaaccactt tttctgcgat 540 atctccccac tactcaacct cacctgctct gacaaagagc aagcagaact agtagacttc 600 ctcttggccc tggtgatgat tctgctccct ctgttggccg tggtttcatc atatgctgcc 660 ataatggctg ccatcctcag gattcctact gcccagggac gtcgcaaagc cttctccacc 720 tgtgcctctc acctggcagt ggttgttatc tactactcct ccaccctctt cacctatgca 780 cggccccagg ccatgtacac cttcaaccat aacaaggtca tctctgtgct ctatacagtc 840 attgtaccgt tcctcaatcc agccatctac tgcctgagga acaaggaggt gaaggatgct 900 ctcaggaagt cagtcctggg cagatgccac tatccgaggg acgtcccaga ttga 954 <210> 23

Page 17

069269_0225_SL.TXT <211> 954 <212> DNA <213> Felis catus <400> 23

atggtggaca ccaatggcag tgaatctagt gccacatatt tcattctaat aggccttcca 60 ggcttggaaa aagctcagtt ctggttggcc ttcccgttat gctccctcta ccttattgct 120 gtgctaggta acctgacagt catctgcatt gtgcggactg agcacagact acatgaaccc 180 atgtatattt ttctttgcat gctttctggc cttgacatac ttatctctac ttcatctatg 240 cccagaatga tggccatctt ctggttcaat tccactacca tccagtttga tgcttgtctt 300 ctacagatgt ttgccatcca ctccttatct ggcatggagt ccactgtact gctggccatg 360 gcctttgacc gctatgtggc catttgtcac ccactacgcc atgccactgt gctaacattg 420 cctcgtgtta ccaagattgg cgtggctgct gtggtacggg gtacttcact tatggcaccc 480 ctgcctatct tcatcaaacg gctgcctttc tgccgctcca acattctttc ccattcctac 540 tgcctacatc aagatgtcat gaagctggct tgtgctgaca tccgtgtcaa tatcatctat 600 ggcctcattg tcatcatctc tgccattggc ctggactcac ttctcatctc cttgtcatat 660 ctgcttatcc tcaagactgt gttgggcttg acacgtgaag cccaggcaaa ggcatttggc 720 acttgtgtct ctcatgtgtg tgctgttttc atattctatg tacctttcat tgggttatct 780 atggtgcacc gctttgggaa gcggcatgac tccctcctgc ccatcattat ggccaacacc 840 tacttgcttg ttcctcctgt gctcaaccct attgtttatg gagtgaagac aaaggagatc 900 cggcagcgta tccttcgtct tttccatgtg accacccata cttcagatcc ctag 954

<210> 24 <211> 963 <212> DNA <213> Felis catus

<400> 24 atgccaaggt tcaccatggt ggtctggaat aacaataaca ccatggagcc tatatttatt 60 ctgaggggat ttcatggatt ggagtgtgtc tattcttgga tctcagtccc attctgtctt 120 gcatacttgg tagcatttat tggtaatgtt accatcctct ctgtcatttg gatagagtca 180 tcactccatc agcccatgta ctacttcctt tccatcttgg cactgactga cctaggtatg 240

Page 18

069269_0225_SL.TXT tctatgtcca cacttcccac catgcttgct gtgttatggc tggatgctcg ggagatccag 300 gcaagtgctt gctatgctca gctctttttc atccacacat tcacattcct ggagtcttcg 360 gtgctactgg ccatggcctt tgaccgtttt gttgctatct gccgtccact gcactatact 420 accatcctta acaacagtgt aataggcaag attggtttgg cctgcttgct aagaagcatg 480 ggagttgtac ttcctacacc tttgctactg agacattatc actactgcca tgacaatgcc 540 ctttcccata ccttctgttt gcaccaagac attctgaaat tatcctgttc agatgcaagg 600 atcagcagtg tctatggcct gtgtgtagtt attaccacac ttggtgtgga ttcagtctgc 660 atacttcttt cttatatcct gattctgaat gctgtgctgg ggattgcatc tcatgaagag 720 cggcggaagg cactcaacac atgcatatcc catatctgtg ttgtgctcat tttctttgtg 780 ccagtaattg gggtgtcaat ggtccatcgc tttgggaaac atctgtctcc aagaattcac 840 atcatcatgg ccgatattta cctgcttttc cccccagtgc ttaaccctat tgtctatagc 900 atcaaaacaa agcagattcg tctaagaatt ctccgcaggt ttggactgcg gagggggcat 960 taa 963 <210> 25 <211> 993 <212> DNA <213> Felis catus <400> 25 atgttcattg ttattcactc cttcgttact tctatttctc taacagcttt ggaatctcag 60 aacgcaacaa tgcattttgt gactgagttt gtcctcctgg gttttcctgg tcaaagggag 120 atgcagaact ttttcttctc attaatcctt gtggtctatc tcctcactct gctggggaat 180 ggggttattg tctatgtagt gaaatgggac aagcggcttc acacacccat gtacatcctc 240 ttgggaaact ttgccttcct agagatctgg tacatctcct ccactgtccc aaacatgctg 300 gtcaccatcc tctctgagac caagaccatc tccttcactg gatgcttcct ccaattttat 360 ttctttttct cattgggtac aacagagtgt ttcttcttat cagttatggc ttatgaccgg 420 taccttgcca tctgtcgccc actacattat ccttccatca tgactgggaa gctctgtgtg 480 atcctggtct gcgtttgctg ggtgagtgga tttctctgct atccaatccc cattgtcctc 540 atctcccaac ttcccttctg tggacctaac atcattgacc acttcgtgtg tgacccaggc 600

Page 19

069269_0225_SL.TXT ccattgttcg cactggcctg catccctgct ccttccactg aacttatctg ctataccttc 660 aactcagtga ttatctttgg gcccttcctt tctatcttgg gatcttacac tctggtactc 720 agagctgtgc ttcgtattcc ttctggtgct ggtcaaacta aagctttctc cacatgtggg 780 tcacacctaa tggtggtgtc tctattctat ggaaccctta tggtgatgta tgtaagccca 840 acatcaggaa atccagcagg aatgcagaag atcgtcactt tggtatactc agcagtgact 900 ccactcttaa acccccttat ctatagtctt cgaaataaag acatgaaaga tgccctaaag 960 aaactcctag gattaagaag taacccaaac tga 993 <210> 26 <211> 966 <212> DNA <213> Felis catus <400> 26 atggaggagg gtggtcccaa ccatggccag agcaaccaca ccaatgtgaa ggaatttgtc 60 ttcctagaac tcactcactt ccaggagctg gaatgtttct tgtttgtggc tttccttgct 120 gtatatgtaa ccaccgtgct gggcaatgcc ctcattgtgc tgaccatcac ctatgagtcc 180 caccttcaca ctcccatgta ctttctgctg cggaacaaat cggtcctgga cattgttttt 240 tcatctgtca ctgttcccaa gttcctggtg gatctgttat cagagaggaa aaccatctcc 300 tacaatggct gcatggcaca gatcttcttc ttccattttg ctggtggggc agatattttc 360 ttcctctccg tgatggccta tgacagatac cttgcaatcg ccaaacccct gcattatgtg 420 accattatga agagagaggt gtgggtgggc ttggtggtgg cttcctgggt gggcggtggt 480 ttgcactcaa ttgtccagat aattctgatg cttccactct ccttctgtgg ccccaacatc 540 ctggatgcct tctactgtga tgtgccccaa gtagttaagc tggcttgcac tgataccttt 600 gctctggaac ttctcatgat ctctaacaat gggttggtga ccctgctatg gttcctcttg 660 ctcctgggat cctacaccgt tattctggtg atgctgagat ctcactctgg ggcaggacgg 720 aacaaggccc tgtccacctg cacctcccat atcctcgtgg tgactctgca ctttgtgcct 780 tgtgtctaca tctactgccg gcccttcact acactgccca tggacacagc tgtgtccatc 840 aataacacgg tcattacgcc catgctgaac cccatgattt ataccctgag gaaccaggag 900

Page 20

069269_0225_SL.TXT atgaagtctg ccatgaaaag actacacaga aggcttggac cttctgagag cagtaagctg 960 gggtga 966 <210> 27 <211> 939 <212> DNA <213> Felis catus <400> 27 atggatgctc taaatcaaac aagagtgact gaatttgtct tcttgggact cactgataag 60 tgggtgctgg agatactatt ttttctggca ttctccgtca catatgtatt aacccttttg 120 ggaaacactc tcattatagt tactatagtc tttactccac gcctccatac ccccatgtat 180 ttcttcctga gcaatctgtc ctttattgac atctgccact catctgtcac tgtgcccaag 240 atgctagagg gcttgctttt agagataaag actatttcct ttgataattg cattgcacag 300 ctcttcttcc tacatctgtt tgcttgtgct gagatctttc tgctgaccat tatggcttat 360 gatcgttatg tagccatctg tgctccattg cactattcta atgtgatgaa catgagggtc 420 tgtgtacagc ttgtctttgc tctctggttg ggggctactg ttcactctct ggtgcagacc 480 ttcttgacca ttcgtctacc ttactgtggc cccaacatta ttgatagcta cttctgcgat 540 gtgccccctg tcatcaagct ggcttgcaca gatacatacc tcacgggaat gctaattgtg 600 tctaatagtg gaaccatctc cctcacctgt ttcctggctt tggtcacctc ttacacggtc 660 atcctggttt ctcttagaaa acagtcagct gaagggcgcc ggaaagcctt gtctacctgt 720 tcagcccact tcatggttgt agccttcttt tttggaccat gtatcttcat ctacactcgg 780 ccagacacta gcttctccat tgacaaggtg gtatctgtct tctacacagt ggtcactcct 840 ttgctgaatc ctctcattta caccttgaga aatgaggagg taaaaagtgc catgaagcat 900 ctcagacaga gaggtttttt catgaagtca ggtacatga 939 <210> 28 <211> 939 <212> DNA <213> Felis catus <400> 28 atggcagagg ccaacaacag cttttcagag ggctgcatcc tgatgggtat atctgaccat 60

Page 21

069269_0225_SL.TXT ccccagctgg agatcgtctt tttcatagtc attctcttct cttactcgct gaccctagtt 120 gggaattcga ccaccatcct gctctcctgc ctggatgccc ggctccacac ccccatgtac 180 ttcttcctca gcaacctctc ctccctggac ctcgctttta ctaccagctc ggtcccccaa 240 atgctgacca acttatgggg accagataag actataagct acgctggctg tgtgatccag 300 ctctatgttt tcctctggct aggggccact gagtgcatcc tgctcgtggt gatggcattc 360 gaccgccatg tggcagtttg ccagcccctg cgctacaccg tcatcgtgag ccctcggctc 420 tgccggctgc tggctgccat tgcatggctg ggcggcttga gcaactccat gatccagtca 480 acgttcactc tccagctccc attgtgtggg caccggaggg tggacaactt cctgtgtgag 540 gtgcctgcca tgatcaaact ggcctgtgga gacacaagtc tcaacgaggc cgtgctcaat 600 ggtgtctgca ccttcttcac tgccgtcccg ctgagcatca tcctgatctc ctactgctcc 660 atagctcggg cagtgctgaa gatccgctca gctgagggac agagaaaggc ctttaatact 720 tgcctttccc atctggtggt ggtgctcctc ttctatgggt cagctatcta cgggtacctc 780 cttccggcta agaccagcca ccagggccaa ggcaaattca tttccctctt ctactctgtg 840 gtcacgccaa tggtgaaccc tctcatctac actctgagaa acaaggaggt aaaggcggca 900 ctgaggaggc tccggggaaa gggaagagaa ttcggctga 939 <210> 29 <211> 957 <212> DNA <213> Felis catus <400> 29 atgagaagca tgtccacagc taaggcctgg aatagctctt cagtaaccat gttcatcttc 60 ctgggatttg cagaccatcc agaactccag acccttctct ttgtgacctt cctgggtatc 120 tatcttgtga cactggcctg gaacctggcc ctcatctttt tgatcagagg tgacccccgt 180 ctgcacacac ccatgtactt cttcctcagc aacttgtctt tcatcgacat ctgctactct 240 tctacagtgg cccccaagat gctcactgat ttcttctggg agcaaaagac catatcattc 300 ttgggctgtg ctgctcagtt ttttttcttt gtcagtatgg gtctcactga gtgcttcctc 360 ctgactgcca tggcatacga cagatacgca gccatctcca atcccctgct gtacacagcc 420 atcatgtccc aaggcctctg cacacgcatg gtgcttgggg catatgttgg tggcttcctg 480

Page 22

069269_0225_SL.TXT agctccctga tccaggccag ctccatattt cagcttcact tctgcggacc caacattatc 540 aatcatttct tctgtgacct ccctccagta ctggcacttt cttgctctga cacctttcct 600 agtcaagtgg tgaattttct cgtggtagtc actattgggg ggacatcatt cctcatcctc 660 atcatctcct acagttacat aggaactgct gtcttgaaaa tccgttcagt ggaaggccga 720 aagaaagcct tcagcacatg tgcctcacac ttgatggtgg tgactctgtt gtttgggacg 780 gcccttttca tgtacctgag acccagctcc agctactcgc ttggcaggga caaggtagtg 840 tctgtgttct attcactggt gatccccatg ctgaaccctc ttatttacag tttgaggaac 900 agagagatca aagatgccct atggaaggtg ttggagaaga agaaactgtt ttcctag 957 <210> 30 <211> 945 <212> DNA <213> Felis catus <400> 30

atgcctttaa tgagaatggc agctgagaac tcctctgtga cagaatttat ccttgcaggc 60 ttaaccaacc agcccggact tcggatgccc ctcttcttcc tgtttctagg tttctatgtg 120 gtcactgtga tggggaacct gggtctgata accctgattg ggctgaattc tcacctgcac 180 acccccatgt acttcttcct cttcaacttg tccttcatag atttttgcta ttccactgtt 240 atcactccca agatgctgat gagttttgtc tcaaagaaca ccatcgccta cgcagggtgt 300 atgactcagc tcttcttttt tcttttcttt gttgtctctg agtccttcat cctgtcagca 360 atggcatatg accgctacac cgccatctgt aacccactgg tgtacacagc caccatgtct 420 cctcaggtct gctcgcttct tctgttgggt gtctatgtga tggggtttgc tggggccatg 480 gcccacacga catgcatggt gaggctgacc ttctgtgcca acaatctggt tgaccactac 540 atgtgtgaca tccttcccct tcttgagcgc tcttgcacca gcacctatgt aaatgagctg 600 gtagttttcg ttgtcgtggg cattgatatt ggcgtgccca cagttaccat cttcatttct 660 tatgccctca tcctcaccag cattctccat attcgttcca ctgagggcag gtccaaagcc 720 ttcagcacat gcagctctca cataattgct gtttctcttt tctttgggtc aggggcattt 780 atgtacctca aaccatcctc tcttttacct atgaatcagg ggaaagtgtc ctccttgttc 840

Page 23

900

945

069269_0225_SL.TXT tataccaccg ttgtgcccat gctcaacccg ctaatctata gcttaagaaa taaagatgtc aaagttgctc tgaagaaatc attgagcaaa aagacattct cttga <210> 31 <211> 315 <212> PRT <213> Homo sapiens <400> 31

Met Gln Pro Glu Ser Gly Ala Asn Gly Thr Val Ile Ala Glu Phe Ile 1 5 10 15 Leu Leu Gly Leu Leu Glu Ala Pro Gly Leu Gln Pro Val Val Phe Val 20 25 30 Leu Phe Leu Phe Ala Tyr Leu Val Thr Val Arg Gly Asn Leu Ser Ile 35 40 45 Leu Ala Ala Val Leu Val Glu Pro Lys Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Val Leu Asp Val Gly Cys Ile Ser Val Thr 65 70 75 80 Val Pro Ser Met Leu Ser Arg Leu Leu Ser Arg Lys Arg Ala Val Pro 85 90 95 Cys Gly Ala Cys Leu Thr Gln Leu Phe Phe Phe His Leu Phe Val Gly 100 105 110 Val Asp Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Phe Leu Ala 115 120 125 Ile Cys Arg Pro Leu Thr Tyr Ser Thr Arg Met Ser Gln Thr Val Gln 130 135 140 Arg Met Leu Val Ala Ala Ser Trp Ala Cys Ala Phe Thr Asn Ala Leu 145 150 155 160 Thr His Thr Val Ala Met Ser Thr Leu Asn Phe Cys Gly Pro Asn Val

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165 170 175

Ile Asn His Phe Tyr Cys Asp Leu Pro Gln Leu Phe Gln Leu Ser Cys 180 185 190 Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe Ala Val Gly Phe Ile 195 200 205 Met Ala Gly Thr Pro Met Ala Leu Ile Val Ile Ser Tyr Ile His Val 210 215 220 Ala Ala Ala Val Leu Arg Ile Arg Ser Val Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ala Ile Phe Tyr Gly 245 250 255 Ser Gly Ile Phe Asn Tyr Met Arg Leu Gly Ser Thr Lys Leu Ser Asp 260 265 270 Lys Asp Lys Ala Val Gly Ile Phe Asn Thr Val Ile Asn Pro Met Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Phe Arg Asn Pro Asp Val Gln Ser Ala Ile 290 295 300 Trp Arg Met Leu Thr Gly Arg Arg Ser Leu Ala

305 310 315 <210> 32 <211> 317 <212> PRT <213> Homo sapiens

<400> 32 Met Arg Asn Leu Ser Gly Gly His Val Glu Glu Phe Val Leu Val Gly 1 5 10 15 Phe Pro Thr Thr Pro Pro Leu Gln Leu Leu Leu Phe Val Leu Phe Phe 20 25 30

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Ala Ile Tyr 35 Leu Leu Thr Leu Leu Glu Asn Ala Leu Ile Val Phe Thr 40 45 Ile Trp Leu Ala Pro Ser Leu His Arg Pro Met Tyr Phe Phe Leu Gly 50 55 60 His Leu Ser Phe Leu Glu Leu Trp Tyr Ile Asn Val Thr Ile Pro Arg 65 70 75 80 Leu Leu Ala Ala Phe Leu Thr Gln Asp Gly Arg Val Ser Tyr Val Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Ile Ala Leu Ala Cys Thr Glu Cys 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Gly 115 120 125 Pro Leu Leu Tyr Pro Ser Leu Met Pro Ser Ser Leu Ala Thr Arg Leu 130 135 140 Ala Ala Ala Ser Trp Gly Ser Gly Phe Phe Ser Ser Met Met Lys Leu 145 150 155 160 Leu Phe Ile Ser Gln Leu Ser Tyr Cys Gly Pro Asn Ile Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Leu Leu Asn Leu Thr Cys Ser Asp Lys 180 185 190 Glu Gln Ala Glu Leu Val Asp Phe Leu Leu Ala Leu Val Met Ile Leu 195 200 205 Leu Pro Leu Leu Ala Val Val Ser Ser Tyr Thr Ala Ile Ile Ala Ala 210 215 220 Ile Leu Arg Ile Pro Thr Ser Arg Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240

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Cys Ala Ala His Leu Ala Val Val Val Ile Tyr Tyr Ser Ser Thr Leu 245 250 255 Phe Thr Tyr Ala Arg Pro Arg Ala Met Tyr Thr Phe Asn His Asn Lys 260 265 270 Ile Ile Ser Val Leu Tyr Thr Ile Ile Val Pro Phe Phe Asn Pro Ala 275 280 285 Ile Tyr Cys Leu Arg Asn Lys Glu Val Lys Glu Ala Phe Arg Lys Thr 290 295 300 Val Met Gly Arg Cys His Tyr Pro Arg Asp Val Gln Asp

305 310 315 <210> 33 <211> 318 <212> PRT <213> Homo sapiens <400> 33

Met Met Val Asp Pro Asn Gly Asn Glu Ser Ser Ala Thr Tyr Phe Ile 1 5 10 15 Leu Ile Gly Leu Pro Gly Leu Glu Glu Ala Gln Phe Trp Leu Ala Phe 20 25 30 Pro Leu Cys Ser Leu Tyr Leu Ile Ala Val Leu Gly Asn Leu Thr Ile 35 40 45 Ile Tyr Ile Val Arg Thr Glu His Ser Leu His Glu Pro Met Tyr Ile 50 55 60 Phe Leu Cys Met Leu Ser Gly Ile Asp Ile Leu Ile Ser Thr Ser Ser 65 70 75 80 Met Pro Lys Met Leu Ala Ile Phe Trp Phe Asn Ser Thr Thr Ile Gln 85 90 95 Phe Asp Ala Cys Leu Leu Gln Met Phe Ala Ile His Ser Leu Ser Gly

Page 27

100

069269_0225_SL.TXT 105 110

Met Glu Ser 115 Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 120 125 Ile Cys His Pro Leu Arg His Ala Thr Val Leu Thr Leu Pro Arg Val 130 135 140 Thr Lys Ile Gly Val Ala Ala Val Val Arg Gly Ala Ala Leu Met Ala 145 150 155 160 Pro Leu Pro Val Phe Ile Lys Gln Leu Pro Phe Cys Arg Ser Asn Ile 165 170 175 Leu Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys 180 185 190 Asp Asp Ile Arg Val Asn Val Val Tyr Gly Leu Ile Val Ile Ile Ser 195 200 205 Ala Ile Gly Leu Asp Ser Leu Leu Ile Ser Phe Ser Tyr Leu Leu Ile 210 215 220 Leu Lys Thr Val Leu Gly Leu Thr Arg Glu Ala Gln Ala Lys Ala Phe 225 230 235 240 Gly Thr Cys Val Ser His Val Cys Ala Val Phe Ile Phe Tyr Val Pro 245 250 255 Phe Ile Gly Leu Ser Met Val His Arg Phe Ser Lys Arg Arg Asp Ser 260 265 270 Pro Leu Pro Val Ile Leu Ala Asn Ile Tyr Leu Leu Val Pro Pro Val 275 280 285 Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Glu Ile Arg Gln Arg 290 295 300 Ile Leu Arg Leu Phe His Val Ala Thr His Ala Ser Glu Pro

Page 28

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305 310 315 <210> 34 <211> 315 <212> PRT <213> Homo sapiens

<400> 34 Met 1 Gly Asp Trp Asn 5 Asn Ser Asp Ala Val Glu Pro Ile Phe Ile Leu 10 15 Arg Gly Phe Pro Gly Leu Glu Tyr Val His Ser Trp Leu Ser Ile Leu 20 25 30 Phe Cys Leu Ala Tyr Leu Val Ala Phe Met Gly Asn Val Thr Ile Leu 35 40 45 Ser Val Ile Trp Ile Glu Ser Ser Leu His Gln Pro Met Tyr Tyr Phe 50 55 60 Ile Ser Ile Leu Ala Val Asn Asp Leu Gly Met Ser Leu Ser Thr Leu 65 70 75 80 Pro Thr Met Leu Ala Val Leu Trp Leu Asp Ala Pro Glu Ile Gln Ala 85 90 95 Ser Ala Cys Tyr Ala Gln Leu Phe Phe Ile His Thr Phe Thr Phe Leu 100 105 110 Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Cys His Pro Leu His Tyr Pro Thr Ile Leu Thr Asn Ser Val Ile Gly 130 135 140 Lys Ile Gly Leu Ala Cys Leu Leu Arg Ser Leu Gly Val Val Leu Pro 145 150 155 160 Thr Pro Leu Leu Leu Arg His Tyr His Tyr Cys His Gly Asn Ala Leu 165 170 175

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Ser His Ala Phe Cys Leu His Gln Asp Val Leu Arg Leu Ser Cys Thr 180 185 190 Asp Ala Arg Thr Asn Ser Ile Tyr Gly Leu Cys Val Val Ile Ala Thr 195 200 205 Leu Gly Val Asp Ser Ile Phe Ile Leu Leu Ser Tyr Val Leu Ile Leu 210 215 220 Asn Thr Val Leu Asp Ile Ala Ser Arg Glu Glu Gln Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Val Ser His Ile Cys Val Val Leu Ile Phe Phe Val Pro 245 250 255 Val Ile Gly Val Ser Met Val His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Ile Val His Ile Leu Met Ala Asp Ile Tyr Leu Leu Leu Pro Pro Val 275 280 285 Leu Asn Pro Ile Val Tyr Ser Val Arg Thr Lys Gln Ile Arg Leu Gly 290 295 300 Ile Leu His Lys Phe Val Leu Arg Arg Arg Phe

305 310 315 <210> 35 <211> 330 <212> PRT <213> Homo sapiens <400> 35

Met Phe Phe Ile Ile His Ser Leu Val Thr Ser Val Phe Leu Thr Ala 1 5 10 15 Leu Gly Pro Gln Asn Arg Thr Met His Phe Val Thr Glu Phe Val Leu 20 25 30 Leu Gly Phe His Gly Gln Arg Glu Met Gln Ser Cys Phe Phe Ser Phe

Page 30

069269_0225_SL.TXT 40 45

Ile Leu Val Leu Tyr Leu Leu Thr Leu Leu Gly Asn Gly Ala Ile Val 50 55 60 Cys Ala Val Lys Leu Asp Arg Arg Leu His Thr Pro Met Tyr Ile Leu 65 70 75 80 Leu Gly Asn Phe Ala Phe Leu Glu Ile Trp Tyr Ile Ser Ser Thr Val 85 90 95 Pro Asn Met Leu Val Asn Ile Leu Ser Glu Ile Lys Thr Ile Ser Phe 100 105 110 Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr 115 120 125 Glu Cys Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile 130 135 140 Cys Arg Pro Leu His Tyr Pro Ser Ile Met Thr Gly Lys Phe Cys Ile 145 150 155 160 Ile Leu Val Cys Val Cys Trp Val Gly Gly Phe Leu Cys Tyr Pro Val 165 170 175 Pro Ile Val Leu Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn Ile Ile 180 185 190 Asp His Leu Val Cys Asp Pro Gly Pro Leu Phe Ala Leu Ala Cys Ile 195 200 205 Ser Ala Pro Ser Thr Glu Leu Ile Cys Tyr Thr Phe Asn Ser Met Ile 210 215 220 Ile Phe Gly Pro Phe Leu Ser Ile Leu Gly Ser Tyr Thr Leu Val Ile 225 230 235 240 Arg Ala Val Leu Cys Ile Pro Ser Gly Ala Gly Arg Thr Lys Ala Phe

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245 250 255 Ser Thr Cys Gly Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr 260 265 270 Leu Met Val Met Tyr Val Ser Pro Thr Ser Gly Asn Pro Ala Gly Met 275 280 285 Gln Lys Ile Ile Thr Leu Val Tyr Thr Ala Met Thr Pro Phe Leu Asn 290 295 300 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys 305 310 315 320 Arg Val Leu Gly Leu Thr Val Ser Gln Asn

325 330 <210> 36 <211> 314 <212> PRT <213> Homo sapiens

<400> 36 Asn His 5 Thr Asn Val Lys Glu Phe Phe Phe Leu Glu Met Asp 1 Gln Ile 10 15 Leu Thr Arg Ser Arg Glu Leu Glu Phe Phe Leu Phe Val Val Phe Phe 20 25 30 Ala Val Tyr Val Ala Thr Val Leu Gly Asn Ala Leu Ile Val Val Thr 35 40 45 Ile Thr Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Lys Ser Val Leu Asp Ile Val Phe Ser Ser Ile Thr Val Pro Lys 65 70 75 80 Phe Leu Val Asp Leu Leu Ser Asp Arg Lys Thr Ile Ser Tyr Asn Gly 85 90 95

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Cys Met Ala Gln 100 Ile Phe Phe Phe His Phe Ala Gly Gly Ala Asp Ile 105 110 Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Ala Lys 115 120 125 Pro Leu His Tyr Val Thr Met Met Arg Lys Glu Val Trp Val Ala Leu 130 135 140 Val Val Ala Ser Trp Val Ser Gly Gly Leu His Ser Ile Ile Gln Val 145 150 155 160 Ile Leu Met Leu Pro Phe Pro Phe Cys Gly Pro Asn Thr Leu Asp Ala 165 170 175 Phe Tyr Cys Tyr Val Leu Gln Val Val Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Ala Leu Glu Leu Phe Met Ile Ser Asn Asn Gly Leu Val Thr Leu 195 200 205 Leu Trp Phe Leu Leu Leu Leu Gly Ser Tyr Thr Val Ile Leu Val Met 210 215 220 Leu Arg Ser His Ser Gly Glu Gly Arg Asn Lys Ala Leu Ser Thr Cys 225 230 235 240 Thr Ser His Met Leu Val Val Thr Leu His Phe Val Pro Cys Val Tyr 245 250 255 Ile Tyr Cys Arg Pro Phe Met Thr Leu Pro Met Asp Thr Thr Ile Ser 260 265 270 Ile Asn Asn Thr Val Ile Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser 275 280 285 Leu Arg Asn Gln Glu Met Lys Ser Ala Met Gln Arg Leu Gln Arg Arg 290 295 300

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Leu Gly Pro Ser Glu Ser Arg Lys Trp Gly 305 310 <210> 37 <211> 313 <212> PRT <213> Homo sapiens

<400> 37 Met Asp 1 Ser Leu Asn Gln Thr Arg Val Thr Glu Phe Val Phe Leu 15 Gly 5 10 Leu Thr Asp Asn Arg Val Leu Glu Met Leu Phe Phe Met Ala Phe Ser 20 25 30 Ala Ile Tyr Met Leu Thr Leu Ser Gly Asn Ile Leu Ile Ile Ile Ala 35 40 45 Thr Val Phe Thr Pro Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Ile Cys His Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Gly Leu Leu Leu Glu Arg Lys Thr Ile Ser Phe Asp Asn 85 90 95 Cys Ile Thr Gln Leu Phe Phe Leu His Leu Phe Ala Cys Ala Glu Ile 100 105 110 Phe Leu Leu Ile Ile Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Thr 115 120 125 Pro Leu His Tyr Pro Asn Val Met Asn Met Arg Val Cys Ile Gln Leu 130 135 140 Val Phe Ala Leu Trp Leu Gly Gly Thr Val His Ser Leu Gly Gln Thr 145 150 155 160 Phe Leu Thr Ile Arg Leu Pro Tyr Cys Gly Pro Asn Ile Ile Asp Ser

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165 170 175 Tyr Phe Cys Asp Val Pro Leu Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Tyr Leu Thr Gly Ile Leu Ile Val Thr Asn Ser Gly Thr Ile Ser Leu 195 200 205 Ser Cys Phe Leu Ala Val Val Thr Ser Tyr Met Val Ile Leu Val Ser 210 215 220 Leu Arg Lys His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys 225 230 235 240 Ser Ala His Phe Met Val Val Ala Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Thr Arg Pro Asp Thr Ser Phe Ser Ile Asp Lys Val Val Ser 260 265 270 Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Glu Glu Val Lys Ser Ala Met Lys Gln Leu Arg Gln Arg 290 295 300 Gln Val Phe Phe Thr Lys Ser Tyr Thr

305 310 <210> 38 <211> 312 <212> PRT <213> Homo sapiens <400> 38

Met Asp Gly Val Asn Asp Ser Ser Leu Gln Gly Phe Val Leu Met Gly 1 5 10 15

Ile Ser Asp His Pro Gln Leu Glu Met Ile Phe Phe Ile Ala Ile Leu 20 25 30

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Phe Ser Tyr 35 Leu Leu Thr Leu Leu Gly Asn Ser Thr Ile Ile Leu Leu 40 45 Ser Arg Leu Glu Ala Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Ser Leu Asp Leu Ala Phe Ala Thr Ser Ser Val Pro Gln 65 70 75 80 Met Leu Ile Asn Leu Trp Gly Pro Gly Lys Thr Ile Ser Tyr Gly Gly 85 90 95 Cys Ile Thr Gln Leu Tyr Val Phe Leu Trp Leu Gly Ala Thr Glu Cys 100 105 110 Ile Leu Leu Val Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Arg 115 120 125 Pro Leu Arg Tyr Thr Ala Ile Met Asn Pro Gln Leu Cys Trp Leu Leu 130 135 140 Ala Val Ile Ala Trp Leu Gly Gly Leu Gly Asn Ser Val Ile Gln Ser 145 150 155 160 Thr Phe Thr Leu Gln Leu Pro Leu Cys Gly His Arg Arg Val Glu Gly 165 170 175 Phe Leu Cys Glu Val Pro Ala Met Ile Lys Leu Ala Cys Gly Asp Thr 180 185 190 Ser Leu Asn Gln Ala Val Leu Asn Gly Val Cys Thr Phe Phe Thr Ala 195 200 205 Val Pro Leu Ser Ile Ile Val Ile Ser Tyr Cys Leu Ile Ala Gln Ala 210 215 220 Val Leu Lys Ile Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe Asn Thr 225 230 235 240

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Cys Leu Ser His Leu Leu Val Val Phe Leu Phe Tyr Gly Ser Ala Ser 245 250 255 Tyr Gly Tyr Leu Leu Pro Ala Lys Asn Ser Lys Gln Asp Gln Gly Lys 260 265 270 Phe Ile Ser Leu Phe Tyr Ser Leu Val Thr Pro Met Val Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Met Glu Val Lys Gly Ala Leu Arg Arg Leu 290 295 300 Leu Gly Lys Gly Arg Glu Val Gly

305 310 <210> 39 <211> 315 <212> PRT <213> Homo sapiens <400> 39

Met Ser Ile Thr Lys Ala Trp Asn Ser Ser Ser Val Thr Met Phe Ile 1 5 10 15 Leu Leu Gly Phe Thr Asp His Pro Glu Leu Gln Ala Leu Leu Phe Val 20 25 30 Thr Phe Leu Gly Ile Tyr Leu Thr Thr Leu Ala Trp Asn Leu Ala Leu 35 40 45 Ile Phe Leu Ile Arg Gly Asp Thr His Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Ser Asn Leu Ser Phe Ile Asp Ile Cys Tyr Ser Ser Ala Val 65 70 75 80 Ala Pro Asn Met Leu Thr Asp Phe Phe Trp Glu Gln Lys Thr Ile Ser 85 90 95 Phe Val Gly Cys Ala Ala Gln Phe Phe Phe Phe Val Gly Met Gly Leu

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100

069269_0225_SL.TXT 105 110

Ser Glu Cys 115 Leu Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala 120 125 Ile Ser Ser Pro Leu Leu Tyr Pro Thr Ile Met Thr Gln Gly Leu Cys 130 135 140 Thr Arg Met Val Val Gly Ala Tyr Val Gly Gly Phe Leu Ser Ser Leu 145 150 155 160 Ile Gln Ala Ser Ser Ile Phe Arg Leu His Phe Cys Gly Pro Asn Ile 165 170 175 Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Ala Leu Ser Cys 180 185 190 Ser Asp Thr Phe Leu Ser Gln Val Val Asn Phe Leu Val Val Val Thr 195 200 205 Val Gly Gly Thr Ser Phe Leu Gln Leu Leu Ile Ser Tyr Gly Tyr Ile 210 215 220 Val Ser Ala Val Leu Lys Ile Pro Ser Ala Glu Gly Arg Trp Lys Ala 225 230 235 240 Cys Asn Thr Cys Ala Ser His Leu Met Val Val Thr Leu Leu Phe Gly 245 250 255 Thr Ala Leu Phe Val Tyr Leu Arg Pro Ser Ser Ser Tyr Leu Leu Gly 260 265 270 Arg Asp Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu 290 295 300 Trp Lys Val Leu Glu Arg Lys Lys Val Phe Ser

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305 310 315 <210> 40 <211> 311 <212> PRT <213> Homo sapiens

<400> 40 Met 1 Ala Ala Glu Asn 5 Ser Ser Phe Val Thr 10 Gln Phe Ile Leu Ala 15 Gly Leu Thr Asp Gln Pro Gly Val Gln Ile Pro Leu Phe Phe Leu Phe Leu 20 25 30 Gly Phe Tyr Val Val Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Ile Arg Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Tyr 50 55 60 Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 Met Leu Met Ser Phe Val Leu Lys Lys Asn Ser Ile Ser Tyr Ala Gly 85 90 95 Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val Val Ser Glu Ser 100 105 110 Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Val Thr Met Ser Pro Gln Val Cys Phe Leu Leu 130 135 140 Leu Leu Gly Val Tyr Gly Met Gly Phe Ala Gly Ala Met Ala His Thr 145 150 155 160 Ala Cys Met Met Gly Val Thr Phe Cys Ala Asn Asn Leu Val Asn His 165 170 175

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Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Cys Ala Cys Thr Ser Thr 180 185 190 Tyr Val Asn Glu Leu Val Val Phe Val Val Val Gly Ile Asp Ile Gly 195 200 205 Val Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu Ile Leu Ser Ser 210 215 220 Ile Phe His Ile Asp Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu Lys Pro Phe Ser Leu Leu Ala Met Asn Gln Gly Lys 260 265 270 Val Ser Ser Leu Phe Tyr Thr Thr Val Val Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Lys Lys Ile 290 295 300 Leu Asn Lys Asn Ala Phe Ser

305 310 <210> 41 <211> 315 <212> PRT

<213> Canis familiaris <400> 41 Met Gln Ser Lys Phe Gly Ala Asn Ser Thr Ala Ile Thr Glu Phe Ile 1 5 10 15 Leu Leu Gly Leu Val Asp Thr Pro Gly Leu Gln Pro Val Val Phe Val 20 25 30 Val Phe Leu Phe Ala Tyr Leu Val Thr Val Gly Gly Asn Leu Ser Ile

Page 40

069269_0225_SL.TXT 40 45

Leu Ala Ala Ile Leu Val Glu Pro Lys Leu His Thr 60 Pro Met Tyr Phe 50 55 Phe Leu Gly Asn Leu Ser Val Leu Asp Val Gly Cys Ile Thr Val Thr 65 70 75 80 Val Pro Ser Met Leu Ala Arg Leu Leu Ser His Lys Arg Thr Val Pro 85 90 95 Tyr Arg Ala Cys Leu Thr Gln Leu Phe Phe Phe His Leu Leu Val Gly 100 105 110 Val Asp Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Phe Leu Ala 115 120 125 Ile Cys Arg Pro Leu Thr Tyr Ser Thr Gln Met Ser Gln Thr Val Gln 130 135 140 Arg Ile Leu Val Val Val Ser Trp Ala Leu Ala Phe Thr Asn Ala Leu 145 150 155 160 Thr His Thr Val Ala Ile Ala Thr Leu Asn Phe Cys Gly Pro Asn Val 165 170 175 Ile Asn His Phe Tyr Cys Asp Leu Pro Gln Leu Phe Gln Leu Ser Cys 180 185 190 Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe Ala Val Gly Phe Ile 195 200 205 Met Ala Gly Thr Pro Leu Ala Leu Ile Ile Thr Ser Tyr Ala His Val 210 215 220 Ala Ala Ala Val Leu Arg Ile Arg Ser Ala Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ala Ile Phe Tyr Gly

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245 250 255 Ser Gly Ile Phe Asn Tyr Met Arg Leu Gly Thr Ala Lys His Ser Asp 260 265 270 Lys Asp Lys Gly Val Gly Val Phe Asn Thr Val Ile Asn Pro Met Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Leu Asp Val Gln Gly Ala Leu 290 295 300 Trp Arg Val Leu Arg Gly Arg Gln Ser Leu Ala

305 310 315 <210> 42 <211> 318 <212> PRT <213> Canis familiaris <400> 42

Met Met Gly Asn Leu Ser Gly Gly His Ile Ala Asp Phe Ile Leu Val 1 5 10 15

Gly Phe Pro Thr Ser Pro Pro Leu Gln Leu Leu Leu Phe Val Leu Phe 20 25 30

Phe Ala Ile Tyr Leu Leu Thr Leu Leu Glu Asn Ala Leu Ile Val Ser 35 40 45

Thr Ile Trp Leu Thr Pro Ser Leu His Arg Pro Met Tyr Phe Phe Leu 50 55 60

Gly His Leu Ser Phe Leu Glu Leu Trp Tyr Ile Asn Val Thr Val Pro 65 70 75 80

Arg Leu Leu Gly Ala Phe Leu Thr Gln Asp Arg Arg Val Ser Tyr Val 85 90 95

Gly Cys Met Thr Gln Leu Tyr Phe Phe Ile Ala Leu Ala Cys Thr Glu 100 105 110

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Cys Val Leu 115 Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys 120 125 Glu Pro Leu Arg Tyr Pro Ser Leu Met Pro Ser Ser Leu Ala Ile Arg 130 135 140 Leu Ala Ala Ser Ser Trp Gly Gly Gly Phe Phe Ser Ser Met Met Lys 145 150 155 160 Leu Leu Phe Ile Ser Arg Leu Ser Tyr Cys Gly Pro Asn Ile Ile Asn 165 170 175 His Phe Phe Cys Asp Ile Ser Pro Leu Leu Asn Leu Thr Cys Ser Asp 180 185 190 Lys Glu Gln Ala Glu Leu Val Asp Phe Leu Leu Ala Leu Val Met Ile 195 200 205 Leu Leu Pro Leu Leu Ala Val Val Ser Ser Tyr Ala Ala Ile Ile Ala 210 215 220 Thr Ile Leu Arg Ile Pro Thr Ala Gln Gly Arg Arg Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Ala Val Val Val Ile Tyr Tyr Ser Ser Thr 245 250 255 Leu Phe Thr Tyr Ala Arg Pro Arg Ala Met Tyr Thr Phe Asn His Asn 260 265 270 Lys Ile Ile Ser Val Leu Tyr Thr Val Ile Val Pro Phe Leu Asn Pro 275 280 285 Ala Ile Tyr Cys Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Arg Lys 290 295 300 Leu Val Leu Gly Arg Cys His Tyr Pro Ser Asp Val Pro Asp

305 310 315

Page 43

069269_0225_SL.TXT <210> 43 <211> 317 <212> PRT <213> Canis familiaris <400> 43

Met 1 Val Asp Pro Asn Gly Asn Glu Ser Ser Ala Thr Tyr Phe Ile Leu 5 10 15 Ile Gly Leu Pro Gly Leu Glu Glu Ala Gln Phe Trp Leu Ala Phe Pro 20 25 30 Leu Cys Ser Leu Tyr Phe Ile Ala Val Leu Gly Asn Leu Thr Ile Ile 35 40 45 Tyr Ile Val Arg Thr Glu His Ser Leu His Glu Pro Met Tyr Val Phe 50 55 60 Leu Cys Met Leu Ser Gly Leu Asp Ile Leu Ile Ser Thr Ser Ser Met 65 70 75 80 Pro Lys Met Met Ala Ile Phe Trp Phe Asn Ser Thr Thr Ile Gln Phe 85 90 95 Asp Ala Cys Leu Leu Gln Met Phe Ala Ile His Ser Leu Ser Gly Met 100 105 110 Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg His Ala Thr Val Leu Thr Leu Pro Arg Val Met 130 135 140 Lys Ile Gly Met Ala Ala Val Val Arg Gly Thr Ala Leu Met Ala Pro 145 150 155 160 Leu Pro Val Phe Ile Lys Arg Leu Pro Phe Cys His Ser Asn Ile Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ala

Page 44

180

069269_0225_SL.TXT 185 190

Asp Ile Arg Val Asn Ile Ile Tyr Gly Leu Ile Val Ile Ile Ser Ala 195 200 205 Ile Gly Leu Asp Ser Leu Leu Ile Ser Leu Ser Tyr Leu Leu Ile Leu 210 215 220 Lys Thr Val Leu Gly Leu Thr Arg Glu Ala Gln Ala Lys Ala Phe Gly 225 230 235 240 Thr Cys Val Ser His Val Cys Ala Val Phe Ile Phe Tyr Val Pro Phe 245 250 255 Ile Gly Leu Ser Met Val His Arg Phe Gly Lys Arg His Asp Ser Phe 260 265 270 Leu Pro Ile Ile Met Ala Asn Thr Tyr Leu Leu Val Pro Pro Val Leu 275 280 285 Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Glu Ile Trp Gln Arg Ile 290 295 300 Leu Arg Leu Phe His Val Thr Asn His Thr Ser Asp Leu

305 310 315 <210> 44 <211> 320 <212> PRT <213> Canis familiaris <400> 44

Met Pro Arg Val Thr Met Val Val Trp Asn Asn Asn Asn Thr Leu Glu 1 5 10 15

Pro Ile Phe Ile Leu Lys Gly Phe Pro Gly Leu Glu Cys Val His Ser 20 25 30

Trp Phe Ser Ile Pro Phe Cys Leu Ala Tyr Leu Val Ala Phe Ile Gly 35 40 45

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Asn Val 50 Thr Ile Leu Ser Val Ile 55 Trp Ile Glu Ser Ser Leu His 60 Gln Pro Met Tyr Tyr Phe Leu Ser Ile Leu Ala Leu Thr Asp Leu Gly Met 65 70 75 80 Ser Met Ser Thr Leu Pro Thr Met Leu Ala Val Leu Trp Leu Asp Ala 85 90 95 Arg Glu Ile Gln Ala Ser Ala Cys Tyr Ala Gln Leu Phe Phe Ile His 100 105 110 Thr Phe Thr Phe Leu Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp 115 120 125 Arg Phe Val Ala Ile Cys Arg Pro Leu His Tyr Thr Thr Ile Leu Asn 130 135 140 Asn Ser Val Ile Gly Lys Ile Gly Leu Ala Cys Leu Leu Arg Ser Met 145 150 155 160 Gly Val Val Leu Pro Thr Pro Leu Leu Leu Arg His Tyr His Tyr Cys 165 170 175 His Val Asn Ala Leu Ser His Ala Phe Cys Leu His Gln Asp Val Leu 180 185 190 Lys Leu Ser Cys Ser Asp Ala Arg Ile Ser Ser Val Tyr Gly Leu Cys 195 200 205 Val Val Ile Thr Thr Leu Gly Met Asp Ser Val Phe Ile Leu Leu Ser 210 215 220 Tyr Val Leu Ile Leu Asn Ala Val Leu Gly Ile Ala Ser His Glu Glu 225 230 235 240 Arg Leu Lys Ala Leu Asn Thr Cys Val Ser His Ile Cys Val Val Leu 245 250 255

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Ile Phe Phe Val Pro Val Ile Gly Val 265 Ser Met Val His Arg 270 Phe Gly 260 Lys His Leu Ser Pro Ile Val His Ile Ile Met Ala Asp Ile Tyr Leu 275 280 285 Leu Phe Pro Pro Val Leu Asn Pro Ile Val Tyr Ser Val Arg Thr Lys 290 295 300 Gln Ile Arg Ile Arg Ile Phe His Lys Leu Arg Leu Gly Arg Arg Leu 305 310 315 320

<210> 45 <211> 330 <212> PRT

<213> Canis familiaris <400> 45 Met Leu Ile Ile Ile His Ser Leu Val Ile Ser Ala Ser Leu Thr Ala 1 5 10 15 Leu Glu Ser Gln Asn Thr Thr Met Arg Phe Val Ser Glu Phe Val Leu 20 25 30 Leu Gly Phe Pro Gly Gln Arg Glu Met Gln Asn Phe Phe Phe Ser Phe 35 40 45 Ile Leu Val Ile Tyr Leu Leu Thr Leu Leu Gly Asn Gly Ile Ile Val 50 55 60 Cys Ile Val Lys Trp Asp Lys Gln Leu His Thr Pro Met Tyr Ile Phe 65 70 75 80 Leu Gly Asn Phe Ala Phe Leu Glu Ile Trp Tyr Thr Ser Ser Thr Val 85 90 95 Pro Ser Met Leu Val Asn Ile Leu Ser Glu Thr Lys Thr Ile Ser Phe 100 105 110 Thr Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr

Page 47

115 069269_0225_SL.TXT 120 125 Glu Cys Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile 130 135 140 Cys Arg Pro Leu His Tyr Pro Ser Ile Met Thr Gly Lys Leu Cys Val 145 150 155 160 Ala Leu Val Cys Val Cys Trp Val Ser Gly Phe Leu Cys Tyr Pro Val 165 170 175 Pro Ile Val Leu Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn Ile Ile 180 185 190 Asp His Phe Val Cys Asp Pro Gly Pro Leu Phe Ala Leu Ala Cys Ile 195 200 205 Pro Ala Pro Ser Thr Glu Leu Leu Cys Tyr Thr Phe Asn Ser Leu Ile 210 215 220 Ile Phe Gly Pro Phe Leu Phe Ile Leu Gly Ser Tyr Thr Leu Val Leu 225 230 235 240 Arg Ala Val Leu Arg Ile Pro Ser Gly Ala Gly Arg Thr Lys Ala Phe 245 250 255 Ser Thr Cys Gly Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr 260 265 270 Leu Met Val Met Tyr Val Ser Pro Thr Ser Gly Asn Pro Thr Gly Met 275 280 285 Gln Lys Ile Ile Thr Leu Val Tyr Ser Ala Val Thr Pro Leu Leu Asn 290 295 300 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys 305 310 315 320

Lys Val Leu Gly Leu Arg Ser Asn Gln Asn

Page 48

069269_0225_SL.TXT 325 330 <210> 46 <211> 311 <212> PRT <213> Canis familiaris <400> 46

Met 1 Gly Gln Ser Asn 5 His Thr Asn Val Lys Glu Phe Val Phe Leu Lys 10 15 Leu Thr His Phe His Glu Leu Glu Leu Phe Leu Phe Val Val Phe Leu 20 25 30 Ala Val Tyr Val Ala Thr Val Leu Gly Asn Val Leu Ile Val Val Thr 35 40 45 Ile Thr Cys Glu Ser His Leu His Ser Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Lys Ser Val Leu Asp Ile Val Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Phe Leu Val Asp Leu Leu Ser Glu Arg Lys Thr Ile Ser Tyr Asn Gly 85 90 95 Cys Met Ala Gln Ile Phe Phe Phe His Phe Ala Gly Gly Ala Asp Ile 100 105 110 Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Ala Lys 115 120 125 Pro Leu His Tyr Val Thr Ile Met Arg Arg Glu Thr Trp Val Gly Leu 130 135 140 Val Val Ala Ser Trp Val Gly Gly Gly Leu His Ser Ile Val Gln Val 145 150 155 160 Thr Leu Met Leu Pro Leu Pro Phe Cys Gly Pro Asn Ile Leu Asp Ala 165 170 175

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Phe Tyr Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr 190 Asn Thr 180 185 Phe Ala Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Val Thr Leu 195 200 205 Leu Trp Phe Leu Leu Leu Leu Gly Ser Tyr Thr Val Ile Leu Val Met 210 215 220 Leu Arg Ser His Ser Gly Glu Gly Arg Asn Lys Ala Leu Ser Thr Cys 225 230 235 240 Thr Ser His Ile Phe Val Val Thr Leu His Phe Val Pro Cys Val Tyr 245 250 255 Ile Tyr Cys Arg Pro Phe Ile Thr Leu Pro Met Asp Thr Val Val Ser 260 265 270 Ile Asn Asn Thr Val Ile Thr Pro Met Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Lys Ser Ala Met Lys Arg Leu Gln Arg Arg 290 295 300 Leu Gly Pro Ser Glu Ser Ser

305 310 <210> 47 <211> 308 <212> PRT

<213> Canis familiaris <400> 47 Met Glu Ala Pro Asn Gln Thr Arg Val Thr Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Thr Asp Asn Trp Ala Leu Gly Thr Leu Leu Phe Val Ala Phe Ser 20 25 30 Leu Ala Tyr Val Leu Thr Leu Leu Gly Asn Thr Leu Ile Ile Val Thr

Page 50

069269_0225_SL.TXT 40 45

Thr Ala Leu Thr Arg Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Thr Cys His Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Gly Leu Leu Arg Glu Arg Lys Thr Ile Ser Phe Asp Asp 85 90 95 Cys Ile Ala Gln Leu Phe Phe Leu His Leu Phe Ala Cys Ala Glu Ile 100 105 110 Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ala 115 120 125 Pro Leu Arg Tyr Pro Asn Val Met Ser Ile Arg Val Cys Val Gln Leu 130 135 140 Val Leu Ala Leu Trp Trp Gly Gly Thr Val His Ser Leu Val Gln Thr 145 150 155 160 Leu Leu Thr Ile Arg Leu Pro Tyr Cys Gly Pro Asn Val Ile Asp Ser 165 170 175 Tyr Phe Cys Asp Val Pro Pro Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Tyr Leu Thr Gly Val Leu Ile Val Ser Asn Ser Gly Thr Ile Ser Leu 195 200 205 Thr Cys Phe Leu Ala Leu Val Thr Ser Tyr Thr Ile Ile Leu Val Ser 210 215 220 Leu Arg Lys Gln Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys 225 230 235 240 Ser Ala His Phe Met Val Val Ala Phe Phe Phe Gly Pro Cys Ile Phe

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245 250 255 Ile Tyr Thr Arg Pro Asp Thr Ser Phe Ser Ile Asp Lys Val Val Ser 260 265 270 Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr 275 280 285 Leu Arg Asn Glu Glu Val Lys Ser Ala Ile Lys His Leu Arg Gln Lys 290 295 300 Gln Val Phe Ser 305 <210> 48 <211> 312 <212> PRT <213> Canis familiaris <400> 48 Met Pro Glu Ala Asn Asp Ser Phe Leu Glu Gly Phe Ile Leu Met Gly 1 5 10 15 Ile Ser Asp His Pro Gln Leu Glu Ile Ile Phe Phe Met Val Ile Leu 20 25 30 Phe Ser Tyr Leu Leu Thr Leu Leu Gly Asn Ser Thr Ile Ile Leu Leu 35 40 45 Ser Trp Leu Asp Ala Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Thr Leu Asp Leu Ala Phe Thr Thr Ser Ser Val Pro Gln 65 70 75 80 Met Leu Ile Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Gly Gly 85 90 95 Cys Val Thr Gln Leu Tyr Val Phe Leu Trp Leu Gly Ala Thr Glu Cys 100 105 110

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Ile Leu Leu 115 Val Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Arg 120 125 Pro Leu His Tyr Thr Thr Ile Met Asn Pro Arg Leu Cys Trp Leu Leu 130 135 140 Ala Ala Ile Ala Trp Leu Gly Gly Leu Ser Asn Ser Val Ile Gln Ser 145 150 155 160 Thr Phe Thr Leu Gln Leu Pro Leu Cys Gly His Arg Arg Val Asp Asn 165 170 175 Phe Leu Cys Glu Val Pro Ala Met Ile Lys Leu Ala Cys Gly Asp Thr 180 185 190 Ser Leu Asn Glu Val Val Leu Asn Gly Val Cys Thr Phe Phe Thr Ala 195 200 205 Val Pro Leu Ser Val Ile Leu Ile Ser Tyr Cys Tyr Ile Ala Gln Ala 210 215 220 Val Leu Lys Ile His Ser Val Glu Gly Gln Arg Lys Ala Phe Asn Thr 225 230 235 240 Cys Leu Ser His Leu Val Val Val Leu Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Tyr Gly Tyr Leu Leu Pro Ala Lys Thr Ser Asn Gln Asp Gln Gly Lys 260 265 270 Phe Ile Ser Leu Phe Tyr Ser Val Val Thr Pro Thr Val Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Arg Glu Val Lys Gly Ala Leu Arg Arg Leu 290 295 300 Leu Gly Lys Gly Arg Ser Leu Gly

305 310

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069269_0225_SL.TXT <210> 49 <211> 319 <212> PRT <213> Canis familiaris <400> 49

Met 1 Ser Thr Val Lys Ala Trp Asn Ser Ser Ser Val Thr Met Phe Ile 5 10 15 Leu Leu Gly Phe Ala Asp His Pro Glu Leu Gln Thr Leu Leu Phe Val 20 25 30 Thr Phe Leu Ser Ile Tyr Leu Val Thr Leu Ala Trp Asn Leu Ala Leu 35 40 45 Ile Phe Leu Ile Arg Ser Asp Pro His Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Ser Asn Leu Ser Phe Ile Asp Ile Cys Tyr Ser Ser Thr Val 65 70 75 80 Ala Pro Lys Met Leu Thr Asp Phe Phe Gln Glu Gln Lys Thr Ile Ser 85 90 95 Phe Leu Gly Cys Ala Ala Gln Phe Phe Phe Phe Val Ser Met Gly Leu 100 105 110 Thr Glu Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala 115 120 125 Ile Ser Asn Pro Leu Leu Tyr Thr Ala Ile Met Ser Gln Gly Leu Cys 130 135 140 Thr Arg Met Val Leu Gly Ala Tyr Val Gly Gly Phe Leu Ser Ser Leu 145 150 155 160 Ile Gln Ala Ile Ser Ile Phe Gln Leu His Phe Cys Gly Pro Asn Ile 165 170 175 Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Ala Leu Ser Cys

Page 54

180

069269_0225_SL.TXT 185 190

Ser Asp Thr Phe Pro Ser Gln Val Val Asn Phe Leu Ile Val Ile Thr 195 200 205 Val Gly Gly Thr Ser Phe Leu Ile Leu Leu Ile Ser Tyr Ser Tyr Ile 210 215 220 Gly Ala Ala Val Leu Lys Ile Arg Ser Val Glu Gly Arg Arg Lys Ala 225 230 235 240 Phe Asn Thr Cys Ala Ser His Leu Met Val Val Thr Leu Leu Phe Gly 245 250 255 Thr Ala Leu Phe Met Tyr Leu Arg Pro Ser Ser Ser Tyr Ser Leu Ala 260 265 270 Arg Asp Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Asp Ala Leu 290 295 300 Trp Lys Ala Leu Glu Lys Lys Lys Val Phe Phe Leu Asp His Asp

305 310 315 <210> 50 <211> 315 <212> PRT <213> Canis familiaris <400> 50

Met Pro Leu Val Arg Met Ala Ala Glu Asn Ser Ser Val Thr Glu Phe 1 5 10 15

Ile Leu Ser Gly Leu Thr Asn Gln Pro Gly Leu Gln Ile Pro Leu Phe 20 25 30

Phe Leu Phe Leu Gly Phe Tyr Val Val Thr Val Val Gly Asn Leu Gly 35 40 45

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Leu Ile Thr Leu Ile Gly Leu Asn 55 Ser His Leu His 60 Thr Pro Met Tyr 50 Phe Phe Leu Phe Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Thr Val 65 70 75 80 Ile Thr Pro Lys Met Leu Met Asn Phe Val Leu Arg Lys Asn Val Ile 85 90 95 Ser Tyr Ala Gly Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val 100 105 110 Val Ser Glu Ser Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Ala 115 120 125 Ala Ile Cys Asn Pro Leu Val Tyr Thr Ala Thr Met Ser Pro Gln Val 130 135 140 Cys Phe Leu Leu Leu Leu Gly Val Tyr Val Met Gly Phe Ala Gly Ala 145 150 155 160 Met Ala His Thr Val Cys Met Val Arg Leu Thr Phe Cys Ala Asn Asn 165 170 175 Leu Val Asp His Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Arg Ser 180 185 190 Cys Thr Ser Thr Tyr Val Asn Glu Leu Val Val Phe Ile Val Val Gly 195 200 205 Ile Asp Ile Gly Val Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu 210 215 220 Ile Leu Ser Ser Ile Leu Arg Ile His Ser Thr Lys Gly Arg Ser Lys 225 230 235 240 Ala Phe Ser Thr Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe 245 250 255

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Gly Ser Gly Ala 260 Phe Met Tyr Leu Lys Pro Ser Ser Leu Leu Pro Met 265 270 Asn Gln Gly Lys Val Ser Ser Leu Phe Tyr Thr Ile Val Val Pro Met 275 280 285 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ile Ala 290 295 300 Leu Lys Lys Thr Leu Ser Lys Lys Pro Phe Ser

305 310 315 <210> 51 <211> 315 <212> PRT

<213> Felis catus <400> 51 Met Lys Ser Lys Phe Glu Tyr Asn Arg Thr Ala Ile Thr Glu Phe Ile 1 5 10 15 Leu Leu Gly Leu Val Glu Thr Pro Asp Leu Arg Pro Val Val Phe Val 20 25 30 Val Phe Leu Leu Ser Tyr Leu Leu Thr Val Gly Gly Asn Leu Ser Ile 35 40 45 Leu Ala Ala Ile Leu Val Glu Pro Lys Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Val Leu Asp Ile Gly Cys Ile Thr Val Thr 65 70 75 80 Ile Pro Ser Met Leu Ala Arg Leu Leu Ser His Lys Arg Thr Val Pro 85 90 95 Tyr Gly Ala Cys Leu Thr Gln Leu Phe Phe Phe His Leu Leu Val Gly 100 105 110 Val Asp Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Phe Leu Ala

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115 069269_0225_SL.TXT 120 125 Ile Cys Gln Pro Leu Thr Tyr Ser Thr Arg Met Ser Gln Thr Val Gln 130 135 140 Arg Ile Leu Val Ala Val Ser Trp Ala Leu Ala Phe Thr Asn Ala Leu 145 150 155 160 Thr His Thr Val Ala Ile Ser Thr Leu Asn Phe Cys Gly Pro Asn Val 165 170 175 Ile Asn His Phe Tyr Cys Asp Leu Pro Gln Leu Phe Gln Leu Ser Cys 180 185 190 Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe Ala Val Gly Phe Ile 195 200 205 Met Ala Gly Thr Pro Leu Ala Leu Ile Val Thr Ser Tyr Ala His Val 210 215 220 Thr Ala Ala Val Leu Arg Ile Arg Ser Ala Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ala Ile Phe Tyr Gly 245 250 255 Ser Gly Ile Phe Asn Tyr Met Arg Leu Gly Ser Ala Lys Leu Ser Asp 260 265 270 Lys Asp Lys Ala Phe Gly Ile Phe Asn Thr Val Ile Asn Pro Met Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Pro Asp Val Gln Gly Ala Leu 290 295 300 Trp Arg Val Leu Met Gly Arg Arg Pro Leu Ala 305 310 315

<210> 52

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069269_0225_SL.TXT <211> 317 <212> PRT <213> Felis catus <400> 52

Met Gly Asn Trp Ser Arg Gly His Ile Ala Glu Phe Val Leu Val Gly 1 5 10 15 Phe Pro Thr Ser Pro Pro Leu Gln Cys Leu Leu Phe Val Leu Phe Leu 20 25 30 Ala Ile Tyr Leu Leu Thr Leu Leu Glu Asn Ala Leu Ile Val Ser Thr 35 40 45 Val Trp Leu Thr Pro Ser Leu His Arg Pro Met Tyr Phe Phe Leu Gly 50 55 60 His Leu Ser Phe Leu Glu Leu Trp Tyr Ile Asn Val Thr Val Pro Arg 65 70 75 80 Leu Leu Gly Ala Phe Leu Thr Gln Glu Arg Arg Val Ser Tyr Val Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Ile Ala Leu Ala Cys Thr Glu Cys 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Glu 115 120 125 Pro Leu Arg Tyr Pro Ser Leu Met Pro Ser Ser Leu Ala Ile Arg Leu 130 135 140 Ala Ala Ser Ser Trp Gly Ser Gly Phe Leu Ser Ser Met Met Lys Leu 145 150 155 160 Leu Phe Ile Ser Arg Leu Ser Tyr Cys Gly Pro Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Leu Leu Asn Leu Thr Cys Ser Asp Lys 180 185 190

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Glu Gln Ala Glu Leu Val Asp Phe Leu Leu Ala Leu Val Met Ile Leu 195 200 205 Leu Pro Leu Leu Ala Val Val Ser Ser Tyr Ala Ala Ile Met Ala Ala 210 215 220 Ile Leu Arg Ile Pro Thr Ala Gln Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ala Val Val Val Ile Tyr Tyr Ser Ser Thr Leu 245 250 255 Phe Thr Tyr Ala Arg Pro Gln Ala Met Tyr Thr Phe Asn His Asn Lys 260 265 270 Val Ile Ser Val Leu Tyr Thr Val Ile Val Pro Phe Leu Asn Pro Ala 275 280 285 Ile Tyr Cys Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Arg Lys Ser 290 295 300 Val Leu Gly Arg Cys His Tyr Pro Arg Asp Val Pro Asp

305 310 315 <210> 53 <211> 317 <212> PRT

<213> Felis catus <400> 53 Met Val Asp Thr Asn Gly Ser Glu Ser Ser Ala Thr Tyr Phe Ile Leu 1 5 10 15 Ile Gly Leu Pro Gly Leu Glu Lys Ala Gln Phe Trp Leu Ala Phe Pro 20 25 30 Leu Cys Ser Leu Tyr Leu Ile Ala Val Leu Gly Asn Leu Thr Val Ile 35 40 45 Cys Ile Val Arg Thr Glu His Arg Leu His Glu Pro Met Tyr Ile Phe

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50 55 60

Leu 65 Cys Met Leu Ser Gly Leu Asp Ile Leu Ile Ser Thr Ser Ser Met 70 75 80 Pro Arg Met Met Ala Ile Phe Trp Phe Asn Ser Thr Thr Ile Gln Phe 85 90 95 Asp Ala Cys Leu Leu Gln Met Phe Ala Ile His Ser Leu Ser Gly Met 100 105 110 Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg His Ala Thr Val Leu Thr Leu Pro Arg Val Thr 130 135 140 Lys Ile Gly Val Ala Ala Val Val Arg Gly Thr Ser Leu Met Ala Pro 145 150 155 160 Leu Pro Ile Phe Ile Lys Arg Leu Pro Phe Cys Arg Ser Asn Ile Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ala 180 185 190 Asp Ile Arg Val Asn Ile Ile Tyr Gly Leu Ile Val Ile Ile Ser Ala 195 200 205 Ile Gly Leu Asp Ser Leu Leu Ile Ser Leu Ser Tyr Leu Leu Ile Leu 210 215 220 Lys Thr Val Leu Gly Leu Thr Arg Glu Ala Gln Ala Lys Ala Phe Gly 225 230 235 240 Thr Cys Val Ser His Val Cys Ala Val Phe Ile Phe Tyr Val Pro Phe 245 250 255 Ile Gly Leu Ser Met Val His Arg Phe Gly Lys Arg His Asp Ser Leu

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260

069269_0225_SL.TXT 265 270

Leu Pro Ile Ile Met Ala Asn Thr 280 275 Asn Pro Ile Val Tyr Gly Val Lys 290 295 Leu Arg Leu Phe His Val Thr Thr

Tyr Leu Leu Val Pro Pro Val Leu 285

Thr Lys Glu Ile Arg Gln Arg Ile 300

His Thr Ser Asp Pro 315

305 310 <210> 54 <211> 320 <212> PRT

<213> Felis <400> 54 catus Met 1 Pro Arg Phe Thr Met Val Val 5 Pro Ile Phe Ile 20 Leu Arg Gly Phe Trp Ile Ser 35 Val Pro Phe Cys Leu 40 Asn Val 50 Thr Ile Leu Ser Val 55 Ile Pro 65 Met Tyr Tyr Phe Leu 70 Ser Ile Ser Met Ser Thr Leu 85 Pro Thr Met Arg Glu Ile Gln 100 Ala Ser Ala Cys Thr Phe Thr 115 Phe Leu Glu Ser Ser 120

Trp Asn Asn Asn Asn Thr Met Glu 10 15

His Gly Leu Glu Cys Val Tyr Ser 25 30

Ala Tyr Leu Val Ala Phe Ile Gly 45

Trp Ile Glu Ser Ser Leu His Gln 60

Leu Ala Leu Thr Asp Leu Gly Met 75 80

Leu Ala Val Leu Trp Leu Asp Ala 90 95

Tyr Ala Gln Leu Phe Phe Ile His 105 110

Val Leu Leu Ala Met Ala Phe Asp 125

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Arg Phe Val Ala Ile Cys Arg Pro Leu His Tyr Thr Thr Ile Leu Asn 130 135 140 Asn Ser Val Ile Gly Lys Ile Gly Leu Ala Cys Leu Leu Arg Ser Met 145 150 155 160 Gly Val Val Leu Pro Thr Pro Leu Leu Leu Arg His Tyr His Tyr Cys 165 170 175 His Asp Asn Ala Leu Ser His Thr Phe Cys Leu His Gln Asp Ile Leu 180 185 190 Lys Leu Ser Cys Ser Asp Ala Arg Ile Ser Ser Val Tyr Gly Leu Cys 195 200 205 Val Val Ile Thr Thr Leu Gly Val Asp Ser Val Cys Ile Leu Leu Ser 210 215 220 Tyr Ile Leu Ile Leu Asn Ala Val Leu Gly Ile Ala Ser His Glu Glu 225 230 235 240 Arg Arg Lys Ala Leu Asn Thr Cys Ile Ser His Ile Cys Val Val Leu 245 250 255 Ile Phe Phe Val Pro Val Ile Gly Val Ser Met Val His Arg Phe Gly 260 265 270 Lys His Leu Ser Pro Arg Ile His Ile Ile Met Ala Asp Ile Tyr Leu 275 280 285 Leu Phe Pro Pro Val Leu Asn Pro Ile Val Tyr Ser Ile Lys Thr Lys 290 295 300 Gln Ile Arg Leu Arg Ile Leu Arg Arg Phe Gly Leu Arg Arg Gly His 305 310 315 320

<210> 55 <211> 330 <212> PRT

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069269_0225_SL.TXT <213> Felis catus <400> 55

Met Phe Ile Val Ile His Ser Phe Val Thr Ser Ile Ser Leu Thr Ala 1 5 10 15 Leu Glu Ser Gln Asn Ala Thr Met His Phe Val Thr Glu Phe Val Leu 20 25 30 Leu Gly Phe Pro Gly Gln Arg Glu Met Gln Asn Phe Phe Phe Ser Leu 35 40 45 Ile Leu Val Val Tyr Leu Leu Thr Leu Leu Gly Asn Gly Val Ile Val 50 55 60 Tyr Val Val Lys Trp Asp Lys Arg Leu His Thr Pro Met Tyr Ile Leu 65 70 75 80 Leu Gly Asn Phe Ala Phe Leu Glu Ile Trp Tyr Ile Ser Ser Thr Val 85 90 95 Pro Asn Met Leu Val Thr Ile Leu Ser Glu Thr Lys Thr Ile Ser Phe 100 105 110 Thr Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr 115 120 125 Glu Cys Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile 130 135 140 Cys Arg Pro Leu His Tyr Pro Ser Ile Met Thr Gly Lys Leu Cys Val 145 150 155 160 Ile Leu Val Cys Val Cys Trp Val Ser Gly Phe Leu Cys Tyr Pro Ile 165 170 175 Pro Ile Val Leu Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn Ile Ile 180 185 190 Asp His Phe Val Cys Asp Pro Gly Pro Leu Phe Ala Leu Ala Cys Ile

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195 200 205 Pro Ala Pro Ser Thr Glu Leu Ile Cys Tyr Thr Phe Asn Ser Val Ile 210 215 220 Ile Phe Gly Pro Phe Leu Ser Ile Leu Gly Ser Tyr Thr Leu Val Leu 225 230 235 240 Arg Ala Val Leu Arg Ile Pro Ser Gly Ala Gly Gln Thr Lys Ala Phe 245 250 255 Ser Thr Cys Gly Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr 260 265 270 Leu Met Val Met Tyr Val Ser Pro Thr Ser Gly Asn Pro Ala Gly Met 275 280 285 Gln Lys Ile Val Thr Leu Val Tyr Ser Ala Val Thr Pro Leu Leu Asn 290 295 300 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys 305 310 315 320 Lys Leu Leu Gly Leu Arg Ser Asn Pro Asn

325 330 <210> 56 <211> 321 <212> PRT

<213> Felis catus His Gly Gln Ser Asn His Thr Asn Val <400> 56 Pro Asn Met Glu 1 Glu Gly Gly 5 10 15 Lys Glu Phe Val Phe Leu Glu Leu Thr His Phe Gln Glu Leu Glu Cys 20 25 30 Phe Leu Phe Val Ala Phe Leu Ala Val Tyr Val Thr Thr Val Leu Gly 35 40 45

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Asn Ala Leu Ile Val Leu Thr Ile Thr Tyr Glu Ser His Leu His Thr 50 55 60 Pro Met Tyr Phe Leu Leu Arg Asn Lys Ser Val Leu Asp Ile Val Phe 65 70 75 80 Ser Ser Val Thr Val Pro Lys Phe Leu Val Asp Leu Leu Ser Glu Arg 85 90 95 Lys Thr Ile Ser Tyr Asn Gly Cys Met Ala Gln Ile Phe Phe Phe His 100 105 110 Phe Ala Gly Gly Ala Asp Ile Phe Phe Leu Ser Val Met Ala Tyr Asp 115 120 125 Arg Tyr Leu Ala Ile Ala Lys Pro Leu His Tyr Val Thr Ile Met Lys 130 135 140 Arg Glu Val Trp Val Gly Leu Val Val Ala Ser Trp Val Gly Gly Gly 145 150 155 160 Leu His Ser Ile Val Gln Ile Ile Leu Met Leu Pro Leu Ser Phe Cys 165 170 175 Gly Pro Asn Ile Leu Asp Ala Phe Tyr Cys Asp Val Pro Gln Val Val 180 185 190 Lys Leu Ala Cys Thr Asp Thr Phe Ala Leu Glu Leu Leu Met Ile Ser 195 200 205 Asn Asn Gly Leu Val Thr Leu Leu Trp Phe Leu Leu Leu Leu Gly Ser 210 215 220 Tyr Thr Val Ile Leu Val Met Leu Arg Ser His Ser Gly Ala Gly Arg 225 230 235 240 Asn Lys Ala Leu Ser Thr Cys Thr Ser His Ile Leu Val Val Thr Leu 245 250 255

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His Phe Val Pro Cys Val Tyr Ile Tyr Cys Arg Pro Phe Thr Thr Leu 260 265 270 Pro Met Asp Thr Ala Val Ser Ile Asn Asn Thr Val Ile Thr Pro Met 275 280 285 Leu Asn Pro Met Ile Tyr Thr Leu Arg Asn Gln Glu Met Lys Ser Ala 290 295 300 Met Lys Arg Leu His Arg Arg Leu Gly Pro Ser Glu Ser Ser Lys Leu 305 310 315 320 Gly <210> 57 <211> 312 <212> PRT <213> Felis catus <400> 57 Met Asp Ala Leu Asn Gln Thr Arg Val Thr Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Thr Asp Lys Trp Val Leu Glu Ile Leu Phe Phe Leu Ala Phe Ser 20 25 30 Val Thr Tyr Val Leu Thr Leu Leu Gly Asn Thr Leu Ile Ile Val Thr 35 40 45 Ile Val Phe Thr Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Ile Cys His Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Gly Leu Leu Leu Glu Ile Lys Thr Ile Ser Phe Asp Asn 85 90 95 Cys Ile Ala Gln Leu Phe Phe Leu His Leu Phe Ala Cys Ala Glu Ile

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100

069269_0225_SL.TXT 105 110

Phe Leu Leu 115 Thr Ile Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ala 120 125 Pro Leu His Tyr Ser Asn Val Met Asn Met Arg Val Cys Val Gln Leu 130 135 140 Val Phe Ala Leu Trp Leu Gly Ala Thr Val His Ser Leu Val Gln Thr 145 150 155 160 Phe Leu Thr Ile Arg Leu Pro Tyr Cys Gly Pro Asn Ile Ile Asp Ser 165 170 175 Tyr Phe Cys Asp Val Pro Pro Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Tyr Leu Thr Gly Met Leu Ile Val Ser Asn Ser Gly Thr Ile Ser Leu 195 200 205 Thr Cys Phe Leu Ala Leu Val Thr Ser Tyr Thr Val Ile Leu Val Ser 210 215 220 Leu Arg Lys Gln Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys 225 230 235 240 Ser Ala His Phe Met Val Val Ala Phe Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Thr Arg Pro Asp Thr Ser Phe Ser Ile Asp Lys Val Val Ser 260 265 270 Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr 275 280 285 Leu Arg Asn Glu Glu Val Lys Ser Ala Met Lys His Leu Arg Gln Arg 290 295 300 Gly Phe Phe Met Lys Ser Gly Thr

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305 310 <210> 58 <211> 312 <212> PRT <213> Felis catus <400> 58

Met 1 Ala Glu Ala Asn 5 Asn Ser Phe Ser Glu Gly Cys Ile Leu Met Gly 10 15 Ile Ser Asp His Pro Gln Leu Glu Ile Val Phe Phe Ile Val Ile Leu 20 25 30 Phe Ser Tyr Ser Leu Thr Leu Val Gly Asn Ser Thr Thr Ile Leu Leu 35 40 45 Ser Cys Leu Asp Ala Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Ser Leu Asp Leu Ala Phe Thr Thr Ser Ser Val Pro Gln 65 70 75 80 Met Leu Thr Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Val Ile Gln Leu Tyr Val Phe Leu Trp Leu Gly Ala Thr Glu Cys 100 105 110 Ile Leu Leu Val Val Met Ala Phe Asp Arg His Val Ala Val Cys Gln 115 120 125 Pro Leu Arg Tyr Thr Val Ile Val Ser Pro Arg Leu Cys Arg Leu Leu 130 135 140 Ala Ala Ile Ala Trp Leu Gly Gly Leu Ser Asn Ser Met Ile Gln Ser 145 150 155 160 Thr Phe Thr Leu Gln Leu Pro Leu Cys Gly His Arg Arg Val Asp Asn 165 170 175

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Phe Leu Cys Glu Val Pro Ala Met Ile Lys Leu Ala Cys Gly Asp Thr 180 185 190 Ser Leu Asn Glu Ala Val Leu Asn Gly Val Cys Thr Phe Phe Thr Ala 195 200 205 Val Pro Leu Ser Ile Ile Leu Ile Ser Tyr Cys Ser Ile Ala Arg Ala 210 215 220 Val Leu Lys Ile Arg Ser Ala Glu Gly Gln Arg Lys Ala Phe Asn Thr 225 230 235 240 Cys Leu Ser His Leu Val Val Val Leu Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Tyr Gly Tyr Leu Leu Pro Ala Lys Thr Ser His Gln Gly Gln Gly Lys 260 265 270 Phe Ile Ser Leu Phe Tyr Ser Val Val Thr Pro Met Val Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Leu Arg Arg Leu 290 295 300 Arg Gly Lys Gly Arg Glu Phe Gly

305 310 <210> 59 <211> 318 <212> PRT

<213> Felis catus <400> 59 Met Arg Ser Met Ser Thr Ala Lys Ala Trp Asn Ser Ser Ser Val Thr 1 5 10 15 Met Phe Ile Phe Leu Gly Phe Ala Asp His Pro Glu Leu Gln Thr Leu 20 25 30 Leu Phe Val Thr Phe Leu Gly Ile Tyr Leu Val Thr Leu Ala Trp Asn

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Leu Ala Leu Ile Phe Leu Ile Arg Gly Asp Pro Arg Leu His Thr Pro 50 55 60 Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Ile Asp Ile Cys Tyr Ser 65 70 75 80 Ser Thr Val Ala Pro Lys Met Leu Thr Asp Phe Phe Trp Glu Gln Lys 85 90 95 Thr Ile Ser Phe Leu Gly Cys Ala Ala Gln Phe Phe Phe Phe Val Ser 100 105 110 Met Gly Leu Thr Glu Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg 115 120 125 Tyr Ala Ala Ile Ser Asn Pro Leu Leu Tyr Thr Ala Ile Met Ser Gln 130 135 140 Gly Leu Cys Thr Arg Met Val Leu Gly Ala Tyr Val Gly Gly Phe Leu 145 150 155 160 Ser Ser Leu Ile Gln Ala Ser Ser Ile Phe Gln Leu His Phe Cys Gly 165 170 175 Pro Asn Ile Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Ala 180 185 190 Leu Ser Cys Ser Asp Thr Phe Pro Ser Gln Val Val Asn Phe Leu Val 195 200 205 Val Val Thr Ile Gly Gly Thr Ser Phe Leu Ile Leu Ile Ile Ser Tyr 210 215 220 Ser Tyr Ile Gly Thr Ala Val Leu Lys Ile Arg Ser Val Glu Gly Arg 225 230 235 240 Lys Lys Ala Phe Ser Thr Cys Ala Ser His Leu Met Val Val Thr Leu

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245 250 255

Leu Phe Gly Thr Ala Leu Phe Met Tyr Leu Arg Pro Ser Ser Ser Tyr 260 265 270 Ser Leu Gly Arg Asp Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Arg Glu Ile Lys 290 295 300 Asp Ala Leu Trp Lys Val Leu Glu Lys Lys Lys Leu Phe Ser

305 310 315 <210> 60 <211> 314 <212> PRT <213> Felis catus <400> 60

Met Pro Leu Met Arg Met Ala Ala Glu Asn Ser Ser Val Thr Glu Phe 1 5 10 15 Ile Leu Ala Gly Leu Thr Asn Gln Pro Gly Leu Arg Met Pro Leu Phe 20 25 30 Phe Leu Phe Leu Gly Phe Tyr Val Val Thr Val Met Gly Asn Leu Gly 35 40 45 Leu Ile Thr Leu Ile Gly Leu Asn Ser His Leu His Thr Pro Met Tyr 50 55 60 Phe Phe Leu Phe Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Thr Val 65 70 75 80 Ile Thr Pro Lys Met Leu Met Ser Phe Val Ser Lys Asn Thr Ile Ala 85 90 95 Tyr Ala Gly Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val Val 100 105 110

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Ser Glu Ser 115 Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Thr Ala 120 125 Ile Cys Asn Pro Leu Val Tyr Thr Ala Thr Met Ser Pro Gln Val Cys 130 135 140 Ser Leu Leu Leu Leu Gly Val Tyr Val Met Gly Phe Ala Gly Ala Met 145 150 155 160 Ala His Thr Thr Cys Met Val Arg Leu Thr Phe Cys Ala Asn Asn Leu 165 170 175 Val Asp His Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Arg Ser Cys 180 185 190 Thr Ser Thr Tyr Val Asn Glu Leu Val Val Phe Val Val Val Gly Ile 195 200 205 Asp Ile Gly Val Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu Ile 210 215 220 Leu Thr Ser Ile Leu His Ile Arg Ser Thr Glu Gly Arg Ser Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly 245 250 255 Ser Gly Ala Phe Met Tyr Leu Lys Pro Ser Ser Leu Leu Pro Met Asn 260 265 270 Gln Gly Lys Val Ser Ser Leu Phe Tyr Thr Thr Val Val Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu 290 295 300 Lys Lys Ser Leu Ser Lys Lys Thr Phe Ser

305 310

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069269_0225_SL.TXT <210> 61 <211> 531 <212> DNA <213> Canis familiaris <400> 61

aatctcacag cagtatctgt cttcctcctt tggggcttct cggctgtgcc caagttacag 60 ctgcttgact cggccacctt ccttctcatt tatctggctg cgattttggg aaacattgct 120 atcctggctg ccgtgagaca caacacctgc ctgcacacac ccatgtactt cttcctcaaa 180 catctgtcct tggtggatgt ctgctccgtg tccaccaccc tgccccaggc cccagtggtg 240 accgtgctgg gctccgagat ttccctccat gcatgtgcat tccagctctt tgcttttgtc 300 tgctttgggt ccacagagtg ttttctcatc acttgcatgg ctttcaatcg ttgtctggcc 360 atctacaggg ccctggtgta cagggaagcc atgagcctgg ggacctgcat ttctctggtg 420 tcagtggcct ggggcagtgg gctcattttc tctgccttcc acacagccaa caccttcttc 480 ctgcccttct gtggccccag tgtgattgac cacttcttct gcgacattcc t 531

<210> 62 <211> 177 <212> PRT <213> Canis familiaris <400> 62

Asn Leu Thr Ala Val Ser Val Phe Leu Leu Trp Gly Phe Ser Ala Val 1 5 10 15 Pro Lys Leu Gln Leu Leu Asp Ser Ala Thr Phe Leu Leu Ile Tyr Leu 20 25 30 Ala Ala Ile Leu Gly Asn Ile Ala Ile Leu Ala Ala Val Arg His Asn 35 40 45 Thr Cys Leu His Thr Pro Met Tyr Phe Phe Leu Lys His Leu Ser Leu 50 55 60 Val Asp Val Cys Ser Val Ser Thr Thr Leu Pro Gln Ala Pro Val Val 65 70 75 80

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Thr Val Leu Gly Ser 85 Glu Ile Ser Leu His Ala Cys Ala Phe Gln Leu 90 95 Phe Ala Phe Val Cys Phe Gly Ser Thr Glu Cys Phe Leu Ile Thr Cys 100 105 110 Met Ala Phe Asn Arg Cys Leu Ala Ile Tyr Arg Ala Leu Val Tyr Arg 115 120 125 Glu Ala Met Ser Leu Gly Thr Cys Ile Ser Leu Val Ser Val Ala Trp 130 135 140 Gly Ser Gly Leu Ile Phe Ser Ala Phe His Thr Ala Asn Thr Phe Phe 145 150 155 160 Leu Pro Phe Cys Gly Pro Ser Val Ile Asp His Phe Phe Cys Asp Ile 165 170 175

Pro <210> 63 <211> 990 <212> DNA <213> Canis familiaris <400> 63

atgccgaccg cctgggcccc cccgggcgcc cccgaagccc ccccctgcgc caaccagagc 60 tgcgtcccca gtgagctggt cctgctgggc ttcgcgcacg tgcccgcgct gcggccgctg 120 ctcgccacgc tcttcctggc catgttcctg ctcacgctgc tgggcaacgc gctcatcgtg 180 ctgctgaccg ccctggaccc ggccctgcgc gcgcccatgt acctgttcct gcgccacctg 240 gccctggtgg agatgtgctt ctcgctggac atcgtgccgc agctgcttct gaccctgctg 300 cggcccgggc ggggcgtgtc tcccgccggc tgcgccctgc agctgctgct ggtgttgtcc 360 tgcgtcacgt ccgagtgctt cctcctgacg accatggcct gggaccgcta cgtggccatc 420 tgcaggcctc tgcgttatgg cgccatcgtg agcccgcggc tctgccacct gctggccgcc 480 acgtgctggc tggctggcgt ccctgtgtct ctggtcttca ccatctggct gttccgcttc 540

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cccttctgcg ggccccgagg catccgccac ttcttctgtg acatcgcgcc tctgctgagc 600 ctggtgtgtg cagacaccag agtcttcgag gccaacgtgt tggcggccac ggtgctggtt 660 atcatggttc ccttctgtct gatagccgcg tcctacacca agattctggc caccgtgctg 720 cggatgccat ctgccagggg gcgccacaag gccctgtcca cgtgcgcctc tcacttcgtc 780 gtggtgcttc tgttttatgg caccacgggg gtcatccact tgcgacccaa gggcagctac 840 tccccggaga gcaagcaggt ggtgtccttg tcctacaccc tggtaacccc catgctcaac 900 cccctcatct acagccttcg aaacaaggag gtgagggctg ccctgggacg cgtgtgttgc 960 catggccagg aatctggacc ccatgaatga 990

<210> 64 <211> 329 <212> PRT <213> Canis familiaris <400> 64

Met Pro Thr Ala Trp Ala Pro Pro Gly Ala Pro Glu Ala Pro Pro Cys 1 5 10 15 Ala Asn Gln Ser Cys Val Pro Ser Glu Leu Val Leu Leu Gly Phe Ala 20 25 30 His Val Pro Ala Leu Arg Pro Leu Leu Ala Thr Leu Phe Leu Ala Met 35 40 45 Phe Leu Leu Thr Leu Leu Gly Asn Ala Leu Ile Val Leu Leu Thr Ala 50 55 60 Leu Asp Pro Ala Leu Arg Ala Pro Met Tyr Leu Phe Leu Arg His Leu 65 70 75 80 Ala Leu Val Glu Met Cys Phe Ser Leu Asp Ile Val Pro Gln Leu Leu 85 90 95 Leu Thr Leu Leu Arg Pro Gly Arg Gly Val Ser Pro Ala Gly Cys Ala 100 105 110 Leu Gln Leu Leu Leu Val Leu Ser Cys Val Thr Ser Glu Cys Phe Leu

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115 069269_0225_SL.TXT 120 125 Leu Thr Thr Met Ala Trp Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 130 135 140 Arg Tyr Gly Ala Ile Val Ser Pro Arg Leu Cys His Leu Leu Ala Ala 145 150 155 160 Thr Cys Trp Leu Ala Gly Val Pro Val Ser Leu Val Phe Thr Ile Trp 165 170 175 Leu Phe Arg Phe Pro Phe Cys Gly Pro Arg Gly Ile Arg His Phe Phe 180 185 190 Cys Asp Ile Ala Pro Leu Leu Ser Leu Val Cys Ala Asp Thr Arg Val 195 200 205 Phe Glu Ala Asn Val Leu Ala Ala Thr Val Leu Val Ile Met Val Pro 210 215 220 Phe Cys Leu Ile Ala Ala Ser Tyr Thr Lys Ile Leu Ala Thr Val Leu 225 230 235 240 Arg Met Pro Ser Ala Arg Gly Arg His Lys Ala Leu Ser Thr Cys Ala 245 250 255 Ser His Phe Val Val Val Leu Leu Phe Tyr Gly Thr Thr Gly Val Ile 260 265 270 His Leu Arg Pro Lys Gly Ser Tyr Ser Pro Glu Ser Lys Gln Val Val 275 280 285 Ser Leu Ser Tyr Thr Leu Val Thr Pro Met Leu Asn Pro Leu Ile Tyr 290 295 300 Ser Leu Arg Asn Lys Glu Val Arg Ala Ala Leu Gly Arg Val Cys Cys 305 310 315 320 His Gly Gln Glu Ser Gly Pro His Glu

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325 <210> 65 <211> 675 <212> DNA <213> Canis familiaris <400> 65

ggggcttgga ctggaccctg ccatgtaccc ttcacagcct gcatgaccca gctattcttc 60 tttatagtcc tcatctgcac ggagtgcacc ctcctggcct ccatggccta tgaccgctac 120 gtggccatct gccgccctct ccactaccca ctgctcatga ggccccaggt ctgcctgggc 180 ttggccttgt cttcatggat tggggggctg ctggtctcag tggtcaagac atcttgcatt 240 gccagcctgt cctactgtgg ccccaatgtc ctcaaccaat ttttctgtga tgtctcccct 300 ctgctcaacc tgtcttgcac ccacgtggcc ctgacggagc tggtggactt catctctgcc 360 atcgtcatct tctgtggaac actgttggca gcattagcct cctactcagc catcgtggtg 420 gctgtgctcc tcatgccatc agccgctgcc cgacgcaagg ccttttccac ctgtgcctcc 480 cacctgattg tggtgggcat cttctactca gcagccctct tcatctactg ccgtcccagc 540 cgtatcaaat ccatggacct caacaaggtg ctgtcagtca tctacacggt agtcacgccc 600 atgtgcaacc ccatcatcta ctgcctgagg aacaaagagg tccatgtggt gcttcggaaa 660 actctccact ggcct 675

<210> 66 <211> 225 <212> PRT <213> Canis familiaris <400> 66

Gly 1 Ala Trp Thr Gly Pro Cys His Val Pro Phe Thr Ala Cys Met Thr 5 10 15 Gln Leu Phe Phe Phe Ile Val Leu Ile Cys Thr Glu Cys Thr Leu Leu 20 25 30 Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu His 35 40 45

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Tyr Pro 50 Leu Leu Met Arg Pro 55 069269_0225_SL.TXT Ala Leu Ser Gln Val Cys Leu Gly Leu 60 Ser Trp Ile Gly Gly Leu Leu Val Ser Val Val Lys Thr Ser Cys Ile 65 70 75 80 Ala Ser Leu Ser Tyr Cys Gly Pro Asn Val Leu Asn Gln Phe Phe Cys 85 90 95 Asp Val Ser Pro Leu Leu Asn Leu Ser Cys Thr His Val Ala Leu Thr 100 105 110 Glu Leu Val Asp Phe Ile Ser Ala Ile Val Ile Phe Cys Gly Thr Leu 115 120 125 Leu Ala Ala Leu Ala Ser Tyr Ser Ala Ile Val Val Ala Val Leu Leu 130 135 140 Met Pro Ser Ala Ala Ala Arg Arg Lys Ala Phe Ser Thr Cys Ala Ser 145 150 155 160 His Leu Ile Val Val Gly Ile Phe Tyr Ser Ala Ala Leu Phe Ile Tyr 165 170 175 Cys Arg Pro Ser Arg Ile Lys Ser Met Asp Leu Asn Lys Val Leu Ser 180 185 190 Val Ile Tyr Thr Val Val Thr Pro Met Cys Asn Pro Ile Ile Tyr Cys 195 200 205 Leu Arg Asn Lys Glu Val His Val Val Leu Arg Lys Thr Leu His Trp 210 215 220

Pro

225 <210> 67 <211> 945 <212> DNA <213> Canis familiaris

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069269_0225_SL.TXT <400> 67

atggagaggt ccctggagtt gggcaacatg accagagtcc aggagtttgt cttgctgggt 60 ttgtccacca ggcctggcat aaggaatgtc ctgtttgctg tcttcctgac cctctacctg 120 ctgaccctcc tggaaaacac cctcatcatc tacctcatct gcagtcacag tgagctccac 180 aagcccatgt acttcttctt gggtaacctg agctgcctag agatgtgcta tgtgtcagtg 240 accatgccca gcctgctcct ggggctttgg actggaccct gccatgtacc cttcacagcc 300 tgcatgaccc agctcttctt cttcatctct ctcatctgca tggagtgcac tctcttggcc 360 tccatggctt atgatcgcta tgtggccatc tgccacccac tccactaccc actgcttatg 420 aggccccagg tctgcctggg cttggctttg tcctcatggc ttggggggct gctggtctca 480 gtggtaaaga catcttgcat tgccagcctg tcctactgtg gccccaatgt cctcaaccac 540 ttcttctgtg acgtctcccc tctgcttaac ctgtcttgca cccacgtggc tctgacagag 600 ctggtggact tcatctctgc catcatcatt ctctggggtt ctctccttgt ggctatagcg 660 tcctatgtag ccatcgggag ggctgtgctc tgcatgtcat cagctgttgc ccgtcgcaaa 720 gctctctcca cctgtgcctc acacctggtg gtggtcggca tcttctatgc agccactctc 780 ttcatctacg cccgtcccag ccgcatagaa gccatggacc tcaacaaggt gctgtcagtc 840 atctatacag tggtcacgcc catgtgcaac cccatcatct actgcctgcg taacagggag 900 gtccaggcag cattccacag aaccctacac tggtcccgaa gctga 945

<210> 68 <211> 314 <212> PRT <213> Canis familiaris <400> 68

Met 1 Glu Arg Ser Leu Glu Leu Gly Asn Met Thr Arg Val Gln Glu Phe 5 10 15 Val Leu Leu Gly Leu Ser Thr Arg Pro Gly Ile Arg Asn Val Leu Phe 20 25 30 Ala Val Phe Leu Thr Leu Tyr Leu Leu Thr Leu Leu Glu Asn Thr Leu 35 40 45

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Ile Ile 50 Tyr Leu Ile Cys Ser 55 His Phe 65 Phe Leu Gly Asn Leu 70 Ser Cys Thr Met Pro Ser Leu 85 Leu Leu Gly Pro Phe Thr Ala 100 Cys Met Thr Gln Cys Met Glu 115 Cys Thr Leu Leu Ala 120 Ala Ile 130 Cys His Pro Leu His 135 Tyr Cys 145 Leu Gly Leu Ala Leu 150 Ser Ser Val Val Lys Thr Ser 165 Cys Ile Ala Val Leu Asn His 180 Phe Phe Cys Asp Cys Thr His 195 Val Ala Leu Thr Glu 200 Ile Ile 210 Leu Trp Gly Ser Leu 215 Leu Ile 225 Gly Arg Ala Val Leu 230 Cys Met Ala Leu Ser Thr Cys 245 Ala Ser His

Glu Leu His 60 Lys Pro Met Tyr Glu Met 75 Cys Tyr Val Ser Val 80 Trp 90 Thr Gly Pro Cys His 95 Val Phe Phe Phe Ile Ser 110 Leu Ile Met Ala Tyr Asp 125 Arg Tyr Val Leu Leu Met 140 Arg Pro Gln Val Leu Gly 155 Gly Leu Leu Val Ser 160 Leu 170 Ser Tyr Cys Gly Pro 175 Asn Ser Pro Leu Leu Asn 190 Leu Ser Val Asp Phe Ile 205 Ser Ala Ile Ala Ile Ala 220 Ser Tyr Val Ala Ser Ala 235 Val Ala Arg Arg Lys 240 Val 250 Val Val Gly Ile Phe 255 Tyr

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Ala Ala Thr Leu Phe Ile Tyr Ala Arg 265 Pro Ser Arg Ile Glu 270 Ala Met 260 Asp Leu Asn Lys Val Leu Ser Val Ile Tyr Thr Val Val Thr Pro Met 275 280 285 Cys Asn Pro Ile Ile Tyr Cys Leu Arg Asn Arg Glu Val Gln Ala Ala 290 295 300 Phe His Arg Thr Leu His Trp Ser Arg Ser 305 310

<210> 69 <211> 975 <212> DNA <213> Canis familiaris <400> 69

atggagaggt ccctggagtt gggcaacatg accagagtcc aggagtttgt cttgctgggt 60 ttgtccacca ggcctggcat aaggaatgtc ctgtttgctg tcttcctgac cctctacctg 120 ctgaccctcc tggaaaacac cctcatcatc tacctcatct gcagtcacag cgagctccac 180 aagcccatgt acttcttctt gggtaacctg agctgcctag agatgtgcta tgtgtcagtg 240 accatgccca gcctgctcct ggggctttgg actggaccct gccatgtacc cttcacagcc 300 tgcataattc agcttttttt attcatagct ttcattagta ccaagtgcac cctcctggcc 360 tccatggctt atgatcgcta tgtggccatc tgccacccac tccactaccc actgcttatg 420 aggccccagg tctgcctggg cttggctttg tcctcatggc ttggggggct gctggtctca 480 gtggtaaaga catcttgcat tgccagcctg tcctactgtg gccccaatgt cctcaaccac 540 ttcttctgtg acgtctcccc tctgctcaac ctgtcttgca cccatgtggc cctgacggag 600 ctggtggact tcatctctgc catcattatc ttctgtgggt cattactagt tgctttggcc 660 tcctatgtag ccattgggaa cactgtgctc cacatgccat cggcagccac ccgtcgcaaa 720 gccctctcca cctgtgcctc acacctgttg gtggtgggca tgttctacgc agtggtcctc 780 ttcatatatt cccaccccag acacatcaat tctacagggc tcagcaaggt gctgtcagtc 840 atctatacga tggtcacacc catgtgcagc cctatcatct actgcctgcg gaacagagag 900

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069269_0225_SL.TXT gtccacgtcg cgctgcagaa aactctccac ttgtgctggg tctcttcagt tagaactgac cttgcccact cttga

960

975 <210> 70 <211> 324 <212> PRT <213> Canis familiaris <400> 70

Met Glu 1 Arg Ser Leu Glu Leu Gly Asn Met Thr Arg Val Gln Glu Phe 5 10 15 Val Leu Leu Gly Leu Ser Thr Arg Pro Gly Ile Arg Asn Val Leu Phe 20 25 30 Ala Val Phe Leu Thr Leu Tyr Leu Leu Thr Leu Leu Glu Asn Thr Leu 35 40 45 Ile Ile Tyr Leu Ile Cys Ser His Ser Glu Leu His Lys Pro Met Tyr 50 55 60 Phe Phe Leu Gly Asn Leu Ser Cys Leu Glu Met Cys Tyr Val Ser Val 65 70 75 80 Thr Met Pro Ser Leu Leu Leu Gly Leu Trp Thr Gly Pro Cys His Val 85 90 95 Pro Phe Thr Ala Cys Ile Ile Gln Leu Phe Leu Phe Ile Ala Phe Ile 100 105 110 Ser Thr Lys Cys Thr Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu His Tyr Pro Leu Leu Met Arg Pro Gln Val 130 135 140 Cys Leu Gly Leu Ala Leu Ser Ser Trp Leu Gly Gly Leu Leu Val Ser 145 150 155 160

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Val Val Lys Thr Ser Cys Ile Ala Ser Leu Ser Tyr Cys Gly Pro Asn 165 170 175 Val Leu Asn His Phe Phe Cys Asp Val Ser Pro Leu Leu Asn Leu Ser 180 185 190 Cys Thr His Val Ala Leu Thr Glu Leu Val Asp Phe Ile Ser Ala Ile 195 200 205 Ile Ile Phe Cys Gly Ser Leu Leu Val Ala Leu Ala Ser Tyr Val Ala 210 215 220 Ile Gly Asn Thr Val Leu His Met Pro Ser Ala Ala Thr Arg Arg Lys 225 230 235 240 Ala Leu Ser Thr Cys Ala Ser His Leu Leu Val Val Gly Met Phe Tyr 245 250 255 Ala Val Val Leu Phe Ile Tyr Ser His Pro Arg His Ile Asn Ser Thr 260 265 270 Gly Leu Ser Lys Val Leu Ser Val Ile Tyr Thr Met Val Thr Pro Met 275 280 285 Cys Ser Pro Ile Ile Tyr Cys Leu Arg Asn Arg Glu Val His Val Ala 290 295 300 Leu Gln Lys Thr Leu His Leu Cys Trp Val Ser Ser Val Arg Thr Asp 305 310 315 320

Leu Ala His Ser <210> 71 <211> 939 <212> DNA <213> Canis familiaris <400> 71 atggagagtt ctctggagtt gggcaacatg accagagtcc aggagtttgt cttgctgggt

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ttgtccacca ggccgggcat aaggaatgcc ctgtttgctg tcttcctgac cctctacctg 120 ctgaccctcc tggaaaacac cctcatcatc tacctcatct gcagtcacag cgagctccac 180 aagcccatgt acttcttctt gggtaacctg agctgcctag agatgtgcta tgtgtcagtg 240 accatgccca gtctgctcct ggggctttgg actggaccct gccatgtacc cttcacagcc 300 tgcatgaccc agctattctt ctttatagtc ctcatctgca cggagtgcac cctcctggcc 360 tccatggcct atgaccgcta cgtggccatc tgccgccctc tccactaccc actgctcatg 420 aggccccagg tctgcctggg cttggccttg tcttcatgga ttggggggct gctggtctca 480 gtggtcaaga catcttgcat tgccagcctg tcctactgtg gccccaatgt cctcaaccaa 540 tttttctgtg atgtctcccc tctgctcaac ctgtcttgca cccacgtggc cctgacggag 600 ctggtggact tcatctctgc catcgtcatc ttctgtggaa cactgttggc agcattagcc 660 tcctactcag ccatcgtggt ggctgtgctc ctcatgccat cagccgctgc ccgacgcaag 720 gccttttcca cctgtgcctc ccacctgatt gtggtgggca tcttctactc agcagccctc 780 ttcatctact gccgtcccag ccgtatcaaa tccatggacc tcaacaaggt gctgtcagtc 840 atctacacgg tagtcacgcc catgtgcaac cccatcatct actgcctgag gaacaaagag 900 gtccatgtgg tgcttcggaa aactctccac tggccttga 939

<210> 72 <211> 312 <212> PRT <213> Canis familiaris <400> 72

Met Glu Ser Ser Leu Glu Leu Gly Asn Met Thr Arg Val Gln Glu Phe 1 5 10 15 Val Leu Leu Gly Leu Ser Thr Arg Pro Gly Ile Arg Asn Ala Leu Phe 20 25 30 Ala Val Phe Leu Thr Leu Tyr Leu Leu Thr Leu Leu Glu Asn Thr Leu 35 40 45 Ile Ile Tyr Leu Ile Cys Ser His Ser Glu Leu His Lys Pro Met Tyr 50 55 60

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Phe Phe 65 Leu Gly Asn Leu 70 Ser Cys Leu Glu Met Cys Tyr Val Ser Val 75 80 Thr Met Pro Ser Leu Leu Leu Gly Leu Trp Thr Gly Pro Cys His Val 85 90 95 Pro Phe Thr Ala Cys Met Thr Gln Leu Phe Phe Phe Ile Val Leu Ile 100 105 110 Cys Thr Glu Cys Thr Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys Arg Pro Leu His Tyr Pro Leu Leu Met Arg Pro Gln Val 130 135 140 Cys Leu Gly Leu Ala Leu Ser Ser Trp Ile Gly Gly Leu Leu Val Ser 145 150 155 160 Val Val Lys Thr Ser Cys Ile Ala Ser Leu Ser Tyr Cys Gly Pro Asn 165 170 175 Val Leu Asn Gln Phe Phe Cys Asp Val Ser Pro Leu Leu Asn Leu Ser 180 185 190 Cys Thr His Val Ala Leu Thr Glu Leu Val Asp Phe Ile Ser Ala Ile 195 200 205 Val Ile Phe Cys Gly Thr Leu Leu Ala Ala Leu Ala Ser Tyr Ser Ala 210 215 220 Ile Val Val Ala Val Leu Leu Met Pro Ser Ala Ala Ala Arg Arg Lys 225 230 235 240 Ala Phe Ser Thr Cys Ala Ser His Leu Ile Val Val Gly Ile Phe Tyr 245 250 255 Ser Ala Ala Leu Phe Ile Tyr Cys Arg Pro Ser Arg Ile Lys Ser Met 260 265 270

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Asp Leu Asn Lys Val Leu Ser Val Ile Tyr Thr Val Val Thr Pro Met 275 280 285 Cys Asn Pro Ile Ile Tyr Cys Leu Arg Asn Lys Glu Val His Val Val 290 295 300 Leu Arg Lys Thr Leu His Trp Pro 305 310

<210> 73 <211> 492 <212> DNA <213> Canis familiaris <400> 73 ggcgtccctg tgtctctggt cttcaccatc tggctgttcc gcttcccctt ctgcgggccc 60 cgaggcatcc gccacttctt ctgtgacatc gcgcctctgc tgagcctggt gtgtgcagac 120 accagagtct tcgaggccaa cgtgttggcg gccacggtgc tggttatcat ggttcccttc 180 tgtctgatag ccgcgtccta caccaagatt ctggccaccg tgctgcggat gccatctgcc 240 agggggcgcc acaaggccct gtccacgtgc gcctctcact tcgtcgtggt gcttctgttt 300 tatggcacca cgggggtcat ccacttgcga cccaagggca gctactcccc ggagagcaag 360 caggtggtgt ccttgtccta caccctggta acccccatgc tcaaccccct catctacagc 420 cttcgaaaca aggaggtgag ggctgccctg ggacgcgtgt gttgccatgg ccaggaatct 480 ggaccccatg aa 492 <210> 74 <211> 164 <212> PRT <213> Canis familiaris <400> 74

Gly Val Pro Val Ser Leu Val Phe Thr Ile Trp Leu Phe Arg Phe Pro 1 5 10 15

Phe Cys Gly Pro Arg Gly Ile Arg His Phe Phe Cys Asp Ile Ala Pro 20 25 30

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Leu Leu Ser 35 Leu Val Cys Ala 069269_0225_SL.TXT Asp Thr Arg Val Phe Glu 40 45 Ala Asn Val Leu Ala Ala Thr Val Leu Val Ile Met Val Pro Phe Cys Leu Ile Ala 50 55 60 Ala Ser Tyr Thr Lys Ile Leu Ala Thr Val Leu Arg Met Pro Ser Ala 65 70 75 80 Arg Gly Arg His Lys Ala Leu Ser Thr Cys Ala Ser His Phe Val Val 85 90 95 Val Leu Leu Phe Tyr Gly Thr Thr Gly Val Ile His Leu Arg Pro Lys 100 105 110 Gly Ser Tyr Ser Pro Glu Ser Lys Gln Val Val Ser Leu Ser Tyr Thr 115 120 125 Leu Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys 130 135 140 Glu Val Arg Ala Ala Leu Gly Arg Val Cys Cys His Gly Gln Glu Ser 145 150 155 160 Gly Pro His Glu

<210> 75 <211> 879 <212> DNA <213> Canis familiaris <400> 75

atgggcagcc aaaacagcac agaggaggtc tacttcattc tgcttgggct ctcccagtac 60 ccatgggctc aaaccatctt cctctgcctg atcttcctgt cctatatcat caatcttttc 120 gggaacagcc tcatcctgct cctgatctgc tatgattgat ccccggctcc acacgcccat 180 gtacttcttc ctcttcaact tcttcctctt ccatgtactt ccttcctgga cgtgtgctac 240 accatatcca gcatgcccca gatcctcatc aaatgcctgg tgaccattca catcatctcg 300

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ctaggttgat gcttggcccg gatggctgtg ggactttatc tgggtgtagt ggagtgtctc 360 ctgatggcca ccgtggccta tgatcactgt gtggccattg ttgaccccct gtgctattcc 420 aggcatatgg ggccctggct ttgcagtctg ttggctggga cctcatggtc tgtggtgttc 480 ctgctgacca cggtccctgt gctgaccatg cccttggagt tctgtgttca ccaggtcatc 540 aatcacttat cgtgcgagct cctggccctg ctcaagcttg cctgctctca cctgcagttc 600 tatgagtcac tcatggtggg caccagtgcc ctgaccctgc tggctccttt tgccttcatc 660 gtggcctcct acagaaggat cttagtgtct gtgctgcggc tgcggtctgc agggggccat 720 gccaaggcct tttccacatg tgggtctcac ctcacagtgg tggccctctt ctatggcacg 780 gccatcttca tgtatatgat gcctcaggac aagatcatcc atgactgaga taagataatc 840 tccatgtcct atggcgtcct caccccccat gatgaacca 879

<210> 76 <211> 65 <212> PRT <213> Canis familiaris <400> 76

Trp Phe Ile Met Gly Gly Glu Asp Ala Ile Gly His Gly Asp Tyr Leu 1 5 10 15 Ile Ser Val Met Asp Asp Leu Val Leu Arg His His Ile His Glu Asp 20 25 30 Gly Arg Ala Ile Glu Glu Gly His His Cys Glu Val Arg Pro Thr Cys 35 40 45 Gly Lys Gly Leu Gly Met Ala Pro Cys Arg Pro Gln Pro Gln His Arg 50 55 60

His <210> 77 <211> 699 <212> DNA <213> Canis familiaris

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069269_0225_SL.TXT <400> 77

accgtcatca tgcccaagat gttgctcagc attgccacag ggaccaagac cattagtttt 60 gctggttgca tcacttagga ctttttccac gtcttcctgg aggctacaga gttcctcctc 120 ctcacaccca aggcctgtga ccactacatt gccatctgcc agcctctctg ctacctcagt 180 gtcatgagca acagagtctg cacacggctc atcctcacct gctggctggc aggattctcc 240 ttcatcatcg tgcctgtcat cctgaccagt catcttccat tatgcaacac ccacatcaac 300 cacttcttct gtaactatat gcctctaatg gaagtagtgt gtagcaggcc acaagtgtta 360 gaggtggtgg cttttaccct ggccattgag gcgctggtca gcactgtatt gctgatcacc 420 atatcttatg tccagatcat ccagaccatt gtaaggatcc cctctgtcca ggagagaagg 480 aaagctttct ctacctcttc ttcccatatc attgtgatca ccaggtgcta tgacagctgc 540 ttcttcatgt atgtcaagcc ctctctaggc aagggggttg atttcaacaa aggagtgtct 600 gtaatcaata caattattgc ccccctcttg aatcccttca tctatactct caggaaccaa 660 caagttaagg aagtagtgaa aaacctgatc aggaaaatg 699

<210> 78 <211> 172 <212> PRT <213> Canis familiaris <400> 78

Met Ser Asn Arg Val Cys Thr Arg Leu Ile Leu Thr Cys Trp Leu Ala 1 5 10 15 Gly Phe Ser Phe Ile Ile Val Pro Val Ile Leu Thr Ser His Leu Pro 20 25 30 Leu Cys Asn Thr His Ile Asn His Phe Phe Cys Asn Tyr Met Pro Leu 35 40 45 Met Glu Val Val Cys Ser Arg Pro Gln Val Leu Glu Val Val Ala Phe 50 55 60 Thr Leu Ala Ile Glu Ala Leu Val Ser Thr Val Leu Leu Ile Thr Ile 65 70 75 80

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Ser Tyr Val Gln Ile 85 Ile Gln 069269_0225_SL.TXT Thr Ile Val Arg Ile Pro 90 Ser Val 95 Gln Glu Arg Arg Lys Ala Phe Ser Thr Ser Ser Ser His Ile Ile Val Ile 100 105 110 Thr Arg Cys Tyr Asp Ser Cys Phe Phe Met Tyr Val Lys Pro Ser Leu 115 120 125 Gly Lys Gly Val Asp Phe Asn Lys Gly Val Ser Val Ile Asn Thr Ile 130 135 140 Ile Ala Pro Leu Leu Asn Pro Phe Ile Tyr Thr Leu Arg Asn Gln Gln 145 150 155 160 Val Lys Glu Val Val Lys Asn Leu Ile Arg Lys Met

165 170 <210> 79 <211> 648 <212> DNA <213> Canis familiaris <400> 79

atctccttcc agagctgtgt ggcccagatg tacgtcttca tggtcctggg catctcagag 60 tgctgcctcc tcacagccat ggcctatgac cactatgcag ccatctgtca gcccctgcac 120 tatgccaccc tcatgagctg gagggcctgc acggctatgg tgggtgtctc ctggctcatg 180 ggcatcgtca cagccaccac ccattccact ctcatcttca ctctgccctt ccccagccac 240 cccatcatcc tgcacttcct ctgtgacatc ctgccagtac tgaggctggc aagtgctggg 300 aaacacgaga gtgaaatctc cgtgatgaca gccaccgtgg tcttcatcat ggtccccttc 360 tctctgatca ttgcctctta tgcctgcatt ctgagtgcca acctggcaat ggcctccacc 420 cagagccgtc acaaggtctt ctctacttgc tcctcccacc tgcttgtggt cttcctcttc 480 tttggaacag ccagcatcac ctacatccag ccccggactg gctcctctgt taccatgaac 540 cgcatcctca gcctcttcta cacagtcatc acacccatgc tcaaccccat catctacacc 600 cttcgcaaca aggaggtggc aagggccctg cagcgcatgg tgaagagg 648

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069269_0225_SL.TXT <210> 80 <211> 216 <212> PRT <213> Canis familiaris <400> 80

Ile 1 Ser Phe Gln Ser Cys Val Ala Gln Met Tyr Val Phe Met Val Leu 5 10 15 Gly Ile Ser Glu Cys Cys Leu Leu Thr Ala Met Ala Tyr Asp His Tyr 20 25 30 Ala Ala Ile Cys Gln Pro Leu His Tyr Ala Thr Leu Met Ser Trp Arg 35 40 45 Ala Cys Thr Ala Met Val Gly Val Ser Trp Leu Met Gly Ile Val Thr 50 55 60 Ala Thr Thr His Ser Thr Leu Ile Phe Thr Leu Pro Phe Pro Ser His 65 70 75 80 Pro Ile Ile Leu His Phe Leu Cys Asp Ile Leu Pro Val Leu Arg Leu 85 90 95 Ala Ser Ala Gly Lys His Glu Ser Glu Ile Ser Val Met Thr Ala Thr 100 105 110 Val Val Phe Ile Met Val Pro Phe Ser Leu Ile Ile Ala Ser Tyr Ala 115 120 125 Cys Ile Leu Ser Ala Asn Leu Ala Met Ala Ser Thr Gln Ser Arg His 130 135 140 Lys Val Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Phe Leu Phe 145 150 155 160 Phe Gly Thr Ala Ser Ile Thr Tyr Ile Gln Pro Arg Thr Gly Ser Ser 165 170 175 Val Thr Met Asn Arg Ile Leu Ser Leu Phe Tyr Thr Val Ile Thr Pro

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180 185 190 Met Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys Glu Val Ala Arg 195 200 205 Ala Leu Gln Arg Met Val Lys Arg 210 215

<210> 81 <211> 666 <212> DNA <213> Canis familiaris <400> 81

ttctcacaga caccacctat cgaggcaggg gtatttgtac tatttatttt cttctatgtg 60 cccacttggg taggcaatgt cctcatcttg gtcacagtag cctctgataa ctatctgaat 120 tcatcaccca tgtatttcct tcttggcaac ccctctttcc tggacttacg ttattcaact 180 atccctaagc ttctggctga ctttcttgat aatgagaagc tcattcgcta tggccaatgc 240 attgtgcagc tcttctttct gcattttgta ggagcagttg agatgttcct gcttacagtg 300 atggcctatg atctttatgt tgcaatttgt tgccctctgc actataccac tattatgagt 360 caaggattac gctgtatgtt ggtagctgct tcctggatgg gagtgtttgt gtaatctact 420 gtccagagga tccttgctat acgtttgcct tttttgtgga ccaaaccagg tggacaactt 480 cttttgtgat gttcccccat catcaaactt gcctgtgtgg acacattatt attgattatt 540 gaattactaa tggcatctaa cagtgggtta atctctacca gttcctttat tatactgttt 600 tcttcctatt ccactatcct ggtcaagatt cgctccaagg agggaaggcg aaaggcactc 660

gccacc 666 <210> 82 <211> 137 <212> PRT <213> Canis familiaris <400> 82

Phe Ser Gln Thr Pro Pro Ile Glu Ala Gly Val Phe Val Leu Phe Ile 1 5 10 15

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Phe Phe Tyr Val Pro Thr Trp Val Gly Asn Val Leu Ile Leu Val Thr 20 25 30 Val Ala Ser Asp Asn Tyr Leu Asn Ser Ser Pro Met Tyr Phe Leu Leu 35 40 45 Gly Asn Pro Ser Phe Leu Asp Leu Arg Tyr Ser Thr Ile Pro Lys Leu 50 55 60 Leu Ala Asp Phe Leu Asp Asn Glu Lys Leu Ile Arg Tyr Gly Gln Cys 65 70 75 80 Ile Val Gln Leu Phe Phe Leu His Phe Val Gly Ala Val Glu Met Phe 85 90 95 Leu Leu Thr Val Met Ala Tyr Asp Leu Tyr Val Ala Ile Cys Cys Pro 100 105 110 Leu His Tyr Thr Thr Ile Met Ser Gln Gly Leu Arg Cys Met Leu Val 115 120 125 Ala Ala Ser Trp Met Gly Val Phe Val

130 135 <210> 83 <211> 810 <212> DNA <213> Canis familiaris <400> 83

atgtatgaat caaattattc tgatgtgttt tggtttatat ccttggcact ttctacctat 60 agaccagcac tgaattttct ccttgccttt tctccagtgt tttatgtaac agttatcctg 120 ggaaacctcc ttgttgtgtt tagagtgatg tttaccctta cttacattcc actatgtact 180 tccttttagc aaatctctca ttcattgact tgtgtctttc caccttaatg attcctaaga 240 agattcatga cctgcactca gggcacaaaa ccatatcctt ccagggatgt gtcatccatt 300 tatttgtatt tcatgtcctg ggtggatctg agatggtgct gctcattgcc atggtcttgg 360 atcgcctatg tggccatatg taagcctctc cactatctga ctatcatgag tccgcagatg 420

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069269_0225_SL.TXT tgaattttgc ttctgtctgg tgcttgggct gttggcctca ttcattcagt ggcccagtta gctttcgttg tccacttgac tttttgtggt cctaatgtga tagacagctt ttgctttgaa cttccttggt tcatcaaatg tgcctgcgca gacccttaca ggatggaatt catggtgact gccaacagca ggttcatttc catgggcgcc ttcttctcat tgcttatctc ctaagttttc atcctggtca ctctctggaa acgttcctca ggtggtttgt ctaaggcctt ttctactctg tcagcgcaca ttaaagaagc tgtgatctat gtatacaatg aaatattact cagccatcag aaatggcgaa tacccaccat ctgtctggac <210> 84 <211> 62 <212> PRT <213> Canis familiaris <400> 84

Met Tyr Glu Ser Asn Tyr Ser Asp Val Phe Trp Phe Ile Ser Leu Ala 1 5 10 15 Leu Ser Thr Tyr Arg Pro Ala Leu Asn Phe Leu Leu Ala Phe Ser Pro 20 25 30 Val Phe Tyr Val Thr Val Ile Leu Gly Asn Leu Leu Val Val Phe Arg 35 40 45 Val Met Phe Thr Leu Thr Tyr Ile Pro Leu Cys Thr Ser Phe 50 55 60

<210> 85 <211> 933 <212> DNA <213> Canis familiaris <400> 85 atgaagttgc agaattattc cttggtgtca gaatttgtgt tgtatggact ctgcacgtca cgacatctcc agcatttatt cttcatattt ttctctggga tctatgtggc cagtgtgctg ggtaacctca tcattgtggt caccataatt tctgactcac acttgcactc ctctcctatg tacttcctgc taggaaacct atctttctta gacatatggc tcgcctcctt tgccaccccc aagatgctca gggactttct tagtgaccga aagcttatct cctttggagg atgtatggct Page 95

480

540

600

660

720

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810

120

180

240

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069269_0225_SL.TXT

caaatcttct tcttgcactt tattggtggg gctgagatgg tacttctggt ttccatggcc 360 tatgacagat atgtggctat atgtaaacct ctgcattata tgactgtgat gagacggcag 420 acctgcgtgg ggctggtgtt ggtctcatgg gtcattggct ttgtgcattc catcagtcaa 480 gtagccttta ctgtgaattt accgtactgt ggccccaatg aggtggacag cttcttttgt 540 gacctgcctc ttgtaatcaa gcttgcctgc atggacacct acatcttagg tatccttatg 600 atctcagata gtggattact ctccatgagc tgctttctgc tcctcttggt ctcttacact 660 gtcatcctca tcactgtccg acagcgcact gctggtggcg tatccaaagc actctccact 720 tgctctgcac acatcatggt tgtcacactc ttctttgggc cctgcatttt catttatgtg 780 tggcctttca gccggttctc tgtggacaag ctcctgtctg tgttttacac catttttact 840 ccactcttga acccccttat ctacacactg agaaataaag agatgaaaat agctatgaag 900 aaactgtgta accaccatgt gacttctcgt tga 933

<210> 86 <211> 310 <212> PRT <213> Canis familiaris <400> 86

Met 1 Lys Leu Gln Asn 5 Tyr Ser Leu Val Ser Glu Phe Val Leu Tyr Gly 10 15 Leu Cys Thr Ser Arg His Leu Gln His Leu Phe Phe Ile Phe Phe Ser 20 25 30 Gly Ile Tyr Val Ala Ser Val Leu Gly Asn Leu Ile Ile Val Val Thr 35 40 45 Ile Ile Ser Asp Ser His Leu His Ser Ser Pro Met Tyr Phe Leu Leu 50 55 60 Gly Asn Leu Ser Phe Leu Asp Ile Trp Leu Ala Ser Phe Ala Thr Pro 65 70 75 80 Lys Met Leu Arg Asp Phe Leu Ser Asp Arg Lys Leu Ile Ser Phe Gly 85 90 95

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Gly Cys Met Ala 100 Gln Ile Phe Phe Leu His Phe Ile Gly Gly Ala Glu 105 110 Met Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Lys Pro Leu His Tyr Met Thr Val Met Arg Arg Gln Thr Cys Val Gly 130 135 140 Leu Val Leu Val Ser Trp Val Ile Gly Phe Val His Ser Ile Ser Gln 145 150 155 160 Val Ala Phe Thr Val Asn Leu Pro Tyr Cys Gly Pro Asn Glu Val Asp 165 170 175 Ser Phe Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Met Asp 180 185 190 Thr Tyr Ile Leu Gly Ile Leu Met Ile Ser Asp Ser Gly Leu Leu Ser 195 200 205 Met Ser Cys Phe Leu Leu Leu Leu Val Ser Tyr Thr Val Ile Leu Ile 210 215 220 Thr Val Arg Gln Arg Thr Ala Gly Gly Val Ser Lys Ala Leu Ser Thr 225 230 235 240 Cys Ser Ala His Ile Met Val Val Thr Leu Phe Phe Gly Pro Cys Ile 245 250 255 Phe Ile Tyr Val Trp Pro Phe Ser Arg Phe Ser Val Asp Lys Leu Leu 260 265 270 Ser Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Leu Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Glu Met Lys Ile Ala Met Lys Lys Leu Cys Asn 290 295 300

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His His Val Thr Ser Arg 305 310 <210> 87 <211> 909 <212> DNA <213> Canis familiaris <400> 87

atgagaaacc attcaacaga aatagagttt attctcataa gactgacgga tgacccacaa 60 ttgcaagttg tgatttttgt gtttttattt cttaattaca cattgagcct gatggggaac 120 ttaaccatta tcctactcac tctgctggat cctcacctca agatgccaat gtatttcttt 180 ctctgtaatt tctcattttt agaaatcata ttcacaacgg tatgtattcc cagatacttg 240 aaaaccatag tgactaaaga acaaaacgtt tcatataata actgtgtggc tcaattattt 300 tttattcttt tactgggagt tgcagagttt taccttctgg ctgctatgtc ctatgaccgc 360 tatgtggcca tctgtaaacc cttgcattac ccaatcatta tgaacagcag agtgtgctat 420 tggcttgtac tttcttcttg gctgactgga ttcctaatca tctttccacc attgctcatg 480 ggactcaagc tggatttctg tgcttccaaa acgattgatc actttatgtt tcccccatcc 540 tgcagatatc ctgcacagac acacacacaa ttttatgtcc tagaattgat gtctttcatc 600 ttcgctgtgg tgacacttgt ggtcacattg gtgttagtgg atctctccta cacttgcatc 660 atgaagacca ttatgaaatt cccttctgca cagcaaagga ccaaagcttt ttccacctgt 720 acttcccata tgattgttgt ctccatgaca tatgggagct acatctttat gtatattaag 780 ccatctgcca aagaaagggt gactgtatcc aaagatgtag ctttgctgta tacctcaatt 840 gcccctttac taaatccctt catttatatc ctaaggaacc agcaggtgaa cgaaatcttt 900

tgctcctaa 909 <210> 88 <211> 302 <212> PRT <213> Canis familiaris <400> 88

Met Arg Asn His Ser Thr Glu Ile Glu Phe Ile Leu Ile Arg Leu Thr Page 98

0 6926 9_02 25_S L.TX T 1 5 10 15 Asp Asp Pro Gln Leu Gln Val Val Ile Phe Val Phe Leu Phe Leu Asn 20 25 30 Tyr Thr Leu Ser Leu Met Gly Asn Leu Thr Ile Ile Leu Leu Thr Leu 35 40 45 Leu Asp Pro His Leu Lys Met Pro Met Tyr Phe Phe Leu Cys Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ile Phe Thr Thr Val Cys Ile Pro Arg Tyr Leu 65 70 75 80 Lys Thr Ile Val Thr Lys Glu Gln Asn Val Ser Tyr Asn Asn Cys Val 85 90 95 Ala Gln Leu Phe Phe Ile Leu Leu Leu Gly Val Ala Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Pro Ile Ile Met Asn Ser Arg Val Cys Tyr Trp Leu Val Leu 130 135 140 Ser Ser Trp Leu Thr Gly Phe Leu Ile Ile Phe Pro Pro Leu Leu Met 145 150 155 160 Gly Leu Lys Leu Asp Phe Cys Ala Ser Lys Thr Ile Asp His Phe Met 165 170 175 Phe Pro Pro Ser Cys Arg Tyr Pro Ala Gln Thr His Thr Gln Phe Tyr 180 185 190 Val Leu Glu Leu Met Ser Phe Ile Phe Ala Val Val Thr Leu Val Val 195 200 205 Thr Leu Val Leu Val Asp Leu Ser Tyr Thr Cys Ile Met Lys Thr Ile

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210

215

069269_0225_SL.TXT

220

Met 225 Lys Phe Pro Ser Ala 230 Gln Gln Arg Thr Lys Ala Phe Ser Thr Cys 235 240 Thr Ser His Met Ile Val Val Ser Met Thr Tyr Gly Ser Tyr Ile Phe 245 250 255 Met Tyr Ile Lys Pro Ser Ala Lys Glu Arg Val Thr Val Ser Lys Asp 260 265 270 Val Ala Leu Leu Tyr Thr Ser Ile Ala Pro Leu Leu Asn Pro Phe Ile 275 280 285 Tyr Ile Leu Arg Asn Gln Gln Val Asn Glu Ile Phe Cys Ser

290 295 300 <210> 89 <211> 645 <212> DNA <213> Canis familiaris <400> 89

caattgtttt ttaccttcct tcttggtgca tctgaacttt gtttgctggc agctatgtcc 60 tatgaccact atgttgccat ttgtaagcac ctgcattaca caaccatcat gagcagtaag 120 atctgcacac aagttgtctt ctgttgtcgg tttgctgggt cttttgtcat ctttccacct 180 ctcctcttag acttaaatct tggcttctat gccttcaaca ttgttgatca tttctactgt 240 gccacaaccc ccctgctgca gatctcctgc ttagacacac agctcttaga gacaatggga 300 tacatctctg ctttggtgac actcacagtc acattggtaa tggtgataat atcatatacc 360 tacattgtat taagaattct aaaaatcttt tcagtcaatc agaggaaaaa ggctttttca 420 acatgttctt ctcacatgac tgtgatatcc ctttcttatg gcagctgcat cttcatgtat 480 gttaagccat cagccaaaca aagaacatct tattccaagg gaattgcagt gctcaacacg 540 tctgttgctc tacttttgaa tcctttcatc tacactttgt ggaacaagca agtaaaaaca 600 gccttcatga acatggtaca caaaattgtt tctttctcga acaaa 645

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069269_0225_SL.TXT <210> 90 <211> 215 <212> PRT <213> Canis familiaris <400> 90

Gln Leu Phe Phe Thr Phe Leu Leu Gly Ala Ser Glu 10 Leu Cys Leu 15 Leu 1 5 Ala Ala Met Ser Tyr Asp His Tyr Val Ala Ile Cys Lys His Leu His 20 25 30 Tyr Thr Thr Ile Met Ser Ser Lys Ile Cys Thr Gln Val Val Phe Cys 35 40 45 Cys Arg Phe Ala Gly Ser Phe Val Ile Phe Pro Pro Leu Leu Leu Asp 50 55 60 Leu Asn Leu Gly Phe Tyr Ala Phe Asn Ile Val Asp His Phe Tyr Cys 65 70 75 80 Ala Thr Thr Pro Leu Leu Gln Ile Ser Cys Leu Asp Thr Gln Leu Leu 85 90 95 Glu Thr Met Gly Tyr Ile Ser Ala Leu Val Thr Leu Thr Val Thr Leu 100 105 110 Val Met Val Ile Ile Ser Tyr Thr Tyr Ile Val Leu Arg Ile Leu Lys 115 120 125 Ile Phe Ser Val Asn Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser 130 135 140 His Met Thr Val Ile Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met Tyr 145 150 155 160 Val Lys Pro Ser Ala Lys Gln Arg Thr Ser Tyr Ser Lys Gly Ile Ala 165 170 175 Val Leu Asn Thr Ser Val Ala Leu Leu Leu Asn Pro Phe Ile Tyr Thr 180 185 190

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Leu Trp Asn Lys Gln Val Lys Thr Ala Phe Met Asn Met Val His Lys 195 200 205

Ile Val Ser Phe Ser Asn Lys 210 215 <210> 91 <211> 891 <212> DNA <213> Canis familiaris <400> 91

gaaaactgta caactgtgac agtatttatc ttagcaggat tgatggagga cccaaaactg 60 aagattgtgc tatttgtctt cctgctcctc acctgcttgc taagaatctc aggcaactta 120 gttattatta ccctcacttt gctggactca catctcaaga cccctatgta tttctttctt 180 tgaaattttt ctttcttaga aatttcttat acgacagtct gcatccccaa attgcttgta 240 agcatggcaa ctgatgacaa aaccatttcc tataactgtt gtgcaactca gttgtttgcc 300 ttccttcttg gagcatctga atgttacctc ctggctgtca tgtcctacga tcattatgtc 360 accatctgca agcccctgca ttacacaacc attatgagca gcaaaatctg tatccagcta 420 gtccttagct cttggatcac tggtttcctc atcatctttc ccaggactca ttttaggctt 480 aagcctggac ttctgtgatt ccaatgtcat tgatcatttc tactgtgaca ctgctcccct 540 cctgcagatc tcctgcatgg acagacatgt gttggaaatg atgagtttca tcttagcttt 600 ggtgactctg ctggtcactt tggcattagt aattctatca tacacatata ttgccctgac 660 aattttaaaa tttccttctg ccaaccagag aaaaaagctt tctccacctg ttcttctcac 720 atgattgtca tctccctctc atatggcagc tgcatcttta tgtaccttaa accctcagtc 780 aaacagagga tatccttgaa gaagggagtg gcagttctca atacttctgt tgctccactt 840 ttgaatccct ttatttatac tctaaggaaa cagcaggtga agcaagcatt t 891

<210> 92 <211> 83 <212> PRT <213> Canis familiaris

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<400> 92 Lys Leu Tyr Asn 1 Cys 5 Asp Ser Ile Tyr Leu Ser Arg Ile Asp Gly Gly 10 15 Pro Lys Thr Glu Asp Cys Ala Ile Cys Leu Pro Ala Pro His Leu Leu 20 25 30 Ala Lys Asn Leu Arg Gln Leu Ser Tyr Tyr Tyr Pro His Phe Ala Gly 35 40 45 Leu Thr Ser Gln Asp Pro Tyr Val Phe Leu Ser Leu Lys Phe Phe Phe 50 55 60 Leu Arg Asn Phe Leu Tyr Asp Ser Leu His Pro Gln Ile Ala Cys Lys 65 70 75 80

His Gly Asn <210> 93 <211> 780 <212> DNA <213> Canis familiaris <400> 93

atgatgggaa accagacatc agtgatagaa ttcattcttc ttggactgac gaatgacact 60 gagcttcaag ctgtgctttt cctttttctg ctgctaactt atgtcttaag catcatggga 120 aacttgacca tcatcattct ggcccttttg gattatcgcc ttcagactcc tatgtatttc 180 tttttccgga atttttctgt tttggaagta tcttttactt ctgtctttgt tcccaaaatg 240 ctagtcaata ttgcaactgg agacaagact atctccttcg ctggttgttt cactcagaat 300 ttttttgcca tccttctggg gcaactgaat tttatctttt agctgccatg tcctatgatt 360 gctatgttgc catttgtaaa cccttgcatt atacaactgt aatgagcagg aaactgcatt 420 cagcttgttc tgtgttcctg gttctctggt tttttggttg tcattgtgcc acatacaatg 480 actctccaac tgcctttctg tgtctccaat gtcatcaatc attgatgctg tgactatccc 540 atactgctgc atctgtcctg ttcagacaca cagttcatag aagtgatgga atttatcttt 600 gctacagtta ccctcatctt caccttggtg ctagtgattc tttcctacac gtacataatc 660

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069269_0225_SL.TXT aggacaattc tgagaatccc ttctgttcaa caaagaaaaa aaagcctttt ctacatgctc ctgtcacatg attgtggtct cactttcata tggaagttgt atctttatgt acataaatcc

720

780 <210> 94 <211> 113 <212> PRT <213> Canis familiaris <400> 94

Met Met Gly Asn Gln Thr Ser Val Ile Glu Phe Ile Leu Leu Gly Leu 1 5 10 15 Thr Asn Asp Thr Glu Leu Gln Ala Val Leu Phe Leu Phe Leu Leu Leu 20 25 30 Thr Tyr Val Leu Ser Ile Met Gly Asn Leu Thr Ile Ile Ile Leu Ala 35 40 45 Leu Leu Asp Tyr Arg Leu Gln Thr Pro Met Tyr Phe Phe Phe Arg Asn 50 55 60 Phe Ser Val Leu Glu Val Ser Phe Thr Ser Val Phe Val Pro Lys Met 65 70 75 80 Leu Val Asn Ile Ala Thr Gly Asp Lys Thr Ile Ser Phe Ala Gly Cys 85 90 95 Phe Thr Gln Asn Phe Phe Ala Ile Leu Leu Gly Gln Leu Asn Phe Ile 100 105 110

Phe <210> 95 <211> 507 <212> DNA <213> Canis familiaris <400> 95 tcctatttta gtggctacat cagctcggtt cttcagacga gtatgacatt tactttgtcc

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ttttgtgctt cccgagccat cgaccacttt tactgtgatg accgtccact tcaaaggatt 120 acttgctctg atctctactt tcataggata gtttcctttc ccttatgcag cattattatt 180 ttacctacca tcattgtcat tctcatgtcc tatatgtata ttgtgtccac agttctaaag 240 ataagatcca ctgagggatg taagaaagcc ttctccactt gcagctctca cctaggagtc 300 gtgagcatcc tgtacggtgc catcattttt atgtatttca tccctgacag attccctgaa 360 ctaagtaaag tggctcctta tgttatacgt tagtcactct catgttgaat cctttgattt 420 actccctgag aaacaaagat gtcaaagagg ctctgagaaa gatcctgggg aaaaatattt 480 ttatttaatt ctatattaac agtgata 507 <210> 96 <211> 130 <212> PRT <213> Canis familiaris <400> 96 Ser Tyr Phe Ser Gly Tyr Ile Ser Ser Val Leu Gln Thr Ser Met Thr 1 5 10 15 Phe Thr Leu Ser Phe Cys Ala Ser Arg Ala Ile Asp His Phe Tyr Cys 20 25 30 Asp Asp Arg Pro Leu Gln Arg Ile Thr Cys Ser Asp Leu Tyr Phe His 35 40 45 Arg Ile Val Ser Phe Pro Leu Cys Ser Ile Ile Ile Leu Pro Thr Ile 50 55 60 Ile Val Ile Leu Met Ser Tyr Met Tyr Ile Val Ser Thr Val Leu Lys 65 70 75 80 Ile Arg Ser Thr Glu Gly Cys Lys Lys Ala Phe Ser Thr Cys Ser Ser 85 90 95 His Leu Gly Val Val Ser Ile Leu Tyr Gly Ala Ile Ile Phe Met Tyr 100 105 110 Phe Ile Pro Asp Arg Phe Pro Glu Leu Ser Lys Val Ala Pro Tyr Val

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115 120 125

Ile Arg 130 <210> 97 <211> 255 <212> DNA <213> Canis familiaris <400> 97 ctgatggatg acccaaagtg gcaggtcgta cttttcatat ttcttcttgt tacctacatg 60 ttcagtgtga ctgggaacct ggtcattatc atcctcacac taacagatcc ccacctgaag 120 actctaatgt atttcttcct tcgaaacttc tcattcctag aaatgtcatt cacatctgtt 180 gcaattccca gattccttgt cactgttgtg acgggagaca aaaccatttc ctacaatgac 240 tgtctgggaa acata 255 <210> 98 <211> 85 <212> PRT <213> Canis familiaris <400> 98

Leu Met Asp Asp Pro Lys Trp Gln Val Val Leu Phe Ile Phe Leu Leu 1 5 10 15 Val Thr Tyr Met Phe Ser Val Thr Gly Asn Leu Val Ile Ile Ile Leu 20 25 30 Thr Leu Thr Asp Pro His Leu Lys Thr Leu Met Tyr Phe Phe Leu Arg 35 40 45 Asn Phe Ser Phe Leu Glu Met Ser Phe Thr Ser Val Ala Ile Pro Arg 50 55 60 Phe Leu Val Thr Val Val Thr Gly Asp Lys Thr Ile Ser Tyr Asn Asp 65 70 75 80 Cys Leu Gly Asn Ile 85

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069269_0225_SL.TXT <210> 99 <211> 873 <212> DNA <213> Canis familiaris <400> 99

atgttagcga tgaaaaacca aacccttctg acagaattca ttctgctggg actaacagaa 60 atcccagaga tccaacttgt agtctttcta tttctcttcc tcacctacat attcagcatc 120 attggaaacc tcacaatcat cacacttaca ctactggact cacacctcca gactcccatg 180 tatttcttcc tccggaattt ctccttccta gaaatttcct ttacaaccac ctttactcct 240 aggctgctgt tcagcatcac aactggcaac aagagcatta gctttgctgg ctgcttcact 300 cagtatttct ttgccacctt ctttggagcc acagagtttt accttctggc tgccatgtcc 360 tatgaccgct atgtggctat atgcaaaccc ctgcattaca tgaccattat gagcaacagt 420 ctgcattcag ctggttctct gctcttggtt ggctggattt ctaatcatca tatccccaat 480 catcctgacc agtcagctgg atttctgtgc ctccaacata ctgaatcatt attattgtga 540 ctacggaccc ctgctagaaa tatcttgctc agacacaaga ctcttagaac tggttgactt 600 tatcttagca gctgtgacct tggtggtcac cctggtgctg gtggttctct cctacacaaa 660 catcatctgg accatcctca agatcccctc gctcagcaaa ggaaaaaggc cttttccaca 720 tgttcttccc acatgattgt cattgccctc tcttatggca gttgcatctt catgtatata 780 aaaccctcag ccaaagaagg agttgccttc aataaggggg tagctgtgct caatacctca 840 ttgccccttt attgaaccca ttcatttaca ctt 873

<210> 100 <211> 179 <212> PRT <213> Canis familiaris <400> 100

Met Leu Ala Met Lys Asn Gln Thr Leu Leu Thr Glu Phe Ile Leu Leu 1 5 10 15

Gly Leu Thr Glu Ile Pro Glu Ile Gln Leu Val Val Phe Leu Phe Leu 20 25 30

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Phe Leu Thr Tyr Ile Phe Ser Ile Ile Gly Asn Leu Thr Ile Ile Thr 35 40 45 Leu Thr Leu Leu Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu 50 55 60 Arg Asn Phe Ser Phe Leu Glu Ile Ser Phe Thr Thr Thr Phe Thr Pro 65 70 75 80 Arg Leu Leu Phe Ser Ile Thr Thr Gly Asn Lys Ser Ile Ser Phe Ala 85 90 95 Gly Cys Phe Thr Gln Tyr Phe Phe Ala Thr Phe Phe Gly Ala Thr Glu 100 105 110 Phe Tyr Leu Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Lys Pro Leu His Tyr Met Thr Ile Met Ser Asn Ser Leu His Ser Ala 130 135 140 Gly Ser Leu Leu Leu Val Gly Trp Ile Ser Asn His His Ile Pro Asn 145 150 155 160 His Pro Asp Gln Ser Ala Gly Phe Leu Cys Leu Gln His Thr Glu Ser 165 170 175

Leu Leu Leu <210> 101 <211> 939 <212> DNA <213> Canis familiaris <400> 101 atgaaaaact atacagcaat aacaacattc atcttggtgg gattaacaaa tgacccacat ctacagattc tgctttttat ttttctattt ctaacctact tgttgagtgt tgtagggaat ctgaccatta tcagcctcac gttggtggat tcccacctta aaacacccat gtattttttc Page 108

120

180

069269_0225_SL.TXT ctccggaatt tctccatctt ggaagtgttc tacacaatgg catctgggga caataccgtt tttgttgtca tattgggtgt gactgaattt tatgtggcca tctgcaaacc cctgcattac aagtttctta ttggatgtta tatgttagct ggcttcaagc tcgagttttg tgactccaat cccatcctga agattacctg ctcagacaca gctgtgttga cactcatttt caccttggtg aggaccattc tcagatttcc ttctgtccag tcccatataa ttgtggtttc tattacttat catgcaaaag aaggggttgc tattaataag ccagtgatga atccctttat ttatactctg gacatgatca aaagagttgc atctatctca <210> 102 <211> 312 <212> PRT <213> Canis familiaris <400> 102 tttaccactg tctgcattcc tagattcctc acctacaatg catgtgccac tcaattattt ttcctcctca cagccatgtc ctatgaccgc atgactatca tgaacaacag ggtctgcatc ctgctcatcg tcctcccacc ctatatcatg gtcatagatc actttggctg tgacgctgct gagtttattg agcgatttgt cttggtcctg tgtgtaattc tgtcctacac atacatcatc caaaggaaaa aggctttttc tacttgttct ggaagctgca tctttatcta tatcaaacct gtggtgtcag tgcttaccac ctcagttgcc aggaacaagc aagtggtaca agctttcaaa aagaattaa

240

300

360

420

480

540

600

660

720

780

840

900

939

Met 1 Lys Asn Tyr Thr 5 Ala Ile Thr Asn Asp Pro His 20 Leu Gln Ile Leu Tyr Leu Leu 35 Ser Val Val Gly Asn 40 Val Asp 50 Ser His Leu Lys Thr 55 Pro Ser 65 Ile Leu Glu Val Phe 70 Phe Thr

Thr Phe 10 Ile Leu Val Gly Leu 15 Thr Leu 25 Phe Ile Phe Leu Phe 30 Leu Thr Leu Thr Ile Ile Ser 45 Leu Thr Leu Met Tyr Phe Phe 60 Leu Arg Asn Phe Thr Val Cys 75 Ile Pro Arg Phe Leu 80

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Tyr Thr Met Ala Ser 85 Gly Asp Asn Thr Val 90 Thr Tyr Thr Gln Leu Phe Phe Val Val Ile Leu Gly Val Thr 100 105 Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile 115 120 His Tyr Met Thr Ile Met Asn Asn Arg Val Cys Ile 130 135 140 Gly Cys Tyr Met Leu Ala Leu Leu Ile Val Leu Pro 145 150 155 Gly Phe Lys Leu Glu Phe Cys Asp Ser Asn Val Ile 165 170 Cys Asp Ala Ala Pro Ile Leu Lys Ile Thr Cys Ser 180 185 Ile Glu Arg Phe Val Leu Val Leu Ala Val Leu Thr 195 200 Leu Val Cys Val Ile Leu Ser Tyr Thr Tyr Ile Ile 210 215 220 Arg Phe Pro Ser Val Gln Gln Arg Lys Lys Ala Phe 225 230 235 Ser His Ile Ile Val Val Ser Ile Thr Tyr Gly Ser 245 250 Tyr Ile Lys Pro His Ala Lys Glu Gly Val Ala Ile 260 265 Ser Val Leu Thr Thr Ser Val Ala Pro Val Met Asn 275 280

Asn Ala Cys Ala 95

Glu Phe Phe Leu 110

Cys Lys Pro Leu 125

Lys Phe Leu Ile

Pro Tyr Ile Met 160

Asp His Phe Gly 175

Asp Thr Glu Phe 190

Leu Ile Phe Thr 205

Arg Thr Ile Leu

Ser Thr Cys Ser 240

Cys Ile Phe Ile 255

Asn Lys Val Val 270

Pro Phe Ile Tyr 285

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Thr Leu Arg Asn Lys Gln Val Val Gln Ala Phe Lys Asp Met Ile Lys 290 295 300

Arg Val Ala Ser Ile Ser Lys Asn

305 310 <210> 103 <211> 945 <212> DNA <213> Canis familiaris <400> 103

atgagaaacc acacagaact aacagacttt atcctcctgg gattgtcaga tgacccacag 60 cttcaggagg tgatctttgt ctttctgctc atcacctaca ttctcagcat cactgggaac 120 ctgaccatta tcaccctcac cctgctggat tcccacctcc agacccccat gtatttcttc 180 ctcagaaact tctccttact cgagatttca ttcacaactg tgagcgtacc caagttcctg 240 ggcaccctga ttacaggaga taaaactgtt tcctttaatg attgtatggc tcagttattt 300 tttgttattt ttttcattct gttgggagtc actgaatttt acctgctggc tgccatgtcc 360 tgtgactgat acattgccat cggcaaacct ctgcattaca tgaccatcat gaatcccaga 420 gtctgcatac tccttgtctt tgcttcttgg tcggcttcat tcttaatcat attcccatca 480 ctcatgctgt tcatacagct tgattattgt aagtccaatg ctatagacca ttttacctgt 540 gactatttcc ccttactaca tctttcttgt tcagacacta gattcttaga gatagtgggt 600 ttttcctgtg ctgtttttac gttaatgttc acattggtga taataattct gtcctacata 660 tatatcctca gaacaatttt gaagattcct tctactagtc agaggacaaa ggccttttcc 720 atctgttctt cccacatgat tgtcatctct atctcctatg gcagctgcat tttcatgtat 780 attaacccag cagcaaaaga cagagtgtct ctgagcaagg gagttgctgt gctaaacacc 840 tcggtagccc ccatgctgaa cccctttatt tacagcctaa ggaaccagca agtcaagcaa 900 gccttactgg acagggcaag gaagattgta tttttctcaa gcaaa 945

<210> 104 <211> 182 <212> PRT

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069269_0225_SL.TXT <213> Canis familiaris <400> 104

Met Thr Ile Met Asn Pro Arg Val Cys Ile Leu Leu Val Phe Ala Ser 1 5 10 15 Trp Ser Ala Ser Phe Leu Ile Ile Phe Pro Ser Leu Met Leu Phe Ile 20 25 30 Gln Leu Asp Tyr Cys Lys Ser Asn Ala Ile Asp His Phe Thr Cys Asp 35 40 45 Tyr Phe Pro Leu Leu His Leu Ser Cys Ser Asp Thr Arg Phe Leu Glu 50 55 60 Ile Val Gly Phe Ser Cys Ala Val Phe Thr Leu Met Phe Thr Leu Val 65 70 75 80 Ile Ile Ile Leu Ser Tyr Ile Tyr Ile Leu Arg Thr Ile Leu Lys Ile 85 90 95 Pro Ser Thr Ser Gln Arg Thr Lys Ala Phe Ser Ile Cys Ser Ser His 100 105 110 Met Ile Val Ile Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met Tyr Ile 115 120 125 Asn Pro Ala Ala Lys Asp Arg Val Ser Leu Ser Lys Gly Val Ala Val 130 135 140 Leu Asn Thr Ser Val Ala Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu 145 150 155 160 Arg Asn Gln Gln Val Lys Gln Ala Leu Leu Asp Arg Ala Arg Lys Ile 165 170 175 Val Phe Phe Ser Ser Lys

180 <210> 105

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069269_0225_SL.TXT <211> 681 <212> DNA <213> Canis familiaris <400> 105

ttctgaaata tctgcatacc cttgattaac aatacagtta cctataatcc ttgtgccact 60 caattatttt ttgttattgt cttgggtgtg actgaaattt gcctcctcac agccatgtcc 120 tatgaccact atgtggccat ctgcaaaccc ctgcattaca tgaccatcat gaacaacagg 180 ctctgcatca agttccttat tggatgttat atgttagctt tgctcatcat cctcctaccc 240 tatatcatga gcttcaagct cgagttttgt gactccaatg tcatagatca ctatggctgt 300 gatgctgctc ccatcctgaa gattacctgc tcagacacag agtttattga gcgatttgtc 360 ttggtcctcg ttgtgttgac actcattttc accttggtgt gtgtaattct gtcctacaca 420 tacatcatca ggaccattct cagatttcct tctgtctttt gtcctaaaaa aaaaaaaaag 480 gctttttcta cttgatattc ccatataatt gtggtttcta ttacttatgg aagctgcaac 540 tttatctata tcaaacctca tgcaaaagaa ggggttgcta ttaataaggt ggtgtcagtg 600 cttaccacct cagttgcccc agtgatgaat ccctttattt atactctgag gaacaagcaa 660 gtggtacaag ctttcaaaga a 681

<210> 106 <211> 23 <212> PRT <213> Canis familiaris <400> 106

Phe Phe Glu Ser Leu Tyr His Leu Leu Val Pro Gln Ser Ile Asn Lys 1 5 10 15

Gly Ile His His Trp Gly Asn 20 <210> 107 <211> 996 <212> DNA <213> Canis familiaris <400> 107 atggttagat ttcaaaagtc agtgatgaga aactatacag caataacaac ttttatcctg 60

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ctgggtctga cagacgaccc acaactgcaa atcctgctct ttatctttat atttctcacc 120 tacatcttga gcgtaacagg aaacctgact attatcaccc tcacactggt gaactcccat 180 cttaaaactc ctatgtactt ttttctgaga aatttctcct tcttagaagt gtcattcacc 240 actgtctgca ttcctagatt cctgtatagt atatcaacag gggacaatac tattacctac 300 aatgcttgtg caagtcaaat attttttttg ttatgcaagt caaatatttt ttttgttatt 360 ctctttggat caactgaatt ttttctcctg gccgccatgt cctatgatcg ctatgttgct 420 atctgtaaac cacttcatta catgaccatc atgagcaata gggtgtgtag cttattagtc 480 ttctgctgtt gggtgtctgg cttgatgatc attctcccac cccctagctt gtgcctccag 540 ctggaatttt gtgactccaa tgccattgat cattttagct gtgatgcagc tcccctcctg 600 aagatctcat gttcagatac atggatgata gaacaaatgg ttatccttgt ggctgtattt 660 gcactcatta tcaccttagt gtgtgtattt ctgtcctaca catacatcat caggaccatt 720 ctgagattcc cctctgtcca acaaagaaaa aaggcctttt ccacctgctc atcccacatg 780 attgtagttt ccatcaccta tggaagcggc atcttcatct atatcaagcc atcagcaaaa 840 gaagggatag ccataaataa aggtgtttcg gtgctcacta cttctgttgc acccttgctg 900 aaccccttct tttacacctt aagaaataag caagtgaaac aagcttttaa tgacttcata 960 aagaagatga catttcactc aaagaaactg aagttt 996

<210> 108 <211> 332 <212> PRT <213> Canis familiaris <400> 108

Met Val Arg Phe Gln Lys Ser Val Met Arg Asn Tyr Thr Ala Ile Thr 1 5 10 15 Thr Phe Ile Leu Leu Gly Leu Thr Asp Asp Pro Gln Leu Gln Ile Leu 20 25 30 Leu Phe Ile Phe Ile Phe Leu Thr Tyr Ile Leu Ser Val Thr Gly Asn 35 40 45 Leu Thr Ile Ile Thr Leu Thr Leu Val Asn Ser His Leu Lys Thr Pro

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50 55 60

Met 65 Tyr Phe Phe Leu Arg Asn Phe Ser Phe Leu Glu Val Ser Phe Thr 70 75 80 Thr Val Cys Ile Pro Arg Phe Leu Tyr Ser Ile Ser Thr Gly Asp Asn 85 90 95 Thr Ile Thr Tyr Asn Ala Cys Ala Ser Gln Ile Phe Phe Leu Leu Cys 100 105 110 Lys Ser Asn Ile Phe Phe Val Ile Leu Phe Gly Ser Thr Glu Phe Phe 115 120 125 Leu Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro 130 135 140 Leu His Tyr Met Thr Ile Met Ser Asn Arg Val Cys Ser Leu Leu Val 145 150 155 160 Phe Cys Cys Trp Val Ser Gly Leu Met Ile Ile Leu Pro Pro Pro Ser 165 170 175 Leu Cys Leu Gln Leu Glu Phe Cys Asp Ser Asn Ala Ile Asp His Phe 180 185 190 Ser Cys Asp Ala Ala Pro Leu Leu Lys Ile Ser Cys Ser Asp Thr Trp 195 200 205 Met Ile Glu Gln Met Val Ile Leu Val Ala Val Phe Ala Leu Ile Ile 210 215 220 Thr Leu Val Cys Val Phe Leu Ser Tyr Thr Tyr Ile Ile Arg Thr Ile 225 230 235 240 Leu Arg Phe Pro Ser Val Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys 245 250 255 Ser Ser His Met Ile Val Val Ser Ile Thr Tyr Gly Ser Gly Ile Phe

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260

069269_0225_SL.TXT 265 270

Ile Tyr Ile Lys Pro Ser Ala Lys Glu Gly Ile Ala Ile Asn Lys Gly 275 280 285 Val Ser Val Leu Thr Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Phe 290 295 300 Tyr Thr Leu Arg Asn Lys Gln Val Lys Gln Ala Phe Asn Asp Phe Ile 305 310 315 320 Lys Lys Met Thr Phe His Ser Lys Lys Leu Lys Phe 325 330

<210> 109 <211> 933 <212> DNA <213> Canis familiaris <400> 109

atgagaaatc acacagcaat aacattcatc ttgttgggac ttacagagga cccacagctg 60 caagttcttc ttttttatct tcttatttct cagctacgtg ctgagcatta ctggaaattt 120 gaccattatc attcttacat ttatggattc tcatcttaaa acacctatgt attttttttc 180 tccacaattt ctccatctta gaaatctcat tcacaacagt atgcattccc agattcttgt 240 acagtataac aactggagac aaaactatta cgttataatg cttgtgcttg ccaaatattt 300 tttattgggc tttttggggt cacagaattt tttctcctgg cagccatgtc ctatgaccgc 360 tatgtggcca tctgcaaacc ccttcattac atgaccatca tgaataacaa agtctgtacc 420 atccttgtcc actgttgctg gatttctgtg ctgctgatca tcatcacacc ccttggtatg 480 ggcctccagc tggaattctg tgactccaat gccactgatc attttggctg tgatgcatct 540 cctcttttta agatttcatg ctcggataca tgggttatag aacagatggt tataatctgt 600 gcagtactga cattcattat tacactgggt gtcattcttt cctatatata tatcatcagg 660 acaattctaa gattttcttc tgcttctcaa agaaaaaaag ctttctccac ctgttcttca 720 cacatgcttg ttgtttccat tacatacggc agctgtattt tcatctatat caagccttct 780 gccaaagaag aggtgaatat caataaaggg gtatccgtgc tcactatatg tgttgctcct 840

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069269_0225_SL.TXT ttgttgaacc ctttcattta tactttgagg aacaagcaag tgaaacgagc tttcaatgac acaaccaaaa aaattgcatt tatcttacac aaa

900

933 <210> 110 <211> 196 <212> PRT <213> Canis familiaris <400> 110

Met Ser 1 Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr 15 Met 5 10 Thr Ile Met Asn Asn Lys Val Cys Thr Ile Leu Val His Cys Cys Trp 20 25 30 Ile Ser Val Leu Leu Ile Ile Ile Thr Pro Leu Gly Met Gly Leu Gln 35 40 45 Leu Glu Phe Cys Asp Ser Asn Ala Thr Asp His Phe Gly Cys Asp Ala 50 55 60 Ser Pro Leu Phe Lys Ile Ser Cys Ser Asp Thr Trp Val Ile Glu Gln 65 70 75 80 Met Val Ile Ile Cys Ala Val Leu Thr Phe Ile Ile Thr Leu Gly Val 85 90 95 Ile Leu Ser Tyr Ile Tyr Ile Ile Arg Thr Ile Leu Arg Phe Ser Ser 100 105 110 Ala Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser His Met Leu 115 120 125 Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile Tyr Ile Lys Pro 130 135 140 Ser Ala Lys Glu Glu Val Asn Ile Asn Lys Gly Val Ser Val Leu Thr 145 150 155 160

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069269_0225_SL.TXT Ile Cys Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr Thr Leu Arg Asn 165 170 175

Lys Gln Val Lys Arg Ala Phe Asn Asp Thr Thr Lys Lys Ile Ala Phe 180 185 190

Ile Leu His Lys 195 <210> 111 <211> 939 <212> DNA <213> Canis familiaris <400> 111

atgagaaacc aaacggcact aacaactttc atcttgctgg gactcacaga ggaccctcaa 60 ctaaaaattt tgctttttat gtttctgttt ctttcctaca tgttgaatgt atctggaaac 120 ctaaccatca tcatcctcac tctgattgat tcccacctta aaacaccaat gtatcttttc 180 ctccaaaatt tctccttcct agaaatttca ttcacaactg cttgtgtccc cagattttta 240 tatagcatat catcagggga caaatccatt acctataatg cttgtgtcag tcaactgttg 300 tttacagacc tctttgcagt aacagaattt tttctcttgg ccactatgtc ctatgatcgc 360 tatgtggcca tctgcaaacc cctgcattac atgaccatca tgagcagaag agtctgcaag 420 aacttcatcg tcttctgttg ggtagcagca ctgatcatca ttctcccacc aattagtcta 480 ggtttgggcc tggaattctg tgattcaaac atcattgatc atttttgttg tgatgcatct 540 cctatcctga agatctcttg ctcagacaca tggttgatag aacagatggt tatagtctgt 600 gctgtgttga cattcatcat caccctcatg tgtgtagttc tttcttacat ttatattatc 660 gggaccattc taaggtttcc ctctgctcag caaaggaaaa aggccttttc cacttgttct 720 tcccacatga ttgttgtttc cattacttat ggtagctgta tcttcattta tgtcaaacct 780 tcagccaagg atgaggtagc tattaataaa gggatttcac tccttattac ttctatctca 840 ccaatgttga acccctttat ttacacactg agaaacaagc aagtgaagaa agcttttcat 900 gattcaatta aaaaaatcgc attcctatca aagatgtaa 939

<210> 112

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069269_0225_SL.TXT <211> 312 <212> PRT <213> Canis familiaris <400> 112

Met Arg Asn Gln Thr Ala Leu Thr Thr Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Glu Asp Pro Gln Leu Lys Ile Leu Leu Phe Met Phe Leu Phe Leu Ser 20 25 30 Tyr Met Leu Asn Val Ser Gly Asn Leu Thr Ile Ile Ile Leu Thr Leu 35 40 45 Ile Asp Ser His Leu Lys Thr Pro Met Tyr Leu Phe Leu Gln Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Phe Thr Thr Ala Cys Val Pro Arg Phe Leu 65 70 75 80 Tyr Ser Ile Ser Ser Gly Asp Lys Ser Ile Thr Tyr Asn Ala Cys Val 85 90 95 Ser Gln Leu Leu Phe Thr Asp Leu Phe Ala Val Thr Glu Phe Phe Leu 100 105 110 Leu Ala Thr Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Ser Arg Arg Val Cys Lys Asn Phe Ile Val 130 135 140 Phe Cys Trp Val Ala Ala Leu Ile Ile Ile Leu Pro Pro Ile Ser Leu 145 150 155 160 Gly Leu Gly Leu Glu Phe Cys Asp Ser Asn Ile Ile Asp His Phe Cys 165 170 175 Cys Asp Ala Ser Pro Ile Leu Lys Ile Ser Cys Ser Asp Thr Trp Leu 180 185 190

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Ile Glu Gln 195 Met Val Ile Val Cys Ala Val Leu Thr Phe Ile Ile Thr 200 205 Leu Met Cys Val Val Leu Ser Tyr Ile Tyr Ile Ile Gly Thr Ile Leu 210 215 220 Arg Phe Pro Ser Ala Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile 245 250 255 Tyr Val Lys Pro Ser Ala Lys Asp Glu Val Ala Ile Asn Lys Gly Ile 260 265 270 Ser Leu Leu Ile Thr Ser Ile Ser Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Lys Lys Ala Phe His Asp Ser Ile Lys 290 295 300 Lys Ile Ala Phe Leu Ser Lys Met 305 310

<210> 113 <211> 936 <212> DNA <213> Canis familiaris <400> 113

atgagaaacg gtacaataac aacattcatt ctgctgggac tgacagatga ccctgagctg 60 caagttctga tttttatctt tctatttctc acctacactt tgagtataac tggaaacctg 120 accatcatca tactcacttt tgtggatccc caccttaaaa cacccatgta ctttttctta 180 aaaaatttct ccttcttgga gatctcattc acatctgccg ttattcccag atatttgtat 240 agcatagcaa caggtgacaa tgttattacc tataatgctt gtgtcattca agtgtttttt 300 actgacctct gtggagtatc agagtttttt ctgctggctg ccatgtccta tgaccgctat 360 gttgccatct gcaaaccctt gcattatgtg atcataatga gtaacagtgt ctgcaggatt 420

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ctcaatatct gttgttgggt ggctggttta tgtataataa tcccaccact tagcctgggt 480 ttaaatctaa aattttgtga ctctaacata attgatcatt ttggctgtga tgcatttccc 540 ttagtgaaaa tctcatgttc agatacaagg ttcatggaat ggacagttat aatatgtgcc 600 atactgacct tgaatatgac tcttacctgt gtggttctgt catatgctta catcatcaag 660 acaattttta gattcccttc tgttcaacaa agaaaaaagg cctattcgac ctgttcttcc 720 cacatgattg tggtatccat cacctatggc acatgcattt tcatctatat gaatcctaca 780 gcaaaggaaa aagtgaccat taataaagtg gtttcactgc tcattttttc tatttcacct 840 acattgaacc catttattta taccttgaga aacaatcaag ttaagaaagc cttcgaggac 900 tcaatcaaaa gaattgcctt gctctcaact aagtaa 936

<210> 114 <211> 311 <212> PRT <213> Canis familiaris <400> 114

Met Arg Asn Gly Thr Ile Thr Thr Phe Ile Leu Leu Gly Leu Thr Asp 1 5 10 15 Asp Pro Glu Leu Gln Val Leu Ile Phe Ile Phe Leu Phe Leu Thr Tyr 20 25 30 Thr Leu Ser Ile Thr Gly Asn Leu Thr Ile Ile Ile Leu Thr Phe Val 35 40 45 Asp Pro His Leu Lys Thr Pro Met Tyr Phe Phe Leu Lys Asn Phe Ser 50 55 60 Phe Leu Glu Ile Ser Phe Thr Ser Ala Val Ile Pro Arg Tyr Leu Tyr 65 70 75 80 Ser Ile Ala Thr Gly Asp Asn Val Ile Thr Tyr Asn Ala Cys Val Ile 85 90 95 Gln Val Phe Phe Thr Asp Leu Cys Gly Val Ser Glu Phe Phe Leu Leu 100 105 110

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Ala Ala Met 115 Ser Tyr Asp Arg Tyr Val Ala Ile Cys 120 Lys 125 Pro Leu His Tyr Val Ile Ile Met Ser Asn Ser Val Cys Arg Ile Leu Asn Ile Cys 130 135 140 Cys Trp Val Ala Gly Leu Cys Ile Ile Ile Pro Pro Leu Ser Leu Gly 145 150 155 160 Leu Asn Leu Lys Phe Cys Asp Ser Asn Ile Ile Asp His Phe Gly Cys 165 170 175 Asp Ala Phe Pro Leu Val Lys Ile Ser Cys Ser Asp Thr Arg Phe Met 180 185 190 Glu Trp Thr Val Ile Ile Cys Ala Ile Leu Thr Leu Asn Met Thr Leu 195 200 205 Thr Cys Val Val Leu Ser Tyr Ala Tyr Ile Ile Lys Thr Ile Phe Arg 210 215 220 Phe Pro Ser Val Gln Gln Arg Lys Lys Ala Tyr Ser Thr Cys Ser Ser 225 230 235 240 His Met Ile Val Val Ser Ile Thr Tyr Gly Thr Cys Ile Phe Ile Tyr 245 250 255 Met Asn Pro Thr Ala Lys Glu Lys Val Thr Ile Asn Lys Val Val Ser 260 265 270 Leu Leu Ile Phe Ser Ile Ser Pro Thr Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Asn Gln Val Lys Lys Ala Phe Glu Asp Ser Ile Lys Arg 290 295 300 Ile Ala Leu Leu Ser Thr Lys

305 310

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069269_0225_SL.TXT <210> 115 <211> 942 <212> DNA <213> Canis familiaris <400> 115

aatctgttat ttttgcagct ttaaaaaaaa gaatattcca acataaataa ttgttctagc 60 tctgtgagtg aattcatcct tttggtcttc ccttctacct gggaaattca gattctcctt 120 ttctcaatct tctgtggaac ttatattctg acactgactg gaaatctgtg cattatctgt 180 gctgtgaggt gggaccatag cctacaaact ccaatgtaca tcctgctggc caatttctcc 240 ttcctggaga tctgctttat cacctccact gtccccaaaa tgctagccaa cttgctgtct 300 gagaccagaa ccatctgctt ctatggctgc ttcctccagt tctacttctt ctctgagggc 360 accgctgaga ccttcttctt gtctgccatg gcctttgaca ggtttcttgc tacctgcagg 420 cccctgcact accccactgt catgactgct cagcgctgca tcagaatagg agctgggtgc 480 tgggtgtgtg gtttcttata cttcctcttg cctatttacc tcatctctca gctcccattt 540 tgttgttcta ataagattga tcacttcctg tgtgacccag gacctcttat gaagctgtcc 600 tgtgtgccag ctcctgctac tgagatcatc tgtgccatct ataactcagt cctcactttc 660 tccaccttat tcttcattac cagcttctat accttggtga tcagagctgt gctcagggtc 720 ccctcagcat aaggtcggca taaggccttc tctacgtgtg gctcccatct ggctgtggtg 780 tccctgtttt atggctctat catggctgta tatgtaagcc ccacagcagg cactccagca 840 gggattctgt gttaactcca cttttcaacc ccttgatcta tagcctctga aataaggaag 900 atgaaggcag ctctgggaaa ataattcagg attgtcagat tt 942

<210> 116 <211> 29 <212> PRT <213> Canis familiaris <400> 116

Asn Leu Thr Ile Leu Asn Tyr Phe Pro Arg Ala Ala Phe Ile Phe Leu 1 5 10 15

Ile Ser Glu Ala Ile Asp Gln Gly Val Glu Lys Trp Ser Page 123

069269_0225_SL.TXT <210> 117 <211> 456 <212> DNA <213> Canis familiaris <400> 117

ggaagtcaag ctctcccctt cgcagatgac atgatcagcc cctactgtgg ttctctggaa 60 atggatcact tcttctgtta ggtccctgct ctgctgagtc tctcctgcgc tgacaccttg 120 ctctttgatg atctcatgta tgcttgctgt gtagtcatgc tgctgctgcc ccttgaggtc 180 cttgcggttt cctatgcctg agtcctcaca gctgtcatta ggttgccttc cacagatggt 240 aaacagaagg ctctgaccac ttgctcttcc cctgtggctg tgctgtacta tggagtagcc 300 atgtttagct acatacagag gacctccagt aggacaccag tgagtgactg agccacttcc 360 atcttctaca caatcctcac tccaatgctc aacccactca tttacagtct gaggaacagg 420 gaggtaacaa gtgccctcag gaaggtgctg gggaga 456

<210> 118 <211> 152 <212> PRT <213> Canis familiaris <400> 118

Ser Pro Gln His Leu Pro Glu Gly Thr Cys Tyr Leu Pro Val Pro Gln 1 5 10 15 Thr Val Asn Glu Trp Val Glu His Trp Ser Glu Asp Cys Val Glu Asp 20 25 30 Gly Ser Gly Ser Val Thr His Trp Cys Pro Thr Gly Gly Pro Leu Tyr 35 40 45 Val Ala Lys His Gly Tyr Ser Ile Val Gln His Ser His Arg Gly Arg 50 55 60 Ala Ser Gly Gln Ser Leu Leu Phe Thr Ile Cys Gly Arg Gln Pro Asn 65 70 75 80

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Asp Ser Cys Glu Asp Ser Gly Ile Gly Asn Arg Lys Asp Leu Lys Gly 85 90 95 Gln Gln Gln His Asp Tyr Thr Ala 100 Ser Ile His 105 Glu Ile Ile 110 Lys Glu Gln Gly Val Ser Ala Gly Glu Thr 115 120 Gln Gln Ser Arg Asp Leu 125 Thr Glu Glu Val Ile His Phe Gln Arg Thr 130 135 Cys Glu Gly Glu Ser Leu Thr Ser 145 150 <210> 119 <211> 303 <212> DNA <213> Canis familiaris Thr Val Gly Ala Asp His 140 Val Ile <400> 119 ggccttttca cccactcccc actgcacctc ctcctttttt ccatcatcat agtaatgttc 60 ctggtggccc tctctggcaa tgggctcatg atcctcctca taaatgttga ctcccgcctg 120 cacagcccca tgtacttctt cctcagctgg ctgtcactca tggaccttat gctcatctcc 180 accattgtgc cacggatggc caccaacttc ttcctgggcc atggatccat ctccttcaca 240 ggctgtgggc tccagatcct cttctttctc gcc <210> 120 <211> 101 <212> PRT <213> Canis familiaris tctctcctgg gggatgaatg cttcctgctg 300 303 <400> 120 Gly Leu Phe Thr His Ser Pro Leu 1 5 His Leu Leu 10 Leu Phe Ser Ile Ile 15 Ile Val Met Phe Leu Val Ala Leu Ser Gly Asn Gly Leu Met Ile Leu

20 25 30

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Leu Ile Asn 35 Val Asp Ser Arg Leu His Ser Pro Met Tyr Phe Phe Leu 40 45 Ser Trp Leu Ser Leu Met Asp Leu Met Leu Ile Ser Thr Ile Val Pro 50 55 60 Arg Met Ala Thr Asn Phe Phe Leu Gly His Gly Ser Ile Ser Phe Thr 65 70 75 80 Gly Cys Gly Leu Gln Ile Leu Phe Phe Leu Ser Leu Leu Gly Asp Glu 85 90 95 Cys Phe Leu Leu Ala

100 <210> 121 <211> 948 <212> DNA <213> Canis familiaris <400> 121

atggagatat ggttgaaccg aacatctata gatggcttca tcctcttggg catcttttcc 60 catagccaga ctgatcttgt cctattctct gtggttatgg tggtcttcac agtggccctc 120 tgtgggaatg ttctcctcct cttcctcatc tacatagatc ctcggcttca cacacccatg 180 tatttcttcc tcagtcagct ctctctcatg gacctcatgt tggtctgtgc aaatgtgcca 240 aagatggcag tcaacttcct gtctggcagg aagtccatct cctttgtggg ttgtggcata 300 caaattggct tttttgtctc tcttgtggga tctgaggggc tcttgctggg actcatggct 360 tatgatcgct atgtggccat tagccaccca cttcactatc ctatcctcat gagtcagaag 420 gtctgtctca agtttgctgg gagttcctgg gcctttggga tactagatgg aattatccag 480 atggtggcag ccatgagctt accttactgt ggctcaagga ttgtggatca tttcttctgt 540 gaggtgccag ctttattaaa actggcctgt acagacacat ccctttttga cactctgctc 600 tttgcttgct gtgtctttat gctgcttctt cccttctcca ttattgtggc ctcctatgcc 660 catatcctga gggctgtgct ccacatgtgc tctgctcagg cccgtaaaaa ggccctggcc 720 acctgttcct cccacctgac agctgtctcc ctcttctatg gggcagccat gttcatctac 780

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069269_0225_SL.TXT ctgaggcctc ggcgctaccg ggcccctagt catgacaagg cggtctctat cttctacaca gtccttactc ctatgctcaa ccccctcatt tatagcttaa gaaaccaaga agtgatgggg gccctgagga aggggctgga tcattgcagg attggcagcc agcactga

840

900

948 <210> 122 <211> 315 <212> PRT <213> Canis familiaris <400> 122

Met Glu 1 Ile Trp Leu Asn Arg Thr Ser Ile Asp Gly Phe Ile Leu Leu 5 10 15 Gly Ile Phe Ser His Ser Gln Thr Asp Leu Val Leu Phe Ser Val Val 20 25 30 Met Val Val Phe Thr Val Ala Leu Cys Gly Asn Val Leu Leu Leu Phe 35 40 45 Leu Ile Tyr Ile Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Gln Leu Ser Leu Met Asp Leu Met Leu Val Cys Ala Asn Val Pro 65 70 75 80 Lys Met Ala Val Asn Phe Leu Ser Gly Arg Lys Ser Ile Ser Phe Val 85 90 95 Gly Cys Gly Ile Gln Ile Gly Phe Phe Val Ser Leu Val Gly Ser Glu 100 105 110 Gly Leu Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser 115 120 125 His Pro Leu His Tyr Pro Ile Leu Met Ser Gln Lys Val Cys Leu Lys 130 135 140 Phe Ala Gly Ser Ser Trp Ala Phe Gly Ile Leu Asp Gly Ile Ile Gln 145 150 155 160

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Met Val Ala Ala Met Ser Leu Pro Tyr Cys Gly Ser Arg Ile Val Asp 165 170 175 His Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ala Cys Thr Asp 180 185 190 Thr Ser Leu Phe Asp Thr Leu Leu Phe Ala Cys Cys Val Phe Met Leu 195 200 205 Leu Leu Pro Phe Ser Ile Ile Val Ala Ser Tyr Ala His Ile Leu Arg 210 215 220 Ala Val Leu His Met Cys Ser Ala Gln Ala Arg Lys Lys Ala Leu Ala 225 230 235 240 Thr Cys Ser Ser His Leu Thr Ala Val Ser Leu Phe Tyr Gly Ala Ala 245 250 255 Met Phe Ile Tyr Leu Arg Pro Arg Arg Tyr Arg Ala Pro Ser His Asp 260 265 270 Lys Ala Val Ser Ile Phe Tyr Thr Val Leu Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Gln Glu Val Met Gly Ala Leu Arg Lys 290 295 300 Gly Leu Asp His Cys Arg Ile Gly Ser Gln His 305 310 315

<210> 123 <211> 933 <212> DNA <213> Canis familiaris <400> 123 atggaaacag ctaatgacag cacaggtggg tatttcatcc tagtgggctt ctctgaacgg cctgagttag agctgatcct ctctttcttt gtcctgatgt tctacactgt aactcttgtg

120

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ggcaatgtgg ccatcgtcct gctctctatc ctggatactg gacttcacac acccatgtac 180 ttcttcctta gaaacctctc tgtgcttgac ctctgcttca ccaccagtat tgtgccccag 240 atgctggtga acatgtgggg aggcaacaag aagatcagtt atgctggctg catggtccag 300 tactgggtgg ccttggcact tggctccact gagtgtgtgc tccttgcagt gatggcggtt 360 gaccgctatg ttgcagtttg ctggcctctg cgctatgcct gtatcatgca cgccaggctg 420 tgccacctcc tggcagcagc ttcctggtcc tttggttttg ccaactcctt tttacagtcc 480 tcaatggcca tcgtgctgcc tcgatgtgga aaccggcgtg tggaccattt cttttgtgaa 540 ttgttgatca tcattaaact ctcctgtgtg gatactggcc caacagaatc taaaatgttt 600 attgcccggc taatcatcct aggcatgcct gtctccatca tcctgaccac ttacgtatgc 660 atcaccaggg cagtagtaaa aatgcgctca gcagagggaa ggaaaaaggc ctttgggacc 720 tgtgcctccc acctaatggt agtctcactc ttctatggga ccattatgtt tttgtatctg 780 cagcccaagg acaactactc ccaggaccag agcaaagcac tggcagtgct gtacatgatc 840 cttgcaccca cactcaaccc tctgatctac acgctgagga ataaggatgt gaagaaagca 900 gtcaggagga tgatagggaa ggagcaggtg tag 933

<210> 124 <211> 310 <212> PRT <213> Canis familiaris <400> 124

Met 1 Glu Thr Ala Asn Asp Ser Thr Gly Gly Tyr Phe Ile Leu Val Gly 5 10 15 Phe Ser Glu Arg Pro Glu Leu Glu Leu Ile Leu Ser Phe Phe Val Leu 20 25 30 Met Phe Tyr Thr Val Thr Leu Val Gly Asn Val Ala Ile Val Leu Leu 35 40 45 Ser Ile Leu Asp Thr Gly Leu His Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Val Leu Asp Leu Cys Phe Thr Thr Ser Ile Val Pro Gln

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Met Leu Val Asn Met Trp Gly Gly Asn Lys Lys Ile Ser Tyr Ala Gly 85 90 95 Cys Met Val Gln Tyr Trp Val Ala Leu Ala Leu Gly Ser Thr Glu Cys 100 105 110 Val Leu Leu Ala Val Met Ala Val Asp Arg Tyr Val Ala Val Cys Trp 115 120 125 Pro Leu Arg Tyr Ala Cys Ile Met His Ala Arg Leu Cys His Leu Leu 130 135 140 Ala Ala Ala Ser Trp Ser Phe Gly Phe Ala Asn Ser Phe Leu Gln Ser 145 150 155 160 Ser Met Ala Ile Val Leu Pro Arg Cys Gly Asn Arg Arg Val Asp His 165 170 175 Phe Phe Cys Glu Leu Leu Ile Ile Ile Lys Leu Ser Cys Val Asp Thr 180 185 190 Gly Pro Thr Glu Ser Lys Met Phe Ile Ala Arg Leu Ile Ile Leu Gly 195 200 205 Met Pro Val Ser Ile Ile Leu Thr Thr Tyr Val Cys Ile Thr Arg Ala 210 215 220 Val Val Lys Met Arg Ser Ala Glu Gly Arg Lys Lys Ala Phe Gly Thr 225 230 235 240 Cys Ala Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr Ile Met 245 250 255 Phe Leu Tyr Leu Gln Pro Lys Asp Asn Tyr Ser Gln Asp Gln Ser Lys 260 265 270 Ala Leu Ala Val Leu Tyr Met Ile Leu Ala Pro Thr Leu Asn Pro Leu

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275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Lys Ala Val Arg Arg Met 290 295 300 Ile Gly Lys Glu Gln Val 305 310

<210> 125 <211> 939 <212> DNA <213> Canis familiaris <400> 125

atggacagag acaaccagac tacagtcaca gaattccttc ttctgggact ctctgggcag 60 tcagagcaag aagacattct ctttgggcta ttcttgggga tgtacctggt caccatcatc 120 gggaactttc tcattgtctt ggccatcagc agtgacagtc atctccacac ccccatgtac 180 ttcttcttgg ctaacctctc ctgtgtcgac atctgctttt catcggtcac aacccccaag 240 atgctggtga atcacatcct gggaagcgag tctatctcgt acatggaatg catgatccag 300 atctacttct tcatcacttt caccaacatg gatgggttct tcttgagtgt gatggcctat 360 gatcgttatg tagccgtctg ttgcccgctc cactacacca tgatcatgaa gcccaaactc 420 tgtatgcttc tggtggtggc atcttgggtc attacaaacc tgcatgctct cctccacacc 480 cttcttatgg cccaactcgc atattgtttc aacaatactg tgcatcactt tttctgtgac 540 ccctatgcaa ttctaaagct gtcctgttct agtaccttta tcaatgacct gatggtattc 600 actgtgggtg gactggtatt tctgacaccg ttcacatgta tcatcatttc atatgcttat 660 atcctctcca atgtactgaa gttgccatct gcccatggaa taaggaaagc attctccaca 720 tgtgggtctc acctcactgt ggtctcccta ttctatgggg caattttggg ggtgtatatg 780 cgcccttcat cctcctactc agtccaagac acagtggcca ctgtcatctt cacagtggtg 840 actcccttgg tcaatccctt catctacagc ctgagaaatc atgacatgca gagagctttg 900 aggaaactaa tctcagtttc tagaattaga aaattttag 939

<210> 126 <211> 312

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069269_0225_SL.TXT <212> PRT <213> Canis familiaris <400> 126

Met Asp Arg Asp Asn Gln Thr Thr Val Thr Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Ser Gly Gln Ser Glu Gln Glu Asp Ile Leu Phe Gly Leu Phe Leu 20 25 30 Gly Met Tyr Leu Val Thr Ile Ile Gly Asn Phe Leu Ile Val Leu Ala 35 40 45 Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Cys Val Asp Ile Cys Phe Ser Ser Val Thr Thr Pro Lys 65 70 75 80 Met Leu Val Asn His Ile Leu Gly Ser Glu Ser Ile Ser Tyr Met Glu 85 90 95 Cys Met Ile Gln Ile Tyr Phe Phe Ile Thr Phe Thr Asn Met Asp Gly 100 105 110 Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Cys 115 120 125 Pro Leu His Tyr Thr Met Ile Met Lys Pro Lys Leu Cys Met Leu Leu 130 135 140 Val Val Ala Ser Trp Val Ile Thr Asn Leu His Ala Leu Leu His Thr 145 150 155 160 Leu Leu Met Ala Gln Leu Ala Tyr Cys Phe Asn Asn Thr Val His His 165 170 175 Phe Phe Cys Asp Pro Tyr Ala Ile Leu Lys Leu Ser Cys Ser Ser Thr 180 185 190

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Phe Ile Asn 195 Asp Leu Met Val 069269_0225_SL.TXT Phe Thr Val Gly Gly Leu 200 205 Val Phe Leu Thr Pro Phe Thr Cys Ile Ile Ile Ser Tyr Ala Tyr Ile Leu Ser Asn 210 215 220 Val Leu Lys Leu Pro Ser Ala His Gly Ile Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Ala Ile Leu 245 250 255 Gly Val Tyr Met Arg Pro Ser Ser Ser Tyr Ser Val Gln Asp Thr Val 260 265 270 Ala Thr Val Ile Phe Thr Val Val Thr Pro Leu Val Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn His Asp Met Gln Arg Ala Leu Arg Lys Leu Ile 290 295 300 Ser Val Ser Arg Ile Arg Lys Phe

305 310 <210> 127 <211> 942 <212> DNA <213> Canis familiaris <400> 127

atgtccaggg ggaaggagaa tgtgacagga gtcaccgagt tcctcctact tggcatcacc 60 agtgaccccg agcagcggca agtcctcttc tggctcttcc tgtgtatgta cctggtcact 120 gtggctggga acacactcat catcctggtc atcggctccc atccccgcct gcacaccccc 180 atgtacttct tccttatcaa tctctccttt gttgacatct gcttcactac caacctgatc 240 cccaagctgc tggtcaacca cgtagcagga acatggacta tctcttaccc ccactgcctg 300 acccagatgt acttcctcat ctcctttgcc aacctggaca cctttctgct agcggccatg 360 gcactggacc gttatgtggc catctgcaaa cccctgctat accacaccat catcactcct 420

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cagctctgta ggggactaac cacactcatg tggacatgct ctggcctcat ctccctggtt 480 cacacactcc tcatgaacgg actgacattc tgctcctcag cccgggagat cttgcacttc 540 tactgtgatg cctacctgct gatgaagatt gcctgctcag acacgcgtgt caatcaacac 600 atgttcctgg gtgccgtggt cctatttgtg gccccctgtg cgctcattgt agtttcctac 660 atccgcatag ctacagccgt cctccggatc ccttctgccc tgggaaggcg caaggcattt 720 tccacatgca gctcccatct atctgtggtc accttgttct atggaactgt cctgggggta 780 tacatacgac cacctaagtc cttctcagtc caggacacag tggcaactgt catgtataca 840 gtggtgacgc ccatgctaaa tcccttcatc tacagcctga ggaaccagga catgaaggag 900 gctgtaggaa gactcttcag caagggctcc aaatcctctt ag 942

<210> 128 <211> 313 <212> PRT <213> Canis familiaris <400> 128

Met Ser Arg Gly Lys Glu Asn Val Thr Gly Val Thr Glu Phe Leu Leu 1 5 10 15 Leu Gly Ile Thr Ser Asp Pro Glu Gln Arg Gln Val Leu Phe Trp Leu 20 25 30 Phe Leu Cys Met Tyr Leu Val Thr Val Ala Gly Asn Thr Leu Ile Ile 35 40 45 Leu Val Ile Gly Ser His Pro Arg Leu His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ile Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Thr Asn Leu Ile 65 70 75 80 Pro Lys Leu Leu Val Asn His Val Ala Gly Thr Trp Thr Ile Ser Tyr 85 90 95 Pro His Cys Leu Thr Gln Met Tyr Phe Leu Ile Ser Phe Ala Asn Leu 100 105 110

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Asp Thr Phe 115 Leu Leu Ala Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 120 125 Cys Lys Pro Leu Leu Tyr His Thr Ile Ile Thr Pro Gln Leu Cys Arg 130 135 140 Gly Leu Thr Thr Leu Met Trp Thr Cys Ser Gly Leu Ile Ser Leu Val 145 150 155 160 His Thr Leu Leu Met Asn Gly Leu Thr Phe Cys Ser Ser Ala Arg Glu 165 170 175 Ile Leu His Phe Tyr Cys Asp Ala Tyr Leu Leu Met Lys Ile Ala Cys 180 185 190 Ser Asp Thr Arg Val Asn Gln His Met Phe Leu Gly Ala Val Val Leu 195 200 205 Phe Val Ala Pro Cys Ala Leu Ile Val Val Ser Tyr Ile Arg Ile Ala 210 215 220 Thr Ala Val Leu Arg Ile Pro Ser Ala Leu Gly Arg Arg Lys Ala Phe 225 230 235 240 Ser Thr Cys Ser Ser His Leu Ser Val Val Thr Leu Phe Tyr Gly Thr 245 250 255 Val Leu Gly Val Tyr Ile Arg Pro Pro Lys Ser Phe Ser Val Gln Asp 260 265 270 Thr Val Ala Thr Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285 Phe Ile Tyr Ser Leu Arg Asn Gln Asp Met Lys Glu Ala Val Gly Arg 290 295 300 Leu Phe Ser Lys Gly Ser Lys Ser Ser 305 310

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069269_0225_SL.TXT <210> 129 <211> 981 <212> DNA <213> Canis familiaris <400> 129

atggcaaacc agacggctgt gaccgaatac atcttgctgg ggcttcagga gcaccataag 60 ctcgagatgg tcctgtttgt gctctgcctg ggcatctact ctgtgaatgt gctggggaac 120 tccctcctca tagtgctgaa catgttggac ccccgtctgc acagccccat gtacttcttc 180 ctcagcaacc tctccctgat ggacatctgt ggcacatcct cctttgtgcc tctcatggtg 240 gtcaacttcc tgaaaaccca gaggaccatc tccttccctg gctgtgccct gcagatgtac 300 ctgaccctgg ctctgggcac cacggagtgc ctgcttctgg cagtgatggc atacgaccgt 360 tatgtggcca tctgccagcc acttaggtac ccagagatca tgcgtaggca gacgtgtgtg 420 cagatggtgg tgctgagctg ggggatgggc tttgccaatt cactgctgca gtcctttctt 480 acctggaatg tctccttctg tggccacaat atcatcaacc acttcttctg cgagatcttg 540 gcagtgctga aactggcctg cggggacatc tctctcaatg cactgctaat aatggtggcc 600 acagttatcc tgacactggc cccacttctg ctcatcttcc tgtcctacat tttcatcctc 660 gctaccatcc ttagggtgcc ctcagctgca ggccggtgca aagccttctc cacctgctct 720 gcccacatca tagtggtggt agttttctat gggaccatct ccttcatgta cttcaagccc 780 aaggccaagg accctgacct ggataagatt attgcattgt tctatggggt tgtgacaccc 840 tcactgaacc ccatcatcta cagcctgagg aacgcagaag tgaaagctgc tgctatagcc 900 ctgctgtggg gagacctgct ctccaggaag atgtcccatc ttccctgttg ctcttcaact 960 ctatcatgca tggcaggcta ^g 981

<210> 130 <211> 326 <212> PRT <213> Canis familiaris <400> 130

Met Ala Asn Gln Thr Ala Val Thr Glu Tyr Ile Leu Leu Gly Leu Gln 1 5 10 15

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Glu His His Lys 20 Leu Glu Met Val Leu 25 Phe Val Leu Cys Leu 30 Gly Ile Tyr Ser Val Asn Val Leu Gly Asn Ser Leu Leu Ile Val Leu Asn Met 35 40 45 Leu Asp Pro Arg Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Met Asp Ile Cys Gly Thr Ser Ser Phe Val Pro Leu Met Val 65 70 75 80 Val Asn Phe Leu Lys Thr Gln Arg Thr Ile Ser Phe Pro Gly Cys Ala 85 90 95 Leu Gln Met Tyr Leu Thr Leu Ala Leu Gly Thr Thr Glu Cys Leu Leu 100 105 110 Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln Pro Leu 115 120 125 Arg Tyr Pro Glu Ile Met Arg Arg Gln Thr Cys Val Gln Met Val Val 130 135 140 Leu Ser Trp Gly Met Gly Phe Ala Asn Ser Leu Leu Gln Ser Phe Leu 145 150 155 160 Thr Trp Asn Val Ser Phe Cys Gly His Asn Ile Ile Asn His Phe Phe 165 170 175 Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Gly Asp Ile Ser Leu 180 185 190 Asn Ala Leu Leu Ile Met Val Ala Thr Val Ile Leu Thr Leu Ala Pro 195 200 205 Leu Leu Leu Ile Phe Leu Ser Tyr Ile Phe Ile Leu Ala Thr Ile Leu 210 215 220

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Arg Val Pro Ser Ala Ala Gly Arg Cys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ala His Ile Ile Val Val Val Val Phe Tyr Gly Thr Ile Ser Phe Met 245 250 255 Tyr Phe Lys Pro Lys Ala Lys Asp Pro Asp Leu Asp Lys Ile Ile Ala 260 265 270 Leu Phe Tyr Gly Val Val Thr Pro Ser Leu Asn Pro Ile Ile Tyr Ser 275 280 285 Leu Arg Asn Ala Glu Val Lys Ala Ala Ala Ile Ala Leu Leu Trp Gly 290 295 300 Asp Leu Leu Ser Arg Lys Met Ser His Leu Pro Cys Cys Ser Ser Thr 305 310 315 320 Leu Ser Cys Met Ala Gly 325

<210> 131 <211> 960 <212> DNA <213> Canis familiaris <400> 131 atgtctcctg agcactgcaa tatggagttg gtcaatagga cagagatctt tgagttcttt 60 ctgaaaggat tttctggcta cccagccctg gagcacctgc tcttccctct gtgctcagcc 120 atgtacctgg tgaccctgct ggggaacaca gccatcgtgg cagtgagtgt cctcgatgtc 180 cacctacaca cgcccatgta cttcttcctg ggcaacctct ccatcctgga catctgctac 240 acatctacct ttgtgcctct gatgctggtc cacctcctgt cagcccagaa gaccatctct 300 tttgttggct gtgcaatcca gatgtgtctg agcctagcca caggctccac agagtgtcta 360 cttcttgcca tcatggccta cgatcgctac ctggccattt gccggccact caggtatccc 420 gtgctcatga gccaccggct ctgcttgttg ctggcaggag ccgcctgggg actctgtctt 480 gtcaagtcaa tgactgagac tgtcattgcc atgaggttgc ctttctgtgg ccaccgcatg 540

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gttagtcact tcacctgtga gatcctggca gtgctgaagc tggcatgcag tgacacatca 600 gtcagtgaag tcttcctgct ggtgggtgcc attctgctgc tgcctatacc cctggcattc 660 atctgcctgt cctacacact tatcctggcc accatcctga gagtgccctc agcagctggg 720 cgtcgcaaag ccttctccac ctgctcagca cacctggctg tggtgatgct gttctacggc 780 accgtcatat tcatgtacat gaaacccaag agcaaggagg cccacatctc tgatgaggtc 840 ttcacagtcc tctatgctgt tgtcacacct atgctgaacc ctgtcatcta cagcttgagg 900 aacaaggagg taaaggaggc tgccaggaaa gtatggtgta ggagttggac atccaagtga 960

<210> 132 <211> 319 <212> PRT <213> Canis familiaris <400> 132

Met Ser Pro Glu His Cys Asn Met Glu Leu Val Asn Arg Thr Glu Ile 1 5 10 15 Phe Glu Phe Phe Leu Lys Gly Phe Ser Gly Tyr Pro Ala Leu Glu His 20 25 30 Leu Leu Phe Pro Leu Cys Ser Ala Met Tyr Leu Val Thr Leu Leu Gly 35 40 45 Asn Thr Ala Ile Val Ala Val Ser Val Leu Asp Val His Leu His Thr 50 55 60 Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser Ile Leu Asp Ile Cys Tyr 65 70 75 80 Thr Ser Thr Phe Val Pro Leu Met Leu Val His Leu Leu Ser Ala Gln 85 90 95 Lys Thr Ile Ser Phe Val Gly Cys Ala Ile Gln Met Cys Leu Ser Leu 100 105 110 Ala Thr Gly Ser Thr Glu Cys Leu Leu Leu Ala Ile Met Ala Tyr Asp 115 120 125

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Arg Tyr 130 Leu Ala Ile Cys Arg Pro Leu Arg Tyr Pro Val Leu Met Ser 135 140 His Arg Leu Cys Leu Leu Leu Ala Gly Ala Ala Trp Gly Leu Cys Leu 145 150 155 160 Val Lys Ser Met Thr Glu Thr Val Ile Ala Met Arg Leu Pro Phe Cys 165 170 175 Gly His Arg Met Val Ser His Phe Thr Cys Glu Ile Leu Ala Val Leu 180 185 190 Lys Leu Ala Cys Ser Asp Thr Ser Val Ser Glu Val Phe Leu Leu Val 195 200 205 Gly Ala Ile Leu Leu Leu Pro Ile Pro Leu Ala Phe Ile Cys Leu Ser 210 215 220 Tyr Thr Leu Ile Leu Ala Thr Ile Leu Arg Val Pro Ser Ala Ala Gly 225 230 235 240 Arg Arg Lys Ala Phe Ser Thr Cys Ser Ala His Leu Ala Val Val Met 245 250 255 Leu Phe Tyr Gly Thr Val Ile Phe Met Tyr Met Lys Pro Lys Ser Lys 260 265 270 Glu Ala His Ile Ser Asp Glu Val Phe Thr Val Leu Tyr Ala Val Val 275 280 285 Thr Pro Met Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Glu Val 290 295 300 Lys Glu Ala Ala Arg Lys Val Trp Cys Arg Ser Trp Thr Ser Lys

305 310 315 <210> 133 <211> 960 <212> DNA

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atggaaaaag ccaactggtc ctcccctgtg gcggggttca ttatcctggg actctcagac 60 cacccagggt tggagaaaat gttttttgtg ctcatcctcc tgatgtacct ggtgatcctg 120 ctgggcaacg gggtcctcat cctggtgacc atccttgact cccgcctgca cacacccatg 180 tacttcttcc tggggaacct ctccttcctg gacatctgct acacaacctc ctcagtccct 240 ctagtcctgg atggcttcct gacccccagg aaaatcatct ccttctcagc ctgtgctgtg 300 cagatgttct tctcatttgc tatggcaggt acagagtgtg tgcttctggg catgatggca 360 tttgatcgct atgtggccat ctgtaacccg ctgaggtacc ctgtggtcat gagcaaggct 420 gcctatgtgc ccatggctgt cagctcctgg gctattggtg gtactgcttc tgtggtacac 480 acatccttga caattcagtt gcctttctgt ggaaacaatg tcatcaatca ccttgcctgt 540 gagatcctgg ctgtcctgag attggcctgt gttgacatct ccatcaatgt catcagcatg 600 cgggtggcca atgtgatctt gctgggggtc ccagttctgt tcatctctat ctcttatgtg 660 ttcatcattg ctaccatcct gaggatcccc tcagctgagg ggaggagaaa ggctttctcc 720 acctgctctg cccacttcac tgtggtggtc atcttctacg ggaccttatt tttcatgtat 780 agaaagccca aatctaagga ttcgctggaa gacaataaag aggacctttc agacaagctc 840 attcccctct tttatggagt ggtgaccccc atgctcaacc ccatcatcta tagcctcagg 900 aacaaggacg tgaagtctgc tgtgtggaac ctgatgtcac agaaatgctt caccaggtga 960

<210> 134 <211> 319 <212> PRT <213> Canis familiaris <400> 134

Met Glu Lys Ala Asn Trp Ser Ser Pro Val Ala Gly Phe Ile Ile Leu 1 5 10 15 Gly Leu Ser Asp His Pro Gly Leu Glu Lys Met Phe Phe Val Leu Ile 20 25 30 Leu Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu

35 40 45

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Val Thr 50 Ile Leu Asp Ser Arg Leu 55 His Thr Pro Met Tyr Phe Phe 60 Leu Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro 65 70 75 80 Leu Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Ile Ile Ser Phe Ser 85 90 95 Ala Cys Ala Val Gln Met Phe Phe Ser Phe Ala Met Ala Gly Thr Glu 100 105 110 Cys Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro 130 135 140 Met Ala Val Ser Ser Trp Ala Ile Gly Gly Thr Ala Ser Val Val His 145 150 155 160 Thr Ser Leu Thr Ile Gln Leu Pro Phe Cys Gly Asn Asn Val Ile Asn 165 170 175 His Leu Ala Cys Glu Ile Leu Ala Val Leu Arg Leu Ala Cys Val Asp 180 185 190 Ile Ser Ile Asn Val Ile Ser Met Arg Val Ala Asn Val Ile Leu Leu 195 200 205 Gly Val Pro Val Leu Phe Ile Ser Ile Ser Tyr Val Phe Ile Ile Ala 210 215 220 Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ala His Phe Thr Val Val Val Ile Phe Tyr Gly Thr Leu 245 250 255

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Phe Phe Met Tyr Arg Lys Pro Lys Ser 265 Lys Asp Ser Leu Glu 270 Asp Asn 260 Lys Glu Asp Leu Ser Asp Lys Leu Ile Pro Leu Phe Tyr Gly Val Val 275 280 285 Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val 290 295 300 Lys Ser Ala Val Trp Asn Leu Met Ser Gln Lys Cys Phe Thr Arg 305 310 315

<210> 135 <211> 960 <212> DNA <213> Canis familiaris <400> 135

atggacaggt tcaattggac ttctcctgtg atggggttca tcctcctggg cctctcagcc 60 cacccgaagc tggagaaaat gttctttgtg ctcatcctct tgatgtacct ggtgatcctg 120 ctgggcaacg gggtcctcat cctggtgacc atccttgact cccgcctgca cacacccatg 180 tacttcttcc tggggaacct ctccttcctg gacatctgct acacaacctc ctcagtcccc 240 cttattcttg acagcttcct gacccccagc aaaaccatac ccttctcagc ctgtgctgtg 300 cagatgtttc tctcctttgc catgggagcc acagagtgtg tgctactggg catgatggca 360 tttgatcgct atgtggccat ctgtaaccca cttaggtacc ctgtggtcat gagcaaggct 420 gcctatgtgc ccatggctgc cagctcctgg gcagctggaa gcatgactgc cacggtgcaa 480 acatccttag cgatgcgact gcctttctgt ggggacaaca tcatcaacca cttcacctgt 540 gagatcctgg cagtcctaaa gttggcctgt gctgatattt ccatcaatgt gatcagtatg 600 gcagtggcta atgtgatctt ccttggcatt ccagttctat ttatttctgt ctcttatgtg 660 ttcatcattg ctaccatcct gaggatcccc tcagctgagg ggaggaaaaa ggccttctcc 720 acctgctctg cccacctcac tgtagtggtc atcttctatg gaacaatcct ctttatgtat 780 gggaagccca aatccaagga tcctcagggg gcagacaagc aggacatttc tgacaagctc 840

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960

069269_0225_SL.TXT acctccctct tttatggggt agtgaccccc atgctcaacc ccatcatcta cagcctgagg aacaaggacg tgaaggctgc tgtgaggaat ctggtacttc acaaacactt tatccagtga <210> 136 <211> 319 <212> PRT <213> Canis familiaris <400> 136

Met Asp Arg Phe Asn Trp Thr Ser Pro Val Met Gly Phe Ile Leu Leu 1 5 10 15 Gly Leu Ser Ala His Pro Lys Leu Glu Lys Met Phe Phe Val Leu Ile 20 25 30 Leu Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu 35 40 45 Val Thr Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro 65 70 75 80 Leu Ile Leu Asp Ser Phe Leu Thr Pro Ser Lys Thr Ile Pro Phe Ser 85 90 95 Ala Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu 100 105 110 Cys Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro 130 135 140 Met Ala Ala Ser Ser Trp Ala Ala Gly Ser Met Thr Ala Thr Val Gln 145 150 155 160 Thr Ser Leu Ala Met Arg Leu Pro Phe Cys Gly Asp Asn Ile Ile Asn

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165

His Phe Thr Cys 180 Glu Ile Leu Ala Ile Ser Ile 195 Asn Val Ile Ser Met 200 Gly Ile 210 Pro Val Leu Phe Ile 215 Ser Thr 225 Ile Leu Arg Ile Pro 230 Ser Ala Thr Cys Ser Ala His 245 Leu Thr Val Leu Phe Met Tyr 260 Gly Lys Pro Lys Lys Gln Asp 275 Ile Ser Asp Lys Leu 280 Thr Pro 290 Met Leu Asn Pro Ile 295 Ile Lys 305 Ala Ala Val Arg Asn 310 Leu Val

170 Lys 175 Asp Val 185 Leu Leu Ala Cys 190 Ala Ala Val Ala Asn Val 205 Ile Phe Leu Val Ser Tyr Val 220 Phe Ile Ile Ala Glu Gly Arg 235 Lys Lys Ala Phe Ser 240 Val Val 250 Ile Phe Tyr Gly Thr 255 Ile Ser 265 Lys Asp Pro Gln Gly 270 Ala Asp Thr Ser Leu Phe Tyr 285 Gly Val Val Tyr Ser Leu Arg 300 Asn Lys Asp Val Leu His Lys 315 His Phe Ile Gln

<210> 137 <211> 960 <212> DNA <213> Canis familiaris <400> 137 atggaaagtt ccaaccagac tgtctctgtg cacccgaagc tggagaaaat gttctttgtg ctgggcaacg gggtcctcat cctggtgact tacttcttct tggggaacct ctccttcctg acagagttta ttctactggg cctctcagcc ctcatcctct tgatgtacct ggtgatcctg gtgtctgtct cccacctgca cacacccatg gacatctgct acacaacctc ttcagttccc Page 145

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180

240

069269_0225_SL.TXT

ctcattcttg acagcttcct gacccccagg aaaaccatac ccttctcagc ctgtgccatg 300 cagatgtttc tctcctttgc catgggagcc acagagtgtg tgcttctggg catgatggca 360 tttgatcgct atgtggccat ctgtaacccg ctgaggtacc ctgtggtcat gagcaaggct 420 gcctatgtgc ccatggctgc cagctcctgg gcagctggaa gtgctgcctc tatggttcaa 480 acatcccttg caatgaaact tcccttctgt gggaacaata tcattaacca ctttacctgt 540 gagatcctgg ctattctaaa gttagcttgt gctgacatct ccatcaatgt gatcagtatg 600 ggggtgacaa atgtgatttt cctgggggtc ccagttctgt tcatctttgt ctcctatatc 660 ttcatcctca ccaccatcct aaggatcccc tcagctgagg gaagaaaaaa ggccttctcc 720 acctgctctg cccaccttgc agtcgtggtc atcttctatg ggactattct cttcatgtac 780 gggaagccca aatccaagga ccccctgggg gcagacaagc aggatgtttc agacaagctt 840 acctccctct tctatggggt ggtgaccccc atgctcaacc ccatcatcta cagcctgagg 900 aacaaggacg tgaaggctgc tgtgaggaac ctggtggctc aaaaatgctt tacccagtga 960 <210> 138 <211> 319 <212> PRT <213> Canis familiaris <400> 138 Met Glu Ser 1 Ser Asn Gln Thr Val 5 Ser Val Thr 10 Glu Phe Ile Leu Leu 15 Gly Leu Ser Ala His Pro Lys Leu 20 Glu Lys Met 25 Phe Phe Val 30 Leu Ile Leu Leu Met 35 Tyr Leu Val Ile Leu 40 Leu Gly Asn Gly Val Leu 45 Ile Leu Val Thr Val 50 Ser Val Ser His Leu 55 His Thr Pro Met Tyr Phe 60 Phe Leu Gly Asn Leu 65 Ser Phe Leu Asp Ile 70 Cys Tyr Thr 75 Thr Ser Ser Val Pro 80

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Leu Ile Leu Asp Ser 85 Phe Leu Thr Pro Arg Lys Thr Ile Pro Phe Ser 90 95 Ala Cys Ala Met Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu 100 105 110 Cys Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro 130 135 140 Met Ala Ala Ser Ser Trp Ala Ala Gly Ser Ala Ala Ser Met Val Gln 145 150 155 160 Thr Ser Leu Ala Met Lys Leu Pro Phe Cys Gly Asn Asn Ile Ile Asn 165 170 175 His Phe Thr Cys Glu Ile Leu Ala Ile Leu Lys Leu Ala Cys Ala Asp 180 185 190 Ile Ser Ile Asn Val Ile Ser Met Gly Val Thr Asn Val Ile Phe Leu 195 200 205 Gly Val Pro Val Leu Phe Ile Phe Val Ser Tyr Ile Phe Ile Leu Thr 210 215 220 Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ala His Leu Ala Val Val Val Ile Phe Tyr Gly Thr Ile 245 250 255 Leu Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp 260 265 270 Lys Gln Asp Val Ser Asp Lys Leu Thr Ser Leu Phe Tyr Gly Val Val 275 280 285

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Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val 290 295 300

Lys Ala Ala Val Arg Asn Leu Val Ala Gln Lys Cys Phe Thr Gln 305 310 315 <210> 139 <211> 954 <212> DNA <213> Canis familiaris <400> 139

atgaaaatgg ccaaccaatc tgttctggca ggatttgtct tgctggggct ctcagatcaa 60 ccaaagcttg agagaacatt ctttgtgctc atcctgtcga tgtacctggt gatcctactg 120 ggaaacgggg tcctcatcct ggtgaccatc catgactccc gcctgcacac acccatgtac 180 ttcttcctgg ggaacctttc cttcctggac atctgctaca caacctcctc aatccctcta 240 gtcctggatg gcttcctgac ccccaggaaa accatctcct tctcaggctg tgctgtgcag 300 atgtttctct cctttgccat gggagccaca gagtgtgtgc ttctgggcat gatggcattt 360 gatcgctatg tggccatctg taacccactt aggtaccctg tggtcatgag caaggctgcc 420 tatgtgccca tggctgccag ctcctgggtg gctggtggca tcaactcctt ggtgcagatc 480 tctcttgcag tacagttacc cttctgtggg gacaacatca tcaaccactt tacctgtgag 540 atcttggctg tcctaaagtt ggcctgtgct gacatctcca tcaatgtaat cagtatgggg 600 gtggccaatg tgatcttcct gggcgtccca gttctgttca tctctatctc ctacatcttc 660 atcctcacca ccatcctgaa gatcccttca gctgaaggga ggagaaaggc cttctccacc 720 tgctctgccc atctcactgt agtggtcatc ttctatggaa ctattctttt catgtatgca 780 aagcccaaat ctaaggaccc cctgggagca gacaagcagg atgtttcaga caagctcatc 840 tctctcttct atggagtgct gactcccatg ctcaacccaa tcatctacag cctaagaaac 900 aaggatgtga aggtcgctgt gaagaccctg gtgaggcaga aacgctttgc atag 954

<210> 140 <211> 317 <212> PRT <213> Canis familiaris

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<400> 140 Met 1 Lys Met Ala Asn Gln Ser Val Leu Ala Gly Phe Val Leu Leu Gly 5 10 15 Leu Ser Asp Gln Pro Lys Leu Glu Arg Thr Phe Phe Val Leu Ile Leu 20 25 30 Ser Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu Val 35 40 45 Thr Ile His Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Ile Pro Leu 65 70 75 80 Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 100 105 110 Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro Met 130 135 140 Ala Ala Ser Ser Trp Val Ala Gly Gly Ile Asn Ser Leu Val Gln Ile 145 150 155 160 Ser Leu Ala Val Gln Leu Pro Phe Cys Gly Asp Asn Ile Ile Asn His 165 170 175 Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Val Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly 195 200 205

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Val Pro Val Leu Phe Ile Ser Ile Ser Tyr Ile Phe Ile Leu Thr Thr 210 215 220 Ile Leu Lys Ile Pro Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Val Ile Phe Tyr Gly Thr Ile Leu 245 250 255 Phe Met Tyr Ala Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys 260 265 270 Gln Asp Val Ser Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Leu Thr 275 280 285 Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Val Ala Val Lys Thr Leu Val Arg Gln Lys Arg Phe Ala 305 310 315

<210> 141 <211> 957 <212> DNA <213> Canis familiaris <400> 141 atggaaggac ccaaccaatc tgctgtgaca gagttcgttt tgcttggcct ctctgcccat 60 ccaaaactag agaaaacatt ctttgtgctc atcctgtcga tgtacctggt gatcctactg 120 ggaaacgggg tcctcatcct ggtgaccatc catgactccc gcctgcacac acccatgtac 180 ttcttcctgg ggaacctctc cttcctggac atctgctaca caacctcctc agtccctcta 240 gtcctggatg gcttcctgac ccccaggaaa accatctcct tctcaggctg tgccgtgcag 300 atgtttctct cctttgccat gggagccaca gagtgtgtgc ttctgggcat gatggcattt 360 gatcgctatg tggccatctg taacccactt aggtaccctg tggtcatgag caaggctgcc 420 tatgtgccca tggctgccag ctcctgggtg gctggtggca tcaactcctt agtgcagatc 480 tctcttgcag tacagttacc tttctgtggg gacaatgtca tcaaccactt catctgtgag 540

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atcctggctg tcctaaagtt ggcctgtgct gacatctcca tcaatgtgat cagtatgggg 600 gtggccaatg tgatcttcct gggcgtccca gttctgttca tctctatctc ttatgtgttc 660 atcattgcta ccatcctgcg gatcccctca gcagagggga ggagaaaggc cttctccacc 720 tgctctgccc acctcactgt agtggtcatc ttctatggga ctattctttt catgtatgca 780 aaacccaaat ctaaggatcc cctgggagca gacaagcagg atgtttcaga caagctcatc 840 tccctcttct atggcctcct gactcccatg ctcaacccca tcatctacag tctgaggaac 900 aaggatgtta agaccgctgt gaggtacata gtggctcaga agcacttcac tcagtga 957

<210> 142 <211> 318 <212> PRT <213> Canis familiaris <400> 142

Met Glu Gly Pro Asn Gln Ser Ala Val Thr Glu Phe Val Leu Leu Gly 1 5 10 15 Leu Ser Ala His Pro Lys Leu Glu Lys Thr Phe Phe Val Leu Ile Leu 20 25 30 Ser Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu Val 35 40 45 Thr Ile His Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro Leu 65 70 75 80 Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 100 105 110 Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn

115 120 125

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Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro Met 130 135 140 Ala Ala Ser Ser Trp Val Ala Gly Gly Ile Asn Ser Leu Val Gln Ile 145 150 155 160 Ser Leu Ala Val Gln Leu Pro Phe Cys Gly Asp Asn Val Ile Asn His 165 170 175 Phe Ile Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Val Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly 195 200 205 Val Pro Val Leu Phe Ile Ser Ile Ser Tyr Val Phe Ile Ile Ala Thr 210 215 220 Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Val Ile Phe Tyr Gly Thr Ile Leu 245 250 255 Phe Met Tyr Ala Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys 260 265 270 Gln Asp Val Ser Asp Lys Leu Ile Ser Leu Phe Tyr Gly Leu Leu Thr 275 280 285 Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Thr Ala Val Arg Tyr Ile Val Ala Gln Lys His Phe Thr Gln 305 310 315

<210> 143 <211> 945

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069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 143

atggacaggt ccaatcagac ctctcctgtg atggggttta ttctcctggg cctctcagcc 60 cacccgaaac tggagaaaac cttctttgtg ctcattctcg tgatgtacct tgtaatcctg 120 ttgggcaacg gggtcctcat cctggtgacc atccttgatt cccacctgca cacacccatg 180 tacttcttcc tggggaacct ctccttcctg gacatctgct acacaacctc ttcagtcccc 240 cttattcttg acagcttcct gacccccagg aaaaccatac ccttctcagc ctgtgtcatg 300 cagatgtttc tctcctttgc catgggagcc acagagtgtg tgcttctggg catgatggca 360 tttgatcgct atgtggctat ctgtaacccg ctgaggtacc ctgtggtcat gagcaaggct 420 gcctatgtgc ccatggctgc cagctcctgg gcagctggta tcaccaactc tgtagtccag 480 acatcccagg ctatgaggct tcccttctgt ggggacaatg tcatcaatca cttcacctgt 540 gagatcctgg ctgtgctgaa gttggcctgt gctgacattt ctatcaatgt gattagcatg 600 gttgtggcta atgtgatctt cctgggggtc ccagttgtgt tcatttttgt ctcctatgtg 660 ttcatcattg ctaccatcct gaggatcccc tcagctgagg ggaggaaaaa ggccttctcc 720 acctgctctg cccacctcac cgtagtggtt gtcttctatg ggaccatcct cttcatgtat 780 gggaagccca aatccaagga cccccagggg gcagacaagc aggacatttc agacaagctc 840 acctccctct tttatggggt ggtgaccccc atgctcaacc ccatcatcta cagcctgagg 900 aacaaggacg tgaaggctgc tatgaagaac ctggtatgtc aataa 945

<210> 144 <211> 314 <212> PRT <213> Canis familiaris <400> 144

Met Asp Arg Ser Asn Gln Thr Ser Pro Val Met Gly Phe Ile Leu Leu 1 5 10 15 Gly Leu Ser Ala His Pro Lys Leu Glu Lys Thr Phe Phe Val Leu Ile 20 25 30 Leu Val Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu

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Val Thr 50 Ile Leu Asp Ser His 55 Leu His Thr Pro Met Tyr Phe Phe 60 Leu Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro 65 70 75 80 Leu Ile Leu Asp Ser Phe Leu Thr Pro Arg Lys Thr Ile Pro Phe Ser 85 90 95 Ala Cys Val Met Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu 100 105 110 Cys Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro 130 135 140 Met Ala Ala Ser Ser Trp Ala Ala Gly Ile Thr Asn Ser Val Val Gln 145 150 155 160 Thr Ser Gln Ala Met Arg Leu Pro Phe Cys Gly Asp Asn Val Ile Asn 165 170 175 His Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp 180 185 190 Ile Ser Ile Asn Val Ile Ser Met Val Val Ala Asn Val Ile Phe Leu 195 200 205 Gly Val Pro Val Val Phe Ile Phe Val Ser Tyr Val Phe Ile Ile Ala 210 215 220 Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ala His Leu Thr Val Val Val Val Phe Tyr Gly Thr Ile

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Leu Phe Met 245 250 Lys Asp Pro Gln 255 Tyr 260 Gly Lys Pro Lys Ser 265 Gly 270 Ala Asp Lys Gln Asp Ile Ser Asp Lys Leu Thr Ser Leu Phe Tyr Gly Val Val 275 280 285 Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val 290 295 300 Lys Ala Ala Met Lys Asn Leu Val Cys Gln 305 310

<210> 145 <211> 984 <212> DNA <213> Canis familiaris <400> 145

atgttccagg caaatttgac atatgtaaca cattttttcc tcctggggtt ttcccactac 60 cccaaagttg aggtcatcgt atttgtgctg tgcttgctga tgtatctgat caccctgctg 120 ggtaatataa ttctgatctc catcaccatc ctggattccc acctacacaa acccatgtac 180 ttcttcctca gcaacctctc ctttttagac atctggtaca cctcttctgc tttcactcca 240 atgctggcaa attttgtttc aggggaatac accatctcat tcttagggtg tgctgctcag 300 atgtactttt ctcttgccat gggttccact gagtgtgtgc tcctgtccat gatggcatat 360 gaccggtatg tggccatatg caaccccttg agatacccca tcatcatgaa caagagggtt 420 tgtgtgcaga ttgcagctgg ctcctgggtg acaggctgcc tcaccaccct ggtggaaaca 480 gtatatgtgc tgcagctctc tctgtgtggt aataatacaa tcaatcattt tgcttgtgaa 540 attctggctg tcttgaaact ggtttgtgtg gacacctcca tggtggaatt aatcatgctg 600 gtgatcacca tatttctcct ccctatgcca atgcttctaa tttgtatatc ttatgcgttc 660 attctctcca acatcctaag aatcagctct gtggatggtc gaagcaaagc cttttcaaca 720 tgtgcagccc acctgactgt ggtggttttg ttctatggga cagctctctc catgtacctg 780 aagccctcag ctgtagattc acaggaaata gataaattta tagctttggt atatggtgga 840

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069269_0225_SL.TXT ttaaccccta tgttgaatcc tatcatctat agtctacgaa acaaagaggt gaaagcagcc gtgaaaaaat tgctgattag aaatcctttt ggtactgtgt taatttctgc cctcaataat attggagcaa gcacactccc ctga

900

960

984 <210> 146 <211> 327 <212> PRT <213> Canis familiaris <400> 146

Met Phe 1 Gln Ala Asn Leu Thr Tyr Val Thr His Phe Phe Leu Leu Gly 5 10 15 Phe Ser His Tyr Pro Lys Val Glu Val Ile Val Phe Val Leu Cys Leu 20 25 30 Leu Met Tyr Leu Ile Thr Leu Leu Gly Asn Ile Ile Leu Ile Ser Ile 35 40 45 Thr Ile Leu Asp Ser His Leu His Lys Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Ile Trp Tyr Thr Ser Ser Ala Phe Thr Pro 65 70 75 80 Met Leu Ala Asn Phe Val Ser Gly Glu Tyr Thr Ile Ser Phe Leu Gly 85 90 95 Cys Ala Ala Gln Met Tyr Phe Ser Leu Ala Met Gly Ser Thr Glu Cys 100 105 110 Val Leu Leu Ser Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Ile Ile Met Asn Lys Arg Val Cys Val Gln Ile 130 135 140 Ala Ala Gly Ser Trp Val Thr Gly Cys Leu Thr Thr Leu Val Glu Thr 145 150 155 160

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Val Tyr Val Leu Gln Leu Ser Leu Cys Gly Asn Asn Thr Ile Asn His 165 170 175 Phe Ala Cys Glu Ile Leu Ala Val Leu Lys Leu Val Cys Val Asp Thr 180 185 190 Ser Met Val Glu Leu Ile Met Leu Val Ile Thr Ile Phe Leu Leu Pro 195 200 205 Met Pro Met Leu Leu Ile Cys Ile Ser Tyr Ala Phe Ile Leu Ser Asn 210 215 220 Ile Leu Arg Ile Ser Ser Val Asp Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ala His Leu Thr Val Val Val Leu Phe Tyr Gly Thr Ala Leu 245 250 255 Ser Met Tyr Leu Lys Pro Ser Ala Val Asp Ser Gln Glu Ile Asp Lys 260 265 270 Phe Ile Ala Leu Val Tyr Gly Gly Leu Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Val Lys Lys Leu 290 295 300 Leu Ile Arg Asn Pro Phe Gly Thr Val Leu Ile Ser Ala Leu Asn Asn 305 310 315 320 Ile Gly Ala Ser Thr Leu Pro

325 <210> 147 <211> 939 <212> DNA <213> Canis familiaris <400> 147

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atggggaatt actcagctgt gactgaattc tttttggtgg gactttccca atacccagag 60 ctccagcttt ttctgttcat gctctgcctc atcatgtatg tgataattct gctgggaaat 120 agcctcctca tcatcagcag catactggat tctcgcctcc acacccccat gtacttcttc 180 cttgggaatc tctcgttctt ggacatctgt tacacatcct cttttattcc tacgatgctc 240 accatattta ggtctgagaa aaaatccatc tccttcattg gctgtgctct gcagatggtt 300 gtctcccttg ggttgggctg cactgaatgt gtcctcttgg ctgtgatggc ctatgatcgg 360 tacgtggcca tctgcaaccc actgaggtat cccatcgtca tgaacagggt gctttatgtg 420 cacatggctg cgtggtcctg gatcataggc tgtctaaact ccctagttca aacagtgcta 480 ataatgttgt tgcctttctg tgggaataat gtcattgacc atcttacctg tgagttactg 540 gcccttctta aactcatatg ttcagatatt tccatgaatg tgcttattat gacagtggca 600 agtattcttt tcttagtggt tcccctactg ctaattttta tttcatatgt tttcattctc 660 tctaccattc tgagacttaa ctctactgag gggagaaaga aagccttttc aacgtgttca 720 gcccacctcg ctgtagtagt tttattctat ggttcagcct tatttatgta catgaagccc 780 aagtcaaaag acacaaagac aattgatgag atcatcgggc tgtcttatgg agtggtaacc 840 ccaatgttga accccatcat ctacagccta aggaataagg aagtgaaaga ggctatgaag 900 aaagtcttga gtagacactt tcattcacgg aaaatatga 939

<210> 148 <211> 312 <212> PRT <213> Canis familiaris <400> 148

Met 1 Gly Asn Tyr Ser Ala Val Thr Glu Phe Phe Leu Val Gly Leu Ser 5 10 15 Gln Tyr Pro Glu Leu Gln Leu Phe Leu Phe Met Leu Cys Leu Ile Met 20 25 30 Tyr Val Ile Ile Leu Leu Gly Asn Ser Leu Leu Ile Ile Ser Ser Ile 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu

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50 55 60

Ser 65 Phe Leu Asp Ile Cys Tyr Thr 70 Ser Ser Phe 75 Ile Pro Thr Met Leu 80 Thr Ile Phe Arg Ser Glu Lys Lys Ser Ile Ser Phe Ile Gly Cys Ala 85 90 95 Leu Gln Met Val Val Ser Leu Gly Leu Gly Cys Thr Glu Cys Val Leu 100 105 110 Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 115 120 125 Arg Tyr Pro Ile Val Met Asn Arg Val Leu Tyr Val His Met Ala Ala 130 135 140 Trp Ser Trp Ile Ile Gly Cys Leu Asn Ser Leu Val Gln Thr Val Leu 145 150 155 160 Ile Met Leu Leu Pro Phe Cys Gly Asn Asn Val Ile Asp His Leu Thr 165 170 175 Cys Glu Leu Leu Ala Leu Leu Lys Leu Ile Cys Ser Asp Ile Ser Met 180 185 190 Asn Val Leu Ile Met Thr Val Ala Ser Ile Leu Phe Leu Val Val Pro 195 200 205 Leu Leu Leu Ile Phe Ile Ser Tyr Val Phe Ile Leu Ser Thr Ile Leu 210 215 220 Arg Leu Asn Ser Thr Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ala His Leu Ala Val Val Val Leu Phe Tyr Gly Ser Ala Leu Phe Met 245 250 255 Tyr Met Lys Pro Lys Ser Lys Asp Thr Lys Thr Ile Asp Glu Ile Ile

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069269_0225_SL.TXT 265 270

Gly Leu Ser Tyr Gly Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Met Lys Lys Val Leu Ser 290 295 300 Arg His Phe His Ser Arg Lys Ile 305 310

<210> 149 <211> 954 <212> DNA <213> Canis familiaris <400> 149

atggaacaca tgaagatgga gaattactca gttgtgactg aattctttct ggtgggactt 60 tcccaatacc cagagctcca gctttttctg ttcatgctct gcctcatcat gtatgtgata 120 attctgctgg gaaatagcct cctcatcatc agcagcatac tggattctcg cctccacacc 180 cccatgtact tcttccttgg gaatctctca ttcctggaca tttgttacac atcttctttt 240 attcctacaa tgctcatttt atttaggtct gaaacaaaat ctatctcctt cattggctgt 300 gctctacaga tggtagtctc ccttgggtta ggctgcactg agtgtgtcct cctggctgtg 360 atggcctatg atcggtacgt ggccatctgc aacccactga ggtatcccat catcatgaac 420 agggtgcttt atgtgcacat ggctgcgtgg tcctggatca taggctatct gatctcccta 480 ctgcaaacag tcatgacaat gatattgcct ttctgtggga ataatgtcat tgatcatatt 540 acctgtgaga tcctggccct tcttaaactc atctgctcag atatcaccat caatgtgatt 600 attatgacag tggcaagtat tgttatactg atgcttcctc tactgttaat tttcatctcc 660 tatgttttta tcctctcttc catcctgaga attaattctg ctgaggggag aaagaaagct 720 ttttctacct gctcagccca cctgactgtg gttatcttgt tctatggttc agcccttttt 780 atgtacatga agcccaagtc aaaggacaca aacacttctg atgagatcgt cgtgctgtct 840 tatggcgtga taacgccgat gttgaacccc atcatttaca gcttgagaaa taaggaggtg 900 aaagaggctg tgaagaaagt cctgagcaga cacctacatt tattgaaatc atga 954

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069269_0225_SL.TXT <210> 150 <211> 317 <212> PRT <213> Canis familiaris <400> 150

Met 1 Glu His Met Lys 5 Met Glu Asn Tyr Ser Val Val Thr Glu Phe Phe 10 15 Leu Val Gly Leu Ser Gln Tyr Pro Glu Leu Gln Leu Phe Leu Phe Met 20 25 30 Leu Cys Leu Ile Met Tyr Val Ile Ile Leu Leu Gly Asn Ser Leu Leu 35 40 45 Ile Ile Ser Ser Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Phe 65 70 75 80 Ile Pro Thr Met Leu Ile Leu Phe Arg Ser Glu Thr Lys Ser Ile Ser 85 90 95 Phe Ile Gly Cys Ala Leu Gln Met Val Val Ser Leu Gly Leu Gly Cys 100 105 110 Thr Glu Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys Asn Pro Leu Arg Tyr Pro Ile Ile Met Asn Arg Val Leu Tyr 130 135 140 Val His Met Ala Ala Trp Ser Trp Ile Ile Gly Tyr Leu Ile Ser Leu 145 150 155 160 Leu Gln Thr Val Met Thr Met Ile Leu Pro Phe Cys Gly Asn Asn Val 165 170 175

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Ile Asp His Ile 180 Thr Cys Glu 069269_0225_SL.TXT Ile Leu Ala Leu Leu Lys 185 Leu 190 Ile Cys Ser Asp Ile Thr Ile Asn Val Ile Ile Met Thr Val Ala Ser Ile Val 195 200 205 Ile Leu Met Leu Pro Leu Leu Leu Ile Phe Ile Ser Tyr Val Phe Ile 210 215 220 Leu Ser Ser Ile Leu Arg Ile Asn Ser Ala Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ala His Leu Thr Val Val Ile Leu Phe Tyr Gly 245 250 255 Ser Ala Leu Phe Met Tyr Met Lys Pro Lys Ser Lys Asp Thr Asn Thr 260 265 270 Ser Asp Glu Ile Val Val Leu Ser Tyr Gly Val Ile Thr Pro Met Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Val 290 295 300 Lys Lys Val Leu Ser Arg His Leu His Leu Leu Lys Ser 305 310 315

<210> 151 <211> 945 <212> DNA <213> Canis familiaris <400> 151 atgaagatgg agaattactc agctgtgact gaattctttc tggtgggtct ttcccaatac ccagagctcc agctttttct gttcatgctc tgcctcatca tgtatgtgat aattctgctg ggaaatagcc tcatcatcat catcagcata ctggattctc gcctccacac ccccatgtac ttcttccttg ggaatctctc attcctggac atttgttata catcatcatc tattcctcca atgctcatca tgtttaggtc tgagacaaaa tctatctcct tcattggctg tgctctgcag

120

180

240

300

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atggttgcct cccttgggtt gggctctact gagtgtgtcc tcctggctgt gatggcctat 360 gatcggtacg tggccatctg caacccactg aggtatccca tcatcatgaa cagggtgctt 420 tatgtgcaca tggctgcgtg gtcctggatc ataggctgtc tgaactctct cgtgcaaaca 480 gccctgacaa tggttttgcc tttctgtggg aataatgtca tcgaccatct tacctgtgag 540 atcctggccc ttcttaaact catctgctca gatatctcca tgaatgtgct tatcatgaca 600 gtggcaagta ttgttttatt ggtgcttcct ctattgttaa ttttcatctc ctatgttttt 660 atcctctctt ccatcctgag aattaattct gctgagggga gaaagaaagc tttttctacc 720 tgctcagccc acctgactgt ggttatcttg ttctatggtt cagccctttt tatgtacatg 780 aagcccaagt caaaggacac aaaagcatct gatgaaatca tcgggctgtc ttatggagtg 840 ataaccccaa tgttgaaccc catcatttac agcttgagaa ataaggaggt gaaagaggct 900 gtgaagaaag tcctgagcag acacttgcat ctatggaaaa tataa 945

<210> 152 <211> 314 <212> PRT <213> Canis familiaris <400> 152

Met 1 Lys Met Glu Asn Tyr 5 Ser Ala Val Thr Glu Phe Phe Leu Val Gly 10 15 Leu Ser Gln Tyr Pro Glu Leu Gln Leu Phe Leu Phe Met Leu Cys Leu 20 25 30 Ile Met Tyr Val Ile Ile Leu Leu Gly Asn Ser Leu Ile Ile Ile Ile 35 40 45 Ser Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Ile Pro Pro 65 70 75 80 Met Leu Ile Met Phe Arg Ser Glu Thr Lys Ser Ile Ser Phe Ile Gly 85 90 95

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Cys Ala Leu Gln 100 Met Val Ala Ser Leu Gly Leu Gly Ser Thr Glu Cys 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Ile Ile Met Asn Arg Val Leu Tyr Val His Met 130 135 140 Ala Ala Trp Ser Trp Ile Ile Gly Cys Leu Asn Ser Leu Val Gln Thr 145 150 155 160 Ala Leu Thr Met Val Leu Pro Phe Cys Gly Asn Asn Val Ile Asp His 165 170 175 Leu Thr Cys Glu Ile Leu Ala Leu Leu Lys Leu Ile Cys Ser Asp Ile 180 185 190 Ser Met Asn Val Leu Ile Met Thr Val Ala Ser Ile Val Leu Leu Val 195 200 205 Leu Pro Leu Leu Leu Ile Phe Ile Ser Tyr Val Phe Ile Leu Ser Ser 210 215 220 Ile Leu Arg Ile Asn Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Leu Phe Tyr Gly Ser Ala Leu 245 250 255 Phe Met Tyr Met Lys Pro Lys Ser Lys Asp Thr Lys Ala Ser Asp Glu 260 265 270 Ile Ile Gly Leu Ser Tyr Gly Val Ile Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Val Lys Lys Val 290 295 300

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Leu Ser Arg His Leu His Leu Trp Lys Ile 305 310 <210> 153 <211> 957 <212> DNA <213> Canis familiaris <400> 153

atggatagta taaacaagac atttgtgaaa gaattcattc ttctgggact ctccggttac 60 ccaacacttg agatcatgtt tttttctctg attctagtaa tgtatctagt gattctaatt 120 ggcaatggtc ttctgattat agcaagcatc ttcgattccc atcttcacac ccccatgtac 180 ttcttcctgg gtaacctctc tttcctggac atctgctata catcctcctc tgttccctca 240 actttggtga gcttaatttc aaagaaaagg aacatttcct tctctgggtg tgcagtgcag 300 atgttctttg ggtttgcaat ggggtcaaca gagtgtttcc tccttggcat gatggctttt 360 gatcgctacg tagctatctg taaccctctg agataccctg tcatcatgaa caagatggtg 420 tatgtactaa tggcttctgt gtcatggctc tctggtggaa tcaactcaat tgtacaaaca 480 tctcttgcta tgcgactgcc tttctgtggg aataatatta tcaatcattt cttatgtgag 540 atactagctg tcttaaagct agcctgcgct gatatatccc tcaatatttt taccctagca 600 gtgtcaaata tggcattcct ggttcttcca ctgctggtca tttttttctc ctatatgttt 660 atcctctaca ccatcttgag aatgaactca gctacaggga gacgcaaagc cttttccacc 720 tgctcagcac atctgaccgt ggtgatcata ttttatggta ccatcttctt catgtatgcc 780 aagcccaagt ctcaagacca cctagggaat gacaatttgc aagctacgga agggcttatt 840 tccatgtttt atggggtagt gacccctatg ctaaatccta taatctatag cttgagaaat 900 aaggatgtaa aagcggctgt gaaatatgtg ctgaattgga aagctgttaa gcagtaa 957

<210> 154 <211> 318 <212> PRT <213> Canis familiaris <400> 154

Met Asp Ser Ile Asn Lys Thr Phe Val Lys Glu Phe Ile Leu Leu Gly 1 5 10 15

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Leu Ser Gly Tyr 20 Pro Thr Leu Glu Ile Met Phe Phe Ser Leu Ile Leu 25 30 Val Met Tyr Leu Val Ile Leu Ile Gly Asn Gly Leu Leu Ile Ile Ala 35 40 45 Ser Ile Phe Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Ser 65 70 75 80 Thr Leu Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly 85 90 95 Cys Ala Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys 100 105 110 Phe Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Ile Met Asn Lys Met Val Tyr Val Leu Met 130 135 140 Ala Ser Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Ile Val Gln Thr 145 150 155 160 Ser Leu Ala Met Arg Leu Pro Phe Cys Gly Asn Asn Ile Ile Asn His 165 170 175 Phe Leu Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Leu Asn Ile Phe Thr Leu Ala Val Ser Asn Met Ala Phe Leu Val 195 200 205 Leu Pro Leu Leu Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr 210 215 220

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Ile 225 Leu Arg Met Asn Ser Ala Thr Gly Arg Arg Lys Ala Phe Ser Thr 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe 245 250 255 Phe Met Tyr Ala Lys Pro Lys Ser Gln Asp His Leu Gly Asn Asp Asn 260 265 270 Leu Gln Ala Thr Glu Gly Leu Ile Ser Met Phe Tyr Gly Val Val Thr 275 280 285 Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Ala Ala Val Lys Tyr Val Leu Asn Trp Lys Ala Val Lys Gln 305 310 315

<210> 155 <211> 954 <212> DNA <213> Canis familiaris <400> 155

atggatgaaa ttaatcagac atctgcatca gaatttcttc ttctgggact cgctggttac 60 ccaacacttg agatcattta cttcgttcta attctagtaa tgtatctagt gattctaatt 120 ggcaatggtc ttctgattat agcaagcatc ttcgattctc atcttcacac ccccatgtac 180 ttcttcctgg gtaacctctc tttcctggac atctgctata catcttcctc tgttccctca 240 acattggtga gcttaatttc aaagaaaagg aacatttcct tctctgggtg tgcagtgcag 300 atgttccttg ggtttgcaat gggatcaaca gagtgtttgc tccttggcat gatggctttt 360 gatcgctacg tagctatctg taaccctctg agatacctca tcatcatgaa caaggtggtg 420 tatgtactaa tggcttctgt gtcatggctc tctggtggaa tcaactcaat tgtacaaaca 480 tttcttgcca tgcgactgcc tttctgtggg aataatatta tcaatcattt cacgtgtgaa 540 atattagctg tccttaagct agcttgtgct gatatatccc tcaatattgt caccatggtg 600

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atatcaaata tggcattcct ggttcttcca ctgctggtca tttttttctc ctatatgttc 660 atcctctaca ccatcttgag aatgaactca gctacaggga gacacaaggc cttttccacc 720 tgctcagcac atctgactgt ggtgatcata ttttatggta ccatcttctt catgtatgcc 780 aagcccaagt cccaagaatt gcctggagaa gacaagtttc aaacttcaga caagctcatt 840 tccctgtttt atggggtagt gacccctatg ctaaatccta taatctatag cttgaggaat 900 aaggatgtaa aaactgctgt aaaatatctg ctgaaccgaa aacctattcg gtaa 954

<210> 156 <211> 317 <212> PRT <213> Canis familiaris <400> 156

Met 1 Asp Glu Ile Asn Gln Thr Ser Ala Ser Glu Phe Leu Leu Leu Gly 5 10 15 Leu Ala Gly Tyr Pro Thr Leu Glu Ile Ile Tyr Phe Val Leu Ile Leu 20 25 30 Val Met Tyr Leu Val Ile Leu Ile Gly Asn Gly Leu Leu Ile Ile Ala 35 40 45 Ser Ile Phe Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Ser 65 70 75 80 Thr Leu Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Ser Phe Ser Gly 85 90 95 Cys Ala Val Gln Met Phe Leu Gly Phe Ala Met Gly Ser Thr Glu Cys 100 105 110 Leu Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Leu Ile Ile Met Asn Lys Val Val Tyr Val Leu Met

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130 135 069269_0225_SL.TXT 140 Ala Ser Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Ile Val Gln Thr 145 150 155 160 Phe Leu Ala Met Arg Leu Pro Phe Cys Gly Asn Asn Ile Ile Asn His 165 170 175 Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Leu Asn Ile Val Thr Met Val Ile Ser Asn Met Ala Phe Leu Val 195 200 205 Leu Pro Leu Leu Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr 210 215 220 Ile Leu Arg Met Asn Ser Ala Thr Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe 245 250 255 Phe Met Tyr Ala Lys Pro Lys Ser Gln Glu Leu Pro Gly Glu Asp Lys 260 265 270 Phe Gln Thr Ser Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr 275 280 285 Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Thr Ala Val Lys Tyr Leu Leu Asn Arg Lys Pro Ile Arg 305 310 315

<210> 157 <211> 960 <212> DNA <213> Canis familiaris

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069269_0225_SL.TXT <400> 157

atggaaagga ccaatgattc catgttgaca gaatttgtcc ttgttgggct ttctgcccac 60 ccaaagctcc agacagtttt ctttgtgcta gttttgtgga tgtacctgat gatccttcta 120 ggaaatggag tccttatttc agtaatcatc tatgattctc acttgcacac ccccatgtat 180 ttcttcctct gtaatctttc gttcctggac atttgttata caagttcctc tgtgccacta 240 attcttgaca actttctgag agtaaggaaa agggtttcct tctctgggtg catggtgcaa 300 atgtttctct catttgccat gggggccaca gagtgtgtgc ttctaggcat gatggcactt 360 gaccgcttgg tagccatctg ctacccactg agataccctg tcatcatgag caaaaatacc 420 tatatgctca tggcagctgg atcctgggtc actgggttta ttgactcagt ggtgcagaca 480 tctctcgcaa tgcagttgcc attctgtgct aataatgtca ttaaccattt tgtctgtgaa 540 attctggcta tcctaaaact ggcctgtgct gatatttcaa tcaatgtgat cagtatggca 600 gggtcaaatc tgatgggtct ggttattcca ctgctagtaa tttctatctc ttacattttt 660 attctcacca ctattctgaa gatttcttcc actgaaggaa aacgtaaggc cttctccact 720 tgctcagccc acctaacagt agtgattata ttctatggaa ccctcttctt catgtacgca 780 aagcccaaat ctaaaagctc tgttggtgcc aataatcaag acatcactga ggccctcatc 840 tctctcttct atggagtaat gactcccatg ctcaatcctc tcatctatag tctgaggaac 900 aaggatgtaa aggctgctgt gaagaacatg ttggggagaa gaaactctga tggaatatga 960

<210> 158 <211> 319 <212> PRT <213> Canis familiaris <400> 158

Met Glu Arg 1 Thr Asn 5 Asp Ser Met Leu Thr Glu Phe Val Leu Val Gly 10 15 Leu Ser Ala His Pro Lys Leu Gln Thr Val Phe Phe Val Leu Val Leu 20 25 30 Trp Met Tyr Leu Met Ile Leu Leu Gly Asn Gly Val Leu Ile Ser Val 35 40 45

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Ile Ile 50 Tyr Asp Ser His Leu 55 069269_0225_SL.TXT His Thr Pro Met Tyr Phe 60 Phe Leu Cys Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Leu 65 70 75 80 Ile Leu Asp Asn Phe Leu Arg Val Arg Lys Arg Val Ser Phe Ser Gly 85 90 95 Cys Met Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 100 105 110 Val Leu Leu Gly Met Met Ala Leu Asp Arg Leu Val Ala Ile Cys Tyr 115 120 125 Pro Leu Arg Tyr Pro Val Ile Met Ser Lys Asn Thr Tyr Met Leu Met 130 135 140 Ala Ala Gly Ser Trp Val Thr Gly Phe Ile Asp Ser Val Val Gln Thr 145 150 155 160 Ser Leu Ala Met Gln Leu Pro Phe Cys Ala Asn Asn Val Ile Asn His 165 170 175 Phe Val Cys Glu Ile Leu Ala Ile Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Val Ile Ser Met Ala Gly Ser Asn Leu Met Gly Leu Val 195 200 205 Ile Pro Leu Leu Val Ile Ser Ile Ser Tyr Ile Phe Ile Leu Thr Thr 210 215 220 Ile Leu Lys Ile Ser Ser Thr Glu Gly Lys Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Leu Phe 245 250 255

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Phe Met Tyr Ala 260 Lys Pro Lys 069269_0225_SL.TXT Ser Lys Ser Ser Val Gly 265 Ala 270 Asn Asn Gln Asp Ile Thr Glu Ala Leu Ile Ser Leu Phe Tyr Gly Val Met Thr 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Ala Ala Val Lys Asn Met Leu Gly Arg Arg Asn Ser Asp Gly Ile 305 310 315

<210> 159 <211> 939 <212> DNA <213> Canis familiaris <400> 159

atggacagga caaattggac agagattgag ttcattctgc agggactttc tgagtaccca 60 agagtggaaa aactcctttt tgtgatgtgc ttgatgatgt acctggtgat cctgctggga 120 aacagcacct tgatcatcct aactctcctg gattcccggc tccatacacc catgtacttc 180 ttccttggta atctttcctt cctagacatt tggtacacat cctcctttat cccctcaatg 240 ttgatacact tcctatcaca gaaaaaaacc atctcctttg ctagatgtgt tattcagatg 300 tctgcctcct acactatggg gtccacagag tgtgtgctcc tagcagtgat ggcatatgac 360 cgttatgtgg ccatctgtaa ccctctgaga tactccatca tcatgagcaa ggcactgtgt 420 attcagatgg cagctctctc ctggggattg ggctttctca attcactgac agaaactgtt 480 cttgcaatac ggctgccctt ctgtggaaaa aatgtcatta accactttgc ttgtgaaata 540 ttggcctttg tcaagctggc ttgtacagat atttccttga atgagattac tataatgttg 600 ggaaatgtaa tatttttatt ttccccattg ctgttaattt gtatctccta cattttcatc 660 ctttctactg tactaagaat caattcagta gaaggaagga aaaaggcctt ttctatctgc 720 tcagcccact taacagtagt gactttgttt tatgggacaa tcctcttcat gtatatgaag 780 ccaaagtcca aagactctgc ttttaataaa ttgattgctc tgttctatgg agtagtcact 840 cccatgctca accctatcat ctatagcctg aggaatacag aggtacatgg agctatgaga 900

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069269_0225_SL.TXT aaattgatga ctaaacactc atattggaga aaaggatga <210> 160 <211> 312 <212> PRT <213> Canis familiaris <400> 160

Met 1 Asp Arg Thr Asn 5 Trp Thr Glu Ile Glu Phe Ile Leu Gln Gly Leu 10 15 Ser Glu Tyr Pro Arg Val Glu Lys Leu Leu Phe Val Met Cys Leu Met 20 25 30 Met Tyr Leu Val Ile Leu Leu Gly Asn Ser Thr Leu Ile Ile Leu Thr 35 40 45 Leu Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn 50 55 60 Leu Ser Phe Leu Asp Ile Trp Tyr Thr Ser Ser Phe Ile Pro Ser Met 65 70 75 80 Leu Ile His Phe Leu Ser Gln Lys Lys Thr Ile Ser Phe Ala Arg Cys 85 90 95 Val Ile Gln Met Ser Ala Ser Tyr Thr Met Gly Ser Thr Glu Cys Val 100 105 110 Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125 Leu Arg Tyr Ser Ile Ile Met Ser Lys Ala Leu Cys Ile Gln Met Ala 130 135 140 Ala Leu Ser Trp Gly Leu Gly Phe Leu Asn Ser Leu Thr Glu Thr Val 145 150 155 160 Leu Ala Ile Arg Leu Pro Phe Cys Gly Lys Asn Val Ile Asn His Phe 165 170 175

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Ala Cys Glu Ile 180 Leu Ala Phe Val Lys 185 Leu Ala Cys Thr Asp Ile Ser 190 Leu Asn Glu Ile Thr Ile Met Leu Gly Asn Val Ile Phe Leu Phe Ser 195 200 205 Pro Leu Leu Leu Ile Cys Ile Ser Tyr Ile Phe Ile Leu Ser Thr Val 210 215 220 Leu Arg Ile Asn Ser Val Glu Gly Arg Lys Lys Ala Phe Ser Ile Cys 225 230 235 240 Ser Ala His Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Ile Leu Phe 245 250 255 Met Tyr Met Lys Pro Lys Ser Lys Asp Ser Ala Phe Asn Lys Leu Ile 260 265 270 Ala Leu Phe Tyr Gly Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Thr Glu Val His Gly Ala Met Arg Lys Leu Met Thr 290 295 300 Lys His Ser Tyr Trp Arg Lys Gly

305 310 <210> 161 <211> 942 <212> DNA <213> Canis familiaris <400> 161

atgatcaaga caaacttgac agtcatttca aaatttattt ttctgggatt tacttactac 60 cccaaagttg aggtcatcgt atttgtgcta tgcttgctga tgtatctgat caccctgctg 120 ggtaatataa ttctgatctc catcaccatc ctggattccc acctacacaa acccatgtac 180 ttctttctca gcaacctctc ctttttagac atctggtaca cctcttctgc tctcactcca 240 atgctggcaa actttgttct ggggaaaaac actatctcat tctcaggatg tgccattcag 300

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atgtactttt ctcttgccat gggctccact gagtgtgtgc tcctctccat gatggcgtat 360 gaccggtatg tggccatctg caaccctctg aggtaccctg tcatcatgaa taggagggtt 420 tgtgtgcaga ttgcagctgg ctcctgggtg acaggctgcc tcactgcctt ggtggaaaca 480 atgtctgtgc tgcatcagtc tctctgtgga aatagcatca tcaatcattt cacttgtgaa 540 attctggctg tgttgaaact agtttgcgta gacacttcca gggtgcagtt aatcatgctg 600 ttgattagcg tacttcttct tcctatgccg atgcttctca tttgtatatc ttatgcgttc 660 attctctcca acattctgag aatcagctca gtggatggtc gaagcaaagc cttttcaaca 720 tgtgcagccc acttgactgt ggtggttttg ttctatggga cagctctctc catgtacctg 780 aagcccttgg ctgtggattc acaagaaata gataaattta tagctctggt atatgctggg 840 ttaaccccca tgttgaatcc tatcatttat agtctacgga acaaagaggt gaaagcagct 900 gtgaaaaaat tgctgattag gaaccctctt tgtgcttttt aa 942

<210> 162 <211> 313 <212> PRT <213> Canis familiaris <400> 162

Met Ile Lys Thr Asn Leu Thr Val Ile Ser Lys Phe Ile Phe Leu Gly 1 5 10 15 Phe Thr Tyr Tyr Pro Lys Val Glu Val Ile Val Phe Val Leu Cys Leu 20 25 30 Leu Met Tyr Leu Ile Thr Leu Leu Gly Asn Ile Ile Leu Ile Ser Ile 35 40 45 Thr Ile Leu Asp Ser His Leu His Lys Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Ile Trp Tyr Thr Ser Ser Ala Leu Thr Pro 65 70 75 80 Met Leu Ala Asn Phe Val Leu Gly Lys Asn Thr Ile Ser Phe Ser Gly 85 90 95

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Cys Ala Ile Gln 100 Met Tyr Phe Ser Leu Ala Met Gly Ser Thr Glu Cys 105 110 Val Leu Leu Ser Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Ile Met Asn Arg Arg Val Cys Val Gln Ile 130 135 140 Ala Ala Gly Ser Trp Val Thr Gly Cys Leu Thr Ala Leu Val Glu Thr 145 150 155 160 Met Ser Val Leu His Gln Ser Leu Cys Gly Asn Ser Ile Ile Asn His 165 170 175 Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Val Cys Val Asp Thr 180 185 190 Ser Arg Val Gln Leu Ile Met Leu Leu Ile Ser Val Leu Leu Leu Pro 195 200 205 Met Pro Met Leu Leu Ile Cys Ile Ser Tyr Ala Phe Ile Leu Ser Asn 210 215 220 Ile Leu Arg Ile Ser Ser Val Asp Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ala His Leu Thr Val Val Val Leu Phe Tyr Gly Thr Ala Leu 245 250 255 Ser Met Tyr Leu Lys Pro Leu Ala Val Asp Ser Gln Glu Ile Asp Lys 260 265 270 Phe Ile Ala Leu Val Tyr Ala Gly Leu Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Val Lys Lys Leu 290 295 300

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Leu Ile Arg Asn Pro Leu Cys Ala Phe 305 310 <210> 163 <211> 975 <212> DNA <213> Canis familiaris <400> 163

atggaatggg aaaatcaaac cattctggtg gaattctttt tgaaggggct ttctggttac 60 cctaagcttg agctactctt ttttgtgctg atcttaataa tgtatgttgt catccttctg 120 ggcaatggca cccttatttt aatcagcgtc ttggactccc accttcacac ccctatgtac 180 ttcttcctgg ggaacctctc cttcttggac atctgctaca ccaccacctc cattccctcc 240 acgctggtga gcttcctctc agaaagaaag accatctcct tctctggctg tgcagtgcag 300 atgttccttg gcttggccat ggggacaaca gagtgtgtgc tcctgggcat gatggccttt 360 gaccggtatg tggctatctg caacccccta agatatcctg tcatcatgag caaggactcc 420 tatgtgccca tggcaactgg gtcctggatc ataggactgg tcaactctgc agtacaaacg 480 gcgtttgtgg tacaattgcc tttctgtagg aataatgtca tcaatcattt ctcctgtgaa 540 attctggctg tcatgaaact ggcttgtgct gacatctcag gcaatgagtt catcatgctc 600 gtggccacga cattgtttat attgacacca ctgctattaa ttattatctc ctactcatta 660 atcatctcta gtatcctcaa gattcgcact tctgagggga gaagcaaagt cttctccact 720 tgctcagccc acctgactgt ggtgataata ttctatggaa ccattctctt catgtacatg 780 aagcccaaat ctaaaaagac actcaattca gatgacttgg atgcgactga caaacttata 840 tccatgttct atggggttat gactcccatg atgaatcctt taatctacag tctcagaaac 900 aaggatgtga aagaagcagt taaacaccta ctgaagaaaa tgtgtttaac aagtaaatgg 960 gaaagggaca agtaa 975

<210> 164 <211> 324 <212> PRT <213> Canis familiaris

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<400> 164 Glu Phe Phe Leu Lys 15 Gly Met 1 Glu Trp Glu Asn Gln 5 Thr Ile Leu Val 10 Leu Ser Gly Tyr Pro Lys Leu Glu Leu Leu Phe Phe Val Leu Ile Leu 20 25 30 Ile Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile 35 40 45 Ser Val Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser 65 70 75 80 Thr Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Ala Val Gln Met Phe Leu Gly Leu Ala Met Gly Thr Thr Glu Cys 100 105 110 Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Ile Met Ser Lys Asp Ser Tyr Val Pro Met 130 135 140 Ala Thr Gly Ser Trp Ile Ile Gly Leu Val Asn Ser Ala Val Gln Thr 145 150 155 160 Ala Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Val Ile Asn His 165 170 175 Phe Ser Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Gly Asn Glu Phe Ile Met Leu Val Ala Thr Thr Leu Phe Ile Leu 195 200 205

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Thr Pro Leu Leu Leu Ile Ile Ile Ser Tyr Ser Leu Ile Ile Ser Ser 210 215 220 Ile Leu Lys Ile Arg Thr Ser Glu Gly Arg Ser Lys Val Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 245 250 255 Phe Met Tyr Met Lys Pro Lys Ser Lys Lys Thr Leu Asn Ser Asp Asp 260 265 270 Leu Asp Ala Thr Asp Lys Leu Ile Ser Met Phe Tyr Gly Val Met Thr 275 280 285 Pro Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Glu Ala Val Lys His Leu Leu Lys Lys Met Cys Leu Thr Ser Lys Trp 305 310 315 320

Glu Arg Asp Lys <210> 165 <211> 957 <212> DNA <213> Canis familiaris <400> 165

atggaatggg aaaatcaaac cattctggtg gaattctttt tgaaggggct ttctggttac 60 cctaagcttg agctactctt ttttgtgctg atcttaataa tgtatgttgt catccttctg 120 ggcaatggca cccttatttt aatcagcgtc ttggactccc accttcacac ccctatgtac 180 ttcttcctgg ggaacctctc cttcttggac atctgctaca ccaccacctc cattccctcc 240 acgctggtga gcttcctctc agaaagaaag accatctcct tctctggctg tgcagtgcag 300 atgttccttg gcttggccat ggggacaaca gagtgtgtgc tcctgggcat gatggccttt 360 gaccggtatg tggctatctg caacccccta agatatcctg tcatcatgag caaggattcc 420

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tatgtgccca tggcaactgg gtcctggttt gctggggtta tcaactctgc agtacaaacg 480 gcgtttgtgg tacaattgcc tttctgtagg aataacgtca tcaatcattt ctcctgtgaa 540 attctggctg tcatgaaact ggcttgtgct gacatctcag gcaatgagtt catcatgctc 600 gtggccacga cattgttcac cttgctgccc ctgcttttga tcgtcatctc ttactcatta 660 atcatctcta gtatcctcaa gattcgtact tctgagggga gaagcaaagc tttctccacc 720 tgctcagccc acctgactgt ggtgataata ttctatggaa ccattctctt catgtacatg 780 aagcccaaat ctaaagagac acttaattca gatgacttgg atgcgactga caaacttata 840 tccatgttct atggggttat gactcccatg atgaatcctt taatctacag tctcagaaac 900 aaggatgtga aggaggcagt taaacatcta tttagcagaa gattctttag caagtga 957

<210> 166 <211> 318 <212> PRT <213> Canis familiaris <400> 166

Met Glu Trp Glu Asn Gln Thr Ile Leu Val Glu Phe Phe Leu Lys Gly 1 5 10 15 Leu Ser Gly Tyr Pro Lys Leu Glu Leu Leu Phe Phe Val Leu Ile Leu 20 25 30 Ile Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile 35 40 45 Ser Val Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser 65 70 75 80 Thr Leu Val Ser Phe Leu Ser Glu Arg Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Ala Val Gln Met Phe Leu Gly Leu Ala Met Gly Thr Thr Glu Cys 100 105 110

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Val Leu Leu 115 Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 120 125 Pro Leu Arg Tyr Pro Val Ile Met Ser Lys Asp Ser Tyr Val Pro Met 130 135 140 Ala Thr Gly Ser Trp Phe Ala Gly Val Ile Asn Ser Ala Val Gln Thr 145 150 155 160 Ala Phe Val Val Gln Leu Pro Phe Cys Arg Asn Asn Val Ile Asn His 165 170 175 Phe Ser Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Gly Asn Glu Phe Ile Met Leu Val Ala Thr Thr Leu Phe Thr Leu 195 200 205 Leu Pro Leu Leu Leu Ile Val Ile Ser Tyr Ser Leu Ile Ile Ser Ser 210 215 220 Ile Leu Lys Ile Arg Thr Ser Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 245 250 255 Phe Met Tyr Met Lys Pro Lys Ser Lys Glu Thr Leu Asn Ser Asp Asp 260 265 270 Leu Asp Ala Thr Asp Lys Leu Ile Ser Met Phe Tyr Gly Val Met Thr 275 280 285 Pro Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Glu Ala Val Lys His Leu Phe Ser Arg Arg Phe Phe Ser Lys

305 310 315

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069269_0225_SL.TXT <210> 167 <211> 963 <212> DNA <213> Canis familiaris <400> 167

atgggagaga ccaatcagtc ttctgtgaca gaatttgtcc ttttgggact ttctggctat 60 ccagagcttg aggccattta ctttgtgctg gtactgtgta tgtacctggt gatcctgctg 120 ggaaatggag tcatcatcat tgtaagtgtc tgtgacaccc acctacacac ccccatgtac 180 tttttcctca gtaacttatc attcttggat atttgctata ccagttcttc tattccccta 240 tttctcagca gctttttaac atcaaagaaa accatttcct tctctggatg tggagtgcaa 300 atgtttcttt cctttgctat gggagccaca gagtgtgtcc ttctaagcat gatggcattt 360 gaccgctatg tggccatctg taaccctctg agatacccca tcattatgag caagacttca 420 tatgtgccca tggctgctgg gtcctggatc gcaggaggtg tcaattctgt gttgcaaacc 480 tgtcttgcga tgcggcttcc cttctgtggg gataatgtca ttaatcattt tacttgtgaa 540 atcttggctg tcttaaaatt ggcctgtgct gatatctcca taaatatcat tagcatggtt 600 attgctaaca tgatttttct tgtggtccca gtacttttca tttttgtttc ctatgttttc 660 attctctcca ctatcctgaa gattccttct gcagagggga agcgcaaagc cttctccacc 720 tgctctgccc acctaacagt ggtgattata ttctatggaa ccatcctctt catgtatgca 780 aaacccaagg ctaaagactc atctggtgca gacaaagtac aagtcacaga caaaatcatc 840 tctctattct atggagtcgt gacacctatg ctcaatcctc tcatctatag tttgaggaac 900 aaagacgtga aagaagctgt gaagaatgta ctgtgtcgga aatgctcctc agaggcgatg 960

tga 963 <210> 168 <211> 320 <212> PRT <213> Canis familiaris <400> 168

Met Gly Glu Thr Asn Gln Ser Ser Val Thr Glu Phe Val Leu Leu Gly 1 5 10 15

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Leu Ser Gly Tyr 20 Pro Glu Leu Glu Ala Ile Tyr Phe Val Leu Val Leu 25 30 Cys Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Ile Ile Ile Val 35 40 45 Ser Val Cys Asp Thr His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Ile Pro Leu 65 70 75 80 Phe Leu Ser Ser Phe Leu Thr Ser Lys Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Gly Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 100 105 110 Val Leu Leu Ser Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Ile Ile Met Ser Lys Thr Ser Tyr Val Pro Met 130 135 140 Ala Ala Gly Ser Trp Ile Ala Gly Gly Val Asn Ser Val Leu Gln Thr 145 150 155 160 Cys Leu Ala Met Arg Leu Pro Phe Cys Gly Asp Asn Val Ile Asn His 165 170 175 Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Ile Ile Ser Met Val Ile Ala Asn Met Ile Phe Leu Val 195 200 205 Val Pro Val Leu Phe Ile Phe Val Ser Tyr Val Phe Ile Leu Ser Thr 210 215 220

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Ile 225 Leu Lys Ile Pro Ser Ala Glu Gly Lys Arg Lys Ala Phe Ser Thr 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 245 250 255 Phe Met Tyr Ala Lys Pro Lys Ala Lys Asp Ser Ser Gly Ala Asp Lys 260 265 270 Val Gln Val Thr Asp Lys Ile Ile Ser Leu Phe Tyr Gly Val Val Thr 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Glu Ala Val Lys Asn Val Leu Cys Arg Lys Cys Ser Ser Glu Ala Met 305 310 315 320

<210> 169 <211> 951 <212> DNA <213> Canis familiaris <400> 169

atgaaaggag gaaacctcac cgtttggagc ttttttttcc tggagggttt ttctagatac 60 ccgaagttag agattgttct cttcgtcttc agccttgtga tgtatctgat aactctcttg 120 ggcaacagca ctctgatctt gatcactgtc ctagattcac gcctccaaac ccccatgtac 180 tttttccttg gaaatctgtc tttcatggat atctgttaca catctgcatc gattcccact 240 ttgctggtga acttgctctc atcccagaaa accattgtct tttctgggtg catggtacag 300 atgtatttgt ccctcgccat gggctccaca gagtgcgtgc tcctggctgt gatggcatat 360 gaccgttacg tggccatttg ccacccactg agatacccca tcatcataaa caggcaggtc 420 tgtgtgcaga tggccactgt ctcctgggtg acggggtgtg tgaccgccct gctggaaacc 480 agtttcgccc tgcgggtgcc cctctgtagg aatctcatcg atcacttcac gtgtgaaatt 540 ctggccgtgc tgaagttagc ttgcacgagt tcactgctca tggacatgat catgctggtg 600 gtcagcgtgc tcctcctgcc tattccgatg ctcttgattt gcatctctta tgtcttcatc 660

Page 184

069269_0225_SL.TXT ctttccacta ttctgagaat ggtgcccacc tgactgtggt ccttcttcat caagttcaca accccaatgt tgaaccccat agaaaagtac tgggccagac cagctcagcg gagggaagaa gatcttgtat tttggggccg agaagtagat aagatcatct aatttacagc ttaaggaaca accattgtat caaacacatg acaaagcttt ttccacctgt ccctgtctat gtacctaaag cgctgcttta tggagtgctg aagaagtcaa aggtgccgtg aaaatctctg a

720

780

840

900

951 <210> 170 <211> 316 <212> PRT <213> Canis familiaris <400> 170

Met 1 Lys Gly Gly Asn 5 Leu Phe Ser Arg Tyr 20 Pro Lys Val Met Tyr 35 Leu Ile Thr Thr Val 50 Leu Asp Ser Arg Asn 65 Leu Ser Phe Met Asp 70 Leu Leu Val Asn Leu 85 Leu

Leu Gln Thr Pro Met 55

Thr Val Trp Ser Phe 10

Leu Glu Ile Val Leu 25

Leu Leu Gly Asn Ser 40

Ile Cys Tyr Thr Ser 75

Ser Ser Gln Lys Thr 90

Phe Phe Leu Glu 15 Gly Phe Val Phe 30 Ser Leu Thr Leu 45 Ile Leu Ile Tyr 60 Phe Phe Leu Gly Ala Ser Ile Pro Thr 80 Ile Val Phe Ser 95 Gly

Cys Met Val Gln Met Tyr Leu 100

Ser Leu Ala Met Gly 105

Ser Thr Glu 110

Cys

Val

Leu Leu Ala Val Met Ala 115

Tyr Asp Arg Tyr Val Ala 120 125

Ile Cys

His

Pro Leu Arg Tyr Pro Ile Ile Ile Asn 130 135

Arg Gln Val 140

Cys Val Gln Met

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Ala Thr Val Ser Trp Val Thr Gly Cys Val Thr Ala Leu Leu Glu Thr 145 150 155 160 Ser Phe Ala Leu Arg Val Pro Leu Cys Arg Asn Leu Ile Asp His Phe 165 170 175 Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Thr Ser Ser Leu 180 185 190 Leu Met Asp Met Ile Met Leu Val Val Ser Val Leu Leu Leu Pro Ile 195 200 205 Pro Met Leu Leu Ile Cys Ile Ser Tyr Val Phe Ile Leu Ser Thr Ile 210 215 220 Leu Arg Ile Ser Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Ala His Leu Thr Val Val Ile Leu Tyr Phe Gly Ala Ala Leu Ser 245 250 255 Met Tyr Leu Lys Pro Ser Ser Ser Ser Ser Gln Glu Val Asp Lys Ile 260 265 270 Ile Ser Leu Leu Tyr Gly Val Leu Thr Pro Met Leu Asn Pro Ile Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Val Arg Lys Val Leu 290 295 300 Gly Gln Thr Pro Leu Tyr Gln Thr His Glu Asn Leu 305 310 315

<210> 171 <211> 936 <212> DNA <213> Canis familiaris <400> 171

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atgagaaatc acacagcaat aacagagttt attcttcttg gattgacaaa tgacccacag 60 tggcaggttg tacttttcat atttcttttt gttacctaca tgctcagtgt gactgggaac 120 ctgatcatta tcaccctcac tctttcagat ccccacctgc agactccaat gtatttcttc 180 cttcgaaact tctcattcct agaaatatca ttcacgtctg tctgcattcc cagattcctt 240 gtcactatcg tgacaaggga cagaaccatt acttacaatg gttgtgtgac tcagctattt 300 ttcttcatct tcttgggggt gacagaattt taccttctgg ctgccatgtc ctatgaccgc 360 tacgtggcca tctgcaaacc cctgcattac atgactgtca tgagcagcag agtctgcatc 420 cttcttgtct ttagctcatg gcttgcagga ttcctgatca tctttccacc attaatcctg 480 ctgctgcaac tggatttctg tgcctccaat ataattgatc attttatttg tgactcttct 540 ccaattctac agctttcttg tacaaacact cactttctag aactcatggc atttttttta 600 gcggtggtaa cacttatggt caccttaacc ctagttattc tctcttatac atacatcatc 660 cggacaattc tgagaattcc ttctacgagt caaaggaaaa aagccttttc cacatgttcc 720 tcccacatga tagtggtctc cctctcttat ggtagctgta tcttcatgta cattaagcct 780 tctgcaaggg aaagggtaac tttaagcaaa ggagtagctg tgctcaatac ctcagtggct 840 cctctcttga atcctttcat atacacacta agaaaccagc aggtgaagca agccttcaag 900 aacatggttc agagaatggt cttttcaaat aaatga 936 <210> 172 <211> 311 <212> PRT <213> Canis familiaris <400> 172 Met Arg Asn His Thr Ala Ile Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asn Asp Pro Gln Trp Gln Val Val Leu Phe Ile Phe Leu Phe Val Thr 20 25 30 Tyr Met Leu Ser Val Thr Gly Asn Leu Ile Ile Ile Thr Leu Thr Leu 35 40 45 Ser Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe

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50 55 60

Ser 65 Phe Leu Glu Ile Ser Phe Thr Ser Val Cys Ile Pro Arg Phe Leu 70 75 80 Val Thr Ile Val Thr Arg Asp Arg Thr Ile Thr Tyr Asn Gly Cys Val 85 90 95 Thr Gln Leu Phe Phe Phe Ile Phe Leu Gly Val Thr Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Val Met Ser Ser Arg Val Cys Ile Leu Leu Val Phe 130 135 140 Ser Ser Trp Leu Ala Gly Phe Leu Ile Ile Phe Pro Pro Leu Ile Leu 145 150 155 160 Leu Leu Gln Leu Asp Phe Cys Ala Ser Asn Ile Ile Asp His Phe Ile 165 170 175 Cys Asp Ser Ser Pro Ile Leu Gln Leu Ser Cys Thr Asn Thr His Phe 180 185 190 Leu Glu Leu Met Ala Phe Phe Leu Ala Val Val Thr Leu Met Val Thr 195 200 205 Leu Thr Leu Val Ile Leu Ser Tyr Thr Tyr Ile Ile Arg Thr Ile Leu 210 215 220 Arg Ile Pro Ser Thr Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Val Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Lys Pro Ser Ala Arg Glu Arg Val Thr Leu Ser Lys Gly Val

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260

069269_0225_SL.TXT 265 270

Ala Val Leu Asn Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asn Met Val Gln 290 295 300 Arg Met Val Phe Ser Asn Lys

305 310 <210> 173 <211> 927 <212> DNA <213> Canis familiaris <400> 173

atgggcacag acaatgcaac ccgtcaccag gattttctcc tgctgggctt tcctgggtcc 60 caggtccttc agctatctct ctttatgctt tttctggtaa tgtacattct cacagtgggt 120 gggaacatgg ctatcttgat gctggtgagt acctcccacc agctacatac cccgatgtac 180 ttctttctga gcaacctttc tttcttggag atttggtata ccacagctgc agtccccaaa 240 gccctggcca tccttctggg gagaagccaa accataacat ttactggctg ccttttgcag 300 atgtaccttg ttttctcatt gggctgcaca gagtacttcc tcctggcagc catggcttac 360 gaccgctatc tggccatctg ctatcctcta cactatgggg ccatcatgaa tagcctgctc 420 tcagcacagc tagccctggg atcatggctg tgcggttttc tggccatttc agtgcccaca 480 gctctcatca gcaccctgtc cttctgtggt tcccgcacta tcaaccactt cttctgtgac 540 attgcaccct ggatcaccct ggcttgtacc agcacacagg ccgtggaact cgtggccttt 600 gtgattgctt ttgtggtcat cctgagttca tgcctcatca ccttggtctc ctacatctat 660 atcatcagca caattctcag gatcccttcg gccagcagca ggagcaaagc cttctccaca 720 tgctcttcac atctcactgt ggtgctcatc tggtatgggt ccaccatctt tcttcatgtc 780 cgcctctcca tcaaagagtc cttggacctg accaaagcca ttcatgtcct gaacactgtg 840 gtgactccag ttctaaatcc cttcatctac actctccgta ataaagaagt aagggaaact 900 ctgctgaaga agtggaaggg gaattaa 927

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069269_0225_SL.TXT <210> 174 <211> 308 <212> PRT <213> Canis familiaris <400> 174

Met 1 Gly Thr Asp Asn 5 Ala Thr Arg His Gln Asp Phe Leu Leu Leu Gly 10 15 Phe Pro Gly Ser Gln Val Leu Gln Leu Ser Leu Phe Met Leu Phe Leu 20 25 30 Val Met Tyr Ile Leu Thr Val Gly Gly Asn Met Ala Ile Leu Met Leu 35 40 45 Val Ser Thr Ser His Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Ala Val Pro Lys 65 70 75 80 Ala Leu Ala Ile Leu Leu Gly Arg Ser Gln Thr Ile Thr Phe Thr Gly 85 90 95 Cys Leu Leu Gln Met Tyr Leu Val Phe Ser Leu Gly Cys Thr Glu Tyr 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Tyr 115 120 125 Pro Leu His Tyr Gly Ala Ile Met Asn Ser Leu Leu Ser Ala Gln Leu 130 135 140 Ala Leu Gly Ser Trp Leu Cys Gly Phe Leu Ala Ile Ser Val Pro Thr 145 150 155 160 Ala Leu Ile Ser Thr Leu Ser Phe Cys Gly Ser Arg Thr Ile Asn His 165 170 175

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Phe Phe Cys Asp Ile Ala Pro Trp Ile Thr Leu Ala Cys Thr Ser Thr 180 185 190 Gln Ala Val Glu Leu Val Ala Phe Val Ile Ala Phe Val Val Ile Leu 195 200 205 Ser Ser Cys Leu Ile Thr Leu Val Ser Tyr Ile Tyr Ile Ile Ser Thr 210 215 220 Ile Leu Arg Ile Pro Ser Ala Ser Ser Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Leu Ile Trp Tyr Gly Ser Thr Ile 245 250 255 Phe Leu His Val Arg Leu Ser Ile Lys Glu Ser Leu Asp Leu Thr Lys 260 265 270 Ala Ile His Val Leu Asn Thr Val Val Thr Pro Val Leu Asn Pro Phe 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Glu Val Arg Glu Thr Leu Leu Lys Lys 290 295 300 Trp Lys Gly Asn

305 <210> 175 <211> 945 <212> DNA <213> Canis familiaris <400> 175

atgggtggga ccaatgagag cactcaggga aatttcatcc ttctggggtt ttctgatcgc 60 ccctacctgg agaggatcct gtttgtggtc attctcattg catatctcct gacccttgtg 120 ggcaacacca ccatcatctt ggtgtcccgg ctggaccccc acctccacac tcccatgtac 180 ttctttctca ctcacctatc gttcctggac ctcggtttca ccaccagctc catccctcag 240 ttgttgtata acctgaatgg acatgacaag accatcagct acacaggctg tgccattcag 300

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ctcttcctat ttctgggttt gggtggtgtg gagtgcctac tcctggctgt catggcatat 360 gaccggtttg ttgcagtctg caaacccctc cactacatgg tgatcatgaa tccgcgcctc 420 tgcgtgggct tggtgtcagt ggcctggagc tgtggggtgg ccaactcctt ggccatgtcc 480 ccagtcactc tgcacttacc ccgctgtggg catcgcagtg tggaccactt cctgtgtgaa 540 gtgcctgccc tgatccggat ggcttgtgtc aatacagctg ccatcgaggg cactatcttt 600 gtcctggcag tgggcattgt gctttccccc ctggtgttca ttctggtgtc ttacagctat 660 attatgagag ctgtgttaca cattcagtca gtatcaggaa gacagaaggc cttcaacacc 720 tgtggctccc atctcacagt ggtctctctt ttctatggaa acatcatcta catgtacatg 780 caaccaggaa acagctcttc ccaggaccag ggaaagttcc tcactctctt ctacaacatt 840 gtcacaccac ttctgaaccc cctgatctac accctcagaa acaaggaagt gaaggtggct 900 ctgcagaggc tcctgctggg taaaagagag gtggggaagt gttga 945

<210> 176 <211> 314 <212> PRT <213> Canis familiaris <400> 176

Met Gly Gly Thr Asn Glu Ser Thr Gln Gly Asn Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asp Arg Pro Tyr Leu Glu Arg Ile Leu Phe Val Val Ile Leu 20 25 30 Ile Ala Tyr Leu Leu Thr Leu Val Gly Asn Thr Thr Ile Ile Leu Val 35 40 45 Ser Arg Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 His Leu Ser Phe Leu Asp Leu Gly Phe Thr Thr Ser Ser Ile Pro Gln 65 70 75 80 Leu Leu Tyr Asn Leu Asn Gly His Asp Lys Thr Ile Ser Tyr Thr Gly 85 90 95

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Cys Ala Ile Gln 100 Leu Phe Leu Phe Leu Gly Leu Gly Gly Val Glu Cys 105 110 Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Met Val Ile Met Asn Pro Arg Leu Cys Val Gly Leu 130 135 140 Val Ser Val Ala Trp Ser Cys Gly Val Ala Asn Ser Leu Ala Met Ser 145 150 155 160 Pro Val Thr Leu His Leu Pro Arg Cys Gly His Arg Ser Val Asp His 165 170 175 Phe Leu Cys Glu Val Pro Ala Leu Ile Arg Met Ala Cys Val Asn Thr 180 185 190 Ala Ala Ile Glu Gly Thr Ile Phe Val Leu Ala Val Gly Ile Val Leu 195 200 205 Ser Pro Leu Val Phe Ile Leu Val Ser Tyr Ser Tyr Ile Met Arg Ala 210 215 220 Val Leu His Ile Gln Ser Val Ser Gly Arg Gln Lys Ala Phe Asn Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Asn Ile Ile 245 250 255 Tyr Met Tyr Met Gln Pro Gly Asn Ser Ser Ser Gln Asp Gln Gly Lys 260 265 270 Phe Leu Thr Leu Phe Tyr Asn Ile Val Thr Pro Leu Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Val Ala Leu Gln Arg Leu 290 295 300

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Leu Leu Gly Lys Arg Glu Val Gly Lys Cys 305 310 <210> 177 <211> 972 <212> DNA <213> Canis familiaris <400> 177

atgaagcccc caaatgtgtc cagtgtcact gagtttcagc tcctggggtt ccagaacctt 60 cttgaatggc agacgctgct ctttcccatt ttcttgttca tctactttct cacagtcaca 120 gggaatgttg tcattattgc agtggtgagc gaggaccagc aactacactc acccatgtac 180 gtatttctca aacatctctc ctttctggag atctggtata catccaccat tgtgcccctt 240 ctcctagcca acctactctg ccatggccaa gccatctcct tccctgcgtg tatgatgcag 300 ctttacttct ttgtgttctt tggggctacc gaatgctttc ttctggctat gatggcctat 360 gaccgatatc tggccatctg caacccactc cactactctt tcctgatgag tcctgaaatc 420 tgcaccaagt tggtggcaat ctcctggttg acaggtgttg gaacaggatt tctgccctcg 480 ctaatgattt ccaagttgga tttctgtggt cctaacgaga tcaatcattt cttctgtgac 540 ctcccacccc tcatgcagct ctcatgttcc agtgtgttta tcaccaggat ggtcatcttt 600 atcctgtcaa ttgcagtgct gtgcatttgc ttttttctta ctctcatatc ctatgttttc 660 attgtatcta ccatattgag aattccttca gcctctggcc agatgaagac cttttccaca 720 tgtggctccc atttggctgt tgtcactatc tactatggga ccatgatctc catgtatgtt 780 cgccccaatg accacttatc acctgaaatt agtaagatca tttctgtctt ctacactgtg 840 gtcaccccat tgctgaaccc tgtcatctac agcttgagga accaagaatt caaagacgct 900 gttagaagag tcataagaaa aaagtgtggt atctatggag taagattgaa ggggagtttc 960 tgtgttaggt aa 972

<210> 178 <211> 323 <212> PRT <213> Canis familiaris <400> 178

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Met 1 Lys Pro Pro Asn Val Ser Ser Val Thr Glu Phe Gln Leu Leu Gly 5 10 15 Phe Gln Asn Leu Leu Glu Trp Gln Thr Leu Leu Phe Pro Ile Phe Leu 20 25 30 Phe Ile Tyr Phe Leu Thr Val Thr Gly Asn Val Val Ile Ile Ala Val 35 40 45 Val Ser Glu Asp Gln Gln Leu His Ser Pro Met Tyr Val Phe Leu Lys 50 55 60 His Leu Ser Phe Leu Glu Ile Trp Tyr Thr Ser Thr Ile Val Pro Leu 65 70 75 80 Leu Leu Ala Asn Leu Leu Cys His Gly Gln Ala Ile Ser Phe Pro Ala 85 90 95 Cys Met Met Gln Leu Tyr Phe Phe Val Phe Phe Gly Ala Thr Glu Cys 100 105 110 Phe Leu Leu Ala Met Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Asn 115 120 125 Pro Leu His Tyr Ser Phe Leu Met Ser Pro Glu Ile Cys Thr Lys Leu 130 135 140 Val Ala Ile Ser Trp Leu Thr Gly Val Gly Thr Gly Phe Leu Pro Ser 145 150 155 160 Leu Met Ile Ser Lys Leu Asp Phe Cys Gly Pro Asn Glu Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Pro Pro Leu Met Gln Leu Ser Cys Ser Ser Val 180 185 190 Phe Ile Thr Arg Met Val Ile Phe Ile Leu Ser Ile Ala Val Leu Cys 195 200 205

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Ile Cys Phe Phe Leu Thr Leu Ile 215 Ser Tyr Val Phe Ile Val Ser Thr 220 210 Ile Leu Arg Ile Pro Ser Ala Ser Gly Gln Met Lys Thr Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ala Val Val Thr Ile Tyr Tyr Gly Thr Met Ile 245 250 255 Ser Met Tyr Val Arg Pro Asn Asp His Leu Ser Pro Glu Ile Ser Lys 260 265 270 Ile Ile Ser Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Val 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Phe Lys Asp Ala Val Arg Arg Val 290 295 300 Ile Arg Lys Lys Cys Gly Ile Tyr Gly Val Arg Leu Lys Gly Ser Phe 305 310 315 320

Cys Val Arg <210> 179 <211> 708 <212> DNA <213> Canis familiaris <400> 179

acaatcatga cagaattcat ccttcttggt tttcacatga aaatcttgat cttattgaca 60 ttcctgatta tgtatgtgct gacagtttta agtaattcta caatcatcct actggtgtgg 120 aattgtaatc accttcactc atccacgtat ttgttccttg cacacctctc ctttctaaaa 180 atcatggtca cttctgtgac acctaaaatg ttggccgcta caatttcaca aatgaatacc 240 atatcatgta tcacccaata tttcttttat tttctcttta ggactgtaga gttcttcatt 300 ctggcaatta tgtcatatga tggctatgtt gccatctgta ttcctctgag ataccccatc 360 atcatgagaa ctcaggtctg cctaaagatg ataatggcct cttgggtgag agggttaatc 420

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069269_0225_SL.TXT tatatattat cgccttctgc tgtaacccta aaatttccat tctgtggtcc caatgtcaca gaccactttt tctgtgacac ttctcccatg ttgaaactgg tgtttggtga tctctgcatg gtggagatga ttcattttat ctgttctgca gttccccttc tgacctctct tttctttatt ctgactcctc atatcttcat tgtgtttacc atcgtcagaa tgccctctac ccagggacag tggaaagctt tctccacttg tgcttctcac attattgttg tcactatt

480

540

600

660

708 <210> 180 <211> 236 <212> PRT <213> Canis familiaris <400> 180

Thr Ile Met Thr 1 Glu 5 Phe Ile Leu Leu Gly Phe His Met 10 Lys Ile 15 Leu Ile Leu Leu Thr Phe Leu Ile Met Tyr Val Leu Thr Val Leu Ser Asn 20 25 30 Ser Thr Ile Ile Leu Leu Val Trp Asn Cys Asn His Leu His Ser Ser 35 40 45 Thr Tyr Leu Phe Leu Ala His Leu Ser Phe Leu Lys Ile Met Val Thr 50 55 60 Ser Val Thr Pro Lys Met Leu Ala Ala Thr Ile Ser Gln Met Asn Thr 65 70 75 80 Ile Ser Cys Ile Thr Gln Tyr Phe Phe Tyr Phe Leu Phe Arg Thr Val 85 90 95 Glu Phe Phe Ile Leu Ala Ile Met Ser Tyr Asp Gly Tyr Val Ala Ile 100 105 110 Cys Ile Pro Leu Arg Tyr Pro Ile Ile Met Arg Thr Gln Val Cys Leu 115 120 125 Lys Met Ile Met Ala Ser Trp Val Arg Gly Leu Ile Tyr Ile Leu Ser 130 135 140

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Pro 145 Ser Ala Val Thr Leu Lys Phe Pro Phe Cys Gly Pro Asn Val Thr 150 155 160 Asp His Phe Phe Cys Asp Thr Ser Pro Met Leu Lys Leu Val Phe Gly 165 170 175 Asp Leu Cys Met Val Glu Met Ile His Phe Ile Cys Ser Ala Val Pro 180 185 190 Leu Leu Thr Ser Leu Phe Phe Ile Leu Thr Pro His Ile Phe Ile Val 195 200 205 Phe Thr Ile Val Arg Met Pro Ser Thr Gln Gly Gln Trp Lys Ala Phe 210 215 220 Ser Thr Cys Ala Ser His Ile Ile Val Val Thr Ile 225 230 235

<210> 181 <211> 720 <212> DNA <213> Canis familiaris <400> 181

ttcagaatga gaaagaaata gaaattcctc tttttttctg cattcctgct catgtacatg 60 acatttctga ttggcaacac catgatcatc cttttggtgt gtggtgacta ccatctgcat 120 tcactcatgt atttctttgt ggccaatctt tctttccttg aagttgccat cacctccaca 180 gtggtaccta agatgctagc taacacattt cccctcacca aggcaatatc ctttatgggg 240 tatctcacac aatctttttt ctatttcctt ctggaatcca cagagttctt catcctggct 300 gtcatgtcat ttgattgatc tattgccatc tacaacccac tgaggtatgc cgtaatcatg 360 aacaaacaga catgcataat gttacttctg ggatcctatg taggtgcatt tttgtcaatt 420 ttagcatcat ccatcttaac tgctcctctg ctcttttgtg ggccaaatat aatcaatcac 480 tttttttgtg acagtggccc tgtgctaaag ctggtctgtg cagatatctc tctggctgaa 540 ttggctgatt ttatatcctc tgctgtgttg ctcttgggct ccctgctcct gacaggagtg 600 tcttacatgt acattatcat tacaatcctt agaattccct ctgtccaggg acgactgaag 660

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069269_0225_SL.TXT gctttctcca cctgtgtttc acacatcact gtagtgacac tgtattctgg aagttccatc

720 <210> 182 <211> 121 <212> PRT <213> Canis familiaris <400> 182

Met Asn 1 Lys Gln Thr Cys 5 Ile Met Leu Leu Leu Gly Ser Tyr Val Gly 10 15 Ala Phe Leu Ser Ile Leu Ala Ser Ser Ile Leu Thr Ala Pro Leu Leu 20 25 30 Phe Cys Gly Pro Asn Ile Ile Asn His Phe Phe Cys Asp Ser Gly Pro 35 40 45 Val Leu Lys Leu Val Cys Ala Asp Ile Ser Leu Ala Glu Leu Ala Asp 50 55 60 Phe Ile Ser Ser Ala Val Leu Leu Leu Gly Ser Leu Leu Leu Thr Gly 65 70 75 80 Val Ser Tyr Met Tyr Ile Ile Ile Thr Ile Leu Arg Ile Pro Ser Val 85 90 95 Gln Gly Arg Leu Lys Ala Phe Ser Thr Cys Val Ser His Ile Thr Val 100 105 110 Val Thr Leu Tyr Ser Gly Ser Ser Ile 115 120

<210> 183 <211> 828 <212> DNA <213> Canis familiaris <400> 183 agaaacaaga ctagagtcac tgaagtcatt cttctgggat ttcagaatga gaaagaaata gaaattcctt tttctgcatt cctgctcatg tacatgacat ctctgattgg caacaccatg

120

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atcatccttt tggtgtgtgg tgattactgt ctgcattcaa ccatgtattt ctttgtggcc 180 aatctttctt tccttgaact tgccatcact tccacagtgg tacctaagat gctagctaac 240 acatttcccc tcaccaaggc aatatccttt gtgggatgtc ttacacaatc tatcttctac 300 tttcttatgg gatccacaga gttcttcatc ctggctgtca tgttatttga tcaatctatt 360 gccatctgca acccactgag gtatgccatc atcatgaaca aatagacatg cataatgtta 420 cttctgggat cctatgttgg tgcatttttg tcaatgttgg tgccatctat cttaactgct 480 ccattagtct tttgtgggcc aaataaaatc catcattttt tctgtgacag aggccctatg 540 ctatagctgg cctgtacagg tatctctctg gctgaattgg ctgactttat ctcctctgct 600 gtgttgctct aaggctccct gctcctgacg gagtgtctta cacttatatt gttatcacta 660 tcctttagaa ttccttttgt ctagggatgg cagaaagcct tctctacttc tgtttcacat 720 atcacagtgg tcacacttta ttatgggagc tccgtcttcc tctatgttca tccaaagaaa 780 ggcagtgcac taaatattaa caaatttgcc acagtgctga acaccatt 828 <210> 184 <211> 134 <212> PRT <213> Canis familiaris <400> 184 Arg Asn Lys Thr Arg Val Thr Glu Val Ile Leu Leu Gly Phe Gln Asn 1 5 10 15 Glu Lys Glu Ile Glu Ile Pro Phe Ser Ala Phe Leu Leu Met Tyr Met 20 25 30 Thr Ser Leu i Ile Gly Asn Thr Met Ile Ile Leu Leu Val Cys Gly Asp 35 40 45 Tyr Cys Leu His Ser Thr Met Tyr Phe Phe Val Ala Asn Leu Ser Phe 50 55 60 Leu Glu Leu Ala Ile Thr Ser Thr Val Val Pro Lys Met Leu Ala Asn 65 70 75 80 Thr Phe Pro Leu Thr Lys Ala Ile Ser Phe Val Gly Cys Leu Thr Gln

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Ser Ile Phe Tyr Phe Leu Met Gly Ser Thr Glu Phe Phe Ile Leu Ala 100 105 110

Val Met Leu Phe Asp Gln Ser Ile Ala Ile Cys Asn Pro Leu Arg Tyr 115 120 125

Ala Ile Ile Met Asn Lys 130 <210> 185 <211> 936 <212> DNA <213> Canis familiaris <400> 185

atggtgggtg gaaatgaatc ctcagtaact gacttcatcc ttgtgggact ctttcctgaa 60 tttcagcatt ctattgttct caaccttgtg atcatcttca tctacatctt tgccttcctg 120 ggaaacatac ttctgattgt cttgatttgg ggagactctc agcttcatac gcccatgtac 180 attctcctca gtcaactctc cctcattgac ttgacattaa cttccaccat tgttccaaag 240 atggcttcta attttttcac aggggaaagg acaatatcat ggattggttg tggaacacag 300 agtttcttct tcctgatgtt gggaatgtca gagtgcctta ttttgactct catggcttat 360 gaccgctatg tggctgtctg caacccattg cgctatccca ttatcatgag ccctcgggtc 420 tgtatgcaca tgatttttgg gtgttggatt ggaggctctg taagttcatt tatccataca 480 gtctacccta tgcattttcc catctgtgga tcacgggaga tccaccacta cttctgtgag 540 gtcccagtcc taattaagct ctcctgtgaa gacacttcat tgtatcagtt ggtggtggtt 600 gtgacaagca ttgtgttgct tgttgtacct ttcagtctca tcactgtttc ctatactctc 660 atcttcctca ctgtctttcg tatgaactct gtcaaaggca ggaaaaaaac tctggccacc 720 tgctcttccc atctaactgt ggtgagtctc ttctttggcc caaacatatt tatctatatg 780 tctttcactt cctcccacag tgcggagcag gaccaagctc tttctgtatt cagcaatatt 840 ctaacaccca tgttgaaccc tctcatttac agcctgagga acaaagaggt ggtggcagct 900 ctcaggaagc ttatggggaa atgtgtgaca tcttag 936

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069269_0225_SL.TXT <210> 186 <211> 311 <212> PRT <213> Canis familiaris <400> 186

Met 1 Val Gly Gly Asn 5 Glu Ser Ser Val Thr Asp Phe Ile Leu Val Gly 10 15 Leu Phe Pro Glu Phe Gln His Ser Ile Val Leu Asn Leu Val Ile Ile 20 25 30 Phe Ile Tyr Ile Phe Ala Phe Leu Gly Asn Ile Leu Leu Ile Val Leu 35 40 45 Ile Trp Gly Asp Ser Gln Leu His Thr Pro Met Tyr Ile Leu Leu Ser 50 55 60 Gln Leu Ser Leu Ile Asp Leu Thr Leu Thr Ser Thr Ile Val Pro Lys 65 70 75 80 Met Ala Ser Asn Phe Phe Thr Gly Glu Arg Thr Ile Ser Trp Ile Gly 85 90 95 Cys Gly Thr Gln Ser Phe Phe Phe Leu Met Leu Gly Met Ser Glu Cys 100 105 110 Leu Ile Leu Thr Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Ile Ile Met Ser Pro Arg Val Cys Met His Met 130 135 140 Ile Phe Gly Cys Trp Ile Gly Gly Ser Val Ser Ser Phe Ile His Thr 145 150 155 160 Val Tyr Pro Met His Phe Pro Ile Cys Gly Ser Arg Glu Ile His His 165 170 175

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Tyr Phe Cys Glu Val Pro Val Leu Ile Lys Leu Ser Cys Glu 190 Asp Thr 180 185 Ser Leu Tyr Gln Leu Val Val Val Val Thr Ser Ile Val Leu Leu Val 195 200 205 Val Pro Phe Ser Leu Ile Thr Val Ser Tyr Thr Leu Ile Phe Leu Thr 210 215 220 Val Phe Arg Met Asn Ser Val Lys Gly Arg Lys Lys Thr Leu Ala Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Ser Leu Phe Phe Gly Pro Asn Ile 245 250 255 Phe Ile Tyr Met Ser Phe Thr Ser Ser His Ser Ala Glu Gln Asp Gln 260 265 270 Ala Leu Ser Val Phe Ser Asn Ile Leu Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Val Ala Ala Leu Arg Lys Leu 290 295 300 Met Gly Lys Cys Val Thr Ser

305 310 <210> 187 <211> 939 <212> DNA <213> Canis familiaris <400> 187 atgagaagta ggaatgaaac agaatccaca gacttcattc tcctgggctt cttccctgaa tttaaacaca tcacagccgt ggtctccatc attcttctga tctacatggc cgccttcact ggcaacactc ttctgatcat cctcatttgg ttgtattccc atctccacac ccccatgtac ttcctgctca gtcagctctc cttaatggac ttgactttga cctctagcat tgtccccaag atggtggcca acttcttctc tggttggcgg aacatatcat tcctggcttg tgggactcaa

120

180

240

300

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attttcttct ccctgactgt ggccattgca gaatgcatcc ttataactct catgtgcttt 360 gatcgttacg tggctatatg tgatcctctg cggtacccag ttatcatcaa tcctagagtt 420 tgcttacgga tgattgccat gtcttgggct ggaggggcac ttacttctct gggtcacact 480 gtttttacct tacattttaa tatctgcaac cctagagaga ttccccactt cttctgcgaa 540 gtcatggctg tgcttaggat cgtctgtgag gatatctcag cctatgagaa ggcagtggtg 600 ataacaagca tccttgttct gcttctgcca ttatctctca ttttgtcttc ctatgttctc 660 atactccttg ctgtactccg aatgaactcc ccagagggca ggaacaaggc tctagccacc 720 tgctcctctc acctctgtgt ggtgggtctc tattttggtc caggtatgtg catctacatg 780 agacctggtt ctgccaagac tccaaagttg aatcagggtc tctttctatt tggaactgtc 840 ctcactccac tcctaaaccc tcttgcctat agtctcagga acaaggatgt tctaagtgca 900 ctgaaaaagt taatggggag gtatcagtcc tcaaagtaa 939

<210> 188 <211> 312 <212> PRT <213> Canis familiaris <400> 188

Met Arg Ser Arg Asn Glu Thr Glu Ser Thr Asp Phe Ile Leu Leu Gly 1 5 10 15 Phe Phe Pro Glu Phe Lys His Ile Thr Ala Val Val Ser Ile Ile Leu 20 25 30 Leu Ile Tyr Met Ala Ala Phe Thr Gly Asn Thr Leu Leu Ile Ile Leu 35 40 45 Ile Trp Leu Tyr Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Met Asp Leu Thr Leu Thr Ser Ser Ile Val Pro Lys 65 70 75 80 Met Val Ala Asn Phe Phe Ser Gly Trp Arg Asn Ile Ser Phe Leu Ala 85 90 95

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Cys Gly Thr Gln 100 Ile Phe Phe Ser Leu Thr Val Ala Ile Ala Glu Cys 105 110 Ile Leu Ile Thr Leu Met Cys Phe Asp Arg Tyr Val Ala Ile Cys Asp 115 120 125 Pro Leu Arg Tyr Pro Val Ile Ile Asn Pro Arg Val Cys Leu Arg Met 130 135 140 Ile Ala Met Ser Trp Ala Gly Gly Ala Leu Thr Ser Leu Gly His Thr 145 150 155 160 Val Phe Thr Leu His Phe Asn Ile Cys Asn Pro Arg Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Val Met Ala Val Leu Arg Ile Val Cys Glu Asp Ile 180 185 190 Ser Ala Tyr Glu Lys Ala Val Val Ile Thr Ser Ile Leu Val Leu Leu 195 200 205 Leu Pro Leu Ser Leu Ile Leu Ser Ser Tyr Val Leu Ile Leu Leu Ala 210 215 220 Val Leu Arg Met Asn Ser Pro Glu Gly Arg Asn Lys Ala Leu Ala Thr 225 230 235 240 Cys Ser Ser His Leu Cys Val Val Gly Leu Tyr Phe Gly Pro Gly Met 245 250 255 Cys Ile Tyr Met Arg Pro Gly Ser Ala Lys Thr Pro Lys Leu Asn Gln 260 265 270 Gly Leu Phe Leu Phe Gly Thr Val Leu Thr Pro Leu Leu Asn Pro Leu 275 280 285 Ala Tyr Ser Leu Arg Asn Lys Asp Val Leu Ser Ala Leu Lys Lys Leu 290 295 300

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Met Gly Arg Tyr Gln Ser Ser Lys 305 310 <210> 189 <211> 969 <212> DNA <213> Canis familiaris <400> 189

atggagagaa acaataagac catcaccaca gattttatcc tcttggggct ctggcctgag 60 tttagccacc ttgcggtcct tatctgcttc attcttatgg tttaccttat ggctgtaatg 120 ggcaatgctg ttctcattct cctcatctgg ttggattctc gactccactc tcctatgtac 180 ttcttgctca gccagctctc ccttattgat gtggccttga tctcaactac agtccccaaa 240 atggtcacca acttcttctc agggaaaagg accatatcac agattggctg tggagctcag 300 attttattca gcttaacctt gggaatttct gagtgccttc tactgactct catgtcctat 360 gaccgctaca ttgccatctg caatccacta cgttactcaa tcttgatgag ccataccacc 420 tgtaaacaga tggttgttgg gtcctgggca ggaggggcaa taacttccct ggttcataca 480 gcctatgtca tgcacttagc catctgtcat cctcgagaga tcccacactt cttgtgtgag 540 gtcatggcac tccttaagct cacttgtgag gacatttcag cctatgtgaa gtcagtggtg 600 gtctcaagct ttctggtggt cctcatccct ctgagtctca tcctggcttc ctacatccac 660 atatttcttg ctgtcctccg catgaactcc cttgaaggta aaaacaaggc cttggccaca 720 tgcttctccc acctctgtgt ggtcagtctc tactttggcc ctgccatatt agtctatatg 780 aggccaggat cctttaaaac tcccaaaata aaccagtccc tttttatgtt taatgccatt 840 cttactccta tgcttaatcc cctcatctat agcctgagaa acaaggatgt catagcagct 900 ctgaagagta taatcatcag tagaatcctc ctaaaaaaga tgaaaagaca gctaggttgc 960

catacataa 969 <210> 190 <211> 322 <212> PRT <213> Canis familiaris <400> 190

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Met 1 Glu Arg Asn Asn 5 Lys Thr Ile Thr Thr Asp Phe Ile Leu Leu Gly 10 15 Leu Trp Pro Glu Phe Ser His Leu Ala Val Leu Ile Cys Phe Ile Leu 20 25 30 Met Val Tyr Leu Met Ala Val Met Gly Asn Ala Val Leu Ile Leu Leu 35 40 45 Ile Trp Leu Asp Ser Arg Leu His Ser Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Ile Asp Val Ala Leu Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Val Thr Asn Phe Phe Ser Gly Lys Arg Thr Ile Ser Gln Ile Gly 85 90 95 Cys Gly Ala Gln Ile Leu Phe Ser Leu Thr Leu Gly Ile Ser Glu Cys 100 105 110 Leu Leu Leu Thr Leu Met Ser Tyr Asp Arg Tyr Ile Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Ser Ile Leu Met Ser His Thr Thr Cys Lys Gln Met 130 135 140 Val Val Gly Ser Trp Ala Gly Gly Ala Ile Thr Ser Leu Val His Thr 145 150 155 160 Ala Tyr Val Met His Leu Ala Ile Cys His Pro Arg Glu Ile Pro His 165 170 175 Phe Leu Cys Glu Val Met Ala Leu Leu Lys Leu Thr Cys Glu Asp Ile 180 185 190 Ser Ala Tyr Val Lys Ser Val Val Val Ser Ser Phe Leu Val Val Leu 195 200 205

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Ile Pro 210 Leu Ser Leu Ile Leu 215 069269_0225_SL.TXT Ala Ser Tyr Ile His Ile 220 Phe Leu Ala Val Leu Arg Met Asn Ser Leu Glu Gly Lys Asn Lys Ala Leu Ala Thr 225 230 235 240 Cys Phe Ser His Leu Cys Val Val Ser Leu Tyr Phe Gly Pro Ala Ile 245 250 255 Leu Val Tyr Met Arg Pro Gly Ser Phe Lys Thr Pro Lys Ile Asn Gln 260 265 270 Ser Leu Phe Met Phe Asn Ala Ile Leu Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Ile Ala Ala Leu Lys Ser Ile 290 295 300 Ile Ile Ser Arg Ile Leu Leu Lys Lys Met Lys Arg Gln Leu Gly Cys 305 310 315 320

His Thr <210> 191 <211> 960 <212> DNA <213> Canis familiaris <400> 191

atggagatac gaaatgagac attgagcaca gacttcattc tcctgggcct tttctctgga 60 atgaaacata ccagacttct tgtctctgtt gtcctcctca tctacaccat tgctatcaca 120 ggaaacacca ctttgatctt ccttatctgg gtggatcccc atctccacac ctccatgtat 180 ttcctgctta gccaactctc tctcattgac ctggctttca tctctagcat agtcccaaaa 240 atgatggtta attttttctc aggaaagaag aatatttccc tggttggctg tgggacccag 300 atcttcttca ctttgactct ggggattgct gagtgcctac tcttgaccct catggcttat 360 gaccgctatg tggccatctg caatcctctc aagtactcaa ttattatcag ccctcgggtc 420

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tcccagagaa tggccattgg gtcctgggtg ggagggactc tagcatccct ggcccacaca 480 gcctatgcca tgcattttcc cctctgtggc ccccgggaac tccacaactt cttctgtgag 540 gtcaaagcca ttttgaagct gtcttgtgag gacatctcag cctatgagaa aggagtagta 600 gtgactagta ttgtggtggt tcttctccca gtaagcttca tcttgacctc ctatatcctc 660 atcttccttc aggtcctgcg aataaactcc catgagggaa ggataaaggc tctggctacc 720 tgttcttccc atctgactgt ggtcatcttt tactatggtc cagccatgct aatatatatg 780 aggcctggat cttcccacac ccccattctg aaccaggctc tctttatgtt tgacaccgtc 840 cttactccca tgctgaaccc tatcatctac agtctaagga acagggaggt tgtagactca 900 atgaagaagg taatggggaa gttttccatt caaaataggt ttgcacgttt caatgaatag 960

<210> 192 <211> 319 <212> PRT <213> Canis familiaris <400> 192

Met Glu Ile Arg Asn Glu Thr Leu Ser Thr Asp Phe Ile Leu Leu Gly 1 5 10 15 Leu Phe Ser Gly Met Lys His Thr Arg Leu Leu Val Ser Val Val Leu 20 25 30 Leu Ile Tyr Thr Ile Ala Ile Thr Gly Asn Thr Thr Leu Ile Phe Leu 35 40 45 Ile Trp Val Asp Pro His Leu His Thr Ser Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Ile Asp Leu Ala Phe Ile Ser Ser Ile Val Pro Lys 65 70 75 80 Met Met Val Asn Phe Phe Ser Gly Lys Lys Asn Ile Ser Leu Val Gly 85 90 95 Cys Gly Thr Gln Ile Phe Phe Thr Leu Thr Leu Gly Ile Ala Glu Cys 100 105 110

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Leu Leu Leu 115 Thr Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 120 125 Pro Leu Lys Tyr Ser Ile Ile Ile Ser Pro Arg Val Ser Gln Arg Met 130 135 140 Ala Ile Gly Ser Trp Val Gly Gly Thr Leu Ala Ser Leu Ala His Thr 145 150 155 160 Ala Tyr Ala Met His Phe Pro Leu Cys Gly Pro Arg Glu Leu His Asn 165 170 175 Phe Phe Cys Glu Val Lys Ala Ile Leu Lys Leu Ser Cys Glu Asp Ile 180 185 190 Ser Ala Tyr Glu Lys Gly Val Val Val Thr Ser Ile Val Val Val Leu 195 200 205 Leu Pro Val Ser Phe Ile Leu Thr Ser Tyr Ile Leu Ile Phe Leu Gln 210 215 220 Val Leu Arg Ile Asn Ser His Glu Gly Arg Ile Lys Ala Leu Ala Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Ile Phe Tyr Tyr Gly Pro Ala Met 245 250 255 Leu Ile Tyr Met Arg Pro Gly Ser Ser His Thr Pro Ile Leu Asn Gln 260 265 270 Ala Leu Phe Met Phe Asp Thr Val Leu Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Glu Val Val Asp Ser Met Lys Lys Val 290 295 300 Met Gly Lys Phe Ser Ile Gln Asn Arg Phe Ala Arg Phe Asn Glu 305 310 315

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069269_0225_SL.TXT <210> 193 <211> 819 <212> DNA <213> Canis familiaris <400> 193

gaccaaggaa atggatcctc caccacaggt ttcattcttg tgggattttt ctctgacttt 60 cggcatccta aactcctcat ctccattgtc catctgattc ctggggtggc catccacagg 120 atattccaac ctggcactgc tgatccaggg tgatgcttgc ctctacaccc ccatatactt 180 cctgctcaga cagctctttt tcatggacat aaagttagtc ctcaccactc tcatcaaatg 240 gccaccaact tctctggata tagatacatc tgtcacattg gctgtagagt ccaaaccttt 300 ctttctttga agataggagt atctgaatgt gttgtcctga gtcttatggc ctttgaccac 360 tatcacgcca tctgtagtgt gctcagatac ctggctatca tgacactctg aaactgtaag 420 caaatggcca ttggttcatg ggctatcagt atgctcatct ccttaatgta cacaaattat 480 ggcatgcact tctctgcttg tggccccagg aaaactgacc acttctgtga agttctcatt 540 cttctcatcc cttttgtact cattctgaca tcctacatac tcatttatct tactgttctc 600 tatgtaaatt tccctgagag caaaaacaaa gctctagcta cctgcttatc ccatcttggt 660 gtggtaagtc tctactttgg tccaaccatg cttatctaca tgactccagg tttctctctt 720 ctcccagagg tggaccagca tctctttgtg tctggtgtaa tcattatccc aatgcttaac 780 cccctcatct acagcctgag gaacaaggag atgttgggg 819

<210> 194 <211> 132 <212> PRT <213> Canis familiaris <400> 194

Met Ala Ile Gly Ser Trp Ala Ile Ser Met 10 Leu Ile Ser Leu Met 15 Tyr 1 5 Thr Asn Tyr Gly Met His Phe Ser Ala Cys Gly Pro Arg Lys Thr Asp 20 25 30 His Phe Cys Glu Val Leu Ile Leu Leu Ile Pro Phe Val Leu Ile Leu 35 40 45

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Thr Ser Tyr Ile 50 Leu Ile Tyr Leu Thr Val Leu Tyr Val Asn Phe Pro 55 60 Glu Ser Lys Asn Lys Ala Leu Ala Thr Cys Leu Ser His Leu Gly Val 65 70 75 80 Val Ser Leu Tyr Phe Gly Pro Thr Met Leu Ile Tyr Met Thr Pro Gly 85 90 95 Phe Ser Leu Leu Pro Glu Val Asp Gln His Leu Phe Val Ser Gly Val 100 105 110 Ile Ile Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys 115 120 125

Glu Met Leu Gly 130 <210> 195 <211> 924 <212> DNA <213> Canis familiaris <400> 195

atgaataaga gcattgtaac ggaatttttg attctgggct tcacccaaaa acctgaactg 60 caaagagctc tcttcattgt ctttctcctc atctaccttg tggccttact tggcaatgca 120 ctgattgtca ttgccataat ctgtaacacc accttgcata cacccatgta tgttttcctt 180 ctggcactgg ctattgtgga tatcatctgc acaacaagca ttatacccaa gatgctgggg 240 accatgctaa caacgggaag gagtatttcc tatgaaagct gcatgtcaca gctcttcttc 300 ttcacgtggt ccctgggggc cgagatggtt ctcttcacca caatggccta tgaccgctat 360 gtggccatct gtttccctct tcgctacaga actatgatga acccccatat gtgtgtggcc 420 ttgcttggca ttaccatggt gattgctgta accaattcct gggtacacac tggtcttatc 480 ctgaggctga ctttctgtgg gccaaatatc attgaccact tcttctgtga gatacctcca 540 cttctgtctt tgtcctgcag ccctgtgagg atcaatgagg tgatggtgta tgttgctgat 600

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attaccctgg ccataggtga cttcacgctc acctgcatct cctatggttt catcattgct 660 gccattctcc gcatccacac ggcagaaggc aagaggaagg ctttctcaac atgttcatcc 720 cacctcatag tggtgtccct ttactactct cctgtgatct acacctatat ccgccctgct 780 tctagctact catttgaaag ggacaaggtg ataactgcac tctatactct cgtgacccca 840 acattaaacc caattgtgta tagtttccga aataaggaga tgcagacagg gattcagaag 900 gtatttgcat ttctgagaca ttag 924

<210> 196 <211> 307 <212> PRT <213> Canis familiaris <400> 196

Met 1 Asn Lys Ser Ile 5 Val Thr Glu Phe Leu Ile Leu Gly Phe Thr Gln 10 15 Lys Pro Glu Leu Gln Arg Ala Leu Phe Ile Val Phe Leu Leu Ile Tyr 20 25 30 Leu Val Ala Leu Leu Gly Asn Ala Leu Ile Val Ile Ala Ile Ile Cys 35 40 45 Asn Thr Thr Leu His Thr Pro Met Tyr Val Phe Leu Leu Ala Leu Ala 50 55 60 Ile Val Asp Ile Ile Cys Thr Thr Ser Ile Ile Pro Lys Met Leu Gly 65 70 75 80 Thr Met Leu Thr Thr Gly Arg Ser Ile Ser Tyr Glu Ser Cys Met Ser 85 90 95 Gln Leu Phe Phe Phe Thr Trp Ser Leu Gly Ala Glu Met Val Leu Phe 100 105 110 Thr Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro Leu Arg 115 120 125 Tyr Arg Thr Met Met Asn Pro His Met Cys Val Ala Leu Leu Gly Ile

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130 135 140

Thr Met Val Ile 145 Ala Val Thr Asn Ser Trp Val His Thr Gly Leu Ile 150 155 160 Leu Arg Leu Thr Phe Cys Gly Pro Asn Ile Ile Asp His Phe Phe Cys 165 170 175 Glu Ile Pro Pro Leu Leu Ser Leu Ser Cys Ser Pro Val Arg Ile Asn 180 185 190 Glu Val Met Val Tyr Val Ala Asp Ile Thr Leu Ala Ile Gly Asp Phe 195 200 205 Thr Leu Thr Cys Ile Ser Tyr Gly Phe Ile Ile Ala Ala Ile Leu Arg 210 215 220 Ile His Thr Ala Glu Gly Lys Arg Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Leu Ile Val Val Ser Leu Tyr Tyr Ser Pro Val Ile Tyr Thr Tyr 245 250 255 Ile Arg Pro Ala Ser Ser Tyr Ser Phe Glu Arg Asp Lys Val Ile Thr 260 265 270 Ala Leu Tyr Thr Leu Val Thr Pro Thr Leu Asn Pro Ile Val Tyr Ser 275 280 285 Phe Arg Asn Lys Glu Met Gln Thr Gly Ile Gln Lys Val Phe Ala Phe

290 295 300

Leu Arg His 305 <210> 197 <211> 939 <212> DNA <213> Canis familiaris

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069269_0225_SL.TXT <400> 197 atggataaaa gaaatgagtc ttcaagtaca gattttatcc tcttgggcct ctttcctggt 60 ataaaacaca tcaacctcct tgtctctgtc atccttctga tctacactgt agctctcacc 120 acaaattcca tccttatact tctgatctgg gtggattctc acctccatac acccatgtac 180 tttctgctta gccaactggc tctcatggac ctgacattaa tctctagcac tgtacccaag 240 atggcaagtg acttcttctc agtgaagagg actatatcac aggtggcctg tggtactcag 300 atatttttct tcctgactgt aggaattgct gagtgtatta tcataaccct tatggccttt 360 gaccgttatg tggccatctg caaacctctg agatataccc tgatcatgag ccagaaagta 420 tgtctgcaaa tggctactgt ctcctgggct ggaggtgccc ttatatcact catgcacaca 480 gcatatgcta tgcatttccc catctgcggt tccagagaga tttcccattt cctctgcgag 540 gtcatggcta tcctaaaatt ggcctgtgag gacatctctg cctatgagaa ggctgtagta 600 atgacaagca ttgtggtgct cctcatccct ttgtccttta tcctgtcttc ttatactctc 660 atcttccttt ccgtcctccg catgaactcc ctggagggca ggaataaagc cctggccaca 720 tgttcttccc acctgactgt ggtgagcctc tactttggtc cagcgatgct ggtttacatg 780 aggcccagtt cttaccacag tcccaagctg gaccaggttc tctttatgct tggtgccatc 840 ctcaccccca tgatgaaccc ccttatatat agtctgagga acaaggaggt agtgggtgtt 900 ctgagaaaca tgttgggaag ctgcctaacc tcacattag 939 <210> 198 <211> 312 <212> PRT <213> Canis familiaris <400> 198

Met 1 Asp Lys Arg Asn Glu Ser Ser Ser Thr Asp Phe Ile Leu Leu Gly 5 10 15 Leu Phe Pro Gly Ile Lys His Ile Asn Leu Leu Val Ser Val Ile Leu 20 25 30 Leu Ile Tyr Thr Val Ala Leu Thr Thr Asn Ser Ile Leu Ile Leu Leu 35 40 45

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Ile Trp 50 Val Asp Ser His Leu 55 069269_0225_SL.TXT His Thr Pro Met Tyr Phe 60 Leu Leu Ser Gln Leu Ala Leu Met Asp Leu Thr Leu Ile Ser Ser Thr Val Pro Lys 65 70 75 80 Met Ala Ser Asp Phe Phe Ser Val Lys Arg Thr Ile Ser Gln Val Ala 85 90 95 Cys Gly Thr Gln Ile Phe Phe Phe Leu Thr Val Gly Ile Ala Glu Cys 100 105 110 Ile Ile Ile Thr Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Arg Tyr Thr Leu Ile Met Ser Gln Lys Val Cys Leu Gln Met 130 135 140 Ala Thr Val Ser Trp Ala Gly Gly Ala Leu Ile Ser Leu Met His Thr 145 150 155 160 Ala Tyr Ala Met His Phe Pro Ile Cys Gly Ser Arg Glu Ile Ser His 165 170 175 Phe Leu Cys Glu Val Met Ala Ile Leu Lys Leu Ala Cys Glu Asp Ile 180 185 190 Ser Ala Tyr Glu Lys Ala Val Val Met Thr Ser Ile Val Val Leu Leu 195 200 205 Ile Pro Leu Ser Phe Ile Leu Ser Ser Tyr Thr Leu Ile Phe Leu Ser 210 215 220 Val Leu Arg Met Asn Ser Leu Glu Gly Arg Asn Lys Ala Leu Ala Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Ser Leu Tyr Phe Gly Pro Ala Met 245 250 255

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Leu Val Tyr Met Arg Pro Ser Ser Tyr His Ser Pro Lys Leu 270 Asp Gln 260 265 Val Leu Phe Met Leu Gly Ala Ile Leu Thr Pro Met Met Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Val Gly Val Leu Arg Asn Met 290 295 300 Leu Gly Ser Cys Leu Thr Ser His 305 310

<210> 199 <211> 948 <212> DNA <213> Canis familiaris <400> 199

atgaaaatta tggaaaatta caaccaaaca ttaacagatt tccttttatt ggggttgttt 60 ccatcatcaa gaattggcct ctttcttttc attctcatag tatttatttt cttaatggct 120 ctttttggca acctgtccat gatcatcctc atcatcgtgg acactcatct ccacacaccc 180 atgtattttc tacttagcca gctctccctc atggacctaa actacatctc caccattgtc 240 ccaaagatgg tttctgatta tctctttgga aacaagtcca tctcacttat tggttgtgaa 300 gttcagagct tcttcttctt gactttagca gttgcagaag cactactctt gacatctatg 360 gcttatgatc gttacgtggc tatttgcttt cctcttcact atcccattcg catgagcaaa 420 aaattgtgtg tgctgatgat aacaggatct tggacaattg gctctatcaa ctcctgtgct 480 cacactgcat atgccttcca tataccttac tgtcgatcca gaactatcaa ccatttcttc 540 tgtgatgtcc cagccatgtt gacgttggcc tgcatggaca cctgggtcta tgagtacaca 600 gtgtttgtaa gcaccacact cttgattgtg tttcctttca ttggcattgc atgctcctat 660 ggccaggtcc tccttgccat ctgccgcatg caatcaacag aagggaggaa gaaagcttat 720 tccacctgca gcactcacct cactgtggtg actttctact atgcaccctt tgcttacact 780 tatctacgcc caagatccct ccgaacccca acagaggaca aggctctagc tgttctctac 840 accattctga ccccaatgct caaccccatc atctacagcc tgagaaacaa ggaggtgata 900

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948

069269_0225_SL.TXT ggggccctga gacgattgat tcagaagatc agctttgtaa aaatgtag <210> 200 <211> 315 <212> PRT <213> Canis familiaris <400> 200

Met 1 Lys Ile Met Glu 5 Asn Tyr Asn Gln Thr Leu Thr Asp Phe Leu Leu 10 15 Leu Gly Leu Phe Pro Ser Ser Arg Ile Gly Leu Phe Leu Phe Ile Leu 20 25 30 Ile Val Phe Ile Phe Leu Met Ala Leu Phe Gly Asn Leu Ser Met Ile 35 40 45 Ile Leu Ile Ile Val Asp Thr His Leu His Thr Pro Met Tyr Phe Leu 50 55 60 Leu Ser Gln Leu Ser Leu Met Asp Leu Asn Tyr Ile Ser Thr Ile Val 65 70 75 80 Pro Lys Met Val Ser Asp Tyr Leu Phe Gly Asn Lys Ser Ile Ser Leu 85 90 95 Ile Gly Cys Glu Val Gln Ser Phe Phe Phe Leu Thr Leu Ala Val Ala 100 105 110 Glu Ala Leu Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys Phe Pro Leu His Tyr Pro Ile Arg Met Ser Lys Lys Leu Cys Val 130 135 140 Leu Met Ile Thr Gly Ser Trp Thr Ile Gly Ser Ile Asn Ser Cys Ala 145 150 155 160 His Thr Ala Tyr Ala Phe His Ile Pro Tyr Cys Arg Ser Arg Thr Ile 165 170 175

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Asn His Phe Phe 180 Cys Asp Val Pro Ala Met 185 Leu Thr Leu Ala Cys Met 190 Asp Thr Trp Val Tyr Glu Tyr Thr Val Phe Val Ser Thr Thr Leu Leu 195 200 205 Ile Val Phe Pro Phe Ile Gly Ile Ala Cys Ser Tyr Gly Gln Val Leu 210 215 220 Leu Ala Ile Cys Arg Met Gln Ser Thr Glu Gly Arg Lys Lys Ala Tyr 225 230 235 240 Ser Thr Cys Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro 245 250 255 Phe Ala Tyr Thr Tyr Leu Arg Pro Arg Ser Leu Arg Thr Pro Thr Glu 260 265 270 Asp Lys Ala Leu Ala Val Leu Tyr Thr Ile Leu Thr Pro Met Leu Asn 275 280 285 Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Gly Ala Leu Arg 290 295 300 Arg Leu Ile Gln Lys Ile Ser Phe Val Lys Met 305 310 315

<210> 201 <211> 939 <212> DNA <213> Canis familiaris <400> 201 atggaaaata ataacccaaa ttctacagat ttcttcctat tggggttatt tccaccatca agaattggcc tgttcttctt cattctcatt gttttcattt tcttaatggc gctttttggc aacttgtgca tgatcatcct catcttccta gacacccatc tccacacacc catgtatttt ctacttagtc agctctccct catggacctg agctacatct ccaccattgt ccctgagatg gcttctaatt atctctctga aaacaagtct atttctttca ttggttgtgg ggttcagagc Page 219

120

180

240

300

069269_0225_SL.TXT

ttcttcttcc tgactttagc aggtggagaa ggattaatat tggcctcaat ggcctatgat 360 cgttatgtgg ctatttgctt tcctctccac tatgccattc gtatgagcaa aagagtgtgt 420 gtgctgatga taacaggatc ttggataatg ggctcaatca actcctgtgc ccacactgca 480 tatgccctca atatacctta ctgtcaatcc agagccatta accatttctt ctgtgatgtc 540 ccagccatgt tgacattggc ctgcatggac acctggatct atgagtacac agtgtttgta 600 agcaccacac tcttgattgt gtttcctttc attggcattg catgctccta tggccgggtc 660 ctccttgcca tttgccgcat gcaatcaaca gaagggagga agaaagccta ttccacctgc 720 agcactcacc tcactgtggt gactttctac tatgcaccct tcgcttacac ttatctacgc 780 ccgagatccc tccgaagtcc gacagaagac aaggctctag ctgtcttcta caccatccta 840 actccaatgc tcaatcccat catctacagc atgagaaata aggaggtaat gggggccttg 900 agacgactga ttcagaggat cagctctgaa aagatgtag 939

<210> 202 <211> 312 <212> PRT <213> Canis familiaris <400> 202

Met Glu Asn Asn Asn Pro Asn Ser Thr Asp Phe Phe Leu Leu Gly Leu 1 5 10 15 Phe Pro Pro Ser Arg Ile Gly Leu Phe Phe Phe Ile Leu Ile Val Phe 20 25 30 Ile Phe Leu Met Ala Leu Phe Gly Asn Leu Cys Met Ile Ile Leu Ile 35 40 45 Phe Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 50 55 60 Leu Ser Leu Met Asp Leu Ser Tyr Ile Ser Thr Ile Val Pro Glu Met 65 70 75 80 Ala Ser Asn Tyr Leu Ser Glu Asn Lys Ser Ile Ser Phe Ile Gly Cys 85 90 95

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Gly Val Gln Ser 100 Phe Phe Phe Leu Thr Leu Ala Gly Gly Glu Gly Leu 105 110 Ile Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro 115 120 125 Leu His Tyr Ala Ile Arg Met Ser Lys Arg Val Cys Val Leu Met Ile 130 135 140 Thr Gly Ser Trp Ile Met Gly Ser Ile Asn Ser Cys Ala His Thr Ala 145 150 155 160 Tyr Ala Leu Asn Ile Pro Tyr Cys Gln Ser Arg Ala Ile Asn His Phe 165 170 175 Phe Cys Asp Val Pro Ala Met Leu Thr Leu Ala Cys Met Asp Thr Trp 180 185 190 Ile Tyr Glu Tyr Thr Val Phe Val Ser Thr Thr Leu Leu Ile Val Phe 195 200 205 Pro Phe Ile Gly Ile Ala Cys Ser Tyr Gly Arg Val Leu Leu Ala Ile 210 215 220 Cys Arg Met Gln Ser Thr Glu Gly Arg Lys Lys Ala Tyr Ser Thr Cys 225 230 235 240 Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Ala Tyr 245 250 255 Thr Tyr Leu Arg Pro Arg Ser Leu Arg Ser Pro Thr Glu Asp Lys Ala 260 265 270 Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 275 280 285 Tyr Ser Met Arg Asn Lys Glu Val Met Gly Ala Leu Arg Arg Leu Ile 290 295 300

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Gln Arg Ile Ser Ser Glu Lys Met 305 310 <210> 203 <211> 852 <212> DNA <213> Canis familiaris <400> 203

atagatacat tcctctttgt tgccattgta atcctctttt ccatggctct gatggggaac 60 atcatactgg tccttctcat tcaggtggac accagactcc acactccaat gtactttcta 120 ctcagccagc tctcctttat cgatatcatg tacatctcca caacagtgcc caagatgacc 180 actaacttct tatcaaacag taaacataaa cagtaaacat tattaggctt tgagattcaa 240 acctttgtat tcttggccct tggtgggact gaagccctcc tccttggttt catgtcctat 300 gatagatatg catctatctg tcatccttta cattatcttg ttctcatgag caagaagacc 360 tgttggttca tgatcgcaag tgcatgggcc agtagttcta ccaaagtttt agtgcataca 420 ctgtatgtat ttcaactttg gttctgtagg ttttggatca ttaaccactt tttctgtgaa 480 attccataac ttttgccatt ggtctgtcag gatacttccc agtatgagtg tacaggcctc 540 ctcagtgtgc ttatcattct gctgctacca ttcatggcca ttctggcttc ctatgcctga 600 atacttacta ttgtgttcca gatgagctca ggtaaaggac agataaaagc tgtctccact 660 tgctcctctc acctgattgt ggcaagccta ttttatagaa ctactctctc cacctataca 720 aggcctcact ccatgcattc tccagaacag gataaggcag gggtggtgtt ttatgccatc 780 atcacacctc ttctgaaccc acttatctat agcctgagga ataaagaggt gatcagggcc 840 atagaaagaa tg 852

<210> 204 <211> 77 <212> PRT <213> Canis familiaris <400> 204

Met Ser Ser Gly Lys Gly Gln Ile Lys Ala Val Ser Thr Cys Ser Ser 1 5 10 15

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His Leu Ile Val Ala Ser Leu Phe Tyr Arg Thr Thr Leu Ser Thr Tyr 20 25 30 Thr Arg Pro His Ser Met His Ser Pro Glu Gln Asp Lys Ala Gly Val 35 40 45 Val Phe Tyr Ala Ile Ile Thr Pro Leu Leu Asn Pro Leu Ile Tyr Ser 50 55 60 Leu Arg Asn Lys Glu Val Ile Arg Ala Ile Glu Arg Met 65 70 75

<210> 205 <211> 939 <212> DNA <213> Canis familiaris <400> 205

atgaacatct ggaacaccac ctcagatttc attctcctgg gactctttaa ctacacagaa 60 gcccacctat ttctctttgt gatgattctg acaattgcct tcagctccct ggtgggcaat 120 gccctcatga ttctcctgat tcaccaagat ttccagctcc acacacccat gtacttccta 180 ctgagtcaac tctccctcat ggacatgatg ctgatctcca ccattgtgcc caaaatggca 240 gctgactact tgagtggcaa gaagtccatc tcccctgctg gctgtgggct tcagatcttc 300 ttcttcatca ctttggaagg gagcgagtgc ttcctcttag catccatgtc ctatgaccgc 360 tatgtggctg tttgccaccc actgaggtac cccgttctca tgagctggca attatgcctg 420 agaatgaccg tggggtcctg gtccctgggg gcagctgatg ggctcatgca ggctgctgcc 480 accctgagtt ttccattctg tgatgcacat gagatcaatc atttcttctg tgaggccccc 540 actctggtgc gtttggcttg tgctgacacg tttgtttttg agtatgtcat gtatatctgc 600 tgtgtattaa tgctgctggt tccgttttct ctcatcctga tttcctatag tctcatcctt 660 gctgtggttc tccagatgcg ttctagagaa gcccgcaaga aagcttttgc cacctgctcc 720 tcacatctga ctgtggtggg actcttttat ggagcagcta tttttattta catgagaccc 780 aaatcctaca ggtcagctaa ccacgataaa gtggtgtcag ccttctatac tatcttcacc 840 ccagtgctga accccattat ctacagtctt agaaacagtg aagtcaaagg agccctgaga 900

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069269_0225_SL.TXT aagtgtatgg gtcaatgtgc taccataaat catgagtaa

939 <210> 206 <211> 312 <212> PRT <213> Canis familiaris <400> 206

Met 1 Asn Ile Trp Asn 5 Thr Thr Ser Asn Tyr Thr Glu 20 Ala His Leu Phe Ala Phe Ser 35 Ser Leu Val Gly Asn 40 Gln Asp 50 Phe Gln Leu His Thr 55 Pro Ser 65 Leu Met Asp Met Met 70 Leu Ile Ala Asp Tyr Leu Ser 85 Gly Lys Lys Leu Gln Ile Phe 100 Phe Phe Ile Thr Leu Ala Ser 115 Met Ser Tyr Asp Arg 120 Arg Tyr 130 Pro Val Leu Met Ser 135 Trp Gly 145 Ser Trp Ser Leu Gly 150 Ala Ala Thr Leu Ser Phe Pro 165 Phe Cys Asp

Asp Phe 10 Ile Leu Leu Gly Leu 15 Phe Leu 25 Phe Val Met Ile Leu 30 Thr Ile Ala Leu Met Ile Leu 45 Leu Ile His Met Tyr Phe Leu 60 Leu Ser Gln Leu Ser Thr Ile 75 Val Pro Lys Met Ala 80 Ser Ile 90 Ser Pro Ala Gly Cys 95 Gly Leu 105 Glu Gly Ser Glu Cys 110 Phe Leu Tyr Val Ala Val Cys 125 His Pro Leu Gln Leu Cys Leu 140 Arg Met Thr Val Asp Gly Leu 155 Met Gln Ala Ala Ala 160 Ala His 170 Glu Ile Asn His Phe 175 Phe

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Cys Glu Ala Pro Thr Leu Val Arg Leu Ala Cys Ala Asp Thr Phe Val 180 185 190 Phe Glu Tyr Val Met Tyr Ile Cys Cys Val Leu Met Leu Leu Val Pro 195 200 205 Phe Ser Leu Ile Leu Ile Ser Tyr Ser Leu Ile Leu Ala Val Val Leu 210 215 220 Gln Met Arg Ser Arg Glu Ala Arg Lys Lys Ala Phe Ala Thr Cys Ser 225 230 235 240 Ser His Leu Thr Val Val Gly Leu Phe Tyr Gly Ala Ala Ile Phe Ile 245 250 255 Tyr Met Arg Pro Lys Ser Tyr Arg Ser Ala Asn His Asp Lys Val Val 260 265 270 Ser Ala Phe Tyr Thr Ile Phe Thr Pro Val Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Ser Glu Val Lys Gly Ala Leu Arg Lys Cys Met Gly 290 295 300 Gln Cys Ala Thr Ile Asn His Glu

305 310 <210> 207 <211> 939 <212> DNA <213> Canis familiaris <400> 207 atgaaaattg ggaactccac ctcagatttc attctcctgg gactctttaa ctacacagaa gcccacctgt ttctctttgt gatggttctg acaattgctt tcagctccct ggtgggcaat gccctcatga ttctcctgat tcaccaggat gtccggctcc acacacctat gtacttccta ctgagtcaac tctccctcat ggacatgatg ctgatctcca ccattgtgcc caaaatggca

120

180

240

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gctgactact tgagtggcaa gaagtccatc tcccctgctg gctgcgggtt gcagatattt 300 ttcttcctta ctttggcagg gggcgagtgc ttcctcttag cagccatgtc ctatgaccgc 360 tatgtggctg tttgccaccc actgaggtac cccattctca tgagctggca attatgcctg 420 agaatgacag tggggtcctg gtgcttgggg gcagctgatg ggctcatgca ggctgctgcc 480 accctgagtt ttccattctg tgatgcacat gagatcaatc atttcttctg tgaggccccc 540 actctggtgc gtttggcttg tgctgacacg tttgtttttg agtatgtcat gtatatctgc 600 tgtgtattaa tgctgctggt tccgttttct ctcatcctga tttcctatag tctcatcctt 660 gctgtggttc tccagatgcg ttctagagaa gcccgcaaga aggctttctc cacctgctcc 720 tcacatctga ctgtggtggg actcttttat ggagcagcta tttttattta catgagaccc 780 aaatcctaca ggtcagctaa ccacgataaa gtggtgtcag ccttctatac tatcttcacc 840 ccagtgctga accccattat ctacagtctt agaaacagtg aagtcaaagg agccctgaga 900 aagtgtatgg gtcaatgtgc taccataaat catgagtaa 939

<210> 208 <211> 312 <212> PRT <213> Canis familiaris <400> 208

Met 1 Lys Ile Gly Asn 5 Ser Thr Ser Asp Phe Ile Leu Leu Gly Leu Phe 10 15 Asn Tyr Thr Glu Ala His Leu Phe Leu Phe Val Met Val Leu Thr Ile 20 25 30 Ala Phe Ser Ser Leu Val Gly Asn Ala Leu Met Ile Leu Leu Ile His 35 40 45 Gln Asp Val Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu 50 55 60 Ser Leu Met Asp Met Met Leu Ile Ser Thr Ile Val Pro Lys Met Ala 65 70 75 80 Ala Asp Tyr Leu Ser Gly Lys Lys Ser Ile Ser Pro Ala Gly Cys Gly

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85 90 95

Leu Gln Ile Phe Phe Phe Leu Thr Leu Ala Gly Gly Glu Cys Phe Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Val Cys His Pro Leu 115 120 125 Arg Tyr Pro Ile Leu Met Ser Trp Gln Leu Cys Leu Arg Met Thr Val 130 135 140 Gly Ser Trp Cys Leu Gly Ala Ala Asp Gly Leu Met Gln Ala Ala Ala 145 150 155 160 Thr Leu Ser Phe Pro Phe Cys Asp Ala His Glu Ile Asn His Phe Phe 165 170 175 Cys Glu Ala Pro Thr Leu Val Arg Leu Ala Cys Ala Asp Thr Phe Val 180 185 190 Phe Glu Tyr Val Met Tyr Ile Cys Cys Val Leu Met Leu Leu Val Pro 195 200 205 Phe Ser Leu Ile Leu Ile Ser Tyr Ser Leu Ile Leu Ala Val Val Leu 210 215 220 Gln Met Arg Ser Arg Glu Ala Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Leu Thr Val Val Gly Leu Phe Tyr Gly Ala Ala Ile Phe Ile 245 250 255 Tyr Met Arg Pro Lys Ser Tyr Arg Ser Ala Asn His Asp Lys Val Val 260 265 270 Ser Ala Phe Tyr Thr Ile Phe Thr Pro Val Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Ser Glu Val Lys Gly Ala Leu Arg Lys Cys Met Gly

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290 295 300

Gln Cys Ala Thr Ile Asn His Glu

305 310 <210> 209 <211> 939 <212> DNA <213> Canis familiaris <400> 209

atgaacatct ggaacaacac ctcagatttc attctcctag gactctttaa ctacacagaa 60 gcccacctgt ttctctttgt gatggttctg acaattgctt tcagctccct ggtgggcaat 120 gccctcatga ttctcctgat tcatcaggat gtccatctcc acacacccat gtacttccta 180 ctgagtcaac tctccctcat ggacatgatg ctgatctcca ccattgtgcc caaaatggca 240 gctgactact tgagtggcaa gaagtccatc tcccctgctg gctgcgggtt gcagatattt 300 ttcttcctta ctttggcagg gggcgagtgc ttcctcttag cagccatgtc ctatgaccgc 360 tatgtggctg tttgccaccc actgaggtac cccattctca tgagctggca attatgcctg 420 agaatgacag tggggtcctg gttcttgggg gcagctgatg ggctcatgca ggctgctgcc 480 accctgagtt ttccattctg tgatgcacat gagatcaatc atttcttctg tgaggccccc 540 actctggtgc gtttggcttg tgctgacacg tttgtttttg agtatgtcat gtatatctgc 600 tgtgtattaa tgctgctggt tccgttttct ctcatcctga tttcctatag tctcatcctt 660 gctgtggttc tccagatgcg ttctagagaa gcccgcaaga aggctttctc cacctgctcc 720 tcacatctgt ctgtggtggg actcttttat ggagctggca tttttaccta catgggaccc 780 aaatcctata ggtcagctaa ccacgataaa atagtgtcag tgttctatac aatctttact 840 cctttattga accccctgat ctacagtatg aggaatagtg aagtcaaggg agccctgaga 900 aagtgtatgg gtcaatgtgc tgccttaagt cataactga 939

<210> 210 <211> 312 <212> PRT <213> Canis familiaris <400> 210

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Met 1 Asn Ile Trp Asn 5 Asn Thr Ser Asp Phe Ile Leu Leu Gly Leu Phe 10 15 Asn Tyr Thr Glu Ala His Leu Phe Leu Phe Val Met Val Leu Thr Ile 20 25 30 Ala Phe Ser Ser Leu Val Gly Asn Ala Leu Met Ile Leu Leu Ile His 35 40 45 Gln Asp Val His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu 50 55 60 Ser Leu Met Asp Met Met Leu Ile Ser Thr Ile Val Pro Lys Met Ala 65 70 75 80 Ala Asp Tyr Leu Ser Gly Lys Lys Ser Ile Ser Pro Ala Gly Cys Gly 85 90 95 Leu Gln Ile Phe Phe Phe Leu Thr Leu Ala Gly Gly Glu Cys Phe Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Val Cys His Pro Leu 115 120 125 Arg Tyr Pro Ile Leu Met Ser Trp Gln Leu Cys Leu Arg Met Thr Val 130 135 140 Gly Ser Trp Phe Leu Gly Ala Ala Asp Gly Leu Met Gln Ala Ala Ala 145 150 155 160 Thr Leu Ser Phe Pro Phe Cys Asp Ala His Glu Ile Asn His Phe Phe 165 170 175 Cys Glu Ala Pro Thr Leu Val Arg Leu Ala Cys Ala Asp Thr Phe Val 180 185 190 Phe Glu Tyr Val Met Tyr Ile Cys Cys Val Leu Met Leu Leu Val Pro 195 200 205

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Phe Ser Leu Ile Leu Ile Ser Tyr 215 Ser Leu Ile Leu Ala Val Val Leu 220 210 Gln Met Arg Ser Arg Glu Ala Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Leu Ser Val Val Gly Leu Phe Tyr Gly Ala Gly Ile Phe Thr 245 250 255 Tyr Met Gly Pro Lys Ser Tyr Arg Ser Ala Asn His Asp Lys Ile Val 260 265 270 Ser Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Met Arg Asn Ser Glu Val Lys Gly Ala Leu Arg Lys Cys Met Gly 290 295 300 Gln Cys Ala Ala Leu Ser His Asn 305 310

<210> 211 <211> 993 <212> DNA <213> Canis familiaris <400> 211 atggagaaat ggaatcaaac ttcaaatgat ttcattttgt tggggttgtt tccctcaaat 60 caaactggcc tgcttctctt gtccctcatt atcttcatct tcattgtcgc ctcagtgggt 120 aactcagcca tgattcatct catacgctta gatgcccggc tccacaccac aatgtacttc 180 ctcctcagcc agctctccct catggaccta atgtatatct ccaccactgt cccaaagatg 240 gcattcgact tcctgtctgg ccagaaaggt atctccttcc tgggatgtgg ggtgcaaagc 300 ttcttcttcc tgaccatggc atgttctgaa ggtttactct tgtcctccat ggcctatgac 360 cgttatgtgg ccatctgcca ccctctccag tatactgtcc gcatgagtaa aaccgtgtgt 420 gtgaaaatga tcataggatc ttggattttg gggtctatca actccttggc acacactgtc 480 tatgccctcc atattcctta ttgccggtcc agggccatta atcacttctt ctgtgatgtg 540

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ccagccatgt tggccttggc ctgtatagac acctgggcct atgagtacat ggtttttgtg 600 agtacaagtc tctttctcct ctttcctttc cttggcatta ctgcttccta tggatgggtt 660 ctttttgctg tctaccacat gcgctcaaaa gagggaagga aaaaggcctt cacaacctgc 720 tcaacacatt taactgtagt gacgttttac tatgcacctt ttgtgtacac ctacctgcgg 780 cccaggaatc tccgctcacc agcagaagat aagatcctgg cagtcttcta caccatcctc 840 acccccatgc tcaatcccat tatctacagc ctgaggaata aggaggttct gggggctatg 900 acaagacagt ttggaatatt ctctgccaag aaacaaaagt catggctgtc ctttcccttc 960 ttttcctttt ccaggttaat tagaacatcc tag 993

<210> 212 <211> 330 <212> PRT <213> Canis familiaris <400> 212

Met Glu Lys Trp Asn Gln Thr Ser Asn Asp Phe Ile Leu Leu Gly Leu 1 5 10 15 Phe Pro Ser Asn Gln Thr Gly Leu Leu Leu Leu Ser Leu Ile Ile Phe 20 25 30 Ile Phe Ile Val Ala Ser Val Gly Asn Ser Ala Met Ile His Leu Ile 35 40 45 Arg Leu Asp Ala Arg Leu His Thr Thr Met Tyr Phe Leu Leu Ser Gln 50 55 60 Leu Ser Leu Met Asp Leu Met Tyr Ile Ser Thr Thr Val Pro Lys Met 65 70 75 80 Ala Phe Asp Phe Leu Ser Gly Gln Lys Gly Ile Ser Phe Leu Gly Cys 85 90 95 Gly Val Gln Ser Phe Phe Phe Leu Thr Met Ala Cys Ser Glu Gly Leu 100 105 110 Leu Leu Ser Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro

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115 069269_0225_SL.TXT 120 125 Leu Gln Tyr Thr Val Arg Met Ser Lys Thr Val Cys Val Lys Met Ile 130 135 140 Ile Gly Ser Trp Ile Leu Gly Ser Ile Asn Ser Leu Ala His Thr Val 145 150 155 160 Tyr Ala Leu His Ile Pro Tyr Cys Arg Ser Arg Ala Ile Asn His Phe 165 170 175 Phe Cys Asp Val Pro Ala Met Leu Ala Leu Ala Cys Ile Asp Thr Trp 180 185 190 Ala Tyr Glu Tyr Met Val Phe Val Ser Thr Ser Leu Phe Leu Leu Phe 195 200 205 Pro Phe Leu Gly Ile Thr Ala Ser Tyr Gly Trp Val Leu Phe Ala Val 210 215 220 Tyr His Met Arg Ser Lys Glu Gly Arg Lys Lys Ala Phe Thr Thr Cys 225 230 235 240 Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Val Tyr 245 250 255 Thr Tyr Leu Arg Pro Arg Asn Leu Arg Ser Pro Ala Glu Asp Lys Ile 260 265 270 Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Leu Gly Ala Met Thr Arg Gln Phe 290 295 300 Gly Ile Phe Ser Ala Lys Lys Gln Lys Ser Trp Leu Ser Phe Pro Phe 305 310 315 320

Phe Ser Phe Ser Arg Leu Ile Arg Thr Ser

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069269_0225_SL.TXT 325 330 <210> 213 <211> 945 <212> DNA <213> Canis familiaris <400> 213

atggagaaga gcaacacaac catagatttc attctcctag gactctttaa tcacacaaga 60 tcccaccttt ttctcttcat tgtggtgatg acaatagcca ttgcttccct gaatggaaat 120 gccctcattc ttctcctgat tctcctggat tcccggttcc acacacctat gtacttctta 180 ctaagccaac tctctctcat ggacatgacg ttggtctcca ccattgtgcc caaaatggca 240 gctgactact tgagtggcaa gaagtccata tcccctgctg gctgtggatt gcagatcttt 300 gtctcactca cactgggcgg tggagaaagt ttcctcttag catccatgtc ctatgaccgc 360 tatgtggctg tttgccaccc actgagatac cctgttctca tgagctggca attatgcctg 420 agaatgactg tggggtcttg gttccttggg gcagctgatg ggctcatgca ggctgctgcc 480 accctgagtt ttccattttg cagggctaat gaaattgatc atttcttctg tgaggccccc 540 atactggtgc gtttggcttg tgctgacacg tcagtctttg aaaatgtcat gtacatctgc 600 tgtgtgttaa tgcttctggt ccccttttcc ctcatcctga cttcctatag tctcatcctc 660 tcatctgttc ttcagatgcg tactacagaa gcccgcaaga aggctttctc cacctgctcc 720 tcacatctct ctgtggtggg actcttttat ggagctgcta tttttattta catgagaccc 780 aaatcataca ggtcagataa ccatgataaa gtggtctcag ccttctatac gattttcacc 840 cctgtgttga accccctcat ctacagtcta aggaatagtg aagtcaaggg agccttgaaa 900 agatggttga ggaaatgtgc aaatgtaaaa ccccagtaca cttag 945

<210> 214 <211> 314 <212> PRT <213> Canis familiaris <400> 214

Met Glu Lys Ser Asn Thr Thr Ile Asp Phe Ile Leu Leu Gly Leu Phe 1 5 10 15

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Asn His Thr Arg Ser 20 His Leu Phe Leu Phe Ile Val Val Met Thr Ile 25 30 Ala Ile Ala Ser Leu Asn Gly Asn Ala Leu Ile Leu Leu Leu Ile Leu 35 40 45 Leu Asp Ser Arg Phe His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu 50 55 60 Ser Leu Met Asp Met Thr Leu Val Ser Thr Ile Val Pro Lys Met Ala 65 70 75 80 Ala Asp Tyr Leu Ser Gly Lys Lys Ser Ile Ser Pro Ala Gly Cys Gly 85 90 95 Leu Gln Ile Phe Val Ser Leu Thr Leu Gly Gly Gly Glu Ser Phe Leu 100 105 110 Leu Ala Ser Met Ser Tyr Asp Arg Tyr Val Ala Val Cys His Pro Leu 115 120 125 Arg Tyr Pro Val Leu Met Ser Trp Gln Leu Cys Leu Arg Met Thr Val 130 135 140 Gly Ser Trp Phe Leu Gly Ala Ala Asp Gly Leu Met Gln Ala Ala Ala 145 150 155 160 Thr Leu Ser Phe Pro Phe Cys Arg Ala Asn Glu Ile Asp His Phe Phe 165 170 175 Cys Glu Ala Pro Ile Leu Val Arg Leu Ala Cys Ala Asp Thr Ser Val 180 185 190 Phe Glu Asn Val Met Tyr Ile Cys Cys Val Leu Met Leu Leu Val Pro 195 200 205 Phe Ser Leu Ile Leu Thr Ser Tyr Ser Leu Ile Leu Ser Ser Val Leu 210 215 220

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Gln 225 Met Arg Thr Thr Glu Ala 230 Arg Lys Lys Ala Phe Ser Thr Cys Ser 235 240 Ser His Leu Ser Val Val Gly Leu Phe Tyr Gly Ala Ala Ile Phe Ile 245 250 255 Tyr Met Arg Pro Lys Ser Tyr Arg Ser Asp Asn His Asp Lys Val Val 260 265 270 Ser Ala Phe Tyr Thr Ile Phe Thr Pro Val Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Ser Glu Val Lys Gly Ala Leu Lys Arg Trp Leu Arg 290 295 300 Lys Cys Ala Asn Val Lys Pro Gln Tyr Thr 305 310

<210> 215 <211> 939 <212> DNA <213> Canis familiaris <400> 215

atgaacatct ggaacaccac ctcagatttc attctcctgg gactctttca ccacacagaa 60 gcccaccttt ttctcttttc aatggttctg acaattgctt ttggctccct catgggcaat 120 gccctcatga ttctcctgat tcaccaggat gtccggctcc acacacccat gtacttccta 180 ctgagtcaac tctccctcat ggacatgatg ctgatctcca ccattgtgcc caaaatggca 240 gctgactact tgagtggcaa gaagtccatc tcccctgctg gctgtgggct tcagatcttc 300 ttcttcatca ctttggaagg gagcgagtgc ttcctcttag catccatgtc ctatgaccgc 360 tatgtggctg tttgccaccc actgaggtac cccgttctca tgagctggca attatgcctg 420 agaatgaccg tggggtcctg gtccctgggg gcagctgatg ggctcatgca ggctgctgcc 480 accctgagtt ttccattctg tggtgcacat gagatcaatc atttcttctg tgaggccccc 540 actctggtgc gtttggcttg tgctgacacg tttgtttttg agtatgtcat gtatatctgc 600 tgtgtattaa tgctgctggt tccgttttct ctcatcctga tttcctatag tctcatcctt 660

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069269_0225_SL.TXT gctgcagttc tccagatgca ttctagagaa gcccgcaaga aagcttttgc cacctgctcc tcacatctct ctgtggtggg actcttttat ggagctgcta tttttatcta catgagaccc aaatcctata ggtcagctaa ccatgataaa atagtgtcag tgttctatac gatcttcact cctttattga accccatcat ctatagtatg aggaacagtg aagtcaaggg agccttgaga aagtgtatgg gtcaatgtgc tgccttacat cataaataa

720

780

840

900

939 <210> 216 <211> 312 <212> PRT <213> Canis familiaris <400> 216

Met Asn Ile 1 Trp Asn Thr Thr Ser 5 Asp Phe Ile Leu Leu Gly Leu Phe 10 15 His His Thr Glu Ala His Leu Phe Leu Phe Ser Met Val Leu Thr Ile 20 25 30 Ala Phe Gly Ser Leu Met Gly Asn Ala Leu Met Ile Leu Leu Ile His 35 40 45 Gln Asp Val Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu 50 55 60 Ser Leu Met Asp Met Met Leu Ile Ser Thr Ile Val Pro Lys Met Ala 65 70 75 80 Ala Asp Tyr Leu Ser Gly Lys Lys Ser Ile Ser Pro Ala Gly Cys Gly 85 90 95 Leu Gln Ile Phe Phe Phe Ile Thr Leu Glu Gly Ser Glu Cys Phe Leu 100 105 110 Leu Ala Ser Met Ser Tyr Asp Arg Tyr Val Ala Val Cys His Pro Leu 115 120 125 Arg Tyr Pro Val Leu Met Ser Trp Gln Leu Cys Leu Arg Met Thr Val 130 135 140

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Gly 145 Ser Trp Ser Leu Gly Ala Ala Asp Gly Leu Met Gln Ala Ala Ala 150 155 160 Thr Leu Ser Phe Pro Phe Cys Gly Ala His Glu Ile Asn His Phe Phe 165 170 175 Cys Glu Ala Pro Thr Leu Val Arg Leu Ala Cys Ala Asp Thr Phe Val 180 185 190 Phe Glu Tyr Val Met Tyr Ile Cys Cys Val Leu Met Leu Leu Val Pro 195 200 205 Phe Ser Leu Ile Leu Ile Ser Tyr Ser Leu Ile Leu Ala Ala Val Leu 210 215 220 Gln Met His Ser Arg Glu Ala Arg Lys Lys Ala Phe Ala Thr Cys Ser 225 230 235 240 Ser His Leu Ser Val Val Gly Leu Phe Tyr Gly Ala Ala Ile Phe Ile 245 250 255 Tyr Met Arg Pro Lys Ser Tyr Arg Ser Ala Asn His Asp Lys Ile Val 260 265 270 Ser Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Met Arg Asn Ser Glu Val Lys Gly Ala Leu Arg Lys Cys Met Gly 290 295 300 Gln Cys Ala Ala Leu His His Lys

305 310 <210> 217 <211> 855 <212> DNA <213> Canis familiaris <400> 217 atggacacgt tcctctttgt cgccattgta atcctttttt ctgtagctct gatggagaac Page 237

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atcatactgg tccttctaat tcaggtggac accagactcc acactccaat gtactttcta 120 ctcagccagc tctcctttat tgacatgatg tacatatcca cgaccgtgcc caagttgacc 180 actaacttcc tgtcaaacag taagaatatt acatttttgg gatgtgaaat tcaagccttt 240 gtattcttgg cccttggtgg gactgaagct cttctccttg gtttcatgtc ttatgatcga 300 tatttagcca tctgtcaccc tttacgttat cctatcctta tgagcaagaa gatctgttgg 360 ttcatggtta caagtgcatg gaccagtagt tctaccaatg ctttagtaca tacactgtat 420 gtatttcaac ttccattttg taggtctcgg attgttaacc actttttctg tgaagttcca 480 tctctattgc cactggtgtg tcaggatact tcccagtatg agtatacaat cctcctgagt 540 ggggtaatta ttctgctgct accattcttg gacatcctag cttcctatgc ccaagtactt 600 actgttgtgt tccagataag cttaggtaaa ggacagacaa aagctgtctc cacttgctcc 660 tctcacctga ttgtagcaag cctattctat gtgactactc tctctactta taccaggcca 720 cactccatgc attctccaga acaagataaa gcagtggcag tgttttacac catcatcaca 780 cctcttctga acccatttat ctatagcctg aggaataaag agtttactag ggccatgaga 840 agattgttgg cataa 855

<210> 218 <211> 284 <212> PRT <213> Canis familiaris <400> 218

Met Asp Thr Phe Leu Phe Val Ala Ile Val Ile Leu Phe Ser Val Ala 1 5 10 15 Leu Met Glu Asn Ile Ile Leu Val Leu Leu Ile Gln Val Asp Thr Arg 20 25 30 Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu Ser Phe Ile Asp 35 40 45 Met Met Tyr Ile Ser Thr Thr Val Pro Lys Leu Thr Thr Asn Phe Leu 50 55 60

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Ser 65 Asn Ser Lys Asn Ile Thr Phe Leu Gly Cys Glu Ile Gln Ala Phe 70 75 80 Val Phe Leu Ala Leu Gly Gly Thr Glu Ala Leu Leu Leu Gly Phe Met 85 90 95 Ser Tyr Asp Arg Tyr Leu Ala Ile Cys His Pro Leu Arg Tyr Pro Ile 100 105 110 Leu Met Ser Lys Lys Ile Cys Trp Phe Met Val Thr Ser Ala Trp Thr 115 120 125 Ser Ser Ser Thr Asn Ala Leu Val His Thr Leu Tyr Val Phe Gln Leu 130 135 140 Pro Phe Cys Arg Ser Arg Ile Val Asn His Phe Phe Cys Glu Val Pro 145 150 155 160 Ser Leu Leu Pro Leu Val Cys Gln Asp Thr Ser Gln Tyr Glu Tyr Thr 165 170 175 Ile Leu Leu Ser Gly Val Ile Ile Leu Leu Leu Pro Phe Leu Asp Ile 180 185 190 Leu Ala Ser Tyr Ala Gln Val Leu Thr Val Val Phe Gln Ile Ser Leu 195 200 205 Gly Lys Gly Gln Thr Lys Ala Val Ser Thr Cys Ser Ser His Leu Ile 210 215 220 Val Ala Ser Leu Phe Tyr Val Thr Thr Leu Ser Thr Tyr Thr Arg Pro 225 230 235 240 His Ser Met His Ser Pro Glu Gln Asp Lys Ala Val Ala Val Phe Tyr 245 250 255 Thr Ile Ile Thr Pro Leu Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn 260 265 270

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Lys Glu Phe Thr Arg Ala Met Arg Arg Leu Leu Ala 275 280 <210> 219 <211> 936 <212> DNA <213> Canis familiaris <400> 219

atggcattgg acaatcagac ttttaactct gatttcatcc ttctgggaat cttcaattac 60 agccccactc acatcttcct cttttctatg cttttggtca tcttcacagt ggtcttcatg 120 ggaaacactg ctatgattct cctcatctac ctggacactc agctccacac acccatgtac 180 ttctttctca gccaactgtc cctcatggac ctcatgctca tctgcaccac tgtacccaag 240 atggctttta actatttgtc tggcagcaat tccatttctg tggtagagtg tgctacacaa 300 attttcctct atacatcact acttggctgt gaacgtttcc tatgggcagt aatggcttat 360 gaccgctata ttgccatttg ctaccctcta agatatccta atcttatgag ccctaaaatt 420 tgtggactta tggctgcatc ttcctggatc ctgggctcta ctgattgtat cattgatgct 480 gtagctacat ttttcttctt ctattgtggg tcccgggaaa tagaccactt ctgtgatttt 540 ccttccctgc tcatcatctc atgcaacgac acatcaacat ttgaagaagt tcttttctac 600 tgctgtataa taatgattgt tttccctgta gtgatcatca ttgcttccta tactcatgtt 660 attgtggctg tcattcacat agcatctgga gagggtcacc agaaagtttt tgccacctgc 720 tcttctcacc tcatggtggt gggaatgtat tatggcacaa ctttgttcat atacatgcgg 780 cccgcttctg atcgttcccc cacccaggac aagatggtct ctgtcttcta caccattctc 840 actcccatgc cgaatcccct cgtctacagc ctccgcaaca aggaagtggc tagagcagcc 900 atgaaggtgt tggagaaggg caggtctgga cagtaa 936

<210> 220 <211> 311 <212> PRT <213> Canis familiaris <400> 220

Met Ala Leu Asp Asn Gln Thr Phe Asn Ser Asp Phe Ile Leu Leu Gly 1 5 10 15

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Ile Phe Asn Tyr Ser Pro Thr His Ile Phe Leu Phe Ser Met Leu Leu 20 25 30 Val Ile Phe Thr Val Val Phe Met Gly Asn Thr Ala Met Ile Leu Leu 35 40 45 Ile Tyr Leu Asp Thr Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Val Pro Lys 65 70 75 80 Met Ala Phe Asn Tyr Leu Ser Gly Ser Asn Ser Ile Ser Val Val Glu 85 90 95 Cys Ala Thr Gln Ile Phe Leu Tyr Thr Ser Leu Leu Gly Cys Glu Arg 100 105 110 Phe Leu Trp Ala Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Tyr 115 120 125 Pro Leu Arg Tyr Pro Asn Leu Met Ser Pro Lys Ile Cys Gly Leu Met 130 135 140 Ala Ala Ser Ser Trp Ile Leu Gly Ser Thr Asp Cys Ile Ile Asp Ala 145 150 155 160 Val Ala Thr Phe Phe Phe Phe Tyr Cys Gly Ser Arg Glu Ile Asp His 165 170 175 Phe Cys Asp Phe Pro Ser Leu Leu Ile Ile Ser Cys Asn Asp Thr Ser 180 185 190 Thr Phe Glu Glu Val Leu Phe Tyr Cys Cys Ile Ile Met Ile Val Phe 195 200 205 Pro Val Val Ile Ile Ile Ala Ser Tyr Thr His Val Ile Val Ala Val 210 215 220

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Ile His 225 Ile Ala Ser Gly Glu Gly His Gln Lys Val Phe Ala Thr Cys 230 235 240 Ser Ser His Leu Met Val Val Gly Met Tyr Tyr Gly Thr Thr Leu Phe 245 250 255 Ile Tyr Met Arg Pro Ala Ser Asp Arg Ser Pro Thr Gln Asp Lys Met 260 265 270 Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Met Pro Asn Pro Leu Val 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Ala Arg Ala Ala Met Lys Val Leu 290 295 300 Glu Lys Gly Arg Ser Gly Gln

305 310 <210> 221 <211> 858 <212> DNA <213> Canis familiaris <400> 221

tcccactcac atattttttt tttctcactg gtcttgggca tcttttcaat ggccttcttg 60 ggaaacactg tcctggttct tcttgtctac ctggacaccc atctccacat ctccatgtac 120 ttcctcctca gccagctctc cctcatggac ctcatgttca tctgcaccat tgtacccagg 180 caggtggcct tcaactactt gtctggcagc aagtcaatat ctctggcaga ttgtggagct 240 cagatattct tctatgtgtc cctgcttgga gctgaatgtt tcctgttggt tgtcatggcc 300 tatgaccatt atgtgactat atgccaccca ctttgataca ccatcctcat gaatcaggaa 360 ctctgtgtcc tcatgactgt tacttcctgg atcttgggct tttttgatag cattattgtg 420 ctagtagcag ccctgtcact gtctttctgt agctctccgg aaattcatca ctttttctgt 480 gatgttgctg cccttttccc tctatcttgc acagacacct ctgcttttga aaggctgctt 540 ttcctctgct gtgtggtgat gctaatatta ccagtgtctg tgatcattac ttcctattca 600 tatgtccttc aagctgtcct ccacatgagc tctagagaaa gtcacctcaa agccttcacc 660

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069269_0225_SL.TXT acctgttcct cccacctgac tgtggttgga ctgtactatg gtgctgctat gttcatgtat atgagaccag cttctaacca tacaccagac catgacaaga tagtatttat cttctacacc atcctcaccc ccatgctgaa ccctctcatc tacagtctcc acaacaaaga ggtatccagg ggacttcaga aactgttg

720

780

840

858 <210> 222 <211> 170 <212> PRT <213> Canis familiaris <400> 222

Met Asn Gln Glu 1 Leu 5 Cys Val Leu Met Thr Val Thr Ser Trp Ile Leu 10 15 Gly Phe Phe Asp Ser Ile Ile Val Leu Val Ala Ala Leu Ser Leu Ser 20 25 30 Phe Cys Ser Ser Pro Glu Ile His His Phe Phe Cys Asp Val Ala Ala 35 40 45 Leu Phe Pro Leu Ser Cys Thr Asp Thr Ser Ala Phe Glu Arg Leu Leu 50 55 60 Phe Leu Cys Cys Val Val Met Leu Ile Leu Pro Val Ser Val Ile Ile 65 70 75 80 Thr Ser Tyr Ser Tyr Val Leu Gln Ala Val Leu His Met Ser Ser Arg 85 90 95 Glu Ser His Leu Lys Ala Phe Thr Thr Cys Ser Ser His Leu Thr Val 100 105 110 Val Gly Leu Tyr Tyr Gly Ala Ala Met Phe Met Tyr Met Arg Pro Ala 115 120 125 Ser Asn His Thr Pro Asp His Asp Lys Ile Val Phe Ile Phe Tyr Thr 130 135 140

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Ile Leu Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu His Asn Lys 145 150 155 160

Glu Val Ser Arg Gly Leu Gln Lys Leu Leu 165 170 <210> 223 <211> 933 <212> DNA <213> Canis familiaris <400> 223

atgtcaaatt ccaccataat gatgggattt ctcctcacaa agttttctga tgtattggaa 60 ctacaagttt tttatgccat aaccttctct ataatgtatg tagtcactct gatggggaac 120 attctcattg ttactgtcac cacccttgac aggagtcttc acatagccat gtacttcttc 180 cttagaaatc tgtccatctt ggatgtctgc tacatttttg tgacagttcc taactcatgt 240 gtcaattctc tgcttaacag cagcaccatt tcaaaggctg ggtgtgtagt tcaggtcttc 300 ctagtggttt tctttgtata tgtggagctt ctgtttctat cagcttctgt ttctatcatg 360 gcccatgact gtcatgtggc tatctgccaa cctcttcact accctgtgat catgaaccct 420 caaatctgca tccaaatgac tctggcatcc atactcagtg gtctcattta tgcaggtgtg 480 cacactggca acacattccg gctccccttt tgtcaatccc atgttatcca tcagttttct 540 tgtgatattc cctctcttct aaagctctcc tgctctgaca ctttcagcaa taagatgctg 600 atctcatctt gtttcatctt tatcatcaga ttttacattc acatattttc tactgttctc 660 aaatttccag gtggagcaga cagaaaaaag gctttttctg cctctgtccc tcacatcatt 720 gtggtgtctg tcttcctcag ctcaggcttt tttgtatatc tgagaccatc tgaaaactct 780 tccataatgc aggacatgat cttttctgtt ttctattcca taatccctcc actcttcaac 840 cctattatct acagtcttag aaatgaacaa ataaaataag ccattaataa aatgaagaga 900 atgtttattc aggaaatgta caggaaattg ctg 933

<210> 224 <211> 292 <212> PRT <213> Canis familiaris

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<400> 224 Thr Ile Met Met Gly Phe Leu Leu Thr Lys Phe 15 Ser Met 1 Ser Asn Ser 5 10 Asp Val Leu Glu Leu Gln Val Phe Tyr Ala Ile Thr Phe Ser Ile Met 20 25 30 Tyr Val Val Thr Leu Met Gly Asn Ile Leu Ile Val Thr Val Thr Thr 35 40 45 Leu Asp Arg Ser Leu His Ile Ala Met Tyr Phe Phe Leu Arg Asn Leu 50 55 60 Ser Ile Leu Asp Val Cys Tyr Ile Phe Val Thr Val Pro Asn Ser Cys 65 70 75 80 Val Asn Ser Leu Leu Asn Ser Ser Thr Ile Ser Lys Ala Gly Cys Val 85 90 95 Val Gln Val Phe Leu Val Val Phe Phe Val Tyr Val Glu Leu Leu Phe 100 105 110 Leu Ser Ala Ser Val Ser Ile Met Ala His Asp Cys His Val Ala Ile 115 120 125 Cys Gln Pro Leu His Tyr Pro Val Ile Met Asn Pro Gln Ile Cys Ile 130 135 140 Gln Met Thr Leu Ala Ser Ile Leu Ser Gly Leu Ile Tyr Ala Gly Val 145 150 155 160 His Thr Gly Asn Thr Phe Arg Leu Pro Phe Cys Gln Ser His Val Ile 165 170 175 His Gln Phe Ser Cys Asp Ile Pro Ser Leu Leu Lys Leu Ser Cys Ser 180 185 190 Asp Thr Phe Ser Asn Lys Met Leu Ile Ser Ser Cys Phe Ile Phe Ile 195 200 205

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Ile Arg Phe Tyr Ile His Ile Phe Ser Thr Val Leu Lys Phe Pro Gly 210 215 220 Gly Ala Asp Arg Lys Lys Ala Phe Ser Ala Ser Val Pro His Ile Ile 225 230 235 240 Val Val Ser Val Phe Leu Ser Ser Gly Phe Phe Val Tyr Leu Arg Pro 245 250 255 Ser Glu Asn Ser Ser Ile Met Gln Asp Met Ile Phe Ser Val Phe Tyr 260 265 270 Ser Ile Ile Pro Pro Leu Phe Asn Pro Ile Ile Tyr Ser Leu Arg Asn 275 280 285

Glu Gln Ile Lys 290 <210> 225 <211> 936 <212> DNA <213> Canis familiaris <400> 225

atggcatggg ggaatcagac cttcaactca ggcttcatcc tgctgggaat cttcaattac 60 agccccaccc acatcttcct cttctcccta gtcttgggca tcttcacagt ggccttcatg 120 ggaaacactg ctatgattct cttcatctac ctggacactc agctccatac acccatgtac 180 ttcctcctca gccagctctc tctgatggac ctcatgcttg tctgcaccac tgtacccaag 240 atggccttca actatatgtc tggcagcaag tccatttctt tggctggctg tggagcccag 300 attttcttct atgtgtccct gcttggagca gaatgtttcc tgttggctac aatggcctat 360 gaccgttacg ttgccatttg tcacccatta cgatactcag ttctcatgaa tcagaaaatc 420 tattgtgtta tggttgtttc ttcctggacc attggctttc ttgatggtat aattgtcatt 480 gcagttgcac tttctttccc atattgtgga gcccgggaaa taccccactt tttctgtgat 540 gtccctgctc ttctcactct ctcatgtact actacattgc tctttgaaag gttaatgttt 600 atttgttgta taattatgcc tctctttcct gtagcagtaa tcattgcttc ctatgttcat 660

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069269_0225_SL.TXT gttattgtgg ctgtcattca catggggtct ggagagggat gacaaaaagc ttttgccaca tgttcctccc acctcatggt ggtgggaatg tattatggag cagctatgtt catatacatg cggcctgttt ctgatcgttc ccccacccag gacaagatgg tgtcagcctt ctacacgatc ctcactccca tgctgaatcc cctcatctat agcctccgca acaaggaagt atccagagca ttcatgaaga tgttggggaa gagcaagtct ggagag

720

780

840

900

936 <210> 226 <211> 233 <212> PRT <213> Canis familiaris <400> 226

Met 1 Ala Trp Gly Asn Gln Thr Phe Asn Ser Gly Phe Ile Leu Leu 15 Gly 5 10 Ile Phe Asn Tyr Ser Pro Thr His Ile Phe Leu Phe Ser Leu Val Leu 20 25 30 Gly Ile Phe Thr Val Ala Phe Met Gly Asn Thr Ala Met Ile Leu Phe 35 40 45 Ile Tyr Leu Asp Thr Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Met Asp Leu Met Leu Val Cys Thr Thr Val Pro Lys 65 70 75 80 Met Ala Phe Asn Tyr Met Ser Gly Ser Lys Ser Ile Ser Leu Ala Gly 85 90 95 Cys Gly Ala Gln Ile Phe Phe Tyr Val Ser Leu Leu Gly Ala Glu Cys 100 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Ser Val Leu Met Asn Gln Lys Ile Tyr Cys Val Met

130 135 140

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Val Val 145 Ser Ser Trp Thr Ile Gly Phe Leu Asp Gly Ile Ile Val Ile 150 155 160 Ala Val Ala Leu Ser Phe Pro Tyr Cys Gly Ala Arg Glu Ile Pro His 165 170 175 Phe Phe Cys Asp Val Pro Ala Leu Leu Thr Leu Ser Cys Thr Thr Thr 180 185 190 Leu Leu Phe Glu Arg Leu Met Phe Ile Cys Cys Ile Ile Met Pro Leu 195 200 205 Phe Pro Val Ala Val Ile Ile Ala Ser Tyr Val His Val Ile Val Ala 210 215 220 Val Ile His Met Gly Ser Gly Glu Gly

225 230 <210> 227 <211> 927 <212> DNA <213> Canis familiaris <400> 227

gcatgggaga accagacctt caactcaggc ttcatcctgc tgggaatctt caattacagc 60 cccacccaca tcttcctctt ctccctagtc ttgggcatct tcacagtggc cttcatggga 120 aacactgcta tgattctcct catctatctg gacactcagc tccatacacc catgtacttc 180 ctcctcagcc agctctctct gatggacctc atgcttgtct gcaccactgt acccaagatg 240 gccttcaact atatgtctgg cagcaagtcc atctctctgg ctggttgtgg agctcagata 300 ttcttctatg tgtccctgct tggagcagaa tgtttcctgt tggctacaat ggcctatgac 360 cgttatgttg ccatttgtca cccattacga tactcaattc tcatgaacca gaaaatctgt 420 ggtcttatgg cagcttgttc atggattctt ggctcccttg atggtataat tgaagttgca 480 gttgctttgt cattctcata ttgtggagcc cgggaaatac cccacttttt ttgtgatgtc 540 cctgcccttc tcattctctc atgcaccaac acattgttat ttgaaaggat gatatttatc 600

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069269_0225_SL.TXT tgttgtgtta ttatgcttct tttccctgta gcagtaatca ttgcttccta tgttcatgtt attgtggctg tcattcacat ggggtctggg gagggatgcc ggaaagcttt tgccacctgc tcctctcatc tcacagtggt gggaatgtat tatggagcag ccatgttcat atacatgcgg cccacttcag atcgttcccc cactcaggac aagatgatct ctgccttcta caccatcctt actcccatgc tgaatcccct catctacagc ctccgcaaca aggaagtagt cagagcattc ttgaagatgt tagggaaggg taagtct

660

720

780

840

900

927 <210> 228 <211> 309 <212> PRT <213> Canis familiaris <400> 228

Ala 1 Trp Glu Asn Gln Thr Phe Asn Ser Gly Phe Ile Leu Leu Gly Ile 5 10 15 Phe Asn Tyr Ser Pro Thr His Ile Phe Leu Phe Ser Leu Val Leu Gly 20 25 30 Ile Phe Thr Val Ala Phe Met Gly Asn Thr Ala Met Ile Leu Leu Ile 35 40 45 Tyr Leu Asp Thr Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 50 55 60 Leu Ser Leu Met Asp Leu Met Leu Val Cys Thr Thr Val Pro Lys Met 65 70 75 80 Ala Phe Asn Tyr Met Ser Gly Ser Lys Ser Ile Ser Leu Ala Gly Cys 85 90 95 Gly Ala Gln Ile Phe Phe Tyr Val Ser Leu Leu Gly Ala Glu Cys Phe 100 105 110 Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu Arg Tyr Ser Ile Leu Met Asn Gln Lys Ile Cys Gly Leu Met Ala

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130 135 140 Ala Cys Ser Trp Ile Leu Gly Ser Leu Asp Gly Ile Ile Glu Val Ala 145 150 155 160 Val Ala Leu Ser Phe Ser Tyr Cys Gly Ala Arg Glu Ile Pro His Phe 165 170 175 Phe Cys Asp Val Pro Ala Leu Leu Ile Leu Ser Cys Thr Asn Thr Leu 180 185 190 Leu Phe Glu Arg Met Ile Phe Ile Cys Cys Val Ile Met Leu Leu Phe 195 200 205 Pro Val Ala Val Ile Ile Ala Ser Tyr Val His Val Ile Val Ala Val 210 215 220 Ile His Met Gly Ser Gly Glu Gly Cys Arg Lys Ala Phe Ala Thr Cys 225 230 235 240 Ser Ser His Leu Thr Val Val Gly Met Tyr Tyr Gly Ala Ala Met Phe 245 250 255 Ile Tyr Met Arg Pro Thr Ser Asp Arg Ser Pro Thr Gln Asp Lys Met 260 265 270 Ile Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Val Arg Ala Phe Leu Lys Met Leu 290 295 300 Gly Lys Gly Lys Ser

305 <210> 229 <211> 963 <212> DNA <213> Canis familiaris

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069269_0225_SL.TXT <400> 229

atgaaaaaca tgaactggat ggccaattac actggagagt ctgatttcat cctggtggga 60 atcttcagtc aatcaaatca cccagctctc ctgtgtgtgg tcatttttgt agttttcttg 120 atggctttaa ctgggaatgc tgtcctgatt cttctgatac attttgatgc tcacctccac 180 actcctatgt actttttcat cagccagttg tctctcatgg atgtaatgta catttctatc 240 actgtgccca agatgctcat agaccagatc atgggtataa gtaatatatc agcccctgag 300 tgtggaatgc aaatgtttct ctatgtgaca ctagcgggtt cagaatgttt tcttctagcc 360 accatggcct atgatcgcta tatggccatc tgccatcctc ttcattaccc tgtcctcatg 420 aaccacagat tgtgtcttct actggcatct ggctgctggt ttctgggatc tgtggatgga 480 tttatgctca cgcccatcac tatgacgttc cctttctgca gatcccggga gatccatcat 540 ttcttctgtg aagtccctgc tgtaatgaag ctctcctgct cagatacctc cctttatgag 600 acagtcatgt acctgtgctg tgtcctcatg ctcctcatcc ctgtgacagt catttcaagc 660 tcctattatt tcatcctcct caccatccac aggatgaatt tagcagaggg tcagaagaag 720 gcctttgcca cttgttcttc ccatatgact gtggtcattc tcttctatgg ggctgctgtc 780 tatacctaca tgctccccac ctcctatcac acctctgaga aggacatgat tgtatctgtc 840 ttttatacca tcctcactcc tggattaaat cctttaatct acagtctcag gaataagaat 900 gtcatgggag cactgaagaa aatgttgaat gtgggacctg tttttcaaga aactataaaa 960

tag 963 <210> 230 <211> 320 <212> PRT <213> Canis familiaris <400> 230

Met 1 Lys Asn Met Asn 5 Trp Met Ala Asn Tyr Thr Gly Glu Ser Asp Phe 10 15 Ile Leu Val Gly Ile Phe Ser Gln Ser Asn His Pro Ala Leu Leu Cys 20 25 30 Val Val Ile Phe Val Val Phe Leu Met Ala Leu Thr Gly Asn Ala Val

35 40 45

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Leu Ile Leu Leu Ile His Phe Asp 55 Ala His Leu His 60 Thr Pro Met Tyr 50 Phe Phe Ile Ser Gln Leu Ser Leu Met Asp Val Met Tyr Ile Ser Ile 65 70 75 80 Thr Val Pro Lys Met Leu Ile Asp Gln Ile Met Gly Ile Ser Asn Ile 85 90 95 Ser Ala Pro Glu Cys Gly Met Gln Met Phe Leu Tyr Val Thr Leu Ala 100 105 110 Gly Ser Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Met 115 120 125 Ala Ile Cys His Pro Leu His Tyr Pro Val Leu Met Asn His Arg Leu 130 135 140 Cys Leu Leu Leu Ala Ser Gly Cys Trp Phe Leu Gly Ser Val Asp Gly 145 150 155 160 Phe Met Leu Thr Pro Ile Thr Met Thr Phe Pro Phe Cys Arg Ser Arg 165 170 175 Glu Ile His His Phe Phe Cys Glu Val Pro Ala Val Met Lys Leu Ser 180 185 190 Cys Ser Asp Thr Ser Leu Tyr Glu Thr Val Met Tyr Leu Cys Cys Val 195 200 205 Leu Met Leu Leu Ile Pro Val Thr Val Ile Ser Ser Ser Tyr Tyr Phe 210 215 220 Ile Leu Leu Thr Ile His Arg Met Asn Leu Ala Glu Gly Gln Lys Lys 225 230 235 240 Ala Phe Ala Thr Cys Ser Ser His Met Thr Val Val Ile Leu Phe Tyr 245 250 255

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Gly Ala Ala Val Tyr Thr 260 Tyr Met Leu 265 Pro Thr Ser Tyr His 270 Thr Ser Glu Lys Asp Met Ile Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Gly 275 280 285 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asn Val Met Gly Ala 290 295 300 Leu Lys Lys Met Leu Asn Val Gly Pro Val Phe Gln Glu Thr Ile Lys 305 310 315 320

<210> 231 <211> 960 <212> DNA <213> Canis familiaris <400> 231

atggacaaca aaacttggat gatcagtgac agtggacaat ctgatttcat cctggtggga 60 attttcagtc agtcaaaaca cccaactttt ctctgtgtga tcatttttat tgttttcttg 120 ttggtattgt ctggaaactc tctcctgata tttctgatat actctgatgc tcacctccac 180 actcccatgt attttttcat cagccagttg tctctcatgg atgtaatgta catttccatc 240 actgtaccca aaatgcttat gaaccaggtt ttgagtatga ataagatctc aaccctagaa 300 tgtgggatgc aaatgtttct ctatgtaaca ctaggaggtt cagaatgttt tcttctagcc 360 accatggctt atgatcgcta tgtagccatc tgccatcctc ttcattaccc tgtcctcatg 420 aaccatagat tgtgtcttct actggcatct ggctgctggt ttctgggatc tgtggatgga 480 ttcatgctca cgtccatcac catgaccttc cccttctgca gaactcgaga gatccatcat 540 ttcttctgtg aagtccctgc catagtgaag ctttcttgct cagatacttc cctctatgag 600 acagtcatgt acctgtgctg tgtcctcatg cttcttatcc ctgtagcagt catttcaagc 660 tcttattctt tcatcctttt caccattcac aggataaact cagcaaaaag ccagaaatcc 720 tttgccacgt gttcctccca tatgacggtg gtcattctct tttatggggc tggagtctac 780 aactatatgc ttcccagttt ttaccacacc cctgaaaaag acataatggt gtctgtcttt 840

Page 253

900

960

069269_0225_SL.TXT tataccatac ttactccatt gctaaaccct ttaatctata gtctgaggaa taaagatgtc acagaagctt taaagaaaat ggtgaatgta ggacctgtct ttcaagaaat tataaaatag <210> 232 <211> 319 <212> PRT <213> Canis familiaris <400> 232

Met Asp Asn Lys Thr Trp Met Ile Ser Asp Ser Gly Gln Ser Asp Phe 1 5 10 15 Ile Leu Val Gly Ile Phe Ser Gln Ser Lys His Pro Thr Phe Leu Cys 20 25 30 Val Ile Ile Phe Ile Val Phe Leu Leu Val Leu Ser Gly Asn Ser Leu 35 40 45 Leu Ile Phe Leu Ile Tyr Ser Asp Ala His Leu His Thr Pro Met Tyr 50 55 60 Phe Phe Ile Ser Gln Leu Ser Leu Met Asp Val Met Tyr Ile Ser Ile 65 70 75 80 Thr Val Pro Lys Met Leu Met Asn Gln Val Leu Ser Met Asn Lys Ile 85 90 95 Ser Thr Leu Glu Cys Gly Met Gln Met Phe Leu Tyr Val Thr Leu Gly 100 105 110 Gly Ser Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu His Tyr Pro Val Leu Met Asn His Arg Leu 130 135 140 Cys Leu Leu Leu Ala Ser Gly Cys Trp Phe Leu Gly Ser Val Asp Gly 145 150 155 160 Phe Met Leu Thr Ser Ile Thr Met Thr Phe Pro Phe Cys Arg Thr Arg

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165 170 175 Glu Ile His His Phe Phe Cys Glu Val Pro Ala Ile Val Lys Leu Ser 180 185 190 Cys Ser Asp Thr Ser Leu Tyr Glu Thr Val Met Tyr Leu Cys Cys Val 195 200 205 Leu Met Leu Leu Ile Pro Val Ala Val Ile Ser Ser Ser Tyr Ser Phe 210 215 220 Ile Leu Phe Thr Ile His Arg Ile Asn Ser Ala Lys Ser Gln Lys Ser 225 230 235 240 Phe Ala Thr Cys Ser Ser His Met Thr Val Val Ile Leu Phe Tyr Gly 245 250 255 Ala Gly Val Tyr Asn Tyr Met Leu Pro Ser Phe Tyr His Thr Pro Glu 260 265 270 Lys Asp Ile Met Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Leu Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Glu Ala Leu 290 295 300 Lys Lys Met Val Asn Val Gly Pro Val Phe Gln Glu Ile Ile Lys

305 310 315 <210> 233 <211> 963 <212> DNA <213> Canis familiaris <400> 233 atggagaaca tcaactggct ggctaaccac actgggaggt cagatttcat cctagtggga 60 ctcttcaata aatccaaaca cccagctctc ctttgtttgg tcatttttgt ggttttccta 120 atggccttgt ctggaaacac catcctgatt ctactgatac attctgattc ccacctccac 180 acccctatgt acttttttat cagccaacta tctctcatgg acatgatgta tatttccgtt 240

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069269_0225_SL.TXT actgtgccca agatgctcat ggaccaagtc tgtgggatac agatgtttct ctatgtgaca tccatggcct atgaccgcta tgtggccatc aaccatcagg tgttgctcat cctagcatct ttcttgttca ctcccatcac catgaccttc ttcttctgtg aagtccctgc tgtattgaaa gttttcatgt atctgtgctg tgtgctcatg tcttactact ttatcctcat caccatccac gcctttgcca cttgttcttc ccacatgact tatacttaca tgctccccaa ttcctaccat ttttacacca tactcactcc tgtgctaaac gttatgggag cgctgaagaa aatgctgaat tag <210> 234 <211> 320 <212> PRT <213> Canis familiaris atgggtatga ataagatctc agccacggaa ctagcaggtt cagaattttt tcttctagcc tgccatcctc tccgttaccc tatcctcatg ggctgctggt tcctgggctc agtggatggc cccttttgca gatctcggga gattcatcat ctctcttgtt cagacacttc catctatgag cttctcattc ctgtgacagt catttcaggc aggatgaact cagcagaagg ccagaagaag gtggtcatcc tcttctatgg ggctgccatt acacctgaga aggacatgat ggtatctgtc cctttgatct atagcttaag aaataaggat gtgggacctg gttttcaaga aactataaag

300

360

420

480

540

600

660

720

780

840

900

960

963 <400> 234

Met Glu Asn Ile Asn Trp Leu Ala 1 5 Ile Leu Val Gly Leu Phe Asn Lys 20 Leu Val Ile Phe Val Val Phe Leu 35 40 Leu Ile Leu Leu Ile His Ser Asp 50 55 Phe Phe Ile Ser Gln Leu Ser Leu 65 70

Asn His 10 Thr Gly Arg Ser Asp 15 Phe Ser 25 Lys His Pro Ala Leu 30 Leu Cys Met Ala Leu Ser Gly 45 Asn Thr Ile Ser His Leu His 60 Thr Pro Met Tyr Met Asp Met 75 Met Tyr Ile Ser Val 80

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Thr Val Pro Lys Met 85 Leu Met Asp Gln Val Met Gly Met Asn Lys Ile 90 95 Ser Ala Thr Glu Cys Gly Ile Gln Met Phe Leu Tyr Val Thr Leu Ala 100 105 110 Gly Ser Glu Phe Phe Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Ile Leu Met Asn His Gln Val 130 135 140 Leu Leu Ile Leu Ala Ser Gly Cys Trp Phe Leu Gly Ser Val Asp Gly 145 150 155 160 Phe Leu Phe Thr Pro Ile Thr Met Thr Phe Pro Phe Cys Arg Ser Arg 165 170 175 Glu Ile His His Phe Phe Cys Glu Val Pro Ala Val Leu Lys Leu Ser 180 185 190 Cys Ser Asp Thr Ser Ile Tyr Glu Val Phe Met Tyr Leu Cys Cys Val 195 200 205 Leu Met Leu Leu Ile Pro Val Thr Val Ile Ser Gly Ser Tyr Tyr Phe 210 215 220 Ile Leu Ile Thr Ile His Arg Met Asn Ser Ala Glu Gly Gln Lys Lys 225 230 235 240 Ala Phe Ala Thr Cys Ser Ser His Met Thr Val Val Ile Leu Phe Tyr 245 250 255 Gly Ala Ala Ile Tyr Thr Tyr Met Leu Pro Asn Ser Tyr His Thr Pro 260 265 270 Glu Lys Asp Met Met Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Val 275 280 285

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Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Met Gly Ala 290 295 300

Leu Lys Lys Met Leu Asn Val Gly Pro Gly Phe Gln Glu Thr Ile Lys 305 310 315 320 <210> 235 <211> 960 <212> DNA <213> Canis familiaris <400> 235

atggatggag acaatcaaac ctcttccagt gacttcatcc tcacagggct cttcactcac 60 agtgcaatct cagtcttcct tttcagcatc atctgtgcca tcttcttcat ggccatgatt 120 gctaatggtg tcatgatctt cctgatccat atagactctc acctccacac ccccatgtat 180 ttcctgctca gtcatctctc ttttattgac atgatgtaca tctctaccat tgtgcccaag 240 atgctgatcg attatctcgt gggcaagggg actatctcct tcattgcctg tacagcccag 300 tactttctct acatgggctt tgtgggggct gagtttttcc tgttgggact catggcttat 360 gaccgctatg tggccatctg caaccccctt cgctatcctg tccttatgag ccaccaggtc 420 tgttggatga tcttggccag ctcttggtta ggtggtgctt tggacagctt tctcctcacc 480 cctatcacca tgagtctccc attctgcagt tcccacaaga tcaatcactt cttctgtgaa 540 ggacccacca tgctaaggct ggcatgcggt gacaaagctg cctatgaaat ggtcatgtac 600 atttgctgtg tcatgatgtt gctgatcccc ttctctgtgg tgattgcttc ctatgctcag 660 attctcatca cggtgcacca gataaagtca gatgaaggaa agaagaaggc ttttgctacc 720 tgttcatcac acataatggt ggtgacattg ttttatgggg ctgccctata cacatatatg 780 cttccccaat cctaccacac accaatcaaa gacaaagtct tctctgcttt ttacaccatt 840 ctcactcctt tgttaaatcc tctcatctac agcttgagga acacagatgt aactgaagct 900 tttaaaagaa ttttggcaag atgtcaagga gctcctggtg tgacaaggag agaattctga 960

<210> 236 <211> 319 <212> PRT

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069269_0225_SL.TXT <213> Canis familiaris <400> 236

Met Asp Gly Asp Asn Gln Thr Ser Ser Ser Asp Phe Ile Leu Thr Gly 1 5 10 15 Leu Phe Thr His Ser Ala Ile Ser Val Phe Leu Phe Ser Ile Ile Cys 20 25 30 Ala Ile Phe Phe Met Ala Met Ile Ala Asn Gly Val Met Ile Phe Leu 35 40 45 Ile His Ile Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 His Leu Ser Phe Ile Asp Met Met Tyr Ile Ser Thr Ile Val Pro Lys 65 70 75 80 Met Leu Ile Asp Tyr Leu Val Gly Lys Gly Thr Ile Ser Phe Ile Ala 85 90 95 Cys Thr Ala Gln Tyr Phe Leu Tyr Met Gly Phe Val Gly Ala Glu Phe 100 105 110 Phe Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Leu Met Ser His Gln Val Cys Trp Met Ile 130 135 140 Leu Ala Ser Ser Trp Leu Gly Gly Ala Leu Asp Ser Phe Leu Leu Thr 145 150 155 160 Pro Ile Thr Met Ser Leu Pro Phe Cys Ser Ser His Lys Ile Asn His 165 170 175 Phe Phe Cys Glu Gly Pro Thr Met Leu Arg Leu Ala Cys Gly Asp Lys 180 185 190 Ala Ala Tyr Glu Met Val Met Tyr Ile Cys Cys Val Met Met Leu Leu

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195 200 205 Ile Pro Phe Ser Val Val Ile Ala Ser Tyr Ala Gln Ile Leu Ile Thr 210 215 220 Val His Gln Ile Lys Ser Asp Glu Gly Lys Lys Lys Ala Phe Ala Thr 225 230 235 240 Cys Ser Ser His Ile Met Val Val Thr Leu Phe Tyr Gly Ala Ala Leu 245 250 255 Tyr Thr Tyr Met Leu Pro Gln Ser Tyr His Thr Pro Ile Lys Asp Lys 260 265 270 Val Phe Ser Ala Phe Tyr Thr Ile Leu Thr Pro Leu Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Thr Asp Val Thr Glu Ala Phe Lys Arg Ile 290 295 300 Leu Ala Arg Cys Gln Gly Ala Pro Gly Val Thr Arg Arg Glu Phe

305 310 315 <210> 237 <211> 957 <212> DNA <213> Canis familiaris <400> 237

atggagatgc acaacacatc ctctacggac ttcaccttca tggggctgtt caacaggaag 60 gacatctccg gccttctttt tctcattatc tctatcatct ttttcactgc actgatggcc 120 aacggagtca tgatcttcct gattcgcacc gattcacgac ttcacacacc catgtacttc 180 ttgctcagcc acctctcctt cattgacatg atgtacatct ccaccattgt gccaaagatg 240 ctggttgatt acctacttgg tcaaagaacc atctccttta tggggtgcac agctcagcac 300 ttcctctacc tcaccctggt gggagctgag ttctttctgc tgggcctcat ggcctatgat 360 cgttatgtgg ccatctgcaa ccctcttcgc tatcctgttc ttatgagccg ccaggtctgt 420 tggatgatca tagcaggttc ctggtttggg ggctctttgg atggctttct tctaactcct 480

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atcaccatga gctttccttt ctgcaactcg cgagagatta atcatttctt ctgtgaggca 540 cctgcagtct tgaagttggc atgtgcagac acagccctct atgagacagt aatgtatgtg 600 tgctgtgttc tgatgctgct gattcctttc tctgtggtga tttcttccta tgctcgaatt 660 ctgaccacag tccaccacat gagttcagtg gaagggagga aaaaggcatt tgccacctgc 720 tcatctcaca taacagtggt gaccttgttc tatggggctg ccatgtacac ctacatgctg 780 ccacactctt accacaggcc agcccaggac aaagtctttt ctgtgttcta cacaatcctt 840 acaccaatgc taaatccact catctacagt ctgaggaaca aggatgtgac tggagctctg 900 aaaaaagcat tggccaggtt caagggtaca caaagggtgg caggagaagt gttttga 957

<210> 238 <211> 318 <212> PRT <213> Canis familiaris <400> 238

Met Glu Met His Asn Thr Ser Ser Thr Asp Phe Thr Phe Met Gly Leu 1 5 10 15 Phe Asn Arg Lys Asp Ile Ser Gly Leu Leu Phe Leu Ile Ile Ser Ile 20 25 30 Ile Phe Phe Thr Ala Leu Met Ala Asn Gly Val Met Ile Phe Leu Ile 35 40 45 Arg Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser His 50 55 60 Leu Ser Phe Ile Asp Met Met Tyr Ile Ser Thr Ile Val Pro Lys Met 65 70 75 80 Leu Val Asp Tyr Leu Leu Gly Gln Arg Thr Ile Ser Phe Met Gly Cys 85 90 95 Thr Ala Gln His Phe Leu Tyr Leu Thr Leu Val Gly Ala Glu Phe Phe 100 105 110

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Leu Leu Gly 115 Leu Met Ala Tyr 069269_0225_SL.TXT Asp Arg Tyr Val Ala Ile 120 125 Cys Asn Pro Leu Arg Tyr Pro Val Leu Met Ser Arg Gln Val Cys Trp Met Ile Ile 130 135 140 Ala Gly Ser Trp Phe Gly Gly Ser Leu Asp Gly Phe Leu Leu Thr Pro 145 150 155 160 Ile Thr Met Ser Phe Pro Phe Cys Asn Ser Arg Glu Ile Asn His Phe 165 170 175 Phe Cys Glu Ala Pro Ala Val Leu Lys Leu Ala Cys Ala Asp Thr Ala 180 185 190 Leu Tyr Glu Thr Val Met Tyr Val Cys Cys Val Leu Met Leu Leu Ile 195 200 205 Pro Phe Ser Val Val Ile Ser Ser Tyr Ala Arg Ile Leu Thr Thr Val 210 215 220 His His Met Ser Ser Val Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys 225 230 235 240 Ser Ser His Ile Thr Val Val Thr Leu Phe Tyr Gly Ala Ala Met Tyr 245 250 255 Thr Tyr Met Leu Pro His Ser Tyr His Arg Pro Ala Gln Asp Lys Val 260 265 270 Phe Ser Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Thr Gly Ala Leu Lys Lys Ala Leu 290 295 300 Ala Arg Phe Lys Gly Thr Gln Arg Val Ala Gly Glu Val Phe 305 310 315

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069269_0225_SL.TXT <210> 239 <211> 939 <212> DNA <213> Canis familiaris <400> 239

atggaaaatt atactcaaac atcaactgat ttcatccttt tgggcttgtt cccatcaaca 60 agaattggcc tgttcctttt tattgtcatc gttcttgttt tcctaatggc tctgtttggc 120 aacctgtcca tgattcttct catcttccta gacactcatc tccacacacc catgtatttc 180 ttactcagtc agctctctct cattgaccta aactacatct ccacaattgt ccccaagatg 240 gcttacaatt ttgtgtttgg aaacaagtct atctccttca ttgggtgtgg ggctcagagc 300 ttcttcttct tgacattagg aggagcagaa gcattgctcc taatatctat ggcctatgat 360 cgttatgtgg ctatttgctt tcctctccac tattccattc gtatgaacaa aaaagtgtgc 420 atgttgatga taacaggatc ttggataatg ggatcaatca actcctgtgc ccacactgca 480 tatgccttcc atatacctta ctgtcgatcc agaactatca accacttctt ctgtgatgtc 540 ccagccatgt tgactctggc ctgcatggac acctgggtct atgagtacac agtgtttgtc 600 agtaccatcc tcttccttgt gtttcctttc atttgcatta ctttttccta tatccgggtc 660 ctcctagcta tctgccgcat gcagtctaca gaagggagga agaaagctta ttccacctgc 720 agcacccacc taactgtggt gactttctac tatgtacctt ttgcttacac ttatttacgc 780 ccaagatcac ttagatctcc aacagaggac aaggccttgg ctgtcttcta caccatcttg 840 actccaatgc tcaaccccat catctacagc ctgagaaaca aggaggtgat gggagccatg 900 aggcgatcaa ttcagagagc ctgctttgta aaaatgtag 939

<210> 240 <211> 312 <212> PRT <213> Canis familiaris <400> 240

Met Glu Asn Tyr Thr Gln Thr Ser Thr Asp Phe Ile Leu Leu Gly Leu 1 5 10 15 Phe Pro Ser Thr Arg Ile Gly Leu Phe Leu Phe Ile Val Ile Val Leu 20 25 30

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Val Phe Leu 35 Met Ala Leu Phe Gly Asn Leu Ser Met Ile Leu Leu Ile 40 45 Phe Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 50 55 60 Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met 65 70 75 80 Ala Tyr Asn Phe Val Phe Gly Asn Lys Ser Ile Ser Phe Ile Gly Cys 85 90 95 Gly Ala Gln Ser Phe Phe Phe Leu Thr Leu Gly Gly Ala Glu Ala Leu 100 105 110 Leu Leu Ile Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro 115 120 125 Leu His Tyr Ser Ile Arg Met Asn Lys Lys Val Cys Met Leu Met Ile 130 135 140 Thr Gly Ser Trp Ile Met Gly Ser Ile Asn Ser Cys Ala His Thr Ala 145 150 155 160 Tyr Ala Phe His Ile Pro Tyr Cys Arg Ser Arg Thr Ile Asn His Phe 165 170 175 Phe Cys Asp Val Pro Ala Met Leu Thr Leu Ala Cys Met Asp Thr Trp 180 185 190 Val Tyr Glu Tyr Thr Val Phe Val Ser Thr Ile Leu Phe Leu Val Phe 195 200 205 Pro Phe Ile Cys Ile Thr Phe Ser Tyr Ile Arg Val Leu Leu Ala Ile 210 215 220 Cys Arg Met Gln Ser Thr Glu Gly Arg Lys Lys Ala Tyr Ser Thr Cys 225 230 235 240

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Ser Thr His Leu Thr 245 Val Thr Tyr Leu Arg 260 Pro Arg Leu Ala Val 275 Phe Tyr Thr Tyr Ser 290 Leu Arg Asn Lys Gln 305 Arg Ala Cys Phe Val 310

Val Thr Phe Tyr 250 Tyr Ser Leu Arg 265 Ser Pro Ile Leu 280 Thr Pro Met Glu 295 Val Met Gly Ala Lys Met

Val Pro Phe Ala 255 Tyr Thr Glu Asp 270 Lys Ala Leu Asn 285 Pro Ile Ile Met Arg Arg Ser Ile

300 <210> 241 <211> 954 <212> DNA <213> Canis familiaris <400> 241 atggagctgg gcaactattc acccgttttc cctggcttct agcaacacca tcatgatcat tacttgctca gccagctctc atgctggttg accagatagt cacttcattt acttgacctt gaccgctatg tagccatctg tgcttgttaa ttgtggtggc ccagtgacca tgcagttccc gtccctgctc ttctgaagct gtctgctgca tcatgatgct attctcatca ctgtttatag tgctcctcac acatggtggt catgtatgct gactttgttc ctctgccctc atcctcttgg tctcatccac atggactccc ccttatggat atcttgtaca gggccagagg gccatatcct ggcaggggct gagtttttcc caaccctctg cgctaccctg agcctggctg ggagggtcca tttctgtgcc tctcgagaaa ctcctgtact gacacatcaa cctcatccct ttctctgtca aatgaatgaa gcagaaggaa tgtcagcctc ttttatggtg Page 265 tcctgggctt gttcagcaac tctttgtcat ctccatagcc acctccacac ccccatgtac tttctaccat tgtgccaaag ttgcaggatg cacttcccag tcttaggatt aatgtcctat tccttatgag tcgaaaggtc tagatggctt cctgctcact tcaatcactt cttctgtgag cctatgaaac agccatgtat tctcagcctc ttatacaagg ggcgaaaggc ggtggccact ctgccatgta cacctatgtg

120

180

240

300

360

420

480

540

600

660

720

780

069269_0225_SL.TXT ttgcctcact cttaccatac tcctgagaag gacaaggccg tatctgcctt ctacactatc ctcacaccct tgctcaaccc actcatctat agcctcagga acaaggatgt tagcagggct ttaaagaaaa ctctgggcaa gtgtttgtcc tcaggaagtg tatccacctt ctaa

840

900

954 <210> 242 <211> 317 <212> PRT <213> Canis familiaris <400> 242

Met Glu 1 Leu Gly Asn Tyr Ser Met Tyr Ala Asp Phe Val Leu Leu Gly 5 10 15 Leu Phe Ser Asn Thr Arg Phe Pro Trp Leu Leu Ser Ala Leu Ile Leu 20 25 30 Leu Val Phe Val Ile Ser Ile Ala Ser Asn Thr Ile Met Ile Ile Leu 35 40 45 Ile His Met Asp Ser His Leu His Thr Pro Met Tyr Tyr Leu Leu Ser 50 55 60 Gln Leu Ser Leu Met Asp Ile Leu Tyr Ile Ser Thr Ile Val Pro Lys 65 70 75 80 Met Leu Val Asp Gln Ile Val Gly Gln Arg Ala Ile Ser Phe Ala Gly 85 90 95 Cys Thr Ser Gln His Phe Ile Tyr Leu Thr Leu Ala Gly Ala Glu Phe 100 105 110 Phe Leu Leu Gly Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Leu Met Ser Arg Lys Val Cys Leu Leu Ile 130 135 140 Val Val Ala Ala Trp Leu Gly Gly Ser Ile Asp Gly Phe Leu Leu Thr 145 150 155 160

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Pro Val Thr Met Gln Phe Pro Phe Cys Ala Ser Arg Glu Ile Asn His 165 170 175 Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Thr Asp Thr 180 185 190 Ser Thr Tyr Glu Thr Ala Met Tyr Val Cys Cys Ile Met Met Leu Leu 195 200 205 Ile Pro Phe Ser Val Ile Ser Ala Ser Tyr Thr Arg Ile Leu Ile Thr 210 215 220 Val Tyr Arg Met Asn Glu Ala Glu Gly Arg Arg Lys Ala Val Ala Thr 225 230 235 240 Cys Ser Ser His Met Val Val Val Ser Leu Phe Tyr Gly Ala Ala Met 245 250 255 Tyr Thr Tyr Val Leu Pro His Ser Tyr His Thr Pro Glu Lys Asp Lys 260 265 270 Ala Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Leu Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Ser Arg Ala Leu Lys Lys Thr 290 295 300 Leu Gly Lys Cys Leu Ser Ser Gly Ser Val Ser Thr Phe

305 310 315 <210> 243 <211> 975 <212> DNA <213> Canis familiaris <400> 243 atgagcatgg aggccattct ccagaactcc actgatttta tccttctggg ccttatcacc catcctgcat ttcctgggat tatctttgca gtggttttct ccattttttt ggtggctgtc

120

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acagccaatg tggtcatgat tctactcatc catgttaact ctcggctcca tacacccatg 180 tactttttac tcagccagct ttccatcatg gacactgttt acatttgcat cactgttccc 240 aagatgcttc aagaccttct gtccaaggaa aagatgatct ccttcttggg atgttccctt 300 cagatcttcc tctacctgac tctaattgga ggtgaatttt tcctgctagg cctcatggcc 360 tatgaccggt atgtagctgt gtgcaaaccc ctgcgatacc ctctcctcat gaaccgcaga 420 atttgcttat tcatggtggt gggttcctgg gttggtgggt ccttagatgg attcatgctg 480 acacccttta ctatgagttt cccctactgt gggtcccgag aaatcaatca ctttttctgt 540 gaaatcccag cagtactgaa actgtcatgt gttgacacat cactctatga gactctgatg 600 tatgcctgct gtgtgctaat gctgctcatt cccatatcca ttatctctat ttcctacaca 660 cacatcctac tcactgtcca tcgaatgaac tctgctgagg gccggcataa agcctttgct 720 acctgttctt cccacattat ggtggtgagc attttctatg gagcagcctt ctacactaat 780 gtgctgcccc attcctacca cacaccagag aaagacaagg ttgtatccgc cttctatacc 840 atcctcaccc caatgctcaa cccactcatc tacagcttga gaaacaaaga tgtggccaca 900 gctctaagaa aagtgctggg gagatgcccc tcttctcaga gaataagagt ggtggatttg 960 tccaggaaat actag 975

<210> 244 <211> 324 <212> PRT <213> Canis familiaris <400> 244

Met Ser Met Glu Ala Ile Leu Gln Asn Ser Thr Asp Phe Ile Leu Leu 1 5 10 15 Gly Leu Ile Thr His Pro Ala Phe Pro Gly Ile Ile Phe Ala Val Val 20 25 30 Phe Ser Ile Phe Leu Val Ala Val Thr Ala Asn Val Val Met Ile Leu 35 40 45 Leu Ile His Val Asn Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu 50 55 60

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Ser 65 Gln Leu Ser Ile Met 70 Asp Thr Val Tyr Ile Cys Ile Thr Val Pro 75 80 Lys Met Leu Gln Asp Leu Leu Ser Lys Glu Lys Met Ile Ser Phe Leu 85 90 95 Gly Cys Ser Leu Gln Ile Phe Leu Tyr Leu Thr Leu Ile Gly Gly Glu 100 105 110 Phe Phe Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys 115 120 125 Lys Pro Leu Arg Tyr Pro Leu Leu Met Asn Arg Arg Ile Cys Leu Phe 130 135 140 Met Val Val Gly Ser Trp Val Gly Gly Ser Leu Asp Gly Phe Met Leu 145 150 155 160 Thr Pro Phe Thr Met Ser Phe Pro Tyr Cys Gly Ser Arg Glu Ile Asn 165 170 175 His Phe Phe Cys Glu Ile Pro Ala Val Leu Lys Leu Ser Cys Val Asp 180 185 190 Thr Ser Leu Tyr Glu Thr Leu Met Tyr Ala Cys Cys Val Leu Met Leu 195 200 205 Leu Ile Pro Ile Ser Ile Ile Ser Ile Ser Tyr Thr His Ile Leu Leu 210 215 220 Thr Val His Arg Met Asn Ser Ala Glu Gly Arg His Lys Ala Phe Ala 225 230 235 240 Thr Cys Ser Ser His Ile Met Val Val Ser Ile Phe Tyr Gly Ala Ala 245 250 255 Phe Tyr Thr Asn Val Leu Pro His Ser Tyr His Thr Pro Glu Lys Asp 260 265 270

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Lys Val Val 275 Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Ala Thr Ala Leu Arg Lys 290 295 300 Val Leu Gly Arg Cys Pro Ser Ser Gln Arg Ile Arg Val Val Asp Leu 305 310 315 320

Ser Arg Lys Tyr <210> 245 <211> 960 <212> DNA <213> Canis familiaris <400> 245

atgtcaatga agaatataac tttatcctct gactttatcc tcctggggct tctggtgaac 60 aataaagcta cagggatcgt ttttgctgtt atttttgcta ttttcatggt ggctgtaact 120 gcaaatctgg tcatgatatt cttgattcaa atggactctc gtctccatac acctatgtat 180 ttcctgctca gccagctgtc catcatggac acctttttca tttgtaccac tgtcccaaaa 240 cttctggttg acatggtttc taaagagaag accatttcct ttgtaggttg tggtatccag 300 atcttcctct acttgaccat gattggctca gagttctttc tcttaggcct catggcctat 360 gaccgctacg tggctgtctg taaccctctt aggtatccag tcctgatgaa ccgcagggtg 420 tgtctcctgc tggctgctgg tgcctggttt ggtgggtccc tggatggctt tctgctcacc 480 cccatcacca tgaatgtccc ttactgtggc tcccacagta tcaaccattt tttctgtgag 540 atccctgcag ttctcagact agcctgtgct gacacatcct tgtatgaaac cctaatgtac 600 atctgctgtg tactcatgtt actcatccct atctctatca tctcaacctc ctactctctc 660 atcttgttaa ctgtccaccg aatgcgctct gctgaaggcc ggaaaaaagc tttcaccact 720 tgcttttccc acttaaccgt agtcagcatt ttctatggag ctgccttcta cacttatgtt 780 ctaccccagt cctttcacac tcctgagcag gacaaggtag tgtcagcctt atataccatt 840 gtcaccccca tgctcaatcc tcttatctac agcctcagaa acaaggatgt catgggggca 900

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069269_0225_SL.TXT tttaaaaaga tgtttttgca atactcatct gctcaaaaaa tagcctcaag tgatgtttaa

960 <210> 246 <211> 319 <212> PRT <213> Canis familiaris <400> 246

Met Ser 1 Met Lys Asn Ile Thr Leu Ser Ser Asp Phe Ile Leu Leu Gly 5 10 15 Leu Leu Val Asn Asn Lys Ala Thr Gly Ile Val Phe Ala Val Ile Phe 20 25 30 Ala Ile Phe Met Val Ala Val Thr Ala Asn Leu Val Met Ile Phe Leu 35 40 45 Ile Gln Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Ile Met Asp Thr Phe Phe Ile Cys Thr Thr Val Pro Lys 65 70 75 80 Leu Leu Val Asp Met Val Ser Lys Glu Lys Thr Ile Ser Phe Val Gly 85 90 95 Cys Gly Ile Gln Ile Phe Leu Tyr Leu Thr Met Ile Gly Ser Glu Phe 100 105 110 Phe Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Leu Met Asn Arg Arg Val Cys Leu Leu Leu 130 135 140 Ala Ala Gly Ala Trp Phe Gly Gly Ser Leu Asp Gly Phe Leu Leu Thr 145 150 155 160 Pro Ile Thr Met Asn Val Pro Tyr Cys Gly Ser His Ser Ile Asn His 165 170 175

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Phe Phe Cys Glu 180 Ile Pro Ala Val Leu Arg Leu Ala Cys Ala Asp Thr 185 190 Ser Leu Tyr Glu Thr Leu Met Tyr Ile Cys Cys Val Leu Met Leu Leu 195 200 205 Ile Pro Ile Ser Ile Ile Ser Thr Ser Tyr Ser Leu Ile Leu Leu Thr 210 215 220 Val His Arg Met Arg Ser Ala Glu Gly Arg Lys Lys Ala Phe Thr Thr 225 230 235 240 Cys Phe Ser His Leu Thr Val Val Ser Ile Phe Tyr Gly Ala Ala Phe 245 250 255 Tyr Thr Tyr Val Leu Pro Gln Ser Phe His Thr Pro Glu Gln Asp Lys 260 265 270 Val Val Ser Ala Leu Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Met Gly Ala Phe Lys Lys Met 290 295 300 Phe Leu Gln Tyr Ser Ser Ala Gln Lys Ile Ala Ser Ser Asp Val 305 310 315

<210> 247 <211> 963 <212> DNA <213> Canis familiaris <400> 247 atggagaaca ctacttggat ggccaactat actgtacgat cagattttga actagtggga ctcttcagtc aatccaaaca cccagctgtc ctttgtgtgg tcattttcct ggctttcctg atggccctct ctggaaacac catcctgatc cttctgatac actgtgatgc tcacctccac acccccatgt acttttttat cacccagttg tctctcatgg acgtgatgta catttctgtc

120

180

240

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actgtgccca agatgctcat ggaccaggtc atgggtgtga ataagatctc agcccctgaa 300 tgtgggatgc agatgttttt ctatttgaca ctaggaggtt cagaattttt tcttctagct 360 gccatggcct atgaccgcta tgtggccatc tgccatccac tccgttatcc tatcctcatg 420 aaccatagag tgtgtcttct cttggtgtct tcctcctgga ttttgggatc tgtagatgga 480 tttatgctca ctcctgtcac catgaccttc cccttctgca gatcccgaga gattcaccat 540 ttcttctgtg aggttcctgc tgtaatgaag ctctcctgct cagacacttc cctctatgag 600 acactcatgt acctgtgctg tgtcctcatg ctcttcatca ctgtgacagt cattttaagc 660 tcctattctt tcatcctctt taccatccac aggatgaact cagcagaggg acggaagaag 720 gcttttgcca cttgttcttc ccacatgatg gtggttatct ccttctatgg tgcttctgtc 780 tacacctaca tgctccccac ctcctatcac acccctgaga aggacatgat tgtatctgtc 840 ttttacacca tactcactcc tgttctaaat cctttaattt atagtcttag aaataaggat 900 gtcacaaggg gtctaaaaaa aatgttgaat gtgggatctg tctttcagga aactctaaag 960

taa 963 <210> 248 <211> 320 <212> PRT <213> Canis familiaris <400> 248

Met Glu Asn Thr Thr Trp Met Ala Asn Tyr Thr Val Arg Ser Asp Phe 1 5 10 15 Glu Leu Val Gly Leu Phe Ser Gln Ser Lys His Pro Ala Val Leu Cys 20 25 30 Val Val Ile Phe Leu Ala Phe Leu Met Ala Leu Ser Gly Asn Thr Ile 35 40 45 Leu Ile Leu Leu Ile His Cys Asp Ala His Leu His Thr Pro Met Tyr 50 55 60 Phe Phe Ile Thr Gln Leu Ser Leu Met Asp Val Met Tyr Ile Ser Val 65 70 75 80

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Thr Val Pro Lys Met 85 Leu Met Asp Gln Val Met Gly Val Asn Lys Ile 90 95 Ser Ala Pro Glu Cys Gly Met Gln Met Phe Phe Tyr Leu Thr Leu Gly 100 105 110 Gly Ser Glu Phe Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Ile Leu Met Asn His Arg Val 130 135 140 Cys Leu Leu Leu Val Ser Ser Ser Trp Ile Leu Gly Ser Val Asp Gly 145 150 155 160 Phe Met Leu Thr Pro Val Thr Met Thr Phe Pro Phe Cys Arg Ser Arg 165 170 175 Glu Ile His His Phe Phe Cys Glu Val Pro Ala Val Met Lys Leu Ser 180 185 190 Cys Ser Asp Thr Ser Leu Tyr Glu Thr Leu Met Tyr Leu Cys Cys Val 195 200 205 Leu Met Leu Phe Ile Thr Val Thr Val Ile Leu Ser Ser Tyr Ser Phe 210 215 220 Ile Leu Phe Thr Ile His Arg Met Asn Ser Ala Glu Gly Arg Lys Lys 225 230 235 240 Ala Phe Ala Thr Cys Ser Ser His Met Met Val Val Ile Ser Phe Tyr 245 250 255 Gly Ala Ser Val Tyr Thr Tyr Met Leu Pro Thr Ser Tyr His Thr Pro 260 265 270 Glu Lys Asp Met Ile Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Val 275 280 285

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Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Arg Gly 290 295 300 Leu Lys Lys Met Leu Asn Val Gly Ser Val Phe Gln Glu Thr Leu Lys

305 310 315 320 <210> 249 <211> 963 <212> DNA <213> Canis familiaris <400> 249

atggagaaca tcatgtgggt gaccaactat actgaacgat cagattttga actagtggga 60 ctcttcagtc aatccaagca cccaactctc ctctgtgtgg tcattttcgt ggttttcctg 120 atggccctct ctggaaacac catcctgatc cttctgatac actgtgatgc tcacctccac 180 acccccatgt acttttttat cacccagttg tctctcatgg acgtgatgta catttctgtt 240 actgtgccca agatgctcat ggaccaggtc atgggtgtga ataagatctc agtccctgaa 300 tgcgggatgc agatgtttct ctacttaact ctagtaggct cagaattctt ccttctggct 360 gccatggcct atgaccgcta tgtggccatc tgccatccac tccgttatcc tatcctcatg 420 aaccatagag tgtgtcttct cttggtgtct tcctcctgga ttttgggatc tgtggatgga 480 tttatgctga ctcccgtcac catgaccttc cccttctgca gatcccggga gattcaccat 540 ttcttctgtg aggttcctgc tgtaatgaag ctctcctgct cagacacttc cctctatgag 600 acactcatgt acctgtgctg tgtcctcatg cttctcatcc ctgtgacagt catttcaagc 660 tcctattctt tcatcctctt caccatccac aggatgaact cagcagaggg acggaagaag 720 gcttttgcca cttgttcttc ccacatgatg gtggtcatcc tcttctatgg tgctgccgtc 780 tacacctaca tgctccccac ctcctatcac acccctgaga aggacatgat tgtatctgtc 840 ttttacacca tactcactcc tgttctaaat cctttaattt atagtcttag aaataaggat 900 gtcacaaggg ctcttaaaaa aatgttgaat gtggtatctg tcttacagga acctataaaa 960

tag 963 <210> 250 <211> 320

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069269_0225_SL.TXT <212> PRT <213> Canis familiaris <400> 250

Met Glu Asn Ile Met Trp Val Thr Asn Tyr Thr Glu Arg Ser Asp Phe 1 5 10 15 Glu Leu Val Gly Leu Phe Ser Gln Ser Lys His Pro Thr Leu Leu Cys 20 25 30 Val Val Ile Phe Val Val Phe Leu Met Ala Leu Ser Gly Asn Thr Ile 35 40 45 Leu Ile Leu Leu Ile His Cys Asp Ala His Leu His Thr Pro Met Tyr 50 55 60 Phe Phe Ile Thr Gln Leu Ser Leu Met Asp Val Met Tyr Ile Ser Val 65 70 75 80 Thr Val Pro Lys Met Leu Met Asp Gln Val Met Gly Val Asn Lys Ile 85 90 95 Ser Val Pro Glu Cys Gly Met Gln Met Phe Leu Tyr Leu Thr Leu Val 100 105 110 Gly Ser Glu Phe Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Ile Leu Met Asn His Arg Val 130 135 140 Cys Leu Leu Leu Val Ser Ser Ser Trp Ile Leu Gly Ser Val Asp Gly 145 150 155 160 Phe Met Leu Thr Pro Val Thr Met Thr Phe Pro Phe Cys Arg Ser Arg 165 170 175 Glu Ile His His Phe Phe Cys Glu Val Pro Ala Val Met Lys Leu Ser 180 185 190

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Cys Ser Asp 195 Thr Ser Leu Tyr 069269_0225_SL.TXT Glu Thr Leu Met Tyr Leu 200 205 Cys Cys Val Leu Met Leu Leu Ile Pro Val Thr Val Ile Ser Ser Ser Tyr Ser Phe 210 215 220 Ile Leu Phe Thr Ile His Arg Met Asn Ser Ala Glu Gly Arg Lys Lys 225 230 235 240 Ala Phe Ala Thr Cys Ser Ser His Met Met Val Val Ile Leu Phe Tyr 245 250 255 Gly Ala Ala Val Tyr Thr Tyr Met Leu Pro Thr Ser Tyr His Thr Pro 260 265 270 Glu Lys Asp Met Ile Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Val 275 280 285 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Arg Ala 290 295 300 Leu Lys Lys Met Leu Asn Val Val Ser Val Leu Gln Glu Pro Ile Lys 305 310 315 320

<210> 251 <211> 945 <212> DNA <213> Canis familiaris <400> 251 atggacaatc tcacagaagt gacagagttc ctgctcatgg ggttttctga catctgcgag ctacagatac ttcatgctgg actctttctg ctgatttatc tgacagcagt ggtgtggaac gttctcatca tgattatcat tacttttgat cagtatcttc accggcctat gtacttcttt ctgaagaacc tctccttttt agatttgtgc tatgtttcag tcactgtgcc taagtcaatc cacagctccc tgactcacag taactccatc tcttaccttg gctgtgtggc tcaagtctat tttttctttg cttttgcatc tgctgagctg gcctttctca ctgtcatgtc ctatgatcgc tatgttgcca tttgccaccc cctccaatat gaagccatta tgacatcaga aaaatgccac

120

180

240

300

360

420

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cacatagcag ccattgcctg gctgagttgc tttatttatg catctgtcca cactggcaac 480 atattttggg agcccatatc aagatacaga aaaatccacc agttcttctg tgacatctcc 540 cacgttttgg ccctggtttc ccatgaggtt ttctttgctg agtttgtgag cctggctctg 600 agctcctgct ttgtgctggt ttgctttgtt cttatgatca tctcctatat ccagatcttc 660 tcaacagtgc tcagaatccc ttcagtagag agtagggcaa aagcgttttc tacctgctct 720 ccacagctga ttgttattat gctcttcctt actacagggc tctttggtgc cttgggacca 780 attgccaaga cttcatccat tcaagatttg gtgattgctg tggcttacac agttttgcct 840 cccttcctaa atcccatcat atatagtctt cgaaacaagg agattaaagc agctatttgg 900 aggatatttg agaagataaa ttctttgcaa attagaaaca attag 945

<210> 252 <211> 314 <212> PRT <213> Canis familiaris <400> 252

Met Asp Asn Leu Thr Glu Val Thr Glu Phe Leu Leu Met Gly Phe Ser 1 5 10 15 Asp Ile Cys Glu Leu Gln Ile Leu His Ala Gly Leu Phe Leu Leu Ile 20 25 30 Tyr Leu Thr Ala Val Val Trp Asn Val Leu Ile Met Ile Ile Ile Thr 35 40 45 Phe Asp Gln Tyr Leu His Arg Pro Met Tyr Phe Phe Leu Lys Asn Leu 50 55 60 Ser Phe Leu Asp Leu Cys Tyr Val Ser Val Thr Val Pro Lys Ser Ile 65 70 75 80 His Ser Ser Leu Thr His Ser Asn Ser Ile Ser Tyr Leu Gly Cys Val 85 90 95 Ala Gln Val Tyr Phe Phe Phe Ala Phe Ala Ser Ala Glu Leu Ala Phe 100 105 110

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Leu Thr Val 115 Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu 120 125 Gln Tyr Glu Ala Ile Met Thr Ser Glu Lys Cys His His Ile Ala Ala 130 135 140 Ile Ala Trp Leu Ser Cys Phe Ile Tyr Ala Ser Val His Thr Gly Asn 145 150 155 160 Ile Phe Trp Glu Pro Ile Ser Arg Tyr Arg Lys Ile His Gln Phe Phe 165 170 175 Cys Asp Ile Ser His Val Leu Ala Leu Val Ser His Glu Val Phe Phe 180 185 190 Ala Glu Phe Val Ser Leu Ala Leu Ser Ser Cys Phe Val Leu Val Cys 195 200 205 Phe Val Leu Met Ile Ile Ser Tyr Ile Gln Ile Phe Ser Thr Val Leu 210 215 220 Arg Ile Pro Ser Val Glu Ser Arg Ala Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Pro Gln Leu Ile Val Ile Met Leu Phe Leu Thr Thr Gly Leu Phe Gly 245 250 255 Ala Leu Gly Pro Ile Ala Lys Thr Ser Ser Ile Gln Asp Leu Val Ile 260 265 270 Ala Val Ala Tyr Thr Val Leu Pro Pro Phe Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Ile Lys Ala Ala Ile Trp Arg Ile Phe Glu 290 295 300 Lys Ile Asn Ser Leu Gln Ile Arg Asn Asn 305 310

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069269_0225_SL.TXT <210> 253 <211> 948 <212> DNA <213> Canis familiaris <400> 253

atggaggaaa gcaacaacag ttctgaaaag ggatttcttc tgctgggatt cgcagatgat 60 ccccaactag aaaggatcct ttttgtcata attttgcttt tctacatctt gaacattctg 120 gggaacactg ccatcatttt ggtgtcttat ttagccccca tactccacac tccaatgtac 180 tttttcctta gcaatctctc ttgtgtggac atctgcttta ccaccagcgt tgccccacag 240 ttgctggtta ccatgaataa aaaagaaaaa aacatgagct atggtggatg tgtggcccag 300 ctctatgtgg ctatggggtt gggatcctct gaatgtattc ttttggcagt catggcttat 360 gatcgatatg ctgctgtctg ccggcctctg caatacataa ctattatgca tcctcagctt 420 tgtgcttccc tggccatcat agcatggctc agtggtctta tcacctcctt aattcaatgc 480 tcccttactg tgcagctgcc cctttgtggt catcgcaaac tggaccacat tgtctgcgag 540 gttcctgtgc tcatcaaact ggcctgtgtg gacacaacaa tcaatgaaat agaactcttt 600 gtggccagtg tgatttttct aattgtccct gtgtcactca tcctagtctc ctatggcttt 660 ataacaaaaa ctgtgctgag gataaaatca gcagcagggc gccggaaggc ctttgggact 720 tgttcttccc acctgattgt ggtcatcatt ttttatggaa ccatcatctt tatgtacctt 780 cagccagcca aaagtagctc aaaaaaccag ggaaagtttg tttctctttt ctacaccata 840 gtcaccccag tcttaaaccc cattatctat actctgagaa acaaagatgt gaaaggggcc 900 ttgagaacac tggtgatgag aaatgtttta gtttcaaaaa atacatga 948

<210> 254 <211> 315 <212> PRT <213> Canis familiaris <400> 254

Met Glu Glu Ser Asn Asn Ser Ser Glu Lys Gly Phe Leu Leu Leu Gly 1 5 10 15 Phe Ala Asp Asp Pro Gln Leu Glu Arg Ile Leu Phe Val Ile Ile Leu 20 25 30

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Leu Phe Tyr 35 Ile Leu Asn Ile Leu Gly Asn Thr Ala Ile Ile Leu Val 40 45 Ser Tyr Leu Ala Pro Ile Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Cys Val Asp Ile Cys Phe Thr Thr Ser Val Ala Pro Gln 65 70 75 80 Leu Leu Val Thr Met Asn Lys Lys Glu Lys Asn Met Ser Tyr Gly Gly 85 90 95 Cys Val Ala Gln Leu Tyr Val Ala Met Gly Leu Gly Ser Ser Glu Cys 100 105 110 Ile Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Arg 115 120 125 Pro Leu Gln Tyr Ile Thr Ile Met His Pro Gln Leu Cys Ala Ser Leu 130 135 140 Ala Ile Ile Ala Trp Leu Ser Gly Leu Ile Thr Ser Leu Ile Gln Cys 145 150 155 160 Ser Leu Thr Val Gln Leu Pro Leu Cys Gly His Arg Lys Leu Asp His 165 170 175 Ile Val Cys Glu Val Pro Val Leu Ile Lys Leu Ala Cys Val Asp Thr 180 185 190 Thr Ile Asn Glu Ile Glu Leu Phe Val Ala Ser Val Ile Phe Leu Ile 195 200 205 Val Pro Val Ser Leu Ile Leu Val Ser Tyr Gly Phe Ile Thr Lys Thr 210 215 220 Val Leu Arg Ile Lys Ser Ala Ala Gly Arg Arg Lys Ala Phe Gly Thr 225 230 235 240

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Cys Ser Ser His Leu Ile Val Val Ile Ile Phe Tyr Gly Thr Ile Ile 245 250 255 Phe Met Tyr Leu Gln Pro Ala Lys Ser Ser Ser Lys Asn Gln Gly Lys 260 265 270 Phe Val Ser Leu Phe Tyr Thr Ile Val Thr Pro Val Leu Asn Pro Ile 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Thr Leu 290 295 300 Val Met Arg Asn Val Leu Val Ser Lys Asn Thr 305 310 315

<210> 255 <211> 957 <212> DNA <213> Canis familiaris <400> 255

atgccaaaag cactaggaat tacaaacaac agtttccaag ttggctttat acttctgggc 60 ttctctgaat ggccccatct agaaatgatt ctcttctgga ttgtgatcat cttgtacacc 120 atgatcatcc tctccaactc aaccattatc ttgctctctt atgtggaccc tcatctctac 180 acccccatgt acttctttct tagcaatctt tctttcttgg atctctgctt cactacaact 240 gctgtgcccc agatgttgta caatttgtgg gggccagaca agagcatcac ctacacaggc 300 tgtgtcatcc aactctctgt gttgctctgt cttggtgcca cagaaggtgt catgttggtg 360 gtgatggcat ttgaccgcta tgtagctatt tgtcagcccc tgcactatac aatcatcatg 420 catcatcagt tctgttggaa gctggtgctc atagcctgga tgtctggatt gatggaatct 480 gtgacccaat cccccatcac attccaactt cctttataca cccaccacca tttggatgat 540 tttatttgtg aagttcctgc tttcatacgc ctggcatgtg gaaatacctc tgccattgaa 600 tggcaaatga ccatctctgc tgaccttttc accattgtgc caatggggtt aatcctgact 660 tcttatggct acatagctca agccttaggt aaaatccaat ccaaggatgg aaggcagaag 720

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069269_0225_SL.TXT gccattgcca cctgttcttc tcatctcact gtggtcctca tgttttatgg gacagtggcc atggtttata cagaccctaa gaatgacttt gcttcaaatt atggcaagtt attcactttc ttctacactt tagtcacacc attgttgaac cctctcatct ataccctaag gaacaaagaa gtgaaggatg ctctgcaaag actcctgaag aagtggatgt gtaaatggaa aaagtag

780

840

900

957 <210> 256 <211> 318 <212> PRT <213> Canis familiaris <400> 256

Met Pro Lys Ala Leu Gly Ile Thr Asn Asn Ser Phe Gln Val Gly Phe 1 5 10 15 Ile Leu Leu Gly Phe Ser Glu Trp Pro His Leu Glu Met Ile Leu Phe 20 25 30 Trp Ile Val Ile Ile Leu Tyr Thr Met Ile Ile Leu Ser Asn Ser Thr 35 40 45 Ile Ile Leu Leu Ser Tyr Val Asp Pro His Leu Tyr Thr Pro Met Tyr 50 55 60 Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Leu Cys Phe Thr Thr Thr 65 70 75 80 Ala Val Pro Gln Met Leu Tyr Asn Leu Trp Gly Pro Asp Lys Ser Ile 85 90 95 Thr Tyr Thr Gly Cys Val Ile Gln Leu Ser Val Leu Leu Cys Leu Gly 100 105 110 Ala Thr Glu Gly Val Met Leu Val Val Met Ala Phe Asp Arg Tyr Val 115 120 125 Ala Ile Cys Gln Pro Leu His Tyr Thr Ile Ile Met His His Gln Phe 130 135 140 Cys Trp Lys Leu Val Leu Ile Ala Trp Met Ser Gly Leu Met Glu Ser

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145 150 155 160 Val Thr Gln Ser Pro Ile Thr Phe Gln Leu Pro Leu Tyr Thr His His 165 170 175 His Leu Asp Asp Phe Ile Cys Glu Val Pro Ala Phe Ile Arg Leu Ala 180 185 190 Cys Gly Asn Thr Ser Ala Ile Glu Trp Gln Met Thr Ile Ser Ala Asp 195 200 205 Leu Phe Thr Ile Val Pro Met Gly Leu Ile Leu Thr Ser Tyr Gly Tyr 210 215 220 Ile Ala Gln Ala Leu Gly Lys Ile Gln Ser Lys Asp Gly Arg Gln Lys 225 230 235 240 Ala Ile Ala Thr Cys Ser Ser His Leu Thr Val Val Leu Met Phe Tyr 245 250 255 Gly Thr Val Ala Met Val Tyr Thr Asp Pro Lys Asn Asp Phe Ala Ser 260 265 270 Asn Tyr Gly Lys Leu Phe Thr Phe Phe Tyr Thr Leu Val Thr Pro Leu 275 280 285 Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Asp Ala 290 295 300 Leu Gln Arg Leu Leu Lys Lys Trp Met Cys Lys Trp Lys Lys

305 310 315 <210> 257 <211> 945 <212> DNA <213> Canis familiaris <400> 257 atgccaaaag taccagtgat gaccaacaag agtttcccaa tgggcttcat tcttctgggc 60 ttctctgaat ggccccatct agaaatgatt ctcttctgga ttgtgatcat cttgtacacc 120

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atgatcatcc tctccaactc aataattatc ttactctctt gtgtggaccc tcatctctac 180 acccccatgt acttctttct tagcaatctt tctttcttgg atctctgctt taccacaacc 240 actgtgcccc atatgttgtc caacttgtgg gggccaggca agatcatcac ccacacaggc 300 tgtgtcatcc aactctgtat gttgctctgc cttggtgcca cagaatgtgt catgttggta 360 gtgatggcct ttgaccgcta cattgctatc tgccagccct tgcactatac catcatcatg 420 catcatcagt tctgttggaa gctggtgctc atagcctggc tctctggcct gatagaatct 480 gttactcaaa ttcctgtcac acttcagctt ccattctgca cccaccaccg cctagatgac 540 tttctgtgtg aggttccagc cctcatacgg ttgacatgtg gagacacctc tgccattgaa 600 tggcaaatga ccatctctgc tattcttttc accatcgtgc cactggcatt gatcctgact 660 tcttatggct acatagctca agctttaggt aaaatccaat ccaaagatgg aaggcagaaa 720 gccattgcca catgttcctc ccaccttact gtggtattca tgttttacgg aactgtggca 780 ccagtgtata catatcctaa gaatcacttt gcttcaacat atagcaaatt ctttaccttc 840 ttctacactg tggtcacacc attgttaaat cctcttatct attccctgag gaacaaagac 900 gtaaagaatg ctatgctaca actgctgaga agaggatcac catga 945

<210> 258 <211> 314 <212> PRT <213> Canis familiaris <400> 258

Met Pro Lys Val Pro Val Met Thr Asn Lys Ser Phe Pro Met Gly Phe 1 5 10 15 Ile Leu Leu Gly Phe Ser Glu Trp Pro His Leu Glu Met Ile Leu Phe 20 25 30 Trp Ile Val Ile Ile Leu Tyr Thr Met Ile Ile Leu Ser Asn Ser Ile 35 40 45 Ile Ile Leu Leu Ser Cys Val Asp Pro His Leu Tyr Thr Pro Met Tyr 50 55 60

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Phe 65 Phe Leu Ser Asn Leu 70 Ser Phe Leu Asp Leu Cys Phe Thr Thr Thr 75 80 Thr Val Pro His Met Leu Ser Asn Leu Trp Gly Pro Gly Lys Ile Ile 85 90 95 Thr His Thr Gly Cys Val Ile Gln Leu Cys Met Leu Leu Cys Leu Gly 100 105 110 Ala Thr Glu Cys Val Met Leu Val Val Met Ala Phe Asp Arg Tyr Ile 115 120 125 Ala Ile Cys Gln Pro Leu His Tyr Thr Ile Ile Met His His Gln Phe 130 135 140 Cys Trp Lys Leu Val Leu Ile Ala Trp Leu Ser Gly Leu Ile Glu Ser 145 150 155 160 Val Thr Gln Ile Pro Val Thr Leu Gln Leu Pro Phe Cys Thr His His 165 170 175 Arg Leu Asp Asp Phe Leu Cys Glu Val Pro Ala Leu Ile Arg Leu Thr 180 185 190 Cys Gly Asp Thr Ser Ala Ile Glu Trp Gln Met Thr Ile Ser Ala Ile 195 200 205 Leu Phe Thr Ile Val Pro Leu Ala Leu Ile Leu Thr Ser Tyr Gly Tyr 210 215 220 Ile Ala Gln Ala Leu Gly Lys Ile Gln Ser Lys Asp Gly Arg Gln Lys 225 230 235 240 Ala Ile Ala Thr Cys Ser Ser His Leu Thr Val Val Phe Met Phe Tyr 245 250 255 Gly Thr Val Ala Pro Val Tyr Thr Tyr Pro Lys Asn His Phe Ala Ser 260 265 270

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Thr Tyr Ser Lys Phe Phe Thr Phe Phe Tyr 280 Thr Val Val 285 Thr Pro Leu 275 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala 290 295 300 Met Leu Gln Leu Leu Arg Arg Gly Ser Pro 305 310

<210> 259 <211> 936 <212> DNA <213> Canis familiaris <400> 259

atggaaaatt ttaaccagac atctggtttc ttcttattgg ggctgtttcc accatcaaga 60 attggcctgt gctttttcat tctcattgtt cttattttcc taatggctgt gtttggcaac 120 ctgtccatga tcatcctcat ctttgtggac actcatctcc acacacccat gtattttcta 180 cttagtcagc tctccctcat ggacctgagc tacatctcca atattgtccc caagatggct 240 tctaattatc tctctggaaa caagtctatt tctttcatta agtgtggagt tcagagcttc 300 ttcttcattg ctttagctgg tgcagaagga ctaatattgg cctcgatggc ttatgatcgt 360 tatgtggcta tttgctttcc tcttcactat cccattcgta taagcaaaaa agtgtgcgtg 420 ctgatgataa cgggatcttg gatagtgggc tcagtcaact cctgtgccca cactgtatat 480 gccttcaata taccttactg tcaatccagg actatcaatc acttcttctg tgaagtccca 540 gccatgttga cgctggcctg catggatacc tgggtctatg agtacacggt gtttgtgagc 600 accacactct tgattgtaat tcctttcatt ggcattgcat gttcctatgg acgtgttctc 660 cttgccatct tccacatgca gtccacagaa gggaagaaga aggcctattc cacctgcagc 720 acccacctca ctgtggtgac tttctactat gcaccctttg cttacactta tttacgccca 780 agatccctcc gaactccaac agaggacaag gccttggctg tattctacac catcttgacc 840 ccaatgctta acccaattgt ttacagcctg agaaataagg aagtgatggg tgctctgaga 900 agagtgattc tgaagttctg ctctatagaa atgtag 936

<210> 260

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069269_0225_SL.TXT <211> 311 <212> PRT <213> Canis familiaris <400> 260

Met Glu Asn Phe Asn Gln Thr Ser Gly Phe Phe Leu Leu Gly Leu Phe 1 5 10 15 Pro Pro Ser Arg Ile Gly Leu Cys Phe Phe Ile Leu Ile Val Leu Ile 20 25 30 Phe Leu Met Ala Val Phe Gly Asn Leu Ser Met Ile Ile Leu Ile Phe 35 40 45 Val Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu 50 55 60 Ser Leu Met Asp Leu Ser Tyr Ile Ser Asn Ile Val Pro Lys Met Ala 65 70 75 80 Ser Asn Tyr Leu Ser Gly Asn Lys Ser Ile Ser Phe Ile Lys Cys Gly 85 90 95 Val Gln Ser Phe Phe Phe Ile Ala Leu Ala Gly Ala Glu Gly Leu Ile 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro Leu 115 120 125 His Tyr Pro Ile Arg Ile Ser Lys Lys Val Cys Val Leu Met Ile Thr 130 135 140 Gly Ser Trp Ile Val Gly Ser Val Asn Ser Cys Ala His Thr Val Tyr 145 150 155 160 Ala Phe Asn Ile Pro Tyr Cys Gln Ser Arg Thr Ile Asn His Phe Phe 165 170 175 Cys Glu Val Pro Ala Met Leu Thr Leu Ala Cys Met Asp Thr Trp Val 180 185 190

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Tyr Glu Tyr Thr Val Phe Val Ser Thr Thr Leu Leu Ile Val Ile Pro 195 200 205 Phe Ile Gly Ile Ala Cys Ser Tyr Gly Arg Val Leu Leu Ala Ile Phe 210 215 220 His Met Gln Ser Thr Glu Gly Lys Lys Lys Ala Tyr Ser Thr Cys Ser 225 230 235 240 Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Ala Tyr Thr 245 250 255 Tyr Leu Arg Pro Arg Ser Leu Arg Thr Pro Thr Glu Asp Lys Ala Leu 260 265 270 Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Arg Arg Val Ile Leu 290 295 300 Lys Phe Cys Ser Ile Glu Met

305 310 <210> 261 <211> 939 <212> DNA <213> Canis familiaris <400> 261

atggaaaact atactcaaac atcaactgat ttcaccctac tgggcttgtt cccaccaaca 60 agaattggcc tgttcctctt tattgtcatc gttctcgttt tcctaatggc tctgtttggc 120 aacctgtcca tgattcttct tatcttcaga gacacacatc tccacacacc catgtatttc 180 ttactcagtc agctctctct cattgaccta agctatatct ccacgattgt ccccaaaatg 240 acctacaatt ttgtgtgtgg aaacaagtct atctccttca ttgggtgtgg agttcagagc 300 tactttttct tgactttagc aggtgcagaa gctttgctcc tgatatctat ggcctatgat 360 cgttatgtgg ctatttgctt tcctcttcac tatcccattc gtatgagcaa aaaagtatgc 420

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atgctgatga taacaggatc ttggataatg ggctcagtca atgcttgtgc ccacactgta 480 tacgccttcc atatacctta ctgtcgatcc aggaacatca accatttctt ctgtgatgtc 540 ccagccatgt tgactttagc ctgcatggac acctgggtct atgagtacac agtgtttgtg 600 agcaccatcc tcttccttgc atttccattc attggcattg tatgttccta tggccgggtc 660 ctcctagcta tctgccacat gcagtccaca gaagggagga agaaggccta ttccacctgc 720 agcacccacc ttactgtagt gactttatac tatgcacctt ttgtttacac atatttatgc 780 ccgagatcct ttcgatctcc aacagagaac aaggtcctag ctgttttcta cactatcctg 840 accccagtgc tcaaccccat aatctactgc ctgagaaaca aggaggtgat gggagccctg 900 agacgattga ttcagagaat ctcctttgtt aaaatgtag 939

<210> 262 <211> 312 <212> PRT <213> Canis familiaris <400> 262

Met Glu Asn Tyr Thr Gln Thr Ser Thr Asp Phe Thr Leu Leu Gly Leu 1 5 10 15 Phe Pro Pro Thr Arg Ile Gly Leu Phe Leu Phe Ile Val Ile Val Leu 20 25 30 Val Phe Leu Met Ala Leu Phe Gly Asn Leu Ser Met Ile Leu Leu Ile 35 40 45 Phe Arg Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 50 55 60 Leu Ser Leu Ile Asp Leu Ser Tyr Ile Ser Thr Ile Val Pro Lys Met 65 70 75 80 Thr Tyr Asn Phe Val Cys Gly Asn Lys Ser Ile Ser Phe Ile Gly Cys 85 90 95 Gly Val Gln Ser Tyr Phe Phe Leu Thr Leu Ala Gly Ala Glu Ala Leu 100 105 110

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Leu Leu Ile 115 Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro 120 125 Leu His Tyr Pro Ile Arg Met Ser Lys Lys Val Cys Met Leu Met Ile 130 135 140 Thr Gly Ser Trp Ile Met Gly Ser Val Asn Ala Cys Ala His Thr Val 145 150 155 160 Tyr Ala Phe His Ile Pro Tyr Cys Arg Ser Arg Asn Ile Asn His Phe 165 170 175 Phe Cys Asp Val Pro Ala Met Leu Thr Leu Ala Cys Met Asp Thr Trp 180 185 190 Val Tyr Glu Tyr Thr Val Phe Val Ser Thr Ile Leu Phe Leu Ala Phe 195 200 205 Pro Phe Ile Gly Ile Val Cys Ser Tyr Gly Arg Val Leu Leu Ala Ile 210 215 220 Cys His Met Gln Ser Thr Glu Gly Arg Lys Lys Ala Tyr Ser Thr Cys 225 230 235 240 Ser Thr His Leu Thr Val Val Thr Leu Tyr Tyr Ala Pro Phe Val Tyr 245 250 255 Thr Tyr Leu Cys Pro Arg Ser Phe Arg Ser Pro Thr Glu Asn Lys Val 260 265 270 Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Val Leu Asn Pro Ile Ile 275 280 285 Tyr Cys Leu Arg Asn Lys Glu Val Met Gly Ala Leu Arg Arg Leu Ile 290 295 300 Gln Arg Ile Ser Phe Val Lys Met

305 310

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069269_0225_SL.TXT <210> 263 <211> 408 <212> DNA <213> Canis familiaris <400> 263

atgatgggac atgagaatca catttttacc agtgacttca ttctcttagg actctttgct 60 tcttcccata caagccaaat tttcttcccc tttatattca tcatttttat ggtgtcttta 120 acagaaaaca caatcatgat cctccttatc ctcagggact cgagactcca tactccaatg 180 tatttcctgc tcagccacct ctctttcatg gacatcttgc atatttccaa cattgttccc 240 aaaatgatca ccaactttct ctcaggcaga actatttcat ttgcaggttg tggcttccag 300 atatttctat ccctcctcct ggatggtgag tgcctcctcc tggcggcaat gtcttatgat 360 cgctatgtag ccatctgtca tgcactgcac tatcccatac ttctatcc 408

<210> 264 <211> 136 <212> PRT <213> Canis familiaris <400> 264

Met Met Gly His Glu Asn His Ile Phe Thr Ser Asp Phe Ile Leu Leu 1 5 10 15 Gly Leu Phe Ala Ser Ser His Thr Ser Gln Ile Phe Phe Pro Phe Ile 20 25 30 Phe Ile Ile Phe Met Val Ser Leu Thr Glu Asn Thr Ile Met Ile Leu 35 40 45 Leu Ile Leu Arg Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu 50 55 60 Ser His Leu Ser Phe Met Asp Ile Leu His Ile Ser Asn Ile Val Pro 65 70 75 80 Lys Met Ile Thr Asn Phe Leu Ser Gly Arg Thr Ile Ser Phe Ala Gly 85 90 95

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Cys Gly Phe Gln Ile Phe Leu Ser Leu Leu Leu Asp Gly Glu Cys Leu 100 105 110 Leu Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Ala 115 120 125 Leu His Tyr Pro Ile Leu Leu Ser 130 135

<210> 265 <211> 945 <212> DNA <213> Canis familiaris <400> 265

atggaaaatg caaatgacac tactgagata aactttattc ttctagggct ctttaaacac 60 actccaatcc atttgttcct cttttccatg gtgctcatgt tcttcctcac ctctctgatg 120 ggcaatgccc tcatgatcat gctcatctat gaggaccccc ggctgcacac gcccatgttc 180 ttcttgctca gccagctttc tgtcatggac atgatgctgg tctccaccat agtccccaaa 240 atggcagcca actacctgat gggcaccggg tccatctctc ctgctggctg tggagcccag 300 atcttcctgt ttctcacact gggagggggt gagtgctttc tcttagcagc catggcctat 360 gatcgctatg tggccatatg tcatcccctg cgctaccaca tcctcatgaa tcagaagctc 420 tgcttgcaca tgaccgcagg ttcctggatt ctgggaggag tagatggact gatgcaggct 480 ggtgtcactc tgagcttcgc ttactgccat tctcgggaaa taaaccactt cttttgtgag 540 gcacccacac ttgtgcgcct tgcctgtgct gacactatgt tttttgagtt gttcatgtat 600 gtatgctgtg ttctgatgct cttgatccca ctgtctctta ttctggcctc ctacagtctc 660 atccttgctg ctgtactccg catgcagtcc acagcagccc aaaagaaagc ctttgccact 720 tgctcctctc acctggctgt tgtggggctt ttctatggtg ccataatatt catctacatg 780 cggcccaaat cctaccattc agtggcctat gacaaggtga tctctgcttt ttataccatc 840 ttcacacctg tgttgaatcc ccttatatac agtgtgagga ataaagaagt caagggggct 900 ttgagaaagt ggctggagaa acattttctg ggacaactac agtga 945

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069269_0225_SL.TXT <210> 266 <211> 314 <212> PRT <213> Canis familiaris <400> 266

Met Glu Asn Ala Asn Asp Thr Thr Glu Ile Asn Phe Ile Leu Leu Gly 1 5 10 15 Leu Phe Lys His Thr Pro Ile His Leu Phe Leu Phe Ser Met Val Leu 20 25 30 Met Phe Phe Leu Thr Ser Leu Met Gly Asn Ala Leu Met Ile Met Leu 35 40 45 Ile Tyr Glu Asp Pro Arg Leu His Thr Pro Met Phe Phe Leu Leu Ser 50 55 60 Gln Leu Ser Val Met Asp Met Met Leu Val Ser Thr Ile Val Pro Lys 65 70 75 80 Met Ala Ala Asn Tyr Leu Met Gly Thr Gly Ser Ile Ser Pro Ala Gly 85 90 95 Cys Gly Ala Gln Ile Phe Leu Phe Leu Thr Leu Gly Gly Gly Glu Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr His Ile Leu Met Asn Gln Lys Leu Cys Leu His Met 130 135 140 Thr Ala Gly Ser Trp Ile Leu Gly Gly Val Asp Gly Leu Met Gln Ala 145 150 155 160 Gly Val Thr Leu Ser Phe Ala Tyr Cys His Ser Arg Glu Ile Asn His 165 170 175 Phe Phe Cys Glu Ala Pro Thr Leu Val Arg Leu Ala Cys Ala Asp Thr 180 185 190

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Met Phe Phe 195 Glu Leu Phe Met Tyr Val Cys Cys Val Leu Met Leu Leu 200 205 Ile Pro Leu Ser Leu Ile Leu Ala Ser Tyr Ser Leu Ile Leu Ala Ala 210 215 220 Val Leu Arg Met Gln Ser Thr Ala Ala Gln Lys Lys Ala Phe Ala Thr 225 230 235 240 Cys Ser Ser His Leu Ala Val Val Gly Leu Phe Tyr Gly Ala Ile Ile 245 250 255 Phe Ile Tyr Met Arg Pro Lys Ser Tyr His Ser Val Ala Tyr Asp Lys 260 265 270 Val Ile Ser Ala Phe Tyr Thr Ile Phe Thr Pro Val Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Val Arg Asn Lys Glu Val Lys Gly Ala Leu Arg Lys Trp 290 295 300 Leu Glu Lys His Phe Leu Gly Gln Leu Gln 305 310

<210> 267 <211> 939 <212> DNA <213> Canis familiaris <400> 267

atgatgggat gtgagaatca aaatttcacc actgatttca ttcttttagg actcttttct 60 tcctcccaat caagtcaaat tttcttttcc tttatattca tcatttttat gatgacttta 120 acagaaaaca caatcatgat ccttcttgtc ctcagggact cgagactcca tactccaatg 180 tatttcctgc tcagccacct ctctttcatg gacatcttgc atatttccaa cattgttccc 240 aaaatgatca tcaactttct ctcaggcagc agaactattt catttgcagg ttgtggcttc 300 caaatatttc tatccctcac cctcctgggt ggtgagtgcc ttctcctggc ggcaatgtct 360

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tatgatcgct atgtagccat ctgtcatcca ctgcactatc acattcttat gaatgactat 420 gtccgcaatc tcatggctgc agggtcctgg attgttggga ccgtcaactc catagctcac 480 acggtttatg ccctgcactt tcctttctgt ggctcgagag ccattgatca ctttttctgt 540 gaagtccctg ccatgttgaa attgtcttgt gaggacacaa cactctatga acaaggagtt 600 tatgtaagtg gtttaatttt tctacttgtc cctttctccc taatctttgt ttcttatgtg 660 caaattcttc ttactgtcct taaaatgaaa tcatcagaag cacgtaaaaa gtcattttct 720 acctgttcct tccacatgat tgtggtcaca atgtactatg ggccatttat tttcacatac 780 atgagaccca aagcatacca cacaccaggc caggacatgt atttggcaat attctacacc 840 atcatcacac ctacactcaa ccctatcatc tacagcttta ggaataaaga tgttctggag 900 gcaatgaaaa atatgttaaa aagtaaattt ctccattaa 939

<210> 268 <211> 312 <212> PRT <213> Canis familiaris <400> 268

Met Met Gly Cys Glu Asn Gln Asn Phe Thr Thr Asp Phe Ile Leu Leu 1 5 10 15 Gly Leu Phe Ser Ser Ser Gln Ser Ser Gln Ile Phe Phe Ser Phe Ile 20 25 30 Phe Ile Ile Phe Met Met Thr Leu Thr Glu Asn Thr Ile Met Ile Leu 35 40 45 Leu Val Leu Arg Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu 50 55 60 Ser His Leu Ser Phe Met Asp Ile Leu His Ile Ser Asn Ile Val Pro 65 70 75 80 Lys Met Ile Ile Asn Phe Leu Ser Gly Ser Arg Thr Ile Ser Phe Ala 85 90 95 Gly Cys Gly Phe Gln Ile Phe Leu Ser Leu Thr Leu Leu Gly Gly Glu

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100

069269_0225_SL.TXT 105 110

Cys Leu Leu Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 His Pro Leu His Tyr His Ile Leu Met Asn Asp Tyr Val Arg Asn Leu 130 135 140 Met Ala Ala Gly Ser Trp Ile Val Gly Thr Val Asn Ser Ile Ala His 145 150 155 160 Thr Val Tyr Ala Leu His Phe Pro Phe Cys Gly Ser Arg Ala Ile Asp 165 170 175 His Phe Phe Cys Glu Val Pro Ala Met Leu Lys Leu Ser Cys Glu Asp 180 185 190 Thr Thr Leu Tyr Glu Gln Gly Val Tyr Val Ser Gly Leu Ile Phe Leu 195 200 205 Leu Val Pro Phe Ser Leu Ile Phe Val Ser Tyr Val Gln Ile Leu Leu 210 215 220 Thr Val Leu Lys Met Lys Ser Ser Glu Ala Arg Lys Lys Ser Phe Ser 225 230 235 240 Thr Cys Ser Phe His Met Ile Val Val Thr Met Tyr Tyr Gly Pro Phe 245 250 255 Ile Phe Thr Tyr Met Arg Pro Lys Ala Tyr His Thr Pro Gly Gln Asp 260 265 270 Met Tyr Leu Ala Ile Phe Tyr Thr Ile Ile Thr Pro Thr Leu Asn Pro 275 280 285 Ile Ile Tyr Ser Phe Arg Asn Lys Asp Val Leu Glu Ala Met Lys Asn 290 295 300 Met Leu Lys Ser Lys Phe Leu His

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305

310 <210> 269 <211> 939 <212> DNA <213> Canis familiaris <400> 269

atgcaggaac tcaaccggtc cagtgtgaca gaatttgttc tgttgggctt cacccccaac 60 cccaggacca accctctgct cttcaccttc tttctcactt tttacctgct aatcctcatg 120 agcaacagcc tcctcatcat cctcatctgc gaggactccc gcctccacac acccatgtac 180 tttttcatca gtgtcctctc catgctggac atgtgctaca cgaccactac tgtgccccag 240 atgctcatgc acattctcag caagaagagg gccatctctt ttgctagatg tgtggcccag 300 atgtacatct tcctcctctt tggtgtcacg gagtcctggc ttttctccat catgtctgtg 360 gacaggtacg tggctatttg ccatcctctc cgatacaagg tcatcatgag ccgctggatg 420 tgtctcctca tggtgggcat ctgtggagtt tatggcgtgg tgggtagcct gtgctacact 480 ttctttgcga tgcgcctgcc ctactgtggc cctaatgaaa ttgaccacta cttctgtgag 540 gtccctgcca tcctgaagct ggcctgtgca gacacatccc tcaatgactt ggtggacttc 600 atcacgggct tcaatgtcat tgtggtccca ctgaccctgg ttgtcattgt ctatgccaac 660 atctttgcca ccatcatgaa gatccactca gcccagggac agatcaaagc cttctccacc 720 tgtgcctccc acatcaccgt ggtcaccatg ttcgctatcc catgcatcat catgtacatg 780 agccctggct ctgactcctt gtcaaacagt ggaaagaaaa tggccctttt ctataacatt 840 gccacagcct tcctcaaccc tgtcatctat agtctgagga acaaggacgt aaaaaaggct 900 ttcctcaaat tgatgggatg gagcagggcc ccagagtga 939

<210> 270 <211> 312 <212> PRT <213> Canis familiaris <400> 270

Met Gln Glu Leu Asn Arg Ser Ser Val Thr Glu Phe Val Leu Leu Gly 1 5 10 15

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Phe Thr Pro Asn 20 Pro Arg Thr Asn Pro Leu Leu Phe Thr Phe Phe Leu 25 30 Thr Phe Tyr Leu Leu Ile Leu Met Ser Asn Ser Leu Leu Ile Ile Leu 35 40 45 Ile Cys Glu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Ile Ser 50 55 60 Val Leu Ser Met Leu Asp Met Cys Tyr Thr Thr Thr Thr Val Pro Gln 65 70 75 80 Met Leu Met His Ile Leu Ser Lys Lys Arg Ala Ile Ser Phe Ala Arg 85 90 95 Cys Val Ala Gln Met Tyr Ile Phe Leu Leu Phe Gly Val Thr Glu Ser 100 105 110 Trp Leu Phe Ser Ile Met Ser Val Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Lys Val Ile Met Ser Arg Trp Met Cys Leu Leu Met 130 135 140 Val Gly Ile Cys Gly Val Tyr Gly Val Val Gly Ser Leu Cys Tyr Thr 145 150 155 160 Phe Phe Ala Met Arg Leu Pro Tyr Cys Gly Pro Asn Glu Ile Asp His 165 170 175 Tyr Phe Cys Glu Val Pro Ala Ile Leu Lys Leu Ala Cys Ala Asp Thr 180 185 190 Ser Leu Asn Asp Leu Val Asp Phe Ile Thr Gly Phe Asn Val Ile Val 195 200 205 Val Pro Leu Thr Leu Val Val Ile Val Tyr Ala Asn Ile Phe Ala Thr 210 215 220

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Ile Met 225 Lys Ile His Ser Ala Gln Gly Gln 230 Ile Lys Ala Phe Ser Thr 235 240 Cys Ala Ser His Ile Thr Val Val Thr Met Phe Ala Ile Pro Cys Ile 245 250 255 Ile Met Tyr Met Ser Pro Gly Ser Asp Ser Leu Ser Asn Ser Gly Lys 260 265 270 Lys Met Ala Leu Phe Tyr Asn Ile Ala Thr Ala Phe Leu Asn Pro Val 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Phe Leu Lys Leu 290 295 300 Met Gly Trp Ser Arg Ala Pro Glu 305 310

<210> 271 <211> 948 <212> DNA <213> Canis familiaris <400> 271

atgcagagcc ttggcaagga gaaccacagc tctgtgtttg agttcatcct cctgggcttc 60 tccagtgact cacaggtcag aatatccctg ttctccttct tccttctcct ctacctcatc 120 actattctgg gaaatggact cattgtgacc ctgatctacc tggactcaca cctccacatg 180 cccatgtact actttctcag tgtcctctct ttggtggaca tgagttatgt cactaccacc 240 atgccccaga tgttgattaa tatggtgtgt ccaaagaaaa ccatctcttg gggagcttgt 300 gtagcccaga tgtttatctt cttggtcttg ggcattgctg agtgcgtcct ctatgccatt 360 atggcctatg acaggtatgt ggccatttgc tttccccttc attatcccct tctcatgagc 420 cgccccattt gtatcaagat ggtcacaggt tgttggacca ttagcatagc tggcgccctg 480 atctacactg tcttcaccat gcatctgcct tattgtggtc cccacaagat aaaccacttc 540 ttctgtgagg tccctgccgt cttgaagttg gcctgtgcag atacatcttt caatgaccgc 600 ttggacttca tcttgggatt catcctactc ttggtcccat tctccctcat cctggcctcc 660

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tctttgcctc catcttaaga atccactcat cccaagggag gctcaagtct 720 gtgcttccca catcactgtg gttatcatgt tctatgggcc agccatgatc 780 ggcctggctc ctggtatgac ccagagcggg acaagaagct agcactgttc 840 tctctgcctt cctcaacccc atcatctaca gcctccggaa caaagatgta 900 ttatgaatgt actcggtaac agaaggacat ctcagtga 948

<210> 272 <211> 315 <212> PRT <213> Canis familiaris <400> 272

Met Gln Ser Leu Gly Lys Glu Asn His Ser Ser Val Phe Glu Phe Ile 1 5 10 15

Leu Leu Gly Phe Ser Ser Asp Ser Gln Val Arg Ile Ser Leu Phe Ser 20 25 30

Phe Phe Leu Leu Leu Tyr Leu Ile Thr Ile Leu Gly Asn Gly Leu Ile 35 40 45

Val Thr Leu Ile Tyr Leu Asp Ser His Leu His Met Pro Met Tyr Tyr 50 55 60

Phe Leu Ser Val Leu Ser Leu Val Asp Met Ser Tyr Val Thr Thr Thr 65 70 75 80

Met Pro Gln Met Leu Ile Asn Met Val Cys Pro Lys Lys Thr Ile Ser 85 90 95

Trp Gly Ala Cys Val Ala Gln Met Phe Ile Phe Leu Val Leu Gly Ile 100 105 110

Ala Glu Cys Val Leu Tyr Ala Ile Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125

Ile Cys Phe Pro Leu His Tyr Pro Leu Leu Met Ser Arg Pro Ile Cys 130 135 140

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Ile Lys Met 145 Val Thr Gly Cys Trp Thr Ile Ser Ile Ala Gly Ala Leu 150 155 160 Ile Tyr Thr Val Phe Thr Met His Leu Pro Tyr Cys Gly Pro His Lys 165 170 175 Ile Asn His Phe Phe Cys Glu Val Pro Ala Val Leu Lys Leu Ala Cys 180 185 190 Ala Asp Thr Ser Phe Asn Asp Arg Leu Asp Phe Ile Leu Gly Phe Ile 195 200 205 Leu Leu Leu Val Pro Phe Ser Leu Ile Leu Ala Ser Tyr Val Arg Ile 210 215 220 Phe Ala Ser Ile Leu Arg Ile His Ser Ser Gln Gly Arg Leu Lys Ser 225 230 235 240 Phe Ser Thr Cys Ala Ser His Ile Thr Val Val Ile Met Phe Tyr Gly 245 250 255 Pro Ala Met Ile Met Tyr Met Arg Pro Gly Ser Trp Tyr Asp Pro Glu 260 265 270 Arg Asp Lys Lys Leu Ala Leu Phe Tyr Asn Val Val Ser Ala Phe Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Phe 290 295 300 Met Asn Val Leu Gly Asn Arg Arg Thr Ser Gln 305 310 315 <210> 273 <211> 942 <212> DNA <213> Canis familiaris <400> 273 atgatggaag agtttaacca gtcctctgtg actgaattca tccttctagg cttctccttc 60

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aaccccagga ccactcctct gctcttcaca gtcttcctga tgacctacct gttgattatt 120 ctgggcaaca gcttaatcac catcctcatc tgcctggact cacacctcca cacacccatg 180 tacttcttta ttggtatcct ttccatattg gatctgggct acaccactac aactgtgccc 240 cagatgctgg cacatttagc cagccagaag aagaccatct cttttgccag ctgtgtggcc 300 caaatgtaca ttttcttggt gctaggcatc actgagtcat ggctctttgc catgatgtct 360 atagacaggt atgtagccat ctgccacccc ctcagataca aggtcatcat gagcccgtgg 420 ctatgtgggg taatggtcat tttctgtgga ctcatgggca taatctctgc tcttatctac 480 actgtctttg ccatgtgtct gccatactgt ggtcccaaca agatcaacca cttcttttgt 540 gaagtccctg cagtcttaaa gctagcttgt gcggacacat cagtcaatga ctgggtagac 600 ttcattctcg gctttagtgt catcctggtc ccactctccc tcatccttgt catttatgtc 660 aacatcttcg ttgccatctt gaggatccgt tcagcccagg ggcgactgaa ggccttctcc 720 acttgtgcct ctcatatcat tgtggtcacc acgttctgtg taccagccat ggtcatgtat 780 atgaagcctg gctctgaggc ctccctggaa gaggacaaga gattggcact gttctacaat 840 gttgtctctg ctttcctcaa ccccatcatc tacagcctcc ggaataagga tgtgaagagg 900 gctttcctca aggtggcagg ttggagcagg gccccagaat aa 942

<210> 274 <211> 313 <212> PRT <213> Canis familiaris <400> 274

Met Met Glu Glu Phe Asn Gln Ser Ser Val Thr Glu Phe Ile Leu Leu 1 5 10 15 Gly Phe Ser Phe Asn Pro Arg Thr Thr Pro Leu Leu Phe Thr Val Phe 20 25 30 Leu Met Thr Tyr Leu Leu Ile Ile Leu Gly Asn Ser Leu Ile Thr Ile 35 40 45 Leu Ile Cys Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Ile 50 55 60

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Gly 65 Ile Leu Ser Ile Leu Asp Leu Gly Tyr Thr Thr Thr Thr Val Pro 70 75 80 Gln Met Leu Ala His Leu Ala Ser Gln Lys Lys Thr Ile Ser Phe Ala 85 90 95 Ser Cys Val Ala Gln Met Tyr Ile Phe Leu Val Leu Gly Ile Thr Glu 100 105 110 Ser Trp Leu Phe Ala Met Met Ser Ile Asp Arg Tyr Val Ala Ile Cys 115 120 125 His Pro Leu Arg Tyr Lys Val Ile Met Ser Pro Trp Leu Cys Gly Val 130 135 140 Met Val Ile Phe Cys Gly Leu Met Gly Ile Ile Ser Ala Leu Ile Tyr 145 150 155 160 Thr Val Phe Ala Met Cys Leu Pro Tyr Cys Gly Pro Asn Lys Ile Asn 165 170 175 His Phe Phe Cys Glu Val Pro Ala Val Leu Lys Leu Ala Cys Ala Asp 180 185 190 Thr Ser Val Asn Asp Trp Val Asp Phe Ile Leu Gly Phe Ser Val Ile 195 200 205 Leu Val Pro Leu Ser Leu Ile Leu Val Ile Tyr Val Asn Ile Phe Val 210 215 220 Ala Ile Leu Arg Ile Arg Ser Ala Gln Gly Arg Leu Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Ile Ile Val Val Thr Thr Phe Cys Val Pro Ala 245 250 255 Met Val Met Tyr Met Lys Pro Gly Ser Glu Ala Ser Leu Glu Glu Asp 260 265 270

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Lys Arg Leu Ala Leu Phe Tyr Asn Val Val Ser Ala Phe Leu Asn Pro 275 280 285 Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Arg Ala Phe Leu Lys

300

290 295

Val Ala Gly Trp Ser Arg Ala Pro Glu 305 310 <210> 275 <211> 948 <212> DNA <213> Canis familiaris <400> 275 atgcagaact tcccctggga caaccacagc tccagggatt cccaaattaa cgcaatcctc acacttgtgg gcaatgggct cattatcacc cccatgtact tcttcctcag tgtcctctcc gtgccccaga tgttggtgca tctgatctgc gtggctcaga tgtacatctt tctggtgttg atggcctatg acagatatgt agccatctgt ccatggctgt gtggggcaat ggtggtcttt gtctacactg tcttcacaat gcgcctgccc ttctgcgagg tccctgctgt tctgaagctg gtagatttca tcctgggttt catccttctc tatgtctgca tctttgccac tatcttgaag ttctccacct gtgcctccca catcactgtg atgtacatga accctggggc caatgcctcc tacaatgtta tctctgcctt tctcaacccc aagagggctt ttctcaagtt aacaggctgg tctgtgtctg ttcaatatct ttgatctact atgctggaca cagaagaaaa ggcatcactg tacccactca tgtggattgt tattgtggcc gcatgtgcag ctggtacctc atccgctcgg gtcaccatgt ccagagcggg atcatctata ggcagggcct

aattcattct tctgggcttc 60 tcctctttct ctacctctct 120 tggactcccg cctccacaca 180 tgagctatgt caccaccact 240 ctatctctta tgttgggtgt 300 agggctggct cttctccgtc 360 ggtacaaggt tatcatgacc 420 ggggaatcag ctgttccctg 480 ctaatgagat caatcacttc 540 acacatccct caacgaccaa 600 tttccttcat tctggcctct 660 cccaaggccg actcaagacc 720 tctgtgggcc tgccatgttt 780 acaagaaact ggctctgttc 840 gccttagaaa caaagatgtt 900 ctgagtaa 948

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069269_0225_SL.TXT <210> 276 <211> 315 <212> PRT <213> Canis familiaris <400> 276

Met 1 Gln Asn Phe Pro Trp Asp Asn His Ser Ser Val Ser Glu Phe Ile 5 10 15 Leu Leu Gly Phe Ser Arg Asp Ser Gln Ile Asn Ala Ile Leu Phe Asn 20 25 30 Ile Phe Leu Phe Leu Tyr Leu Ser Thr Leu Val Gly Asn Gly Leu Ile 35 40 45 Ile Thr Leu Ile Tyr Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Ser Val Leu Ser Met Leu Asp Met Ser Tyr Val Thr Thr Thr 65 70 75 80 Val Pro Gln Met Leu Val His Leu Ile Cys Gln Lys Lys Thr Ile Ser 85 90 95 Tyr Val Gly Cys Val Ala Gln Met Tyr Ile Phe Leu Val Leu Gly Ile 100 105 110 Thr Glu Gly Trp Leu Phe Ser Val Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys Tyr Pro Leu Arg Tyr Lys Val Ile Met Thr Pro Trp Leu Cys 130 135 140 Gly Ala Met Val Val Phe Cys Gly Leu Trp Gly Ile Ser Cys Ser Leu 145 150 155 160 Val Tyr Thr Val Phe Thr Met Arg Leu Pro Tyr Cys Gly Pro Asn Glu 165 170 175 Ile Asn His Phe Phe Cys Glu Val Pro Ala Val Leu Lys Leu Ala Cys

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180

069269_0225_SL.TXT 185 190

Ala Asp Thr Ser Leu Asn Asp Gln Val Asp Phe Ile Leu Gly Phe Ile 195 200 205 Leu Leu Leu Val Pro Leu Ser Phe Ile Leu Ala Ser Tyr Val Cys Ile 210 215 220 Phe Ala Thr Ile Leu Lys Ile Arg Ser Ala Gln Gly Arg Leu Lys Thr 225 230 235 240 Phe Ser Thr Cys Ala Ser His Ile Thr Val Val Thr Met Phe Cys Gly 245 250 255 Pro Ala Met Phe Met Tyr Met Asn Pro Gly Ala Asn Ala Ser Pro Glu 260 265 270 Arg Asp Lys Lys Leu Ala Leu Phe Tyr Asn Val Ile Ser Ala Phe Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Arg Ala Phe 290 295 300 Leu Lys Leu Thr Gly Trp Gly Arg Ala Ser Glu

305 310 315 <210> 277 <211> 924 <212> DNA <213> Canis familiaris <400> 277

atggaaaata acaacagtac ggtggtgaaa gaattcatcc ttcttagtct aacccagtct 60 cgaaatattc agctcttggt ctttgtgcta gttttaatct tctatttcat catcctccct 120 ggaaacttcc tcatcatcct caccatcaga acagatcctg gcctcacagc ccccctctac 180 ttctttctgg gcaacttggc tttcctggat gcatcctact ccttcattgt ggctcccagg 240 atgctggtgg acttcctttc tgagaagaag gtaatctcct acaggggttg catcactcag 300 ctctttttct tgcacttcct tggaggaggg gaaggattac tccttgttgt gatggccttt 360

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gaccgctaca ttgccatctg tcggccttta cactattcaa ctgtcatgaa ccctagagcc 420 tgctatgcct tgctattggc tctgtggctt ggaggctttg tccactccat tatccaggtg 480 gccctcatcc tccgcttgcc cttctgtggc ccaaaccgac tggataactt cttctgtgat 540 gtgccgcagg tcatcaagct ggcctgcacg gacacctttg tggtggagct tctgatggtc 600 ttcaatagtg gtctgatgac cctcttgtgc ttcctgggcc ttctggcctc atatgcagtg 660 atcctctgcc gtgtacatgg gtcctcctct gaggggaaga acaaggcagt atccacatgc 720 accacccata tcattgttat atttcttatg tttgggcccg gcatcttcat ctacactcgc 780 cccttcagag ccttcccagc tgacaaagtg gtttctcttt ttcacacagt gatctttcct 840 ttgttgaatc ctgtgattta tacccttcgt aaccaggaag taaaagcttc tatgaagagg 900 ctatttaatc agaatagagc ctaa 924

<210> 278 <211> 307 <212> PRT <213> Canis familiaris <400> 278

Met Glu Asn Asn Asn Ser Thr Val Val Lys Glu Phe Ile Leu Leu Ser 1 5 10 15 Leu Thr Gln Ser Arg Asn Ile Gln Leu Leu Val Phe Val Leu Val Leu 20 25 30 Ile Phe Tyr Phe Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Leu Thr 35 40 45 Ile Arg Thr Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg 65 70 75 80 Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly 85 90 95

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Cys Ile Thr Gln 100 Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly 105 110 Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Ser Thr Val Met Asn Pro Arg Ala Cys Tyr Ala Leu 130 135 140 Leu Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val 145 150 155 160 Ala Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Arg Leu Asp Asn 165 170 175 Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu 195 200 205 Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg 210 215 220 Val His Gly Ser Ser Ser Glu Gly Lys Asn Lys Ala Val Ser Thr Cys 225 230 235 240 Thr Thr His Ile Ile Val Ile Phe Leu Met Phe Gly Pro Gly Ile Phe 245 250 255 Ile Tyr Thr Arg Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser 260 265 270 Leu Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Val Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Ala Ser Met Lys Arg Leu Phe Asn Gln 290 295 300

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Asn Arg Ala

305 <210> 279 <211> 969 <212> DNA <213> Canis familiaris <400> 279 atgaaaaacc cagtcgaaaa taaccactct gactctgtga gtgaattcat tcttcttgga 60 ttcccttgtc cctgggagat tcagatcctc ctcttctcat tcttctttgt gatctatgtc 120 ctgacactaa ctggaaatct gtgtattatc tctgcagtgt ggtgggatga gtatctccac 180 acccccatgt atatcctgct ggccaatttt tccttcctgg agatctggta tgtcacttct 240 actgtcccaa atatgctagc caacttgcta tctgagacca gtaccatctc cttctatggc 300 tgcttcctcc aattctactt cttcttctcc atgggcacca ctgagacctt cttcttgtct 360 gccatggcct ttgacaggta tcttgctatc tgcaggcccc tgcattactc cactgtcatg 420 actgttcagc gttgcatcag aataggagcc gggtgctggg tgtgtggctt ctcctgtttt 480 ctcctcccag tttaccttat ctctcaactt cctttttgtg gtcctaatac aattgatcat 540 tttttatgtg atccagggcc ccttatgaag ctgtcctgtg tgccagctac tgctactgag 600 gtcatctgtg ccgtctttaa ctcagtcctc attttctcca ccttcctttt cattaccagc 660 tcctatactc tggttatcag agctgtgctg agggtcccct cagcagaagg ccggcataag 720 gccttctcca catgtggctc ccatcttgct gttgtgtctc tgttctatgg ctctatcatg 780 gtgatgtatg tgagcccaac agcaggcaat ccagcaggga ttcagaaaat tgtgacttta 840 ttttattctg tgatgactcc actttttaat cccttgatct acagcctccg gaataaggag 900 atgaagatgg ccctgagaaa attgtttagg attatgagat ttggtcaaaa acagcctttc 960 aagaactag 969 <210> 280 <211> 322 <212> PRT <213> Canis familiaris <400> 280

Met Lys Asn Pro Val Glu Asn Asn His Ser Asp Ser Val Ser Glu Phe Page 310

0 6926 9_02 25_S L.TX T 1 5 10 15 Ile Leu Leu Gly Phe Pro Cys Pro Trp Glu Ile Gln Ile Leu Leu Phe 20 25 30 Ser Phe Phe Phe Val Ile Tyr Val Leu Thr Leu Thr Gly Asn Leu Cys 35 40 45 Ile Ile Ser Ala Val Trp Trp Asp Glu Tyr Leu His Thr Pro Met Tyr 50 55 60 Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val Thr Ser 65 70 75 80 Thr Val Pro Asn Met Leu Ala Asn Leu Leu Ser Glu Thr Ser Thr Ile 85 90 95 Ser Phe Tyr Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Met Gly 100 105 110 Thr Thr Glu Thr Phe Phe Leu Ser Ala Met Ala Phe Asp Arg Tyr Leu 115 120 125 Ala Ile Cys Arg Pro Leu His Tyr Ser Thr Val Met Thr Val Gln Arg 130 135 140 Cys Ile Arg Ile Gly Ala Gly Cys Trp Val Cys Gly Phe Ser Cys Phe 145 150 155 160 Leu Leu Pro Val Tyr Leu Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn 165 170 175 Thr Ile Asp His Phe Leu Cys Asp Pro Gly Pro Leu Met Lys Leu Ser 180 185 190 Cys Val Pro Ala Thr Ala Thr Glu Val Ile Cys Ala Val Phe Asn Ser 195 200 205 Val Leu Ile Phe Ser Thr Phe Leu Phe Ile Thr Ser Ser Tyr Thr Leu

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210 215 Pro Ser Ala 235 220 His Lys 240 Val 225 Ile Arg Ala Val Leu 230 Arg Val Glu Gly Arg Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr 245 250 255 Gly Ser Ile Met Val Met Tyr Val Ser Pro Thr Ala Gly Asn Pro Ala 260 265 270 Gly Ile Gln Lys Ile Val Thr Leu Phe Tyr Ser Val Met Thr Pro Leu 275 280 285 Phe Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Met Lys Met Ala 290 295 300 Leu Arg Lys Leu Phe Arg Ile Met Arg Phe Gly Gln Lys Gln Pro Phe 305 310 315 320

Lys Asn <210> 281 <211> 969 <212> DNA <213> Canis familiaris <400> 281

atgtcttcca gaccaatgaa tgcgtccagc acagaaacca ccaactccgt tagccacttc 60 atcctcctgg gctttccctc aagcccagaa atgcaactgc tctactttgg gctcttctca 120 gtagtctaca ccctgactct gatggggaac gcagccattg tctgtgctgt gcagtgggat 180 cggcgtcttc acactcccat gtacatcttc ttggggaatt tctctcttct ggaaatatgt 240 tatgtcacca cgactgttcc taacatgttg gccaatttcc tctctacaag taagtccatt 300 tcctttgtga gctgcttcac acagttctat ttcttcttct cttttggata tgatgaaggc 360 ttcttccttt gcatcatggc ctttgacagg taccttgcca tttgtaatcc tctccattac 420 ccacgcatca tgactaagca gctatatact ggccttgtca tcttcgggtg gtcgagtggg 480

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ttcttcctct tcctaacccc agttgttctc atttcacagt tgccctactg tggcccaaat 540 accatcaacc attttttatg tgaccccgtc ccactgatga tgctgtcctg ttctgaagat 600 gccatcactc agctcattta ctctactttc aatgctattt tcatgattgg cacctttctc 660 tttatccttt gctcctatgc tctggtgatt ctgactgtgc tgtggatgcc ctcacaggct 720 ggcaaacgca aggctttctc cacttgtgct tctcatttgg cagttgtcac cctgttttat 780 ggctctatta tggtgatgta tgttagtcct ggatcaggac acccagtgaa aattcaaaaa 840 ttcattacct tattttattc agtgataaca cccctctgca atcctctaat ctatagcctt 900 aggaacaagg aaatgaagaa tgctctgagg aaaatctttg ggactgaaca tggtgttcat 960

aaagtgtaa 969 <210> 282 <211> 322 <212> PRT <213> Canis familiaris <400> 282

Met Ser Ser Arg Pro Met Asn Ala Ser Ser Thr Glu Thr Thr Asn Ser 1 5 10 15 Val Ser His Phe Ile Leu Leu Gly Phe Pro Ser Ser Pro Glu Met Gln 20 25 30 Leu Leu Tyr Phe Gly Leu Phe Ser Val Val Tyr Thr Leu Thr Leu Met 35 40 45 Gly Asn Ala Ala Ile Val Cys Ala Val Gln Trp Asp Arg Arg Leu His 50 55 60 Thr Pro Met Tyr Ile Phe Leu Gly Asn Phe Ser Leu Leu Glu Ile Cys 65 70 75 80 Tyr Val Thr Thr Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Thr 85 90 95 Ser Lys Ser Ile Ser Phe Val Ser Cys Phe Thr Gln Phe Tyr Phe Phe 100 105 110

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Phe Ser Phe 115 Gly Tyr Asp Glu Gly Phe Phe Leu Cys Ile Met Ala Phe 120 125 Asp Arg Tyr Leu Ala Ile Cys Asn Pro Leu His Tyr Pro Arg Ile Met 130 135 140 Thr Lys Gln Leu Tyr Thr Gly Leu Val Ile Phe Gly Trp Ser Ser Gly 145 150 155 160 Phe Phe Leu Phe Leu Thr Pro Val Val Leu Ile Ser Gln Leu Pro Tyr 165 170 175 Cys Gly Pro Asn Thr Ile Asn His Phe Leu Cys Asp Pro Val Pro Leu 180 185 190 Met Met Leu Ser Cys Ser Glu Asp Ala Ile Thr Gln Leu Ile Tyr Ser 195 200 205 Thr Phe Asn Ala Ile Phe Met Ile Gly Thr Phe Leu Phe Ile Leu Cys 210 215 220 Ser Tyr Ala Leu Val Ile Leu Thr Val Leu Trp Met Pro Ser Gln Ala 225 230 235 240 Gly Lys Arg Lys Ala Phe Ser Thr Cys Ala Ser His Leu Ala Val Val 245 250 255 Thr Leu Phe Tyr Gly Ser Ile Met Val Met Tyr Val Ser Pro Gly Ser 260 265 270 Gly His Pro Val Lys Ile Gln Lys Phe Ile Thr Leu Phe Tyr Ser Val 275 280 285 Ile Thr Pro Leu Cys Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu 290 295 300 Met Lys Asn Ala Leu Arg Lys Ile Phe Gly Thr Glu His Gly Val His 305 310 315 320

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Lys Val <210> 283 <211> 738 <212> DNA <213> Canis familiaris <400> 283 atgccttcca gaccaatgac tgcgtccagc acagaaacca ccaactccat tagccacttc 60 atcctcctgg gctttccctc aagcccagaa atgcagctgc tctactttgg gctcttctca 120 gtagtctaca ccctgaccct gatggggaac acagccattg tctgtgctgt gcactgggac 180 cggcatcttc acactcccat gtacatcttc ttggggaatt tctctcttct ggaaatatgt 240 tatgtcacca ggaccgttcc ctatatgtca gccaatttcc tgtccacaag caagtctatc 300 tcctttgtgt gctgtttcac acagttctat ttcttcttct cttcggggtg tgatgaaggc 360 ttcttccttt gcatcatggc ctttgacagg taccttgcca tttgtcatcc tctccattac 420 ccacgcatca tgactaagca gctatacact ggccttgtca tcttcgggtg gtcgagtggg 480 ttcttcctct tcctaacccc agttgttctc atttcacagt tgccctactg tggcccaaat 540 accatcaacc attttttatg tgaccccgtc ccactgatga ttctgtactg ttctgaagat 600 tccatcactc agctcattta ctctactttc aatgctattt tcatgattag cacctttctc 660 tttctctttt gcttctatgc tctggtgatt gtggctgtgc tacggatgcc ctcaggagca 720 agcaaacagc aaggcttt 738 <210> 284 <211> 246 <212> PRT <213> Canis familiaris <400> 284

Met 1 Pro Ser Arg Pro Met 5 Thr Ala Ser Ser Thr Glu Thr Thr Asn Ser 10 15 Ile Ser His Phe Ile Leu Leu Gly Phe Pro Ser Ser Pro Glu Met Gln 20 25 30

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Leu Leu Tyr 35 Phe Gly Leu Phe Ser Val Val Tyr Thr Leu Thr Leu Met 40 45 Gly Asn Thr Ala Ile Val Cys Ala Val His Trp Asp Arg His Leu His 50 55 60 Thr Pro Met Tyr Ile Phe Leu Gly Asn Phe Ser Leu Leu Glu Ile Cys 65 70 75 80 Tyr Val Thr Arg Thr Val Pro Tyr Met Ser Ala Asn Phe Leu Ser Thr 85 90 95 Ser Lys Ser Ile Ser Phe Val Cys Cys Phe Thr Gln Phe Tyr Phe Phe 100 105 110 Phe Ser Ser Gly Cys Asp Glu Gly Phe Phe Leu Cys Ile Met Ala Phe 115 120 125 Asp Arg Tyr Leu Ala Ile Cys His Pro Leu His Tyr Pro Arg Ile Met 130 135 140 Thr Lys Gln Leu Tyr Thr Gly Leu Val Ile Phe Gly Trp Ser Ser Gly 145 150 155 160 Phe Phe Leu Phe Leu Thr Pro Val Val Leu Ile Ser Gln Leu Pro Tyr 165 170 175 Cys Gly Pro Asn Thr Ile Asn His Phe Leu Cys Asp Pro Val Pro Leu 180 185 190 Met Ile Leu Tyr Cys Ser Glu Asp Ser Ile Thr Gln Leu Ile Tyr Ser 195 200 205 Thr Phe Asn Ala Ile Phe Met Ile Ser Thr Phe Leu Phe Leu Phe Cys 210 215 220 Phe Tyr Ala Leu Val Ile Val Ala Val Leu Arg Met Pro Ser Gly Ala 225 230 235 240

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Ser Lys Gln Gln Gly Phe 245 <210> 285 <211> 969 <212> DNA <213> Canis familiaris <400> 285

atgagtatct caggagccaa caatatctct gggtctgtga gtgagttcat tctcctgggc 60 ttcccctgcc gcagggagct ccaggtcctg ctctttgtca tcttctcaat catctacctt 120 ctgactctca tggggaacac atccatcatc tgcgccgtgg cgtcaagccg gaaactccac 180 acgcccatgt acatcctgct ggccaacttc tctttgctgg agatctgcta tgtcagttct 240 gatgtgccca agatgttggc caacatcatc tcccagacca agagcatctc ctacgccggc 300 tgcctgctcc agttctattt cttcttctcc atgtgtgccg ctgagggcta ctttctgtct 360 gcgatgtcct atgatcggtt ccttgctatc tgtcgacctc tacattaccc caccatcatg 420 actcaccatc tatgtgcccg attagtggtt ttctgctggg taggtggctt tctatccata 480 ctgatacctg caattcttat gtcccaggtg cccttctgtg gccctaatat cattgaccat 540 tttttctgtg acctgggacc actgctggct ctgtcctgtg ctccagttcc caaaactact 600 ctaacttgtg ctaccgtaag ctcccttatc atcttcatca cttttctcta catccttgga 660 tcctatacct tagttttgcg agccgtactt cgagtcccag ctggctcagg taggaacaaa 720 gctttttcta catgtgcttc acatttcttg gtggtttcct tgttctatgg ctcagtcatg 780 gtgatgtatg tgagtccagg atccaggagc catcctggga cacagaaatt tgtgaccttg 840 ttttactgca tggcaacccc tttctttaat cctctgatct acagccttcg aaacaaagat 900 atgaaagatg cactcaagaa agtcctggga gcatcatcaa aagaaatttc taaaaataca 960

gagaaatga 969 <210> 286 <211> 322 <212> PRT <213> Canis familiaris <400> 286

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Met 1 Ser Ile Ser Gly 5 Ala Asn Asn Ile Ser Gly Ser Val Ser Glu Phe 10 15 Ile Leu Leu Gly Phe Pro Cys Arg Arg Glu Leu Gln Val Leu Leu Phe 20 25 30 Val Ile Phe Ser Ile Ile Tyr Leu Leu Thr Leu Met Gly Asn Thr Ser 35 40 45 Ile Ile Cys Ala Val Ala Ser Ser Arg Lys Leu His Thr Pro Met Tyr 50 55 60 Ile Leu Leu Ala Asn Phe Ser Leu Leu Glu Ile Cys Tyr Val Ser Ser 65 70 75 80 Asp Val Pro Lys Met Leu Ala Asn Ile Ile Ser Gln Thr Lys Ser Ile 85 90 95 Ser Tyr Ala Gly Cys Leu Leu Gln Phe Tyr Phe Phe Phe Ser Met Cys 100 105 110 Ala Ala Glu Gly Tyr Phe Leu Ser Ala Met Ser Tyr Asp Arg Phe Leu 115 120 125 Ala Ile Cys Arg Pro Leu His Tyr Pro Thr Ile Met Thr His His Leu 130 135 140 Cys Ala Arg Leu Val Val Phe Cys Trp Val Gly Gly Phe Leu Ser Ile 145 150 155 160 Leu Ile Pro Ala Ile Leu Met Ser Gln Val Pro Phe Cys Gly Pro Asn 165 170 175 Ile Ile Asp His Phe Phe Cys Asp Leu Gly Pro Leu Leu Ala Leu Ser 180 185 190 Cys Ala Pro Val Pro Lys Thr Thr Leu Thr Cys Ala Thr Val Ser Ser 195 200 205

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Leu Ile Ile Phe Ile Thr Phe Leu 215 Tyr Ile Leu Gly Ser Tyr Thr Leu 220 210 Val Leu Arg Ala Val Leu Arg Val Pro Ala Gly Ser Gly Arg Asn Lys 225 230 235 240 Ala Phe Ser Thr Cys Ala Ser His Phe Leu Val Val Ser Leu Phe Tyr 245 250 255 Gly Ser Val Met Val Met Tyr Val Ser Pro Gly Ser Arg Ser His Pro 260 265 270 Gly Thr Gln Lys Phe Val Thr Leu Phe Tyr Cys Met Ala Thr Pro Phe 275 280 285 Phe Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala 290 295 300 Leu Lys Lys Val Leu Gly Ala Ser Ser Lys Glu Ile Ser Lys Asn Thr 305 310 315 320

Glu Lys <210> 287 <211> 942 <212> DNA <213> Canis familiaris <400> 287

atgacctcag aggccagaaa cgcttcccgt agtgggcagg acttcatcct cctgggcttc 60 ccttgcagcc gggaagtcca attcctcctc ttctctatat tctttgtgac ctacacgctg 120 acgctccttg gaaacacggt catcgtgtgt gcggtgcacg gggaccgccg gcttcacacc 180 ccgatgtatg tcctgctggc caacttctcc ttcctggaga tctgctacgt caactccgat 240 gtgcccaaca tgctggccaa cctcctctcc cagaccaaaa ccatctcctt cgctcggtgc 300 ctgctccagt tgtacttctt cttctccctg ggcacaaccg aatgcttgtt tctgtccatc 360 atggcctatg accgcttcct tgccatctgc cgccccctgc actatcccac tgtcatgact 420

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attaagttct gtgtccgtct ggtcatcttt tgctgggtct atggttttct ctggtttctg 480 atccctgtga tactcgtgac ccagctaccg ttttgcggcc cgaatgtaat tgatgacttt 540 ctgtgtgacc tgggtcctct gctggccttg gcttcagcct gtgtcccaat cccagggact 600 gttctcatct gtggcaccat gagttccctc ctcatctttg ccaccttcct gtacataatc 660 ggctcctaca gcctggtggt gtgggttgta gtgcaggtgc cctccagagc cggccggaag 720 aaagcctttt ctacctgctg ctcacatctg gctgtcgtgt ttctattcta tggttccgtc 780 atgatgacat atgtgagccc agggtcagga caagcagagg gaatgcagaa gttcacgact 840 ctattctact cagttttgac cccttttttc aaccccatga tctacagcct ccggaataaa 900 gaaatgaagg ctgccttgaa gaaaattctg ggaggttcct aa 942

<210> 288 <211> 313 <212> PRT <213> Canis familiaris <400> 288

Met Thr Ser Glu Ala Arg Asn Ala Ser Arg Ser Gly Gln Asp Phe Ile 1 5 10 15 Leu Leu Gly Phe Pro Cys Ser Arg Glu Val Gln Phe Leu Leu Phe Ser 20 25 30 Ile Phe Phe Val Thr Tyr Thr Leu Thr Leu Leu Gly Asn Thr Val Ile 35 40 45 Val Cys Ala Val His Gly Asp Arg Arg Leu His Thr Pro Met Tyr Val 50 55 60 Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val Asn Ser Asp 65 70 75 80 Val Pro Asn Met Leu Ala Asn Leu Leu Ser Gln Thr Lys Thr Ile Ser 85 90 95 Phe Ala Arg Cys Leu Leu Gln Leu Tyr Phe Phe Phe Ser Leu Gly Thr 100 105 110

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Thr Glu Cys 115 Leu Phe Leu Ser Ile Met Ala Tyr Asp Arg Phe Leu Ala 120 125 Ile Cys Arg Pro Leu His Tyr Pro Thr Val Met Thr Ile Lys Phe Cys 130 135 140 Val Arg Leu Val Ile Phe Cys Trp Val Tyr Gly Phe Leu Trp Phe Leu 145 150 155 160 Ile Pro Val Ile Leu Val Thr Gln Leu Pro Phe Cys Gly Pro Asn Val 165 170 175 Ile Asp Asp Phe Leu Cys Asp Leu Gly Pro Leu Leu Ala Leu Ala Ser 180 185 190 Ala Cys Val Pro Ile Pro Gly Thr Val Leu Ile Cys Gly Thr Met Ser 195 200 205 Ser Leu Leu Ile Phe Ala Thr Phe Leu Tyr Ile Ile Gly Ser Tyr Ser 210 215 220 Leu Val Val Trp Val Val Val Gln Val Pro Ser Arg Ala Gly Arg Lys 225 230 235 240 Lys Ala Phe Ser Thr Cys Cys Ser His Leu Ala Val Val Phe Leu Phe 245 250 255 Tyr Gly Ser Val Met Met Thr Tyr Val Ser Pro Gly Ser Gly Gln Ala 260 265 270 Glu Gly Met Gln Lys Phe Thr Thr Leu Phe Tyr Ser Val Leu Thr Pro 275 280 285 Phe Phe Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys Glu Met Lys Ala 290 295 300 Ala Leu Lys Lys Ile Leu Gly Gly Ser

305 310

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069269_0225_SL.TXT <210> 289 <211> 939 <212> DNA <213> Canis familiaris <400> 289

atgtcaggag tcagcacagt gactgaattc atactcctga gttttctctg ctccagaaag 60 gttcaggtcc tcctcttcct gctgttcttt gtgtcctaca tcctgacact gatggggaat 120 ggggccattg tctgtgcagt gaagctggat cccagacttc atacccccat gtaccttctg 180 ctggccaact tctcgttcct ggagatctgt tacatcaaca ccaccgttcc caatatgtta 240 cagaacttcc tatctgagac caaaaccatc tctttcacag cctgtttctt tcagttctac 300 ttcttcttct ccatgggcac cactgagact ttcttactgc ccctcatggc ttttgatcgg 360 tacttggcca tctgccagcc tctccattat cctatcatca tgaacaaccg cctctgcatg 420 aacctggtgg ccctgtgctg ggtcacagcc ttcctctgct atccgatccc tatctatttt 480 atcacacagc tccccttctg tggccccaac gccattgacc actttgtctg tgaccccggt 540 cctcttctgg ccctgtcctg catccctgcc cctggaattg agctttcctg ttctctattg 600 agctctctca ttatcttcat caccttcttc ttcatccttg gttcgtacac actggttctc 660 agagcagtgt tgcgtgtccc ctcagcagct ggtcgacgta aggccttctc cacctgtggt 720 tcccacttgg ttgtggtctc tcttttctat ggagccctca tggtaatgta catcagccca 780 acctctggaa atccatctgg gatacagaag attgtaacct tgttctactc atcagtgacc 840 ccacttataa acccactgat ctacagtcta cggaacaaag acatgaaagc tgccttgaga 900 aaaattcata tgagcacaaa aattagtcaa agcaaataa 939

<210> 290 <211> 312 <212> PRT <213> Canis familiaris <400> 290

Met Ser Gly Val Ser Thr Val Thr Glu Phe Ile Leu Leu Ser Phe Leu 1 5 10 15

Cys Ser Arg Lys Val Gln Val Leu Leu Phe Leu Leu Phe Phe Val Ser 20 25 30

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Tyr Ile Leu 35 Thr Leu Met Gly Asn Gly Ala Ile Val Cys Ala Val Lys 40 45 Leu Asp Pro Arg Leu His Thr Pro Met Tyr Leu Leu Leu Ala Asn Phe 50 55 60 Ser Phe Leu Glu Ile Cys Tyr Ile Asn Thr Thr Val Pro Asn Met Leu 65 70 75 80 Gln Asn Phe Leu Ser Glu Thr Lys Thr Ile Ser Phe Thr Ala Cys Phe 85 90 95 Phe Gln Phe Tyr Phe Phe Phe Ser Met Gly Thr Thr Glu Thr Phe Leu 100 105 110 Leu Pro Leu Met Ala Phe Asp Arg Tyr Leu Ala Ile Cys Gln Pro Leu 115 120 125 His Tyr Pro Ile Ile Met Asn Asn Arg Leu Cys Met Asn Leu Val Ala 130 135 140 Leu Cys Trp Val Thr Ala Phe Leu Cys Tyr Pro Ile Pro Ile Tyr Phe 145 150 155 160 Ile Thr Gln Leu Pro Phe Cys Gly Pro Asn Ala Ile Asp His Phe Val 165 170 175 Cys Asp Pro Gly Pro Leu Leu Ala Leu Ser Cys Ile Pro Ala Pro Gly 180 185 190 Ile Glu Leu Ser Cys Ser Leu Leu Ser Ser Leu Ile Ile Phe Ile Thr 195 200 205 Phe Phe Phe Ile Leu Gly Ser Tyr Thr Leu Val Leu Arg Ala Val Leu 210 215 220 Arg Val Pro Ser Ala Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys Gly 225 230 235 240

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Ser His Leu Val Val 245 Val Ser Leu Tyr Ile Ser Pro 260 Thr Ser Gly Asn Thr Leu Phe 275 Tyr Ser Ser Val Thr 280 Ser Leu 290 Arg Asn Lys Asp Met 295 Lys Ser 305 Thr Lys Ile Ser Gln 310 Ser Lys

Phe Tyr 250 Gly Ala Leu Met Val 255 Met Pro 265 Ser Gly Ile Gln Lys 270 Ile Val Pro Leu Ile Asn Pro 285 Leu Ile Tyr Ala Ala Leu Arg Lys Ile His Met

300 <210> 291 <211> 936 <212> DNA <213> Canis familiaris <400> 291 atgaaagtct ccagcaccac caacacatcc ttcccttgct ccagggaggg gcagctcctc ctcaccctca tgggcaatgg gtctatcatc actcccatgt acatcctgct cgccaacttc actgtcccca acatgctggc caacttcctc tgctttctcc agttctactt tttcttctcc attatggcgt ttgatcggta ccttgccatc acaggacgtc tctgtgccag tcttgtggtc ttgattccca tcatcatcat ctcccaaatg ttcctatgtg atccaggtcc cctgttggcc ttaactagct ccaccttaag ttctctgctc tcctacactc tggtcctgaa agctgtgttg agcaccatct ccggcttcat cctcctgggc ctctttgggc tcttctccgt tctctacctc tgtgccgtgc gctgggacca gagactccac tccttcctag agatctggta cgtcacctcg tctgacacca aggtcatctc cttctccggg ttgggttcta cagaatgttt tttcttggct tgccggcctc tacactaccc aaccattatg agttgctggg tacttggttt cttctggttc tccttctgtg gatccaggat cattgaccac ctcacctgta ctagagcccc tgtgatagag ttgtttattc cctttctctt tatcatggtg aaagtccctt ctgcagctgg acgaagaaag

120

180

240

300

360

420

480

540

600

660

720

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069269_0225_SL.TXT gctttctcca cctgtgggtc tcatctggcc gtggtttcac tgttctatgg ctcagtgatg gtcatgtatg tgagcccaac atctgagcat gaagctggga tgcagaagat ggtgactttg ttttattcca tagttactcc acttatcaac cctgtaatat atagtctaag gaacaaagat atgaaacatg ctatgaagaa attactgaga acataa

780

840

900

936 <210> 292 <211> 311 <212> PRT <213> Canis familiaris <400> 292

Met 1 Lys Val Ser Ser 5 Thr Thr Asn Thr Ser Ser Thr Ile Ser Gly Phe 10 15 Ile Leu Leu Gly Phe Pro Cys Ser Arg Glu Gly Gln Leu Leu Leu Phe 20 25 30 Gly Leu Phe Ser Val Leu Tyr Leu Leu Thr Leu Met Gly Asn Gly Ser 35 40 45 Ile Ile Cys Ala Val Arg Trp Asp Gln Arg Leu His Thr Pro Met Tyr 50 55 60 Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val Thr Ser 65 70 75 80 Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Val Ile 85 90 95 Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly 100 105 110 Ser Thr Glu Cys Phe Phe Leu Ala Ile Met Ala Phe Asp Arg Tyr Leu 115 120 125 Ala Ile Cys Arg Pro Leu His Tyr Pro Thr Ile Met Thr Gly Arg Leu 130 135 140 Cys Ala Ser Leu Val Val Ser Cys Trp Val Leu Gly Phe Phe Trp Phe

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145 150 155 160 Leu Ile Pro Ile Ile Ile Ile Ser Gln Met Ser Phe Cys Gly Ser Arg 165 170 175 Ile Ile Asp His Phe Leu Cys Asp Pro Gly Pro Leu Leu Ala Leu Thr 180 185 190 Cys Thr Arg Ala Pro Val Ile Glu Leu Thr Ser Ser Thr Leu Ser Ser 195 200 205 Leu Leu Leu Phe Ile Pro Phe Leu Phe Ile Met Val Ser Tyr Thr Leu 210 215 220 Val Leu Lys Ala Val Leu Lys Val Pro Ser Ala Ala Gly Arg Arg Lys 225 230 235 240 Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr 245 250 255 Gly Ser Val Met Val Met Tyr Val Ser Pro Thr Ser Glu His Glu Ala 260 265 270 Gly Met Gln Lys Met Val Thr Leu Phe Tyr Ser Ile Val Thr Pro Leu 275 280 285 Ile Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys His Ala 290 295 300 Met Lys Lys Leu Leu Arg Thr 305 310

<210> 293 <211> 936 <212> DNA <213> Canis familiaris <400> 293 atgaaagtct ccagcaccac caacacgtcc agcaccatct ccggcttcat cctcctgggc ttcccttgct ccagggaggg gcagctcctc ctctttgggc tcttctccgt tctctacctc Page 326

120

069269_0225_SL.TXT ctcaccctca tgggcaacgg gtctatcatc tgtgccgtgc gctgggacca gagactccac actcccatgt acatcctgct ctccaacttc tccttcctag agatctggta cgtcacctcg actgtcccca acatgctggc caacttcctc tctgacacca aggtcatctc cttctccggg tgctttctcc agttctactt tttcttctcc ttgggttcta cagaatgttt tttcttggct attatggcgt ttgatcggta ccttgccatc tgccggcctc tacactaccc aaccattatg acaggacgtc tctgtgccag tcttgtggtc agttgctggg tacttggttt tctctggttc ccagtcccta tcattgttat ttcccaaatg tccttctgtg gatccaggat cattgaccac ttcctatgtg atccgagtcc cctattagca ctcacctgtg ccagagctcc agtaatggag tttttttgga tgattttaag ttccttgctc ttatttattc ctttcttctg catcatgggg tcctatactc tggtcttgag agctgtgttg agggcccctt ctgcagctgg acgaagaaaa gctttctcta cctgtgggtc ccatctggct gtggtttcac tgttctatgg ctcagtgatg gtcatgtatc tgagcccgac atctgagcat gaatctggga tgcagaagat ggtgactctg ttttattctg taggaacccc actcattaat cctgtgatct atagtctaag gaacaaagat atgaaatgtg ccctgcagaa atttctagga atataa <210> 294 <211> 311 <212> PRT <213> Canis familiaris

180

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300

360

420

480

540

600

660

720

780

840

900

936 <400> 294

Met 1 Lys Val Ser Ser 5 Thr Thr Asn Thr Ser Ser Thr Ile Ser 10 Gly 15 Phe Ile Leu Leu Gly Phe Pro Cys Ser Arg Glu Gly Gln Leu Leu Leu Phe 20 25 30 Gly Leu Phe Ser Val Leu Tyr Leu Leu Thr Leu Met Gly Asn Gly Ser 35 40 45 Ile Ile Cys Ala Val Arg Trp Asp Gln Arg Leu His Thr Pro Met Tyr 50 55 60

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Ile 65 Leu Leu Ser Asn Phe 70 Ser Phe Leu Glu Ile Trp Tyr Val Thr Ser 75 80 Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Val Ile 85 90 95 Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly 100 105 110 Ser Thr Glu Cys Phe Phe Leu Ala Ile Met Ala Phe Asp Arg Tyr Leu 115 120 125 Ala Ile Cys Arg Pro Leu His Tyr Pro Thr Ile Met Thr Gly Arg Leu 130 135 140 Cys Ala Ser Leu Val Val Ser Cys Trp Val Leu Gly Phe Leu Trp Phe 145 150 155 160 Pro Val Pro Ile Ile Val Ile Ser Gln Met Ser Phe Cys Gly Ser Arg 165 170 175 Ile Ile Asp His Phe Leu Cys Asp Pro Ser Pro Leu Leu Ala Leu Thr 180 185 190 Cys Ala Arg Ala Pro Val Met Glu Phe Phe Trp Met Ile Leu Ser Ser 195 200 205 Leu Leu Leu Phe Ile Pro Phe Phe Cys Ile Met Gly Ser Tyr Thr Leu 210 215 220 Val Leu Arg Ala Val Leu Arg Ala Pro Ser Ala Ala Gly Arg Arg Lys 225 230 235 240 Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr 245 250 255 Gly Ser Val Met Val Met Tyr Leu Ser Pro Thr Ser Glu His Glu Ser 260 265 270

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Gly Met Gln Lys Met Val Thr Leu Phe Tyr Ser Val Gly Thr Pro Leu 275 280 285 Ile Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Cys Ala 290 295 300 Leu Gln Lys Phe Leu Gly Ile 305 310

<210> 295 <211> 936 <212> DNA <213> Canis familiaris <400> 295

atgaaagtct ccagcaccac caacacgtcc agcaccatct ccagcttcat cctcctgggc 60 ttcccttgct ccagggaggg gcagctcctc ctctttgggc tgttctccgt tctctacctc 120 ctcaccctca tgggcaacgg gtctatcatc tgtgccgtgt gctgggacca gagactccac 180 actcccatgt acatcttgct cgccaacttt tccttcctag agatctggta cgtcacctcg 240 actgtcccca acatgctggc caacttcctc tctgacacca aggtcatctc cttctccggg 300 tgctttctcc agttctactt tttcttctcc ttgggttcta cagaatgttt tttcttggct 360 attatggcgt ttgatcggta ccttgccatc tgccggcctc tacactaccc aaccattatg 420 acaggacgtc tctgcgccag gcttgtggtc agttgctggg tacttggttt cttctggttc 480 ttgattccca tcatcatcat ctcccaaatg tccttctgtg gatccaggat cattgaccac 540 ttcctatgtg atccaggtcc tcttctagca ctcacttgca aaaaagctcc tgtggtagag 600 cttgtcttct ccactctaag tcctctgccc ctcattattc cctttctctt catcatggga 660 tcctacactc tggtcctaag agcagtcctg aaagtccctt ccacagctgg acgaagaaag 720 gctttctcca cctgtgggtc tcatctggcc gtggtttcac tgttctatgg ctcagtgatg 780 gtcatgtatg ggagcccaac atctgagcat gaagctggaa cacagaagat cgtcactctg 840 ttttattctg tagtgacccc actccttaat cctgtgatat acagtcttag gaacaaagat 900 atgaagcatg ccctgaagaa acttctagga atataa 936

<210> 296

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069269_0225_SL.TXT <211> 311 <212> PRT <213> Canis familiaris <400> 296

Met 1 Lys Val Ser Ser Thr Thr 5 Asn Thr Ser Ser Thr Ile Ser Ser Phe 10 15 Ile Leu Leu Gly Phe Pro Cys Ser Arg Glu Gly Gln Leu Leu Leu Phe 20 25 30 Gly Leu Phe Ser Val Leu Tyr Leu Leu Thr Leu Met Gly Asn Gly Ser 35 40 45 Ile Ile Cys Ala Val Cys Trp Asp Gln Arg Leu His Thr Pro Met Tyr 50 55 60 Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val Thr Ser 65 70 75 80 Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Val Ile 85 90 95 Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly 100 105 110 Ser Thr Glu Cys Phe Phe Leu Ala Ile Met Ala Phe Asp Arg Tyr Leu 115 120 125 Ala Ile Cys Arg Pro Leu His Tyr Pro Thr Ile Met Thr Gly Arg Leu 130 135 140 Cys Ala Arg Leu Val Val Ser Cys Trp Val Leu Gly Phe Phe Trp Phe 145 150 155 160 Leu Ile Pro Ile Ile Ile Ile Ser Gln Met Ser Phe Cys Gly Ser Arg 165 170 175 Ile Ile Asp His Phe Leu Cys Asp Pro Gly Pro Leu Leu Ala Leu Thr 180 185 190

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Cys Lys Lys 195 Ala Pro Val Val Glu Leu Val Phe Ser Thr Leu Ser Pro 200 205 Leu Pro Leu Ile Ile Pro Phe Leu Phe Ile Met Gly Ser Tyr Thr Leu 210 215 220 Val Leu Arg Ala Val Leu Lys Val Pro Ser Thr Ala Gly Arg Arg Lys 225 230 235 240 Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr 245 250 255 Gly Ser Val Met Val Met Tyr Gly Ser Pro Thr Ser Glu His Glu Ala 260 265 270 Gly Thr Gln Lys Ile Val Thr Leu Phe Tyr Ser Val Val Thr Pro Leu 275 280 285 Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys His Ala 290 295 300 Leu Lys Lys Leu Leu Gly Ile 305 310

<210> 297 <211> 906 <212> DNA <213> Canis familiaris <400> 297

atgaacaatt cagagacaag cactgtggct gaatttgtcc tcttaggctt cactggttgt 60 caggaattgc aaagtttcct tttctcgttg ttctttggga tctatatatt taccataatg 120 ggaaacggga ccattgtctg tgctgtgatg ctggatcaac ggctccatac tccgatgtat 180 attctcctag ggaacttcgc tttcctcaaa atcttgtacg ttatgtccac ggtacccagg 240 atgctagcca atttcctctc ggagacaaaa accatctcct ttgttggctg tttcctccag 300 ttatattttt ttacttccct tggtacaagt gaaacctatt tcctctgcat catggcgtac 360 gatcagtacc tggctatctg ccatccactg cactactcaa ccaccatgac tcaacaattc 420

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tgctatatct tgatgtctct ttcctgggca ttggggtttc ttagttactc tgtctccacc 480 gtacagctct ctcaattgcc tttctgtgga cccaacacca ttgatcactt tgtgtgtgac 540 atggacccac tgatggctct gtcctgtgcc ccaaatctag tcatggagat catcctctat 600 atcctaagct ccctcattat catcctcaca cttctgtaca ttcttggctc ttatactttt 660 ttactgatag ttgtgttaaa agtgccttca gctgctggcc ggcaaagggc cttctccacc 720 tgtggataac atctgacagt ggtatgctta ttctttgggg cccttttggc aatgtatgtg 780 agccccacag ctgataaccc agctgaagtt cagaagattt tgactttgtt ctattccgtg 840 gtgactccct tcttaaaccc tctgatttac agtttatgaa acaaggaaat gaaggttgca 900

ctaaaa 906 <210> 298 <211> 242 <212> PRT <213> Canis familiaris <400> 298

Met Asn Asn Ser Glu Thr Ser Thr Val Ala Glu Phe Val Leu Leu Gly 1 5 10 15 Phe Thr Gly Cys Gln Glu Leu Gln Ser Phe Leu Phe Ser Leu Phe Phe 20 25 30 Gly Ile Tyr Ile Phe Thr Ile Met Gly Asn Gly Thr Ile Val Cys Ala 35 40 45 Val Met Leu Asp Gln Arg Leu His Thr Pro Met Tyr Ile Leu Leu Gly 50 55 60 Asn Phe Ala Phe Leu Lys Ile Leu Tyr Val Met Ser Thr Val Pro Arg 65 70 75 80 Met Leu Ala Asn Phe Leu Ser Glu Thr Lys Thr Ile Ser Phe Val Gly 85 90 95 Cys Phe Leu Gln Leu Tyr Phe Phe Thr Ser Leu Gly Thr Ser Glu Thr 100 105 110

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Tyr Phe Leu 115 Cys Ile Met Ala Tyr Asp Gln Tyr Leu Ala Ile Cys His 120 125 Pro Leu His Tyr Ser Thr Thr Met Thr Gln Gln Phe Cys Tyr Ile Leu 130 135 140 Met Ser Leu Ser Trp Ala Leu Gly Phe Leu Ser Tyr Ser Val Ser Thr 145 150 155 160 Val Gln Leu Ser Gln Leu Pro Phe Cys Gly Pro Asn Thr Ile Asp His 165 170 175 Phe Val Cys Asp Met Asp Pro Leu Met Ala Leu Ser Cys Ala Pro Asn 180 185 190 Leu Val Met Glu Ile Ile Leu Tyr Ile Leu Ser Ser Leu Ile Ile Ile 195 200 205 Leu Thr Leu Leu Tyr Ile Leu Gly Ser Tyr Thr Phe Leu Leu Ile Val 210 215 220 Val Leu Lys Val Pro Ser Ala Ala Gly Arg Gln Arg Ala Phe Ser Thr 225 230 235 240

Cys Gly <210> 299 <211> 927 <212> DNA <213> Canis familiaris <400> 299 atggaggcag aaaatagcac agtggtgaaa gaattcatcc ttcttggtct aacccagtct cgaaatattc agctcttggt ctttgtgcta gttttaatct tctatttcat catcctccct ggaaacttcc tcatcatcct caccatcaga acagatcctg gcctcacagc ccccctctac ttctttctgg gcaacttggc tttcctggat gcatcctact ccttcattgt ggctcccagg

120

180

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atgctggtgg acttcctttc tgagaagaag gtaatctcct acaggggttg catcactcag 300 ctctttttct tgcacttcct tggaggaggg gaaggattac tccttgttgt gatggccttt 360 gaccgctaca ttgccatctg tcggccttta cactattcaa ctgtcatgaa ccctagagcc 420 tgctatgcct tgctattggc tctgtggctt ggaggctttg tccactccat tatccaggtg 480 gccctcatcc tccgcttgcc cttctgtggc ccaaaccgac tggataactt cttctgtgat 540 gtgccgcagg tcatcaagct ggcctgcaca gacacctttg tggtggagct tctgatggtc 600 ttcaatagtg gtctgctcac tctcctgtgc ttcttggggc tcttgtcttc ctatgcagtc 660 atcctctgcc atgtacatgg gtctgcttgt gaagggaaga gcaaagcagt gtccacgtgt 720 accactcatg tcatgattat acttctcatg tttgggcctg ccatcttcat ctacactcgc 780 cccttcaggg ctttatcagc tgacaaggta gtttccttct ttcacactgt gatctttcct 840 ttgttgaatc ctgtgattta tacccttcgc aaccaagaag tgaaaacttc catgaggagg 900 ttattgagtc ggcatgtggt ctgctga 927

<210> 300 <211> 308 <212> PRT <213> Canis familiaris <400> 300

Met 1 Glu Ala Glu Asn 5 Ser Thr Val Val Lys Glu Phe Ile Leu Leu Gly 10 15 Leu Thr Gln Ser Arg Asn Ile Gln Leu Leu Val Phe Val Leu Val Leu 20 25 30 Ile Phe Tyr Phe Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Leu Thr 35 40 45 Ile Arg Thr Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg 65 70 75 80 Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly

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85 90 95

Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly 100 105 110 Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Ser Thr Val Met Asn Pro Arg Ala Cys Tyr Ala Leu 130 135 140 Leu Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val 145 150 155 160 Ala Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Asn Arg Leu Asp Asn 165 170 175 Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Leu Thr Leu 195 200 205 Leu Cys Phe Leu Gly Leu Leu Ser Ser Tyr Ala Val Ile Leu Cys His 210 215 220 Val His Gly Ser Ala Cys Glu Gly Lys Ser Lys Ala Val Ser Thr Cys 225 230 235 240 Thr Thr His Val Met Ile Ile Leu Leu Met Phe Gly Pro Ala Ile Phe 245 250 255 Ile Tyr Thr Arg Pro Phe Arg Ala Leu Ser Ala Asp Lys Val Val Ser 260 265 270 Phe Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Val Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Thr Ser Met Arg Arg Leu Leu Ser Arg

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290 295 300

His Val Val Cys

305 <210> 301 <211> 993 <212> DNA <213> Canis familiaris <400> 301

atgctcatca ttattcactc attggttatc tctgcttctc taacagcttt ggaatcccag 60 aacacaacaa tgcgttttgt gtctgagttt gtcctcctgg gtttccctgg tcaaagggag 120 atgcagaact ttttcttctc attcatcctg gtgatctatc tcctcaccct gctggggaat 180 gggattattg tctgcatagt gaaatgggac aagcagcttc acacacccat gtacatcttc 240 ttgggaaact ttgccttcct agagatctgg tacacctcct ccactgtccc aagtatgctg 300 gtcaacatcc tttccgagac caagaccatc tccttcactg ggtgcttcct tcaattctac 360 ttctttttct cactgggtac aacagagtgt ttcttcttat cagtcatggc ttatgatcgg 420 tacctcgcca tctgtcgccc actccattac ccctccatca tgactgggaa gctctgtgtg 480 gccctggtct gtgtttgctg ggtgagtgga tttctctgct atccagtccc cattgtcctc 540 atctcccaac ttccattctg tggacccaac atcattgatc actttgtgtg tgacccaggc 600 ccactgttcg cactggcctg catccctgct ccttccactg agcttctctg ttacaccttc 660 aattcactga ttatcttcgg gcccttcctc ttcatcctgg gatcttacac cctggttctc 720 agagctgtgc ttcgcattcc ttctggtgca ggtcgaacta aagcattctc cacgtgtggg 780 tcccatctaa tggtggtgtc tctattctat ggaaccctta tggtgatgta tgtgagcccg 840 acatcaggga atccgacggg aatgcaaaag atcatcactc tggtatactc ggcagtgact 900 ccactcttaa acccccttat ctatagtctc cgaaacaaag acatgaaaga tgccctaaag 960 aaagtcctag gattaagaag taaccaaaac tga 993

<210> 302 <211> 330 <212> PRT <213> Canis familiaris

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069269_0225_SL.TXT <400> 302

Met 1 Leu Ile Ile Ile His Ser Leu Val Ile Ser Ala Ser Leu Thr Ala 5 10 15 Leu Glu Ser Gln Asn Thr Thr Met Arg Phe Val Ser Glu Phe Val Leu 20 25 30 Leu Gly Phe Pro Gly Gln Arg Glu Met Gln Asn Phe Phe Phe Ser Phe 35 40 45 Ile Leu Val Ile Tyr Leu Leu Thr Leu Leu Gly Asn Gly Ile Ile Val 50 55 60 Cys Ile Val Lys Trp Asp Lys Gln Leu His Thr Pro Met Tyr Ile Phe 65 70 75 80 Leu Gly Asn Phe Ala Phe Leu Glu Ile Trp Tyr Thr Ser Ser Thr Val 85 90 95 Pro Ser Met Leu Val Asn Ile Leu Ser Glu Thr Lys Thr Ile Ser Phe 100 105 110 Thr Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr 115 120 125 Glu Cys Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile 130 135 140 Cys Arg Pro Leu His Tyr Pro Ser Ile Met Thr Gly Lys Leu Cys Val 145 150 155 160 Ala Leu Val Cys Val Cys Trp Val Ser Gly Phe Leu Cys Tyr Pro Val 165 170 175 Pro Ile Val Leu Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn Ile Ile 180 185 190 Asp His Phe Val Cys Asp Pro Gly Pro Leu Phe Ala Leu Ala Cys Ile 195 200 205

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Pro Ala Pro Ser Thr Glu Leu Leu Cys Tyr Thr Phe Asn Ser Leu Ile 210 215 220 Ile Phe Gly Pro Phe Leu Phe Ile Leu Gly Ser Tyr Thr Leu Val Leu 225 230 235 240 Arg Ala Val Leu Arg Ile Pro Ser Gly Ala Gly Arg Thr Lys Ala Phe 245 250 255 Ser Thr Cys Gly Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr 260 265 270 Leu Met Val Met Tyr Val Ser Pro Thr Ser Gly Asn Pro Thr Gly Met 275 280 285 Gln Lys Ile Ile Thr Leu Val Tyr Ser Ala Val Thr Pro Leu Leu Asn 290 295 300 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys 305 310 315 320 Lys Val Leu Gly Leu Arg Ser Asn Gln Asn 325 330

<210> 303 <211> 945 <212> DNA <213> Canis familiaris <400> 303

atgaataagt cagagatatc tactgtgaca cagtttgtct tgttgggttt tcctggtccc 60 tggaaaatac agatcatgct tttctcaatg attttgttgg tctatatctt gactctaact 120 gggaatacgg ccatcatttg tgcagtgaga tgggaccatc gactccatac ccctatgtat 180 gtgctcctgg caaacttctc cttcctagaa atctggtatg tgacttgcac cattcccaac 240 atgctggtca atttactttc caaaacaaag accatatcgt tctctggttg cttcgctcag 300 ttctacttct tcttttccct gggcacaact gagtgcttct tcctctgtgt catggcgtat 360

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069269_0225_S L.TXT gataggtacc tggccatctg ccatccactg cactacccct ccattatgac tgggcatctc 420 tgtgtcattc tggtgttgct ttgttggctc attggtttcc ttggacatgg gatcactata 480 ttcttcattt ctcaactacc cttttgtggt cccaacatta ttgaccactt tctgtgtgat 540 gtggacccac tgatcacatt gtcctgtgcc cccgcacaca tcatagagca tgtatcccat 600 tctgtgagct ctcttatcat cattctcacc attttgtaca ttcttgggtc ctatgccctg 660 gtgctcagag ctgtgcttca ggttccttct tcagctggac ggcaaaaggc cttctctacc 720 tgtggatctc acttagttgt ggtgtctctg ttttacggaa ccataatggc aatgtatgta 780 agtcccacat ctggcaactc agttgctatg cataaggtca tcacactgat atactctgta 840 gtgacaccag tcttaaaccc cttcatctac agcctacgca acagggacat gaaattcgcc 900 ctccgtcagg <210> 304 <211> 314 <212> PRT <213> Canis <400> 304 tcatttgtgg aatgaaaatc ctcaaaccct familiaris catga 945 Met Asn Lys 1 Ser Glu Ile Ser Thr Val Thr Gln 5 10 Phe Val Leu Leu Gly 15 Phe Pro Gly Pro Trp Lys Ile Gln Ile Met Leu 20 25 Phe Ser Met 30 Ile Leu Leu Val Tyr 35 Ile Leu Thr Leu Thr Gly Asn Thr 40 Ala Ile Ile 45 Cys Ala Val Arg Trp 50 Asp His Arg Leu His Thr Pro Met 55 Tyr Val Leu 60 Leu Ala Asn Phe Ser 65 Phe Leu Glu Ile Trp Tyr Val Thr 70 75 Cys Thr Ile Pro Asn 80 Met Leu Val Asn Leu Leu Ser Lys Thr Lys Thr 85 90 Ile Ser Phe Ser Gly 95 Cys Phe Ala Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr Glu Cys

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100

069269_0225_SL.TXT 105 110

Phe Phe Leu Cys Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His 115 120 125 Pro Leu His Tyr Pro Ser Ile Met Thr Gly His Leu Cys Val Ile Leu 130 135 140 Val Leu Leu Cys Trp Leu Ile Gly Phe Leu Gly His Gly Ile Thr Ile 145 150 155 160 Phe Phe Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn Ile Ile Asp His 165 170 175 Phe Leu Cys Asp Val Asp Pro Leu Ile Thr Leu Ser Cys Ala Pro Ala 180 185 190 His Ile Ile Glu His Val Ser His Ser Val Ser Ser Leu Ile Ile Ile 195 200 205 Leu Thr Ile Leu Tyr Ile Leu Gly Ser Tyr Ala Leu Val Leu Arg Ala 210 215 220 Val Leu Gln Val Pro Ser Ser Ala Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Val Val Val Ser Leu Phe Tyr Gly Thr Ile Met 245 250 255 Ala Met Tyr Val Ser Pro Thr Ser Gly Asn Ser Val Ala Met His Lys 260 265 270 Val Ile Thr Leu Ile Tyr Ser Val Val Thr Pro Val Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Phe Ala Leu Arg Gln Val 290 295 300

Ile Cys Gly Met Lys Ile Leu Lys Pro Ser

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305

310 <210> 305 <211> 945 <212> DNA <213> Canis familiaris <400> 305

atgaatgtgt caggagtcag cacagtgact gaattcatac tcctgagttt tccgtgctcc 60 agagaggttc agatcctcct cttcctgctg ttctttgtgt cctacatcct gacactgatg 120 gggaatgggg ccattgtctg tgcagtgaag ctggatccca ggcttcacac ccccatgtac 180 cttctgctgg ccaacttctc gttcctggag atctgttaca tcaacaccac cgttcccaat 240 atgttacaga acttcctatc tgagaccaaa accatctctt tcacagcctg tttcttccag 300 ttctacttct tcttctccat gggcatcaat gagaccctct tactgcccct catggctttt 360 gatcggtact tggccatctg ccagcctctc cattatccta tcatcatgaa caaccgcctc 420 tgcatgaacc tggtggccct gtgctgggtc acagccttcc tctgctatcc gatccctatc 480 tattttatca cacagctccc cttctgtggc cccaacgcca ttgaccactt tgtctgtgac 540 cccggtcctc ttctggccct gtcctgcatc cctgcccctg gaattgagct ttcctgttct 600 ctattgagct ctctcattat cttcatcacc ttcttcttca tccttggttc gtacaccctg 660 gttctcagag cagtgttgcg tgtcccctca gcagctggcc gacgtaaggc cttctctacc 720 tgtggttccc acctggctgt tgtgtctctt ttttatggat ccatcatggt tatgtacatc 780 agcccaacct ctgcgaatcc agctgggata cagaagatta taaccctgtt ctactcatca 840 gtgaccccac ttataaaccc actgatctac agtctacgga acaaagacat gaaagctgcc 900 ttgagaaaaa ttcatatgtg cggagaaatt agtcaagaca aatga 945

<210> 306 <211> 314 <212> PRT <213> Canis familiaris <400> 306

Met Asn Val Ser Gly Val Ser Thr Val Thr Glu Phe Ile Leu Leu Ser 1 5 10 15

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Phe Pro Cys Ser 20 Arg Glu Val Gln Ile Leu Leu Phe Leu Leu Phe Phe 25 30 Val Ser Tyr Ile Leu Thr Leu Met Gly Asn Gly Ala Ile Val Cys Ala 35 40 45 Val Lys Leu Asp Pro Arg Leu His Thr Pro Met Tyr Leu Leu Leu Ala 50 55 60 Asn Phe Ser Phe Leu Glu Ile Cys Tyr Ile Asn Thr Thr Val Pro Asn 65 70 75 80 Met Leu Gln Asn Phe Leu Ser Glu Thr Lys Thr Ile Ser Phe Thr Ala 85 90 95 Cys Phe Phe Gln Phe Tyr Phe Phe Phe Ser Met Gly Ile Asn Glu Thr 100 105 110 Leu Leu Leu Pro Leu Met Ala Phe Asp Arg Tyr Leu Ala Ile Cys Gln 115 120 125 Pro Leu His Tyr Pro Ile Ile Met Asn Asn Arg Leu Cys Met Asn Leu 130 135 140 Val Ala Leu Cys Trp Val Thr Ala Phe Leu Cys Tyr Pro Ile Pro Ile 145 150 155 160 Tyr Phe Ile Thr Gln Leu Pro Phe Cys Gly Pro Asn Ala Ile Asp His 165 170 175 Phe Val Cys Asp Pro Gly Pro Leu Leu Ala Leu Ser Cys Ile Pro Ala 180 185 190 Pro Gly Ile Glu Leu Ser Cys Ser Leu Leu Ser Ser Leu Ile Ile Phe 195 200 205 Ile Thr Phe Phe Phe Ile Leu Gly Ser Tyr Thr Leu Val Leu Arg Ala 210 215 220

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Val 225 Leu Arg Val Pro Ser Ala 230 Ala Gly Arg Arg Lys Ala Phe Ser Thr 235 240 Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Ser Ile Met 245 250 255 Val Met Tyr Ile Ser Pro Thr Ser Ala Asn Pro Ala Gly Ile Gln Lys 260 265 270 Ile Ile Thr Leu Phe Tyr Ser Ser Val Thr Pro Leu Ile Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Ala Ala Leu Arg Lys Ile 290 295 300 His Met Cys Gly Glu Ile Ser Gln Asp Lys 305 310

<210> 307 <211> 951 <212> DNA <213> Canis familiaris <400> 307

atgaacaggt cagcgacaca cattcacgtt gtaaccgagt ttgtcctcct gggattcccc 60 ggttgctggg agatacagat tttcctcttc tccttctttt tggtggttta tgtcttgacc 120 ctgctgggaa atggaaccat tatctgtgca gtgagatggg agccgcgatt acacaccccc 180 atgtactttc tgctgggcaa cttcgccttc cttgagatct ggtatgcttc ctccactgtt 240 cccaatgtcc tggccaacat cctctccaaa accaaggcca tctcattttc tggctgcttc 300 ctccagttct acttcttctt ttccctgggc acgactgaat gtctcttcct ggcagtaatg 360 gcttatgatc gttacctggc catctgccac ccactgcact accccaccgt catgactggg 420 aaactctgta gaactctggt gtctctctgc tggctcactg gattccttgg ctacccaatc 480 cccattttcc tcatctcccg actccctttc tgtggatcca atatcattga tcacttcctg 540 tgtgacatgg accccctgat ggccctgtct tgtgctccag cccccattac tgaacttatt 600 ttctacactc agagctccct tgttctcttt tttactatta tgtacattct tcgatcctac 660

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069269_0225_SL.TXT atcttgttac tcagagctgt ttttctggtc ccttctgcag ctggccggag aaaggccttt tccacctgtg gttctcattt agctgtggtg tctctttttt atgggacagt catggtaatg tatgtgagtc ctacatatgg catcccaact ttgatgcaga agattctcac actggtatat tcgataatga cgcctctctt taatccgctg atctatagtc ttcgcaataa ggacatgaaa ctcgccctga gaaacatcct gtttagaatg agaattagtc aaaactcttg a

720

780

840

900

951 <210> 308 <211> 316 <212> PRT <213> Canis familiaris <400> 308

Met Asn Arg Ser 1 Ala 5 Thr His Ile His Val Val Thr Glu Phe Val Leu 10 15 Leu Gly Phe Pro Gly Cys Trp Glu Ile Gln Ile Phe Leu Phe Ser Phe 20 25 30 Phe Leu Val Val Tyr Val Leu Thr Leu Leu Gly Asn Gly Thr Ile Ile 35 40 45 Cys Ala Val Arg Trp Glu Pro Arg Leu His Thr Pro Met Tyr Phe Leu 50 55 60 Leu Gly Asn Phe Ala Phe Leu Glu Ile Trp Tyr Ala Ser Ser Thr Val 65 70 75 80 Pro Asn Val Leu Ala Asn Ile Leu Ser Lys Thr Lys Ala Ile Ser Phe 85 90 95 Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr 100 105 110 Glu Cys Leu Phe Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile 115 120 125 Cys His Pro Leu His Tyr Pro Thr Val Met Thr Gly Lys Leu Cys Arg 130 135 140

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Thr 145 Leu Val Ser Leu Cys Trp Leu Thr Gly Phe Leu Gly Tyr Pro Ile 150 155 160 Pro Ile Phe Leu Ile Ser Arg Leu Pro Phe Cys Gly Ser Asn Ile Ile 165 170 175 Asp His Phe Leu Cys Asp Met Asp Pro Leu Met Ala Leu Ser Cys Ala 180 185 190 Pro Ala Pro Ile Thr Glu Leu Ile Phe Tyr Thr Gln Ser Ser Leu Val 195 200 205 Leu Phe Phe Thr Ile Met Tyr Ile Leu Arg Ser Tyr Ile Leu Leu Leu 210 215 220 Arg Ala Val Phe Leu Val Pro Ser Ala Ala Gly Arg Arg Lys Ala Phe 225 230 235 240 Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr 245 250 255 Val Met Val Met Tyr Val Ser Pro Thr Tyr Gly Ile Pro Thr Leu Met 260 265 270 Gln Lys Ile Leu Thr Leu Val Tyr Ser Ile Met Thr Pro Leu Phe Asn 275 280 285 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Leu Ala Leu Arg 290 295 300 Asn Ile Leu Phe Arg Met Arg Ile Ser Gln Asn Ser

305 310 315 <210> 309 <211> 996 <212> DNA <213> Canis familiaris <400> 309 atggctcctg gcgagaacca gagcagcggt gtgaccgagt tcatcttggc aggcttccca Page 345

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aatctcaaca acacaaaagc agaagtgttc tctgtcttcc ttcttgtcta cctgctgact 120 ctaacaggca acgtgctgat tgttggggtg gtgggagcgg atgctcgcct gcagaccccc 180 atgtacttct tcctgggcaa cctgtcctgc ctcgagatct tgctcacttc cgtcatcatt 240 cccaagatgc tgagcaattt cctttccagg caacacacca tctcctttgc tgcatgcatt 300 actcaattct atttctactt ctttcttggg gcctctgagt tcctgctgtt ggccgtcatg 360 tctgtggatc gctacctggc catctgtcac cctctgcact atcccttgct catgaatggt 420 gctgtgtgct ctcgggtggc cttggcctgc tggatggggg gacttgtccc tgtgcttggc 480 cccacggtgg ctgtggcctt acttcccttc tgtgaacagc acactgtggt gcagcatttc 540 ttctgtgaca gtggccctct gctccgcctg gcatgcacca acaccaagaa gctggaggaa 600 acagacttcg tgctggcctc tctggtcatc atatcctcgc tgatgattac tgctgtgtcc 660 tatggccaca tagctctggc tgtcctgcgc attccctctg tttccggccg tcagaaggcc 720 ttctctacct gtacctctca cttgatggtg gtgaccctct tctatggaag tgccattttt 780 ctctatgtgc gaccatcaca gagtggctct gtgaatacca actgggcagt gacagtggta 840 acaacgtttg tgacaccgct gctgaatcca ttcatctatg ccttacgcaa tgagcgagtc 900 aaggaagctt tgaaggatat gttcaggaag atgggagtag gcttttgggg gaatcttcta 960 ctcactaaga atttcagtaa gaagacagtg aagtga 996

<210> 310 <211> 331 <212> PRT <213> Canis familiaris <400> 310

Met 1 Ala Pro Gly Glu Asn Gln Ser Ser Gly Val Thr Glu Phe Ile Leu 5 10 15 Ala Gly Phe Pro Asn Leu Asn Asn Thr Lys Ala Glu Val Phe Ser Val 20 25 30 Phe Leu Leu Val Tyr Leu Leu Thr Leu Thr Gly Asn Val Leu Ile Val 35 40 45

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Gly Val 50 Val Gly Ala Asp Ala 55 069269_0225_SL.TXT Arg Leu Gln Thr Pro Met 60 Tyr Phe Phe Leu Gly Asn Leu Ser Cys Leu Glu Ile Leu Leu Thr Ser Val Ile Ile 65 70 75 80 Pro Lys Met Leu Ser Asn Phe Leu Ser Arg Gln His Thr Ile Ser Phe 85 90 95 Ala Ala Cys Ile Thr Gln Phe Tyr Phe Tyr Phe Phe Leu Gly Ala Ser 100 105 110 Glu Phe Leu Leu Leu Ala Val Met Ser Val Asp Arg Tyr Leu Ala Ile 115 120 125 Cys His Pro Leu His Tyr Pro Leu Leu Met Asn Gly Ala Val Cys Ser 130 135 140 Arg Val Ala Leu Ala Cys Trp Met Gly Gly Leu Val Pro Val Leu Gly 145 150 155 160 Pro Thr Val Ala Val Ala Leu Leu Pro Phe Cys Glu Gln His Thr Val 165 170 175 Val Gln His Phe Phe Cys Asp Ser Gly Pro Leu Leu Arg Leu Ala Cys 180 185 190 Thr Asn Thr Lys Lys Leu Glu Glu Thr Asp Phe Val Leu Ala Ser Leu 195 200 205 Val Ile Ile Ser Ser Leu Met Ile Thr Ala Val Ser Tyr Gly His Ile 210 215 220 Ala Leu Ala Val Leu Arg Ile Pro Ser Val Ser Gly Arg Gln Lys Ala 225 230 235 240 Phe Ser Thr Cys Thr Ser His Leu Met Val Val Thr Leu Phe Tyr Gly 245 250 255

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Ser Ala Ile Phe Leu 260 Tyr Val Arg Pro Ser 265 Gln Ser Gly Ser 270 Val Asn Thr Asn Trp Ala Val Thr Val Val Thr Thr Phe Val Thr Pro Leu Leu 275 280 285 Asn Pro Phe Ile Tyr Ala Leu Arg Asn Glu Arg Val Lys Glu Ala Leu 290 295 300 Lys Asp Met Phe Arg Lys Met Gly Val Gly Phe Trp Gly Asn Leu Leu 305 310 315 320 Leu Thr Lys Asn Phe Ser Lys Lys Thr Val Lys 325 330

<210> 311 <211> 948 <212> DNA <213> Canis familiaris <400> 311

atgaaaaaaa gcaatgattc taaggtgaca gaatttgttc ttctgggcct atcatcctcc 60 tgggagctac agctgtttct cttcttcata tttttattgt tttacatgac tgttattctg 120 ggaaacctgt tgataatggt aacagtgcga gctgatgctc acctgctcca atctcccatg 180 tactattttt tgggtcatct gtctttcatt gacctatgcc taggctgtgt taccgtgccc 240 aagatgttaa gagattttct acaacaagga aagatcatct ctttttcagg atgtttgacc 300 cagatctact tcctgcactt tctgggagcc aatgagacat ttctgttgac ggtcatggcc 360 tatgataggt atgtggccat atgtaatccc ttgcactacc tgacagtcat gaaccgccag 420 ctgtgctttc agttggtttt tacctgttgg tttgggggtt tcatccactc tatatcacag 480 gtcacactgg taatccagct gcccttctgt ggccccaatg aactggacaa cttctactgt 540 gacgtccctc aggtcatcaa gctcgcgtgc atggatacat atgtagtaga ggtgctcatg 600 gtctcaaaca gtggtcttct ctctctcatc tgcttctttg tcttgctgtt ctcttacgcc 660 atcatcctga ccactctgag aactcgcttc caccagggcc ggagcaaggc actctctacc 720 tgtgcctctc acctaacagt ggtcagcctg atctttgtgc catgtgtatt catctacctg 780

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069269_0225_SL.TXT agacctttct gcagcttctc cgtggataag atattctctg tcttttacac agtgatcaca cctatgttga acccgcttat ctacacactc agaaatgctg acatgaagag agccatgaaa aagctaagaa aaaagtatgc ggcattcttc ttccatagta aaggatga

840

900

948 <210> 312 <211> 315 <212> PRT <213> Canis familiaris <400> 312

Met 1 Lys Lys Ser Asn 5 Asp Ser Lys Val Thr Glu Phe Val Leu Leu Gly 10 15 Leu Ser Ser Ser Trp Glu Leu Gln Leu Phe Leu Phe Phe Ile Phe Leu 20 25 30 Leu Phe Tyr Met Thr Val Ile Leu Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Arg Ala Asp Ala His Leu Leu Gln Ser Pro Met Tyr Tyr Phe Leu 50 55 60 Gly His Leu Ser Phe Ile Asp Leu Cys Leu Gly Cys Val Thr Val Pro 65 70 75 80 Lys Met Leu Arg Asp Phe Leu Gln Gln Gly Lys Ile Ile Ser Phe Ser 85 90 95 Gly Cys Leu Thr Gln Ile Tyr Phe Leu His Phe Leu Gly Ala Asn Glu 100 105 110 Thr Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu His Tyr Leu Thr Val Met Asn Arg Gln Leu Cys Phe Gln 130 135 140 Leu Val Phe Thr Cys Trp Phe Gly Gly Phe Ile His Ser Ile Ser Gln 145 150 155 160

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Val Thr Leu Val Ile Gln Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp 165 170 175 Asn Phe Tyr Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Met Asp 180 185 190 Thr Tyr Val Val Glu Val Leu Met Val Ser Asn Ser Gly Leu Leu Ser 195 200 205 Leu Ile Cys Phe Phe Val Leu Leu Phe Ser Tyr Ala Ile Ile Leu Thr 210 215 220 Thr Leu Arg Thr Arg Phe His Gln Gly Arg Ser Lys Ala Leu Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ser Leu Ile Phe Val Pro Cys Val 245 250 255 Phe Ile Tyr Leu Arg Pro Phe Cys Ser Phe Ser Val Asp Lys Ile Phe 260 265 270 Ser Val Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Thr Leu Arg Asn Ala Asp Met Lys Arg Ala Met Lys Lys Leu Arg Lys 290 295 300 Lys Tyr Ala Ala Phe Phe Phe His Ser Lys Gly 305 310 315

<210> 313 <211> 930 <212> DNA <213> Canis familiaris <400> 313 atggaagtgg ctaacaatgt cactgagttt atattcctag gcctctccca ggatcctgga atgcagttga tgttctttgc cttgttcctc ttcttctaca tcgtgatcat ggtgggaaac ctgctcattc tacttacggt cttctctgat ccccggctcc acacacccat gtatttcttc Page 350

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069269_0225_SL.TXT ctcagtaacc tgtcctttgt ggacattgcc gcagactttg tttctgagaa aaagaccatt accttccact tttttggttg tgctgagatt tatgctgcca tctgccagcc tctccgttat atgctggcat cactgtcctg gctgggagcg acctttcagc tgcctttctg ccataatcag ccagtcctaa agcttgcctg tgctgataca agtggtctca tctctttagg gtgcttcctc tttagtcttc gcaagaggtc ttcagagagc catttcactg tagtaacgtt cttctttgtc actactttcc ccctggataa ggctgtgtct aacccgctca tctacactct gaggaatgag aataacatgg tctccttgaa ggaaaagtaa <210> 314 <211> 309 <212> PRT <213> Canis familiaris <400> 314

Met Glu Val Ala Asn Asn Val Thr 1 5 Gln Asp Pro Gly Met Gln Leu Met 20 Tyr Ile Val Ile Met Val Gly Asn 35 40 Ser Asp Pro Arg Leu His Thr Pro 50 55 Ser Phe Val Asp Ile Ala Tyr Ser 65 70

Glu Phe 10 Ile Phe Leu Gly Leu 15 Ser Phe 25 Phe Ala Leu Phe Leu 30 Phe Phe Leu Leu Ile Leu Leu 45 Thr Val Phe Met Tyr Phe Phe 60 Leu Ser Asn Leu Ser Ala Thr 75 Ala Pro Lys Met Ile 80

tattcctcag ccacagcacc caagatgatt tcctactggg gctgtgtaac tcagatgttt tttgtcttga ctgttatggc ttttgaccgt acgaccatca tgagtgccaa tgcttgtatc ctgggtcatt cctttgttca gaccctcctg gtcattgacc actacttctg tgatgtccac accctggtaa atatgttggt gattgccaac attcttctgg cctcctacac tgtcattctc cggcgcaagg ctctttctac ctgtgggtct ccttgtatct ttatttacct ccgtccatcc gtgttctata ctaccatcac cccaatgctg gatgtaaaga atgccatgaa acgcatatgg

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Ala Asp Phe Val Ser 85 Glu Lys Lys Thr Ile Ser Tyr Trp Gly Cys Val 90 95 Thr Gln Met Phe Thr Phe His Phe Phe Gly Cys Ala Glu Ile Phe Val 100 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Gln Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Ser Ala Asn Ala Cys Ile Met Leu Ala Ser 130 135 140 Leu Ser Trp Leu Gly Ala Leu Gly His Ser Phe Val Gln Thr Leu Leu 145 150 155 160 Thr Phe Gln Leu Pro Phe Cys His Asn Gln Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Val His Pro Val Leu Lys Leu Ala Cys Ala Asp Thr Thr Leu 180 185 190 Val Asn Met Leu Val Ile Ala Asn Ser Gly Leu Ile Ser Leu Gly Cys 195 200 205 Phe Leu Ile Leu Leu Ala Ser Tyr Thr Val Ile Leu Phe Ser Leu Arg 210 215 220 Lys Arg Ser Ser Glu Ser Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Phe Thr Val Val Thr Phe Phe Phe Val Pro Cys Ile Phe Ile Tyr 245 250 255 Leu Arg Pro Ser Thr Thr Phe Pro Leu Asp Lys Ala Val Ser Val Phe 260 265 270 Tyr Thr Thr Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285

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Asn Glu Asp Val Lys Asn Ala Met Lys Arg Ile Trp Asn Asn Met Val 290 295 300

Ser Leu Lys Glu Lys

305 <210> 315 <211> 951 <212> DNA <213> Canis familiaris <400> 315 atggaacctg caaattacac tagggtgacg gaatttgttc tcactggctt atcccagact 60 cgagaggtac aactagtcct atttgttata tttctgtcct tctatctgtt catcctccca 120 ggaaatgttc ttattatttg caccatcagg ctggaccctc acctgacctc acccatgtat 180 ttcctgctgg ctaacctggc cttccttgac atttggtact cctccatcac ggcccctaaa 240 atgctcgtag acttctttgt ggaaagaaag aggatttctt tcggtgggtg cattgcacag 300 ctcttctttt tgcacttcgt tggggcctcc gagatgttcc tgctcacagt aatggccttt 360 gaccgctatg ctgctatctg ccgccctctc cactatgcta ctatcatgaa tcgacgtctc 420 tgctgtatcc tggtggctct ctcctggttg gggggcttca ttcattctat aatacaagtg 480 gtcctcatcg tccgacttcc cttctgcggg cccaatgagt tagacagtta cttctgtgat 540 atcacgcagg tcgtccgcat tgcctgtgcc aataccttcc ccgaggagtt agtgatgatt 600 tttagcagtg gtctgatctc tgtagtatgc ttcattgctc tcctaatgtc ctatgccttc 660 ctcctggcca tgttgaggaa acactcaggc tcaggtgaga gtaccagtcg ggccatgtcc 720 acctgctatt cccacatcac gattgtggtg ttcatgtttg gaccatctat ctacatttat 780 gctcgaccat ttgactcgtt ttccctcgat aaggttgtgt ctgtgttcca tactgtgata 840 ttccctttac ttaatcccat tatctacacc ttgagaaata aagaagtaaa gacggccatg 900 aggaagttgg tcaacagata tattttatgt agagaagtga aagataagtg a 951 <210> 316 <211> 316 <212> PRT

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069269_0225_SL.TXT <213> Canis familiaris <400> 316

Met Glu Pro Ala Asn Tyr Thr Arg Val Thr Glu Phe Val Leu Thr Gly 1 5 10 15 Leu Ser Gln Thr Arg Glu Val Gln Leu Val Leu Phe Val Ile Phe Leu 20 25 30 Ser Phe Tyr Leu Phe Ile Leu Pro Gly Asn Val Leu Ile Ile Cys Thr 35 40 45 Ile Arg Leu Asp Pro His Leu Thr Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ala Phe Leu Asp Ile Trp Tyr Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Met Leu Val Asp Phe Phe Val Glu Arg Lys Arg Ile Ser Phe Gly Gly 85 90 95 Cys Ile Ala Gln Leu Phe Phe Leu His Phe Val Gly Ala Ser Glu Met 100 105 110 Phe Leu Leu Thr Val Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Ala Thr Ile Met Asn Arg Arg Leu Cys Cys Ile Leu 130 135 140 Val Ala Leu Ser Trp Leu Gly Gly Phe Ile His Ser Ile Ile Gln Val 145 150 155 160 Val Leu Ile Val Arg Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp Ser 165 170 175 Tyr Phe Cys Asp Ile Thr Gln Val Val Arg Ile Ala Cys Ala Asn Thr 180 185 190 Phe Pro Glu Glu Leu Val Met Ile Phe Ser Ser Gly Leu Ile Ser Val

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195 200 205 Val Cys Phe Ile Ala Leu Leu Met Ser Tyr Ala Phe Leu Leu Ala Met 210 215 220 Leu Arg Lys His Ser Gly Ser Gly Glu Ser Thr Ser Arg Ala Met Ser 225 230 235 240 Thr Cys Tyr Ser His Ile Thr Ile Val Val Phe Met Phe Gly Pro Ser 245 250 255 Ile Tyr Ile Tyr Ala Arg Pro Phe Asp Ser Phe Ser Leu Asp Lys Val 260 265 270 Val Ser Val Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Ile Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Glu Val Lys Thr Ala Met Arg Lys Leu Val 290 295 300 Asn Arg Tyr Ile Leu Cys Arg Glu Val Lys Asp Lys

305 310 315 <210> 317 <211> 948 <212> DNA <213> Canis familiaris <400> 317

atgaaaaaaa gcaatgattc taaggtgaca gaatttgttc ttctgggcct atcatcctcc 60 tgggagctac agctgtttct cttcttcata tttttattgt tttacatgac tgttgttctg 120 ggaaacctgt tgataatggt aacagtacga gctgatgctc acctgctcca atctcccatg 180 tactattttt tgggtcatct gtctttcatt gacctatgcc tgggctgtgt taccgtgccc 240 aagatgttaa gagattttct acaacgaggc aagatcatct ctttctcagg atgtttggcc 300 cagatctact tcctgcactt tctgggagcc agtgagatgt ttctgttgac ggtcatggcc 360 tatgataggt atgtggccat atgtaatccc ttgcactacc tgacagtcat gaaccgccag 420 ttatgctttc agttggtttt tgcctgttgg tgtgggggtt tcatccactc tatcacacag 480

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gtcatgctgg tgatccagct gcccttctgt ggccccaatg aactggacaa cttctactgt 540 gacgtccctc aggtcatcaa gctcgcgtgc atggatacat atgtagtaga ggtgctcatg 600 gtctcaaaca gtggtctgct ctctctcatc tgtttcttgg tcttgctgtt ctcttacgcc 660 atcatcctga ccactctgag aactcgcttc cgccagggcc ggagcaaggc actctctacc 720 tgtgcctctc acctaacagt ggtcagcctg atctttgtgc catgtgtatt catctacctg 780 agacctttct gcagcttctc tgtggataag gttttctctg tcttttacac agtgatcaca 840 cctatgttga accctcttat ctacacactc agaaatgctg acatgaagac agccatgaaa 900 aagctaagaa aaaagtatgc agcatccttc ttccatagta aaggatga 948

<210> 318 <211> 315 <212> PRT <213> Canis familiaris <400> 318

Met 1 Lys Lys Ser Asn Asp Ser Lys Val Thr Glu Phe Val Leu Leu Gly 5 10 15 Leu Ser Ser Ser Trp Glu Leu Gln Leu Phe Leu Phe Phe Ile Phe Leu 20 25 30 Leu Phe Tyr Met Thr Val Val Leu Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Arg Ala Asp Ala His Leu Leu Gln Ser Pro Met Tyr Tyr Phe Leu 50 55 60 Gly His Leu Ser Phe Ile Asp Leu Cys Leu Gly Cys Val Thr Val Pro 65 70 75 80 Lys Met Leu Arg Asp Phe Leu Gln Arg Gly Lys Ile Ile Ser Phe Ser 85 90 95 Gly Cys Leu Ala Gln Ile Tyr Phe Leu His Phe Leu Gly Ala Ser Glu 100 105 110

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Met Phe Leu 115 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 120 125 Asn Pro Leu His Tyr Leu Thr Val Met Asn Arg Gln Leu Cys Phe Gln 130 135 140 Leu Val Phe Ala Cys Trp Cys Gly Gly Phe Ile His Ser Ile Thr Gln 145 150 155 160 Val Met Leu Val Ile Gln Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp 165 170 175 Asn Phe Tyr Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Met Asp 180 185 190 Thr Tyr Val Val Glu Val Leu Met Val Ser Asn Ser Gly Leu Leu Ser 195 200 205 Leu Ile Cys Phe Leu Val Leu Leu Phe Ser Tyr Ala Ile Ile Leu Thr 210 215 220 Thr Leu Arg Thr Arg Phe Arg Gln Gly Arg Ser Lys Ala Leu Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ser Leu Ile Phe Val Pro Cys Val 245 250 255 Phe Ile Tyr Leu Arg Pro Phe Cys Ser Phe Ser Val Asp Lys Val Phe 260 265 270 Ser Val Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Thr Leu Arg Asn Ala Asp Met Lys Thr Ala Met Lys Lys Leu Arg Lys 290 295 300 Lys Tyr Ala Ala Ser Phe Phe His Ser Lys Gly 305 310 315

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069269_0225_SL.TXT <210> 319 <211> 744 <212> DNA <213> Canis familiaris <400> 319 atcctgactc tcatgggaaa tggagctatt attggtgctg tgtgttggga ccagcatctc 60 cacaccccca tgtagatcct gctggggaat tttgcattcc tggagatctg gtatgtcaat 120 ctcactgttg caaacacact gatcaacttc ctttcagact tcttttccat gggctccact 180 gagtgcttct ttctctcagc aatggccttt gattgctact ctgccatctg ccatcctctg 240 tattatgcca caattatgtc tggacaacgt tgtttcaact tagtgatctc ttgttgggcc 300 tgtggctttc tctgctatct ggtacctgtt atcctcatct cccaactgcc tttctgtggt 360 cctaatgcaa ttgatcattt tgtatgtgac tcaggcccat tgctgaccct ttcatgtgct 420 cctgtcccta tgtccaagct catcagctgt accctaagct ccctcaacat cctccttagc 480 ttctttttca tcctcatctc ctgtgccctg gttctacttg ctgtgcttcg gttgccctca 540 gcatccatta ggcataaggc tttttcagtg tgtgggtccc atttgtcaat ggtgttgcta 600 ttctacagga ccattatggt gatgcatgag agccctggat cccaccactc tgccctgatg 660 ccaaagatca tgaccttgtt ctatgcaatg ataactccat tcttcaacct tttgatttac 720 agtctcagga ataaggagat gaaa 744 <210> 320 <211> 192 <212> PRT <213> Canis familiaris <400> 320

Met 1 Gly Ser Thr Glu Cys Phe Phe Leu Ser Ala Met Ala Phe Asp Cys 5 10 15 Tyr Ser Ala Ile Cys His Pro Leu Tyr Tyr Ala Thr Ile Met Ser Gly 20 25 30 Gln Arg Cys Phe Asn Leu Val Ile Ser Cys Trp Ala Cys Gly Phe Leu 35 40 45 Cys Tyr Leu Val Pro Val Ile Leu Ile Ser Gln Leu Pro Phe Cys Gly

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50 55 60

Pro Asn Ala Ile Asp His Phe Val Cys Asp Ser Gly Pro Leu Leu Thr 65 70 75 80 Leu Ser Cys Ala Pro Val Pro Met Ser Lys Leu Ile Ser Cys Thr Leu 85 90 95 Ser Ser Leu Asn Ile Leu Leu Ser Phe Phe Phe Ile Leu Ile Ser Cys 100 105 110 Ala Leu Val Leu Leu Ala Val Leu Arg Leu Pro Ser Ala Ser Ile Arg 115 120 125 His Lys Ala Phe Ser Val Cys Gly Ser His Leu Ser Met Val Leu Leu 130 135 140 Phe Tyr Arg Thr Ile Met Val Met His Glu Ser Pro Gly Ser His His 145 150 155 160 Ser Ala Leu Met Pro Lys Ile Met Thr Leu Phe Tyr Ala Met Ile Thr 165 170 175 Pro Phe Phe Asn Leu Leu Ile Tyr Ser Leu Arg Asn Lys Glu Met Lys 180 185 190

<210> 321 <211> 870 <212> DNA <213> Canis familiaris <400> 321 atgcagctga tgttctttgc cttgttcctc ttcttctaca tcgtgatcat ggtgggaaac ctgctcattc tacttatggt cttctctgat ccccggctcc acacacccat gtatttcttc ctcagtaacc cgtcctttgt ggacattgcc tattcctcag ccacagcacc caagatgatt gcagactttg tttctgagaa aaagaccatt tcctactggg gctgtgtaac tcagatgttt accttccact tttttggttg tgctgagatt tttgtcttga ctgttatggc ttttgaccgt tatgctgcca tctgccagcc tctccgttat acgaccatca tgagtgccaa tgcttgtatc Page 359

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069269_0225_SL.TXT

gtgctggcat cactgtcctg gctgggagtg ctgggtcatt cctttgttca gaccctcctg 420 acctttcagc tgcctttctg ccataatcag gtcattgacc actacctctg tgatgtccac 480 ccagtcctaa aacttgcctg tgctgataca accctggtaa atatgttggt gattgtcaac 540 agtggtctca ttgctctagg gtgcttcctc attcttctgg cctcctacac tgtcattctc 600 tttagtcttc gcaagaggtc ttcagagagc cggcgcaagg ctctttctac ctgcgggtct 660 catttcactg tagtaatgtt cttctttgtc ccttgtttct ttatttacct ccgaccatcc 720 accactttcc ccctggataa ggctgtgtct gtgttctata ctaccatcac cccaatgctg 780 aacccgctca tctatactct gaggaatgag gatgtaaaga atgccatgaa acagatatgg 840 agtcacatgg tctccttgaa ggaaaagtag 870

<210> 322 <211> 289 <212> PRT <213> Canis familiaris <400> 322

Met Gln Leu Met Phe Phe Ala Leu Phe Leu Phe Phe Tyr Ile Val Ile 1 5 10 15 Met Val Gly Asn Leu Leu Ile Leu Leu Met Val Phe Ser Asp Pro Arg 20 25 30 Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Pro Ser Phe Val Asp 35 40 45 Ile Ala Tyr Ser Ser Ala Thr Ala Pro Lys Met Ile Ala Asp Phe Val 50 55 60 Ser Glu Lys Lys Thr Ile Ser Tyr Trp Gly Cys Val Thr Gln Met Phe 65 70 75 80 Thr Phe His Phe Phe Gly Cys Ala Glu Ile Phe Val Leu Thr Val Met 85 90 95 Ala Phe Asp Arg Tyr Ala Ala Ile Cys Gln Pro Leu Arg Tyr Thr Thr 100 105 110

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Ile Met Ser Ala Asn Ala Cys Ile 120 Val Leu Ala Ser Leu 125 Ser Trp Leu 115 Gly Val Leu Gly His Ser Phe Val Gln Thr Leu Leu Thr Phe Gln Leu 130 135 140 Pro Phe Cys His Asn Gln Val Ile Asp His Tyr Leu Cys Asp Val His 145 150 155 160 Pro Val Leu Lys Leu Ala Cys Ala Asp Thr Thr Leu Val Asn Met Leu 165 170 175 Val Ile Val Asn Ser Gly Leu Ile Ala Leu Gly Cys Phe Leu Ile Leu 180 185 190 Leu Ala Ser Tyr Thr Val Ile Leu Phe Ser Leu Arg Lys Arg Ser Ser 195 200 205 Glu Ser Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser His Phe Thr Val 210 215 220 Val Met Phe Phe Phe Val Pro Cys Phe Phe Ile Tyr Leu Arg Pro Ser 225 230 235 240 Thr Thr Phe Pro Leu Asp Lys Ala Val Ser Val Phe Tyr Thr Thr Ile 245 250 255 Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Glu Asp Val 260 265 270 Lys Asn Ala Met Lys Gln Ile Trp Ser His Met Val Ser Leu Lys Glu 275 280 285

Lys <210> 323 <211> 993

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069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 323

atgactgacc cagtgaatgt ctctgagcca tattccagct tcgcttctgt aagagaattt 60 atactcctag gtttctcttg tgagtggaag attcagatcc tcctcttctc actcttcact 120 acaacgtata ctttgacggt aacagggaat ggggccattg tttgtgctat ttggtgtgaa 180 gggagactcc atagccccat gtacatgttc ctggggaatt tctcctttct agagatctgg 240 tatgtctctt ctacagtccc caatatgttg gccaatttcc tctcagaaaa aaagaccatc 300 tcctttactg gatgtttcgt ccaattttat ttctttttct ctttgggaac ttctgaatgt 360 ttgctcttgg ccatcatggc ctttgatcgg taccttgcta tctgccgtcc cttgcactac 420 cctaatatca tgactaggta tttatctacc aaactggtca ttatctgctg ggtttgtggt 480 tttctgttgt tcctgatccc cattgcattc atctctcaga tgcccttctg tggtccaaac 540 attattgacc atgttgtgtg tgacccaggg ccactgtttg cattggcatg tgcatctgcc 600 ccaacaatcc aacagctttg ctatagtcta agctcattag ttatctttgg taacttcctt 660 ttcatccttg ggtcctatac acttgtcctg ttagctgtgt tgcacatgcc ttcaaccctc 720 gggagacata aggccttctc tacctgtggt tctcatttgg ctgtggtatc actattctat 780 ggctctctga tgatcatgta tgtgagccca ggacttgggc attctgcagg tatacagaaa 840 gttgcaactt tgttctatgc tatggtaact ccactcttca acccgctcat ctatagcctc 900 cggaataagg agataaaggc agccctgagg aaagttctgg ggcgttgcta catgacccaa 960 gatgtactat gtgattgctc caggtcagta tag 993

<210> 324 <211> 330 <212> PRT <213> Canis familiaris <400> 324

Met Thr Asp Pro Val Asn Val Ser Glu Pro Tyr Ser Ser Phe Ala Ser

1 5 10 15

Val Arg Glu Phe Ile Leu Leu Gly Phe Ser Cys Glu Trp Lys Ile Gln

20 25 30

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Ile Leu

Gly Asn 50

Ser Pro 65

Tyr Val

Leu Phe 35

Gly Ala

Met Tyr

Ser Ser

Lys Lys

Thr Ile 100

Phe Ser

Leu Gly 115

Asp Arg 130

Tyr Leu

Thr Arg 145

Tyr Leu

Phe Leu

Leu Phe

Cys Gly

Pro Asn 180

Phe Ala

Leu Ala 195

Ser Leu 210

Ser Ser

Ser Tyr 225

Thr Leu

Ser

Ile

Met

Thr

Ser

Thr

Ala

Ser

Leu

165

Ile

Cys

Leu

Val

Leu Phe

Val Cys 55

Phe Leu 70

Val Pro

Phe Thr

Ser Glu

Ile Cys 135

Thr Lys 150

Ile Pro

Ile Asp

Ala Ser

Val Ile 215

Leu Leu 230

Thr Thr 40

Thr Tyr

Thr Leu 45

Thr

Ala Ile Trp Cys Glu Gly Arg 60

Gly Asn Phe Ser Phe Leu Glu 75

Asn Met Leu Ala Asn Phe Leu 90

Gly Cys Phe Val Gln Phe Tyr 105 110

Cys Leu Leu Leu Ala Ile Met 120 125

Arg Pro Leu His Tyr Pro Asn 140

Leu Val Ile Ile Cys Trp Val 155

Ile Ala Phe Ile Ser Gln Met 170

His Val Val Cys Asp Pro Gly 185 190

Ala Pro Thr Ile Gln Gln Leu 200 205

Phe Gly Asn Phe Leu Phe Ile 220

Ala Val Leu His Met Pro Ser 235

Val Thr

Leu His

Ile Trp 80

Ser Glu 95

Phe Phe

Ala Phe

Ile Met

Cys Gly 160

Pro Phe 175

Pro Leu

Cys Tyr

Leu Gly

Thr Leu 240

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Gly Arg His Lys Ala 245 Phe Ser Thr Cys Gly Ser His Leu Ala Val Val 250 255 Ser Leu Phe Tyr Gly Ser Leu Met Ile Met Tyr Val Ser Pro Gly Leu 260 265 270 Gly His Ser Ala Gly Ile Gln Lys Val Ala Thr Leu Phe Tyr Ala Met 275 280 285 Val Thr Pro Leu Phe Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu 290 295 300 Ile Lys Ala Ala Leu Arg Lys Val Leu Gly Arg Cys Tyr Met Thr Gln 305 310 315 320 Asp Val Leu Cys Asp Cys Ser Arg Ser Val 325 330

<210> 325 <211> 927 <212> DNA <213> Canis familiaris <400> 325

atggaggctc cgaatcaaac aagagtgact gagtttgtct tcttggggct cacagataac 60 tgggcgctgg ggacgctact ttttgtggca ttctccctgg cttatgtgct cacccttctg 120 gggaacactc tcatcatagt gaccacggcc cttacccggc gcctccatac ccccatgtac 180 ttcttcctga gcaacctgtc cttcattgac acctgccact cctcggtcac tgtgcccaag 240 atgctggagg gcctgcttag ggagagaaag actatttcct ttgatgactg cattgcgcag 300 ctcttcttcc tacacctgtt cgcttgtgct gagatccttc tgctgaccgt catggcttac 360 gaccgctacg tggccatctg tgccccgctg cgctacccca acgtgatgag catccgggtg 420 tgtgtgcagc tcgtcctcgc cctctggtgg gggggtaccg ttcactctct ggtgcagacc 480 ctcctgacca ttcgtttgcc ctactgcggc cccaacgtta tcgatagcta cttctgcgat 540 gtgccccccg tcatcaagct ggcctgcacg gacacctacc tcacgggagt gctcattgtc 600 tccaacagtg gaaccatctc cctcacctgt ttcctggctt tggtcacctc ttacacaatc 660

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069269_0225_SL.TXT atcctggtgt ctcttagaaa tcagcccact tcatggtggt ccagacacca gcttctccat ttgctaaatc ccctcattta ctcagacaga aacaggtttt <210> 326 <211> 308 <212> PRT <213> Canis familiaris <400> 326

Met 1 Glu Ala Pro Asn 5 Gln Leu Thr Asp Asn 20 Trp Ala Leu Ala Tyr 35 Val Leu Thr Thr Ala 50 Leu Thr Arg Arg

acagtctgct gaagggcgcc cgccttcttc tttggaccat cgacaaggtg gtatctgtct caccttgagg aatgaggagg ctcataa

Thr Arg Val Thr Glu 10

Leu Gly Thr Leu Leu 25

Leu Leu Gly Asn Thr 40

Leu His Thr Pro Met 55 ggaaagctct gtctacgtgc gcatcttcat ctacactcgg tctacaccgt ggtcacccct taaaaagtgc cataaagcat

720

780

840

900

927

Asn

Leu Ser Phe Ile Asp Thr Cys His 70

Met

Leu Glu Gly Leu 85

Cys

Ile Ala Gln Leu 100

Leu

Phe Val Phe Leu Gly 15

Phe Val Ala Phe Ser 30

Leu Ile Ile Val Thr 45

Tyr Phe Phe Leu Ser 60

Ser Ser Val Thr Val 75

Leu Arg Glu Arg Lys 90

Phe Phe

Leu His 105

Leu

Leu Leu Thr Val Met Ala 115

Pro Lys 80

Thr Ile Ser Phe Asp Asp 95

Phe Ala Cys Ala Glu 110

Tyr Asp Arg Tyr Val Ala 120 125

Pro Leu Arg Tyr Pro Asn Val Met 130 135

Ser

Ile Arg Val 140

Ile

Ile Cys Ala

Cys Val Gln Leu

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Val 145 Leu Ala Leu Trp Trp 150 Gly Gly Thr Val His Ser Leu Val Gln Thr 155 160 Leu Leu Thr Ile Arg Leu Pro Tyr Cys Gly Pro Asn Val Ile Asp Ser 165 170 175 Tyr Phe Cys Asp Val Pro Pro Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Tyr Leu Thr Gly Val Leu Ile Val Ser Asn Ser Gly Thr Ile Ser Leu 195 200 205 Thr Cys Phe Leu Ala Leu Val Thr Ser Tyr Thr Ile Ile Leu Val Ser 210 215 220 Leu Arg Lys Gln Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys 225 230 235 240 Ser Ala His Phe Met Val Val Ala Phe Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Thr Arg Pro Asp Thr Ser Phe Ser Ile Asp Lys Val Val Ser 260 265 270 Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr 275 280 285 Leu Arg Asn Glu Glu Val Lys Ser Ala Ile Lys His Leu Arg Gln Lys 290 295 300 Gln Val Phe Ser

305 <210> 327 <211> 948 <212> DNA <213> Canis familiaris <400> 327

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atggaagcgg gggacctact caatcaaacc accttagtga cacacattcg gcttagaggc 60 ttatctgtag atcagagggt gcagatggct gtgtttgcca tgttcctcac tttctacgtc 120 ctgacactgg ctgggaacat cctcattgtc ataactatta tctacgaccg ccggcttcat 180 acccccatgt atttcttcct cagtaacctg tcttttatcg atgtgtgcca ctccactgtc 240 actgtcccca agatgctggt agacacatgg gcagaagaga agcttatctc ctttgacggc 300 tgcgtcactc agatgttttt cctgcacctc ttcgcctgca ccgagatctt tctgctcacc 360 gtcatggcct acgaccggta tgtggccatt tgcaagcccc tgcagtacct gacggtgatg 420 agctggagag tgtgtgtgct gctggctgta gccctgtggg tgggggggac aatccactcc 480 atatcgctga cctccctcac catcacgctg ccctactgtg gtcctgatga gattgacagc 540 ttcttctgcg atgtgcctca ggtgatcaaa ctggcctgca cggataccca catcattgaa 600 atcctcatcg tctccaacag cggcctgatc tccgtggtgt gtttcgtggt cctcgtggtg 660 tcctacgcgg tcatcctggt gagcctgcgg cagcagatct ccgaaggcag gcgcaaggcc 720 ttatccacct gtgcggccca cctcaccgtc gtcacactgt tcctgggaca ttgcatcttc 780 atctattccc gcccatccac cagcctcccg gaagacaagg tggtgtctgt gtttttcacg 840 gccgttaccc ccctgctgaa ccccatcatc tatactctta ggaatgaaga catgaagaat 900 gccttgaaca agttaatggg aaggttggag gggaaaggta aaaaatga 948

<210> 328 <211> 315 <212> PRT <213> Canis familiaris <400> 328

Met 1 Glu Ala Gly Asp Leu Leu Asn Gln Thr Thr Leu Val Thr His Ile 5 10 15 Arg Leu Arg Gly Leu Ser Val Asp Gln Arg Val Gln Met Ala Val Phe 20 25 30 Ala Met Phe Leu Thr Phe Tyr Val Leu Thr Leu Ala Gly Asn Ile Leu 35 40 45 Ile Val Ile Thr Ile Ile Tyr Asp Arg Arg Leu His Thr Pro Met Tyr

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50 55 60

Phe 65 Phe Leu Ser Asn Leu Ser Phe Ile Asp Val Cys His Ser Thr Val 70 75 80 Thr Val Pro Lys Met Leu Val Asp Thr Trp Ala Glu Glu Lys Leu Ile 85 90 95 Ser Phe Asp Gly Cys Val Thr Gln Met Phe Phe Leu His Leu Phe Ala 100 105 110 Cys Thr Glu Ile Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys Lys Pro Leu Gln Tyr Leu Thr Val Met Ser Trp Arg Val 130 135 140 Cys Val Leu Leu Ala Val Ala Leu Trp Val Gly Gly Thr Ile His Ser 145 150 155 160 Ile Ser Leu Thr Ser Leu Thr Ile Thr Leu Pro Tyr Cys Gly Pro Asp 165 170 175 Glu Ile Asp Ser Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala 180 185 190 Cys Thr Asp Thr His Ile Ile Glu Ile Leu Ile Val Ser Asn Ser Gly 195 200 205 Leu Ile Ser Val Val Cys Phe Val Val Leu Val Val Ser Tyr Ala Val 210 215 220 Ile Leu Val Ser Leu Arg Gln Gln Ile Ser Glu Gly Arg Arg Lys Ala 225 230 235 240 Leu Ser Thr Cys Ala Ala His Leu Thr Val Val Thr Leu Phe Leu Gly 245 250 255 His Cys Ile Phe Ile Tyr Ser Arg Pro Ser Thr Ser Leu Pro Glu Asp

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260

069269_0225_SL.TXT 265 270

Lys Val Val Ser Val Phe Phe Thr Ala Val Thr Pro Leu Leu Asn Pro 275 280 285

Ile Ile Tyr Thr Leu Arg Asn Glu Asp Met Lys Asn Ala Leu Asn Lys 290 295 300

Leu Met Gly Arg Leu Glu Gly Lys Gly Lys Lys 305 310 315 <210> 329 <211> 942 <212> DNA <213> Canis familiaris <400> 329 atgggagaaa atcagaccgt ggtcacagag tttattctac taggattttg tcttggccca 60 agaattcaga tggttctctt tgggctcttt accctgttct acaccctcac cctgctggga 120 aatgggctca tcctggggct catttcactg gacctcagac tgcacacccc catgtacttc 180 ttcctctccc acctggccat cgtcgacata gcctatgcct gcaacacagt gccccagatg 240 ctggtgaacc tcctgaggcc agacaagccc atctcctttg ctggctgcct gacgcagacc 300 tttcttttct tgagttttgc tcatactgaa tgtcttctcc tggtggtgat gtcctatgac 360 cggcatgtgg ccatctgcca ccccctccac tattgtgtca tcatgagctg gagagtctgc 420 atcaccctgg tggtggcttc ttgggcatgt ggcttcctgc tggctctggt ccatgtgagc 480 ctcatcctga ggctgccctt ctgtgggcct catgaaatca accacttctt ctgtgaaatc 540 ctgtctatcc tcaagctggc ctgtgctgac acccggctta accaagtggt catctttgtt 600 gcctgcatgt ttatcttagt ggtgcccctc tgtttggtgc tggtgtccta ctcgcgaatc 660 ctgttggcca tcctgaggat ccagtctggg gagggccgca gaaaggcctt ctccacctgc 720 tcctcccacc tctgtgtggt ggggctcttc tttggcagcg ccattgtcat gtacatggtc 780 cccaaatccc gccaccctga agaacagcag aagatccttt tcttatttta cagttttttc 840 aaccctatgc tgaaaccact gatctacagc ctgagaaatg cagaggtcaa gggtgccctg 900 aagagagtgc tatacaagga gagtcattcc caattggagt ga 942

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069269_0225_SL.TXT <210> 330 <211> 313 <212> PRT <213> Canis familiaris <400> 330

Met 1 Gly Glu Asn Gln 5 Thr Val Val Thr Glu Phe Ile Leu Leu Gly Phe 10 15 Cys Leu Gly Pro Arg Ile Gln Met Val Leu Phe Gly Leu Phe Thr Leu 20 25 30 Phe Tyr Thr Leu Thr Leu Leu Gly Asn Gly Leu Ile Leu Gly Leu Ile 35 40 45 Ser Leu Asp Leu Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Ile Val Asp Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met 65 70 75 80 Leu Val Asn Leu Leu Arg Pro Asp Lys Pro Ile Ser Phe Ala Gly Cys 85 90 95 Leu Thr Gln Thr Phe Leu Phe Leu Ser Phe Ala His Thr Glu Cys Leu 100 105 110 Leu Leu Val Val Met Ser Tyr Asp Arg His Val Ala Ile Cys His Pro 115 120 125 Leu His Tyr Cys Val Ile Met Ser Trp Arg Val Cys Ile Thr Leu Val 130 135 140 Val Ala Ser Trp Ala Cys Gly Phe Leu Leu Ala Leu Val His Val Ser 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro His Glu Ile Asn His Phe 165 170 175

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Phe Cys Glu Ile Leu Ser Ile Leu Lys Leu Ala Cys Ala Asp Thr Arg 190 180 185 Leu Asn Gln Val Val Ile Phe Val Ala Cys Met Phe Ile Leu Val Val 195 200 205 Pro Leu Cys Leu Val Leu Val Ser Tyr Ser Arg Ile Leu Leu Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val 245 250 255 Met Tyr Met Val Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Ile 260 265 270 Leu Phe Leu Phe Tyr Ser Phe Phe Asn Pro Met Leu Lys Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Ala Glu Val Lys Gly Ala Leu Lys Arg Val Leu 290 295 300 Tyr Lys Glu Ser His Ser Gln Leu Glu 305 310 <210> 331 <211> 933 <212> DNA <213> Canis familiaris <400> 331 atggcgggaa atcagacctc tgtcacagag ttcatcctat tgggctttcc cctcagccca gagattcaga tggttctctt tgggctcttc accctgttct acgccttcac cctgctgggg aatgggctca tcctggggct catctcactg gaccccagac tgcacacccc catgtacttc ttcctctccc acctggccat cgtcgacata gcctatgcct gcaacacggt gccccagatg ctggtgaacc tcctgaggcc agacaagccc atctcctttg ctggctgctt gacgcagacc

120

180

240

300

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tttcttttct tgacctttgc tcatactgag tgtcttctcc tggtggtgat gtcctatgac 360 cggtacgtgg ccatcagcca ccccctccac tattctgtca tcatgagctg gagagtctgc 420 atcaccctgg cattgactgc ctggatttta ggagtgctcc tggccctagt acatctaggg 480 ttactcatac cattgccttt ctgtggaccc cagaaagtca accacttttt ctgtgaaatt 540 atagctgtcc tcaaacttgc ctgtgcagat acccacgtta atgagattat ggtattgact 600 ggggccgtgt ctgtgctggt agggcctttt acctcaattg tgatatcata cattcatatt 660 ctacgtgcca tcctgaagat tcagtcaggg gaggggcgcc agaaagcctt ctccacctgc 720 tcatcccatc tctgtgtggt tggactcttt tatggcacag ccattataat gtatgttggg 780 cccagatatg ggaaccccaa ggagcaaaag aaatacctgc tcctgtttca cagccttttc 840 aatcccatgc tcaatcccct tatctatagt ctgaggaaca aagaagtcaa agctgctctg 900 aagaggattc ttgaaaaaga aagaacttca tga 933

<210> 332 <211> 310 <212> PRT <213> Canis familiaris <400> 332

Met Ala Gly Asn Gln Thr Ser Val Thr Glu Phe Ile Leu Leu Gly Phe 1 5 10 15 Pro Leu Ser Pro Glu Ile Gln Met Val Leu Phe Gly Leu Phe Thr Leu 20 25 30 Phe Tyr Ala Phe Thr Leu Leu Gly Asn Gly Leu Ile Leu Gly Leu Ile 35 40 45 Ser Leu Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Ile Val Asp Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met 65 70 75 80 Leu Val Asn Leu Leu Arg Pro Asp Lys Pro Ile Ser Phe Ala Gly Cys 85 90 95

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Leu Thr Gln Thr 100 Phe Leu Phe Leu Thr Phe Ala His Thr Glu Cys Leu 105 110 Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Ser His Pro 115 120 125 Leu His Tyr Ser Val Ile Met Ser Trp Arg Val Cys Ile Thr Leu Ala 130 135 140 Leu Thr Ala Trp Ile Leu Gly Val Leu Leu Ala Leu Val His Leu Gly 145 150 155 160 Leu Leu Ile Pro Leu Pro Phe Cys Gly Pro Gln Lys Val Asn His Phe 165 170 175 Phe Cys Glu Ile Ile Ala Val Leu Lys Leu Ala Cys Ala Asp Thr His 180 185 190 Val Asn Glu Ile Met Val Leu Thr Gly Ala Val Ser Val Leu Val Gly 195 200 205 Pro Phe Thr Ser Ile Val Ile Ser Tyr Ile His Ile Leu Arg Ala Ile 210 215 220 Leu Lys Ile Gln Ser Gly Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Tyr Gly Thr Ala Ile Ile 245 250 255 Met Tyr Val Gly Pro Arg Tyr Gly Asn Pro Lys Glu Gln Lys Lys Tyr 260 265 270 Leu Leu Leu Phe His Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Leu Lys Arg Ile Leu 290 295 300

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Glu Lys Glu Arg Thr Ser 305 310 <210> 333 <211> 933 <212> DNA <213> Canis familiaris <400> 333 atgacagaaa atcaaacatg ggtcccagaa ttcattctcc tgggattccc actcagccca 60 aagctgcggg tgttcctctt tgggctcttc accctgttct acgccttcac cctcctgggg 120 aacagcatca tcctggggct catctcactg gactcccgac tgcacacccc catgtacttt 180 ttcctctccc acctggccat cgttgatata gcctatgctt caaataatgt cccaaagatg 240 ctggcaaacc ttctaaacaa ggaaaaaact atctcctttg tcccatgcat aatgcagacc 300 tttttataca tggcttttgc tcacacggag tgtctcatct tagtaatgat gtcctatgac 360 cggtacgtgg caatctgcca tcccctacat tactctgtca tcatgagctg gagagtgtgc 420 actgttcagg ctgtcacttc ctgggcatgt ggctccctgc tggccctggt ccatgtgatt 480 ctcatcctga ggctgccctt ctgtgggcct catgaaatca accacttctt ctgtgaaatc 540 ctgtctgtcc tcaagctggc ctgtgctgac actaggctca accaagtggt catttttgct 600 gcttctgtgt ttatcttagt ggggcccctc tgcttggtgc tggtgtccta ctcgcgcatc 660 ctgtttgcca tcctgaggat ccagtctggg gaaggccgca gaaaggcctt ctccacctgc 720 tcctcccacc tctgtgtggt ggggctcttc tttggcagcg ccattgtcat gtacatggcc 780 cccaaatcca accaccctga ggagcagcag aagatccttt ctctgtttta tagccttttc 840 aaccctatgc tgaacccact gatctacagc ctgaggaaca cagaagtcaa gggtgccctg 900 aagagagtgc tatggaagga gagatcattg tga 933 <210> 334 <211> 310 <212> PRT <213> Canis familiaris <400> 334

Met Thr Glu Asn Gln Thr Trp Val Pro Glu Phe Ile Leu Leu Gly Phe 1 5 10 15

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Pro Leu Ser Pro Lys Leu Arg Val Phe Leu Phe Gly Leu Phe Thr Leu 20 25 30 Phe Tyr Ala Phe Thr Leu Leu Gly Asn Ser Ile Ile Leu Gly Leu Ile 35 40 45 Ser Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Ile Val Asp Ile Ala Tyr Ala Ser Asn Asn Val Pro Lys Met 65 70 75 80 Leu Ala Asn Leu Leu Asn Lys Glu Lys Thr Ile Ser Phe Val Pro Cys 85 90 95 Ile Met Gln Thr Phe Leu Tyr Met Ala Phe Ala His Thr Glu Cys Leu 100 105 110 Ile Leu Val Met Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu His Tyr Ser Val Ile Met Ser Trp Arg Val Cys Thr Val Gln Ala 130 135 140 Val Thr Ser Trp Ala Cys Gly Ser Leu Leu Ala Leu Val His Val Ile 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro His Glu Ile Asn His Phe 165 170 175 Phe Cys Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Arg 180 185 190 Leu Asn Gln Val Val Ile Phe Ala Ala Ser Val Phe Ile Leu Val Gly 195 200 205 Pro Leu Cys Leu Val Leu Val Ser Tyr Ser Arg Ile Leu Phe Ala Ile 210 215 220

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Leu Arg 225 Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val 245 250 255 Met Tyr Met Ala Pro Lys Ser Asn His Pro Glu Glu Gln Gln Lys Ile 260 265 270 Leu Ser Leu Phe Tyr Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Thr Glu Val Lys Gly Ala Leu Lys Arg Val Leu 290 295 300 Trp Lys Glu Arg Ser Leu

305 310 <210> 335 <211> 927 <212> DNA <213> Canis familiaris <400> 335

atggaagtgg agaaccagac ccaggtcacc aagttcattc tggtggggtt tcctgggaac 60 tggggcatgc gggtagcagt gttcctgatg ttcctcatgg cctatattgt gacagtggct 120 gaaaatgtgg tcatcatcct gctggtgcag caaaaccggc cactgcacaa gcctatgtac 180 ttcttcctgg ccaacctgtc tttcttggag acctggtaca tctctgtgac tgtgcctaaa 240 ttactattta gtttttggtc tgtgaacaac agtatctcct tcactcactg tatgatacaa 300 ctttacttct tcattgccct catgtgcaca gaatgtgtgc tcctggctgc catggccttt 360 gatcgttatg tagccatctg ccgtccactc cactacccca ccattatgag ccatgggctt 420 tgcttccgct tggctcttgg ttcctgggcc attggctttg gcatctcctt agctaagatt 480 tactttatct ctcgcctcag tttctgtggc cccaatgtca tcaatcactt cttctgtgac 540 atctctccag tacttaacct ctcctgcaca gacatgtctg tagctgagct ggtagacttt 600

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gtcctggcat tggtcatctt tctcttcccc ctctctatca ctgttctgtc ctatggatgc 660 atcctggcca ctgttctacg catgcctacc ggaaagcaga aagcgttctc tacttgtgcc 720 tcccaccttg tggtggtcac catcttctat tcagccacga ttttcatgta tgccaggccc 780 cgagccatcc atgccttcaa catgaacaaa gtgatttcca tcttctatgc tattgtcacc 840 cctgcactca accctttcat ttattgccta aggaacagag aggtcaaaga ggctctgaag 900 aaactggcct attgccaagc tatctga 927

<210> 336 <211> 308 <212> PRT <213> Canis familiaris <400> 336

Met 1 Glu Val Glu Asn 5 Gln Thr Gln Val Thr Lys Phe Ile Leu Val Gly 10 15 Phe Pro Gly Asn Trp Gly Met Arg Val Ala Val Phe Leu Met Phe Leu 20 25 30 Met Ala Tyr Ile Val Thr Val Ala Glu Asn Val Val Ile Ile Leu Leu 35 40 45 Val Gln Gln Asn Arg Pro Leu His Lys Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Leu Glu Thr Trp Tyr Ile Ser Val Thr Val Pro Lys 65 70 75 80 Leu Leu Phe Ser Phe Trp Ser Val Asn Asn Ser Ile Ser Phe Thr His 85 90 95 Cys Met Ile Gln Leu Tyr Phe Phe Ile Ala Leu Met Cys Thr Glu Cys 100 105 110 Val Leu Leu Ala Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Pro Thr Ile Met Ser His Gly Leu Cys Phe Arg Leu

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130 135 140

Ala Leu Gly Ser 145 Trp Ala Ile Gly Phe Gly Ile Ser Leu Ala Lys Ile 150 155 160 Tyr Phe Ile Ser Arg Leu Ser Phe Cys Gly Pro Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Val Leu Asn Leu Ser Cys Thr Asp Met 180 185 190 Ser Val Ala Glu Leu Val Asp Phe Val Leu Ala Leu Val Ile Phe Leu 195 200 205 Phe Pro Leu Ser Ile Thr Val Leu Ser Tyr Gly Cys Ile Leu Ala Thr 210 215 220 Val Leu Arg Met Pro Thr Gly Lys Gln Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Val Val Val Thr Ile Phe Tyr Ser Ala Thr Ile Phe Met 245 250 255 Tyr Ala Arg Pro Arg Ala Ile His Ala Phe Asn Met Asn Lys Val Ile 260 265 270 Ser Ile Phe Tyr Ala Ile Val Thr Pro Ala Leu Asn Pro Phe Ile Tyr 275 280 285 Cys Leu Arg Asn Arg Glu Val Lys Glu Ala Leu Lys Lys Leu Ala Tyr

290 295 300

Cys Gln Ala Ile 305 <210> 337 <211> 942 <212> DNA <213> Canis familiaris

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069269_0225_SL.TXT <400> 337 atgggccagg aaaataaaac ccagacatgg gtgagtgagt tcgttctgct gggattgtcc 60 agtgactggg aaactcaagt cttcctcttt ctcctggtcc tgaccatgta cttggtgact 120 cttgtgggaa atgtcctcat tcttcttctg atcagactgg acagcaggct tcataacccc 180 atgtacttct tccttagtgt tttatccttt gtggaccttt gttatgcaaa tagtattgcc 240 ccacaaatgc tggcccacct gctctcagcc cagaagtcca tcccattcta taactgtgtg 300 ctccaactct atacctcctt ggcattgggt gggtctgagt tcttcctgct gggagccatg 360 gcctatgacc gctatgtggc agtgtgccat ccactgcact acacagtcat catgcatgga 420 gagctgtgcc tggggttggc tgccggctgc ttggtggctg gtttcacaaa ttcgctgatg 480 gaaacaatca ttacattccg gcttcccttg tgtcacaatg ttattaatca ctttgcctgt 540 gagaccctag cagtgctacg gctagcttgt gtggacgtct ccttcaacaa ggtcatggtg 600 gccacctcag gatttttggt gatcatgctt ccctgttccc tggttctgtt ctcctatggt 660 cgtatagtta ttaccattct gcatatccat tctactcagg gacgtagcaa agcctttggg 720 acttgtgcct cccacctcac tgtggtttgc atgtgctttg gggctaccat cttcacctac 780 ttgggtccac ggtcagcctc ttcagtggaa gaggagaaga tggttgctct attctatgct 840 gtggtggcgc ctatgttgaa ccccttgatc tatagcttga ggaataagga agttatggct 900 gctcttcaaa aggttctcaa gaaattcaga gataaagagt aa 942 <210> 338 <211> 313 <212> PRT <213> Canis familiaris <400> 338

Met 1 Gly Gln Glu Asn Lys Thr Gln Thr Trp Val Ser Glu Phe Val Leu 5 10 15 Leu Gly Leu Ser Ser Asp Trp Glu Thr Gln Val Phe Leu Phe Leu Leu 20 25 30 Val Leu Thr Met Tyr Leu Val Thr Leu Val Gly Asn Val Leu Ile Leu 35 40 45

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Leu Leu 50 Ile Arg Leu Asp Ser 55 069269_0225_SL.TXT Arg Leu His Asn Pro Met 60 Tyr Phe Phe Leu Ser Val Leu Ser Phe Val Asp Leu Cys Tyr Ala Asn Ser Ile Ala 65 70 75 80 Pro Gln Met Leu Ala His Leu Leu Ser Ala Gln Lys Ser Ile Pro Phe 85 90 95 Tyr Asn Cys Val Leu Gln Leu Tyr Thr Ser Leu Ala Leu Gly Gly Ser 100 105 110 Glu Phe Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Tyr Val Ala Val 115 120 125 Cys His Pro Leu His Tyr Thr Val Ile Met His Gly Glu Leu Cys Leu 130 135 140 Gly Leu Ala Ala Gly Cys Leu Val Ala Gly Phe Thr Asn Ser Leu Met 145 150 155 160 Glu Thr Ile Ile Thr Phe Arg Leu Pro Leu Cys His Asn Val Ile Asn 165 170 175 His Phe Ala Cys Glu Thr Leu Ala Val Leu Arg Leu Ala Cys Val Asp 180 185 190 Val Ser Phe Asn Lys Val Met Val Ala Thr Ser Gly Phe Leu Val Ile 195 200 205 Met Leu Pro Cys Ser Leu Val Leu Phe Ser Tyr Gly Arg Ile Val Ile 210 215 220 Thr Ile Leu His Ile His Ser Thr Gln Gly Arg Ser Lys Ala Phe Gly 225 230 235 240 Thr Cys Ala Ser His Leu Thr Val Val Cys Met Cys Phe Gly Ala Thr 245 250 255

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Ile Phe Thr Tyr Leu Gly Pro Arg Ser Ala 265 Ser Ser Val Glu 270 Glu Glu 260 Lys Met Val Ala Leu Phe Tyr Ala Val Val Ala Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Met Ala Ala Leu Gln Lys 290 295 300 Val Leu Lys Lys Phe Arg Asp Lys Glu 305 310

<210> 339 <211> 936 <212> DNA <213> Canis familiaris <400> 339 atgggcaggg aaaaccagac atggatgagt gagttcattc tgctggggct gtccagctgc tgggacaccc aggtgtcctt atttgtcctt ttcctgatca tgtatctggt gaccgtgctg gggaacttcc tcatcatcct cctcatcaga ctggacagta ggctgcacac acccatgtac tttttcctca gtgtcttgtc attggtggac atctgttaca ccaacagcac tgtcccacag atgcttgttc acttcctgtc agcctggaag tccattccat tccacagctg tgtgctccag ctgtttatct ccctggcgat gggcagctca gagttcttcc tgctgggagc catggcctat gaccgctacg tggcagtgtg tcatccgttg cactacacag tcatcatgca tggagagctg tgcctgggct tggctgccgg ctgcttgggg gctggtttca ttaattcaat gatgcaggca atcatcatct ttcggctacc tttgtgccat aatgttatca atcactttgc ctgtgagatg ttggctgtac tgaggctgac ctgtgtggac gtctcgttca acaaggtcat ggtggccatc tcagggtctc tggtgatcat gcttccctgt ttcctggtcc tgttctccta tgttcgtata gttgctgcca ttctgcatat tcactctgcc caaggacgct gcagagcatt tgagacctgt gcttcccacc tcactgtggt ttccatgtgc tttggaacag ccatcttcac atacttgcga ccttctgctg gctcctcggc agagcaagag aagatggtcg ctctgttcta tgctgtggtg accccaatgc taaatccctt aatctacagc ttgaggaaca aggaggtaat gagtgcccta

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069269_0225_SL.TXT aggagactgt tgggaaaatg tagtgaaaaa aggtaa <210> 340 <211> 311 <212> PRT <213> Canis familiaris <400> 340

Met 1 Gly Arg Glu Asn 5 Gln Thr Trp Met Ser Glu Phe Ile Leu Leu Gly 10 15 Leu Ser Ser Cys Trp Asp Thr Gln Val Ser Leu Phe Val Leu Phe Leu 20 25 30 Ile Met Tyr Leu Val Thr Val Leu Gly Asn Phe Leu Ile Ile Leu Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Val Leu Ser Leu Val Asp Ile Cys Tyr Thr Asn Ser Thr Val Pro Gln 65 70 75 80 Met Leu Val His Phe Leu Ser Ala Trp Lys Ser Ile Pro Phe His Ser 85 90 95 Cys Val Leu Gln Leu Phe Ile Ser Leu Ala Met Gly Ser Ser Glu Phe 100 105 110 Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Tyr Val Ala Val Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met His Gly Glu Leu Cys Leu Gly Leu 130 135 140 Ala Ala Gly Cys Leu Gly Ala Gly Phe Ile Asn Ser Met Met Gln Ala 145 150 155 160 Ile Ile Ile Phe Arg Leu Pro Leu Cys His Asn Val Ile Asn His Phe 165 170 175

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Ala Cys Glu Met Leu Ala Val Leu Arg Leu Thr Cys Val Asp Val Ser 180 185 190 Phe Asn Lys Val Met Val Ala Ile Ser Gly Ser Leu Val Ile Met Leu 195 200 205 Pro Cys Phe Leu Val Leu Phe Ser Tyr Val Arg Ile Val Ala Ala Ile 210 215 220 Leu His Ile His Ser Ala Gln Gly Arg Cys Arg Ala Phe Glu Thr Cys 225 230 235 240 Ala Ser His Leu Thr Val Val Ser Met Cys Phe Gly Thr Ala Ile Phe 245 250 255 Thr Tyr Leu Arg Pro Ser Ala Gly Ser Ser Ala Glu Gln Glu Lys Met 260 265 270 Val Ala Leu Phe Tyr Ala Val Val Thr Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Met Ser Ala Leu Arg Arg Leu Leu 290 295 300 Gly Lys Cys Ser Glu Lys Arg 305 310

<210> 341 <211> 954 <212> DNA <213> Canis familiaris <400> 341 atgggaacaa ataaccagac atggatgaga gaatttattc tccttggctt gtccagtgac tgggacacac aggtctccct ctttgtcctg ctcttagtca tgtacttggt gacagtgctg ggaaacttcc tcatcgttct tctcatcaga ctggacagcc gactccacac tcccatgtat ttctttctca ccaacctctc cttcgttgac gtctcttatg ccacaagcat cgttcctcag atgttggcac atcttcttgc agcccataaa gcaatgccat ttgtgagctg tgccgcccag Page 383

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069269_0225_SL.TXT

ttattcttct ccctgggctt gggtgggatt gagtttgttc tactggcagt gatggcctat 360 gaccgctatg tggctgtgtg tgaccccctg cgatactcgg tcatcatgca cggagggctc 420 tgtactaggt tggccatcac ctcctgggtc agtggctcta tgaactctct catccatact 480 gccatcacat ttcagctgcc catgtgcaca aacaagtaca ttgatcacat atcatgtgaa 540 attttggctg tggtcagact ggcttgtgtg gatacttcct ccaacgagat tgcaatcacg 600 gtttcgagca ttgttctgct gatgacacct ttctgcctgg ttctcctgtc ctacatccag 660 atcatctcca ccatcctaaa gatccagtcc acagagggaa gaaagaaagc cttccacacc 720 tgtgcctctc acctcacagt ggttgtcctg tgctatggta tggcgatttt cacttacatc 780 cagccccgct ccagcccctc tgtccttcag gagaagttga tctctctctt ctatgctgtt 840 ttgacaccca tgctgaaccc catgatttat agtgtaagga ataaggaggt gaagggagcc 900 tggcagaaac tattagggca gttatctgga ataacgtcaa aactggcaac ttga 954

<210> 342 <211> 317 <212> PRT <213> Canis familiaris <400> 342

Met Gly Thr Asn Asn Gln Thr Trp Met Arg Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Ser Asp Trp Asp Thr Gln Val Ser Leu Phe Val Leu Leu Leu 20 25 30 Val Met Tyr Leu Val Thr Val Leu Gly Asn Phe Leu Ile Val Leu Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Phe Val Asp Val Ser Tyr Ala Thr Ser Ile Val Pro Gln 65 70 75 80

Met Leu Ala His Leu 85

Leu Ala Ala

His

Lys Ala Met 90

Pro Phe Val Ser 95

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Cys Ala Ala Gln 100 Leu Phe Phe Ser Leu Gly Leu Gly Gly Ile Glu Phe 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asp 115 120 125 Pro Leu Arg Tyr Ser Val Ile Met His Gly Gly Leu Cys Thr Arg Leu 130 135 140 Ala Ile Thr Ser Trp Val Ser Gly Ser Met Asn Ser Leu Ile His Thr 145 150 155 160 Ala Ile Thr Phe Gln Leu Pro Met Cys Thr Asn Lys Tyr Ile Asp His 165 170 175 Ile Ser Cys Glu Ile Leu Ala Val Val Arg Leu Ala Cys Val Asp Thr 180 185 190 Ser Ser Asn Glu Ile Ala Ile Thr Val Ser Ser Ile Val Leu Leu Met 195 200 205 Thr Pro Phe Cys Leu Val Leu Leu Ser Tyr Ile Gln Ile Ile Ser Thr 210 215 220 Ile Leu Lys Ile Gln Ser Thr Glu Gly Arg Lys Lys Ala Phe His Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Val Leu Cys Tyr Gly Met Ala Ile 245 250 255 Phe Thr Tyr Ile Gln Pro Arg Ser Ser Pro Ser Val Leu Gln Glu Lys 260 265 270 Leu Ile Ser Leu Phe Tyr Ala Val Leu Thr Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Val Arg Asn Lys Glu Val Lys Gly Ala Trp Gln Lys Leu 290 295 300

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Leu Gly Gln Leu Ser Gly Ile Thr Ser Lys Leu Ala Thr 305 310 315 <210> 343 <211> 954 <212> DNA <213> Canis familiaris <400> 343 atgggaacag gtaaccagac ttgggtgaga gagtttgttc tccttggcct gtccagtgac 60 tgggacacag aggtgtccct ctttgtcctg ttcttgatca catacatggt gacagtgctg 120 ggaaacttcc tcatcattct tctcatcaga ctggacagcc gactccacac tcccatgtat 180 ttctttctca ccaacctctc cctcgttgac gtctcttatg ccacaagcat cattcctcag 240 atgttggcac atcttcttgc agcccataaa gcaatcccat ttgtgagctg tgccgcccag 300 ttattcttct ccttgggctt gggtgggatt gagtttgttc tactggcagt gatggcctat 360 gaccgctatg tggccgtgtg tgaccccctg cgatactcgg tcatcatgca cggagggctc 420 tgtactaggt tggccatcac ctcctgggtc agtggctcta tgaactctct catgcagact 480 gtcatcacat ttcagctgcc catgtgcaca aacaagtaca ttgatcacat atcctgcgaa 540 cttctagctg tggtcagact ggcttgtgtg gatacttcct ccaacgagat tgcaatcatg 600 gtttctagca ttgttctgct gatgacacct ttctgcctgg ttctcctgtc ctacatccag 660 attatctcca ccatcctaaa gatccagtcc acagagggaa gaaagaaagc cttccacacc 720 tgtgcctctc acctcacagt ggttgtcctg tgctatggta tggcgatttt cacttacatc 780 cagccccgct ccagcccctc tgtccttcag gagaagttga tctctctctt ctattctgtt 840 ttgacaccaa tgctgaaccc catgatttat agtgtaagga ataaggaggt gaagggagcc 900 tggcagaaac tattagggca attaactgga ataacttcaa aactagcaac ttga 954 <210> 344 <211> 317 <212> PRT <213> Canis familiaris <400> 344

Met Gly Thr Gly Asn Gln Thr Trp Val Arg Glu Phe Val Leu Leu Gly Page 386

0 6926 9_02 25_S L.TX T 1 5 10 15 Leu Ser Ser Asp Trp Asp Thr Glu Val Ser Leu Phe Val Leu Phe Leu 20 25 30 Ile Thr Tyr Met Val Thr Val Leu Gly Asn Phe Leu Ile Ile Leu Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Leu Val Asp Val Ser Tyr Ala Thr Ser Ile Ile Pro Gln 65 70 75 80 Met Leu Ala His Leu Leu Ala Ala His Lys Ala Ile Pro Phe Val Ser 85 90 95 Cys Ala Ala Gln Leu Phe Phe Ser Leu Gly Leu Gly Gly Ile Glu Phe 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asp 115 120 125 Pro Leu Arg Tyr Ser Val Ile Met His Gly Gly Leu Cys Thr Arg Leu 130 135 140 Ala Ile Thr Ser Trp Val Ser Gly Ser Met Asn Ser Leu Met Gln Thr 145 150 155 160 Val Ile Thr Phe Gln Leu Pro Met Cys Thr Asn Lys Tyr Ile Asp His 165 170 175 Ile Ser Cys Glu Leu Leu Ala Val Val Arg Leu Ala Cys Val Asp Thr 180 185 190 Ser Ser Asn Glu Ile Ala Ile Met Val Ser Ser Ile Val Leu Leu Met 195 200 205 Thr Pro Phe Cys Leu Val Leu Leu Ser Tyr Ile Gln Ile Ile Ser Thr

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210 215 220 Ile Leu Lys Ile Gln Ser Thr Glu Gly Arg Lys Lys Ala Phe His Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Val Leu Cys Tyr Gly Met Ala Ile 245 250 255 Phe Thr Tyr Ile Gln Pro Arg Ser Ser Pro Ser Val Leu Gln Glu Lys 260 265 270 Leu Ile Ser Leu Phe Tyr Ser Val Leu Thr Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Val Arg Asn Lys Glu Val Lys Gly Ala Trp Gln Lys Leu 290 295 300 Leu Gly Gln Leu Thr Gly Ile Thr Ser Lys Leu Ala Thr

305 310 315 <210> 345 <211> 954 <212> DNA <213> Canis familiaris <400> 345

atggacacag aaaaccagac ttgggtgaga gagtttattc tccttggctt gtccagtgac 60 tgggacacac aggtctccct ctttgtcctc ttcttgatca tgtacatggt gacagtgctg 120 ggaaacttcc tcatcattct tctcatcaga ctggacagcc gactccacac tcccatgtat 180 ttctttctca ccaacctctc cttcgttgac gtctcttatg ccacaagcat tgttcctcag 240 atgttggcac atcttcttgc agcccataaa gcaatcccat ttgtgagctg tgccgcccag 300 ttattcttct ccctgggctt gggtgggatt gagtttgttc tactggcagt gatggcctat 360 gaccgctatg tggccgtgtg tgaccccctg cgatactcgg tcatcatgca cggagggctc 420 tgtactaggt tggccatcac ctcctgggtc agtggctcta tgaactctct catgcagact 480 gtcatcacat ttcagctgcc catgtgcaca aataagtaca ttgatcacat atcatgtgaa 540 atcctagctg taatcaggct ggcctgtgta gacatctcct ccaacgagat tgcaatcatg 600

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gtttctagca ttgttctgct gatgacacct ttcttcctgg ttctcctgtc ctacatccag 660 atcatctcca ccatcctaaa gatccagtcc acagagggaa gaaagaaagc cttccacacc 720 tgtgcctctc acctcacagt ggttgtcctg tgctatggca tgaccatctt cacttacatc 780 cagccccgct ccagcccctc tgtccttcag gagaagttga tttctctctt ctatgccatt 840 ttgatgcctg tgctgaaccc catgatttat agtgtaagga ataaggaggt gaagggagcc 900 tggcagaaac tattagggca attatctgga ataacgtcaa aactggcaac ttga 954

<210> 346 <211> 317 <212> PRT <213> Canis familiaris <400> 346

Met Asp Thr Glu Asn Gln Thr Trp Val Arg Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Ser Asp Trp Asp Thr Gln Val Ser Leu Phe Val Leu Phe Leu 20 25 30 Ile Met Tyr Met Val Thr Val Leu Gly Asn Phe Leu Ile Ile Leu Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Phe Val Asp Val Ser Tyr Ala Thr Ser Ile Val Pro Gln 65 70 75 80 Met Leu Ala His Leu Leu Ala Ala His Lys Ala Ile Pro Phe Val Ser 85 90 95 Cys Ala Ala Gln Leu Phe Phe Ser Leu Gly Leu Gly Gly Ile Glu Phe 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asp 115 120 125

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Pro Leu 130 Arg Tyr Ser Val Ile 135 069269_0225_SL.TXT Met His Gly Gly Leu Cys 140 Thr Arg Leu Ala Ile Thr Ser Trp Val Ser Gly Ser Met Asn Ser Leu Met Gln Thr 145 150 155 160 Val Ile Thr Phe Gln Leu Pro Met Cys Thr Asn Lys Tyr Ile Asp His 165 170 175 Ile Ser Cys Glu Ile Leu Ala Val Ile Arg Leu Ala Cys Val Asp Ile 180 185 190 Ser Ser Asn Glu Ile Ala Ile Met Val Ser Ser Ile Val Leu Leu Met 195 200 205 Thr Pro Phe Phe Leu Val Leu Leu Ser Tyr Ile Gln Ile Ile Ser Thr 210 215 220 Ile Leu Lys Ile Gln Ser Thr Glu Gly Arg Lys Lys Ala Phe His Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Val Leu Cys Tyr Gly Met Thr Ile 245 250 255 Phe Thr Tyr Ile Gln Pro Arg Ser Ser Pro Ser Val Leu Gln Glu Lys 260 265 270 Leu Ile Ser Leu Phe Tyr Ala Ile Leu Met Pro Val Leu Asn Pro Met 275 280 285 Ile Tyr Ser Val Arg Asn Lys Glu Val Lys Gly Ala Trp Gln Lys Leu 290 295 300 Leu Gly Gln Leu Ser Gly Ile Thr Ser Lys Leu Ala Thr 305 310 315

<210> 347 <211> 468 <212> DNA <213> Canis familiaris

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069269_0225_SL.TXT <400> 347

ctcagcatgt ccagtgacac aggggtctcc ctctttgttc tcgtcttgat tacatacatg 60 gtaacaatgc tgggaaaatt cctcatcact cttctcatca gactggacag ctgactccac 120 actcccatgt atttctttcc tgccaatatc tttgtcattg atgtctctta tgccacaagc 180 atcattcctc agatgctggt gaatcttctt gcagcccata aagcaatctc atttgtgagc 240 tgtgccgctc agttattttt ctccctgggt ttgggtgggt ttgaggttct agtggcagtg 300 atggcctata acaggtctgt ggctatatgt gaaccactgc aatactcagt catcatgcat 360 ggaagtctct gtattagatt ggccattata tcctgggtca atgtctcctt gagcatgttc 420 atgcaagagc tcaaaaataa aataattatg tgcaatccta accatgta 468

<210> 348 <211> 114 <212> PRT <213> Canis familiaris <400> 348

Met Tyr Phe Phe Pro Ala Asn Ile Phe Val Ile Asp Val Ser Tyr Ala 1 5 10 15 Thr Ser Ile Ile Pro Gln Met Leu Val Asn Leu Leu Ala Ala His Lys 20 25 30 Ala Ile Ser Phe Val Ser Cys Ala Ala Gln Leu Phe Phe Ser Leu Gly 35 40 45 Leu Gly Gly Phe Glu Val Leu Val Ala Val Met Ala Tyr Asn Arg Ser 50 55 60 Val Ala Ile Cys Glu Pro Leu Gln Tyr Ser Val Ile Met His Gly Ser 65 70 75 80 Leu Cys Ile Arg Leu Ala Ile Ile Ser Trp Val Asn Val Ser Leu Ser 85 90 95 Met Phe Met Gln Glu Leu Lys Asn Lys Ile Ile Met Cys Asn Pro Asn 100 105 110

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His Val <210> 349 <211> 954 <212> DNA <213> Canis familiaris <400> 349 atggaaatag ataaccagac atgggcgaga gagtttattc tccttggcct gtccagtgac 60 tgggacacag aggtgtccct ctttgtactg ttcttgatca catacatggt gacagtgctg 120 ggaaacttcc tcatcattct tctcatcaga ctggacagcc gactccacac tcccatgtat 180 ttctttctca ccaacctctc cctcgttgac gtctcttatg ccacaagcat cgttcctcag 240 atgttggcac atcttcttgc agcccataaa gcaatcccgt ttgtgaaatg tgccgcccag 300 ttattcttct ccctgggctt gggtgggatt gagtttgttc tactggcagt gatggcctat 360 gaccgctatg tggctgtgtg tgaccccctg cgatactcgg tcatcatgca cggagggctc 420 tgtactaggt tggccatcac ctcctgggtc agtggctcta tgaactctct catgcagact 480 gccatcacat ttcagctgcc catgtgcaca aacaagtaca ttgatcacat atcctgcgaa 540 ctcctagctg tggtcagact ggcttgtgtg gatacttcct ccaacgagat tgcaatcatg 600 gtttctagca ttgttctgct gatgacacct ttctgcctgg ttctcctgtc ctacatccag 660 atcatctcca ccatcctaaa gatccagtcc acagagggaa gaaagaaagc cttccacacc 720 tgtgcctctc acctcacagt ggttgtcctg tgctatggca tgaccatctt cacttacatc 780 cagccccatt ctggcccctc tgtccttcag gagaagttaa tctctctctt ctatgccatt 840 ttaatgccca tgctgaaccc tatgatttat agtctaagga ataaggaggt gaagggagcc 900 tggcagaaac tattagggca gttatctggg ttaatatcaa aactggcaac ttga 954 <210> 350 <211> 317 <212> PRT <213> Canis familiaris <400> 350

Met Glu Ile Asp Asn Gln Thr Trp Ala Arg Glu Phe Ile Leu Leu Gly 1 5 10 15

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Leu Ser Ser Asp 20 Trp Asp Thr Glu Val Ser Leu Phe Val Leu Phe Leu 25 30 Ile Thr Tyr Met Val Thr Val Leu Gly Asn Phe Leu Ile Ile Leu Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Leu Val Asp Val Ser Tyr Ala Thr Ser Ile Val Pro Gln 65 70 75 80 Met Leu Ala His Leu Leu Ala Ala His Lys Ala Ile Pro Phe Val Lys 85 90 95 Cys Ala Ala Gln Leu Phe Phe Ser Leu Gly Leu Gly Gly Ile Glu Phe 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asp 115 120 125 Pro Leu Arg Tyr Ser Val Ile Met His Gly Gly Leu Cys Thr Arg Leu 130 135 140 Ala Ile Thr Ser Trp Val Ser Gly Ser Met Asn Ser Leu Met Gln Thr 145 150 155 160 Ala Ile Thr Phe Gln Leu Pro Met Cys Thr Asn Lys Tyr Ile Asp His 165 170 175 Ile Ser Cys Glu Leu Leu Ala Val Val Arg Leu Ala Cys Val Asp Thr 180 185 190 Ser Ser Asn Glu Ile Ala Ile Met Val Ser Ser Ile Val Leu Leu Met 195 200 205 Thr Pro Phe Cys Leu Val Leu Leu Ser Tyr Ile Gln Ile Ile Ser Thr 210 215 220

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Ile 225 Leu Lys Ile Gln Ser Thr Glu Gly Arg Lys Lys Ala Phe His Thr 240 230 235 Cys Ala Ser His Leu Thr Val Val Val Leu Cys Tyr Gly Met Thr Ile 245 250 255 Phe Thr Tyr Ile Gln Pro His Ser Gly Pro Ser Val Leu Gln Glu Lys 260 265 270 Leu Ile Ser Leu Phe Tyr Ala Ile Leu Met Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Trp Gln Lys Leu 290 295 300 Leu Gly Gln Leu Ser Gly Leu Ile Ser Lys Leu Ala Thr 305 310 315

<210> 351 <211> 942 <212> DNA <213> Canis familiaris <400> 351

atggagaaaa atcaaacaat ggttacagaa ttcatcctat tgggattttg tcttggtcca 60 agaattcaga tggttctctt tgggctcttc accctgttct acgccttcac cctgctgggg 120 aatgggctca tcctggggct catctcactg gaccccagac tgcacacccc catgtacttc 180 ttcctctccc acctggccat cgtcgacata gcctatgcct gcaacacggt gccccagatg 240 ctggtgaacc tcctgaggcc agacaagccc atctcctttg ctggctgcct gacgcagacc 300 tttctctttt tgacttttgc tctgatagaa tgtcttctcc tggtggtgat gtcctatgac 360 cggtatgtgg ccatttgcca ccccctccgc tattctgtga tcatgaactg gagagtctgt 420 atcaccctga tggtggcttc ctgggcatgt ggctccctgc tggccctggt ccatgtgagc 480 ctcatcctga ggctgccctt ctgtgggcct catgaaatca accacttctt ctgtgaaatc 540 ctgtctatcc tcaagctggc ctgtgctgac acccggctta accaagtggt catctttgtt 600

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gcctgcatgt ttatcttagt ggtgcccctc tgcttggtgc tggtgtccta ctcacgcatc 660 ctgttggcca tcctgaggat ccagtctggg gagggccgca gaaaggcctt ctctacctgt 720 tcctcccacc tctgtgtggt ggggctcttc tttggcagtg ccattgtcat gtacatggcc 780 cccaaatccc accaccctga agagcagcag aagatccttt tcttgtttta cagccttttc 840 aaccctatgc tgaacccact gatctacagc ctaagaaata cagaagtcaa gagtgccctg 900 agaagagcaa tgtgcaagaa aagtcattcc caattggagt ga 942

<210> 352 <211> 313 <212> PRT <213> Canis familiaris <400> 352

Met 1 Glu Lys Asn Gln Thr Met Val Thr Glu Phe Ile Leu Leu Gly Phe 5 10 15 Cys Leu Gly Pro Arg Ile Gln Met Val Leu Phe Gly Leu Phe Thr Leu 20 25 30 Phe Tyr Ala Phe Thr Leu Leu Gly Asn Gly Leu Ile Leu Gly Leu Ile 35 40 45 Ser Leu Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Ile Val Asp Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met 65 70 75 80 Leu Val Asn Leu Leu Arg Pro Asp Lys Pro Ile Ser Phe Ala Gly Cys 85 90 95 Leu Thr Gln Thr Phe Leu Phe Leu Thr Phe Ala Leu Ile Glu Cys Leu 100 105 110 Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu Arg Tyr Ser Val Ile Met Asn Trp Arg Val Cys Ile Thr Leu Met

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130 135 069269_0225_SL.TXT 140 Val Ala Ser Trp Ala Cys Gly Ser Leu Leu Ala Leu Val His Val Ser 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro His Glu Ile Asn His Phe 165 170 175 Phe Cys Glu Ile Leu Ser Ile Leu Lys Leu Ala Cys Ala Asp Thr Arg 180 185 190 Leu Asn Gln Val Val Ile Phe Val Ala Cys Met Phe Ile Leu Val Val 195 200 205 Pro Leu Cys Leu Val Leu Val Ser Tyr Ser Arg Ile Leu Leu Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val 245 250 255 Met Tyr Met Ala Pro Lys Ser His His Pro Glu Glu Gln Gln Lys Ile 260 265 270 Leu Phe Leu Phe Tyr Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Thr Glu Val Lys Ser Ala Leu Arg Arg Ala Met 290 295 300 Cys Lys Lys Ser His Ser Gln Leu Glu 305 310 <210> 353 <211> 966 <212> DNA <213> Canis familiaris

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069269_0225_SL.TXT <400> 353

atggacggtc ccggcaacgc cagcgtgccc cgaggctttc tccttcaggg cttctctgag 60 ttcccacacc tgaggcccgt gctcttcttg ctgctgctgg ccgtgcacct ggccaccgtg 120 ggcgggaacc tgctcatcct ggtggccgtg gcctcggtgc ccagccggcc gcccatgctg 180 ctcttcctgt gccagctgtc agccatcgag ctctgttaca cgctggtggt ggtgccccgc 240 tccctggccg acctggccgc gccggggccc cccgggggca gccccatctc cttcctgggc 300 tgcgcgctgc agatgcagat gttcgtggca ctgggtgggg ccgagtgctt cctgctggcc 360 accatggcct acgaccgcta cgtggccgtc tgccacccgc tgcgctacgc ggcggtggtc 420 accccggggc tgtgcgcgcg gctggccctg gcctgctgcc tcgggggcct ggcggtgtcc 480 gtggggctgg cgggggccgt cttccacctg cccttctgcg gctcccgcct gctggtgcac 540 ttcttctgcg acatcacggc gctgctggag ctggcctgca cgcggagcta cgcggacgag 600 ctgcccctgc tgggcgcctg cctgctgctg ctgctgctgc cctcgctgct catcctggcc 660 tcctacgggg ccatcgccgc cgccctgcac cgcctgcgct gcccccgcgg ccggcgcaag 720 gccgcctcca cctgcgcctc gcacctggcc gtcacctgcc tgcactacgg ctgcgccacc 780 ttcatgtacg cgcgccccaa ggccagctac tccccgcggc gggaccgcac gctggcgctg 840 gtctacacca acgtcacccc gctgctgtac ccgctcatct acagcctgcg caatcgcgag 900 gtcaccgcgg ccatccgcag ggtgctgggg cgggggcggc aggcgcaagg tctgcgtgag 960

ccctga 966 <210> 354 <211> 321 <212> PRT <213> Canis familiaris <400> 354

Met Asp Gly Pro Gly Asn Ala Ser Val Pro Arg Gly Phe Leu Leu Gln 1 5 10 15 Gly Phe Ser Glu Phe Pro His Leu Arg Pro Val Leu Phe Leu Leu Leu 20 25 30 Leu Ala Val His Leu Ala Thr Val Gly Gly Asn Leu Leu Ile Leu Val

35 40 45

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Ala Val 50 Ala Ser Val Pro Ser Arg 55 Pro Pro Met Leu 60 Leu Phe Leu Cys Gln Leu Ser Ala Ile Glu Leu Cys Tyr Thr Leu Val Val Val Pro Arg 65 70 75 80 Ser Leu Ala Asp Leu Ala Ala Pro Gly Pro Pro Gly Gly Ser Pro Ile 85 90 95 Ser Phe Leu Gly Cys Ala Leu Gln Met Gln Met Phe Val Ala Leu Gly 100 105 110 Gly Ala Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Val Cys His Pro Leu Arg Tyr Ala Ala Val Val Thr Pro Gly Leu 130 135 140 Cys Ala Arg Leu Ala Leu Ala Cys Cys Leu Gly Gly Leu Ala Val Ser 145 150 155 160 Val Gly Leu Ala Gly Ala Val Phe His Leu Pro Phe Cys Gly Ser Arg 165 170 175 Leu Leu Val His Phe Phe Cys Asp Ile Thr Ala Leu Leu Glu Leu Ala 180 185 190 Cys Thr Arg Ser Tyr Ala Asp Glu Leu Pro Leu Leu Gly Ala Cys Leu 195 200 205 Leu Leu Leu Leu Leu Pro Ser Leu Leu Ile Leu Ala Ser Tyr Gly Ala 210 215 220 Ile Ala Ala Ala Leu His Arg Leu Arg Cys Pro Arg Gly Arg Arg Lys 225 230 235 240 Ala Ala Ser Thr Cys Ala Ser His Leu Ala Val Thr Cys Leu His Tyr 245 250 255

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Gly Cys Ala Thr Phe Met Tyr Ala Arg 265 Pro Lys Ala Ser Tyr 270 Ser Pro 260 Arg Arg Asp Arg Thr Leu Ala Leu Val Tyr Thr Asn Val Thr Pro Leu 275 280 285 Leu Tyr Pro Leu Ile Tyr Ser Leu Arg Asn Arg Glu Val Thr Ala Ala 290 295 300 Ile Arg Arg Val Leu Gly Arg Gly Arg Gln Ala Gln Gly Leu Arg Glu 305 310 315 320

Pro <210> 355 <211> 942 <212> DNA <213> Canis familiaris <400> 355 atgaggaggg acaacctgac ctgggagagt gaatttgtcc tcttggggct ctccagcgac aggcagaccc aggttggatt ctttgtccta tttggggccg cctacctgct gactctgctg ggcaacgggc tcatcatcct cctgatcgga ctggatgcac gactgcacct gcccatgtac ttcttcctct gcaacctctc ggtggtggac atttgctaca cctctagcgg ggtcccccag atgctggtgc acttcctcct ggagaagaag accatctcct tcatccgatg tggggcccag ctcttcttct cactggccct agggggtacc gaattcctgc tgctggccgc tatggcctac gaccgctacg tggctgtctg tgaccccctg cgctatgtag cagtgatgag cccaaggtgc tgtgttgggc tggccgctgt ctcttggctc ataggcctgg tgaactctgt ggtggagacg gtggtcacca tgcgcctgcc cacctgtggg caccacgtgc tgaaccacgt ggcctgtgag actctggcat tggtccgcct ggcctgcgtg gacatcaccc tcaaccaggt gttcatcgtg gcctccagtg tggtggtgct gctgctgccc tgctgcctgg tctcactgtc ctatgcctac attgtggctg ccattctgcg gatccactcc accgggggac gtcgcaaagc cttcgggacc

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180

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069269_0225_SL.TXT tgtgcgtccc acctcacagt ggtctccatg tcttacggga tggccctggt tacctacatg cagccccact ccacggcctc tgcccagcag gacaaggtgg tggtgctctt ttatgccgtg gtgaccccca tgctgaatcc actcatctac agtctgcgca accaggagat gaaggctgct ctgagtcgag ttctgatgag gagttctgaa tcaaaacttt ag

780

840

900

942 <210> 356 <211> 313 <212> PRT <213> Canis familiaris <400> 356

Met Arg Arg Asp Asn Leu Thr Trp Glu Ser Glu Phe Val Leu Leu Gly 1 5 10 15 Leu Ser Ser Asp Arg Gln Thr Gln Val Gly Phe Phe Val Leu Phe Gly 20 25 30 Ala Ala Tyr Leu Leu Thr Leu Leu Gly Asn Gly Leu Ile Ile Leu Leu 35 40 45 Ile Gly Leu Asp Ala Arg Leu His Leu Pro Met Tyr Phe Phe Leu Cys 50 55 60 Asn Leu Ser Val Val Asp Ile Cys Tyr Thr Ser Ser Gly Val Pro Gln 65 70 75 80 Met Leu Val His Phe Leu Leu Glu Lys Lys Thr Ile Ser Phe Ile Arg 85 90 95 Cys Gly Ala Gln Leu Phe Phe Ser Leu Ala Leu Gly Gly Thr Glu Phe 100 105 110 Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asp 115 120 125 Pro Leu Arg Tyr Val Ala Val Met Ser Pro Arg Cys Cys Val Gly Leu 130 135 140 Ala Ala Val Ser Trp Leu Ile Gly Leu Val Asn Ser Val Val Glu Thr

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145 150 155 160 Val Val Thr Met Arg Leu Pro Thr Cys Gly His His Val Leu Asn His 165 170 175 Val Ala Cys Glu Thr Leu Ala Leu Val Arg Leu Ala Cys Val Asp Ile 180 185 190 Thr Leu Asn Gln Val Phe Ile Val Ala Ser Ser Val Val Val Leu Leu 195 200 205 Leu Pro Cys Cys Leu Val Ser Leu Ser Tyr Ala Tyr Ile Val Ala Ala 210 215 220 Ile Leu Arg Ile His Ser Thr Gly Gly Arg Arg Lys Ala Phe Gly Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ser Met Ser Tyr Gly Met Ala Leu 245 250 255 Val Thr Tyr Met Gln Pro His Ser Thr Ala Ser Ala Gln Gln Asp Lys 260 265 270 Val Val Val Leu Phe Tyr Ala Val Val Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Met Lys Ala Ala Leu Ser Arg Val 290 295 300 Leu Met Arg Ser Ser Glu Ser Lys Leu 305 310

<210> 357 <211> 429 <212> DNA <213> Canis familiaris <400> 357 ggggctctcc atgacaggca ggcccaggct ggattctttg tcctatttgg agccgcctac ctgctgatcc tgctgggcaa cgggctcatc atcctcctga ccggactgga tgcacgactg Page 401

120

069269_0225_SL.TXT cacctgccca tgtacttttt cctctgcaac ctcttggtgt tggatgtctg atacacttct 180 gttcctcaga tgctggcaca ctttctcctg gagaagaaga ccatcttctt catctgatgt 240 gggatccagc tcttcttctc actggccctg agggatacca agatcctgct actggctcct 300 atggcctgtg actgctacat gactgcctgt gaccccctgc attatgtgac agcagtctct 360 tggcttataa gcctagtgaa ttttgtggtg tagacactgg tcatcatgca cctgcccacc 420 tgtgggcac 429 <210> 358 <211> 56 <212> PRT <213> Canis familiaris <400> 358

Gly 1 Ala Leu His Asp Arg Gln Ala Gln Ala Gly Phe Phe Val Leu Phe 5 10 15 Gly Ala Ala Tyr Leu Leu Ile Leu Leu Gly Asn Gly Leu Ile Ile Leu 20 25 30 Leu Thr Gly Leu Asp Ala Arg Leu His Leu Pro Met Tyr Phe Phe Leu 35 40 45 Cys Asn Leu Leu Val Leu Asp Val

50 55 <210> 359 <211> 948 <212> DNA <213> Canis familiaris <400> 359 atgagtaact tcagtatcgt cagggaattt gtgctgctgg gattttcaca tctccatgag 60 ttccagatcc tcctctttgc attcatccta ttgatatatg tgctgactgt gctggggaac 120 ctggccatta tcaccctcac atgccttgac acccgcctcc actcacccat gtacttcttc 180 ctctgcaact tctccctcat ggagatgctg gtcacctcca ctgtggttcc taggatgctg 240 gcagacctac tatctactca taagaccatt tccctggcca agtgcctgac ccagtctttc 300

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ttttacttct ctttgggttc caccaacttc ttgattctca cagtcatggc ctttgatcgc 360 tacgtggcta tctgccgccc tctgcactac ccaaccatca tgaatggtcc agtgtgtgtg 420 aagctggtgg cagtctgctg ggtggttggc tttgtctcca tcatctcccc caccctgcag 480 aaaacacaac tctggttctg cggccctaat atcatcgacc attacttttg tgactctgcc 540 ccacttctca agctttcctg ctctgatacc caccacattg agcgcatgga tttcttctta 600 tcttttctct ttgtgctggc caccatgatg ctgatcatag tgtcctattt cctcattgtg 660 gctgcagtgc tgcgaattcc ctccttctct gggcgccaga aggccttctc cacctgtgcc 720 tcccacctca ctgtggtggt tctgggctat ggcagcacca tcttcatcta tgtgaggcca 780 ggcaagggcc actccacaca cctcaacaag gtggtagctc tgatgactgc agtggtgacc 840 cctttcctca atcccttcat cttcaccttc cggaatgaga agttcaagga ggtcattgaa 900 gatatgacca aaagactccg cttcagagat gcagcagctc acagatga 948

<210> 360 <211> 315 <212> PRT <213> Canis familiaris <400> 360

Met Ser 1 Asn Phe Ser 5 Ile Val Arg Glu Phe Val Leu Leu Gly Phe Ser 10 15 His Leu His Glu Phe Gln Ile Leu Leu Phe Ala Phe Ile Leu Leu Ile 20 25 30 Tyr Val Leu Thr Val Leu Gly Asn Leu Ala Ile Ile Thr Leu Thr Cys 35 40 45 Leu Asp Thr Arg Leu His Ser Pro Met Tyr Phe Phe Leu Cys Asn Phe 50 55 60 Ser Leu Met Glu Met Leu Val Thr Ser Thr Val Val Pro Arg Met Leu 65 70 75 80 Ala Asp Leu Leu Ser Thr His Lys Thr Ile Ser Leu Ala Lys Cys Leu 85 90 95

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Thr Gln Ser Phe 100 Phe Tyr Phe Ser Leu Gly Ser Thr Asn Phe Leu Ile 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125 His Tyr Pro Thr Ile Met Asn Gly Pro Val Cys Val Lys Leu Val Ala 130 135 140 Val Cys Trp Val Val Gly Phe Val Ser Ile Ile Ser Pro Thr Leu Gln 145 150 155 160 Lys Thr Gln Leu Trp Phe Cys Gly Pro Asn Ile Ile Asp His Tyr Phe 165 170 175 Cys Asp Ser Ala Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr His His 180 185 190 Ile Glu Arg Met Asp Phe Phe Leu Ser Phe Leu Phe Val Leu Ala Thr 195 200 205 Met Met Leu Ile Ile Val Ser Tyr Phe Leu Ile Val Ala Ala Val Leu 210 215 220 Arg Ile Pro Ser Phe Ser Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Val Val Val Leu Gly Tyr Gly Ser Thr Ile Phe Ile 245 250 255 Tyr Val Arg Pro Gly Lys Gly His Ser Thr His Leu Asn Lys Val Val 260 265 270 Ala Leu Met Thr Ala Val Val Thr Pro Phe Leu Asn Pro Phe Ile Phe 275 280 285 Thr Phe Arg Asn Glu Lys Phe Lys Glu Val Ile Glu Asp Met Thr Lys 290 295 300

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Arg Leu Arg Phe Arg Asp Ala Ala Ala His Arg 305 310 315 <210> 361 <211> 966 <212> DNA <213> Canis familiaris <400> 361

atgcagggac ccagctcctg gatcatggca aatctgagcc acccttctga atttgtcctc 60 ttgggcttct cctcttttgg caagcttcag gttctgctgt atggaccctt actcatgctt 120 tatcttcttg ccttcgtggg aaacacagtc atcatagtca tggtcatagc aaacacccac 180 ctacatacgc ccatgtactt ctttctgggt aacttttcac tgctggagat cttggtaacc 240 atgacagcag tgcctaagat gctctcagac ctgctgactt cccacaaagt catttccttc 300 aatggctgca tggtccagtt ctacttctac ttttccctgg gttccacctc cttcctcatc 360 ctgtcagaca tggcccttga ccgctttatg gccatctgcc acccactgcg ctatggcact 420 ttgatgagct gggctgtgtg tgtccggctg gcaggagttg cctgggcagc tcctttcctg 480 gccatggtgc ccactgtcct ctcccgggct tatctcaatt attgccataa caacatcatt 540 aaccacttct tctgtgacaa tgcacctctg ctacagctgt cctgctcaga caccaggctg 600 ctggaattct gggactttgt gatggccttg gcctttgtcc tcagttcctt cctagtgacc 660 ctcatctcct atggctatat tgtgaccact gtgctgagga tcccatctgc tagtggccgc 720 cataaggctt tctctacatg tgggtcacat ctcacccttg tcttcattgg ctacagcagc 780 accatcttcc tttatgtcag gcttggcaaa acacattctg tggaagtcaa caagaccgta 840 gccttggtga catcggtcct cactcccttt ctcaatccct ttatccttac cttccgcaat 900 gagacagtca aggcagtgct acaggggcag atgcagaggc ttaaaggcct ccacaaggga 960

ctatga 966 <210> 362 <211> 321 <212> PRT <213> Canis familiaris <400> 362

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Met 1 Gln Gly Pro Ser 5 Ser Trp Ile Met Ala Asn Leu Ser His Pro Ser 10 15 Glu Phe Val Leu Leu Gly Phe Ser Ser Phe Gly Lys Leu Gln Val Leu 20 25 30 Leu Tyr Gly Pro Leu Leu Met Leu Tyr Leu Leu Ala Phe Val Gly Asn 35 40 45 Thr Val Ile Ile Val Met Val Ile Ala Asn Thr His Leu His Thr Pro 50 55 60 Met Tyr Phe Phe Leu Gly Asn Phe Ser Leu Leu Glu Ile Leu Val Thr 65 70 75 80 Met Thr Ala Val Pro Lys Met Leu Ser Asp Leu Leu Thr Ser His Lys 85 90 95 Val Ile Ser Phe Asn Gly Cys Met Val Gln Phe Tyr Phe Tyr Phe Ser 100 105 110 Leu Gly Ser Thr Ser Phe Leu Ile Leu Ser Asp Met Ala Leu Asp Arg 115 120 125 Phe Met Ala Ile Cys His Pro Leu Arg Tyr Gly Thr Leu Met Ser Trp 130 135 140 Ala Val Cys Val Arg Leu Ala Gly Val Ala Trp Ala Ala Pro Phe Leu 145 150 155 160 Ala Met Val Pro Thr Val Leu Ser Arg Ala Tyr Leu Asn Tyr Cys His 165 170 175 Asn Asn Ile Ile Asn His Phe Phe Cys Asp Asn Ala Pro Leu Leu Gln 180 185 190 Leu Ser Cys Ser Asp Thr Arg Leu Leu Glu Phe Trp Asp Phe Val Met 195 200 205

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Ala Leu 210 Ala Phe Val Leu Ser 215 069269_0225_SL.TXT Ser Phe Leu Val Thr Leu 220 Ile Ser Tyr Gly Tyr Ile Val Thr Thr Val Leu Arg Ile Pro Ser Ala Ser Gly Arg 225 230 235 240 His Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Leu Val Phe Ile 245 250 255 Gly Tyr Ser Ser Thr Ile Phe Leu Tyr Val Arg Leu Gly Lys Thr His 260 265 270 Ser Val Glu Val Asn Lys Thr Val Ala Leu Val Thr Ser Val Leu Thr 275 280 285 Pro Phe Leu Asn Pro Phe Ile Leu Thr Phe Arg Asn Glu Thr Val Lys 290 295 300 Ala Val Leu Gln Gly Gln Met Gln Arg Leu Lys Gly Leu His Lys Gly 305 310 315 320

Leu <210> 363 <211> 942 <212> DNA <213> Canis familiaris <400> 363 atgaacaact tgtctagtgc cactgagttc taccttctag gcttccccgg gtcccaagaa ctacaccaca ttctttttgc tatattcttt ttctcctact cagtgacatt agtgggaaac acagtcatca ttgtgattgt gtgtgttgat aaacgtctgc agtcccccat gtatttcttc cttggtcacc tctctgcttc ggagatctta attacaacta ttatcgttcc tatgatgctt tgggggttgc tactccctgg gatgcagacg atatctttgg ctgcatgtgc cacccagctc ttcctgtacc ttgctgtggc gactacagag tttgcattac tgggagcgat ggctgtggac cgttacgtgg ctgtctgtaa ccctttgagg tacaatgtca ttatgaacag ccgcacctgc

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atctgggtgg tcattgtgtc ctggacattt gggtttcttt ctgaaatatg gcctgtctat 480 gccacatttc agtttacctt ctgcaagtcc aatctgttag accatttttt ctgtgaccga 540 gggcaactgt tcaaactatc ctgtgatgac acccttttca cagagtttgt tcttttctta 600 atggctattg tcattatcat tggttctctg gccccaacag ttatctccta cacctacatc 660 atctgcacca tcctcaggat gcccacagcc tcaggccaga ggaaagcctt ctctacatgt 720 gcttctcatt tcactgttgt tgttattatg tatggcagct gcttgtttat ccatgtgaaa 780 cctaagctaa cgcaggcagc ggagtataat aaaatagttt ccctgttgat ttctgtgtta 840 acccctttcc tgaatccttt catcttcacc ctcaggaacg acaaagtcaa agaggccctt 900 tgggatctta tgaaatgctg taatcaactc ttcaaaggtt ga 942

<210> 364 <211> 313 <212> PRT <213> Canis familiaris <400> 364

Met Asn Asn Leu Ser Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe Pro 1 5 10 15 Gly Ser Gln Glu Leu His His Ile Leu Phe Ala Ile Phe Phe Phe Ser 20 25 30 Tyr Ser Val Thr Leu Val Gly Asn Thr Val Ile Ile Val Ile Val Cys 35 40 45 Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Gly His Leu 50 55 60 Ser Ala Ser Glu Ile Leu Ile Thr Thr Ile Ile Val Pro Met Met Leu 65 70 75 80 Trp Gly Leu Leu Leu Pro Gly Met Gln Thr Ile Ser Leu Ala Ala Cys 85 90 95 Ala Thr Gln Leu Phe Leu Tyr Leu Ala Val Ala Thr Thr Glu Phe Ala 100 105 110

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Leu Leu Gly 115 Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn Pro 120 125 Leu Arg Tyr Asn Val Ile Met Asn Ser Arg Thr Cys Ile Trp Val Val 130 135 140 Ile Val Ser Trp Thr Phe Gly Phe Leu Ser Glu Ile Trp Pro Val Tyr 145 150 155 160 Ala Thr Phe Gln Phe Thr Phe Cys Lys Ser Asn Leu Leu Asp His Phe 165 170 175 Phe Cys Asp Arg Gly Gln Leu Phe Lys Leu Ser Cys Asp Asp Thr Leu 180 185 190 Phe Thr Glu Phe Val Leu Phe Leu Met Ala Ile Val Ile Ile Ile Gly 195 200 205 Ser Leu Ala Pro Thr Val Ile Ser Tyr Thr Tyr Ile Ile Cys Thr Ile 210 215 220 Leu Arg Met Pro Thr Ala Ser Gly Gln Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ser His Phe Thr Val Val Val Ile Met Tyr Gly Ser Cys Leu Phe 245 250 255 Ile His Val Lys Pro Lys Leu Thr Gln Ala Ala Glu Tyr Asn Lys Ile 260 265 270 Val Ser Leu Leu Ile Ser Val Leu Thr Pro Phe Leu Asn Pro Phe Ile 275 280 285 Phe Thr Leu Arg Asn Asp Lys Val Lys Glu Ala Leu Trp Asp Leu Met 290 295 300 Lys Cys Cys Asn Gln Leu Phe Lys Gly 305 310

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069269_0225_SL.TXT <210> 365 <211> 933 <212> DNA <213> Canis familiaris <400> 365

atgggagaca atatgacata tatcacagag ttcaccctac tgggatttcc tcttggccca 60 aggattcaga tggttctctt tgggctcttc accctgttct atgccttcac cctgctgggg 120 aatgggctca tcctggggct catctcactg gaccccagac tgcacacccc catgtacttc 180 ttcctctccc acctggccat cgtcgacata gcctatgcct gcaacacggt gccccagatg 240 ctggtgaacc tcctgaggcc agacaagccc atctcctttg ctggctgcct gacgcagacc 300 tttctctttc tgacctttgc tgtcacagaa tgtcttctcc tggtggtgat gtcctatgac 360 cggtatgtgg ccatttgcca ccccctccgc tattctgtga tcatgagctg gagagtctgc 420 atcaccctgg tgctgacttc ttggaccatt ggagtccttc tgtctttggt tcatctcatg 480 ttacttctcc ccttaccctt ctgtagattc cagaaaatca atcacttttt ctgtgaaatc 540 atggctgttc tcaaacttgt ctgtgcagat acccacatca atgagattat ggtattggct 600 ggagcaattt ctgtgctagt gggacccttc tcctcaattg taatctccta tatgtgcatt 660 ttctgtgcca tccttagaat ccagtctgga gaaggtcaaa gaaaagcctt ctccacctgc 720 tcatctcatc tctgtgtggt tggactcttt tacggcacag ccatcataat gtatgttggg 780 cccagatatg ggaaccccaa ggagcagaag aaatacctgc tcctgtttca cagccttttc 840 aaccccatgc tcaaccccct tatctatagt cttaggaact tagaagtgaa aaatgccttg 900 aagagagtgc tgggaataca gagagcttta tga 933

<210> 366 <211> 310 <212> PRT <213> Canis familiaris <400> 366

Met Gly Asp Asn Met Thr Tyr Ile Thr Glu Phe Thr Leu Leu Gly Phe

1 5 10 15

Pro Leu Gly Pro Arg Ile Gln Met Val Leu Phe Gly Leu Phe Thr Leu

20 25 30

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Phe Tyr Ala 35 Phe Thr Leu Leu Gly Asn Gly Leu Ile Leu Gly Leu Ile 40 45 Ser Leu Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Ile Val Asp Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met 65 70 75 80 Leu Val Asn Leu Leu Arg Pro Asp Lys Pro Ile Ser Phe Ala Gly Cys 85 90 95 Leu Thr Gln Thr Phe Leu Phe Leu Thr Phe Ala Val Thr Glu Cys Leu 100 105 110 Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu Arg Tyr Ser Val Ile Met Ser Trp Arg Val Cys Ile Thr Leu Val 130 135 140 Leu Thr Ser Trp Thr Ile Gly Val Leu Leu Ser Leu Val His Leu Met 145 150 155 160 Leu Leu Leu Pro Leu Pro Phe Cys Arg Phe Gln Lys Ile Asn His Phe 165 170 175 Phe Cys Glu Ile Met Ala Val Leu Lys Leu Val Cys Ala Asp Thr His 180 185 190 Ile Asn Glu Ile Met Val Leu Ala Gly Ala Ile Ser Val Leu Val Gly 195 200 205 Pro Phe Ser Ser Ile Val Ile Ser Tyr Met Cys Ile Phe Cys Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Gln Arg Lys Ala Phe Ser Thr Cys 225 230 235 240

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Ser Ser His Leu Cys 245 Val Val Gly Met Tyr Val Gly 260 Pro Arg Tyr Gly Leu Leu Leu 275 Phe His Ser Leu Phe 280 Tyr Ser 290 Leu Arg Asn Leu Glu 295 Val Gly 305 Ile Gln Arg Ala Leu 310

Leu Phe 250 Tyr Gly Thr Ala Ile 255 Ile Asn 265 Pro Lys Glu Gln Lys 270 Lys Tyr Asn Pro Met Leu Asn 285 Pro Leu Ile Lys Asn Ala Leu 300 Lys Arg Val Leu

<210> 367 <211> 834 <212> DNA <213> Canis familiaris <400> 367 ttcctcttct ggatcttctc cctcttttat tttggactcc tctgtctaga ttctagactg tcacacctgt ccatcattga catgtcctat aaacttagtg aatcagaaga gaaccatacc ttagcttttg ctcacaaaga gtgcctgatc gagatctgcc acccactcta gcacactgtc gtcattgctt cctggacacg tggatttatt aggctgcctt tctgtggacc tcggaagtag tcaaactggc ctgtgctgat acctgaatca atcttagttg ggcccctttg tttgggtgct cctgaaaatc catcaggaga aagctgaaga tgtgtgatta ggcttgtcac tgtgatggtg gtcttcagtc tgctggggaa tggcatgatc cacaccccta tgtacttttt ttttttcctt gcttccaaca atgtccccca agatgctcac ttttgttcca tgcataatac atttttgtat ttggtggtga tgtcctatga taggtttgta atcgtaagct ggagagtgtg cacagtcttg ctgtctctgg tacatgcaat tctcctttta accacatctt ctgtgaaatc ctgtctgttc atgaagctat catctgctgc ctgtatattt agtctcctat actagcatcc tctggaccat aaagccttct ccacctactc ttctcacctc gtttatatgg ttccagactc tagtcagaga

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069269_0225_SL.TXT aaggaacagg agaaaatgct cttcctgttt catagtctct tcaatccaat gctgaatccc 780 ttcatctaca gcctcaagaa tgttcaggtg aagaatgcct tgtatagagc attg 834 <210> 368 <211> 106 <212> PRT <213> Canis familiaris <400> 368

Phe Leu Phe Trp Ile Phe Ser Leu Phe Tyr Val Phe Ser Leu Leu Gly 1 5 10 15 Asn Gly Met Ile Phe Gly Leu Leu Cys Leu Asp Ser Arg Leu His Thr 20 25 30 Pro Met Tyr Phe Phe Phe Phe Leu Ser His Leu Ser Ile Ile Asp Met 35 40 45 Ser Tyr Ala Ser Asn Asn Val Pro Gln Asp Ala His Lys Leu Ser Glu 50 55 60 Ser Glu Glu Asn His Thr Phe Cys Ser Met His Asn Thr Phe Leu Tyr 65 70 75 80 Leu Ala Phe Ala His Lys Glu Cys Leu Ile Leu Val Val Met Ser Tyr 85 90 95 Asp Arg Phe Val Glu Ile Cys His Pro Leu 100 105

<210> 369 <211> 933 <212> DNA <213> Canis familiaris <400> 369 atggagggca accaatcatg gatcacggaa tttatcctag tgggattcca gctcagtgaa 60 gacattgaag tgctcctctt ttgtatcttc tccctgttct atatctttaa tttgctggca 120 aatggcatga tcttgggact catttggcta gacctcagac tgcactcccc catgtatttc 180 ttactttctc atctggctat cattgacata tgctatgctt ccagcaatct gcccaatatg 240

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069269_0225_SL.TXT ctggaaaacc tagtgaagca gttttgtttg tgacttttgc cggtttgtgg cgatctgcca gtggtcctgg tcattgctac ctcttcctaa agttgacatt ctctctgtcc tcaaagtggc ggtggcatgt ttgtcttagt ctctgggcca tcctgaagat tcctcccact tctgtgtggt ccagacaata gccaacgtga aacccattgc tgaaccctct aacaaagcat tgcaaaaaaa <210> 370 <211> 310 <212> PRT <213> Canis familiaris <400> 370

Met 1 Glu Gly Asn Gln 5 Ser Gln Leu Ser Glu 20 Asp Ile Phe Tyr Ile 35 Phe Asn Leu Trp Leu 50 Asp Leu Arg Leu Leu 65 Ala Ile Ile Asp Ile 70

caagaaaacg atctcctttg tggtgcagag tgcctgattt tcctctccag tacaccgtca ctgggcatgt gggttttcct ctgtgggccc caggaagtga ctgtggtgac acttggatca tgggcccctt tctctgatgt ccaaacaaag gaagggcgca tggattctac tttggcatag ggagcagcag aaaatcctta catttacagt ctgagaaatg gaggacaata taa

Trp Ile Thr Glu Phe 10

Glu Val Leu Leu Phe 25

Leu Ala Asn Gly Met 40

His Ser Pro Met Tyr 55

Cys Tyr Ala Ser Ser 75 tctcatgtac tatgcagata tggtagtgat ggcctacgac tcatgaactg gagagtgtgc tggccctagt gcatctaatt accacttctt ctgtgaaatc atgaagcctt agtctttgct tggtctccta tatgcgcatc gaaaagcctt ttccacctgc ccatgatggt ttatttggtt ccctgtttta caccctcttc ctcagatgaa ggctgccttc

Ile Leu Val Gly 15 Phe Cys Ile Phe 30 Ser Leu Ile Leu 45 Gly Leu Ile Phe 60 Leu Leu Ser His Asn Leu Pro Asn Met 80

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Leu Glu Asn Leu Val 85 Lys His Lys Lys Thr Ile Ser Phe Val Ser Cys 90 95 Thr Met Gln Ile Val Leu Phe Val Thr Phe Ala Gly Ala Glu Cys Leu 100 105 110 Ile Leu Val Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro 115 120 125 Leu Gln Tyr Thr Val Ile Met Asn Trp Arg Val Cys Val Val Leu Val 130 135 140 Ile Ala Thr Trp Ala Cys Gly Phe Ser Leu Ala Leu Val His Leu Ile 145 150 155 160 Leu Phe Leu Lys Leu Thr Phe Cys Gly Pro Gln Glu Val Asn His Phe 165 170 175 Phe Cys Glu Ile Leu Ser Val Leu Lys Val Ala Cys Gly Asp Thr Trp 180 185 190 Ile Asn Glu Ala Leu Val Phe Ala Gly Gly Met Phe Val Leu Val Gly 195 200 205 Pro Leu Ser Leu Met Leu Val Ser Tyr Met Arg Ile Leu Trp Ala Ile 210 215 220 Leu Lys Ile Gln Thr Lys Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Phe Cys Val Val Gly Phe Tyr Phe Gly Ile Ala Met Met 245 250 255 Val Tyr Leu Val Pro Asp Asn Ser Gln Arg Glu Glu Gln Gln Lys Ile 260 265 270 Leu Thr Leu Phe Tyr Thr Leu Phe Asn Pro Leu Leu Asn Pro Leu Ile 275 280 285

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Tyr Ser Leu Arg Asn Ala Gln Met Lys Ala Ala Phe Asn Lys Ala Leu 290 295 300

Gln Lys Lys Arg Thr Ile 305 310 <210> 371 <211> 930 <212> DNA <213> Canis familiaris <400> 371 atgggaagca accagtcatg ggtcacagaa tttgtcttgg tggggttcca gctcagtgca 60 gagatggaag tgctcctctt ctggatcttt tccctcttgt atatcttcag tctgctggca 120 aatggcgtga tcttgggact catccatctg gacctgagac tgcacacccc catgtacttc 180 ttcctctcac acctggctgt catcgacatg tcctatgcct ccaacaatgt ccccaagatg 240 ttggtaaact tagtgaatca gaagagaacc atctcttttg ttccctgcgt aatgcagaca 300 tttctgtacc tgggttttgc tgctacagag tgcctggttt tggtggtgat gtcctatgac 360 aggtacgtgg ccatctgcca ccccctccag tacactgtca tcatgagctg gagactgtgc 420 acggttctgg ctgtcacttc ctggtcatgt ggattttttc tgtctctggt acatgcaatt 480 ctccttctac ggttgccctt ctgtggaccc aggaaagtaa accacctttt ctgtgaaatc 540 ctatctgtcc tcaagctggc ctgtgctgac actaggctca accaaatggt catctttgct 600 gcctgtatgt ttgtcttagt tgtgcctctc tgcttaatgc tagtttccta catgtgcatc 660 ctctgggcca tcctaaagat ccagtcaaag cagggccgca gaaaggcctt ctccacctgc 720 tcttcccacc tctgtgtggt tggactcttc tttggcatag ccatgttggt ttatatggtc 780 cccgactcca atcaacgaga agagctagag aaaatactgt ccctatttca cagtctcttt 840 aacccaatgc tgaaccctct catctacagc ttgaggaatg ctcagatgaa ggcttctttg 900 tatagagtac tgcagaaaaa aaccatgtga 930 <210> 372 <211> 309 <212> PRT <213> Canis familiaris

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<400> 372 Gln Ser Trp Val Thr Glu Phe Val Leu Val Gly 15 Phe Met 1 Gly Ser Asn 5 10 Gln Leu Ser Ala Glu Met Glu Val Leu Leu Phe Trp Ile Phe Ser Leu 20 25 30 Leu Tyr Ile Phe Ser Leu Leu Ala Asn Gly Val Ile Leu Gly Leu Ile 35 40 45 His Leu Asp Leu Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Val Ile Asp Met Ser Tyr Ala Ser Asn Asn Val Pro Lys Met 65 70 75 80 Leu Val Asn Leu Val Asn Gln Lys Arg Thr Ile Ser Phe Val Pro Cys 85 90 95 Val Met Gln Thr Phe Leu Tyr Leu Gly Phe Ala Ala Thr Glu Cys Leu 100 105 110 Val Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu Gln Tyr Thr Val Ile Met Ser Trp Arg Leu Cys Thr Val Leu Ala 130 135 140 Val Thr Ser Trp Ser Cys Gly Phe Phe Leu Ser Leu Val His Ala Ile 145 150 155 160 Leu Leu Leu Arg Leu Pro Phe Cys Gly Pro Arg Lys Val Asn His Leu 165 170 175 Phe Cys Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Arg 180 185 190 Leu Asn Gln Met Val Ile Phe Ala Ala Cys Met Phe Val Leu Val Val 195 200 205

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Pro Leu Cys Leu Met Leu Val Ser Tyr Met Cys Ile Leu Trp Ala Ile 210 215 220 Leu Lys Ile Gln Ser Lys Gln Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ile Ala Met Leu 245 250 255 Val Tyr Met Val Pro Asp Ser Asn Gln Arg Glu Glu Leu Glu Lys Ile 260 265 270 Leu Ser Leu Phe His Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Ala Gln Met Lys Ala Ser Leu Tyr Arg Val Leu 290 295 300 Gln Lys Lys Thr Met

305 <210> 373 <211> 933 <212> DNA <213> Canis familiaris <400> 373

atgggaagca accagtcatg ggtcacagaa tttgtcttgg tggggttcca gctcagtgca 60 gagatggaag tgctcctctt ctggatcttc tccctcttgt atatcttcag tctgctggca 120 aatggcgtga tcttgggact catccgtctg gacctgagac tgcacacccc catgtacttc 180 ttcctctcac acctggctgt catcgacatg tcctatgcct ccaacaatgt ccccaagatg 240 ttggtaaact tagtgaatca gaagagaacc atctcttttg ttccctgcgt aatgcagaca 300 tttctgtacc tgggttttgc tgctacagag tgcctggttt tggtggtgat gtcctatgac 360 aggtacgtgg ccatctgcca ccccctccag tacactgtca tcatgagctg gagactgtgc 420 atggtcctgg ctgtcacttc ttgggtgttt agcttcctct tggccctcgt ccatttaatt 480 ctcatcctga ggctgccctt ctgtgggcct catgaaatca accacttctt ctgtgaaatc 540

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069269_0225_SL.TXT ttatctgtcc tcaagctggc ctgtgctgac actaggctca accaagtggt catctttggg acctgtgtgt ttatcttagt ggggcctctc tgcttggtgc tggtgtccta ctcatgcatc ctgtttgcca tcctgaggat ccagtctggg gaaggccgca gaaaggcctt ctccacctgt tcctcccacc tctgcgtggt ggggctctac tttggcagcg ccattgtcat gtacatggcc cccaaatcca accacccaga ggagaagcag aagatccttt ccctgtttta tagccttttc aaccctatgc tgaacccact gatctacagt ctgaggaaca cagaggtgaa gggtgccctg aggagagcct tatacaggca taggcatata tga

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933 <210> 374 <211> 310 <212> PRT <213> Canis familiaris <400> 374

Met Gly 1 Ser Asn Gln Ser Trp Val Thr Glu Phe Val Leu Val Gly Phe 5 10 15 Gln Leu Ser Ala Glu Met Glu Val Leu Leu Phe Trp Ile Phe Ser Leu 20 25 30 Leu Tyr Ile Phe Ser Leu Leu Ala Asn Gly Val Ile Leu Gly Leu Ile 35 40 45 Arg Leu Asp Leu Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Val Ile Asp Met Ser Tyr Ala Ser Asn Asn Val Pro Lys Met 65 70 75 80 Leu Val Asn Leu Val Asn Gln Lys Arg Thr Ile Ser Phe Val Pro Cys 85 90 95 Val Met Gln Thr Phe Leu Tyr Leu Gly Phe Ala Ala Thr Glu Cys Leu 100 105 110 Val Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125

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Leu Gln 130 Tyr Thr Val Ile Met Ser Trp Arg Leu Cys Met Val Leu Ala 135 140 Val Thr Ser Trp Val Phe Ser Phe Leu Leu Ala Leu Val His Leu Ile 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro His Glu Ile Asn His Phe 165 170 175 Phe Cys Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Arg 180 185 190 Leu Asn Gln Val Val Ile Phe Gly Thr Cys Val Phe Ile Leu Val Gly 195 200 205 Pro Leu Cys Leu Val Leu Val Ser Tyr Ser Cys Ile Leu Phe Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Tyr Phe Gly Ser Ala Ile Val 245 250 255 Met Tyr Met Ala Pro Lys Ser Asn His Pro Glu Glu Lys Gln Lys Ile 260 265 270 Leu Ser Leu Phe Tyr Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Thr Glu Val Lys Gly Ala Leu Arg Arg Ala Leu 290 295 300 Tyr Arg His Arg His Ile

305 310 <210> 375 <211> 933

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069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 375 atgggaggca accagacatg gatcacagaa gtcatcctgc tgggattcca ggtcgatcca 60 gcactggagc tccttctctt tggacttttc tgtcttttct ataccctcac ccttctggga 120 aatggagtca tcttagggct tatctgctta gacgctagac tgcacagccc catgtacttc 180 ttcctcactc acctggcaat tgttgacatg tcctacgcct ccaataatgt ccccaagatg 240 ctggcaaatc ttgtgaatct gaaaagaacc atatcctttg ttccttgcat catgcagact 300 tttctgtatc tggcttttgc tcacatagag tgcctgattt tggttgtgat gtcctatgac 360 aggtttgtgg caatctgcca tcctctacat tacacagtca tcatgaactg gagaatgtgc 420 acagtcttag ccagcacttc ttgggttttt agcttcctct tggctctcgt ccatttaatt 480 ctcatcttga ggctgccctt ctgtgggcct catgaaatca accacttctt ctgtgaaatc 540 ctgtctgtcc tcaagctggc ctgtgctgac actaggctca accaagtggt catctttgct 600 gcctgtgtgt ttatcttagt gggacctctc tgcttggtgc tggtgtccta ctcatgcatc 660 ctgtttgcca tcctgagaat ccagtctggg gaaggccgca gaaaggcctt ctccacctgt 720 tcctcccacc tctgcgtggt ggggctcttc tttggcagcg ccattgtcat gtacatggcc 780 cccaaatcca accaccctga ggagcagcag aagatccttt ctctgtttta tagccttttc 840 aaccctatgc tgaacccact gatctacagt ctgaggaaca cagaggtgaa gggtgccctg 900 aggagagtct tatacaggca gaggcatata tga 933 <210> 376 <211> 310 <212> PRT <213> Canis familiaris <400> 376

Met Gly Gly Asn Gln Thr Trp Ile Thr Glu Val Ile Leu Leu Gly Phe 1 5 10 15 Gln Val Asp Pro Ala Leu Glu Leu Leu Leu Phe Gly Leu Phe Cys Leu 20 25 30 Phe Tyr Thr Leu Thr Leu Leu Gly Asn Gly Val Ile Leu Gly Leu Ile

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069269_0225_SL.TXT 40 45

Cys Leu 50 Asp Ala Arg Leu His Ser Pro Met Tyr Phe Phe Leu Thr His 55 60 Leu Ala Ile Val Asp Met Ser Tyr Ala Ser Asn Asn Val Pro Lys Met 65 70 75 80 Leu Ala Asn Leu Val Asn Leu Lys Arg Thr Ile Ser Phe Val Pro Cys 85 90 95 Ile Met Gln Thr Phe Leu Tyr Leu Ala Phe Ala His Ile Glu Cys Leu 100 105 110 Ile Leu Val Val Met Ser Tyr Asp Arg Phe Val Ala Ile Cys His Pro 115 120 125 Leu His Tyr Thr Val Ile Met Asn Trp Arg Met Cys Thr Val Leu Ala 130 135 140 Ser Thr Ser Trp Val Phe Ser Phe Leu Leu Ala Leu Val His Leu Ile 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro His Glu Ile Asn His Phe 165 170 175 Phe Cys Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Arg 180 185 190 Leu Asn Gln Val Val Ile Phe Ala Ala Cys Val Phe Ile Leu Val Gly 195 200 205 Pro Leu Cys Leu Val Leu Val Ser Tyr Ser Cys Ile Leu Phe Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val

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245 250 255 Met Tyr Met Ala Pro Lys Ser Asn His Pro Glu Glu Gln Gln Lys Ile 260 265 270 Leu Ser Leu Phe Tyr Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Thr Glu Val Lys Gly Ala Leu Arg Arg Val Leu 290 295 300 Tyr Arg Gln Arg His Ile 305 310

<210> 377 <211> 933 <212> DNA <213> Canis familiaris <400> 377 atgggaagca atcagacatg gatcacagaa gtcatcctgc tgggattcca ggttgatccc aaacttgaaa tattcctctt tgggttcttc ttgctattct atagccttac cttgatgggg aacgggctca tcctggggct catctggctg gactccagac tgcacacgcc catgtacttc ttcctctcaa acctggccat tgttgacatg tcctatgcct caagcattgt ccctaagatg ctggcaagtc ttataatgca gaagaaaacc atctcctttg ttccatgcat acttcagaca tttttgtatt tggcacttgc tgtcacagag tgtatgagtt tggtggtcat gtcctatgat cggtatgtgg ccatctgcca tcccctacat tacactgtcg tcatgagctg gagagtgtgc attatcttgt ctgccacttg ctggatgttc agctttctct tggctctggt ccacattact ctgattctta agttgccttt ttgtggacca caaaaaatca accacttttt ctgtcaaatc atgtcggtat ttaaattggc ctgtgctgac actagactca accaaattgt tctctttgcc ggctctgtgt ttgttttagt cgcacccctc tgcttggtgc tggtatccta tattcatatc ctgttggcca tcttgaggat ccagtctggg gagggtcgca gaaaggcctt ctccacctgc tcctcccacc tctgtgtggt ggggctcttc tttggcagtg ctattgttat gtacctggcc cctaaatcta gccattctca agaacaaaga aagattttat cattgtttta tagccttttc Page 423

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069269_0225_SL.TXT aatcctatgc taaacccact gatcaacagc ctgaggaaca ctgaggtgaa gagtgccctg aggagatttc tagggaagaa gtcatcagca tga

900

933 <210> 378 <211> 310 <212> PRT <213> Canis familiaris <400> 378

Met Gly 1 Ser Asn Gln Thr Trp Ile Thr Glu Val Ile Leu Leu Gly Phe 5 10 15 Gln Val Asp Pro Lys Leu Glu Ile Phe Leu Phe Gly Phe Phe Leu Leu 20 25 30 Phe Tyr Ser Leu Thr Leu Met Gly Asn Gly Leu Ile Leu Gly Leu Ile 35 40 45 Trp Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn 50 55 60 Leu Ala Ile Val Asp Met Ser Tyr Ala Ser Ser Ile Val Pro Lys Met 65 70 75 80 Leu Ala Ser Leu Ile Met Gln Lys Lys Thr Ile Ser Phe Val Pro Cys 85 90 95 Ile Leu Gln Thr Phe Leu Tyr Leu Ala Leu Ala Val Thr Glu Cys Met 100 105 110 Ser Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu His Tyr Thr Val Val Met Ser Trp Arg Val Cys Ile Ile Leu Ser 130 135 140 Ala Thr Cys Trp Met Phe Ser Phe Leu Leu Ala Leu Val His Ile Thr 145 150 155 160

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Leu Ile Leu Lys Leu 165 Pro Phe Cys Gly Pro Gln Lys Ile Asn His Phe 170 175 Phe Cys Gln Ile Met Ser Val Phe Lys Leu Ala Cys Ala Asp Thr Arg 180 185 190 Leu Asn Gln Ile Val Leu Phe Ala Gly Ser Val Phe Val Leu Val Ala 195 200 205 Pro Leu Cys Leu Val Leu Val Ser Tyr Ile His Ile Leu Leu Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val 245 250 255 Met Tyr Leu Ala Pro Lys Ser Ser His Ser Gln Glu Gln Arg Lys Ile 260 265 270 Leu Ser Leu Phe Tyr Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Asn Ser Leu Arg Asn Thr Glu Val Lys Ser Ala Leu Arg Arg Phe Leu 290 295 300 Gly Lys Lys Ser Ser Ala 305 310

<210> 379 <211> 945 <212> DNA <213> Canis familiaris <400> 379 atgttgggga atcagtctag tgccactgaa ttttatctcc ttggcttccc tggctccaag gatctacacc atcttctctt tgctaccttc ttcttcttct actcagtgac attaatggga aacatggtca tcatcttgat tgtgtgtgct gataaacgtc tgcagtcccc catgtatttc

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ttccttagtc acctctctgc cttggagatc ttggttacat ctgttattgt gcctgtgatg 240 ctttgggggt tgctgctccc tgggatgcag acgatatctt tggctgcatg tgtcacccag 300 ctcttcctgt acctttctct ggggaccacc gagtttgcat tactgggagc aatggctgtg 360 gaccgttacg tggctgtctg taaccctttg aggtacaatg tcattatgaa cagccgcacc 420 tgtatctggg tggtcattgt gtcatgggtg tttggtttcc tatttcaaat ctggccagtg 480 tatgccacat ttcagcttac gttctgcaaa tccaatgtgg tgaacaattt cttctgtgac 540 cgagggcaat tgctcaaact atcctgcaac aatactcttt tcatagagtt tattctattc 600 ctaatggctg tctttgttct ttttggttct ctgatcccta caatcatctc ctacacctac 660 atcatctcca ccatcctcaa gattccctca gcctctgggc gaaggaaagc cttttctacg 720 tgtgcgtccc acttcacttg tgttgtgatc ggctatggca gttgcttgtt cctctatgtg 780 aaacccaagc aaacacaggc ggcagattac aatagagtgg tttccttgat ggtttcagtg 840 gttactcctt tcctcaaccc tttcatcttc acccttcgaa atgacaaagt catagaagcc 900 ctatgggatg gaatgaaaag atgctgtcaa ctattcaata actaa 945

<210> 380 <211> 314 <212> PRT <213> Canis familiaris <400> 380

Met 1 Leu Gly Asn Gln Ser 5 Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe 10 15 Pro Gly Ser Lys Asp Leu His His Leu Leu Phe Ala Thr Phe Phe Phe 20 25 30 Phe Tyr Ser Val Thr Leu Met Gly Asn Met Val Ile Ile Leu Ile Val 35 40 45 Cys Ala Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ser Ala Leu Glu Ile Leu Val Thr Ser Val Ile Val Pro Val Met 65 70 75 80

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Leu Trp Gly Leu Leu 85 Leu Pro Gly Met Gln Thr Ile Ser Leu Ala Ala 90 95 Cys Val Thr Gln Leu Phe Leu Tyr Leu Ser Leu Gly Thr Thr Glu Phe 100 105 110 Ala Leu Leu Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Asn Val Ile Met Asn Ser Arg Thr Cys Ile Trp Val 130 135 140 Val Ile Val Ser Trp Val Phe Gly Phe Leu Phe Gln Ile Trp Pro Val 145 150 155 160 Tyr Ala Thr Phe Gln Leu Thr Phe Cys Lys Ser Asn Val Val Asn Asn 165 170 175 Phe Phe Cys Asp Arg Gly Gln Leu Leu Lys Leu Ser Cys Asn Asn Thr 180 185 190 Leu Phe Ile Glu Phe Ile Leu Phe Leu Met Ala Val Phe Val Leu Phe 195 200 205 Gly Ser Leu Ile Pro Thr Ile Ile Ser Tyr Thr Tyr Ile Ile Ser Thr 210 215 220 Ile Leu Lys Ile Pro Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu 245 250 255 Phe Leu Tyr Val Lys Pro Lys Gln Thr Gln Ala Ala Asp Tyr Asn Arg 260 265 270 Val Val Ser Leu Met Val Ser Val Val Thr Pro Phe Leu Asn Pro Phe 275 280 285

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Ile Phe Thr Leu Arg Asn Asp Lys Val Ile Glu Ala Leu Trp Asp Gly 290 295 300

Met Lys Arg Cys Cys Gln Leu Phe Asn Asn

305 310 <210> 381 <211> 945 <212> DNA <213> Canis familiaris <400> 381

atgttgaaga attattctag tgctgttgaa ttttatctac ttggcttcca tggctccaaa 60 gaacaacaca atattctttt tgccactttc ttctttctct actcagtgac agtcatgaga 120 aatatgctca tcatcgtgat tgtctgtgtt gataaacgtc tgcagtcccc catgtatttt 180 ttccttggcc acctctctgt cctagagatc ctgattacat cagttgccgt ccccttgatg 240 ctctgggggc tgctgcttcc tgagatgcag gcaatatctt tgccagcctg cagtgcacaa 300 ttatatttgt acctttcttt gggtacatcg gagttggtat taattggagc aatggctgtg 360 gaccgttacg tggctgtctg taaccccttg aggtacaaca tcgttatgaa cagccacacc 420 tgcatctggg tggtcattgt gtcatgggtg tttgggttcc tatttcaaat ttggccagtg 480 tatgccacat ttcagcttac cttctgcaaa tcaaatgtat tagaccattt tttatgtgac 540 cgagggcaac tgctcaaatt atcctgtgat gacagccttt tcacagagtt tatccttttt 600 ttaatggctg tgttcattat tgttggttct ttgatcccta caatcatctc ctacacctac 660 atcatttcca ccatcctcaa gattccctca gcctctgggc ggaggaaagc cttttctacg 720 tgtgcgtccc acttcacctt tgtcgtgatc gggtatggca cctgcttgtt cctctatgtg 780 aaacccaagc aaacacaggc agcagagtat aatagggtag catcactgat ggttttagtg 840 gtgacccctt ttctgaaccc atttatcttc actctccgta atgacaaatt tattgaggcc 900 tttcgagatg tcatgaaacg ctgctatcat ctccacaagg gttag 945

<210> 382 <211> 314 <212> PRT <213> Canis familiaris

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069269_0225_SL.TXT <400> 382

Met 1 Leu Lys Asn Tyr Ser Ser Ala Val Glu Phe Tyr Leu Leu Gly Phe 5 10 15 His Gly Ser Lys Glu Gln His Asn Ile Leu Phe Ala Thr Phe Phe Phe 20 25 30 Leu Tyr Ser Val Thr Val Met Arg Asn Met Leu Ile Ile Val Ile Val 35 40 45 Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Gly His 50 55 60 Leu Ser Val Leu Glu Ile Leu Ile Thr Ser Val Ala Val Pro Leu Met 65 70 75 80 Leu Trp Gly Leu Leu Leu Pro Glu Met Gln Ala Ile Ser Leu Pro Ala 85 90 95 Cys Ser Ala Gln Leu Tyr Leu Tyr Leu Ser Leu Gly Thr Ser Glu Leu 100 105 110 Val Leu Ile Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Asn Ile Val Met Asn Ser His Thr Cys Ile Trp Val 130 135 140 Val Ile Val Ser Trp Val Phe Gly Phe Leu Phe Gln Ile Trp Pro Val 145 150 155 160 Tyr Ala Thr Phe Gln Leu Thr Phe Cys Lys Ser Asn Val Leu Asp His 165 170 175 Phe Leu Cys Asp Arg Gly Gln Leu Leu Lys Leu Ser Cys Asp Asp Ser 180 185 190 Leu Phe Thr Glu Phe Ile Leu Phe Leu Met Ala Val Phe Ile Ile Val 195 200 205

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Gly Ser Leu Ile Pro Thr Ile Ile Ser Tyr Thr Tyr Ile Ile Ser Thr 210 215 220 Ile Leu Lys Ile Pro Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Thr Phe Val Val Ile Gly Tyr Gly Thr Cys Leu 245 250 255 Phe Leu Tyr Val Lys Pro Lys Gln Thr Gln Ala Ala Glu Tyr Asn Arg 260 265 270 Val Ala Ser Leu Met Val Leu Val Val Thr Pro Phe Leu Asn Pro Phe 275 280 285 Ile Phe Thr Leu Arg Asn Asp Lys Phe Ile Glu Ala Phe Arg Asp Val 290 295 300 Met Lys Arg Cys Tyr His Leu His Lys Gly

305 310 <210> 383 <211> 723 <212> DNA <213> Canis familiaris <400> 383

atgttggaga atcgtagtgc cactgaattc tatctcttag gctttcctgg ctccccagaa 60 ttatatcata tcttatttgc taccttcttc ctcttccact cagtgacagt catggggaac 120 atggtcatca ttgtgactgt ccatgttgat aaatgtctgc agtcccccat gtacttcttc 180 cttggctacc actctgtcct ggagattcta tctacttcta tccccttgat gctctgaggg 240 ttgctgcttc ctgagattca ggcagtatct ttgacagcat gccatgtagt tatatttgta 300 cctttctttg ggcacatcag aatttatatt aatgggatca atggctgtgg accagtatgt 360 ggctatctgt aaccccttga gaaaaaacat cattatgaac agccacacct gcatctgggt 420 ggtcactgtg tcatgggtgt ttgggttcct atttcaaatc tggctactct ttgccacatt 480

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069269_0225_SL.TXT tcagcttacc ttctgaaaaa aaaaaagtta gacctttttt ttttatgtga tcgagggcaa ctgctcaaat tatcctgtga tgacagcctt ttcacagagt ttatcctttt ttaatgacta tattcattat ggttggttct tgtaccccta cctataattg tctcctatac ctacatcatc ttcacctcct caagatcccc tcagcctctg ggtggaggaa aaccttttct atgtgtgtgt cat <210> 384 <211> 78 <212> PRT <213> Canis familiaris <400> 384

Met 1 Leu Glu Asn Arg Ser 5 Ala Thr Glu Phe Tyr Leu Leu Gly Phe Pro 10 15 Gly Ser Pro Glu Leu Tyr His Ile Leu Phe Ala Thr Phe Phe Leu Phe 20 25 30 His Ser Val Thr Val Met Gly Asn Met Val Ile Ile Val Thr Val His 35 40 45 Val Asp Lys Cys Leu Gln Ser Pro Met Tyr Phe Phe Leu Gly Tyr His 50 55 60 Ser Val Leu Glu Ile Leu Ser Thr Ser Ile Pro Leu Met Leu 65 70 75

<210> 385 <211> 879 <212> DNA <213> Canis familiaris <400> 385 atgcacctgt tcctcttcag catggttgtg gtagtctaca cactagcgat ggctggcaac actgccatgg tcctcttgat ctgggctgat gcccggctcc acacacccat gtatttcctc ctcagccagt tgtctttcct ggacatcttc ttcacctcag tcaccgtccc caagatgata gcaggcttcc tctttggctg gactagcatc tcatttgtgg gctgtggggc acaaatgttt ttcttcatgt tccttggggc cgctgaatgc ctcctgctgg ccctcatggc ctatgaccgc Page 431

540

600

660

720

723

120

180

240

300

069269_0225_SL.TXT

tacgtggcca tctgcaaccc tctgcgctac ccatcactca tgagccacca gacctgtctg 360 ctcatggtgg ctgcctcctg gctgggtgga tccatcaatg cctccgtcca gacagcattg 420 accctacagt tcccctattg tggctcaagg aagattgcac actttttctg tgaggtgcct 480 tcgctgctga ggctggcctg tgctgacaca gcagcctatg agcaagtgct ctttgtgaca 540 ggtgttgtgg tccttctgct gcccattgcc ttcatcacca cctcctatgc cctcattctg 600 gcagcagtgc ttgggatgca ctccgtggag gggcgtcaga aggccctagc cacctgctcc 660 tcccacttaa cagttgtcaa cctcttctat gggcctcttg tgtataccta tatgttacct 720 gcatcttacc actctcctgg ccaggatgat gtagtgtcta tcttttatac agtcctcaca 780 cccatgctga accctgtcat ctacagcctc aggaacaagg aagtgacagg agcaatgaag 840 aaggtcatag ggaagtgtag ggtgggtagg actgcttaa 879

<210> 386 <211> 292 <212> PRT <213> Canis familiaris <400> 386

Met 1 His Leu Phe Leu 5 Phe Ser Met Val Val Val Val Tyr Thr Leu Ala 10 15 Met Ala Gly Asn Thr Ala Met Val Leu Leu Ile Trp Ala Asp Ala Arg 20 25 30 Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu Ser Phe Leu Asp 35 40 45 Ile Phe Phe Thr Ser Val Thr Val Pro Lys Met Ile Ala Gly Phe Leu 50 55 60 Phe Gly Trp Thr Ser Ile Ser Phe Val Gly Cys Gly Ala Gln Met Phe 65 70 75 80 Phe Phe Met Phe Leu Gly Ala Ala Glu Cys Leu Leu Leu Ala Leu Met 85 90 95

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Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Pro Ser 100 105 110 Leu Met Ser His Gln Thr Cys Leu Leu Met Val Ala Ala Ser Trp Leu 115 120 125 Gly Gly Ser Ile Asn Ala Ser Val Gln Thr Ala Leu Thr Leu Gln Phe 130 135 140 Pro Tyr Cys Gly Ser Arg Lys Ile Ala His Phe Phe Cys Glu Val Pro 145 150 155 160 Ser Leu Leu Arg Leu Ala Cys Ala Asp Thr Ala Ala Tyr Glu Gln Val 165 170 175 Leu Phe Val Thr Gly Val Val Val Leu Leu Leu Pro Ile Ala Phe Ile 180 185 190 Thr Thr Ser Tyr Ala Leu Ile Leu Ala Ala Val Leu Gly Met His Ser 195 200 205 Val Glu Gly Arg Gln Lys Ala Leu Ala Thr Cys Ser Ser His Leu Thr 210 215 220 Val Val Asn Leu Phe Tyr Gly Pro Leu Val Tyr Thr Tyr Met Leu Pro 225 230 235 240 Ala Ser Tyr His Ser Pro Gly Gln Asp Asp Val Val Ser Ile Phe Tyr 245 250 255 Thr Val Leu Thr Pro Met Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn 260 265 270 Lys Glu Val Thr Gly Ala Met Lys Lys Val Ile Gly Lys Cys Arg Val 275 280 285 Gly Arg Thr Ala

290

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069269_0225_SL.TXT <210> 387 <211> 906 <212> DNA <213> Canis familiaris <400> 387 atggagcaag gaaatgaatc ctccaccacg gatttcattc tccttagctt tttctctgac 60 tcccagcatc ctagactcct catctccatt gtccgtctga tttttggggt ggcagtcaca 120 ggaaattcca tcctggtcct gctgatctgg agtgatgctt gcctccacac ccccatgtac 180 ttcttgttca gccagctctc cctcatggat ctaatgttaa tttccaccac tgtccccaag 240 atggccacta acttcttctc tggacatgag tttatctctc atattggctg tggagtccaa 300 atttttctgt acttgatgct aggagtggct gagtgcgttc ttctcactct catggccttt 360 ttggccatct gtaaccccct cagatatccc ataatcatga ctccccgagt ctgtatgcaa 420 atggccactg gctcatgggc tggaggtgtg cttatctcct taatgcacac aatttatgcc 480 atgcactttt ttacttgctg ctccaggaaa actgaccatt tcttctgtga gataatggcc 540 cttctgaagc tctcttgtga ggacacctcc atctatgaga aagtggtgtt actgtccagc 600 attgctttcc ttctcatccc ttttggactc attctgacat cctacatata catctacctt 660 actgttctcc gcatgaactc tcctgagggc aaaaacaaag ctctagctac ctgttcctcc 720 catctttgtg tggtaagtct ctactttggt ccagccatga ttatctacat gactccaggt 780 tcctctctcc cctcagagat ggatcagcat ctctttgtgt ttgatgtaat cattattccc 840 atgcttaacc ccctcatcta cagcctgagg aacaaggagg tgttgggggc tctgaggaag 900 gctcta 906 <210> 388 <211> 302 <212> PRT <213> Canis familiaris <400> 388

Met Glu Gln Gly Asn Glu Ser Ser Thr Thr Asp Phe Ile Leu Leu Ser 1 5 10 15

Phe Phe Ser Asp Ser Gln His Pro Arg Leu Leu Ile Ser Ile Val Arg 20 25 30

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Leu Ile Phe 35 Gly Val Ala Val Thr Gly Asn Ser Ile Leu Val Leu Leu 40 45 Ile Trp Ser Asp Ala Cys Leu His Thr Pro Met Tyr Phe Leu Phe Ser 50 55 60 Gln Leu Ser Leu Met Asp Leu Met Leu Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Ala Thr Asn Phe Phe Ser Gly His Glu Phe Ile Ser His Ile Gly 85 90 95 Cys Gly Val Gln Ile Phe Leu Tyr Leu Met Leu Gly Val Ala Glu Cys 100 105 110 Val Leu Leu Thr Leu Met Ala Phe Leu Ala Ile Cys Asn Pro Leu Arg 115 120 125 Tyr Pro Ile Ile Met Thr Pro Arg Val Cys Met Gln Met Ala Thr Gly 130 135 140 Ser Trp Ala Gly Gly Val Leu Ile Ser Leu Met His Thr Ile Tyr Ala 145 150 155 160 Met His Phe Phe Thr Cys Cys Ser Arg Lys Thr Asp His Phe Phe Cys 165 170 175 Glu Ile Met Ala Leu Leu Lys Leu Ser Cys Glu Asp Thr Ser Ile Tyr 180 185 190 Glu Lys Val Val Leu Leu Ser Ser Ile Ala Phe Leu Leu Ile Pro Phe 195 200 205 Gly Leu Ile Leu Thr Ser Tyr Ile Tyr Ile Tyr Leu Thr Val Leu Arg 210 215 220 Met Asn Ser Pro Glu Gly Lys Asn Lys Ala Leu Ala Thr Cys Ser Ser 225 230 235 240

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His Leu Cys Val Val 245 Ser Leu Tyr Phe Gly Pro Ala Met Ile Ile Tyr 250 255 Met Thr Pro Gly Ser Ser Leu Pro Ser Glu Met Asp Gln His Leu Phe 260 265 270 Val Phe Asp Val Ile Ile Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser 275 280 285 Leu Arg Asn Lys Glu Val Leu Gly Ala Leu Arg Lys Ala Leu 290 295 300

<210> 389 <211> 462 <212> DNA <213> Canis familiaris <400> 389 ttgctgctca tagccatggc ctttgacagt catagggcca tatgtaagcc tctccaccac 60 ctgaccatca aaaggccatg aatgtgcatt ttgatcttag tggttgcctg gaccattggt 120 ctcattggct cattggcctc cttggcttct gtggtaaact tgcccttctg tagcctttaa 180 tgtattgaca gctttaactg tgacatactg tggttcatca aatttgcctt cacagagact 240 tacaacgtaa gctcattgtc actagttcaa tgggttcaat tccttggttg ctttcttctt 300 gctcatcctc tctcaccttc atcctggcca ctcttcagaa acacccctca ggtggttatc 360 caaagctcct tttactcttt aaggtcacat tattgtgtga ttttatttct ttgcccactg 420 atttttttct atatgtggcc ctctccttca aaacatctgg at 462 <210> 390 <211> 65 <212> PRT <213> Canis familiaris <220>

<221> MOD_RES <222> (65)..(65) <223> Any amino acid <400> 390

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Met 1 Gly Ser Ile Pro 5 Trp Leu 069269_0225_SL.TXT Leu Ser Ser Cys Ser Ser 10 Ser Leu 15 Thr Phe Ile Leu Ala Thr Leu Gln Lys His Pro Ser Gly Gly Tyr Pro Lys 20 25 30 Leu Leu Leu Leu Phe Lys Val Thr Leu Leu Cys Asp Phe Ile Ser Leu 35 40 45 Pro Thr Asp Phe Phe Leu Tyr Val Ala Leu Ser Phe Lys Thr Ser Gly 50 55 60

Xaa <210> 391 <211> 840 <212> DNA <213> Canis familiaris <400> 391

gaaatggaaa attgaactgt ggtcactgca tttatctttc caggatttcc caaaccccct 60 taattacaaa agctattctt cttggtcttc ttgatcattt atctgataac tcttctggga 120 aatgctttca cattaacaga gatcagagtc agtcctgtcc tccacactct acagtattat 180 tagcaatttg agcttcttgg acattggctg cttgtctact accatgctgg taaacttatt 240 ccagaagaag actatgtcat aggagggctg cctttcccag ctgttcctat gacctgtgct 300 gaggaaatct tgttggctac tatgacttat gaacactatg tagccatttg ccactttctt 360 cactgtctgc tgctcatgat tccaagggtc tgtgtgtatt ggttgactgg aacttggctg 420 tatgggctaa agaattctgt gacacattca gtgctagcag tcacattcac tttgtgtgag 480 ctcaaccaga tcagctactt tctccatgat ttcctactgc tcgtggagct ctcctgctta 540 catttctttc aatgaatgtg tgctccatat ggcagcacaa ccattggcct gaacccttgc 600 ctgtttactg caatgtctta aatacttatc atccctacca ggcttaggat gtcctcggga 660 cagaaacaat gcctctatgt ggacattcca ctccactatg gtggtggttt ttttagggac 720 agctgacttc aactatagca acacagtgta ggctacaacc cagaaatgga catccttgtt 780

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069269_0225_SL.TXT tctgtgattt tctgtgttgt gacaccccgc ctccttgtgg aactccatca tctacagtct 840 <210> 392 <211> 62 <212> PRT <213> Canis familiaris <400> 392

Asn Gly Lys 1 Leu Asn 5 Cys Gly His Cys Ile Tyr Leu Ser Arg Ile Ser 10 15 Gln Thr Pro Leu Ile Thr Lys Ala Ile Leu Leu Gly Leu Leu Asp His 20 25 30 Leu Ser Asp Asn Ser Ser Gly Lys Cys Phe His Ile Asn Arg Asp Gln 35 40 45 Ser Gln Ser Cys Pro Pro His Ser Thr Val Leu Leu Ala Ile 50 55 60

<210> 393 <211> 900 <212> DNA <213> Canis familiaris <400> 393

atgacaccat ttgaaatgaa caatcaaaca gatgccactg aattcatctt cttgggattt 60 tccaaccacc ccaaactaca gggcttgttt ttcctggttt tcttgatcat ttacctgaca 120 acactcctgg gaaacatgct cataataaca gccactaaaa tcagccttgc tcttcatact 180 ccaatgtatt atttcctcag caacctgagt ttcttggaca tctgctatac atccaccacc 240 atcccagtca tgctgatgaa cttcttccgc aaaaagaaaa ccatctcata tgaaggctgc 300 ttttctcaga cttttttcct cgtgacatgc actggcactg gatgtgtttt attggttgct 360 atggcttatg accattatgt agtcatttgc cacccccttc aatatccggt cctcatgagt 420 gtgaaggtct gtgttctgtg tgggctggtg aattctgtga tacacaccat gctagcagcc 480 acactcactc tctgtgggcc caaccaaatc agccactttc tctgtgacat cccattgctt 540 ctggagctct cttgctcaga cacctctctc aatgagtctg tgctccatgt ggtcaaggcc 600 atcattgacc tgagcccctg cctgtttacc ggagtgtcct atgtactcat catctctgcc 660

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069269_0225_SL.TXT attcttagga ttccctctgc tcagggcagg aacaaggcct tctctacctg tgtatcccac cttactgttg ttgtgatctt ttatggaaca gccaatttca actatgacag aaccaacatg gggtataacc tggacattgt tatcctggtt tttgtacttt tctgtgttgt gaccttcatg ttgaacccca tcatatacag tctgggaaac aaggaggcca agggtcccct gaggaagcta

720

780

840

900 <210> 394 <211> 300 <212> PRT <213> Canis familiaris <400> 394

Met Thr Pro 1 Phe Glu Met Asn Asn 5 Gln Thr Asp Ala Thr Glu Phe Ile 10 15 Phe Leu Gly Phe Ser Asn His Pro Lys Leu Gln Gly Leu Phe Phe Leu 20 25 30 Val Phe Leu Ile Ile Tyr Leu Thr Thr Leu Leu Gly Asn Met Leu Ile 35 40 45 Ile Thr Ala Thr Lys Ile Ser Leu Ala Leu His Thr Pro Met Tyr Tyr 50 55 60 Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Thr Thr 65 70 75 80 Ile Pro Val Met Leu Met Asn Phe Phe Arg Lys Lys Lys Thr Ile Ser 85 90 95 Tyr Glu Gly Cys Phe Ser Gln Thr Phe Phe Leu Val Thr Cys Thr Gly 100 105 110 Thr Gly Cys Val Leu Leu Val Ala Met Ala Tyr Asp His Tyr Val Val 115 120 125 Ile Cys His Pro Leu Gln Tyr Pro Val Leu Met Ser Val Lys Val Cys 130 135 140

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Val 145 Leu Cys Gly Leu Val 150 Asn 069269_0225_SL.TXT Ser Val Ile His Thr Met 155 Leu Ala Ala 160 Thr Leu Thr Leu Cys Gly Pro Asn Gln Ile Ser His Phe Leu Cys Asp 165 170 175 Ile Pro Leu Leu Leu Glu Leu Ser Cys Ser Asp Thr Ser Leu Asn Glu 180 185 190 Ser Val Leu His Val Val Lys Ala Ile Ile Asp Leu Ser Pro Cys Leu 195 200 205 Phe Thr Gly Val Ser Tyr Val Leu Ile Ile Ser Ala Ile Leu Arg Ile 210 215 220 Pro Ser Ala Gln Gly Arg Asn Lys Ala Phe Ser Thr Cys Val Ser His 225 230 235 240 Leu Thr Val Val Val Ile Phe Tyr Gly Thr Ala Asn Phe Asn Tyr Asp 245 250 255 Arg Thr Asn Met Gly Tyr Asn Leu Asp Ile Val Ile Leu Val Phe Val 260 265 270 Leu Phe Cys Val Val Thr Phe Met Leu Asn Pro Ile Ile Tyr Ser Leu 275 280 285 Gly Asn Lys Glu Ala Lys Gly Pro Leu Arg Lys Leu 290 295 300

<210> 395 <211> 960 <212> DNA <213> Canis familiaris <400> 395 atgacaccat ttgaaatgaa caatcaaaca gatgtcactg aattcatctt cttggggttt tccaaccacc ccaaactaca gggcttgttt ttcctggttt tcttgatcat ttacctgaca acactcctgg gaaacatgct cataataaca gccactaaaa tcagccttgc tcttcatact

120

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ccaatgtatt atttcctcag caacctgagt ttcttggacg tctgctacac atccaccacc 240 atcccagtca tgctggtgaa cttcttccac agaaagaaaa ccatctcata tgaaggctgc 300 ctttcccaga ttttcttcct cgtgacatgc actggcactg aatgtgtctt attggctgct 360 atggcttatg accgctatgt agcaatttgc cacccccttc aatatccggt cctcatgagt 420 gtgaaggtct gtgttttttt ggtgactggg tcctggctat gtgggctggt gaattctgtg 480 atacacacag tgctggcagc cacactcact ctctgtgggc ccaaccaaat cagccacttt 540 ctctgtgaca tcccattgct cctggagctc tcttgctcag acacctctct caatgagtct 600 gtgctccatg tggccagtgc caccattggc ctgagcccct gtctgtttac tggagtgtcc 660 tatatactca taatttctgc cattcttagg attccctctg ctcagggcag gaacaaggcc 720 ttctctacct gtgcatccca ccttactgtt gttgtgatct tttatggaat ggccaatttc 780 aactatgata aacccagaga gggttactcc ttagacatag atattctggt ctctgtgctc 840 ttctgtgttg tgacccccat gttgaacccc atcatataca gtctgagaaa caaggaggtc 900 aagggtgccc tgaggaagtt gactggaggg tatgtgatcc ctggcaatat tagtgtctag 960

<210> 396 <211> 319 <212> PRT <213> Canis familiaris <400> 396

Met Thr Pro Phe Glu Met Asn Asn Gln Thr Asp Val Thr Glu Phe Ile 1 5 10 15 Phe Leu Gly Phe Ser Asn His Pro Lys Leu Gln Gly Leu Phe Phe Leu 20 25 30 Val Phe Leu Ile Ile Tyr Leu Thr Thr Leu Leu Gly Asn Met Leu Ile 35 40 45 Ile Thr Ala Thr Lys Ile Ser Leu Ala Leu His Thr Pro Met Tyr Tyr 50 55 60 Phe Leu Ser Asn Leu Ser Phe Leu Asp Val Cys Tyr Thr Ser Thr Thr 65 70 75 80

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Ile Pro Val Met Leu Val Asn Phe Phe His Arg Lys Lys Thr Ile 95 Ser 85 90 Tyr Glu Gly Cys Leu Ser Gln Ile Phe Phe Leu Val Thr Cys Thr Gly 100 105 110 Thr Glu Cys Val Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Gln Tyr Pro Val Leu Met Ser Val Lys Val Cys 130 135 140 Val Phe Leu Val Thr Gly Ser Trp Leu Cys Gly Leu Val Asn Ser Val 145 150 155 160 Ile His Thr Val Leu Ala Ala Thr Leu Thr Leu Cys Gly Pro Asn Gln 165 170 175 Ile Ser His Phe Leu Cys Asp Ile Pro Leu Leu Leu Glu Leu Ser Cys 180 185 190 Ser Asp Thr Ser Leu Asn Glu Ser Val Leu His Val Ala Ser Ala Thr 195 200 205 Ile Gly Leu Ser Pro Cys Leu Phe Thr Gly Val Ser Tyr Ile Leu Ile 210 215 220 Ile Ser Ala Ile Leu Arg Ile Pro Ser Ala Gln Gly Arg Asn Lys Ala 225 230 235 240 Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Val Ile Phe Tyr Gly 245 250 255 Met Ala Asn Phe Asn Tyr Asp Lys Pro Arg Glu Gly Tyr Ser Leu Asp 260 265 270 Ile Asp Ile Leu Val Ser Val Leu Phe Cys Val Val Thr Pro Met Leu 275 280 285

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Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Leu 290 295 300

Arg Lys Leu Thr Gly Gly Tyr Val Ile Pro Gly Asn Ile Ser Val 305 310 315 <210> 397 <211> 240 <212> DNA <213> Canis familiaris <400> 397 gaaggccaca gaaaggcctt ctccacctgg tcctcccacc tctgtgtggt ggggctcttc tttggcagtg ccactgtcat gtacatggcc ccctaatcca accacccaga ggagcagcgg aagattcttt ccctatttta tagccttttc aatcctatgc tgaacccact gacctacagt ctgaggaaca cagaggtcaa gggtgccctg aggagagcct tatacaggca gaggcatata

120

180

240 <210> 398 <211> 53 <212> PRT <213> Canis familiaris <400> 398

Lys Ala Thr Glu Arg Pro Ser Pro 1 5 Trp Gly Ser Ser Leu Ala Val Pro 20 Pro Thr Thr Gln Arg Ser Ser Gly 35 40 Phe Ser Ile Leu Cys 50

Pro Gly Pro Pro Thr Ser Val Trp 10 15 Leu Ser Cys Thr Trp Pro Pro Asn 25 30 Arg Phe Phe Pro Tyr Phe Ile Ala 45

<210> 399 <211> 936 <212> DNA <213> Canis familiaris <400> 399

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atggaaagtg caaaccattc agtggtgtct gaattcattt tgcttggact ttacaaatct 60 cagaaccttc agattttgtt ctttgtagga ttctctgtgg tctatgccgg gattgtgtta 120 tgaaacctcc ttatcttggt cactgtgacc tttgactcac accttcacac accaatgtac 180 tttctgctta tcaatctgtc ctgtatagat atgatcctag cttcttttgc tacccctaag 240 atgatcatgg acttcctccg aaaacagaag accatctctt ggtggggatg ttattctcag 300 atgtttttca tgcacctcct aggtggaact gagatgatgt tgcttgtagc catggcaata 360 gacaggtatg ttgccatatg caaacccctc cattacatga ccataatgag cccacgagtg 420 cttgttgggc tgctgttatc ttcctatgca gttggctttg tgcactcgtc tagtcaaatg 480 gctttcatgt tgcatttgcc attctgtggt cccagtgtgg tggacagctt tttctgtgac 540 cttccccttg tgatcaaact tgcctgcgag gacacctacc tgctacaact gctggttatt 600 gctgacagtg gcctcctgtc tctgatctgc ttcctcctct tgcttgtctc ctatgtggtt 660 atcatatact cagtcaggca ccgtgctgct ggtggttcag ccaaggcctt ctccactctg 720 tcagcacaca tcacagttat cactctcttc tttgccccat gtgtctttat ctatgtatgg 780 ccctttagca gatattctgt agataaaatt ctttccgtgt tttatacaat tttcacacct 840 ctcttaaatc ctattattta tacattaagg aatcaagaag taaaagcagc cataaagagg 900 ataagaactc gacatataaa ttcaaaacac actttg 936 <210> 400 <211> 254 <212> PRT <213> Canis familiaris <400> 400 Met Tyr Phe Leu Leu Ile Asn Leu Ser Cys Ile Asp Met Ile Leu Ala 1 5 10 15 Ser Phe Ala Thr Pro Lys Met Ile Met Asp Phe Leu Arg Lys Gln Lys 20 25 30 Thr Ile Ser Trp Trp Gly Cys Tyr Ser Gln Met Phe Phe Met His Leu 35 40 45 Leu Gly Gly Thr Glu Met Met Leu Leu Val Ala Met Ala Ile Asp Arg

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50 55 60 Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Ile Met Ser Pro 65 70 75 80 Arg Val Leu Val Gly Leu Leu Leu Ser Ser Tyr Ala Val Gly Phe Val 85 90 95 His Ser Ser Ser Gln Met Ala Phe Met Leu His Leu Pro Phe Cys Gly 100 105 110 Pro Ser Val Val Asp Ser Phe Phe Cys Asp Leu Pro Leu Val Ile Lys 115 120 125 Leu Ala Cys Glu Asp Thr Tyr Leu Leu Gln Leu Leu Val Ile Ala Asp 130 135 140 Ser Gly Leu Leu Ser Leu Ile Cys Phe Leu Leu Leu Leu Val Ser Tyr 145 150 155 160 Val Val Ile Ile Tyr Ser Val Arg His Arg Ala Ala Gly Gly Ser Ala 165 170 175 Lys Ala Phe Ser Thr Leu Ser Ala His Ile Thr Val Ile Thr Leu Phe 180 185 190 Phe Ala Pro Cys Val Phe Ile Tyr Val Trp Pro Phe Ser Arg Tyr Ser 195 200 205 Val Asp Lys Ile Leu Ser Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu 210 215 220 Asn Pro Ile Ile Tyr Thr Leu Arg Asn Gln Glu Val Lys Ala Ala Ile 225 230 235 240 Lys Arg Ile Arg Thr Arg His Ile Asn Ser Lys His Thr Leu

245 250 <210> 401

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069269_0225_SL.TXT <211> 939 <212> DNA <213> Canis familiaris <400> 401

atggagggtg ctaatcaaac tgggatggtt cgcttccact tccgcccctt ctccaaactc 60 cctgaggtgc agatgttgat ttttgtggcc ttcttgatca tgtacctggt cagcatcagc 120 ggcaatgtct ccatttctct catcatctgg ctcaaccgtt ctctgcacac ccccatgtac 180 ttcttcctgg ccaacttggc agctctggag atctgctact cttccaccat cgcccctctg 240 accctggcca gcgtcctgtc cacagagaga gccctcatct ccctgcctgg ctgtggtacc 300 cagatgttct tcttcatctt cctgggcagt gctgactgta ttctactagc tgtcatggcc 360 tatgacaggt ttgtggccat ctgtcaccct ttgcgttaca ccctcatgat gagttggcgg 420 ttgtgtgtgc aactggccat ggggtctctg gtgctggggt tcatcttggc catgcagttg 480 actgtgctca tcttccaact ccccttctgc agcagtaaag aaatcagtct gttctactgt 540 gatgtcctcc ctgtcatgag actggcctgt gcagacacct gggtccatga ggccaccctc 600 tttgtggtca gcatcaccgt cctcactatc cccttcctgc tgatcactct ctcctacgtc 660 ttcatcgtgg ccgccatcct gaagattcgc tcagcagagg ggaggcacaa ggccttctcc 720 acttgctcct ctcacctgac tgtggtcctg ctgcagtatg gatgtgggag cctcatctac 780 ctgtgcccca gctccagtta ctctccagag aggggccagg tggtgtctgt ggtttacaca 840 ttcatcacgc ctgtgctgaa ccccttgatc tacagcatga gaaacaggga gcttaaggat 900 gctttgagga gaaccatgat caggttcctg ttgtcctaa 939

<210> 402 <211> 312 <212> PRT <213> Canis familiaris <400> 402

Met Glu Gly Ala Asn Gln Thr Gly Met Val Arg Phe His Phe Arg Pro 1 5 10 15 Phe Ser Lys Leu Pro Glu Val Gln Met Leu Ile Phe Val Ala Phe Leu 20 25 30

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Ile Met Tyr 35 Leu Val Ser Ile 069269_0225_SL.TXT Ser Gly Asn Val Ser Ile 40 45 Ser Leu Ile Ile Trp Leu Asn Arg Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ala Ala Leu Glu Ile Cys Tyr Ser Ser Thr Ile Ala Pro Leu 65 70 75 80 Thr Leu Ala Ser Val Leu Ser Thr Glu Arg Ala Leu Ile Ser Leu Pro 85 90 95 Gly Cys Gly Thr Gln Met Phe Phe Phe Ile Phe Leu Gly Ser Ala Asp 100 105 110 Cys Ile Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys 115 120 125 His Pro Leu Arg Tyr Thr Leu Met Met Ser Trp Arg Leu Cys Val Gln 130 135 140 Leu Ala Met Gly Ser Leu Val Leu Gly Phe Ile Leu Ala Met Gln Leu 145 150 155 160 Thr Val Leu Ile Phe Gln Leu Pro Phe Cys Ser Ser Lys Glu Ile Ser 165 170 175 Leu Phe Tyr Cys Asp Val Leu Pro Val Met Arg Leu Ala Cys Ala Asp 180 185 190 Thr Trp Val His Glu Ala Thr Leu Phe Val Val Ser Ile Thr Val Leu 195 200 205 Thr Ile Pro Phe Leu Leu Ile Thr Leu Ser Tyr Val Phe Ile Val Ala 210 215 220 Ala Ile Leu Lys Ile Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser 225 230 235 240

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Thr Cys Ser Ser His Leu Thr Val Val Leu 250 Leu Gln Tyr Gly Cys 255 Gly 245 Ser Leu Ile Tyr Leu Cys Pro Ser Ser Ser Tyr Ser Pro Glu Arg Gly 260 265 270 Gln Val Val Ser Val Val Tyr Thr Phe Ile Thr Pro Val Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Met Arg Asn Arg Glu Leu Lys Asp Ala Leu Arg Arg 290 295 300 Thr Met Ile Arg Phe Leu Leu Ser 305 310

<210> 403 <211> 936 <212> DNA <213> Canis familiaris <400> 403

atggccctga gaaatcattc caaggtgtct aaatttattt tttgtggact tacccagtct 60 caagagctga gcttgctctt atttttcttt ctatctgtag tttatgtgac aacagtgtta 120 gcaaatgttg ccatcatggt gactgtgacc tgtgagtccc gacttcatac ccccatgtac 180 ttcctgctcc gcaacctctc ggtcttggac atctgcttct cctccatcac tgctcccaag 240 gtccttgtgg accttctgtc aagaacaaag accatctcct tcaatggttg catcactcag 300 atgttcttct tccaccttct cggtggggca gacatttttt ctctctctgt gatggccttt 360 gaccgctaca tggccatctc caagcccttg cactacgtga ccatcatgag tagggggcga 420 tgcactgccc tcattgtggc ctcctgggtg gggggctttg ttcactccat cgtgcagatt 480 tccctgttgc tgcccctccc cttctgtggg cctaatgttg ttgatggctt ctactgcgat 540 gtcccccagg tcctcaaact tgcctgcact gacacctttg ttcttgaagt cttaatgatt 600 tccaacaatg gtctggtcac taccctgtgg tttgtccttc ttcttgtgtc ctacacagtc 660 atcttgatga tgctgaggtc tcacactggg gaaggcagga ggaaagccat ctctacctgc 720 acagcccaca tcactgtggt gacccttcac tttgtgccct gcatctatgt ctatgcccgg 780

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069269_0225_SL.TXT cccttcactg cccttcccat ggacagagcc gtctccatca ccttcacagt catcatcccg gttctgaacc ccatgatcta caccctgagg aaccaggaga tgaagtcagc catgaggaga ctgaagagaa gacttatgtt ttctgaaagg acatag

840

900

936 <210> 404 <211> 311 <212> PRT <213> Canis familiaris <400> 404

Met Ala 1 Leu Arg Asn His Ser Lys Val Ser Lys Phe Ile Phe Cys Gly 5 10 15 Leu Thr Gln Ser Gln Glu Leu Ser Leu Leu Leu Phe Phe Phe Leu Ser 20 25 30 Val Val Tyr Val Thr Thr Val Leu Ala Asn Val Ala Ile Met Val Thr 35 40 45 Val Thr Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ser Val Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Val Leu Val Asp Leu Leu Ser Arg Thr Lys Thr Ile Ser Phe Asn Gly 85 90 95 Cys Ile Thr Gln Met Phe Phe Phe His Leu Leu Gly Gly Ala Asp Ile 100 105 110 Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Met Ala Ile Ser Lys 115 120 125 Pro Leu His Tyr Val Thr Ile Met Ser Arg Gly Arg Cys Thr Ala Leu 130 135 140 Ile Val Ala Ser Trp Val Gly Gly Phe Val His Ser Ile Val Gln Ile 145 150 155 160

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Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Val Asp Gly 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Val Leu Glu Val Leu Met Ile Ser Asn Asn Gly Leu Val Thr Thr 195 200 205 Leu Trp Phe Val Leu Leu Leu Val Ser Tyr Thr Val Ile Leu Met Met 210 215 220 Leu Arg Ser His Thr Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 225 230 235 240 Thr Ala His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Met Asp Arg Ala Val Ser 260 265 270 Ile Thr Phe Thr Val Ile Ile Pro Val Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Lys Ser Ala Met Arg Arg Leu Lys Arg Arg 290 295 300 Leu Met Phe Ser Glu Arg Thr

305 310 <210> 405 <211> 936 <212> DNA <213> Canis familiaris <400> 405 atgggccaga gcaaccacac caatgtgaag gaatttgtct ttctgaaact cactcacttc cacgagctag aattgttctt gtttgtggtc ttccttgctg tatatgtagc aactgtgctg ggcaatgtcc tcattgtggt gaccatcacc tgtgagtccc acctccactc tcccatgtac Page 450

120

180

069269_0225_SL.TXT

tttctgctgc ggaacaaatc agtcctggac attgtctttt catctgtcac tgttcccaag 240 ttcctggtgg atctgttatc agagagaaaa accatctcct acaatggctg catggcacag 300 atcttcttct tccacttcgc tggtggggca gacattttct tcctctctgt gatggcctat 360 gacaggtacc ttgcaatcgc caaacccctg cattatgtga ccattatgag gagagagacg 420 tgggtgggct tggtggtggc ttcctgggtg ggtggtggtt tgcactcaat tgtccaggta 480 actctcatgc ttccactccc tttctgtggc cccaacatcc tggatgcctt ctactgtgat 540 gtgccccaag tgattaagct ggcctgtacc aacacctttg ccctggagct tctcatgatc 600 tctaacaatg ggctggtgac cctgctgtgg ttcctcctgc tcctgggctc ctacactgtc 660 attctggtga tgctgagatc tcactctggg gaggggcgga ataaggccct gtccacctgc 720 acttcccata tcttcgtggt gaccctgcac ttcgtgcctt gcgtctacat ctactgccgg 780 cccttcatca cgctgcccat ggacacagtt gtatccatca ataacacagt cattaccccc 840 atgctgaacc ccatgatcta tacactgagg aaccaggaga tgaagtcagc catgaaaaga 900 ctgcagagaa ggcttggacc ttctgagagc agttag 936

<210> 406 <211> 311 <212> PRT <213> Canis familiaris <400> 406

Met Gly Gln Ser Asn His Thr Asn Val Lys Glu Phe Val Phe Leu Lys 1 5 10 15 Leu Thr His Phe His Glu Leu Glu Leu Phe Leu Phe Val Val Phe Leu 20 25 30 Ala Val Tyr Val Ala Thr Val Leu Gly Asn Val Leu Ile Val Val Thr 35 40 45 Ile Thr Cys Glu Ser His Leu His Ser Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Lys Ser Val Leu Asp Ile Val Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80

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Phe Leu Val Asp Leu 85 Leu Ser Glu Arg Lys Thr Ile Ser Tyr Asn Gly 90 95 Cys Met Ala Gln Ile Phe Phe Phe His Phe Ala Gly Gly Ala Asp Ile 100 105 110 Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Ala Lys 115 120 125 Pro Leu His Tyr Val Thr Ile Met Arg Arg Glu Thr Trp Val Gly Leu 130 135 140 Val Val Ala Ser Trp Val Gly Gly Gly Leu His Ser Ile Val Gln Val 145 150 155 160 Thr Leu Met Leu Pro Leu Pro Phe Cys Gly Pro Asn Ile Leu Asp Ala 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asn Thr 180 185 190 Phe Ala Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Val Thr Leu 195 200 205 Leu Trp Phe Leu Leu Leu Leu Gly Ser Tyr Thr Val Ile Leu Val Met 210 215 220 Leu Arg Ser His Ser Gly Glu Gly Arg Asn Lys Ala Leu Ser Thr Cys 225 230 235 240 Thr Ser His Ile Phe Val Val Thr Leu His Phe Val Pro Cys Val Tyr 245 250 255 Ile Tyr Cys Arg Pro Phe Ile Thr Leu Pro Met Asp Thr Val Val Ser 260 265 270 Ile Asn Asn Thr Val Ile Thr Pro Met Leu Asn Pro Met Ile Tyr Thr 275 280 285

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Leu Arg Asn Gln Glu Met Lys Ser Ala Met Lys Arg Leu Gln Arg Arg 290 295 300

Leu Gly Pro Ser Glu Ser Ser

305 310 <210> 407 <211> 960 <212> DNA <213> Canis familiaris <400> 407

atgtccacag ttaaggcctg gaacagctct tcagtgacca tgttcatcct cctgggattt 60 gcagaccatc cagaactgca gactcttctc tttgtgacct tcctgagtat ctatcttgtg 120 acactggcct ggaacctggc cctcatcttt ctgatcagaa gtgaccccca tctgcacaca 180 cccatgtact tcttcctcag caacttgtcc ttcattgaca tctgttattc ttccacagtg 240 gcccccaaga tgctcactga tttcttccag gagcaaaaga ccatctcgtt cttgggctgt 300 gctgctcagt tttttttctt tgtcagcatg ggtctcactg agtgcttcct tctgactgcc 360 atggcatatg atcgatacgc agccatctcc aaccccttgc tctacactgc catcatgtcc 420 cagggcctct gtacacgcat ggtgctgggg gcatatgtcg gtggtttcct gagctccttg 480 atccaggcca tctctatatt tcagctccac ttctgtggac ccaatatcat caaccatttc 540 ttctgtgacc ttccaccagt cctggcactt tcttgctctg acaccttccc tagtcaagtg 600 gtgaattttc tcatagtgat cactgttggg ggaacatcat tcctcatcct cctcatctcc 660 tacagttaca taggagctgc tgtcttgaag atccgctcag tggaaggccg aaggaaagcc 720 ttcaacacat gtgcctcgca tctgatggtg gtgactcttc tgtttgggac agctcttttc 780 atgtacctgc ggcccagctc cagctactca cttgccaggg acaaggtggt gtctgtcttc 840 tattcgctgg tgatccccat gctgaaccct ctcatttaca gtctaaggaa cagagatatc 900 aaagacgccc tgtggaaggc attggagaag aagaaagtgt ttttcctaga tcatgattga 960

<210> 408 <211> 319 <212> PRT

Page 453

069269_0225_SL.TXT <213> Canis familiaris <400> 408

Met Ser Thr Val Lys Ala Trp Asn Ser Ser Ser Val Thr Met Phe Ile 1 5 10 15 Leu Leu Gly Phe Ala Asp His Pro Glu Leu Gln Thr Leu Leu Phe Val 20 25 30 Thr Phe Leu Ser Ile Tyr Leu Val Thr Leu Ala Trp Asn Leu Ala Leu 35 40 45 Ile Phe Leu Ile Arg Ser Asp Pro His Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Ser Asn Leu Ser Phe Ile Asp Ile Cys Tyr Ser Ser Thr Val 65 70 75 80 Ala Pro Lys Met Leu Thr Asp Phe Phe Gln Glu Gln Lys Thr Ile Ser 85 90 95 Phe Leu Gly Cys Ala Ala Gln Phe Phe Phe Phe Val Ser Met Gly Leu 100 105 110 Thr Glu Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala 115 120 125 Ile Ser Asn Pro Leu Leu Tyr Thr Ala Ile Met Ser Gln Gly Leu Cys 130 135 140 Thr Arg Met Val Leu Gly Ala Tyr Val Gly Gly Phe Leu Ser Ser Leu 145 150 155 160 Ile Gln Ala Ile Ser Ile Phe Gln Leu His Phe Cys Gly Pro Asn Ile 165 170 175 Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Ala Leu Ser Cys 180 185 190 Ser Asp Thr Phe Pro Ser Gln Val Val Asn Phe Leu Ile Val Ile Thr

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195 069269_0225_SL.TXT 200 205 Val Gly Gly Thr Ser Phe Leu Ile Leu Leu Ile Ser Tyr Ser Tyr Ile 210 215 220 Gly Ala Ala Val Leu Lys Ile Arg Ser Val Glu Gly Arg Arg Lys Ala 225 230 235 240 Phe Asn Thr Cys Ala Ser His Leu Met Val Val Thr Leu Leu Phe Gly 245 250 255 Thr Ala Leu Phe Met Tyr Leu Arg Pro Ser Ser Ser Tyr Ser Leu Ala 260 265 270 Arg Asp Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Asp Ala Leu 290 295 300 Trp Lys Ala Leu Glu Lys Lys Lys Val Phe Phe Leu Asp His Asp 305 310 315

<210> 409 <211> 960 <212> DNA <213> Canis familiaris <400> 409

atggttgcag gaaagaacaa cacaattgtg acgaaattca tcctcctggg attttcagat 60 catcctcaaa tgaagctttt ccttttcatg ttatttctgg ggatttatct cttgacacta 120 gcctggaacc tgagtctcat tgtcctcatc aggatggact gccacctgca cacgcccatg 180 tacttcttcc tcagtaacct atccttccta gatatctgct atgtgtcctc cacaactccc 240 aagatgctct ctgacatcat cacagggcag aaaaccattt cctttgttgg ctgtgccact 300 cagtactttg tgttctgtgg aatggggctg actgaatgct ttcttttggc agccatggca 360 tatgaccgct atgctgcaat ctgcaaccca ttgctctaca cagccctcat ttcccacacc 420 ctttgtttaa agatggtggt tggtgcctat gcaggtggat tcctcagttc tttgattgaa 480

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acatactctg tctacaagca tgatttctgt gggcccaaca tgattgacca cttcttctgt 540 gaccttcctc ccgttctggt tctatcatgc tctgatacct ttaccagcca ggtggtgaac 600 ttcattgtgg gtgttgttgt tggaatggtg tctgtccttg tgatcctcat ctcttatggt 660 tatattgttg ctgctgtcct aaagaccagc tcagctaaag gtaggaccaa agccttcagc 720 acctgtgcct ctcacctgac ttctgtgact cttttctatg gttctggtct ctttatgtac 780 atgcgaccta gttctagcta ctccctaaac cgggacaagg tggtgtccat attctatgct 840 ctggtgatcc ctatggtgaa tcctatcatc tacagtttta ggaataagga gattaaaaat 900 gccatgaaga aagctatgca gaaggatcac gtgctttctc acgggccttt gtttttctga 960

<210> 410 <211> 319 <212> PRT <213> Canis familiaris <400> 410

Met Val Ala Gly Lys Asn Asn Thr Ile Val Thr Lys Phe Ile Leu Leu 1 5 10 15 Gly Phe Ser Asp His Pro Gln Met Lys Leu Phe Leu Phe Met Leu Phe 20 25 30 Leu Gly Ile Tyr Leu Leu Thr Leu Ala Trp Asn Leu Ser Leu Ile Val 35 40 45 Leu Ile Arg Met Asp Cys His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Phe Leu Asp Ile Cys Tyr Val Ser Ser Thr Thr Pro 65 70 75 80 Lys Met Leu Ser Asp Ile Ile Thr Gly Gln Lys Thr Ile Ser Phe Val 85 90 95 Gly Cys Ala Thr Gln Tyr Phe Val Phe Cys Gly Met Gly Leu Thr Glu 100 105 110

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Cys Phe Leu 115 Leu Ala Ala Met 069269_0225_SL.TXT Ala Tyr Asp Arg Tyr Ala 120 125 Ala Ile Cys Asn Pro Leu Leu Tyr Thr Ala Leu Ile Ser His Thr Leu Cys Leu Lys 130 135 140 Met Val Val Gly Ala Tyr Ala Gly Gly Phe Leu Ser Ser Leu Ile Glu 145 150 155 160 Thr Tyr Ser Val Tyr Lys His Asp Phe Cys Gly Pro Asn Met Ile Asp 165 170 175 His Phe Phe Cys Asp Leu Pro Pro Val Leu Val Leu Ser Cys Ser Asp 180 185 190 Thr Phe Thr Ser Gln Val Val Asn Phe Ile Val Gly Val Val Val Gly 195 200 205 Met Val Ser Val Leu Val Ile Leu Ile Ser Tyr Gly Tyr Ile Val Ala 210 215 220 Ala Val Leu Lys Thr Ser Ser Ala Lys Gly Arg Thr Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ser Val Thr Leu Phe Tyr Gly Ser Gly 245 250 255 Leu Phe Met Tyr Met Arg Pro Ser Ser Ser Tyr Ser Leu Asn Arg Asp 260 265 270 Lys Val Val Ser Ile Phe Tyr Ala Leu Val Ile Pro Met Val Asn Pro 275 280 285 Ile Ile Tyr Ser Phe Arg Asn Lys Glu Ile Lys Asn Ala Met Lys Lys 290 295 300 Ala Met Gln Lys Asp His Val Leu Ser His Gly Pro Leu Phe Phe 305 310 315

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069269_0225_SL.TXT <210> 411 <211> 939 <212> DNA <213> Canis familiaris <400> 411

atgactggag gaggcaatac tacagagatc acttatttca tccttttggg attctctgat 60 ttccccagaa tcctagcagt gctctttgct gtattcctgc tgatttacat tttgactctg 120 acttggaacc tgggcctcat catcttaata aggatggact ctcacctcca cacgcccatg 180 tacttcttcc tcagtaatct gtccttcata gatgtctgct atgtgacctc tacagctccc 240 aagatgctct ccaacttttt ccaagagcag caaaccatca cctttgtggg ttgtgccgtt 300 cagtactttg tcttttcaac catgggactg agtgagtctt gtctcatgac agccatggct 360 tatgaccgat acactgccat ttgtaatcca cttctttatt catcagtcat gtcacccacg 420 ctctgtattc agatggtgct gggatcctat ctggctgcac tctctgcttc tatatcccag 480 ttgtgtgcca tgtttcagct tcatttctgt gggcctaatg tcatcaacca cttcttctgt 540 gacatgcccc aactattaat cctgtcctgc actgacacct tccttgtaca actgttgctt 600 gctatactag caatgatctt tgggataata aatgccttta ttattatgat atcttatggc 660 tttattgtca tgtccatcat gaaaatcact tcagctaaag gcagatccaa agctttcaac 720 acctgtgctt ctcatctgac agcagtttct ctcttctata cctcaagtat ctttgtctat 780 ttgagttcca gctctggtgg ttcctccagc tttgacagat ttgcatcagt attctacact 840 gtggttattc ccatgttgaa tcccttgatt tacagtctga ggaacaagga aatcaaagat 900 gccttgaaga ggttacaaaa gaagagatgg tattgctga 939

<210> 412 <211> 312 <212> PRT <213> Canis familiaris <400> 412

Met Thr Gly Gly Gly Asn Thr Thr Glu Ile Thr Tyr Phe Ile Leu Leu

1 5 10 15

Gly Phe Ser Asp Phe Pro Arg Ile Leu Ala Val Leu Phe Ala Val Phe

20 25 30

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Leu Leu Ile 35 Tyr Ile Leu Thr Leu Thr Trp Asn Leu Gly Leu Ile Ile 40 45 Leu Ile Arg Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Phe Ile Asp Val Cys Tyr Val Thr Ser Thr Ala Pro 65 70 75 80 Lys Met Leu Ser Asn Phe Phe Gln Glu Gln Gln Thr Ile Thr Phe Val 85 90 95 Gly Cys Ala Val Gln Tyr Phe Val Phe Ser Thr Met Gly Leu Ser Glu 100 105 110 Ser Cys Leu Met Thr Ala Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Ser Ser Val Met Ser Pro Thr Leu Cys Ile Gln 130 135 140 Met Val Leu Gly Ser Tyr Leu Ala Ala Leu Ser Ala Ser Ile Ser Gln 145 150 155 160 Leu Cys Ala Met Phe Gln Leu His Phe Cys Gly Pro Asn Val Ile Asn 165 170 175 His Phe Phe Cys Asp Met Pro Gln Leu Leu Ile Leu Ser Cys Thr Asp 180 185 190 Thr Phe Leu Val Gln Leu Leu Leu Ala Ile Leu Ala Met Ile Phe Gly 195 200 205 Ile Ile Asn Ala Phe Ile Ile Met Ile Ser Tyr Gly Phe Ile Val Met 210 215 220 Ser Ile Met Lys Ile Thr Ser Ala Lys Gly Arg Ser Lys Ala Phe Asn 225 230 235 240

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Thr Cys Ala Ser His 245 Leu Thr Ala Val Ser Leu Phe Tyr Thr Ser Ser 250 255 Ile Phe Val Tyr Leu Ser Ser Ser Ser Gly Gly Ser Ser Ser Phe Asp 260 265 270 Arg Phe Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Lys Arg 290 295 300 Leu Gln Lys Lys Arg Trp Tyr Cys

305 310 <210> 413 <211> 939 <212> DNA <213> Canis familiaris <400> 413

atgactgggg gaggaaatac tacagagatc acttatttca tccttttggg cttctctgat 60 ttccccagaa tcctagcagt gctctttgct gtattcctgc tgatttacat tttgactctg 120 acttggaacc tgggcctcat catcttaata aggatggact ctcacctcca cacgcccatg 180 tacttcttcc tcagtaatct gtccttcata gatgtctgct atgtgacctc tacagctccc 240 aagatgctct ccaacttttt ccaagagcag caaaccatca cctttgtggg ttgtgccgtt 300 cagtactttg tcttttcaac catgggactg agtgagtctt gtctcatgac agccatggct 360 tatgaccgat acactgccat ttgtaatcca cttctctatt catcagtcat gtcacccaca 420 ctctgtattc agatggtgct gggatcctat ctggctgcac tctctgcttc tatatcccag 480 ttgtgtgcca tgtttcagct tcatttctgt gggctgaatg tcatcaatca cttcttctgt 540 gacatgcccc aactattagt cctgtcctgc actgacactt tgtttgtaaa cctcttgact 600 gctatattaa caatgatctt tgggataata aatgccttta ttattatgat atcttatggc 660 tttattgtca tgtccatcat gaaaatcact tcagctaaag gcagatccaa agctttcaac 720 acctgtgctt ctcatctgac agcagtttct ctcttctata cctcaggtat ctttgtctat 780

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069269_0225_SL.TXT ttgagttcca gctctggtgg ttcctccagc tttgacagat ttgcatcagt attctacact gtggttattc ccatgttgaa ccccttgatt tacagtctga ggaacaagga aataaaagat gccttgaaga ggttaccaaa gaagacatgg tattgttga

840

900

939 <210> 414 <211> 312 <212> PRT <213> Canis familiaris <400> 414

Met Thr 1 Gly Gly Gly Asn Thr Thr Glu Ile Thr Tyr Phe Ile Leu Leu 5 10 15 Gly Phe Ser Asp Phe Pro Arg Ile Leu Ala Val Leu Phe Ala Val Phe 20 25 30 Leu Leu Ile Tyr Ile Leu Thr Leu Thr Trp Asn Leu Gly Leu Ile Ile 35 40 45 Leu Ile Arg Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Phe Ile Asp Val Cys Tyr Val Thr Ser Thr Ala Pro 65 70 75 80 Lys Met Leu Ser Asn Phe Phe Gln Glu Gln Gln Thr Ile Thr Phe Val 85 90 95 Gly Cys Ala Val Gln Tyr Phe Val Phe Ser Thr Met Gly Leu Ser Glu 100 105 110 Ser Cys Leu Met Thr Ala Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Ser Ser Val Met Ser Pro Thr Leu Cys Ile Gln 130 135 140 Met Val Leu Gly Ser Tyr Leu Ala Ala Leu Ser Ala Ser Ile Ser Gln 145 150 155 160

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Leu Cys Ala Met Phe Gln Leu His Phe Cys Gly Leu Asn Val Ile Asn 165 170 175 His Phe Phe Cys Asp Met Pro Gln Leu Leu Val Leu Ser Cys Thr Asp 180 185 190 Thr Leu Phe Val Asn Leu Leu Thr Ala Ile Leu Thr Met Ile Phe Gly 195 200 205 Ile Ile Asn Ala Phe Ile Ile Met Ile Ser Tyr Gly Phe Ile Val Met 210 215 220 Ser Ile Met Lys Ile Thr Ser Ala Lys Gly Arg Ser Lys Ala Phe Asn 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Tyr Thr Ser Gly 245 250 255 Ile Phe Val Tyr Leu Ser Ser Ser Ser Gly Gly Ser Ser Ser Phe Asp 260 265 270 Arg Phe Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Lys Arg 290 295 300 Leu Pro Lys Lys Thr Trp Tyr Cys

305 310 <210> 415 <211> 948 <212> DNA <213> Canis familiaris <400> 415 atgacggaag gaagaaacag cactatagtt accaggttta tcttattgag attctctgaa tttccaagat gtgacgtcac cgtcttttca atattcctag gcatccacct catgacagtg

120

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tcctggagtg tggatctcat caccctgatc aagatggaat cctacctgca cacccccgtg 180 gatttcttta tcaataagct tgccttctta ggcatttgtt acatttcctc cacaagttcc 240 aagatgctct ctgatttctt gaagaagcag aaatccatct cctgtctggg gtggaccacg 300 cagcactcat tctctatcct gggtgtgact gagagctgtt tcctggcagc tatgggttat 360 gaccgatgtg cttccatttg taatcctctg ctctgtactg ccatcatgtc acccaccctc 420 tgtgtgcaga tggtggcagg atcttgtata actggattct cgggctcatt tatccaactg 480 tatgccctac ttcagctcca tttctgtggg ccaaatgtca tcaatcattt cttctgtgat 540 cttccccaac cgccgatcct atcctgctct gacacatttt tctttcaact catgacctct 600 gtgctcacag tgatctttgg actcacatcc ttggttatca tgatatccta tgtcttggtt 660 atcatgatat cctatggtta tattgttgct accattttgg agatcacatc agctgaagca 720 gatccaaggc cttcaacaat catgcttctc actgacagct gtgactcttt tttatggctc 780 cagcaccttt gtctatttgt gccctagttc tgatgatttt ctgagccaaa ataagcttta 840 atctgttgta tatgcttggt gattcctatg ttaaatctat tgatctacag cttaaggagt 900 aaggaaatcg aaaatgcctc aagcagatgg aagaagagaa tattttca 948

<210> 416 <211> 268 <212> PRT <213> Canis familiaris <400> 416

Met 1 Thr Glu Gly Arg Asn Ser Thr Ile Val Thr Arg Phe Ile Leu Leu 5 10 15 Arg Phe Ser Glu Phe Pro Arg Cys Asp Val Thr Val Phe Ser Ile Phe 20 25 30 Leu Gly Ile His Leu Met Thr Val Ser Trp Ser Val Asp Leu Ile Thr 35 40 45 Leu Ile Lys Met Glu Ser Tyr Leu His Thr Pro Val Asp Phe Phe Ile 50 55 60 Asn Lys Leu Ala Phe Leu Gly Ile Cys Tyr Ile Ser Ser Thr Ser Ser

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65 70 75 80 Lys Met Leu Ser Asp Phe Leu Lys Lys Gln Lys Ser Ile Ser Cys Leu 85 90 95 Gly Trp Thr Thr Gln His Ser Phe Ser Ile Leu Gly Val Thr Glu Ser 100 105 110 Cys Phe Leu Ala Ala Met Gly Tyr Asp Arg Cys Ala Ser Ile Cys Asn 115 120 125 Pro Leu Leu Cys Thr Ala Ile Met Ser Pro Thr Leu Cys Val Gln Met 130 135 140 Val Ala Gly Ser Cys Ile Thr Gly Phe Ser Gly Ser Phe Ile Gln Leu 145 150 155 160 Tyr Ala Leu Leu Gln Leu His Phe Cys Gly Pro Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Pro Gln Pro Pro Ile Leu Ser Cys Ser Asp Thr 180 185 190 Phe Phe Phe Gln Leu Met Thr Ser Val Leu Thr Val Ile Phe Gly Leu 195 200 205 Thr Ser Leu Val Ile Met Ile Ser Tyr Val Leu Val Ile Met Ile Ser 210 215 220 Tyr Gly Tyr Ile Val Ala Thr Ile Leu Glu Ile Thr Ser Ala Glu Ala 225 230 235 240 Asp Pro Arg Pro Ser Thr Ile Met Leu Leu Thr Asp Ser Cys Asp Ser 245 250 255 Phe Leu Trp Leu Gln His Leu Cys Leu Phe Val Pro

260 265 <210> 417

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069269_0225_SL.TXT <211> 960 <212> DNA <213> Canis familiaris <400> 417

atggttgcag gaaagaacaa cacaattgtg atgaaattca gcctcctggg attttcacat 60 catcctcaaa tgaagctttt ccttttcgag ttgcttctgg ggatttatct cttgacacta 120 gcctggaacc tgagtttcat tgtcctcatc aggatggact gccacctgca cacgcccatg 180 tacttcttcc tcagtaacct atccttccta gatatctgct atgtgtcctc cacaactccc 240 aagatgctct ctgacatcat cacagggcag aaaaccattt cctttgttgg ctgtgccact 300 cagtactttg tgttctgtgg aatggggctg actgaatgct ttcttttggc agccatggca 360 tatgaccgct atgctgcaat ctgcaacaca ttgctctaca cagccctcat ttcccacacc 420 ctttgtttaa agatggtggt tggtgcctat gcaggtggat tcctcagttt tttgattgaa 480 acatactctg tctacaagca tgatttctgt gggcccaaca tgattgccca cttcttctgt 540 gaccttcctc ccgttctggt tctatcatgc tctgatatct ttaccagcca ggtggtgaac 600 ttcattgtgg gtgttgttgt tggaatggta tctgtccttg tgatcctcat ctcttatggt 660 tatattgttg ctgctgtcct aaagaccagc tcagctaaag gtaggaccaa agccttcagc 720 acctgtgcct ctcacctgac ttctgtgact cttttctatg gttctggtct ctttatgtac 780 atgcgaccta gttctagcta ctccctaaac cgggacaagg tggtgtccat attctatgct 840 ctggtgatcc ctatggtgaa tcctatcatc tacagtttta ggaataagaa gattaaaaat 900 gccatgaaga aagctatgca gaaggatcac gtgctttctc acgggccttt gtttttctga 960

<210> 418 <211> 319 <212> PRT <213> Canis familiaris <400> 418

Met Val Ala Gly Lys Asn Asn Thr Ile Val Met Lys Phe Ser Leu Leu 1 5 10 15

Gly Phe Ser His His Pro Gln Met Lys Leu Phe Leu Phe Glu Leu Leu 20 25 30

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Leu Gly Ile 35 Tyr Leu Leu Thr 069269_0225_SL.TXT Leu Ala Trp Asn Leu Ser 40 45 Phe Ile Val Leu Ile Arg Met Asp Cys His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Phe Leu Asp Ile Cys Tyr Val Ser Ser Thr Thr Pro 65 70 75 80 Lys Met Leu Ser Asp Ile Ile Thr Gly Gln Lys Thr Ile Ser Phe Val 85 90 95 Gly Cys Ala Thr Gln Tyr Phe Val Phe Cys Gly Met Gly Leu Thr Glu 100 105 110 Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys 115 120 125 Asn Thr Leu Leu Tyr Thr Ala Leu Ile Ser His Thr Leu Cys Leu Lys 130 135 140 Met Val Val Gly Ala Tyr Ala Gly Gly Phe Leu Ser Phe Leu Ile Glu 145 150 155 160 Thr Tyr Ser Val Tyr Lys His Asp Phe Cys Gly Pro Asn Met Ile Ala 165 170 175 His Phe Phe Cys Asp Leu Pro Pro Val Leu Val Leu Ser Cys Ser Asp 180 185 190 Ile Phe Thr Ser Gln Val Val Asn Phe Ile Val Gly Val Val Val Gly 195 200 205 Met Val Ser Val Leu Val Ile Leu Ile Ser Tyr Gly Tyr Ile Val Ala 210 215 220 Ala Val Leu Lys Thr Ser Ser Ala Lys Gly Arg Thr Lys Ala Phe Ser 225 230 235 240

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Thr Cys Ala Ser His 245 Leu Thr 069269_0225_SL.TXT Ser Val Thr Leu Phe Tyr 250 Gly Ser 255 Gly Leu Phe Met Tyr Met Arg Pro Ser Ser Ser Tyr Ser Leu Asn Arg Asp 260 265 270 Lys Val Val Ser Ile Phe Tyr Ala Leu Val Ile Pro Met Val Asn Pro 275 280 285 Ile Ile Tyr Ser Phe Arg Asn Lys Lys Ile Lys Asn Ala Met Lys Lys 290 295 300 Ala Met Gln Lys Asp His Val Leu Ser His Gly Pro Leu Phe Phe 305 310 315

<210> 419 <211> 939 <212> DNA <213> Canis familiaris <400> 419

atgactgggg gaggaaatac tacagagatc acttatttca tccttttggg attctctgat 60 ttccccagaa tcctagcagt gctctttgct gtattcctgc tgatttacat tttgactctg 120 acttggaacc tgggcctcat catcttaata aggatggact ctcacctcca cacacccatg 180 tacttcttcc tcagtaatct gtccttcata gatgtctgct atgtgacctc tacagctccc 240 aagatgctct ccaacttttt ccaagagcag caaaccatca cctttgtggg ttgtgccgtt 300 cagtactttg tcttttcaac catgggactg agtgagtctt gtctcatgac agccatggct 360 tatgaccgat acactgccat ttgtaatcca cttctctatt catcagtcat gtcacccacg 420 ctctgtattc agatggtgct gggatcctat ctggctgcac tctctgctag tatatcccag 480 ttgtgtgcca tgtttcagct tcatttctgt gggcctaatg tcatcaatca cttcttctgt 540 gacatgcccc aactattaat cctgtcctgc actgacactt tctttgtaca tctgttgatt 600 gctatactag caacgatctt tgggatgata aatgccttta ttattatgat atcctatggc 660 tatattgtca tgtccatcat gaaaatcact tcagctaaag gcagatccaa agctttcaac 720 acctgtgctt ctcatctgac agcagtttct ctcttctata cctcaagtgt ctttgtttat 780

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069269_0225_SL.TXT ttgagttcca gctctggtgg ttcctccagc tttgacagat ttgcatcagt attctacact gtggttattc ccatgttgaa tcccttgatt tacagtctga ggaacaagga aataaaagat gccttgaaga ggttaccaaa gaagacatgg tattgctga

840

900

939 <210> 420 <211> 312 <212> PRT <213> Canis familiaris <400> 420

Met Thr 1 Gly Gly Gly Asn Thr Thr Glu Ile Thr Tyr Phe Ile Leu Leu 5 10 15 Gly Phe Ser Asp Phe Pro Arg Ile Leu Ala Val Leu Phe Ala Val Phe 20 25 30 Leu Leu Ile Tyr Ile Leu Thr Leu Thr Trp Asn Leu Gly Leu Ile Ile 35 40 45 Leu Ile Arg Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Phe Ile Asp Val Cys Tyr Val Thr Ser Thr Ala Pro 65 70 75 80 Lys Met Leu Ser Asn Phe Phe Gln Glu Gln Gln Thr Ile Thr Phe Val 85 90 95 Gly Cys Ala Val Gln Tyr Phe Val Phe Ser Thr Met Gly Leu Ser Glu 100 105 110 Ser Cys Leu Met Thr Ala Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Ser Ser Val Met Ser Pro Thr Leu Cys Ile Gln 130 135 140 Met Val Leu Gly Ser Tyr Leu Ala Ala Leu Ser Ala Ser Ile Ser Gln 145 150 155 160

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Leu Cys Ala Met Phe Gln Leu His Phe Cys Gly Pro Asn Val Ile Asn 165 170 175 His Phe Phe Cys Asp Met Pro Gln Leu Leu Ile Leu Ser Cys Thr Asp 180 185 190 Thr Phe Phe Val His Leu Leu Ile Ala Ile Leu Ala Thr Ile Phe Gly 195 200 205 Met Ile Asn Ala Phe Ile Ile Met Ile Ser Tyr Gly Tyr Ile Val Met 210 215 220 Ser Ile Met Lys Ile Thr Ser Ala Lys Gly Arg Ser Lys Ala Phe Asn 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Tyr Thr Ser Ser 245 250 255 Val Phe Val Tyr Leu Ser Ser Ser Ser Gly Gly Ser Ser Ser Phe Asp 260 265 270 Arg Phe Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Lys Arg 290 295 300 Leu Pro Lys Lys Thr Trp Tyr Cys 305 310 <210> 421 <211> 939 <212> DNA <213> Canis familiaris <400> 421 atgactggag gaggcaatac tacagagatc acttatttca tccttttggg attctctgat ttccccagaa tcctagcagt gctctttgct gtattcctgc tgatttacat tttgactctg

120 acttggaacc tgggcctcat catcttaata aggatggact cgcacctcca cacgcccatg Page 469

180

069269_0225_SL.TXT tacttcttcc ccagtaatct gtccttcata gatgtctgct atgtgacctc tacagctccc aagatgctct ccaacttttt ccaagagcaa caaaccataa cctttgtggg ttgtgccgtt cagtactttg tcttttcaac catgggactg agtgagtctt gtctcatgac aaccatggct tatgaccgat acactgccat ttgtaatcca cttctctatt catcagtcat gtcacccacg ctctgtattc agatggtgct gggatcctat ctggctgcac tttctgcttc tatatctgag ttgtgtgcct tgtttcagct tcatttctgt gggcttaacg tcatcgacca cttcttctgt gacatgcccc aactgttagt cctatcctgc actgacactt tgtttgtaaa tctcttgact gctatattaa caatgatctt tgggataata aatgccttta ttattgtgat atcctatggc tttattgtca tgtccatcat gaaaatcact tcagctaacg gcagatccaa agctttcaac acctgtgctt ctcatctgac agcagtttct ctcttctata cctcaggtat ctttgtctat ttgagttcca gctctggtgg ttcctccagc tttgacagat ttgcatcagt attctacact gtggttattc ccatgttgaa tcccttgatt tatagtctga ggaacaagga aatcaaagat gccttgaaga ggttacaaaa gaagagatgg tattgctga <210> 422 <211> 312 <212> PRT <213> Canis familiaris

240

300

360

420

480

540

600

660

720

780

840

900

939 <400> 422

Met Thr Gly Gly Gly Asn Thr Thr Glu Ile Thr Tyr Phe Ile Leu Leu 1 5 10 15 Gly Phe Ser Asp Phe Pro Arg Ile Leu Ala Val Leu Phe Ala Val Phe 20 25 30 Leu Leu Ile Tyr Ile Leu Thr Leu Thr Trp Asn Leu Gly Leu Ile Ile 35 40 45 Leu Ile Arg Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Pro 50 55 60 Ser Asn Leu Ser Phe Ile Asp Val Cys Tyr Val Thr Ser Thr Ala Pro 65 70 75 80

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Lys Met Leu Ser Asn 85 Phe Phe Gln Glu Gln Gln Thr Ile Thr Phe Val 90 95 Gly Cys Ala Val Gln Tyr Phe Val Phe Ser Thr Met Gly Leu Ser Glu 100 105 110 Ser Cys Leu Met Thr Thr Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Ser Ser Val Met Ser Pro Thr Leu Cys Ile Gln 130 135 140 Met Val Leu Gly Ser Tyr Leu Ala Ala Leu Ser Ala Ser Ile Ser Glu 145 150 155 160 Leu Cys Ala Leu Phe Gln Leu His Phe Cys Gly Leu Asn Val Ile Asp 165 170 175 His Phe Phe Cys Asp Met Pro Gln Leu Leu Val Leu Ser Cys Thr Asp 180 185 190 Thr Leu Phe Val Asn Leu Leu Thr Ala Ile Leu Thr Met Ile Phe Gly 195 200 205 Ile Ile Asn Ala Phe Ile Ile Val Ile Ser Tyr Gly Phe Ile Val Met 210 215 220 Ser Ile Met Lys Ile Thr Ser Ala Asn Gly Arg Ser Lys Ala Phe Asn 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Tyr Thr Ser Gly 245 250 255 Ile Phe Val Tyr Leu Ser Ser Ser Ser Gly Gly Ser Ser Ser Phe Asp 260 265 270 Arg Phe Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285

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Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Lys Arg 290 295 300

Leu Gln Lys Lys Arg Trp Tyr Cys

305 310 <210> 423 <211> 927 <212> DNA <213> Canis familiaris <400> 423 atgacggaag gaagaaacag cactatagtt accaggttta tcttattgag attctctgaa 60 tttccaagat gtgacgtcat cgtcttttca atattcctag gcatccacct catgacagtg 120 tcctggagtg tggatctcat caccctgatc aagatggaat cctacctgca cacccctgtg 180 gatttcttta tcaataagct tgccttctta ggcatttgtt acgtttcctc cacaagttcc 240 aagatgctct ctgatttctt gaagaagcag aaatccatct cctgtctggg gtggaccacg 300 cagtacttct tctctagcct gggtctgact gagtgctgtc tcctggcagc tatgggttat 360 gaccaatgtg ctaccatttg taatcctctg ctctgtactg ccatcatgtc acccaccctc 420 tgtgtgcaga tggtggcagg atcttgtata actggattct taggctcatt tatccaactg 480 tatgccctac ttcagctcca tttctgtggg ccaaatgtca tcaatcattt cttctgtgat 540 cttccccaac cgccgatcct accctgctct gacacatttt tctttcaact catgacctct 600 gtgctcacag tgatctttgg actcacatct gtcttggtta tcatgatatc ctatggttat 660 attgttgcta ccattttgga gatcacatca gctgaagcag atccaaggcc ttcaacaatc 720 atgcttctca ctgacagctg tgactctttt ttatggctcc agcacctttg tctatttgtg 780 ccctagttct gatgattttc tgagccaaaa taagctttaa tctgttgtat atgcttggtg 840 attcctatgt taaatctatt gatctacagc ttaaggagta aggaaatcga aaatgcctca 900 agcagatgga agaagagaat attttca 927 <210> 424 <211> 261 <212> PRT

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069269_0225_SL.TXT <213> Canis familiaris <400> 424

Met Thr Glu Gly Arg Asn Ser Thr Ile Val Thr Arg Phe Ile Leu Leu 1 5 10 15 Arg Phe Ser Glu Phe Pro Arg Cys Asp Val Ile Val Phe Ser Ile Phe 20 25 30 Leu Gly Ile His Leu Met Thr Val Ser Trp Ser Val Asp Leu Ile Thr 35 40 45 Leu Ile Lys Met Glu Ser Tyr Leu His Thr Pro Val Asp Phe Phe Ile 50 55 60 Asn Lys Leu Ala Phe Leu Gly Ile Cys Tyr Val Ser Ser Thr Ser Ser 65 70 75 80 Lys Met Leu Ser Asp Phe Leu Lys Lys Gln Lys Ser Ile Ser Cys Leu 85 90 95 Gly Trp Thr Thr Gln Tyr Phe Phe Ser Ser Leu Gly Leu Thr Glu Cys 100 105 110 Cys Leu Leu Ala Ala Met Gly Tyr Asp Gln Cys Ala Thr Ile Cys Asn 115 120 125 Pro Leu Leu Cys Thr Ala Ile Met Ser Pro Thr Leu Cys Val Gln Met 130 135 140 Val Ala Gly Ser Cys Ile Thr Gly Phe Leu Gly Ser Phe Ile Gln Leu 145 150 155 160 Tyr Ala Leu Leu Gln Leu His Phe Cys Gly Pro Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Pro Gln Pro Pro Ile Leu Pro Cys Ser Asp Thr 180 185 190 Phe Phe Phe Gln Leu Met Thr Ser Val Leu Thr Val Ile Phe Gly Leu

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195 200 205 Thr Ser 210 Val Leu Val Ile Met 215 Ile Ser Tyr Gly Tyr 220 Ile Val Ala Thr Ile 225 Leu Glu Ile Thr Ser 230 Ala Glu Ala Asp Pro 235 Arg Pro Ser Thr Ile 240 Met Leu Leu Thr Asp 245 Ser Cys Asp Ser Phe 250 Leu Trp Leu Gln His 255 Leu Cys Leu Phe Val 260 Pro

<210> 425 <211> 975 <212> DNA <213> Canis familiaris <400> 425

atggctgggg gaaggaacag tacagcagtt atgaagttca ttctcttggg attctctgaa 60 tttcccaaac tcaccattgt cctttttaca atattcctag ggatctacct catgacagtg 120 tcctggaacc tgggtctcat cactctcatc agggtggatt cccatctgca catacctatg 180 tactttttcc tcagtaactt gtccttcctg gacatctgct atgtttccac tatagcgccc 240 aaaatgctct ctgatttctt caagaaggag aaatccatct cctttctggg atgtaccaca 300 cagtacttct tcttctctag cctgggtctg actgagtgct gtctcctggc agctatgggt 360 tatgaccgat acgctgccat ttgtaatcct ctgctctata ctgccatcat gtcacccacc 420 ctctgtgtgc agatggtggc aggatcttgt acaactggat tcttgggctc atttatccaa 480 ctgtgtgcct tacttcagct ccatttctgt gggccaaatg tcatcaatca tttcttctgt 540 gatcttcccc aactgctgat cctgtcctgc tctgacacat ttttctttca aatcatgacc 600 tctgtgctca cggtgatctt tggactcaca tctgtcttgg ttatcatgat atcctatggt 660 tatattgttg ccaccattct gaagatcaca tcagctgaag gcaggtccaa ggccttcaac 720 acctgtgctt ctcacctgac agcagtgact ctcttctttg gctcaggtat ctttgtttat 780 atgtatccaa actctgatga ttccctgagc caaaacaagt tggcatcagt tttatatact 840

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069269_0225_SL.TXT attataatcc ccatgctaaa tccattgatc tatagcttga ggaacaagga aatcaaagat gccctaaaca gatggaagaa gagaattttt tctgttgtta ctaattatgg aatttatttc agatgtacag catag

900

960

975 <210> 426 <211> 324 <212> PRT <213> Canis familiaris <400> 426

Met Ala 1 Gly Gly Arg Asn Ser Thr Ala Val Met Lys Phe Ile Leu 15 Leu 5 10 Gly Phe Ser Glu Phe Pro Lys Leu Thr Ile Val Leu Phe Thr Ile Phe 20 25 30 Leu Gly Ile Tyr Leu Met Thr Val Ser Trp Asn Leu Gly Leu Ile Thr 35 40 45 Leu Ile Arg Val Asp Ser His Leu His Ile Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Phe Leu Asp Ile Cys Tyr Val Ser Thr Ile Ala Pro 65 70 75 80 Lys Met Leu Ser Asp Phe Phe Lys Lys Glu Lys Ser Ile Ser Phe Leu 85 90 95 Gly Cys Thr Thr Gln Tyr Phe Phe Phe Ser Ser Leu Gly Leu Thr Glu 100 105 110 Cys Cys Leu Leu Ala Ala Met Gly Tyr Asp Arg Tyr Ala Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Thr Ala Ile Met Ser Pro Thr Leu Cys Val Gln 130 135 140 Met Val Ala Gly Ser Cys Thr Thr Gly Phe Leu Gly Ser Phe Ile Gln 145 150 155 160

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Leu Cys Ala Leu Leu Gln Leu His Phe Cys Gly Pro Asn Val Ile Asn 165 170 175 His Phe Phe Cys Asp Leu Pro Gln Leu Leu Ile Leu Ser Cys Ser Asp 180 185 190 Thr Phe Phe Phe Gln Ile Met Thr Ser Val Leu Thr Val Ile Phe Gly 195 200 205 Leu Thr Ser Val Leu Val Ile Met Ile Ser Tyr Gly Tyr Ile Val Ala 210 215 220 Thr Ile Leu Lys Ile Thr Ser Ala Glu Gly Arg Ser Lys Ala Phe Asn 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Val Thr Leu Phe Phe Gly Ser Gly 245 250 255 Ile Phe Val Tyr Met Tyr Pro Asn Ser Asp Asp Ser Leu Ser Gln Asn 260 265 270 Lys Leu Ala Ser Val Leu Tyr Thr Ile Ile Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Asn Arg 290 295 300 Trp Lys Lys Arg Ile Phe Ser Val Val Thr Asn Tyr Gly Ile Tyr Phe 305 310 315 320

Arg Cys Thr Ala <210> 427 <211> 957 <212> DNA <213> Canis familiaris <400> 427

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069269_0225_SL.TXT atggctggag gaaggaacaa tacaatagtc atcagattca tccttttggg attctcagat 60 tatcccaagc ttaagattct tctctttgca ggattcttgg gttcttatgt cttgacagtg 120 gcctggaacc tggggctcat catcttgatt aagatagacc cttatctaca tacacccatg 180 tacttcttcc tcagcaactt atccttctta gatttttgct atgttacctc cacaaccccg 240 aaaatgctct cagacttctt ccagaagcct aaatccatct cttttctggg atgcactatg 300 cagtacttct tcttctctag cctgggtctg actgagtgct gtctcctggc agccatggct 360 tatgatcgat atgctgctat ttgtaatcct ctgctctaca ctactaccat gtcaccccca 420 ttctgtgtac agatgatggt tggagcctat ataactggtc tctttggttc attgatccaa 480 ctgtgtgctt tacttcagct caatttctgt gggccaaatg ttatcaacca tttcttctgt 540 gacctgcctc aattattagt cctatcctgc tctgaaacct tcttcctaaa agtcatgaag 600 tttgtgatag cagtgatttt tggtgtgata tctgtctttg tcatcatgat atcttatggt 660 tatattgttg caaccattct gaagataagc tctgttgaag gcaggtccaa ggctttcaac 720 acctgtactt ctcacttgac agcagtgatc tgtttttttg gatcaggact ctttgtctat 780 atgcacccca gcactggcaa ttctgtgggc caggacaaga tagcatcagt cttctataca 840 gtggtgatcc cgatgttgaa tcctctaatt tacagtctga ggaacaagga aatcaaagat 900 gcccttaaga ggtgtaagaa gagagtcatt ttcccattgt tacagctaaa ggtctag 957 <210> 428 <211> 318 <212> PRT <213> Canis familiaris <400> 428

Met Ala Gly Gly Arg Asn Asn Thr Ile Val Ile Arg Phe Ile Leu Leu 1 5 10 15 Gly Phe Ser Asp Tyr Pro Lys Leu Lys Ile Leu Leu Phe Ala Gly Phe 20 25 30 Leu Gly Ser Tyr Val Leu Thr Val Ala Trp Asn Leu Gly Leu Ile Ile

35 40 45

Leu Ile Lys

Ile Asp Pro Tyr Leu

His

Thr Pro Met

Tyr Phe Phe Leu

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50 55 60

Ser 65 Asn Leu Ser Phe Leu Asp Phe 70 Cys Tyr Val Thr Ser Thr Thr Pro 75 80 Lys Met Leu Ser Asp Phe Phe Gln Lys Pro Lys Ser Ile Ser Phe Leu 85 90 95 Gly Cys Thr Met Gln Tyr Phe Phe Phe Ser Ser Leu Gly Leu Thr Glu 100 105 110 Cys Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Thr Thr Thr Met Ser Pro Pro Phe Cys Val Gln 130 135 140 Met Met Val Gly Ala Tyr Ile Thr Gly Leu Phe Gly Ser Leu Ile Gln 145 150 155 160 Leu Cys Ala Leu Leu Gln Leu Asn Phe Cys Gly Pro Asn Val Ile Asn 165 170 175 His Phe Phe Cys Asp Leu Pro Gln Leu Leu Val Leu Ser Cys Ser Glu 180 185 190 Thr Phe Phe Leu Lys Val Met Lys Phe Val Ile Ala Val Ile Phe Gly 195 200 205 Val Ile Ser Val Phe Val Ile Met Ile Ser Tyr Gly Tyr Ile Val Ala 210 215 220 Thr Ile Leu Lys Ile Ser Ser Val Glu Gly Arg Ser Lys Ala Phe Asn 225 230 235 240 Thr Cys Thr Ser His Leu Thr Ala Val Ile Cys Phe Phe Gly Ser Gly 245 250 255 Leu Phe Val Tyr Met His Pro Ser Thr Gly Asn Ser Val Gly Gln Asp

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260

069269_0225_SL.TXT 265 270

Lys Ile Ala 275 Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Lys Arg 290 295 300 Cys Lys Lys Arg Val Ile Phe Pro Leu Leu Gln Leu Lys Val 305 310 315

<210> 429 <211> 963 <212> DNA <213> Canis familiaris <400> 429

atggccgtgc gaaggaacat cagcatgaca gccaatttca tccttgtggg attttcagag 60 catccagagc tacaagttgt cctctttgtg ttgtttctgg ggatctactc catgactctg 120 gcttggaacc tgggcctcat tgtcttgatc aggatggaat catgtctcca ttcccccatg 180 tatttcttcc ttggaaattt gtcttttgtt gatatctcat atacatcctc cattgccccc 240 aagatgctct gtgacttctt caagcagcag aagaccatct cctttgtggg ctgtgctgct 300 caatttttct tcttcattgg gatgggaggc actgaatgct gtcttctggc agccatggca 360 tatgaccgat atgcggctat ctccaaccct ctgctctaca cagccctcat gtcgcccacc 420 atctgtgtga ggatggtcat tacagcatac actggagggt tcctcactgg attggtccaa 480 accagctctg tattccagct gcatttctgt gggccacgag tcattgatca ctttttctgt 540 gacctgccac ctctgctggt cttatcttgc tctagtacct tcctcagcca ggtagtgaac 600 tttcttgttg tgtgtgcagt tggtgggaca tcagctcttg ttgtcctggt gtcctatggc 660 tacatcattg ctgctgtcat gaagatccat tcaacccaag ggcggatgaa ggctttcaac 720 acctgtgcct ctcatctgac catggtgatt ctcttctatg gctctggtct cttctcatac 780 cttcattcta gtgctagcta ctcacaggac caagacaagg tggtgtccat gttctatgga 840 gctgtgattc ccatgctgaa tcctatcata tatagtttgc gaaacaagga catcaaagat 900 gcattgaaaa aactcaagga caggaagaag cagatatcct ctctgtgtct tatagttcct 960

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069269_0225_SL.TXT tga

963 <210> 430 <211> 320 <212> PRT <213> Canis familiaris <400> 430

Met 1 Ala Val Arg Arg 5 Asn Ile Ser Met Thr Ala Asn Phe Ile Leu Val 10 15 Gly Phe Ser Glu His Pro Glu Leu Gln Val Val Leu Phe Val Leu Phe 20 25 30 Leu Gly Ile Tyr Ser Met Thr Leu Ala Trp Asn Leu Gly Leu Ile Val 35 40 45 Leu Ile Arg Met Glu Ser Cys Leu His Ser Pro Met Tyr Phe Phe Leu 50 55 60 Gly Asn Leu Ser Phe Val Asp Ile Ser Tyr Thr Ser Ser Ile Ala Pro 65 70 75 80 Lys Met Leu Cys Asp Phe Phe Lys Gln Gln Lys Thr Ile Ser Phe Val 85 90 95 Gly Cys Ala Ala Gln Phe Phe Phe Phe Ile Gly Met Gly Gly Thr Glu 100 105 110 Cys Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Ser 115 120 125 Asn Pro Leu Leu Tyr Thr Ala Leu Met Ser Pro Thr Ile Cys Val Arg 130 135 140 Met Val Ile Thr Ala Tyr Thr Gly Gly Phe Leu Thr Gly Leu Val Gln 145 150 155 160 Thr Ser Ser Val Phe Gln Leu His Phe Cys Gly Pro Arg Val Ile Asp 165 170 175

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His Phe Phe Cys Asp Leu Pro Pro Leu Leu Val Leu Ser Cys Ser Ser 180 185 190 Thr Phe Leu Ser Gln Val Val Asn Phe Leu Val Val Cys Ala Val Gly 195 200 205 Gly Thr Ser Ala Leu Val Val Leu Val Ser Tyr Gly Tyr Ile Ile Ala 210 215 220 Ala Val Met Lys Ile His Ser Thr Gln Gly Arg Met Lys Ala Phe Asn 225 230 235 240 Thr Cys Ala Ser His Leu Thr Met Val Ile Leu Phe Tyr Gly Ser Gly 245 250 255 Leu Phe Ser Tyr Leu His Ser Ser Ala Ser Tyr Ser Gln Asp Gln Asp 260 265 270 Lys Val Val Ser Met Phe Tyr Gly Ala Val Ile Pro Met Leu Asn Pro 275 280 285 Ile Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Asp Ala Leu Lys Lys 290 295 300 Leu Lys Asp Arg Lys Lys Gln Ile Ser Ser Leu Cys Leu Ile Val Pro 305 310 315 320

<210> 431 <211> 951 <212> DNA <213> Canis <400> 431 atggagaata cttcaggtcc gggggcatga ctcagtaacc familiaris gcacagaagc ccctcctcct tggtgatcat tctccttcgt cacagagttc ggtatttttg ccacttagac agacctgggt atcctcttgg ttcatctacc ccccacttcc tactcctcag gattaacaga tcatcactct acactcccat ctgtagcccc tgaccccaat ggttgggaat gtatttcttt aaaggcagtg

120

180

240

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069269_0225_S L.TXT gctgccctgc agtcagggaa caaagtcatc tcctacagtg gatgtgctgc ccagttcttt 300 ttctttgtgg gttttgccac tgctgagtgc tacctcctgg cctgcatggc ctatgaccgc 360 catgcagcca tatgcaggcc tcttcattac accaccacca tgagagcagg tgtatgtgcc 420 ctcctgactg ttggctccta tgtctgtggc ttcctcaatg cttctattca cacaggaaac 480 acctttagac tctcgttctg tgcttctcat gagattaatc attttttctg cgatcttcct 540 ccactcttgg ctctctcatg ttccaacaca cgcatcaaca acttggttgt cttctgtgtc 600 gtgggcttca acgtcttttt caccctcctg gtcatcctca tctcttacct cttcatatac 660 atcgccattc aaaggatacg ttctgtggaa ggacgaaaga aagccttctc cacctgtgcc 720 tcccacctca ctgccgtaac catcttctac ggaactatca tcttcatgta cttccagccc 780 agctccagcc agtccatgga cacagacaaa attgattctg tgttttactc agtggtgatt 840 cccatgttga accccttgat ctacagcctt aggaacaaag acgtaaaaaa tgctctccgg 900 aaagtactca acaaacttca cccccagtct gtaagtgtag gtgggaagta g 951 <210> 432 <211> 316 <212> PRT <213> Canis familiaris <400> 432 Met Glu Asn Ser Thr Glu Ala Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asp Asp Pro Asn Leu Gln Val Pro Leu Leu Leu Val Phe Leu Phe Ile 20 25 30 Tyr Leu Ile Thr Leu Val Gly Asn Gly Gly Met Met Val Ile Ile His 35 40 45 Leu Asp Pro His Phe His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Phe Val Asp Leu Gly Tyr Ser Ser Ala Val Ala Pro Lys Ala Val 65 70 75 80 Ala Ala Leu Gln Ser Gly Asn Lys Val Ile Ser Tyr Ser Gly Cys Ala

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85 90 95

Ala Gln Phe Phe Phe Phe Val Gly Phe Ala Thr Ala Glu Cys Tyr Leu 100 105 110 Leu Ala Cys Met Ala Tyr Asp Arg His Ala Ala Ile Cys Arg Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Arg Ala Gly Val Cys Ala Leu Leu Thr Val 130 135 140 Gly Ser Tyr Val Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asn 145 150 155 160 Thr Phe Arg Leu Ser Phe Cys Ala Ser His Glu Ile Asn His Phe Phe 165 170 175 Cys Asp Leu Pro Pro Leu Leu Ala Leu Ser Cys Ser Asn Thr Arg Ile 180 185 190 Asn Asn Leu Val Val Phe Cys Val Val Gly Phe Asn Val Phe Phe Thr 195 200 205 Leu Leu Val Ile Leu Ile Ser Tyr Leu Phe Ile Tyr Ile Ala Ile Gln 210 215 220 Arg Ile Arg Ser Val Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Ile Ile Phe Met 245 250 255 Tyr Phe Gln Pro Ser Ser Ser Gln Ser Met Asp Thr Asp Lys Ile Asp 260 265 270 Ser Val Phe Tyr Ser Val Val Ile Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Arg Lys Val Leu Asn

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069269_0225_SL.TXT 290 295 300

Lys Leu His Pro Gln Ser Val Ser Val Gly Gly Lys 305 310 315

<210> 433 <211> 945 <212> DNA <213> Canis familiaris <400> 433

atggagaacg gtacagaggt gactgagttc attcttgtgg gcttaaccaa tgaccccaaa 60 ctgcagattc ctctcttctt agtcttctcc ctcatttacc tcatcactct ggctgggaac 120 ctgggcatga tggtactgat tctcatggac tcccgtctcc acaatcctat gtactttttc 180 ctcagtaacc tgtctctggt ggactttggt tactctacag ctgtcactcc caaggtcatg 240 gctggattac ttacaggaga caaggtcatg tcctacaatg catgtgtcac ccagttcttt 300 ttctttgtag cctttatcac tgcagaaagt ttcctcttgg cctcaatggc ctatgaccgc 360 tacgcagctg tgtgcaaacc cctgcattat accaccatca tgacaacagg tgtgtgtgct 420 cgtctggtca taggctgtta catctgtggt ttcctgaatg cttccattca cactgggaat 480 attttcagcc tttccttttg tagagccaat gttgttgatc acttcttctg cgatgctcct 540 cctctcctgg ctctctcatg ctcagacaac tacattagtg agatggttat ttttttggtg 600 gtgggcctca atgacttctt ttctgtctta gtcatcctga tatcctacct gtttatattt 660 atcactattc tgaggatgca tgcatctgaa ggacgccaga aggccttttc cacctgtgcc 720 tctcacctca ctgctgtgtc catcttctat gggacaggca ccttcatgta cttacagcca 780 agctccagcc attccatgga cacagacaaa atggcatcca tgttctatac aatggtcatt 840 cccatgctaa acccagtggt ctacagcatg aggaacaaag aggtcaccag tgcctttaaa 900 aagactgtag agaaggcaaa gtcttttata ggattcatat tttaa 945

<210> 434 <211> 314 <212> PRT <213> Canis familiaris <400> 434

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Met 1 Glu Asn Gly Thr 5 Glu Val Thr Glu Phe Ile Leu Val Gly Leu Thr 10 15 Asn Asp Pro Lys Leu Gln Ile Pro Leu Phe Leu Val Phe Ser Leu Ile 20 25 30 Tyr Leu Ile Thr Leu Ala Gly Asn Leu Gly Met Met Val Leu Ile Leu 35 40 45 Met Asp Ser Arg Leu His Asn Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Gly Tyr Ser Thr Ala Val Thr Pro Lys Val Met 65 70 75 80 Ala Gly Leu Leu Thr Gly Asp Lys Val Met Ser Tyr Asn Ala Cys Val 85 90 95 Thr Gln Phe Phe Phe Phe Val Ala Phe Ile Thr Ala Glu Ser Phe Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Thr Thr Gly Val Cys Ala Arg Leu Val Ile 130 135 140 Gly Cys Tyr Ile Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asn 145 150 155 160 Ile Phe Ser Leu Ser Phe Cys Arg Ala Asn Val Val Asp His Phe Phe 165 170 175 Cys Asp Ala Pro Pro Leu Leu Ala Leu Ser Cys Ser Asp Asn Tyr Ile 180 185 190 Ser Glu Met Val Ile Phe Leu Val Val Gly Leu Asn Asp Phe Phe Ser 195 200 205

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Val Leu 210 Val Ile Leu Ile Ser 215 069269_0225_SL.TXT Tyr Leu Phe Ile Phe Ile 220 Thr Ile Leu Arg Met His Ala Ser Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Ala Val Ser Ile Phe Tyr Gly Thr Gly Thr Phe Met 245 250 255 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala 260 265 270 Ser Met Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Val Val Tyr 275 280 285 Ser Met Arg Asn Lys Glu Val Thr Ser Ala Phe Lys Lys Thr Val Glu 290 295 300 Lys Ala Lys Ser Phe Ile Gly Phe Ile Phe 305 310

<210> 435 <211> 789 <212> DNA <213> Canis familiaris <400> 435 aacagcatgg aagtgactgt gttcatcctt ctaggatatt cagatgctcc aggactgcag 60 gcctcactcc ttatgacatt caccttcttc taccttttta ctctagttgg aaatctgggg 120 gtgattgtgt tgattctgtt ggactccagt ctctagatgc ccatgtactt tttcttcagt 180 aacctgtcta tgatggattt ttgttatata cccagggtca tgacaggact tcttagagga 240 gaccaggtca tctcctataa tgcatgtgct gctcagatgt tcttttttgc agcctttgca 300 tctatggaaa gttacctctt agtctcagtg gcctatgact gctactcagc agtgtgcaaa 360 cctctccatt acaccaccac catgacaaca gatgtgtgtg ctcatctggc catttgtgat 420 gttctgaatg cctctgtaag tgttgaagat accttcaatc tttcttcttg tatgtcaaat 480 gtggttcatc actttttctg taatattcca gcagtcacag ctctggcttg ctctgatcag 540

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069269_0225_SL.TXT tgagttggtt atctatatga cctgacttcc tttttaaatg ttttctcttg tagttatctt 600 tatttctacc tgtttacatt tatcaccatc ttgaagatgc actcaactca gaggaatcaa 660 aaggttttgt ccgcctgtgc ttgcaatctc actgtagtct ccatcttcta cgggacagtc 720 atcttcatgt acttgtagcc cagcttcaag aattccatgg acacaatcaa aatggcattt 780 attatattc 789 <210> 436 <211> 59 <212> PRT <213> Canis familiaris <400> 436

Gln His Gly Ser Asp Cys Val His Pro Ser Arg Ile Phe Arg Cys Ser 1 5 10 15 Arg Thr Ala Gly Leu Thr Pro Tyr Asp Ile His Leu Leu Leu Pro Phe 20 25 30 Tyr Ser Ser Trp Lys Ser Gly Gly Asp Cys Val Asp Ser Val Gly Leu 35 40 45 Gln Ser Leu Asp Ala His Val Leu Phe Leu Gln 50 55

<210> 437 <211> 939 <212> DNA <213> Canis familiaris <400> 437

atggagaaca gcactgaggt gaatgagttt atgctcttgg ggctaactga caacccagaa 60 ctgcaagtcc ctctctttat aacattcact ctcatttatt tcactactct cattggaaat 120 ctcggaatta tcatgttgat tctgttggac tctcgtctcc atactcccat gtatatcttc 180 ctcagtaacc tgtctctggt ggactgtgtt tactcctcgg ctgttactcc caaggtgatg 240 gctgggcttc tcacagggga taaagtcatc tcctatggtg gatgtgttgc tcagatgttt 300 ttctttgtgg cttttgccag tgtagactgt ttcctgctcg ctgtcatggc ttatgatcgg 360 catgcagcag tatgtaagcc cttacattat gccaccacta tgaccaccag cttgtgtgct 420

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cagatggcag taggctgcta tgtctggggc tttattgaat cttccatcca cactggattc 480 accttttgcc tctccttctg tcattccaat gtggtccatc actttttctg tgatattccc 540 ccaattatag ctctttcctg ctctgatatc tacctaaatg agattgtgct ctttatctta 600 gcagctttca atgtctgttt tgctcttata gttatcttga cctcctatct gttcatcttc 660 attgccatcc tgaggatgcg ctcagctgag ggaaggaaga aagccttctc cacctgtgcc 720 tcacacctca ctgctgtaac catcttctat ggaactgtca tgttcatgta cttacaacct 780 agttctagtc attctatgga caatgaccaa atggcatctg tgttctatac cataatagtc 840 cccatgttga accctattgt ctacagtcta aggaataaag aggtgaataa tgcttttagg 900 aaagtcacca agaagctaaa gattctgttt ggcccatag 939

<210> 438 <211> 312 <212> PRT <213> Canis familiaris <400> 438

Met Glu Asn Ser Thr Glu Val Asn Glu Phe Met Leu Leu Gly Leu 15 Thr 1 5 10 Asp Asn Pro Glu Leu Gln Val Pro Leu Phe Ile Thr Phe Thr Leu Ile 20 25 30 Tyr Phe Thr Thr Leu Ile Gly Asn Leu Gly Ile Ile Met Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Ile Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Cys Val Tyr Ser Ser Ala Val Thr Pro Lys Val Met 65 70 75 80 Ala Gly Leu Leu Thr Gly Asp Lys Val Ile Ser Tyr Gly Gly Cys Val 85 90 95 Ala Gln Met Phe Phe Phe Val Ala Phe Ala Ser Val Asp Cys Phe Leu 100 105 110

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Leu Ala Val 115 Met Ala Tyr Asp Arg His Ala Ala Val Cys Lys Pro Leu 120 125 His Tyr Ala Thr Thr Met Thr Thr Ser Leu Cys Ala Gln Met Ala Val 130 135 140 Gly Cys Tyr Val Trp Gly Phe Ile Glu Ser Ser Ile His Thr Gly Phe 145 150 155 160 Thr Phe Cys Leu Ser Phe Cys His Ser Asn Val Val His His Phe Phe 165 170 175 Cys Asp Ile Pro Pro Ile Ile Ala Leu Ser Cys Ser Asp Ile Tyr Leu 180 185 190 Asn Glu Ile Val Leu Phe Ile Leu Ala Ala Phe Asn Val Cys Phe Ala 195 200 205 Leu Ile Val Ile Leu Thr Ser Tyr Leu Phe Ile Phe Ile Ala Ile Leu 210 215 220 Arg Met Arg Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Val Met Phe Met 245 250 255 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Asn Asp Gln Met Ala 260 265 270 Ser Val Phe Tyr Thr Ile Ile Val Pro Met Leu Asn Pro Ile Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Asn Asn Ala Phe Arg Lys Val Thr Lys 290 295 300 Lys Leu Lys Ile Leu Phe Gly Pro

305 310

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069269_0225_SL.TXT <210> 439 <211> 702 <212> DNA <213> Canis familiaris <400> 439

ttctgttact cctcaacagt cactcctaag gtcatagctc agctccttat gggagataag 60 gtcatctcta caatgcatgt gttgtcagat gttccttttt ggaatctttg ccactgtgga 120 aagttacctt ttagcctcag tggtctatga ctgctacaca gcagtgtgta aacaccattg 180 caccaccgcc atggaaacag gtgtgtgtgc ttgtctgatc aataggttgc tatgtctgta 240 gttttctgat tgattctttt gatgtaggag acacattcca tttcccttct gtaagtcctc 300 tctcctatcc atcactttct gagctattcc tgcagtatgg ctctctctct cgttctgata 360 gacatgtcag tgagctggtt cttgtctttg tagcaatctt taacatcttt cttgctctcc 420 tagttatctt gatttcctac ttgctcatat ttatcaccat cctggagatg ccctcaattg 480 aggactgtat ccacctgtgc ctctcacctc acttcagtgt ccatcttcta tagggcagtc 540 atcttcatgt acatacagcc cacctccagc cactctatgg gcacagacaa aatcgcatct 600 gtgttctatc ctatgatcat cctcatgctg aacccgctgg tctatagcct gaggaacaaa 660 gaggtcaaga atgctttcaa gaaagttgtt gaggaggtaa aa 702

<210> 440 <211> 62 <212> PRT <213> Canis familiaris <400> 440

Phe 1 Tyr Leu Leu Asn Asn Phe Leu Glu Ser Ile Leu Asp Leu Phe Val 5 10 15 Pro Gln Ala Ile Asp Gln Arg Val Gln His Glu Asp Asp His Arg Ile 20 25 30 Glu His Arg Cys Asp Phe Val Cys Ala His Arg Val Ala Gly Gly Gly 35 40 45 Leu Tyr Val His Glu Asp Asp Cys Pro Ile Glu Asp Gly His

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50 55 60 <210> 441 <211> 864 <212> DNA <213> Canis familiaris <400> 441

cctctctttc taatgtttac cctcatgtac ctcatcattg tggttgggaa cctggggatg 60 accatgctga tcctgctgga ctcccgtctg tatattccca tgtacctctt cctcagtaac 120 ctgtctccgg tggactttcg ttactcctcc acaatcactc ccaaggtaat ggctggatta 180 cttataggag accaggtctt ctcctgcagt gcatgtgctg cccagatgtt cttttttgta 240 ctctttgtgg cagtggaaag ttacctctta gcttcaatgg cctatgaact ctatgcagct 300 gtaatggcct tgcattacac caccaccatg gcgacagtgt gtgtgtgtgc tcatctggcc 360 atagactctt atgcctttgc ctttctaact cctgttattg acattggaga cacgttctat 420 ttctctttct gtatgttcaa ggtagtccat cactttttct gtgatatccc agcagctatg 480 actctaactt gctcagatag agatattaac aagctgattc ttgttatttc aagctttaat 540 atcttttctg cactttttat cttgatttcc tacgtgttca tatttatcac tgttttgaag 600 atacaatcag gtgagggata ccagaagtct ttatctacct gtgcttctca ccttgtcaca 660 gtttccttat tttatgggac agtcatcatc atgtacttac agccaagttc tcatcattcc 720 atggacacag acaaaatcgc atctgtgttc tatactatgg tcacccccat gctgaaccaa 780 gtggtataca gcttgaggaa caaagagatc aagaatgctt tcaagaaggt ggttgaaaag 840 gtaaaatatt ctctaggtat agtt 864

<210> 442 <211> 288 <212> PRT <213> Canis familiaris <400> 442

Pro Leu Phe Leu Met Phe Thr Leu Met Tyr Leu Ile Ile Val Val Gly 1 5 10 15

Asn Leu Gly Met Thr Met Leu Ile Leu Leu Asp Ser Arg Leu Tyr Ile 20 25 30

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Pro Met Tyr 35 Leu Phe Leu Ser Asn Leu Ser Pro Val Asp Phe Arg Tyr 40 45 Ser Ser Thr Ile Thr Pro Lys Val Met Ala Gly Leu Leu Ile Gly Asp 50 55 60 Gln Val Phe Ser Cys Ser Ala Cys Ala Ala Gln Met Phe Phe Phe Val 65 70 75 80 Leu Phe Val Ala Val Glu Ser Tyr Leu Leu Ala Ser Met Ala Tyr Glu 85 90 95 Leu Tyr Ala Ala Val Met Ala Leu His Tyr Thr Thr Thr Met Ala Thr 100 105 110 Val Cys Val Cys Ala His Leu Ala Ile Asp Ser Tyr Ala Phe Ala Phe 115 120 125 Leu Thr Pro Val Ile Asp Ile Gly Asp Thr Phe Tyr Phe Ser Phe Cys 130 135 140 Met Phe Lys Val Val His His Phe Phe Cys Asp Ile Pro Ala Ala Met 145 150 155 160 Thr Leu Thr Cys Ser Asp Arg Asp Ile Asn Lys Leu Ile Leu Val Ile 165 170 175 Ser Ser Phe Asn Ile Phe Ser Ala Leu Phe Ile Leu Ile Ser Tyr Val 180 185 190 Phe Ile Phe Ile Thr Val Leu Lys Ile Gln Ser Gly Glu Gly Tyr Gln 195 200 205 Lys Ser Leu Ser Thr Cys Ala Ser His Leu Val Thr Val Ser Leu Phe 210 215 220 Tyr Gly Thr Val Ile Ile Met Tyr Leu Gln Pro Ser Ser His His Ser 225 230 235 240

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Met Asp Thr Asp Lys Ile Ala Ser Val Phe Tyr Thr Met Val Thr Pro 245 250 255 Met Leu Asn Gln Val Val Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asn 260 265 270 Ala Phe Lys Lys Val Val Glu Lys Val Lys Tyr Ser Leu Gly Ile Val 275 280 285

<210> 443 <211> 297 <212> DNA <213> Canis familiaris <400> 443 acaaattata tggtcagcat caccgtcctg gccatcccct tcctgtttat cattccctcc 60 tctgtcttca tcgtggccac caacctgaag attcgcttgg ccgaggggag gccctaggcc 120 ttctccacct gctcccttca cctgactgtg gtcctgctgc agtagggatg ttccaacccc 180 agttactctc cagagagggc ccagggagtg tctgtggttt acacattcct cacccaggtg 240 ctgaacccct tgatctatag catgagaaac aagttgttta aggatgcttt taagaaa 297 <210> 444 <211> 99 <212> PRT <213> Canis familiaris <400> 444

Phe Leu Lys Ser Ile Leu Lys Gln Leu Val Ser His Ala Ile Asp Gln 1 5 10 15 Gly Val Gln His Leu Gly Glu Glu Cys Val Asn His Arg His Ser Leu 20 25 30 Gly Pro Leu Trp Arg Val Thr Gly Val Gly Thr Ser Leu Leu Gln Gln 35 40 45 Asp His Ser Gln Val Lys Gly Ala Gly Gly Glu Gly Leu Gly Pro Pro 50 55 60

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Leu Gly Gln Ala Asn Leu Gln Val Gly Gly His Asp Glu Asp Arg Gly 65 70 75 80 Gly Asn Asp Lys Gln Glu Gly Asp Gly Gln Asp Gly Asp Ala Asp His 85 90 95 Ile Ile Cys

<210> 445 <211> 1029 <212> DNA <213> Canis familiaris <400> 445

atgacttctt tcctcatacc aggtctcatg gaagaggaaa accagacagg agtggtccag 60 ttccacttcc accccttctc cacagaccca gcggtggttc ccctcctatt tgtggccttc 120 ttgctgttgt acttaggaag tcttgttgga aacatgacca ttgggctgac ggtctggaga 180 gatcactccc tccatacccc gatgtacttc ttcctttttg ttctggccgt gctggagatc 240 ggctactcta ccaacattgc tcccctgact ctggctggca tcctttccat ggggcggatg 300 cttatctctc tccctggctg tggggcccag atgttcttgt tcatccttct tggcgggtct 360 gactgtgtcc tgcttgctgt catggcctac gacaggtacg tggcaatctg tcatccgttg 420 cactacaacc tcatcatgag ttgggagctc tgtgggcaga tgactttggg ctcattgggg 480 ctgggattcc tgttgtcact gcccttgacc attctgatct gccaccttcc attctgtggc 540 cacaatgaga tccaccactt tttctgtgac atgcctgcag tcatgcgcct ggcctgcaca 600 gacacccgcc tgcatgaagc aactctctat gccctcagcg tggtggctgt ggctgtcccc 660 ttcctcctca tctgcctctc ctatggctgc atcgtggcca ccatcctgag gatgaattca 720 gctgagggaa agcgccgggc tttctccacc tgttcctccc accttatcgt cgttctcctg 780 caatatgggt gttgcagcct catctacctt cgccccagct ccagctactc cccagaagag 840 ggccgggcag tgtccgttgt ctacaccttt ttctccccag tgctaaaccc cttgatctat 900 agcataaaga atcaagaggt gactgatgca ataaggagac ttatggcaag aatgtgctgg 960 gtcaggaaac cagaaatatt tcttcctaga aaaaatattc cccaaaccag gaataagggc 1020

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069269_0225_SL.TXT atgatgtaa

1029 <210> 446 <211> 342 <212> PRT <213> Canis familiaris <400> 446

Met 1 Thr Ser Phe Leu 5 Ile Pro Gly Leu Met Glu Glu Glu Asn Gln Thr 10 15 Gly Val Val Gln Phe His Phe His Pro Phe Ser Thr Asp Pro Ala Val 20 25 30 Val Pro Leu Leu Phe Val Ala Phe Leu Leu Leu Tyr Leu Gly Ser Leu 35 40 45 Val Gly Asn Met Thr Ile Gly Leu Thr Val Trp Arg Asp His Ser Leu 50 55 60 His Thr Pro Met Tyr Phe Phe Leu Phe Val Leu Ala Val Leu Glu Ile 65 70 75 80 Gly Tyr Ser Thr Asn Ile Ala Pro Leu Thr Leu Ala Gly Ile Leu Ser 85 90 95 Met Gly Arg Met Leu Ile Ser Leu Pro Gly Cys Gly Ala Gln Met Phe 100 105 110 Leu Phe Ile Leu Leu Gly Gly Ser Asp Cys Val Leu Leu Ala Val Met 115 120 125 Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu His Tyr Asn Leu 130 135 140 Ile Met Ser Trp Glu Leu Cys Gly Gln Met Thr Leu Gly Ser Leu Gly 145 150 155 160 Leu Gly Phe Leu Leu Ser Leu Pro Leu Thr Ile Leu Ile Cys His Leu 165 170 175

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Pro Phe Cys Gly His Asn Glu Ile His His Phe Phe Cys Asp Met Pro 180 185 190 Ala Val Met Arg Leu Ala Cys Thr Asp Thr Arg Leu His Glu Ala Thr 195 200 205 Leu Tyr Ala Leu Ser Val Val Ala Val Ala Val Pro Phe Leu Leu Ile 210 215 220 Cys Leu Ser Tyr Gly Cys Ile Val Ala Thr Ile Leu Arg Met Asn Ser 225 230 235 240 Ala Glu Gly Lys Arg Arg Ala Phe Ser Thr Cys Ser Ser His Leu Ile 245 250 255 Val Val Leu Leu Gln Tyr Gly Cys Cys Ser Leu Ile Tyr Leu Arg Pro 260 265 270 Ser Ser Ser Tyr Ser Pro Glu Glu Gly Arg Ala Val Ser Val Val Tyr 275 280 285 Thr Phe Phe Ser Pro Val Leu Asn Pro Leu Ile Tyr Ser Ile Lys Asn 290 295 300 Gln Glu Val Thr Asp Ala Ile Arg Arg Leu Met Ala Arg Met Cys Trp 305 310 315 320 Val Arg Lys Pro Glu Ile Phe Leu Pro Arg Lys Asn Ile Pro Gln Thr 325 330 335 Arg Asn Lys Gly Met Met

340 <210> 447 <211> 939 <212> DNA <213> Canis familiaris <400> 447

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069269_0225_SL.TXT atgggtaaca ggacagaagt gacacagttc atcctgctgg gactaaccaa tgacccagaa 60 ctgcaggttc ctctcttcat aatgttcacc ttcatctacc tcatcactct ggttgggaat 120 ttggggatta ccgtgctgat tctcttggac tcccgtctcc acactcccat gtactttttc 180 ctcagtaacc tgtctctggc agactttggt tactctacag ctgtcacacc cacagtcatg 240 gctgggttac ttagaggaga ccaggtcatc tcctacagtg catgtgctgc tcagatgttc 300 atttttgctg tctttgccac tgtggaaaat tatctcttgg cctcaatggc ctatgaccgc 360 tacgcagcag tgtgcaaacc cctccattac accaccacta tgacgacagg tgtgtgtgct 420 tgtctggcca taggctccta tgtctgtggt ttcctgaatg cctctatcca cattggaggc 480 acatttagtc tctctttctg tatgaacaat gaagtccatc actttttctg tgatatccca 540 gcagtcatgg ttctttcttg ctctgataga cacgtcagtg agctggctct tgtttatgca 600 accactttta acatcatttt tgctctcctg gttatctttg tatcctacat attcatattt 660 atcaccatcc tgaagatgca ctcttcttca gtatacctaa aggctatatc cacctgtgct 720 tcccacctca ctgcagtgtc catcttctat ggagcagtca tcttcatgta cacacagccc 780 agctccagcc attccatgga cacagacaaa atggcatccg tgttctacac catggtcatc 840 cccatgctga accctgtggt ctacagcctg agaaacaagg aggtcaagaa tgcattcatg 900 aaaattgttt tagagtcaaa gttgtcttta ggattgtga 939 <210> 448 <211> 312 <212> PRT <213> Canis familiaris <400> 448

Met Gly Asn Arg Thr Glu Val Thr Gln Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asn Asp Pro Glu Leu Gln Val Pro Leu Phe Ile Met Phe Thr Phe Ile 20 25 30 Tyr Leu Ile Thr Leu Val Gly Asn Leu Gly Ile Thr Val Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu

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50 55 60

Ser 65 Leu Ala Asp Phe Gly Tyr Ser Thr Ala Val Thr Pro Thr Val Met 70 75 80 Ala Gly Leu Leu Arg Gly Asp Gln Val Ile Ser Tyr Ser Ala Cys Ala 85 90 95 Ala Gln Met Phe Ile Phe Ala Val Phe Ala Thr Val Glu Asn Tyr Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Thr Gly Val Cys Ala Cys Leu Ala Ile 130 135 140 Gly Ser Tyr Val Cys Gly Phe Leu Asn Ala Ser Ile His Ile Gly Gly 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys Met Asn Asn Glu Val His His Phe Phe 165 170 175 Cys Asp Ile Pro Ala Val Met Val Leu Ser Cys Ser Asp Arg His Val 180 185 190 Ser Glu Leu Ala Leu Val Tyr Ala Thr Thr Phe Asn Ile Ile Phe Ala 195 200 205 Leu Leu Val Ile Phe Val Ser Tyr Ile Phe Ile Phe Ile Thr Ile Leu 210 215 220 Lys Met His Ser Ser Ser Val Tyr Leu Lys Ala Ile Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Ala Val Ser Ile Phe Tyr Gly Ala Val Ile Phe Met 245 250 255 Tyr Thr Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala

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069269_0225_SL.TXT 265 270

Ser Val Phe Tyr Thr Met Val Ile Pro Met 280 Leu Asn Pro 285 Val Val Tyr 275 Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Phe Met Lys Ile Val Leu 290 295 300 Glu Ser Lys Leu Ser Leu Gly Leu 305 310

<210> 449 <211> 834 <212> DNA <213> Canis familiaris <400> 449 tctataactg gaaacctgta tctcctacta tccttcactc attttgccct aaaaaattat 60 ttctctgcat ttatgtgacc atttcagctt tttgttttga tgtatgctcc ctggtggact 120 gtgcttattt ccaggttgtt actccaaggt gatggctggg tttctcacag aggataaagt 180 tgtctcctgt gatggatgtg cttctcagat gtttttcttt gtggcttttg ccagtgtaga 240 ctgtttcctg ctagctgtca tgcttgtgat gggcaggcag tgatgtgaaa gttcttacat 300 tacacaccac tctgactgtt aatgcatgtg ctcagacact ggtaggctgc tgtctggggc 360 tttgttgaat ctgccatcca cactggattc accttctgcc attccaatgt gatccatccc 420 tttttctgtg atatcctccc aaccctggat ctttcccact ctgacatcta cctaaatgag 480 attgtgctct ttatcttagc agctttcaat gtctgttttg ctcttatagt tatcttgacc 540 tcctatctgt tcatcttcat tgccatcctg aggatgcgct cagctgaggg aaggaagaaa 600 gccttctcca cctgtgcctc acacctcact gctgtaacca tcttctatgg aactgtcatg 660 ttcatgtact tacaacctag ttctagtcat tctatggaca atgaccaaat ggcatctgtg 720 ttctatacca taatagtccc catgttgaac cctattgtct acagtctaag gaataaagag 780 gtgaataatg cttttaggaa agtcaccaag aagctaaaga ttctgtttgg ccca 834 <210> 450 <211> 87

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069269_0225_SL.TXT <212> PRT <213> Canis familiaris <400> 450

Met 1 Arg Ser Ala Glu Gly Arg Lys 5 Lys Ala Phe Ser Thr Cys Ala Ser 10 15 His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Val Met Phe Met Tyr 20 25 30 Leu Gln Pro Ser Ser Ser His Ser Met Asp Asn Asp Gln Met Ala Ser 35 40 45 Val Phe Tyr Thr Ile Ile Val Pro Met Leu Asn Pro Ile Val Tyr Ser 50 55 60 Leu Arg Asn Lys Glu Val Asn Asn Ala Phe Arg Lys Val Thr Lys Lys 65 70 75 80 Leu Lys Ile Leu Phe Gly Pro 85

<210> 451 <211> 945 <212> DNA <213> Canis familiaris <400> 451

atggggaaca acacagaagt gactgaattc atcctgctgg gactaactaa tgccccggag 60 ctccagatcc ccctctttat catgttcacc ctcatttacc tcatcactct ggctgggaac 120 ctgggcatgg tggtgctgat tctcttggac tcccgtctcc acactcccat gtactttttc 180 cttagtaacc tgtctctggt tgactttggt tactctacag ctgtcactcc caaagtcatg 240 gctggattac ttataaggga tcaggtcatc tcctacaatg catgtgctgc tcaaatgttc 300 ttttttgtag ccttagccac tgtggaaaat ttcctattgg cctcaatggc ttatgaccgc 360 tacacagcag tgtgcaaacc cctccattac accactacca tgacaacaag tgtatgcgct 420 catttggcca taggctccta cctctgtggt tttctgaatg cctccattca cattcatgac 480 acattcagtc tctctttttg catgtccaat ctagtccatc actttttctg tgatgtgcca 540

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gtagtcatgg ctctctcttg ctctgataga tatgtcagtg agctggttct tgttgttgta 600 gcaagcttca acatcttttt tgctctcctc attatcttga tttcctatct gttcatattt 660 atcaccatcc tgaagatgca cacagctgac ggatatcaga aggctctatc cacctgcgct 720 tcccacctca ctgcagtgtc catcttctat gggacagtca tcttcatgta cttacagccc 780 aactccagcc attccatgga cacagacaaa atcgtatctg tgttctattc tatggtcatc 840 cccatgctga atcccctagt ctatagcttg agaaacaagg aggttaaaaa tgcattcaag 900 aaggtggttg agaaggcgaa attgtctgca ggctttacct cttaa 945

<210> 452 <211> 314 <212> PRT <213> Canis familiaris <400> 452

Met Gly Asn Asn Thr Glu Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asn Ala Pro Glu Leu Gln Ile Pro Leu Phe Ile Met Phe Thr Leu Ile 20 25 30 Tyr Leu Ile Thr Leu Ala Gly Asn Leu Gly Met Val Val Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Gly Tyr Ser Thr Ala Val Thr Pro Lys Val Met 65 70 75 80 Ala Gly Leu Leu Ile Arg Asp Gln Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Ala Gln Met Phe Phe Phe Val Ala Leu Ala Thr Val Glu Asn Phe Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Thr Ala Val Cys Lys Pro Leu 115 120 125

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His Tyr Thr Thr 130 Thr Met Thr 135 Thr Ser Val Cys Ala 140 His Leu Ala Ile Gly Ser Tyr Leu Cys Gly Phe Leu Asn Ala Ser Ile His Ile His Asp 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys Met Ser Asn Leu Val His His Phe Phe 165 170 175 Cys Asp Val Pro Val Val Met Ala Leu Ser Cys Ser Asp Arg Tyr Val 180 185 190 Ser Glu Leu Val Leu Val Val Val Ala Ser Phe Asn Ile Phe Phe Ala 195 200 205 Leu Leu Ile Ile Leu Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Leu 210 215 220 Lys Met His Thr Ala Asp Gly Tyr Gln Lys Ala Leu Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Ala Val Ser Ile Phe Tyr Gly Thr Val Ile Phe Met 245 250 255 Tyr Leu Gln Pro Asn Ser Ser His Ser Met Asp Thr Asp Lys Ile Val 260 265 270 Ser Val Phe Tyr Ser Met Val Ile Pro Met Leu Asn Pro Leu Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Phe Lys Lys Val Val Glu 290 295 300 Lys Ala Lys Leu Ser Ala Gly Phe Thr Ser 305 310

<210> 453 <211> 939 <212> DNA

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069269_0225_SL.TXT <213> Canis familiaris <400> 453

atggagaata atacagaagt gatggatttc atcctggtgg gtctgactgg taccccagaa 60 cttcagattt cactttttac tgtgttcacc cttgtttacc tcatcagtgt tttaggaacc 120 tggggaaacc tggggatgac catcctgatc cttctggact cccgtctcca cactcccatg 180 tactttttcc tcagtaacct gtctctggtg gactttggtt actctacagc tgtcactccc 240 aaggtcatgg ctgggttact tagaggagac caggtcatct cctgcagtgc atgtgctgct 300 caaaagttct cttttgcagc ctttgcaaca gtggaaagtt acctcttatc ttcaatggct 360 tatgaccgct acacagcagt gtgcaaaccc ctccattaca ccaccaccat gacgacaggt 420 gtgtgtgctc gtttggccat aggctgctac acctgtggtt ttctgaatgc ttccattcat 480 gttggaaaca cattcagtct ttctttctgt aattccaacc tggtccatca ctttttctgt 540 gatattccag cagtcatggc tctctcttgc tctgataaat acattagtga ggtggctctt 600 gtgtatgtgt caagttttaa tgtctttttt gctcttctgg ttataatcat atcttaccta 660 ttcatattta taaccatatt aaggatgcaa tcacctcaag agctccaaaa ggctttgtcc 720 acctgtgctt ctcacctcac tgcagtctcc atattctatg ggacaattat cttcatgtac 780 ttacagccca gctccagcca ttccatggac acagacaaaa tagcatccgt gttctacacc 840 atggccatct ccatgctgaa ccctgtggtc tacggcctga gaaataaaga ggtcaagagt 900 gctttcaaga aattttcaga gaaggcaaaa tcatctcta 939

<210> 454 <211> 313 <212> PRT <213> Canis familiaris <400> 454

Met 1 Glu Asn Asn Thr Glu Val Met Asp Phe Ile Leu Val Gly Leu Thr 5 10 15 Gly Thr Pro Glu Leu Gln Ile Ser Leu Phe Thr Val Phe Thr Leu Val 20 25 30 Tyr Leu Ile Ser Val Leu Gly Thr Trp Gly Asn Leu Gly Met Thr Ile 35 40 45

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Leu Ile 50 Leu Leu Asp Ser Arg Leu 55 His Thr Pro Met Tyr Phe Phe 60 Leu Ser Asn Leu Ser Leu Val Asp Phe Gly Tyr Ser Thr Ala Val Thr Pro 65 70 75 80 Lys Val Met Ala Gly Leu Leu Arg Gly Asp Gln Val Ile Ser Cys Ser 85 90 95 Ala Cys Ala Ala Gln Lys Phe Ser Phe Ala Ala Phe Ala Thr Val Glu 100 105 110 Ser Tyr Leu Leu Ser Ser Met Ala Tyr Asp Arg Tyr Thr Ala Val Cys 115 120 125 Lys Pro Leu His Tyr Thr Thr Thr Met Thr Thr Gly Val Cys Ala Arg 130 135 140 Leu Ala Ile Gly Cys Tyr Thr Cys Gly Phe Leu Asn Ala Ser Ile His 145 150 155 160 Val Gly Asn Thr Phe Ser Leu Ser Phe Cys Asn Ser Asn Leu Val His 165 170 175 His Phe Phe Cys Asp Ile Pro Ala Val Met Ala Leu Ser Cys Ser Asp 180 185 190 Lys Tyr Ile Ser Glu Val Ala Leu Val Tyr Val Ser Ser Phe Asn Val 195 200 205 Phe Phe Ala Leu Leu Val Ile Ile Ile Ser Tyr Leu Phe Ile Phe Ile 210 215 220 Thr Ile Leu Arg Met Gln Ser Pro Gln Glu Leu Gln Lys Ala Leu Ser 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Val Ser Ile Phe Tyr Gly Thr Ile 245 250 255

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Ile Phe Met Tyr Leu Gln Pro Ser Ser 265 Ser His Ser Met Asp 270 Thr Asp 260 Lys Ile Ala Ser Val Phe Tyr Thr Met Ala Ile Ser Met Leu Asn Pro 275 280 285 Val Val Tyr Gly Leu Arg Asn Lys Glu Val Lys Ser Ala Phe Lys Lys 290 295 300 Phe Ser Glu Lys Ala Lys Ser Ser Leu 305 310

<210> 455 <211> 945 <212> DNA <213> Canis familiaris <400> 455

atggataata ggacagaagg gacacagttc atcctgctgg gactaaccaa tgccccagag 60 ctccagatcc ccctttttat catgttcact ctcatttacc tcatcactct ggctgggaac 120 ctgggcatga tgatgctgat tctcttggac tcccgtctcc acactcccat gtactttttt 180 ctcagtaacc tgtctctggt ggactttggt tactctacag ctgtcactcc caaggtcatg 240 gctgggttac ttaggggaga ccaggtcatc tcctacaatg catgtgctgc tcagatgttc 300 ttttttgtag cctttgccac tgtggaaaat tatctcttgg cctcaatggc ctatgaccgc 360 tacgcggccg tgtgcaaacc cctccattac accaccacca tgacgacagg ggtgtgtgct 420 cgtctggcca taggctccta catctgtggt ttcctgaatg cttccttcca tgttggggac 480 atatttagtc tgtctttatg taattccaat ccagtccatc actttttctg tgatgttcca 540 gcggtcatgg ctctctcttg ttctgataaa cacattagtg aggtgtttct tgtttttatg 600 tcaagtttta atgccctttt tgctcttctg gttatattga tttcctacct tttcatattt 660 ataaccatct tgaaggtgca gtcagctcaa gggcatcaaa aagctttatc cacctgtgct 720 tcccacctca ctacagtgtc catcttctat gggacagtca tcttcatgta cttacagccc 780 agctccagcc attccatgga cacagacaaa atcgcatctg tgttctattc tatggtcatc 840

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900

945

069269_0225_SL.TXT cccatgctga atcccctggt ctatagcctg aggaacaaag aggtcaagtg tgcattcaag aaggtggtgg aaaaggcaat tttttcaata ggattggcaa tctaa <210> 456 <211> 314 <212> PRT <213> Canis familiaris <400> 456

Met Asp Asn Arg Thr Glu Gly Thr Gln Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asn Ala Pro Glu Leu Gln Ile Pro Leu Phe Ile Met Phe Thr Leu Ile 20 25 30 Tyr Leu Ile Thr Leu Ala Gly Asn Leu Gly Met Met Met Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Gly Tyr Ser Thr Ala Val Thr Pro Lys Val Met 65 70 75 80 Ala Gly Leu Leu Arg Gly Asp Gln Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Ala Gln Met Phe Phe Phe Val Ala Phe Ala Thr Val Glu Asn Tyr Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Thr Gly Val Cys Ala Arg Leu Ala Ile 130 135 140 Gly Ser Tyr Ile Cys Gly Phe Leu Asn Ala Ser Phe His Val Gly Asp 145 150 155 160 Ile Phe Ser Leu Ser Leu Cys Asn Ser Asn Pro Val His His Phe Phe

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165 170 175

Cys Asp Val Pro 180 Ala Val Met Ala Leu Ser Cys Ser Asp Lys His Ile 185 190 Ser Glu Val Phe Leu Val Phe Met Ser Ser Phe Asn Ala Leu Phe Ala 195 200 205 Leu Leu Val Ile Leu Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Leu 210 215 220 Lys Val Gln Ser Ala Gln Gly His Gln Lys Ala Leu Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Thr Val Ser Ile Phe Tyr Gly Thr Val Ile Phe Met 245 250 255 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Ile Ala 260 265 270 Ser Val Phe Tyr Ser Met Val Ile Pro Met Leu Asn Pro Leu Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Cys Ala Phe Lys Lys Val Val Glu 290 295 300 Lys Ala Ile Phe Ser Ile Gly Leu Ala Ile 305 310

<210> 457 <211> 498 <212> DNA <213> Canis familiaris <400> 457 ttgggaatga tggtgctgat tctcttggac tcccgtctcc atgctgtcat gtactttttc ctcagtaacc tgtctctggt ggactttggt tactctacag ctgtcactcc caaggtcatg gctggattac ttaaaggaga caaggtcatc tcctacaatt catgtcctgc tcagatgttc ttttttgtag cccttgtcac tgtggaattg gtctatgact gccacacagc tgtgtgtaaa Page 507

120

180

240

069269_0225_SL.TXT ctcctacatt acaccaccat aatgactgcc agtgtgtgtg cacatgttgc catacattcc tacttttttg gtttcctaaa tgcccccatt cacattcagg acatggtcag tctccttttc tgcatgtcca atctagtcca ccactttttc tgtgatgttc cagcagtcac agctctccct tattctgata gacatgtcag tgagctggtt tttgttgttg tcactagttt caatattatt tttgctctcc tcattatg

300

360

420

480

498 <210> 458 <211> 166 <212> PRT <213> Canis familiaris <400> 458

Leu 1 Gly Met Met Val Leu Ile Leu Leu Asp Ser Arg Leu His Ala Val 5 10 15 Met Tyr Phe Phe Leu Ser Asn Leu Ser Leu Val Asp Phe Gly Tyr Ser 20 25 30 Thr Ala Val Thr Pro Lys Val Met Ala Gly Leu Leu Lys Gly Asp Lys 35 40 45 Val Ile Ser Tyr Asn Ser Cys Pro Ala Gln Met Phe Phe Phe Val Ala 50 55 60 Leu Val Thr Val Glu Leu Val Tyr Asp Cys His Thr Ala Val Cys Lys 65 70 75 80 Leu Leu His Tyr Thr Thr Ile Met Thr Ala Ser Val Cys Ala His Val 85 90 95 Ala Ile His Ser Tyr Phe Phe Gly Phe Leu Asn Ala Pro Ile His Ile 100 105 110 Gln Asp Met Val Ser Leu Leu Phe Cys Met Ser Asn Leu Val His His 115 120 125 Phe Phe Cys Asp Val Pro Ala Val Thr Ala Leu Pro Tyr Ser Asp Arg

130 135 140

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His Val Ser Glu Leu Val Phe Val Val Val Thr Ser Phe Asn Ile Ile 145 150 155 160

Phe Ala Leu Leu Ile Met 165 <210> 459 <211> 939 <212> DNA <213> Canis familiaris <400> 459 atgggtaaca ggacagaagt gacacagttc atcctgctgg gactaaccaa tgacccagaa 60 ctgcaggttc ctctcttcat aatgttcacc ttcatctacc tcatcactct ggttgggaat 120 ttggggatta ccgtgctgat tctcttggac tcccgtctcc acactcccat gtactttttc 180 ctcagtaacc tgtctctggc agactttggt tactctacag ctgtcacacc cacagtcatg 240 gctgggttac ttctaggaga ccaggtcatc tcctacagtg catgtgctgc tcagatgttc 300 gtttttgctg tctttgccac tgtggaaaat tatctcttgg cctcaatggc ctatgaccgc 360 tacgcagcag tgtgcaaacc cctccattac accaccacta tgacgacagg tgtgtgtgct 420 cgtctggcca taggctgcta tatctttggt ttcctgaatg cttctattta cattggagac 480 acatttagtc tctctttctg tatgaacaat gaagtccatc actttttctg tgatatccca 540 gcagtcatgg ttctttcttg ctctgataga tatgtcaatg agctgattct tatttatgta 600 gtgagcttca acatcttttt tgctctcctg gttatcttaa tttcctacat attcatattt 660 atcaccatcc tgaatatgca ctcatctggt ggatatcaga aggctattgc cacctgtgct 720 tcccacctca ctgcagtgtc catcttctat gggacagtca tcttcatgta tacacagccc 780 agctccagcc attccatgga cacagacaaa atggcatccg tgttctacac tatggttatc 840 cccatgctga accctatggt ctacagcatg aggaacaagg aggtcaagaa tgctttcaag 900 aagattgttt tagagtcaaa attgtcttta ggattgtga 939 <210> 460 <211> 312 <212> PRT

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069269_0225_SL.TXT <213> Canis familiaris <400> 460

Met 1 Gly Asn Arg Thr 5 Glu Val Thr Gln Phe Ile Leu Leu Gly Leu Thr 10 15 Asn Asp Pro Glu Leu Gln Val Pro Leu Phe Ile Met Phe Thr Phe Ile 20 25 30 Tyr Leu Ile Thr Leu Val Gly Asn Leu Gly Ile Thr Val Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Ala Asp Phe Gly Tyr Ser Thr Ala Val Thr Pro Thr Val Met 65 70 75 80 Ala Gly Leu Leu Leu Gly Asp Gln Val Ile Ser Tyr Ser Ala Cys Ala 85 90 95 Ala Gln Met Phe Val Phe Ala Val Phe Ala Thr Val Glu Asn Tyr Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Thr Gly Val Cys Ala Arg Leu Ala Ile 130 135 140 Gly Cys Tyr Ile Phe Gly Phe Leu Asn Ala Ser Ile Tyr Ile Gly Asp 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys Met Asn Asn Glu Val His His Phe Phe 165 170 175 Cys Asp Ile Pro Ala Val Met Val Leu Ser Cys Ser Asp Arg Tyr Val 180 185 190 Asn Glu Leu Ile Leu Ile Tyr Val Val Ser Phe Asn Ile Phe Phe Ala

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195 069269_0225_SL.TXT 200 205 Leu Leu Val Ile Leu Ile Ser Tyr Ile Phe Ile Phe Ile Thr Ile Leu 210 215 220 Asn Met His Ser Ser Gly Gly Tyr Gln Lys Ala Ile Ala Thr Cys Ala 225 230 235 240 Ser His Leu Thr Ala Val Ser Ile Phe Tyr Gly Thr Val Ile Phe Met 245 250 255 Tyr Thr Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala 260 265 270 Ser Val Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Met Val Tyr 275 280 285 Ser Met Arg Asn Lys Glu Val Lys Asn Ala Phe Lys Lys Ile Val Leu 290 295 300 Glu Ser Lys Leu Ser Leu Gly Leu 305 310

<210> 461 <211> 948 <212> DNA <213> Canis familiaris <400> 461

atggagaaca atacagaggt gtctgatttc atcctgttgg gactaaccaa tgccccagag 60 ctgcagattc ctctttttgt aatattcatc ctcatttacc tcatcactct gcttgggaac 120 ctggggatga tcacactgat cttgctggac tctcgtctcc atactcctat gtactttttc 180 ctcagtaatc tgtctctggt agacttttgt tactcctcaa cagtcactcc caaggtcatg 240 gctgggctcc ttataggaga caaggtcatt tcctacaatg catgtgctgc ccagatgttc 300 ttttttgcag tctttgctac tgtggaaaat tacctcttag catcaatggc ctatgactgc 360 tatatagcag tgtgtaaacc cctccattat gccaccacca tgacgacagg tgtgtgtgct 420 catctcacca tagtctccta tgcctgtggc atcttaaatg catctgtaaa tgttgtagat 480

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accttcagtc tctctttctg tatgtccagt gttgttcatc attttttctg tgatattcca 540 gcagtcatgg ctctgtcgtg ctctgataaa cacttcagtg agctgattct catttttatc 600 tcaagcttta atgtgttttt tgcacttttt gttatcttta tttcctatct gttcatattt 660 attaccattt tgaagataaa gtcaggtgag ggataccaga aggctttgtc tacctgtgct 720 tctcaccttg ttacagtttc cttattttat gggacagtca tcatcatgta cttacagcca 780 agttctcatc attccatgga cacagacaaa atcgcatctg tgttctatac tatggtcatc 840 cccatgctga accctgtggt ctacagcttg aggaacaaag aggtcaagaa tgcattcaag 900 aaggttgctg agaaggcaaa atattctcta ggtgtggtct ataaatga 948

<210> 462 <211> 315 <212> PRT <213> Canis familiaris <400> 462

Met Glu Asn Asn Thr Glu Val Ser Asp Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asn Ala Pro Glu Leu Gln Ile Pro Leu Phe Val Ile Phe Ile Leu Ile 20 25 30 Tyr Leu Ile Thr Leu Leu Gly Asn Leu Gly Met Ile Thr Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Cys Tyr Ser Ser Thr Val Thr Pro Lys Val Met 65 70 75 80 Ala Gly Leu Leu Ile Gly Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Ala Gln Met Phe Phe Phe Ala Val Phe Ala Thr Val Glu Asn Tyr Leu 100 105 110

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Leu Ala Ser 115 Met Ala Tyr Asp 069269_0225_SL.TXT Cys Tyr Ile Ala Val Cys 120 125 Lys Pro Leu His Tyr Ala Thr Thr Met Thr Thr Gly Val Cys Ala His Leu Thr Ile 130 135 140 Val Ser Tyr Ala Cys Gly Ile Leu Asn Ala Ser Val Asn Val Val Asp 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys Met Ser Ser Val Val His His Phe Phe 165 170 175 Cys Asp Ile Pro Ala Val Met Ala Leu Ser Cys Ser Asp Lys His Phe 180 185 190 Ser Glu Leu Ile Leu Ile Phe Ile Ser Ser Phe Asn Val Phe Phe Ala 195 200 205 Leu Phe Val Ile Phe Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Leu 210 215 220 Lys Ile Lys Ser Gly Glu Gly Tyr Gln Lys Ala Leu Ser Thr Cys Ala 225 230 235 240 Ser His Leu Val Thr Val Ser Leu Phe Tyr Gly Thr Val Ile Ile Met 245 250 255 Tyr Leu Gln Pro Ser Ser His His Ser Met Asp Thr Asp Lys Ile Ala 260 265 270 Ser Val Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Val Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Phe Lys Lys Val Ala Glu 290 295 300 Lys Ala Lys Tyr Ser Leu Gly Val Val Tyr Lys 305 310 315

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069269_0225_SL.TXT <210> 463 <211> 945 <212> DNA <213> Canis familiaris <400> 463

atgaagaaca acacaaaagt gactgagttc atcctactgg gactaaccaa tgccccagag 60 ctacagatcc ccctctttat catgttcacc ctcatttacc tcatcactct ggctgggaac 120 ctgggcatga tgatgttgat tctcttggac tcccatctcc acactcccat gtactttttt 180 ctcagtaacc tctctctggt ggactttggt tactctacag ctgtcactcc caaggtcatg 240 gctgggttac ttagaggaga ccaggtcatc tcctacaatg catgtgctgc tcagatgttc 300 ttttttgtag cctttgccac tgtggaaaat tatctcttga cctcaatggc ctatgaccgc 360 tatgtggctg tgtgcaaacc cctccattac gccaccacca tgacaacagg ggtgtgtgct 420 tggctatcca taggctgcta cttctgtgga tttctaaaca cctcaatcca tacttggaac 480 atttttaggc tctccttctg taattccaat gtgatccatc actttttctg tgatgtaccg 540 gcagtcatga ctctctcttg ctctaataga catgtcagtg agctggttct tgtctttgta 600 gcagtcttca acatattttt tgctctcctc attatcttga tttcctactt attcattttt 660 atcactatcc tgaagatgcc ctcagtggag ggatacctga aggccatatc cacctgcgtc 720 tcccacctca ctgcagtgtc catcttctat gggtcattca tcttcatgta catacagccc 780 acctccagct actctatgga cacagacaaa atcgcatctg tgttctattc tatgatcatc 840 cccatgctga atcccctggt ctatagcctg aggaacaaag acgtcaagaa tgctttcaat 900 aaagttgttg agaaggttaa actgccttta agcttcacct cttag 945

<210> 464 <211> 314 <212> PRT <213> Canis familiaris <400> 464

Met Lys Asn Asn Thr Lys Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15

Asn Ala Pro Glu Leu Gln Ile Pro Leu Phe Ile Met Phe Thr Leu Ile 20 25 30

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Tyr Leu Ile Thr 35 Leu Ala Gly Asn Leu Gly Met Met Met Leu Ile Leu 40 45 Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Gly Tyr Ser Thr Ala Val Thr Pro Lys Val Met 65 70 75 80 Ala Gly Leu Leu Arg Gly Asp Gln Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Ala Gln Met Phe Phe Phe Val Ala Phe Ala Thr Val Glu Asn Tyr Leu 100 105 110 Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Lys Pro Leu 115 120 125 His Tyr Ala Thr Thr Met Thr Thr Gly Val Cys Ala Trp Leu Ser Ile 130 135 140 Gly Cys Tyr Phe Cys Gly Phe Leu Asn Thr Ser Ile His Thr Trp Asn 145 150 155 160 Ile Phe Arg Leu Ser Phe Cys Asn Ser Asn Val Ile His His Phe Phe 165 170 175 Cys Asp Val Pro Ala Val Met Thr Leu Ser Cys Ser Asn Arg His Val 180 185 190 Ser Glu Leu Val Leu Val Phe Val Ala Val Phe Asn Ile Phe Phe Ala 195 200 205 Leu Leu Ile Ile Leu Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Leu 210 215 220 Lys Met Pro Ser Val Glu Gly Tyr Leu Lys Ala Ile Ser Thr Cys Val 225 230 235 240

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Ser His Leu Thr Ala 245 Val Tyr Ile Gln Pro 260 Thr Ser Ser Val Phe 275 Tyr Ser Met Ser Leu 290 Arg Asn Lys Asp Lys 305 Val Lys Leu Pro Leu 310

Ser Ile Phe Tyr 250 Gly Ser Tyr Ser 265 Met Asp Ile Ile 280 Pro Met Leu Val 295 Lys Asn Ala Phe Ser Phe Thr Ser

Ser Phe Ile Phe 255 Met Thr Asp Lys 270 Ile Ala Asn Pro 285 Leu Val Tyr Asn Lys Val Val Glu

300 <210> 465 <211> 945 <212> DNA <213> Canis familiaris <400> 465 atggagaaca acacaaaagt ctgcagatcc ccctctttat ctgggcatgg tggtgctgat ctcagcaacc tgtctctggt gctgggttac ttagaggaga ttttttgcag cctttgcaac tatgtggccg tgtgcaaacc cgtctggcca taggctccta acattccatc tctccttctg gcagtcatgg ctctctcttg gcaagcttcc acatctttct atcaccatcc tgaaaatacc tcccacctca ctgcagtatc gactgagttc atcctagtgg catgttcacc ctcatttacc tctcttggac tcctgtctcc ggactttggt tactctacag ccaggtcatc tcctacaatg agtggaaagt tacctcttag cctccattac accaccacca tatgtctggt tttctgaatg taattccaat gtgatccatc ctctaataga catgtcagtg tgctctcctc attatcttga ctcagtggag ggatacctga catcttctat gggacagtca Page 516 gactaaccaa taccccagag tcttcactct ggctgggaac acactcccat gtactttttt ctgtcactcc caaggtcatg catgtgctgc tcagatgttc cttcaatggc ctatgaccgg tgacgacagg tgtgtgtgct cttctgtaga tgttggagat actttttctg tgatattcct agctggttct tgtctttgta tttcctactt gttcattttt aggccgtatc cacctgcgcc tcttcatgta ctcccagccc

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069269_0225_SL.TXT acctccaacc actctatgga cacagacaaa atcatatctg tgttctatac tgtaatcatc cccatgctaa atcccatggt gtatagcctg aggaacaaag aggtaaagaa tgctttcaag aaggttgttg agaaggtaaa actgtctcta agcttcacct cttag

840

900

945 <210> 466 <211> 314 <212> PRT <213> Canis familiaris <400> 466

Met Glu 1 Asn Asn Thr Lys Val Thr Glu Phe Ile Leu Val Gly Leu Thr 5 10 15 Asn Thr Pro Glu Leu Gln Ile Pro Leu Phe Ile Met Phe Thr Leu Ile 20 25 30 Tyr Leu Phe Thr Leu Ala Gly Asn Leu Gly Met Val Val Leu Ile Leu 35 40 45 Leu Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Gly Tyr Ser Thr Ala Val Thr Pro Lys Val Met 65 70 75 80 Ala Gly Leu Leu Arg Gly Asp Gln Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Ala Gln Met Phe Phe Phe Ala Ala Phe Ala Thr Val Glu Ser Tyr Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Thr Gly Val Cys Ala Arg Leu Ala Ile 130 135 140 Gly Ser Tyr Met Ser Gly Phe Leu Asn Ala Ser Val Asp Val Gly Asp 145 150 155 160

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Thr Phe His Leu Ser 165 Phe Cys Asn Ser Asn Val Ile His His Phe Phe 170 175 Cys Asp Ile Pro Ala Val Met Ala Leu Ser Cys Ser Asn Arg His Val 180 185 190 Ser Glu Leu Val Leu Val Phe Val Ala Ser Phe His Ile Phe Leu Ala 195 200 205 Leu Leu Ile Ile Leu Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Leu 210 215 220 Lys Ile Pro Ser Val Glu Gly Tyr Leu Lys Ala Val Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Ala Val Ser Ile Phe Tyr Gly Thr Val Ile Phe Met 245 250 255 Tyr Ser Gln Pro Thr Ser Asn His Ser Met Asp Thr Asp Lys Ile Ile 260 265 270 Ser Val Phe Tyr Thr Val Ile Ile Pro Met Leu Asn Pro Met Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Phe Lys Lys Val Val Glu 290 295 300 Lys Val Lys Leu Ser Leu Ser Phe Thr Ser

305 310 <210> 467 <211> 930 <212> DNA <213> Canis familiaris <400> 467 atggaagaaa tgaataaaac tgcaaagata cagttcttct ttcacccatt ctcagctgac cccaagatcc aggtggggat ttttgtggcc ttcctggtga tgtacctgac cagcctcggt

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ggaaacacca caattgcagt ccttgtccag atcaacccct ccctccacat ccccatgtac 180 ttcttcctgg ctaacctggc agtcctggaa atcttctata cctctgccat tgccccactg 240 gctttggcaa acctcctttc aatgggcaaa actcctgttt ctatccccgg atgtggggcc 300 cagatgttct tcttcatctt cttgggtgga gctgactgtg tcctgctggc cgtcatggct 360 tacgaccggt ttgtggcaat ctgttaccct ctgagataca cccgcatcat gagctggccc 420 ttgtgtgtgg agctgatggt cgggtccctg gtgctggggt tcctgctgtc gctgccgctg 480 actattttaa tcttccatct cccattctgt ggccacaacg agatccacca cttctactgt 540 gacatgcctg cagtcatgcg cctggcctgc gcagacacac acactcacca gactgccctg 600 tacatcatca gcttcatcgt cctgagcgtc cccctgtcct taatctccac ctcctacatc 660 ttcatcatgg cagccatttt acggatccgg tcagcagaag ggcgccaccg agccttctct 720 acctgttcct cccacatctt agtggtcctc ctgcagtatg gctgcaccag ctttatctac 780 ttgtcccccc ggtccagcta ctctcctgag atgggccgag tggtgtctgt ggtctacact 840 ttcatcactc ccattttaaa ccccttgatc tacagtatga ggaacaggga actgaaagat 900 gccctaagga gggcactgag gaagttctag 930

<210> 468 <211> 309 <212> PRT <213> Canis familiaris <400> 468

Met 1 Glu Glu Met Asn Lys Thr Ala Lys Ile Gln Phe Phe Phe His Pro 5 10 15 Phe Ser Ala Asp Pro Lys Ile Gln Val Gly Ile Phe Val Ala Phe Leu 20 25 30 Val Met Tyr Leu Thr Ser Leu Gly Gly Asn Thr Thr Ile Ala Val Leu 35 40 45 Val Gln Ile Asn Pro Ser Leu His Ile Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ala Val Leu Glu Ile Phe Tyr Thr Ser Ala Ile Ala Pro Leu

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Ala Leu Ala Asn Leu Leu Ser Met Gly Lys Thr Pro Val Ser Ile Pro 85 90 95 Gly Cys Gly Ala Gln Met Phe Phe Phe Ile Phe Leu Gly Gly Ala Asp 100 105 110 Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys 115 120 125 Tyr Pro Leu Arg Tyr Thr Arg Ile Met Ser Trp Pro Leu Cys Val Glu 130 135 140 Leu Met Val Gly Ser Leu Val Leu Gly Phe Leu Leu Ser Leu Pro Leu 145 150 155 160 Thr Ile Leu Ile Phe His Leu Pro Phe Cys Gly His Asn Glu Ile His 165 170 175 His Phe Tyr Cys Asp Met Pro Ala Val Met Arg Leu Ala Cys Ala Asp 180 185 190 Thr His Thr His Gln Thr Ala Leu Tyr Ile Ile Ser Phe Ile Val Leu 195 200 205 Ser Val Pro Leu Ser Leu Ile Ser Thr Ser Tyr Ile Phe Ile Met Ala 210 215 220 Ala Ile Leu Arg Ile Arg Ser Ala Glu Gly Arg His Arg Ala Phe Ser 225 230 235 240 Thr Cys Ser Ser His Ile Leu Val Val Leu Leu Gln Tyr Gly Cys Thr 245 250 255 Ser Phe Ile Tyr Leu Ser Pro Arg Ser Ser Tyr Ser Pro Glu Met Gly 260 265 270 Arg Val Val Ser Val Val Tyr Thr Phe Ile Thr Pro Ile Leu Asn Pro

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275 280 285

Leu Ile Tyr Ser Met Arg Asn Arg Glu Leu Lys Asp Ala Leu Arg Arg 290 295 300

Ala Leu Arg Lys Phe 305 <210> 469 <211> 954 <212> DNA <213> Canis familiaris <400> 469 atgactttga tggagaacgt ttcagaggtg actgaattca ttcttgtggg gttaacagat 60 gccctggaga tgcaggtccc tttatttaca gtcttcacta tcatttactt catcattctg 120 gttgggaatg ctgggatgat cgtgttgatt ctgctggatt ctcgtctcca cactcccatg 180 tacttcttcc tcagcaacct ctcctttgta gactgtgttt atgcctcagc tgtcactccc 240 aaggtaatgg tgggatttct cacaaaagat aagatcatct cctacaatgc atgtgctgcc 300 cagatgttct tcttttcagc ctttgccact attgaaagtt ttcttttggc ctcaatggct 360 tttgaccgcc acacagcagt gtgtaaaccc ctgcattacg ccaccatcat gacaagtgct 420 atgtatacct cactggccac tggttcctac atctctggac tcttgcagtc ttccatccat 480 gttgccctca cctttcacct ctccttctgt cgttccaaca taattaatca ctttttctgt 540 gacattcccg cactgttggc tctctcttgc tctgatatct acatgaatga gattgtgctc 600 ttcatattgg cagcattcaa tgtccttttc accctcttgg ttatcttgaa ttcttatctg 660 ttcattttta ttgctatcct gggaatgcac tcagctgagg gacagaagaa ggctttctcc 720 acctgtgcat cccacctgac cactgtctcc atcttctatg ggacaatcat cttcatgtac 780 ttgcagccaa cttctagtca ttccatggac acagacaaaa tggcatccat attctacacc 840 atggtcatcc ccatgctgaa ccctttgatc tatagtctaa ggaacaaaga ggtcaagagt 900 gcatttcaga aagtggttgg aaaagcaaag tcttcagtgg gtttagccta ctaa 954 <210> 470 <211> 317

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069269_0225_SL.TXT <212> PRT <213> Canis familiaris <400> 470

Met Thr Leu Met Glu Asn Val Ser Glu Val Thr Glu Phe Ile Leu Val 1 5 10 15 Gly Leu Thr Asp Ala Leu Glu Met Gln Val Pro Leu Phe Thr Val Phe 20 25 30 Thr Ile Ile Tyr Phe Ile Ile Leu Val Gly Asn Ala Gly Met Ile Val 35 40 45 Leu Ile Leu Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Phe Val Asp Cys Val Tyr Ala Ser Ala Val Thr Pro 65 70 75 80 Lys Val Met Val Gly Phe Leu Thr Lys Asp Lys Ile Ile Ser Tyr Asn 85 90 95 Ala Cys Ala Ala Gln Met Phe Phe Phe Ser Ala Phe Ala Thr Ile Glu 100 105 110 Ser Phe Leu Leu Ala Ser Met Ala Phe Asp Arg His Thr Ala Val Cys 115 120 125 Lys Pro Leu His Tyr Ala Thr Ile Met Thr Ser Ala Met Tyr Thr Ser 130 135 140 Leu Ala Thr Gly Ser Tyr Ile Ser Gly Leu Leu Gln Ser Ser Ile His 145 150 155 160 Val Ala Leu Thr Phe His Leu Ser Phe Cys Arg Ser Asn Ile Ile Asn 165 170 175 His Phe Phe Cys Asp Ile Pro Ala Leu Leu Ala Leu Ser Cys Ser Asp 180 185 190

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Ile Tyr Met 195 Asn Glu Ile Val 069269_0225_SL.TXT Leu Phe Ile Leu Ala Ala 200 205 Phe Asn Val Leu Phe Thr Leu Leu Val Ile Leu Asn Ser Tyr Leu Phe Ile Phe Ile 210 215 220 Ala Ile Leu Gly Met His Ser Ala Glu Gly Gln Lys Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Thr Thr Val Ser Ile Phe Tyr Gly Thr Ile 245 250 255 Ile Phe Met Tyr Leu Gln Pro Thr Ser Ser His Ser Met Asp Thr Asp 260 265 270 Lys Met Ala Ser Ile Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Phe Gln Lys 290 295 300 Val Val Gly Lys Ala Lys Ser Ser Val Gly Leu Ala Tyr 305 310 315

<210> 471 <211> 960 <212> DNA <213> Canis familiaris <400> 471

atgttcgcta ggagccctgt cctcaaccaa tccggcccca ctgagttctt cttccgcgtg 60 ttgaccaccg tcccagaatt ccaggccctg ctcttcctcc tcttcctcct cctctacttg 120 atgatcctct gtggcaacac agccatcatc tgggtggtgt gcacgcacag ctccctccgc 180 acccccatgt acttcttcct ctgcaacctg gcctttgtag agatcagcta caccacggtg 240 gtggtgcctc tgatgctttc caacatttgg ggagccccga agcccatccc cctggctggc 300 tgtggggccc agatgttctt ttttctcact cttggtggtg ctgactgctt tctcttggca 360 atcatggcct acgatcgcta tgtggccatc tgccacccgc tgcactacac cctcatcatg 420

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acccagaagc tgtgcgccca gatggtggcg tgcgcggtgg gcctggccct ggtcctctcc 480 ctgcagctca cgtccttaat cttcaccctg cccttctgcg ggcaccgcca ggagatcaac 540 cacttcctgt gcgatgtgcc cccggtcctg cggctggcct gcgccgacat ccgcgtgcac 600 caggccgtcc tctacgtggt gggcatcctc gtgctgaccg tccccttcct gctcatctgt 660 gtgtcctatg tgttcatcgc ctcggccatc ctgcgcatcc gctccgccga gggccgccgc 720 cgggccttct ccacctgctc ctcgcacctc accgtggtcc tgctgcagta cggcttctgt 780 gccgtggtct acctgcggcc ccagtccacc tcctcggtgg acgaggaccg ccagtttgcc 840 ctggtctaca cctttgtcac ccccctcctc aacccgctga tttacaccct cagaaacaaa 900 gatgtcaaag gtgctttgaa aaaggccatc agtagcaaag cagcatctga agctctctga 960

<210> 472 <211> 319 <212> PRT <213> Canis familiaris <400> 472

Met Phe Ala Arg Ser Pro Val Leu Asn Gln Ser Gly Pro Thr Glu Phe 1 5 10 15 Phe Phe Arg Val Leu Thr Thr Val Pro Glu Phe Gln Ala Leu Leu Phe 20 25 30 Leu Leu Phe Leu Leu Leu Tyr Leu Met Ile Leu Cys Gly Asn Thr Ala 35 40 45 Ile Ile Trp Val Val Cys Thr His Ser Ser Leu Arg Thr Pro Met Tyr 50 55 60 Phe Phe Leu Cys Asn Leu Ala Phe Val Glu Ile Ser Tyr Thr Thr Val 65 70 75 80 Val Val Pro Leu Met Leu Ser Asn Ile Trp Gly Ala Pro Lys Pro Ile 85 90 95 Pro Leu Ala Gly Cys Gly Ala Gln Met Phe Phe Phe Leu Thr Leu Gly 100 105 110

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Gly Ala Asp 115 Cys Phe Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val 120 125 Ala Ile Cys His Pro Leu His Tyr Thr Leu Ile Met Thr Gln Lys Leu 130 135 140 Cys Ala Gln Met Val Ala Cys Ala Val Gly Leu Ala Leu Val Leu Ser 145 150 155 160 Leu Gln Leu Thr Ser Leu Ile Phe Thr Leu Pro Phe Cys Gly His Arg 165 170 175 Gln Glu Ile Asn His Phe Leu Cys Asp Val Pro Pro Val Leu Arg Leu 180 185 190 Ala Cys Ala Asp Ile Arg Val His Gln Ala Val Leu Tyr Val Val Gly 195 200 205 Ile Leu Val Leu Thr Val Pro Phe Leu Leu Ile Cys Val Ser Tyr Val 210 215 220 Phe Ile Ala Ser Ala Ile Leu Arg Ile Arg Ser Ala Glu Gly Arg Arg 225 230 235 240 Arg Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Leu Leu Gln 245 250 255 Tyr Gly Phe Cys Ala Val Val Tyr Leu Arg Pro Gln Ser Thr Ser Ser 260 265 270 Val Asp Glu Asp Arg Gln Phe Ala Leu Val Tyr Thr Phe Val Thr Pro 275 280 285 Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly 290 295 300 Ala Leu Lys Lys Ala Ile Ser Ser Lys Ala Ala Ser Glu Ala Leu

305 310 315

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069269_0225_SL.TXT <210> 473 <211> 945 <212> DNA <213> Canis familiaris <400> 473 atgacctggg gaaatcgctc actgttgatg gaatttgggt tcctggccta tccctcccac 60 ccagagctcc gtgtcttgtc cttccttgga gtcagcctaa tttatacctt gatcatcagt 120 gggaatgttc taattgtagt ggccatccag acagaagccc gcctacacac acccatgtac 180 tatttcttgg gaagcctctc gggaatagaa atatgctaca ctgctgtggt ggtgccccac 240 atcttggcca acatcctacg gccagagaag accatcaccc tcctgggctg tgccactcag 300 atgatcttct tcatcgggct cggcagtgcc gattgcttcc tcttggctgc catggcctat 360 gaccggtatg ttgctatttg ccaccctttg cagtaccctc tcaccatgac tttaactctc 420 tgtgtccgct tggtcatggc ctctgtggtg attggcttgt tcctgtccac acaactggtg 480 gccttcatct tctctctgcc attctgccgg gctcggagta tcgagcattt cttttgtgat 540 gtcccaccag tgatgcgtct tgtttgtgcc aatagccatg tccatgagca gtcagtgctg 600 gtggcagcca cactggccat tgccatgcct ttcttcctca ttgccacttc ctacaccttc 660 attgtggctg ctgtgctcaa gattcactca acagctgggc gtcaccgggc cttctccacc 720 tgctcttccc acctctctgt ggtcctgctg cagtatggct gttgcgcctt catgtacctg 780 cgccccaact ccagctacta tcccaagcaa gatcagttca tctcactggt atacacattg 840 ggaaccccac tgctcaaccc acttatctac accctgagga acagtgaaat gaaggggacc 900 ttggggagag ttcttaccag gaattgcctc tcccagaaca actag 945 <210> 474 <211> 314 <212> PRT <213> Canis familiaris <400> 474

Met Thr Trp Gly Asn Arg Ser Leu Leu Met Glu Phe Gly Phe Leu Ala 1 5 10 15 Tyr Pro Ser His Pro Glu Leu Arg Val Leu Ser Phe Leu Gly Val Ser 20 25 30

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Leu Ile Tyr 35 Thr Leu Ile Ile Ser Gly Asn Val Leu Ile Val Val Ala 40 45 Ile Gln Thr Glu Ala Arg Leu His Thr Pro Met Tyr Tyr Phe Leu Gly 50 55 60 Ser Leu Ser Gly Ile Glu Ile Cys Tyr Thr Ala Val Val Val Pro His 65 70 75 80 Ile Leu Ala Asn Ile Leu Arg Pro Glu Lys Thr Ile Thr Leu Leu Gly 85 90 95 Cys Ala Thr Gln Met Ile Phe Phe Ile Gly Leu Gly Ser Ala Asp Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Gln Tyr Pro Leu Thr Met Thr Leu Thr Leu Cys Val Arg Leu 130 135 140 Val Met Ala Ser Val Val Ile Gly Leu Phe Leu Ser Thr Gln Leu Val 145 150 155 160 Ala Phe Ile Phe Ser Leu Pro Phe Cys Arg Ala Arg Ser Ile Glu His 165 170 175 Phe Phe Cys Asp Val Pro Pro Val Met Arg Leu Val Cys Ala Asn Ser 180 185 190 His Val His Glu Gln Ser Val Leu Val Ala Ala Thr Leu Ala Ile Ala 195 200 205 Met Pro Phe Phe Leu Ile Ala Thr Ser Tyr Thr Phe Ile Val Ala Ala 210 215 220 Val Leu Lys Ile His Ser Thr Ala Gly Arg His Arg Ala Phe Ser Thr 225 230 235 240

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Cys Ser Ser His Leu 245 Ser Phe Met Tyr Leu 260 Arg Pro Phe Ile Ser 275 Leu Val Tyr Ile Tyr 290 Thr Leu Arg Asn Leu 305 Thr Arg Asn Cys Leu 310

Val Val Leu Leu 250 Gln Asn Ser Ser 265 Tyr Tyr Thr Leu 280 Gly Thr Pro Ser 295 Glu Met Lys Gly Ser Gln Asn Asn

Tyr Gly Cys Cys 255 Ala Pro Lys Gln 270 Asp Gln Leu Leu 285 Asn Pro Leu Thr Leu Gly Arg Val

300 <210> 475 <211> 960 <212> DNA <213> Canis familiaris <400> 475 atgttcgcta ggagccctgt ttgaccaccg tcccagaatt atgatcctct gtggcaacac acccccatgt acttcttcct gtggtgcctc tgatgctttc tgtggggccc agatgttctt atcatggcct acgatcgcta acccagaagc tgtgcgccca ctgcagctca cgtccttaat cacttcctgt gcgatgtgcc caggcggtcc tctacgtggt gtgtcctatg tgttcatcgc cctcaaccaa tccggccccc ccaggccctg ctcttcctcc agccatcatc tgggtggtgt ctgcaacctg gccttcctgg caacatttgg ggagccccga ttttgtcacc ctcggcagca tgtggccatc tgccacccgc gatggtggcg tgcgcggtgg cttcaccctg cccttctgcg cccggtcctg cggctggcct gggcatcctc gtgctgaccg ctcggccatc ctgcgcatcc ctgagttctt cttccgcgtg tcttcctcct cctctacttg gcacgcacag ctccctccgc aaatctgcta caccacggtg agcccatccc cctggctggc ctgactgctt tctcttggca tgcactacac cctcatcatg gcctggccct ggtcctctcc ggcaccgccg ggagatcaac gcgccgacat ccgcgtgcac tccccttcct gctcatctgt gctccgccga gggccgccgc

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069269_0225_SL.TXT cgggccttct ccacctgctc ctcgcacctc accgtggtcc tgctgcagta cggctgttgc agcctcgtct acctgcggcc ccgctccagc tcctcggtgg acgaggaccg ccagatcgcc ctggtctaca ccttcgtcac ccccctcctc aacccgctga tttacaccct caggaacaag gatgtcaaag gtgccctgag gaatgccgtc ctccataaag cagcctctgg tgccagttga

780

840

900

960 <210> 476 <211> 319 <212> PRT <213> Canis familiaris <400> 476

Met Phe Ala Arg Ser Pro Val Leu Asn Gln Ser Gly Pro Pro Glu Phe 1 5 10 15 Phe Phe Arg Val Leu Thr Thr Val Pro Glu Phe Gln Ala Leu Leu Phe 20 25 30 Leu Leu Phe Leu Leu Leu Tyr Leu Met Ile Leu Cys Gly Asn Thr Ala 35 40 45 Ile Ile Trp Val Val Cys Thr His Ser Ser Leu Arg Thr Pro Met Tyr 50 55 60 Phe Phe Leu Cys Asn Leu Ala Phe Leu Glu Ile Cys Tyr Thr Thr Val 65 70 75 80 Val Val Pro Leu Met Leu Ser Asn Ile Trp Gly Ala Pro Lys Pro Ile 85 90 95 Pro Leu Ala Gly Cys Gly Ala Gln Met Phe Phe Phe Val Thr Leu Gly 100 105 110 Ser Thr Asp Cys Phe Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu His Tyr Thr Leu Ile Met Thr Gln Lys Leu 130 135 140 Cys Ala Gln Met Val Ala Cys Ala Val Gly Leu Ala Leu Val Leu Ser

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0 6926 9_02 25_S L.TX T 145 150 155 160 Leu Gln Leu Thr Ser Leu Ile Phe Thr Leu Pro Phe Cys Gly His Arg 165 170 175 Arg Glu Ile Asn His Phe Leu Cys Asp Val Pro Pro Val Leu Arg Leu 180 185 190 Ala Cys Ala Asp Ile Arg Val His Gln Ala Val Leu Tyr Val Val Gly 195 200 205 Ile Leu Val Leu Thr Val Pro Phe Leu Leu Ile Cys Val Ser Tyr Val 210 215 220 Phe Ile Ala Ser Ala Ile Leu Arg Ile Arg Ser Ala Glu Gly Arg Arg 225 230 235 240 Arg Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Leu Leu Gln 245 250 255 Tyr Gly Cys Cys Ser Leu Val Tyr Leu Arg Pro Arg Ser Ser Ser Ser 260 265 270 Val Asp Glu Asp Arg Gln Ile Ala Leu Val Tyr Thr Phe Val Thr Pro 275 280 285 Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly 290 295 300 Ala Leu Arg Asn Ala Val Leu His Lys Ala Ala Ser Gly Ala Ser 305 310 315

<210> 477 <211> 924 <212> DNA <213> Canis familiaris <400> 477 atgcatcaag gaaatcgaac caccatctct gggttcctcc ttctgggact ctccagccag 60 gctgagcacc aaaagcttct ctttgtgctt ttcctaggta tgtacctggt cactgtggtc 120

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gggaatgggc tcatcattct ggccattggc ttggattctt accttcacac tcccatgtat 180 cttttccttg ccaatctgtc ctttgctgat atttcctcca tatccacctc agtcccctag 240 atgctgatga atattcagac caaaactcaa tctatctcct atgaaagttg catcacacag 300 atgtactttt ctattgtgtt tgttgttaat gacaatttcc tctgaggagt catggcctat 360 gaccgctttg tggctatctg ccaccctctg aactatgtga ccctcatgca acccagaatc 420 tgcgttttgc tcacagtcat tccgtgggtc ctcagtaacg tggtcgccct aacacacacc 480 cttctgctca ttccattgct cttctgtgac agcaacattc tcccacactt cttctgtgac 540 ttggctcctc tgctcaaact gtcctgctca gacacaagta tcaatgaact catgttgttt 600 atcgtgggct catcagttgt caccttcccc tttgccttaa ttctcttctc ctacatctgc 660 attgtcaagg ctatcctgag aatctcatcc atggagggaa aacggaaagc cttcaccacc 720 tgtggctctc atttgactgt tgtattactc ttctatggga ccattatagg ggtttacttc 780 ttcccctcat ccactcaccc tgatgacaga gataagattg gtgcagtgct cttcactgtg 840 gtgacaccca tgataaaccc cttcatctat agcctgagga acaaggacat gaaagttgcc 900 ctaagaaagc tcattaatag aaaa 924

<210> 478 <211> 191 <212> PRT <213> Canis familiaris <400> 478

Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu Asn Tyr Val 1 5 10 15 Thr Leu Met Gln Pro Arg Ile Cys Val Leu Leu Thr Val Ile Pro Trp 20 25 30 Val Leu Ser Asn Val Val Ala Leu Thr His Thr Leu Leu Leu Ile Pro 35 40 45 Leu Leu Phe Cys Asp Ser Asn Ile Leu Pro His Phe Phe Cys Asp Leu 50 55 60

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Ala 65 Pro Leu Leu Lys Leu Ser 70 Cys Ser Asp Thr Ser Ile Asn Glu Leu 75 80 Met Leu Phe Ile Val Gly Ser Ser Val Val Thr Phe Pro Phe Ala Leu 85 90 95 Ile Leu Phe Ser Tyr Ile Cys Ile Val Lys Ala Ile Leu Arg Ile Ser 100 105 110 Ser Met Glu Gly Lys Arg Lys Ala Phe Thr Thr Cys Gly Ser His Leu 115 120 125 Thr Val Val Leu Leu Phe Tyr Gly Thr Ile Ile Gly Val Tyr Phe Phe 130 135 140 Pro Ser Ser Thr His Pro Asp Asp Arg Asp Lys Ile Gly Ala Val Leu 145 150 155 160 Phe Thr Val Val Thr Pro Met Ile Asn Pro Phe Ile Tyr Ser Leu Arg 165 170 175 Asn Lys Asp Met Lys Val Ala Leu Arg Lys Leu Ile Asn Arg Lys 180 185 190

<210> 479 <211> 945 <212> DNA <213> Canis familiaris <400> 479

atggccagga ggaaccacac catcgtgacc gagttcttcc tcactgcatt cagcgagcat 60 cctgagtggg ggcttcctct cttcctgctg tttttgggtt tttatgtcat caccttgttg 120 gggaacgcgg ggatggtcct tctgatccga gtggatggcc ggctgcacac cccgatgtac 180 ttcctcctcg gccacctgtc cttcgtggac atctgctact cgtccaccat cgtgccgcag 240 atgctggcgg tgctgctgca gcggggggca gcgctgtcct acacctgctg cgccgctcag 300 ttcttcctct tcaccttctt tgcttccatc gactgctacc tgctggctct catggcctat 360 gaccgctacg tggccgtgtg ccggcccctg ctgtatgtca ccatcatgac cgagaaggcg 420

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cgctggggct tcgtggctgg ggcttatggg gctggtttct ccagcgcctt tgttcgaaca 480 atcacagcct tctccctctc cttctgcggg gacaacgaga ttgactttat tttctgtgac 540 cttccccctc tgttaaagct gacctgtggg gacagctaca cccaggaggt ggtcattgtt 600 gtgtttgcca tctttgtcat gcctatttgt gtggtggcga tcttggtgtc ctacctgttt 660 attgttgtgg ccatcatgag gatcccctct gcggggggcc gggccaagac cttctctacc 720 tgcgcctctc acctcacggc tgtgtccctc ttcttcggca ccctcatctt catgtacctg 780 cgaggtaacg aggaccagcc ctccgaggga gaccgagtgg tgtcagtgct ctacacagtg 840 gtgacccctc tgctgaaccc cttcatctat agtctgagga ataaggaagt gaaggaggcg 900 tttaggaaag ctctgaacag gccaaaggct tctggaagga cctag 945

<210> 480 <211> 314 <212> PRT <213> Canis familiaris <400> 480

Met Ala Arg Arg Asn His Thr Ile Val Thr Glu Phe Phe Leu Thr Ala 1 5 10 15 Phe Ser Glu His Pro Glu Trp Gly Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 Gly Phe Tyr Val Ile Thr Leu Leu Gly Asn Ala Gly Met Val Leu Leu 35 40 45 Ile Arg Val Asp Gly Arg Leu His Thr Pro Met Tyr Phe Leu Leu Gly 50 55 60 His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Thr Ile Val Pro Gln 65 70 75 80 Met Leu Ala Val Leu Leu Gln Arg Gly Ala Ala Leu Ser Tyr Thr Cys 85 90 95 Cys Ala Ala Gln Phe Phe Leu Phe Thr Phe Phe Ala Ser Ile Asp Cys 100 105 110

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Tyr Leu Leu 115 Ala Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Arg 120 125 Pro Leu Leu Tyr Val Thr Ile Met Thr Glu Lys Ala Arg Trp Gly Phe 130 135 140 Val Ala Gly Ala Tyr Gly Ala Gly Phe Ser Ser Ala Phe Val Arg Thr 145 150 155 160 Ile Thr Ala Phe Ser Leu Ser Phe Cys Gly Asp Asn Glu Ile Asp Phe 165 170 175 Ile Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Thr Cys Gly Asp Ser 180 185 190 Tyr Thr Gln Glu Val Val Ile Val Val Phe Ala Ile Phe Val Met Pro 195 200 205 Ile Cys Val Val Ala Ile Leu Val Ser Tyr Leu Phe Ile Val Val Ala 210 215 220 Ile Met Arg Ile Pro Ser Ala Gly Gly Arg Ala Lys Thr Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Phe Gly Thr Leu Ile 245 250 255 Phe Met Tyr Leu Arg Gly Asn Glu Asp Gln Pro Ser Glu Gly Asp Arg 260 265 270 Val Val Ser Val Leu Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Phe Arg Lys Ala 290 295 300 Leu Asn Arg Pro Lys Ala Ser Gly Arg Thr 305 310

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069269_0225_SL.TXT <210> 481 <211> 936 <212> DNA <213> Canis familiaris <400> 481

atggcagaga agaatgtcac cttggtgagc gaattcctcc ttattgcatt taccgactgt 60 cctgagtggg gacttcctct cttcctcctg tttctatcca tttatgtcat cagcctgctg 120 gggaacgcgg ggatggtcct tctgatccga gtggatggcc ggctgcacac cccgatgtac 180 ttcctcctcg gccacctgtc cttcgtggac atctgctact cgtccaccat tgtgccgcag 240 atgctggcgg tgctgctgca gcggggggca gcgttgtcct acacctgctg cgctgctcag 300 ttcttcctct tcaccttctt tggctccatt gactgctacc tgctggccct catggcctat 360 gaccgctacg tggccgtgtg ccggcccctg ctgtatgtca ccatcatgac cgagaaggcg 420 cgctgggggt tcgtggctgg ggcttatggg gctggtttct ccagtgcctt tgttcgaaca 480 atcacagcct tctccctctc cttctgcggg gacaacgaga ttgactttat tttctgtgac 540 cttcctcctc tgttaaagct gacctgtggg gacagctata cccaggaggt ggtcattgtt 600 gtgtttgcca tctttgtcat ccctgcctgc atggtggcga tcttggtgtc ctacctgttt 660 attgttgtgg ccatcatgag gatcccctca gctggaggcc gggccaagac cttctctacc 720 tgcgcctctc acctcacgac tgtgtccctc ttcttcggca ccctcatctt catgtacctc 780 agagataact ctggccactc ttcacaggag gatcgggtgg tgtctgtgtt ctacacaaca 840 gtgatcccca tgttgaaccc cctcatttat agcatgagga ataaggaagt gaaggaggcc 900 ctgaggaaag ttctcaaaag agctgagttg tactga 936

<210> 482 <211> 311 <212> PRT <213> Canis familiaris <400> 482

Met Ala Glu Lys Asn Val Thr Leu Val Ser Glu Phe Leu Leu Ile Ala 1 5 10 15

Phe Thr Asp Cys Pro Glu Trp Gly Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30

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Ser Ile Tyr 35 Val Ile Ser Leu Leu Gly Asn Ala Gly Met Val Leu Leu 40 45 Ile Arg Val Asp Gly Arg Leu His Thr Pro Met Tyr Phe Leu Leu Gly 50 55 60 His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Thr Ile Val Pro Gln 65 70 75 80 Met Leu Ala Val Leu Leu Gln Arg Gly Ala Ala Leu Ser Tyr Thr Cys 85 90 95 Cys Ala Ala Gln Phe Phe Leu Phe Thr Phe Phe Gly Ser Ile Asp Cys 100 105 110 Tyr Leu Leu Ala Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Arg 115 120 125 Pro Leu Leu Tyr Val Thr Ile Met Thr Glu Lys Ala Arg Trp Gly Phe 130 135 140 Val Ala Gly Ala Tyr Gly Ala Gly Phe Ser Ser Ala Phe Val Arg Thr 145 150 155 160 Ile Thr Ala Phe Ser Leu Ser Phe Cys Gly Asp Asn Glu Ile Asp Phe 165 170 175 Ile Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Thr Cys Gly Asp Ser 180 185 190 Tyr Thr Gln Glu Val Val Ile Val Val Phe Ala Ile Phe Val Ile Pro 195 200 205 Ala Cys Met Val Ala Ile Leu Val Ser Tyr Leu Phe Ile Val Val Ala 210 215 220 Ile Met Arg Ile Pro Ser Ala Gly Gly Arg Ala Lys Thr Phe Ser Thr 225 230 235 240

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Cys Ala Ser His Leu Thr Thr Val Ser Leu Phe Phe Gly Thr Leu Ile 245 250 255 Phe Met Tyr Leu Arg Asp Asn Ser Gly His Ser Ser Gln Glu Asp Arg 260 265 270 Val Val Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Met Arg Asn Lys Glu Val Lys Glu Ala Leu Arg Lys Val 290 295 300 Leu Lys Arg Ala Glu Leu Tyr

305 310 <210> 483 <211> 942 <212> DNA <213> Canis familiaris <400> 483

atggagaaga atggcaccat ggtgacggaa ttcattctgc tggggttcca gctgccggca 60 gagctgcaga tgggtctctt ccttgtgttt ctggtccttt atttcattac cttggtgggc 120 aacctgggca tgatcgtgtt gattcagaga gaccctcgtc tccaaacccc catgtacttc 180 ttcctctgcc atctttcctt cttggatatt tgctattcct ctgtcattgt ccctcagttt 240 cttgaaacct tgggtaccga taagatggcc atcacctatg agtgctgtgc cactcagttc 300 ttcttcttta ccctctgtgc tagcactgaa tgtttccttt tggctgtgat ggcctatgac 360 cgctatgtgg cggtgtgtaa ccccctcctc tatgccactg ccatgacacc acagacttgc 420 ctggggctgg tgactggggc atatgctggt gccatggtca atgctgtgat ccgcactggg 480 tgtaccttct ctatctcttt ctgtaagtcc aaccacgtgg acttcttctt ttgtgacctc 540 ccacccctgc tgaagcttgc ctgtagtgac accaagttac gggaacgggt catttacctc 600 ttagctttct tggtcattac aaccagtatt tcagtgattc ttatatccta ctttttcatc 660 attcaggcta ttctgaagat tcgtacagca ggtggcaaag ccaagacttt ctccacctgt 720

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069269_0225_SL.TXT gcttctcaca tgaccgcagt agctcttttc tttgggacac tcatattcat atacctgaaa ggtaacatgg gaaagtccct tggggaggac aagattgtgt cagtatttta cactgtggtc atccctatgt tgaacccaat gatctatagc ttgagaaaca aggaagtgaa ggaggctctg aagaaagctt tcaatgggat gaaggtttcc caagcagact aa

780

840

900

942 <210> 484 <211> 313 <212> PRT <213> Canis familiaris <400> 484

Met Glu Lys Asn Gly Thr Met Val Thr Glu Phe Ile Leu Leu Gly Phe 1 5 10 15 Gln Leu Pro Ala Glu Leu Gln Met Gly Leu Phe Leu Val Phe Leu Val 20 25 30 Leu Tyr Phe Ile Thr Leu Val Gly Asn Leu Gly Met Ile Val Leu Ile 35 40 45 Gln Arg Asp Pro Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Cys His 50 55 60 Leu Ser Phe Leu Asp Ile Cys Tyr Ser Ser Val Ile Val Pro Gln Phe 65 70 75 80 Leu Glu Thr Leu Gly Thr Asp Lys Met Ala Ile Thr Tyr Glu Cys Cys 85 90 95 Ala Thr Gln Phe Phe Phe Phe Thr Leu Cys Ala Ser Thr Glu Cys Phe 100 105 110 Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asn Pro 115 120 125 Leu Leu Tyr Ala Thr Ala Met Thr Pro Gln Thr Cys Leu Gly Leu Val 130 135 140 Thr Gly Ala Tyr Ala Gly Ala Met Val Asn Ala Val Ile Arg Thr Gly

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145 150 155 160 Cys Thr Phe Ser Ile Ser Phe Cys Lys Ser Asn His Val Asp Phe Phe 165 170 175 Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ala Cys Ser Asp Thr Lys 180 185 190 Leu Arg Glu Arg Val Ile Tyr Leu Leu Ala Phe Leu Val Ile Thr Thr 195 200 205 Ser Ile Ser Val Ile Leu Ile Ser Tyr Phe Phe Ile Ile Gln Ala Ile 210 215 220 Leu Lys Ile Arg Thr Ala Gly Gly Lys Ala Lys Thr Phe Ser Thr Cys 225 230 235 240 Ala Ser His Met Thr Ala Val Ala Leu Phe Phe Gly Thr Leu Ile Phe 245 250 255 Ile Tyr Leu Lys Gly Asn Met Gly Lys Ser Leu Gly Glu Asp Lys Ile 260 265 270 Val Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Met Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Lys Lys Ala Phe 290 295 300 Asn Gly Met Lys Val Ser Gln Ala Asp

305 310 <210> 485 <211> 945 <212> DNA <213> Canis familiaris <400> 485 atggccaaga ataatctcac cacagtagca gagttcattc tcatgggctt tacggactac 60 cacatgtggg agattaccct cttcctgatg tttctcattt tctatattgt cacccttctg 120

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069269_0225_SL.TXT gggaacgtgg gaatgatcat tctgatccaa gtggatgtcc aactccacac ccccatgtac ttcttcctga gccatctcgc cctgctggat gcctgctatg cctcagtgat cacccctcag atcctggaca cactggccac aggcaaaaca gtcatctcct ttggccagtg tgctacgcag ttctttttct tcaccatctg tgcaggcaca gagtgtttcc tgctggcagt gatggcctat gaccgctgtg tcgctattag caacccactg ctctacacag tggtcatgaa tcccagaatc tgctggggtt tggtggttgg agcctacgtc tgtggggtgt caggagccat cctgcgtacc acatgcacct tcaccctctc cttctgtgac cacaatcaga tcaacttctt cttctgtgat gtcccacccc tgttgaagct agcctgcagt gacacaacaa acacggagat tgtcattgtc ttctttggca actttgtgat cttggccaat gccttggtca ttctgatatc ctatctgctc atcatcaagg ccattctgaa ggtgaagtct ccaggtggca aggtcaagac tttctccaca tgtgcctccc acctcactgc tgtgaccctt ttctttggga ctctcatctt catgtatctg cggagtagct ccaacaagtc cctggaggaa gacaaggtcg tgtctgtctt ctacactgtg ttcattccca tgctaaaccc tctgatctat agcctaagaa acaaagatgt gaaagcagcc ttcagaaagg tcactggtag attccaggtg tcccagagtg tgtag <210> 486 <211> 314 <212> PRT <213> Canis familiaris

180

240

300

360

420

480

540

600

660

720

780

840

900

945 <400> 486

Met Ala Lys Asn Asn Leu Thr Thr Val Ala Glu Phe Ile Leu Met Gly 1 5 10 15 Phe Thr Asp Tyr His Met Trp Glu Ile Thr Leu Phe Leu Met Phe Leu 20 25 30 Ile Phe Tyr Ile Val Thr Leu Leu Gly Asn Val Gly Met Ile Ile Leu 35 40 45 Ile Gln Val Asp Val Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60

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His 65 Leu Ala Leu Leu Asp Ala Cys Tyr Ala Ser Val Ile Thr Pro Gln 70 75 80 Ile Leu Asp Thr Leu Ala Thr Gly Lys Thr Val Ile Ser Phe Gly Gln 85 90 95 Cys Ala Thr Gln Phe Phe Phe Phe Thr Ile Cys Ala Gly Thr Glu Cys 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Cys Val Ala Ile Ser Asn 115 120 125 Pro Leu Leu Tyr Thr Val Val Met Asn Pro Arg Ile Cys Trp Gly Leu 130 135 140 Val Val Gly Ala Tyr Val Cys Gly Val Ser Gly Ala Ile Leu Arg Thr 145 150 155 160 Thr Cys Thr Phe Thr Leu Ser Phe Cys Asp His Asn Gln Ile Asn Phe 165 170 175 Phe Phe Cys Asp Val Pro Pro Leu Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 Thr Asn Thr Glu Ile Val Ile Val Phe Phe Gly Asn Phe Val Ile Leu 195 200 205 Ala Asn Ala Leu Val Ile Leu Ile Ser Tyr Leu Leu Ile Ile Lys Ala 210 215 220 Ile Leu Lys Val Lys Ser Pro Gly Gly Lys Val Lys Thr Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Val Thr Leu Phe Phe Gly Thr Leu Ile 245 250 255 Phe Met Tyr Leu Arg Ser Ser Ser Asn Lys Ser Leu Glu Glu Asp Lys 260 265 270

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Val Val Ser Val Phe Tyr Thr Val Phe Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala Phe Arg Lys Val 290 295 300 Thr Gly Arg Phe Gln Val Ser Gln Ser Val 305 310

<210> 487 <211> 900 <212> DNA <213> Canis familiaris <400> 487

aataatctca ctgctgtgat ggagttcatc cttgtgggct tcacagatca ccctgaactg 60 atgattcccc tcttcctgat gtttctcatt ttctatatca tcacccttct ggggaatgtg 120 ggaattatca ttctgatcca agtggatgtc caactccaca cccccccatg tacttcttcc 180 tgagccatct cgccctgctg gatgcctgct atgcctcagt gatcacccct cagatcctgg 240 acagacacac tggccacagg caagatagtc atctcctttg gtcaatgtgc tatgcggtct 300 tttcttcacc atctttgcag gcacagagtg tttcctgctg gcagtgatgg tctatgacca 360 ctttgttgcc atcagcaact cattgcatat aacctggcca tgactccagg cacctgcagg 420 ggatccttgg ctgcagccta tgtctatggg gtatcagggg acatcctgca taccacatgc 480 accttcaccc tctccttctg tgaccacaat cagttcaact tcttctgtga cttcccatcc 540 ctgctgaagc ttgcctggaa cagcatgaca taaaatgtga ttgtcatcct cttttttgcc 600 aagttcatgt tccttgccaa tgtcatgatc atcatggcgt cctatatgct cataatcaga 660 gccatcctga gggtgaggtc tgctggtggg agagccaaga tcatctccac atatgcctcc 720 cacctcacca ctgttgtcct cttcttcggg acacttgcct tcatgtacca gagaagtaac 780 tcagaccaat tcccagagga gaagattgtg tctgtctttt accccatggt catccccctg 840 ttgaacccct tgatctacag cctgaggaac aaagatgtaa aagctacatt caggaaagtc 900

<210> 488 <211> 98 <212> PRT

Page 542

069269_0225_SL.TXT <213> Canis familiaris <400> 488

Met 1 Phe Leu Ala Asn Val Met Ile Ile Met Ala Ser Tyr Met Leu 15 Ile 5 10 Ile Arg Ala Ile Leu Arg Val Arg Ser Ala Gly Gly Arg Ala Lys Ile 20 25 30 Ile Ser Thr Tyr Ala Ser His Leu Thr Thr Val Val Leu Phe Phe Gly 35 40 45 Thr Leu Ala Phe Met Tyr Gln Arg Ser Asn Ser Asp Gln Phe Pro Glu 50 55 60 Glu Lys Ile Val Ser Val Phe Tyr Pro Met Val Ile Pro Leu Leu Asn 65 70 75 80 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Thr Phe Arg 85 90 95

Lys Val <210> 489 <211> 939 <212> DNA <213> Canis familiaris <400> 489

atgggggatg aaaaccaaac catagacatc cagttccact ttcatccatt ttcacccatc 60 ctggagatac aaatacttat ttttgtggct ttcctgctaa tgtatattgg cagtctcact 120 ggtaatgcca caatctttct cactgtctgg gcagagcgtt cactccacac tcccatgtat 180 ttctttctgg ccaatctggc agttctggag atcttttact cttccactgt tgcccctctc 240 gctttggtca acctcctgac catggggaga atacccatct ctttcgctgg ctgtggcaca 300 cagatgttct tttttgtctt tctgggcagt gctgactgta tcctcttggg gatcatggct 360 tatgatcggt ttgtagctat tcggaagcct ctgcgttaca ccctcatcat gagatggcag 420 ctgtgtgccc agctggctct gggagccctg gtccttggtt tcattctagc cttacaacta 480

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acagctctga ttttccatct gccattttgt ggccacaaca gaatcactca cttctactgt 540 gatgtactcc cgatcttgca gctggcctgt ggggatactc gaatgcaaga agccatgatc 600 ttcattgtca gtgtcatcat cctcaccatt cccttttctc tgatctccat ctcatacgtc 660 ttcattgtgg gtgccattct gaagatccgc tctgcagagg ggcggcacaa ggccttctcc 720 acctgttctt ctcacctgac tgtagttctc ctccagtatg gctgctgtag ccttatctat 780 ttacgcccca gctctagcta caacccagaa atgggccgtg tggtgtctgt tgtctacact 840 tttgtcaccc ctgtcttgaa ccccttgatc tacagtatga ggaacaagga gctgaaagat 900 gcattaaata aggtaatgaa aagacatctg ctccactag 939

<210> 490 <211> 312 <212> PRT <213> Canis familiaris <400> 490

Met Gly Asp Glu Asn Gln Thr Ile Asp Ile Gln Phe His Phe His Pro 1 5 10 15 Phe Ser Pro Ile Leu Glu Ile Gln Ile Leu Ile Phe Val Ala Phe Leu 20 25 30 Leu Met Tyr Ile Gly Ser Leu Thr Gly Asn Ala Thr Ile Phe Leu Thr 35 40 45 Val Trp Ala Glu Arg Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ala Val Leu Glu Ile Phe Tyr Ser Ser Thr Val Ala Pro Leu 65 70 75 80 Ala Leu Val Asn Leu Leu Thr Met Gly Arg Ile Pro Ile Ser Phe Ala 85 90 95 Gly Cys Gly Thr Gln Met Phe Phe Phe Val Phe Leu Gly Ser Ala Asp 100 105 110

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Cys Ile Leu 115 Leu Gly Ile Met 069269_0225_SL.TXT Ala Tyr Asp Arg Phe Val 120 125 Ala Ile Arg Lys Pro Leu Arg Tyr Thr Leu Ile Met Arg Trp Gln Leu Cys Ala Gln 130 135 140 Leu Ala Leu Gly Ala Leu Val Leu Gly Phe Ile Leu Ala Leu Gln Leu 145 150 155 160 Thr Ala Leu Ile Phe His Leu Pro Phe Cys Gly His Asn Arg Ile Thr 165 170 175 His Phe Tyr Cys Asp Val Leu Pro Ile Leu Gln Leu Ala Cys Gly Asp 180 185 190 Thr Arg Met Gln Glu Ala Met Ile Phe Ile Val Ser Val Ile Ile Leu 195 200 205 Thr Ile Pro Phe Ser Leu Ile Ser Ile Ser Tyr Val Phe Ile Val Gly 210 215 220 Ala Ile Leu Lys Ile Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ser His Leu Thr Val Val Leu Leu Gln Tyr Gly Cys Cys 245 250 255 Ser Leu Ile Tyr Leu Arg Pro Ser Ser Ser Tyr Asn Pro Glu Met Gly 260 265 270 Arg Val Val Ser Val Val Tyr Thr Phe Val Thr Pro Val Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Met Arg Asn Lys Glu Leu Lys Asp Ala Leu Asn Lys 290 295 300 Val Met Lys Arg His Leu Leu His

305 310

Page 545

069269_0225_SL.TXT <210> 491 <211> 954 <212> DNA <213> Canis familiaris <400> 491

atgcagccat atgcccaaaa ctggacccat gtaacagagt ttgtcatggt gggctttgct 60 ggggtgcatg aagcacgcct tctcttcttt acagtctttc tcaccatgta cctgttcacc 120 ttggtggaga acttggccat catcttggtg gtggctttga accatcggct acacagaccc 180 atgtatttct tcctgacaca cttgtcctgc cttgaaattt ggtacacttc agtgacggtg 240 cctaagatgc tggctggttt tattggggta gatgggggca agaatatctc ctacactggc 300 tgtctatccc aactcttcat ctttaccttc ctgggggcaa ctgagtgttt tctactggct 360 gccatggcct atgaccgcta tgtggccatt tgtatgcctc ttcgatatgg ggccttggtg 420 tcgtggggca cctgcatccg tctggcagct gcttgttggc tggtgggcct cctcacacct 480 gttttgccta tctacctcat gtcccagctg acattttgtg gtcccaatgt catcgaccac 540 ttcttctgtg atgtctcacc actgctagcc ttgtcctgct cagatgtcac cctgaaggag 600 accacagact tcctagtctc tctgatggtg ctcctggtct cctctacagt catttctgtg 660 tcctatggca acatcgtctg gacgttgctg cacatccgtt cggctgctga gcgcagaaag 720 gctttctcca cttgtgcagc tcacctgaca gtggtgagcc tcttctatgg cactcttttc 780 tttatgtatg tccggaccaa agtggcctcc tccatcaact tcaacaaggt agtgtctgtc 840 ttctactcca ttgtcacacc aatgctcaac cccctcatct acagtcttcg gaacaaggag 900 gtgaagggag ctctgggccg agccttttcc ctcaggtctt ggaaaggtca gtga 954

<210> 492 <211> 317 <212> PRT <213> Canis familiaris <400> 492

Met Gln Pro Tyr Ala Gln Asn Trp Thr His Val Thr Glu Phe Val Met 1 5 10 15

Val Gly Phe Ala Gly Val His Glu Ala Arg Leu Leu Phe Phe Thr Val 20 25 30

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Phe Leu Thr 35 Met Tyr Leu Phe Thr Leu Val Glu Asn Leu Ala Ile Ile 40 45 Leu Val Val Ala Leu Asn His Arg Leu His Arg Pro Met Tyr Phe Phe 50 55 60 Leu Thr His Leu Ser Cys Leu Glu Ile Trp Tyr Thr Ser Val Thr Val 65 70 75 80 Pro Lys Met Leu Ala Gly Phe Ile Gly Val Asp Gly Gly Lys Asn Ile 85 90 95 Ser Tyr Thr Gly Cys Leu Ser Gln Leu Phe Ile Phe Thr Phe Leu Gly 100 105 110 Ala Thr Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys Met Pro Leu Arg Tyr Gly Ala Leu Val Ser Trp Gly Thr 130 135 140 Cys Ile Arg Leu Ala Ala Ala Cys Trp Leu Val Gly Leu Leu Thr Pro 145 150 155 160 Val Leu Pro Ile Tyr Leu Met Ser Gln Leu Thr Phe Cys Gly Pro Asn 165 170 175 Val Ile Asp His Phe Phe Cys Asp Val Ser Pro Leu Leu Ala Leu Ser 180 185 190 Cys Ser Asp Val Thr Leu Lys Glu Thr Thr Asp Phe Leu Val Ser Leu 195 200 205 Met Val Leu Leu Val Ser Ser Thr Val Ile Ser Val Ser Tyr Gly Asn 210 215 220 Ile Val Trp Thr Leu Leu His Ile Arg Ser Ala Ala Glu Arg Arg Lys 225 230 235 240

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Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ser Leu Phe Tyr 245 250 255 Gly Thr Leu Phe Phe Met Tyr Val Arg Thr Lys Val Ala Ser Ser Ile 260 265 270 Asn Phe Asn Lys Val Val Ser Val Phe Tyr Ser Ile Val Thr Pro Met 275 280 285 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala 290 295 300 Leu Gly Arg Ala Phe Ser Leu Arg Ser Trp Lys Gly Gln 305 310 315

<210> 493 <211> 888 <212> DNA <213> Canis familiaris <400> 493

atgacgctgg ggcagaacca caccacagtg acaagattca tcctgctggg cctcacagac 60 caggcccccg gaagacatct cctcttcggc atcttcctgc taatctatgc tgtgaccctg 120 gtgggcaacc tgggcatgat ggacctgatc cgtaccagct ccaccctcca cacccccatg 180 tacttcctcc tgagcgtgct ctccttcctg gatatatgca attcctctgt gttcaccccc 240 aggctgctga tcagcttcct caccacggac cagtccatct cgtttgcggg ctgtgtggtc 300 cagatggcct tcatgatcct ccatggcaca ggggagtgcc tgctcttggc cttcatggcc 360 tatgaccgat ttgtggccat ctgccaccct ctcctctacc atacgatcat gtccaagcgc 420 ttgtgcatcc agctggcggt ggtcacctat gcggcagggg tgttcatttc agctctgcag 480 acggggaatg ccttcatctt gccctactgt ggtcccaaca tcattgatca cttcttctgt 540 gacatccccc ccgtgctcca actggcctgc tcagacacca ccgtagccaa tatcatcctg 600 ctcttccttt ctgccttggt tactgtcccc acggtgtcag ccatcttagt ctcttatacc 660 tacatcctgg tcacaatctg taggatgagg tccctggagg cccagcgcaa agctttctcc 720 acttgtgcct cccacctcat tgccctctcc ctcttctatg ggtctgtgtt ctttgtctat 780

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069269_0225_SL.TXT gtccaaccca acccagaaag tgcctcagcc tataataaga ccctgtctgt gttctacacc attgtgatcc ccatgctgaa ccccctggtc tacagcctaa ggaaataa

840

888 <210> 494 <211> 295 <212> PRT <213> Canis familiaris <400> 494

Met Thr 1 Leu Gly Gln Asn His Thr Thr Val Thr Arg Phe Ile Leu Leu 5 10 15 Gly Leu Thr Asp Gln Ala Pro Gly Arg His Leu Leu Phe Gly Ile Phe 20 25 30 Leu Leu Ile Tyr Ala Val Thr Leu Val Gly Asn Leu Gly Met Met Asp 35 40 45 Leu Ile Arg Thr Ser Ser Thr Leu His Thr Pro Met Tyr Phe Leu Leu 50 55 60 Ser Val Leu Ser Phe Leu Asp Ile Cys Asn Ser Ser Val Phe Thr Pro 65 70 75 80 Arg Leu Leu Ile Ser Phe Leu Thr Thr Asp Gln Ser Ile Ser Phe Ala 85 90 95 Gly Cys Val Val Gln Met Ala Phe Met Ile Leu His Gly Thr Gly Glu 100 105 110 Cys Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Phe Val Ala Ile Cys 115 120 125 His Pro Leu Leu Tyr His Thr Ile Met Ser Lys Arg Leu Cys Ile Gln 130 135 140 Leu Ala Val Val Thr Tyr Ala Ala Gly Val Phe Ile Ser Ala Leu Gln 145 150 155 160

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Thr Gly Asn Ala Phe Ile Leu Pro Tyr Cys Gly Pro Asn Ile Ile Asp 165 170 175 His Phe Phe Cys Asp Ile Pro Pro Val Leu Gln Leu Ala Cys Ser Asp 180 185 190 Thr Thr Val Ala Asn Ile Ile Leu Leu Phe Leu Ser Ala Leu Val Thr 195 200 205 Val Pro Thr Val Ser Ala Ile Leu Val Ser Tyr Thr Tyr Ile Leu Val 210 215 220 Thr Ile Cys Arg Met Arg Ser Leu Glu Ala Gln Arg Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Ile Ala Leu Ser Leu Phe Tyr Gly Ser Val 245 250 255 Phe Phe Val Tyr Val Gln Pro Asn Pro Glu Ser Ala Ser Ala Tyr Asn 260 265 270 Lys Thr Leu Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Val Tyr Ser Leu Arg Lys

290 295 <210> 495 <211> 960 <212> DNA <213> Canis familiaris <400> 495 atgacacctg gagaactagc ccttgcaagt ggcaaccaca ctccagttac ccagttcatc ttgttgggat tctccagcta tccagagctc cagcagcttc tatttgtaac ctttctgctc atttatgcca tgacagtgat gggcaacctg ggaatgatgg cactcatctt cacagactcc cgtctccata gtcccatgta tttcttcctc agtgtcctct cttttcttga tatttgttac tcttctgtgg tcacacccaa gctcttggtc aacttcctgg cctctgacaa gaccatttct

120

180

240

300

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tttgagggct gtgtggtcca gctaaccttt tttgtggtgc atgtgacagc tgagagcttc 360 ctgctggcct ccatggccta cgatcgcttt gtggccatct gccaacctct ccattatggt 420 tcgatcatga ccaaggagac ctgtctccag ctggtagctg cttcctatgc atttggtggc 480 gccaactctg ctatccagac tgggaacgtc tttgctctgc ctttctgtgg gcccaaccag 540 gtaacacact acttctgtga catccctccc cttctccgcc tggcttgtgc caacacagcc 600 acagcaggag tggtcctcta tatcttctct gctctggtta cccttctgcc tgctgcagtc 660 atcctcacct cctacagctt ggtcttggtg gccattggga ggatgcgctc ggccgctgga 720 cgggagaagg ccctctccac ctgtgcctcc cacttcctgg ccattgccat tttctacggc 780 actgtggttt tcacctatgt ccagcctcat ggatccacta atgataccaa tggccaaata 840 gtgtccgtgt tctacaccat cataatcccc atgctcaacc ccttcatcta tagcctccgc 900 aacaaagagg tgaaggacgc actacagaga aagctccagg tcagtatctt tccctgctga 960

<210> 496 <211> 319 <212> PRT <213> Canis familiaris <400> 496

Met Thr Pro Gly Glu Leu Ala Leu Ala Ser Gly Asn His Thr Pro Val 1 5 10 15 Thr Gln Phe Ile Leu Leu Gly Phe Ser Ser Tyr Pro Glu Leu Gln Gln 20 25 30 Leu Leu Phe Val Thr Phe Leu Leu Ile Tyr Ala Met Thr Val Met Gly 35 40 45 Asn Leu Gly Met Met Ala Leu Ile Phe Thr Asp Ser Arg Leu His Ser 50 55 60 Pro Met Tyr Phe Phe Leu Ser Val Leu Ser Phe Leu Asp Ile Cys Tyr 65 70 75 80 Ser Ser Val Val Thr Pro Lys Leu Leu Val Asn Phe Leu Ala Ser Asp 85 90 95

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Lys Thr Ile Ser 100 Phe Glu Gly Cys Val Val Gln Leu Thr Phe Phe Val 105 110 Val His Val Thr Ala Glu Ser Phe Leu Leu Ala Ser Met Ala Tyr Asp 115 120 125 Arg Phe Val Ala Ile Cys Gln Pro Leu His Tyr Gly Ser Ile Met Thr 130 135 140 Lys Glu Thr Cys Leu Gln Leu Val Ala Ala Ser Tyr Ala Phe Gly Gly 145 150 155 160 Ala Asn Ser Ala Ile Gln Thr Gly Asn Val Phe Ala Leu Pro Phe Cys 165 170 175 Gly Pro Asn Gln Val Thr His Tyr Phe Cys Asp Ile Pro Pro Leu Leu 180 185 190 Arg Leu Ala Cys Ala Asn Thr Ala Thr Ala Gly Val Val Leu Tyr Ile 195 200 205 Phe Ser Ala Leu Val Thr Leu Leu Pro Ala Ala Val Ile Leu Thr Ser 210 215 220 Tyr Ser Leu Val Leu Val Ala Ile Gly Arg Met Arg Ser Ala Ala Gly 225 230 235 240 Arg Glu Lys Ala Leu Ser Thr Cys Ala Ser His Phe Leu Ala Ile Ala 245 250 255 Ile Phe Tyr Gly Thr Val Val Phe Thr Tyr Val Gln Pro His Gly Ser 260 265 270 Thr Asn Asp Thr Asn Gly Gln Ile Val Ser Val Phe Tyr Thr Ile Ile 275 280 285 Ile Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Glu Val 290 295 300

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Lys Asp Ala Leu Gln Arg Lys Leu Gln Val Ser Ile Phe Pro Cys 305 310 315 <210> 497 <211> 936 <212> DNA <213> Canis familiaris <400> 497

atggaggagg gaaattatac cagagtgaaa gaatttattt ttcaaggact tacccagtct 60 cgagagctga gcttggtctt atttcttttt ttatttttgg tgtacacatc aactgtgatg 120 ggaaacctcc tcatcatggt cactgtgacc tgtgagtccc gccttcatac ccccatgtac 180 ttcctgctcc gcaacctctc agtcttggac atctgcttct cctccatcac tgctcccaag 240 gtccttgtgg accttctgtc aaggacaaag accatctcct tcaatggttg catcactcag 300 atgttcttct tccaccttct cggtggggca gacatttttt ctctctctgt gatggccttt 360 gaccgctaca tggccatctc caagcccttg cactacgtga ccatcatgag tagggggcga 420 tgcactgccc tcattgtggc ctcctgggtg gggggctttg ttcactccat cgtgcagatt 480 tccctgttgc tgcccctccc cttctgtggg cctaatgttg ttgatggctt ctactgcgat 540 gtcccccagg tcctcaaact tgcctgcact gacaccttgg ttcttgaggt cttaatgatt 600 tccaataatg gcttaatctc gacactatgg tttgtcttcc tcctcgtgtc ctacacagtc 660 attctgacga tgctgaggtc tcatgctggg gagggcagga ggaaagccat ctccacttgc 720 acttcccaca tcactgtggt gacccttcac tttgtgccct gtatctatgt ctatgcccgg 780 cccttcactg ccctccccat ggacagagct gtctccatca ccttcacagt catcatccct 840 gttctgaacc ccatgatcta caccctgagg aaccaggaga tgaagtcagc catgaggaga 900 cttaagagaa gacttggacc ttctaaaaaa gaatag 936

<210> 498 <211> 311 <212> PRT <213> Canis familiaris <400> 498

Met Glu Glu Gly Asn Tyr Thr Arg Val Lys Glu Phe Ile Phe Gln Gly 1 5 10 15

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Leu Thr Gln Ser 20 Arg Glu Leu Ser Leu Val Leu Phe Leu Phe Leu Phe 25 30 Leu Val Tyr Thr Ser Thr Val Met Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Thr Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ser Val Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Val Leu Val Asp Leu Leu Ser Arg Thr Lys Thr Ile Ser Phe Asn Gly 85 90 95 Cys Ile Thr Gln Met Phe Phe Phe His Leu Leu Gly Gly Ala Asp Ile 100 105 110 Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Met Ala Ile Ser Lys 115 120 125 Pro Leu His Tyr Val Thr Ile Met Ser Arg Gly Arg Cys Thr Ala Leu 130 135 140 Ile Val Ala Ser Trp Val Gly Gly Phe Val His Ser Ile Val Gln Ile 145 150 155 160 Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Val Asp Gly 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Asp Thr 180 185 190 Leu Val Leu Glu Val Leu Met Ile Ser Asn Asn Gly Leu Ile Ser Thr 195 200 205 Leu Trp Phe Val Phe Leu Leu Val Ser Tyr Thr Val Ile Leu Thr Met 210 215 220

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Leu Arg 225 Ser His Ala Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 230 235 240 Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Met Asp Arg Ala Val Ser 260 265 270 Ile Thr Phe Thr Val Ile Ile Pro Val Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Lys Ser Ala Met Arg Arg Leu Lys Arg Arg 290 295 300 Leu Gly Pro Ser Lys Lys Glu

305 310 <210> 499 <211> 936 <212> DNA <213> Canis familiaris <400> 499

atggatcagg gaaattatac gaaagtgaaa gaatttcttt tcctgggtat tactcagtct 60 cgagagctga gcttggtctt gtttgtcttc ttgtttacgg tgtatatgac aactctgctg 120 ggaaacctcc tcatcatggt cactgtgacc tttgagtctc accttcatac ccccatgtac 180 ttcctgctcc gcaacctctc tgtcttggac atctgcttct cctccatcac tgctcccaag 240 gtcctagttg atcttctatc aaaaagaaaa accatctcct tcaatggctg tgtcactcaa 300 atgtttttct tccaccttct gggaggagca gatgtttttt ctctctctgt gatggccttt 360 gatcgctacg tggccatctc aagacccctt cactatatga caatcatgag taaggaacga 420 tgtactagcc tggtgctggc ctcctgggtg gggggctttg tccactccat cgtgcagatt 480 tccctgttgc ttccactccc cttctgtgga cccaatgttc ttgacacttt ctactgcgat 540 gtcccccagg tcctcaagct cgcctgtaca gacaccatct ctctggagat cctgatgatt 600

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069269_0225_SL.TXT tctaataatg gattagtcag ttggcttatt ttcttctttc tcctcatatc ttacacggtc attctgatga tgctgaggtc tcatgctggg gagggaagga ggaaagccat ctccacctgc acctcccaca tcactgtggt aaccttacac tttgtgccct gtatctatgt ctatgcccgg ccctttactg ccctccccac agataaagcc atctctgtca ccttcacggt catctcccct ttgctcaatc ctatgatcta caccctgagg aaccaggaaa tgaagtcagc catgaggaga ttaaagaaac gactagggca ttcagaaagg atttaa

660

720

780

840

900

936 <210> 500 <211> 311 <212> PRT <213> Canis familiaris <400> 500

Met 1 Asp Gln Gly Asn Tyr Thr Lys Val Lys Glu Phe Leu Phe Leu Gly 5 10 15 Ile Thr Gln Ser Arg Glu Leu Ser Leu Val Leu Phe Val Phe Leu Phe 20 25 30 Thr Val Tyr Met Thr Thr Leu Leu Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Thr Phe Glu Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ser Val Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Val Leu Val Asp Leu Leu Ser Lys Arg Lys Thr Ile Ser Phe Asn Gly 85 90 95 Cys Val Thr Gln Met Phe Phe Phe His Leu Leu Gly Gly Ala Asp Val 100 105 110 Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Val Ala Ile Ser Arg 115 120 125 Pro Leu His Tyr Met Thr Ile Met Ser Lys Glu Arg Cys Thr Ser Leu

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130 135 069269_0225_SL.TXT 140 Val Leu Ala Ser Trp Val Gly Gly Phe Val His Ser Ile Val Gln Ile 145 150 155 160 Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Thr 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Asp Thr 180 185 190 Ile Ser Leu Glu Ile Leu Met Ile Ser Asn Asn Gly Leu Val Ser Trp 195 200 205 Leu Ile Phe Phe Phe Leu Leu Ile Ser Tyr Thr Val Ile Leu Met Met 210 215 220 Leu Arg Ser His Ala Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 225 230 235 240 Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Thr Asp Lys Ala Ile Ser 260 265 270 Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Lys Ser Ala Met Arg Arg Leu Lys Lys Arg 290 295 300 Leu Gly His Ser Glu Arg Ile 305 310

<210> 501 <211> 936 <212> DNA <213> Canis familiaris

Page 557

069269_0225_SL.TXT <400> 501 atggagttgg gaaatagcac aaggataaaa gaatttatat ttctggggct tactcagtcc 60 catgacctga gcttgatctt atttctttct ttgtgtttgg tgtacgtgat aactcttctg 120 ggaaacctcc tcatcatggt cactgtgacc tgtgagtccc gccttcacac ccccatgtac 180 ttcctgctcc gcaacctagc cgtccttgac atctgcttct cctccatcac tgctcccaag 240 gttctcatag accttctgtc aaagataaag accatctcct atacaagctg catgacacag 300 atgttcttct tccaccttct cggtggggca gacatttttt ctctctctgt gatggccttt 360 gaccgctaca tggccatctc caagcccttg cactatgtga ccatcatgag tagagggcga 420 tgcactgccc tcattgtggc ctcctgggtg gggggctttg tccactccat tgtgcagatt 480 tccctgttgc tgcccctccc cttctgtggc cccaatgttc ttgacacttt ctactgcgat 540 gtcccccagg tcctcaaact tgcctgcact gacacctttg cacttgagct cctgatgatt 600 tccaacaatg gcttagtcac tactttgtgg tttattttcc tcctggtgtc ctacacagtc 660 atcttgacaa tcctgaggtc tcaggcaggg gagggcagga ggaaagccat ctccacctgc 720 acctcccaca tcactgtggt gaccctgcat tttgtgccct gtatctatgt ctatgcccgg 780 cccttcactg ccctccccac agataaagcc atctctgtca ccttcacagt catctcccca 840 ctgctgaacc ccatgatcta caccctgagg aaccaggaga tgaaatcagc catgaggaga 900 ttaagcagaa gactcacacc ctttgtgatg gaatag 936 <210> 502 <211> 311 <212> PRT <213> Canis familiaris <400> 502

Met 1 Glu Leu Gly Asn Ser Thr Arg Ile Lys Glu Phe Ile Phe Leu Gly 5 10 15 Leu Thr Gln Ser His Asp Leu Ser Leu Ile Leu Phe Leu Ser Leu Cys 20 25 30 Leu Val Tyr Val Ile Thr Leu Leu Gly Asn Leu Leu Ile Met Val Thr 35 40 45

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Val Thr 50 Cys Glu Ser Arg Leu 55 069269_0225_SL.TXT His Thr Pro Met Tyr Phe 60 Leu Leu Arg Asn Leu Ala Val Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Val Leu Ile Asp Leu Leu Ser Lys Ile Lys Thr Ile Ser Tyr Thr Ser 85 90 95 Cys Met Thr Gln Met Phe Phe Phe His Leu Leu Gly Gly Ala Asp Ile 100 105 110 Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Met Ala Ile Ser Lys 115 120 125 Pro Leu His Tyr Val Thr Ile Met Ser Arg Gly Arg Cys Thr Ala Leu 130 135 140 Ile Val Ala Ser Trp Val Gly Gly Phe Val His Ser Ile Val Gln Ile 145 150 155 160 Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Thr 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Ala Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Val Thr Thr 195 200 205 Leu Trp Phe Ile Phe Leu Leu Val Ser Tyr Thr Val Ile Leu Thr Ile 210 215 220 Leu Arg Ser Gln Ala Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 225 230 235 240 Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255

Page 559

Val Tyr Ala Arg 260 Pro Phe Thr 069269_0225_SL.TXT Ala Leu Pro Thr Asp Lys 265 Ala 270 Ile Ser Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Lys Ser Ala Met Arg Arg Leu Ser Arg Arg 290 295 300 Leu Thr Pro Phe Val Met Glu

305 310 <210> 503 <211> 936 <212> DNA <213> Canis familiaris <400> 503

atggagctga aaaattgcac cagggtgaaa gaatttgctt tccttggcct aacccagaat 60 caaggactga gcttggtctt atttcttttc ctgcttctgg tatatgtgac aactctgctg 120 ggaaacctcc tcatcatggt cactgtcacc tgtgagtccc gtcttcacac ccccatgtac 180 ttcctgctcc gtaatttatc tgttgccgac atctgctttt cctccatcac agctcccaag 240 gttctgatgg accttctgtc acaaagaaag acaatctcct ttaatgggtg cttcacccag 300 atgttttttt tccaccttgt tggaggggtg gatgtatttt ctttgtcagt gatggcattg 360 gatcgatatg tggccatctc caagcccctg cactatgtga ccattatgag tagaggccgt 420 tgcattggat taatagtggc ctcctgggtg ggaggcttta cccactccat tgtacagatt 480 tccctgttgc ttccgctccc cttctgtggg cccaatgttc ttgacacttt ctactgcgat 540 gttccacagg tcctcaagct cgcctgtaca gacattttta tgcttgagtt gctgatgatt 600 tccaataatg gactgctcac cacactgtgg tttttcttcc tcctggtatc atatatggtc 660 atattagtag tagtaaagtc tcaggcaggg gagggcagga ggaaagccat ctccacctgc 720 acttcccaca tcactgtagt gacgctgcac tttgtgccct gcatctatgt ctatgcccgg 780 cccttcactg ctctccccac agataaagcc atctctgtca ccttcacagt catctctcct 840 ctgctgaacc ccttgatcta tactctgagg aaccaggaga tgaagtcagc catgaggaga 900

Page 560

936

069269_0225_SL.TXT ttgaagagaa gactcatgcc ttctgacagg gaatag <210> 504 <211> 311 <212> PRT <213> Canis familiaris <400> 504

Met 1 Glu Leu Lys Asn 5 Cys Thr Arg Val Lys Glu Phe Ala Phe Leu Gly 10 15 Leu Thr Gln Asn Gln Gly Leu Ser Leu Val Leu Phe Leu Phe Leu Leu 20 25 30 Leu Val Tyr Val Thr Thr Leu Leu Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Thr Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ser Val Ala Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Val Leu Met Asp Leu Leu Ser Gln Arg Lys Thr Ile Ser Phe Asn Gly 85 90 95 Cys Phe Thr Gln Met Phe Phe Phe His Leu Val Gly Gly Val Asp Val 100 105 110 Phe Ser Leu Ser Val Met Ala Leu Asp Arg Tyr Val Ala Ile Ser Lys 115 120 125 Pro Leu His Tyr Val Thr Ile Met Ser Arg Gly Arg Cys Ile Gly Leu 130 135 140 Ile Val Ala Ser Trp Val Gly Gly Phe Thr His Ser Ile Val Gln Ile 145 150 155 160 Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Thr 165 170 175

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Phe Tyr Cys Asp 180 Val Pro Phe Met Leu 195 Glu Leu Leu Leu Trp 210 Phe Phe Phe Leu Val 225 Lys Ser Gln Ala Gly 230 Thr Ser His Ile Thr 245 Val Val Tyr Ala Arg 260 Pro Phe Val Thr Phe 275 Thr Val Ile Leu Arg 290 Asn Gln Glu Met Leu 305 Met Pro Ser Asp Arg 310

Glu

Gln Val Leu 185 Lys Leu Met Ile 200 Ser Asn Asn Leu 215 Val Ser Tyr Met Glu Gly Arg Arg Lys 235 Val Thr Leu His 250 Phe Thr Ala Leu 265 Pro Thr Ser Pro 280 Leu Leu Asn Lys 295 Ser Ala Met Arg

Ala Cys Thr 190 Asp Ile Gly Leu 205 Leu Thr Thr Val 220 Ile Leu Val Val Ala Ile Ser Thr Cys 240 Val Pro Cys Ile 255 Tyr Asp Lys Ala 270 Ile Ser Pro Leu 285 Ile Tyr Thr Arg 300 Leu Lys Arg Arg

<210> 505 <211> 930 <212> DNA <213> Canis familiaris <400> 505 atggaacaaa acaatggcac cacaagtctt ggcatatcct gggaatattg ggatgatcct tttttcctac aacacctggc atgctgcaaa accttgtaga taaagtaact gaattcatcc cttcatagtg tttctagtga actcatcaag attgattctc atttgtggat ctctgctaca aacagagcaa tccatctcat Page 562 tcctgggatt tgctggtcaa tctatgtggc caccctaatg gccttcacac cccaatgtac cctctgctat cactcccaag tcataggatg tatggtgcaa

120

180

240

300

069269_0225_SL.TXT

ttactagtct atggagcttt tgcaacaacc gactgctaca tcctggctgc aatggcagtg 360 gacaggtatg tggccatctg caacccactc cgctatccga cagtcatgtc ccaggcagtc 420 tgcattcaac tcctgattgg ctcatacttc gtaggcttct tgaatgcctc tgtaaacaca 480 agttttgctt tttcattgaa cttttgcaaa tccaataaaa ttaaccactt tttctgtgat 540 gaacccccac tccttgccct ctcgtgctcc aacattgact tcaacatcat gctactaact 600 gtctttgtgg ggtttaactt gatgttcact gtgctggttg tcatcttttc ctacatatat 660 attctggctg ccatcctgaa gatatcttct gctgcaggga ggaagaaagc cttctccaca 720 tgcgcctccc acttgacagc agtcataatt ttctatggga ctctctctta catgtacctg 780 catcatggga ccaaggagtc tcaagagcaa gaaaaaatgg cttctgtgtt ttatggcatt 840 atgatcccca tgttaaaccc cctcatctac agcctgagaa accaagatgt gaaggaagcc 900 ctaaaaggga ttccaaagaa ggccttctag 930 <210> 506 <211> 309 <212> PRT <213> Canis familiaris <400> 506 Met Glu Gln Asn Asn Gly Thr Lys Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Ala Gly Gln His Lys Ser Trp His Ile Leu Phe Ile Val Phe Leu 20 25 30 Val Ile Tyr Val Ala Thr Leu Met Gly Asn Ile Gly Met Ile Leu Leu 35 40 45 Ile Lys Ile Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gln 50 55 60 His Leu Ala Phe Val Asp Leu Cys Tyr Thr Ser Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Gln Asn Leu Val Glu Thr Glu Gln Ser Ile Ser Phe Ile Gly

85 90 95

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Cys Met Val Gln 100 Leu Leu Val Tyr Gly Ala Phe Ala Thr Thr Asp Cys 105 110 Tyr Ile Leu Ala Ala Met Ala Val Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Thr Val Met Ser Gln Ala Val Cys Ile Gln Leu 130 135 140 Leu Ile Gly Ser Tyr Phe Val Gly Phe Leu Asn Ala Ser Val Asn Thr 145 150 155 160 Ser Phe Ala Phe Ser Leu Asn Phe Cys Lys Ser Asn Lys Ile Asn His 165 170 175 Phe Phe Cys Asp Glu Pro Pro Leu Leu Ala Leu Ser Cys Ser Asn Ile 180 185 190 Asp Phe Asn Ile Met Leu Leu Thr Val Phe Val Gly Phe Asn Leu Met 195 200 205 Phe Thr Val Leu Val Val Ile Phe Ser Tyr Ile Tyr Ile Leu Ala Ala 210 215 220 Ile Leu Lys Ile Ser Ser Ala Ala Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Val Ile Ile Phe Tyr Gly Thr Leu Ser 245 250 255 Tyr Met Tyr Leu His His Gly Thr Lys Glu Ser Gln Glu Gln Glu Lys 260 265 270 Met Ala Ser Val Phe Tyr Gly Ile Met Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Asp Val Lys Glu Ala Leu Lys Gly Ile 290 295 300

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Pro Lys Lys Ala Phe 305 <210> 507 <211> 939 <212> DNA <213> Canis familiaris <400> 507

atggaagtag gaaaccgtac cattctgact gaattcatct tggtgggctt ctcagcagac 60 ccacggtggc agctgattct atttggaata tttctgatgc tctatttgat gactttgtca 120 gggaacatga ccctggttat cctaatccga attgattccc gcctgcacac ccctatgtac 180 ttcttcattg gcaatttgtc ctttttggat ttttggtaca cttctgtgta tactcccaaa 240 atcttggcta attgtgtctc agaagataaa cgtatttcct tggctggatg tggagcccag 300 ttgttctttt cctgtgttgt agcctacaca gaatgctatc tcctagccgc catggcatat 360 gaccggtatg cagcaatctg taacccattg ctttattcaa gtatgatgtc caattctctc 420 tgtactgggc ttgttgctgg ctcctactta ggaggacttt tgaatgccat agcccatact 480 gctaacactt tccgcttgag tttctgtggt aaaaatatca ttgaccactt cttctgtgat 540 gcaccaccat tggtaaaaat gtcttgtaca gatacccatg tctatgaaaa agtcctcctg 600 ggtgtggtgg gcttcacagt cctctccagc attcttgcca tcctggtttc ctattgcaac 660 atccttctgg ctatcctgag gatccgctcg gcttcaggaa ggcgcaaagc cttctccacc 720 tgtgcttcac acctcatttc ggtcatgctc ttctatggat ccttgctctt catgtattca 780 aggccaagtt ccacctactc cctggagaga gacaaagtgg ctgctctgtt ctacactgtg 840 gtcaacccat tgctcaaccc tctcatctat agcctgagaa acaaagacgt caaagaggcc 900 ttctggaaag caacacaaac cataaggctg cagagatga 939

<210> 508 <211> 312 <212> PRT <213> Canis familiaris <400> 508

Met Glu Val Gly Asn Arg Thr Ile Leu Thr Glu Phe Ile Leu Val Gly Page 565

0 6926 9_02 25_S L.TX T 1 5 10 15 Phe Ser Ala Asp Pro Arg Trp Gln Leu Ile Leu Phe Gly Ile Phe Leu 20 25 30 Met Leu Tyr Leu Met Thr Leu Ser Gly Asn Met Thr Leu Val Ile Leu 35 40 45 Ile Arg Ile Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Ile Gly 50 55 60 Asn Leu Ser Phe Leu Asp Phe Trp Tyr Thr Ser Val Tyr Thr Pro Lys 65 70 75 80 Ile Leu Ala Asn Cys Val Ser Glu Asp Lys Arg Ile Ser Leu Ala Gly 85 90 95 Cys Gly Ala Gln Leu Phe Phe Ser Cys Val Val Ala Tyr Thr Glu Cys 100 105 110 Tyr Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ser Ser Met Met Ser Asn Ser Leu Cys Thr Gly Leu 130 135 140 Val Ala Gly Ser Tyr Leu Gly Gly Leu Leu Asn Ala Ile Ala His Thr 145 150 155 160 Ala Asn Thr Phe Arg Leu Ser Phe Cys Gly Lys Asn Ile Ile Asp His 165 170 175 Phe Phe Cys Asp Ala Pro Pro Leu Val Lys Met Ser Cys Thr Asp Thr 180 185 190 His Val Tyr Glu Lys Val Leu Leu Gly Val Val Gly Phe Thr Val Leu 195 200 205 Ser Ser Ile Leu Ala Ile Leu Val Ser Tyr Cys Asn Ile Leu Leu Ala

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210 215 Gly Arg 220 Arg Lys Ala Phe Ser Thr Ile 225 Leu Arg Ile Arg Ser 230 Ala Ser 235 240 Cys Ala Ser His Leu Ile Ser Val Met Leu Phe Tyr Gly Ser Leu Leu 245 250 255 Phe Met Tyr Ser Arg Pro Ser Ser Thr Tyr Ser Leu Glu Arg Asp Lys 260 265 270 Val Ala Ala Leu Phe Tyr Thr Val Val Asn Pro Leu Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Phe Trp Lys Ala 290 295 300 Thr Gln Thr Ile Arg Leu Gln Arg 305 310

<210> 509 <211> 930 <212> DNA <213> Canis familiaris <400> 509

atggaaaatc agaacaatgt cacagaattt gttttcatgg ggctatgggg aaataagcaa 60 ctagaactac tgttcttttt cttgttcctg ctctgctacc tggctgtctt aatgggaaac 120 ttcattatct tactcacgat cacctgcagc catctaattg aacatccgat gtactatttt 180 ctctgtcacc tttccctcat ggacctctgc tacacctcca ctgtggtccc caggctaatc 240 agggacttag gtgcagcaag aaaaaacatt tcctataaca actgtatgac ccagctcttc 300 actgcccact tgctggcagg ggtggagata ttcatcttgg tgtccatggc tttagaccgc 360 tatgttgcca ttgtcaagcc cctgcattac atggtcatca tgaaccgacg gaggtgtaac 420 ctgttgattt ttatggcctg gggtgtgggg ttttggcact ctgttgctct attgctcatg 480 gtactcaatt tacctttctg tggtcctaat cagatagatc attacatatg tgatgtgaag 540 cctcttttga aactggtgtg cagagatatt cgtgttgtta gtatcttagt gattgcaaac 600

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tcaggaatgg tggtggttgt catttttctt gtcctggtgg cttcttacat tctcatatta 660 tataatctta ggacccactc ctctgtaggg agactcaaag ctctctccac ctgcagctct 720 catgtaatgg tggtcatttt attctttgtg ccttgtatct atacttatgt tctacctgca 780 gggagtgaga acaaggataa ggaaatctct gtgttttaca ctgtaattgc tcccatgctg 840 aatcctctca tctatacctt aagaaacatg gagatgaaaa tcgccatgcg gaaggtgtgg 900 tctaaagtgg cacattcaga attcaaataa 930

<210> 510 <211> 309 <212> PRT <213> Canis familiaris <400> 510

Met Glu Asn Gln Asn Asn Val Thr Glu Phe Val Phe Met Gly Leu Trp 1 5 10 15 Gly Asn Lys Gln Leu Glu Leu Leu Phe Phe Phe Leu Phe Leu Leu Cys 20 25 30 Tyr Leu Ala Val Leu Met Gly Asn Phe Ile Ile Leu Leu Thr Ile Thr 35 40 45 Cys Ser His Leu Ile Glu His Pro Met Tyr Tyr Phe Leu Cys His Leu 50 55 60 Ser Leu Met Asp Leu Cys Tyr Thr Ser Thr Val Val Pro Arg Leu Ile 65 70 75 80 Arg Asp Leu Gly Ala Ala Arg Lys Asn Ile Ser Tyr Asn Asn Cys Met 85 90 95 Thr Gln Leu Phe Thr Ala His Leu Leu Ala Gly Val Glu Ile Phe Ile 100 105 110 Leu Val Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Val Lys Pro Leu 115 120 125

Page 568

His Tyr 130 Met Val Ile Met Asn 135 069269_0225_SL.TXT Arg Arg Arg Cys Asn Leu 140 Leu Ile Phe Met Ala Trp Gly Val Gly Phe Trp His Ser Val Ala Leu Leu Leu Met 145 150 155 160 Val Leu Asn Leu Pro Phe Cys Gly Pro Asn Gln Ile Asp His Tyr Ile 165 170 175 Cys Asp Val Lys Pro Leu Leu Lys Leu Val Cys Arg Asp Ile Arg Val 180 185 190 Val Ser Ile Leu Val Ile Ala Asn Ser Gly Met Val Val Val Val Ile 195 200 205 Phe Leu Val Leu Val Ala Ser Tyr Ile Leu Ile Leu Tyr Asn Leu Arg 210 215 220 Thr His Ser Ser Val Gly Arg Leu Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Val Met Val Val Ile Leu Phe Phe Val Pro Cys Ile Tyr Thr Tyr 245 250 255 Val Leu Pro Ala Gly Ser Glu Asn Lys Asp Lys Glu Ile Ser Val Phe 260 265 270 Tyr Thr Val Ile Ala Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Met Glu Met Lys Ile Ala Met Arg Lys Val Trp Ser Lys Val Ala 290 295 300 His Ser Glu Phe Lys

<210> 511 <211> 930 <212> DNA <213> Canis familiaris

305

Page 569

069269_0225_SL.TXT <400> 511 atggagaata gaaacaatgt gacagagttt gttctactgg ggctcacaga gaatccaaag 60 atgcagaaaa tcgtttttgt tgtgtttttg atcatctaca tcgtctctgt ggtaggaaat 120 gtgctcactg tggcagctat caccgccagc ccattattgg ggtcccccat gtactttttc 180 ctggcctatc tttccttcat tgatgcctgc tattcttctg tcaataaccc taaactgatt 240 gtagattcac tccgtgaaaa gaagaccacc acattcaatg catgtataac ccaaatcttt 300 ggggaacatt tttttggagg tgctgatgtc atcttgctta ctgtgatggc ctatgaccgc 360 tatgtggcca tctgcaagcc actgcactac atgatcatca tgaatcggca ggtgtgtggc 420 ttgctcatgg cagtggtgtg ggtgggaggc tttcttcatg cagccataca gatcctcttt 480 atcatccctc tacctttctg tggccctaat gtcatagatc actttatgtg tgatctgaat 540 cctttgctca atcttgcctg cactgatacc cacactcttg ggttctttgt tgctgccaac 600 agtggtttca tctgtgcctt aaacttcctc ctcctcatgg tctcctatgt ggtcattctg 660 cactccctaa ggaaccacag cttggaggcg agactcaaag ccctctccac ctgtgtctcc 720 cacatcacag tggtcgtctt attctttgtg ccctgtatat ttgtgtacat gagacctgca 780 gctactttac ctattgataa agcagttgca gttttctaca ctatgataac acccatgtta 840 aatcccttaa tatatgcctt gagaaatgat cagatgaaaa atgccattag gaaattgtgc 900 agtagaaaag ttatttcaga tgcgaaataa 930 <210> 512 <211> 309 <212> PRT <213> Canis familiaris <400> 512

Met 1 Glu Asn Arg Asn Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr 5 10 15 Glu Asn Pro Lys Met Gln Lys Ile Val Phe Val Val Phe Leu Ile Ile 20 25 30 Tyr Ile Val Ser Val Val Gly Asn Val Leu Thr Val Ala Ala Ile Thr 35 40 45

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Ala Ser 50 Pro Leu Leu Gly Ser Pro 55 Met Tyr Phe Phe Leu Ala Tyr 60 Leu Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Asn Asn Pro Lys Leu Ile 65 70 75 80 Val Asp Ser Leu Arg Glu Lys Lys Thr Thr Thr Phe Asn Ala Cys Ile 85 90 95 Thr Gln Ile Phe Gly Glu His Phe Phe Gly Gly Ala Asp Val Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Ile Ile Met Asn Arg Gln Val Cys Gly Leu Leu Met Ala 130 135 140 Val Val Trp Val Gly Gly Phe Leu His Ala Ala Ile Gln Ile Leu Phe 145 150 155 160 Ile Ile Pro Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met 165 170 175 Cys Asp Leu Asn Pro Leu Leu Asn Leu Ala Cys Thr Asp Thr His Thr 180 185 190 Leu Gly Phe Phe Val Ala Ala Asn Ser Gly Phe Ile Cys Ala Leu Asn 195 200 205 Phe Leu Leu Leu Met Val Ser Tyr Val Val Ile Leu His Ser Leu Arg 210 215 220 Asn His Ser Leu Glu Ala Arg Leu Lys Ala Leu Ser Thr Cys Val Ser 225 230 235 240 His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Val Tyr 245 250 255

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Met Arg Pro Ala 260 Ala Thr Leu Pro Ile Asp Lys Ala Val Ala Val Phe 265 270 Tyr Thr Met Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Ala Leu Arg 275 280 285 Asn Asp Gln Met Lys Asn Ala Ile Arg Lys Leu Cys Ser Arg Lys Val 290 295 300

Ile Ser Asp Ala Lys 305 <210> 513 <211> 930 <212> DNA <213> Canis familiaris <400> 513

atgacaagcc agagaaacat ctccgaattc atacttctag gactttcata tgaccagagc 60 atacagatat tttgttttgt cattttctta ctctgttatg ttgctctgtt ggcaggaaat 120 cttctgatcc ttatctccat tcgatgcagc cctctttttc accaaccaat gtactacttc 180 cttatacact tatccttaat agacatctgc tacacctcta cagttacacc caagttaatt 240 ggtgacttgc tagtggaaag gaaaaccatc tcctatgaca attgcatgtt acaggtcttt 300 acaatgcact tctttggagg catcgagatc ttcattctca ccgccatggc ctttgatcgc 360 tatgctgcca tctgcaaacc tctccactat gtgattatca tgaacaggac aagatgcaat 420 ctcctagtct tagctgcttg ggctggtggg gccattcatg cctttccttt attttctact 480 gcaattggtt tgcccttctg tggtcctaat gaaattgatc actatttttg tgatattttt 540 cctttgctta aagtggcctg tactgatact tacatcactg gtgtccttgt gattgccttt 600 tcgggtatgg tcgcattagt tacctttatt gtcttatctg tttcttatgg cattatactg 660 ttcactttaa gaaatctctc agctgaagga agacgcaaag ccctctctac ctgttggtct 720 catatcactg tggtcatctt attttttggg cctgtaatct ttatctacct taggccacct 780 actacttttc ctgaggacaa aatatttgct ctgttttaca ccatcattgc tcctatgttc 840 aatcccttaa tctatactct gagaaattca gagatgaaaa aagccatgag gaaagtttgg 900

Page 572

069269_0225_SL.TXT tgtccatcag tattttcaaa ggaagcatga

930 <210> 514 <211> 309 <212> PRT <213> Canis familiaris <400> 514

Met 1 Thr Ser Gln Arg 5 Asn Ile Ser Glu Phe Ile Leu Leu Gly Leu Ser 10 15 Tyr Asp Gln Ser Ile Gln Ile Phe Cys Phe Val Ile Phe Leu Leu Cys 20 25 30 Tyr Val Ala Leu Leu Ala Gly Asn Leu Leu Ile Leu Ile Ser Ile Arg 35 40 45 Cys Ser Pro Leu Phe His Gln Pro Met Tyr Tyr Phe Leu Ile His Leu 50 55 60 Ser Leu Ile Asp Ile Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Ile 65 70 75 80 Gly Asp Leu Leu Val Glu Arg Lys Thr Ile Ser Tyr Asp Asn Cys Met 85 90 95 Leu Gln Val Phe Thr Met His Phe Phe Gly Gly Ile Glu Ile Phe Ile 100 105 110 Leu Thr Ala Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Val Ile Ile Met Asn Arg Thr Arg Cys Asn Leu Leu Val Leu 130 135 140 Ala Ala Trp Ala Gly Gly Ala Ile His Ala Phe Pro Leu Phe Ser Thr 145 150 155 160 Ala Ile Gly Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175

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Cys Asp Ile Phe Pro Leu Leu Lys Val Ala Cys Thr Asp Thr Tyr Ile 180 185 190 Thr Gly Val Leu Val Ile Ala Phe Ser Gly Met Val Ala Leu Val Thr 195 200 205 Phe Ile Val Leu Ser Val Ser Tyr Gly Ile Ile Leu Phe Thr Leu Arg 210 215 220 Asn Leu Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Trp Ser 225 230 235 240 His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Val Ile Phe Ile Tyr 245 250 255 Leu Arg Pro Pro Thr Thr Phe Pro Glu Asp Lys Ile Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Met Lys Lys Ala Met Arg Lys Val Trp Cys Pro Ser Val 290 295 300 Phe Ser Lys Glu Ala

305 <210> 515 <211> 213 <212> DNA <213> Canis familiaris <400> 515 ggtagggtgg tggcagcctt ttttgttgtc ttggtggctt cttacatatt catatcacat aatcttagga cccactcctc cgccgggtaa tgcaaagctc tctccacgtg cagctctcat gtaatggtgg tagttttatt cttcatgccc tgtatctgta cttaggttct acctgcaggc agtgaggaca gagatgagga actctccgta ttt

120

180

213

Page 574

069269_0225_SL.TXT <210> 516 <211> 40 <212> PRT <213> Canis familiaris <400> 516

Val Gly Trp Trp Gln Pro Phe Leu Leu Ser Trp Trp Leu Leu Thr Tyr 1 5 10 15 Ser Tyr His Ile Ile Leu Gly Pro Thr Pro Pro Pro Gly Asn Ala Lys 20 25 30 Leu Ser Pro Arg Ala Ala Leu Met 35 40

<210> 517 <211> 912 <212> DNA <213> Canis familiaris <400> 517

atggagagcc agaggaatgt ctcagaattc attcttttgg gactttcgca tgaccagaac 60 atgcaaatat tttgctttgt gctcttctta ttctgttatg ctgctctctt ggtaggaaac 120 cttctgatcc ttgtctctat tcgatgcagc cctctttttc accaaccgat gtactacttc 180 ctcagccact tatccacttt ggacatctgc tatacctcta gcgttacacc caaattaatt 240 gctgacctgc tagtggaaag aaaagccatc tcctatggta attgtatgtt acaggtcttt 300 gccatgcact tctttggaac gattgaggtt ttaatcctta cagtcatggc ctttgatcgc 360 tatgctgcca tctgcaaacc tctccactac ctgcttatca tgaacaggac aaggtgtaat 420 ctcctagtct tagctgcttg ggctggtggg gctgtccact cctttcctca attttgtatg 480 gtaatcaggt tgcccttctg tgggcctaat gagattgatc actatttctg tgatatattt 540 cctttgctaa aggttgcctg cactgatacc tacatcactg gtgtccttat ggttgtcaat 600 tcgggaatgg ttaccttagt gacatttgtg gttttatttt tttcttatgt cattatatta 660 ttcactttaa gaaatcactc agcagaagga agacgcaaag ccctctctac ttgtggatct 720 catatcacgg ttatagtttt attttttggg ccttccatct ttgcctacct tagacctcca 780 actaatttcc ctgaggataa agtatttgct ctgttttaca ccatcattgc tcctatgttc 840

Page 575

069269_0225_SL.TXT aatcccttaa tctatactct gagaaattca gagatgaaaa atgccatgag aaaattttgg tgtcaaacat ga

900

912 <210> 518 <211> 303 <212> PRT <213> Canis familiaris <400> 518

Met Glu 1 Ser Gln Arg Asn Val Ser Glu Phe Ile Leu Leu Gly Leu Ser 5 10 15 His Asp Gln Asn Met Gln Ile Phe Cys Phe Val Leu Phe Leu Phe Cys 20 25 30 Tyr Ala Ala Leu Leu Val Gly Asn Leu Leu Ile Leu Val Ser Ile Arg 35 40 45 Cys Ser Pro Leu Phe His Gln Pro Met Tyr Tyr Phe Leu Ser His Leu 50 55 60 Ser Thr Leu Asp Ile Cys Tyr Thr Ser Ser Val Thr Pro Lys Leu Ile 65 70 75 80 Ala Asp Leu Leu Val Glu Arg Lys Ala Ile Ser Tyr Gly Asn Cys Met 85 90 95 Leu Gln Val Phe Ala Met His Phe Phe Gly Thr Ile Glu Val Leu Ile 100 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Leu Ile Met Asn Arg Thr Arg Cys Asn Leu Leu Val Leu 130 135 140 Ala Ala Trp Ala Gly Gly Ala Val His Ser Phe Pro Gln Phe Cys Met 145 150 155 160

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Val Ile Arg Leu Pro Phe Cys Gly Pro Asn 170 Glu Ile Asp His Tyr Phe 175 165 Cys Asp Ile Phe Pro Leu Leu Lys Val Ala Cys Thr Asp Thr Tyr Ile 180 185 190 Thr Gly Val Leu Met Val Val Asn Ser Gly Met Val Thr Leu Val Thr 195 200 205 Phe Val Val Leu Phe Phe Ser Tyr Val Ile Ile Leu Phe Thr Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Ile Thr Val Ile Val Leu Phe Phe Gly Pro Ser Ile Phe Ala Tyr 245 250 255 Leu Arg Pro Pro Thr Asn Phe Pro Glu Asp Lys Val Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Met Lys Asn Ala Met Arg Lys Phe Trp Cys Gln Thr 290 295 300 <210> 519 <211> 930 <212> DNA <213> Canis familiaris <400> 519 atggaaaatc agaacaatgt cacagaattt gttttcatgg gtctgtgggg aaataaacaa atggagctac tgttcttttt cctgttcctg ctctgctttt tggccatctt aatgggaaac ttcatcatct tactcacgat catctgcagc catctaattg aacaaccaat gtactacttt ctctgccacc tttctctcat ggacctctgc tacacttcca ctgtagtccc cagactaatc agggacttag gtgcagcaag aaaaaacatt tcctataaca actgtatgac ccagctcttc

120

180

240

300

Page 577

069269_0225_SL.TXT

actgcccact tgctggcagg ggtggagata ttcatcttgg tgtccatggc tttagaccgt 360 tatgtggcca ttgtcaagcc cctgcattac atggtcatca tgagccggcg gaggtgtaac 420 ctgttgattt tcatggcctg gagtgtgggg ttttggcact ctgttgctct attgctcttg 480 gtactcaatt tacctttctg tggtcctaat cagataaatc attacatatg tgatgtgaag 540 cctcttttga aactggtgtg cagagatatt cgtgttgtta atatcttagt gatttcaaac 600 tcaggaatgg tggcagttgt tgtgtttctt gtcctggtgg cttcttacat tctcatatta 660 tacaatctga ggacccactc ctctgtaggg agacgcaaag ctctctccac gtgcagctct 720 catgtaatgg tggtcatttt attctttgtg ccttgtatct atatttatgt tctacctgca 780 gggagtgaaa acaaggataa ggagatctct gtgttttaca ctgtgattgc tcccttgttg 840 aatcctctca tctataccct gagaaacatg gagatgagaa atgccatgtg gaaggtgtgg 900 tctaaaatgg cacatacgaa attcaggtaa 930 <210> 520 <211> 309 <212> PRT <213> Canis familiaris <400> 520 Met Glu Asn Gln Asn Asn Val Thr Glu Phe Val Phe Met Gly Leu Trp 1 5 10 15 Gly Asn Lys Gln Met Glu Leu Leu Phe Phe Phe Leu Phe Leu Leu Cys 20 25 30 Phe Leu Ala Ile Leu Met Gly Asn Phe Ile Ile Leu Leu Thr Ile Ile 35 40 45 Cys Ser His Leu Ile Glu Gln Pro Met Tyr Tyr Phe Leu Cys His Leu 50 55 60 Ser Leu Met Asp Leu Cys Tyr Thr Ser Thr Val Val Pro Arg Leu Ile 65 70 75 80 Arg Asp Leu Gly Ala Ala Arg Lys Asn Ile Ser Tyr Asn Asn Cys Met

85 90 95

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Thr Gln Leu Phe 100 Thr Ala His Leu Leu Ala Gly Val Glu Ile Phe Ile 105 110 Leu Val Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Val Lys Pro Leu 115 120 125 His Tyr Met Val Ile Met Ser Arg Arg Arg Cys Asn Leu Leu Ile Phe 130 135 140 Met Ala Trp Ser Val Gly Phe Trp His Ser Val Ala Leu Leu Leu Leu 145 150 155 160 Val Leu Asn Leu Pro Phe Cys Gly Pro Asn Gln Ile Asn His Tyr Ile 165 170 175 Cys Asp Val Lys Pro Leu Leu Lys Leu Val Cys Arg Asp Ile Arg Val 180 185 190 Val Asn Ile Leu Val Ile Ser Asn Ser Gly Met Val Ala Val Val Val 195 200 205 Phe Leu Val Leu Val Ala Ser Tyr Ile Leu Ile Leu Tyr Asn Leu Arg 210 215 220 Thr His Ser Ser Val Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Val Met Val Val Ile Leu Phe Phe Val Pro Cys Ile Tyr Ile Tyr 245 250 255 Val Leu Pro Ala Gly Ser Glu Asn Lys Asp Lys Glu Ile Ser Val Phe 260 265 270 Tyr Thr Val Ile Ala Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Met Glu Met Arg Asn Ala Met Trp Lys Val Trp Ser Lys Met Ala 290 295 300

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His Thr Lys Phe Arg

305 <210> 521 <211> 933 <212> DNA <213> Canis familiaris <400> 521

atgcagcaaa ataacagcgt aacagagttc atactattag gactaaccca agaccctatc 60 agacagaaaa tgatatttgt aatcttctcc attttttatg tgggaactgt ggttgggaat 120 ttgcttatta ttgtgaccat caagtctagc cggacacttg ggagccccat gtactttttc 180 ctattttatt tgtcccttgc tgattcctgc ttttcaactt ccacagcccc cagactaatt 240 gtggattcac tctctgcaaa aaaaatcata acttacaatg agtgcatgac tcaagtcttt 300 gcactacatt tatttggctg catggagatc tttgtcctca tcctcatggc cgttgatcgc 360 tatgtggcca tctgtatgcc tttacgttac ccaaccatca tgagacggca ggtctgcacc 420 atcctaattg ttctggcatg gattggatct tttatccatt ctatagccca gattatcctg 480 gctttgagat tgcccttctg tggaccgaat ttgattgatc attactgctg tgatttgcag 540 cccttgctga aacttgcttg catggacact tataagatca acctattgtt ggtgtctaat 600 agtggggcca tttgctcaag cagttttgtg attctgatga tctcctatat tgtcatcttg 660 cattccctgc gaaaccacag tgcggaaggg aagaaaaaag ctctctctac ttgtacttct 720 cacatcattg tagtaatctt attctttggt ccatgtatat tcatttatac acgcccccca 780 actactttcc ccatggacaa gatggtggcc gtattttata ctattgggac accttttctc 840 aatccactta tctacacact gaggaatgca gaagtgaaaa atgccatgaa aaagctatgg 900 catatcaaaa ttacctcaga aagcaaaaaa tga 933

<210> 522 <211> 310 <212> PRT <213> Canis familiaris <400> 522

Met Gln Gln Asn Asn Ser Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15

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Gln Asp Pro Ile 20 Arg Gln Lys Met Ile Phe Val Ile Phe Ser Ile Phe 25 30 Tyr Val Gly Thr Val Val Gly Asn Leu Leu Ile Ile Val Thr Ile Lys 35 40 45 Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Leu Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ser Leu Ser Ala Lys Lys Ile Ile Thr Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Leu His Leu Phe Gly Cys Met Glu Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Val Asp Arg Tyr Val Ala Ile Cys Met Pro Leu 115 120 125 Arg Tyr Pro Thr Ile Met Arg Arg Gln Val Cys Thr Ile Leu Ile Val 130 135 140 Leu Ala Trp Ile Gly Ser Phe Ile His Ser Ile Ala Gln Ile Ile Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Leu Ile Asp His Tyr Cys 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Lys 180 185 190 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Ser Ser Ser 195 200 205 Phe Val Ile Leu Met Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220

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Asn His 225 Ser Ala Glu Gly 230 Lys Lys Lys Ala Leu 235 Ser Thr Cys Thr Ser 240 His Ile Ile Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Pro Thr Thr Phe Pro Met Asp Lys Met Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp His Ile Lys Ile 290 295 300 Thr Ser Glu Ser Lys Lys

305 310 <210> 523 <211> 933 <212> DNA <213> Canis familiaris <400> 523

atgcagcaaa ataacagcgt aacagagttc atactgttag gactaaccca agatcctatg 60 agacagaaaa tggtatttgt aatcttctcc attttatatg tgggaactgt ggttgggaat 120 ttgcttatta ttgtgaccat caagtctagc cggacacttg ggagccccat gtactttttc 180 ttattttatt tgtcccttgc tgattcctgc ttttcaactt ccacagcccc cagactaatt 240 gtggattcac tctctgcaaa aaaaatcata acttacaatg agtgcatgac tcaagtcttt 300 gcactacact tatttggctc catggagatc tttgtcctca tcctaatggc ctttgaccgg 360 tatgtggcca tctgtatgcc tttacgttac ccaaccatca tgagacggca ggtctgcacc 420 atcctaattg ttctggcatg gattggatct tttatccatt ctacagccca gattatcctg 480 gctttgagat tgcccttctg tggacccaat ttgattgatc attactgctg tgatttgcag 540 cccttgctga aacttgcctg catggacact tatgtgatca acctactgtt ggtgtctaat 600

Page 582

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agtggggcca tttgctcaag cagttttgtg attctgatga tctcctacat tgtcatcttg 660 cattccctgc gaaaccacag tgcagaaggg aagaaaaaag ctctctctac ttgcacttct 720 cacatcattg tagtaatctt attctttggt ccatgtatat tcatttatac acgcccgcca 780 actactttcc ccatggacaa gatggtaact gtattttata ctattgggac accttttctc 840 aatccactta tctacacact gaggaatgca gaagtgaaaa atgccatgaa aaatctatgg 900 catgtcaaaa ttacctcaga aagcaaaaga tga 933

<210> 524 <211> 310 <212> PRT <213> Canis familiaris <400> 524

Met 1 Gln Gln Asn Asn Ser Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 5 10 15 Gln Asp Pro Met Arg Gln Lys Met Val Phe Val Ile Phe Ser Ile Leu 20 25 30 Tyr Val Gly Thr Val Val Gly Asn Leu Leu Ile Ile Val Thr Ile Lys 35 40 45 Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Leu Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ser Leu Ser Ala Lys Lys Ile Ile Thr Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Leu His Leu Phe Gly Ser Met Glu Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Met Pro Leu 115 120 125 Arg Tyr Pro Thr Ile Met Arg Arg Gln Val Cys Thr Ile Leu Ile Val

Page 583

130 135 069269_0225_SL.TXT 140 Leu Ala Trp Ile Gly Ser Phe Ile His Ser Thr Ala Gln Ile Ile Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Leu Ile Asp His Tyr Cys 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Ser Ser Ser 195 200 205 Phe Val Ile Leu Met Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Lys Lys Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Ile Ile Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Pro Thr Thr Phe Pro Met Asp Lys Met Val Thr Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Asn Leu Trp His Val Lys Ile 290 295 300 Thr Ser Glu Ser Lys Arg 305 310

<210> 525 <211> 192 <212> DNA <213> Canis familiaris

Page 584

069269_0225_SL.TXT <400> 525 ttttcttggc catgtacttt catgtatatt tgctctgata ctaccttttc aggggataag 60 atgatggctg tattttacac cattatcacc ctcatgttaa atcctctgat ccacaccctg 120 agaaacacag aagtaaagaa tgcaatgaaa agactgtggg gcaggaagat tttgtcagag 180 gctaatggta aa 192 <210> 526 <211> 64 <212> PRT <213> Canis familiaris <400> 526

Phe Ser Trp Pro Cys Thr Phe Met Tyr Ile Cys Ser Asp Thr Thr Phe 1 5 10 15 Ser Gly Asp Lys Met Met Ala Val Phe Tyr Thr Ile Ile Thr Leu Met 20 25 30 Leu Asn Pro Leu Ile His Thr Leu Arg Asn Thr Glu Val Lys Asn Ala 35 40 45 Met Lys Arg Leu Trp Gly Arg Lys Ile Leu Ser Glu Ala Asn Gly Lys 50 55 60

<210> 527 <211> 804 <212> DNA <213> Canis familiaris <400> 527 gtggtcacta tcactgccag cccattatcg gggtccccca tgtacttttt tctggcctat 60 ctctccctca ttgatgcctg ctattctttt gtcaataccc ctacactcat catagagtca 120 ctccgtgaaa agaagaccat cccattcaat gcatgcataa tccaaatctt tggggaacat 180 tttttttttg gaggtgctga tgtcatcctg cttactgtga tggcctatga cagctatgta 240 gctatctgca agccactgca ctacatgacc atcatgaatt agcaggtatg tggcctgctc 300 atggcagtgg agtgggtggg aggctttcct catgcagcca tacagatctt ctttatcatc 360 ccactaccct tctgtggccc taatgtcata gatcacttta tatgtgatct gaatcctttg 420

Page 585

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ctcaatcttg cctgcactga tacccacact ctcagattct ttgttgctgc caacagtggt 480 ttcatctgtg tcttaaacct cctcctcctc ctcatggtct cctatgtggt cattctgcac 540 tccttaagga accacagctt tgaggcaagg tgcaaagccc tctccatctg tgtctcctac 600 atcacagtgg tcatcctata ctttgtgccc tgcatatttg tatacatgag acccgcagct 660 actttatcaa ttgataaagc tattacagtg ttctatacta caataactcc catgttaaat 720 cctttaatct ataccttgag aaatgaccag atgaaaaatg ccattaggaa actgtgtagt 780 aggaatgcta gtgtgggtga caaa 804

<210> 528 <211> 168 <212> PRT <213> Canis familiaris <400> 528

Met Ala Val Glu Trp Val Gly Gly Phe Pro His Ala Ala Ile Gln Ile 1 5 10 15 Phe Phe Ile Ile Pro Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His 20 25 30 Phe Ile Cys Asp Leu Asn Pro Leu Leu Asn Leu Ala Cys Thr Asp Thr 35 40 45 His Thr Leu Arg Phe Phe Val Ala Ala Asn Ser Gly Phe Ile Cys Val 50 55 60 Leu Asn Leu Leu Leu Leu Leu Met Val Ser Tyr Val Val Ile Leu His 65 70 75 80 Ser Leu Arg Asn His Ser Phe Glu Ala Arg Cys Lys Ala Leu Ser Ile 85 90 95 Cys Val Ser Tyr Ile Thr Val Val Ile Leu Tyr Phe Val Pro Cys Ile 100 105 110 Phe Val Tyr Met Arg Pro Ala Ala Thr Leu Ser Ile Asp Lys Ala Ile 115 120 125

Page 586

069269_0225_SL.TXT

Thr Val Phe Tyr Thr Thr Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr 130 135 140 Thr Leu Arg Asn Asp Gln Met Lys Asn Ala Ile Arg Lys Leu Cys Ser 145 150 155 160 Arg Asn Ala Ser Val Gly Asp Lys 165

<210> 529 <211> 936 <212> DNA <213> Canis familiaris <400> 529 atggagagag gcaatcatac agtgactgag ttcatcctgg tgggcttcac gacagaccca 60 gtgatgcagc tggtcctgtt tatggtattc cttggcgtgt actctctgac tgtggtagca 120 aacgccaccc tcatagtttt gatctgtaat gactcccggc tgcacacacc catgtatttt 180 ttcattggga atctatcttt tctggatgtc tggtattcct ctgtctacac accaaagatc 240 ctcatgacct gcatctctga agacaaaagc atctcctttg ctggctgtgt atgtcagttc 300 ttcttctctg ctgggttggc atatagtgag tgttacctgt tggccgccat ggcttacgac 360 cgctatgcag ccatttccaa ccccctgctg tatgctcaga caatgtcaag tagactgtgc 420 atctgtttgg ttgtatactc ttatactggt ggttttgtca atgcaataat acttaccagt 480 aacacattca cattggattt ttgtggtgac aatgtcatcg acgatttttt ctgtgatgtc 540 ccaccactgg tgaaattggc atgtgatgtg aaggagagct atcaggctgt gctgtacttc 600 cttctggcct ccaatgtcat cactcccacg gcgctcatcc ttgcttccta tgtgttcatc 660 attgctgcca tcttgaggat ccgctccacc cagggccgtc gcaaggcctt ctccacatgc 720 tcctcccacc tggtctcagt cactttgtac tatggctcca ttctctacat ctactctcgc 780 ccaagttcca gctattccct tgagagggac aaaatggtat caacatttta tactgtgcta 840 ttccccatgt tgaaccccat gatctatagt ctaaggaata aggatgtgaa agaagctctg 900 aaaaagctca tctggttaac acaatcagat gtctaa 936

Page 587

069269_0225_SL.TXT <210> 530 <211> 311 <212> PRT <213> Canis familiaris <400> 530

Met Glu Arg Gly Asn His Thr Val Thr Glu Phe Ile Leu Val Gly Phe 1 5 10 15 Thr Thr Asp Pro Val Met Gln Leu Val Leu Phe Met Val Phe Leu Gly 20 25 30 Val Tyr Ser Leu Thr Val Val Ala Asn Ala Thr Leu Ile Val Leu Ile 35 40 45 Cys Asn Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Ile Gly Asn 50 55 60 Leu Ser Phe Leu Asp Val Trp Tyr Ser Ser Val Tyr Thr Pro Lys Ile 65 70 75 80 Leu Met Thr Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys 85 90 95 Val Cys Gln Phe Phe Phe Ser Ala Gly Leu Ala Tyr Ser Glu Cys Tyr 100 105 110 Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Ser Asn Pro 115 120 125 Leu Leu Tyr Ala Gln Thr Met Ser Ser Arg Leu Cys Ile Cys Leu Val 130 135 140 Val Tyr Ser Tyr Thr Gly Gly Phe Val Asn Ala Ile Ile Leu Thr Ser 145 150 155 160 Asn Thr Phe Thr Leu Asp Phe Cys Gly Asp Asn Val Ile Asp Asp Phe 165 170 175 Phe Cys Asp Val Pro Pro Leu Val Lys Leu Ala Cys Asp Val Lys Glu 180 185 190

Page 588

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Ser Tyr Gln 195 Ala Val Leu Pro Thr 210 Ala Leu Ile Leu Leu 225 Arg Ile Arg Ser Thr 230 Ser Ser His Leu Val 245 Ser Ile Tyr Ser Arg 260 Pro Ser Val Ser Thr 275 Phe Tyr Thr Tyr Ser 290 Leu Arg Asn Lys Trp 305 Leu Thr Gln Ser Asp 310

Val

Tyr Phe 200 Leu Leu Ala Ala 215 Ser Tyr Val Phe Gln Gly Arg Arg Lys 235 Val Thr Leu Tyr 250 Tyr Ser Ser Tyr 265 Ser Leu Val Leu 280 Phe Pro Met Asp 295 Val Lys Glu Ala

Ser Asn 205 Val Ile Thr Ile 220 Ile Ala Ala Ile Ala Phe Ser Thr Cys 240 Gly Ser Ile Leu 255 Tyr Glu Arg Asp 270 Lys Met Leu Asn 285 Pro Met Ile Leu 300 Lys Lys Leu Ile

<210> 531 <211> 933 <212> DNA <213> Canis familiaris <400> 531 atgaagcaaa atatcagtat aaaaagaaag tggtatttgt ttgctaatta ttgtgaccat ttattttatt tgtcccttgc gtggattcac tctctacaaa gcactgcatt tctttggctg tactgagttc atactgttag aatcttcttc attttatatg caagtctagc cggacacttg tgattcctgc ttttcaactt aaatatcata acttacaatg catggagatc tttgtcgtca gattgaccca agatcctatg tgggaacgct ggcaggaaat ggagccccat gtactatttc ccacagcccc cagactaatt agtgcatgac tcaagtcttt tcttcatggc cgttgaccgc

120

180

240

300

360

Page 589

069269_0225_SL.TXT

tatgtggcaa tctgtaagcc cttacgttac ctaaacatca tgaactggca ggtctgcacc 420 atcctaattg ttctggcatg gattggatct tttatccatt ctatagccca gattatcctg 480 gctttgagat tgcccttctg tggacccaat ttgattgatc attactgctg tgatttgcag 540 cccttgctga aacttgcttg catggacact tatgtgatca acctactgtt ggtgtctaat 600 agcggggcca tttgctcaag cagttttgtg attctgatga tctcctacat tgtcatcttg 660 cattccctgc gaaaccacag tgcggaaggg aggaaaaaag ctctctctac ttgcacttct 720 cacatcatcg tagtagtctt atgctttggt ccatgcatat tcatatatac acggcctcca 780 accaccttct tcatggacaa gatggtaact gtattttata ctattgggac accttttctc 840 aacccactga tttatgcact aaggaatgca gaagtgaaaa atgccatgaa aaagctatgg 900 catatcaaaa ttacctcaga aagcagaaga tga 933

<210> 532 <211> 310 <212> PRT <213> Canis familiaris <400> 532

Met 1 Lys Gln Asn Ile Ser 5 Ile Thr Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Gln Asp Pro Met Lys Lys Lys Val Val Phe Val Ile Phe Phe Ile Leu 20 25 30 Tyr Val Gly Thr Leu Ala Gly Asn Leu Leu Ile Ile Val Thr Ile Lys 35 40 45 Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Tyr Phe Leu Phe Tyr Leu 50 55 60 Ser Leu Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ser Leu Ser Thr Lys Asn Ile Ile Thr Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Leu His Phe Phe Gly Cys Met Glu Ile Phe Val

Page 590

100

069269_0225_SL.TXT 105 110

Val Ile Phe 115 Met Ala Val Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 120 125 Arg Tyr Leu Asn Ile Met Asn Trp Gln Val Cys Thr Ile Leu Ile Val 130 135 140 Leu Ala Trp Ile Gly Ser Phe Ile His Ser Ile Ala Gln Ile Ile Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Leu Ile Asp His Tyr Cys 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Ser Ser Ser 195 200 205 Phe Val Ile Leu Met Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Lys Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Ile Ile Val Val Val Leu Cys Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Pro Thr Thr Phe Phe Met Asp Lys Met Val Thr Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Ala Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp His Ile Lys Ile 290 295 300 Thr Ser Glu Ser Arg Arg

Page 591

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305

310 <210> 533 <211> 933 <212> DNA <213> Canis familiaris <400> 533

atgcagcaaa ataacagtac tactgagttc atactgttag gattgaccca agatcctatg 60 aaaaagaaaa tggtatttgt aatatttttc attttttatt tgggaactgt ggttgggaat 120 ttgcttattg ttgtgaccat caagaccagc cggacacttg ggagccccat gtactatttc 180 ttattttatt tgtcccttgc tgattcctgc ttttcaactt ccacagcccc cagactaatt 240 gtggattcac tctctgcaaa aaatatcata acttacaatg aatgcatgac tcaagtcttt 300 gcactacatt tctttggttg catggaggtt ttagtcctta tccttatggc ctttgaccgg 360 tatgtggcca tctgtaagcc cttacattac ccaaccatca tgagccggcg ggtctgcacc 420 atcctaattg ttctggcatg gattggatct tttatccatt ctatagccca gattatcctg 480 gctttgaggt tgcccttctg tggaccgagt ttgattgatc attactgctg tgatttgcag 540 cccttgctga aacttgcttg catggacact tatgtgatca acctactgtt ggtgtctaat 600 agtggggcca tttgctcaag cagttttgtg attctgatga tctcctacat tgtcatcttg 660 cattccctgc gaaaccacag tgcggaaggg aggaaaaaag ctctctctac ttgtacttct 720 cacatcattg tagtaatcat attctttggt ccctgtatat tcatttatac acgtccccca 780 accactttcc ccatggacaa gatggtggcc gtattttata ctattgggac accttttctc 840 aacccactca tctacacatt gaggaatgca gaagtgaaaa atgccatgaa aaagctatgg 900 catatcaaga ttacctcaga aagcagaaga tga 933

<210> 534 <211> 310 <212> PRT <213> Canis familiaris <400> 534

Met Gln Gln Asn Asn Ser Thr Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15

Page 592

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Gln Asp Pro Met Lys Lys Lys Met Val Phe Val Ile Phe Phe Ile Phe 20 25 30 Tyr Leu Gly Thr Val Val Gly Asn Leu Leu Ile Val Val Thr Ile Lys 35 40 45 Thr Ser Arg Thr Leu Gly Ser Pro Met Tyr Tyr Phe Leu Phe Tyr Leu 50 55 60 Ser Leu Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ser Leu Ser Ala Lys Asn Ile Ile Thr Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Leu His Phe Phe Gly Cys Met Glu Val Leu Val 100 105 110 Leu Ile Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Pro Thr Ile Met Ser Arg Arg Val Cys Thr Ile Leu Ile Val 130 135 140 Leu Ala Trp Ile Gly Ser Phe Ile His Ser Ile Ala Gln Ile Ile Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Ser Leu Ile Asp His Tyr Cys 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Ser Ser Ser 195 200 205 Phe Val Ile Leu Met Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220

Page 593

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Asn His 225 Ser Ala Glu Gly Arg 230 Lys Lys Ala Leu Ser Thr 235 Cys Thr Ser 240 His Ile Ile Val Val Ile Ile Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Pro Thr Thr Phe Pro Met Asp Lys Met Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp His Ile Lys Ile 290 295 300 Thr Ser Glu Ser Arg Arg 305 310

<210> 535 <211> 930 <212> DNA <213> Canis familiaris <400> 535

atggggaata gaaacaatgt gacagagttt gttctactgg ggctcacaga gaatccaaag 60 atgcagaaaa tcgtttttgt tgtgtttttg atcatctaca tcatctctgt ggtaggaaat 120 gtgctcaccg tggcagctat caccaccagc ccattattgg ggtcccccat gtactttttc 180 ctggcctatc tttccttcat tgatgcctgc tattcttctg tcaataaccc taaactgatt 240 gtagattcac tccgtgaaaa gaagaccacc acattcaatg catgtataac ccaaatcttt 300 ggggaacatt tttttggagg tgctgatgtc atcctgctta ctgtgatggc ctatgaccgc 360 tatgtggcca tctgcaagcc actgcactac atgaccatca tgaatcggca ggtgtgtggc 420 ttgctcatgg cagtggtgtg ggtgggaggc tttcttcatg cagccataca gatcctcttt 480 atcatccctc tacccttctg tggccctaac gtcatagatc actttatgtg tgatctgaat 540 cctatgctca atcttgcctg cactgatacc cacactcttg ggttctttgt tgctgccaac 600 agtggtttca tctgtgcctt aaacttcctc ctcctcatgg tctcctatgt ggtcattctg 660

Page 594

069269_0225_SL.TXT cgctccctaa ggaaccacag cttggaggcg aagcgcaaag ccctctccac ctgtgtctcc cacatcacag tggtcgtcct attctttgtg ccctgcatat ttgtgtacat gagacccgca gctactttac ctattgataa agcagttgca gttttctaca ctatgataac acccatgtta aatcccttaa tctatgcctt gagaaatgat cagatgcaaa aagccattag gaaattgtgc agtagaaaag ttatttcaga tgagaaataa

720

780

840

900

930 <210> 536 <211> 309 <212> PRT <213> Canis familiaris <400> 536

Met Gly 1 Asn Arg Asn Asn Val Thr Glu Phe Val Leu Leu Gly Leu 15 Thr 5 10 Glu Asn Pro Lys Met Gln Lys Ile Val Phe Val Val Phe Leu Ile Ile 20 25 30 Tyr Ile Ile Ser Val Val Gly Asn Val Leu Thr Val Ala Ala Ile Thr 35 40 45 Thr Ser Pro Leu Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu 50 55 60 Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Asn Asn Pro Lys Leu Ile 65 70 75 80 Val Asp Ser Leu Arg Glu Lys Lys Thr Thr Thr Phe Asn Ala Cys Ile 85 90 95 Thr Gln Ile Phe Gly Glu His Phe Phe Gly Gly Ala Asp Val Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Arg Gln Val Cys Gly Leu Leu Met Ala 130 135 140

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Val Val Trp Val Gly Gly Phe Leu His Ala Ala Ile Gln Ile Leu Phe 145 150 155 160 Ile Ile Pro Leu Pro Phe 165 Cys Gly Pro Asn Val Ile 170 Asp His Phe Met 175 Cys Asp Leu Asn Pro Met 180 Leu Asn Leu Ala Cys Thr 185 Asp Thr His Thr 190 Leu Gly Phe Phe Val Ala 195 Ala Asn 200 Ser Gly Phe Ile Cys Ala Leu Asn 205 Phe Leu 210 Leu Leu Met Val Ser Tyr 215 Val Val Ile Leu 220 Arg Ser Leu Arg Asn His 225 Ser Leu Glu Ala 230 Lys Arg Lys Ala Leu Ser 235 Thr Cys Val Ser 240 His Ile Thr Val Val Val 245 Leu Phe Phe Val Pro Cys 250 Ile Phe Val Tyr 255 Met Arg Pro Ala Ala Thr 260 Leu Pro Ile Asp Lys Ala 265 Val Ala Val Phe 270 Tyr Thr Met Ile Thr Pro 275 Met Leu 280 Asn Pro Leu Ile Tyr Ala Leu Arg 285 Asn Asp Gln Met Gln Lys 290 Ile Ser Asp Glu Lys 305 <210> 537 <211> 921 <212> DNA <213> Canis familiaris <400> 537 Ala Ile 295 Arg Lys Leu Cys 300 Ser Arg Lys Val atgacaagcc agagaaacat ctccgaattc atacttctag gactttcaaa tgaccagagc 60

Page 596

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atacagatat tttgttttgt cattttctta ctctgttatg ttgctctgtt ggcaggaaat 120 cttctgatcc ttatctccat tcgatgcagc cctctttttc accaaccaat gtactatttc 180 cttatacact tatccttaat agacatctgc tacacctcta cagttacacc caagttaatt 240 ggtgacttgc tagtggaaag gaaaaccatc tcctatgaca attgcatgtt acaggtcttt 300 acaatgcact tctttggagg cattgagatc ttcattctca ccgccatggc ctttgatcgc 360 tatgctgcca tctgcaaacc tctccactac gtgattatca tgaacaggac aagatgcaat 420 ctcctagtct tagctgcttg ggctggtggg gccattcatg cctttccttt actttctact 480 gcaattggtt tgcccttcta tggtcctaat gaaattgatc actacttttg tgatattttt 540 cctttgctta aagtggcctg tactgatact tacatcacta gtgtccttgt gattgccctt 600 tcaggaatgg tcacattagt tacctttatt gtcttatctg tttcttatgg tattgttcac 660 tttaagaaat ctctcagctg aaggaagacg caaagccctc tctacctgtt ggtctcatat 720 cactgtggtc atctatattt tgggcctgta gtctttatgt accttaggcc acttattact 780 tttcctgagg acaaaatatt tgctatgttt tacaccatca ttgctccttt gttcaattcc 840 ttaatctatt ctctgagaaa ttcagagatg aaaaaagcca tgaggaaagt ttggtgtcca 900 tcagtatttt caaaggaagc a 921

<210> 538 <211> 226 <212> PRT <213> Canis familiaris <400> 538

Met Thr Ser Gln Arg Asn Ile Ser Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15 Asn Asp Gln Ser Ile Gln Ile Phe Cys Phe Val Ile Phe Leu Leu Cys 20 25 30 Tyr Val Ala Leu Leu Ala Gly Asn Leu Leu Ile Leu Ile Ser Ile Arg 35 40 45 Cys Ser Pro Leu Phe His Gln Pro Met Tyr Tyr Phe Leu Ile His Leu 50 55 60

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Ser Leu 65 Ile Asp Ile Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Ile 80 70 75 Gly Asp Leu Leu Val Glu Arg Lys Thr Ile Ser Tyr Asp Asn Cys Met 85 90 95 Leu Gln Val Phe Thr Met His Phe Phe Gly Gly Ile Glu Ile Phe Ile 100 105 110 Leu Thr Ala Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Val Ile Ile Met Asn Arg Thr Arg Cys Asn Leu Leu Val Leu 130 135 140 Ala Ala Trp Ala Gly Gly Ala Ile His Ala Phe Pro Leu Leu Ser Thr 145 150 155 160 Ala Ile Gly Leu Pro Phe Tyr Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Ile Phe Pro Leu Leu Lys Val Ala Cys Thr Asp Thr Tyr Ile 180 185 190 Thr Ser Val Leu Val Ile Ala Leu Ser Gly Met Val Thr Leu Val Thr 195 200 205 Phe Ile Val Leu Ser Val Ser Tyr Gly Ile Val His Phe Lys Lys Ser 210 215 220

Leu Ser 225 <210> 539 <211> 210 <212> DNA <213> Canis familiaris <400> 539

Page 598

069269_0225_SL.TXT gtggtggtgg cagccttttc tgttgtcttg gtggcttctt acatattcat atcacataat 60 cttaggaccc actcctccgc cgggtaatgc aaagctctct ccacctgcag ctctcatgta 120 atggtggtag ttttattctt catgccctgt atctgtactt aggttctacc tgcagggagt 180 gagaacagag atgaggaact ctccatattt 210 <210> 540 <211> 39 <212> PRT <213> Canis familiaris <400> 540

Trp Trp Trp Gln Pro Phe Leu Leu Ser Trp Trp Leu Leu Thr Tyr Ser 1 5 10 15 Tyr His Ile Ile Leu Gly Pro Thr Pro Pro Pro Gly Asn Ala Lys Leu 20 25 30 Ser Pro Pro Ala Ala Leu Met 35

<210> 541 <211> 912 <212> DNA <213> Canis familiaris <400> 541

atggagagcc agaggaatgt ctcagaattc attcttttgg gactttcgca tgaccagaac 60 atgcaaatat tttgctttgt gctcttctta ttctgttatg ctgctctctt ggtaggaaac 120 cttctgatcc ttgtctctat tcgatgcagc cctctttttc accaaccgat gtactacttc 180 ctcagccact tatccacttt ggacatctgc tatacctcta gcgttacacc caaattaatt 240 gctgacctgc tagtggaaag aaaagccatc tcctatggta attgtatgtt acaggtcttt 300 gccatgcact tctttggaac gattgaggtt ttaatcctta cagtcatggc ctttgatcgc 360 tatgctgcca tctgcaaacc tctccactac ctgcttatca tgaacaggac aaggtgtaat 420 ctcctagtct tagctgcttg ggctggtggg gctgtccact cctttcctca attttgtatg 480 gtaatcaggt tgcccttctg tgggcctaat gagattgatc actatttctg tgatatattt 540 cctttgctaa aggttgcctg cactgatacc tacatcactg gtgtccttat ggttgccaat 600

Page 599

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tcgggaatgg ttaccttggt gacatttgtg gttttatttt tttcttatgt cattatatta 660 ttcactttaa gaaatcactc agcggaagga agacgcaaag ccctctctac ctgtggatct 720 cacatcacag ttatagtttt attttttggg ccttccatct ttgcctacct tagacctcca 780 accaatttcc ctgaggataa aatatttgct ctgttttaca ccatcattgc tcctatgttc 840 aatcccttaa tctatactct gagaaattca gagatgaaaa atgccatgag aaaattttgg 900 tgtcaaacat ga 912

<210> 542 <211> 303 <212> PRT <213> Canis familiaris <400> 542

Met Glu Ser Gln Arg Asn Val Ser Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15 His Asp Gln Asn Met Gln Ile Phe Cys Phe Val Leu Phe Leu Phe Cys 20 25 30 Tyr Ala Ala Leu Leu Val Gly Asn Leu Leu Ile Leu Val Ser Ile Arg 35 40 45 Cys Ser Pro Leu Phe His Gln Pro Met Tyr Tyr Phe Leu Ser His Leu 50 55 60 Ser Thr Leu Asp Ile Cys Tyr Thr Ser Ser Val Thr Pro Lys Leu Ile 65 70 75 80 Ala Asp Leu Leu Val Glu Arg Lys Ala Ile Ser Tyr Gly Asn Cys Met 85 90 95 Leu Gln Val Phe Ala Met His Phe Phe Gly Thr Ile Glu Val Leu Ile 100 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Lys Pro Leu 115 120 125

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His Tyr 130 Leu Leu Ile Met Asn Arg 135 Thr Arg Cys Asn Leu Leu Val 140 Leu Ala Ala 145 Trp Ala Gly Gly Ala Val 150 His Ser Phe Pro Gln Phe Cys 155 Met 160 Val Ile Arg Leu Pro Phe Cys Gly 165 Pro Asn Glu Ile Asp His Tyr 170 175 Phe Cys Asp Ile Phe Pro Leu Leu Lys 180 Val Ala Cys Thr Asp Thr Tyr 185 190 Ile Thr Gly Val Leu Met Val Ala Asn 195 200 Ser Gly Met Val Thr Leu Val 205 Thr Phe Val 210 Val Leu Phe Phe Ser Tyr 215 Val Ile Ile Leu Phe Thr Leu 220 Arg Asn His 225 Ser Ala Glu Gly Arg Arg 230 Lys Ala Leu Ser Thr Cys Gly 235 Ser 240 His Ile Thr Val Ile Val Leu Phe 245 Phe Gly Pro Ser Ile Phe Ala 250 255 Tyr Leu Arg Pro Pro Thr Asn Phe Pro 260 Glu Asp Lys Ile Phe Ala Leu 265 270 Phe Tyr Thr Ile Ile Ala Pro Met Phe 275 280 Asn Pro Leu Ile Tyr Thr Leu 285 Arg Asn Ser Glu Met Lys Asn Ala Met 290 295 <210> 543 <211> 930 <212> DNA <213> Canis familiaris <400> 543 Arg Lys Phe Trp Cys Gln Thr 300 atggaaaatc agaacaatgt cacagaattt gttttcatgg gtttgtgggg aaataaacaa

Page 601

069269_0225_SL.TXT

atggagctac tgttcttttt cctgttcctg ctctgttatt tggccatctt aatgggaaac 120 ttcatcatct tactcacgat catctgcagc catctaattg aacaaccaat gtactacttt 180 ctctgccacc tttctctcat ggacctctgc tacacttcca ctgtagtccc cagactaatc 240 agggacttag gtgcagccag aaaaaacatt tcctataaca actgtatgac ccagctcttc 300 actgcccact tgctggcagg ggtggagata ttcatcttgg tgtccatggc tttagaccgt 360 tatgtggcca ttgtcaagcc cctgcattac atggtcatca tgagccggcg gaggtgtaac 420 ctgttgattt tcatggcctg gagtgtgggg ttttggcact ctgttgctct attgctcttg 480 gtactcaatt tacctttctg tggtcctaat cagataaatc attacatatg tgatgtgaag 540 cctcttttga aactggtgtg cagagatatt cgtgttgtta atatcttagt gatttcaaac 600 tcaggaatgg tggtggttgc tgtgtttctt gtcctggtgg cttcttacat tctcatatta 660 tacaatctga ggacccactc ctctgtaggg agacgcaaag ctctctccac gtgcagctct 720 catgtaatgg tggtcatttt attctttgtg ccttgtatct atatttatgt tctacctgca 780 gggagtgaaa acaaggataa ggagatctct gtgttttaca ctgtgattgc tcccttattg 840 aatcctctca tctataccct gagaaacatg gagatgagaa atgccatgtg gaaggtgtgg 900 tctaaaatgg cacatacgaa attcaggtaa 930

<210> 544 <211> 309 <212> PRT <213> Canis familiaris <400> 544

Met Glu Asn Gln Asn Asn Val Thr Glu Phe Val Phe Met Gly Leu Trp 1 5 10 15 Gly Asn Lys Gln Met Glu Leu Leu Phe Phe Phe Leu Phe Leu Leu Cys 20 25 30 Tyr Leu Ala Ile Leu Met Gly Asn Phe Ile Ile Leu Leu Thr Ile Ile 35 40 45 Cys Ser His Leu Ile Glu Gln Pro Met Tyr Tyr Phe Leu Cys His Leu 50 55 60

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Ser 65 Leu Met Asp Leu Cys Tyr Thr Ser Thr Val Val Pro Arg Leu Ile 70 75 80 Arg Asp Leu Gly Ala Ala Arg Lys Asn Ile Ser Tyr Asn Asn Cys Met 85 90 95 Thr Gln Leu Phe Thr Ala His Leu Leu Ala Gly Val Glu Ile Phe Ile 100 105 110 Leu Val Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Val Lys Pro Leu 115 120 125 His Tyr Met Val Ile Met Ser Arg Arg Arg Cys Asn Leu Leu Ile Phe 130 135 140 Met Ala Trp Ser Val Gly Phe Trp His Ser Val Ala Leu Leu Leu Leu 145 150 155 160 Val Leu Asn Leu Pro Phe Cys Gly Pro Asn Gln Ile Asn His Tyr Ile 165 170 175 Cys Asp Val Lys Pro Leu Leu Lys Leu Val Cys Arg Asp Ile Arg Val 180 185 190 Val Asn Ile Leu Val Ile Ser Asn Ser Gly Met Val Val Val Ala Val 195 200 205 Phe Leu Val Leu Val Ala Ser Tyr Ile Leu Ile Leu Tyr Asn Leu Arg 210 215 220 Thr His Ser Ser Val Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Val Met Val Val Ile Leu Phe Phe Val Pro Cys Ile Tyr Ile Tyr 245 250 255 Val Leu Pro Ala Gly Ser Glu Asn Lys Asp Lys Glu Ile Ser Val Phe 260 265 270

Page 603

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Tyr Thr Val Ile Ala Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Met Glu Met Arg Asn Ala Met Trp Lys Val Trp Ser Lys Met Ala 290 295 300 His Thr Lys Phe Arg 305

<210> 545 <211> 858 <212> DNA <213> Canis familiaris <400> 545

atgcagcaaa ataacagtac tactgagttc atactgttag gattgaccca agatcctatg 60 aaaaagaaaa cggtatttgt aatatttttc attttttatt tgggaactgt ggttgggaat 120 ttgcttatta ttgtgaccat caagtccagc cggacacttg ggagccccat gtactatttc 180 ttattttatt tgtcccttgc tgattcctgc ttttcaactt ccacagcccc caaactaatt 240 gtggattcac tctctgcaaa aaatatcata acttacaatg aatgcatgac tcaagtcttt 300 gcactgcatt tctttggttg catggaggtt tttgtcctcc tcctcatggc ctttgaccgg 360 tatgtggcca tctgtaagcc cttacattac acaaccatca tgagccggcg ggtttgcacc 420 atcctaattg ttctggcatg gattggatct tttatccatt ctacagccca gattatcctg 480 gctttgagat tgcccttctg tggaccccac ctactgttgg tttctaatag tggggccatt 540 tgctcaagca gttttgtgat tctgatgatc tcctacattg tcatcttgca ttccctgcga 600 aaccacagtg cagaagggag gaaaaaagct ctctctactt gcacttctca catcatcgta 660 gtagtcttat gctttggtcc ctgtatattc acatatacac gccccccaac cacttacccc 720 atggacaaga tgatggccgt gttttatact attgggacac cgcttgttaa cccactcatc 780 tacacactga ggaatgcaga agtgaaaaat gccatgcaaa agctatggca tatcaaaatt 840 acctcagaaa gcagaaga 858

<210> 546 <211> 286

Page 604

069269_0225_SL.TXT <212> PRT <213> Canis familiaris <400> 546

Met Gln Gln Asn Asn Ser Thr Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Gln Asp Pro Met Lys Lys Lys Thr Val Phe Val Ile Phe Phe Ile Phe 20 25 30 Tyr Leu Gly Thr Val Val Gly Asn Leu Leu Ile Ile Val Thr Ile Lys 35 40 45 Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Tyr Phe Leu Phe Tyr Leu 50 55 60 Ser Leu Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Lys Leu Ile 65 70 75 80 Val Asp Ser Leu Ser Ala Lys Asn Ile Ile Thr Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Leu His Phe Phe Gly Cys Met Glu Val Phe Val 100 105 110 Leu Leu Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Ser Arg Arg Val Cys Thr Ile Leu Ile Val 130 135 140 Leu Ala Trp Ile Gly Ser Phe Ile His Ser Thr Ala Gln Ile Ile Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro His Leu Leu Leu Val Ser Asn 165 170 175 Ser Gly Ala Ile Cys Ser Ser Ser Phe Val Ile Leu Met Ile Ser Tyr 180 185 190

Page 605

Ile Val Ile 195 Leu His Ser Leu 069269_0225_SL.TXT Arg Asn His Ser Ala Glu 200 205 Gly Arg Lys Lys Ala Leu Ser Thr Cys Thr Ser His Ile Ile Val Val Val Leu Cys 210 215 220 Phe Gly Pro Cys Ile Phe Thr Tyr Thr Arg Pro Pro Thr Thr Tyr Pro 225 230 235 240 Met Asp Lys Met Met Ala Val Phe Tyr Thr Ile Gly Thr Pro Leu Val 245 250 255 Asn Pro Leu Ile Tyr Thr Leu Arg Asn Ala Glu Val Lys Asn Ala Met 260 265 270 Gln Lys Leu Trp His Ile Lys Ile Thr Ser Glu Ser Arg Arg 275 280 285

<210> 547 <211> 930 <212> DNA <213> Canis familiaris <400> 547

atggagatta ggaacaacgt gacagaattt gtgctactgg ggctcacaga gaatccaaag 60 atgcagaaaa tcatatttgt tgtgtttctg gtcatctaca tcgtctctgt ggtaggaaat 120 gtgctcaccg tggtcactat cactgccagc ccattatcgg ggtcccccat gtactttttc 180 ctggcctatc tctccctcat tgatgcctgc tattcttctg tcaatacccc caccctcatc 240 atagagtcac tccgtgaaaa gaagaccatc ccattcaatg catgcataat ccaaatcttt 300 ggggaacatt tctttggagg tgctgatgtc atcctgctta ctgtgatggc ctatgaccgc 360 tatgtggcca tctgcaagcc actgcactac atgaccatca tgaatcggcg gctatgtggc 420 ctgctcatgg cagtggtgtg ggtgggaggc tttcttcatg cagccataca gatcctcttt 480 atcatcccac tacccttctg tggccctaac gtcatagatc actttatatg tgatctgaat 540 cctttgctca atcttgcctg cactgatacc cacactcttg ggttctttgt tgctgccaac 600 agtggtttca tctgtgtctt aaacttcctc ctcctcatgg tttcctatgt ggtcattctg 660

Page 606

069269_0225_SL.TXT cgctccctaa agaaccacag cttggaggcg aggcgcaaag ccctctccac ctgtgtctct cacatcacag tggtcgtcct attctttgtg ccctgcatat ttgtgtacat gagacccgca gctactttat ccattgataa agcagttgca gtgttctata ctacaataac tcccatgtta aatcctttaa tctatacctt gagaaatgac cagatgaaaa atgccattag gaaactgtgt agtaggaatg ctagtgtggg tgacaaataa

720

780

840

900

930 <210> 548 <211> 309 <212> PRT <213> Canis familiaris <400> 548

Met Glu Ile 1 Arg Asn Asn Val Thr 5 Glu Phe Val Leu Leu Gly Leu Thr 10 15 Glu Asn Pro Lys Met Gln Lys Ile Ile Phe Val Val Phe Leu Val Ile 20 25 30 Tyr Ile Val Ser Val Val Gly Asn Val Leu Thr Val Val Thr Ile Thr 35 40 45 Ala Ser Pro Leu Ser Gly Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu 50 55 60 Ser Leu Ile Asp Ala Cys Tyr Ser Ser Val Asn Thr Pro Thr Leu Ile 65 70 75 80 Ile Glu Ser Leu Arg Glu Lys Lys Thr Ile Pro Phe Asn Ala Cys Ile 85 90 95 Ile Gln Ile Phe Gly Glu His Phe Phe Gly Gly Ala Asp Val Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Arg Arg Leu Cys Gly Leu Leu Met Ala 130 135 140

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Val Val Trp Val Gly Gly Phe Leu His Ala Ala Ile Gln Ile Leu Phe 145 150 155 160 Ile Ile Pro Leu Pro Phe 165 Cys Gly Pro Asn Val Ile 170 Asp His Phe Ile 175 Cys Asp Leu Asn Pro Leu 180 Leu Asn Leu Ala Cys Thr 185 Asp Thr His Thr 190 Leu Gly Phe Phe Val Ala 195 Ala Asn 200 Ser Gly Phe Ile Cys Val Leu Asn 205 Phe Leu 210 Leu Leu Met Val Ser Tyr 215 Val Val Ile Leu 220 Arg Ser Leu Lys Asn His 225 Ser Leu Glu Ala 230 Arg Arg Lys Ala Leu Ser 235 Thr Cys Val Ser 240 His Ile Thr Val Val Val 245 Leu Phe Phe Val Pro Cys 250 Ile Phe Val Tyr 255 Met Arg Pro Ala Ala Thr 260 Leu Ser Ile Asp Lys Ala 265 Val Ala Val Phe 270 Tyr Thr Thr Ile Thr Pro 275 Met Leu 280 Asn Pro Leu Ile Tyr Thr Leu Arg 285 Asn Asp Gln Met Lys Asn 290 Ser Val Gly Asp Lys 305 <210> 549 <211> 933 <212> DNA <213> Canis familiaris <400> 549 Ala Ile 295 Arg Lys Leu Cys 300 Ser Arg Asn Ala atgcagcaaa ataacagtac tactgagttc atactgttag gattgactca agatcctatg 60

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aaaaagaaaa tggtatttgt aatatttttc attttttatt tgggaactgt ggttgggaat 120 ttgcttatta ttgtaaccat caagtccagc cggacacttg ggagccccat gtactatttc 180 ttattttatt tgtcccttgc tgattcctgc ttctcaactt ccacagcccc aagactaatt 240 gtggattcac tctctgcaaa aaatatcata acttacaatg aatgcatgac tcaagtcttt 300 gcactgcatt tctttggctg catggaggtt ttagtcctca tccttatggc ctttgaccgg 360 tatgtggcca tctgtaagcc cttacattac ccaaccatca tgagccggcg ggtctgcacc 420 atcctaattg ttctggcatg gattggatct tttatccatt ctacagccca gattatcctg 480 gctttgagat tgcccttctg tggacccaat ttgattgatc attactgctg tgatttgcag 540 cccttgctga aacttgcttg catggacact tttgtgatca acctactgtt ggtgtctaat 600 agcgggggca tttcctcaag cagttttgtg attctgatga tctcctacat tgtcatcttg 660 cattcactgc gaaaccacag tgcggaaggg aggaaaaaag ctctctctac ttgcactact 720 cacatcattg tagtaatcat attctttggt ccctgtatat tcatttatac acgcccccca 780 accacttacc ccatggacaa gatggtaact gtattttata ctattgggac accttttctc 840 aacccactta tctacacact gaggaatgca gaagtgaaaa atgccatgag aaagctatgg 900 catatcaata ttacctcaga aagcagaaga tga 933

<210> 550 <211> 310 <212> PRT <213> Canis familiaris <400> 550

Met 1 Gln Gln Asn Asn Ser Thr Thr Glu Phe Ile Leu Leu Gly Leu Thr 5 10 15 Gln Asp Pro Met Lys Lys Lys Met Val Phe Val Ile Phe Phe Ile Phe 20 25 30 Tyr Leu Gly Thr Val Val Gly Asn Leu Leu Ile Ile Val Thr Ile Lys 35 40 45 Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Tyr Phe Leu Phe Tyr Leu

50 55 60

Page 609

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Ser 65 Leu Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile 70 75 80 Val Asp Ser Leu Ser Ala Lys Asn Ile Ile Thr Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Leu His Phe Phe Gly Cys Met Glu Val Leu Val 100 105 110 Leu Ile Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Pro Thr Ile Met Ser Arg Arg Val Cys Thr Ile Leu Ile Val 130 135 140 Leu Ala Trp Ile Gly Ser Phe Ile His Ser Thr Ala Gln Ile Ile Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Leu Ile Asp His Tyr Cys 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Phe Val 180 185 190 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Gly Ile Ser Ser Ser Ser 195 200 205 Phe Val Ile Leu Met Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Lys Lys Ala Leu Ser Thr Cys Thr Thr 225 230 235 240 His Ile Ile Val Val Ile Ile Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Pro Thr Thr Tyr Pro Met Asp Lys Met Val Thr Val Phe 260 265 270

Page 610

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Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp His Ile Asn Ile 290 295 300 Thr Ser Glu Ser Arg Arg 305 310

<210> 551 <211> 918 <212> DNA <213> Canis familiaris <400> 551

atggagagag gcaatcatac agtgactgag ttcatcctgg tgggcttcac gacagaccca 60 gtgatgcagc tggtcctgtt tgtggtattc cttggcgtgt actctctgac tgtggtagca 120 aatgccaccc tcatagtttt gatctgtaat gactcccggc tgcacacacc catgtatttt 180 ttcattggga atctatcttt tctggatctc tggtattcct ctgtctacac tccgaaaatc 240 ctcatgacct gcatctctga agacaaaagc atctcctttg ctggctgtgt atgtcagttc 300 ttcttctctg cagggctggc atatactgag tgttacctgt tggctgccat ggcttatgac 360 cgctatatgg ccatctcaaa gccactgcgc tatgctcagg ccatgtctat aaagctgtgt 420 gcatttttgg tagcatcctc atatcttggt gcttttatta actcttctat catcaccaaa 480 agaacttttg ccttagactt ctgtagtggc aatgttattg atgacttttt ttgtgatttg 540 ctgcccctgg tgaagttggc ttgtggcaga aaagatggct accaggctat actgtacttc 600 cttctggcct ccaatgtcat cacccctaca gtgctcatcc tagcctccta cctgttcatc 660 attggcgcca tcttgaggat ccgctccacc cagggccgcc tcaaagcctt ctctacatgt 720 tcctcacacc tggtctctgt caccttgtac tatggctcca ttctctacat ctactctcgt 780 ccccgatcta gctattcttt ggacacagac aaaatagttt ccacatttta tactgtggtg 840 ttccccatgc tgaatcctat gatctatagc ctgaggaata aggatgtgaa agaggctctg 900 aataaactca ttaaataa 918

Page 611

069269_0225_SL.TXT <210> 552 <211> 305 <212> PRT <213> Canis familiaris <400> 552

Met 1 Glu Arg Gly Asn His Thr Val Thr Glu Phe Ile Leu Val Gly Phe 5 10 15 Thr Thr Asp Pro Val Met Gln Leu Val Leu Phe Val Val Phe Leu Gly 20 25 30 Val Tyr Ser Leu Thr Val Val Ala Asn Ala Thr Leu Ile Val Leu Ile 35 40 45 Cys Asn Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Ile Gly Asn 50 55 60 Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val Tyr Thr Pro Lys Ile 65 70 75 80 Leu Met Thr Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys 85 90 95 Val Cys Gln Phe Phe Phe Ser Ala Gly Leu Ala Tyr Thr Glu Cys Tyr 100 105 110 Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Met Ala Ile Ser Lys Pro 115 120 125 Leu Arg Tyr Ala Gln Ala Met Ser Ile Lys Leu Cys Ala Phe Leu Val 130 135 140 Ala Ser Ser Tyr Leu Gly Ala Phe Ile Asn Ser Ser Ile Ile Thr Lys 145 150 155 160 Arg Thr Phe Ala Leu Asp Phe Cys Ser Gly Asn Val Ile Asp Asp Phe 165 170 175 Phe Cys Asp Leu Leu Pro Leu Val Lys Leu Ala Cys Gly Arg Lys Asp

Page 612

180

069269_0225_SL.TXT 185 190

Gly Tyr Gln Ala Ile Leu 195 Tyr Phe Leu Leu Ala Ser Asn Val Ile Thr 200 205 Pro Thr Val Leu Ile Leu Ala Ser Tyr Leu Phe Ile Ile Gly Ala Ile 210 215 220 Leu Arg Ile Arg Ser Thr Gln Gly Arg Leu Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Val Ser Val Thr Leu Tyr Tyr Gly Ser Ile Leu Tyr 245 250 255 Ile Tyr Ser Arg Pro Arg Ser Ser Tyr Ser Leu Asp Thr Asp Lys Ile 260 265 270 Val Ser Thr Phe Tyr Thr Val Val Phe Pro Met Leu Asn Pro Met Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Asn Lys Leu Ile 290 295 300

Lys

305 <210> 553 <211> 933 <212> DNA <213> Canis familiaris <400> 553

atgcagcaaa ataacagaac tactgagttc atactgttag gattgactca agatcctatg 60 aaaaagaaaa tggtatttgt aatatttttc attttttatt tgggaactgt ggttgggaat 120 ttgcttatta ttgtaaccat caagtccagc cggacacttg ggagccccat gtactatttc 180 ttattttatt tgtcccttgc tgattcctgc ttctcaactt ccacagcccc aagactaatt 240 gtggattcac tctctgcaaa aaatatcata acttacaatg aatgcatgac tcaagtcttt 300 gcactgcatt tctttggctg catggaggtt ttagtcctca tccttatggc ctttgaccgg 360

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tatgtggcca tctgtaagcc cttacattac ccaaccatca tgagccggcg ggtctgcacc 420 atcctaattg ttctggcatg gattggatct tttatccatt ctacagccca gattatcctg 480 gctttgagat tgcccttctg tggacccaat ttgattgatc attactgctg tgatttgcag 540 cccttgctga aacttgcttg catggacact tttgtgatca acctactgtt ggtgtctaat 600 agcgggggca tttcctcaag cagttttgtg attctgatga tctcctacat tgtcatcttg 660 cattcactgc gaaaccacag tgcggaaggg aggaaaaaag ctctctctac ttgcactact 720 cacatcattg tagtaatcat attctttggt ccctgtatat tcatttatac acgcccccca 780 accacttacc ccatggacaa gatggtaact gtattttata ctattgggac accttttctc 840 aacccactta tctacacact gaggaatgca gaagtgaaaa atgccatgag aaagctatgg 900 catatcaata ttacctcaga aagcagaaga tga 933

<210> 554 <211> 310 <212> PRT <213> Canis familiaris <400> 554

Met Gln Gln Asn Asn Arg Thr Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Gln Asp Pro Met Lys Lys Lys Met Val Phe Val Ile Phe Phe Ile Phe 20 25 30 Tyr Leu Gly Thr Val Val Gly Asn Leu Leu Ile Ile Val Thr Ile Lys 35 40 45 Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Tyr Phe Leu Phe Tyr Leu 50 55 60 Ser Leu Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ser Leu Ser Ala Lys Asn Ile Ile Thr Tyr Asn Glu Cys Met 85 90 95

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Thr Gln Val Phe 100 Ala Leu His Phe Phe Gly Cys Met Glu Val Leu Val 105 110 Leu Ile Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Pro Thr Ile Met Ser Arg Arg Val Cys Thr Ile Leu Ile Val 130 135 140 Leu Ala Trp Ile Gly Ser Phe Ile His Ser Thr Ala Gln Ile Ile Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Leu Ile Asp His Tyr Cys 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Phe Val 180 185 190 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Gly Ile Ser Ser Ser Ser 195 200 205 Phe Val Ile Leu Met Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Lys Lys Ala Leu Ser Thr Cys Thr Thr 225 230 235 240 His Ile Ile Val Val Ile Ile Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Pro Thr Thr Tyr Pro Met Asp Lys Met Val Thr Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp His Ile Asn Ile 290 295 300

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Thr Ser Glu Ser Arg Arg 305 310 <210> 555 <211> 933 <212> DNA <213> Canis familiaris <400> 555

atgcagcaaa ataacagtac tactgagttc atactgttag gattgaccca agatcctatg 60 aaaaagaaaa cggtatttgt aatatttttc attttttatt tgggaactgt ggttgggaat 120 ttgcttatta ttgtgaccat caagtccagc cggacacttg ggagccccat gtactatttc 180 ttattttatt tgtcccttgc tgattcctgc ttttcaactt ccacagcccc aagactaatt 240 gtggattcac tctctgcaaa aaatatcata acttacaatg aatgcatgac tcaagtcttt 300 gcactgcatt tctttggttg catggaggtt tttgtcctcc tcctcatggc ctttgaccgg 360 tatgtggcca tctgtaagcc cttacattac ccaaccatca tgagccggcg ggtttgcacc 420 atcctaattg ttctggcatg ggttggatct tttatccatt ctatagccca gattatcctg 480 gctttgagat tgcccttctg tggacccaat ttgattgatc attactgctg tgatttgcag 540 cccttgctga aacttgcttg catggacact tataagatca acctactgtt ggtttctaat 600 agtggggcca tttgctcaag cagttttgtg attctgatga tctcctacat tgtcatcttg 660 cattccctgc gaaaccacag tgcagaaggg aggaaaaaag ctctctctac ttgcacttct 720 cacatcatcg tagtagtctt atgctttggt ccctgtatat tcacatatac acgcccccca 780 accacttacc ccatggacaa gatgatggcc gtgttttata ctattgggac accgcttgtc 840 aacccactca tctacacact gaggaatgca gaagtgaaaa atgccatgca aaagctatgg 900 catatcaaaa ttacctcaga aagcagaaga tga 933

<210> 556 <211> 310 <212> PRT <213> Canis familiaris <400> 556

Met Gln Gln Asn Asn Ser Thr Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15

Page 616

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Gln Asp Pro Met Lys Lys Lys Thr Val Phe Val Ile Phe Phe Ile Phe 20 25 30 Tyr Leu Gly Thr Val Val Gly Asn Leu Leu Ile Ile Val Thr Ile Lys 35 40 45 Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Tyr Phe Leu Phe Tyr Leu 50 55 60 Ser Leu Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ser Leu Ser Ala Lys Asn Ile Ile Thr Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Leu His Phe Phe Gly Cys Met Glu Val Phe Val 100 105 110 Leu Leu Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Pro Thr Ile Met Ser Arg Arg Val Cys Thr Ile Leu Ile Val 130 135 140 Leu Ala Trp Val Gly Ser Phe Ile His Ser Ile Ala Gln Ile Ile Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Leu Ile Asp His Tyr Cys 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Lys 180 185 190 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Ser Ser Ser 195 200 205 Phe Val Ile Leu Met Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220

Page 617

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Asn His 225 Ser Ala Glu Gly 230 Arg Lys Lys Ala Leu 235 Ser Thr Cys Thr Ser 240 His Ile Ile Val Val Val Leu Cys Phe Gly Pro Cys Ile Phe Thr Tyr 245 250 255 Thr Arg Pro Pro Thr Thr Tyr Pro Met Asp Lys Met Met Ala Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Leu Val Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Gln Lys Leu Trp His Ile Lys Ile 290 295 300 Thr Ser Glu Ser Arg Arg

305 310 <210> 557 <211> 933 <212> DNA <213> Canis familiaris <400> 557

atgcaacaaa ataacagcgt tactgagttc atactgttag gattgactca agatcctatg 60 aaaaagaaaa tggtatttat aatattcttc attttatata tgggaactgt ggtagggaat 120 ttgcttatta ttgtgaccat caggtttagt cggacacttg ggacccccat gtactatttc 180 ttattttatt tgtctcttgc ggattcctgc ttttcaactt ccacagcccc cagactaatt 240 gtggattcac tctctgcaaa aaaaatcata acttacaatg agtgtatgac tcaggtcttt 300 gcactacatt tctttggttg catggaggtc tttgtcctca tcctcatggc cattgatcgc 360 tatgtggcca tctgtaagcc cttacgttac ccaaccatca tgagccggca ggtctgcact 420 atcatgattg ttctcgcatg gataggatct tttttccatt ctatagccga ggttgtccca 480 gccttgagat tgcccttctg tggacccaat ttgattgatc attactgctg tgatttgcaa 540 cccttgctga aacttgcttg catggacact tatctgatta acctagaatg ggtgtctaat 600 agcggggcca tttgcacagg cagttttgtg attctgatga tctcctatat tgtcatcttg 660

Page 618

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cattcactga gaaactatag tgcagaaggg aagaaaaaag ctctctctac ttgcacttct 720 cacatcatcg tagtaatcat attctttggt ccgtgtatat tcacatacac acgcccccca 780 accacttacc ccatggacaa gatggtggct gtattttata ctattgggac accttttctc 840 aacccactca tctatacact gagaaatgca gaagtgaaaa atgccatgag aaagctatgg 900 cgtgtcaaaa ttacctcaga gagcagaaga tga 933

<210> 558 <211> 310 <212> PRT <213> Canis familiaris <400> 558

Met Gln Gln 1 Asn Asn Ser Val Thr 5 Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Gln Asp Pro Met Lys Lys Lys Met Val Phe Ile Ile Phe Phe Ile Leu 20 25 30 Tyr Met Gly Thr Val Val Gly Asn Leu Leu Ile Ile Val Thr Ile Arg 35 40 45 Phe Ser Arg Thr Leu Gly Thr Pro Met Tyr Tyr Phe Leu Phe Tyr Leu 50 55 60 Ser Leu Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ser Leu Ser Ala Lys Lys Ile Ile Thr Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Leu His Phe Phe Gly Cys Met Glu Val Phe Val 100 105 110 Leu Ile Leu Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Pro Thr Ile Met Ser Arg Gln Val Cys Thr Ile Met Ile Val 130 135 140

Page 619

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Leu 145 Ala Trp Ile Gly Ser 150 Phe Phe His Ser Ile Ala Glu Val Val Pro 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Leu Ile Asp His Tyr Cys 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Leu 180 185 190 Ile Asn Leu Glu Trp Val Ser Asn Ser Gly Ala Ile Cys Thr Gly Ser 195 200 205 Phe Val Ile Leu Met Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220 Asn Tyr Ser Ala Glu Gly Lys Lys Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Ile Ile Val Val Ile Ile Phe Phe Gly Pro Cys Ile Phe Thr Tyr 245 250 255 Thr Arg Pro Pro Thr Thr Tyr Pro Met Asp Lys Met Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp Arg Val Lys Ile 290 295 300 Thr Ser Glu Ser Arg Arg

305 310 <210> 559 <211> 936 <212> DNA <213> Canis familiaris <400> 559

Page 620

069269_0225_SL.TXT atggaaaaaa ggaataatgt aactgagttc attttctggg gtctttctca gaacctagag 60 gttgaagaag tttgtttcgt ggtgttttct ttcttctata cggtcattct tcttggcaac 120 ctcctcatca tgctgactgt ttacatgggc aaccttttca agtttcccat gtatttcttc 180 ctcaactact tgtcttttgt ggatatttgt tactcttcag tcacagctcc caagatgatt 240 gttgatctat tagccaagag caaaactatt tcctatgtcg ggtgcatgtt gcaactcttt 300 ggagtacatt tctttggttg cacagagatc ttcatcctta ctgtaatggc ctatgatcgt 360 tacgtggcta tctgtaaacc cctacactat accaccatca tggaccggaa cagatgcaat 420 aaaatgttgt tgggaacctg gataggaggg ttcttacact ccattatcca ggtggctctg 480 gtagttcagt tacccttttg tggacccagt gagatcgatc actacttttg tgatgtccac 540 cctgtgttga aacttgcctg cacagataca tatattgttg gtgttgtggt gacagccaac 600 agtggtacca ttgctctagg gagctttgtt atcttgataa tttcctatac tgtcatcctg 660 gtgtccctga gaaaacactc agcagaaggt aggcgcaaag cactctccac ctgtggctcc 720 cacattgctg tggtcataat cttttttggc ccatgtactt tcatgtacat gcgccctgat 780 actacctttt cagaggataa gatggtagct gtattttaca ccattatcac ccccatgtta 840 aatcctctga tctatacact cagaaatgca gaaataaaaa atacaataaa aagactgtgg 900 ggcaggaagg ttttctcaga ggctaacgat aaatag 936 <210> 560 <211> 311 <212> PRT <213> Canis familiaris <400> 560

Met 1 Glu Lys Arg Asn Asn Val Thr Glu Phe Ile Phe Trp Gly Leu Ser 5 10 15 Gln Asn Leu Glu Val Glu Glu Val Cys Phe Val Val Phe Ser Phe Phe 20 25 30 Tyr Thr Val Ile Leu Leu Gly Asn Leu Leu Ile Met Leu Thr Val Tyr 35 40 45 Met Gly Asn Leu Phe Lys Phe Pro Met Tyr Phe Phe Leu Asn Tyr Leu

Page 621

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50 55 60

Ser 65 Phe Val Asp Ile Cys Tyr Ser Ser Val Thr Ala Pro Lys Met Ile 70 75 80 Val Asp Leu Leu Ala Lys Ser Lys Thr Ile Ser Tyr Val Gly Cys Met 85 90 95 Leu Gln Leu Phe Gly Val His Phe Phe Gly Cys Thr Glu Ile Phe Ile 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Asp Arg Asn Arg Cys Asn Lys Met Leu Leu 130 135 140 Gly Thr Trp Ile Gly Gly Phe Leu His Ser Ile Ile Gln Val Ala Leu 145 150 155 160 Val Val Gln Leu Pro Phe Cys Gly Pro Ser Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Val His Pro Val Leu Lys Leu Ala Cys Thr Asp Thr Tyr Ile 180 185 190 Val Gly Val Val Val Thr Ala Asn Ser Gly Thr Ile Ala Leu Gly Ser 195 200 205 Phe Val Ile Leu Ile Ile Ser Tyr Thr Val Ile Leu Val Ser Leu Arg 210 215 220 Lys His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Ile Ala Val Val Ile Ile Phe Phe Gly Pro Cys Thr Phe Met Tyr 245 250 255 Met Arg Pro Asp Thr Thr Phe Ser Glu Asp Lys Met Val Ala Val Phe

Page 622

260

069269_0225_SL.TXT 265 270

Tyr Thr Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Ile Lys Asn Thr Ile Lys Arg Leu Trp Gly Arg Lys Val 290 295 300 Phe Ser Glu Ala Asn Asp Lys

305 310 <210> 561 <211> 900 <212> DNA <213> Canis familiaris <400> 561

ttgggacatg aaaatatcac agaatttaat ctcttgggac tttttagtga tgaggatgca 60 aaggccgcct gctttgtgct gttcgtactt tgctacattg caattctctc aggaaacttg 120 ctctatcttc tcacaatcag gggcagccgt ctccgtgaac agctcatgta ctttttcctg 180 agctacctat cttttatgga tgtctgcttc acttcagacc tactggccca gcagaagacc 240 atctcctaca atggctgcat ggcccagatg ttttatgccc atttttttgg tgccactgag 300 atcttcatct tggtggccat ggcctatgac cgatatgcag ccatctgcag accccttcac 360 tatatggtca tcatgagcag acaggtgtgc tatgtccttg taatggcctc aattctcgga 420 gcatttaccc attcaatcat gcaagtattg attgttattg aacttccctt ctgtggcccc 480 aatcagatag accactattt ctgtgatgtt ttccccttgc tgaagctggc ctgcatggat 540 actagcttgt tggttattgt gatcattact accacaggag tgctgtccat tttgaccttt 600 gttgccttgg taatttctta catcatcatc ctgtctaccc tgaggaccta ctcatcccag 660 ggctgccgca aagccctctc tacctgtggc tcacacatca ctgttgtgtt catgttcttc 720 ttgcctctca tcttcacata tgtccccatg gcggattccg tcagtaatga caaagtgttt 780 gccctatttt ataccatgat tgctcccatg ttcaaccctc tcatctacac attgagaaac 840 acagacatga agaatgccat gaggaaaatg tggtgccggg atgcacggtt tgaagggaaa 900

Page 623

069269_0225_SL.TXT <210> 562 <211> 300 <212> PRT <213> Canis familiaris <400> 562

Leu Gly His Glu Asn Ile Thr Glu Phe Asn Leu Leu Gly Leu Phe Ser 1 5 10 15 Asp Glu Asp Ala Lys Ala Ala Cys Phe Val Leu Phe Val Leu Cys Tyr 20 25 30 Ile Ala Ile Leu Ser Gly Asn Leu Leu Tyr Leu Leu Thr Ile Arg Gly 35 40 45 Ser Arg Leu Arg Glu Gln Leu Met Tyr Phe Phe Leu Ser Tyr Leu Ser 50 55 60 Phe Met Asp Val Cys Phe Thr Ser Asp Leu Leu Ala Gln Gln Lys Thr 65 70 75 80 Ile Ser Tyr Asn Gly Cys Met Ala Gln Met Phe Tyr Ala His Phe Phe 85 90 95 Gly Ala Thr Glu Ile Phe Ile Leu Val Ala Met Ala Tyr Asp Arg Tyr 100 105 110 Ala Ala Ile Cys Arg Pro Leu His Tyr Met Val Ile Met Ser Arg Gln 115 120 125 Val Cys Tyr Val Leu Val Met Ala Ser Ile Leu Gly Ala Phe Thr His 130 135 140 Ser Ile Met Gln Val Leu Ile Val Ile Glu Leu Pro Phe Cys Gly Pro 145 150 155 160 Asn Gln Ile Asp His Tyr Phe Cys Asp Val Phe Pro Leu Leu Lys Leu 165 170 175 Ala Cys Met Asp Thr Ser Leu Leu Val Ile Val Ile Ile Thr Thr Thr 180 185 190

Page 624

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Gly Val Leu Ser Ile Leu 195 Thr Phe Val Ala Leu Val Ile Ser Tyr Ile 200 205 Ile Ile Leu Ser Thr Leu Arg Thr Tyr Ser Ser Gln Gly Cys Arg Lys 210 215 220 Ala Leu Ser Thr Cys Gly Ser His Ile Thr Val Val Phe Met Phe Phe 225 230 235 240 Leu Pro Leu Ile Phe Thr Tyr Val Pro Met Ala Asp Ser Val Ser Asn 245 250 255 Asp Lys Val Phe Ala Leu Phe Tyr Thr Met Ile Ala Pro Met Phe Asn 260 265 270 Pro Leu Ile Tyr Thr Leu Arg Asn Thr Asp Met Lys Asn Ala Met Arg 275 280 285 Lys Met Trp Cys Arg Asp Ala Arg Phe Glu Gly Lys 290 295 300

<210> 563 <211> 933 <212> DNA <213> Canis familiaris <400> 563

atgcacctga ataataatgt gactgagttc attctgcttg gattgaccca ggatcctgtt 60 aggaaaaaaa tagtgtttgt cacttttttg tttttctatt tggggacatt gctgggtaac 120 tttctgatta ttactactat caagaccagc cagacactag ggagtccaat gtacttcttc 180 cttttccacc tatccttgtc tgacacctgc ttctgtactt ccatagcccc tagaatgatt 240 gttgatgcac ttttgaaaag ggccacaatc tctttcaggg agtgcatgat acaagtcttt 300 tcattccact tctttggctg cctggagatc ttcatcctta tcctcatggc tgctgaccgc 360 tatgtggcca tctgtaagcc cctgcactac acaaccatca tgagtcgaca ggtctgtgct 420 gtgctggtgg ctattgcctg ggtggggtcc tgtgtgcatt ctttagctca gatttttctg 480

Page 625

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gccctgagtt tacctttctg tggtcccaat gtgatcgatc actatcattg tgacttgcag 540 cccttgttga aacttgcctg tgcagatacc catgtgatca atctactgtt ggtatccaat 600 agtggggcca tttgtacact gagttttgtc atgctgatgt gctcctatgt tgtcatcttg 660 tattctctga gaaatcacag tgctgaaggg aggaggaaag ccctctccac ctgcatgtcc 720 cacatcattg tagtcgtctt gttctttggt ccttgcatat ttctatacac acgccctgca 780 accacctttc ccatggataa gatgatagct gtattttata cacttggaac acctttgatc 840 aatcctctga tttacacact taggaatgca gaagtgaaaa atgccatgaa gaagttatgg 900 aggaagaagt tgatttcaga tgacaaaaga tga 933

<210> 564 <211> 310 <212> PRT <213> Canis familiaris <400> 564

Met His 1 Leu Asn Asn 5 Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Gln Asp Pro Val Arg Lys Lys Ile Val Phe Val Thr Phe Leu Phe Phe 20 25 30 Tyr Leu Gly Thr Leu Leu Gly Asn Phe Leu Ile Ile Thr Thr Ile Lys 35 40 45 Thr Ser Gln Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe His Leu 50 55 60 Ser Leu Ser Asp Thr Cys Phe Cys Thr Ser Ile Ala Pro Arg Met Ile 65 70 75 80 Val Asp Ala Leu Leu Lys Arg Ala Thr Ile Ser Phe Arg Glu Cys Met 85 90 95 Ile Gln Val Phe Ser Phe His Phe Phe Gly Cys Leu Glu Ile Phe Ile 100 105 110 Leu Ile Leu Met Ala Ala Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu

Page 626

115 069269_0225_SL.TXT 120 125 His Tyr Thr Thr Ile Met Ser Arg Gln Val Cys Ala Val Leu Val Ala 130 135 140 Ile Ala Trp Val Gly Ser Cys Val His Ser Leu Ala Gln Ile Phe Leu 145 150 155 160 Ala Leu Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr His 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr His Val 180 185 190 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Thr Leu Ser 195 200 205 Phe Val Met Leu Met Cys Ser Tyr Val Val Ile Leu Tyr Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Met Ser 225 230 235 240 His Ile Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Leu Tyr 245 250 255 Thr Arg Pro Ala Thr Thr Phe Pro Met Asp Lys Met Ile Ala Val Phe 260 265 270 Tyr Thr Leu Gly Thr Pro Leu Ile Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Arg Lys Lys Leu 290 295 300 Ile Ser Asp Asp Lys Arg 305 310

<210> 565

Page 627

069269_0225_SL.TXT <211> 915 <212> DNA <213> Canis familiaris <400> 565

atggtgatga atagcactgt gaatgaattc attctgtttg gcttgacaca ggatccaaga 60 aaacagaaag caatatttgg ggtcttcttg atgctttatc ttgccacact gttgggaaac 120 tttctcattg tagtgactat taaaagaagc aggacccttg ggagtcccat gtacttcttc 180 ctattttacc tgtcctttgc tgatgcttgc ctctctacaa ccatttcccc cagattgatt 240 gtggatgcca tttctcagag gaagaccatt tcctacaagg agtgcatggc tcaggtcttt 300 acaggccact tctttggatg cacggaaatc ttcgtgctga tcgtcatggc ttttgatcgc 360 tatgtagcca tttgtaagcc cttgcgatac acaaccatca tgaacaggca tgtctgcagt 420 gtgctggtga ttctgggttg ggtgggatcc tgtatccact cttcagcaca aattgtcctg 480 gctttgagat tgcctttctg tggtcccaat gtgattgatc actatttctg tgacttgcag 540 cccttgttga aacttgcttg catggacact tatgtaataa atttgctagt tgtttctaac 600 agtggagcca tatgcacagt gagtttcata atcctgctta tctcctatgt tatcatcttg 660 tactctctga gaaactacag tgcagaagga aggcgaaaag ccctttcaac ctgcacctcc 720 cattttattg tggttgtcct attttttggc ccatgtatat tcatatatac acgtccggca 780 accacatttc cagtagacaa ggtggtggct gtgttttata ccactggggc acccttgctc 840 aaccctctga tctatacact gaggaatgca gaagtgaaaa atgccatgaa aaagttatgg 900 tgtaacaaag tgtga 915

<210> 566 <211> 304 <212> PRT <213> Canis familiaris <400> 566

Met Val Met Asn Ser Thr Val Asn Glu Phe Ile Leu Phe Gly Leu Thr 1 5 10 15

Gln Asp Pro Arg Lys Gln Lys Ala Ile Phe Gly Val Phe Leu Met Leu 20 25 30

Page 628

Tyr Leu Ala 35 Thr Leu Leu Gly 069269_0225_SL.TXT Asn Phe Leu Ile Val Val 40 45 Thr Ile Lys Arg Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Ala Asp Ala Cys Leu Ser Thr Thr Ile Ser Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Ile Ser Gln Arg Lys Thr Ile Ser Tyr Lys Glu Cys Met 85 90 95 Ala Gln Val Phe Thr Gly His Phe Phe Gly Cys Thr Glu Ile Phe Val 100 105 110 Leu Ile Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Asn Arg His Val Cys Ser Val Leu Val Ile 130 135 140 Leu Gly Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Val Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Val Val Ser Asn Ser Gly Ala Ile Cys Thr Val Ser 195 200 205 Phe Ile Ile Leu Leu Ile Ser Tyr Val Ile Ile Leu Tyr Ser Leu Arg 210 215 220 Asn Tyr Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240

Page 629

His Phe Ile Val Val 245 Val Leu 069269_0225_SL.TXT Phe Phe Gly Pro Cys Ile 250 Phe Ile 255 Tyr Thr Arg Pro Ala Thr Thr Phe Pro Val Asp Lys Val Val Ala Val Phe 260 265 270 Tyr Thr Thr Gly Ala Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Cys Asn Lys Val 290 295 300

<210> 567 <211> 927 <212> DNA <213> Canis familiaris <400> 567

atgggacatg aaaatatcac agaattcatt ctcttgggac tttttagtga taaagatgag 60 aagaccgcct gttttgtgct gttcgtactt tgctacattg caattctctc aggaaacttg 120 ctcattcttc tcacaatcag gggcagccgc ctccgtgaac agcccatgta ctttttcctg 180 agctacctat ctttcatgga tgtctgcttc acttccacag tggcccccaa actgatcata 240 gacctactgg cccagcagaa gaccatctcc tacaatggct gcatggccca gatgttttat 300 gcccattttt ttggtgccac tgagatcttc atcttggtgg ccatggccta tgaccgatat 360 gcagccatct gcagacccct tcactatatg gtcatcatga gcagacaggt gtgctatgtc 420 cttgtaatgg cctcaattct cggagcattt acccattcaa tcatgcaagt attgattgtt 480 attgaacttc ccttctgtgg ccccaatcag atagaccact atttctgtga tgttttcccc 540 ttgctgaagc tggcctgcat ggatactagc ttgttggtta ttgtgatcat tactaccaca 600 ggagtgctgt ccattttgac ctttgttgcc ttggtaattt cttacatcat catcctgtct 660 accctgagga cctactcatc ccagggctgc cgcaaagccc tctctacctg tggctcacac 720 atcactgttg tgttcatgtt cttcttgcct ctcatcttca catatgtccc catggcggat 780 tccgtcagta atgacaaagt gtttgcccta ttttatacca tgattgctcc catgttcaac 840 cctctcatct acacattgag aaacacagac atgaagaacg ccatgaggaa aatgtggtgc 900

Page 630

069269_0225_SL.TXT cgggatgcac ggtttgaagg gaaatga

927 <210> 568 <211> 308 <212> PRT <213> Canis familiaris <400> 568

Met 1 Gly His Glu Asn Ile Thr Glu Phe Ile Leu Leu Gly Leu Phe 15 Ser 5 10 Asp Lys Asp Glu Lys Thr Ala Cys Phe Val Leu Phe Val Leu Cys Tyr 20 25 30 Ile Ala Ile Leu Ser Gly Asn Leu Leu Ile Leu Leu Thr Ile Arg Gly 35 40 45 Ser Arg Leu Arg Glu Gln Pro Met Tyr Phe Phe Leu Ser Tyr Leu Ser 50 55 60 Phe Met Asp Val Cys Phe Thr Ser Thr Val Ala Pro Lys Leu Ile Ile 65 70 75 80 Asp Leu Leu Ala Gln Gln Lys Thr Ile Ser Tyr Asn Gly Cys Met Ala 85 90 95 Gln Met Phe Tyr Ala His Phe Phe Gly Ala Thr Glu Ile Phe Ile Leu 100 105 110 Val Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Arg Pro Leu His 115 120 125 Tyr Met Val Ile Met Ser Arg Gln Val Cys Tyr Val Leu Val Met Ala 130 135 140 Ser Ile Leu Gly Ala Phe Thr His Ser Ile Met Gln Val Leu Ile Val 145 150 155 160 Ile Glu Leu Pro Phe Cys Gly Pro Asn Gln Ile Asp His Tyr Phe Cys 165 170 175

Page 631

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Asp Val Phe Pro 180 Leu Leu Lys Leu Ala Cys Met Asp Thr Ser Leu Leu 185 190 Val Ile Val Ile Ile Thr Thr Thr Gly Val Leu Ser Ile Leu Thr Phe 195 200 205 Val Ala Leu Val Ile Ser Tyr Ile Ile Ile Leu Ser Thr Leu Arg Thr 210 215 220 Tyr Ser Ser Gln Gly Cys Arg Lys Ala Leu Ser Thr Cys Gly Ser His 225 230 235 240 Ile Thr Val Val Phe Met Phe Phe Leu Pro Leu Ile Phe Thr Tyr Val 245 250 255 Pro Met Ala Asp Ser Val Ser Asn Asp Lys Val Phe Ala Leu Phe Tyr 260 265 270 Thr Met Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg Asn 275 280 285 Thr Asp Met Lys Asn Ala Met Arg Lys Met Trp Cys Arg Asp Ala Arg 290 295 300 Phe Glu Gly Lys

305 <210> 569 <211> 933 <212> DNA <213> Canis familiaris <400> 569 atgcacctga ataataatgt gactgagttc attctgcttg gattgaccca ggatcctgtt agaaaaaaaa tagtgtttgt cacttttttg tttttctatt tggggacatt gctgggtaac tttctgatta ttactactat caagaccagc cagacactag ggagtccaat gtacttcttc cttttccacc tatccttgtc tgacacctgc ttctgtactt ccatagcccc tagaatgatt gttgatgcac ttttgaaaag ggccacaatc tctttcaggg agtgcatgat acaagtcttt Page 632

120

180

240

300

069269_0225_SL.TXT

tcattccact tctttggctg cctggagatc ttcatcctta tcctcatggc tgctgaccgc 360 tatgtggcca tctgtaagcc cctgcactac acaaccatca tgagtcgaca ggtctgtgct 420 gtgctggtgg ctattgcctg ggtggggtcc tgtgtgcatt ctttagctca gatttttctg 480 gccctgagtt tacctttctg tggtcccaat gtgatcgatc actatctttg tgacttgcag 540 cccttgttga aacttgcctg tgcagatacc tatgtgatca atctactgtt gatatccaat 600 agtggggcca tttgtacact gagttttgtc atgctgatgt gctcctatgt tgtcatcttg 660 tattctctga gaaatcacag tgctgaaggg aggaggaaag ccctctccac ctgcatctcc 720 cacatcattg tagtcgtctt gttctttggt ccttgcatat ttatatacac acgccctgca 780 accacctttc ccatggataa gatgatagct gtattttata cacttggaac acctttgatc 840 aatcctctga tttacacact taggaatgca gaagtgaaaa atgccatgaa gaagttatgg 900 aggaagaagt tgatttcaga tgacaaaaga tga 933

<210> 570 <211> 310 <212> PRT <213> Canis familiaris <400> 570

Met 1 His Leu Asn Asn 5 Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Gln Asp Pro Val Arg Lys Lys Ile Val Phe Val Thr Phe Leu Phe Phe 20 25 30 Tyr Leu Gly Thr Leu Leu Gly Asn Phe Leu Ile Ile Thr Thr Ile Lys 35 40 45 Thr Ser Gln Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe His Leu 50 55 60 Ser Leu Ser Asp Thr Cys Phe Cys Thr Ser Ile Ala Pro Arg Met Ile 65 70 75 80 Val Asp Ala Leu Leu Lys Arg Ala Thr Ile Ser Phe Arg Glu Cys Met 85 90 95

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Ile Gln Val Phe Ser Phe 100 His Phe Phe 105 Gly Cys Leu Glu Ile Phe Ile 110 Leu Ile Leu Met Ala Ala Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Ser Arg Gln Val Cys Ala Val Leu Val Ala 130 135 140 Ile Ala Trp Val Gly Ser Cys Val His Ser Leu Ala Gln Ile Phe Leu 145 150 155 160 Ala Leu Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Leu 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Leu Ile Ser Asn Ser Gly Ala Ile Cys Thr Leu Ser 195 200 205 Phe Val Met Leu Met Cys Ser Tyr Val Val Ile Leu Tyr Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ile Ser 225 230 235 240 His Ile Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Ala Thr Thr Phe Pro Met Asp Lys Met Ile Ala Val Phe 260 265 270 Tyr Thr Leu Gly Thr Pro Leu Ile Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Arg Lys Lys Leu 290 295 300

Page 634

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Ile Ser Asp Asp Lys Arg 305 310 <210> 571 <211> 927 <212> DNA <213> Canis familiaris <400> 571

atggagaatc caaaaaatgt gactgaattc attcttttgg gcattacaga gaacccagag 60 ctgcggaaaa tgctctctgc tgtgtttcta atcatgtatg tgtccacggt tttgggaaac 120 ctagtaattg tggtaactgt gatcacaagt cagagtctga gatcacctat gtattttttc 180 cttattttct tatccctttt ggatgttacc tactcttctg tcattgcccc caagatgatt 240 gtggactccc tctccaagag cactgtcatc tccttagaag gttgcatggc gcagctcttt 300 gcagagcatt tctttggtgg tgtggggatc atccttctca tcgtgatggc ctatgaccgc 360 tacgtggcca tctgtaagcc cctgcactac ttgaccatca tgagccctcg gatgtgctgc 420 ctgctgctgg gaggggcctg ggtgggggga tttatccatg cagcaataca gcttctcttc 480 atgtatcaaa tacccttctg tggccccaat gtcattgatc attttatatg cgatttgttt 540 cccttgttga aactggcctg catggacacc cacaccctgg gtctcctagt catcctcaac 600 agtggggtga tgtgtatgac catcttcctt attctcattg cctcctacgt ggtcatcctc 660 tgctctctga agtcttgcag ctctgaaggg cggcgcaaag ccttctccac ctgtggctcc 720 cacctcaccg tggttgtctt gttctttgtg ccatgcattt tcctgtacgt gcggcctgtg 780 gccacctacc ccattgacaa ggcaatggct gtgtctgatt ccatcatcac acccatgtta 840 aatcccttga tctacaccct gaggaattca gaggtgaaaa atgccatgag gaaactgggg 900 aaacaaagga gttttgttgg caagtga 927

<210> 572 <211> 308 <212> PRT <213> Canis familiaris <400> 572

Met Glu Asn Pro Lys Asn Val Thr Glu Phe Ile Leu Leu Gly Ile Thr Page 635

0 6926 9_02 25_S L.TX T 1 5 10 15 Glu Asn Pro Glu Leu Arg Lys Met Leu Ser Ala Val Phe Leu Ile Met 20 25 30 Tyr Val Ser Thr Val Leu Gly Asn Leu Val Ile Val Val Thr Val Ile 35 40 45 Thr Ser Gln Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Ile Phe Leu 50 55 60 Ser Leu Leu Asp Val Thr Tyr Ser Ser Val Ile Ala Pro Lys Met Ile 65 70 75 80 Val Asp Ser Leu Ser Lys Ser Thr Val Ile Ser Leu Glu Gly Cys Met 85 90 95 Ala Gln Leu Phe Ala Glu His Phe Phe Gly Gly Val Gly Ile Ile Leu 100 105 110 Leu Ile Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Cys Leu Leu Leu Gly 130 135 140 Gly Ala Trp Val Gly Gly Phe Ile His Ala Ala Ile Gln Leu Leu Phe 145 150 155 160 Met Tyr Gln Ile Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Ile 165 170 175 Cys Asp Leu Phe Pro Leu Leu Lys Leu Ala Cys Met Asp Thr His Thr 180 185 190 Leu Gly Leu Leu Val Ile Leu Asn Ser Gly Val Met Cys Met Thr Ile 195 200 205 Phe Leu Ile Leu Ile Ala Ser Tyr Val Val Ile Leu Cys Ser Leu Lys

Page 636

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210 215 220

Ser 225 Cys Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Gly Ser 230 235 240 His Leu Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Leu Tyr 245 250 255 Val Arg Pro Val Ala Thr Tyr Pro Ile Asp Lys Ala Met Ala Val Ser 260 265 270 Asp Ser Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Val Lys Asn Ala Met Arg Lys Leu Gly Lys Gln Arg Ser

290 295 300 Phe Val Gly Lys 305 <210> 573 <211> 933 <212> DNA <213> Canis familiaris

<400> 573

atggatatga taaaaacaaa cttcactgtg actgagtttg tgttcttggg gctgtcatct 60 cagccaaaga tgcagctcat tctttttatt atgttcttgt tcttctattt attaacagtt 120 gtggggaata ttataattat cactattatc cagatagaac ctcgtctcca aacccccatg 180 tacttcttcc ttactaattt atcctttctg gacatctgct acacatccac caatgtccca 240 caaatgctgt ccaacatgat gggaaaaaag accatcccct tctctagctg tgctactcag 300 atgtacttct ccctctcctt tggaatgatt gaatgtgttc tccttggggt catggcttat 360 gacagatatg tagccatttg tcatcctctc cattatactg tcattatgaa ccaaagcatc 420 tgtgtccaat tggcagccat ttcttggtcc agtagcttcc tgagttccat ggttatcaat 480 gtcctcacct tgagtttgcc ctactgtggg cccaatgtcc tgaatcactt tttttgtgag 540 gttccttctg tcttgaggtt agcttgcact gacacctcat ttacagagct ggttgtcttt 600

Page 637

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atcttcagta tcatcattgt cttcatccct tttctcctca ttgttgtttc ctatgcccga 660 atccttctat cagttctcag gatacggtca gcctccggga ggcacaaagc actatccact 720 tgtgcctccc atctgacagt ggtggcctta ttctatggaa ctgccatctt tatgtacatg 780 agaccccagt cgaagtcctc cagggctggg ggcaagatca ttgcagtgtt ctacactgtg 840 atcacaccca tgctcaaccc cttgatctat agcctaagga accaggatgt gaaaggcgct 900 ttaaggagag ctattgcaaa acggaggaca tga 933

<210> 574 <211> 310 <212> PRT <213> Canis familiaris <400> 574

Met Asp Met Ile Lys Thr Asn Phe Thr Val Thr Glu Phe Val Phe Leu 1 5 10 15 Gly Leu Ser Ser Gln Pro Lys Met Gln Leu Ile Leu Phe Ile Met Phe 20 25 30 Leu Phe Phe Tyr Leu Leu Thr Val Val Gly Asn Ile Ile Ile Ile Thr 35 40 45 Ile Ile Gln Ile Glu Pro Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu 50 55 60 Thr Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Thr Asn Val Pro 65 70 75 80 Gln Met Leu Ser Asn Met Met Gly Lys Lys Thr Ile Pro Phe Ser Ser 85 90 95 Cys Ala Thr Gln Met Tyr Phe Ser Leu Ser Phe Gly Met Ile Glu Cys 100 105 110 Val Leu Leu Gly Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125

Page 638

Pro Leu 130 His Tyr Thr Val Ile 135 069269_0225_SL.TXT Met Asn Gln Ser Ile Cys 140 Val Gln Leu Ala Ala Ile Ser Trp Ser Ser Ser Phe Leu Ser Ser Met Val Ile Asn 145 150 155 160 Val Leu Thr Leu Ser Leu Pro Tyr Cys Gly Pro Asn Val Leu Asn His 165 170 175 Phe Phe Cys Glu Val Pro Ser Val Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 Ser Phe Thr Glu Leu Val Val Phe Ile Phe Ser Ile Ile Ile Val Phe 195 200 205 Ile Pro Phe Leu Leu Ile Val Val Ser Tyr Ala Arg Ile Leu Leu Ser 210 215 220 Val Leu Arg Ile Arg Ser Ala Ser Gly Arg His Lys Ala Leu Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ala Leu Phe Tyr Gly Thr Ala Ile 245 250 255 Phe Met Tyr Met Arg Pro Gln Ser Lys Ser Ser Arg Ala Gly Gly Lys 260 265 270 Ile Ile Ala Val Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu

275 280 285

Ile Tyr Ser Leu Arg Asn Gln Asp Val Lys Gly Ala Leu Arg Arg Ala

290 295 300 Ile Ala Lys Arg Arg Thr 305 310

<210> 575 <211> 915 <212> DNA <213> Canis familiaris

Page 639

069269_0225_SL.TXT <400> 575

atggtgatga atagcactgt gaatgaattc attctgtttg gcttgacaca ggatccaaga 60 aaacagaaag cagtatttgg ggtcttcttg atgttttacc ttgccacact gttgggaaac 120 tttctcattg tagtgactat taaaagaagc aggacccttg ggagtcccat gtacttcttc 180 ctattttacc tgtcttttac tgatgcttgc ctctctacca ccattgcccc cagattgatt 240 gtggatgcca tttctcagag gaagaccatt tcctacaatg agtgcatgac tcaagtcttt 300 tcagcccact tctttggatg catggaaatc ttcgtgctga tcctgatggc ttttgatcgc 360 tatgtagcca tttgtaagcc cttgcgatac acaaccatca tgaacaggca tgtctgcagt 420 gtgctggtga ttctgggttg ggtgggatcc tgtatccact cttcagcaca aattttcctg 480 gcttcgagat tgcctttctg tggtcccaat gtgattgatc actatttctg tgacttgcag 540 cccttgttga aacttgcttg catggacact tatgtaataa atttgctagt tgtttctaac 600 agtggagcca tatgcacggt gagtttcata attctgctta tctcctatgt tatcatcttg 660 tactctctga gaaactacag tgcagaagga aggcgaaaag ccctttcgac ctgcacctcc 720 cattttattg tggttgtcct attttttggc ccatgtatat tcatatatac acgtccggca 780 accacatttc cagtagacaa ggtggtggct gtgttttata cctttgggac acccttgctg 840 aaccctctga tctatacact gaggaatgcg gaagtgaaaa atgccatgaa aaagttatgg 900 tgtagcaaag tgtga 915

<210> 576 <211> 304 <212> PRT <213> Canis familiaris <400> 576

Met 1 Val Met Asn Ser Thr Val Asn Glu Phe Ile Leu Phe Gly Leu Thr 5 10 15 Gln Asp Pro Arg Lys Gln Lys Ala Val Phe Gly Val Phe Leu Met Phe 20 25 30 Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45

Page 640

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Arg Ser 50 Arg Thr Leu Gly Ser Pro 55 Met Tyr Phe Phe Leu Phe Tyr 60 Leu Ser Phe Thr Asp Ala Cys Leu Ser Thr Thr Ile Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Ile Ser Gln Arg Lys Thr Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ser Ala His Phe Phe Gly Cys Met Glu Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Asn Arg His Val Cys Ser Val Leu Val Ile 130 135 140 Leu Gly Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Phe Leu 145 150 155 160 Ala Ser Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Val Val Ser Asn Ser Gly Ala Ile Cys Thr Val Ser 195 200 205 Phe Ile Ile Leu Leu Ile Ser Tyr Val Ile Ile Leu Tyr Ser Leu Arg 210 215 220 Asn Tyr Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Phe Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255

Page 641

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Thr Arg Pro Ala 260 Thr Thr Phe Pro Val Asp Lys Val Val Ala Val Phe 265 270 Tyr Thr Phe Gly Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Cys Ser Lys Val 290 295 300

<210> 577 <211> 915 <212> DNA <213> Canis familiaris <400> 577

atgtcaatga atagcagcgt gaatgaattc attctgcttg gcttgacaca ggatccaaga 60 aaacagaaag caatatttgg ggtcttctta atgctttacc ttgccacact gttgggaaac 120 tttctcattg tagtgactat taaaagaagc aggactcttg ggagtcccat gtacttcttc 180 ctattttacc tgtcctttgc tgatgcctgc ttctctacaa ccattgcccc cagattgatt 240 gtggatgcca tttcccagca gaagaccatt tcctacaatg agtgcatgac tcaggtcttt 300 tcagcccact tctttgcttg catggaaatc ttcgtgctga tcctcatggc ttttgatcgc 360 tatgtagcca tttgtaagcc cttgcgatac acaaccatca tgaacaggca tgtctgcagt 420 gtgctggtga ttctgggttg ggtgggatcc tgtatccact cttcagcaca aattttcctg 480 gcttcgagat tgcctttctg tggtcccaat gtgattgatc actatttctg tgatttacag 540 cccttgttga aacttgcttg catggatact tatgtaataa atttgctagt tgttactaat 600 agtggagcca tatgcttggt gagtttcata atcttgctta tctcctatgt tgtcatcttg 660 tactctctga gaaaccacag tgcagaagga aggcgaaaag ccctttcaac ctgcacctcc 720 cattttattg tggttgtcct attttttggc ccatgtatat tcatgcatac acgcccggca 780 accacatttc cagtagacaa ggtggtggca gtgttttata ccattgggac acccttgctg 840 aaccctctga tctatacact gaggaatgcg gaagtgaaaa atgccatgaa aaagttatgg 900 tgtagcaaag ggtga 915

Page 642

069269_0225_SL.TXT <210> 578 <211> 304 <212> PRT <213> Canis familiaris <400> 578

Met Ser Met Asn Ser Ser Val Asn Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Gln Asp Pro Arg Lys Gln Lys Ala Ile Phe Gly Val Phe Leu Met Leu 20 25 30 Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45 Arg Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Ala Asp Ala Cys Phe Ser Thr Thr Ile Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Ile Ser Gln Gln Lys Thr Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ser Ala His Phe Phe Ala Cys Met Glu Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Asn Arg His Val Cys Ser Val Leu Val Ile 130 135 140 Leu Gly Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Phe Leu 145 150 155 160 Ala Ser Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190

Page 643

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Ile Asn Leu Leu Val Val Thr Asn Ser Gly Ala Ile Cys Leu Val Ser 195 200 205 Phe Ile Ile Leu Leu Ile Ser Tyr Val Val Ile Leu Tyr Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Phe Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Met His 245 250 255 Thr Arg Pro Ala Thr Thr Phe Pro Val Asp Lys Val Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Cys Ser Lys Gly 290 295 300

<210> 579 <211> 915 <212> DNA <213> Canis familiaris <400> 579

atgtcaatga acagcagtgt gaatgaattc attttgcttg gcttgacaca ggatccaaga 60 aaacagaaag caatatttgg ggtcttcttg atgttttacc ttgccacact gttgggaaac 120 tttctcattg tagtgactat taaaagaagc aggacccttg ggagtcccat gtacttcttc 180 ctattttacc tgtcctttgc tgatgcctgc ttttctacaa ccattgcccc caggttgatt 240 gtggatgcca tttcccagca gaagactatt tcctacaatg agtgcatgac tcaggtcttt 300 gcagtccact tctttgcttg catgggaatc ttcgtgctga tcctcatggc ttttgatcgc 360 tatgtagcta tttgtaagcc cttgcgatac acaaccatca tgaacaggca tgtctgcagt 420 gtgctggtga ctctgggttg ggtgggatcc tgtatccact cttcagcaca aattgtcctg 480

Page 644

069269_0225_SL.TXT

gctttgaaat tgcctttctg tggtcccaat atgattgatc actatttctg tgacttgcag 540 cccttgttga aacttgcttg catggacact tatgtaataa atttgctagt tgttactaac 600 agtggagcca tatgcatggt gagtttcata atcttgctta tctcctatgt tatcatcttg 660 tactctctga gaaactacag tgcagaagga aggcgaaaag ccctttcaac ctgcacttcc 720 cattttattg tggttgtctt atgttttggc ccatgtatat tcatttatac acgtccagca 780 accacatttc cagtagacaa ggtggtggca gtgttttata ccattgggac acccttgctg 840 aaccctctga tctacacact gaggaatgca gaagtgaaaa ttgcaatgaa aatgttatgg 900 tgtagcaaag tatga 915

<210> 580 <211> 304 <212> PRT <213> Canis familiaris <400> 580

Met Ser Met Asn Ser Ser Val Asn Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Gln Asp Pro Arg Lys Gln Lys Ala Ile Phe Gly Val Phe Leu Met Phe 20 25 30 Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45 Arg Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Ala Asp Ala Cys Phe Ser Thr Thr Ile Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Ile Ser Gln Gln Lys Thr Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Val His Phe Phe Ala Cys Met Gly Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu

Page 645

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115 120 125 Arg Tyr Thr Thr Ile Met Asn Arg His Val Cys Ser Val Leu Val Thr 130 135 140 Leu Gly Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Val Leu 145 150 155 160 Ala Leu Lys Leu Pro Phe Cys Gly Pro Asn Met Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Val Val Thr Asn Ser Gly Ala Ile Cys Met Val Ser 195 200 205 Phe Ile Ile Leu Leu Ile Ser Tyr Val Ile Ile Leu Tyr Ser Leu Arg 210 215 220 Asn Tyr Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Phe Ile Val Val Val Leu Cys Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Ala Thr Thr Phe Pro Val Asp Lys Val Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Ile Ala Met Lys Met Leu Trp Cys Ser Lys Val 290 295 300

<210> 581 <211> 915 <212> DNA <213> Canis familiaris

Page 646

069269_0225_SL.TXT <400> 581

atggcgatga acagcagtgt gaatgaattc attctgtttg gcttgacaca ggatccaaga 60 aaacagaaag caatatttgg ggtcttcttg atgttttacc ttgccacact gttgggaaac 120 tttctcattg tagtgactat taaaagaagc aggacccttg ggagtcccat gtacttcttc 180 ctattttacc tgtcctttgc tgatgcctgc ttctctacaa ccacagctcc caggttgatt 240 gtggatgcca tttcccagca gaagactatt tcctacaatg agtgcatgac tcaggtcttt 300 tcagcccatt tctttggatg catggaaatc ttcgtgctga tcctgatggc ttttgatcgc 360 tatgtagcca tttgtaagcc cttgcgttac acaaccatcc tgaacaggca tgtctgcagt 420 gtactggtga ttctgggttg ggtgggatcc tgtatccact cttcggcaca aattgtcctg 480 gctttgagat tgcctttctg tggtcccaat gtgattgatc actatttctg tgacttgcag 540 cccttgctga aacttgcttg catggacact tatgtaataa atttgctagt tgtttctaac 600 agtggagcca tatgcacggt gagtttcata atcctgctta tctcctatgt tatcatcttg 660 tactctctga gaaactacag tgcagaagga aagcgaaaag ccctttcgac ctgcacctcc 720 cattttattg tggttgtcct attttttggt ccatgtatat tcatgtatac acgcccagca 780 accacatttc cagtagacaa ggtggtggca gtgttttata ccattggggc acccttgctg 840 aaccctctga tctatacact gaggaatgcg gaagtgaaaa atgccatgaa aaagttatgg 900 tgtagcaaat tgtga 915

<210> 582 <211> 304 <212> PRT <213> Canis familiaris <400> 582

Met 1 Ala Met Asn Ser Ser Val Asn Glu Phe Ile Leu Phe Gly Leu Thr 5 10 15 Gln Asp Pro Arg Lys Gln Lys Ala Ile Phe Gly Val Phe Leu Met Phe 20 25 30 Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45

Page 647

Arg Ser 50 Arg Thr Leu Gly Ser 55 069269_0225_SL.TXT Pro Met Tyr Phe Phe Leu 60 Phe Tyr Leu Ser Phe Ala Asp Ala Cys Phe Ser Thr Thr Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Ile Ser Gln Gln Lys Thr Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ser Ala His Phe Phe Gly Cys Met Glu Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Leu Asn Arg His Val Cys Ser Val Leu Val Ile 130 135 140 Leu Gly Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Val Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Val Val Ser Asn Ser Gly Ala Ile Cys Thr Val Ser 195 200 205 Phe Ile Ile Leu Leu Ile Ser Tyr Val Ile Ile Leu Tyr Ser Leu Arg 210 215 220 Asn Tyr Ser Ala Glu Gly Lys Arg Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Phe Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Met Tyr 245 250 255

Page 648

Thr Arg Pro Ala Thr Thr Phe 069269_0225_SL.TXT Pro Val Asp Lys Val Val Ala Val Phe 260 265 270

Tyr Thr Ile Gly Ala Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285

Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Cys Ser Lys Leu 290 295 300

<210> 583 <211> 915 <212> DNA <213> Canis familiaris <400> 583

atggcgatga acagcagtgt gaatgaattc attctgtttg gcttgacaca ggatccaaga 60 aaacagaaag caatatttgg ggtcttcttg atgttttacc ttgccacact gttgggaaac 120 tttctcattg tagtgactat taaaagaagc aggacccttg ggagtcccat gtacttcttc 180 ctattttacc tgtcctttgc tgatgcctgc ttctctacaa ccacagctcc caggttgatt 240 gtagatgcca tttctcagca gaagaccatt tcctacaacg agtgcatgac tcaggtgttt 300 tcagcccatt tctttggatg catggaaatc ttcgtgctga tactgatggc tttggatcgc 360 tatgtagcca tttgtaagcc cttgcgatac acaaccatca tgaacaggca tgtctgcagt 420 gtgctggtga ttctgggttg ggtgggatcc tgtatccact cttcggcaca aattgtcctg 480 gctttgagat tgcctttctg tggtcccaac gtgattgatc actatttctg tgacttgcag 540 cccttgttga aacttgcttg catggacact tatgtaataa atttgctagt tgttactaac 600 agtggagcca tatgcatggt gagtttcata attctgctta tctcctatgt tatcatcttg 660 tactctctga gaaactacag tgcagaagga aggcgaaaag ccctttcgac ctgcacctcc 720 cattttattg tggttgtcct attttttggc ccatgtatat tcatatatac acgcccagca 780 accacatttc cagtagacaa ggtggtggct gtgttttata ccattgggac acccttgctc 840 aaccctctga tctacacact gagaaatgcg gaagtgaaaa ttgccatgaa aatgttatgg 900 tgtagcaaag tatga 915

<210> 584

Page 649

069269_0225_SL.TXT <211> 304 <212> PRT <213> Canis familiaris <400> 584

Met Ala Met Asn Ser Ser Val Asn Glu Phe Ile Leu Phe Gly Leu Thr 1 5 10 15 Gln Asp Pro Arg Lys Gln Lys Ala Ile Phe Gly Val Phe Leu Met Phe 20 25 30 Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45 Arg Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Ala Asp Ala Cys Phe Ser Thr Thr Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Ile Ser Gln Gln Lys Thr Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ser Ala His Phe Phe Gly Cys Met Glu Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Asn Arg His Val Cys Ser Val Leu Val Ile 130 135 140 Leu Gly Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Val Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190

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Ile Asn Leu Leu Val Val 195 Thr Asn Ser Gly Ala Ile Cys Met Val Ser 200 205 Phe Ile Ile Leu Leu Ile Ser Tyr Val Ile Ile Leu Tyr Ser Leu Arg 210 215 220 Asn Tyr Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Phe Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Ala Thr Thr Phe Pro Val Asp Lys Val Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Ile Ala Met Lys Met Leu Trp Cys Ser Lys Val 290 295 300

<210> 585 <211> 912 <212> DNA <213> Canis familiaris <400> 585 atgtcagtga atagcagtgt gaatgaattc attctgcttg gcttgacaca ggatccaaga 60 aaacagaaag caatatttgg ggtcttcttg atgttttacc ttgccacact gttgggaaac 120 tttctcattg tagtgactat taaaagaagc aggacccttg ggagtcccat gtacttcttc 180 ctattttacc tgtcctttgc tgatgcctgc ttttctacaa ccacagctcc caggttgatt 240 gtggatgcca tttcccagca gaagactatt tcctacaatg agtgcatgac tcaggtcttt 300 gcatcccatt tctttggttg catgggaatc tttgtgctga tcctcatggc ttttgatcgc 360 tatgtagcta tttgtaagcc cttgcgatac acaaccatca tgaacaggca tgtctgcagt 420 gtgctggtga ttctgggttg ggtgggatcc tgtatccact cttcagcaca aattgtcctg 480 gctttgagat tgcctttctg tggtcccaat atgattgatc actatttctg tgacttgcag 540

Page 651

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cccttgttga aacttgcttg catggacact tatgtaataa atttgctagt tgttactaac 600 agtggagcca tatgcatggt gagtttcata attctgctta tctcttatat tatcatcttg 660 tactctctga gaaaccacag tgcagaagga aggcgaaaag ccctttcgac ctgcacctcc 720 cattttattg tggttgtctt atgttttgtc ccatgcatat tcatatatac acgtccggca 780 accacatttc cagtagacaa ggtggtggct gtgttttata ccattgggac acccttgctc 840 aatcctctga tctacacact gaggaatgca gaagtgaaaa ttgccatgaa aaagttatgg 900 tgtagcaaag ta 912

<210> 586 <211> 304 <212> PRT <213> Canis familiaris <400> 586

Met Ser Val Asn Ser Ser Val Asn Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Gln Asp Pro Arg Lys Gln Lys Ala Ile Phe Gly Val Phe Leu Met Phe 20 25 30 Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45 Arg Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Ala Asp Ala Cys Phe Ser Thr Thr Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Ile Ser Gln Gln Lys Thr Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Ser His Phe Phe Gly Cys Met Gly Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125

Page 652

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Arg Tyr Thr 130 Thr Ile Met Asn Arg His Val Cys Ser Val Leu Val Ile 135 140 Leu Gly Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Val Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Met Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Val Val Thr Asn Ser Gly Ala Ile Cys Met Val Ser 195 200 205 Phe Ile Ile Leu Leu Ile Ser Tyr Ile Ile Ile Leu Tyr Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Phe Ile Val Val Val Leu Cys Phe Val Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Ala Thr Thr Phe Pro Val Asp Lys Val Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Ile Ala Met Lys Lys Leu Trp Cys Ser Lys Val 290 295 300

<210> 587 <211> 915 <212> DNA <213> Canis familiaris <400> 587

Page 653

069269_0225_SL.TXT

atggcaatga acagcagtgt gaatgaattc attctgtttg gcttgacaca ggatccaaga 60 aaacagaaag caatatttgg ggtcttcttg atgttttacc ttgccacact gttgggaaac 120 tttctcattg tagtgactat taaaagaagc aggacccttg ggagtcccat gtacttcttc 180 ctattttacc tgtcctttgc tgatgcctgc ttttctacaa ccacagctcc caggttgatt 240 gtggatgccc tttctcagca gaagaccatt tcctacaatg agtgcatgac tcaggtcttt 300 gcagtccact tctttggatg catggaaatc ttcgtgctga tcctgatggc ttttgatcgc 360 tatgtagcta tttgtaagcc cttgcgttac acaaccatca tgaacaggca tgtctgcagt 420 gtgctggtga ttctgggttg ggtgggatcc tgtatccact cttcagcaca aattgtcctg 480 gctttgagat tgcctttctg tggtcccaac gtgattgatc actatttctg tgacttgcag 540 cccttgctga aacttgcttg catggacact tatgtaataa atttgctagt tgtttctaac 600 agtggagcca tatgcacggt gagtttcaca atcttgctta tctcctatgt tatcatcttg 660 tactctctga gaaaccacag tgcagaagga aggcgaaaag ccctttcgac ctgcacctcc 720 cattttattg tggttgtcct attttttggc ccatgtatat tcatatatac acgcccagca 780 accacatttc cagtagacaa ggtggtggct gtgttttata ccattgggac acccttgctg 840 aaccctctga tctatacact gagaaataca gaagtgaaaa ttgccatgaa aaagttatgg 900 tgtagcaaag tatga 915

<210> 588 <211> 304 <212> PRT <213> Canis familiaris <400> 588

Met 1 Ala Met Asn Ser Ser Val Asn Glu Phe Ile Leu Phe Gly Leu Thr 5 10 15 Gln Asp Pro Arg Lys Gln Lys Ala Ile Phe Gly Val Phe Leu Met Phe 20 25 30 Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45 Arg Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu

Page 654

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50 55 60

Ser 65 Phe Ala Asp Ala Cys Phe Ser Thr Thr Thr Ala Pro Arg Leu Ile 70 75 80 Val Asp Ala Leu Ser Gln Gln Lys Thr Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Val His Phe Phe Gly Cys Met Glu Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Asn Arg His Val Cys Ser Val Leu Val Ile 130 135 140 Leu Gly Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Val Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Val Val Ser Asn Ser Gly Ala Ile Cys Thr Val Ser 195 200 205 Phe Thr Ile Leu Leu Ile Ser Tyr Val Ile Ile Leu Tyr Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Phe Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Ala Thr Thr Phe Pro Val Asp Lys Val Val Ala Val Phe

Page 655

260

069269_0225_SL.TXT 265 270

Tyr Thr Ile Gly Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Thr Glu Val Lys Ile Ala Met Lys Lys Leu Trp Cys Ser Lys Val

290 295 300 <210> 589 <211> 915 <212> DNA <213> Canis familiaris <400> 589

atggagttga atagcagtgt gaatgagttc attctgtttg ggttaacaca ggatgtttta 60 aaggagaaag tcgtacttgt ggtctttgtg tttctatacc ttgcaactct gttggcaaat 120 ttactgattg ttataaccat aagatacagc cagacacttg ggagccccat gtacttcttc 180 cttttctact tatcctttgc tgatgcctgc ttctcaacaa ccactgctcc taggttgata 240 gtagattctg tatctaagaa gaaagttatc tcctacaatg agtgcatgac tcagattttt 300 gcatttcact tctttgggtg catggagatc ttggtgcttg tcctcatgtc cttggatcgc 360 tatgtggcca tttgtaagcc tctgaggtat acaactatca tgagccggcg tgtctgtggt 420 acactggtga atctagcctg ggtggtgtct tgtatccatt cttctgcaca gattttcctg 480 gctttgaagt taccattctg tggacctaat gttattgatc attatttctg tgatatgcca 540 cctttgttga agcttgcatg catggacact catgcaacca atttactcat agtttttaat 600 agcggggcta tctgcacagt aagtttcatg gtcctgctta cctcttatat tttcatctta 660 cattctttga ataaccagag tgcagaagga agaaagaaag ccctctctac ctgcacatcc 720 cacattattg ttgtcatctt attttttgtt ccgtgtatat tcacatatac tcgccctgta 780 acttcatttc cagcggacaa gatggtggct gtgttttaca ctattgtgac acccttgctc 840 aatcctctaa tttacacgct gagaaatgca gaagtgaaaa atgccatgag gaagctatgg 900 tgcaacaaac tctga 915

<210> 590 <211> 304

Page 656

069269_0225_SL.TXT <212> PRT <213> Canis familiaris <400> 590

Met Glu Leu Asn Ser Ser Val Asn Glu Phe Ile Leu Phe Gly Leu Thr 1 5 10 15 Gln Asp Val Leu Lys Glu Lys Val Val Leu Val Val Phe Val Phe Leu 20 25 30 Tyr Leu Ala Thr Leu Leu Ala Asn Leu Leu Ile Val Ile Thr Ile Arg 35 40 45 Tyr Ser Gln Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Ala Asp Ala Cys Phe Ser Thr Thr Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ser Val Ser Lys Lys Lys Val Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Ile Phe Ala Phe His Phe Phe Gly Cys Met Glu Ile Leu Val 100 105 110 Leu Val Leu Met Ser Leu Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Ser Arg Arg Val Cys Gly Thr Leu Val Asn 130 135 140 Leu Ala Trp Val Val Ser Cys Ile His Ser Ser Ala Gln Ile Phe Leu 145 150 155 160 Ala Leu Lys Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Met Pro Pro Leu Leu Lys Leu Ala Cys Met Asp Thr His Ala 180 185 190

Page 657

Thr Asn Leu 195 Leu Ile Val Phe 069269_0225_SL.TXT Asn Ser Gly Ala Ile Cys 200 205 Thr Val Ser Phe Met Val Leu Leu Thr Ser Tyr Ile Phe Ile Leu His Ser Leu Asn 210 215 220 Asn Gln Ser Ala Glu Gly Arg Lys Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Ile Ile Val Val Ile Leu Phe Phe Val Pro Cys Ile Phe Thr Tyr 245 250 255 Thr Arg Pro Val Thr Ser Phe Pro Ala Asp Lys Met Val Ala Val Phe 260 265 270 Tyr Thr Ile Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp Cys Asn Lys Leu 290 295 300

<210> 591 <211> 936 <212> DNA <213> Canis familiaris <400> 591

atgcaaaacc aaagctttgt aactgagttt gttctcctgg ggctttcaca gaatcctaat 60 gttcagaaaa tagtatttgt tgtgtttttg tttggctaca ttgcaactgt tgggggcaac 120 ttgctaattg tggtgaccat cagcagcagc ccagcactct tggggtctcc catgtacttc 180 ttcttggctt ttctgtcctt cctggatgct tgcttctcca ctgtcattgc ccccaagatg 240 attgtggact ccctttatga gaggaaaaca atctcttttg gaggttgtat gactcaactc 300 tttgctgagc acttctttgc tggggttgaa gtgattgtcc tcacagccat ggcctatgac 360 cgctatgtgg ccatctgtaa acccttacac tacacaacta tcatgaactg gaggctctgt 420 agcattctga tgggcatagc ctggatgggg ggttttctgc attccatgat acaaattctc 480 tttactttcc agctgccttt ctgtggcccc aatgtcattg atcacttcat gtgtgatttg 540

Page 658

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tacccattac tggagcttgc ctgcactgac actcacatct ttggcctttt agtggtcgcc 600 aacagtgggt ctatctgcat cataatcttc tctttgttgc ttgtctcata tgttgtcatc 660 ttgctctctc tgagaaccca cagtcctgag gggcagcgga aagctctctc cacctgcgga 720 tctcacattg ctattgtggt tttgttcttt gtcccttgca tatttgtgta tgcacgacct 780 ccatctgctt tctcctttga caaaatggtg gctatatttt ataccattct aactccttta 840 ctcaatcctt tgatttacac tttcaggaat aaggaaatga aaaatgccat aaagaaagtg 900 tggagcagag taatgatggt ttgtagtgac aaataa 936

<210> 592 <211> 311 <212> PRT <213> Canis familiaris <400> 592

Met Gln Asn Gln Ser Phe Val Thr Glu Phe Val Leu Leu Gly Leu Ser 1 5 10 15 Gln Asn Pro Asn Val Gln Lys Ile Val Phe Val Val Phe Leu Phe Gly 20 25 30 Tyr Ile Ala Thr Val Gly Gly Asn Leu Leu Ile Val Val Thr Ile Ser 35 40 45 Ser Ser Pro Ala Leu Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Phe 50 55 60 Leu Ser Phe Leu Asp Ala Cys Phe Ser Thr Val Ile Ala Pro Lys Met 65 70 75 80 Ile Val Asp Ser Leu Tyr Glu Arg Lys Thr Ile Ser Phe Gly Gly Cys 85 90 95 Met Thr Gln Leu Phe Ala Glu His Phe Phe Ala Gly Val Glu Val Ile 100 105 110 Val Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro 115 120 125

Page 659

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Leu His 130 Tyr Thr Thr Ile Met Asn Trp Arg Leu Cys Ser Ile Leu Met 135 140 Gly Ile Ala Trp Met Gly Gly Phe Leu His Ser Met Ile Gln Ile Leu 145 150 155 160 Phe Thr Phe Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe 165 170 175 Met Cys Asp Leu Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr His 180 185 190 Ile Phe Gly Leu Leu Val Val Ala Asn Ser Gly Ser Ile Cys Ile Ile 195 200 205 Ile Phe Ser Leu Leu Leu Val Ser Tyr Val Val Ile Leu Leu Ser Leu 210 215 220 Arg Thr His Ser Pro Glu Gly Gln Arg Lys Ala Leu Ser Thr Cys Gly 225 230 235 240 Ser His Ile Ala Ile Val Val Leu Phe Phe Val Pro Cys Ile Phe Val 245 250 255 Tyr Ala Arg Pro Pro Ser Ala Phe Ser Phe Asp Lys Met Val Ala Ile 260 265 270 Phe Tyr Thr Ile Leu Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Phe 275 280 285 Arg Asn Lys Glu Met Lys Asn Ala Ile Lys Lys Val Trp Ser Arg Val 290 295 300 Met Met Val Cys Ser Asp Lys

305 310 <210> 593 <211> 945 <212> DNA

Page 660

069269_0225_SL.TXT <213> Canis familiaris <400> 593

atggagaatc caagaaatgt gactgaattc attcttttgg gcattacaga gaacccagag 60 ctgcggaaaa tgctctctgc tgtgtttcta atcatgtatg tgtccacggt tttgggaaac 120 ctagtaattg tggtaactgt gatcacaagt cagagtctga gatcacctat gtattttttc 180 cttcctttct tatccctttt ggatgttacc tactcttctg tcattgctcc caagatgatt 240 gtggactccc tctccaagag cactgccatc tccttagaag gttgcatgac ccagctcttt 300 gcagagcatt tctttggtgg tgtggggatc atccttctca tcgtgatggc ctatgaccgc 360 tatgtggcca tctgtaagcc cctgcactac atgaccatca tgagccctcg gatgtgctgc 420 ctgctgctgg gaggggcctg ggtggggggg tttatccatg cagcaataca gcttctcttc 480 atgtatcaac tacccttctg tggcctcaat gttattgatc actttatgtg tgatttgttt 540 cccttgttga aactggcctg catggacacc cacaccctgg gtatcctagt catcctcaac 600 agtggggtga tgtgtatgac catcttcctt atcctcatca cctcctacat ggtcatcctc 660 tgctctctga agtcttgcag ctctgaaggg cggcgcaaag ccttctccac ctgtggctcc 720 cacctcaccg tggttgtctt gttctttgtg ccatgcattt tcctatatgt gcggcctgtg 780 gccacgtacc ccattgacaa ggcaatggct gtgtctttta ccattgttac acccatgtta 840 aatcccttga tctacaccct gaggaattca gaggtgaaaa atgccgtgag gaaactggtg 900 aaacaaggga tcctgggcat cactagctca catgctaagg actaa 945

<210> 594 <211> 314 <212> PRT <213> Canis familiaris <400> 594

Met 1 Glu Asn Pro Arg Asn Val Thr Glu Phe Ile Leu Leu Gly Ile Thr 5 10 15 Glu Asn Pro Glu Leu Arg Lys Met Leu Ser Ala Val Phe Leu Ile Met 20 25 30 Tyr Val Ser Thr Val Leu Gly Asn Leu Val Ile Val Val Thr Val Ile 35 40 45

Page 661

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Thr Ser 50 Gln Ser Leu Arg Ser Pro 55 Met Tyr Phe Phe Leu Pro Phe 60 Leu Ser Leu Leu Asp Val Thr Tyr Ser Ser Val Ile Ala Pro Lys Met Ile 65 70 75 80 Val Asp Ser Leu Ser Lys Ser Thr Ala Ile Ser Leu Glu Gly Cys Met 85 90 95 Thr Gln Leu Phe Ala Glu His Phe Phe Gly Gly Val Gly Ile Ile Leu 100 105 110 Leu Ile Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Ser Pro Arg Met Cys Cys Leu Leu Leu Gly 130 135 140 Gly Ala Trp Val Gly Gly Phe Ile His Ala Ala Ile Gln Leu Leu Phe 145 150 155 160 Met Tyr Gln Leu Pro Phe Cys Gly Leu Asn Val Ile Asp His Phe Met 165 170 175 Cys Asp Leu Phe Pro Leu Leu Lys Leu Ala Cys Met Asp Thr His Thr 180 185 190 Leu Gly Ile Leu Val Ile Leu Asn Ser Gly Val Met Cys Met Thr Ile 195 200 205 Phe Leu Ile Leu Ile Thr Ser Tyr Met Val Ile Leu Cys Ser Leu Lys 210 215 220 Ser Cys Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Gly Ser 225 230 235 240 His Leu Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Leu Tyr 245 250 255

Page 662

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Val Arg Pro Val Ala Thr Tyr Pro Ile Asp Lys Ala Met Ala Val Ser 260 265 270 Phe Thr Ile Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Val Lys Asn Ala Val Arg Lys Leu Val Lys Gln Gly Ile 290 295 300 Leu Gly Ile Thr Ser Ser His Ala Lys Asp

305 310 <210> 595 <211> 918 <212> DNA <213> Canis familiaris <400> 595

atggaaagaa gcaacaatac agtgactgag ttcatcctgg tgggcttcac gacagaccca 60 gtgatgcagc tggtcctgtt tgtggtattc cttggtgtgt actctctgac tgtggtagca 120 aatgccaccc tcatagtgtt gatctgtaat gactcccggc tgcacacacc catgtatttt 180 ttcattggga atctatcttt tctggatctc tggtattcct ctgtctatac cccaaagatt 240 ctcttgacct gcatctctga agacaaaagc atctcctttg ctggctgtgt atgtcagttc 300 ttcttctctg ctggactggc atacagtgag tgttacctgt tggctgccat ggcttatgac 360 cgctatatgg ccatctcaaa gccactgcgc tatgctcagg ccatgtctat aaagctgtgt 420 gcatttttgg tagcatcctc atatcttggt ggttttatta actcttctat catcaccaaa 480 agaacttttg acctgaactt ctgtagtggc aatatcattg atgacttttt ttgtgatttg 540 tatcccctgg tgaagttggc ttgtggcagg aaagatggct accagactgt gctgtatttg 600 atcctgtgct ccaatgtcat cacccccaca gtgctcatcc tagcctccta ccagtttatt 660 attgccacca tcttgaggat ccgctccacc cagggccgcc tcaaagcctt ctctacgtgt 720 tcctcacacc tggtctctgt caccttgtac tatggctcca ttctctacat ctactctcgt 780 ccccgatcta gctattcttt ggacacagac aaaatagttt ctacatttta tactgtggtg 840

Page 663

900

918

069269_0225_SL.TXT ttccccatgt tgaatcccat gatctatagc ctgaggaata aggatgtgaa agaggctctg aataaactca ttaaataa <210> 596 <211> 305 <212> PRT <213> Canis familiaris <400> 596

Met Glu Arg Ser Asn Asn Thr Val Thr Glu Phe Ile Leu Val Gly Phe 1 5 10 15 Thr Thr Asp Pro Val Met Gln Leu Val Leu Phe Val Val Phe Leu Gly 20 25 30 Val Tyr Ser Leu Thr Val Val Ala Asn Ala Thr Leu Ile Val Leu Ile 35 40 45 Cys Asn Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Ile Gly Asn 50 55 60 Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val Tyr Thr Pro Lys Ile 65 70 75 80 Leu Leu Thr Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys 85 90 95 Val Cys Gln Phe Phe Phe Ser Ala Gly Leu Ala Tyr Ser Glu Cys Tyr 100 105 110 Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Met Ala Ile Ser Lys Pro 115 120 125 Leu Arg Tyr Ala Gln Ala Met Ser Ile Lys Leu Cys Ala Phe Leu Val 130 135 140 Ala Ser Ser Tyr Leu Gly Gly Phe Ile Asn Ser Ser Ile Ile Thr Lys 145 150 155 160 Arg Thr Phe Asp Leu Asn Phe Cys Ser Gly Asn Ile Ile Asp Asp Phe

Page 664

069269_0225_SL.TXT 165 170

Phe Cys Asp Leu Tyr Pro Leu Val Lys Leu Ala Cys Gly Arg 180 185 190 Gly Tyr Gln Thr Val Leu Tyr Leu Ile Leu Cys Ser Asn Val 195 200 205 Pro Thr Val Leu Ile Leu Ala Ser Tyr Gln Phe Ile Ile Ala 210 215 220 Leu Arg Ile Arg Ser Thr Gln Gly Arg Leu Lys Ala Phe Ser 225 230 235 Ser Ser His Leu Val Ser Val Thr Leu Tyr Tyr Gly Ser Ile 245 250 Ile Tyr Ser Arg Pro Arg Ser Ser Tyr Ser Leu Asp Thr Asp 260 265 270 Val Ser Thr Phe Tyr Thr Val Val Phe Pro Met Leu Asn Pro 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Asn Lys 290 295 300

175

Lys Asp

Ile Thr

Thr Ile

Thr Cys 240

Leu Tyr 255

Lys Ile

Met Ile

Leu Ile

Lys

305 <210> 597 <211> 924 <212> DNA <213> Canis familiaris <400> 597 atggatcact tcacacctcc caacaatgtg actgaattta ttctcttggg aatccacact tgcagaaaat attctttgtg gtcttcttgt tcatttttct ctggccaatc tgctcattgt cctaaccatc tccctcagct ccacactttc tatttctttc tcacttactt gtcctttata gatgcctcct acacctctgt Page 665 actcactcag atttactgtg agctcccatg gaccaccccc

120

180

240

069269_0225_SL.TXT aaaatgatca tcgacctgct gtaccagagg agaaccatct ccttgggtgg ctgcttgact cagctcttcg tggagcactt tctgggagga tccgagatca tcctcctcat tgtcatggcc tatgatcgct atgtggccat ctgcaagccc cttcactaca tgaccatcat gcgacacgga ctctgtcagc ttctagtggt agtggcctgg atagggggga tcctgcatgc cactgttcag atccttttca tggtcaacct acccttctgt ggccccaatg tcatcgacca ctttatgtgt gatctctttc ccctgctgaa acttgcctgc agcgacacct acaggttggg aatggtggta gcggccaaca gtggcgccat gtgcttgctc attttttcca tgctgctcat ctcctacaca gtcatcctga gttccttgag ctcccatggc tccgaaggtc gacacaaagc cctctcgacc tgttgctccc actttactgt agttgtactc ttttttgtgc cttgcatttt cacctacatg cgtcctgtgg tcacctaccc tgtggataag ttggtgactg tgttctttgc aatcctcact cctatgttaa atcctatcat ttacacagtg aggaactcgg aggtgaaaaa tgccatgagg agtctgttga agagagtaat ttag <210> 598 <211> 307 <212> PRT <213> Canis familiaris

300

360

420

480

540

600

660

720

780

840

900

924 <400> 598

Met Asp His 1 Phe Thr 5 Pro Pro Asn Asn Val Thr Glu Phe Ile Leu Leu 10 15 Gly Leu Thr Gln Asn Pro His Leu Gln Lys Ile Phe Phe Val Val Phe 20 25 30 Leu Phe Ile Phe Leu Phe Thr Val Leu Ala Asn Leu Leu Ile Val Leu 35 40 45 Thr Ile Ser Leu Ser Ser Thr Leu Ser Ala Pro Met Tyr Phe Phe Leu 50 55 60 Thr Tyr Leu Ser Phe Ile Asp Ala Ser Tyr Thr Ser Val Thr Thr Pro 65 70 75 80

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Lys Met Ile Ile Asp 85 Leu Leu Tyr Gln Arg Arg Thr Ile Ser Leu Gly 90 95 Gly Cys Leu Thr Gln Leu Phe Val Glu His Phe Leu Gly Gly Ser Glu 100 105 110 Ile Ile Leu Leu Ile Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Lys Pro Leu His Tyr Met Thr Ile Met Arg His Gly Leu Cys Gln Leu 130 135 140 Leu Val Val Val Ala Trp Ile Gly Gly Ile Leu His Ala Thr Val Gln 145 150 155 160 Ile Leu Phe Met Val Asn Leu Pro Phe Cys Gly Pro Asn Val Ile Asp 165 170 175 His Phe Met Cys Asp Leu Phe Pro Leu Leu Lys Leu Ala Cys Ser Asp 180 185 190 Thr Tyr Arg Leu Gly Met Val Val Ala Ala Asn Ser Gly Ala Met Cys 195 200 205 Leu Leu Ile Phe Ser Met Leu Leu Ile Ser Tyr Thr Val Ile Leu Ser 210 215 220 Ser Leu Ser Ser His Gly Ser Glu Gly Arg His Lys Ala Leu Ser Thr 225 230 235 240 Cys Cys Ser His Phe Thr Val Val Val Leu Phe Phe Val Pro Cys Ile 245 250 255 Phe Thr Tyr Met Arg Pro Val Val Thr Tyr Pro Val Asp Lys Leu Val 260 265 270 Thr Val Phe Phe Ala Ile Leu Thr Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285

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Thr Val Arg Asn Ser Glu Val Lys Asn Ala Met Arg Ser Leu Leu Lys 290 295 300

Arg Val Ile 305 <210> 599 <211> 933 <212> DNA <213> Canis familiaris <400> 599 atgaaagaag aaaggatgaa tgtaactgta ttcattctaa tgggacttac ccagaatcct 60 cagatgcaga gaattctatt tttggtgtta cttgtcacct acattgtcac tgtctcaggc 120 aacctgctca ttgtggttac tataatccgc agccagactt tggactcccc aatgtatttc 180 ttcctggcct ttttgtctct gatagatgca tgttattcct cttccataat tcctaaaatg 240 ctagctgatc tgctctttga ttcaaaatct gtttccttta gtggctgcat gacacagctc 300 tttgtagaac atttcttagg agcttcagag attgtcctcc ttgtagtcat ggcctatgac 360 cgctatgtgg ccatctgtag acctctgcac tatgtgacca tcatgaacca tcacacatgc 420 tgcctcttcg tggggatgtg ttgggtagtg ggttttctcc actccattgg acagattctc 480 gttactttct ggctcccctt ctgtggtccc aacatcatgg atcacttcat gtgtgacatt 540 ttccccctga tacaacttgc ctgcactgac actttctttg ttggtttctt ggttgctgcc 600 aatggtggag caatttctgt gatcaccttt gtgatgttat tgatatccta tgtggtcatc 660 ctgtgctcct tgaagactca cagttctgtg gggaagaaaa aggccctctc tacctgtagc 720 tctcacatca cagttgttgt cttgttcttt gtgccctgta tttttatgta tctgcgacca 780 gtagctactt ttccaatgga taaagccata gctgtattct atactcttgt tacccccatg 840 ttaaaccctg tcatctacac agtaaggaat acagaggtaa aaaatgccat gagaatgtta 900 ttaaccagga atgcaatttc agataataaa tga 933 <210> 600 <211> 310 <212> PRT <213> Canis familiaris

Page 668

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<400> 600 Met 1 Lys Glu Glu Arg Met Asn Val Thr Val Phe Ile Leu Met Gly Leu 5 10 15 Thr Gln Asn Pro Gln Met Gln Arg Ile Leu Phe Leu Val Leu Leu Val 20 25 30 Thr Tyr Ile Val Thr Val Ser Gly Asn Leu Leu Ile Val Val Thr Ile 35 40 45 Ile Arg Ser Gln Thr Leu Asp Ser Pro Met Tyr Phe Phe Leu Ala Phe 50 55 60 Leu Ser Leu Ile Asp Ala Cys Tyr Ser Ser Ser Ile Ile Pro Lys Met 65 70 75 80 Leu Ala Asp Leu Leu Phe Asp Ser Lys Ser Val Ser Phe Ser Gly Cys 85 90 95 Met Thr Gln Leu Phe Val Glu His Phe Leu Gly Ala Ser Glu Ile Val 100 105 110 Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro 115 120 125 Leu His Tyr Val Thr Ile Met Asn His His Thr Cys Cys Leu Phe Val 130 135 140 Gly Met Cys Trp Val Val Gly Phe Leu His Ser Ile Gly Gln Ile Leu 145 150 155 160 Val Thr Phe Trp Leu Pro Phe Cys Gly Pro Asn Ile Met Asp His Phe 165 170 175 Met Cys Asp Ile Phe Pro Leu Ile Gln Leu Ala Cys Thr Asp Thr Phe 180 185 190 Phe Val Gly Phe Leu Val Ala Ala Asn Gly Gly Ala Ile Ser Val Ile 195 200 205

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Thr Phe Val 210 Met Leu Leu Ile Ser 215 Tyr Val Val Ile 220 Leu Cys Ser Leu Lys Thr His Ser Ser Val Gly Lys Lys Lys Ala Leu Ser Thr Cys Ser 225 230 235 240 Ser His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Met 245 250 255 Tyr Leu Arg Pro Val Ala Thr Phe Pro Met Asp Lys Ala Ile Ala Val 260 265 270 Phe Tyr Thr Leu Val Thr Pro Met Leu Asn Pro Val Ile Tyr Thr Val 275 280 285 Arg Asn Thr Glu Val Lys Asn Ala Met Arg Met Leu Leu Thr Arg Asn 290 295 300 Ala Ile Ser Asp Asn Lys

305 310

<210> 601 <211> 954 <212> DNA <213> Canis familiaris <400> 601 atgggaaata gaaacaatgt gacagagttt gtcctcctgg ggctcacaca ggacctggag 60 gggcaaaaat ttctgtttat cccattctta ctcatctaca ttgtgacaat agtgggtaat 120 ttgcttatca tggtgaccat tatggccagc cagtctctgg gttctcccat gtatttcttt 180 ctggcttatt tgtcatttat agatgctact tattctactg tcattgctcc caagatgatt 240 gcagacttgc tctatgagaa gaagactatt tccttccagg cttgtatgac tcaagtcttt 300 ctagatcact tatttgctgg tgctgaagtc attcttctgg tggtgatggc ctatgaccga 360 tatgtggcca tctgtaaacc acttcattat ctaatcatca tgaatcggag gacatgtgtt 420 cttatgctgc taggggcctg gactggaggc ttcctgcact cattggttca atttcttttt 480 atttatcagc tccctttctg tggccccaat gtcattgaca acttcgtgtg tgatatgtat 540

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cccttattga aacttgcttg caccaatacc tacctcattg gaatttctat gatagctaat 600 ggaggagcca tttgcactgc cattttcttc attcttctag tttcctatgg gatcatatta 660 tactccctta agactcatag tttagatggg aaactcaaag ccttctacac ctgtgcatcc 720 catataactg tggttatttt attctttgtt ccctgtatct tcctgtatgc aagacctaat 780 actacctttc ccatcgataa attcatgact gtgtttttaa cattcataac tcccatgctg 840 aaccccttaa tctatactct gaggaatgca gaaataaaaa atgccatgtg gaaactttgg 900 agtaaaaacg tgaccttagt tgatagagag ttgtattgct catgcaaaat atga 954

<210> 602 <211> 317 <212> PRT <213> Canis familiaris <400> 602

Met Gly Asn Arg Asn Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr 1 5 10 15 Gln Asp Leu Glu Gly Gln Lys Phe Leu Phe Ile Pro Phe Leu Leu Ile 20 25 30 Tyr Ile Val Thr Ile Val Gly Asn Leu Leu Ile Met Val Thr Ile Met 35 40 45 Ala Ser Gln Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu 50 55 60 Ser Phe Ile Asp Ala Thr Tyr Ser Thr Val Ile Ala Pro Lys Met Ile 65 70 75 80 Ala Asp Leu Leu Tyr Glu Lys Lys Thr Ile Ser Phe Gln Ala Cys Met 85 90 95 Thr Gln Val Phe Leu Asp His Leu Phe Ala Gly Ala Glu Val Ile Leu 100 105 110 Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125

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His Tyr Leu Ile Ile Met Asn Arg Arg Thr Cys Val 140 Leu Met Leu Leu 130 135 Gly Ala Trp Thr Gly Gly Phe Leu His Ser Leu Val Gln Phe Leu Phe 145 150 155 160 Ile Tyr Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Asn Phe Val 165 170 175 Cys Asp Met Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asn Thr Tyr Leu 180 185 190 Ile Gly Ile Ser Met Ile Ala Asn Gly Gly Ala Ile Cys Thr Ala Ile 195 200 205 Phe Phe Ile Leu Leu Val Ser Tyr Gly Ile Ile Leu Tyr Ser Leu Lys 210 215 220 Thr His Ser Leu Asp Gly Lys Leu Lys Ala Phe Tyr Thr Cys Ala Ser 225 230 235 240 His Ile Thr Val Val Ile Leu Phe Phe Val Pro Cys Ile Phe Leu Tyr 245 250 255 Ala Arg Pro Asn Thr Thr Phe Pro Ile Asp Lys Phe Met Thr Val Phe 260 265 270 Leu Thr Phe Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Ile Lys Asn Ala Met Trp Lys Leu Trp Ser Lys Asn Val 290 295 300 Thr Leu Val Asp Arg Glu Leu Tyr Cys Ser Cys Lys Ile 305 310 315

<210> 603 <211> 945

Page 672

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 603

atgggaaata ataatgtgac agaatttgtc ctccttggcc tcactcagga tcctgagggg 60 cagaaagcat tatttgtcat gattttactc atctacattg tgacaatggt gggcaaccta 120 ctcattgtag tgactgtttt tggcagcccc tctctgggct cccccatgta ctttttcctt 180 gcctatctgt cacttatgga tgctgtttat tccactgtca tttcacccaa attgattata 240 gacttactct gtgacaaaaa gacaatttct ttcccagctt gcatgggtca gctctttcta 300 gaacacttct ttgggggttc tgaggtcttc cttctggtca tgatggccta tgatcgctat 360 gtggccatct gtaggccact gcattacctg actgttatga atcgacaggt ttgcatcctg 420 ctgatagtgg tggcctggat tggaggtctt gtgcactcta tggttcagct tctctttgtg 480 tacagcctcc cattttgtgg ccccaatgtc attgatcact ttatctgtga catgtaccca 540 ttattagaac ttgcctgcac tgacacctac ttaataggcc tcactgtgat tgccaacggt 600 ggagcaatct gtatggtcat ctttatcctt ctactcatct cctatggagt cattctaaat 660 tctcttaaaa gtcacagtcc agaagggagg cgcaaagccc tgtctacctg cagttcccac 720 accacagtgg ttgtcctttt ttttgttccc tgcattttca tgtatgttag acctgtttct 780 aacttgccca ttgataagtc tgtaactctg gtttatacag ttatcactcc catgttaaat 840 cctttaatat ataccttgag aaattcagag atgaaaaatg ctatggaaaa attctggtgt 900 aaaaatttaa caaaaggtag aataagaatg tgtcacctaa actga 945

<210> 604 <211> 314 <212> PRT <213> Canis familiaris <400> 604

Met Gly Asn Asn Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr Gln 1 5 10 15 Asp Pro Glu Gly Gln Lys Ala Leu Phe Val Met Ile Leu Leu Ile Tyr 20 25 30 Ile Val Thr Met Val Gly Asn Leu Leu Ile Val Val Thr Val Phe Gly

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Ser Pro Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu Ser 50 55 60 Leu Met Asp Ala Val Tyr Ser Thr Val Ile Ser Pro Lys Leu Ile Ile 65 70 75 80 Asp Leu Leu Cys Asp Lys Lys Thr Ile Ser Phe Pro Ala Cys Met Gly 85 90 95 Gln Leu Phe Leu Glu His Phe Phe Gly Gly Ser Glu Val Phe Leu Leu 100 105 110 Val Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu His 115 120 125 Tyr Leu Thr Val Met Asn Arg Gln Val Cys Ile Leu Leu Ile Val Val 130 135 140 Ala Trp Ile Gly Gly Leu Val His Ser Met Val Gln Leu Leu Phe Val 145 150 155 160 Tyr Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Ile Cys 165 170 175 Asp Met Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr Leu Ile 180 185 190 Gly Leu Thr Val Ile Ala Asn Gly Gly Ala Ile Cys Met Val Ile Phe 195 200 205 Ile Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu Asn Ser Leu Lys Ser 210 215 220 His Ser Pro Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser Ser His 225 230 235 240 Thr Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Met Tyr Val

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255

069269_0225_SL.TXT

250

Arg Pro Val Ser Asn Leu Pro Ile Asp 265 Lys Ser Val Thr Leu 270 Val Tyr 260 Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn 275 280 285 Ser Glu Met Lys Asn Ala Met Glu Lys Phe Trp Cys Lys Asn Leu Thr 290 295 300 Lys Gly Arg Ile Arg Met Cys His Leu Asn 305 310

<210> 605 <211> 918 <212> DNA <213> Canis familiaris <400> 605 atggaacaca ggaacaatgt gactgagttt gtcctcttgg ggctcaccca gagcatccaa ggtcagaaaa tattatttgt tgtgttcttg ctcatctaca tcgtgacaat ggtgggcaac ctactcattg tggtaactgt ggtggtcagc ccaagcctgg atgcccctat gtacttcttt cttggttact tatcatttat ggatgctgtg tattctacta cagttactcc aaatatgatc atagacttac tctatgagaa gaaaaccatt tccttccaag cttgcatgtc ccagctcttt atagggcact tatttggtgg tgctgagatt ttactcctgg tggtcatggc ctatgaccgc tacgtggcca tctgcaaacc cttgcattat ttgacgatca tgaatcaacg agtgtgtgtt ctgttgctgt tgttggcttg gtttggaggg tttttgcatg ctgtggttaa acttttctcc atttacaacc ttcctttctg tggtcccaat gtcatcgacc acttcatctg tgacatgtac ccattactaa aacttgcctg cactgacact tatgttattg gcctcactgt ggttgccaat gatgggacta tctgtgtcgt tatctttttg gtcctactca tctcctacgg agtcattctg tacaccctga aggctcttag tcaggaaggg aggcgcaaag ccttatccac ctgtgggtcc catattacag tggtggtcct cttctttgtc ccctgcattt ttatgtatgt gagacctcct tctaccttac ccattgataa attcttgact gtgttttaca cagttatcac ccctatgtta Page 675

120

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420

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840

069269_0225_SL.TXT aaccccctaa tctatactct gagaaatgga gagatgaaaa atgccatgaa aaagttgtgg accagaagaa gaaaatga

900

918 <210> 606 <211> 305 <212> PRT <213> Canis familiaris <400> 606

Met Glu 1 His Arg Asn Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr 5 10 15 Gln Ser Ile Gln Gly Gln Lys Ile Leu Phe Val Val Phe Leu Leu Ile 20 25 30 Tyr Ile Val Thr Met Val Gly Asn Leu Leu Ile Val Val Thr Val Val 35 40 45 Val Ser Pro Ser Leu Asp Ala Pro Met Tyr Phe Phe Leu Gly Tyr Leu 50 55 60 Ser Phe Met Asp Ala Val Tyr Ser Thr Thr Val Thr Pro Asn Met Ile 65 70 75 80 Ile Asp Leu Leu Tyr Glu Lys Lys Thr Ile Ser Phe Gln Ala Cys Met 85 90 95 Ser Gln Leu Phe Ile Gly His Leu Phe Gly Gly Ala Glu Ile Leu Leu 100 105 110 Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Thr Ile Met Asn Gln Arg Val Cys Val Leu Leu Leu Leu 130 135 140 Leu Ala Trp Phe Gly Gly Phe Leu His Ala Val Val Lys Leu Phe Ser 145 150 155 160

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Ile Tyr Asn Leu Pro Phe Cys Gly Pro Asn 170 Val Ile Asp His Phe 175 Ile 165 Cys Asp Met Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr Tyr Val 180 185 190 Ile Gly Leu Thr Val Val Ala Asn Asp Gly Thr Ile Cys Val Val Ile 195 200 205 Phe Leu Val Leu Leu Ile Ser Tyr Gly Val Ile Leu Tyr Thr Leu Lys 210 215 220 Ala Leu Ser Gln Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Met Tyr 245 250 255 Val Arg Pro Pro Ser Thr Leu Pro Ile Asp Lys Phe Leu Thr Val Phe 260 265 270 Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Gly Glu Met Lys Asn Ala Met Lys Lys Leu Trp Thr Arg Arg Arg 290 295 300 Lys 305 <210> 607 <211> 930 <212> DNA <213> Canis familiaris <400> 607 atggaaccaa gaaacaatgt aacttacttt gtcctcctgg gcctcacaca ggatcctaag gaacagaagg tcctttttat tatgttcttg ctcttctata ttttgactgt ggtgggcaac ctgctcattg tggtgactgt aactgtcagt aagaccctgg gctcacctat gtactttttt

120

180

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cttgctaact tatcttttat ggatgtcatt tattcctctt gcatttcccc tagattgatt 240 tcagagtttt tctttcaaaa aagtaccata tccttccaat cctgtatgac tcagctcttt 300 atagatcacc tttttggtgg atcagaggtc tttcttcttt tggtgatggc ctatgaccgc 360 tatgtggcca tctgtaagcc tttgcattat ttggttatca tgaggcaatg ggtatgtgtt 420 gtgctgcttg tggtatcctg ggttggagga tttctgcatt cagtaattca agtgagcact 480 atttatgggc tcccattctg tggccccaat gtcatagatc attttttctg tgatatgtac 540 cccttactga aactggtctg tactgaaacg tatgttgctg gcctcttagt tgctgccaat 600 ggaggggtga tatgctctat tgtgtttgtg ctcttgctca tttcttatgg tgtcatcttg 660 cactctctaa agaaccttag tccagagggg aggcggaaag ccctccagac ctgtggttcc 720 catatcactg tagtggtctt cttctttgtt ccatgtattt tcatgtatgc aagacctgct 780 aagaccttcc ccattgacaa atcattgact gtgttttata cagtcataac ccccatgcta 840 aacccactga tctacaccct gagaaattct gagatgataa atgctatgaa gaagctttgg 900 aggagaaatg tcatatcaag tagtcaataa 930

<210> 608 <211> 309 <212> PRT <213> Canis familiaris <400> 608

Met Glu Pro Arg Asn Asn Val Thr Tyr Phe Val Leu Leu Gly Leu Thr 1 5 10 15 Gln Asp Pro Lys Glu Gln Lys Val Leu Phe Ile Met Phe Leu Leu Phe 20 25 30 Tyr Ile Leu Thr Val Val Gly Asn Leu Leu Ile Val Val Thr Val Thr 35 40 45 Val Ser Lys Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Asn Leu 50 55 60 Ser Phe Met Asp Val Ile Tyr Ser Ser Cys Ile Ser Pro Arg Leu Ile 65 70 75 80

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Ser Glu Phe Phe Phe 85 Gln Lys Ser Thr Ile Ser Phe Gln Ser Cys Met 90 95 Thr Gln Leu Phe Ile Asp His Leu Phe Gly Gly Ser Glu Val Phe Leu 100 105 110 Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Val Ile Met Arg Gln Trp Val Cys Val Val Leu Leu Val 130 135 140 Val Ser Trp Val Gly Gly Phe Leu His Ser Val Ile Gln Val Ser Thr 145 150 155 160 Ile Tyr Gly Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Phe 165 170 175 Cys Asp Met Tyr Pro Leu Leu Lys Leu Val Cys Thr Glu Thr Tyr Val 180 185 190 Ala Gly Leu Leu Val Ala Ala Asn Gly Gly Val Ile Cys Ser Ile Val 195 200 205 Phe Val Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys 210 215 220 Asn Leu Ser Pro Glu Gly Arg Arg Lys Ala Leu Gln Thr Cys Gly Ser 225 230 235 240 His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Met Tyr 245 250 255 Ala Arg Pro Ala Lys Thr Phe Pro Ile Asp Lys Ser Leu Thr Val Phe 260 265 270 Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285

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Asn Ser Glu Met Ile Asn Ala Met Lys Lys Leu Trp Arg Arg Asn Val 290 295 300

Ile Ser Ser Ser Gln

305 <210> 609 <211> 1065 <212> DNA <213> Canis familiaris <400> 609

atggaaccaa gaaacaacgt aacttacttt gtcctcttgg gcctcacaca ggatcctaag 60 gaacagaagg tcctttgttt tatgttcttg ctcttctata ttttgacagt ggtgggcaac 120 ttgctcattg tgttgactat agctctcagt aagaccctgg gctcacctat gtacttgttt 180 cttgctaacc tatcatttat ggatgtcact tattcctctt gcatttcccc cagattgatt 240 tcaaccttgt tctttgggga aaataccata tccttccatt cttgtatgac acagttattt 300 atggagcacc tttttggtgg atcagaggtc tttcttctgc tggtgatggc ctatgaccgc 360 tatgtggcca tctgtaagcc tttgcattat ttggttatca tgaggcaatg ggtgtgtgtt 420 gtgctgctgg tggtatcctg gattggaggt tttctgcatt cagtaattca agttagcacc 480 atttatgggc tcccattttg tggtcccaat gtcattgatc atttttcctg tgacatgtac 540 cccttactag aattggtctg cactagcacc catgtcattg ggctgttagt tgtagccaat 600 ggagggatga tctgcactat tgtgtttgtg ttcttgctca tctcttatgg tgtcatcttg 660 cactctctaa agaaccttag tccagagggg aagcggaaag ccctccagac ctgtggctcc 720 cacatcactg tggtggtctt cttctttgtt ccatgtattt tcatgtatgc aagacctgct 780 aagaccttct acattgacaa atccttgagt gtgttttata cagtcataac ccccatgctg 840 aacccactga tctacactct gagaaattct gagatgacaa atgctataaa gaagctctgg 900 ggatccctgg gtggcgcagc ggtttggcgc ctgcctttgg cccagggcgc gatcctggag 960 accagggatc gaatcccaca tcgggctccc ggtgcatgga gcctgcttct ccctctgcct 1020 gtgtctctgc ctctctctct ctcactgtgt gcctatcata aataa 1065

Page 680

069269_0225_SL.TXT <210> 610 <211> 354 <212> PRT <213> Canis familiaris <400> 610

Met Glu Pro Arg Asn Asn Val Thr Tyr Phe Val Leu Leu Gly Leu Thr 1 5 10 15 Gln Asp Pro Lys Glu Gln Lys Val Leu Cys Phe Met Phe Leu Leu Phe 20 25 30 Tyr Ile Leu Thr Val Val Gly Asn Leu Leu Ile Val Leu Thr Ile Ala 35 40 45 Leu Ser Lys Thr Leu Gly Ser Pro Met Tyr Leu Phe Leu Ala Asn Leu 50 55 60 Ser Phe Met Asp Val Thr Tyr Ser Ser Cys Ile Ser Pro Arg Leu Ile 65 70 75 80 Ser Thr Leu Phe Phe Gly Glu Asn Thr Ile Ser Phe His Ser Cys Met 85 90 95 Thr Gln Leu Phe Met Glu His Leu Phe Gly Gly Ser Glu Val Phe Leu 100 105 110 Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Val Ile Met Arg Gln Trp Val Cys Val Val Leu Leu Val 130 135 140 Val Ser Trp Ile Gly Gly Phe Leu His Ser Val Ile Gln Val Ser Thr 145 150 155 160 Ile Tyr Gly Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Ser 165 170 175 Cys Asp Met Tyr Pro Leu Leu Glu Leu Val Cys Thr Ser Thr His Val 180 185 190

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Ile Gly Leu Leu Val Val Ala Asn Gly Gly Met Ile Cys Thr Ile Val 195 200 205 Phe Val Phe Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys 210 215 220 Asn Leu Ser Pro Glu Gly Lys Arg Lys Ala Leu Gln Thr Cys Gly Ser 225 230 235 240 His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Met Tyr 245 250 255 Ala Arg Pro Ala Lys Thr Phe Tyr Ile Asp Lys Ser Leu Ser Val Phe 260 265 270 Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Met Thr Asn Ala Ile Lys Lys Leu Trp Gly Ser Leu Gly 290 295 300 Gly Ala Ala Val Trp Arg Leu Pro Leu Ala Gln Gly Ala Ile Leu Glu 305 310 315 320 Thr Arg Asp Arg Ile Pro His Arg Ala Pro Gly Ala Trp Ser Leu Leu 325 330 335 Leu Pro Leu Pro Val Ser Leu Pro Leu Ser Leu Ser Leu Cys Ala Tyr 340 345 350

His Lys <210> 611 <211> 930 <212> DNA <213> Canis familiaris <400> 611

Page 682

069269_0225_SL.TXT atggaaccaa gaaacaacgt aacttacttt gtcctcttgg gcctcacaca ggatcctaag 60 gaacagaagg tcctttgtgt tatgttcttg ctcttctata ttttgacagt ggtgggcaac 120 ttgctcattg tgttgactat agctctcagt aagaccctgg gctcacctat gtacttgttt 180 cttgctaacc tatcatttat ggatgtcact tattcctctt gcatttcccc cagattgatt 240 tcaaccttgt tctttgggga aaataccata tccttccatt cttgtatgac acagctattt 300 acagagcacc tttttggtgg atcagaggtc tttcttctgc tggtgatggc ctatgaccgc 360 tatgtggcca tctgtaagcc tttgcattat ttggttatca tgaggcaatg ggtgtgtgtt 420 gtgctgctgg tggtatcctg gattggaggt tttctgcatt cagtaattca agttagcacc 480 atttatgggc tcccattttg tggtcccaat gttgttgatc atttcatctg tgaaatgtac 540 cctttactgg aactggtctg tactgacaca tatgtcattg ggctattagt tgtagccaat 600 ggagggatga tctgcactat tgtgtttgcg ttcttactca tctcttatgg tgtcatcttg 660 cactctctaa agaaccttag tccagagggg aagcggaaag ccctccagac ctgtggctcc 720 cacatcaccg tggtggtctt cttctttgtt ccatgtattt tcatgtatgt aagacctgct 780 aagaccttcc ccattgacaa atccctgagt gtgtttttta cagtcataac cccaatgctg 840 aacccgttga tctacacttt gcgaaattct gagatgacaa atgctatgaa gaagctctgg 900 aggagaaatg ttatatcttt tagtagataa 930 <210> 612 <211> 309 <212> PRT <213> Canis familiaris <400> 612

Met 1 Glu Pro Arg Asn Asn Val Thr Tyr Phe Val Leu Leu Gly Leu Thr 5 10 15 Gln Asp Pro Lys Glu Gln Lys Val Leu Cys Val Met Phe Leu Leu Phe 20 25 30 Tyr Ile Leu Thr Val Val Gly Asn Leu Leu Ile Val Leu Thr Ile Ala 35 40 45 Leu Ser Lys Thr Leu Gly Ser Pro Met Tyr Leu Phe Leu Ala Asn Leu

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50 55 60

Ser 65 Phe Met Asp Val Thr Tyr Ser Ser Cys Ile Ser Pro Arg Leu Ile 70 75 80 Ser Thr Leu Phe Phe Gly Glu Asn Thr Ile Ser Phe His Ser Cys Met 85 90 95 Thr Gln Leu Phe Thr Glu His Leu Phe Gly Gly Ser Glu Val Phe Leu 100 105 110 Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Val Ile Met Arg Gln Trp Val Cys Val Val Leu Leu Val 130 135 140 Val Ser Trp Ile Gly Gly Phe Leu His Ser Val Ile Gln Val Ser Thr 145 150 155 160 Ile Tyr Gly Leu Pro Phe Cys Gly Pro Asn Val Val Asp His Phe Ile 165 170 175 Cys Glu Met Tyr Pro Leu Leu Glu Leu Val Cys Thr Asp Thr Tyr Val 180 185 190 Ile Gly Leu Leu Val Val Ala Asn Gly Gly Met Ile Cys Thr Ile Val 195 200 205 Phe Ala Phe Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys 210 215 220 Asn Leu Ser Pro Glu Gly Lys Arg Lys Ala Leu Gln Thr Cys Gly Ser 225 230 235 240 His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Met Tyr 245 250 255 Val Arg Pro Ala Lys Thr Phe Pro Ile Asp Lys Ser Leu Ser Val Phe

Page 684

260

069269_0225_SL.TXT 265 270

Phe Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Met Thr Asn Ala Met Lys Lys Leu Trp Arg Arg Asn Val 290 295 300 Ile Ser Phe Ser Arg

305 <210> 613 <211> 939 <212> DNA <213> Canis familiaris <400> 613

atgcagaaga tggaactaag aaacaatgta acttactttg tcctcttggg cctcacacag 60 aatccaaagg aacagaaggt cctttttgtt atattcttgc tcttctatat tttgactgtg 120 gtgggcaact tgctcatttt ggtgactata tctctcagta agaccctggg ctcacctatg 180 tacttgtttc ttgctaactt atcatttatg gatgtcattt attcatcttc tatatcccct 240 agattgattt cagacttatt ctttgcgaaa aataccatat cgttccattc ttgtatgatt 300 cagctcttta cagagcacct ttttggtgga acagaaatat ttcttctgct ggtgatggcc 360 tatgaccgct atgtggccat ctgtaagccc ttgcattatt tggttatcat gaagcaatgg 420 gtgtgtgttg tgctgctggt ggtatcctgg gttggaggtt ttctgcactc agtaattcaa 480 cttagcacta ttcatgggct cccattctgt gggcccaatg tcatcgatca ttttttctgt 540 gacatgtacc ctttactgaa actggtctgt actgacacat atgttattgg gttgttagtt 600 gtagccaatg gagggatgat ctgcactatt gtgttttcat tcttgctcat ctcttatggt 660 atcatcttgc actctctaaa gaaccttagt ccagagggga agcggaaagc cctccagacg 720 tgtggctccc acatcactgt ggtggtcttt ttcttcgttc catgtatttt catgtatgca 780 agacctgcta agacattccc cattgacaaa tccctgagtg tgttttatac agtcataacc 840 ccaatgctga acccgttgat ctacactttg agaaattctg agatgacaaa tgctatgaag 900 aagctatgga gaagaaatac tatatctttc agtagataa 939

Page 685

069269_0225_SL.TXT <210> 614 <211> 312 <212> PRT <213> Canis familiaris <400> 614

Met 1 Gln Lys Met Glu 5 Leu Arg Asn Asn Val Thr Tyr Phe Val Leu Leu 10 15 Gly Leu Thr Gln Asn Pro Lys Glu Gln Lys Val Leu Phe Val Ile Phe 20 25 30 Leu Leu Phe Tyr Ile Leu Thr Val Val Gly Asn Leu Leu Ile Leu Val 35 40 45 Thr Ile Ser Leu Ser Lys Thr Leu Gly Ser Pro Met Tyr Leu Phe Leu 50 55 60 Ala Asn Leu Ser Phe Met Asp Val Ile Tyr Ser Ser Ser Ile Ser Pro 65 70 75 80 Arg Leu Ile Ser Asp Leu Phe Phe Ala Lys Asn Thr Ile Ser Phe His 85 90 95 Ser Cys Met Ile Gln Leu Phe Thr Glu His Leu Phe Gly Gly Thr Glu 100 105 110 Ile Phe Leu Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Lys Pro Leu His Tyr Leu Val Ile Met Lys Gln Trp Val Cys Val Val 130 135 140 Leu Leu Val Val Ser Trp Val Gly Gly Phe Leu His Ser Val Ile Gln 145 150 155 160 Leu Ser Thr Ile His Gly Leu Pro Phe Cys Gly Pro Asn Val Ile Asp 165 170 175

Page 686

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His Phe Phe Cys 180 Asp Met Tyr Pro Leu Leu Lys 185 Leu Val Cys Thr Asp 190 Thr Tyr Val Ile Gly Leu Leu Val Val Ala Asn Gly Gly Met Ile Cys 195 200 205 Thr Ile Val Phe Ser Phe Leu Leu Ile Ser Tyr Gly Ile Ile Leu His 210 215 220 Ser Leu Lys Asn Leu Ser Pro Glu Gly Lys Arg Lys Ala Leu Gln Thr 225 230 235 240 Cys Gly Ser His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile 245 250 255 Phe Met Tyr Ala Arg Pro Ala Lys Thr Phe Pro Ile Asp Lys Ser Leu 260 265 270 Ser Val Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Thr Leu Arg Asn Ser Glu Met Thr Asn Ala Met Lys Lys Leu Trp Arg 290 295 300 Arg Asn Thr Ile Ser Phe Ser Arg

305 310 <210> 615 <211> 933 <212> DNA <213> Canis familiaris <400> 615 aaggaaatgg aaccaaagaa caatgttact gactttgtcc tcttgggcct cacacagaat ccaaaggaac agaaggtcct ttttgttata ttcttgctct tctatatttt gaccatggtg gacaacctac tcattgtggt gactgtttct ttcagtaaga ccctgggctc acctatgtac ttttttcttg ccagcttatc atttatggac gtcatttatt cctcttctat ttctcctgaa ctgctttcaa atttgttctt tggggaaaat atcatatcct tccaatcttg tatgatccag

120

180

240

300

Page 687

069269_0225_SL.TXT

ctgtttacag agcacttttt tggtggatca gaggtctttc ttctgctggt gatggcctat 360 gaccgctatg tggccatctg taagcccttg cattatttgg ttatcatgag gcaatgagta 420 tgtgttgtgc tgctggtgat atcctgggtt ggacgttttc tgcattcagt aattaaagtt 480 agcactattt agaggctccc attctgtggc cccaatgtca tcgatcattt tttctgtgat 540 atgtacccct tactgaaact ggtctgtact gacacccatg tcattggcat cttagttgct 600 gccaatggaa ggatgatctg cactattgtg cttgtgctcg tgctcatctc ttatggtgtc 660 atcttgcact ctctaaagaa ccttagttca gaggggaggc ggaaagccct ccagacctgt 720 ggttcccatg tcactgtggt ggtcttcttc tttgttccat gtattttcat gtatttaaga 780 cctgctaaga ccttcccccc tgacaaatcc ctgagtgtgt tttacacagt cataaccccc 840 atgctgaacc cactgatcta cactctgaga aattctgaga tggcaaatgc tatgaagaag 900 ctctggagca gaagtatcat atcttgcagc aaa 933

<210> 616 <211> 138 <212> PRT <213> Canis familiaris <400> 616

Lys Glu Met Glu Pro Lys Asn Asn Val Thr Asp Phe Val Leu Leu Gly 1 5 10 15 Leu Thr Gln Asn Pro Lys Glu Gln Lys Val Leu Phe Val Ile Phe Leu 20 25 30 Leu Phe Tyr Ile Leu Thr Met Val Asp Asn Leu Leu Ile Val Val Thr 35 40 45 Val Ser Phe Ser Lys Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala 50 55 60 Ser Leu Ser Phe Met Asp Val Ile Tyr Ser Ser Ser Ile Ser Pro Glu 65 70 75 80 Leu Leu Ser Asn Leu Phe Phe Gly Glu Asn Ile Ile Ser Phe Gln Ser 85 90 95

Page 688

069269_0225_SL.TXT

Cys Met Ile Gln 100 Leu Phe Thr Glu His Phe Phe Gly Gly Ser Glu Val 105 110 Phe Leu Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Val Ile Met Arg Gln 130 135

<210> 617 <211> 933 <212> DNA <213> Canis familiaris <400> 617

atgcatatga taaaaacaaa cttcactgtg actgagtttg tgttcttggg gctgtcatct 60 cagccaaaga tgcagctcat tctttttatt atgttcttgt tcttctattt attaacagtt 120 gtggggaata ttataattat cactattatc cagatagaac ctcgtctcca aacccccatg 180 tacttcttcc ttactaattt gtcctttctg gacatctgct acacatccac caatgtccca 240 caaatgctgt ccaacatgat gggaaaaaag accatcccct tctctagctg tgctactcag 300 atgtacttct ccctttcctt tggaatgatt gaatgtgttc tccttggggt catggcttat 360 gacagatatg tagccatttg tcatcctctc cattatattg tcattatgaa ccaaagcatc 420 tgtgtccaat tggcagccat ttcttggtcc agtagcttcc tgagttccat ggttatcaat 480 gtcctcacct tgagtttgcc ctactgtggg cccaatgtcc tgaatcactt tttttgtgag 540 gttccttctg tcttgaggtt agcttgcact gacacctcat ttacagagct ggttgttttt 600 atctttagta tcatcattgt cttcatccct tttctcctca ttgttgtttc ctatgcccga 660 atccttctat cagttctcag gatacggtca gcctctggga ggcacaaggc actgtccact 720 tgtgtctccc atctgacagt ggtggcctta ttctatggaa ctgccatctt catatacatg 780 agaccccagt cgaagtcctc cagggctggg ggcaagatca ttgccgtgtt ctacactgtg 840 atcacaccca tgctcaaccc cttgatctat agcctaagga accaggatgt gaaaggagct 900 ttaaggagag ctattgcaaa acggaggaca tga 933

Page 689

069269_0225_SL.TXT <210> 618 <211> 310 <212> PRT <213> Canis familiaris <400> 618

Met His Met Ile Lys Thr Asn Phe Thr Val Thr Glu Phe Val Phe Leu 1 5 10 15 Gly Leu Ser Ser Gln Pro Lys Met Gln Leu Ile Leu Phe Ile Met Phe 20 25 30 Leu Phe Phe Tyr Leu Leu Thr Val Val Gly Asn Ile Ile Ile Ile Thr 35 40 45 Ile Ile Gln Ile Glu Pro Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu 50 55 60 Thr Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Thr Asn Val Pro 65 70 75 80 Gln Met Leu Ser Asn Met Met Gly Lys Lys Thr Ile Pro Phe Ser Ser 85 90 95 Cys Ala Thr Gln Met Tyr Phe Ser Leu Ser Phe Gly Met Ile Glu Cys 100 105 110 Val Leu Leu Gly Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Ile Val Ile Met Asn Gln Ser Ile Cys Val Gln Leu 130 135 140 Ala Ala Ile Ser Trp Ser Ser Ser Phe Leu Ser Ser Met Val Ile Asn 145 150 155 160 Val Leu Thr Leu Ser Leu Pro Tyr Cys Gly Pro Asn Val Leu Asn His 165 170 175 Phe Phe Cys Glu Val Pro Ser Val Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190

Page 690

069269_0225_SL.TXT

Ser Phe Thr Glu Leu Val Val Phe Ile Phe Ser Ile Ile Ile Val Phe 195 200 205 Ile Pro Phe Leu Leu Ile Val Val Ser Tyr Ala Arg Ile Leu Leu Ser 210 215 220 Val Leu Arg Ile Arg Ser Ala Ser Gly Arg His Lys Ala Leu Ser Thr 225 230 235 240 Cys Val Ser His Leu Thr Val Val Ala Leu Phe Tyr Gly Thr Ala Ile 245 250 255 Phe Ile Tyr Met Arg Pro Gln Ser Lys Ser Ser Arg Ala Gly Gly Lys 260 265 270 Ile Ile Ala Val Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Asp Val Lys Gly Ala Leu Arg Arg Ala 290 295 300 Ile Ala Lys Arg Arg Thr

305 310 <210> 619 <211> 915 <212> DNA <213> Canis familiaris <400> 619 atggatttga tggagaagat aatgtggaac ttcagaaatt gcaggcaact tgcttatcat tacttcttcc tgtcttactt aaaatgcttg ctgacactct caggtctttg ctgagcattt gaataatgtg acggaattca ttcatttgtt gtgtttttaa gatcaccatc agcaccagca gtcccttata gatggctgct tactatgaga aaaataatct ttttggtgct gctgagatta tcctcctggg cttgactcaa ttgtctactt ggtcactttg aggccctgga aacccccatg gttcttcctc catgacccct cttttagggg atgtatgact tcctccttac agtaatggcc

120

180

240

300

360

Page 691

069269_0225_SL.TXT tatgaccgct atgtggccat ctgcaaaccc ttgcgctaca caaccatcat gagtcaacag 420 gtctgtagcc tccttgtggg cgtggcctgg gctggaggct ttgtccatgc aaccattcag 480 atcttcttca cagtctggct gcctttctgt gggcccaatg ttatagatca tttcatgtgt 540 gacttaaacc ctttgttgaa acttgtctgc atggacactc atacccttgg tctctttgtt 600 gctgccaata gtgggttcat ctgtttgtta aactttctcc ttttggtggt ctcctacatg 660 gtcattttgc actccctagg gacctacagc ttggagggga gacgtaaagc cctctctacc 720 tgtgtctctc acatcactgt ggtcatttta ttctttgtgc cctgtatatt tgtctatttg 780 cgtccagcga tcaccttttc cattgataaa gctgtggctg tgttttacac catgataact 840 cctatgttaa accctttaat ctacaccttg agaaatgcag aggtgaaaaa tgctataaag 900 aagctctgga tctaa 915 <210> 620 <211> 304 <212> PRT <213> Canis familiaris <400> 620 Met Asp Leu Met Glu Lys Met Asn Asn Val Thr Glu Phe Ile Leu Leu 1 5 10 15 Gly Leu Thr Gln Asn Val Glu Leu Gln Lys Phe Ser Phe Val Val Phe 20 25 30 Leu Ile Val Tyr Leu Val Thr Leu Ala Gly Asn Leu Leu Ile Met Ile 35 40 45 Thr Ile Ser Thr Ser Lys Ala Leu Glu Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Tyr Leu Ser Leu Ile Asp Gly Cys Cys Ser Ser Ser Met Thr Pro 65 70 75 80 Lys Met Leu Ala Asp Thr Leu Thr Met Arg Lys Ile Ile Ser Phe Arg 85 90 95 Gly Cys Met Thr Gln Val Phe Ala Glu His Phe Phe Gly Ala Ala Glu

Page 692

100

069269_0225_SL.TXT 105 110

Ile Ile Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Lys Pro Leu Arg Tyr Thr Thr Ile Met Ser Gln Gln Val Cys Ser Leu 130 135 140 Leu Val Gly Val Ala Trp Ala Gly Gly Phe Val His Ala Thr Ile Gln 145 150 155 160 Ile Phe Phe Thr Val Trp Leu Pro Phe Cys Gly Pro Asn Val Ile Asp 165 170 175 His Phe Met Cys Asp Leu Asn Pro Leu Leu Lys Leu Val Cys Met Asp 180 185 190 Thr His Thr Leu Gly Leu Phe Val Ala Ala Asn Ser Gly Phe Ile Cys 195 200 205 Leu Leu Asn Phe Leu Leu Leu Val Val Ser Tyr Met Val Ile Leu His 210 215 220 Ser Leu Gly Thr Tyr Ser Leu Glu Gly Arg Arg Lys Ala Leu Ser Thr 225 230 235 240 Cys Val Ser His Ile Thr Val Val Ile Leu Phe Phe Val Pro Cys Ile 245 250 255 Phe Val Tyr Leu Arg Pro Ala Ile Thr Phe Ser Ile Asp Lys Ala Val 260 265 270 Ala Val Phe Tyr Thr Met Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Thr Leu Arg Asn Ala Glu Val Lys Asn Ala Ile Lys Lys Leu Trp Ile 290 295 300

<210> 621

Page 693

069269_0225_SL.TXT <211> 930 <212> DNA <213> Canis familiaris <400> 621 atggagatta ggaacaatgt gacagagttt gttctactgg ggcttacaga gaatccaaag 60 atgcagaaaa ttgtatttgt tgtgtttttt gtcatctaca ccatcactgt ggtaggtaat 120 atgctcattg tgatcaccat cactgccagc ccattgttgg gatcccccat gtaccttttc 180 ctggcctctc tctcctttat tgatgcctgc tactcctctg tcaatactcc caaactgatc 240 atagattcgc tccatgaaaa gaagactacc ctatacaatg gatgcatgac ccaaatattt 300 ggagaacatt tttttggagg tgctgaaggc atcctgctta ctgtgatggc ctatgaccgt 360 tatgtggcta tctgcaagcc actgcactac acaaccatca tgaatcggcg agtgtgtggc 420 ctgttaatgg gagtggtgtg ggttggaggc tttcttcatg caactataca gatcctcttc 480 attttccaat tacccttctg tgatccaaat gtcatagatc attttatgtg tgatctgaat 540 cctttgatca atcttgcctg cactgatacc cacactttag ggctcttcgt tgctgccaac 600 agtggattca tctgtctgtt aatcttcctc ctcttaatgg tctcctatgt ggtcattcta 660 tgctccctct ggaatcacaa cttggaggca aagcgcaaag ccctctccac ctgtgtctcc 720 cacatcacag tggttgtcct attctttgtg ccctgcatat ttgtgtacat gagacccgca 780 gctacgttat ccattaataa ggcagttgca gtgttctaca ctattataac tcccatgtta 840 aaccccttaa tctatacctt gagaaatgcc caaatgaaga atgctattag gaaattatgt 900 agtaagaaag ctatttcagg tgacaaataa 930 <210> 622 <211> 309 <212> PRT <213> Canis familiaris <400> 622

Met Glu Ile Arg Asn Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr 1 5 10 15

Glu Asn Pro Lys Met Gln Lys Ile Val Phe Val Val Phe Phe Val Ile 20 25 30

Page 694

Tyr Thr Ile 35 Thr Val Val Gly 069269_0225_SL.TXT Thr Ile Thr Asn Met 40 Leu Ile Val Ile 45 Ala Ser Pro Leu Leu Gly Ser Pro Met Tyr Leu Phe Leu Ala Ser Leu 50 55 60 Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Asn Thr Pro Lys Leu Ile 65 70 75 80 Ile Asp Ser Leu His Glu Lys Lys Thr Thr Leu Tyr Asn Gly Cys Met 85 90 95 Thr Gln Ile Phe Gly Glu His Phe Phe Gly Gly Ala Glu Gly Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Asn Arg Arg Val Cys Gly Leu Leu Met Gly 130 135 140 Val Val Trp Val Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe 145 150 155 160 Ile Phe Gln Leu Pro Phe Cys Asp Pro Asn Val Ile Asp His Phe Met 165 170 175 Cys Asp Leu Asn Pro Leu Ile Asn Leu Ala Cys Thr Asp Thr His Thr 180 185 190 Leu Gly Leu Phe Val Ala Ala Asn Ser Gly Phe Ile Cys Leu Leu Ile 195 200 205 Phe Leu Leu Leu Met Val Ser Tyr Val Val Ile Leu Cys Ser Leu Trp 210 215 220 Asn His Asn Leu Glu Ala Lys Arg Lys Ala Leu Ser Thr Cys Val Ser 225 230 235 240

Page 695

His Ile Thr Val Val 245 Val Leu 069269_0225_SL.TXT Phe Phe Val Pro Cys Ile 250 Phe Val 255 Tyr Met Arg Pro Ala Ala Thr Leu Ser Ile Asn Lys Ala Val Ala Val Phe 260 265 270 Tyr Thr Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Gln Met Lys Asn Ala Ile Arg Lys Leu Cys Ser Lys Lys Ala 290 295 300

Ile Ser Gly Asp Lys 305 <210> 623 <211> 930 <212> DNA <213> Canis familiaris <400> 623

atggaaaata aaagaaatgt gactgaattt attttaatag gtcttacaca gaaccccaca 60 atgcagaata tagtatttct gggatttttg attctgtaca tggtaacact ctcaggcaac 120 ttgctcattg tggttaccat taccaccagc caggctctga actcccccat gtacttcttt 180 ctgactcatc tttccgtgat agacacaatt tattcttcct cttcagctcc taagctgatt 240 gtggactccc ttcatgaaaa gaaaattatc tcctttagtg gctgtatggc tcaagtctat 300 gcagaacaca tttttggtgc tacagagatc atcttgctga cagtgatggc ctatgatcgc 360 tatgtggcca tctgcaaacc tcttcactat actactgtca tgaaccatag gttgtgcatt 420 ctcctgctgg gcgtggcctg gactggagga tttctccatg caaccattca gatcctcttc 480 acagtctggc tgcccttctg tggccctaat gtcatagatc atttcatgtg tgacttgtac 540 cctttgttga aacttgtttg catggacact catacccttg gtctctttgt tgctgtcaac 600 agtggtttca tctgcctttt aaacttcctc ctattggtgg tgtcctatgt ggtcatcctg 660 tactccctaa agaactatag cttggagggg aggcgcaaag cactttccac ctgtgtctct 720 cacattacag tggttgtctt gttctttgtg ccctgcatat ttgtgtatct gcgtccagtg 780

Page 696

069269_0225_SL.TXT accactctgc ccattgataa agctgttgct gtcttttaca ctatggtggt ccctatgtta aatcccttaa tctacaccct cagaaatgtt gaggtaaaaa atgctatgag gaagctctgg agaaaaaaag tgacttcaga taatgaataa

840

900

930 <210> 624 <211> 309 <212> PRT <213> Canis familiaris <400> 624

Met Glu 1 Asn Lys Arg Asn Val Thr Glu Phe Ile Leu Ile Gly Leu Thr 5 10 15 Gln Asn Pro Thr Met Gln Asn Ile Val Phe Leu Gly Phe Leu Ile Leu 20 25 30 Tyr Met Val Thr Leu Ser Gly Asn Leu Leu Ile Val Val Thr Ile Thr 35 40 45 Thr Ser Gln Ala Leu Asn Ser Pro Met Tyr Phe Phe Leu Thr His Leu 50 55 60 Ser Val Ile Asp Thr Ile Tyr Ser Ser Ser Ser Ala Pro Lys Leu Ile 65 70 75 80 Val Asp Ser Leu His Glu Lys Lys Ile Ile Ser Phe Ser Gly Cys Met 85 90 95 Ala Gln Val Tyr Ala Glu His Ile Phe Gly Ala Thr Glu Ile Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Val Met Asn His Arg Leu Cys Ile Leu Leu Leu Gly 130 135 140 Val Ala Trp Thr Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe 145 150 155 160

Page 697

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Thr Val Trp Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met 165 170 175 Cys Asp Leu Tyr Pro 180 Leu Leu Lys Leu Val 185 Cys Met Asp Thr His Thr 190 Leu Gly Leu Phe Val 195 Ala Val Asn 200 Ser Gly Phe Ile Cys Leu Leu Asn 205 Phe Leu 210 Leu Leu Val Val Ser 215 Tyr Val Val Ile Leu Tyr Ser Leu Lys 220 Asn Tyr 225 Ser Leu Glu Gly Arg 230 Arg Lys Ala Leu Ser Thr Cys Val Ser 235 240 His Ile Thr Val Val 245 Val Leu Phe Phe Val 250 Pro Cys Ile Phe Val Tyr 255 Leu Arg Pro Val Thr 260 Thr Leu Pro Ile Asp 265 Lys Ala Val Ala Val Phe 270 Tyr Thr Met Val Val 275 Pro Met Leu 280 Asn Pro Leu Ile Tyr Thr Leu Arg 285 Asn Val Glu Val Lys Asn Ala 290 295 Thr Ser Asp Asn Glu 305 <210> 625 <211> 1014 <212> DNA <213> Canis familiaris <400> 625 Met Arg Lys Leu Trp Arg Lys Lys Val 300 atgtgcctgc aacaattgca atccctgtgc tgtttgcaga taaatcaatt atccagatgc caaagtgggt tcacagaaca aatgaacaac gtgacggaat tcatcctgct tggcctgacg

120 cagaacccag atgtgcagaa actcttgttt gctgtgttta tagtcatcta ctttctcact Page 698

180

069269_0225_SL.TXT

gtggcaggca acttactcat tgtcgtgaca atcagcacca gcagagccct gggctccccc 240 atgtattttt ttctgtcttt cctgtccttc atagatagct gctgctcttc aactatggct 300 cccaaaatga tatttgactt acttgctaaa aagaaaacta tctccttcag tgggtgcatg 360 actcagctct ttgcagaaca tttctttggg ggagttgaga ttatcctgct cacagtgatg 420 gcctatgacc gctacgtggc tatctgcaag cccctacact acatgatcac aatgaacagg 480 caaatgtgtg ccaacttggt ggccgtggcc tgggctgggg gatttcttca tgctctgatt 540 caaattcttt ttatagtctg gttgcccttc tgcggcccca atgtcattga ccatttcatc 600 tgtgatcttt ttcctctgct aaaactctcc tgcactgata ctcacatctt tggacttttt 660 gtcgccgcca acagtgggct gatgtgtctg ctcatttttt ctattcttgt cacctcctat 720 gtcctcatcc tttactctct aagaactcac agtactaaag gacagcgtaa ggctctctct 780 acctgtgcct cccatgttac agtagttgtc ctattctttg taccctgtat attcgtgtac 840 cttaggccca tggtcacctt ccccatcgac aaagcagtgg ctgtgtttta tactatgata 900 acacccatgt taaatccttt aatctatacc ctcagaaact cagaagtgaa aaatgccatg 960 aggaagctct ggagccacaa agtaatcttg ggtaataaca attcatgtga ctag 1014

<210> 626 <211> 337 <212> PRT <213> Canis familiaris <400> 626

Met 1 Cys Leu Gln Gln Leu Gln Ser Leu Cys Cys Leu Gln Ile Asn 15 Gln 5 10 Leu Ser Arg Cys Gln Ser Gly Phe Thr Glu Gln Met Asn Asn Val Thr 20 25 30 Glu Phe Ile Leu Leu Gly Leu Thr Gln Asn Pro Asp Val Gln Lys Leu 35 40 45 Leu Phe Ala Val Phe Ile Val Ile Tyr Phe Leu Thr Val Ala Gly Asn 50 55 60

Page 699

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Leu 65 Leu Ile Val Val Thr Ile Ser Thr Ser Arg Ala Leu Gly Ser Pro 70 75 80 Met Tyr Phe Phe Leu Ser Phe Leu Ser Phe Ile Asp Ser Cys Cys Ser 85 90 95 Ser Thr Met Ala Pro Lys Met Ile Phe Asp Leu Leu Ala Lys Lys Lys 100 105 110 Thr Ile Ser Phe Ser Gly Cys Met Thr Gln Leu Phe Ala Glu His Phe 115 120 125 Phe Gly Gly Val Glu Ile Ile Leu Leu Thr Val Met Ala Tyr Asp Arg 130 135 140 Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Ile Thr Met Asn Arg 145 150 155 160 Gln Met Cys Ala Asn Leu Val Ala Val Ala Trp Ala Gly Gly Phe Leu 165 170 175 His Ala Leu Ile Gln Ile Leu Phe Ile Val Trp Leu Pro Phe Cys Gly 180 185 190 Pro Asn Val Ile Asp His Phe Ile Cys Asp Leu Phe Pro Leu Leu Lys 195 200 205 Leu Ser Cys Thr Asp Thr His Ile Phe Gly Leu Phe Val Ala Ala Asn 210 215 220 Ser Gly Leu Met Cys Leu Leu Ile Phe Ser Ile Leu Val Thr Ser Tyr 225 230 235 240 Val Leu Ile Leu Tyr Ser Leu Arg Thr His Ser Thr Lys Gly Gln Arg 245 250 255 Lys Ala Leu Ser Thr Cys Ala Ser His Val Thr Val Val Val Leu Phe 260 265 270

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Phe Val Pro Cys Ile Phe Val Tyr Leu Arg Pro Met Val Thr Phe Pro 275 280 285

Ile Asp Lys Ala Val Ala Val Phe Tyr Thr Met Ile Thr Pro Met Leu 290 295 300

Asn Pro Leu Ile Tyr Thr Leu Arg Asn Ser Glu Val Lys Asn Ala Met

305 310 315 320

Arg Lys Leu Trp Ser His Lys Val Ile Leu Gly Asn Asn Asn Ser Cys

325 330 335

Asp <210> 627 <211> 963 <212> DNA <213> Canis familiaris <400> 627

atggaccatg tgctcataac ccaagctgac tccatggaaa ggatgaacaa tgtaacagaa 60 tttgttctgc tgggcctgac ccagaatcca gaactgcaga aattcttatt tgctgtattt 120 ttaatcacct acttgatcac actggcaggt aacctactca tctcggtcac catcttcatc 180 agcccagctc tgggttctcc catgtacttt tttctatcct atttgtccat catagatggc 240 ttctactctt cttccatagc acctaaaatg atctttgact taatctctga gcggaacacc 300 atatccttca atggctgcat gactcaactc tttgctgaac atttctttgc tggtgctgag 360 atcattttat taattgccat ggcttatgac cgctatgtag ccatctgtaa gccattgcat 420 tacatgacca ttatgagccg acctgtctgt ggtttcttgg taggaatggc tggaattttg 480 ggctttgttc atggagggat ccaggttttg ttcatgatcc agttaccatt ctgtggcccc 540 aatgttattg accattttat gtgtgattta atacctctcc tggagctaac gtgtgcagac 600 actcacactt tggggcccct ggtttctgcc aacagtggat cactatgttt gctcactttt 660 tctatgctgg ttgcttctta cattgtcatc ctgcgctccc tgaggactca tagctctgaa 720 gggcgtcgca aagccctgtc tacctgtgct tctcatgtca ctgttgtcat cttattcttt 780

Page 701

069269_0225_SL.TXT gtaccttgtt cattcctgta cctgagaccc acgacctcct tccctgctga caaagctgtg actgtgtttt gtaccctagt aactcctatg ttgaatcctt taatctatac cctcagaaat tcagaagtaa aaaatgtcat gaagaaactc tggggacaaa taatgaaaac tggtgataaa tga

840

900

960

963 <210> 628 <211> 320 <212> PRT <213> Canis familiaris <400> 628

Met Asp His Val Leu Ile Thr Gln Ala Asp Ser Met Glu Arg Met Asn 1 5 10 15 Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr Gln Asn Pro Glu Leu 20 25 30 Gln Lys Phe Leu Phe Ala Val Phe Leu Ile Thr Tyr Leu Ile Thr Leu 35 40 45 Ala Gly Asn Leu Leu Ile Ser Val Thr Ile Phe Ile Ser Pro Ala Leu 50 55 60 Gly Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu Ser Ile Ile Asp Gly 65 70 75 80 Phe Tyr Ser Ser Ser Ile Ala Pro Lys Met Ile Phe Asp Leu Ile Ser 85 90 95 Glu Arg Asn Thr Ile Ser Phe Asn Gly Cys Met Thr Gln Leu Phe Ala 100 105 110 Glu His Phe Phe Ala Gly Ala Glu Ile Ile Leu Leu Ile Ala Met Ala 115 120 125 Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Ile 130 135 140 Met Ser Arg Pro Val Cys Gly Phe Leu Val Gly Met Ala Gly Ile Leu

Page 702

0 6926 9_02 25_S L.TX T 145 150 155 160 Gly Phe Val His Gly Gly Ile Gln Val Leu Phe Met Ile Gln Leu Pro 165 170 175 Phe Cys Gly Pro Asn Val Ile Asp His Phe Met Cys Asp Leu Ile Pro 180 185 190 Leu Leu Glu Leu Thr Cys Ala Asp Thr His Thr Leu Gly Pro Leu Val 195 200 205 Ser Ala Asn Ser Gly Ser Leu Cys Leu Leu Thr Phe Ser Met Leu Val 210 215 220 Ala Ser Tyr Ile Val Ile Leu Arg Ser Leu Arg Thr His Ser Ser Glu 225 230 235 240 Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser His Val Thr Val Val 245 250 255 Ile Leu Phe Phe Val Pro Cys Ser Phe Leu Tyr Leu Arg Pro Thr Thr 260 265 270 Ser Phe Pro Ala Asp Lys Ala Val Thr Val Phe Cys Thr Leu Val Thr 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Ser Glu Val Lys 290 295 300 Asn Val Met Lys Lys Leu Trp Gly Gln Ile Met Lys Thr Gly Asp Lys 305 310 315 320

<210> 629 <211> 909 <212> DNA <213> Canis familiaris <400> 629 atggaaatgc cacacaatat cacagaattt ttcatgctgg gactctcaca gaatgcagag atacagcggg tcctctttgt gttttttttg atcatctatg tggccacggt gtgtggcaac Page 703

120

069269_0225_SL.TXT atgctcactg tggtcactat cacctccagt cccatgctgg cttcccccat gtattatttc ctggccaact tgtcctttat tgacacctgt tattcgtcct ctatggctcc taaactcatt gctgactcct tgtgtgaggg gagagccatc tcttttgagg gctgcctggc tcagctcttt ggagcccatt ttctgggagg tgttgagatc attctgctca cggtcatggc ctatgaccgc tatgtggcca tctgcaagcc cctgcactac acgaccatca tgaccaggca tctctgtgcc ctgctggtgg gggtggcttg gttcggaggc ttcctgcatt ccctggtcca gctcctcctg gtccttcagc tgcccttctg tgggcctaat gtgatcaatc actttgtctg tgacttgtac cccttgctgg aagtcgcctg caccaacacg tatgtcatcg gcgtgctggt ggtcgccaac agtggtgtga tctgcctgtt gaacttcctc atgctggttg cttcctatgc tgtcatcctg cgttccttga ggtaccatgg tgcggaggcg agacgtaaag ccctgtccac ctgtggggct cacttcactg ttgttgccct gttctttgtg ccttgtatat ttatttatat gcggccatca tctactttgt ccatagacaa aatagtgtca gttttttatg gtattttgac acctatgttg aatccactca tttataccct aagaaatgaa gaggtaaaaa atgccatgag aaagctcttc actcagtaa <210> 630 <211> 302 <212> PRT <213> Canis familiaris <400> 630

180

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660

720

780

840

900

909

Met 1 Glu Met Pro His 5 Asn Ile Thr Glu Phe Phe Met 10 Leu Gly Leu 15 Ser Gln Asn Ala Glu Ile Gln Arg Val Leu Phe Val Phe Phe Leu Ile Ile 20 25 30 Tyr Val Ala Thr Val Cys Gly Asn Met Leu Thr Val Val Thr Ile Thr 35 40 45 Ser Ser Pro Met Leu Ala Ser Pro Met Tyr Tyr Phe Leu Ala Asn Leu 50 55 60

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Ser Phe 65 Ile Asp Thr Cys Tyr Ser Ser Ser Met Ala Pro Lys Leu Ile 80 70 75 Ala Asp Ser Leu Cys Glu Gly Arg Ala Ile Ser Phe Glu Gly Cys Leu 85 90 95 Ala Gln Leu Phe Gly Ala His Phe Leu Gly Gly Val Glu Ile Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Thr Arg His Leu Cys Ala Leu Leu Val Gly 130 135 140 Val Ala Trp Phe Gly Gly Phe Leu His Ser Leu Val Gln Leu Leu Leu 145 150 155 160 Val Leu Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asn His Phe Val 165 170 175 Cys Asp Leu Tyr Pro Leu Leu Glu Val Ala Cys Thr Asn Thr Tyr Val 180 185 190 Ile Gly Val Leu Val Val Ala Asn Ser Gly Val Ile Cys Leu Leu Asn 195 200 205 Phe Leu Met Leu Val Ala Ser Tyr Ala Val Ile Leu Arg Ser Leu Arg 210 215 220 Tyr His Gly Ala Glu Ala Arg Arg Lys Ala Leu Ser Thr Cys Gly Ala 225 230 235 240 His Phe Thr Val Val Ala Leu Phe Phe Val Pro Cys Ile Phe Ile Tyr 245 250 255 Met Arg Pro Ser Ser Thr Leu Ser Ile Asp Lys Ile Val Ser Val Phe 260 265 270

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Tyr Gly Ile Leu Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285

Asn Glu Glu Val Lys Asn Ala Met Arg Lys Leu Phe Thr Gln 290 295 300

<210> 631 <211> 768 <212> DNA <213> Canis familiaris <400> 631 gtgttctttt tgattgtcta ccttgtctct attggaggca acctacttat catgatcacc 60 attatcttta gtcccaccct gtgctcccct atgtactttt tcctctcatg cttgtcattc 120 actgatactt gctattcctt gtgtatgacc cccaaactca tcgctgactc cttgtatcag 180 gggagggcca tctcttttga gggctgccta gttcaattcc ttgttgccca tttattggga 240 ggaatggaaa tcattctgct cacggtcatg gcctatgacc gctatgtggc catctgcaag 300 cccctgcact acacgaccat catgaccagg catctctgtg ccctgctggt gggggtagct 360 tggttcggag gcttcctgca ttccctggtc cagctcctcc tggtccttca gctgcccttc 420 tgtgggccta atgtgatcaa tcactttgtc tgtgacttgt accccttgct ggaagtcgcc 480 tgcaccaaca cgtatgtcat cggcgtgctg gtggtcgcca acagtggtgt gatctgcctg 540 ttgaacttcc tcatgctggc tgcctcctgt gctgtcatcc tgcgttcctt gagttgccat 600 ggtgcggagg cgagtcataa agccctgtcc acctgtgggg cccacttcac tgttgttgcc 660 ctgttctttg tgccttgtat atttatttat atgcggcctt cgtctacttt gtccatagac 720 aaaatagtgg ctgtgcttat tgtattctga caaccatgtt caaccccc 768 <210> 632 <211> 249 <212> PRT <213> Canis familiaris <400> 632

Val Phe Phe Leu Ile Val Tyr Leu Val Ser Ile Gly Gly Asn Leu Leu 1 5 10 15 Ile Met Ile Thr Ile Ile Phe Ser Pro Thr Leu Cys Ser Pro Met Tyr

Page 706

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Phe Phe Leu Ser 35 Cys Leu Ser Phe Thr Asp Thr Cys Tyr Ser Leu Cys 40 45 Met Thr Pro Lys Leu Ile Ala Asp Ser Leu Tyr Gln Gly Arg Ala Ile 50 55 60 Ser Phe Glu Gly Cys Leu Val Gln Phe Leu Val Ala His Leu Leu Gly 65 70 75 80 Gly Met Glu Ile Ile Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val 85 90 95 Ala Ile Cys Lys Pro Leu His Tyr Thr Thr Ile Met Thr Arg His Leu 100 105 110 Cys Ala Leu Leu Val Gly Val Ala Trp Phe Gly Gly Phe Leu His Ser 115 120 125 Leu Val Gln Leu Leu Leu Val Leu Gln Leu Pro Phe Cys Gly Pro Asn 130 135 140 Val Ile Asn His Phe Val Cys Asp Leu Tyr Pro Leu Leu Glu Val Ala 145 150 155 160 Cys Thr Asn Thr Tyr Val Ile Gly Val Leu Val Val Ala Asn Ser Gly 165 170 175 Val Ile Cys Leu Leu Asn Phe Leu Met Leu Ala Ala Ser Cys Ala Val 180 185 190 Ile Leu Arg Ser Leu Ser Cys His Gly Ala Glu Ala Ser His Lys Ala 195 200 205 Leu Ser Thr Cys Gly Ala His Phe Thr Val Val Ala Leu Phe Phe Val 210 215 220 Pro Cys Ile Phe Ile Tyr Met Arg Pro Ser Ser Thr Leu Ser Ile Asp

Page 707

069269_0225_SL.TXT

225 230 235 240

Lys Ile Val Ala Val Leu Ile Val Phe 245 <210> 633 <211> 936 <212> DNA <213> Canis familiaris <400> 633

atggaaccaa ggagcaatgt aacttacttt gtcctcttgg gcctcacaca gaatccaaag 60 gaacagaagg tcctttttgt tatattcttg ctcttgtata ttttgactgt ggtgggcaac 120 ttgctcattg tggtgactgt aactgtcagt aagaccctga agtcacctat gtactttttt 180 cttgctagtt tatcatttat tcctcatcta tttatcattt attcctcatc tatttctccc 240 agattgattt cagacttgtt gtttggggaa aataccatat cctttcaatc ttgtatgact 300 cagctattaa cagagcactt ttttggtgga tcagaggtct ttcttctgct ggtgatggcc 360 tatgaccgct atgtggccat ctgtaagccc ttgcattatt tggttatcat gaggcaatgg 420 gtgtgtgttg tgctgcttgt ggtatcctgg gttggaggtt ttctgcattc agtaattcaa 480 cttagcacta tttatgggct cccattctgt gggcccaatg tcattgacca ttttttgtgt 540 gacatgtacc ctttattgaa actggtctgt actgacacat atgtcattgg gctgttagtt 600 gtagccaacg gaggagtgat ctgcactatt gtgtttgtgc tcttgctcat ctcttatggt 660 gtcatcttgc actctctaaa gaaccttagt ccagagggga agcggaaagc cctccagacc 720 tgtggctccc acatcactgt ggtggtcttc ttctttgttc catgtatttt catgtatgca 780 agacctgcta agaccttccc cattgacaaa tccctgagtg tgttttatac agtcataacc 840 cccatgctga acccactgat ctatactctg agaaattctg agatgacaaa tgccatgaag 900 cagctctggg gaagaaacat catatctctt agtaaa 936

<210> 634 <211> 312 <212> PRT <213> Canis familiaris <400> 634

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Met 1 Glu Pro Arg Ser 5 Asn Val Thr Tyr Phe Val Leu Leu Gly Leu Thr 10 15 Gln Asn Pro Lys Glu Gln Lys Val Leu Phe Val Ile Phe Leu Leu Leu 20 25 30 Tyr Ile Leu Thr Val Val Gly Asn Leu Leu Ile Val Val Thr Val Thr 35 40 45 Val Ser Lys Thr Leu Lys Ser Pro Met Tyr Phe Phe Leu Ala Ser Leu 50 55 60 Ser Phe Ile Pro His Leu Phe Ile Ile Tyr Ser Ser Ser Ile Ser Pro 65 70 75 80 Arg Leu Ile Ser Asp Leu Leu Phe Gly Glu Asn Thr Ile Ser Phe Gln 85 90 95 Ser Cys Met Thr Gln Leu Leu Thr Glu His Phe Phe Gly Gly Ser Glu 100 105 110 Val Phe Leu Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Lys Pro Leu His Tyr Leu Val Ile Met Arg Gln Trp Val Cys Val Val 130 135 140 Leu Leu Val Val Ser Trp Val Gly Gly Phe Leu His Ser Val Ile Gln 145 150 155 160 Leu Ser Thr Ile Tyr Gly Leu Pro Phe Cys Gly Pro Asn Val Ile Asp 165 170 175 His Phe Leu Cys Asp Met Tyr Pro Leu Leu Lys Leu Val Cys Thr Asp 180 185 190 Thr Tyr Val Ile Gly Leu Leu Val Val Ala Asn Gly Gly Val Ile Cys 195 200 205

Page 709

Thr Ile 210 Val Phe Val Leu Leu 215 069269_0225_SL.TXT Leu Ile Ser Tyr Gly Val 220 Ile Leu His Ser Leu Lys Asn Leu Ser Pro Glu Gly Lys Arg Lys Ala Leu Gln Thr 225 230 235 240 Cys Gly Ser His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile 245 250 255 Phe Met Tyr Ala Arg Pro Ala Lys Thr Phe Pro Ile Asp Lys Ser Leu 260 265 270 Ser Val Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Thr Leu Arg Asn Ser Glu Met Thr Asn Ala Met Lys Gln Leu Trp Gly 290 295 300 Arg Asn Ile Ile Ser Leu Ser Lys 305 310

<210> 635 <211> 687 <212> DNA <213> Canis familiaris <400> 635

agcttgggta ctgcttctat tttctgcctg tgtggctcaa cccttccaga tatctgttgc 60 tcttcatcca tgacccctga aatgctgctt ggcatttttg cagtaagaaa aaccatcttt 120 ttcaaaaagt gcatgactga agtctttgct gagcacctat gtggccatct gcaaagccct 180 gtagtatgaa atcatctcaa ggacagggat acagctttgt ctttcaggtg gcatgtgcta 240 gaggcttgtc cttgcaatca ctcaggtcct cttcacagtg tggctgcctg tgtgtggctc 300 caatatcata gaccatttgt gtgtgatata aatccttggt tgaaaaccat ctgcatggac 360 actcataccc ttggtctctt tgttgctgtc aaatgtgcat tcatctgcct atgaacattt 420 atgaacattt tcctcttgat ggtctcctag ctggtcatca tatgctcctt gagagcctgt 480 agcttggagg ggagacccaa agctatgtct gcctgtgttc tcatgtcact gtagtggctt 540

Page 710

069269_0225_SL.TXT agtattgtgt cctgaatgtt tatatatttg tatccaatca ccagcttctc cactgatcaa 600 gccaagaagc catggtaact ctgttgttaa acttaaacct atgtactcag aaatttggag 660 gtaaaaaatg ccatgaggaa gttttgg 687 <210> 636 <211> 62 <212> PRT <213> Canis familiaris <400> 636

Ser Leu Gly Thr Ala Ser Ile Phe Cys Leu Cys Gly Ser Thr Leu Pro 1 5 10 15 Asp Ile Cys Cys Ser Ser Ser Met Thr Pro Glu Met Leu Leu Gly Ile 20 25 30 Phe Ala Val Arg Lys Thr Ile Phe Phe Lys Lys Cys Met Thr Glu Val 35 40 45 Phe Ala Glu His Leu Cys Gly His Leu Gln Ser Pro Val Val 50 55 60

<210> 637 <211> 930 <212> DNA <213> Canis familiaris <400> 637

aaggaaatgg aaccaaagaa caatgttact gactttgtcc tcttgggcct cacacagaat 60 ccaaaggaac agaaggtcct ttttgttata ttcttgctct tctatatttt gaccatggtg 120 ggcaacctac tcattgtggt gactgtttct ttcagtaaga ccctgggctc acctatgtac 180 ttttttcttg ccagcttatc atttatggac gtcatttatt cctcttctat ttctcctgaa 240 ctgcttcaaa atttgttttt tgggggaaat atcatatcct tccaagtctg tatgatccag 300 ctgtttacag agcacttttg gtggatcaga gtctttcttc tgctggtgat ggcctatgac 360 cgctatgtgg ccatctgtaa gcccttgcat tatttggtta tcatgaggca atgggtgtgt 420 gttgtgctcc ttgtggtatc ctgggttgga ggttttctgc attcagtaat ccaacttagc 480 actatttatg ggctcccatt ctgtggcccc aatgtcatcg atcatttttt ctgtgatatg 540

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taccccttac tgaaactggt ctgtactgac acccatgtca ttggcatctt agttgctgcc 600 aacggaggga tgatctgctc tattgtgttt gtgctcttgc tcatctctta tggtgtcatc 660 ttgcactctc taaagaacct taatccggag gggaggcgga aagccctcca gacctgtggt 720 tcccacatca ctgtggtggt cttcttcttt gttccatgta ttttcatgta tgtaagacct 780 gctaagacct tccccattga caaatccctg agtgtgtttt atacagtcat aacccccatg 840 ctgaacccac tgatctacac tctgagaaat tctgagatga caaatgctat gaagaagctc 900 tggagcagaa gtatcatatc ttgcagcaaa 930 <210> 638 <211> 308 <212> PRT <213> Canis familiaris <400> 638 Met Glu Pro Lys Asn Asn Val Thr Asp Phe Val Leu Leu Gly Leu Thr 1 5 10 15 Gln Asn Pro Lys Glu Gln Lys Val Leu Phe Val Ile Phe Leu Leu Phe 20 25 30 Tyr Ile Leu Thr Met Val Gly Asn Leu Leu Ile Val Val Thr Val Ser 35 40 45 Phe Ser Lys Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Ser Leu 50 55 60 Ser Phe Met Asp Val Ile Tyr Ser Ser Ser Ile Ser Pro Glu Leu Leu 65 70 75 80 Gln Asn Leu Phe Phe Gly Gly Asn Ile Ile Ser Phe Gln Val Cys Met 85 90 95 Ile Gln Leu Phe Thr Glu His Phe Trp Trp Ile Arg Val Phe Leu Leu 100 105 110 Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His

115 120 125

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Tyr Leu 130 Val Ile Met Arg Gln Trp Val Cys Val Val Leu Leu Val Val 135 140 Ser Trp Val Gly Gly Phe Leu His Ser Val Ile Gln Leu Ser Thr Ile 145 150 155 160 Tyr Gly Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Phe Cys 165 170 175 Asp Met Tyr Pro Leu Leu Lys Leu Val Cys Thr Asp Thr His Val Ile 180 185 190 Gly Ile Leu Val Ala Ala Asn Gly Gly Met Ile Cys Ser Ile Val Phe 195 200 205 Val Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys Asn 210 215 220 Leu Asn Pro Glu Gly Arg Arg Lys Ala Leu Gln Thr Cys Gly Ser His 225 230 235 240 Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Met Tyr Val 245 250 255 Arg Pro Ala Lys Thr Phe Pro Ile Asp Lys Ser Leu Ser Val Phe Tyr 260 265 270 Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn 275 280 285 Ser Glu Met Thr Asn Ala Met Lys Lys Leu Trp Ser Arg Ser Ile Ile 290 295 300 Ser Cys Ser Lys

<210> 639 <211> 936

305

Page 713

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 639 atggataaag aaaaccactc agtggtgacg gagtttatct ttatgggcat cactcaggac 60 cgtcagctgc agatcatctt ctttgtgatt ttcctcctgg tctacctagt caatgtagtg 120 gggaacattg gtatgatcat cttgatcata gcagatactc agcttcacac acccatgtac 180 tttttcctct gcaacctctc ttttgttgac ctgggctact cctcagccat tgcccccagg 240 atgctggctg acttcttaac agagcacaaa gtcatctcct tctctagctg tgccacccag 300 tttgcgttct ttgtaggttt tgtagatgct gagtgctatg tcctggccgc catggcctat 360 gaccgtttcg tggccatctg ccgacccctc cactatggca ctctcatgtc caagcgagtc 420 tgcttggccc tcatgctggg ctcttacctg gccggcctgg tgagtttagt ggcccatact 480 tccctcacct tcagtttgag ctactgtggt tccaatatta tcaaccactt cttctgtgaa 540 atcccaccac tcttagccct ctcttgttca gatacctaca tcagtgagat cttgctgttt 600 agcctgtgtg gcttcattga attcagcacc attcttatca tcttcatctc ctatgctttc 660 atactcatcg caatcatcag aatgcgctca gcagaaggcc gccttaaggc tttctccacc 720 tgtgggtctc acctcactgg cgtcaccctt ttttatggca cagtcatgtt tatgtacctg 780 aggccaacat ccagctactc cctggaccaa gacaagtggg cctctgtgtt ctacactatt 840 atcatcccca tgctgaatcc cttgatctac agtttacgga acaaggatgt gaaagctgct 900 ttcaaaaaac taattggaaa aaaacctcaa gaataa 936 <210> 640 <211> 311 <212> PRT <213> Canis familiaris <400> 640

Met Asp Lys Glu Asn His Ser Val Val Thr Glu Phe Ile Phe Met Gly 1 5 10 15 Ile Thr Gln Asp Arg Gln Leu Gln Ile Ile Phe Phe Val Ile Phe Leu 20 25 30 Leu Val Tyr Leu Val Asn Val Val Gly Asn Ile Gly Met Ile Ile Leu

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Ile Ile Ala Asp Thr Gln Leu His Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60 Asn Leu Ser Phe Val Asp Leu Gly Tyr Ser Ser Ala Ile Ala Pro Arg 65 70 75 80 Met Leu Ala Asp Phe Leu Thr Glu His Lys Val Ile Ser Phe Ser Ser 85 90 95 Cys Ala Thr Gln Phe Ala Phe Phe Val Gly Phe Val Asp Ala Glu Cys 100 105 110 Tyr Val Leu Ala Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Gly Thr Leu Met Ser Lys Arg Val Cys Leu Ala Leu 130 135 140 Met Leu Gly Ser Tyr Leu Ala Gly Leu Val Ser Leu Val Ala His Thr 145 150 155 160 Ser Leu Thr Phe Ser Leu Ser Tyr Cys Gly Ser Asn Ile Ile Asn His 165 170 175 Phe Phe Cys Glu Ile Pro Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 Tyr Ile Ser Glu Ile Leu Leu Phe Ser Leu Cys Gly Phe Ile Glu Phe 195 200 205 Ser Thr Ile Leu Ile Ile Phe Ile Ser Tyr Ala Phe Ile Leu Ile Ala 210 215 220 Ile Ile Arg Met Arg Ser Ala Glu Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Gly Val Thr Leu Phe Tyr Gly Thr Val Met

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245 250 255

Phe Met Tyr Leu Arg Pro Thr Ser Ser 265 Tyr Ser Leu Asp Gln 270 Asp Lys 260 Trp Ala Ser Val Phe Tyr Thr Ile Ile Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala Phe Lys Lys Leu 290 295 300 Ile Gly Lys Lys Pro Gln Glu 305 310

<210> 641 <211> 933 <212> DNA <213> Canis familiaris <400> 641 atgtcacttg tcacctggat ggatttgatg gagaagatga ataatgtgac ggaattcatc ctcctgggct tgactcaaaa tgtggaactt cagaaatttt catttgttgt gtttttaatt gtctacttgg tcaccttggc aggcaacttg cttatcatga tcaccatcag caccagcaag gccctggaaa cccccatgta cttcttcctg tcttacttgt cccttataga tggctgctgt tcttcctcca tgacccctaa aatgcttgct gacactctta ctatgagaaa aataatctct tttaggggat gtatgactca ggtctttgct gagcattttt ttggtgctgc tgagataatc ctccttacag taatggccta tgaccgctat gtggccatct gcaaaccctt gcgctacaca accatcatga gtcaacaggt ctgtagcctc cttgtgggcg tggtctgggc tggagccttt gtccatgcaa ccattcagat cttcttcaca gtctggctgc ctttctgtgg gcccaatgtt atagatcatt tcatgtgtga cttaaaccct ttgttgaaac ttgtctgcat ggacactcat acccttggtc tctttgttgc tgccaatagt gggttcatct gtttgttaaa ctttctcctt ttggtggtct cctacatggt cattttgcac tctctaagga cctacagctt ggaggggaga cgtaaagccc tctctacctg tgtctctcac atcaccgtgg tcattttatt ctttgtgccc tgtatatttg tgtatttgcg tccagcgatc accttttcca ttgataaagc tgtggctgtg Page 716

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069269_0225_SL.TXT ttttacacca tgataactcc tatgttaaac cctttaatct acaccttgag aaatgcagag gtgaaaaatg ctataaagaa gctctggatc taa

900

933 <210> 642 <211> 310 <212> PRT <213> Canis familiaris <400> 642

Met Ser 1 Leu Val Thr Trp Met Asp Leu Met Glu Lys Met Asn Asn Val 5 10 15 Thr Glu Phe Ile Leu Leu Gly Leu Thr Gln Asn Val Glu Leu Gln Lys 20 25 30 Phe Ser Phe Val Val Phe Leu Ile Val Tyr Leu Val Thr Leu Ala Gly 35 40 45 Asn Leu Leu Ile Met Ile Thr Ile Ser Thr Ser Lys Ala Leu Glu Thr 50 55 60 Pro Met Tyr Phe Phe Leu Ser Tyr Leu Ser Leu Ile Asp Gly Cys Cys 65 70 75 80 Ser Ser Ser Met Thr Pro Lys Met Leu Ala Asp Thr Leu Thr Met Arg 85 90 95 Lys Ile Ile Ser Phe Arg Gly Cys Met Thr Gln Val Phe Ala Glu His 100 105 110 Phe Phe Gly Ala Ala Glu Ile Ile Leu Leu Thr Val Met Ala Tyr Asp 115 120 125 Arg Tyr Val Ala Ile Cys Lys Pro Leu Arg Tyr Thr Thr Ile Met Ser 130 135 140 Gln Gln Val Cys Ser Leu Leu Val Gly Val Val Trp Ala Gly Ala Phe 145 150 155 160

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Val His Ala Thr Ile Gln Ile Phe Phe Thr Val Trp Leu Pro Phe 175 Cys 165 170 Gly Pro Asn Val Ile Asp His Phe Met Cys Asp Leu Asn Pro Leu Leu 180 185 190 Lys Leu Val Cys Met Asp Thr His Thr Leu Gly Leu Phe Val Ala Ala 195 200 205 Asn Ser Gly Phe Ile Cys Leu Leu Asn Phe Leu Leu Leu Val Val Ser 210 215 220 Tyr Met Val Ile Leu His Ser Leu Arg Thr Tyr Ser Leu Glu Gly Arg 225 230 235 240

Arg Lys Ala Leu Ser Thr Cys Val Ser His Ile Thr Val Val Ile Leu 245 250 255

Phe Phe Val Pro Cys Ile Phe Val Tyr Leu Arg Pro Ala Ile Thr Phe 260 265 270

Ser Ile Asp Lys Ala Val Ala Val Phe Tyr Thr Met Ile Thr Pro Met 275 280 285

Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Ala Glu Val Lys Asn Ala

290 295 300 Ile Lys Lys Leu Trp Ile 305 310

<210> 643 <211> 930 <212> DNA <213> Canis familiaris

<400> 643 atggagatta ggaacaatgt gacagagttt gttctactgg ggcttacaga gaatccaaag 60 atgcagaaaa ttgtatttgt tgtgtttttt gtcatctaca ccatcactgt ggtaggtaat 120 atgctcattg tgatcaccat cactgccagc ccattgttgg gatcccccat gtactttttc 180

Page 718

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ctggcctatc tctcctttat tgatgcctgc tactcctctg tcaatactcc caaactgatc 240 atagattcgc tccatgaaaa gaagactacc ctgtacaatg gatgcatgac ccaaatattt 300 ggggaacatt tttttggagg tgctgaaggc atcctgctta ctgtgatggc ctatgaccgt 360 tatgtggcta tctgcaagcc actgcactac acaaccatca tgaatcggcg agtgtgtggc 420 ctgttaatgg gagtggtgtg ggttggaggc tttcttcatg caactataca gatcctcttc 480 attttccaat tacccttttg tggtccaaat gtcatagatc attttatgtg tgatctgaat 540 cctttgctca atcttgcctg cactgatacc cacactttag ggctcttcgt tgctgccaac 600 agtggattca tctgtctgct aaacttcctc ctcttaatgg tctcctatgt ggtcattcta 660 cgctccctcc ggaatcacaa cttggaggca aagcgcaaag ccctctccac ctgtgtctcc 720 cacatcacag tggtcgtcct attctttgtg ccctgcatat ttgtgtacat gagacccgca 780 gctacattat ccattgataa agcagttgca gtgttctaca ctattataac tcccatgtta 840 aaccccttaa tctatacctt gagaaatgcc caaatgaaaa atgctattag gaaattgtgt 900 agtaagaaag ctatttcagg tgacaaataa 930

<210> 644 <211> 309 <212> PRT <213> Canis familiaris <400> 644

Met Glu Ile Arg Asn Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr 1 5 10 15 Glu Asn Pro Lys Met Gln Lys Ile Val Phe Val Val Phe Phe Val Ile 20 25 30 Tyr Thr Ile Thr Val Val Gly Asn Met Leu Ile Val Ile Thr Ile Thr 35 40 45 Ala Ser Pro Leu Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu 50 55 60 Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Asn Thr Pro Lys Leu Ile 65 70 75 80

Page 719

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Ile Asp Ser Leu His 85 Glu Lys Lys Thr Thr Leu Tyr Asn Gly Cys Met 90 95 Thr Gln Ile Phe Gly Glu His Phe Phe Gly Gly Ala Glu Gly Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Asn Arg Arg Val Cys Gly Leu Leu Met Gly 130 135 140 Val Val Trp Val Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe 145 150 155 160 Ile Phe Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met 165 170 175 Cys Asp Leu Asn Pro Leu Leu Asn Leu Ala Cys Thr Asp Thr His Thr 180 185 190 Leu Gly Leu Phe Val Ala Ala Asn Ser Gly Phe Ile Cys Leu Leu Asn 195 200 205 Phe Leu Leu Leu Met Val Ser Tyr Val Val Ile Leu Arg Ser Leu Arg 210 215 220 Asn His Asn Leu Glu Ala Lys Arg Lys Ala Leu Ser Thr Cys Val Ser 225 230 235 240 His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Val Tyr 245 250 255 Met Arg Pro Ala Ala Thr Leu Ser Ile Asp Lys Ala Val Ala Val Phe 260 265 270 Tyr Thr Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285

Page 720

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Asn Ala Gln Met Lys Asn Ala Ile Arg Lys Leu Cys Ser Lys Lys Ala 290 295 300

Ile Ser Gly Asp Lys 305 <210> 645 <211> 930 <212> DNA <213> Canis familiaris <400> 645

atggagaata aaagaaatgt gactgaattt attttaatag gtcttacaca gaaccccaca 60 atgcagaata tagtatttct gggatttttg attctgtaca tggtaacact ctcaggcaac 120 ctgctcattg tggttaccat taccaccagc caggttctga actcccccat gtacttcttt 180 ctgactcatc tttccgtgat agacacaatt tattcttcct cttcagctcc taagctgatt 240 gtggactccc ttcatgaaaa gaaagttatc tcctttaatg ggtgtatggc tcaagtctat 300 gcagaacaca tttttggtgc tacggagatc atcctgctga tagtgatggc ctatgatcgc 360 tatgtggcca tctgcaaacc tcttcactat actactgtca tgaaccatag gctgtgcatt 420 ctcctgctgg gcatggcctg gactggagga tttctccatg caaccattca gatcctcttc 480 acagtctggc tgcccttctg tggacccaat gtcatagatc atttcatgtg tgatttgtac 540 cctttgttga aacttgtctg catggacact catacccttg gtctctttgt tgctctcaac 600 agtggtttca tctgcctttt aaacttcctc ctattggtgg tgtcctatgt ggtcatcctg 660 tactccctaa agaactatag cttggagggg aggcgcaaag cactttccac ctgtgtctct 720 cacattacag tggttgtttt ctcctttgtg ccttgcatat ttgtgtatct gcgcccagtg 780 accactttgc ccattgataa agctgttgct gtcttttaca ctatggtggt cccaatgtta 840 aatcccttaa tctacaccct cagaaatgct gaggtaaaaa atgctatgag gaagctctgg 900 agaaaaaacg tgacttcaga taatgaataa 930

<210> 646 <211> 309 <212> PRT <213> Canis familiaris

Page 721

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<400> 646 Ile Leu Ile Gly Leu Thr 15 Met 1 Glu Asn Lys Arg Asn 5 Val Thr Glu Phe 10 Gln Asn Pro Thr Met Gln Asn Ile Val Phe Leu Gly Phe Leu Ile Leu 20 25 30 Tyr Met Val Thr Leu Ser Gly Asn Leu Leu Ile Val Val Thr Ile Thr 35 40 45 Thr Ser Gln Val Leu Asn Ser Pro Met Tyr Phe Phe Leu Thr His Leu 50 55 60 Ser Val Ile Asp Thr Ile Tyr Ser Ser Ser Ser Ala Pro Lys Leu Ile 65 70 75 80 Val Asp Ser Leu His Glu Lys Lys Val Ile Ser Phe Asn Gly Cys Met 85 90 95 Ala Gln Val Tyr Ala Glu His Ile Phe Gly Ala Thr Glu Ile Ile Leu 100 105 110 Leu Ile Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Val Met Asn His Arg Leu Cys Ile Leu Leu Leu Gly 130 135 140 Met Ala Trp Thr Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe 145 150 155 160 Thr Val Trp Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met 165 170 175 Cys Asp Leu Tyr Pro Leu Leu Lys Leu Val Cys Met Asp Thr His Thr 180 185 190 Leu Gly Leu Phe Val Ala Leu Asn Ser Gly Phe Ile Cys Leu Leu Asn 195 200 205

Page 722

069269_0225_SL.TXT

Phe Leu Leu Leu Val Val Ser Tyr Val Val Ile Leu Tyr Ser Leu Lys 210 215 220 Asn Tyr Ser Leu Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Val Ser 225 230 235 240 His Ile Thr Val Val Val Phe Ser Phe Val Pro Cys Ile Phe Val Tyr 245 250 255 Leu Arg Pro Val Thr Thr Leu Pro Ile Asp Lys Ala Val Ala Val Phe 260 265 270 Tyr Thr Met Val Val Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp Arg Lys Asn Val 290 295 300 Thr Ser Asp Asn Glu

305 <210> 647 <211> 963 <212> DNA <213> Canis familiaris <400> 647

atggaccatg tgctcataac ccaagctgac tccatggaaa ggatgaacaa tgtaacagaa 60 tttgttctgc tgggcctgac ccagaatcca gaactgcaga aattcttatt tgctgtgttt 120 ttaatcacct acttgatcac actggcaggt aacctgctca tctcagtcac catcttcatc 180 agcccagctc tgggttctcc catgtacttt tttctgtcct acttgtccat tatagatggt 240 ttatactcct cttccatagc acctaaaatg atctttgact taatctctga gcagaacacc 300 atatccttca atggctgcat gactcaactc tttgctgaac atttctttgc tggagctgag 360 atcatcttat taattgccat ggcttatgac cgctatgtag ccatctgtaa gccattgcat 420 tacatgacca ttatgagcag acctgtctgt ggattcttgg taggaatggc tggaattttg 480

Page 723

069269_0225_SL.TXT

ggctttgttc atggagggat ccaggttttg ttcatgatcc agttaccatt ctgtggcccc 540 aatgtcatcg accatttttt gtgtgattta atacctctcc tggagctagc gtgtgcagac 600 actcacactt tggggcccct ggtttctgcc aacagtggat cactatgttt gctcactttt 660 tctatgctgg ttgcttctta cattgtcatc ctgcgctccc tgaggactca tagctctgaa 720 gggcgtcgca aagccctgtc tacctgtgct tctcatgtca ctgttgtcat cttattcttt 780 gtaccttgtt cattcctgta cctgagaccc acgacctcct tccctgctga caaagctgtg 840 actgtgtttt gtaccctagt aactcctatg ttgaatcctt taatctatac cctcagaaat 900 tcagaagtaa aaaatgtcat gaagaaactc tggggacaaa taatgaaaac tggtgataaa 960

tga 963 <210> 648 <211> 320 <212> PRT <213> Canis familiaris <400> 648

Met Asp His Val Leu Ile Thr Gln Ala Asp Ser Met Glu Arg Met Asn 1 5 10 15 Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr Gln Asn Pro Glu Leu 20 25 30 Gln Lys Phe Leu Phe Ala Val Phe Leu Ile Thr Tyr Leu Ile Thr Leu 35 40 45 Ala Gly Asn Leu Leu Ile Ser Val Thr Ile Phe Ile Ser Pro Ala Leu 50 55 60 Gly Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu Ser Ile Ile Asp Gly 65 70 75 80 Leu Tyr Ser Ser Ser Ile Ala Pro Lys Met Ile Phe Asp Leu Ile Ser 85 90 95 Glu Gln Asn Thr Ile Ser Phe Asn Gly Cys Met Thr Gln Leu Phe Ala 100 105 110

Page 724

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Glu His Phe 115 Phe Ala Gly Ala Glu Ile Ile Leu Leu Ile Ala Met Ala 120 125 Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Ile 130 135 140 Met Ser Arg Pro Val Cys Gly Phe Leu Val Gly Met Ala Gly Ile Leu 145 150 155 160 Gly Phe Val His Gly Gly Ile Gln Val Leu Phe Met Ile Gln Leu Pro 165 170 175 Phe Cys Gly Pro Asn Val Ile Asp His Phe Leu Cys Asp Leu Ile Pro 180 185 190 Leu Leu Glu Leu Ala Cys Ala Asp Thr His Thr Leu Gly Pro Leu Val 195 200 205 Ser Ala Asn Ser Gly Ser Leu Cys Leu Leu Thr Phe Ser Met Leu Val 210 215 220 Ala Ser Tyr Ile Val Ile Leu Arg Ser Leu Arg Thr His Ser Ser Glu 225 230 235 240 Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser His Val Thr Val Val 245 250 255 Ile Leu Phe Phe Val Pro Cys Ser Phe Leu Tyr Leu Arg Pro Thr Thr 260 265 270 Ser Phe Pro Ala Asp Lys Ala Val Thr Val Phe Cys Thr Leu Val Thr 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Ser Glu Val Lys 290 295 300 Asn Val Met Lys Lys Leu Trp Gly Gln Ile Met Lys Thr Gly Asp Lys 305 310 315 320

Page 725

069269_0225_SL.TXT <210> 649 <211> 837 <212> DNA <213> Canis familiaris <400> 649

ctttgtgttt tttttttggt catctatgtg gccacggtgt gtggcaacat gctcactgtg 60 gtcactatca cctccagtcc catgctggct tcccccatgt attatttcct ggccaacttg 120 tcctttattg acacctgtta ttcttcctct atggctccta aactcattgc tgacttcttg 180 tgtgagggga gagccatctc ttttgagggc tgcttggctc agctctttgg agcccatttt 240 ctgggaggtg ttgagatcat tctgctcatg gtcatggcct atgaccgcta tgtggccatc 300 tgcaagcccc tgcactacac gaccatcatg accaggcatc tctgtgccct gctggtgggg 360 gtggcttggt tgggaggctt cctgcattcc ttggtctagc tcctcctggt ccttcagctg 420 cccttctgtg ggcctaatgt gatcaatcac tttgtctgtg acttgtaccc cttgctggaa 480 gtcgcctgca ccaacacgta tgtcatcggc gtgctggtgg tcgccaacag tggtgtgatc 540 tgcctgttga acttcctcat gctggttgct tcctatgctg tcatcctgcg ttccttgagg 600 taccatggtg tggaggcgag acgtaaagct ctgtcaacct gtggggctct cttcactgtt 660 gttgccctgt tctttgtgcc ttgtatattt atttatatgc agccatcggc tactttgtcc 720 atagacaaaa tagtgtcagt ttttttttat ggtattttga cacctatgtt gaatccactc 780 atttatactc tgagaaatga agaggtaaaa gatgccataa gaaagctctt cactcag 837

<210> 650 <211> 202 <212> PRT <213> Canis familiaris <400> 650

Met Val Pro Gln Gly Thr Gln Asp Asp Ser Ile Gly Ser Asn Gln His 1 5 10 15 Glu Glu Val Gln Gln Ala Asp His Thr Thr Val Gly Asp His Gln His 20 25 30 Ala Asp Asp Ile Arg Val Gly Ala Gly Asp Phe Gln Gln Gly Val Gln

35 40 45

Page 726

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Val Thr 50 Asp Lys Val Ile Asp His Ile Arg Pro Thr Glu Gly Gln Leu 55 60 Lys Asp Gln Glu Glu Leu Asp Gln Gly Met Gln Glu Ala Ser Gln Pro 65 70 75 80 Ser His Pro His Gln Gln Gly Thr Glu Met Pro Gly His Asp Gly Arg 85 90 95 Val Val Gln Gly Leu Ala Asp Gly His Ile Ala Val Ile Gly His Asp 100 105 110 His Glu Gln Asn Asp Leu Asn Thr Ser Gln Lys Met Gly Ser Lys Glu 115 120 125 Leu Ser Gln Ala Ala Leu Lys Arg Asp Gly Ser Pro Leu Thr Gln Glu 130 135 140 Val Ser Asn Glu Phe Arg Ser His Arg Gly Arg Ile Thr Gly Val Asn 145 150 155 160 Lys Gly Gln Val Gly Gln Glu Ile Ile His Gly Gly Ser Gln His Gly 165 170 175 Thr Gly Gly Asp Ser Asp His Ser Glu His Val Ala Thr His Arg Gly 180 185 190 His Ile Asp Asp Gln Lys Lys Asn Thr Lys 195 200

<210> 651 <211> 909 <212> DNA <213> Canis familiaris <400> 651 atggatagtt cacgaaacat cacggaattt ttcatgctgg gactctcaca aaactccgaa gtgcagagag tattatttgt gttctttttg attgtctacc ttgtttctgt tggaggcaac

120

Page 727

069269 0225 SL.TXT ctacttatca tgatcaccat tatcttcagt ctctcatgct tgtcattcat tgatacttgc gctgactcct tgtatgaggg gagggccatc gttgcccatt tattgggagg aacggaaatc tacgtggcca tctgcaagcc cctgcactac ctgctggtgg gggtggcttg gttgggaggc gtccttcagc tgcccttctg tgggcctaat cccttgctgg aacttgcctg taccaacacg agtggtgtga tctgcctgtt gaacttcctc cgttccttga ggtgccatgg tgcggaggcg cacttcactg ttgttgccct gttctttgtg tctactttgt ccatagacaa aatagtggct aaccccctga tttatacatt gagaaatgca aaaaaatga <210> 652 <211> 302 <212> PRT <213> Canis familiaris cccaccctgg gctctcctat gtactttttc tattcctcgt gtatgacccc caaactcatc tcttttgagg gctgcctggt tcaattcttt attctgctca cggtcatggc ctatgaccgc acgaccatca tgaccaggca tctctgtgcc ttcctgcatt ccctggtcca gctcctcctg gtgatcaatc actttgtctg tgacttgtac tatgtcatcg gcgtgctggt ggtcgccaac atgctggttg cttcctatgc tgtcatcctg agacgtaaag ccctgtccac ctgtggggcc ccttgtatat ttatttatat gcagccatca gtgttttatt gtattttgac acccatgttc gaggtgaaaa atgccatgaa aaatctatgg

180

240

300

360

420

480

540

600

660

720

780

840

900

909 <400> 652

Met Asp Ser Ser Arg Asn Ile Thr 1 5 Gln Asn Ser Glu Val Gln Arg Val 20 Tyr Leu Val Ser Val Gly Gly Asn 35 40 Phe Ser Pro Thr Leu Gly Ser Pro 50 55 Ser Phe Ile Asp Thr Cys Tyr Ser

Glu Phe 10 Phe Met Leu Gly Leu 15 Ser Leu 25 Phe Val Phe Phe Leu 30 Ile Val Leu Leu Ile Met Ile 45 Thr Ile Ile Met Tyr Phe Phe 60 Leu Ser Cys Leu Ser Cys Met Thr Pro Lys Leu Ile

Page 728

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Ala Asp Ser Leu Tyr 85 Glu Gly Arg Ala Ile Ser Phe Glu Gly Cys Leu 90 95 Val Gln Phe Phe Val Ala His Leu Leu Gly Gly Thr Glu Ile Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Thr Arg His Leu Cys Ala Leu Leu Val Gly 130 135 140 Val Ala Trp Leu Gly Gly Phe Leu His Ser Leu Val Gln Leu Leu Leu 145 150 155 160 Val Leu Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asn His Phe Val 165 170 175 Cys Asp Leu Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asn Thr Tyr Val 180 185 190 Ile Gly Val Leu Val Val Ala Asn Ser Gly Val Ile Cys Leu Leu Asn 195 200 205 Phe Leu Met Leu Val Ala Ser Tyr Ala Val Ile Leu Arg Ser Leu Arg 210 215 220 Cys His Gly Ala Glu Ala Arg Arg Lys Ala Leu Ser Thr Cys Gly Ala 225 230 235 240 His Phe Thr Val Val Ala Leu Phe Phe Val Pro Cys Ile Phe Ile Tyr 245 250 255 Met Gln Pro Ser Ser Thr Leu Ser Ile Asp Lys Ile Val Ala Val Phe 260 265 270 Tyr Cys Ile Leu Thr Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg

Page 729

069269_0225_SL.TXT

275 280 285

Asn Ala Glu Val Lys Asn Ala Met Lys Asn Leu Trp Lys Lys 290 295 300 <210> 653 <211> 930 <212> DNA <213> Canis familiaris <400> 653

atgggaacca agaacaacgt gactgaattt gtgttgttcg gccttttcca gagcagggag 60 atgcagcttg tgtgctttgt ggtcttctcc ctcttccacg tgctcactgt cctgggaaac 120 cttctggtta tcatcaccat taatgccagc aagaccctga atgctcccat gtatttcttc 180 ctcagccacc tgtcttttgc ggacatgtgc tatccatctg ctaccacacc caagatgatt 240 gctgacactt tcgtggagcg aaagaccatc tccttcaatg ggtgcatgac ccagctcttt 300 tctgcccact tctttggtgg cactgagatc tttctcctca cagctatggc ctatgaccgc 360 tatgtggcca tctgtaggcc cctgcactac acggctatca tggatcggtg gaagtgtggt 420 ctgctggcag gggcctcttg ggtgggtggc ttcctgcatt ccatcctaca gaccctcctc 480 acagtccagc tgcccttttg tgggcctaat gagattgaca acttcttttg tgatgttcat 540 cccttgctga agctggcctg tgcagacact tatgtggtgg ggctcattgt ggtggccaac 600 agtggcatga tatctctcgt gtcctttatc atccttatca tctcctacgt ggtcatctta 660 ctgaacctga gaagccagtc atctgagggt cggcgcaagg ctctctctac atgtggctca 720 cacatcgtca ctgttctttt ggtccttctg ccccccatgt tcatgtacat tcgtccctcc 780 accaccctgg ctgttgacaa acttgtcatc ctctttaaca ttgtcatgcc acctttgctg 840 aaccctctca tctacacgtt gaggaataat gaggtgaaaa atgcaatgag gaaactgttt 900 agagtagagg ggaacatggg ggagaagtga 930

<210> 654 <211> 309 <212> PRT <213> Canis familiaris <400> 654

Page 730

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Met 1 Gly Thr Lys Asn 5 Asn Val Thr Glu Phe Val Leu Phe Gly Leu Phe 10 15 Gln Ser Arg Glu Met Gln Leu Val Cys Phe Val Val Phe Ser Leu Phe 20 25 30 His Val Leu Thr Val Leu Gly Asn Leu Leu Val Ile Ile Thr Ile Asn 35 40 45 Ala Ser Lys Thr Leu Asn Ala Pro Met Tyr Phe Phe Leu Ser His Leu 50 55 60 Ser Phe Ala Asp Met Cys Tyr Pro Ser Ala Thr Thr Pro Lys Met Ile 65 70 75 80 Ala Asp Thr Phe Val Glu Arg Lys Thr Ile Ser Phe Asn Gly Cys Met 85 90 95 Thr Gln Leu Phe Ser Ala His Phe Phe Gly Gly Thr Glu Ile Phe Leu 100 105 110 Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125 His Tyr Thr Ala Ile Met Asp Arg Trp Lys Cys Gly Leu Leu Ala Gly 130 135 140 Ala Ser Trp Val Gly Gly Phe Leu His Ser Ile Leu Gln Thr Leu Leu 145 150 155 160 Thr Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp Asn Phe Phe 165 170 175 Cys Asp Val His Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr Tyr Val 180 185 190 Val Gly Leu Ile Val Val Ala Asn Ser Gly Met Ile Ser Leu Val Ser 195 200 205

Page 731

Phe Ile 210 Ile Leu Ile Ile Ser 215 069269_0225_SL.TXT Tyr Val Val Ile Leu Leu 220 Asn Leu Arg Ser Gln Ser Ser Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Ile Val Thr Val Leu Leu Val Leu Leu Pro Pro Met Phe Met Tyr 245 250 255 Ile Arg Pro Ser Thr Thr Leu Ala Val Asp Lys Leu Val Ile Leu Phe 260 265 270 Asn Ile Val Met Pro Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg

275 280 285

Asn Asn Glu Val Lys Asn Ala Met Arg Lys Leu Phe Arg Val Glu Gly

290 295 300 Asn Met Gly Glu Lys 305 <210> 655 <211> 732 <212> DNA <213> Canis familiaris

<400> 655

atggcgactc caagcaatgt gactgaaatc attctcttgg ggtttccccc caacagggag 60 gtgcagaaga ccgtttctgt gctgtttctc ctcatgtaca tgaccattgt gctgggtaac 120 ggccttattt tggtgatggt gatggccagc aaagggctca cctcccccat gtatttcttc 180 ctcagcttcc tgtcctttgt ggagatttgt tactgctctg tcacagcccc caagctcatc 240 cttgactctt ttattgaaag gcaaaccatt tccctcaagg gctgcatcac acagatattt 300 ttcctccatt tctttggtgg tactgagatc tttctcctga cagtgatggc ctatgaccgc 360 tatgtggcca tctgcaagcc cctgcactac accgtcatca tgaaccggcg tgtgtgtggc 420 ctcttggtgg gtgcagcatg gagtgggggc ttgctgcatt ctgttgggca gacattcctc 480 attttccagc tgcccttctg tggcctcaag gtccttgacc actacttctg tgatgtccat 540

Page 732

069269_0225_SL.TXT cctgtattga agctggcctg ctcagacacc ttcctcattg gtgtgctgat catcgccaat ggtggctcca tttcagtggt cagcttcgtg gggctgcttg cttcctacgt ggtcatcctg tactccctga ggacacagac ctcagaaggt cggcgcaagg ctctgtccac ctgcgcctct cacattgcag tt

600

660

720

732 <210> 656 <211> 244 <212> PRT <213> Canis familiaris <400> 656

Met Ala Thr Pro Ser Asn Val Thr Glu Ile Ile Leu Leu Gly Phe Pro 1 5 10 15 Pro Asn Arg Glu Val Gln Lys Thr Val Ser Val Leu Phe Leu Leu Met 20 25 30 Tyr Met Thr Ile Val Leu Gly Asn Gly Leu Ile Leu Val Met Val Met 35 40 45 Ala Ser Lys Gly Leu Thr Ser Pro Met Tyr Phe Phe Leu Ser Phe Leu 50 55 60 Ser Phe Val Glu Ile Cys Tyr Cys Ser Val Thr Ala Pro Lys Leu Ile 65 70 75 80 Leu Asp Ser Phe Ile Glu Arg Gln Thr Ile Ser Leu Lys Gly Cys Ile 85 90 95 Thr Gln Ile Phe Phe Leu His Phe Phe Gly Gly Thr Glu Ile Phe Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Val Ile Met Asn Arg Arg Val Cys Gly Leu Leu Val Gly 130 135 140 Ala Ala Trp Ser Gly Gly Leu Leu His Ser Val Gly Gln Thr Phe Leu

Page 733

0 6926 9_02 25_S L.TX T 145 150 155 160 Ile Phe Gln Leu Pro Phe Cys Gly Leu Lys Val Leu Asp His Tyr Phe 165 170 175 Cys Asp Val His Pro Val Leu Lys Leu Ala Cys Ser Asp Thr Phe Leu 180 185 190 Ile Gly Val Leu Ile Ile Ala Asn Gly Gly Ser Ile Ser Val Val Ser 195 200 205 Phe Val Gly Leu Leu Ala Ser Tyr Val Val Ile Leu Tyr Ser Leu Arg 210 215 220 Thr Gln Thr Ser Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 His Ile Ala Val

<210> 657 <211> 930 <212> DNA <213> Canis familiaris <400> 657 atggcgaata caagtaacgt gactcagtta attatcattg gtcttttcca ggatccagag 60 gttcagagag tgtgttttgt ggtgtttatt ctcgtgtacc tggccacagt agttggcaat 120 ggcctcattg tcctgacagt caatgtcagt aagagtctgc attcccccat gtacttcttc 180 ctcagctacc tgtccctggt ggagatcacg tactcctcta ctgttgtccc taaattcatc 240 acagacttac ttgccaagat taaaaccatt tccctggagg gctgtgtagc tcagatattc 300 ttcttccact tctttggagt cactgagatc ttcctgctta cggtaatggc ctatgaccgc 360 tatgtggcca tctgcaaacc ccttcactac acaaccatca tgagccggtc tgtgtgtcgc 420 cttctggtgg ctggttcctg gcttgggggc ataattcact ctatggtcca gatccttgtt 480 gctgttcagc tgcccttctg tggtcccaat gtgattgacc actacttctg tgacctccat 540 cccttattca agcttgcctg cactgacact tctgtggagg gggttattgt gttggccaac 600

Page 734

069269_0225_SL.TXT

agtgggttaa tctctgtttt ctcctttctt atcttggtat cctcctatat tgtcatcttg 660 ttcaacttga ggaaccattc tgcagagggg aggcgcaaag ccctctccac ctgtgcctct 720 cacatcacgg tggtcctttt gttctttgga cctgccatct ttctctatat gcgaccctct 780 tccaccttca ctgaggacaa actggtggcc gtgttctaca cagtcgtcac tcccatgctg 840 aaccccatca tctacacact cagaaatgca gaggtcaaaa gtgccattag gaagctgtgg 900 cggaagaaag tgaactcagt agtggaataa 930

<210> 658 <211> 309 <212> PRT <213> Canis familiaris <400> 658

Met Ala Asn Thr Ser Asn Val Thr Gln Leu Ile Ile Ile Gly Leu Phe 1 5 10 15 Gln Asp Pro Glu Val Gln Arg Val Cys Phe Val Val Phe Ile Leu Val 20 25 30 Tyr Leu Ala Thr Val Val Gly Asn Gly Leu Ile Val Leu Thr Val Asn 35 40 45 Val Ser Lys Ser Leu His Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu 50 55 60 Ser Leu Val Glu Ile Thr Tyr Ser Ser Thr Val Val Pro Lys Phe Ile 65 70 75 80 Thr Asp Leu Leu Ala Lys Ile Lys Thr Ile Ser Leu Glu Gly Cys Val 85 90 95 Ala Gln Ile Phe Phe Phe His Phe Phe Gly Val Thr Glu Ile Phe Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125

Page 735

His Tyr 130 Thr Thr Ile Met Ser 135 069269_0225_SL.TXT Arg Ser Val Cys Arg Leu 140 Leu Val Ala Gly Ser Trp Leu Gly Gly Ile Ile His Ser Met Val Gln Ile Leu Val 145 150 155 160 Ala Val Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu His Pro Leu Phe Lys Leu Ala Cys Thr Asp Thr Ser Val 180 185 190 Glu Gly Val Ile Val Leu Ala Asn Ser Gly Leu Ile Ser Val Phe Ser 195 200 205 Phe Leu Ile Leu Val Ser Ser Tyr Ile Val Ile Leu Phe Asn Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 His Ile Thr Val Val Leu Leu Phe Phe Gly Pro Ala Ile Phe Leu Tyr 245 250 255 Met Arg Pro Ser Ser Thr Phe Thr Glu Asp Lys Leu Val Ala Val Phe 260 265 270 Tyr Thr Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Ser Ala Ile Arg Lys Leu Trp Arg Lys Lys Val 290 295 300 Asn Ser Val Val Glu

<210> 659 <211> 930 <212> DNA <213> Canis familiaris

305

Page 736

069269_0225_SL.TXT <400> 659

atgggaacca agaacaacgt gactgaattt gtgttgttcg gccttttcca gagcagggag 60 atgcagcttg tgtgctttgt ggtcttctcc ctcttccacg tgctcactgt cctggggaac 120 cttctggtca tcatcatcat caatgccagc aagaccctga attctcccat gtatttcttc 180 ctcagccacc tgtcttttgc ggacatgtgc tatccatctg ctaccacacc caagatgatt 240 gctaacagtt tcatggagcg aaagaccatc tccttcaatg gctgcatgac ccagctcttt 300 tctgcccact tctttggttg cactgagatc tttctcctca cagctatggc ctatgaccgc 360 tatgtggcca tctgtaggcc cctgcactac acggctatca tggatcggtg gaagtgtggt 420 ctgctggcag gggcctcctg ggtgggtggc tttctgcatt ccatcctaca gaccctcctc 480 acagtccagc tgcccttttg tgggcctaat gagattgaca acttcttctg tgatgttcat 540 cccttgctga agctggcctg tgctgacact tatttggtgg ggctcattgt gatggtcaac 600 agtagtatga tcactttggg gtcctttatc atccttatca tctcctacat ggtcatctta 660 ctgaacctga gaaaccagtc atctgagggc tggcgtaagg ctctctctac atgtggctca 720 cacatcatca ctgttctttt ggtccttctg ccccccatgt tcatgtatac tcgtccctcc 780 accaccctgg ctgctgacaa acttgtcatc ctctttaaca ttgtcatgcc acctttgctg 840 aaccctctga tctacacttt gaggaacaat gaggtgaaaa atgcaatgag gaaactgttt 900 agagtagagg ggagcatggg ggagaagtga 930

<210> 660 <211> 309 <212> PRT <213> Canis familiaris <400> 660

Met 1 Gly Thr Lys Asn Asn Val Thr Glu Phe Val Leu Phe Gly Leu Phe 5 10 15 Gln Ser Arg Glu Met Gln Leu Val Cys Phe Val Val Phe Ser Leu Phe 20 25 30 His Val Leu Thr Val Leu Gly Asn Leu Leu Val Ile Ile Ile Ile Asn 35 40 45

Page 737

069269_0225_SL.TXT

Ala Ser 50 Lys Thr Leu Asn Ser Pro 55 Met Tyr Phe Phe Leu Ser His 60 Leu Ser Phe Ala Asp Met Cys Tyr Pro Ser Ala Thr Thr Pro Lys Met Ile 65 70 75 80 Ala Asn Ser Phe Met Glu Arg Lys Thr Ile Ser Phe Asn Gly Cys Met 85 90 95 Thr Gln Leu Phe Ser Ala His Phe Phe Gly Cys Thr Glu Ile Phe Leu 100 105 110 Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125 His Tyr Thr Ala Ile Met Asp Arg Trp Lys Cys Gly Leu Leu Ala Gly 130 135 140 Ala Ser Trp Val Gly Gly Phe Leu His Ser Ile Leu Gln Thr Leu Leu 145 150 155 160 Thr Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp Asn Phe Phe 165 170 175 Cys Asp Val His Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr Tyr Leu 180 185 190 Val Gly Leu Ile Val Met Val Asn Ser Ser Met Ile Thr Leu Gly Ser 195 200 205 Phe Ile Ile Leu Ile Ile Ser Tyr Met Val Ile Leu Leu Asn Leu Arg 210 215 220 Asn Gln Ser Ser Glu Gly Trp Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Ile Ile Thr Val Leu Leu Val Leu Leu Pro Pro Met Phe Met Tyr 245 250 255

Page 738

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Thr Arg Pro Ser 260 Thr Thr Leu Ala Ala 265 Asp Lys Leu Val Ile 270 Leu Phe Asn Ile Val Met Pro Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Asn Glu Val Lys Asn Ala Met Arg Lys Leu Phe Arg Val Glu Gly 290 295 300

Ser Met Gly Glu Lys 305 <210> 661 <211> 954 <212> DNA <213> Canis familiaris <400> 661

atgatcagat acatgaaaga agtccaaggc agaaatcaaa cagaaatgac tgaatttatc 60 ctcttaggac tctcagacaa ctcagatcta caaattgtcc tctttggatt gtttctgttt 120 atttatatgg caaccatggt gggtaatttg gggatgattg tgttaattaa gattgacccc 180 tgtctccaca cccccatgta cttctttctc agtagcctgt cttttgttga tgcatcttac 240 tcttcttctg tcactcctaa gatgctggta aacctcatgg ccaagaataa agccatttct 300 tttaatggat gtgctgctcc gttctacttc tttggttcct tcttggggac tgaatgcttt 360 ctgttggcca cgatggcata tgaccgctat gcagccattt ggaaccctct gcgatactca 420 gttctcatgt ctgggaaaat ttgcttctta ctaatagcta cctctttctt agcaggcttt 480 gggaatgcag ccatacacac aggaatgact ttcagattgt ccttttgtgg ctctaatagg 540 atcaaccatt tctactgtga caccccaccc ctgctcaaac tctcttgctc tgacactcgc 600 atcaatggca ttgtgatcat ggctttctcc agctttaatg tcatcagttg tgttatgatt 660 gttctcattt cctacctgtg tatcctcatt gccatcttga gaatgccttc tttagaaagc 720 agacacaaag ccttctccac ctgtgcctcc cacctcatgg ctgtcaccat attctttggg 780 acaattctct tcatgtattt gcgccctaca tctagctatt caatggaaca ggacaagatt 840 gtctctgtct tttatacagt agtgatccct atgctaaatc ccctcatcta cagtttgaaa 900

Page 739

069269_0225_SL.TXT aataaggatg tgaaaggggc cttaaagaag attttacaga aacacctact gtaa

954 <210> 662 <211> 317 <212> PRT <213> Canis familiaris <400> 662

Met 1 Ile Arg Tyr Met 5 Lys Glu Val Gln Gly Arg Asn Gln Thr Glu Met 10 15 Thr Glu Phe Ile Leu Leu Gly Leu Ser Asp Asn Ser Asp Leu Gln Ile 20 25 30 Val Leu Phe Gly Leu Phe Leu Phe Ile Tyr Met Ala Thr Met Val Gly 35 40 45 Asn Leu Gly Met Ile Val Leu Ile Lys Ile Asp Pro Cys Leu His Thr 50 55 60 Pro Met Tyr Phe Phe Leu Ser Ser Leu Ser Phe Val Asp Ala Ser Tyr 65 70 75 80 Ser Ser Ser Val Thr Pro Lys Met Leu Val Asn Leu Met Ala Lys Asn 85 90 95 Lys Ala Ile Ser Phe Asn Gly Cys Ala Ala Pro Phe Tyr Phe Phe Gly 100 105 110 Ser Phe Leu Gly Thr Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp 115 120 125 Arg Tyr Ala Ala Ile Trp Asn Pro Leu Arg Tyr Ser Val Leu Met Ser 130 135 140 Gly Lys Ile Cys Phe Leu Leu Ile Ala Thr Ser Phe Leu Ala Gly Phe 145 150 155 160 Gly Asn Ala Ala Ile His Thr Gly Met Thr Phe Arg Leu Ser Phe Cys

165 170 175

Page 740

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Gly Ser Asn Arg Ile Asn His Phe Tyr Cys Asp Thr Pro Pro Leu Leu 180 185 190 Lys Leu Ser Cys Ser Asp Thr Arg Ile Asn Gly Ile Val Ile Met Ala 195 200 205 Phe Ser Ser Phe Asn Val Ile Ser Cys Val Met Ile Val Leu Ile Ser 210 215 220 Tyr Leu Cys Ile Leu Ile Ala Ile Leu Arg Met Pro Ser Leu Glu Ser 225 230 235 240 Arg His Lys Ala Phe Ser Thr Cys Ala Ser His Leu Met Ala Val Thr 245 250 255 Ile Phe Phe Gly Thr Ile Leu Phe Met Tyr Leu Arg Pro Thr Ser Ser 260 265 270 Tyr Ser Met Glu Gln Asp Lys Ile Val Ser Val Phe Tyr Thr Val Val 275 280 285 Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Lys Asn Lys Asp Val 290 295 300 Lys Gly Ala Leu Lys Lys Ile Leu Gln Lys His Leu Leu 305 310 315

<210> 663 <211> 930 <212> DNA <213> Canis <400> 663 atggcgactc gtgcagaaga ggccttattg ctcagcttcc familiaris caagcaatgt ctgtttctgt tggtgatggt tgtcctttgt gactgaaatc gctgtttctc gatggccagc ggagatctgt attctcttgg ctcatgtaca aaagggctca tactgctctg gattttcccc tggccattgt cctcccccat tcacagcccc caacagggag gctgggtaac gtatttcttc caagctcatc

120

180

240

Page 741

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cttgactctt ttattgaaag gcaaaccatt tccctcaagg gctgcatcac acagatattt 300 ttcctccatt tctttggtgg tactgagatc tttctcctga cagtgatggc ctatgaccgc 360 tatgtggcca tctgcaagcc cctgcactat accgtcatca tgaaccggcg tgtgtgtggc 420 ctcctggtgg gtgcagcatg gagtgggggc ttgctgcatt ctgttgggca gacattcctc 480 attttccagc tgcccttctg tggcctcaag gtccttgacc actacttctg tgatgtccat 540 cctgtattga agctggtctg ctcagacacc ttcctcattg gtgtgctgat catcgccaat 600 ggtggctcca tttcagtggt cagcttcatg gggctgcttg cttcctacgt ggtcatcctg 660 tactccctga ggacacagac ctcagaaggt cggcgcaagg ctctgtccac ctgtgcctct 720 cacattgcag ttgtgagtct gttcttcata ccctgttcct ttgtctacat gaggccctgt 780 gtcaccctcc ctgcagacaa gatagttgct gtgttttaca cagtggtcac acctctctta 840 aaccccatca tttactcctt caggaatgct gacatgaaaa atgccatgag aagactgatg 900 gggaggacag tgatctgggg aaatagatga 930

<210> 664 <211> 309 <212> PRT <213> Canis familiaris <400> 664

Met Ala Thr Pro Ser Asn Val Thr Glu Ile Ile Leu Leu Gly Phe Ser 1 5 10 15 Pro Asn Arg Glu Val Gln Lys Thr Val Ser Val Leu Phe Leu Leu Met 20 25 30 Tyr Met Ala Ile Val Leu Gly Asn Gly Leu Ile Val Val Met Val Met 35 40 45 Ala Ser Lys Gly Leu Thr Ser Pro Met Tyr Phe Phe Leu Ser Phe Leu 50 55 60 Ser Phe Val Glu Ile Cys Tyr Cys Ser Val Thr Ala Pro Lys Leu Ile 65 70 75 80 Leu Asp Ser Phe Ile Glu Arg Gln Thr Ile Ser Leu Lys Gly Cys Ile

Page 742

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85 90 95

Thr Gln Ile Phe Phe Leu His Phe Phe Gly Gly Thr Glu Ile Phe Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Val Ile Met Asn Arg Arg Val Cys Gly Leu Leu Val Gly 130 135 140 Ala Ala Trp Ser Gly Gly Leu Leu His Ser Val Gly Gln Thr Phe Leu 145 150 155 160 Ile Phe Gln Leu Pro Phe Cys Gly Leu Lys Val Leu Asp His Tyr Phe 165 170 175 Cys Asp Val His Pro Val Leu Lys Leu Val Cys Ser Asp Thr Phe Leu 180 185 190 Ile Gly Val Leu Ile Ile Ala Asn Gly Gly Ser Ile Ser Val Val Ser 195 200 205 Phe Met Gly Leu Leu Ala Ser Tyr Val Val Ile Leu Tyr Ser Leu Arg 210 215 220 Thr Gln Thr Ser Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 His Ile Ala Val Val Ser Leu Phe Phe Ile Pro Cys Ser Phe Val Tyr 245 250 255 Met Arg Pro Cys Val Thr Leu Pro Ala Asp Lys Ile Val Ala Val Phe 260 265 270 Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Ile Ile Tyr Ser Phe Arg 275 280 285 Asn Ala Asp Met Lys Asn Ala Met Arg Arg Leu Met Gly Arg Thr Val

Page 743

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290 295 300

Ile Trp Gly Asn Arg 305 <210> 665 <211> 930 <212> DNA <213> Canis familiaris <400> 665

atgggtaaca cacacaatgt gaccgaattc gtttttctgg gactttcttc caatcaggat 60 gtacagaaag ttttctttgt gctgtttctg tttttgtaca cagcagttgt gctggggaat 120 ctcctcattg tgctcattgt catgaccagc agaaggcttg gttcccccat gtacttcttc 180 ctcagctatc tatcctttgt ggagatctgc tactcctcta caacagcacc caaactcatc 240 tcggatttgc tggctgaaag gaaagcaatt tctttgtggg gctgcatgac acagcttttt 300 ttcatgcact tcttcggtgg cactgagatc ctcctgctca ctgtgatggc ctatgaccgc 360 tatgtggcca tctgtaggcc cctcaactat accgttatga tgaaccggca ggtatgcgct 420 gtcctggtgg gaatggcatg ggtgggaggc tttgtacatt cctttgccca aatccttttg 480 atcttccgct tgcccttctg cggtcccaat gtgattgacc actatttctg tgacctgctt 540 cctgtgctca aacttgcctg ctctgacacc ttcctcattg gtgtgctgat tgttgccaat 600 ggggggacct tgtctgtgat cagctttggg atcatcttag cctcctacgt ggtcattttg 660 ctccatttga ggactcgaag ctctgagggg cggagcaagg ccctctccac ctgtgggtcc 720 catatcactg tggttacctt attctttggg ccatgtatct tcatctatct gaggccttct 780 accaccttgt ctgcagacaa gacagtggct gtgttctaca cagtgatcac cccactcctc 840 aaccctgtca tttactccct aagaaatgct gaagtgaaga aggccatgaa gaagctgtgg 900 atcaggacga tgaagctaga agagaaatag 930

<210> 666 <211> 309 <212> PRT <213> Canis familiaris <400> 666

Page 744

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Met 1 Gly Asn Thr His 5 Asn Val Thr Glu Phe Val Phe Leu Gly Leu Ser 10 15 Ser Asn Gln Asp Val Gln Lys Val Phe Phe Val Leu Phe Leu Phe Leu 20 25 30 Tyr Thr Ala Val Val Leu Gly Asn Leu Leu Ile Val Leu Ile Val Met 35 40 45 Thr Ser Arg Arg Leu Gly Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu 50 55 60 Ser Phe Val Glu Ile Cys Tyr Ser Ser Thr Thr Ala Pro Lys Leu Ile 65 70 75 80 Ser Asp Leu Leu Ala Glu Arg Lys Ala Ile Ser Leu Trp Gly Cys Met 85 90 95 Thr Gln Leu Phe Phe Met His Phe Phe Gly Gly Thr Glu Ile Leu Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125 Asn Tyr Thr Val Met Met Asn Arg Gln Val Cys Ala Val Leu Val Gly 130 135 140 Met Ala Trp Val Gly Gly Phe Val His Ser Phe Ala Gln Ile Leu Leu 145 150 155 160 Ile Phe Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Leu Pro Val Leu Lys Leu Ala Cys Ser Asp Thr Phe Leu 180 185 190 Ile Gly Val Leu Ile Val Ala Asn Gly Gly Thr Leu Ser Val Ile Ser 195 200 205

Page 745

Phe Gly 210 Ile Ile Leu Ala Ser 215 069269_0225_SL.TXT Tyr Val Val Ile Leu Leu 220 His Leu Arg Thr Arg Ser Ser Glu Gly Arg Ser Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Ile Thr Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Leu Arg Pro Ser Thr Thr Leu Ser Ala Asp Lys Thr Val Ala Val Phe 260 265 270 Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Val Ile Tyr Ser Leu Arg 275 280 285 Asn Ala Glu Val Lys Lys Ala Met Lys Lys Leu Trp Ile Arg Thr Met 290 295 300 Lys Leu Glu Glu Lys

305

<210> 667 <211> 930 <212> DNA <213> Canis familiaris <400> 667 atggcgaata caaataacgt gactgagtta attatcattg gtcttttcca ggatccagag 60 gtgcagagag tgtgttttgt gatatttctt ctcgtgtacc tggccacggt ggtgggcaat 120 ggcctcattg tcctgacagt caatgtcagt aagagtttgc attcccccat gtactttttc 180 ctcagctacc tgtccctggt ggagatcacg tactcttcta ctgttgtccc taaattcatc 240 acagacttac ttgccaagat taaaaccatt tccctggagg gctgtgtagc tcagatattc 300 ttcttccact tctttggagt cactgagatc ttcctgctta cggtaatggc ctatgaccgc 360 tatgtggcca tctgcaaacc ccttcactac acaaccatca tgagccggtc tgtgtgttgc 420 cttctggtgg ctggttcctg gattggtggc ttttttcact ccatggttca gattattatt 480 acactccagt tgtctttctg tggtcccaat gtgattgacc actacttctg tgacctccat 540

Page 746

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cccttattca agcttgcctg cactgacact tctgtggagg gggttattgt gttggccaac 600 agtgggttat tttctatctt ttccttcctc ctcctagtgt cctcctatat tgtcatcctg 660 ttcaacttga ggaaccattc tgcagagggg aggcgcaaag ccctctccac ctgtgcctct 720 catatcatgg tggtcctttt gttctttgga cctgccatct ttctctacat gcgacctccg 780 tccaccttca ctgaggacaa actggtggcc gtgttctaca cggttgtcac tcccatgctg 840 aaccccatca tctacacact cagaaatgca gaggtgaaaa atgccatgag gaagctgtgg 900 gggaagaaag tgaactctgg gatgggataa 930

<210> 668 <211> 309 <212> PRT <213> Canis familiaris <400> 668

Met Ala Asn Thr Asn Asn Val Thr Glu Leu Ile Ile Ile Gly Leu Phe 1 5 10 15 Gln Asp Pro Glu Val Gln Arg Val Cys Phe Val Ile Phe Leu Leu Val 20 25 30 Tyr Leu Ala Thr Val Val Gly Asn Gly Leu Ile Val Leu Thr Val Asn 35 40 45 Val Ser Lys Ser Leu His Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu 50 55 60 Ser Leu Val Glu Ile Thr Tyr Ser Ser Thr Val Val Pro Lys Phe Ile 65 70 75 80 Thr Asp Leu Leu Ala Lys Ile Lys Thr Ile Ser Leu Glu Gly Cys Val 85 90 95 Ala Gln Ile Phe Phe Phe His Phe Phe Gly Val Thr Glu Ile Phe Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125

Page 747

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His Tyr 130 Thr Thr Ile Met Ser Arg Ser Val Cys Cys Leu Leu Val Ala 135 140 Gly Ser Trp Ile Gly Gly Phe Phe His Ser Met Val Gln Ile Ile Ile 145 150 155 160 Thr Leu Gln Leu Ser Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu His Pro Leu Phe Lys Leu Ala Cys Thr Asp Thr Ser Val 180 185 190 Glu Gly Val Ile Val Leu Ala Asn Ser Gly Leu Phe Ser Ile Phe Ser 195 200 205 Phe Leu Leu Leu Val Ser Ser Tyr Ile Val Ile Leu Phe Asn Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 His Ile Met Val Val Leu Leu Phe Phe Gly Pro Ala Ile Phe Leu Tyr 245 250 255 Met Arg Pro Pro Ser Thr Phe Thr Glu Asp Lys Leu Val Ala Val Phe 260 265 270 Tyr Thr Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp Gly Lys Lys Val 290 295 300 Asn Ser Gly Met Gly

<210> 669 <211> 930 <212> DNA

305

Page 748

069269_0225_SL.TXT <213> Canis familiaris <400> 669 atggaatcca ctacaaataa tgtgactgaa ttaatcttcg ttggcctttt ccaggatcca 60 gaggttcaga gagtgtgttt tgtggtattt cttctcatgt acctggccac ggtggtgggc 120 aatggcctca ttgtcctgac agtcaatgtc agtaagagtc tgcattcccc catgtacttc 180 ttccttagct acctgtccct ggtggagatc acgtactcct ctactgttgt ccctaaattc 240 atcacagact tacttactaa gattaaaacc atttccctgg aaggctgtgt agctcagata 300 ttcttcttcc acttctttgg ggtcactgag atccttttgc ttgtggtgat ggcctatgac 360 cgctatgtgg ctatttgcag gcctcttcat tatatgaata ttatgagccg ccaactatgt 420 catatactgg tggctggctc ctggcttggc ggcttttttc actccattat acagattctt 480 atcaccatcc agttgccctt ctgtggcccc aatgtgattg accactactt ctgtgatctt 540 cagccattat tcaaacttgc ctgcactgac acctttgtgg agggggttat tgtgttgacc 600 aacagtggct taattgctct gtgctccttc cttatcttgg tgtcttccta tattgtcatc 660 ctgttcaact tgaggaacca ttctgcagag gggaggcgca aagctctctc tacctgtgcc 720 tctcacatca tggtggtcct cttgttcttt ggacctgcca tctttctcta catgcgacct 780 tcctccacct tcactgagga caaactggtg gctgtgttct acacggttgt cacacccatg 840 ctgaacccca tcatctacac actcagaaat gcagaggtga aaaatgccat gagaaagttg 900 tggagcaaaa agaactcagg gatggaatga 930 <210> 670 <211> 309 <212> PRT <213> Canis familiaris <400> 670

Met 1 Glu Ser Thr Thr Asn Asn Val Thr Glu Leu Ile Phe Val Gly Leu 5 10 15 Phe Gln Asp Pro Glu Val Gln Arg Val Cys Phe Val Val Phe Leu Leu 20 25 30 Met Tyr Leu Ala Thr Val Val Gly Asn Gly Leu Ile Val Leu Thr Val 35 40 45

Page 749

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Val 50 Ser Lys Ser Leu His 55 Ser Pro Met Tyr Phe Phe Leu Ser Tyr 60 Ser Leu Val Glu Ile Thr Tyr Ser Ser Thr Val Val Pro Lys Phe 70 75 80 Thr Asp Leu Leu Thr Lys Ile Lys Thr Ile Ser Leu Glu Gly Cys 85 90 95 Ala Gln Ile Phe Phe Phe His Phe Phe Gly Val Thr Glu Ile Leu 100 105 110 Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro 115 120 125 His Tyr Met Asn Ile Met Ser Arg Gln Leu Cys His Ile Leu Val 130 135 140 Gly Ser Trp Leu Gly Gly Phe Phe His Ser Ile Ile Gln Ile Leu 150 155 160 Thr Ile Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr 165 170 175 Cys Asp Leu Gln Pro Leu Phe Lys Leu Ala Cys Thr Asp Thr Phe 180 185 190 Glu Gly Val Ile Val Leu Thr Asn Ser Gly Leu Ile Ala Leu Cys 195 200 205 Phe Leu Ile Leu Val Ser Ser Tyr Ile Val Ile Leu Phe Asn Leu 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala 230 235 240 His Ile Met Val Val Leu Leu Phe Phe Gly Pro Ala Ile Phe Leu 245 250 255

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Tyr Met Arg Pro Ser Ser Thr Phe Thr Glu Asp Lys Leu Val Ala 270 Val 260 265 Phe Tyr Thr Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Thr Leu 275 280 285 Arg Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp Ser Lys Lys 290 295 300

Asn Ser Gly Met Glu

305 <210> 671 <211> 1110 <212> DNA <213> Canis familiaris <400> 671 atggtaccat gttcccaaat ccaattttcc ttcaattttc ttcatataga taatgctaca ctgtatttct ctcttgtgaa cttcccaggt tccatggaaa ataatgttac tgagtttatc ttcatgggtc tttcccaaaa tgagaaagtg caacaactat gcttcttttt gttcttattc ttttatatga tactcatgac tggaaatttt ctcattataa tgactattca aaggagttca aatctcaact ctcccatgta ctttttcctt agcttcctat catttgtgga catctgctat tcctctgtta cagctcccaa gctgattatt gattcctacg ccaaagtcaa gagcatctcc tttgttggtt gtatggccca gctctttttc tgccatctat ttggctgcac agagatcttc attctcacag tgatggccta tgacaggtat gtggctatct gtaagcctct acgctatatg accatcatgg accggaaggt ctgctccata ctggtggcaa cctgttggtt aggagggttt gtgcattcct ttatccagac catcctcact gtacaactgc ctttctgtgg ccctaaccta attgaccact acttctgtga tgtccaccct ttactgaagc tggcttgcat agacacaaaa gttgtgggac tcattgtgat agcaaacagt ggtatgattt cactgagctg ttttgtcatt cttgttggct cttacattgt catcttgctt tcctttaaga cccgttcatc agaagggagg cgtaaggccc tgtccacatg tgcttctcac atcatagtgg tgatcttgtt ttttgtcccc

120

180

240

300

360

420

480

540

600

660

720

780

840

Page 751

069269_0225_SL.TXT tgcctcttca tctacctaag gccttccacc acttttactg aagacaagat ggtggctgtg 900 ttttatacca tcatcacacc catgttaaac cctctgatct ataccctgag aaacatggaa 960 gtgaaaaatg ccatgaagag actgtggatg gagaagttgg tggtcagaaa taagagaggc 1020 tctggtgtaa acctcaatgg gattgataga gcttcagttg taccagtttc caaaaggatt 1080 gctgggaaca agtcagtaat catcccttaa 1110 <210> 672 <211> 369 <212> PRT <213> Canis familiaris <400> 672

Met Val Pro Cys Ser Gln Ile Gln Phe Ser Phe Asn Phe Leu His Ile 1 5 10 15

Asp Asn Ala Thr Leu Tyr Phe Ser Leu Val Asn Phe Pro Gly Ser Met 20 25 30

Glu Asn Asn Val Thr Glu Phe Ile Phe Met Gly Leu Ser Gln Asn Glu 35 40 45

Lys Val Gln Gln Leu Cys Phe Phe Leu Phe Leu Phe Phe Tyr Met Ile 50 55 60

Leu Met Thr Gly Asn Phe Leu Ile Ile Met Thr Ile Gln Arg Ser Ser 65 70 75 80

Asn Leu Asn Ser Pro Met Tyr Phe Phe Leu Ser Phe Leu Ser Phe Val 85 90 95

Asp Ile Cys Tyr Ser Ser Val Thr Ala Pro Lys Leu Ile Ile Asp Ser 100 105 110

Tyr Ala Lys Val Lys Ser Ile Ser Phe Val Gly Cys Met Ala Gln Leu 115 120 125

Phe Phe Cys His Leu Phe Gly Cys Thr Glu Ile Phe Ile Leu Thr Val 130 135 140

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Met 145 Ala Tyr Asp Arg Tyr 150 Val Ala Ile Cys Lys 155 Pro Leu Arg Tyr Met 160 Thr Ile Met Asp Arg Lys Val Cys Ser Ile Leu Val Ala Thr Cys Trp 165 170 175 Leu Gly Gly Phe Val His Ser Phe Ile Gln Thr Ile Leu Thr Val Gln 180 185 190 Leu Pro Phe Cys Gly Pro Asn Leu Ile Asp His Tyr Phe Cys Asp Val 195 200 205 His Pro Leu Leu Lys Leu Ala Cys Ile Asp Thr Lys Val Val Gly Leu 210 215 220 Ile Val Ile Ala Asn Ser Gly Met Ile Ser Leu Ser Cys Phe Val Ile 225 230 235 240 Leu Val Gly Ser Tyr Ile Val Ile Leu Leu Ser Phe Lys Thr Arg Ser 245 250 255 Ser Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser His Ile Ile 260 265 270 Val Val Ile Leu Phe Phe Val Pro Cys Leu Phe Ile Tyr Leu Arg Pro 275 280 285 Ser Thr Thr Phe Thr Glu Asp Lys Met Val Ala Val Phe Tyr Thr Ile 290 295 300 Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Met Glu 305 310 315 320 Val Lys Asn Ala Met Lys Arg Leu Trp Met Glu Lys Leu Val Val Arg 325 330 335 Asn Lys Arg Gly Ser Gly Val Asn Leu Asn Gly Ile Asp Arg Ala Ser 340 345 350

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Val Val Pro Val Ser Lys Arg Ile Ala Gly Asn Lys Ser Val Ile Ile 355 360 365

Pro <210> 673 <211> 939 <212> DNA <213> Canis familiaris <400> 673

atgagcaacc atacaacagt gactgaattt attcttgtgg gattcgggga tcatccagaa 60 ctactgtgcc ttctttttat ggtgtttctg gtcgtctata tgatcactgt atttggaaat 120 cttggcatga tcctattaat caagattgac tcacatctcc atactccaat gtattttttc 180 ctcagtaact tatcccttgt tgatttctgt tattcttctg tcattgcccc taatatgcta 240 gtgaatttct gggtggagaa cccagtcatt tcatttaatg gatgtgccac tcaattcttc 300 ttttttggtt cctttgccgg cattgagggc ttcctgttgg ccgtgatggc ttatgaccgt 360 tatgtggcca tctgcaagcc tcttctttat gcagttatta tgtctcccca tcttaatgtc 420 cttctggtgt tggccacgta tcttgcaggc tttctgaatg ctgccattca cactggcttc 480 acctttcggc tgtctttctg ccgttcaaat gtcatcaacc actttttctg tgacactcca 540 cccctcctga aactctcttg ttctgataca catatcaatg aagttgtcat ttttgctttt 600 gccagtttta atgaactgag ctgcctcttg attattctca tttcttatct gtacatactc 660 attgccattt tgaggatcca ttctgctgaa gggaggcaca aagccttttc cacctgtgct 720 tcccacttga tggtggttac catcttcttt ggtacaattc tgtttatgta tctgcgcccc 780 agctccagct actcaatgga ccaggacaaa gtggtatctg tgttttatac agtggtcatc 840 cctatgttaa atcctctcat ctatagtctg agaaacaagg aggtcaaagc ttccttaggt 900 aaaattttta aaacaacttg tttttacctc tgtacttag 939

<210> 674 <211> 312 <212> PRT <213> Canis familiaris

Page 754

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<400> 674 Ile Leu Val Gly Phe Gly 15 Met 1 Ser Asn His Thr Thr 5 Val Thr Glu Phe 10 Asp His Pro Glu Leu Leu Cys Leu Leu Phe Met Val Phe Leu Val Val 20 25 30 Tyr Met Ile Thr Val Phe Gly Asn Leu Gly Met Ile Leu Leu Ile Lys 35 40 45 Ile Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Cys Tyr Ser Ser Val Ile Ala Pro Asn Met Leu 65 70 75 80 Val Asn Phe Trp Val Glu Asn Pro Val Ile Ser Phe Asn Gly Cys Ala 85 90 95 Thr Gln Phe Phe Phe Phe Gly Ser Phe Ala Gly Ile Glu Gly Phe Leu 100 105 110 Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Leu Tyr Ala Val Ile Met Ser Pro His Leu Asn Val Leu Leu Val Leu 130 135 140 Ala Thr Tyr Leu Ala Gly Phe Leu Asn Ala Ala Ile His Thr Gly Phe 145 150 155 160 Thr Phe Arg Leu Ser Phe Cys Arg Ser Asn Val Ile Asn His Phe Phe 165 170 175 Cys Asp Thr Pro Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr His Ile 180 185 190 Asn Glu Val Val Ile Phe Ala Phe Ala Ser Phe Asn Glu Leu Ser Cys 195 200 205

Page 755

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Leu Leu Ile Ile Leu Ile Ser Tyr Leu Tyr Ile Leu Ile Ala Ile Leu 210 215 220 Arg Ile His Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Met Val Val Thr Ile Phe Phe Gly Thr Ile Leu Phe Met 245 250 255 Tyr Leu Arg Pro Ser Ser Ser Tyr Ser Met Asp Gln Asp Lys Val Val 260 265 270 Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Ala Ser Leu Gly Lys Ile Phe Lys 290 295 300 Thr Thr Cys Phe Tyr Leu Cys Thr 305 310

<210> 675 <211> 969 <212> DNA <213> Canis familiaris <400> 675

atgtcttcct cgaaccacac ttcagtgacg ggattcattc tcttgggact cacagacgac 60 ccagtactag agaagatcct gtttggggtg tttctggtga tctatctagt cacgctggca 120 gggaatctgt gcatgattgt gctgatcggg accaattccc acctgcaaac tcccatgtac 180 ttcttcctta gccacctctc ctttgtagac atctgctatt cttccaatat cactccaaac 240 atgctgtata atttcctctc agaccagaag accatctcct atgctggatg cttcacgcag 300 tgtcttctct tcattgccct ggtgatcact gagttttaca tccttgcttc aatggcattg 360 gatcgctatg tagccatctg tagccctcta cattacagta ccagaatgtc caagaacatt 420 tgcatctccc tagtggtgat ctcttatact tgtggttacc ttaatggact ctcccagaca 480

Page 756

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ctgttgactt ttcacttgtc cttctgtgac tcccttgaaa tcaaccactt ctactgtgca 540 gatcctcctc ttatcctgtt ggcctgctct gacacccatg tcaaaaagat ggcgatgctg 600 gtagtagctg gcttgactct gtcaagctct ctcttcatca ttgtgctatc ctactttttc 660 attattgtag ccatcttgag gatccgttct gctgaaggca ggcacaaagc cttttctact 720 tgtgcttccc acttgacaat agtcacctta ttttatggca ccctcttctg catgtactta 780 aggagtccat ctgagaagtc tgtagaggag tccaaaataa ttgctgtctt ttatacgttt 840 ttaagcccaa tgttgaaccc attgatttat agtctaagga acaaggatgt gatccatgct 900 atgcagcaaa tgattaaggg aaatctcttt catacaattg aaatttgggt ctctgttaat 960

ttgaaatga 969 <210> 676 <211> 322 <212> PRT <213> Canis familiaris <400> 676

Met Ser Ser Ser Asn His Thr Ser Val Thr Gly Phe Ile Leu Leu Gly 1 5 10 15 Leu Thr Asp Asp Pro Val Leu Glu Lys Ile Leu Phe Gly Val Phe Leu 20 25 30 Val Ile Tyr Leu Val Thr Leu Ala Gly Asn Leu Cys Met Ile Val Leu 35 40 45 Ile Gly Thr Asn Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Asn Ile Thr Pro Asn 65 70 75 80 Met Leu Tyr Asn Phe Leu Ser Asp Gln Lys Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Phe Thr Gln Cys Leu Leu Phe Ile Ala Leu Val Ile Thr Glu Phe 100 105 110

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Tyr Ile Leu 115 Ala Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Ser 120 125 Pro Leu His Tyr Ser Thr Arg Met Ser Lys Asn Ile Cys Ile Ser Leu 130 135 140 Val Val Ile Ser Tyr Thr Cys Gly Tyr Leu Asn Gly Leu Ser Gln Thr 145 150 155 160 Leu Leu Thr Phe His Leu Ser Phe Cys Asp Ser Leu Glu Ile Asn His 165 170 175 Phe Tyr Cys Ala Asp Pro Pro Leu Ile Leu Leu Ala Cys Ser Asp Thr 180 185 190 His Val Lys Lys Met Ala Met Leu Val Val Ala Gly Leu Thr Leu Ser 195 200 205 Ser Ser Leu Phe Ile Ile Val Leu Ser Tyr Phe Phe Ile Ile Val Ala 210 215 220 Ile Leu Arg Ile Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ile Val Thr Leu Phe Tyr Gly Thr Leu Phe 245 250 255 Cys Met Tyr Leu Arg Ser Pro Ser Glu Lys Ser Val Glu Glu Ser Lys 260 265 270 Ile Ile Ala Val Phe Tyr Thr Phe Leu Ser Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Ile His Ala Met Gln Gln Met 290 295 300 Ile Lys Gly Asn Leu Phe His Thr Ile Glu Ile Trp Val Ser Val Asn 305 310 315 320

Page 758

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Leu Lys <210> 677 <211> 930 <212> DNA <213> Canis familiaris <400> 677

atggaacaaa acaatggcac taaagtaact gaattcatcc tcctgggatt tgctggtcaa 60 cacaagtctt ggcatatcct cttcatagca tttctagtga tctatgtggc caccctaatg 120 gggaatattg ggatgatcct actcatcaag attgattctc gccttcacac cccaatgtac 180 ttttttctcc aacacctggc atttgtggat ctctgctaca cctctgctat cactcccaag 240 atgctgcaaa accttgtaga aacagagcaa tccatctcat tcataggatg tatggtgcaa 300 ttactagtct atggagcttt tgcaacaacc gactgctaca tcctggctgc aatggcagtg 360 gacaggtatg tggccatctg caacccactc cgctatccga cagtcatgtc ccaggcagtc 420 tgcattcaac tcctgattgg ctcatacttc gtaggcttct tgaatgcctc tgtaaacaca 480 agttttgctt tttcattgaa cttttgcaaa tccaataaaa ttaaccactt tttctgtgat 540 gaacccccac tccttgccct ctcgtgctcc aacattgact tcaacatcat gctactaact 600 gtctttgtgg ggtttaactt gatgttcact gtgctggttg tcatcttttc ctacatatat 660 attctggctg ccatcctgaa gatatcttct gctgcaggga ggaagaaagc cttctccaca 720 tgcgcctccc acctgacagc catcactgtg ttctatggga ctctctctta catgtacctg 780 catcatggga ccaaggagtc tcaagagcaa gaaaaaatgg cttctgtgtt ttatggcatt 840 atgatcccca tgttaaaccc cctcatctac agcctgagaa accaagatgt gaaggaagcc 900 ctaaaaggga ttcgaaagaa ggctttctag 930

<210> 678 <211> 309 <212> PRT <213> Canis familiaris <400> 678

Met Glu Gln Asn Asn Gly Thr Lys Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15

Page 759

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Phe Ala Gly Gln His Lys Ser Trp His Ile Leu Phe Ile Ala Phe Leu 20 25 30 Val Ile Tyr Val Ala Thr Leu Met Gly Asn Ile Gly Met Ile Leu Leu 35 40 45 Ile Lys Ile Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gln 50 55 60 His Leu Ala Phe Val Asp Leu Cys Tyr Thr Ser Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Gln Asn Leu Val Glu Thr Glu Gln Ser Ile Ser Phe Ile Gly 85 90 95 Cys Met Val Gln Leu Leu Val Tyr Gly Ala Phe Ala Thr Thr Asp Cys 100 105 110 Tyr Ile Leu Ala Ala Met Ala Val Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Thr Val Met Ser Gln Ala Val Cys Ile Gln Leu 130 135 140 Leu Ile Gly Ser Tyr Phe Val Gly Phe Leu Asn Ala Ser Val Asn Thr 145 150 155 160 Ser Phe Ala Phe Ser Leu Asn Phe Cys Lys Ser Asn Lys Ile Asn His 165 170 175 Phe Phe Cys Asp Glu Pro Pro Leu Leu Ala Leu Ser Cys Ser Asn Ile 180 185 190 Asp Phe Asn Ile Met Leu Leu Thr Val Phe Val Gly Phe Asn Leu Met 195 200 205 Phe Thr Val Leu Val Val Ile Phe Ser Tyr Ile Tyr Ile Leu Ala Ala 210 215 220

Page 760

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Ile 225 Leu Lys Ile Ser Ser Ala Ala Gly Arg Lys Lys Ala Phe Ser Thr 240 230 235 Cys Ala Ser His Leu Thr Ala Ile Thr Val Phe Tyr Gly Thr Leu Ser 245 250 255 Tyr Met Tyr Leu His His Gly Thr Lys Glu Ser Gln Glu Gln Glu Lys 260 265 270 Met Ala Ser Val Phe Tyr Gly Ile Met Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Asp Val Lys Glu Ala Leu Lys Gly Ile 290 295 300

Arg Lys Lys Ala Phe 305 <210> 679 <211> 948 <212> DNA <213> Canis familiaris <400> 679

atgtcttcct cgaaccacac ttcagtgacg ggattcattc tcctgggact cacagatgac 60 ccagtactag agaagatcct gtttggggtg tttctggtga tctatctagt cacactggca 120 gggaatctgt gcatgattgt actgatcggg accaattccc acctgcaaac tcccatgtac 180 ttcttcctta gccacctctc ctttgtagac atctgctatt cttccaatat cactccaaac 240 atgctgtaca atttcctctc agaccagaag accatctcct atgctggatg cttcacgcag 300 tgtcttctct tcattgccct ggtgatcact gagttttaca tccttgcttc aatggcattg 360 gatcgctatg tagccatctg tagccctcta cattacagta ccagaatgtc caagaacatt 420 tgcatctccc tagtggtgat ctcttatact tgtggttacc ttaatggact ctcccagaca 480 ctgttgactt ttcacttgtc cttctgtgac tcccttgaaa tcaaccactt ctactgtgca 540 gatcctcctc ttatcctgtt ggcctgctct gacacccatg tcaaaaagat ggcgatgctg 600

Page 761

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gtagtagctg gcttgactct gtcaagctct ctcttcatca ttgtgctatc ctaccttttc 660 attattgtag ccatcttgag gatccgttct gctgaaggca ggcacaaagc cttttctact 720 tgtgcttccc acttgacaac agtcactttg ttttatggca ccctcttctg catgtactta 780 aggagtccat ctgagaagtc tatagaggag tctaaaataa ttgctgtctt ttatacattt 840 ttaagcccaa tgttgaaccc attgatttat agtctaagga acaaggatgt gatccatgct 900 atgcagcaaa tcattcaggg aaatattttt cataaaattg cagtgtag 948

<210> 680 <211> 315 <212> PRT <213> Canis familiaris <400> 680

Met 1 Ser Ser Ser Asn His Thr Ser Val Thr Gly Phe Ile Leu Leu Gly 5 10 15 Leu Thr Asp Asp Pro Val Leu Glu Lys Ile Leu Phe Gly Val Phe Leu 20 25 30 Val Ile Tyr Leu Val Thr Leu Ala Gly Asn Leu Cys Met Ile Val Leu 35 40 45 Ile Gly Thr Asn Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Asn Ile Thr Pro Asn 65 70 75 80 Met Leu Tyr Asn Phe Leu Ser Asp Gln Lys Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Phe Thr Gln Cys Leu Leu Phe Ile Ala Leu Val Ile Thr Glu Phe 100 105 110 Tyr Ile Leu Ala Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu His Tyr Ser Thr Arg Met Ser Lys Asn Ile Cys Ile Ser Leu

Page 762

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130 135 140

Val 145 Val Ile Ser Tyr Thr 150 Cys Gly Tyr Leu Asn Gly Leu Ser Gln Thr 155 160 Leu Leu Thr Phe His Leu Ser Phe Cys Asp Ser Leu Glu Ile Asn His 165 170 175 Phe Tyr Cys Ala Asp Pro Pro Leu Ile Leu Leu Ala Cys Ser Asp Thr 180 185 190 His Val Lys Lys Met Ala Met Leu Val Val Ala Gly Leu Thr Leu Ser 195 200 205 Ser Ser Leu Phe Ile Ile Val Leu Ser Tyr Leu Phe Ile Ile Val Ala 210 215 220 Ile Leu Arg Ile Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Thr Val Thr Leu Phe Tyr Gly Thr Leu Phe 245 250 255 Cys Met Tyr Leu Arg Ser Pro Ser Glu Lys Ser Ile Glu Glu Ser Lys 260 265 270 Ile Ile Ala Val Phe Tyr Thr Phe Leu Ser Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Ile His Ala Met Gln Gln Ile 290 295 300 Ile Gln Gly Asn Ile Phe His Lys Ile Ala Val

305 310 315 <210> 681 <211> 984 <212> DNA <213> Canis familiaris

Page 763

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<400> 681 atgaagatgg acatatttct cccacacaac agcactgaag caactgagtt catcctgctg 60 ggactgacca gccaacaaga gctgcaaccc atcctttttg tggtgtttct actgatttac 120 atcatcaccc tgacaggaaa ctttggattg attgcattaa tcagattcac tccccggctg 180 caaacaccca tgtacttttt cctcacccac ttagcatgcg tggatatttt ttattctact 240 aatgtctctc ctcagatgct tgttaatttc ctctctgaga agaaaactat ttcctacaca 300 gggtgtctgg cccagtgttt tgtttttgtg actctgctcc ttactgagta ttacatgctt 360 ggtgccatgg cctatgacag gtacatggca atctgccatc cgctgcatta caacagcaga 420 atgtccaggc cactttgcat ctgccttgtc acttttccct acctctgggg ttctatggtg 480 ggcacaatgc aagtaatatt gacctctcgc ttgtcctttt gtggacctaa catcatcaat 540 catttctact gtgctgaccc acctctcctc atgctgacgt gttctgacac ttacataaag 600 cagactgcac tatttgtgtc tgcggggatt aacctcactg gttccctact catcatcctc 660 atctcttatg ttttcatttt tatcaccatt atgaggatcc attccagtga agggcaatgc 720 aaagccttct ccacctgtgg ctctcacctg accgctgtca ccatgttcta tgggtcccta 780 ttctgcatgt atctgagacc agcaaatgag cagtctgttg aacaagggaa aattgtggca 840 gtggtctgta tctttgtgag tcccatgttg aacccattta tctacagcct gaggaacaaa 900 gatgtgaagc aggctttgag aatagtattt acgaggaaac ttggtacagt ggagaaaatg 960 tctattttga cagtctccca atga 984

<210> 682 <211> 327 <212> PRT <213> Canis familiaris <400> 682

Met 1 Lys Met Asp Ile 5 Phe Leu Pro His Asn Ser Thr Glu Ala Thr Glu 10 15 Phe Ile Leu Leu Gly Leu Thr Ser Gln Gln Glu Leu Gln Pro Ile Leu 20 25 30 Phe Val Val Phe Leu Leu Ile Tyr Ile Ile Thr Leu Thr Gly Asn Phe 35 40 45

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Gly Leu 50 Ile Ala Leu Ile Arg Phe 55 Thr Pro Arg Leu Gln Thr Pro 60 Met Tyr Phe Phe Leu Thr His Leu Ala Cys Val Asp Ile Phe Tyr Ser Thr 65 70 75 80 Asn Val Ser Pro Gln Met Leu Val Asn Phe Leu Ser Glu Lys Lys Thr 85 90 95 Ile Ser Tyr Thr Gly Cys Leu Ala Gln Cys Phe Val Phe Val Thr Leu 100 105 110 Leu Leu Thr Glu Tyr Tyr Met Leu Gly Ala Met Ala Tyr Asp Arg Tyr 115 120 125 Met Ala Ile Cys His Pro Leu His Tyr Asn Ser Arg Met Ser Arg Pro 130 135 140 Leu Cys Ile Cys Leu Val Thr Phe Pro Tyr Leu Trp Gly Ser Met Val 145 150 155 160 Gly Thr Met Gln Val Ile Leu Thr Ser Arg Leu Ser Phe Cys Gly Pro 165 170 175 Asn Ile Ile Asn His Phe Tyr Cys Ala Asp Pro Pro Leu Leu Met Leu 180 185 190 Thr Cys Ser Asp Thr Tyr Ile Lys Gln Thr Ala Leu Phe Val Ser Ala 195 200 205 Gly Ile Asn Leu Thr Gly Ser Leu Leu Ile Ile Leu Ile Ser Tyr Val 210 215 220 Phe Ile Phe Ile Thr Ile Met Arg Ile His Ser Ser Glu Gly Gln Cys 225 230 235 240 Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Ala Val Thr Met Phe 245 250 255

Page 765

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Tyr Gly Ser Leu Phe Cys Met Tyr Leu Arg Pro Ala Asn Glu Gln Ser 260 265 270 Val Glu Gln Gly Lys Ile Val Ala Val Val Cys Ile Phe Val Ser Pro 275 280 285 Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gln 290 295 300 Ala Leu Arg Ile Val Phe Thr Arg Lys Leu Gly Thr Val Glu Lys Met 305 310 315 320 Ser Ile Leu Thr Val Ser Gln

325 <210> 683 <211> 936 <212> DNA <213> Canis familiaris <400> 683 atgttaaaga acaactacac agcagtgact gagtttattc tcctgggact gacagatcaa gctgagttac agcctgtcct ttttgtggtc ttcctagtca tctaccttat cacagtgctt ggcaatgtta gcatgatttt gttaatcaga agtgactcaa aacttcacac tccaatgtac ttcttcctca gtcatctctc ttttgtggac ctctgttata ccaccagtgt cgctccacag atgctggttc atttcttatc caagagaaaa gccatttcct tcctgggttg ccttctgcaa ttccactttt tcattgccct ggtgatcacc gattattata tgctcacagt gatggcctat gaccgctacg tggccatctg caaacccctg ttgtatggca gcaagatgtc caggtgtgtc tgcttctctc tcgttgccac cccttatatt tatggctttg tgaatggtct ggcacagacc atcctgatgc ttcgcctctc cttctgtgga cccaatgaaa tcaaccactt ttactgtgca gacccacctc tcatagtcct tgcctgctca gatacttatg tcaaagaaac tgccatgttt gtggtggctg gtttcaatct cacctgttct ctagccatca ttctcatctc atacattttc attttctcca ccattctgcg catccactct gctgagggca ggcgcaaagc cttctccacc

120

180

240

300

360

420

480

540

600

660

720

Page 766

069269_0225_SL.TXT tgtgggtccc atttgacggc tgtcaccatc ttttatggga ctctgttctg catgcaccta agaccccctt ctgagacatc tgtagaacag agcaaaattg ttgccgtgtt ttatatcttt gtgagtccta tgttaaaccc ttttatttat agcctgcgga acaaagatgt taaaaatgca atcaggaaag ttttccaaag gaaattgtta aattaa

780

840

900

936 <210> 684 <211> 311 <212> PRT <213> Canis familiaris <400> 684

Met 1 Leu Lys Asn Asn 5 Tyr Thr Ala Val Thr Glu Phe Ile Leu Leu Gly 10 15 Leu Thr Asp Gln Ala Glu Leu Gln Pro Val Leu Phe Val Val Phe Leu 20 25 30 Val Ile Tyr Leu Ile Thr Val Leu Gly Asn Val Ser Met Ile Leu Leu 35 40 45 Ile Arg Ser Asp Ser Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Leu Cys Tyr Thr Thr Ser Val Ala Pro Gln 65 70 75 80 Met Leu Val His Phe Leu Ser Lys Arg Lys Ala Ile Ser Phe Leu Gly 85 90 95 Cys Leu Leu Gln Phe His Phe Phe Ile Ala Leu Val Ile Thr Asp Tyr 100 105 110 Tyr Met Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Gly Ser Lys Met Ser Arg Cys Val Cys Phe Ser Leu 130 135 140 Val Ala Thr Pro Tyr Ile Tyr Gly Phe Val Asn Gly Leu Ala Gln Thr

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145 150 155 160 Ile Leu Met Leu Arg Leu Ser Phe Cys Gly Pro Asn Glu Ile Asn His 165 170 175 Phe Tyr Cys Ala Asp Pro Pro Leu Ile Val Leu Ala Cys Ser Asp Thr 180 185 190 Tyr Val Lys Glu Thr Ala Met Phe Val Val Ala Gly Phe Asn Leu Thr 195 200 205 Cys Ser Leu Ala Ile Ile Leu Ile Ser Tyr Ile Phe Ile Phe Ser Thr 210 215 220 Ile Leu Arg Ile His Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Leu Phe 245 250 255 Cys Met His Leu Arg Pro Pro Ser Glu Thr Ser Val Glu Gln Ser Lys 260 265 270 Ile Val Ala Val Phe Tyr Ile Phe Val Ser Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Ile Arg Lys Val 290 295 300 Phe Gln Arg Lys Leu Leu Asn 305 310

<210> 685 <211> 936 <212> DNA <213> Canis familiaris <400> 685 atgttaaaga acaactacac agcagtgact gagtttattc tcctgggact gacagatcga gctgagttgc agcctgtcct ttttgtggtc ttcctagtca tctaccttat cacagtgctt Page 768

120

069269_0225_SL.TXT

ggcaatgtta gcatgatctt gttaatcaga agtgactcaa aacttcacac tccgatgtac 180 ttcttcctca gtcatctctc ttttgtggac ctctgttata ccaccaatgt ctctccacag 240 atgctggttc atttcttatc cgagagaaaa gccatttcct tcctgggttg ccttctgcaa 300 ttccactttt tcattgccct ggtgatcacc gattattata tgctcacagt gatggcctat 360 gaccgctacg tggccatctg caaacccctg ttgtatggca gcaagatgtc caggtgtgtc 420 tgcttctctc tcgttgccac cccttatatt tatggctttg tgaatggtct ggcacagacc 480 atcctgatgc ttcgcctctc cttctgtgga cccaatgaaa tcaaccactt ttactgtgca 540 gacccacctc tcatagtcct tgcctgctca gatacttatg tcaaagaaac tgccatgttt 600 gtggtggctg gtttcaatct cacctgttct ctagccatca ttctcatctc atacattttc 660 attttctcca ccattctgcg catccactct gctgagggca ggcgcaaagc cttctccacc 720 tgtgggtccc atttgacggc tgtcaccatc ttttatggga ctctgttctg catgtacctg 780 agacctcctt ctgagacatc tgtagaacag agcaaaattg ttgccgtgtt ttatatcttt 840 gtgagtccta tgttaaaccc ttttatttat agcctgcgga acaaagatgt taaaaatgca 900 atcaggaaag ttttccaaag gaaattgtta aattaa 936

<210> 686 <211> 311 <212> PRT <213> Canis familiaris <400> 686

Met 1 Leu Lys Asn Asn 5 Tyr Thr Ala Val Thr Glu Phe Ile Leu 10 Leu 15 Gly Leu Thr Asp Arg Ala Glu Leu Gln Pro Val Leu Phe Val Val Phe Leu 20 25 30 Val Ile Tyr Leu Ile Thr Val Leu Gly Asn Val Ser Met Ile Leu Leu 35 40 45 Ile Arg Ser Asp Ser Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60

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His 65 Leu Ser Phe Val Asp Leu Cys Tyr Thr Thr Asn Val Ser Pro Gln 70 75 80 Met Leu Val His Phe Leu Ser Glu Arg Lys Ala Ile Ser Phe Leu Gly 85 90 95 Cys Leu Leu Gln Phe His Phe Phe Ile Ala Leu Val Ile Thr Asp Tyr 100 105 110 Tyr Met Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Gly Ser Lys Met Ser Arg Cys Val Cys Phe Ser Leu 130 135 140 Val Ala Thr Pro Tyr Ile Tyr Gly Phe Val Asn Gly Leu Ala Gln Thr 145 150 155 160 Ile Leu Met Leu Arg Leu Ser Phe Cys Gly Pro Asn Glu Ile Asn His 165 170 175 Phe Tyr Cys Ala Asp Pro Pro Leu Ile Val Leu Ala Cys Ser Asp Thr 180 185 190 Tyr Val Lys Glu Thr Ala Met Phe Val Val Ala Gly Phe Asn Leu Thr 195 200 205 Cys Ser Leu Ala Ile Ile Leu Ile Ser Tyr Ile Phe Ile Phe Ser Thr 210 215 220 Ile Leu Arg Ile His Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Leu Phe 245 250 255 Cys Met Tyr Leu Arg Pro Pro Ser Glu Thr Ser Val Glu Gln Ser Lys 260 265 270

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Ile Val Ala Val Phe Tyr Ile Phe Val Ser Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Ile Arg Lys Val 290 295 300 Phe Gln Arg Lys Leu Leu Asn 305 310

<210> 687 <211> 969 <212> DNA <213> Canis familiaris <400> 687

atgtccatca caaatgacag tgcaataaga gaattcattc tcctggggct cacagatcgt 60 cccgagctcc aacctctcct ctttgtgctg tttctgggtg tgtacctcgt caccctcttg 120 ggcaacctgg gcatgatggt attaatcagg ctggactccc gccttcacaa acccatgtac 180 ttcttcctca ctaatttggc ctttgtagac ttgtgctaca cctcaaatgc aaccccgcag 240 atgttgacta attttttatc agagaagaag accatcagtt ttgctggctg ctttacgcag 300 tgttacattt tcattgcact tctcctcact gagttttaca tgctggcagc aatggcctat 360 gaccgctatg tggccatatg taaccctcta cattatagta tgaaaatgtc caggcgtgtc 420 tgcatcggct tggccacatt tccttatgtc tatggattct cagatgggct cttgcaggct 480 atcctgacct ttcgcttgaa cttctgtaga tccaatgtca tcaaccactt ctactgtgct 540 gacccgccac tgattaagct ttcttgctct gatacttatg tcaaagagca tgccatgctc 600 atatcagctg gcttcaacct ctccaactcc ctcagcatca tcctggtatc ctatgctttc 660 attattgctg ccatcctccg gatcaaatca gcagagggaa gacagaaggc attctccacc 720 tgtggttccc acatgatggc tgtgacctta ttttatggga cgctcttctg catgtatgta 780 agaccaccaa cagataagac tgtcgaggaa tccaaaatca tagcagtctt ctacactttt 840 gtgagtccag tgcttaatcc actgatatac agtctgcgga acaaagatgt aaagcaagcc 900 ttgaagaatg tcctcagaag aaatatgatc attaagatga gactgcctcc agtttccaat 960

aaatcataa 969

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069269_0225_SL.TXT <210> 688 <211> 322 <212> PRT <213> Canis familiaris <400> 688

Met 1 Ser Ile Thr Asn Asp Ser Ala Ile Arg Glu Phe Ile Leu Leu Gly 5 10 15 Leu Thr Asp Arg Pro Glu Leu Gln Pro Leu Leu Phe Val Leu Phe Leu 20 25 30 Gly Val Tyr Leu Val Thr Leu Leu Gly Asn Leu Gly Met Met Val Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Lys Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ala Phe Val Asp Leu Cys Tyr Thr Ser Asn Ala Thr Pro Gln 65 70 75 80 Met Leu Thr Asn Phe Leu Ser Glu Lys Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Phe Thr Gln Cys Tyr Ile Phe Ile Ala Leu Leu Leu Thr Glu Phe 100 105 110 Tyr Met Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu His Tyr Ser Met Lys Met Ser Arg Arg Val Cys Ile Gly Leu 130 135 140 Ala Thr Phe Pro Tyr Val Tyr Gly Phe Ser Asp Gly Leu Leu Gln Ala 145 150 155 160 Ile Leu Thr Phe Arg Leu Asn Phe Cys Arg Ser Asn Val Ile Asn His 165 170 175 Phe Tyr Cys Ala Asp Pro Pro Leu Ile Lys Leu Ser Cys Ser Asp Thr

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069269_0225_SL.TXT 185 190

Tyr Val Lys Glu His Ala Met Leu Ile Ser Ala Gly Phe Asn Leu Ser 195 200 205

Asn Ser Leu Ser Ile Ile Leu Val Ser Tyr Ala Phe Ile Ile Ala Ala 210 215 220

Ile Leu Arg Ile Lys Ser Ala Glu Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240

Cys Gly Ser His Met Met Ala Val Thr Leu Phe Tyr Gly Thr Leu Phe 245 250 255

Cys Met Tyr Val Arg Pro Pro Thr Asp Lys Thr Val Glu Glu Ser Lys 260 265 270

Ile Ile Ala Val Phe Tyr Thr Phe Val Ser Pro Val Leu Asn Pro Leu 275 280 285

Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gln Ala Leu Lys Asn Val 290 295 300

Leu Arg Arg Asn Met Ile Ile Lys Met Arg Leu Pro Pro Val Ser Asn 305 310 315 320

Lys Ser <210> 689 <211> 957 <212> DNA <213> Canis familiaris <400> 689 atgctgacag ctaagaaaat ggtcagagga aattccaccc tggtgactga atttgttctc ttgggattaa cagatcgtcc agagcttcag cccatccttt ttgtgctgtt cctgctgatc tacttgatca ctgtgtgtgg gaaccttggg atgttggtct tgattaagat agactcacgc ctccacactc ctatgtactt ctttcttgcc agtttgtcct gcttggactt gtgctattcc Page 773

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069269_0225_SL.TXT actaatgtga ctcccaagat gttggtgaat gctgcttgtt tagtccagtg ttattttttt ctggctgtaa tggcttatga taggtacatg aagatgtcca gaggagtctg tattcgcctg agtggcctga tggaaaccat gtggacctac aatcacttct attgcgctga ccctcccctc aaggagacat ccatgtttgt ggtagcagga ctcatctcct acatctttat tctcattgcc cacaaagcct tttccacctg tggatcccat ctgttctgca tgtatgtgag acctcccacg gctgttttct acacttttgt aagccctatg aagaatgtga aacaagcttt ttggaaattg <210> 690 <211> 318 <212> PRT <213> Canis familiaris ttcttatcag agaagaaaac catttcctat attgccatgg tgattacaga atattacatg gccatctgta accctttgct ttacagcagc attgttggtc catatgtcta tgggttcctt cgcttgacct tctgtggctc caatattatt atccagctct cctgctctga cactttcatt tttaacctct ccaactccct cctcataatc atcctgaaga tgcattctgc tgaagggagg ctggtggcag tgactgtgtt ttatgggact gacaagtcag tggagcagtc aaaaattatt ttgaatccta tcatttatag tctgaggaac atcaaaagaa atgtactttt gaaataa

300

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540

600

660

720

780

840

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957 <400> 690

Met 1 Leu Thr Ala Lys 5 Lys Met Val Glu Phe Val Leu 20 Leu Gly Leu Thr Leu Phe Val 35 Leu Phe Leu Leu Ile 40 Leu Gly 50 Met Leu Val Leu Ile 55 Lys Met 65 Tyr Phe Phe Leu Ala 70 Ser Leu

Arg Gly 10 Asn Ser Thr Leu Val 15 Thr Asp 25 Arg Pro Glu Leu Gln 30 Pro Ile Tyr Leu Ile Thr Val 45 Cys Gly Asn Ile Asp Ser Arg 60 Leu His Thr Pro Ser Cys Leu 75 Asp Leu Cys Tyr Ser 80

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Thr Asn Val Thr Pro 85 Lys Met 069269_0225_SL.TXT Leu Val Asn Phe Leu Ser 90 Glu Lys 95 Lys Thr Ile Ser Tyr Ala Ala Cys Leu Val Gln Cys Tyr Phe Phe Ile Ala 100 105 110 Met Val Ile Thr Glu Tyr Tyr Met Leu Ala Val Met Ala Tyr Asp Arg 115 120 125 Tyr Met Ala Ile Cys Asn Pro Leu Leu Tyr Ser Ser Lys Met Ser Arg 130 135 140 Gly Val Cys Ile Arg Leu Ile Val Gly Pro Tyr Val Tyr Gly Phe Leu 145 150 155 160 Ser Gly Leu Met Glu Thr Met Trp Thr Tyr Arg Leu Thr Phe Cys Gly 165 170 175 Ser Asn Ile Ile Asn His Phe Tyr Cys Ala Asp Pro Pro Leu Ile Gln 180 185 190 Leu Ser Cys Ser Asp Thr Phe Ile Lys Glu Thr Ser Met Phe Val Val 195 200 205 Ala Gly Phe Asn Leu Ser Asn Ser Leu Leu Ile Ile Leu Ile Ser Tyr 210 215 220 Ile Phe Ile Leu Ile Ala Ile Leu Lys Met His Ser Ala Glu Gly Arg 225 230 235 240 His Lys Ala Phe Ser Thr Cys Gly Ser His Leu Val Ala Val Thr Val 245 250 255 Phe Tyr Gly Thr Leu Phe Cys Met Tyr Val Arg Pro Pro Thr Asp Lys 260 265 270 Ser Val Glu Gln Ser Lys Ile Ile Ala Val Phe Tyr Thr Phe Val Ser 275 280 285

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Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asn Val Lys 290 295 300

Gln Ala Phe Trp Lys Leu Ile Lys Arg Asn Val Leu Leu Lys 305 310 315 <210> 691 <211> 936 <212> DNA <213> Canis familiaris <400> 691

atgagaagaa acttcacctc agtgactgag ttcattctcc tcggactgac cagtcgcctg 60 gagttgcaga tcgtcctctt cctgctgttt ctggccattt acttggtcac cctcgcaggg 120 aatcttggca tgattgtact catccaggtc aatgctcagc tccacaagcc catgtacttt 180 ttcctgagcc acttatcctt tgtggatctg tgcttctctt ccaacgtgac tcccaagatg 240 ctggaggttt tcttatcaga gaagaaaacc atttcctacc ctgcttgtct ggtgcagtgt 300 tacttcttta tcaccttggt gcacgtggag atctacatcc tggctgtgat ggcttttgat 360 cggtacatgg ccatctgcaa ccctctgctt tatggcagca agatgtccaa gagtgtgtgc 420 acatccctca tcacggggcc ttatgtgtac ggagcactca ctggcctcat ggagaccatg 480 tggacctaca acctagtctt ctgtggcccc aatgaaatta accacttcta ctgtgctgac 540 ccaccactga ttaagctggc ttgttctgac acttacaaca aagagctgtc aatgtttgtt 600 gtggcaggat gtaacctttc cttttctctg ctcatcatcc tgatttccta cctttatatt 660 gttcctgcta tcctgaagat tcgttcaaca gaaggcaggc ataaagcttt ctctacctgt 720 ggctcccatc tgacagctgt caccatattc tatgcaactc ttttcttcat gtatctcaga 780 cgcccctcaa aggaatctgt ggaacaggga aaaatggtag ctgtatttta tacaacggta 840 atccccatgc tgaaccccat gatttatagc cttaggaata aagatgtgaa agaagcatta 900 accaaagagt tgttaggaaa caaaaggttt tcttaa 936

<210> 692 <211> 311 <212> PRT <213> Canis familiaris

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<400> 692 Phe Thr Ser Val Thr Glu Phe Ile Leu Leu Gly 15 Leu Met 1 Arg Arg Asn 5 10 Thr Ser Arg Leu Glu Leu Gln Ile Val Leu Phe Leu Leu Phe Leu Ala 20 25 30 Ile Tyr Leu Val Thr Leu Ala Gly Asn Leu Gly Met Ile Val Leu Ile 35 40 45 Gln Val Asn Ala Gln Leu His Lys Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ser Phe Val Asp Leu Cys Phe Ser Ser Asn Val Thr Pro Lys Met 65 70 75 80 Leu Glu Val Phe Leu Ser Glu Lys Lys Thr Ile Ser Tyr Pro Ala Cys 85 90 95 Leu Val Gln Cys Tyr Phe Phe Ile Thr Leu Val His Val Glu Ile Tyr 100 105 110 Ile Leu Ala Val Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Asn Pro 115 120 125 Leu Leu Tyr Gly Ser Lys Met Ser Lys Ser Val Cys Thr Ser Leu Ile 130 135 140 Thr Gly Pro Tyr Val Tyr Gly Ala Leu Thr Gly Leu Met Glu Thr Met 145 150 155 160 Trp Thr Tyr Asn Leu Val Phe Cys Gly Pro Asn Glu Ile Asn His Phe 165 170 175 Tyr Cys Ala Asp Pro Pro Leu Ile Lys Leu Ala Cys Ser Asp Thr Tyr 180 185 190 Asn Lys Glu Leu Ser Met Phe Val Val Ala Gly Cys Asn Leu Ser Phe 195 200 205

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Ser Leu Leu Ile Ile Leu Ile Ser Tyr Leu Tyr Ile Val Pro Ala Ile 210 215 220 Leu Lys Ile Arg Ser Thr Glu Gly Arg His Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Ser His Leu Thr Ala Val Thr Ile Phe Tyr Ala Thr Leu Phe Phe 245 250 255 Met Tyr Leu Arg Arg Pro Ser Lys Glu Ser Val Glu Gln Gly Lys Met 260 265 270 Val Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Thr Lys Glu Leu 290 295 300 Leu Gly Asn Lys Arg Phe Ser

305 310 <210> 693 <211> 933 <212> DNA <213> Canis familiaris <400> 693

atgctcaatt ttactgatgt aacagaattc attcttttgg gattaaccag tcgtcctgaa 60 ctgcaagtcc ttttctttgc ggtgttctta ctggtctaca ctatcacgct ggtcgggaac 120 attggcatga tcattctaat caggatcagt ccccagctca acagtcccat gtacttcttc 180 ctcagccact tatcttttgc cgatgtgtgg ttctcctcta atgtcacacc gaagatgtta 240 gaaaatctgg tggctgagat caaaaccatt tcctacactg gctgtatagt gcagtgtttt 300 ttcttcattg cctttgtcca cgtggaggtg ttcatccttg ccgtaatggc ctttgacaga 360 tacatggcga ttggcaaccc tctgctctac agcagccgaa tgtcaaggac catctgtatt 420 cgactgatct cttttcctta catatatggc ttcttcatta gtctgatctc cacactgtgg 480 acccatggtc tatacttttg tgggaaggta gagatcaacc acttctactg tgcagatcca 540

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gctctcatca aaatggcctg tgcagggacc ttcatcaaag aatacaccat gcgcacattg 600 gcagggctca acttctctta ttctctacta gtcattatca tctcctacat tttcatcctc 660 atcgccatcc taaggatgcg ctcagcagaa ggaagaaaga aagccttttc cacatgtggc 720 tcccacttga cagctgtcac catattctat ggaaccctct tcttcatgta tctcagaagt 780 ccgacagaag agtctgtgga acagggcaag atggtggctg tgttttacac cacagtaatt 840 cctatgttga accccatgat ctacagtctc aggaacaaag atgtaaagga ggccatgagc 900 agagcagtca gtagaacttt tttaactaag taa 933

<210> 694 <211> 310 <212> PRT <213> Canis familiaris <400> 694

Met 1 Leu Asn Phe Thr 5 Asp Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Ser Arg Pro Glu Leu Gln Val Leu Phe Phe Ala Val Phe Leu Leu Val 20 25 30 Tyr Thr Ile Thr Leu Val Gly Asn Ile Gly Met Ile Ile Leu Ile Arg 35 40 45 Ile Ser Pro Gln Leu Asn Ser Pro Met Tyr Phe Phe Leu Ser His Leu 50 55 60 Ser Phe Ala Asp Val Trp Phe Ser Ser Asn Val Thr Pro Lys Met Leu 65 70 75 80 Glu Asn Leu Val Ala Glu Ile Lys Thr Ile Ser Tyr Thr Gly Cys Ile 85 90 95 Val Gln Cys Phe Phe Phe Ile Ala Phe Val His Val Glu Val Phe Ile 100 105 110 Leu Ala Val Met Ala Phe Asp Arg Tyr Met Ala Ile Gly Asn Pro Leu 115 120 125

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Leu Tyr 130 Ser Ser Arg Met Ser Arg Thr Ile Cys Ile Arg Leu Ile Ser 135 140 Phe Pro Tyr Ile Tyr Gly Phe Phe Ile Ser Leu Ile Ser Thr Leu Trp 145 150 155 160 Thr His Gly Leu Tyr Phe Cys Gly Lys Val Glu Ile Asn His Phe Tyr 165 170 175 Cys Ala Asp Pro Ala Leu Ile Lys Met Ala Cys Ala Gly Thr Phe Ile 180 185 190 Lys Glu Tyr Thr Met Arg Thr Leu Ala Gly Leu Asn Phe Ser Tyr Ser 195 200 205 Leu Leu Val Ile Ile Ile Ser Tyr Ile Phe Ile Leu Ile Ala Ile Leu 210 215 220 Arg Met Arg Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Leu Phe Phe Met 245 250 255 Tyr Leu Arg Ser Pro Thr Glu Glu Ser Val Glu Gln Gly Lys Met Val 260 265 270 Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Met Ser Arg Ala Val Ser 290 295 300 Arg Thr Phe Leu Thr Lys

305 310 <210> 695 <211> 933

Page 780

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 695 atgctcaatt tcaccgatgt gacagaattc attctcttgg gactcaccag tcgtcaggaa 60 tggcaagttc tcctctttgc catttttctt gcagtctaca ttgtcacggt ggtgggcaat 120 gttggcatga ttgtgttgat taaggtcagt ccacagctta acagccccat gtactttttt 180 ctcagccatt tgtcatttgt ggatgtgtgg ttttcttcca acgtgacccc caaaatgctg 240 gaaaatctgt tatctgagac aaaaacgatt tcttatgctg gctgtttggt acagtgtttc 300 ttcttcattg cccttgtcca tgtggaaatt ttcattcttg ctgtgatggc ctttgatagg 360 tacatggcaa ttgggaagcc cctgctgtat ggcagcaaaa tgtctagggc tgtgtgtatt 420 cggctgattt ccttccctta cgtatatggt tttctgacta gtctggcagc aaccctgtgg 480 acatatggct tgtccttttg tgggaatatt gagatcaacc acttctactg tgcagaccca 540 cctctcatca aaatggcatg tgctgggacc tttgtaaaag aatacactat gatcatactt 600 gcaggtatta atttcacata ttccctaact gtagtgacca tttcttatct gttcattctc 660 cttgccattc tacggatgca ctcggcgcaa gggaggcgga aggccttttc cacctgtggg 720 tcccacttga cagctgtcgt catattttat gggactctca tattcatgta tctcagacgt 780 cccacagagg agtctgtgga gcaggggaaa atggtggctg tgttttatac cacagtgatt 840 cccatgctga atcccatgat ctacagtctg aggaacaaag atgtgaaaga agccatgagc 900 aaagtgatca gcagaacatg tttaacaaaa taa 933 <210> 696 <211> 310 <212> PRT <213> Canis familiaris <400> 696

Met 1 Leu Asn Phe Thr 5 Asp Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Ser Arg Gln Glu Trp Gln Val Leu Leu Phe Ala Ile Phe Leu Ala Val 20 25 30 Tyr Ile Val Thr Val Val Gly Asn Val Gly Met Ile Val Leu Ile Lys

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Val Ser Pro Gln Leu Asn Ser Pro Met Tyr Phe Phe Leu Ser His Leu 50 55 60 Ser Phe Val Asp Val Trp Phe Ser Ser Asn Val Thr Pro Lys Met Leu 65 70 75 80 Glu Asn Leu Leu Ser Glu Thr Lys Thr Ile Ser Tyr Ala Gly Cys Leu 85 90 95 Val Gln Cys Phe Phe Phe Ile Ala Leu Val His Val Glu Ile Phe Ile 100 105 110 Leu Ala Val Met Ala Phe Asp Arg Tyr Met Ala Ile Gly Lys Pro Leu 115 120 125 Leu Tyr Gly Ser Lys Met Ser Arg Ala Val Cys Ile Arg Leu Ile Ser 130 135 140 Phe Pro Tyr Val Tyr Gly Phe Leu Thr Ser Leu Ala Ala Thr Leu Trp 145 150 155 160 Thr Tyr Gly Leu Ser Phe Cys Gly Asn Ile Glu Ile Asn His Phe Tyr 165 170 175 Cys Ala Asp Pro Pro Leu Ile Lys Met Ala Cys Ala Gly Thr Phe Val 180 185 190 Lys Glu Tyr Thr Met Ile Ile Leu Ala Gly Ile Asn Phe Thr Tyr Ser 195 200 205 Leu Thr Val Val Thr Ile Ser Tyr Leu Phe Ile Leu Leu Ala Ile Leu 210 215 220 Arg Met His Ser Ala Gln Gly Arg Arg Lys Ala Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Ala Val Val Ile Phe Tyr Gly Thr Leu Ile Phe Met

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245 069269_0225_SL.TXT 250 255 Tyr Leu Arg Arg Pro Thr Glu Glu Ser Val Glu Gln Gly Lys Met Val 260 265 270 Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Met Ser Lys Val Ile Ser 290 295 300 Arg Thr Cys Leu Thr Lys

305 310 <210> 697 <211> 930 <212> DNA <213> Canis familiaris <400> 697 atgccaaatt tcacagatgt gacggaattt attcttctgg gcttgaccag tcgtcaggag tttcaagttc tcttttttgt ggtattcctg gtagtttaca tgatcactct gttagggaac attggcatga tctttttgat cagcatcagt cctcagcttc agagccctat gtactttttc ttgagtcatc tgtctttcgt ggatgtgtgg ttctcttcca atgttacccc caaaatgctg gaaaacttgt tatcagggac aaaaaccatt tcctacgtag ggtgtttggt gcagtgctac tttttcattg ccctcgtgca tgtggaggtt tatatcttgg cagtgatggc ttttgatcgc tacatggcca tctgcaaccc tctgctttat ggcagtaaaa tgtccaggac cgtctgtgtt cagcttatct ctgtgcctta tgtctatggg ttctctgtta gtctaatatg tacactatgg acatatggct tgtatttctg tggaaacttt gaaatcaacc atttctactg tgcagaccct cctctcatca agattgcctg tgggggggtc cacatcaaag aatacacgat gattgttatt gctggaatta acttcacata ctctctctct gtggtcctca tctcttacac cctcattgta gtcgctgtgc tacgcatgcg ctccgctgat ggcaggagga aggcattctc cacatgtggg tcccacttga cagctgttac catgttttat gggactctca tattcatgta tctcaggcgt cccactgaag agtctgtgga gcagggaaaa atggtggctg tgttttatac cacagtgatc Page 783

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840

069269_0225_SL.TXT cccatgctga atcccatgat ctacagtctg cggaacaagg atgtgaaaga ggcagtcaac aaagcaattg ccaaagcaaa cttggggtag

900

930 <210> 698 <211> 309 <212> PRT <213> Canis familiaris <400> 698

Met Pro 1 Asn Phe Thr Asp Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 5 10 15 Ser Arg Gln Glu Phe Gln Val Leu Phe Phe Val Val Phe Leu Val Val 20 25 30 Tyr Met Ile Thr Leu Leu Gly Asn Ile Gly Met Ile Phe Leu Ile Ser 35 40 45 Ile Ser Pro Gln Leu Gln Ser Pro Met Tyr Phe Phe Leu Ser His Leu 50 55 60 Ser Phe Val Asp Val Trp Phe Ser Ser Asn Val Thr Pro Lys Met Leu 65 70 75 80 Glu Asn Leu Leu Ser Gly Thr Lys Thr Ile Ser Tyr Val Gly Cys Leu 85 90 95 Val Gln Cys Tyr Phe Phe Ile Ala Leu Val His Val Glu Val Tyr Ile 100 105 110 Leu Ala Val Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Asn Pro Leu 115 120 125 Leu Tyr Gly Ser Lys Met Ser Arg Thr Val Cys Val Gln Leu Ile Ser 130 135 140 Val Pro Tyr Val Tyr Gly Phe Ser Val Ser Leu Ile Cys Thr Leu Trp 145 150 155 160

Page 784

Thr Tyr Gly Leu Tyr 165 Phe Cys Cys Ala Asp Pro 180 Pro Leu Ile Lys Glu Tyr 195 Thr Met Ile Val Leu Ser 210 Val Val Leu Ile Ser 215 Arg 225 Met Arg Ser Ala Asp 230 Gly Ser His Leu Thr Ala 245 Val Thr Tyr Leu Arg Arg 260 Pro Thr Glu Ala Val Phe 275 Tyr Thr Thr Val Ser Leu 290 Arg Asn Lys Asp Val 295 Lys 305 Ala Asn Leu Gly

069269_0225_SL.TXT Gly Asn Phe Glu Ile Asn 170 His Phe 175 Tyr Lys Ile 185 Ala Cys Gly Gly Val 190 His Ile Ile 200 Ala Gly Ile Asn Phe 205 Thr Tyr Ser Tyr Thr Leu Ile Val 220 Val Ala Val Leu Arg Arg Lys Ala 235 Phe Ser Thr Cys Gly 240 Met Phe Tyr 250 Gly Thr Leu Ile Phe 255 Met Glu Ser 265 Val Glu Gln Gly Lys 270 Met Val Ile 280 Pro Met Leu Asn Pro 285 Met Ile Tyr Lys Glu Ala Val Asn 300 Lys Ala Ile Ala

<210> 699 <211> 930 <212> DNA <213> Canis familiaris <400> 699 atgacaagag cacaagtatc ggtaacattg aaaatagcac gatacttcct gaattatcct tgaagtgact cttcattgta actcatcaag gaattttttc ttctgggatt tggtgcccaa tttctggtga tctatgcgac ttccatgatg acagattcca gacttcaaac acctatgtac

120

180

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tttttcctgc aacatttggc ctttgttgat atttgttata cctctgctat cactcccaag 240 atgctgcaaa acttcatatt agaaaataag tctatatcat ttgagggctg tgcaatgcaa 300 ttattggttt atgcaacatt tgcaaccagt gactgctacc tcctggctgc tatggcagtg 360 gaccgttatg tagccatctg taacccactt cactatccca tgatcatgtc ccaaagagtc 420 tgcatccaac tggtagctgg ttcatacatc atgggttcaa taaatgcttc tgtgcacaca 480 ggttttacat tttcactgta cttttgcaaa tctaacacca tcaatcactt tttctgtgat 540 gttcccccaa ttctggccct ttcatgctcc agcattgaca tcaacatcat gctccttgtt 600 gtctttgtgg gatttaactt gatgttcact gtgttagttg tcatctcttc ctatatatat 660 atcatggctg ccatcctgaa gatatcttct gctaccgaga ggaaaaaagc cttctccacg 720 tgctcttccc acctgacagc catcatcatt ttctatacaa ccctatcata catgtactta 780 cagcctcagg ctaataattc tcaggagaat atgaaagtga cttctgtatt ttacggcatt 840 gtgattcctt ttttgaaccc cttgatctat agtttgagaa ataaggaggt aaaagaggct 900 ctaaaagtga tgaggaagaa gttcttctag 930

<210> 700 <211> 309 <212> PRT <213> Canis familiaris <400> 700

Met Thr Arg Glu Asn Ser Thr Glu Val Thr Glu Phe Phe Leu Leu Gly 1 5 10 15 Phe Gly Ala Gln His Lys Tyr Arg Tyr Phe Leu Phe Ile Val Phe Leu 20 25 30 Val Ile Tyr Ala Thr Ser Met Met Gly Asn Ile Gly Ile Ile Leu Leu 35 40 45 Ile Lys Thr Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Gln 50 55 60 His Leu Ala Phe Val Asp Ile Cys Tyr Thr Ser Ala Ile Thr Pro Lys 65 70 75 80

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Met Leu Gln Asn Phe Ile Leu Glu Asn Lys Ser Ile Ser Phe Glu Gly 85 90 95 Cys Ala Met Gln Leu Leu Val Tyr Ala Thr Phe Ala Thr Ser Asp Cys 100 105 110 Tyr Leu Leu Ala Ala Met Ala Val Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu His Tyr Pro Met Ile Met Ser Gln Arg Val Cys Ile Gln Leu 130 135 140 Val Ala Gly Ser Tyr Ile Met Gly Ser Ile Asn Ala Ser Val His Thr 145 150 155 160 Gly Phe Thr Phe Ser Leu Tyr Phe Cys Lys Ser Asn Thr Ile Asn His 165 170 175 Phe Phe Cys Asp Val Pro Pro Ile Leu Ala Leu Ser Cys Ser Ser Ile 180 185 190 Asp Ile Asn Ile Met Leu Leu Val Val Phe Val Gly Phe Asn Leu Met 195 200 205 Phe Thr Val Leu Val Val Ile Ser Ser Tyr Ile Tyr Ile Met Ala Ala 210 215 220 Ile Leu Lys Ile Ser Ser Ala Thr Glu Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Ile Ile Ile Phe Tyr Thr Thr Leu Ser 245 250 255 Tyr Met Tyr Leu Gln Pro Gln Ala Asn Asn Ser Gln Glu Asn Met Lys 260 265 270 Val Thr Ser Val Phe Tyr Gly Ile Val Ile Pro Phe Leu Asn Pro Leu 275 280 285

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Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Lys Val Met 290 295 300

Arg Lys Lys Phe Phe

305 <210> 701 <211> 957 <212> DNA <213> Canis familiaris <400> 701

atggctgaaa ggaatagcac caaggtgaca gaattcattc ttttgggttt ttccgtccac 60 agagagattg aaatcattct ctttctgctc atttcagtgg tctacactct aacattggta 120 gggaacctag ggatgatttc tttaatccga ttggattctc gacttcacac acccatgtac 180 ttttttctca gtaatctggc ctttatagac ctctgttact cctcatcgat agcccccaag 240 ttcctggaga ccctcctgac caagcacagg tctatatctt tctatgcatg tgcaacacag 300 ctgggctttt tcttgaactt cctgatttct gagatgttcc ttcttgcagt aatggcttat 360 gaccgttatg tggccatctg caatcctctt ctctacatga tgatcatgtc tcgaaaggtg 420 tgtatgcagc tggtgatagg cccctactta tacagctttt ctgttgcttt gctccacaca 480 gttgttactt tccaactgat gtattgtggc cccaatatca tcaatcactt ctattgtgac 540 gatgttcctt tgatggcact tgcctgctcg gacaccagcc tcaaagaaat cttgattttc 600 atctttgctg gattcaacat gatcagctct ttgaccactg ttcttatttc ttacttatac 660 attgtggccg ccatcttgaa aatccagtct acagaaggga ggtgcaaagc tttctcgact 720 tgtgcttctc atttgactgc tgtgactata ttctatggga cattgatctt catgtatctg 780 cagccaaaat caaaccactc ccttgacaca gacaaaatgg cctctgtatt ttacacaata 840 gtaattccta tgctaaaccc cattatctat agcttgagga accaagaggt aaaaaatgcc 900 ttaagaaaag caactgacaa gtgttatgtc ctgtttctaa caaacctaaa aaaatga 957

<210> 702 <211> 318 <212> PRT <213> Canis familiaris

Page 788

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<400> 702 Asn Ser Thr Lys Val Thr Glu Phe Ile Leu Leu 15 Gly Met 1 Ala Glu Arg 5 10 Phe Ser Val His Arg Glu Ile Glu Ile Ile Leu Phe Leu Leu Ile Ser 20 25 30 Val Val Tyr Thr Leu Thr Leu Val Gly Asn Leu Gly Met Ile Ser Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ala Phe Ile Asp Leu Cys Tyr Ser Ser Ser Ile Ala Pro Lys 65 70 75 80 Phe Leu Glu Thr Leu Leu Thr Lys His Arg Ser Ile Ser Phe Tyr Ala 85 90 95 Cys Ala Thr Gln Leu Gly Phe Phe Leu Asn Phe Leu Ile Ser Glu Met 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Met Ile Met Ser Arg Lys Val Cys Met Gln Leu 130 135 140 Val Ile Gly Pro Tyr Leu Tyr Ser Phe Ser Val Ala Leu Leu His Thr 145 150 155 160 Val Val Thr Phe Gln Leu Met Tyr Cys Gly Pro Asn Ile Ile Asn His 165 170 175 Phe Tyr Cys Asp Asp Val Pro Leu Met Ala Leu Ala Cys Ser Asp Thr 180 185 190 Ser Leu Lys Glu Ile Leu Ile Phe Ile Phe Ala Gly Phe Asn Met Ile 195 200 205

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Ser Ser Leu Thr Thr Val Leu Ile Ser Tyr Leu Tyr Ile Val Ala Ala 210 215 220 Ile Leu Lys Ile Gln Ser Thr Glu Gly Arg Cys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Met Tyr Leu Gln Pro Lys Ser Asn His Ser Leu Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Val Lys Asn Ala Leu Arg Lys Ala 290 295 300 Thr Asp Lys Cys Tyr Val Leu Phe Leu Thr Asn Leu Lys Lys

305 310 315 <210> 703 <211> 960 <212> DNA <213> Canis familiaris <400> 703

atggctgatg tcaatatcac ctatgtcact gagttcattc tcaagggaat tacagaccgg 60 ccagagctcc aggccccatg ctttgtggtg tttttcatca tctatctggt cacagtggtg 120 ggaaacctgg ggttgataac tttaatcagg attgactctc gactccacac acctatgtac 180 tattttctca gtcacttggc ctttgttgac ctttgctatt cttctgctat cacaccaaag 240 atgatggtga attttgttgt ggaactcaac attattcctt tccatgcttg tgcaacacaa 300 ctgggctgtt ttctcacctt catgatcact gagtgtttcc ttttggcttc tatggcttat 360 gatcgctatg tagctatctg tagtccccta cactattcaa ccctgatgtc aagaagacta 420 tgcattcaat tagtggcagt tccatatata tacagctttc tggttgccct gttccatacc 480

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attatcacct tccgtctaag ttactgtggc cccaatgtaa ttaaccactt ctactgtgat 540 gacctccctc tcttggctct gtcctgctca gacacacaca tgaaggaaat tctgatcttt 600 gcctttgctg gttttgatat gatatgttcc tcttccattg tcctcacctc ctacatcttt 660 atcattgcgg ccattctaag gatccgctct acccaggggc gacgcaaggc catttccacc 720 tgtggctccc atatggtggc tgtcactatt ttttatggaa ccttgatctt tatgtaccta 780 cagcccaaat caaatcactc cttggacaca gacaaaatgg catctgtatt ttacacagtg 840 gtgatcccaa tgttgaaccc cctgatctat agtctaagga acaaagaggt gaaagatgcc 900 tcaaagaaag ccttggataa aggttgtgaa accttaaatc tgttaaaatt aagaaaataa 960

<210> 704 <211> 319 <212> PRT <213> Canis familiaris <400> 704

Met Ala Asp Val Asn Ile Thr Tyr Val Thr Glu Phe Ile Leu Lys Gly 1 5 10 15 Ile Thr Asp Arg Pro Glu Leu Gln Ala Pro Cys Phe Val Val Phe Phe 20 25 30 Ile Ile Tyr Leu Val Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Ile Arg Ile Asp Ser Arg Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 His Leu Ala Phe Val Asp Leu Cys Tyr Ser Ser Ala Ile Thr Pro Lys 65 70 75 80 Met Met Val Asn Phe Val Val Glu Leu Asn Ile Ile Pro Phe His Ala 85 90 95 Cys Ala Thr Gln Leu Gly Cys Phe Leu Thr Phe Met Ile Thr Glu Cys 100 105 110 Phe Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser

Page 791

115 069269_0225_SL.TXT 120 125 Pro Leu His Tyr Ser Thr Leu Met Ser Arg Arg Leu Cys Ile Gln Leu 130 135 140 Val Ala Val Pro Tyr Ile Tyr Ser Phe Leu Val Ala Leu Phe His Thr 145 150 155 160 Ile Ile Thr Phe Arg Leu Ser Tyr Cys Gly Pro Asn Val Ile Asn His 165 170 175 Phe Tyr Cys Asp Asp Leu Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 His Met Lys Glu Ile Leu Ile Phe Ala Phe Ala Gly Phe Asp Met Ile 195 200 205 Cys Ser Ser Ser Ile Val Leu Thr Ser Tyr Ile Phe Ile Ile Ala Ala 210 215 220 Ile Leu Arg Ile Arg Ser Thr Gln Gly Arg Arg Lys Ala Ile Ser Thr 225 230 235 240 Cys Gly Ser His Met Val Ala Val Thr Ile Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Met Tyr Leu Gln Pro Lys Ser Asn His Ser Leu Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Ser Lys Lys Ala 290 295 300 Leu Asp Lys Gly Cys Glu Thr Leu Asn Leu Leu Lys Leu Arg Lys 305 310 315

<210> 705

Page 792

069269_0225_SL.TXT <211> 942 <212> DNA <213> Canis familiaris <400> 705

atggccagag gcaatcattc agtagtatct gagtttatcc tcttggggct cactgataat 60 ccagagcttc aagccattct ctttggtata ttcctagtca tctatttagc tagtgtcatg 120 ggtaatctcg gtatgattgt gctcatccaa gtcagccctc agcttcacac acccatgtac 180 ttttttctca accacctggc ttttgttgat ttttgtttta cttcatctgt caccccaaac 240 accttggtga attttctgtg tgatgtgaaa agtataacat tttatgcatg tgctcttcag 300 gtgtgctgct tcatcacatt tgtagtttgt gaactgtatt tgcttgcagt catggcctat 360 gatcggtatg tggccatctg caaccctcta ctgtacatca ttctcatgcc tagaaagctc 420 tgtaatcaaa tgattgctag cacatatgct tatggattca cagtgggtct catacagaca 480 gtggcaacat tccacttgtc tttttgtggc tccaacgtga tcaatcactt ttattgtgat 540 gatgttccct tggttgctct ggcctgctct gacactcacc tcaaagagct gatgttgttc 600 atcattgctg gattcaatac cctctgctct ctactacttg taataatttc ttatatcttc 660 atcttcttta ccatcctaag gatccattct actgaaggaa gacagaaagc cttttatacg 720 tgtgcttccc acctaacctc catcacaata ttttatggga caatcatttt tatgtatcta 780 ctgcccaagt caagccattc tctgaacaga gataaatttg cttcagtgtt ttatgtggta 840 gtgattccca tgttaaaccc actgatctac agcttgagaa atcaggaggt aaaaaatgca 900 ctgaaaagaa ttatagcaaa gttgtgtttg gctgtcaaat aa 942

<210> 706 <211> 313 <212> PRT <213> Canis familiaris <400> 706

Met Ala Arg Gly Asn His Ser Val Val Ser Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Thr Asp Asn Pro Glu Leu Gln Ala Ile Leu Phe Gly Ile Phe Leu 20 25 30

Page 793

Val Ile Tyr 35 Leu Ala Ser Val 069269_0225_SL.TXT Met Gly Asn Leu Gly Met 40 45 Ile Val Leu Ile Gln Val Ser Pro Gln Leu His Thr Pro Met Tyr Phe Phe Leu Asn 50 55 60 His Leu Ala Phe Val Asp Phe Cys Phe Thr Ser Ser Val Thr Pro Asn 65 70 75 80 Thr Leu Val Asn Phe Leu Cys Asp Val Lys Ser Ile Thr Phe Tyr Ala 85 90 95 Cys Ala Leu Gln Val Cys Cys Phe Ile Thr Phe Val Val Cys Glu Leu 100 105 110 Tyr Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ile Ile Leu Met Pro Arg Lys Leu Cys Asn Gln Met 130 135 140 Ile Ala Ser Thr Tyr Ala Tyr Gly Phe Thr Val Gly Leu Ile Gln Thr 145 150 155 160 Val Ala Thr Phe His Leu Ser Phe Cys Gly Ser Asn Val Ile Asn His 165 170 175 Phe Tyr Cys Asp Asp Val Pro Leu Val Ala Leu Ala Cys Ser Asp Thr 180 185 190 His Leu Lys Glu Leu Met Leu Phe Ile Ile Ala Gly Phe Asn Thr Leu 195 200 205 Cys Ser Leu Leu Leu Val Ile Ile Ser Tyr Ile Phe Ile Phe Phe Thr 210 215 220 Ile Leu Arg Ile His Ser Thr Glu Gly Arg Gln Lys Ala Phe Tyr Thr 225 230 235 240

Page 794

Cys Ala Ser His Leu 245 Thr Ser 069269_0225_SL.TXT Ile Thr Ile Phe Tyr Gly 250 Thr Ile 255 Ile Phe Met Tyr Leu Leu Pro Lys Ser Ser His Ser Leu Asn Arg Asp Lys 260 265 270 Phe Ala Ser Val Phe Tyr Val Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Val Lys Asn Ala Leu Lys Arg Ile 290 295 300 Ile Ala Lys Leu Cys Leu Ala Val Lys

305 310 <210> 707 <211> 942 <212> DNA <213> Canis familiaris <400> 707

atggcaaaag gcaatcactc agcagtcact gagtttattc tcttgggcct cacagataat 60 ccggagattc aggccgttct tttctgtgta ttcctattga tatacttagt tactgtcttg 120 ggtaatcttg gtttgattgt gctcatccaa atcagtcctc aacttcacac ccccatgtat 180 tttttcctct gtcatctggc ttttgttgat ttttatggta cctctgccat cactccaaac 240 acactggtga actctctacg tgaaattaaa agtatgccat tttatgcatg tgccactcaa 300 gtatgttgct ttatcacatt ttcagtttgg gaattactaa tgctctctgt catggcctat 360 gaccggtatg tggccatctg tagccctcta ctctacatca ttctcatgtc caagaaactc 420 tgcatccagt tggtcactag ttcttatatt tatggattca ctgtggggct catacaaaca 480 atggttacat tccacatgtc tttctgtgat tccaatgtgg tcaaccagtt ctactgtgat 540 gatgttccct tgattgctct ggcctgctct gacactcaag tcaaagaatt gatgttgctc 600 atcattgctg ggttcaatgt cttctgctct cttatcattg ttcttatatc ctatgggttc 660 attgtctttg ccatcttaaa gatccattct gctgcaggaa gacaaaaagc cttttccacc 720 tgtgcttctc acctgttttc tattactatg tattatggga ccctcagttt tatgtacctg 780

Page 795

069269_0225_SL.TXT cgccccaagt caagccactc actggataaa gacaaatttg cctcagtatt ctatgcagtg gtgattccca tgctaaaccc gttaatttac agcttgagga atcaggaggt aaaaaatgcc ttcaagaaaa tatttgaaaa ggtatattct agtaatcaat aa

840

900

942 <210> 708 <211> 313 <212> PRT <213> Canis familiaris <400> 708

Met Ala 1 Lys Gly Asn His Ser Ala Val Thr Glu Phe Ile Leu Leu Gly 5 10 15 Leu Thr Asp Asn Pro Glu Ile Gln Ala Val Leu Phe Cys Val Phe Leu 20 25 30 Leu Ile Tyr Leu Val Thr Val Leu Gly Asn Leu Gly Leu Ile Val Leu 35 40 45 Ile Gln Ile Ser Pro Gln Leu His Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60 His Leu Ala Phe Val Asp Phe Tyr Gly Thr Ser Ala Ile Thr Pro Asn 65 70 75 80 Thr Leu Val Asn Ser Leu Arg Glu Ile Lys Ser Met Pro Phe Tyr Ala 85 90 95 Cys Ala Thr Gln Val Cys Cys Phe Ile Thr Phe Ser Val Trp Glu Leu 100 105 110 Leu Met Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr Ile Ile Leu Met Ser Lys Lys Leu Cys Ile Gln Leu 130 135 140 Val Thr Ser Ser Tyr Ile Tyr Gly Phe Thr Val Gly Leu Ile Gln Thr 145 150 155 160

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Met Val Thr Phe His 165 Met Ser Phe Phe Tyr Cys Asp 180 Asp Val Pro Leu Gln Val Lys 195 Glu Leu Met Leu Leu 200 Cys Ser 210 Leu Ile Ile Val Leu 215 Ile Ile 225 Leu Lys Ile His Ser 230 Ala Ala Cys Ala Ser His Leu 245 Phe Ser Ile Phe Met Tyr Leu 260 Arg Pro Lys Ser Phe Ala Ser 275 Val Phe Tyr Ala Val 280 Ile Tyr 290 Ser Leu Arg Asn Gln 295 Glu Phe 305 Glu Lys Val Tyr Ser 310 Ser Asn

Gln

Cys Asp 170 Ser Asn Val Val Asn 175 Gln Ile 185 Ala Leu Ala Cys Ser 190 Asp Thr Ile Ile Ala Gly Phe 205 Asn Val Phe Ser Tyr Gly Phe 220 Ile Val Phe Ala Gly Arg Gln 235 Lys Ala Phe Ser Thr 240 Thr Met 250 Tyr Tyr Gly Thr Leu 255 Ser Ser 265 His Ser Leu Asp Lys 270 Asp Lys Val Ile Pro Met Leu 285 Asn Pro Leu Val Lys Asn Ala 300 Phe Lys Lys Ile

<210> 709 <211> 819 <212> DNA <213> Canis familiaris <400> 709 ttgatctact taattagcgt cacaggtaat tctcagccaa tacccaccta tgtatttttt cttgggttaa ttatgctaat tcatatcaat cctcagcatc ctactttttt tcctggattt

120 ttgctagacc tcttctattt cccctaacac cctggtgaac cgtctccaag aaattaagag Page 797

180

069269_0225_SL.TXT atatccttac ctgcttgtgc cactcacttg tgttacttta tcatgtttgt ggtttatgaa 240 gtgtatttgc tctccatcat ggcatatgat aggtatgtcg ccatttgcaa ccctttcacc 300 actatcatta acagaagggt ctgtattcaa atggtggtta gttcatattt gtatggcttt 360 tctgtgggtt tcctacaggc agtccttaca ttccacttat ctttctgtaa ttcaaatata 420 ataaatcact tctactgtga tgatgttccc ctggttggtc cggggtgctg taaaacccat 480 tacaaagata ccaaagaact agtattgttc acacttactg tttaaatacc ctttgttctc 540 ttattattat ctccatctct tacatattca ttctatttgc cattctgaag attaattcat 600 ctgatggtag gcaaaaagca ttttctactt gtgcctcccc tctgacttcc ttcactatat 660 tttatagcac aatcatcttc atgtatatgc agccaaaaac aagccattct ctagatactg 720 acaagacagc ttctgttttc taatattgta gtaatcccca tgctaaatcc tttaatgtac 780 agcctgagga accaggaagt aaaaaatgtt ttgaaaaga 819 <210> 710 <211> 48 <212> PRT <213> Canis familiaris <400> 710

Leu 1 Ile Tyr Leu Ile Ser Val Thr Gly Asn Leu Gly Leu Ile Met Leu 5 10 15 Ile His Ile Asn Ser Gln Pro Ile Pro Thr Tyr Val Phe Phe Pro Gln 20 25 30 His Pro Thr Phe Phe Pro Gly Phe Leu Leu Asp Leu Phe Tyr Phe Pro 35 40 45

<210> 711 <211> 960 <212> DNA <213> Canis familiaris <400> 711 atggtccaga gaaattgcac ccaagtgaca gaatttattc tcatgggcct cacagatcgt 60 caggagttga agatgcccct ctttgtggct ttcttatcta tctacctctt cacagtagta 120

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ggtaacctgg gtttgatcct agtcattaga acagactcaa gactcaacac accaatgtac 180 ttctttctta gcaacctagc ttttgttgat ttctgttatg cttctgtcat tacacccaaa 240 atgcttggca atttcttgta caaacaaaat gttatctcct tcaatgcatg tgctgctcaa 300 ttaggctgtt tcctggcctt catgactgct gagtgcttgc tactggcatc catggcctat 360 gaccgatacg tggccatttg taaccctctc ctctacatgg ttgtaatgtc cccaggaatc 420 tgcattcagc ttgtagctgt tccctacagc tatagcttcc tggttgcact atttcatacc 480 atcctcactt ttcgcctctc ctattgtcat tccaatatca tcaatcattt ctattgtgat 540 gacatgcctc tccttaggct aacctgttca gacactcact ccaaacagct gtggatcttt 600 gcctgtgctg ggatcatgtt catttcttcc cttttgattg tcttcgtctc ctatacatac 660 attatttctg ccatcctgag gatgcgctca gccgagggca ggcgcaaggc tttctccaca 720 tgtggctctc acatgctggc agtcaccatc ttctatggga ccctcatctt tatgtactta 780 cagccgagct caaaccattc cctagacaca gacaaaatgg cctcagtctt ctacacagtg 840 atcattccca tgttgaaccc tcttatctac agcctcagga ataaggaggt gaaagatgcc 900 ttgaagaaag ttatcatcag tagaaaccag gcttttatgt tcatgaaatt aaagaagtga 960

<210> 712 <211> 319 <212> PRT <213> Canis familiaris <400> 712

Met 1 Val Gln Arg Asn Cys Thr Gln Val Thr Glu Phe Ile Leu Met Gly 5 10 15 Leu Thr Asp Arg Gln Glu Leu Lys Met Pro Leu Phe Val Ala Phe Leu 20 25 30 Ser Ile Tyr Leu Phe Thr Val Val Gly Asn Leu Gly Leu Ile Leu Val 35 40 45 Ile Arg Thr Asp Ser Arg Leu Asn Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ala Phe Val Asp Phe Cys Tyr Ala Ser Val Ile Thr Pro Lys

Page 799

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Met Leu Gly Asn Phe Leu Tyr Lys Gln Asn Val Ile Ser Phe Asn Ala 85 90 95 Cys Ala Ala Gln Leu Gly Cys Phe Leu Ala Phe Met Thr Ala Glu Cys 100 105 110 Leu Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Val Val Met Ser Pro Gly Ile Cys Ile Gln Leu 130 135 140 Val Ala Val Pro Tyr Ser Tyr Ser Phe Leu Val Ala Leu Phe His Thr 145 150 155 160 Ile Leu Thr Phe Arg Leu Ser Tyr Cys His Ser Asn Ile Ile Asn His 165 170 175 Phe Tyr Cys Asp Asp Met Pro Leu Leu Arg Leu Thr Cys Ser Asp Thr 180 185 190 His Ser Lys Gln Leu Trp Ile Phe Ala Cys Ala Gly Ile Met Phe Ile 195 200 205 Ser Ser Leu Leu Ile Val Phe Val Ser Tyr Thr Tyr Ile Ile Ser Ala 210 215 220 Ile Leu Arg Met Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Met Leu Ala Val Thr Ile Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Met Tyr Leu Gln Pro Ser Ser Asn His Ser Leu Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Val Ile Ile Pro Met Leu Asn Pro Leu

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275 Ile Tyr Ser 280 Val Lys Asp Ala 300 285 Leu Lys Lys Val Leu Arg Asn Lys 295 Glu 290 Ile Ile Ser Arg Asn Gln Ala Phe Met Phe Met Lys Leu Lys Lys 305 310 315

<210> 713 <211> 963 <212> DNA <213> Canis familiaris <400> 713

atgcctttaa gagatatggc tcagataaat tgtacccacg tacaggagtt tattctcatg 60 ggcctcacag atcgaaagga gttgaagatg cccttctttg tggttttctt gtctatctac 120 ttcttgacag tagtaggcaa tctaggtttg atcctagtca ttagaacaga ttcaagactt 180 actaacacac cgatgtactt ctttcttagc aacctagctt ttgttgattt ctgttatgct 240 tctgtcatta cacccaaaat gcttggcaat ttcttgtaca aacaaaatgt tatctccttc 300 aatgcatgtg ctgctcagtt aggctgtttc ctcactttca tggtatctga gtgcttgcta 360 ctggcatcca tggcctatga ccgatacgtg gccatttgta accctctcct ctacatggtt 420 gtaatgtccc caggaatccg cattcagctt gtagctgttc cctacagcta tagctttctt 480 atggcactat ttcataccat cctcactttt cgcctctcct attgtcattc caatatcatc 540 aatcatttct attgtgatga catgcctctc cttaggctaa cctgttcaga cactcactcc 600 aaacagctgt ggatcttggc ctgtgctggg atcacattca tttcctctgt tctgattgtc 660 ttcgtctcct atatgtacat tatttctgcc atcctgagga tgcgctcagc tgagggcagg 720 cgcaaggctt tctccacatg tggctctcac atgctggcag tcaccatctt ctatgggacc 780 ctcatcttta tgtacttaca gccgagctca aaccattccc tagacacaga caaaatggcc 840 tcagtcttct acacagtgat cattcccatg ttgaacccct tgatctacag cctcaggaat 900 aaagatgtaa aagatgccct gaaaaaagcc atccttaata gaaaccaagc tttgtgttta 960

tga 963

Page 801

069269_0225_SL.TXT <210> 714 <211> 320 <212> PRT <213> Canis familiaris <400> 714

Met Pro Leu Arg Asp Met Ala Gln Ile Asn Cys Thr His Val Gln Glu 1 5 10 15 Phe Ile Leu Met Gly Leu Thr Asp Arg Lys Glu Leu Lys Met Pro Phe 20 25 30 Phe Val Val Phe Leu Ser Ile Tyr Phe Leu Thr Val Val Gly Asn Leu 35 40 45 Gly Leu Ile Leu Val Ile Arg Thr Asp Ser Arg Leu Thr Asn Thr Pro 50 55 60 Met Tyr Phe Phe Leu Ser Asn Leu Ala Phe Val Asp Phe Cys Tyr Ala 65 70 75 80 Ser Val Ile Thr Pro Lys Met Leu Gly Asn Phe Leu Tyr Lys Gln Asn 85 90 95 Val Ile Ser Phe Asn Ala Cys Ala Ala Gln Leu Gly Cys Phe Leu Thr 100 105 110 Phe Met Val Ser Glu Cys Leu Leu Leu Ala Ser Met Ala Tyr Asp Arg 115 120 125 Tyr Val Ala Ile Cys Asn Pro Leu Leu Tyr Met Val Val Met Ser Pro 130 135 140 Gly Ile Arg Ile Gln Leu Val Ala Val Pro Tyr Ser Tyr Ser Phe Leu 145 150 155 160 Met Ala Leu Phe His Thr Ile Leu Thr Phe Arg Leu Ser Tyr Cys His 165 170 175 Ser Asn Ile Ile Asn His Phe Tyr Cys Asp Asp Met Pro Leu Leu Arg 180 185 190

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Leu Thr Cys 195 Ser Asp Thr His Ser Lys Gln Leu Trp Ile Leu Ala Cys 200 205 Ala Gly Ile Thr Phe Ile Ser Ser Val Leu Ile Val Phe Val Ser Tyr 210 215 220 Met Tyr Ile Ile Ser Ala Ile Leu Arg Met Arg Ser Ala Glu Gly Arg 225 230 235 240 Arg Lys Ala Phe Ser Thr Cys Gly Ser His Met Leu Ala Val Thr Ile 245 250 255 Phe Tyr Gly Thr Leu Ile Phe Met Tyr Leu Gln Pro Ser Ser Asn His 260 265 270 Ser Leu Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr Val Ile Ile 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Asp Ala Leu Lys Lys Ala Ile Leu Asn Arg Asn Gln Ala Leu Cys Leu 305 310 315 320

<210> 715 <211> 930 <212> DNA <213> Canis familiaris <400> 715 atggctcctg gaaatttcac acagatcact gagtttgttc tcgtgggagt ctcagaccgc ccagacctcc agatgccact cttctttgtt ttcctggtga tctatgggct cacggtggca gggaacctgg gcatcatcac cctcaccagt gttgactcgc agcttcaaac gcccatgtac ttcttcctca ggcacttggc tatcatcaat cttggcgatt ctactgtcat ttcccctaag atgctcttca attttttagt aaaagagaaa accactttgt actatgaatg tgccacccaa ctgggaggat tcttggtttt cattgtagct gaggtattca ccttagctgt gatggcctat

120

180

240

300

360

Page 803

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gaccgctatg tggccatttg caaccccctg ctctacatgg tggtggtatc tccacagatt 420 tgccttttct tggtgtccct cacatacctc tacagttttt ccacagcact tgtagtttca 480 tcttgtatat tttctctgtc ttattgctct tccaatgtaa tcaatcattt tttctgtgat 540 attgtccctc tgttaacatt gtcctgctca gatacttacc ttccagagac aatagtattt 600 atatctgcag ctacaaattt ggttttatcc ttgattatag ttctagtatc ctatttcaac 660 attgttttgt ccattctaag gatgcattca tcagaaggaa ggaaaaaagc cttttccaca 720 tgtgcttcac atatgatggc agtcacagtt ttctacggaa cactactatt catgtatttg 780 cagcctcaaa ctaactactc attggatact gataaaattg cttctgtatt ttataccctg 840 gtgatcccca tgttgaatcc catgatctac agcctgcgga ataaggatgt gaaggctgcc 900 ttacagagat ttctgaaaaa ctcatgctga 930

<210> 716 <211> 309 <212> PRT <213> Canis familiaris <400> 716

Met Ala Pro Gly Asn Phe Thr Gln Ile Thr Glu Phe Val Leu Val Gly 1 5 10 15 Val Ser Asp Arg Pro Asp Leu Gln Met Pro Leu Phe Phe Val Phe Leu 20 25 30 Val Ile Tyr Gly Leu Thr Val Ala Gly Asn Leu Gly Ile Ile Thr Leu 35 40 45 Thr Ser Val Asp Ser Gln Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 His Leu Ala Ile Ile Asn Leu Gly Asp Ser Thr Val Ile Ser Pro Lys 65 70 75 80 Met Leu Phe Asn Phe Leu Val Lys Glu Lys Thr Thr Leu Tyr Tyr Glu 85 90 95 Cys Ala Thr Gln Leu Gly Gly Phe Leu Val Phe Ile Val Ala Glu Val

Page 804

100

069269_0225_SL.TXT 105 110

Phe Thr Leu 115 Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 120 125 Pro Leu Leu Tyr Met Val Val Val Ser Pro Gln Ile Cys Leu Phe Leu 130 135 140 Val Ser Leu Thr Tyr Leu Tyr Ser Phe Ser Thr Ala Leu Val Val Ser 145 150 155 160 Ser Cys Ile Phe Ser Leu Ser Tyr Cys Ser Ser Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Val Pro Leu Leu Thr Leu Ser Cys Ser Asp Thr 180 185 190 Tyr Leu Pro Glu Thr Ile Val Phe Ile Ser Ala Ala Thr Asn Leu Val 195 200 205 Leu Ser Leu Ile Ile Val Leu Val Ser Tyr Phe Asn Ile Val Leu Ser 210 215 220 Ile Leu Arg Met His Ser Ser Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Met Met Ala Val Thr Val Phe Tyr Gly Thr Leu Leu 245 250 255 Phe Met Tyr Leu Gln Pro Gln Thr Asn Tyr Ser Leu Asp Thr Asp Lys 260 265 270 Ile Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala Leu Gln Arg Phe 290 295 300 Leu Lys Asn Ser Cys

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305 <210> 717 <211> 960 <212> DNA <213> Canis familiaris <400> 717

atgaaccata tggataaaca gaattatact gcagtgagtg aggtgactga atttattctc 60 atgggaatca ccaaaaaccc tcgacttcaa gcacccctct ttggaatctt cttcatcata 120 tacttggtca cggtgacagg caatctgggc ataattatct tgacccattt ggactccagg 180 ctacagactc cgatgtactt tttccttaga catttgtcaa ttactgatct tggttactct 240 actgtcattg gcccaaaaat gatggtaaat tttgtggtgc acaaaaatac aatctcctac 300 cattggtgtg ccacccagct ggcagtcttt gagattttca tcatcactga actgtttatt 360 ctttcagcaa tggcctatga tcgctatgta gccatctgca aacctctttt gtatgcggtc 420 atcatggcag agaaggtacg ttgggcgctg gtccttgttc cctatctcta cagcatattt 480 gtgtctcttt ttcttacaat taagttattt aaactgtcct tctgtggatc taacattatc 540 agttattttt actgtgactg ccttcctctc atatccctgc tctgttctga cacacatgag 600 ttagaattga tcattttaat tttttcaggc tgtaatttgc tctcttctct cttgattgtt 660 cttgtatcct atatatttat tcttgtggcc attatcagaa tgaactcaac tgaagggaga 720 tacaaagcct tctccacctg tagctcccat ctgacagtgg tgactgtgtt ctatgggaca 780 ttactcttta tttacctgca acccaaatcc agccatacat ttgatattga taaaatggct 840 tctgtgtttt atactctggt gatccctatg ctgaatccat tgatctacag cttaaggaac 900 aaagaagtaa aaggtgctct gaagagaact ttaaccaatg ggtgcaaaat ccccacttag 960

<210> 718 <211> 319 <212> PRT <213> Canis familiaris <400> 718

Met Asn His Met Asp Lys Gln Asn Tyr Thr Ala Val Ser Glu Val Thr 1 5 10 15

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Glu Phe Ile Leu 20 Met Gly Ile Thr Lys Asn Pro Arg Leu Gln Ala Pro 25 30 Leu Phe Gly Ile Phe Phe Ile Ile Tyr Leu Val Thr Val Thr Gly Asn 35 40 45 Leu Gly Ile Ile Ile Leu Thr His Leu Asp Ser Arg Leu Gln Thr Pro 50 55 60 Met Tyr Phe Phe Leu Arg His Leu Ser Ile Thr Asp Leu Gly Tyr Ser 65 70 75 80 Thr Val Ile Gly Pro Lys Met Met Val Asn Phe Val Val His Lys Asn 85 90 95 Thr Ile Ser Tyr His Trp Cys Ala Thr Gln Leu Ala Val Phe Glu Ile 100 105 110 Phe Ile Ile Thr Glu Leu Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg 115 120 125 Tyr Val Ala Ile Cys Lys Pro Leu Leu Tyr Ala Val Ile Met Ala Glu 130 135 140 Lys Val Arg Trp Ala Leu Val Leu Val Pro Tyr Leu Tyr Ser Ile Phe 145 150 155 160 Val Ser Leu Phe Leu Thr Ile Lys Leu Phe Lys Leu Ser Phe Cys Gly 165 170 175 Ser Asn Ile Ile Ser Tyr Phe Tyr Cys Asp Cys Leu Pro Leu Ile Ser 180 185 190 Leu Leu Cys Ser Asp Thr His Glu Leu Glu Leu Ile Ile Leu Ile Phe 195 200 205 Ser Gly Cys Asn Leu Leu Ser Ser Leu Leu Ile Val Leu Val Ser Tyr 210 215 220

Page 807

Ile 225 Phe Ile Leu Val Ala 230 Ile 069269_0225_SL.TXT Ile Arg Met Asn Ser Thr 235 Glu Gly Arg 240 Tyr Lys Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Thr Val 245 250 255 Phe Tyr Gly Thr Leu Leu Phe Ile Tyr Leu Gln Pro Lys Ser Ser His 260 265 270 Thr Phe Asp Ile Asp Lys Met Ala Ser Val Phe Tyr Thr Leu Val Ile 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys 290 295 300 Gly Ala Leu Lys Arg Thr Leu Thr Asn Gly Cys Lys Ile Pro Thr 305 310 315

<210> 719 <211> 945 <212> DNA <213> Canis familiaris <400> 719

atgggtaaac agaacctaac gtcagtgact gagttcattc tgatgggagt cacacggcag 60 cctgagcttc aagttcctct ttttggggtc ttcctcatca tctacatgat cacagtggtg 120 ggaaatttgg gcatgatcac cttgatccag gtggactccc gcctccacac acctatgtat 180 ttttttatca aacacctggc tttcattgac cttggtaatt ctactgtcat ctgtcccaag 240 atgctggtaa attttgttgt ggaccaaaat atcatttctt attatgcatg tgccacacag 300 ttggctttct tccttatgtt cattatcagt gaatttttca tcttgtcagc tatggcctat 360 gaccgctatt tggccatctg taaccctttg ctctacaacg ttattatgtc ccagagactt 420 tgctacatgc tggtgggcat tccatacctc tacagtacct ttcaggctct actgttcact 480 attaagattt tcacactgac cttctgtgga tctaatgtta tcaatcattt ctattgtgat 540 gatgttccct tgttacttat actctgctca aatgcacaag aaataggatt gttgatcata 600 ctattttcag cattgaattt gatctcttct ttcctggtag tcctagtgtc ctacatacta 660

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attctgacat gcatatttca aatccattct acagagagca ggaaaaaagc tttctccaca 720 tgtggttctg atctgacagt ggtagttgta ttctatgggt ctctgctatt tatgtacatg 780 cagcccaaat ctgcccattc ttttgaaact gacaaaatgg cctccgtatt ttacacttta 840 gtgatcccca tgcttaaccc cttaatctac agcctaagga acaaagaggt aaaaaatgct 900 ttccgcaggt tctttttttt tttttttttt ccgcaggttc tttaa 945

<210> 720 <211> 314 <212> PRT <213> Canis familiaris <400> 720

Met Gly Lys Gln 1 Asn 5 Leu Thr Ser Val Thr Glu Phe Ile Leu Met Gly 10 15 Val Thr Arg Gln Pro Glu Leu Gln Val Pro Leu Phe Gly Val Phe Leu 20 25 30 Ile Ile Tyr Met Ile Thr Val Val Gly Asn Leu Gly Met Ile Thr Leu 35 40 45 Ile Gln Val Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Ile Lys 50 55 60 His Leu Ala Phe Ile Asp Leu Gly Asn Ser Thr Val Ile Cys Pro Lys 65 70 75 80 Met Leu Val Asn Phe Val Val Asp Gln Asn Ile Ile Ser Tyr Tyr Ala 85 90 95 Cys Ala Thr Gln Leu Ala Phe Phe Leu Met Phe Ile Ile Ser Glu Phe 100 105 110 Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Ile Met Ser Gln Arg Leu Cys Tyr Met Leu 130 135 140

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Val Gly Ile Pro Tyr Leu Tyr Ser Thr Phe Gln Ala Leu Leu Phe Thr 145 150 155 160 Ile Lys Ile Phe Thr Leu Thr Phe Cys Gly Ser Asn Val Ile Asn His 165 170 175 Phe Tyr Cys Asp Asp Val Pro Leu Leu Leu Ile Leu Cys Ser Asn Ala 180 185 190 Gln Glu Ile Gly Leu Leu Ile Ile Leu Phe Ser Ala Leu Asn Leu Ile 195 200 205 Ser Ser Phe Leu Val Val Leu Val Ser Tyr Ile Leu Ile Leu Thr Cys 210 215 220 Ile Phe Gln Ile His Ser Thr Glu Ser Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser Asp Leu Thr Val Val Val Val Phe Tyr Gly Ser Leu Leu 245 250 255 Phe Met Tyr Met Gln Pro Lys Ser Ala His Ser Phe Glu Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Phe Arg Arg Phe 290 295 300 Phe Phe Phe Phe Phe Phe Pro Gln Val Leu 305 310

<210> 721 <211> 951 <212> DNA <213> Canis familiaris <400> 721 atggaagaga agaatcagac aggagtgact gaatttcttt tcttgggcct cacagatcat Page 810

069269_0225_SL.TXT

ctccaccaac agattgtcct ctttgtcatg cttctcttcg tctatcttgt caccctgggg 120 ggtaacatag ggatgatcat tctcatatgg actgatccca gattccacac gcctatgtac 180 ttttttctca gccacttgtc ctttgttgat ctctgttcct cttcttccat tgcccccaag 240 atgctgtgtg atatctttgc agagaaaaaa gacatctctt tcatgggttg tgctgcacag 300 atgtggttct ttggcctttt tgtggcaact gaatgttttc tcctggcttc catggcatat 360 gatcggtata tggccatctg taagcccttg ctgtatacac tcattatgtc ccagagggtc 420 tgtgtgcagc tggtggtagg gccttattcc atggctctta taagcacaat gactcataca 480 attctcacat ttcgcttacc cttctgtggt ccaaatgtca tcaatcactt cttctgtgac 540 atttctccac tgctttccct agcatgtgca gacacctgga tcaataaatt agtgttgttc 600 atcatggcag gatctatagg aatgctcagt ggcctgatca tcatggtctc ctatgtttgt 660 atcctggtgg ccatcttgaa gatccagact gctgatggaa ggcagaaagc tttctctacc 720 tgctcttctc acctggctgt tgtctctgtg ctgtatggga cacttttctt tatctatgtt 780 cagcctggct ccagtccctc cctggatatc aataaagtga tttctctatt ttatactgtg 840 gtaatcccca tgttgaaccc cctcatctac agtctgagga acaaggaggt gaaaaatgca 900 ttcaggaaga agtttgaaat gaaaaattcc ataatggctt tggcaaaata a 951

<210> 722 <211> 316 <212> PRT <213> Canis familiaris <400> 722

Met Glu Glu Lys Asn Gln Thr Gly Val Thr Glu Phe Leu Phe Leu Gly 1 5 10 15 Leu Thr Asp His Leu His Gln Gln Ile Val Leu Phe Val Met Leu Leu 20 25 30 Phe Val Tyr Leu Val Thr Leu Gly Gly Asn Ile Gly Met Ile Ile Leu 35 40 45 Ile Trp Thr Asp Pro Arg Phe His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60

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His 65 Leu Ser Phe Val Asp Leu Cys Ser Ser Ser Ser Ile Ala Pro Lys 70 75 80 Met Leu Cys Asp Ile Phe Ala Glu Lys Lys Asp Ile Ser Phe Met Gly 85 90 95 Cys Ala Ala Gln Met Trp Phe Phe Gly Leu Phe Val Ala Thr Glu Cys 100 105 110 Phe Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Thr Leu Ile Met Ser Gln Arg Val Cys Val Gln Leu 130 135 140 Val Val Gly Pro Tyr Ser Met Ala Leu Ile Ser Thr Met Thr His Thr 145 150 155 160 Ile Leu Thr Phe Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Leu Leu Ser Leu Ala Cys Ala Asp Thr 180 185 190 Trp Ile Asn Lys Leu Val Leu Phe Ile Met Ala Gly Ser Ile Gly Met 195 200 205 Leu Ser Gly Leu Ile Ile Met Val Ser Tyr Val Cys Ile Leu Val Ala 210 215 220 Ile Leu Lys Ile Gln Thr Ala Asp Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ala Val Val Ser Val Leu Tyr Gly Thr Leu Phe 245 250 255 Phe Ile Tyr Val Gln Pro Gly Ser Ser Pro Ser Leu Asp Ile Asn Lys 260 265 270

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Val Ile Ser Leu Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Phe Arg Lys Lys 290 295 300 Phe Glu Met Lys Asn Ser Ile Met Ala Leu Ala Lys 305 310 315

<210> 723 <211> 939 <212> DNA <213> Canis familiaris <400> 723

atggccaaag agaatttcac agctgttact gaatttattc ttttgggact gacagaccac 60 cctgacctga aaatcatact ttttgtgttg ttcttggtga tttatgcgat taccttgctg 120 gggaatctgg gtatgatctt cataatccaa ataactccca agctccacac acccatgtat 180 tttttcctca gctgcctttc atttgtggat gcctgctatt catctgttat tgcaccgaaa 240 atgctgatca gcttcttggt tgtgaaggaa accatctcat tctctgcctg cattgtgcaa 300 catttgtttt ttggggtgtt tattaccaca gaaggcttct tgttgtcagt gatggcatat 360 gaccgttatg tggccattgt caactctttg ctttacagtg cagccatgtc taagaggaag 420 tgtgtagggt gggtcaatgg atcttggata tgtggaataa ttaactcatt aatacacaca 480 ataagcttag gcagactgtc cttctgtggg tccaatgttg ttaaccactt cttctgtgat 540 attccctcac tcctaaagct atcatgttct gatactacca tgaatgaatt gttgctctta 600 actttctctg gagtcattgc catggccacc ttcttgattg tgatcatttc ctacgtgttt 660 attgctgttg ctattctgag gatccgctca gcagcaggcg gacagaaagc cttctccacg 720 tgtgcctccc acctgactgt tgtgaccata ttctatggta ctttaagctt tagctacatc 780 cagccaagtt cccagtattc tgtggagcag gagaaggtgg tgtctgtgtt ctatacacta 840 gtgattccca tgttaaaccc acttatttac agtctgagga acaaagaggt aaaggatgct 900 gtcaaaaggg ccatcgaaat gacacatttc ccttgttaa 939

Page 813

069269_0225_SL.TXT <210> 724 <211> 312 <212> PRT <213> Canis familiaris <400> 724

Met 1 Ala Lys Glu Asn Phe Thr Ala Val Thr Glu Phe Ile Leu Leu Gly 5 10 15 Leu Thr Asp His Pro Asp Leu Lys Ile Ile Leu Phe Val Leu Phe Leu 20 25 30 Val Ile Tyr Ala Ile Thr Leu Leu Gly Asn Leu Gly Met Ile Phe Ile 35 40 45 Ile Gln Ile Thr Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Cys Leu Ser Phe Val Asp Ala Cys Tyr Ser Ser Val Ile Ala Pro Lys 65 70 75 80 Met Leu Ile Ser Phe Leu Val Val Lys Glu Thr Ile Ser Phe Ser Ala 85 90 95 Cys Ile Val Gln His Leu Phe Phe Gly Val Phe Ile Thr Thr Glu Gly 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Val Asn 115 120 125 Ser Leu Leu Tyr Ser Ala Ala Met Ser Lys Arg Lys Cys Val Gly Trp 130 135 140 Val Asn Gly Ser Trp Ile Cys Gly Ile Ile Asn Ser Leu Ile His Thr 145 150 155 160 Ile Ser Leu Gly Arg Leu Ser Phe Cys Gly Ser Asn Val Val Asn His 165 170 175 Phe Phe Cys Asp Ile Pro Ser Leu Leu Lys Leu Ser Cys Ser Asp Thr

Page 814

180

069269_0225_SL.TXT 185 190

Thr Met Asn Glu Leu Leu Leu Leu Thr Phe Ser Gly Val Ile Ala Met 195 200 205

Ala Thr Phe Leu Ile Val Ile Ile Ser Tyr Val Phe Ile Ala Val Ala 210 215 220

Ile Leu Arg Ile Arg Ser Ala Ala Gly Gly Gln Lys Ala Phe Ser Thr 225 230 235 240

Cys Ala Ser His Leu Thr Val Val Thr Ile Phe Tyr Gly Thr Leu Ser 245 250 255

Phe Ser Tyr Ile Gln Pro Ser Ser Gln Tyr Ser Val Glu Gln Glu Lys 260 265 270

Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285

Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Val Lys Arg Ala 290 295 300

Ile Glu Met Thr His Phe Pro Cys 305 310 <210> 725 <211> 957 <212> DNA <213> Canis familiaris <400> 725

atgagaagaa acaaacaaat ggctgaagag aattatacaa ctgttactga atttattctt 60 ttgggactga cggacctcac tgacctgaaa attatacttt ttgtgttatt cttggtgatt 120 tatgccatta ccttactggg aaatatggtt atgatcttca taatccaaat aactcccaag 180 ctccacacac ccatgtacct tttcctcagc tgcctttcat ttgtagatgc ctgctattca 240 tctgcaattg caccaaaaat gttggtcaac cttctagttg tgaagggaac cattactttc 300 tctgcctgta tggtacaaca tttgtgtttt ggggtgtttg ttaccacaga aggcttcttg 360

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ttgtcagtga tggcatatga ccgttatgtg gccattgtca actctttgct ttacagtgca 420 gccatgtcta agaggaagtg tgtagggtgg gtcaatggat cttggatatg tggaataatt 480 aactcattaa tacacacaat aagcttaggc agactgtcct tctgtgggtc caatgttgtt 540 aaccacttct tctgtgatat tccctcactc ctaaagctat catgttctga tactaccatg 600 aatgaattgt tgctcttaac tttctctgga gtcattgcca tggccacctt cttgattgtg 660 atcatttcct acgtgtttat tgctgttgct attctgagga tccgctcagc agcaggcaga 720 cagaaagcct tctccacgtg tgcctcccac ctgactgctg tgaccatatt ctatggtact 780 ttaagcttta gctacatcca gccaagttcc cagtattttg tggagcagga gaaggtggtg 840 tctgtgttct atacactagt gattcccatg ttaaacccac ttatttacag tctgaggaac 900 aaagaggtaa aggatgctgt caaaagggcc atcgaaatga cacatttccc ttgttaa 957

<210> 726 <211> 318 <212> PRT <213> Canis familiaris <400> 726

Met Arg Arg Asn Lys Gln Met Ala Glu Glu Asn Tyr Thr Thr Val Thr 1 5 10 15 Glu Phe Ile Leu Leu Gly Leu Thr Asp Leu Thr Asp Leu Lys Ile Ile 20 25 30 Leu Phe Val Leu Phe Leu Val Ile Tyr Ala Ile Thr Leu Leu Gly Asn 35 40 45 Met Val Met Ile Phe Ile Ile Gln Ile Thr Pro Lys Leu His Thr Pro 50 55 60 Met Tyr Leu Phe Leu Ser Cys Leu Ser Phe Val Asp Ala Cys Tyr Ser 65 70 75 80 Ser Ala Ile Ala Pro Lys Met Leu Val Asn Leu Leu Val Val Lys Gly 85 90 95

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Thr Ile Thr Phe Ser Ala 100 Cys Met Val 105 Gln His Leu Cys Phe Gly Val 110 Phe Val Thr Thr Glu Gly Phe Leu Leu Ser Val Met Ala Tyr Asp Arg 115 120 125 Tyr Val Ala Ile Val Asn Ser Leu Leu Tyr Ser Ala Ala Met Ser Lys 130 135 140 Arg Lys Cys Val Gly Trp Val Asn Gly Ser Trp Ile Cys Gly Ile Ile 145 150 155 160 Asn Ser Leu Ile His Thr Ile Ser Leu Gly Arg Leu Ser Phe Cys Gly 165 170 175 Ser Asn Val Val Asn His Phe Phe Cys Asp Ile Pro Ser Leu Leu Lys 180 185 190 Leu Ser Cys Ser Asp Thr Thr Met Asn Glu Leu Leu Leu Leu Thr Phe 195 200 205 Ser Gly Val Ile Ala Met Ala Thr Phe Leu Ile Val Ile Ile Ser Tyr 210 215 220 Val Phe Ile Ala Val Ala Ile Leu Arg Ile Arg Ser Ala Ala Gly Arg 225 230 235 240 Gln Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Ala Val Thr Ile 245 250 255 Phe Tyr Gly Thr Leu Ser Phe Ser Tyr Ile Gln Pro Ser Ser Gln Tyr 260 265 270 Phe Val Glu Gln Glu Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys 290 295 300

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Asp Ala Val Lys Arg Ala Ile Glu Met Thr His Phe Pro Cys 305 310 315 <210> 727 <211> 942 <212> DNA <213> Canis familiaris <400> 727

atggaaactc aaaatctaac agtgctcaat gagttcattc tcatgggaat cacagacaaa 60 cctgagctgc aggctccact atttgggctc ttcctcatca tctatttgat ctcagtggtg 120 ggcaacctgg gcatgattgt cctcaccaag gtggacgcca gactacaaac acccatgtat 180 ttcttcctca gacacctggc cttcactgat ctgggttatt caacaactat aggaccaaaa 240 atgttagtaa gttttttttt ggaagaaaac acaatttctt attatttatg tgccacacag 300 ggagctttct acatgatctt catcattagt gaacttttta ttctaactgc tatgtcctac 360 gaccgctaca tggccatctg taaccctctg ctctaccccg tcatcatgtc acagaaggtg 420 tgtcaggtgc tggtggcaat cccttatctc tacagcacat ttgtgtctct tatagtcacc 480 ataaagattt ttagttcatt cttctgtggc tacaatgttg tcaatcattt ctactgtgac 540 tgtctcccct tgttatcttt gctctgctca aatacacatg aaactgaaat gattattctt 600 atcttagctg gttttgattt gatttcatcc cttctggtag ttcttgtgtc ttacctactg 660 atcctagtag ccatcatcaa gatgaactca gctgagggta ggctcaaggc tttttccacc 720 tgtggttccc acctgacagt ggccacagtg ttctatggga ctttgatatt tatgtatgtg 780 caacctgagt ccagtcattc ctttgacact gataaagtgg cgtccatatt ttacaccctc 840 gttatcccca tgctgaatcc cttgatctat agcttgagga acaaagatgt aaaatatgca 900 agacaaagga tgtggaaaaa aatatgtaat atcttttctt aa 942

<210> 728 <211> 313 <212> PRT <213> Canis familiaris <400> 728

Met Glu Thr Gln Asn Leu Thr Val Leu Asn Glu Phe Ile Leu Met Gly 1 5 10 15

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Ile Thr Asp Lys 20 Pro Glu Leu Gln Ala Pro Leu Phe Gly Leu Phe Leu 25 30 Ile Ile Tyr Leu Ile Ser Val Val Gly Asn Leu Gly Met Ile Val Leu 35 40 45 Thr Lys Val Asp Ala Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 His Leu Ala Phe Thr Asp Leu Gly Tyr Ser Thr Thr Ile Gly Pro Lys 65 70 75 80 Met Leu Val Ser Phe Phe Leu Glu Glu Asn Thr Ile Ser Tyr Tyr Leu 85 90 95 Cys Ala Thr Gln Gly Ala Phe Tyr Met Ile Phe Ile Ile Ser Glu Leu 100 105 110 Phe Ile Leu Thr Ala Met Ser Tyr Asp Arg Tyr Met Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Pro Val Ile Met Ser Gln Lys Val Cys Gln Val Leu 130 135 140 Val Ala Ile Pro Tyr Leu Tyr Ser Thr Phe Val Ser Leu Ile Val Thr 145 150 155 160 Ile Lys Ile Phe Ser Ser Phe Phe Cys Gly Tyr Asn Val Val Asn His 165 170 175 Phe Tyr Cys Asp Cys Leu Pro Leu Leu Ser Leu Leu Cys Ser Asn Thr 180 185 190 His Glu Thr Glu Met Ile Ile Leu Ile Leu Ala Gly Phe Asp Leu Ile 195 200 205 Ser Ser Leu Leu Val Val Leu Val Ser Tyr Leu Leu Ile Leu Val Ala 210 215 220

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Ile Ile 225 Lys Met Asn Ser Ala Glu Gly Arg Leu Lys Ala Phe Ser Thr 230 235 240 Cys Gly Ser His Leu Thr Val Ala Thr Val Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Met Tyr Val Gln Pro Glu Ser Ser His Ser Phe Asp Thr Asp Lys 260 265 270 Val Ala Ser Ile Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Tyr Ala Arg Gln Arg Met 290 295 300 Trp Lys Lys Ile Cys Asn Ile Phe Ser

305 310 <210> 729 <211> 942 <212> DNA <213> Canis familiaris <400> 729

atggaaaaac acaatctgac catgctcaat gaattcattc tcatgggaat cacacatcgt 60 cctgagctgc aggctccatt atttgggctc ttctttatca tctatttgat ctccgtggtg 120 ggcaacctgg gcatgatcat cctcaccaaa gtggatgcca gactacaaac acccatgtac 180 ttcttcctca aacacctggc ttttactgac cttggttatt caacaaccgt gggacccaaa 240 atgttagtaa attttattgt ggatcaaaat acaatctcct attatttttg tgctatgcaa 300 ctagctttct ttcttgtgtt tatcataagt gaacttttca ttctaacagc tatgtcctac 360 gaccgttacg tggccatctg caaccctctg ctctaccccg tcatcatgtc acagagggtg 420 tgtcaggtgc tggtggcaat cccttatctc tacagcacat ttgtgtctct tctagtcacc 480 ataaagattt ttagttcatt cttctgtggc tacaatgttg tcaatcattt ctactgtgac 540 tgtctcccct tgttatcttt gctctgctca aattcacatg aaactgaaat gattattctt 600 atcttagctg gttttgattt gatttcatcc cttctggtag ttcttgtgtc ttacctactc 660

Page 820

069269_0225_SL.TXT atcctagtag ccatcatcag gatgagctca gctgagggta ggctcaaggc tttttccacc 720 tgtggttccc acctgacagt ggccacagtg ttctatggga ctttgatatt tatgtatgtg 780 caacctgagt ccagccattc ctttgacact gataaagtgg cgtccatatt ttacaccctc 840 gttatcccca tgctgaatcc cttgatctat agcttgagga acaaagatgt aaaatatgca 900 gtgcaaacaa tgtggaaaaa actatgcaat aatttttctt aa 942 <210> 730 <211> 313 <212> PRT <213> Canis familiaris <400> 730

Met Glu 1 Lys His Asn 5 Leu Thr Met Leu Asn Glu Phe Ile Leu Met Gly 10 15 Ile Thr His Arg Pro Glu Leu Gln Ala Pro Leu Phe Gly Leu Phe Phe 20 25 30 Ile Ile Tyr Leu Ile Ser Val Val Gly Asn Leu Gly Met Ile Ile Leu 35 40 45 Thr Lys Val Asp Ala Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Lys 50 55 60 His Leu Ala Phe Thr Asp Leu Gly Tyr Ser Thr Thr Val Gly Pro Lys 65 70 75 80 Met Leu Val Asn Phe Ile Val Asp Gln Asn Thr Ile Ser Tyr Tyr Phe 85 90 95 Cys Ala Met Gln Leu Ala Phe Phe Leu Val Phe Ile Ile Ser Glu Leu 100 105 110 Phe Ile Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125

Pro Leu Leu Tyr Pro Val Ile Met 130 135

Ser Gln Arg Val 140

Cys Gln Val Leu

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Val Ala Ile Pro Tyr Leu Tyr Ser Thr Phe Val Ser Leu Leu 155 Val Thr 160 145 150 Ile Lys Ile Phe Ser Ser Phe Phe Cys Gly Tyr Asn Val Val Asn His 165 170 175 Phe Tyr Cys Asp Cys Leu Pro Leu Leu Ser Leu Leu Cys Ser Asn Ser 180 185 190 His Glu Thr Glu Met Ile Ile Leu Ile Leu Ala Gly Phe Asp Leu Ile 195 200 205 Ser Ser Leu Leu Val Val Leu Val Ser Tyr Leu Leu Ile Leu Val Ala 210 215 220 Ile Ile Arg Met Ser Ser Ala Glu Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Ala Thr Val Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Met Tyr Val Gln Pro Glu Ser Ser His Ser Phe Asp Thr Asp Lys 260 265 270 Val Ala Ser Ile Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Tyr Ala Val Gln Thr Met 290 295 300 Trp Lys Lys Leu Cys Asn Asn Phe Ser 305 310

<210> 731 <211> 942 <212> DNA <213> Canis familiaris <400> 731

Page 822

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atggcaaaac acaatctaac ggtgctcaat gagttcattc tcatgggaat cacagacaaa 60 cctgagctgc aggctccact atttgggctc ttcctcatca tctatttgat ctcagtggtg 120 ggcaacctgg gcatgatcgt cctcaccaag gtggacgcca gactacaaac acccatgtac 180 ttcttcctca gacacctggc cttcactgat ctgggttatt caacaactat aggaccaaaa 240 atgttagtaa gttttttttt ggaagaaaac acaatttctt attatttatg tgccacacag 300 ggagctttct acatgatctt catcattagt gaacttttta ttctaactgc tatgtcctac 360 gaccgctaca tggccatctg taaccctctg ctctaccccg tcatcatgtc acagaaggtg 420 tgtcaggtgc tggtggcaat cccttatctc tatagcatat ttgtttcact ttttgtcacc 480 gtaaagatct ttagttcatt cttctgtggc tacaatgttg tcaatcattt ctactgtgac 540 tgtctcccct tgttatcttt gctctgctca aatacacatg aaattgaatt gatgattttg 600 attttctcag tttttgatgt cagttcatcc cttctgatag ttcttgtgtc ttacctgctg 660 atcctggtag ccatcgtcag gatgaattca gctgagggta ggctcaaggc tttttccacc 720 tgtgggtccc acctgacagt ggccacagtg ttctatggga ctttgatatt tatgtatgtg 780 caacctgagt ccagccattc ctttgacact gataaagtgg cgtccatatt ttacaccctt 840 ataatcccca tgctgaatcc cttgatctat agcttgagga acaaagatgt aaagtatgct 900 ctacatagga tatggaaaaa aatatgcaat accttttctt aa 942

<210> 732 <211> 313 <212> PRT <213> Canis familiaris <400> 732

Met 1 Ala Lys His Asn Leu Thr Val Leu Asn Glu Phe Ile Leu Met Gly 5 10 15 Ile Thr Asp Lys Pro Glu Leu Gln Ala Pro Leu Phe Gly Leu Phe Leu 20 25 30 Ile Ile Tyr Leu Ile Ser Val Val Gly Asn Leu Gly Met Ile Val Leu 35 40 45 Thr Lys Val Asp Ala Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg

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50 55 60

His 65 Leu Ala Phe Thr Asp Leu Gly Tyr Ser Thr Thr Ile Gly Pro Lys 70 75 80 Met Leu Val Ser Phe Phe Leu Glu Glu Asn Thr Ile Ser Tyr Tyr Leu 85 90 95 Cys Ala Thr Gln Gly Ala Phe Tyr Met Ile Phe Ile Ile Ser Glu Leu 100 105 110 Phe Ile Leu Thr Ala Met Ser Tyr Asp Arg Tyr Met Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Pro Val Ile Met Ser Gln Lys Val Cys Gln Val Leu 130 135 140 Val Ala Ile Pro Tyr Leu Tyr Ser Ile Phe Val Ser Leu Phe Val Thr 145 150 155 160 Val Lys Ile Phe Ser Ser Phe Phe Cys Gly Tyr Asn Val Val Asn His 165 170 175 Phe Tyr Cys Asp Cys Leu Pro Leu Leu Ser Leu Leu Cys Ser Asn Thr 180 185 190 His Glu Ile Glu Leu Met Ile Leu Ile Phe Ser Val Phe Asp Val Ser 195 200 205 Ser Ser Leu Leu Ile Val Leu Val Ser Tyr Leu Leu Ile Leu Val Ala 210 215 220 Ile Val Arg Met Asn Ser Ala Glu Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Ala Thr Val Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Met Tyr Val Gln Pro Glu Ser Ser His Ser Phe Asp Thr Asp Lys

Page 824

260

069269_0225_SL.TXT 265 270

Val Ala Ser Ile Phe Tyr Thr Leu Ile Ile Pro Met Leu Asn Pro Leu 275 280 285

Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Tyr Ala Leu His Arg Ile 290 295 300

Trp Lys Lys Ile Cys Asn Thr Phe Ser 305 310 <210> 733 <211> 351 <212> DNA <213> Canis familiaris <400> 733 tgtgatagtc tatcattgat agctttgctc tgctcaggca cacatgaaat taagttgata 60 attctgatct tttcagcttt taatttagtg tcatctctta tgatagccct gtgttttaca 120 tgctgatcct tattgccatc ctcaggatga actttgcaga aggtaggcac aaggctttct 180 ccacctgtga atcccatatg acactgatag tcatatttta cggttctcca tttttttatg 240 tatgtgcagc ccaaaccaat tcattcattt gatagtgata aaatagcctc cttattttac 300 actttgatta tattcatgct gaatcccatg atctacagtt tgaggaaaaa a 351 <210> 734 <211> 66 <212> PRT <213> Canis familiaris <220>

<221> MOD_RES <222> (66)..(66) <223> Any amino acid

<400> 734 Met Gly Phe Thr Gly Gly Glu Ser Leu Val Pro Thr Phe Cys Lys Val 1 5 10 15

His Pro Glu Asp Gly Asn Lys Asp Gln His Val Lys His Arg Ala Ile 20 25 30

Page 825

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Ile Arg Asp Asp Thr Lys Leu Lys Ala Glu Lys Ile Arg Ile Ile Asn 35 40 45

Leu Ile Ser Cys Val Pro Glu Gln Ser Lys Ala Ile Asn Asp Arg Leu 50 55 60

Ser Xaa 65 <210> 735 <211> 510 <212> DNA <213> Canis familiaris <400> 735

atggagaaac acaatctaac acagtggaaa gaacacatcc aaatgggaat cacagaactc 60 cctgagctgc aggctccatt gtctggactc ttcctcactg tttacctggt gtcactggtg 120 gataacctga gcttgatcat cctcaccaag gtggactcta ggccacaaac acccatgtac 180 atcttcctca gacacctagc tttcactaat attggttgtt caatagctgt gggaccccaa 240 atgctagtaa gccttgttgt agatcaatct atcatctctt ctaactgatg tgctacccaa 300 ctcacttttt tcattatgtt tattactagt gaaattctca ttttgtcagc aatggcctat 360 gactgctatg tggccatcta taatcctctg ctctgcatag tcattatgtc acatagatta 420 tgtcagttgc tggtggcata atctatcatt ttgtctttgc tgatcattat aaaaatttcc 480 ctttcatagt ttggtgacta taatgtcatt 510

<210> 736 <211> 95 <212> PRT <213> Canis familiaris <400> 736

Met Glu Lys His Asn Leu Thr Gln Trp Lys Glu His Ile Gln Met Gly 1 5 10 15

Ile Thr Glu Leu Pro Glu Leu Gln Ala Pro Leu Ser Gly Leu Phe Leu 20 25 30

Page 826

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Thr Val Tyr Leu Val Ser Leu Val Asp Asn Leu Ser Leu Ile Ile Leu 35 40 45 Thr Lys Val Asp Ser Arg Pro Gln Thr Pro Met Tyr Ile Phe Leu Arg 50 55 60 His Leu Ala Phe Thr Asn Ile Gly Cys Ser Ile Ala Val Gly Pro Gln 65 70 75 80 Met Leu Val Ser Leu Val Val Asp Gln Ser Ile Ile Ser Ser Asn 85 90 95

<210> 737 <211> 852 <212> DNA <213> Canis familiaris <400> 737 atgacctgga tgaacagaca aaatctaaca gtgttaacag aattcatcct aatgggaatc 60 accgaccgtc ctgagctgca ggctcccttc tttgggcttt tcctcatcat ctactcagtt 120 tcagtggtgg gcaacctggg catgatcatc ctcaccaagg tggactccag gctccaaaca 180 cccatgtact tcttcctcag acacctggct ttcattgatc ttggctactc atcagctgtg 240 gcacccaaaa tgttagtaaa ttttgtagct gatcaaaata ccatccccta taactggtgt 300 gctacccagc tggctttctt catcttgttc atcatcagtg agctgttcat tctgtcagca 360 atggcctatg accgctatgt ggccatctgt aaccctctgc tctacaccat tgttatgtca 420 caaagggtgt gctgggtgct agtagcaatc ccttatgtct acagtgcctt tctttctctg 480 ataaccacca tcaagatttt tatgtcatcc ttctgtggac ataatgtcat tagacatttt 540 tactgtgata gtcttccctt gttaactttg ctgtgttcaa gcacacgtga cattgagttg 600 ataatactga tcttttcagc atttaatttg atttcctccc ttctcatagt gcttgtgtcc 660 tacatcctac tcatggaggc catcatgtac gtgcaaccca aatccagtca ttcctttgat 720 actgataaaa tcgcctctgc attttacact ttgataatcc ctatgctgaa tcccatgatc 780 tacagcttaa ggaacaaaga ggtaaaaggt gccctgcata gagtatggaa aaacttgcac 840 atactgccta tg 852

Page 827

069269_0225_SL.TXT <210> 738 <211> 284 <212> PRT <213> Canis familiaris <400> 738

Met 1 Thr Trp Met Asn 5 Arg Gln Asn Leu Thr Val Leu Thr Glu Phe Ile 10 15 Leu Met Gly Ile Thr Asp Arg Pro Glu Leu Gln Ala Pro Phe Phe Gly 20 25 30 Leu Phe Leu Ile Ile Tyr Ser Val Ser Val Val Gly Asn Leu Gly Met 35 40 45 Ile Ile Leu Thr Lys Val Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe 50 55 60 Phe Leu Arg His Leu Ala Phe Ile Asp Leu Gly Tyr Ser Ser Ala Val 65 70 75 80 Ala Pro Lys Met Leu Val Asn Phe Val Ala Asp Gln Asn Thr Ile Pro 85 90 95 Tyr Asn Trp Cys Ala Thr Gln Leu Ala Phe Phe Ile Leu Phe Ile Ile 100 105 110 Ser Glu Leu Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Thr Ile Val Met Ser Gln Arg Val Cys 130 135 140 Trp Val Leu Val Ala Ile Pro Tyr Val Tyr Ser Ala Phe Leu Ser Leu 145 150 155 160 Ile Thr Thr Ile Lys Ile Phe Met Ser Ser Phe Cys Gly His Asn Val 165 170 175

Page 828

Ile Arg His Phe 180 Tyr Cys Asp 069269_0225_SL.TXT Ser Leu Pro Leu Leu Thr 185 Leu 190 Leu Cys Ser Ser Thr Arg Asp Ile Glu Leu Ile Ile Leu Ile Phe Ser Ala Phe 195 200 205 Asn Leu Ile Ser Ser Leu Leu Ile Val Leu Val Ser Tyr Ile Leu Leu 210 215 220 Met Glu Ala Ile Met Tyr Val Gln Pro Lys Ser Ser His Ser Phe Asp 225 230 235 240 Thr Asp Lys Ile Ala Ser Ala Phe Tyr Thr Leu Ile Ile Pro Met Leu 245 250 255 Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Leu 260 265 270 His Arg Val Trp Lys Asn Leu His Ile Leu Pro Met 275 280

<210> 739 <211> 948 <212> DNA <213> Canis familiaris <400> 739

atggcctcag ggaacctgac ccacctgact gagttcattc tcaggggagt ctcagaccgc 60 ccagacctcc agatgccact cttctttgtt ttcctggtga tctatgggct caccatggca 120 gggaacctgg gcatcatcac cctcaccagt gttgactcgc agcttcaaac gcccatgtac 180 ttcttcctca ggcacttggc tatcatcaat cttggcgatt ctactgtcat tgcccctaag 240 atgctggtca acttcttggc ttcaaagaaa accatatcct actatggatg tgcagcccag 300 ctgggtggct tcttagtttt tatcgtgggg gagattttca tgctggctgc aatggcctac 360 gaccgctacg tggctatttg caaccccctg ctctacatgg tggtggtatc tccgcagatc 420 tgccttctgc tggtgtccct cacatacctc tacagtctga ccacagcact gacggtctcc 480 tgctgtgtgt tctctgtgtc atactgctct tccaatgtca tcaaccattt ttactgtgat 540

Page 829

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actgtccctt tgttggcatt gtcctgttct gatacctaca ttccagaaac agcggtgttt 600 acctctgctg ggaccaattt gtttttctcc atgattattg ttctaacctc ctacttccac 660 attgtccttg ccattttgag gatacgttcc tcagagggcc gaagaaaagc cttttccacc 720 tgtgcctccc acatgatggc tgtcactgtg ttctatggga ccattctctt tatgtatttg 780 caaccaagga ccaaccactc attagatact gataaaatgg cctctgtctt ctacactctc 840 gtgataccaa tgctgaatcc cctcatttac agcctaagga acaaggatgt gaaggatgca 900 ttcaagagat tcctaaagag cccttgccag tctttcaaat taatgtaa 948

<210> 740 <211> 315 <212> PRT <213> Canis familiaris <400> 740

Met Ala 1 Ser Gly Asn 5 Leu Thr His Leu Thr Glu Phe Ile Leu Arg Gly 10 15 Val Ser Asp Arg Pro Asp Leu Gln Met Pro Leu Phe Phe Val Phe Leu 20 25 30 Val Ile Tyr Gly Leu Thr Met Ala Gly Asn Leu Gly Ile Ile Thr Leu 35 40 45 Thr Ser Val Asp Ser Gln Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 His Leu Ala Ile Ile Asn Leu Gly Asp Ser Thr Val Ile Ala Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Ala Ser Lys Lys Thr Ile Ser Tyr Tyr Gly 85 90 95 Cys Ala Ala Gln Leu Gly Gly Phe Leu Val Phe Ile Val Gly Glu Ile 100 105 110 Phe Met Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125

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Pro Leu 130 Leu Tyr Met Val Val Val Ser Pro Gln Ile Cys Leu Leu Leu 135 140 Val Ser Leu Thr Tyr Leu Tyr Ser Leu Thr Thr Ala Leu Thr Val Ser 145 150 155 160 Cys Cys Val Phe Ser Val Ser Tyr Cys Ser Ser Asn Val Ile Asn His 165 170 175 Phe Tyr Cys Asp Thr Val Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 Tyr Ile Pro Glu Thr Ala Val Phe Thr Ser Ala Gly Thr Asn Leu Phe 195 200 205 Phe Ser Met Ile Ile Val Leu Thr Ser Tyr Phe His Ile Val Leu Ala 210 215 220 Ile Leu Arg Ile Arg Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Met Met Ala Val Thr Val Phe Tyr Gly Thr Ile Leu 245 250 255 Phe Met Tyr Leu Gln Pro Arg Thr Asn His Ser Leu Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Phe Lys Arg Phe 290 295 300 Leu Lys Ser Pro Cys Gln Ser Phe Lys Leu Met

305 310 315 <210> 741 <211> 951 <212> DNA

Page 831

069269_0225_SL.TXT <213> Canis familiaris <400> 741 atgacctgga tgaacagaca aaatctaaca gtgttaacag aattcatcct aatgggaatc 60 accgaccatc ctgagctgca ggctctcttc tttgggcttt tcctcatcat ctacacagtt 120 tcagtggtgg gcaacctggg catgatcatc ctcaccaagg tggactccag gctccaaaca 180 cccatgtact tcttcctcag acacctggct ttcattgatc ttggctactc atcagctgtg 240 gcacccaaaa tgttagtaaa ttttgtagct gatcaaaata ccatccccta taactggtgc 300 gctacccagc tggctttctt catcttgttc atcatcagtg agctgttcat tctgtcagca 360 atggcctatg accgctatgt ggccatctgt aaccctctgc tctacaccgt tgttatgtca 420 caaagggcgt gctgggtgct agtagcaatc ccttatgtct acagttcctg tctctctctg 480 ataatcacca tcaagatttt tatggcatcc ttctgtggac ataatgtcat tagacatttt 540 tactgtgaca atcttccttt gttaactttg ctgtgttcaa gcacacgtga cattgagttg 600 ataatactga tcttttcagc atttaatttg atttcctccc ttctcatagt gcttgtgtcc 660 tacatcctca tccttatggc catcctgagg atgaactcca cagagggcag gcacaaggcc 720 ttctccacct gtggatccca cctgacggtg gttgttgtat tgtatgtcac tctcttcttc 780 atgtacgtgc agcccaaatc cagtcattcc tttgatactg ataaaattgc ctctatattt 840 tacactttga taatccctat gctgaatccc atgatctaca gcctaaggaa caaagaggta 900 aaagatgccc tgcatagaat atggaaaaac ctgcataaac cacctatgta g 951 <210> 742 <211> 316 <212> PRT <213> Canis familiaris <400> 742

Met Thr Trp Met Asn Arg Gln Asn Leu Thr Val Leu Thr Glu Phe Ile 1 5 10 15 Leu Met Gly Ile Thr Asp His Pro Glu Leu Gln Ala Leu Phe Phe Gly 20 25 30 Leu Phe Leu Ile Ile Tyr Thr Val Ser Val Val Gly Asn Leu Gly Met

35 40 45

Page 832

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Ile Ile 50 Leu Thr Lys Val Asp Ser 55 Arg Leu Gln Thr Pro Met Tyr 60 Phe Phe Leu Arg His Leu Ala Phe Ile Asp Leu Gly Tyr Ser Ser Ala Val 65 70 75 80 Ala Pro Lys Met Leu Val Asn Phe Val Ala Asp Gln Asn Thr Ile Pro 85 90 95 Tyr Asn Trp Cys Ala Thr Gln Leu Ala Phe Phe Ile Leu Phe Ile Ile 100 105 110 Ser Glu Leu Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Thr Val Val Met Ser Gln Arg Ala Cys 130 135 140 Trp Val Leu Val Ala Ile Pro Tyr Val Tyr Ser Ser Cys Leu Ser Leu 145 150 155 160 Ile Ile Thr Ile Lys Ile Phe Met Ala Ser Phe Cys Gly His Asn Val 165 170 175 Ile Arg His Phe Tyr Cys Asp Asn Leu Pro Leu Leu Thr Leu Leu Cys 180 185 190 Ser Ser Thr Arg Asp Ile Glu Leu Ile Ile Leu Ile Phe Ser Ala Phe 195 200 205 Asn Leu Ile Ser Ser Leu Leu Ile Val Leu Val Ser Tyr Ile Leu Ile 210 215 220 Leu Met Ala Ile Leu Arg Met Asn Ser Thr Glu Gly Arg His Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Val Val Leu Tyr Val 245 250 255

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Thr Leu Phe Phe Met Tyr Val Gln Pro 265 Lys Ser Ser His Ser 270 Phe Asp 260 Thr Asp Lys Ile Ala Ser Ile Phe Tyr Thr Leu Ile Ile Pro Met Leu 275 280 285 Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Leu 290 295 300 His Arg Ile Trp Lys Asn Leu His Lys Pro Pro Met 305 310 315

<210> 743 <211> 948 <212> DNA <213> Canis familiaris <400> 743

atggcctcag ggaacctgac ccacctgact gagttcattc tcaggggagt ctcagaccac 60 ccagacctcc agatgccact cttctttgtt ttcctggtga tctatgggct caccgtggca 120 gggaacctgg gcatcatcac cctcaccagt gttgactcgc agcttcaaac gcccatgtac 180 ttcttcctca ggcacttggc tatcatcaat cttggcgatt ctactgtcat tgcccctaag 240 atgctggtca acttcttggc ttcaaagaaa accatatcct actatggatg tgcagcccag 300 ctgggtggct tcttagtttt tatcgtgggg gagattttca tgctggctgc aatggcctac 360 gaccgctacg tggctatttg caaccccctg ctctacatgg tggtggtatc tccgcagatc 420 tgccttctgc tggtgtccct cacatacctc tacagtctga ccacagcact gaccgtttcc 480 tcctgtgtgt tctctgtgtc atactgctct tccaatgtca tcaaccattt ttactgtgat 540 actgtccctt tgttggcatt gtcctgttct gatgcctaca ttccagaaac agtggtgttt 600 gccttttcag ggaccaattt gtttttctcc atgattattg ttctaacctc ctacttccac 660 attgtccttg ccattttgag gatacgttcc tcagagggcc gaagaaaagc cttttccacc 720 tgtgcctccc acatgatggc tgtcactgtg ttctatggga cccttctctt catgtatttg 780 caaccaagga ccaaccactc attagatact gataaaatgg cctctgtctt ctacaccctg 840

Page 834

900

948

069269_0225_SL.TXT gtgataccaa tgctgaatcc cctcatttac agcctaagga acaaggatgt gaaggatgca ttcaagagat tcctaaagag cccttgccag gctttcaaat tagtgtaa <210> 744 <211> 315 <212> PRT <213> Canis familiaris <400> 744

Met 1 Ala Ser Gly Asn Leu Thr His 5 Leu Thr Glu Phe Ile Leu Arg Gly 10 15 Val Ser Asp His Pro Asp Leu Gln Met Pro Leu Phe Phe Val Phe Leu 20 25 30 Val Ile Tyr Gly Leu Thr Val Ala Gly Asn Leu Gly Ile Ile Thr Leu 35 40 45 Thr Ser Val Asp Ser Gln Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 His Leu Ala Ile Ile Asn Leu Gly Asp Ser Thr Val Ile Ala Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Ala Ser Lys Lys Thr Ile Ser Tyr Tyr Gly 85 90 95 Cys Ala Ala Gln Leu Gly Gly Phe Leu Val Phe Ile Val Gly Glu Ile 100 105 110 Phe Met Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Val Val Val Ser Pro Gln Ile Cys Leu Leu Leu 130 135 140 Val Ser Leu Thr Tyr Leu Tyr Ser Leu Thr Thr Ala Leu Thr Val Ser 145 150 155 160 Ser Cys Val Phe Ser Val Ser Tyr Cys Ser Ser Asn Val Ile Asn His

Page 835

069269_0225_S L.TXT 165 170 175 Phe Tyr Cys Asp Thr Val Pro Leu Leu Ala Leu Ser Cys Ser Asp Ala 180 185 190 Tyr Ile Pro Glu Thr Val Val Phe Ala Phe Ser Gly Thr Asn Leu Phe 195 200 205 Phe Ser Met Ile Ile Val Leu Thr Ser Tyr Phe His Ile Val Leu Ala 210 215 220 Ile Leu Arg Ile Arg Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Met Met Ala Val Thr Val Phe Tyr Gly Thr Leu Leu 245 250 255 Phe Met Tyr Leu Gln Pro Arg Thr Asn His Ser Leu Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Phe Lys Arg Phe 290 295 Leu Lys Ser Pro Cys Gln Ala Phe Lys Leu Val 305 310 315 <210> 745 <211> 975 <212> DNA <213> Canis familiaris 300 <400> 745 atggttgttc ccacagcaat ttcgcttaat ggcctggatg aacaaaatct aacagtgcta acagaattca tcctaatggg aatcaccgac catcctgagc tgcaggctct cttctttggg cttttcctca tcatctacac agtttcagtg gtgggcaacc tgggcatgat catcctcacc aaggtggact ccaggctcca aacacccatg tacttcttcc Page 836 tcagacacct ggctttcatt 1

120

180

240

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gatcttggct actcatcagc tgtggcaccc aaaatgttag taaattttgt agctgatcaa 300 aatacaatcc cctataactg gtgcgctacc cagctggctt tcttcatctt gttcatcatc 360 agtgagctgt tcaatctatc tgcaatggcc tatgaccgtt atgtggccat ctgtaaccct 420 ctgctctaca ccattgttat gtcacaaaga gtgtgctggg ggctgataac aatcccttat 480 gtctacagtg cctgtctctc tctgataatc accatcaaga tttttatggc atccttctgt 540 ggacataatg tcattagaca tttttactgt gatagtcttc ccttgttaac tttgctgtgt 600 tcaagcacac gtgacattga gttgataata ctgatctttt cagcatttaa tttgatttcc 660 tcccttctca tagtgcttgt gtcctacatc ctcatcctta tggccatcct taggatgaac 720 tctgcagagg gcaggcacaa ggccttctcc acctgtggat cccacctgac ggtggttgtt 780 gtattgtatg tcactctctt cttcatgtac gtgcagccca aatccagtca ttcctttgat 840 actgataaaa tcgcctctat attttacact ttgataatcc ctatgctgaa tcccatgatc 900 tacagtctaa ggaacaaaga ggtaaaaggt gccctgcata gaatatggaa aaacctgcat 960 aaaccacctg tgtag 975 <210> 746 <211> 324 <212> PRT <213> Canis familiaris <400> 746 Met Val Val Pro Thr Ala Ile Ser Leu Asn Gly Leu Asp Glu Gln Asn 1 5 10 15 Leu Thr Val Leu Thr Glu Phe Ile Leu Met Gly Ile Thr Asp His Pro 20 25 30 Glu Leu Gln Ala Leu Phe Phe Gly Leu Phe Leu Ile Ile Tyr Thr Val 35 40 45 Ser Val Val Gly Asn Leu Gly Met Ile Ile Leu Thr Lys Val Asp Ser 50 55 60 Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg His Leu Ala Phe Ile 65 70 75 80

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Asp Leu Gly Tyr Ser 85 Ser Ala Val Ala Pro 90 Lys Met Leu Val Asn 95 Phe Val Ala Asp Gln Asn Thr Ile Pro Tyr Asn Trp Cys Ala Thr Gln Leu 100 105 110 Ala Phe Phe Ile Leu Phe Ile Ile Ser Glu Leu Phe Asn Leu Ser Ala 115 120 125 Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Leu Tyr Thr 130 135 140 Ile Val Met Ser Gln Arg Val Cys Trp Gly Leu Ile Thr Ile Pro Tyr 145 150 155 160 Val Tyr Ser Ala Cys Leu Ser Leu Ile Ile Thr Ile Lys Ile Phe Met 165 170 175 Ala Ser Phe Cys Gly His Asn Val Ile Arg His Phe Tyr Cys Asp Ser 180 185 190 Leu Pro Leu Leu Thr Leu Leu Cys Ser Ser Thr Arg Asp Ile Glu Leu 195 200 205 Ile Ile Leu Ile Phe Ser Ala Phe Asn Leu Ile Ser Ser Leu Leu Ile 210 215 220 Val Leu Val Ser Tyr Ile Leu Ile Leu Met Ala Ile Leu Arg Met Asn 225 230 235 240 Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr Cys Gly Ser His Leu 245 250 255 Thr Val Val Val Val Leu Tyr Val Thr Leu Phe Phe Met Tyr Val Gln 260 265 270 Pro Lys Ser Ser His Ser Phe Asp Thr Asp Lys Ile Ala Ser Ile Phe 275 280 285

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Tyr Thr Leu Ile Ile Pro Met Leu Asn Pro Met Ile Tyr Ser Leu Arg 290 295 300 Asn Lys Glu Val Lys Gly Ala Leu His Arg Ile Trp Lys Asn Leu His 305 310 315 320 Lys Pro Pro Val

<210> 747 <211> 948 <212> DNA <213> Canis familiaris <400> 747

atggcctcag ggaacctgac ccacctgact gagttcattc ttaggggagt ctcagaccgc 60 ccagacctcc agatgccact cttctttgtt ttcctggtga tctatgggct caccgtggca 120 gggaacctgg gcatcatcac cctcaccagt gttgactcgc agcttcaaac acccatgtac 180 ttcttcctca ggcacttggc tatcatcaat cttggcgatt ctactgtcat tgcccctaag 240 atgctggtca acttcttggc ttcaaagaaa accatatcct actatggatg tgcagcccag 300 ctgggtggct tcttagtttt tatcgtgggg gagattttca tgctggctgc aatggcctac 360 gaccgctacg tggctatttg caaccccctg ctctacatgg tggtggtatc tccgcagatc 420 tgccttctgc tggtgtccct catatacctc tacagtctga ccacagcact gaccgtttcc 480 tcctgtgtgt tctctgtgtc atactgctct tccaacataa tcgaccattt ttactgtgat 540 aatgtccctt tgttggcatt gtcctgttct gatacctaca ttccagaaac agtagtgttt 600 acctctgccg ggaccaattt gtttttctcc atgattattg ttctaacctc ctacttccac 660 attgtccttg ccattttgag gatacgttcc tcagagggcc gacgaaaagc cttttccacc 720 tgtgcctccc acatgatggc tgtcactgtg ttctatggga cccttctctt catgtatttg 780 caaccaagga ccaaccactc attagatact gataaaatgg cctctgtctt ctacaccctg 840 gtgataccaa tgctgaatcc cctcatttac agcctaagga acaaggatgt gaaagatgca 900 ttcaagagat tcctaaagag cccttgccag gctttcaaat tagtgtaa 948

Page 839

069269_0225_SL.TXT <210> 748 <211> 315 <212> PRT <213> Canis familiaris <400> 748

Met 1 Ala Ser Gly Asn 5 Leu Thr His Leu Thr Glu Phe Ile Leu Arg Gly 10 15 Val Ser Asp Arg Pro Asp Leu Gln Met Pro Leu Phe Phe Val Phe Leu 20 25 30 Val Ile Tyr Gly Leu Thr Val Ala Gly Asn Leu Gly Ile Ile Thr Leu 35 40 45 Thr Ser Val Asp Ser Gln Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 His Leu Ala Ile Ile Asn Leu Gly Asp Ser Thr Val Ile Ala Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Ala Ser Lys Lys Thr Ile Ser Tyr Tyr Gly 85 90 95 Cys Ala Ala Gln Leu Gly Gly Phe Leu Val Phe Ile Val Gly Glu Ile 100 105 110 Phe Met Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Val Val Val Ser Pro Gln Ile Cys Leu Leu Leu 130 135 140 Val Ser Leu Ile Tyr Leu Tyr Ser Leu Thr Thr Ala Leu Thr Val Ser 145 150 155 160 Ser Cys Val Phe Ser Val Ser Tyr Cys Ser Ser Asn Ile Ile Asp His 165 170 175 Phe Tyr Cys Asp Asn Val Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr

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Tyr Ile Pro Glu Thr Val Val Phe Thr Ser Ala Gly Thr Asn Leu Phe 195 200 205 Phe Ser Met Ile Ile Val Leu Thr Ser Tyr Phe His Ile Val Leu Ala 210 215 220 Ile Leu Arg Ile Arg Ser Ser Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Met Met Ala Val Thr Val Phe Tyr Gly Thr Leu Leu 245 250 255 Phe Met Tyr Leu Gln Pro Arg Thr Asn His Ser Leu Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Phe Lys Arg Phe 290 295 300 Leu Lys Ser Pro Cys Gln Ala Phe Lys Leu Val

305 310 315 <210> 749 <211> 921 <212> DNA <213> Canis familiaris <400> 749 atgaaaaatg tcactgaagt tactacattt gtactaaagg gcttcacaga caaacttgag ctacaaatca tcttattctt cctgtttcta acaatctatg tctttactct gatgggaaat ttaggactgg ttgcattggt cattggggat tcccggctcc acaaccccat gtactatttt ctgagtgtat tatcatctgt ggatgcctgc tattcttcag taattactcc aaatatgcta gtagatttta tgtcaaagaa taaagtcatt tcattccttg gatgtgcagc acagatgttt ctcgctgtta cttttgggac cacagaatgc tttctcttgg ccgccatggc ttatgatcgc Page 841

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tatgtagcaa tctacaaccc tctcctatat tctgtgagca tgtcgcccag agtctatgtg 420 ccactcatca ttgcttccta tgttggtggc attttgcatg cttctgtaca cacagtggcc 480 acgttcagcc tatccttctg tgcttcaaat gaaattagac atgtcttttg tgacatccct 540 ccactacttg ctatttcttg ttctgacacc cacacaaacc agctactgct cttctatttt 600 gcgggatcta ttgagataac tactatactg gtagtcctga tctcctatgg tttcattgtc 660 ttggtaattc tgaggatgca ttctgctgaa ggcagacgaa aaatcttttc tacatgtggc 720 tctcacttaa ctggagtgtc aatctttcat ggtacagttc tcttcatgta tgtgagacca 780 agttccagct atgccctgga ccatgacatg atagtgtcaa tattttacac gattgtgatt 840 cccatgctga atcctatcat ctatagtttg aggaacaaag atgtaaaaga tgcaatgcag 900 aaagtgttta ggaaaaattg a 921

<210> 750 <211> 306 <212> PRT <213> Canis familiaris <400> 750

Met 1 Lys Asn Val Thr Glu 5 Val Thr Thr Phe Val Leu Lys Gly Phe Thr 10 15 Asp Lys Leu Glu Leu Gln Ile Ile Leu Phe Phe Leu Phe Leu Thr Ile 20 25 30 Tyr Val Phe Thr Leu Met Gly Asn Leu Gly Leu Val Ala Leu Val Ile 35 40 45 Gly Asp Ser Arg Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu 50 55 60 Ser Ser Val Asp Ala Cys Tyr Ser Ser Val Ile Thr Pro Asn Met Leu 65 70 75 80 Val Asp Phe Met Ser Lys Asn Lys Val Ile Ser Phe Leu Gly Cys Ala 85 90 95

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Ala Gln Met Phe 100 Leu Ala Val Thr Phe Gly Thr Thr Glu Cys Phe Leu 105 110 Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Tyr Asn Pro Leu 115 120 125 Leu Tyr Ser Val Ser Met Ser Pro Arg Val Tyr Val Pro Leu Ile Ile 130 135 140 Ala Ser Tyr Val Gly Gly Ile Leu His Ala Ser Val His Thr Val Ala 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys Ala Ser Asn Glu Ile Arg His Val Phe 165 170 175 Cys Asp Ile Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Thr 180 185 190 Asn Gln Leu Leu Leu Phe Tyr Phe Ala Gly Ser Ile Glu Ile Thr Thr 195 200 205 Ile Leu Val Val Leu Ile Ser Tyr Gly Phe Ile Val Leu Val Ile Leu 210 215 220 Arg Met His Ser Ala Glu Gly Arg Arg Lys Ile Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Gly Val Ser Ile Phe His Gly Thr Val Leu Phe Met 245 250 255 Tyr Val Arg Pro Ser Ser Ser Tyr Ala Leu Asp His Asp Met Ile Val 260 265 270 Ser Ile Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Met Gln Lys Val Phe Arg 290 295 300

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Lys Asn

305 <210> 751 <211> 945 <212> DNA <213> Canis familiaris <400> 751

atgaaaaatg tgactgaggc caccatgttt atattgatgg gcttcacaga tgattttgag 60 atgcaggtct tcctattttt actatttcta gcaatctatc tttttactct gataggaaac 120 ttgggactgg ttatattggt gatgggggaa tctcggctcc acaaccccat gtattatttt 180 ctgagcgttt tatcattcct ggatgcctgc tattcttcag ttgtcacccc aaaaatgttg 240 gtcaatttcc tagcagagga taaatccatt tcctatctcg gatgtgcagc acagatgctt 300 ctcttcgtta cttttggaac cacagaatgc tttctcttgg ctgccatggc ttatgaccgc 360 tatgtagcaa tctacaaccc tctcctgtat tccgtgagca tgtcacccag ggtctatgtg 420 ccactcatcg ttgcttccta tgttggtggc attttgcatg cttctgtaca cacagtggcc 480 acgttcagcc tatccttctg tgcttccaat gaaattagac atgtcttttg tgacatccct 540 ccactacttg ccatttcgtg ttctgacacc cacacaaacc agctgctgct cttctacttc 600 gtgggctcta ttgagatagt cactatcctc attgttctga tctcctatgg tttcattctc 660 ttggccattc tgaacatcca ttctgccgag gggaggcgga aagtcttttc tacgtgtggt 720 tctcacctaa ctggagtgtc aatttatcat ggaaccatcc ttttcatata tatgagacca 780 agttccagtt atgctttgga gcatgacatg atagtgtcaa tattttacac gattgtgatt 840 cctatgctga atcccatcat ctacagttta aggaacaaag atgtaaaaga ggcgatgaag 900 aaattgttta tgagaaattg gttcttaagt aaaacacata attag 945

<210> 752 <211> 314 <212> PRT <213> Canis familiaris <400> 752

Met Lys Asn Val Thr Glu Ala Thr Met Phe Ile Leu Met Gly Phe Thr 1 5 10 15

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Asp Asp Phe Glu 20 Met Gln Val Phe Leu Phe Leu Leu Phe Leu Ala Ile 25 30 Tyr Leu Phe Thr Leu Ile Gly Asn Leu Gly Leu Val Ile Leu Val Met 35 40 45 Gly Glu Ser Arg Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu 50 55 60 Ser Phe Leu Asp Ala Cys Tyr Ser Ser Val Val Thr Pro Lys Met Leu 65 70 75 80 Val Asn Phe Leu Ala Glu Asp Lys Ser Ile Ser Tyr Leu Gly Cys Ala 85 90 95 Ala Gln Met Leu Leu Phe Val Thr Phe Gly Thr Thr Glu Cys Phe Leu 100 105 110 Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Tyr Asn Pro Leu 115 120 125 Leu Tyr Ser Val Ser Met Ser Pro Arg Val Tyr Val Pro Leu Ile Val 130 135 140 Ala Ser Tyr Val Gly Gly Ile Leu His Ala Ser Val His Thr Val Ala 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys Ala Ser Asn Glu Ile Arg His Val Phe 165 170 175 Cys Asp Ile Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Thr 180 185 190 Asn Gln Leu Leu Leu Phe Tyr Phe Val Gly Ser Ile Glu Ile Val Thr 195 200 205 Ile Leu Ile Val Leu Ile Ser Tyr Gly Phe Ile Leu Leu Ala Ile Leu 210 215 220

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Asn 225 Ile His Ser Ala Glu Gly Arg Arg Lys Val Phe Ser Thr Cys Gly 230 235 240 Ser His Leu Thr Gly Val Ser Ile Tyr His Gly Thr Ile Leu Phe Ile 245 250 255 Tyr Met Arg Pro Ser Ser Ser Tyr Ala Leu Glu His Asp Met Ile Val 260 265 270 Ser Ile Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Met Lys Lys Leu Phe Met 290 295 300 Arg Asn Trp Phe Leu Ser Lys Thr His Asn 305 310

<210> 753 <211> 567 <212> DNA <213> Canis familiaris <400> 753 ttgagactgg ttatattggt cattggagat tctcggctcc acaaccccat gtattatttt 60 ctgagtgttt tatcattcct ggatgcctgc tattcttcag ttgtcacccc aaaaatgttg 120 gtcaatttcc tagcagagga taaatccatt tcctatctca gatgtgcagc acagatgctt 180 ctcttcgtta cttttggaac cacagaatgc tttctcttgg ctgccatggc ttatgaccgc 240 tatgtagcaa tctacaaccc tctcctgtat tccgtgagca tgtcacccag ggtctatgtg 300 ccactcatcg ttgcttccaa tgttggtcgc attttgcatg cttctgtaca cacagtggcc 360 acgttcagcc tatctttctg tgcatccaat gaaattagac atgtcttttg tgacatccct 420 ccactacttg ccatttcttg ttctgacatc cacacaagcc atacatacat acatacatgc 480 atacatatac acacacatat atataaaaca tgtgtgtaaa atatatataa tgtatatata 540 tggagtctat acaatgtaca tacatct 567

Page 846

069269_0225_SL.TXT <210> 754 <211> 172 <212> PRT <213> Canis familiaris <400> 754

Leu Arg Leu Val Ile Leu Val Ile Gly Asp Ser Arg Leu His Asn Pro 1 5 10 15 Met Tyr Tyr Phe Leu Ser Val Leu Ser Phe Leu Asp Ala Cys Tyr Ser 20 25 30 Ser Val Val Thr Pro Lys Met Leu Val Asn Phe Leu Ala Glu Asp Lys 35 40 45 Ser Ile Ser Tyr Leu Arg Cys Ala Ala Gln Met Leu Leu Phe Val Thr 50 55 60 Phe Gly Thr Thr Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg 65 70 75 80 Tyr Val Ala Ile Tyr Asn Pro Leu Leu Tyr Ser Val Ser Met Ser Pro 85 90 95 Arg Val Tyr Val Pro Leu Ile Val Ala Ser Asn Val Gly Arg Ile Leu 100 105 110 His Ala Ser Val His Thr Val Ala Thr Phe Ser Leu Ser Phe Cys Ala 115 120 125 Ser Asn Glu Ile Arg His Val Phe Cys Asp Ile Pro Pro Leu Leu Ala 130 135 140 Ile Ser Cys Ser Asp Ile His Thr Ser His Thr Tyr Ile His Thr Cys 145 150 155 160 Ile His Ile His Thr His Ile Tyr Lys Thr Cys Val

165 170 <210> 755 <211> 963

Page 847

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 755 atgaaaaatg tgactgaggc caccatgttt atattgatgg gcttcacaga tgattttgag 60 gtgcaggtct tcctattttt actatttcta gcaatctatc tttttactct gataggaaac 120 ttgggactgg ttatattggt gatgggggaa tctcggctcc acaaccccat gtattatttt 180 ctgagcgttt tatcattcct ggatgcctgc tattcttcag ttgtcacccc aaaaatgttg 240 gtcaatttcc tagcagagga taaatccatt tcctatctcg gatgtgcagc acagatgctt 300 ctcttcgtta cttttggaac cacagaatgc tttctcttgg ctgccatggc ttatgaccgc 360 tatgtagcaa tctacaaccc tctcctgtat tccgtgagca tgtcacccag agtctatgtg 420 ccactcatcg ttgcttccta tgttggtggc attttgcatg cttctgtaca cacagtggcc 480 acgttcagcc tatccttctg tgcttccaat gaaattagac atgtcttttg tgacatccct 540 ccactacttg ccatttcgtg ttctgacacc cacacaaacc agctgctgct cttctacttc 600 gtgggctcta ttgagatagt cactatcctc attgttctga tctcctatgg tttcattctc 660 ttggccattc tgaacatcca ttctgccgag gggaggcgta aagtcttttc tacgtgtggt 720 tctcacctaa ctggagtgtc aatttatcat ggaaccatcc ttttcatgta tgtgagacca 780 agttccagct atgccctgga ccatgacatg atagtgtcaa tattttacac gattgtgatt 840 cctatgctga atcccatcat ctacagttta aggaacaaag atgtaaaagc agcaatgaag 900 aaatcgtttg gtaaaaattg gtgtatcaat aaagtacact tttcacattc accattaaat 960 taa 963 <210> 756 <211> 320 <212> PRT <213> Canis familiaris <400> 756

Met Lys Asn Val Thr Glu Ala Thr Met Phe Ile Leu Met Gly Phe Thr 1 5 10 15

Asp Asp Phe Glu Val Gln Val Phe Leu Phe Leu Leu Phe Leu Ala Ile 20 25 30

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Tyr Leu Phe 35 Thr Leu Ile Gly Asn Leu Gly Leu Val Ile Leu Val Met 40 45 Gly Glu Ser Arg Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu 50 55 60 Ser Phe Leu Asp Ala Cys Tyr Ser Ser Val Val Thr Pro Lys Met Leu 65 70 75 80 Val Asn Phe Leu Ala Glu Asp Lys Ser Ile Ser Tyr Leu Gly Cys Ala 85 90 95 Ala Gln Met Leu Leu Phe Val Thr Phe Gly Thr Thr Glu Cys Phe Leu 100 105 110 Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Tyr Asn Pro Leu 115 120 125 Leu Tyr Ser Val Ser Met Ser Pro Arg Val Tyr Val Pro Leu Ile Val 130 135 140 Ala Ser Tyr Val Gly Gly Ile Leu His Ala Ser Val His Thr Val Ala 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys Ala Ser Asn Glu Ile Arg His Val Phe 165 170 175 Cys Asp Ile Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Thr 180 185 190 Asn Gln Leu Leu Leu Phe Tyr Phe Val Gly Ser Ile Glu Ile Val Thr 195 200 205 Ile Leu Ile Val Leu Ile Ser Tyr Gly Phe Ile Leu Leu Ala Ile Leu 210 215 220 Asn Ile His Ser Ala Glu Gly Arg Arg Lys Val Phe Ser Thr Cys Gly 225 230 235 240

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Ser His Leu Thr Gly Val Ser Ile Tyr His Gly Thr Ile Leu Phe Met 245 250 255 Tyr Val Arg Pro Ser Ser Ser Tyr Ala Leu Asp His Asp Met Ile Val 260 265 270 Ser Ile Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Ala Ala Met Lys Lys Ser Phe Gly 290 295 300 Lys Asn Trp Cys Ile Asn Lys Val His Phe Ser His Ser Pro Leu Asn 305 310 315 320

<210> 757 <211> 939 <212> DNA <213> Canis familiaris <400> 757 atgaagaatg ctacagaagt caccatattt gtactgaagg gcttcacaga taagcttgag ctgcaaacag ccttgttctt cctgtttcta gcaacctacc tctttactat gatgggaaat ttggttttag ttttgttggt cattgtagat tcccagctcc acaaccccat gtactatttt ctgagtgtgt tatcatctgt ggatgcctgc ttttcctccg taattactcc aaatatgtta gtagatttta tgttaaagaa taaagtcatt tcattccttg gatgtgcagc acagatgttt cttgctgtta cttttggaac cacagaatgc tttctcttgg ctgccatggc ttatgaccgc tatgtagcaa tctacaaccc tctcctgtat tctgtgggca tgtcacccag ggtctatgtg ccactcatcg ttgcttccta tgttggtggc attttgcatg cttctgtaca cacagtggcc acgttcagcc tatccttctg tgcatccaat gaaattagac atgtcttttg tgacatccct ccactacttg ccatttcgtg ttctgacacc cacacaaacc agctgctgct cttctacttc gtgggctcta ttgagatagt cactatcctc attgttctga tctcctatgg tttcattgtc ttggccattc tgaacattca ttctgctgag gggaggtgga aagtcttttc tacgtgtggt tctcacctaa ctggagtgtc aatttatcat ggaaccatcg ttttcatgta tgtgagacca Page 850

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480

540

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720

780

069269_0225_SL.TXT agttccagct cccatgctga agaatgtttc atgctccaga atcccatcat agaaaaaatg ccatgacatg ctacagttta gtttattaat atagtttcaa tgttttatag cattgtgatt aggaacaaag atgtaaaaga ggcaatgaaa tcatactaa

840

900

939 <210> 758 <211> 312 <212> PRT <213> Canis familiaris <400> 758

Met 1 Lys Asn Ala Thr 5 Glu Val Thr Ile Phe Val Leu Lys Gly Phe Thr 10 15 Asp Lys Leu Glu Leu Gln Thr Ala Leu Phe Phe Leu Phe Leu Ala Thr 20 25 30 Tyr Leu Phe Thr Met Met Gly Asn Leu Val Leu Val Leu Leu Val Ile 35 40 45 Val Asp Ser Gln Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu 50 55 60 Ser Ser Val Asp Ala Cys Phe Ser Ser Val Ile Thr Pro Asn Met Leu 65 70 75 80 Val Asp Phe Met Leu Lys Asn Lys Val Ile Ser Phe Leu Gly Cys Ala 85 90 95 Ala Gln Met Phe Leu Ala Val Thr Phe Gly Thr Thr Glu Cys Phe Leu 100 105 110 Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Tyr Asn Pro Leu 115 120 125 Leu Tyr Ser Val Gly Met Ser Pro Arg Val Tyr Val Pro Leu Ile Val 130 135 140 Ala Ser Tyr Val Gly Gly Ile Leu His Ala Ser Val His Thr Val Ala 145 150 155 160

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Thr Phe Ser Leu Ser Phe Cys Ala Ser Asn Glu Ile Arg His Val Phe 165 170 175 Cys Asp Ile Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Thr 180 185 190 Asn Gln Leu Leu Leu Phe Tyr Phe Val Gly Ser Ile Glu Ile Val Thr 195 200 205 Ile Leu Ile Val Leu Ile Ser Tyr Gly Phe Ile Val Leu Ala Ile Leu 210 215 220 Asn Ile His Ser Ala Glu Gly Arg Trp Lys Val Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Gly Val Ser Ile Tyr His Gly Thr Ile Val Phe Met 245 250 255 Tyr Val Arg Pro Ser Ser Ser Tyr Ala Pro Asp His Asp Met Ile Val 260 265 270 Ser Met Phe Tyr Ser Ile Val Ile Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Met Lys Arg Met Phe Gln 290 295 300 Lys Lys Trp Phe Ile Asn Ser Tyr 305 310

<210> 759 <211> 936 <212> DNA <213> Canis familiaris <400> 759 atggagagaa agaataacac acccgtgcat gacttcatct ttctgggatt gacagattct gaagagatcc agtcgatcct cttcatgctg tttctcctaa tatacctggt tactgtgctg

120

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ggcaatgcag ggatgatact gataatccac ctggatctcc agctacacac ccccatgtat 180 tttttcctta gtcacctgtc attccttgac ctcagttact caactgtcat cacacctaaa 240 accttagaga acttactgac ttctaccaag catatttcat acgggggctg cctcgtccag 300 atgtattttt ttgtcttctt gggggccact gaatgtttcc ttctctcctc aatggcctat 360 gatcgctatg ttgctatctg taatcctctg cattacccag tggttatgtc cacaagattc 420 tgctgttccc tcgtctttgg gtcctatttg attggctttg tggactcctt tgtcactgtg 480 cttcgaatga gcagattgca tttctgtgac tccaatgtaa tccatcactt cttctgtgat 540 acacccccag ttttagccct gtcttgcact gacacacatg acatcgaaat catgatattt 600 attgttgctg gctccaccct aatggtgtct cttatcacaa tatctgtgtc ctatgtgtcc 660 attctgtcta ctatcctgaa aattacttcc acttcaggaa agcgaaaagc cttctctact 720 tgtgcctctc atctcctggg agtcaccatc ttttatggca ctatgatttt tacttattta 780 aagccaagta agtcttactc cctgggaaag gatcaagtgg cttctgtttt ttatactatt 840 gtgatcccca tgctgaatcc acttatttat agtcttagga acaaagaagt gaaaaatgct 900 ctcattagag tcatgcagaa gggagaaggc aattga 936

<210> 760 <211> 311 <212> PRT <213> Canis familiaris <400> 760

Met 1 Glu Arg Lys Asn Asn Thr Pro Val His Asp Phe Ile Phe Leu Gly 5 10 15 Leu Thr Asp Ser Glu Glu Ile Gln Ser Ile Leu Phe Met Leu Phe Leu 20 25 30 Leu Ile Tyr Leu Val Thr Val Leu Gly Asn Ala Gly Met Ile Leu Ile 35 40 45 Ile His Leu Asp Leu Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Leu Asp Leu Ser Tyr Ser Thr Val Ile Thr Pro Lys

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Thr Leu Glu Asn Leu Leu Thr Ser Thr Lys His Ile Ser Tyr Gly Gly 85 90 95 Cys Leu Val Gln Met Tyr Phe Phe Val Phe Leu Gly Ala Thr Glu Cys 100 105 110 Phe Leu Leu Ser Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu His Tyr Pro Val Val Met Ser Thr Arg Phe Cys Cys Ser Leu 130 135 140 Val Phe Gly Ser Tyr Leu Ile Gly Phe Val Asp Ser Phe Val Thr Val 145 150 155 160 Leu Arg Met Ser Arg Leu His Phe Cys Asp Ser Asn Val Ile His His 165 170 175 Phe Phe Cys Asp Thr Pro Pro Val Leu Ala Leu Ser Cys Thr Asp Thr 180 185 190 His Asp Ile Glu Ile Met Ile Phe Ile Val Ala Gly Ser Thr Leu Met 195 200 205 Val Ser Leu Ile Thr Ile Ser Val Ser Tyr Val Ser Ile Leu Ser Thr 210 215 220 Ile Leu Lys Ile Thr Ser Thr Ser Gly Lys Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Leu Gly Val Thr Ile Phe Tyr Gly Thr Met Ile 245 250 255 Phe Thr Tyr Leu Lys Pro Ser Lys Ser Tyr Ser Leu Gly Lys Asp Gln 260 265 270 Val Ala Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu

Page 854

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275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Leu Ile Arg Val 290 295 300 Met Gln Lys Gly Glu Gly Asn 305 310

<210> 761 <211> 918 <212> DNA <213> Canis familiaris <400> 761

atggctggaa acaatttcac tgaggtgacg gtcttcatcc tctctggatt tgcaaattac 60 cctgaactac aagtcagtct tttcttaatg tttctcttta tttatctgtt cactgttttg 120 gggaaccttg ggctgatcat gttaatcaga attgactctc agcttcacac accaatgtac 180 ttttttctta gcaacttagc attcattgac atattttatt cctccactgt aacacccaag 240 gcactggtaa atttccaatc ccaacagaaa accatctctt ttgttgcctg ctttgttcaa 300 atgtactttt ttgtgggttt ggtgtgcagt gagtgttttc ttctggggtc aatggcctag 360 gaccgctacg tagccatctg caatcctcta ttgtactcag tggttatgtc ccagaaagtg 420 tgcaactggc tgggagccct gccatatgca ataggcttca caaattctct ggtatcagtc 480 tgtgtgataa gtagtttgtc attctgtgat tccagcatca atcatttctt ctgtgatacc 540 acagctcttt tggccctatc ctgtgcagat gcattcagca cagaaatggt gatctttatt 600 ttagctggga tcacacttct cagttccctg ctcctcatca cggtcactta cactgccatc 660 atctcagcca tcctgaggat ccagtctaca gcaggcagac agaaggcctt ttccacctgt 720 gcatcccacc tcatgggtgt aactatcttc tatgggtctc tgattttcac atatttgcag 780 cctgataaca catcatccct gacccaggca caggtggcat ctgtcttcta taccattgtc 840 attccaatgc tgaatccact gatctacagt ctgaggaaca aagatgtgaa aaatgctctc 900 ctgagagtca tacacaga 918

<210> 762 <211> 171

Page 855

069269_0225_SL.TXT <212> PRT <213> Canis familiaris <400> 762

Met 1 Ser Gln Lys Val 5 Cys Asn Trp Leu Gly Ala Leu Pro Tyr Ala Ile 10 15 Gly Phe Thr Asn Ser Leu Val Ser Val Cys Val Ile Ser Ser Leu Ser 20 25 30 Phe Cys Asp Ser Ser Ile Asn His Phe Phe Cys Asp Thr Thr Ala Leu 35 40 45 Leu Ala Leu Ser Cys Ala Asp Ala Phe Ser Thr Glu Met Val Ile Phe 50 55 60 Ile Leu Ala Gly Ile Thr Leu Leu Ser Ser Leu Leu Leu Ile Thr Val 65 70 75 80 Thr Tyr Thr Ala Ile Ile Ser Ala Ile Leu Arg Ile Gln Ser Thr Ala 85 90 95 Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala Ser His Leu Met Gly Val 100 105 110 Thr Ile Phe Tyr Gly Ser Leu Ile Phe Thr Tyr Leu Gln Pro Asp Asn 115 120 125 Thr Ser Ser Leu Thr Gln Ala Gln Val Ala Ser Val Phe Tyr Thr Ile 130 135 140 Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp 145 150 155 160 Val Lys Asn Ala Leu Leu Arg Val Ile His Arg 165 170

<210> 763 <211> 903 <212> DNA <213> Canis familiaris

Page 856

069269_0225_SL.TXT <400> 763

gtggaagaga agaatcagac aggagtgact gaatttcttt tcttgagcct cacagatcat 60 ctccatcaac agattgtcct ctttgtcatg ctcctcttca tctatcttgt caccctgggg 120 ggtaacatag ggatgatcat tctcatatgg actgatccca gattccacac gcctatgtac 180 tttttctcag ccacttgtcc tttgttgatc tctgttcctc ttcttccatt gcccccaaga 240 tgctgtgtga tatctttgca gagaaaaaag gcatctcttt cacggggttg tgctgcacag 300 atatggttct ttgacctttc tgtggcaact gaatgttttc tcctggcttc catggcatat 360 gaccagtata tggccatctg taagcctttg ctatatagac ttattatgtc ccagagggtc 420 tgtgtgcagc ttgtggtagg gccttatgcc atggctctta tatacagcat gacctatatg 480 atgttggttt tgcttaccct tctgtggtca aatgtcatta atcatttctg tgatttttca 540 ccactgcttt ctcttgcatg tgcagacact tccatgattc agtttgtatt tttctttttg 600 gctggatcta tacaaatatt cagtggcctg atcatcatga tctcctacgt ttgcatcctg 660 gctgccttga agatccagac tgctgatggg aggcagaaag ctttctccac ttgctcttct 720 cacctggcca ttgtctccat gctgtatggg actcttttct ttatctatgt ttggcctggc 780 tcaatttcat ccctggatat caataaagtg atttctctat tttatactgt ggtaatcccc 840 atgttgaacc cccttatcta cagtctgaag aacaaggagg taaaaaaatg tattcaggaa 900

gaa 903 <210> 764 <211> 301 <212> PRT <213> Canis familiaris <400> 764

Val 1 Glu Glu Lys Asn Gln Thr Gly Val Thr Glu Phe Leu Phe Leu Ser 5 10 15 Leu Thr Asp His Leu His Gln Gln Ile Val Leu Phe Val Met Leu Leu 20 25 30 Phe Ile Tyr Leu Val Thr Leu Gly Gly Asn Ile Gly Met Ile Ile Leu 35 40 45

Page 857

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Ile Trp 50 Thr Asp Pro Arg Phe His 55 Thr Pro Met Tyr Phe Phe Ser 60 Ala Thr Cys Pro Leu Leu Ile Ser Val Pro Leu Leu Pro Leu Pro Pro Arg 65 70 75 80 Cys Cys Val Ile Ser Leu Gln Arg Lys Lys Ala Ser Leu Ser Arg Gly 85 90 95 Cys Ala Ala Gln Ile Trp Phe Phe Asp Leu Ser Val Ala Thr Glu Cys 100 105 110 Phe Leu Leu Ala Ser Met Ala Tyr Asp Gln Tyr Met Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Arg Leu Ile Met Ser Gln Arg Val Cys Val Gln Leu 130 135 140 Val Val Gly Pro Tyr Ala Met Ala Leu Ile Tyr Ser Met Thr Tyr Met 145 150 155 160 Met Leu Val Leu Leu Thr Leu Leu Trp Ser Asn Val Ile Asn His Phe 165 170 175 Cys Asp Phe Ser Pro Leu Leu Ser Leu Ala Cys Ala Asp Thr Ser Met 180 185 190 Ile Gln Phe Val Phe Phe Phe Leu Ala Gly Ser Ile Gln Ile Phe Ser 195 200 205 Gly Leu Ile Ile Met Ile Ser Tyr Val Cys Ile Leu Ala Ala Leu Lys 210 215 220 Ile Gln Thr Ala Asp Gly Arg Gln Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Leu Ala Ile Val Ser Met Leu Tyr Gly Thr Leu Phe Phe Ile Tyr 245 250 255

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Val Trp Pro Gly Ser Ile Ser Ser Leu Asp Ile Asn Lys Val Ile Ser 260 265 270 Leu Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser 275 280 285 Leu Lys Asn Lys Glu Val Lys Lys Cys Ile Gln Glu Glu 290 295 300

<210> 765 <211> 945 <212> DNA <213> Canis familiaris <400> 765

atggattatg gaaatcagac tttggtgact gaattttttt ttgtgggctt aacaaatcaa 60 ttgcagcacc aggttgttct ctttgtgata tttctcttgg tttatcttgt tactcttctg 120 ggaaatgtgg ggatgatcac cctcatttgg ttggatcccc gactccacac acctatgtac 180 ttttttctta gccacttgtc ctttgtggat gtctgctctt cttctgccat tggtcctaag 240 atgttgactg acatctttgt ggagaaaaaa gtaatctctt tttttggttg tgctgctcag 300 atctgttttt ttggtcagtt tgtagtgact gagtgttttc tcctggcctc catggcatat 360 gaccggtata tggccatctg taagcccttg ctgtatacac tcattatgtc ccagcgtgtc 420 tgtgtgcagc tagtggtagg accttatgcc atgggtctga tgagcaccat gacccacacg 480 actttagcct ttaacctacc ttattgtggc ccccaaatca tcaatcactt cttctgtgac 540 cttcttcctg ttctgtcctt ggcatgtgca gacacccagg tcaatcagtt tctacttttc 600 atcttggctg gagctctagg tgtgctcagt ggtgtgatca tcctagtttc ctacacttac 660 attgtcatca ctatcctgag gatccgctct gctgcgggga ggcacaaagc cttttccacc 720 tgctcttcac acctgacagc tgtctccatc ctgtatggga cactcttctt tatctacgta 780 cgccccagtt ctagtttctc cctggacatc aataaagtgg tttcagtgtt ctatacatct 840 gtgactccta tgttgaaccc ccttatctac agcctgagaa acagagaggt caaggattca 900 ttcagaagga cgtttgagaa gaagcagttt ctcatgagta gataa 945

Page 859

069269_0225_SL.TXT <210> 766 <211> 314 <212> PRT <213> Canis familiaris <400> 766

Met Asp Tyr Gly Asn Gln Thr Leu Val Thr Glu Phe Phe Phe Val Gly 1 5 10 15 Leu Thr Asn Gln Leu Gln His Gln Val Val Leu Phe Val Ile Phe Leu 20 25 30 Leu Val Tyr Leu Val Thr Leu Leu Gly Asn Val Gly Met Ile Thr Leu 35 40 45 Ile Trp Leu Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Val Cys Ser Ser Ser Ala Ile Gly Pro Lys 65 70 75 80 Met Leu Thr Asp Ile Phe Val Glu Lys Lys Val Ile Ser Phe Phe Gly 85 90 95 Cys Ala Ala Gln Ile Cys Phe Phe Gly Gln Phe Val Val Thr Glu Cys 100 105 110 Phe Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Thr Leu Ile Met Ser Gln Arg Val Cys Val Gln Leu 130 135 140 Val Val Gly Pro Tyr Ala Met Gly Leu Met Ser Thr Met Thr His Thr 145 150 155 160 Thr Leu Ala Phe Asn Leu Pro Tyr Cys Gly Pro Gln Ile Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Leu Pro Val Leu Ser Leu Ala Cys Ala Asp Thr 180 185 190

Page 860

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Gln Val Asn Gln Phe Leu Leu Phe Ile Leu Ala Gly Ala Leu Gly Val 195 200 205 Leu Ser Gly Val Ile Ile Leu Val Ser Tyr Thr Tyr Ile Val Ile Thr 210 215 220 Ile Leu Arg Ile Arg Ser Ala Ala Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ser Ile Leu Tyr Gly Thr Leu Phe 245 250 255 Phe Ile Tyr Val Arg Pro Ser Ser Ser Phe Ser Leu Asp Ile Asn Lys 260 265 270 Val Val Ser Val Phe Tyr Thr Ser Val Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Glu Val Lys Asp Ser Phe Arg Arg Thr 290 295 300 Phe Glu Lys Lys Gln Phe Leu Met Ser Arg

305 310 <210> 767 <211> 939 <212> DNA <213> Canis familiaris <400> 767

atggccaaca gaaatgtcag tgtggtaact gaattcattc tcctgggact gactgataac 60 cctgacctga acactgccct gttcgtgctg tttctctcaa tctacctcgt cacagtggtg 120 ggcaatgctt ggattatcgc agtaatctgg gtaagtgccc agctccattc ccccaagtac 180 tttttccttt gtcagttggc tttcttggat ttctgctatt cctcagtctt tattcctaag 240 atgttggtga actacataac aggacagaaa tccatctcct atcatggttg cctcctgcag 300 tattccttcg tcaacatgtt cttgaccacc gaatgcttcc tcctggccgc catggcctat 360

Page 861

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gatcggtatg tcgccatttg ctgcccactt cactacaaag gcctcatgac ccacacattc 420 tgtgtccact tggtgactgc ttgctaccta gtaggttctg ctagctcact cacccacctg 480 agcagcttgc tcagcctgtc tttctgtggg cccaacgtca tcaaccatta cttctgtgac 540 atcccactgc tttttcaact gtcctgttct gacacccaat ctagtgagat tttatttatt 600 gtcttctctg gcacaacatc ggtgactacc tttctgatag tggttagttc ttatctggga 660 atcctccgca ctgtcctgaa gttacactcc acaaggagca gatataaagc attctccaca 720 tgtgcttctc acctcacagt agtgactctt ttctatggaa cagtgatatt tacttatctg 780 ggaagcagct ctagctaccc acgggataga gccaaaatct tgtccatatt ttatactctt 840 ttgctaccag tcctaaattt cctgatatac agtgtgagaa acagagaggc caaagaagca 900 atgaaaagaa ttattttgag aaaagtattt gctcagtga 939

<210> 768 <211> 312 <212> PRT <213> Canis familiaris <400> 768

Met Ala Asn Arg Asn Val Ser Val Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Thr Asp Asn Pro Asp Leu Asn Thr Ala Leu Phe Val Leu Phe Leu 20 25 30 Ser Ile Tyr Leu Val Thr Val Val Gly Asn Ala Trp Ile Ile Ala Val 35 40 45 Ile Trp Val Ser Ala Gln Leu His Ser Pro Lys Tyr Phe Phe Leu Cys 50 55 60 Gln Leu Ala Phe Leu Asp Phe Cys Tyr Ser Ser Val Phe Ile Pro Lys 65 70 75 80 Met Leu Val Asn Tyr Ile Thr Gly Gln Lys Ser Ile Ser Tyr His Gly 85 90 95 Cys Leu Leu Gln Tyr Ser Phe Val Asn Met Phe Leu Thr Thr Glu Cys

Page 862

100

069269_0225_SL.TXT 105 110

Phe Leu Leu 115 Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Cys 120 125 Pro Leu His Tyr Lys Gly Leu Met Thr His Thr Phe Cys Val His Leu 130 135 140 Val Thr Ala Cys Tyr Leu Val Gly Ser Ala Ser Ser Leu Thr His Leu 145 150 155 160 Ser Ser Leu Leu Ser Leu Ser Phe Cys Gly Pro Asn Val Ile Asn His 165 170 175 Tyr Phe Cys Asp Ile Pro Leu Leu Phe Gln Leu Ser Cys Ser Asp Thr 180 185 190 Gln Ser Ser Glu Ile Leu Phe Ile Val Phe Ser Gly Thr Thr Ser Val 195 200 205 Thr Thr Phe Leu Ile Val Val Ser Ser Tyr Leu Gly Ile Leu Arg Thr 210 215 220 Val Leu Lys Leu His Ser Thr Arg Ser Arg Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Val Ile 245 250 255 Phe Thr Tyr Leu Gly Ser Ser Ser Ser Tyr Pro Arg Asp Arg Ala Lys 260 265 270 Ile Leu Ser Ile Phe Tyr Thr Leu Leu Leu Pro Val Leu Asn Phe Leu 275 280 285 Ile Tyr Ser Val Arg Asn Arg Glu Ala Lys Glu Ala Met Lys Arg Ile 290 295 300 Ile Leu Arg Lys Val Phe Ala Gln

Page 863

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305

310 <210> 769 <211> 939 <212> DNA <213> Canis familiaris <400> 769

atggctgatg ttaattttac attggttaca gagtttatcc ttttgggact gacagatcgt 60 gctgaactga aagttgtcct ctttgtgctt ttcctgctga tctataccat ttctttggtg 120 gggaatctag gaatggtctt tctaatccaa gtaactccca aactccaaac acccatgtat 180 catttcctta gctgcctgtc atttgttgat gcctgctatt catcagtctt tgcaccaaaa 240 atgctgctga acttctttgt tgaacgggag acaatctcat tctctgcatg cattgtgcag 300 tattttttat ttgtgtcact ccttaccact gagggcttct tgctggcggc aatggcttat 360 gaccgctaca tggccattgt gaacccttta ttttacacag tggctatgac taaaatagtt 420 tgcattgtcc tggtcattgg gtcatgtgta ggaggcttaa tcaactcatt gacacacaca 480 attggtttgg tgaaattgtc tttctgtggg ccaaatatca tcagtcactt cttctgtgac 540 cttcccccac tattgaagtt gtcatgttct gacacatcca tgaatgaact gttgctttta 600 atcttctctg gaattattgc tatgatcact ttcttgattg tgatgatctc ctatgtcttc 660 attgttgctg ctattctgag gatccgctca gcagcaggta gacacaaagc cttctccacc 720 tgtgcttcac atttaacggc tgtgacttta ttctatggct ctataagctt tagttacatt 780 caaccaagct ctcaatattc cttagaacaa gaaaaggtgg tatctgtgtt ttataccctg 840 gtgattccta tgttaaaccc agtgatttac agcctgagaa acaaggaagt aaaagatgct 900 gtgaaaagag ctacagaaat aaaatattgt ccttgttaa 939

<210> 770 <211> 312 <212> PRT <213> Canis familiaris <400> 770

Met Ala Asp Val Asn Phe Thr Leu Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15

Page 864

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Leu Thr Asp Arg 20 Ala Glu Leu Lys Val Val Leu Phe Val Leu Phe Leu 25 30 Leu Ile Tyr Thr Ile Ser Leu Val Gly Asn Leu Gly Met Val Phe Leu 35 40 45 Ile Gln Val Thr Pro Lys Leu Gln Thr Pro Met Tyr His Phe Leu Ser 50 55 60 Cys Leu Ser Phe Val Asp Ala Cys Tyr Ser Ser Val Phe Ala Pro Lys 65 70 75 80 Met Leu Leu Asn Phe Phe Val Glu Arg Glu Thr Ile Ser Phe Ser Ala 85 90 95 Cys Ile Val Gln Tyr Phe Leu Phe Val Ser Leu Leu Thr Thr Glu Gly 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Met Ala Ile Val Asn 115 120 125 Pro Leu Phe Tyr Thr Val Ala Met Thr Lys Ile Val Cys Ile Val Leu 130 135 140 Val Ile Gly Ser Cys Val Gly Gly Leu Ile Asn Ser Leu Thr His Thr 145 150 155 160 Ile Gly Leu Val Lys Leu Ser Phe Cys Gly Pro Asn Ile Ile Ser His 165 170 175 Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190 Ser Met Asn Glu Leu Leu Leu Leu Ile Phe Ser Gly Ile Ile Ala Met 195 200 205 Ile Thr Phe Leu Ile Val Met Ile Ser Tyr Val Phe Ile Val Ala Ala 210 215 220

Page 865

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Ile 225 Leu Arg Ile Arg Ser 230 Ala Ala Gly Arg His 235 Lys Ala Phe Ser Thr 240 Cys Ala Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Ser Ile Ser 245 250 255 Phe Ser Tyr Ile Gln Pro Ser Ser Gln Tyr Ser Leu Glu Gln Glu Lys 260 265 270 Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Val 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Val Lys Arg Ala 290 295 300 Thr Glu Ile Lys Tyr Cys Pro Cys 305 310

<210> 771 <211> 933 <212> DNA <213> Canis familiaris <400> 771

atggcaggtt ggaatcatac aggggtgaag gaattccttc tggtaggttt aacagaaaac 60 cctaatttgc agatccctct ttttttgctt ttcaccctta tttacttcac cactctggca 120 ggtaactggg gcatgattat gttgatctgg ttaaatgccc aacttcatac tcctatgtac 180 ttcttcctta gcaacctctc tttttgtgat atctgctact ctactgtctt tgctccaaag 240 atgttggtca atttcctatc gaaacacaag tccagcacat tttctggttg tgttctacag 300 agtttctttt ttgcagtata tgtaaccaca gaaggcatcc tcctatctat gatggcttat 360 gaccgctatg tggcaatagc taatcctttg ttgtatagag tcataatgac ccaaagagtt 420 tgtattcaga tggtccttgc atcttacttg ggtgggctca ttaactcact gacacataca 480 ataggtttgc tcaaactgga cttctgtggt cctaacattg tgaatcatta tttctgtgac 540 attccccctc ttctgagact ctcttgctct gatgcccaca acaatgagat gctgctttta 600 atattctctg gggtcattgc aatgttcact ttcactataa ttatggtctc ttatatgtgc 660

Page 866

069269_0225_SL.TXT attatcatgg ccatccagag aatccgctca gctgagggga ggcgcaaagc cttctctact tgtgcctctc atctgactgc cgtgacatta ttctatgggt ctgtgacctt tagttacatc cagccaagtt cccagtattc cctggaacag gagaaggtct ctgctgtgtt ttatacattg gtgatcccca tgctaaaccc attgatttat agcctacgaa ataaggatgt aaaagatgca gccaagaggt ccatatggtg gaagagaact taa

720

780

840

900

933 <210> 772 <211> 310 <212> PRT <213> Canis familiaris <400> 772

Met Ala Gly Trp 1 Asn 5 His Thr Gly Val Lys Glu Phe Leu Leu Val Gly 10 15 Leu Thr Glu Asn Pro Asn Leu Gln Ile Pro Leu Phe Leu Leu Phe Thr 20 25 30 Leu Ile Tyr Phe Thr Thr Leu Ala Gly Asn Trp Gly Met Ile Met Leu 35 40 45 Ile Trp Leu Asn Ala Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Cys Asp Ile Cys Tyr Ser Thr Val Phe Ala Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Ser Lys His Lys Ser Ser Thr Phe Ser Gly 85 90 95 Cys Val Leu Gln Ser Phe Phe Phe Ala Val Tyr Val Thr Thr Glu Gly 100 105 110 Ile Leu Leu Ser Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Ala Asn 115 120 125 Pro Leu Leu Tyr Arg Val Ile Met Thr Gln Arg Val Cys Ile Gln Met 130 135 140

Page 867

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Val Leu Ala 145 Ser Tyr Leu Gly Gly Leu Ile Asn Ser Leu Thr His Thr 150 155 160 Ile Gly Leu Leu Lys Leu Asp Phe Cys Gly Pro Asn Ile Val Asn His 165 170 175 Tyr Phe Cys Asp Ile Pro Pro Leu Leu Arg Leu Ser Cys Ser Asp Ala 180 185 190 His Asn Asn Glu Met Leu Leu Leu Ile Phe Ser Gly Val Ile Ala Met 195 200 205 Phe Thr Phe Thr Ile Ile Met Val Ser Tyr Met Cys Ile Ile Met Ala 210 215 220 Ile Gln Arg Ile Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Ser Val Thr 245 250 255 Phe Ser Tyr Ile Gln Pro Ser Ser Gln Tyr Ser Leu Glu Gln Glu Lys 260 265 270 Val Ser Ala Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Ala Lys Arg Ser 290 295 300 Ile Trp Trp Lys Arg Thr 305 310 <210> 773 <211> 939 <212> DNA <213> Canis familiaris <400> 773 atgtgggaga gcaattatac catgccaact gagtttcttc ttgttggatt cacagattat 60

Page 868

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ctacctctca gagtcacact attcttggta tttctcatag tctatacact aactatggta 120 ggaaatatga gtttaataat cctagttaat atcagttcta gccttcaaac tcctatgtat 180 tatctcctca gcaacttgtc tttcttagac atctgctatt ctacagcaat cgcacctaaa 240 atgctggtaa atttcttagc atccaggaaa agcatctctc cctatggctg tgcgctacaa 300 atgtttttct ttggttgttt tgctgatgct gagtgtctta ttctggcagc aatggcttat 360 gaccgctatg cagccatctg caacccattg ctctattctg catttatgtc taggagagtc 420 tgtatttgct ccattgtgtt ggcatacttc agcggaagta tgacatctat ggtacatgtg 480 tgcctcacat tcaggctgcc attttgtggc tccaatattg ttaatcattt tttctgtgat 540 atcccacctc tcctggcttt atcatgtgca gatacctata tcaacgagct tttgctcttt 600 gccttgtgtg gcttcattca gaccagcact tttgtggtca tatttatctc ttacttctgt 660 attctcctca ctgttttgag cattaagtcc tcagggggca gaagtaaaac attctccact 720 tgtagttccc attttatagc agtcacatta ttctatggaa cactcttgtt tacatattta 780 cgtcccacca ccagctattc cctagacact gacaaggtag ttgcagtgtt ttatactgtt 840 gtcttcccca tgtttaaccc aataatctac agctttagaa acaaggatgt aaagaatgcc 900 ctaaaaaagc tattagaaag aaactggact tttaaatga 939

<210> 774 <211> 312 <212> PRT <213> Canis familiaris <400> 774

Met 1 Trp Glu Ser Asn 5 Tyr Thr Met Pro Thr 10 Glu Phe Leu Leu Val 15 Gly Phe Thr Asp Tyr Leu Pro Leu Arg Val Thr Leu Phe Leu Val Phe Leu 20 25 30 Ile Val Tyr Thr Leu Thr Met Val Gly Asn Met Ser Leu Ile Ile Leu 35 40 45 Val Asn Ile Ser Ser Ser Leu Gln Thr Pro Met Tyr Tyr Leu Leu Ser 50 55 60

Page 869

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Asn 65 Leu Ser Phe Leu Asp Ile Cys Tyr Ser Thr Ala Ile Ala Pro Lys 70 75 80 Met Leu Val Asn Phe Leu Ala Ser Arg Lys Ser Ile Ser Pro Tyr Gly 85 90 95 Cys Ala Leu Gln Met Phe Phe Phe Gly Cys Phe Ala Asp Ala Glu Cys 100 105 110 Leu Ile Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ser Ala Phe Met Ser Arg Arg Val Cys Ile Cys Ser 130 135 140 Ile Val Leu Ala Tyr Phe Ser Gly Ser Met Thr Ser Met Val His Val 145 150 155 160 Cys Leu Thr Phe Arg Leu Pro Phe Cys Gly Ser Asn Ile Val Asn His 165 170 175 Phe Phe Cys Asp Ile Pro Pro Leu Leu Ala Leu Ser Cys Ala Asp Thr 180 185 190 Tyr Ile Asn Glu Leu Leu Leu Phe Ala Leu Cys Gly Phe Ile Gln Thr 195 200 205 Ser Thr Phe Val Val Ile Phe Ile Ser Tyr Phe Cys Ile Leu Leu Thr 210 215 220 Val Leu Ser Ile Lys Ser Ser Gly Gly Arg Ser Lys Thr Phe Ser Thr 225 230 235 240 Cys Ser Ser His Phe Ile Ala Val Thr Leu Phe Tyr Gly Thr Leu Leu 245 250 255 Phe Thr Tyr Leu Arg Pro Thr Thr Ser Tyr Ser Leu Asp Thr Asp Lys 260 265 270

Page 870

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Val Val Ala Val Phe Tyr Thr Val Val Phe Pro Met Phe Asn Pro Ile 275 280 285 Ile Tyr Ser Phe Arg Asn Lys Asp Val Lys Asn Ala Leu Lys Lys Leu 290 295 300 Leu Glu Arg Asn Trp Thr Phe Lys 305 310

<210> 775 <211> 972 <212> DNA <213> Canis familiaris <400> 775

atgaccagaa gaaaccatac ttcactaact gaattcatcc tgttgggatt agcagacaca 60 atggagctac aggtcatcct ctttttgctt tttctggtga tttacacact tactgttttg 120 gggaatgttg ggatgatcct cttaatcagg actgattccc aacttcacac acccatgtat 180 ttcttcctgg ctaacttgtc ctttgtggat gtttgttact cctccaccat caccccaaag 240 atgctggtag acttattgtc agagaagaaa accatctcct ttgctggctg cttcctgcaa 300 ttgtacttct tcatcgcctt ggccacaact gaatgcatcc tctttgggtt aatggcctat 360 gaccgctatg tggccatatg caacccacta ctttactcct tgatcatgtc caggactgtc 420 tgcctcaaaa tggcagcagg ggcttttaca gcaggattct tgaactccat ggttaacaca 480 agttatataa gcagcttgcc attctgcagt tccaatgtca ttcaccactt cttctgtgac 540 agccctccac tttttagact ctcatgttct gacacacgcc tgaatgaaag catcttttcc 600 acatttgctg gtatgaatat ggtcggggct ttgttggtca tcctgacctc ttattcctac 660 attctgtttt caatcttcca tatgcattca ggggagggga agcgcaaagc attctcaacc 720 tgtggctctc acttgacagc tttaactctg ttctatgcca ccgccatcta cacctatctg 780 agacctagtt ccagctactc cctggataag gacaaagtgg cttctgtgtt ctacacagtg 840 gtgatcccca tgttgaatcc tctgatctac agcctcagga atagagaagt aaagaaagct 900 ttatggaatg taactatcag gacaaggatt cccttcattt ctctgatctc cttagtaaat 960

Page 871

069269_0225_SL.TXT tttctgaact ag

972 <210> 776 <211> 323 <212> PRT <213> Canis familiaris <400> 776

Met 1 Thr Arg Arg Asn 5 His Thr Ser Leu Thr Glu Phe Ile Leu Leu Gly 10 15 Leu Ala Asp Thr Met Glu Leu Gln Val Ile Leu Phe Leu Leu Phe Leu 20 25 30 Val Ile Tyr Thr Leu Thr Val Leu Gly Asn Val Gly Met Ile Leu Leu 35 40 45 Ile Arg Thr Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Val Cys Tyr Ser Ser Thr Ile Thr Pro Lys 65 70 75 80 Met Leu Val Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Phe Leu Gln Leu Tyr Phe Phe Ile Ala Leu Ala Thr Thr Glu Cys 100 105 110 Ile Leu Phe Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ser Leu Ile Met Ser Arg Thr Val Cys Leu Lys Met 130 135 140 Ala Ala Gly Ala Phe Thr Ala Gly Phe Leu Asn Ser Met Val Asn Thr 145 150 155 160 Ser Tyr Ile Ser Ser Leu Pro Phe Cys Ser Ser Asn Val Ile His His 165 170 175

Page 872

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Phe Phe Cys Asp Ser Pro Pro Leu Phe Arg Leu Ser Cys Ser Asp Thr 180 185 190 Arg Leu Asn Glu Ser Ile Phe Ser Thr Phe Ala Gly Met Asn Met Val 195 200 205 Gly Ala Leu Leu Val Ile Leu Thr Ser Tyr Ser Tyr Ile Leu Phe Ser 210 215 220 Ile Phe His Met His Ser Gly Glu Gly Lys Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Ala Leu Thr Leu Phe Tyr Ala Thr Ala Ile 245 250 255 Tyr Thr Tyr Leu Arg Pro Ser Ser Ser Tyr Ser Leu Asp Lys Asp Lys 260 265 270 Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Glu Val Lys Lys Ala Leu Trp Asn Val 290 295 300 Thr Ile Arg Thr Arg Ile Pro Phe Ile Ser Leu Ile Ser Leu Val Asn 305 310 315 320

Phe Leu Asn <210> 777 <211> 957 <212> DNA <213> Canis familiaris <400> 777 atggaatcca caggacaaaa tcctctgcag gcgaatcaca ctacattaat ggatttcatc ctggttggtt tttctgatgt tcctaacctc cgaggactac tttttggggt gtttctgata atctatgtga ttattctgat gggtaatagc ctcattatca taataaccaa ggtcaatccc Page 873

120

180

069269_0225_SL.TXT

tccctccaga ctcctatgta ttttttcctt gggaactttt cttccttgga aatatgttat 240 gtgtcggtca ctgtccccag attattaaca gatctttgta gacaaaatag aaatatttct 300 tttctggcct gtgctactca aatgtatttc tttctgatct ttggagccag tgagtgcttc 360 attctgactg caatggctta tgacaggtat gttgccattt gcaacccctt actctatcct 420 ctcatcatga acaacaggct gtgcatccaa ttggcaactg gctgttggat cactggaatt 480 ccagtacaca tagggttcac ctacctcatc ttctctctac acttctgtgg gtccaataag 540 ttgaatcact ttttctgtga catacctcca gtacttaagc ttgcctgtgg ggatacgttc 600 atgattgaaa tgttggttta tgaggttgct gttctagttg tcactattcc ttttttgttg 660 attcttgcat cttatgtgaa aataatctca accatcctga aattgccatc agcagctggg 720 cgagccaagg ccttctccac ttgttcttca catctcatgg ttgtggcttt attctttgga 780 tcaggcatca ttacatactt aagaccaaag tccagtcatt caacaggaat ggacaagttt 840 ctttctcttt tttataccat tgtgacacca atgtttaacc ccataatata ttgtctaaga 900 aacaaagaag ttatggtggc attcaaaaaa tccctaccaa aatggattgt actatga 957 <210> 778 <211> 318 <212> PRT <213> Canis : familiaris <400> 778 Met Glu Ser Thr Gly Gln Asn Pro Leu Gln Ala Asn His Thr Thr Leu 1 5 10 15 Met Asp Phe Ile Leu Val Gly Phe Ser Asp Val Pro Asn Leu Arg Gly 20 25 30 Leu Leu Phe Gly Val Phe Leu Ile Ile Tyr Val Ile Ile Leu Met Gly 35 40 45 Asn Ser Leu Ile Ile Ile Ile Thr Lys Val Asn Pro Ser Leu Gln Thr 50 55 60 Pro Met Tyr Phe Phe Leu Gly Asn Phe Ser Ser Leu Glu Ile Cys Tyr 65 70 75 80

Page 874

069269_0225_SL.TXT

Val Ser Val Thr Val 85 Pro Arg Leu Leu Thr Asp Leu Cys Arg Gln Asn 90 95 Arg Asn Ile Ser Phe Leu Ala Cys Ala Thr Gln Met Tyr Phe Phe Leu 100 105 110 Ile Phe Gly Ala Ser Glu Cys Phe Ile Leu Thr Ala Met Ala Tyr Asp 115 120 125 Arg Tyr Val Ala Ile Cys Asn Pro Leu Leu Tyr Pro Leu Ile Met Asn 130 135 140 Asn Arg Leu Cys Ile Gln Leu Ala Thr Gly Cys Trp Ile Thr Gly Ile 145 150 155 160 Pro Val His Ile Gly Phe Thr Tyr Leu Ile Phe Ser Leu His Phe Cys 165 170 175 Gly Ser Asn Lys Leu Asn His Phe Phe Cys Asp Ile Pro Pro Val Leu 180 185 190 Lys Leu Ala Cys Gly Asp Thr Phe Met Ile Glu Met Leu Val Tyr Glu 195 200 205 Val Ala Val Leu Val Val Thr Ile Pro Phe Leu Leu Ile Leu Ala Ser 210 215 220 Tyr Val Lys Ile Ile Ser Thr Ile Leu Lys Leu Pro Ser Ala Ala Gly 225 230 235 240 Arg Ala Lys Ala Phe Ser Thr Cys Ser Ser His Leu Met Val Val Ala 245 250 255 Leu Phe Phe Gly Ser Gly Ile Ile Thr Tyr Leu Arg Pro Lys Ser Ser 260 265 270 His Ser Thr Gly Met Asp Lys Phe Leu Ser Leu Phe Tyr Thr Ile Val 275 280 285

Page 875

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Thr Pro Met Phe Asn Pro Ile Ile Tyr Cys Leu Arg Asn Lys Glu Val 290 295 300

Met Val Ala Phe Lys Lys Ser Leu Pro Lys Trp Ile Val Leu 305 310 315 <210> 779 <211> 933 <212> DNA <213> Canis familiaris <400> 779

atggaaaatg tgactgaagt caccacgttt atattgacgg gcttcacaga tgattttaaa 60 ctgcaagttt tcctattttt actatttcta gcaatctacc tttttacaat gataggaaat 120 ttgggaatgg ttttattggt ccttggggat tctcggctcc acaaccccat gtattatttt 180 ctgagcgtgt tatcattcct ggatgcctgt tattcttcag ctgttactcc aaaaatgtta 240 gtcaatttcc tagcagagga taaaaccatt tcattccttg gatgtgcagc acagatgttt 300 ctctttattt cttttgggac cacagaatgc tttattttag ctgcaatggc atatgatcgc 360 tacgaagcga tctacaaccc tctcctgtat tcagttcgaa tgtcacccag agtctatgtg 420 ccactcataa tttcctgcta tgtatgtgga ttcctgcatg ctactttaca cactgtggct 480 acttttactc tatccttttg tgcatccaat gaaattagac atgtcttttg tgacatccct 540 cctctccttg ccatttcttg ttctgacacc cacacaaacc agctgctagt cttctacttt 600 gcgggatcta ttgagatatc cactattctg atagtcctgg tctcttatgg tttcattctg 660 gtggccatta tgagggtgca ttctgctgaa gggaggcgga aagtcttttc tacatgtggc 720 tctcacttaa ctggagtgtc aatttttcat ggtacggttc tcttcatgta tgtgagaccc 780 aattccagct atgctttgga tcatgatatg atagtgtcag tattttacac aattgtgatt 840 cccatgctga atcctatcat ctatagtttg aggaacaaag atgtgaaaga tgcagtgaaa 900 agggtatttg gtaaaaactg gtttgccaat taa 933

<210> 780 <211> 310 <212> PRT

Page 876

069269_0225_SL.TXT <213> Canis familiaris <400> 780

Met 1 Glu Asn Val Thr 5 Glu Val Thr Thr Phe Ile Leu Thr Gly Phe Thr 10 15 Asp Asp Phe Lys Leu Gln Val Phe Leu Phe Leu Leu Phe Leu Ala Ile 20 25 30 Tyr Leu Phe Thr Met Ile Gly Asn Leu Gly Met Val Leu Leu Val Leu 35 40 45 Gly Asp Ser Arg Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu 50 55 60 Ser Phe Leu Asp Ala Cys Tyr Ser Ser Ala Val Thr Pro Lys Met Leu 65 70 75 80 Val Asn Phe Leu Ala Glu Asp Lys Thr Ile Ser Phe Leu Gly Cys Ala 85 90 95 Ala Gln Met Phe Leu Phe Ile Ser Phe Gly Thr Thr Glu Cys Phe Ile 100 105 110 Leu Ala Ala Met Ala Tyr Asp Arg Tyr Glu Ala Ile Tyr Asn Pro Leu 115 120 125 Leu Tyr Ser Val Arg Met Ser Pro Arg Val Tyr Val Pro Leu Ile Ile 130 135 140 Ser Cys Tyr Val Cys Gly Phe Leu His Ala Thr Leu His Thr Val Ala 145 150 155 160 Thr Phe Thr Leu Ser Phe Cys Ala Ser Asn Glu Ile Arg His Val Phe 165 170 175 Cys Asp Ile Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Thr 180 185 190 Asn Gln Leu Leu Val Phe Tyr Phe Ala Gly Ser Ile Glu Ile Ser Thr

Page 877

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195 200 205 Ile Leu Ile Val Leu Val Ser Tyr Gly Phe Ile Leu Val Ala Ile Met 210 215 220 Arg Val His Ser Ala Glu Gly Arg Arg Lys Val Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Gly Val Ser Ile Phe His Gly Thr Val Leu Phe Met 245 250 255 Tyr Val Arg Pro Asn Ser Ser Tyr Ala Leu Asp His Asp Met Ile Val 260 265 270 Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Val Lys Arg Val Phe Gly 290 295 300 Lys Asn Trp Phe Ala Asn 305 310

<210> 781 <211> 933 <212> DNA <213> Canis familiaris <400> 781

atggaaaaaa aaacagcaga agtaaatctc acttcgatga cggaatttat tcttttggga 60 ttttctgata ttcccaatct tcaaatgttt ctttttgtag tatttttctt tgtctatgtg 120 ataattttga tgggaaacgg catcattgtt ctcataacca agactgacca ggctctccag 180 actcccatgt attttttcct tagtaatttt tccttcttgg aaatctgttt tgtatctgcc 240 actcttccca aaatgctcac aaacctttgg acccagaaaa gaaatatttc gttgtttgcc 300 tgtgcaacac aaatgtgttt tgtcctcatg cttgggaata tagagtgcct ccttctgatg 360 gtgatggcct atgaccgcta cgttgccatt tgtgaccctc tgcactaccc tctaatcatg 420 aaccacaagg tctgtgttca gcttgtgacc gcctgctgga tcaccggggt tccagtcgag 480

Page 878

069269_0225_SL.TXT

atagggcaga catgccagat cttctctctg ccattttgtg ggtcgagcca aatcaatcac 540 ttcttctgtg acatcccccc actgcttaag ctggcctgtg gggatacttt cctgaatgag 600 atgttagtct ttacagtcgc tgttctcttt gttatgatcc cctttctgtt gatacttgga 660 tcctacagta aaatcatctc taccatcctg aggttgccat ccgcaacagg acgaaccaaa 720 gctttctcca cctgctcatc tcatgtcata gttgtggcca tgttttttgg ttctgcagtc 780 atcacatatt tacgacccaa atccaaacat tcttccagaa cagacaaatt tctttctctt 840 ttctatacca ttgtcacccc aatgtttaat cctatgatat acactctgag aaataaggat 900 gccatgatgg ccttgagaaa attgttgcct taa 933

<210> 782 <211> 310 <212> PRT <213> Canis familiaris <400> 782

Met Glu 1 Lys Lys Thr Ala Glu Val Asn Leu Thr Ser Met Thr Glu Phe 5 10 15 Ile Leu Leu Gly Phe Ser Asp Ile Pro Asn Leu Gln Met Phe Leu Phe 20 25 30 Val Val Phe Phe Phe Val Tyr Val Ile Ile Leu Met Gly Asn Gly Ile 35 40 45 Ile Val Leu Ile Thr Lys Thr Asp Gln Ala Leu Gln Thr Pro Met Tyr 50 55 60 Phe Phe Leu Ser Asn Phe Ser Phe Leu Glu Ile Cys Phe Val Ser Ala 65 70 75 80 Thr Leu Pro Lys Met Leu Thr Asn Leu Trp Thr Gln Lys Arg Asn Ile 85 90 95 Ser Leu Phe Ala Cys Ala Thr Gln Met Cys Phe Val Leu Met Leu Gly 100 105 110

Page 879

Asn Ile Glu 115 Cys Leu Leu Leu 069269_0225_SL.TXT Met Val Met Ala Tyr Asp 120 125 Arg Tyr Val Ala Ile Cys Asp Pro Leu His Tyr Pro Leu Ile Met Asn His Lys Val 130 135 140 Cys Val Gln Leu Val Thr Ala Cys Trp Ile Thr Gly Val Pro Val Glu 145 150 155 160 Ile Gly Gln Thr Cys Gln Ile Phe Ser Leu Pro Phe Cys Gly Ser Ser 165 170 175 Gln Ile Asn His Phe Phe Cys Asp Ile Pro Pro Leu Leu Lys Leu Ala 180 185 190 Cys Gly Asp Thr Phe Leu Asn Glu Met Leu Val Phe Thr Val Ala Val 195 200 205 Leu Phe Val Met Ile Pro Phe Leu Leu Ile Leu Gly Ser Tyr Ser Lys 210 215 220 Ile Ile Ser Thr Ile Leu Arg Leu Pro Ser Ala Thr Gly Arg Thr Lys 225 230 235 240 Ala Phe Ser Thr Cys Ser Ser His Val Ile Val Val Ala Met Phe Phe 245 250 255 Gly Ser Ala Val Ile Thr Tyr Leu Arg Pro Lys Ser Lys His Ser Ser 260 265 270 Arg Thr Asp Lys Phe Leu Ser Leu Phe Tyr Thr Ile Val Thr Pro Met 275 280 285 Phe Asn Pro Met Ile Tyr Thr Leu Arg Asn Lys Asp Ala Met Met Ala 290 295 300 Leu Arg Lys Leu Leu Pro 305 310

Page 880

069269_0225_SL.TXT <210> 783 <211> 951 <212> DNA <213> Canis familiaris <400> 783

atggagaaca cattaaaaac agaaaatttt aatgttacta ccattgtgga atttgttctc 60 ttggggtttt ctgatattcc caatctccaa tggattcttt ttgggatatt tttagtcatc 120 tacctaacta tactgatgtg taatagcatc ataatattga taataagaat tgaccctgct 180 ctccagaccc ccatgtattt ttttcttagc aatttttcct tcttagaaat ctgttatgta 240 acagtcacta tcccaagaat gctcatggac ctattgaccc agaaaggaaa tatttctttc 300 tttgcctgtg ctgcacaaat gtgttttgtc cttatgtttg gaggctcaga atgtcttctc 360 ctgacagtga tggcctatga tcgctacgtg gccatttgta accctctgca ttaccctctc 420 gtcatgaacc acaaggtctg tgtccagctg gtgactgttg cctggatcag tggagtacca 480 gttgtgattg gacaaacatg ccagattttc tctctgccct tctgtgggtc taacacaatt 540 aatcatttct tctgtgacct tcccccagta ctcaagcttg cttgtgggga cacatttttg 600 aacgagatag cagtctatgt tgttgcagtg gtcttcgtca tgattccttt tctgttgatt 660 gttgtttcct atggcaaaat catctccaac attctgaaat tgtcaacagc caaaggaagg 720 gctaaagcct tctccacctg ttcttctcac ctgatagttg tagtcttatt ctatggaaca 780 gctactatca cttatttaca acccaaacca aatcaatctg aaggagttgg gaaattgatt 840 tctcttttct ataccatttt gatcccaaca ttgaatcccc ttatatatac tctgaggaac 900 aaagatatca tggtagcact gagaaaacta ctaacgaagt tattaccgtg a 951

<210> 784 <211> 316 <212> PRT <213> Canis familiaris <400> 784

Met Glu Asn Thr Leu Lys Thr Glu Asn Phe Asn Val Thr Thr Ile Val 1 5 10 15

Glu Phe Val Leu Leu Gly Phe Ser Asp Ile Pro Asn Leu Gln Trp Ile 20 25 30

Page 881

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Leu Phe Gly 35 Ile Phe Leu Val Ile Tyr Leu Thr Ile Leu Met Cys Asn 40 45 Ser Ile Ile Ile Leu Ile Ile Arg Ile Asp Pro Ala Leu Gln Thr Pro 50 55 60 Met Tyr Phe Phe Leu Ser Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val 65 70 75 80 Thr Val Thr Ile Pro Arg Met Leu Met Asp Leu Leu Thr Gln Lys Gly 85 90 95 Asn Ile Ser Phe Phe Ala Cys Ala Ala Gln Met Cys Phe Val Leu Met 100 105 110 Phe Gly Gly Ser Glu Cys Leu Leu Leu Thr Val Met Ala Tyr Asp Arg 115 120 125 Tyr Val Ala Ile Cys Asn Pro Leu His Tyr Pro Leu Val Met Asn His 130 135 140 Lys Val Cys Val Gln Leu Val Thr Val Ala Trp Ile Ser Gly Val Pro 145 150 155 160 Val Val Ile Gly Gln Thr Cys Gln Ile Phe Ser Leu Pro Phe Cys Gly 165 170 175 Ser Asn Thr Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Lys 180 185 190 Leu Ala Cys Gly Asp Thr Phe Leu Asn Glu Ile Ala Val Tyr Val Val 195 200 205 Ala Val Val Phe Val Met Ile Pro Phe Leu Leu Ile Val Val Ser Tyr 210 215 220 Gly Lys Ile Ile Ser Asn Ile Leu Lys Leu Ser Thr Ala Lys Gly Arg 225 230 235 240

Page 882

069269_0225_SL.TXT

Ala Lys Ala Phe Ser Thr Cys Ser Ser His Leu Ile Val Val Val 255 Leu 245 250 Phe Tyr Gly Thr Ala Thr Ile Thr Tyr Leu Gln Pro Lys Pro Asn Gln 260 265 270 Ser Glu Gly Val Gly Lys Leu Ile Ser Leu Phe Tyr Thr Ile Leu Ile 275 280 285 Pro Thr Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Ile Met 290 295 300 Val Ala Leu Arg Lys Leu Leu Thr Lys Leu Leu Pro

305 310 315 <210> 785 <211> 795 <212> DNA <213> Canis familiaris <400> 785

tttctcatct acataataat ctttatggca aatggcatca ttattctcat aactagaatt 60 ggccagcctg ttaatttttt ccttagtaat ttttctttcc tgaaaatatt ttatgtattt 120 gtcattcttt ctagaatgct cctaaacctt tggactcaga aaagaaacat ttctttttct 180 gcctgtgtta caaaaatatg ttttctcttt atgcttggaa acatggaatg ctttctcccg 240 atagcgttgg cctatgacca ctacatggcc atttgtcatg ttccatcctg tcctccagtt 300 atgaaccaca agctccatgt ccagctgaca ttgactggct tttggatcag tagagttcca 360 gtcaaaatag ggtagacatg ccagattttc tctctgccat tttgtgagtc taaccaaatc 420 agctacttgt tctgagacat ccctgtacta ctcaagctgg cccgtgggga cactttcctg 480 gatgggatgt tagcttttat agttactgtg ctttttatta ttattctttt ttcactgata 540 cttggatcct atagtaaaat tatcccctct atcttgaagt tgctgttggc aacaagacca 600 gccaaagctt tatccactta ctcatctcac atcatagttg tagcttgatt ctctggatcc 660 caaattgtta catatttatg acccaaatcc aaatatattt ttcagaatag actaatttat 720 ttctctttct gtataccatt gtcattatga tgtttaaacc catgcatgat atatactcta 780

Page 883

069269_0225_SL.TXT

aggagtaaag attca 795 <210> 786 <211> 124 <212> PRT <213> Canis familiaris <400> 786 Phe Leu Ile Tyr Ile Ile Ile Phe Met Ala Asn Gly Ile Ile Ile Leu 1 5 10 15 Ile Thr Arg Ile Gly Gln Pro Val Asn Phe Phe Leu Ser Asn Phe Ser 20 25 30 Phe Leu Lys Ile Phe Tyr Val Phe Val Ile Leu Ser Arg Met Leu Leu 35 40 45 Asn Leu Trp Thr Gln Lys Arg Asn Ile Ser Phe Ser Ala Cys Val Thr 50 55 60 Lys Ile Cys Phe Leu Phe Met Leu Gly Asn Met Glu Cys Phe Leu Pro 65 70 75 80 Ile Ala Leu Ala Tyr Asp His Tyr Met Ala Ile Cys His Val Pro Ser 85 90 95 Cys Pro Pro Val Met Asn His Lys Leu His Val Gln Leu Thr Leu Thr 100 105 110 Gly Phe Trp Ile Ser Arg Val Pro Val Lys Ile Gly

115 120 <210> 787 <211> 945 <212> DNA <213> Canis familiaris <400> 787 atggctgatg gaaaccatac aagaatcaca gaatttattt tcataggctt gaagtatcat 60 cctcggatgc aagtcttcct tttcttgctc tttctacttt tttactttgt taccgtgaca 120

Page 884

069269_0225_SL.TXT

ggaaacttgg gtatgattat tctcatccag atggattccc gccttcacac acccatgtac 180 ttttttctca gtcacctgtc tttcgtggac atctgctttt cttcagttgt gggtcccaag 240 atgctcaccg acttcttcgc tgaaaagaag gccatctcct tcctgggctg tgctttgcag 300 caatggttct ttggattctt tgtggccatt gagtgtcttc tgctggcatc catggcctat 360 gatcgctatg ttgccatctg taacccatta ttatattctg ttgccatgtc acagagactc 420 tgcatacagc tggtggttgg accctacact gttgggtttc tgagcaccat gactcacacc 480 acggctgctt tccgacttcc cttttgtggc tccaacatta tcaatcattt cttctgtgac 540 atgtcccccc ttctttcttt ggtatgtgct gacacccgga tcaataaatt gttagttttc 600 attgtggctg gagccgtact ggttgtcagt agcctgacca ttataatctc ctatttttac 660 atccttactg ccatcctgag gatccgttct gccgatggga ggcgcaaagc cttttccacc 720 tgttcctccc acctcaccgc ggtgtccatc ttatacggga cactcttctt tatctacgtg 780 aggccaggtg caattttttc cctggatgtc aataaagtgg tctcagtgtt ctacacagca 840 gtgatcccca tgttgaatcc tctcatctac agcttgagaa ataaagaagt gaaagctgcc 900 atgcacagaa tgatcatcag gaggaagttt tgcatcagaa gttaa <210> 788 <211> 314 <212> PRT <213> Canis familiaris <400> 788 945 Met Ala Asp Gly Asn His Thr Arg Ile Thr Glu Phe Ile Phe Ile Gly 1 5 10 15 Leu Lys Tyr His Pro Arg Met Gln Val Phe Leu Phe Leu Leu Phe Leu 20 25 30 Leu Phe Tyr Phe Val Thr Val Thr Gly Asn Leu Gly Met Ile Ile Leu 35 40 45 Ile Gln Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Ile Cys Phe Ser Ser Val Val Gly Pro Lys

Page 885

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Met Leu Thr Asp Phe 85 Phe Ala Glu Lys Lys Ala Ile Ser Phe Leu Gly 90 95 Cys Ala Leu Gln Gln Trp Phe Phe Gly Phe Phe Val Ala Ile Glu Cys 100 105 110 Leu Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ser Val Ala Met Ser Gln Arg Leu Cys Ile Gln Leu 130 135 140 Val Val Gly Pro Tyr Thr Val Gly Phe Leu Ser Thr Met Thr His Thr 145 150 155 160 Thr Ala Ala Phe Arg Leu Pro Phe Cys Gly Ser Asn Ile Ile Asn His 165 170 175 Phe Phe Cys Asp Met Ser Pro Leu Leu Ser Leu Val Cys Ala Asp Thr 180 185 190 Arg Ile Asn Lys Leu Leu Val Phe Ile Val Ala Gly Ala Val Leu Val 195 200 205 Val Ser Ser Leu Thr Ile Ile Ile Ser Tyr Phe Tyr Ile Leu Thr Ala 210 215 220 Ile Leu Arg Ile Arg Ser Ala Asp Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ser Ile Leu Tyr Gly Thr Leu Phe 245 250 255 Phe Ile Tyr Val Arg Pro Gly Ala Ile Phe Ser Leu Asp Val Asn Lys 260 265 270 Val Val Ser Val Phe Tyr Thr Ala Val Ile Pro Met Leu Asn Pro Leu

Page 886

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275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Met His Arg Met 290 295 300 Ile Ile Arg Arg Lys Phe Cys Ile Arg Ser 305 310

<210> 789 <211> 942 <212> DNA <213> Canis familiaris <400> 789

atgaaacacc aagaaaaacc accagaagat aatctaactg aactgataga atttgttctc 60 ttggactttg ctgatgttcc ccatctccag tggcttctat ttggactgtt cttagtcatc 120 tacatcatta ttgtgatgag taatggcatc atttttctaa taacaaaact ggacccttct 180 ctccagaccc ctatgtactt tttcctaggc aatttttcct ttttggaaat ctgctatgta 240 tcagttactc tccccagaat gctcatgaac ctttggaccc agagaagaac aatttcttta 300 gttgcctgtg ctacccaaat gtgctgcatt cttgtgctgg gaaccactga atgtttcctt 360 ctagcagtga tggcctatga tcgctacatg gccatttgca accctctaca ctacccttta 420 atgatgaacc aaaaaacttg tattcagctg gcggctggct cctggatcag tggaattcca 480 gtccagatag ggcaaacagt ccagattttc tctctgccct tttgtggctc taatttaatt 540 gaccacttct tctgtgacat ccccccagta ctcaagcttg cttgtgggaa cacatttgtg 600 aatgaaatga tggtctacat agttgccgtg ttgattgtca cagttccatt tctgttgata 660 cttatttcct atggcaaaat catctccaca atccttaaat tgcattcagc cacaagtcgg 720 gccaaagcct tctccacctg ttcatctcat cttacagttg tggtgttgtt ctttggatca 780 gccattatta cctatttaag acccaaagcc agtcactcag caagaattga caaagtgctt 840 tctcttttct acacagttgt gactcccatg tttaatcctc tcatatacag tctaaggaac 900 aaggaagtca taacagcttt gagaaaattg ctatgtaaat aa 942

<210> 790 <211> 313

Page 887

069269_0225_SL.TXT <212> PRT <213> Canis familiaris <400> 790

Met 1 Lys His Gln Glu Lys Pro 5 Pro Glu Asp Asn Leu Thr Glu Leu Ile 10 15 Glu Phe Val Leu Leu Asp Phe Ala Asp Val Pro His Leu Gln Trp Leu 20 25 30 Leu Phe Gly Leu Phe Leu Val Ile Tyr Ile Ile Ile Val Met Ser Asn 35 40 45 Gly Ile Ile Phe Leu Ile Thr Lys Leu Asp Pro Ser Leu Gln Thr Pro 50 55 60 Met Tyr Phe Phe Leu Gly Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val 65 70 75 80 Ser Val Thr Leu Pro Arg Met Leu Met Asn Leu Trp Thr Gln Arg Arg 85 90 95 Thr Ile Ser Leu Val Ala Cys Ala Thr Gln Met Cys Cys Ile Leu Val 100 105 110 Leu Gly Thr Thr Glu Cys Phe Leu Leu Ala Val Met Ala Tyr Asp Arg 115 120 125 Tyr Met Ala Ile Cys Asn Pro Leu His Tyr Pro Leu Met Met Asn Gln 130 135 140 Lys Thr Cys Ile Gln Leu Ala Ala Gly Ser Trp Ile Ser Gly Ile Pro 145 150 155 160 Val Gln Ile Gly Gln Thr Val Gln Ile Phe Ser Leu Pro Phe Cys Gly 165 170 175 Ser Asn Leu Ile Asp His Phe Phe Cys Asp Ile Pro Pro Val Leu Lys 180 185 190

Page 888

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Leu Ala Cys Gly Asn Thr Phe Val Asn Glu Met Met Val Tyr Ile Val 195 200 205 Ala Val Leu Ile Val Thr Val Pro Phe Leu Leu Ile Leu Ile Ser Tyr 210 215 220 Gly Lys Ile Ile Ser Thr Ile Leu Lys Leu His Ser Ala Thr Ser Arg 225 230 235 240 Ala Lys Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Val Leu 245 250 255 Phe Phe Gly Ser Ala Ile Ile Thr Tyr Leu Arg Pro Lys Ala Ser His 260 265 270 Ser Ala Arg Ile Asp Lys Val Leu Ser Leu Phe Tyr Thr Val Val Thr 275 280 285 Pro Met Phe Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile 290 295 300 Thr Ala Leu Arg Lys Leu Leu Cys Lys

305 310 <210> 791 <211> 951 <212> DNA <213> Canis familiaris <400> 791

atgctaccca gagaccaaac tacagaaggc aatttgtctt cagttgtggc atttgttctc 60 ctgggatttt ctgaccttcc taacatccag ggatttctat ttggaatttt ctttctcatc 120 tacatgtcca tcttaatagg aaatggtctt atcataataa ttacaagggt agactctgtt 180 ctccagacac ccatgtattt tttcattgca aatttttcct ccctggaaat ctgttatgtg 240 tctgtcaccc tccccaggat tctggtgaat ctttggactc aggacagaag catttcttgg 300 ttgggctgtg ccactcaaat gtgcttcttc ctcatgctgg gagccactga atgtttcctc 360 ttggcagtga tggcctatga ccgctacgtg gccatttgta accctctgca ctaccctctc 420

Page 889

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atcatgaacc acaagatgtg cgtccaactg gctgttggtg cctggcttag tggaattcca 480 gtccagatag gacaaacatg tcaggtgttc tcgctgcctt tctgtggttc taaccaaatt 540 aaccacttct tctgtgacat ccccccattg atcaagctgg cttgtgggga cacttcactt 600 aatgagatgt gtgtctttgt agttgctata ttatttgtca tgattccttt tctatttata 660 cttggctctt atgtgaaaat catttccacc atcctaaagt tgtcctcagc caggggccgg 720 tctaaagcct tctccacctg ttcttcccat atcattgttg tgcttttatt ctttggatcg 780 gctaccatca cctacttaag gcccaaatcc aatcattctg caagaactga caagatgctc 840 tctcttttct acaccattgt gactcctatg tttaaccctc tgatatacag tcttaggaac 900 aaggatgtga agacagcact gaaaaaatta ttactcaaga aaacagtgta a 951

<210> 792 <211> 316 <212> PRT <213> Canis familiaris <400> 792

Met Leu Pro Arg Asp Gln Thr Thr Glu Gly Asn Leu Ser Ser Val Val 1 5 10 15 Ala Phe Val Leu Leu Gly Phe Ser Asp Leu Pro Asn Ile Gln Gly Phe 20 25 30 Leu Phe Gly Ile Phe Phe Leu Ile Tyr Met Ser Ile Leu Ile Gly Asn 35 40 45 Gly Leu Ile Ile Ile Ile Thr Arg Val Asp Ser Val Leu Gln Thr Pro 50 55 60 Met Tyr Phe Phe Ile Ala Asn Phe Ser Ser Leu Glu Ile Cys Tyr Val 65 70 75 80 Ser Val Thr Leu Pro Arg Ile Leu Val Asn Leu Trp Thr Gln Asp Arg 85 90 95 Ser Ile Ser Trp Leu Gly Cys Ala Thr Gln Met Cys Phe Phe Leu Met 100 105 110

Page 890

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Leu Gly Ala 115 Thr Glu Cys Phe Leu Leu Ala Val Met Ala Tyr Asp Arg 120 125 Tyr Val Ala Ile Cys Asn Pro Leu His Tyr Pro Leu Ile Met Asn His 130 135 140 Lys Met Cys Val Gln Leu Ala Val Gly Ala Trp Leu Ser Gly Ile Pro 145 150 155 160 Val Gln Ile Gly Gln Thr Cys Gln Val Phe Ser Leu Pro Phe Cys Gly 165 170 175 Ser Asn Gln Ile Asn His Phe Phe Cys Asp Ile Pro Pro Leu Ile Lys 180 185 190 Leu Ala Cys Gly Asp Thr Ser Leu Asn Glu Met Cys Val Phe Val Val 195 200 205 Ala Ile Leu Phe Val Met Ile Pro Phe Leu Phe Ile Leu Gly Ser Tyr 210 215 220 Val Lys Ile Ile Ser Thr Ile Leu Lys Leu Ser Ser Ala Arg Gly Arg 225 230 235 240 Ser Lys Ala Phe Ser Thr Cys Ser Ser His Ile Ile Val Val Leu Leu 245 250 255 Phe Phe Gly Ser Ala Thr Ile Thr Tyr Leu Arg Pro Lys Ser Asn His 260 265 270 Ser Ala Arg Thr Asp Lys Met Leu Ser Leu Phe Tyr Thr Ile Val Thr 275 280 285 Pro Met Phe Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Thr Ala Leu Lys Lys Leu Leu Leu Lys Lys Thr Val

305 310 315

Page 891

069269_0225_SL.TXT <210> 793 <211> 936 <212> DNA <213> Canis familiaris <400> 793

atgagagcag aagacaatgg ttccacaata acacaatttg tactcttggg attttctgac 60 cttccaaacc tccaagggtt tctatttggg gtgttctcca tcgtttatgt tattatctta 120 attggaaata gcctcataat aataataacc agtcttgatg ctgcactcca gaaacccatg 180 tattttttcc tggcaaattt ttcctccttg gaaatctgtt atgtgtctgt caccctcccc 240 aggattctgg tgaacctttg gactcaggac agaagcattt cttggttggg ctgtgccact 300 caaatgtgct tcttcctcat gctgggagcc actgaatgtt tcctcttggc agtgatggcc 360 tatgaccgct acgtggccat ttgtaaccct ctgcactacc ctctcatcgt gaaccacaag 420 atgtgcgtcc aactggctgt tggtgcctgg cttagtggaa ttccagtcca gataggacaa 480 acatgtcagg tgttctcgct gcctttctgt ggttctaacc aaattaacca cttcttctgt 540 gacatccccc cattgatcaa gctggcttgt ggggacactt cacttaatga gatgtgtgtc 600 tttgtagttg ctatattatt tgcaatgatt ccctttctat ttatacttgg ctcttatgtg 660 aaaatcattt ccaccatcct aaagttatcc tcagccaggg gccggtctaa agccttctcc 720 acctgttctt cccatatcat tgttgtgctt ttattctttg gatcggctac catcacctac 780 ttaaggccca aatccattca ttctgctgga actgacaaaa tgttgtctct tctctatacc 840 attgtgactc cgatgtttaa tcctatgata tacagtctta ggaacaagga tgtgattgca 900 gcactcagaa gactgttact taaaaaaata gtgtga 936

<210> 794 <211> 311 <212> PRT <213> Canis familiaris <400> 794

Met Arg Ala Glu Asp Asn Gly Ser Thr Ile Thr Gln Phe Val Leu Leu

1 5 10 15

Gly Phe Ser Asp Leu Pro Asn Leu Gln Gly Phe Leu Phe Gly Val Phe

20 25 30

Page 892

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Ser Ile Val 35 Tyr Val Ile Ile Leu Ile Gly Asn Ser Leu Ile Ile Ile 40 45 Ile Thr Ser Leu Asp Ala Ala Leu Gln Lys Pro Met Tyr Phe Phe Leu 50 55 60 Ala Asn Phe Ser Ser Leu Glu Ile Cys Tyr Val Ser Val Thr Leu Pro 65 70 75 80 Arg Ile Leu Val Asn Leu Trp Thr Gln Asp Arg Ser Ile Ser Trp Leu 85 90 95 Gly Cys Ala Thr Gln Met Cys Phe Phe Leu Met Leu Gly Ala Thr Glu 100 105 110 Cys Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu His Tyr Pro Leu Ile Val Asn His Lys Met Cys Val Gln 130 135 140 Leu Ala Val Gly Ala Trp Leu Ser Gly Ile Pro Val Gln Ile Gly Gln 145 150 155 160 Thr Cys Gln Val Phe Ser Leu Pro Phe Cys Gly Ser Asn Gln Ile Asn 165 170 175 His Phe Phe Cys Asp Ile Pro Pro Leu Ile Lys Leu Ala Cys Gly Asp 180 185 190 Thr Ser Leu Asn Glu Met Cys Val Phe Val Val Ala Ile Leu Phe Ala 195 200 205 Met Ile Pro Phe Leu Phe Ile Leu Gly Ser Tyr Val Lys Ile Ile Ser 210 215 220 Thr Ile Leu Lys Leu Ser Ser Ala Arg Gly Arg Ser Lys Ala Phe Ser 225 230 235 240

Page 893

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Thr Cys Ser Ser His Ile Ile Val Val Leu Leu Phe Phe Gly Ser Ala 245 250 255 Thr Ile Thr Tyr Leu Arg Pro Lys Ser Ile His Ser Ala Gly Thr Asp 260 265 270 Lys Met Leu Ser Leu Leu Tyr Thr Ile Val Thr Pro Met Phe Asn Pro 275 280 285 Met Ile Tyr Ser Leu Arg Asn Lys Asp Val Ile Ala Ala Leu Arg Arg 290 295 300 Leu Leu Leu Lys Lys Ile Val

305 310 <210> 795 <211> 945 <212> DNA <213> Canis familiaris <400> 795 atggaattga tggatggaaa ctacaccttg gtgaccgagt ttattctttt agggtttccg acccgccctg aactgcagat tgtcctattc ctcgtgtttc tgacattgta tggtataatt ttaacaggga atattggatt gatgatgtta atcaggaccg accctcacct tcaaacccct atgtattttt tccttagcaa cctctccttt gcagaccttt gtttctcctc agccattgtt cccaagatgt tggtcaattt cctctcagaa aataaatcta tctcccttta tggctgtgcc ctacagtttt atttttcctg tgcttttgct gatacagaat cctttatcct ggctgccatg gcatacgatc gctatgttgc catctgtaat cctttactgt atacagttgt gatgtctcgg ggcatctgtg tatggttgat tgtcttgtcc tacattggag gtaacatgag ttccctggtt cacacgtcct ttgcctttat tctgaaatac tgcgataaaa atgtcattaa tcattttttc tgcgacctcc ctcccctgct taagctatcc tgcacagaca cctcagttaa tgagtggctt ctctccacat atggcagctc agtggaaatt ttctgcttca tcgtcattgt catctcctac tatttcattc tgcgctcagt cttgaggatc cgctcttcca gtggcagaaa gaaaaccttc

120

180

240

300

360

420

480

540

600

660

720

Page 894

069269_0225_SL.TXT tccacgtgtg cctctcacct gacttctgtg gccatctatc aggggactct tctcttcatt tactcacggc ccacctatct gtatactccc aacactgata aaattatctc cgtgttctac accattatta tcccagtgct gaatccgttg atttatagtt tgagaaataa agatgtaaaa gatgccgcta agagagctgt aaggttaaaa gtggattcct catga

780

840

900

945 <210> 796 <211> 314 <212> PRT <213> Canis familiaris <400> 796

Met Glu Leu Met Asp Gly Asn Tyr Thr Leu Val Thr Glu Phe Ile Leu 1 5 10 15 Leu Gly Phe Pro Thr Arg Pro Glu Leu Gln Ile Val Leu Phe Leu Val 20 25 30 Phe Leu Thr Leu Tyr Gly Ile Ile Leu Thr Gly Asn Ile Gly Leu Met 35 40 45 Met Leu Ile Arg Thr Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ser Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Ser Ala Ile Val 65 70 75 80 Pro Lys Met Leu Val Asn Phe Leu Ser Glu Asn Lys Ser Ile Ser Leu 85 90 95 Tyr Gly Cys Ala Leu Gln Phe Tyr Phe Ser Cys Ala Phe Ala Asp Thr 100 105 110 Glu Ser Phe Ile Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Leu Tyr Thr Val Val Met Ser Arg Gly Ile Cys Val 130 135 140 Trp Leu Ile Val Leu Ser Tyr Ile Gly Gly Asn Met Ser Ser Leu Val

Page 895

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145 150 155 160 His Thr Ser Phe Ala Phe Ile Leu Lys Tyr Cys Asp Lys Asn Val Ile 165 170 175 Asn His Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ser Cys Thr 180 185 190 Asp Thr Ser Val Asn Glu Trp Leu Leu Ser Thr Tyr Gly Ser Ser Val 195 200 205 Glu Ile Phe Cys Phe Ile Val Ile Val Ile Ser Tyr Tyr Phe Ile Leu 210 215 220 Arg Ser Val Leu Arg Ile Arg Ser Ser Ser Gly Arg Lys Lys Thr Phe 225 230 235 240 Ser Thr Cys Ala Ser His Leu Thr Ser Val Ala Ile Tyr Gln Gly Thr 245 250 255 Leu Leu Phe Ile Tyr Ser Arg Pro Thr Tyr Leu Tyr Thr Pro Asn Thr 260 265 270 Asp Lys Ile Ile Ser Val Phe Tyr Thr Ile Ile Ile Pro Val Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Ala Lys 290 295 300 Arg Ala Val Arg Leu Lys Val Asp Ser Ser 305 310

<210> 797 <211> 705 <212> DNA <213> Canis familiaris <220>

<221> modified_base <222> (705)..(705)

Page 896

069269_0225_SL.TXT <223> a, c, t, g, unknown or other <400> 797 atgagagcag aagacaatgg ttccagaata acacaatttg tactcttggg attttctgac 60 cttccaaacc tccaagggtt actatttggg gtgttctcca tcatttatgt tattatctta 120 attggaaata gcctcataat aataataacc agtcttgatg ctgcactcca gaaacccatg 180 tattttttcc tggcaaattt ttcctacttg gaaatctgtt atgtgtctgt caccctcccc 240 aggattctgg tgaacctttg gactcaggac agaagtattt cttggttggg ctgtgccact 300 caaatgtgct ttttccttat gctgggagcc actgaatgtt tcctcctggc tgtgatggcc 360 tatgaccgct acgtggccat ttgtaaccct ctgcactacc ctctcatcat gaaccacaag 420 atgtgcatcc aactggctgt tgggtcctgg attggtggag tcccaggcca aataggacaa 480 acatggcaga ttttctctct acatttctgt aattctaacc aaatcaacca cttcttctgt 540 gacatacctc ccatcctcaa gctagcctgt ggggacactg ttgtgcatga gatagcagtc 600 tatgtactag ctgtgttgtt tgttgcagtt cattttctgt taatacttgc ctcttacagc 660 aaaatcattt caaacattct gaggttgcca acagccagag gacgn 705 <210> 798 <211> 235 <212> PRT <213> Canis familiaris <400> 798

Met Arg Ala Glu Asp Asn Gly Ser Arg Ile Thr Gln Phe Val Leu Leu 1 5 10 15 Gly Phe Ser Asp Leu Pro Asn Leu Gln Gly Leu Leu Phe Gly Val Phe 20 25 30 Ser Ile Ile Tyr Val Ile Ile Leu Ile Gly Asn Ser Leu Ile Ile Ile 35 40 45 Ile Thr Ser Leu Asp Ala Ala Leu Gln Lys Pro Met Tyr Phe Phe Leu 50 55 60 Ala Asn Phe Ser Tyr Leu Glu Ile Cys Tyr Val Ser Val Thr Leu Pro 65 70 75 80

Page 897

069269_0225_SL.TXT

Arg Ile Leu Val Asn Leu Trp Thr Gln Asp Arg Ser Ile Ser Trp Leu 85 90 95 Gly Cys Ala Thr Gln Met Cys Phe Phe Leu Met Leu Gly Ala Thr Glu 100 105 110 Cys Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu His Tyr Pro Leu Ile Met Asn His Lys Met Cys Ile Gln 130 135 140 Leu Ala Val Gly Ser Trp Ile Gly Gly Val Pro Gly Gln Ile Gly Gln 145 150 155 160 Thr Trp Gln Ile Phe Ser Leu His Phe Cys Asn Ser Asn Gln Ile Asn 165 170 175 His Phe Phe Cys Asp Ile Pro Pro Ile Leu Lys Leu Ala Cys Gly Asp 180 185 190 Thr Val Val His Glu Ile Ala Val Tyr Val Leu Ala Val Leu Phe Val 195 200 205 Ala Val His Phe Leu Leu Ile Leu Ala Ser Tyr Ser Lys Ile Ile Ser 210 215 220 Asn Ile Leu Arg Leu Pro Thr Ala Arg Gly Arg 225 230 235

<210> 799 <211> 945 <212> DNA <213> Canis familiaris <400> 799 atggaattga tggatggaaa ctacaccttg gtgactgagt ttattctttt agggtttccg acccgccctg aactgcagat tgtcctattc ctcatgtttc tgacattgta tggtatgatt

120

Page 898

069269_0225_SL.TXT

ttaacaggga atattggact gatgatgtta atcaggacag accctcacct tcaaacccct 180 atgtattttt tccttagcaa cctctccttt gcagatcttt gttactcatc agtcattgtt 240 cccaaaatgc tggtcaattt cctctcagaa aataaatcta tctcctatta tggctgtgcc 300 ctacagtttt attttttctg tgcttttgct gatacagaat cctttatcct ggctgccatg 360 gcatacgatc gctatgttgc catctgtaat cctttactgt atacagttgt gatgtctcgg 420 ggcatctgtg tatggttgat tgtcttgtcc tacattggag gtaacatgag ttccctggtt 480 cacacgtcct ttgcctttat tttgaaatac tgcgataaaa atgtcattaa tcattttttc 540 tgcgacctcc ctcccctgct taagctatcc tgcacagaca cctcagttaa tgagtggctt 600 ctctccacat atggcagctc agtggaaatt atctgcttca tcgtcattgt catctcctac 660 tatttcattc tgcgctcagt cttgaggatc cgctcttcca gtggcagaaa gaaaaccttc 720 tccacgtgtg cctctcacct gacttctgtg gccatctatc aggggactct tctcttcatt 780 tactcacggc ccagctatct gtattctccc aacactgata aaattatctc cgtgttctac 840 accattatta tcccagtgct gaatccattg atttatagtt tgagaaataa agatgtaaaa 900 gatgccgcta agagagctgt aaggttaaaa gtggattcct catga 945

<210> 800 <211> 314 <212> PRT <213> Canis familiaris <400> 800

Met 1 Glu Leu Met Asp Gly Asn Tyr Thr Leu Val Thr Glu Phe Ile Leu 5 10 15 Leu Gly Phe Pro Thr Arg Pro Glu Leu Gln Ile Val Leu Phe Leu Met 20 25 30 Phe Leu Thr Leu Tyr Gly Met Ile Leu Thr Gly Asn Ile Gly Leu Met 35 40 45 Met Leu Ile Arg Thr Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ser Asn Leu Ser Phe Ala Asp Leu Cys Tyr Ser Ser Val Ile Val

Page 899

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Pro Lys Met Leu Val 85 Asn Phe Leu Ser Glu Asn Lys Ser Ile Ser Tyr 90 95 Tyr Gly Cys Ala Leu Gln Phe Tyr Phe Phe Cys Ala Phe Ala Asp Thr 100 105 110 Glu Ser Phe Ile Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Leu Tyr Thr Val Val Met Ser Arg Gly Ile Cys Val 130 135 140 Trp Leu Ile Val Leu Ser Tyr Ile Gly Gly Asn Met Ser Ser Leu Val 145 150 155 160 His Thr Ser Phe Ala Phe Ile Leu Lys Tyr Cys Asp Lys Asn Val Ile 165 170 175 Asn His Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ser Cys Thr 180 185 190 Asp Thr Ser Val Asn Glu Trp Leu Leu Ser Thr Tyr Gly Ser Ser Val 195 200 205 Glu Ile Ile Cys Phe Ile Val Ile Val Ile Ser Tyr Tyr Phe Ile Leu 210 215 220 Arg Ser Val Leu Arg Ile Arg Ser Ser Ser Gly Arg Lys Lys Thr Phe 225 230 235 240 Ser Thr Cys Ala Ser His Leu Thr Ser Val Ala Ile Tyr Gln Gly Thr 245 250 255 Leu Leu Phe Ile Tyr Ser Arg Pro Ser Tyr Leu Tyr Ser Pro Asn Thr 260 265 270 Asp Lys Ile Ile Ser Val Phe Tyr Thr Ile Ile Ile Pro Val Leu Asn

Page 900

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275 280 285 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Ala Lys 290 295 300 Arg Ala Val Arg Leu Lys Val Asp Ser Ser 305 310

<210> 801 <211> 933 <212> DNA <213> Canis familiaris <400> 801

atggataaag gaaattgctc atccttgaca gaattcattt tcttgggaat taccaataac 60 cctggaatga aagtgaccct atttgcaacg tttcttgttg tttatctcat taatctgttt 120 gcaaatcttg gaatgattat tttaattata atagattccc agcttcacac accaatgtac 180 tttttcctta gtcaactctc tttctgtgac ctctgctatt ctacagcggt tgggcccaaa 240 atgttggtag accttttagc taaaaacaaa tcaatcccct tctttgggtg tgcccttcaa 300 ttcttgatct tctgtatgtt tgctgattct gagtgtctac tgctggcagt gatggccttt 360 gatcggtaca aggccattgg caacccgttg ctctacacag tcaacatgtc caacagagtg 420 tgctccctgc tcatggctgg agtttacttg ctgggaatgg cagatgctct gatacataca 480 acattaacat tccgcttatg cttttgtgga tcaaatgaga ttaatcattt cttctgtgat 540 ttacctccac tctacctcct ttcatgctca gatacagaga tcaatgagtt ggcattattc 600 atcttttttg gcttcattga actgagcacc atttctggag ttcttatctc ttattgttat 660 ataaccctat cagtcttgaa gatccgctct gctgagggga ggttcaaagc tttctccacc 720 tgcacctccc acttaactgc tgttgcaatt ttccagggaa ctatgctctt catgtatttt 780 cggccaagct cttcctactc ccttgatcaa gataaaatga cctcattgtt ttacaccctt 840 gtgattccca cattaaaccc actgatttat agcctacgga acaaggatgt gaaagaagcg 900 ctgaaaaaac tgaaaattaa aaagtggttt taa 933

<210> 802 <211> 310

Page 901

069269_0225_SL.TXT <212> PRT <213> Canis familiaris <400> 802

Met Asp Lys Gly Asn Cys Ser Ser Leu Thr Glu Phe Ile Phe Leu Gly 1 5 10 15 Ile Thr Asn Asn Pro Gly Met Lys Val Thr Leu Phe Ala Thr Phe Leu 20 25 30 Val Val Tyr Leu Ile Asn Leu Phe Ala Asn Leu Gly Met Ile Ile Leu 35 40 45 Ile Ile Ile Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Gln Leu Ser Phe Cys Asp Leu Cys Tyr Ser Thr Ala Val Gly Pro Lys 65 70 75 80 Met Leu Val Asp Leu Leu Ala Lys Asn Lys Ser Ile Pro Phe Phe Gly 85 90 95 Cys Ala Leu Gln Phe Leu Ile Phe Cys Met Phe Ala Asp Ser Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ala Phe Asp Arg Tyr Lys Ala Ile Gly Asn 115 120 125 Pro Leu Leu Tyr Thr Val Asn Met Ser Asn Arg Val Cys Ser Leu Leu 130 135 140 Met Ala Gly Val Tyr Leu Leu Gly Met Ala Asp Ala Leu Ile His Thr 145 150 155 160 Thr Leu Thr Phe Arg Leu Cys Phe Cys Gly Ser Asn Glu Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Pro Pro Leu Tyr Leu Leu Ser Cys Ser Asp Thr 180 185 190

Page 902

Glu Ile Asn 195 Glu Leu Ala Leu 069269_0225_SL.TXT Phe Ile Phe Phe Gly Phe 200 205 Ile Glu Leu Ser Thr Ile Ser Gly Val Leu Ile Ser Tyr Cys Tyr Ile Thr Leu Ser 210 215 220 Val Leu Lys Ile Arg Ser Ala Glu Gly Arg Phe Lys Ala Phe Ser Thr 225 230 235 240 Cys Thr Ser His Leu Thr Ala Val Ala Ile Phe Gln Gly Thr Met Leu 245 250 255 Phe Met Tyr Phe Arg Pro Ser Ser Ser Tyr Ser Leu Asp Gln Asp Lys 260 265 270 Met Thr Ser Leu Phe Tyr Thr Leu Val Ile Pro Thr Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys Leu 290 295 300 Lys Ile Lys Lys Trp Phe

305 310 <210> 803 <211> 936 <212> DNA <213> Canis familiaris <400> 803

atggatggaa aaaattgctc ttccgtgaat gaattccttc tcgtgggaat tagcaataag 60 cctggagtta aagtgactct atttatcaca tttctaattg tctatctcat cattcttgtt 120 gcaaacctcg ggatgatcat tttaattagg atggactccc agcttcacac acccatgtat 180 ttcttcctga gccatctctc cttcagtgac gtctgctatt ctacagcagt cggacccagg 240 atgctggtag gcttcattgc caagaacaag tcaattccct tctacagctg tgctatgcaa 300 tggttggtgt tctgtacctt tgtagattct gagtgtctac tgctggcagt gatggccttt 360 gatcggtaca aagccattag ccaccccttg ctctatacag tcagcatgtc cagcagaatg 420

Page 903

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tgctccctgc tgatggctgg ggtttacttg gtgggaatta tggatgcttc agtaaataca 480 atattaacat tccggttatg tttctgtgag tcgaatgtga ttaaccattt cttctgtgat 540 gtcccacctc tcctcttgtt atcttgctca gacacacaag ttaatgagtt agtgatattc 600 accatttttg gcttcattga actgattact ctttcagggc tttttgtgtc ttactgctat 660 attatcctag cggtgagaaa gatcaactct gctgagggga ggttcaaagc tttctccacc 720 tgcacctccc acttaactgc tgttgcaatt ttccagggaa ctctgctctt tatatatttc 780 cggccaagct cttcctactc ccttgatcaa gacaaaatta tttcattgtt ttactccctt 840 gtgattccca tgctaaaccc tctgatttat agcctacgga acaaggatgt gaaagaggcc 900 ctgaaaaaac ttaaaaataa aaagtggttt cattga 936

<210> 804 <211> 311 <212> PRT <213> Canis familiaris <400> 804

Met Asp Gly Lys Asn Cys Ser Ser Val Asn Glu Phe Leu Leu Val Gly 1 5 10 15 Ile Ser Asn Lys Pro Gly Val Lys Val Thr Leu Phe Ile Thr Phe Leu 20 25 30 Ile Val Tyr Leu Ile Ile Leu Val Ala Asn Leu Gly Met Ile Ile Leu 35 40 45 Ile Arg Met Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Ser Asp Val Cys Tyr Ser Thr Ala Val Gly Pro Arg 65 70 75 80 Met Leu Val Gly Phe Ile Ala Lys Asn Lys Ser Ile Pro Phe Tyr Ser 85 90 95 Cys Ala Met Gln Trp Leu Val Phe Cys Thr Phe Val Asp Ser Glu Cys 100 105 110

Page 904

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Leu Leu Leu 115 Ala Val Met Ala Phe Asp Arg Tyr Lys Ala Ile Ser His 120 125 Pro Leu Leu Tyr Thr Val Ser Met Ser Ser Arg Met Cys Ser Leu Leu 130 135 140 Met Ala Gly Val Tyr Leu Val Gly Ile Met Asp Ala Ser Val Asn Thr 145 150 155 160 Ile Leu Thr Phe Arg Leu Cys Phe Cys Glu Ser Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Val Pro Pro Leu Leu Leu Leu Ser Cys Ser Asp Thr 180 185 190 Gln Val Asn Glu Leu Val Ile Phe Thr Ile Phe Gly Phe Ile Glu Leu 195 200 205 Ile Thr Leu Ser Gly Leu Phe Val Ser Tyr Cys Tyr Ile Ile Leu Ala 210 215 220 Val Arg Lys Ile Asn Ser Ala Glu Gly Arg Phe Lys Ala Phe Ser Thr 225 230 235 240 Cys Thr Ser His Leu Thr Ala Val Ala Ile Phe Gln Gly Thr Leu Leu 245 250 255 Phe Ile Tyr Phe Arg Pro Ser Ser Ser Tyr Ser Leu Asp Gln Asp Lys 260 265 270 Ile Ile Ser Leu Phe Tyr Ser Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys Leu 290 295 300 Lys Asn Lys Lys Trp Phe His

305 310

Page 905

069269_0225_SL.TXT <210> 805 <211> 933 <212> DNA <213> Canis familiaris <400> 805

atggacaaag gaaattgctc ttccttgact gaattctttt tcttgggaat taccaataat 60 cctgagatga aagtgaccct attcaccatc actctggtta tttatctcat taatctcctg 120 gcaaatcttg gaatgattat tctaattaga atggattttc agctgaatac accaatgtac 180 tttttcctca gccatctctc tttctgtgac ctctgttatt ccacagcaat tgggcccaag 240 atgctggtgg atctatttgc caaaaacaaa tcaattccta tcataggctg tgctctgcaa 300 ttcttgatct tctgtacttt tgtagattct gagtgtctac tgctggcagt gatggcattt 360 gatcggtaca aggccattag caacccgtta ctctacacag tcaacatgtc caacagagtg 420 tgctccctgc tgatggctgg agtttacttg ctgggaacgg cagatgcttt gatacacaca 480 acattaacat tcagtttatg tttctgtgga tcaaatgaga ttaatcattt cttctgtgat 540 gtacctcctc tcctattgct ctcatgctca gatacacagg tgaatgagtt agtgatattc 600 accattttcg gcttcattga actgagtacc atcacaggag tccttgtctc ttattgttat 660 ataatcttat cagtcttaaa gatccgctct gctgaaggga ggttcagagc tttctccacc 720 tgcacctccc acttaactgc tgttgcaatt ttccagggaa ctatgctctt tatgtatttc 780 cggccaagct cttcctactc ccttgatcaa gacaaaatta cttcattgtt ttacaccctt 840 gtgattccca tgttaaaccc actgatttat agcctacgga acaaagatgt gaaaggggcc 900 ctagaaaaat tgaaaaataa aatatgtctt taa 933

<210> 806 <211> 310 <212> PRT <213> Canis familiaris <400> 806

Met Asp Lys Gly Asn Cys Ser Ser Leu Thr Glu Phe Phe Phe Leu Gly

1 5 10 15

Ile Thr Asn Asn Pro Glu Met Lys Val Thr Leu Phe Thr Ile Thr Leu

20 25 30

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Val Ile Tyr 35 Leu Ile Asn Leu Leu Ala Asn Leu Gly Met Ile Ile Leu 40 45 Ile Arg Met Asp Phe Gln Leu Asn Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Cys Asp Leu Cys Tyr Ser Thr Ala Ile Gly Pro Lys 65 70 75 80 Met Leu Val Asp Leu Phe Ala Lys Asn Lys Ser Ile Pro Ile Ile Gly 85 90 95 Cys Ala Leu Gln Phe Leu Ile Phe Cys Thr Phe Val Asp Ser Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ala Phe Asp Arg Tyr Lys Ala Ile Ser Asn 115 120 125 Pro Leu Leu Tyr Thr Val Asn Met Ser Asn Arg Val Cys Ser Leu Leu 130 135 140 Met Ala Gly Val Tyr Leu Leu Gly Thr Ala Asp Ala Leu Ile His Thr 145 150 155 160 Thr Leu Thr Phe Ser Leu Cys Phe Cys Gly Ser Asn Glu Ile Asn His 165 170 175 Phe Phe Cys Asp Val Pro Pro Leu Leu Leu Leu Ser Cys Ser Asp Thr 180 185 190 Gln Val Asn Glu Leu Val Ile Phe Thr Ile Phe Gly Phe Ile Glu Leu 195 200 205 Ser Thr Ile Thr Gly Val Leu Val Ser Tyr Cys Tyr Ile Ile Leu Ser 210 215 220 Val Leu Lys Ile Arg Ser Ala Glu Gly Arg Phe Arg Ala Phe Ser Thr 225 230 235 240

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Cys Thr Ser His Leu Thr Ala Val Ala Ile Phe Gln Gly Thr Met Leu 245 250 255 Phe Met Tyr Phe Arg Pro Ser Ser Ser Tyr Ser Leu Asp Gln Asp Lys 260 265 270 Ile Thr Ser Leu Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Glu Lys Leu 290 295 300 Lys Asn Lys Ile Cys Leu

305 310 <210> 807 <211> 975 <212> DNA <213> Canis familiaris <400> 807 atggatggaa aaaattgctc ttccgtgaat gaattccttc tcgtgggaat tagcaataag cctggagtta aagtgactct gtttatcaca tttctaatta tctatctcat cattcttgtt gcaaacctcg ggatgatcat tttaatcagg atggactccc agcttcacac acccatgtat ttcttcctga gccatctctc cttcagtgac gtctgctatt ctacagcagt cggacccagg atgctggtag gcttcattgc caagaacaag tcaatttcct tctacagctg tgctctgcaa ttcttgatct tctgtatttt tgcagattct gagtgtctac tgctggcagt gatggccttt gatcggtaca aagccattag ccaccccttg ctctatacag tcagcatgtc cagcagagtg tgctccctgc tgatggctgg ggtttacatg gtgggaatta tggatgcttc agtaaataca atattaacat tccggttatg tttctgtgag tcgaatgtga ttaaccattt cttctgtgat gtcccacctc tcctcttgtt atcttgctca gacacacaag ttaatgagtt agtgatattc accatttttg gcttcattga actgattact ctttcagggc tttttgtgtc ttactgctat attatcctag cggtgagaaa gatcaactct gctgagggga ggttcaaagc tttctccacc

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tgcacctccc acttaactgc tgttgcaatt ttccagggaa ctctgctctt tatgtatttc 780 cggccaagct cttcctactc ccttgatcaa gacaaaatta cttcattgtt ttactccctt 840 gtgattccca tgctaaaccc tctgatttat agcctacgga acaaggatgt gaaagaggcc 900 ctgaagaaac ttaaaaaaaa cttaaactta aaaaataaac taaaaaaaaa actaaaaaaa 960 attttaaaaa cttaa 975

<210> 808 <211> 324 <212> PRT <213> Canis familiaris <400> 808

Met Asp Gly 1 Lys Asn Cys Ser Ser 5 Val Asn Glu Phe Leu Leu Val Gly 10 15 Ile Ser Asn Lys Pro Gly Val Lys Val Thr Leu Phe Ile Thr Phe Leu 20 25 30 Ile Ile Tyr Leu Ile Ile Leu Val Ala Asn Leu Gly Met Ile Ile Leu 35 40 45 Ile Arg Met Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Ser Asp Val Cys Tyr Ser Thr Ala Val Gly Pro Arg 65 70 75 80 Met Leu Val Gly Phe Ile Ala Lys Asn Lys Ser Ile Ser Phe Tyr Ser 85 90 95 Cys Ala Leu Gln Phe Leu Ile Phe Cys Ile Phe Ala Asp Ser Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ala Phe Asp Arg Tyr Lys Ala Ile Ser His 115 120 125 Pro Leu Leu Tyr Thr Val Ser Met Ser Ser Arg Val Cys Ser Leu Leu 130 135 140

Page 909

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Met Ala Gly Val Tyr Met Val Gly Ile Met Asp Ala Ser Val Asn Thr 145 150 155 160 Ile Leu Thr Phe Arg Leu Cys Phe Cys Glu Ser Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Val Pro Pro Leu Leu Leu Leu Ser Cys Ser Asp Thr 180 185 190 Gln Val Asn Glu Leu Val Ile Phe Thr Ile Phe Gly Phe Ile Glu Leu 195 200 205 Ile Thr Leu Ser Gly Leu Phe Val Ser Tyr Cys Tyr Ile Ile Leu Ala 210 215 220 Val Arg Lys Ile Asn Ser Ala Glu Gly Arg Phe Lys Ala Phe Ser Thr 225 230 235 240 Cys Thr Ser His Leu Thr Ala Val Ala Ile Phe Gln Gly Thr Leu Leu 245 250 255 Phe Met Tyr Phe Arg Pro Ser Ser Ser Tyr Ser Leu Asp Gln Asp Lys 260 265 270 Ile Thr Ser Leu Phe Tyr Ser Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys Leu 290 295 300 Lys Lys Asn Leu Asn Leu Lys Asn Lys Leu Lys Lys Lys Leu Lys Lys 305 310 315 320

Ile Leu Lys Thr <210> 809 <211> 942 <212> DNA

Page 910

069269_0225_SL.TXT <213> Canis familiaris <400> 809 atggcctttg aaaactatac ccgcaattgc aggttttcct ggaaacttgg gtatgattat ttttttctca gccacttgtc atgctcaccg acttctttgt cagtggtttt ttgggttctt gaccgctatg tggccatctg tgtgtccagc tggtggttgg acgaatgcat ttcgtcttcc atgtcccccc tgctttccct gttgtggctg gagctgtggg atcctcattg ccatcatgaa tgctcttctc acctgaccgc cggcctagtg ccagtttctc gtgatcccca tgttgaaccc atccatagga ctattactag <210> 810 <211> 313 <212> PRT <213> Canis familiaris <400> 810 gagggtcacc gaattcattt cttcctgctc ttcctgagtt tctgattcgg gttgattccc ctttgtggat atctgcttct gaagaggaag gccatctctt tgtggcagca gagtgttttc caacccatta ttgtattcag tccctacatc atcgggtttg tttttgtggc cccaatgttc tgtatgtgct gacagcaggc agtcttcagt ggtttgacta gatccactct gccgatggga tgtctccatc ctatacggta actggatctc aacaaagtgg gcttatctac agcttgagga gaggaagttt tgtagggcat tcacaggttt gaattgcagc tttacttcat caatctaact gccttcacac gcccatgtac cctctgttgt gagcccaaag tcttgggctg tgctttgcaa tcctggcgtc catggcctat ttgccatgtc ccagagactc tgaacaccat gacccataca ttaatcattt cttctgtgat ttactaagtt ggtagttttt tcgtggtctc ctacatttat ggcgcaaagc cttttctaca ctcttttctt tatttatgta tgtcggtatt ttacacagca acaaggaggt caaagatgcc aa

120

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780

840

900

942

Met 1 Ala Phe Glu Asn 5 Tyr Leu Asn Cys Ser 20 Pro Gln Ser Phe Tyr 35 Phe Ile Asn

Thr Arg Val Thr 10 Glu Leu Gln Val 25 Phe Leu Leu Thr Gly Asn Leu

Phe Ile Phe Thr 15 Gly Phe Leu Leu 30 Phe Leu Gly Met Ile Ile Leu

Page 911

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Ile Arg 50 Val Asp Ser Arg Leu His 55 Thr Pro Met Tyr Phe Phe Leu 60 Ser His Leu Ser Phe Val Asp Ile Cys Phe Ser Ser Val Val Ser Pro Lys 65 70 75 80 Met Leu Thr Asp Phe Phe Val Lys Arg Lys Ala Ile Ser Phe Leu Gly 85 90 95 Cys Ala Leu Gln Gln Trp Phe Phe Gly Phe Phe Val Ala Ala Glu Cys 100 105 110 Phe Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ser Val Ala Met Ser Gln Arg Leu Cys Val Gln Leu 130 135 140 Val Val Gly Pro Tyr Ile Ile Gly Phe Val Asn Thr Met Thr His Thr 145 150 155 160 Thr Asn Ala Phe Arg Leu Pro Phe Cys Gly Pro Asn Val Leu Asn His 165 170 175 Phe Phe Cys Asp Met Ser Pro Leu Leu Ser Leu Val Cys Ala Asp Ser 180 185 190 Arg Leu Thr Lys Leu Val Val Phe Val Val Ala Gly Ala Val Gly Val 195 200 205 Phe Ser Gly Leu Thr Ile Val Val Ser Tyr Ile Tyr Ile Leu Ile Ala 210 215 220 Ile Met Lys Ile His Ser Ala Asp Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ser Ile Leu Tyr Gly Thr Leu Phe 245 250 255

Page 912

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Phe Ile Tyr Val Arg Pro Ser Ala Ser Phe Ser Leu Asp Leu Asn Lys 260 265 270 Val Val Ser Val Phe Tyr Thr Ala Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Ile His Arg Thr 290 295 300 Ile Thr Arg Arg Lys Phe Cys Arg Ala

305 310 <210> 811 <211> 657 <212> DNA <213> Canis familiaris <400> 811

acacaccaat acttttttct cagccacctc tcctgtgacc tttgctactg cacatcaatt 60 ggacccaaga tgttgctgga tccatttgcc aacatcaaaa caatttccat cactggcttc 120 catcactctt gagcttctgc acctgcagaa tgaatgtcta ttgctattgg tgacaatctc 180 tgattgatac aaagctattg gcaacccctg tgcttcctgc tcatggccag gatttcatga 240 gggatgtcaa atgctttgat actcctgaca ttaacattcc actgtctgtc tgtaggtcat 300 gtgatatatc atttcttctg tgatatctct ctctctcaac gattttatta tttttaacat 360 ttttgtcttc actgaactga gtaccatttt agcttgactc ttactatcct attcatcttg 420 aagaaccact cttctgaaag gaagttcaaa gttttctcca ccttcacctc ccacttagga 480 gctgttgcaa tcttctgggg aactatgctt ttcagatatt ctgggccaaa ttcttttttt 540 ctccttagat taagacaaaa tgaactcttt gttctacact catgtaattc ctatgttaaa 600 ttctctgatt tacagcctat ggaaaagaat gtgaaagaaa tggtggaaaa atttgaa 657

<210> 812 <211> 61 <212> PRT <213> Canis familiaris

Page 913

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<400> 812 Phe Ser Ala Thr Ser Pro Val Thr Phe Ala Thr His 1 Thr Asn Thr Phe 5 10 15 Ala His Gln Leu Asp Pro Arg Cys Cys Trp Ile His Leu Pro Thr Ser 20 25 30 Lys Gln Phe Pro Ser Leu Ala Ser Ile Thr Leu Glu Leu Leu His Leu 35 40 45 Gln Asn Glu Cys Leu Leu Leu Leu Val Thr Ile Ser Asp 50 55 60

<210> 813 <211> 939 <212> DNA <213> Canis familiaris <400> 813

atggctgttg agaactgcac tgtgattact gatttcatac tcctaggact ttctggcaga 60 aaagatgtgc agcaggggct ctttgtgctc tttctgctag tttacagcac aaccatgatt 120 gccaatctag ggatgatcct gctgatcaag ctggactcca ggctccacac gcccatgtat 180 tatttcctga gcaacctgtc tctctgtgac gtctgctact cctccactgt ctctcccaag 240 atgctggctg acttcttgtc tgagcaaaag agaattccat atgatttatg tgcaattcag 300 atgtattttt ttggggtctt tgcagatgtg gagtgtctca tgttggctgt catggcttat 360 gaccggtatg tagccatttg taatccactt ctttatacaa tcgccatgtc caggcaaatc 420 tgcatccagc ttgtgtccct tgcctacatc gtcggttttg tggattcagc aatccacacc 480 tgctgcacat ttcgattgtc gttctgcgat tccaatatca tcaatcactt tttctgtgac 540 atcccaccct tgctagccct ttcctcttca gatacatcca tcaatgagat agtgatgttc 600 actttcattg gttgtgtagt gggctgcagc atcatcactg ttctcctctc ctacagctat 660 atcctaacta ccatccttag aatgaactca gctgaaggga gacgcaaagc cttctctaca 720 tgtgcctccc acttgaccgc agtggctata tttcacggca cacttctgtt catgtatttc 780 cgaccgagct ccagttactc aatggacaca gacaaaatgt cttctgtctt ctacactgtg 840 gtcatcccta tgttaaaccc actcatctac agcttaagga ataaggatgt gaaaggtgcc 900

Page 914

069269_0225_SL.TXT ctgaaaaaag caatcagcac taaattatgt tctgggtga

939 <210> 814 <211> 312 <212> PRT <213> Canis familiaris <400> 814

Met 1 Ala Val Glu Asn 5 Cys Thr Val Ile Thr Asp Phe Ile Leu Leu Gly 10 15 Leu Ser Gly Arg Lys Asp Val Gln Gln Gly Leu Phe Val Leu Phe Leu 20 25 30 Leu Val Tyr Ser Thr Thr Met Ile Ala Asn Leu Gly Met Ile Leu Leu 35 40 45 Ile Lys Leu Asp Ser Arg Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Asn Leu Ser Leu Cys Asp Val Cys Tyr Ser Ser Thr Val Ser Pro Lys 65 70 75 80 Met Leu Ala Asp Phe Leu Ser Glu Gln Lys Arg Ile Pro Tyr Asp Leu 85 90 95 Cys Ala Ile Gln Met Tyr Phe Phe Gly Val Phe Ala Asp Val Glu Cys 100 105 110 Leu Met Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Thr Ile Ala Met Ser Arg Gln Ile Cys Ile Gln Leu 130 135 140 Val Ser Leu Ala Tyr Ile Val Gly Phe Val Asp Ser Ala Ile His Thr 145 150 155 160 Cys Cys Thr Phe Arg Leu Ser Phe Cys Asp Ser Asn Ile Ile Asn His 165 170 175

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Phe Phe Cys Asp 180 Ile Pro Ser Ile Asn 195 Glu Ile Val Cys Ser 210 Ile Ile Thr Val Ile 225 Leu Arg Met Asn Ser 230 Cys Ala Ser His Leu 245 Thr Phe Met Tyr Phe 260 Arg Pro Met Ser Ser 275 Val Phe Tyr Ile Tyr 290 Ser Leu Arg Asn Ile 305 Ser Thr Lys Leu Cys 310

Pro Leu Leu 185 Ala Leu Met Phe 200 Thr Phe Ile Leu 215 Leu Ser Tyr Ser Ala Glu Gly Arg Arg 235 Ala Val Ala Ile 250 Phe Ser Ser Ser 265 Tyr Ser Thr Val 280 Val Ile Pro Lys 295 Asp Val Lys Gly Ser Gly

Ser Ser Ser 190 Asp Thr Gly Cys 205 Val Val Gly Tyr 220 Ile Leu Thr Thr Lys Ala Phe Ser Thr 240 His Gly Thr Leu 255 Leu Met Asp Thr 270 Asp Lys Met Leu 285 Asn Pro Leu Ala 300 Leu Lys Lys Ala

<210> 815 <211> 933 <212> DNA <213> Canis familiaris <400> 815 atggagttgg agaaccacac ccagaacttt ggagggtgct gggaaccttg ggatgatctt tttttcctct gtatattgtc tgtgaagtct gagttctttc ttttgttatg tttcttttta attaatcaca actagttccc ctttgtagat gtatgttact tcttgggatt tagtgaccat tctactctgt taccctcatg atttgcacac cccgatgtac cttctgttat tgcccccaaa

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ttacttgtgg acttgatttc caaagaaaag accatttctt acaagggctg tgctgcacag 300 ttatattttt tctgctcttt ggttgacaca gaatctttcc tcttggctgc tatggcttat 360 gaccggtaca tagcaatctg caaccctctg ctttatatgg ttattatgtc caagagggtt 420 tgctcccagt ttgccattgg agcatttttg ggaggtacca tgagttcaat tattcacact 480 actaatacct tccatctgtc tttctgctcc aaagaaatta atcatttctt ctgtgatatc 540 tccccactct tctctctgtc ctgcactgat acttacatgc atgacatcat tctggtagtc 600 tttgctggtt tggtggaagc tatctgtctt ctagcagtcc ttctgtctta tgtctgcatc 660 atagcagcta ttcttaaaac agggtctgct gaaggaagaa agaaagggtt ttccacttgt 720 gcctcccatc tgaccgtagt cacgatctac catggtaccc tcatttttat ttatttgcgc 780 cccagcactg gtcattcgct ggatattgac aaagtgacct ctgtgttcta tacattgatc 840 atacctatgt tgaacccctt aatttacagt ctaaggaaca aagacgtcaa aaatgccttt 900 aggaaagtaa taggcagaaa attgctttct taa 933

<210> 816 <211> 310 <212> PRT <213> Canis familiaris <400> 816

Met Glu Leu Glu Asn His Thr Val Lys Ser Glu Phe Phe Leu Leu Gly 1 5 10 15 Phe Ser Asp His Pro Glu Leu Trp Arg Val Leu Phe Val Met Phe Leu 20 25 30 Phe Ile Tyr Ser Val Thr Leu Met Gly Asn Leu Gly Met Ile Leu Leu 35 40 45 Ile Thr Thr Ser Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60 Ile Leu Ser Phe Val Asp Val Cys Tyr Ser Ser Val Ile Ala Pro Lys 65 70 75 80 Leu Leu Val Asp Leu Ile Ser Lys Glu Lys Thr Ile Ser Tyr Lys Gly

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85 90 95

Cys Ala Ala Gln Leu Tyr Phe Phe Cys Ser Leu Val Asp Thr Glu Ser 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Val Ile Met Ser Lys Arg Val Cys Ser Gln Phe 130 135 140 Ala Ile Gly Ala Phe Leu Gly Gly Thr Met Ser Ser Ile Ile His Thr 145 150 155 160 Thr Asn Thr Phe His Leu Ser Phe Cys Ser Lys Glu Ile Asn His Phe 165 170 175 Phe Cys Asp Ile Ser Pro Leu Phe Ser Leu Ser Cys Thr Asp Thr Tyr 180 185 190 Met His Asp Ile Ile Leu Val Val Phe Ala Gly Leu Val Glu Ala Ile 195 200 205 Cys Leu Leu Ala Val Leu Leu Ser Tyr Val Cys Ile Ile Ala Ala Ile 210 215 220 Leu Lys Thr Gly Ser Ala Glu Gly Arg Lys Lys Gly Phe Ser Thr Cys 225 230 235 240 Ala Ser His Leu Thr Val Val Thr Ile Tyr His Gly Thr Leu Ile Phe 245 250 255 Ile Tyr Leu Arg Pro Ser Thr Gly His Ser Leu Asp Ile Asp Lys Val 260 265 270 Thr Ser Val Phe Tyr Thr Leu Ile Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Phe Arg Lys Val Ile

Page 918

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290 295 300

Gly Arg Lys Leu Leu Ser

305 310 <210> 817 <211> 960 <212> DNA <213> Canis familiaris <400> 817

atggcagaaa cgggggaaga gaactgcacc agtgtgacag aattcattct gcttggatta 60 gcagatgccc cagagctgag agtcttcctc ttcctgctgt ttcttctcat ctatggagtc 120 acggttttgg gaaatctggg catgatcgca gtgatccagg tcagctctca gcttcacact 180 cccatgtact ttttcctcag ccacttgtcc tttgtggatt tttgctactc cacgatcatc 240 gtgccaaaga tgctgcccaa tatcttaaac agggacaaag ccatctcctt cctcggttgc 300 atggtgcagt tctatttatt ttgtacttat gcaatcactg aggtcttcct gttggctgtg 360 atggcctatg accgcttcgt ggccatctgc aacccactgc tgtacatggt caccatgtcc 420 cagaatctct gtatggagct ggtgtcctgc tgctacctct gtgggacggc ctgttctctg 480 atccacttgt gtttagccct tcagatccca tcctatagat cagatgtgat taaccacttc 540 ttttgtgatc taccccctct cttatctctt gcttgctctg atgtcactat gaatgaactc 600 atggtgtcca ttgtggccac cttcaacgag atcatcacca tcatgatcat cctcacctcc 660 tatttgctga ttctcatcac tatcctgagg atgcgctctg cagagggaag gcgcaaagcc 720 ttttccacct gtgcttctca cttcacagcc atccttgtct tccatggaac aatccttttc 780 aattattgtc ggcccagttc tggcaacagt atggatactg acaaggtggc cacggtgttc 840 tacaccatag tgattcccat gctgaaccct ctcatctata gtctgaggaa caaggatgtg 900 aaagaagctc tcaagaaagt attgcgatct agagtaccct ttgaaaaact attttcttga 960

<210> 818 <211> 319 <212> PRT <213> Canis familiaris <400> 818

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Met 1 Ala Glu Thr Gly 5 Glu Glu Asn Cys Thr Ser Val Thr Glu Phe Ile 10 15 Leu Leu Gly Leu Ala Asp Ala Pro Glu Leu Arg Val Phe Leu Phe Leu 20 25 30 Leu Phe Leu Leu Ile Tyr Gly Val Thr Val Leu Gly Asn Leu Gly Met 35 40 45 Ile Ala Val Ile Gln Val Ser Ser Gln Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Ser His Leu Ser Phe Val Asp Phe Cys Tyr Ser Thr Ile Ile 65 70 75 80 Val Pro Lys Met Leu Pro Asn Ile Leu Asn Arg Asp Lys Ala Ile Ser 85 90 95 Phe Leu Gly Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Tyr Ala Ile 100 105 110 Thr Glu Val Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Met Val Thr Met Ser Gln Asn Leu Cys 130 135 140 Met Glu Leu Val Ser Cys Cys Tyr Leu Cys Gly Thr Ala Cys Ser Leu 145 150 155 160 Ile His Leu Cys Leu Ala Leu Gln Ile Pro Ser Tyr Arg Ser Asp Val 165 170 175 Ile Asn His Phe Phe Cys Asp Leu Pro Pro Leu Leu Ser Leu Ala Cys 180 185 190 Ser Asp Val Thr Met Asn Glu Leu Met Val Ser Ile Val Ala Thr Phe 195 200 205

Page 920

Asn Glu 210 Ile Ile Thr Ile Met 215 069269_0225_SL.TXT Ile Ile Leu Thr Ser Tyr 220 Leu Leu Ile Leu Ile Thr Ile Leu Arg Met Arg Ser Ala Glu Gly Arg Arg Lys Ala 225 230 235 240 Phe Ser Thr Cys Ala Ser His Phe Thr Ala Ile Leu Val Phe His Gly 245 250 255 Thr Ile Leu Phe Asn Tyr Cys Arg Pro Ser Ser Gly Asn Ser Met Asp 260 265 270 Thr Asp Lys Val Ala Thr Val Phe Tyr Thr Ile Val Ile Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu 290 295 300 Lys Lys Val Leu Arg Ser Arg Val Pro Phe Glu Lys Leu Phe Ser 305 310 315

<210> 819 <211> 936 <212> DNA <213> Canis familiaris <400> 819

atgggggaag agaactgcac cagtgtaaca gagttcattc tgcttggatt agcagatgcc 60 ccagagctga gagtcttcct cttcctgctg tttcttctca tctatggagt cacggttttg 120 ggaaatctgg gcatgatcgc agtgatccag gtcagctctc agcttcacac tcccatgtac 180 tttttcctca gccacttgtc ctttgtggat ttttgctact ccacgatcat cgtgccaaag 240 atgctgccca atatcttaaa cagggacaaa gccatctcct tcctcggttg catggtgcag 300 ttctatttat tttgtactta tgcaatcact gaggtcttcc tgttggctgt gatggcctat 360 gaccgcttcg tggccatctg caacccactg ctgtacatgg tcaccatgtc ccggaatctc 420 tgtatggagc tggtgtcctg ctgctacctc tgtgggacag cctgttctct gatccacttg 480 tgtttagccc ttcagatccc atcctataga tcaaatgtga ttaaccactt cttttgtgat 540

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ctaccccctc tcttatctct tgcttgctct gatgtcacta tgaatgaact gttgctgtac 600 atcgtggcca ccttcaacga gctcaccacc atcctgatca tccttacctc ctatttgctg 660 attctcatca ccatcctgag gatgcgctct gcagagggaa ggcgcaaagc cttttccacc 720 tgtgcctccc acctcacagc catccttgtc ttccatggaa caatcctttt catttattgt 780 cggccgggtt cgggcaacag tatggatgct gacaaggtgg ccacagtgtt ctacaccata 840 gtgattccca tgctgaaccc cctcatctat agtctgagga ataaggatgt gaaagaagct 900 ctcagaaaag tggtgagctc caaaatgttt tcctag 936

<210> 820 <211> 311 <212> PRT <213> Canis familiaris <400> 820

Met Gly Glu Glu Asn Cys Thr Ser Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ala Asp Ala Pro Glu Leu Arg Val Phe Leu Phe Leu Leu Phe Leu 20 25 30 Leu Ile Tyr Gly Val Thr Val Leu Gly Asn Leu Gly Met Ile Ala Val 35 40 45 Ile Gln Val Ser Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Phe Cys Tyr Ser Thr Ile Ile Val Pro Lys 65 70 75 80 Met Leu Pro Asn Ile Leu Asn Arg Asp Lys Ala Ile Ser Phe Leu Gly 85 90 95 Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Tyr Ala Ile Thr Glu Val 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn 115 120 125

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Pro Leu 130 Leu Tyr Met Val Thr Met Ser Arg Asn Leu Cys Met Glu Leu 135 140 Val Ser Cys Cys Tyr Leu Cys Gly Thr Ala Cys Ser Leu Ile His Leu 145 150 155 160 Cys Leu Ala Leu Gln Ile Pro Ser Tyr Arg Ser Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Pro Pro Leu Leu Ser Leu Ala Cys Ser Asp Val 180 185 190 Thr Met Asn Glu Leu Leu Leu Tyr Ile Val Ala Thr Phe Asn Glu Leu 195 200 205 Thr Thr Ile Leu Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Ile Thr 210 215 220 Ile Leu Arg Met Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Ile Leu Val Phe His Gly Thr Ile Leu 245 250 255 Phe Ile Tyr Cys Arg Pro Gly Ser Gly Asn Ser Met Asp Ala Asp Lys 260 265 270 Val Ala Thr Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys Val 290 295 300 Val Ser Ser Lys Met Phe Ser

305 310 <210> 821 <211> 936 <212> DNA

Page 923

069269_0225_SL.TXT <213> Canis familiaris <400> 821 atgggtgagg agaactgcac cagtgtgaca gagttcattc tgcttggatt agcagatgcc 60 ccagagctga gagtcttcct cttcctgctg tttcttctca tctatggagt cacggttttg 120 ggaaatctgg gcatgatcgc agtgattcag gtcagctctc agcttcacac tcccatgtac 180 tttttcctca gccacttgtc ctttgtggat ttttgctact ccacgatcat cgtgccaaag 240 atgctgccca atatcttaaa cagggacaaa gccatctcct tcctcggttg catggtgcag 300 ttctatttat tttgtacatg tgtggtaact gaggtcttcc tgttggctgt gatggcctat 360 gaccgcttcg tggccatctg caacccactg ctgtacatgg tcaccatgtc ccagaatctc 420 tgtatggagc tggtgtcctg ctgctacctc tgtgggacgg cctgttctct gatccacttg 480 tgtttagccc ttcagatccc atcctataga tcagatgtga ttaaccactt cttttgtgat 540 ctaccccctc tcttatctct tgcttgctct gatgtcacta tgaatgaatt gttgctgtac 600 atcgtggcca ccttcaacga gctcaccacc atcctgatca tccttacctc ctatttgctg 660 attctcatca ccatcctgag gatgcgctct gcagagggaa ggcgcaaagc cttttccacc 720 tgtgcctccc acctcacagc catccttgtc ttccatggaa caatcctttt catttattgt 780 cggccaggtt cgggcaacag tatggatgct gacaaggtgg ccacagtgtt ctacaccata 840 gtgattccca tgctgaaccc cctcatctat agtctgagga ataaggatgt gaaagaagct 900 ctcaggaaag tggtgagctc caaaatgttt tcctag 936 <210> 822 <211> 311 <212> PRT <213> Canis familiaris <400> 822

Met Gly Glu Glu Asn Cys Thr Ser 1 5 Leu Ala Asp Ala Pro Glu Leu Arg 20 Leu Ile Tyr Gly Val Thr Val Leu 35 40

Val Thr Glu Phe Ile Leu Leu Gly 10 15 Val Phe Leu Phe Leu Leu Phe Leu 25 30 Gly Asn Leu Gly Met Ile Ala Val 45

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Ile Gln 50 Val Ser Ser Gln Leu His 55 Thr Pro Met Tyr Phe Phe Leu 60 Ser His Leu Ser Phe Val Asp Phe Cys Tyr Ser Thr Ile Ile Val Pro Lys 65 70 75 80 Met Leu Pro Asn Ile Leu Asn Arg Asp Lys Ala Ile Ser Phe Leu Gly 85 90 95 Cys Met Val Gln Phe Tyr Leu Phe Cys Thr Cys Val Val Thr Glu Val 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Val Thr Met Ser Gln Asn Leu Cys Met Glu Leu 130 135 140 Val Ser Cys Cys Tyr Leu Cys Gly Thr Ala Cys Ser Leu Ile His Leu 145 150 155 160 Cys Leu Ala Leu Gln Ile Pro Ser Tyr Arg Ser Asp Val Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Pro Pro Leu Leu Ser Leu Ala Cys Ser Asp Val 180 185 190 Thr Met Asn Glu Leu Leu Leu Tyr Ile Val Ala Thr Phe Asn Glu Leu 195 200 205 Thr Thr Ile Leu Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Ile Thr 210 215 220 Ile Leu Arg Met Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Ile Leu Val Phe His Gly Thr Ile Leu 245 250 255

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Phe Ile Tyr Cys 260 Arg Pro Gly Ser Gly Asn Ser Met Asp Ala Asp Lys 265 270 Val Ala Thr Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys Val 290 295 300 Val Ser Ser Lys Met Phe Ser

305 310 <210> 823 <211> 942 <212> DNA <213> Canis <400> 823 atgttactgt tacccagaac gtaggtaatc tacttcttcc aaggccctgg cagttctttt tatgaccgct ctctgtgcca acatgctctg gagttctctg ttcatttttg tttatcgttg acctgcgcct tgtgtgccca familiaris cagagagaaa tgcaaatccc ttgggatgat tcagccacct caaacctggt tcttttgtac ttgtggccat tgctggtggt tggtcaaatt cattgatctc ccacctttaa tcaccatcct cccatctgac actccaaaaa taaaagtggg tctcttcttg agttataatc ctcagtggtg tgcagaagac ctttgtggta ttgcaatcct cggatcatat atcttttcag cctgtcttgc tgaggtcagc caagatgcgt tgccatcacc ctcaaggcac gctacattca atttttctgg aagattaacc gatttctgct agaaccattt gctgaatcct ctgctctaca gcatggggag ggtttcaaca tctgatactt acactgctca tcagccagtg atcttccatg acagtcaaag ctctcttggg ccatctatag ccaagctgca actcctccat catttccagg ttttattagc cagtgacagc taacatgttc ccatcaatca acatcagtca tcattctctt gtcgccgcaa ggaccatcct tggcatctgt cttctcagat tgtcactgtt cacccccatg cattgctccc atgtgtagta tgtgatggcc gtcccagaag cttgatactc tttcttctgt gttgctgctt gtcttacgta agccttttcc ttttctctac gttttacaca

120

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Page 926

900

942

069269_0225_SL.TXT gtggtgatcc ccatgttgaa tcccctgatc tacagtctga gaaataagga tgtcaagggt acagtcaata aattaatagg tactaaagtt ttttcttttt ga <210> 824 <211> 313 <212> PRT <213> Canis familiaris <400> 824

Met 1 Leu Leu Ser Glu Arg Asn Lys Ser Gly Ala Thr Phe Thr Leu Leu 5 10 15 Gly Phe Ser Asp Tyr Pro Glu Leu Gln Ile Pro Leu Phe Leu Ile Phe 20 25 30 Leu Ala Ile Tyr Ser Val Thr Val Val Gly Asn Leu Gly Met Ile Val 35 40 45 Ile Ile Lys Ile Asn Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser His Leu Ser Val Val Asp Phe Cys Tyr Ser Ser Ile Ile Ala Pro 65 70 75 80 Lys Ala Leu Ala Asn Leu Val Ala Glu Asp Arg Thr Ile Ser Phe Pro 85 90 95 Gly Cys Val Val Gln Phe Phe Phe Phe Cys Thr Phe Val Val Ala Glu 100 105 110 Ser Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Thr Val Thr Ala Ser Gln Lys Leu Cys Ala Met 130 135 140 Leu Val Val Gly Ser Tyr Ala Trp Gly Val Thr Cys Ser Leu Ile Leu 145 150 155 160 Thr Cys Ser Val Val Lys Leu Ser Phe Gln Gly Phe Asn Thr Ile Asn

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165 170 175

His Phe Phe Cys 180 Glu Phe Ser Ala Leu Ile Ser Leu Ser Cys Ser Asp 185 190 Thr Tyr Ile Ser Gln Leu Leu Leu Phe Ile Phe Ala Thr Phe Asn Glu 195 200 205 Val Ser Thr Leu Leu Ile Ile Leu Leu Ser Tyr Val Phe Ile Val Val 210 215 220 Thr Ile Leu Lys Met Arg Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr Ile 245 250 255 Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg His Thr Val 260 265 270 Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Thr Val Asn Lys 290 295 300 Leu Ile Gly Thr Lys Val Phe Ser Phe 305 310

<210> 825 <211> 939 <212> DNA <213> Canis familiaris <400> 825 atggctgtaa gaaatctgag tgtggagatg acctttgccc tcttgggttt cgcggattac ccagagcttc agattcctct cttcctcttg tttctgatca tgtacattat caccgtggta ggaaatcttg ggatgatagt aatcatcaag attaacccca aatttcacac tcccatgtac tttttcctca gccacctttc ttttgttgat ttttgttact cttccattgt tactcccaag Page 928

120

180

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069269_0225_SL.TXT ctgcttgaga acctggtcat ggaggataaa tacttcttgt cctgcactgc tgtggtgacg gatcgctttg tggccatttg caaccctctg tgtgccctgc tggtgtctgg gtcgtatctc tgctatgctc tccagctaaa cttttctgga tacacagctc tcattgctgt ctccagctca ggctttgcca ctttcaatga ggtgagtaca atattcgtga ctgtactaaa tatccattct tgtgcctccc acctgactgc cattaccatc gtgcccaact ccaaaaactc caggcaaact gtcaacccta tgctgaaccc tctgatctac ctccggaaat taatagacac aaaagtccca <210> 826 <211> 312 <212> PRT <213> Canis familiaris aacatcttct actttagctg catgttgcag gaatccttcc tgctggcagt gatggcctat ctttattcag tggtcatgtc gcagaggctc tggggtatgt ttggtccctt ggtactcctc cataacacaa tcaaccattt tttctgtgaa gacatactca ttccccacct gctgcctttt ctgctgatca tcctcacttc atacactttt gccagtgggc atcgcaaagc cttctccacc ttccacggga ccatcctttc cctctactgt gtcaaagtgg cctctgtatt ttatacagtg agcctgagga ataaagatgt gaaagatgcc ttccactga

300

360

420

480

540

600

660

720

780

840

900

939 <400> 826

Met Ala Val Arg Asn Leu Ser Val 1 5 Phe Ala Asp Tyr Pro Glu Leu Gln 20 Ile Met Tyr Ile Ile Thr Val Val 35 40 Ile Lys Ile Asn Pro Lys Phe His 50 55 His Leu Ser Phe Val Asp Phe Cys 65 70

Glu Met 10 Thr Phe Ala Leu Leu 15 Gly Ile 25 Pro Leu Phe Leu Leu 30 Phe Leu Gly Asn Leu Gly Met 45 Ile Val Ile Thr Pro Met Tyr 60 Phe Phe Leu Ser Tyr Ser Ser 75 Ile Val Thr Pro Lys 80

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Leu Leu Glu Asn Leu 85 Val Met Glu Asp Lys Asn Ile Phe Tyr Phe Ser 90 95 Cys Met Leu Gln Tyr Phe Leu Ser Cys Thr Ala Val Val Thr Glu Ser 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ser Val Val Met Ser Gln Arg Leu Cys Ala Leu Leu 130 135 140 Val Ser Gly Ser Tyr Leu Trp Gly Met Phe Gly Pro Leu Val Leu Leu 145 150 155 160 Cys Tyr Ala Leu Gln Leu Asn Phe Ser Gly His Asn Thr Ile Asn His 165 170 175 Phe Phe Cys Glu Tyr Thr Ala Leu Ile Ala Val Ser Ser Ser Asp Ile 180 185 190 Leu Ile Pro His Leu Leu Pro Phe Gly Phe Ala Thr Phe Asn Glu Val 195 200 205 Ser Thr Leu Leu Ile Ile Leu Thr Ser Tyr Thr Phe Ile Phe Val Thr 210 215 220 Val Leu Asn Ile His Ser Ala Ser Gly His Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr Ile Leu 245 250 255 Ser Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg Gln Thr Val Lys 260 265 270 Val Ala Ser Val Phe Tyr Thr Val Val Asn Pro Met Leu Asn Pro Leu 275 280 285

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Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Leu Arg Lys Leu 290 295 300

Ile Asp Thr Lys Val Pro Phe His 305 310 <210> 827 <211> 945 <212> DNA <213> Canis familiaris <400> 827

atgttgttag cagaaggcaa tcagagtgtt ggagccacat tcaccctctt gggcttctcg 60 gaatatccag acttccaggt tcccttgcta ttggtgttct tgaccatcta cacagtcact 120 gtggtaggga acctgggcat gatcatgatc atcagggtca gtccccgact ccacaccccc 180 atgtactttt tcctcagcca cttgtccttt gtcgatttct gttattccac cacagttaca 240 cccaaactgt tggagaattt ggttgtggaa gacagatcca tctccttcgt aggctgcatc 300 atgcagttct tcttggcttg tgtatgtgcg gtggcagaaa cattcatgtt ggcagtgatg 360 gcctatgacc gatttgtggc tgtttgtaac cctctactct acacggttgt catgtcccag 420 aagctgtgtg cgttgttagt ggcggggccc tacatatggg gtatagcctc ttccctgaca 480 ctcacctgtt ttctcctgac attatccttc tgtgggtcta ataccataaa taattttgtc 540 tgtgagcact ctgtcattgt ctctgtctcc tgctctgacc cctacatcag ccaaatgctt 600 tgttttgtca ttgccatatt caacgaagtc agcagcctgg tcatcatttt cactacttat 660 attttcattt ttgtcacagt cataaaaatg tcttctgctg gtgggcgcca aaaagctttc 720 tccacttgtg cctcccacct gactgccatc accatcttcc atgggactat cctgttcctt 780 tattgtgtac ccaactccca aaactcatgg ctcatagtca aaataggttc tttattttat 840 acagtggtga ttcctatgct gaaccctctg atctatagcc tccgaaataa agacgtgaag 900 gagagtgtca agaagttaat aaatcactca atacaagttt gttga 945

<210> 828 <211> 314 <212> PRT <213> Canis familiaris

Page 931

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<400> 828 Met 1 Leu Leu Ala Glu Gly Asn Gln Ser Val Gly Ala Thr Phe Thr Leu 5 10 15 Leu Gly Phe Ser Glu Tyr Pro Asp Phe Gln Val Pro Leu Leu Leu Val 20 25 30 Phe Leu Thr Ile Tyr Thr Val Thr Val Val Gly Asn Leu Gly Met Ile 35 40 45 Met Ile Ile Arg Val Ser Pro Arg Leu His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ser His Leu Ser Phe Val Asp Phe Cys Tyr Ser Thr Thr Val Thr 65 70 75 80 Pro Lys Leu Leu Glu Asn Leu Val Val Glu Asp Arg Ser Ile Ser Phe 85 90 95 Val Gly Cys Ile Met Gln Phe Phe Leu Ala Cys Val Cys Ala Val Ala 100 105 110 Glu Thr Phe Met Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Val 115 120 125 Cys Asn Pro Leu Leu Tyr Thr Val Val Met Ser Gln Lys Leu Cys Ala 130 135 140 Leu Leu Val Ala Gly Pro Tyr Ile Trp Gly Ile Ala Ser Ser Leu Thr 145 150 155 160 Leu Thr Cys Phe Leu Leu Thr Leu Ser Phe Cys Gly Ser Asn Thr Ile 165 170 175 Asn Asn Phe Val Cys Glu His Ser Val Ile Val Ser Val Ser Cys Ser 180 185 190 Asp Pro Tyr Ile Ser Gln Met Leu Cys Phe Val Ile Ala Ile Phe Asn 195 200 205

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Glu Val Ser Ser Leu Val Ile Ile Phe Thr Thr Tyr Ile Phe Ile Phe 210 215 220 Val Thr Val Ile Lys Met Ser Ser Ala Gly Gly Arg Gln Lys Ala Phe 225 230 235 240 Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr 245 250 255 Ile Leu Phe Leu Tyr Cys Val Pro Asn Ser Gln Asn Ser Trp Leu Ile 260 265 270 Val Lys Ile Gly Ser Leu Phe Tyr Thr Val Val Ile Pro Met Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ser Val Lys 290 295 300 Lys Leu Ile Asn His Ser Ile Gln Val Cys

305 310 <210> 829 <211> 891 <212> DNA <213> Canis familiaris <400> 829

gttcctctct tcctggtttt cttgtctatc tatatggtca ctactgtggg aaatttgggc 60 atgataataa ttatcaagat caatcctaaa ttccacacgg tcatgtactt tttcctcagc 120 cacttgtcct ttgtagattt ctgttattcc actgtagtta cacctaaatt gttggagaac 180 ttgactgtgg aagacagaac catctccttt tctggttgta ttatgcaatt ttgctttgct 240 tgcttatttg gagtcacaga aacttttatg ttagcagcga tggcttttta tgttagcagc 300 gatggctatg accgttttgt agcagtttgt aaccccttgc tgtataccac tactatgtct 360 cagaagcttt gcactctgct ggtagctggg tcttactcat ggggtatagt ctgttccatg 420 acactcacat attttcttct tgcattatcc tattgtgagt ctagcatcat aaataatttc 480 atctgtgacc attctgtaat tgtttctgtc tcctgttcag acccttatat cagccagatg 540

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ctgtgtttta ttattgccgt attcaatgag gtgagcagcc tgatgattat tctgatgtct 600 tatatactca tttttatcac tgttatgaag atgccttctg caagtgggtg ccggaaaacc 660 ttttccacct gtgcctctca cctgacagcc atcaccatat tccatgggac catccttttc 720 ctttactgtg tccctaatcc taaaacttct tggctcaccg ttaaagtggc atctgtgttt 780 tacacagtgg tgattcccat gctgaatccc ttgatctaca gccttaggaa caaagctgtg 840 aaagacacat tcagaagact agtggtagca aaattgcttt gtcacttaat a 891

<210> 830 <211> 297 <212> PRT <213> Canis familiaris <400> 830

Val Pro Leu Phe Leu Val Phe Leu Ser Ile Tyr Met Val Thr Thr Val 1 5 10 15 Gly Asn Leu Gly Met Ile Ile Ile Ile Lys Ile Asn Pro Lys Phe His 20 25 30 Thr Val Met Tyr Phe Phe Leu Ser His Leu Ser Phe Val Asp Phe Cys 35 40 45 Tyr Ser Thr Val Val Thr Pro Lys Leu Leu Glu Asn Leu Thr Val Glu 50 55 60 Asp Arg Thr Ile Ser Phe Ser Gly Cys Ile Met Gln Phe Cys Phe Ala 65 70 75 80 Cys Leu Phe Gly Val Thr Glu Thr Phe Met Leu Ala Ala Met Ala Phe 85 90 95 Tyr Val Ser Ser Asp Gly Tyr Asp Arg Phe Val Ala Val Cys Asn Pro 100 105 110 Leu Leu Tyr Thr Thr Thr Met Ser Gln Lys Leu Cys Thr Leu Leu Val 115 120 125

Page 934

Ala Gly 130 Ser Tyr Ser Trp Gly 135 069269_0225_SL.TXT Ile Val Cys Ser Met Thr 140 Leu Thr Tyr Phe Leu Leu Ala Leu Ser Tyr Cys Glu Ser Ser Ile Ile Asn Asn Phe 145 150 155 160 Ile Cys Asp His Ser Val Ile Val Ser Val Ser Cys Ser Asp Pro Tyr 165 170 175 Ile Ser Gln Met Leu Cys Phe Ile Ile Ala Val Phe Asn Glu Val Ser 180 185 190 Ser Leu Met Ile Ile Leu Met Ser Tyr Ile Leu Ile Phe Ile Thr Val 195 200 205 Met Lys Met Pro Ser Ala Ser Gly Cys Arg Lys Thr Phe Ser Thr Cys 210 215 220 Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Thr Ile Leu Phe 225 230 235 240 Leu Tyr Cys Val Pro Asn Pro Lys Thr Ser Trp Leu Thr Val Lys Val 245 250 255 Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu Ile 260 265 270 Tyr Ser Leu Arg Asn Lys Ala Val Lys Asp Thr Phe Arg Arg Leu Val 275 280 285 Val Ala Lys Leu Leu Cys His Leu Ile

290 295 <210> 831 <211> 936 <212> DNA <213> Canis familiaris <400> 831 atggatgaga aaaatttcac cgaagtgaaa gaatttatac ttctagggtt cacagaggac

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ttgtggttac agaaagtact ctttgttatt ttcctcttca tctatgttac cagtctttca 120 gggaacatga ctctgatttc tctgatctgt gctgattctc ggctccacac agccatgtat 180 ttcttcattg ggaatctttc attccttgat ctctggtact cttctgttta tgctccccaa 240 attcttagga cttgtatggc tgaagacaaa agcatctcct ttgctggctg cctagctcag 300 ttcttcttct ctgctggtct ggcatacagt gagtgttacc tgttggctgc catggcttat 360 gaccgctatg tggccatctc caaccctttg ctttattccc agacaatgtc ctcaaggtta 420 tgtgccagtc tcgttgcagc ttcatacctt ggtggctttc ttaactcaac catcattacc 480 agcgagacat ttaccctgag cttctgtggg agcaatgtca ttgatgatta tttctgtgac 540 ctgccacccc ttgtaaagct ggcctgcgat gtgaaggaga gctaccaggc tgtgctctat 600 ttcatactgg cctccaatgt cattgctccc actgtgctga tcctggcctc ttacctcttc 660 atcattgctg ctatcttgaa gatccgctcc actcagggcc gcctcaaagc tgtctccacc 720 tgtggctctc atctgacagc tgtcaccttg tactatggct ctattctctt tatttactcc 780 cgaccaagta ccagctatgc cctggaaagg gataaagtgg tgtcagtgtt ctatactgtg 840 gtgataccat tgttgaatcc cttaatctat agcttaagaa ataaggatgt taaagaggct 900 ctgaagaaaa tgttagataa ggcaccattt tcttaa 936 <210> 832 <211> 311 <212> PRT <213> Canis familiaris <400> 832 Met Asp Glu Lys Asn Phe Thr Glu Val Lys Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Thr Glu Asp Leu Trp Leu Gln Lys Val Leu Phe Val Ile Phe Leu 20 25 30 Phe Ile Tyr Val Thr Ser Leu Ser Gly Asn Met Thr Leu Ile Ser Leu 35 40 45 Ile Cys Ala Asp Ser Arg Leu His Thr Ala Met Tyr Phe Phe Ile Gly 50 55 60

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Asn 65 Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val Tyr Ala Pro Gln 70 75 80 Ile Leu Arg Thr Cys Met Ala Glu Asp Lys Ser Ile Ser Phe Ala Gly 85 90 95 Cys Leu Ala Gln Phe Phe Phe Ser Ala Gly Leu Ala Tyr Ser Glu Cys 100 105 110 Tyr Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser Asn 115 120 125 Pro Leu Leu Tyr Ser Gln Thr Met Ser Ser Arg Leu Cys Ala Ser Leu 130 135 140 Val Ala Ala Ser Tyr Leu Gly Gly Phe Leu Asn Ser Thr Ile Ile Thr 145 150 155 160 Ser Glu Thr Phe Thr Leu Ser Phe Cys Gly Ser Asn Val Ile Asp Asp 165 170 175 Tyr Phe Cys Asp Leu Pro Pro Leu Val Lys Leu Ala Cys Asp Val Lys 180 185 190 Glu Ser Tyr Gln Ala Val Leu Tyr Phe Ile Leu Ala Ser Asn Val Ile 195 200 205 Ala Pro Thr Val Leu Ile Leu Ala Ser Tyr Leu Phe Ile Ile Ala Ala 210 215 220 Ile Leu Lys Ile Arg Ser Thr Gln Gly Arg Leu Lys Ala Val Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Ala Val Thr Leu Tyr Tyr Gly Ser Ile Leu 245 250 255 Phe Ile Tyr Ser Arg Pro Ser Thr Ser Tyr Ala Leu Glu Arg Asp Lys 260 265 270

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Val Val Ser 275 Val Phe Tyr Thr Val Val Ile Pro Leu Leu Asn Pro Leu 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys Met 290 295 300 Leu Asp Lys Ala Pro Phe Ser 305 310

<210> 833 <211> 951 <212> DNA <213> Canis familiaris <400> 833

atggaactag atgaaggaaa tcagagctct gtgaccacat tcattctcct gggtttctca 60 gaatacccac acctccagat gcccctcttc ctggtgttct tgactgtcta cacggtcact 120 ctggtgggga atctgggcat aatcatggtc gtaaggatca atcccaaact ccacaccccc 180 atgtactttt tcctcagcca cctatccttt ttggatattt gttattccag tgtctttaca 240 ccgaaactat tagaaacctt ggtcacagaa gacagaagta tctccttcaa aggatgcatg 300 gtgcaatttt tcttcatttg tgcatttgta attacggaaa tgttcatgtt ggcagtaatg 360 gcctatgacc gatttgtggc tgtctgtaac cctctgctct acacagttgc tatgtctcag 420 aaactctgtg ccctcttggt agctggaacc tacacgtggg gtggcatatg ttccttgaca 480 ctcacatact ctcttttgga actatcctac tgtggttcca atatcataaa tcactttggc 540 tgtgagtatt ctgccatcct ctctttatcc tgttctgacc cctacttcag tcagatgaca 600 tgtttggtca tttctacatt caacgaggct tgcagcctcc tgattatcct ggcctcctat 660 atattcatag ttgtcaccat catcaagatg ccttctgctg gtggactcca gaaggccttc 720 tccacctgtg cctcccacct gaccgccatc accatcttcc atggaataat ccttcttctc 780 tactgtgtgc ccaactccaa aagctcgtgg ctcctggtca aagtggccac ggtgtttttt 840 actgtcatga tccccatgtt gaaccccctt atttacagcc tgaggaacaa agacgtgaaa 900 gacacagcca ggaagttaat ccataccaaa ctgctttctc actcaatgtg a 951

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069269_0225_SL.TXT <210> 834 <211> 316 <212> PRT <213> Canis familiaris <400> 834

Met Glu Leu Asp Glu Gly Asn Gln Ser Ser Val Thr Thr Phe Ile Leu 1 5 10 15 Leu Gly Phe Ser Glu Tyr Pro His Leu Gln Met Pro Leu Phe Leu Val 20 25 30 Phe Leu Thr Val Tyr Thr Val Thr Leu Val Gly Asn Leu Gly Ile Ile 35 40 45 Met Val Val Arg Ile Asn Pro Lys Leu His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ser His Leu Ser Phe Leu Asp Ile Cys Tyr Ser Ser Val Phe Thr 65 70 75 80 Pro Lys Leu Leu Glu Thr Leu Val Thr Glu Asp Arg Ser Ile Ser Phe 85 90 95 Lys Gly Cys Met Val Gln Phe Phe Phe Ile Cys Ala Phe Val Ile Thr 100 105 110 Glu Met Phe Met Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Val 115 120 125 Cys Asn Pro Leu Leu Tyr Thr Val Ala Met Ser Gln Lys Leu Cys Ala 130 135 140 Leu Leu Val Ala Gly Thr Tyr Thr Trp Gly Gly Ile Cys Ser Leu Thr 145 150 155 160 Leu Thr Tyr Ser Leu Leu Glu Leu Ser Tyr Cys Gly Ser Asn Ile Ile 165 170 175 Asn His Phe Gly Cys Glu Tyr Ser Ala Ile Leu Ser Leu Ser Cys Ser 180 185 190

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Asp Pro Tyr Phe Ser Gln Met Thr 200 Cys Leu Val Ile Ser 205 Thr Phe Asn 195 Glu Ala Cys Ser Leu Leu Ile Ile Leu Ala Ser Tyr Ile Phe Ile Val 210 215 220 Val Thr Ile Ile Lys Met Pro Ser Ala Gly Gly Leu Gln Lys Ala Phe 225 230 235 240 Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe His Gly Ile 245 250 255 Ile Leu Leu Leu Tyr Cys Val Pro Asn Ser Lys Ser Ser Trp Leu Leu 260 265 270 Val Lys Val Ala Thr Val Phe Phe Thr Val Met Ile Pro Met Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Thr Ala Arg 290 295 300 Lys Leu Ile His Thr Lys Leu Leu Ser His Ser Met

305 310 315 <210> 835 <211> 873 <212> DNA <213> Canis familiaris <400> 835

atgcccctgt tccttttatt ctttaccatc tacacagtta ttgttttggg aaatctgggc 60 atggtcatga ttatccagat caatcccaaa ctccataccc ccatgtactt cttcctcagc 120 catctttctt ttgttgattt ctgttactct acagtagtta cacccaaact attagaaaac 180 ttggttgtgg aagacagaac catctccttt ataggatgca ttatgcaatt cttctttgca 240 tgcatatttg tggtgacgga aacattcatg ttggcagtga tggcctatga tcgatatgtg 300 gcagtttgta acccactcct ctacacagtt gtcatgtctc agaagctttg ctccttattg 360

Page 940

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gtgagtgcat catactcctg gggtatagcc tgctccttaa catacacata ctttttgttg 420 accttatcct tttgtgggac taacttcata aataactttg tctgtgaaca tgctgccatt 480 gtctctgtgt cctgctctaa cccctacatt agccagaaga tcattttagt ctctgccacg 540 ttcaatgaaa taagcagctt gatgatcatt cttacctcct atgtttttat ctttatcact 600 gtcatgaaga tgccttcaac tggaggtcgc cacaaagtct tctcaacatg tgcctctcat 660 ctgactgcta ttacaatctt ccatgggacc atcctattcc tctactgtgt acctgactcc 720 agaagttcat ggctcatggt caaggtggct tctgtgtttt acactgtggt catccccatg 780 ctgaacccac tgatctacag tctcaggaac aaagatgtga aggagacagt aaagaagtta 840 attaatgtta aattgttctg tgacaaaata taa 873

<210> 836 <211> 290 <212> PRT <213> Canis familiaris <400> 836

Met Pro Leu Phe Leu Leu Phe Phe Thr Ile Tyr Thr Val Ile Val Leu 1 5 10 15 Gly Asn Leu Gly Met Val Met Ile Ile Gln Ile Asn Pro Lys Leu His 20 25 30 Thr Pro Met Tyr Phe Phe Leu Ser His Leu Ser Phe Val Asp Phe Cys 35 40 45 Tyr Ser Thr Val Val Thr Pro Lys Leu Leu Glu Asn Leu Val Val Glu 50 55 60 Asp Arg Thr Ile Ser Phe Ile Gly Cys Ile Met Gln Phe Phe Phe Ala 65 70 75 80 Cys Ile Phe Val Val Thr Glu Thr Phe Met Leu Ala Val Met Ala Tyr 85 90 95 Asp Arg Tyr Val Ala Val Cys Asn Pro Leu Leu Tyr Thr Val Val Met 100 105 110

Page 941

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Ser Gln Lys 115 Leu Cys Ser Leu Leu Val Ser Ala Ser Tyr Ser Trp Gly 120 125 Ile Ala Cys Ser Leu Thr Tyr Thr Tyr Phe Leu Leu Thr Leu Ser Phe 130 135 140 Cys Gly Thr Asn Phe Ile Asn Asn Phe Val Cys Glu His Ala Ala Ile 145 150 155 160 Val Ser Val Ser Cys Ser Asn Pro Tyr Ile Ser Gln Lys Ile Ile Leu 165 170 175 Val Ser Ala Thr Phe Asn Glu Ile Ser Ser Leu Met Ile Ile Leu Thr 180 185 190 Ser Tyr Val Phe Ile Phe Ile Thr Val Met Lys Met Pro Ser Thr Gly 195 200 205 Gly Arg His Lys Val Phe Ser Thr Cys Ala Ser His Leu Thr Ala Ile 210 215 220 Thr Ile Phe His Gly Thr Ile Leu Phe Leu Tyr Cys Val Pro Asp Ser 225 230 235 240 Arg Ser Ser Trp Leu Met Val Lys Val Ala Ser Val Phe Tyr Thr Val 245 250 255 Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp 260 265 270 Val Lys Glu Thr Val Lys Lys Leu Ile Asn Val Lys Leu Phe Cys Asp 275 280 285

Lys Ile 290 <210> 837 <211> 933 <212> DNA

Page 942

069269_0225_SL.TXT <213> Canis familiaris <400> 837 atggaaaata ggaataacat cacagaattt attcttttag gactttctca gaaaaaggaa 60 atagaagtcc tctgcttttt actgttctta ctctgttaca ttgcaatttt gattggaaac 120 ctacttgtca tgatttctat catctgcagt caacttatta accacccaat gtatttcttc 180 ttgagtttcc tatccctggc agacctttgt tacacctcca ctgtgacccc caagttaatc 240 attgacttgc tgtctgaaaa gaaggtcatt tcctacaatg gctgcatgac acagctcttt 300 accatgcact tctttggagg aattgaggtc ttcatcctca ccgggatggc ctatgaccgt 360 tatgtggcca tctgcaaacc cctgcactac accctcctca tgagccggtg gaaatgtgat 420 gccattcttg cagcttcctg tattggtgga ttccttcatt ccttcggtca gtttctcctt 480 gccatcgttt taccctactg tggccccaat gaaatagatc acttcttctg cgatgtgtac 540 cctttgctga agctggcttg caaggataca agcagaatcg gtcttctggt cgttgccaat 600 tcgggactga tgggtctggt gacttttgtc gtcttgctgg tatcttatgc tgtgatccta 660 tatactatca ggtcctactc tgcagagaat cgtcacaaag ctctttccac atgcagttcc 720 cacatcactg tggtggttct cttttttgct cctttactct ttatttatat tcgaccagca 780 actacattac cagaagacaa agtgtttgct cttttttaca ctgtctttgc ccctatgctc 840 aaccctctca tatacacact aagaaacatg gagatgaaga atgccataag gaaattttgg 900 tgccacgtca tgggaagtaa ggacataaac tga 933 <210> 838 <211> 310 <212> PRT <213> Canis familiaris <400> 838

Met 1 Glu Asn Arg Asn Asn Ile Thr Glu Phe Ile Leu Leu Gly Leu Ser 5 10 15 Gln Lys Lys Glu Ile Glu Val Leu Cys Phe Leu Leu Phe Leu Leu Cys 20 25 30 Tyr Ile Ala Ile Leu Ile Gly Asn Leu Leu Val Met Ile Ser Ile Ile 35 40 45

Page 943

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Cys Ser 50 Gln Leu Ile Asn His Pro 55 Met Tyr Phe Phe Leu Ser Phe 60 Leu Ser Leu Ala Asp Leu Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Ile 65 70 75 80 Ile Asp Leu Leu Ser Glu Lys Lys Val Ile Ser Tyr Asn Gly Cys Met 85 90 95 Thr Gln Leu Phe Thr Met His Phe Phe Gly Gly Ile Glu Val Phe Ile 100 105 110 Leu Thr Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Leu Leu Met Ser Arg Trp Lys Cys Asp Ala Ile Leu Ala 130 135 140 Ala Ser Cys Ile Gly Gly Phe Leu His Ser Phe Gly Gln Phe Leu Leu 145 150 155 160 Ala Ile Val Leu Pro Tyr Cys Gly Pro Asn Glu Ile Asp His Phe Phe 165 170 175 Cys Asp Val Tyr Pro Leu Leu Lys Leu Ala Cys Lys Asp Thr Ser Arg 180 185 190 Ile Gly Leu Leu Val Val Ala Asn Ser Gly Leu Met Gly Leu Val Thr 195 200 205 Phe Val Val Leu Leu Val Ser Tyr Ala Val Ile Leu Tyr Thr Ile Arg 210 215 220 Ser Tyr Ser Ala Glu Asn Arg His Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Ile Thr Val Val Val Leu Phe Phe Ala Pro Leu Leu Phe Ile Tyr 245 250 255

Page 944

069269_0225_SL.TXT

Ile Arg Pro Ala 260 Thr Thr Leu Pro Glu Asp Lys Val Phe Ala Leu Phe 265 270 Tyr Thr Val Phe Ala Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Met Glu Met Lys Asn Ala Ile Arg Lys Phe Trp Cys His Val Met 290 295 300 Gly Ser Lys Asp Ile Asn

305 310 <210> 839 <211> 939 <212> DNA <213> Canis familiaris <400> 839

atggaaaata ggaacaatgt tactgaattt attctcttgg gactttctaa gaataagaaa 60 gtccaaatcc tctgcttttt atttttctta ctctgttatc tagctatctg gttggggaat 120 ttgattatta tggcttccat cacatgcagt cagctaatta atcagcccat gtatttcttc 180 cttaattacc ttgccctctc agacctcctc tatacctcca ctgtgacacc caaactaatg 240 acagacttac tgacagagaa taaggtcatt tcctataaaa actgcatgac acagctattt 300 actacacatt tctttggagg ggttgaggtc ttcatcatca caggaatggc ctatgatcgc 360 tatgtggcca tctgcaaacc actccactat gccatcctca tgaataggca aagatgtaac 420 tcaattctca gagcatcatg tgcagggggg tttctgcatt cccttggcct gtttcttctt 480 acaatttttt tacctttttg tggacccaat gaaatagatc actatttctg tgatgtgtat 540 cctttgttga aactggcatg cattgataca cacaaaattg gtttcttagt cattgccaat 600 tctggcctga tgggactggt gatctttgtg gttttgatgg cctcctactt tatgatatta 660 tataatgtga gagcatattc tgcagagaac cgccacaagg cgctttccac ttgcagctcc 720 cacatcacag ttgtgatcct gttttttgca cctgtcatct ttgtttacat taggcctgcc 780 acaactttac cagaggataa agtatttaca ctcttctaca caattatcgt ccccatgctc 840

Page 945

900

939

069269_0225_SL.TXT aatcctctta tctatacact tagaaacaca gagatgaaaa atgccataag gaaagtttgg tgcactgaaa ggttttggaa agggaaacca atgatttga <210> 840 <211> 312 <212> PRT <213> Canis familiaris <400> 840

Met Glu Asn Arg Asn Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15 Lys Asn Lys Lys Val Gln Ile Leu Cys Phe Leu Phe Phe Leu Leu Cys 20 25 30 Tyr Leu Ala Ile Trp Leu Gly Asn Leu Ile Ile Met Ala Ser Ile Thr 35 40 45 Cys Ser Gln Leu Ile Asn Gln Pro Met Tyr Phe Phe Leu Asn Tyr Leu 50 55 60 Ala Leu Ser Asp Leu Leu Tyr Thr Ser Thr Val Thr Pro Lys Leu Met 65 70 75 80 Thr Asp Leu Leu Thr Glu Asn Lys Val Ile Ser Tyr Lys Asn Cys Met 85 90 95 Thr Gln Leu Phe Thr Thr His Phe Phe Gly Gly Val Glu Val Phe Ile 100 105 110 Ile Thr Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Ala Ile Leu Met Asn Arg Gln Arg Cys Asn Ser Ile Leu Arg 130 135 140 Ala Ser Cys Ala Gly Gly Phe Leu His Ser Leu Gly Leu Phe Leu Leu 145 150 155 160 Thr Ile Phe Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe

Page 946

069269_0225_SL.TXT 165 170

Cys Asp Val Tyr 180 Pro Leu Leu Lys Leu Ala Cys Ile Asp 185 Thr 190 Ile Gly Phe Leu Val Ile Ala Asn Ser Gly Leu Met Gly Leu 195 200 205 Phe Val Val Leu Met Ala Ser Tyr Phe Met Ile Leu Tyr Asn 210 215 220 Ala Tyr Ser Ala Glu Asn Arg His Lys Ala Leu Ser Thr Cys 225 230 235 His Ile Thr Val Val Ile Leu Phe Phe Ala Pro Val Ile Phe 245 250 Ile Arg Pro Ala Thr Thr Leu Pro Glu Asp Lys Val Phe Thr 260 265 270 Tyr Thr Ile Ile Val Pro Met Leu Asn Pro Leu Ile Tyr Thr 275 280 285 Asn Thr Glu Met Lys Asn Ala Ile Arg Lys Val Trp Cys Thr 290 295 300 Phe Trp Lys Gly Lys Pro Met Ile 305 310

175

His Lys

Val Ile

Val Arg

Ser Ser 240

Val Tyr 255

Leu Phe

Leu Arg

Glu Arg <210> 841 <211> 942 <212> DNA <213> Canis familiaris <400> 841 atggaaaata ttaataatgt cactgaattt gttctgttgg gactttccca gttaaaaact tatgctttct attattctta ttttgttaca tagctatttg ttgctcataa tgatttctat cacatgcagt cagctaattg accaacccat cttaataatc ttgccctctc agatctgtgt tatacctcaa cagtgacacc Page 947 gaataagaaa gatgggaaac gtatttcttc caagctagtc

120

180

240

069269_0225_SL.TXT actgacttgc tggtagaaag taacatgatt gtcatgcatt tctttggggg gattgaagtc tacgtggcca tctgcaagcc cttgcactac ggcatagtca ttgctagctg tactggggca accatcactt tacctttctg tggccccaat cctttgctga aactggcctg cacagatacc tccggcatga tgggcttggt gacctttgta tacaccatca agtcttaccc tgcagagagc catatcacag ttgtggttct gttctttgtg acaacttttc cagaagacaa agtgtttgct aaccctctga tttacacatt aagaaacatg tgccagaaac catgtttgat tggaaagcaa <210> 842 <211> 313 <212> PRT <213> Canis familiaris <400> 842

Met Glu Asn Ile Asn Asn Val Thr 1 5 Gln Asn Lys Lys Val Lys Asn Leu 20 Tyr Ile Ala Ile Trp Met Gly Asn 35 40 Cys Ser Gln Leu Ile Asp Gln Pro 50 55 Ala Leu Ser Asp Leu Cys Tyr Thr 65 70

Glu Phe 10 Val Leu Leu Gly Leu 15 Ser Cys 25 Phe Leu Leu Phe Leu 30 Phe Cys Leu Leu Ile Met Ile 45 Ser Ile Thr Met Tyr Phe Phe 60 Leu Asn Asn Leu Ser Thr Val 75 Thr Pro Lys Leu Val 80

tcttatacta actgtatggc acagcttttt tttatcctca cggggatggc ctatgaccgc accgtcatca tgaacagaaa gagatgttat tttctgcatt cttttgtcca atgtctcctt gagatagatc actacttttg tgatgtgtat tacagagttg ggatcttagt ggttgccaat gtcttggttc tatcctactt attgatatta cgcaccaaag ctctttccac ctgcagctcc cctgttctct tcatttacat tcgcccagcc cttttctaca ccatcattgc tcccatgttc gagatgaaaa ataccttgag gaaagtgtgg atcattatat aa

300

360

420

480

540

600

660

720

780

840

900

942

Page 948

Thr Asp Leu Leu Val 85 Glu Ser 069269_0225_SL.TXT Asn Met Ile Ser Tyr Thr 90 Asn Cys 95 Met Ala Gln Leu Phe Val Met His Phe Phe Gly Gly Ile Glu Val Phe Ile 100 105 110 Leu Thr Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Val Ile Met Asn Arg Lys Arg Cys Tyr Gly Ile Val Ile 130 135 140 Ala Ser Cys Thr Gly Ala Phe Leu His Ser Phe Val Gln Cys Leu Leu 145 150 155 160 Thr Ile Thr Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Val Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr Tyr Arg 180 185 190 Val Gly Ile Leu Val Val Ala Asn Ser Gly Met Met Gly Leu Val Thr 195 200 205 Phe Val Val Leu Val Leu Ser Tyr Leu Leu Ile Leu Tyr Thr Ile Lys 210 215 220 Ser Tyr Pro Ala Glu Ser Arg Thr Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Ile Thr Val Val Val Leu Phe Phe Val Pro Val Leu Phe Ile Tyr 245 250 255 Ile Arg Pro Ala Thr Thr Phe Pro Glu Asp Lys Val Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285

Page 949

069269_0225_SL.TXT

Asn Met Glu Met Lys Asn Thr Leu Arg Lys Val Trp Cys Gln Lys Pro 290 295 300

Cys Leu Ile Gly Lys Gln Ile Ile Ile 305 310 <210> 843 <211> 984 <212> DNA <213> Canis familiaris <400> 843

atggaaaata ggaacaacat cactatgttt attctcttgg gactgtctca aaacaagaac 60 attgaaatct tctgctttgt attattttta ttttgctacc ttgctatttg ggtgggaaat 120 ttgctcataa tgatttctat catgtgcagt cagctaattg agcaacccat gtatttcttc 180 cttaattacc tctcactctc tgacctttgc tacacatcaa cagtgacacc taaactacta 240 actgatttac tggcagaaag gaagatcatt tcctacagta actgcatgac acagcttttt 300 attctgcact ttcttggagg tgttgagatc ttcgtcctca cagggatggc ctatgaccgc 360 tacgtggcca tctgcaagcc cctacactac accatcatca tgagcagaca gagatgcaat 420 gcaatcatca cagcctgttg tacgggggcg tttatacact ccgccagtca gttccttctc 480 accatcttcc tcccgttctg tggccccaat gagatagatc actacttctg tgatgtgtat 540 cctttactga agctggcctg cactgacaca cgtagaattg gtctcttggt aattgttaat 600 tcaggtctga tcgctctgct gacttttgtg attttgatgg tgtcctattt tctgatatta 660 tacaccatca tggcctaccc tgcagagagc cgcaccaaag ctctttccac ttgcagttcc 720 catatcacag ttgtggttct gttctttgtg ccagttctct tcatttacat tcgcccagcc 780 acaacttttc cagaagacaa agtgtttgct cttttctaca ccatcattgc tcctatgttc 840 aatcctctaa tctacaccct gagaaacatg gagatgaaga atgccttgag gaaagtgtgg 900 tgtcatcgtt tatttttgga agggagggaa ctcatattaa aagcattcca gaatttcact 960 ttaggattct accctgagcc ctaa 984

<210> 844 <211> 327 <212> PRT

Page 950

069269_0225_SL.TXT <213> Canis familiaris <400> 844

Met 1 Glu Asn Arg Asn 5 Asn Ile Thr Met Phe Ile Leu Leu Gly Leu Ser 10 15 Gln Asn Lys Asn Ile Glu Ile Phe Cys Phe Val Leu Phe Leu Phe Cys 20 25 30 Tyr Leu Ala Ile Trp Val Gly Asn Leu Leu Ile Met Ile Ser Ile Met 35 40 45 Cys Ser Gln Leu Ile Glu Gln Pro Met Tyr Phe Phe Leu Asn Tyr Leu 50 55 60 Ser Leu Ser Asp Leu Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Leu 65 70 75 80 Thr Asp Leu Leu Ala Glu Arg Lys Ile Ile Ser Tyr Ser Asn Cys Met 85 90 95 Thr Gln Leu Phe Ile Leu His Phe Leu Gly Gly Val Glu Ile Phe Val 100 105 110 Leu Thr Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Ile Ile Met Ser Arg Gln Arg Cys Asn Ala Ile Ile Thr 130 135 140 Ala Cys Cys Thr Gly Ala Phe Ile His Ser Ala Ser Gln Phe Leu Leu 145 150 155 160 Thr Ile Phe Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Val Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr Arg Arg 180 185 190 Ile Gly Leu Leu Val Ile Val Asn Ser Gly Leu Ile Ala Leu Leu Thr

Page 951

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195 200 205 Phe Val Ile Leu Met Val Ser Tyr Phe Leu Ile Leu Tyr Thr Ile Met 210 215 220 Ala Tyr Pro Ala Glu Ser Arg Thr Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Ile Thr Val Val Val Leu Phe Phe Val Pro Val Leu Phe Ile Tyr 245 250 255 Ile Arg Pro Ala Thr Thr Phe Pro Glu Asp Lys Val Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Met Glu Met Lys Asn Ala Leu Arg Lys Val Trp Cys His Arg Leu 290 295 300 Phe Leu Glu Gly Arg Glu Leu Ile Leu Lys Ala Phe Gln Asn Phe Thr 305 310 315 320 Leu Gly Phe Tyr Pro Glu Pro

325 <210> 845 <211> 957 <212> DNA <213> Canis familiaris <400> 845

atggaaagtc agaggaacat ctcagaattc attcttttgg gcctttccta taaccagaac 60 atacaaatat tttgtttcat tttcttctta ttttgttatg tttccatctt ggtgggaaat 120 cttctaattc ttgtctccat tctatgcagt ggcctttttt accaaccaat gtactatttt 180 ctcaaccact tatcctttat ggacatttgc tacacctcct gtgtgatacc caaactgatt 240 ggtgacctac tactggttag aaaaaccatc tcttatgata actgtatgtc acaggtcttt 300 tccttgcact tcttgggaat gattgaaatc ttcatcctta cagtcatggc ctttgatcgc 360

Page 952

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tatgctgcca tctgcaaacc tctccactac atgattatta tgaacaggac aagatgcaat 420 ctcctagtca tggctgcttg ggttggtgga gctgtccatt ctttttctca gttttctatg 480 ataatctgtt tgcccttctg tggccccaat gaaatcaatc actactattg tgatatcttc 540 cctttgctga aaattgcctg tactgatacc tatgtcattg gtgtcattgt ggttgccaat 600 tcaggaatgg ttgctttagt aacctttgtt ctcttgtttg ggtcttatgt tgttatacta 660 ttcactttaa gaaattactc agctgaggga agacgcaaag ctctctctac ctgtgggtct 720 catatcacgg tggtcatctt attttttggg ccttcaatct ttgcctacct cagacctcct 780 accactttcc ctgaggacaa aatatttgca ctattttata ccgtcattgt tcctatgttc 840 aatcctttaa tctatactct gagaaataca gaaaaaagcc atgagaaggg tttggtgtca 900 aaggatattt tcagaagaca aacacaattg atttgtccta ctcaatatgc tgaataa 957

<210> 846 <211> 318 <212> PRT <213> Canis familiaris <400> 846

Met Glu Ser Gln Arg Asn Ile Ser Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15 Tyr Asn Gln Asn Ile Gln Ile Phe Cys Phe Ile Phe Phe Leu Phe Cys 20 25 30 Tyr Val Ser Ile Leu Val Gly Asn Leu Leu Ile Leu Val Ser Ile Leu 35 40 45 Cys Ser Gly Leu Phe Tyr Gln Pro Met Tyr Tyr Phe Leu Asn His Leu 50 55 60 Ser Phe Met Asp Ile Cys Tyr Thr Ser Cys Val Ile Pro Lys Leu Ile 65 70 75 80 Gly Asp Leu Leu Leu Val Arg Lys Thr Ile Ser Tyr Asp Asn Cys Met 85 90 95

Page 953

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Ser Gln Val Phe 100 Ser Leu His Phe Leu Gly Met Ile Glu Ile Phe Ile 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Ile Ile Met Asn Arg Thr Arg Cys Asn Leu Leu Val Met 130 135 140 Ala Ala Trp Val Gly Gly Ala Val His Ser Phe Ser Gln Phe Ser Met 145 150 155 160 Ile Ile Cys Leu Pro Phe Cys Gly Pro Asn Glu Ile Asn His Tyr Tyr 165 170 175 Cys Asp Ile Phe Pro Leu Leu Lys Ile Ala Cys Thr Asp Thr Tyr Val 180 185 190 Ile Gly Val Ile Val Val Ala Asn Ser Gly Met Val Ala Leu Val Thr 195 200 205 Phe Val Leu Leu Phe Gly Ser Tyr Val Val Ile Leu Phe Thr Leu Arg 210 215 220 Asn Tyr Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Ser Ile Phe Ala Tyr 245 250 255 Leu Arg Pro Pro Thr Thr Phe Pro Glu Asp Lys Ile Phe Ala Leu Phe 260 265 270 Tyr Thr Val Ile Val Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Thr Glu Lys Ser His Glu Lys Gly Leu Val Ser Lys Asp Ile Phe 290 295 300

Page 954

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Arg Arg Gln Thr Gln Leu Ile Cys Pro Thr Gln Tyr Ala Glu 305 310 315 <210> 847 <211> 930 <212> DNA <213> Canis familiaris <400> 847

atggatcaaa gcaataacgt cactgtattc attctcttgg gactttccaa aaacaagaac 60 attgaaatcc tttgttttgt attattttta ttctgctacc ttgctatttg gataggaaac 120 ctgcttataa tgatttctat catgtgcagt cagctaattg agcaacccat gtatttcttc 180 cttaattacc tctccgtctc cgacctttgt tacacatcca ctgtgacacc caagctaatg 240 actgacttat tggcagaaag gaagaccatt tcctacagta actgcatgac acaactcttt 300 accacacatt tatttggagg catcgagatc ttcattctca cagggatggc ctatgaccgc 360 tatgtggcca tctgcaaacc cctgcactac accatcatca tgagcagaca gagatgtaat 420 gcaatcatcg cagcctgctg tacgggggcg tttatacatt ccaccagtca gttccttctc 480 accatcttcc tgccgttctg tggccccaat gagatagatc actacttctg tgatgtgtat 540 cctttactga agctggcctg ttctaataca cacgccatag gtctcttagt cattgctaat 600 tcaggcctaa ttgctttggt gacctttgct gtgctgacgc tgtcttattg ttttatactg 660 tgcagcatca gggcatattc tgcacagagt cgcagcaaag ctcttgccac ctgcacttct 720 cacctcacag tcgtggttct attttttgca cctgcactgt tcatttacct tcgcccagcc 780 acaactttcc cagaagacaa agtgttggct cttttctaca ccatcattgc ccccatgttc 840 aatcctctga tctacacgct gagaaacacg gagatgaaga atgccttgag gaaagtgtgg 900 tgtcatcatg cactcctaga aggaaagtaa 930

<210> 848 <211> 309 <212> PRT <213> Canis familiaris <400> 848

Met Asp Gln Ser Asn Asn Val Thr Val Phe Ile Leu Leu Gly Leu Ser 1 5 10 15

Page 955

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Lys Asn Lys Asn 20 Ile Glu Ile Leu Cys Phe Val Leu Phe Leu Phe Cys 25 30 Tyr Leu Ala Ile Trp Ile Gly Asn Leu Leu Ile Met Ile Ser Ile Met 35 40 45 Cys Ser Gln Leu Ile Glu Gln Pro Met Tyr Phe Phe Leu Asn Tyr Leu 50 55 60 Ser Val Ser Asp Leu Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Met 65 70 75 80 Thr Asp Leu Leu Ala Glu Arg Lys Thr Ile Ser Tyr Ser Asn Cys Met 85 90 95 Thr Gln Leu Phe Thr Thr His Leu Phe Gly Gly Ile Glu Ile Phe Ile 100 105 110 Leu Thr Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Ile Ile Met Ser Arg Gln Arg Cys Asn Ala Ile Ile Ala 130 135 140 Ala Cys Cys Thr Gly Ala Phe Ile His Ser Thr Ser Gln Phe Leu Leu 145 150 155 160 Thr Ile Phe Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Val Tyr Pro Leu Leu Lys Leu Ala Cys Ser Asn Thr His Ala 180 185 190 Ile Gly Leu Leu Val Ile Ala Asn Ser Gly Leu Ile Ala Leu Val Thr 195 200 205 Phe Ala Val Leu Thr Leu Ser Tyr Cys Phe Ile Leu Cys Ser Ile Arg 210 215 220

Page 956

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Ala Tyr 225 Ser Ala Gln Ser Arg Ser Lys Ala Leu Ala Thr Cys Thr Ser 230 235 240 His Leu Thr Val Val Val Leu Phe Phe Ala Pro Ala Leu Phe Ile Tyr 245 250 255 Leu Arg Pro Ala Thr Thr Phe Pro Glu Asp Lys Val Leu Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Thr Glu Met Lys Asn Ala Leu Arg Lys Val Trp Cys His His Ala 290 295 300 Leu Leu Glu Gly Lys

305 <210> 849 <211> 846 <212> DNA <213> Canis familiaris <400> 849

aataatatga ataaattttt ctgcttaggt tgatccagga agaaagtagt gtttgtcact 60 tttttgcttt tcttcttggg gatgtagttg ggtaactttc tgattattac tactttcaag 120 tccagccggg cactcgggag tctggtatac ttcttccttt tccatttatc ctcatctgac 180 acctgcttct gtactcccat agcccctaga atgattatgg atgtcctttt gaagaagacc 240 actgtctctt tcagtaagaa catgatacaa attttttcat tccgtttctt tggctccctg 300 gagatcttca tcctcatcct catgactgct gaccactatg tggccatctg taagaccttg 360 cactacacaa ccatcatacg ttgacggatc tgtgctgtgc tggtggctat ggcctgggtg 420 gggtcctgtg cacattcttt agttcagaca tttctggcct tgagtttacc gctccatggt 480 ctcagtgtga ttgattgcta tctttgtgac ttgcagcttt tgttgaaact tgcctgtgca 540 gacacctatg tgatcaatct acttctggtg tcccaaagtg gggccatttg tacattgagt 600 tttgtcatgc tgatgtgctc ctatgttata tataaccttg cagtctctga aaaccacagt 660

Page 957

069269_0225_SL.TXT gctgagggga ggagaaaagc cctctcctac atcattgtgg tcatcttgtt ctttggtcct tgtacattta tatacataca tcctgcaacc accttctctg tgattaagat aatagctttg ttttatataa ttggaatacc tttgctcaac cctctgattt atactctaag gaatgcagaa gtgaaa

720

780

840

846 <210> 850 <211> 146 <212> PRT <213> Canis familiaris <400> 850

Met Ala Trp Val 1 Gly 5 Ser Cys Ala His Ser Leu Val Gln Thr Phe Leu 10 15 Ala Leu Ser Leu Pro Leu His Gly Leu Ser Val Ile Asp Cys Tyr Leu 20 25 30 Cys Asp Leu Gln Leu Leu Leu Lys Leu Ala Cys Ala Asp Thr Tyr Val 35 40 45 Ile Asn Leu Leu Leu Val Ser Gln Ser Gly Ala Ile Cys Thr Leu Ser 50 55 60 Phe Val Met Leu Met Cys Ser Tyr Val Ile Tyr Asn Leu Ala Val Ser 65 70 75 80 Glu Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Tyr Ile Ile 85 90 95 Val Val Ile Leu Phe Phe Gly Pro Cys Thr Phe Ile Tyr Ile His Pro 100 105 110 Ala Thr Thr Phe Ser Val Ile Lys Ile Ile Ala Leu Phe Tyr Ile Ile 115 120 125 Gly Ile Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Ala Glu 130 135 140

Page 958

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Val Lys

145 <210> 851 <211> 936 <212> DNA <213> Canis familiaris <400> 851

atggagcggc agagaaacat ctcagaattc attcttctag gactttcata tgaccagaac 60 atgcaaatat tttgctttgt actcttctta ttctgttata ttgccctgtt ggtaggaaac 120 cttctaatcc ttgtctccat tcgatgcagc cctctttttc accaaccaat gtactacttc 180 ctcagccatt tatcctctat ggacatctgc tatacctcta gcgttacacc caaattaatt 240 gctgacctac taggggggac taaaaccatc tcttatggta attgcatgtt acaagttttt 300 gccatgcact tctttgggag tattgaggtc tttgtcctta ctgtcatggc ctttgatcgc 360 tatgttgcta tttgcaggcc tctccactac atgcttatca tgaacagggc aaggtgccat 420 ctcctagtct tagctgcttg ggctggtggg gctcttcatt cttttcctca attatcaatg 480 acaatccaat tgccattttg tggtcctaat gaaatcgatc actacttttg tgatatcttc 540 cctttgctga aagttgcctg cactgatact tacatcattg gtgtccttgt ggttgccaat 600 tcaggtatgg ttgccttagt tacctttgtt gtcttatttg tttcttatgt cattatattg 660 tttagtctaa gacatcactc agctgaggga agacacaaag ccctttccac ctgtgggtct 720 catatcactg ttgtcatctt attctttggg ccttcaatct ttgcctacct acgacctcca 780 actactttcc ctgaggacaa agtatttgct ctattttata ccatcatcgc tcctatgttc 840 aatcccttaa tctatactct gagaaatgca gaaatgaaaa atgccatgac aaaagtttgg 900 tgtcaaacat tattttcaag gaaagcacac aattaa 936

<210> 852 <211> 311 <212> PRT <213> Canis familiaris <400> 852

Met Glu Arg Gln Arg Asn Ile Ser Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15

Page 959

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Tyr Asp Gln Asn 20 Met Gln Ile Phe Cys Phe Val Leu Phe Leu Phe Cys 25 30 Tyr Ile Ala Leu Leu Val Gly Asn Leu Leu Ile Leu Val Ser Ile Arg 35 40 45 Cys Ser Pro Leu Phe His Gln Pro Met Tyr Tyr Phe Leu Ser His Leu 50 55 60 Ser Ser Met Asp Ile Cys Tyr Thr Ser Ser Val Thr Pro Lys Leu Ile 65 70 75 80 Ala Asp Leu Leu Gly Gly Thr Lys Thr Ile Ser Tyr Gly Asn Cys Met 85 90 95 Leu Gln Val Phe Ala Met His Phe Phe Gly Ser Ile Glu Val Phe Val 100 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125 His Tyr Met Leu Ile Met Asn Arg Ala Arg Cys His Leu Leu Val Leu 130 135 140 Ala Ala Trp Ala Gly Gly Ala Leu His Ser Phe Pro Gln Leu Ser Met 145 150 155 160 Thr Ile Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Ile Phe Pro Leu Leu Lys Val Ala Cys Thr Asp Thr Tyr Ile 180 185 190 Ile Gly Val Leu Val Val Ala Asn Ser Gly Met Val Ala Leu Val Thr 195 200 205 Phe Val Val Leu Phe Val Ser Tyr Val Ile Ile Leu Phe Ser Leu Arg 210 215 220

Page 960

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His His 225 Ser Ala Glu Gly 230 Arg His Lys Ala Leu 235 Ser Thr Cys Gly Ser 240 His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Ser Ile Phe Ala Tyr 245 250 255 Leu Arg Pro Pro Thr Thr Phe Pro Glu Asp Lys Val Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Met Lys Asn Ala Met Thr Lys Val Trp Cys Gln Thr Leu 290 295 300 Phe Ser Arg Lys Ala His Asn

305 310 <210> 853 <211> 927 <212> DNA <213> Canis familiaris <400> 853

ctaatgatgg gaaaccagac atcagtgata gaattcattc ttcttggact gatgaatgac 60 actgaacttc aagctgtgct tttccttttt ctgctgctaa cttatgtctt aaacatcatg 120 ggaaacttta ccatcatcat tctgaccctt ttggattatc gccttcagac tcctatgtat 180 ttctttctcc ggaatttttt tattttggaa atatctttta cttctgtctt tgttcccaaa 240 atgctagtca atattgcaac tggagacaag actatctcct tcgctggttg tttcactaag 300 tatttttttg ccatccttct gggggcaact gaattttatc ttttagctgc catgttctat 360 gattgctatg ttgccatttg taaacccctg cattatacaa ctgtaatgag caggaaactg 420 tgcgttcagc ttgttctgtg ttcctggttc tctggttttt tggttgtcat tgtgccacat 480 acaatgactc tccaactgcc tttctgtgcc tacaatgtca tcaatcactg ttgctgtgag 540 tataccatac tgctgcatct gtcctgttca gacacacagt tcatagaagt gatggagttt 600 atctttgcag cagttaccct catcttcacc ttggtgctag tgattctttc ctacacgtac 660

Page 961

069269_0225_SL.TXT ataatcagga caattctgag aatcccttct gttcaacaaa gaaaaaaagc cttttctaca tgctcctgtc acatgattgt ggtctcactt tcttatggaa gttgtatctt tatgtacata aatccttctg ttaaggatgc agaaactttt aataagagag tggctgtttt aaatacctca gttgcccctc tgttgaaccc tttcatctat accctaagga aaaagcaagt gaaaatagcc ttcaaagaca tggtcagcaa gataatg

720

780

840

900

927 <210> 854 <211> 308 <212> PRT <213> Canis familiaris <400> 854

Met Met Gly 1 Asn Gln Thr Ser Val 5 Ile Glu Phe Ile Leu Leu Gly Leu 10 15 Met Asn Asp Thr Glu Leu Gln Ala Val Leu Phe Leu Phe Leu Leu Leu 20 25 30 Thr Tyr Val Leu Asn Ile Met Gly Asn Phe Thr Ile Ile Ile Leu Thr 35 40 45 Leu Leu Asp Tyr Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn 50 55 60 Phe Phe Ile Leu Glu Ile Ser Phe Thr Ser Val Phe Val Pro Lys Met 65 70 75 80 Leu Val Asn Ile Ala Thr Gly Asp Lys Thr Ile Ser Phe Ala Gly Cys 85 90 95 Phe Thr Lys Tyr Phe Phe Ala Ile Leu Leu Gly Ala Thr Glu Phe Tyr 100 105 110 Leu Leu Ala Ala Met Phe Tyr Asp Cys Tyr Val Ala Ile Cys Lys Pro 115 120 125 Leu His Tyr Thr Thr Val Met Ser Arg Lys Leu Cys Val Gln Leu Val 130 135 140

Page 962

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Leu 145 Cys Ser Trp Phe Ser Gly Phe Leu Val Val Ile Val Pro His Thr 150 155 160 Met Thr Leu Gln Leu Pro Phe Cys Ala Tyr Asn Val Ile Asn His Cys 165 170 175 Cys Cys Glu Tyr Thr Ile Leu Leu His Leu Ser Cys Ser Asp Thr Gln 180 185 190 Phe Ile Glu Val Met Glu Phe Ile Phe Ala Ala Val Thr Leu Ile Phe 195 200 205 Thr Leu Val Leu Val Ile Leu Ser Tyr Thr Tyr Ile Ile Arg Thr Ile 210 215 220 Leu Arg Ile Pro Ser Val Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Cys His Met Ile Val Val Ser Leu Ser Tyr Gly Ser Cys Ile Phe 245 250 255 Met Tyr Ile Asn Pro Ser Val Lys Asp Ala Glu Thr Phe Asn Lys Arg 260 265 270 Val Ala Val Leu Asn Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile 275 280 285 Tyr Thr Leu Arg Lys Lys Gln Val Lys Ile Ala Phe Lys Asp Met Val 290 295 300 Ser Lys Ile Met

305 <210> 855 <211> 735 <212> DNA <213> Canis familiaris <400> 855

Page 963

069269_0225_SL.TXT cctatgtatt tctttctttg aaatttttct ttcttagaaa tttcttatac gacagtctgc 60 atccccaaat tgcttgtaag catggccact ggtgacaaaa ccatttcctt taactgttgt 120 gcaactcagt tgtttgcctt ccttcttgga gcatctgaat gttacctcct ggctgtcatg 180 tcctacaatc gttatgtagc catctgcaag cccctgcatt acacaaccat tatgagcagc 240 aaaatctgta tccagctagt tcttagctct tggatcactg gtttcctcat catctttcca 300 ggactcattt taggcttaag cctggacttc tgtgattcca atgtcattga tcatttctac 360 tgtgacactg ctcccctcct gcagatctcc tgcacagaca gacacgtgtt ggaaatgatg 420 agtttcatct tagctttggt gactctgctg gtcactttgg cattagtaat tctatcatac 480 acatatattg ccctaacaat tttaaaaatt ccttctgcca accagagaaa aaagaaaaaa 540 gctttctcca cctgttcttc tcacatgatt gtcatctccc tctcatatgg cagctgcatc 600 tttatgtacc ttaaaccctc agtcaaacag aggatatcct tgatgaaggg agtggcagtt 660 ctcaatactt ctgttgctcc acttttgaat ccctttattt atactctaag gaaacagcag 720 gtgaagcaag cattt 735 <210> 856 <211> 218 <212> PRT <213> Canis familiaris <400> 856

Met Ala Thr Gly Asp Lys Thr Ile Ser Phe Asn Cys Cys Ala Thr Gln 1 5 10 15 Leu Phe Ala Phe Leu Leu Gly Ala Ser Glu Cys Tyr Leu Leu Ala Val 20 25 30 Met Ser Tyr Asn Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Thr 35 40 45 Thr Ile Met Ser Ser Lys Ile Cys Ile Gln Leu Val Leu Ser Ser Trp 50 55 60 Ile Thr Gly Phe Leu Ile Ile Phe Pro Gly Leu Ile Leu Gly Leu Ser 65 70 75 80

Page 964

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Leu Asp Phe Cys Asp Ser Asn Val Ile Asp His Phe Tyr Cys Asp Thr 85 90 95 Ala Pro Leu Leu Gln Ile Ser Cys Thr Asp Arg His Val Leu Glu Met 100 105 110 Met Ser Phe Ile Leu Ala Leu Val Thr Leu Leu Val Thr Leu Ala Leu 115 120 125 Val Ile Leu Ser Tyr Thr Tyr Ile Ala Leu Thr Ile Leu Lys Ile Pro 130 135 140 Ser Ala Asn Gln Arg Lys Lys Lys Lys Ala Phe Ser Thr Cys Ser Ser 145 150 155 160 His Met Ile Val Ile Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met Tyr 165 170 175 Leu Lys Pro Ser Val Lys Gln Arg Ile Ser Leu Met Lys Gly Val Ala 180 185 190 Val Leu Asn Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr Thr 195 200 205 Leu Arg Lys Gln Gln Val Lys Gln Ala Phe 210 215

<210> 857 <211> 945 <212> DNA <213> Canis familiaris <400> 857

atgaaaaacc attcaacaga aatagagttt attctcataa gactgacaga tgacccacaa 60 ttgcaagttg tgatttttgt gtttttattt cttaattaca cattgagcct gatgaggaac 120 ttaaccatta tcctcctcac tctgctggat cctcacctca agatgccaat gtatttcttt 180 ctccataatt tctcattttt agaaatcata ttcacaatgg tatgtattcc cagatacttg 240 aaaaccatag tgactaaaga aaaaaacatt tcatataata actgtgtgac tcaattattt 300

Page 965

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tttattcttt tactgggagt tgcagagttt taccttctgg ctgctatgtc ctatgaccgc 360 tatgttgcca tctgtaaacc cttgcattac ccaatcatta tgaacagcag agtgtgctat 420 tggcttgtac tttcttcctg gctgactgga ttcctaatta tctttacccc tttgctcatg 480 ggactcaagc tggatttctc tgcttccaaa gcgattgatc actttatgtg tgaaacttcc 540 cccatcctgc agatatcctg cacagacaca catgtcctag aattgatgtc tttcatcttc 600 gctgtggtga cacttgtggt cacattggtg ttagtggttc tctcctacac ttgcatcatg 660 aagaccatta tgaaattccc ttctgcacag caaaggacca aagctttttc cgcctgtact 720 tcccatatga ttgttgtctc catgacatat gggagctgca tctttatgta tattaagcca 780 tctgccaaag aaagggtgac tgtatccaaa gatgtagctt tgctgtatac ctcaattgcc 840 cctttactaa atcccttcat ttatacccta aggaatcagc aggtgaaaga aatcttttgg 900 gatatgttac aaaaaaggtt gtgtttttca aaaaaactgt tgtaa 945

<210> 858 <211> 314 <212> PRT <213> Canis familiaris <400> 858

Met 1 Lys Asn His Ser 5 Thr Glu Ile Glu Phe Ile Leu Ile Arg Leu Thr 10 15 Asp Asp Pro Gln Leu Gln Val Val Ile Phe Val Phe Leu Phe Leu Asn 20 25 30 Tyr Thr Leu Ser Leu Met Arg Asn Leu Thr Ile Ile Leu Leu Thr Leu 35 40 45 Leu Asp Pro His Leu Lys Met Pro Met Tyr Phe Phe Leu His Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ile Phe Thr Met Val Cys Ile Pro Arg Tyr Leu 65 70 75 80 Lys Thr Ile Val Thr Lys Glu Lys Asn Ile Ser Tyr Asn Asn Cys Val

85 90 95

Page 966

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Thr Gln Leu Phe 100 Phe Ile Leu Leu Leu Gly Val Ala Glu Phe Tyr Leu 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Pro Ile Ile Met Asn Ser Arg Val Cys Tyr Trp Leu Val Leu 130 135 140 Ser Ser Trp Leu Thr Gly Phe Leu Ile Ile Phe Thr Pro Leu Leu Met 145 150 155 160 Gly Leu Lys Leu Asp Phe Ser Ala Ser Lys Ala Ile Asp His Phe Met 165 170 175 Cys Glu Thr Ser Pro Ile Leu Gln Ile Ser Cys Thr Asp Thr His Val 180 185 190 Leu Glu Leu Met Ser Phe Ile Phe Ala Val Val Thr Leu Val Val Thr 195 200 205 Leu Val Leu Val Val Leu Ser Tyr Thr Cys Ile Met Lys Thr Ile Met 210 215 220 Lys Phe Pro Ser Ala Gln Gln Arg Thr Lys Ala Phe Ser Ala Cys Thr 225 230 235 240 Ser His Met Ile Val Val Ser Met Thr Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Lys Pro Ser Ala Lys Glu Arg Val Thr Val Ser Lys Asp Val 260 265 270 Ala Leu Leu Tyr Thr Ser Ile Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Gln Gln Val Lys Glu Ile Phe Trp Asp Met Leu Gln 290 295 300

Page 967

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Lys Arg Leu Cys Phe Ser Lys Lys Leu Leu 305 310 <210> 859 <211> 939 <212> DNA <213> Canis familiaris <400> 859

atggaaagtg caaaccattc agtggtgtct gaattcattt tgcttggact ttccaaatct 60 cagaatcttc agattttgtt ctttgtagga ttctctgtgg tctatgccgg gattgtgtta 120 ggaaacctcc tcatcttggt cactgtgacc tttgactcac accttcacac accaatgtac 180 tttctgctta tcaatctgtc ctgtatagat atgatcctag cttcttttgc tacccctaag 240 atgatcatag acttcctccg aaaacagaag accatctctt ggtggggatg ttattctcag 300 atgtttttca tgcacctcct aggtgggact gagatgatgt tgcttgtagc catggcaata 360 gacaggtatg ttgccatatg caaacccctc cattacatga ccataatgag cccacgagtg 420 ctcgttgggc tgctgttatc ttcctacgca gttggctttg tgcactcgtc tagtcaaatg 480 gctttcatgt tgcatttgcc cttctgtggt cccagtgtgg tggacagctt tttctgtgac 540 cttccccttg tgatcaaact tgcttgcgag gacacctacc tgctacaact gctggttatt 600 gctgacagcg gcctcctgtc tctgatctgc ttcctcctct tgcttgtctc ctacatggtt 660 atcatatact cagtcaggca ccgtgctgct ggtggttcag ccaaggcctt ctccactctg 720 tcagcacaca tcacagttgt cactctcttc tttgccccat gtgtctttat ctatgtatgg 780 ccctttagca gatattctgt agataaaatt ctttccgtgt tttatacaat tttcacacct 840 ctcttaaatc ctattattta tacattaagg aatcaagaag taaaagcagc cataaagagg 900 ataagaactc gacatataaa ttcaaaacac actttgtag 939

<210> 860 <211> 312 <212> PRT <213> Canis familiaris <400> 860

Met Glu Ser Ala Asn His Ser Val Val Ser Glu Phe Ile Leu Leu Gly Page 968

0 6926 9_02 25_S L.TX T 1 5 10 15 Leu Ser Lys Ser Gln Asn Leu Gln Ile Leu Phe Phe Val Gly Phe Ser 20 25 30 Val Val Tyr Ala Gly Ile Val Leu Gly Asn Leu Leu Ile Leu Val Thr 35 40 45 Val Thr Phe Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Ile 50 55 60 Asn Leu Ser Cys Ile Asp Met Ile Leu Ala Ser Phe Ala Thr Pro Lys 65 70 75 80 Met Ile Ile Asp Phe Leu Arg Lys Gln Lys Thr Ile Ser Trp Trp Gly 85 90 95 Cys Tyr Ser Gln Met Phe Phe Met His Leu Leu Gly Gly Thr Glu Met 100 105 110 Met Leu Leu Val Ala Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Met Thr Ile Met Ser Pro Arg Val Leu Val Gly Leu 130 135 140 Leu Leu Ser Ser Tyr Ala Val Gly Phe Val His Ser Ser Ser Gln Met 145 150 155 160 Ala Phe Met Leu His Leu Pro Phe Cys Gly Pro Ser Val Val Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Glu Asp Thr 180 185 190 Tyr Leu Leu Gln Leu Leu Val Ile Ala Asp Ser Gly Leu Leu Ser Leu 195 200 205 Ile Cys Phe Leu Leu Leu Leu Val Ser Tyr Met Val Ile Ile Tyr Ser

Page 969

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210 215 Ser Ala 220 Lys Ala Phe Ser Thr Leu Val 225 Arg His Arg Ala Ala 230 Gly Gly 235 240 Ser Ala His Ile Thr Val Val Thr Leu Phe Phe Ala Pro Cys Val Phe 245 250 255 Ile Tyr Val Trp Pro Phe Ser Arg Tyr Ser Val Asp Lys Ile Leu Ser 260 265 270 Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Ala Ala Ile Lys Arg Ile Arg Thr Arg 290 295 300 His Ile Asn Ser Lys His Thr Leu 305 310

<210> 861 <211> 948 <212> DNA <213> Canis familiaris <400> 861

atggccatgg aagatgcaaa tctcacgtca gtcactgagt tcctgctcct gggcctttca 60 gagaacccca agcaacagca gctgctgttc ataatcttcc tgactatgta cctggtcacg 120 gggctgggaa acctgctcat catcctggct atcgccactg acccccgact ccacacgccc 180 atgtacttct tcctggctaa cttggccttt gtggacattt gcttcacctc caccaccatt 240 cccaagatgc tagccaacca cgtatcagga cacaaaggga tcccttatgc gggctgcctg 300 acccagatgt tcttcttcat ctggtttgct ggcatcgata gcttcctgct ggctgccatg 360 gcctatgacc gctatgtggc catctgtcac cctctgcact acaccacatc tgtaacgcca 420 cagctctgtg gattcctggt ggctgcatcc tggactgcag ccttcgggaa tgccctaacc 480 cacactgtat tactgactcg cctctcattc tgcacccaca accgggttcc ccatttcttt 540 tgtgacctca gccctctgct gaagttggcc tgctctgaca tctttctcaa taatataatg 600

Page 970

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gtgtacactg tgggcgccct acccatcatc acaccctttg tgggcatctt ggtctcctac 660 atacgcatct ttgccacggt gctaaggatc ccttccacca gaggcaagca gaaagctttc 720 tccacctgtg gctctcatct gtctgtggtg tccctattct acgggacact cattggggtt 780 tatttcagcc caatgtcctc ccacacggcc cagaaggaca cagccgctgc ggtgatgtac 840 accgtggtca ctcccatgct gaaccccttc atctacagcc tacgcaacag tgacatgaag 900 ggggctttgg gggccctcat caataggaag ccagttttta gtcagtga 948

<210> 862 <211> 315 <212> PRT <213> Canis familiaris <400> 862

Met Ala Met Glu Asp Ala Asn Leu Thr Ser Val Thr Glu Phe Leu Leu 1 5 10 15 Leu Gly Leu Ser Glu Asn Pro Lys Gln Gln Gln Leu Leu Phe Ile Ile 20 25 30 Phe Leu Thr Met Tyr Leu Val Thr Gly Leu Gly Asn Leu Leu Ile Ile 35 40 45 Leu Ala Ile Ala Thr Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ala Asn Leu Ala Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile 65 70 75 80 Pro Lys Met Leu Ala Asn His Val Ser Gly His Lys Gly Ile Pro Tyr 85 90 95 Ala Gly Cys Leu Thr Gln Met Phe Phe Phe Ile Trp Phe Ala Gly Ile 100 105 110 Asp Ser Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125

Page 971

Cys His 130 Pro Leu His Tyr Thr 135 069269_0225_SL.TXT Thr Ser Val Thr Pro Gln 140 Leu Cys Gly Phe Leu Val Ala Ala Ser Trp Thr Ala Ala Phe Gly Asn Ala Leu Thr 145 150 155 160 His Thr Val Leu Leu Thr Arg Leu Ser Phe Cys Thr His Asn Arg Val 165 170 175 Pro His Phe Phe Cys Asp Leu Ser Pro Leu Leu Lys Leu Ala Cys Ser 180 185 190 Asp Ile Phe Leu Asn Asn Ile Met Val Tyr Thr Val Gly Ala Leu Pro 195 200 205 Ile Ile Thr Pro Phe Val Gly Ile Leu Val Ser Tyr Ile Arg Ile Phe 210 215 220 Ala Thr Val Leu Arg Ile Pro Ser Thr Arg Gly Lys Gln Lys Ala Phe 225 230 235 240 Ser Thr Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr 245 250 255 Leu Ile Gly Val Tyr Phe Ser Pro Met Ser Ser His Thr Ala Gln Lys 260 265 270 Asp Thr Ala Ala Ala Val Met Tyr Thr Val Val Thr Pro Met Leu Asn 275 280 285 Pro Phe Ile Tyr Ser Leu Arg Asn Ser Asp Met Lys Gly Ala Leu Gly 290 295 300 Ala Leu Ile Asn Arg Lys Pro Val Phe Ser Gln 305 310 315

<210> 863 <211> 930 <212> DNA <213> Canis familiaris

Page 972

069269_0225_SL.TXT <400> 863

atggtgtctg aattcattct cgtgggcttc tccaccttcc cacagcatct cctgcctgtc 60 ttctttctgt tctacttgct gatgtacctg ttcacgctgc tggggaacct gctcatcatg 120 gctactattt ggagtgagcg caacctgcac acgcccatgt acctcttcct gtgtgccctg 180 tccacctctg agattctgtt cactgttgcc gtcacccccc gcatgctggt tgacatgctc 240 tccagccacc gttccatcac ctttgtggcc tgtgccaccc agatgttctt ctccttcacg 300 tttggcttca cccattcctt cttgcttatg atcatgggtt atgaccgcta tgtggccatc 360 tgccaccccc tacgctacaa cgtgctcatg agcatccgca cctgtgcccg tttggtgtcc 420 tggacctggg ctggtggctc agtcatgggg atgatggtga ccctgatagt ttttcacctc 480 accttctgtg ggtctaatgt gattcatcat tttctctgcc atgtgttttc cctcttaaag 540 ttggcttgtg ggaatgagaa ttcctcagtc accttgggtg tgatccttgt gtgtgtctca 600 gctctgatgg gctgtttatt cctcatcatc ctctcctata tcttcatcgt ggcggccata 660 ttgaggatcc cctctgttga gggaaggcac aagaccttct ccacctgtgt gtcccacctc 720 actattgtta ttgtgcacta cagttttgcc tccattatct acctcaagcc gaagggcccc 780 cattctatgg acagtaacac cctgatggcc accacctata cagtctttac cccgtttctc 840 agcccaatca tttttagcct caggaataag gagctcaaga atgccataaa gaaaagcttc 900 cagagaaaat tcagtccctt acgctcctga 930

<210> 864 <211> 309 <212> PRT <213> Canis familiaris <400> 864

Met 1 Val Ser Glu Phe Ile Leu Val Gly Phe Ser Thr Phe Pro Gln His 5 10 15 Leu Leu Pro Val Phe Phe Leu Phe Tyr Leu Leu Met Tyr Leu Phe Thr 20 25 30 Leu Leu Gly Asn Leu Leu Ile Met Ala Thr Ile Trp Ser Glu Arg Asn 35 40 45

Page 973

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Leu His 50 Thr Pro Met Tyr Leu Phe 55 Leu Cys Ala Leu Ser Thr Ser 60 Glu Ile Leu Phe Thr Val Ala Val Thr Pro Arg Met Leu Val Asp Met Leu 65 70 75 80 Ser Ser His Arg Ser Ile Thr Phe Val Ala Cys Ala Thr Gln Met Phe 85 90 95 Phe Ser Phe Thr Phe Gly Phe Thr His Ser Phe Leu Leu Met Ile Met 100 105 110 Gly Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Asn Val 115 120 125 Leu Met Ser Ile Arg Thr Cys Ala Arg Leu Val Ser Trp Thr Trp Ala 130 135 140 Gly Gly Ser Val Met Gly Met Met Val Thr Leu Ile Val Phe His Leu 145 150 155 160 Thr Phe Cys Gly Ser Asn Val Ile His His Phe Leu Cys His Val Phe 165 170 175 Ser Leu Leu Lys Leu Ala Cys Gly Asn Glu Asn Ser Ser Val Thr Leu 180 185 190 Gly Val Ile Leu Val Cys Val Ser Ala Leu Met Gly Cys Leu Phe Leu 195 200 205 Ile Ile Leu Ser Tyr Ile Phe Ile Val Ala Ala Ile Leu Arg Ile Pro 210 215 220 Ser Val Glu Gly Arg His Lys Thr Phe Ser Thr Cys Val Ser His Leu 225 230 235 240 Thr Ile Val Ile Val His Tyr Ser Phe Ala Ser Ile Ile Tyr Leu Lys 245 250 255

Page 974

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Pro Lys Gly Pro His Ser Met Asp Ser Asn Thr Leu Met Ala Thr Thr 260 265 270 Tyr Thr Val Phe Thr Pro Phe Leu Ser Pro Ile Ile Phe Ser Leu Arg 275 280 285 Asn Lys Glu Leu Lys Asn Ala Ile Lys Lys Ser Phe Gln Arg Lys Phe 290 295 300

Ser Pro Leu Arg Ser 305 <210> 865 <211> 468 <212> DNA <213> Canis familiaris <400> 865

tgggctggtg gctcaatcat ggggatgatg gtgaccctga caggttttca cctcaccttc 60 tgttggtcta atgtgatcca ccatttttcc agcttcatgc tttccctcct aaagttggcc 120 tgtgggaagg agacatcatc tgtcaccttg ggagtggccc tggtgtgtgt cacagccgtg 180 atgggctgtt tatgcctcat tgtcctctcc tgtgtcttca tcgtgcccat ggtatttagg 240 actccgtctg ctgagggcag gcataagacc atctccactt gtgtctccca cctcactgtg 300 gtcattgtgc aatatgtttt tgcctccact atctagctcc agcccgtgga cccatttcta 360 tggacagtaa cactctgatg gccaccacct acagtcttca ccccctttct cagcccaatg 420 tttttcagcc ttcaatataa ggagctctag tatgccttaa agaaatca 468

<210> 866 <211> 111 <212> PRT <213> Canis familiaris <400> 866

Trp Ala Gly Gly Ser Ile Met Gly Met Met Val Thr Leu Thr Gly Phe 1 5 10 15

His Leu Thr Phe Cys Trp Ser Asn Val Ile His His Phe Ser Ser Phe 20 25 30

Page 975

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Met Leu Ser 35 Leu Leu Lys Thr Leu 50 Gly Val Ala Leu Cys 65 Leu Ile Val Leu Ser 70 Thr Pro Ser Ala Glu 85 Gly His Leu Thr Val Val Ile

100

Leu Ala 40 Cys Gly Lys Val 55 Cys Val Thr Ala Cys Val Phe Ile Val 75 Arg His Lys Thr 90 Ile Val Gln Tyr 105 Val Phe

Glu Thr 45 Ser Ser Val Val 60 Met Gly Cys Leu Pro Met Val Phe Arg 80 Ser Thr Cys Val 95 Ser Ala Ser Thr 110 Ile

<210> 867 <211> 924 <212> DNA <213> Canis familiaris <400> 867 atggtgtctg aattcatcct ttctttctgt tctacttgct gctactgtct ggagtgagcg tccacctctg agattctgtt tccagccacc actccatcac ttcggcttca cccattcctt tgccaccccc tacgctacaa tggacctggg ctagtggctc accttctgtg ggtctaatat ttggcctgtg ggaaggagac gctctgatgg gctgtttatt ttaaggatcc cctctgctga cgtgggcttc tccaccttcc gatgtacctg ttcacgctgc cagcctgcac acgcccatgt cactgttgcc gtcacccccc ctttgtggcc tgtgccaccc cttgcttatg atcatgggtt cgtgctcatg agcatccgca agtcatgggg atgatggtga gatctaccat tttggctgcc atcctcggtt acattgggtg cctcatcgtc ctctcttatg gggcagaacc aagaccttct cacagcatct cctgcctgcc tggggaacct gctcatcatg acctcttcct gtgtgccctg gcatgctggt tgacatgctc agatgttctt ctccttcatg atgaccgcta cgtggccatc cctgtgcccg tttggtgtcc ccctgatagt ttttcacctc atgtgttttc cctcttaaag tgatcctcgt gtgtgtctca ttttcatcgt ggctgccata ccacgtgtgt ctcccacctc

120

180

240

300

360

420

480

540

600

660

720

Page 976

069269_0225_SL.TXT actgtggtca ttgtgcacta tggttttgcc tccattatct acctcaagcc caggagctct 780 atggacagta acaccctgat ggccaccacc tatacagtct tcaccccatt tctcagccca 840 atcattttca gcctcaggaa taaggagctc aagaatgcca taaagaaaag cttccagaga 900 aaattccgtc ccctaggctc ctga 924 <210> 868 <211> 307 <212> PRT <213> Canis familiaris <400> 868

Met Val Ser Glu Phe Ile Leu Val Gly Phe Ser Thr Phe Pro Gln His 1 5 10 15

Leu Leu Pro Ala Phe Phe Leu Phe Tyr Leu Leu Met Tyr Leu Phe Thr 20 25 30

Leu Leu Gly Asn Leu Leu Ile Met Ala Thr Val Trp Ser Glu Arg Ser 35 40 45

Leu His Thr Pro Met Tyr Leu Phe Leu Cys Ala Leu Ser Thr Ser Glu 50 55 60

Ile Leu Phe Thr Val Ala Val Thr Pro Arg Met Leu Val Asp Met Leu 65 70 75 80

Ser Ser His His Ser Ile Thr Phe Val Ala Cys Ala Thr Gln Met Phe 85 90 95

Phe Ser Phe Met Phe Gly Phe Thr His Ser Phe Leu Leu Met Ile Met 100 105 110

Gly Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Asn Val 115 120 125

Leu Met Ser Ile Arg Thr Cys Ala Arg Leu Val Ser Trp Thr Trp Ala 130 135 140

Ser Gly Ser Val Met Gly Met Met Val Thr Leu Ile Val Phe His Leu

Page 977

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145 150 155 160 Thr Phe Cys Gly Ser Asn Met Ile Tyr His Phe Gly Cys His Val Phe 165 170 175 Ser Leu Leu Lys Leu Ala Cys Gly Lys Glu Thr Ser Ser Val Thr Leu 180 185 190 Gly Val Ile Leu Val Cys Val Ser Ala Leu Met Gly Cys Leu Phe Leu 195 200 205 Ile Val Leu Ser Tyr Val Phe Ile Val Ala Ala Ile Leu Arg Ile Pro 210 215 220 Ser Ala Glu Gly Arg Thr Lys Thr Phe Ser Thr Cys Val Ser His Leu 225 230 235 240 Thr Val Val Ile Val His Tyr Gly Phe Ala Ser Ile Ile Tyr Leu Lys 245 250 255 Pro Arg Ser Ser Met Asp Ser Asn Thr Leu Met Ala Thr Thr Tyr Thr 260 265 270 Val Phe Thr Pro Phe Leu Ser Pro Ile Ile Phe Ser Leu Arg Asn Lys 275 280 285 Glu Leu Lys Asn Ala Ile Lys Lys Ser Phe Gln Arg Lys Phe Arg Pro 290 295 300

Leu Gly Ser 305 <210> 869 <211> 1023 <212> DNA <213> Canis familiaris <400> 869 atgtattcat tccctttctt cctctttttt ttttttttca ttccttttct agtctcagca gatgcagcat ccgtggctgg tcagaactat agcatggtgt ctgaattcat ccttgtgggc Page 978

120

069269_0225_SL.TXT

ttctccacat tctcaaggca tctcctgcct gtcttcttcc tgatttacct gctgatgtac 180 ctgttcacgc tgctggggaa cctgctcatc atggctactg tctggagtga ccacagcctg 240 cacacaccca tgtacctctt cctgtgtgcc ctgtccacct ctgagattct gttcactgtt 300 actgtcaccc ctcgcatgct ggttgacata ctctctagcc accactctat cacctttgtg 360 gcctgtgcca cccagatgtt cttctccttc acatttggct tcacccattc cttcttgcta 420 acgatcatgg gctatgaccg ctacgtggcc atctgccacc ctctgcgcta caacgtgctc 480 atgagcaccg acacctgtgc tcgtctggtg tcttggacct gggctggtgg ctcagtaata 540 gggatgacgg taaccctgtt agtttttcac ctcaccttct gtgggtctaa tgtgatccac 600 cattttgtct gccatgtact ttccctccta aaattggcct gtgggaatga gacatcctct 660 gtaaccttga gtgtgatcct ggtgtgtctc tcagccctga tgggctgctt attcctcatc 720 atcctctcct atgtcttcat catgtccacc atattgagaa tcccctctgc tgagggcagg 780 cacaagacct tctccacgtg tgtctcccac ctcactgtgg tcgttgtgca ctatggtttt 840 gcctccatta tctacctcaa gcccaagagc ctccattcca tggacagtaa caccctgatg 900 gccaccacct atacagtctt caccccgttt ctcagcccaa tcattttcag cctcaggaat 960 aaggagctca agaatgccat aaagaaaagc tttcagagaa aattcagtcc cctaggctct 1020

tga 1023 <210> 870 <211> 340 <212> PRT <213> Canis familiaris <400> 870

Met 1 Tyr Ser Phe Pro Phe Phe Leu Phe Phe Phe Phe Phe Ile Pro Phe 5 10 15 Leu Val Ser Ala Asp Ala Ala Ser Val Ala Gly Gln Asn Tyr Ser Met 20 25 30 Val Ser Glu Phe Ile Leu Val Gly Phe Ser Thr Phe Ser Arg His Leu 35 40 45

Page 979

Leu Pro 50 Val Phe Phe Leu Ile 55 069269_0225_SL.TXT Tyr Leu Leu Met Tyr Leu 60 Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr Val Trp Ser Asp His Ser Leu 65 70 75 80 His Thr Pro Met Tyr Leu Phe Leu Cys Ala Leu Ser Thr Ser Glu Ile 85 90 95 Leu Phe Thr Val Thr Val Thr Pro Arg Met Leu Val Asp Ile Leu Ser 100 105 110 Ser His His Ser Ile Thr Phe Val Ala Cys Ala Thr Gln Met Phe Phe 115 120 125 Ser Phe Thr Phe Gly Phe Thr His Ser Phe Leu Leu Thr Ile Met Gly 130 135 140 Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Asn Val Leu 145 150 155 160 Met Ser Thr Asp Thr Cys Ala Arg Leu Val Ser Trp Thr Trp Ala Gly 165 170 175 Gly Ser Val Ile Gly Met Thr Val Thr Leu Leu Val Phe His Leu Thr 180 185 190 Phe Cys Gly Ser Asn Val Ile His His Phe Val Cys His Val Leu Ser 195 200 205 Leu Leu Lys Leu Ala Cys Gly Asn Glu Thr Ser Ser Val Thr Leu Ser 210 215 220 Val Ile Leu Val Cys Leu Ser Ala Leu Met Gly Cys Leu Phe Leu Ile 225 230 235 240 Ile Leu Ser Tyr Val Phe Ile Met Ser Thr Ile Leu Arg Ile Pro Ser 245 250 255

Page 980

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Ala Glu Gly Arg His 260 Lys Thr Phe Ser Thr Cys Val Ser His Leu Thr 265 270 Val Val Val Val His Tyr Gly Phe Ala Ser Ile Ile Tyr Leu Lys Pro 275 280 285 Lys Ser Leu His Ser Met Asp Ser Asn Thr Leu Met Ala Thr Thr Tyr 290 295 300 Thr Val Phe Thr Pro Phe Leu Ser Pro Ile Ile Phe Ser Leu Arg Asn 305 310 315 320 Lys Glu Leu Lys Asn Ala Ile Lys Lys Ser Phe Gln Arg Lys Phe Ser 325 330 335 Pro Leu Gly Ser 340

<210> 871 <211> 960 <212> DNA <213> Canis familiaris <400> 871

atggctgcca ccttgggcct aaaccacagc tctgtgtctg aattcatcct cgtgggcttc 60 tccaccttcc cgccccatct cttgcctgcc ttcttcctgc tgtttctgct catgtacctg 120 ttcacgctgc tggggaacct gctcatcatg gccactgtct ggagcgagcg cgccctgcac 180 acgcccatgt acctcttcct gtgcaccctg tccatctccg agatcctcta caccttggcc 240 atcaccccgc gcctgctggc tgacctgctc tccacccgcc gcaccatcgc ctttgcagcc 300 tgtaccagcc agatgttctt ctccttcacg ttcggcttca cccactcctt cctgctcacg 360 gtcatgggct acgaccgcta tgtggctatc tgccaccctc tgcgctataa cgtgctcatg 420 agcccccgag gttgtacctg cctggtggcc tggtcctggg ctggtggctc agtcatgggg 480 ctggtggtga ccacagctgt tttccacctc actttctgtg gacccaatga gatccaccat 540 ttcttctgcc acgtgccccc tctcttgaag ctggcctgtg gaactgatgt accaatagtg 600 gccctgggtg tggggctggt gtgcatcact gccctgctgg gctgctttct cctcatcctc 660

Page 981

069269_0225_SL.TXT ctttcctacg ccttcatcgt ggctgccatc ttgaggatcc cctctgctga gggcaggcac aaagccttct ccacctgtgc atcccacctc actgtggtgg tcgtgcacta tggctttgcc tctgtcatct acctcaagcc caaggctccc cagtctctgg aaggagacac tctgatgggc atcacctaca caatccttac acctttcctc agtcccatca tcttcagtct caggaacaag gaactgaaga ccgccatgaa gaagaccttc ctcagcaaac tctatcccca gagctcctga

720

780

840

900

960 <210> 872 <211> 319 <212> PRT <213> Canis familiaris <400> 872

Met Ala Ala 1 Thr Leu Gly Leu Asn 5 His Ser Ser Val Ser Glu Phe Ile 10 15 Leu Val Gly Phe Ser Thr Phe Pro Pro His Leu Leu Pro Ala Phe Phe 20 25 30 Leu Leu Phe Leu Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu 35 40 45 Ile Met Ala Thr Val Trp Ser Glu Arg Ala Leu His Thr Pro Met Tyr 50 55 60 Leu Phe Leu Cys Thr Leu Ser Ile Ser Glu Ile Leu Tyr Thr Leu Ala 65 70 75 80 Ile Thr Pro Arg Leu Leu Ala Asp Leu Leu Ser Thr Arg Arg Thr Ile 85 90 95 Ala Phe Ala Ala Cys Thr Ser Gln Met Phe Phe Ser Phe Thr Phe Gly 100 105 110 Phe Thr His Ser Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly 130 135 140

Page 982

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Cys Thr 145 Cys Leu Val Ala 150 Trp Ser Trp Ala Gly Gly Ser Val Met Gly 155 160 Leu Val Val Thr Thr Ala Val Phe His Leu Thr Phe Cys Gly Pro Asn 165 170 175 Glu Ile His His Phe Phe Cys His Val Pro Pro Leu Leu Lys Leu Ala 180 185 190 Cys Gly Thr Asp Val Pro Ile Val Ala Leu Gly Val Gly Leu Val Cys 195 200 205 Ile Thr Ala Leu Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala 210 215 220 Phe Ile Val Ala Ala Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His 225 230 235 240 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Val Val His 245 250 255 Tyr Gly Phe Ala Ser Val Ile Tyr Leu Lys Pro Lys Ala Pro Gln Ser 260 265 270 Leu Glu Gly Asp Thr Leu Met Gly Ile Thr Tyr Thr Ile Leu Thr Pro 275 280 285 Phe Leu Ser Pro Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Thr 290 295 300 Ala Met Lys Lys Thr Phe Leu Ser Lys Leu Tyr Pro Gln Ser Ser

305 310 315 <210> 873 <211> 948 <212> DNA <213> Canis familiaris <400> 873 atgcagagag gcaatttctc agtggtgact gaattcatcc tcgtgggctt ctccaccttc Page 983

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ccccaccttc agctgatgtt cttcctgctg tttctgctca tgtacctgtt cacgctgctg 120 gggaacctgc tcatcatggc cactgtcggg agcgagcgcg gcctgcacac gcccatgtac 180 ctcttcctgt gcgccctgtc catctccgag atcctctaca ccttggccat caccccgcgc 240 ctgctggccg acctgctctc cacccaccac accatcacct ctatggcctg tgccagccag 300 atgttcttct ctttcacgtt cggcttcacc cactccttcc tgctcacggt catgggctac 360 gaccgctatg tggccatctg ccaccctctg cgctataacg tgctcatgag tccccgaggt 420 tgtacctgcc tggtggtctg gtcctgggtt ggtggcttgg tcatggggct ggtggtgacc 480 acagctgttt tccacctcac tttctgtgga cccaatgaga tccaccattt tgcttgccat 540 gtgccccctc tcttgaagct ggcctgtgga actgatgtac caatagtggc cctgggtgtg 600 gggctggtgt gcatcactgc cctgctgggc tgctttctcc tcatcctcct ttcctacgcc 660 ttcatcgtgg ctgccatctt gaggatcccc tctgctgagg gcaggcacaa agccttctcc 720 acctgtgcat cccacctcac tgtggtggtc gtgcactatg gctttgcctc tgtcatctac 780 ctcaagccca aggctcccca gtctctggaa ggagacactc tgatgggcat cacctacaca 840 atccttacac ctttcctcag tcccatcatc ttcagtctca ggaacaagga actgaagacc 900 gccatgaaga agaccttcct cagcaaattg tatccagaaa aaatatga 948

<210> 874 <211> 315 <212> PRT <213> Canis familiaris <400> 874

Met Gln Arg Gly Asn Phe Ser Val Val Thr Glu Phe Ile Leu Val Gly 1 5 10 15 Phe Ser Thr Phe Pro His Leu Gln Leu Met Phe Phe Leu Leu Phe Leu 20 25 30 Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr 35 40 45 Val Gly Ser Glu Arg Gly Leu His Thr Pro Met Tyr Leu Phe Leu Cys 50 55 60

Page 984

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Ala 65 Leu Ser Ile Ser Glu Ile Leu Tyr Thr Leu Ala Ile Thr Pro Arg 70 75 80 Leu Leu Ala Asp Leu Leu Ser Thr His His Thr Ile Thr Ser Met Ala 85 90 95 Cys Ala Ser Gln Met Phe Phe Ser Phe Thr Phe Gly Phe Thr His Ser 100 105 110 Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly Cys Thr Cys Leu 130 135 140 Val Val Trp Ser Trp Val Gly Gly Leu Val Met Gly Leu Val Val Thr 145 150 155 160 Thr Ala Val Phe His Leu Thr Phe Cys Gly Pro Asn Glu Ile His His 165 170 175 Phe Ala Cys His Val Pro Pro Leu Leu Lys Leu Ala Cys Gly Thr Asp 180 185 190 Val Pro Ile Val Ala Leu Gly Val Gly Leu Val Cys Ile Thr Ala Leu 195 200 205 Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Val Ala 210 215 220 Ala Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Thr Val Val Val Val His Tyr Gly Phe Ala 245 250 255 Ser Val Ile Tyr Leu Lys Pro Lys Ala Pro Gln Ser Leu Glu Gly Asp 260 265 270

Page 985

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Thr Leu Met Gly Ile Thr Tyr Thr Ile Leu Thr Pro Phe Leu Ser Pro 275 280 285 Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Thr Ala Met Lys Lys 290 295 300 Thr Phe Leu Ser Lys Leu Tyr Pro Glu Lys Ile

305 310 315 <210> 875 <211> 936 <212> DNA <213> Canis familiaris <400> 875

atggacaatc agacccggaa ctttgaattt atcctccttg gcctctctga gcagccattg 60 cagcagcagg tgttctttgg tctgtctttc agcctgtatc tgattgggtg catggggaat 120 ctgctcagca ttctggccat cctcttggac cctcacctcc atagccccat gtacttcttc 180 ctcagcaacc tgtctcttct tgacatctgc tttgcctcca ccaccatccc caagatgttg 240 gtgaaccacc tatgtgggca cagcaccatc tcctccaagg cttgcctgac ccagatgtat 300 ttcttcatta cctttggggc agctgacagc atccttcttt ccaccatggc ctatgaccgc 360 tatctagcca tctgttgccc actacgctac atcacaatca tgagtgtcct tcgttgtgcc 420 ttgctggtgg cagtcccctg gatctcagca aacctcatct ccatggtcca tactatcctg 480 atgacccgct tgtccttttg caccaatagg atcccacact ttttctgtga cctcaatgcc 540 ttgatcaagc tctcctgctc taatacccaa gtcaatgaga tgctggtgtt ggtctttggg 600 ggctcagttg ttctgatccc ttttgtgtgc atcatggcct cttatacacc tattgctatg 660 gctgtgtgga aggtgccctc agcacagggg aagtggaaag cattctccac ctgtagctct 720 cacctttgtg ttgttgctct cttctatggg accattattg gggtctactt caaccctgca 780 tccacacaca ccacccagaa ggacatagca accacagtga tgtacaccat ggtcaccccc 840 atgctgaacc ccttcatata tagccttcgg aaccgagatc tgaaggaagc cctctggaaa 900 cttctcaaag gaaaccactt ggctacgcct ctttga 936

Page 986

069269_0225_SL.TXT <210> 876 <211> 311 <212> PRT <213> Canis familiaris <400> 876

Met 1 Asp Asn Gln Thr Arg Asn Phe Glu Phe Ile Leu Leu Gly Leu Ser 5 10 15 Glu Gln Pro Leu Gln Gln Gln Val Phe Phe Gly Leu Ser Phe Ser Leu 20 25 30 Tyr Leu Ile Gly Cys Met Gly Asn Leu Leu Ser Ile Leu Ala Ile Leu 35 40 45 Leu Asp Pro His Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Leu Asp Ile Cys Phe Ala Ser Thr Thr Ile Pro Lys Met Leu 65 70 75 80 Val Asn His Leu Cys Gly His Ser Thr Ile Ser Ser Lys Ala Cys Leu 85 90 95 Thr Gln Met Tyr Phe Phe Ile Thr Phe Gly Ala Ala Asp Ser Ile Leu 100 105 110 Leu Ser Thr Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Cys Pro Leu 115 120 125 Arg Tyr Ile Thr Ile Met Ser Val Leu Arg Cys Ala Leu Leu Val Ala 130 135 140 Val Pro Trp Ile Ser Ala Asn Leu Ile Ser Met Val His Thr Ile Leu 145 150 155 160 Met Thr Arg Leu Ser Phe Cys Thr Asn Arg Ile Pro His Phe Phe Cys 165 170 175 Asp Leu Asn Ala Leu Ile Lys Leu Ser Cys Ser Asn Thr Gln Val Asn

Page 987

180

069269_0225_SL.TXT 185 190

Glu Met Leu 195 Val Leu Val Phe Gly Gly Ser Val Val Leu Ile Pro Phe 200 205 Val Cys Ile Met Ala Ser Tyr Thr Pro Ile Ala Met Ala Val Trp Lys 210 215 220 Val Pro Ser Ala Gln Gly Lys Trp Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Leu Cys Val Val Ala Leu Phe Tyr Gly Thr Ile Ile Gly Val Tyr 245 250 255 Phe Asn Pro Ala Ser Thr His Thr Thr Gln Lys Asp Ile Ala Thr Thr 260 265 270 Val Met Tyr Thr Met Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser 275 280 285 Leu Arg Asn Arg Asp Leu Lys Glu Ala Leu Trp Lys Leu Leu Lys Gly 290 295 300 Asn His Leu Ala Thr Pro Leu

305 310 <210> 877 <211> 957 <212> DNA <213> Canis familiaris <400> 877

atgttcatgg aaccaaaaaa ccaaaaaaac caaacagtag tctcagaatt cctccttctg 60 ggactcacag aaaaaccaga gcatcagact ctcctctttg gacttttcct ctctgtgtac 120 ctggtcaccg tctttgggaa cctgctcatc gtcctggcca tcatcacaga ctcccacctc 180 cacactccca tgtacttctt cctctccaac ctgtccctcg tcgatacctt cttctcttcc 240 accactgtgc ccaagatgct ggtgaatctt tggacccaga accgggctat atcttttgtg 300 ggctgccttg ctcagatgta cagcttccac ctgttcggga ccacggatag cttcctcctg 360

Page 988

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gctgtgatgg ccattgaccg gtttgtggcc attgtccacc ctctacgcta ctcagtcatc 420 atgagccctt gtgtctgtgg gttgctggtg ggggtgccat ggctgatcac caatctccag 480 tcactcgtgc acacctgcct catggctcaa ctgaccttct gtgctggctc tgaaatccct 540 catttcttct gtgatctcat gcccttgttg aagctctcct gctctgacac gcacaccaat 600 gagctggtga tttttgcttt tggaatcatc atgggcatca gtcctctctc atgcatcctc 660 ctctcttaca cctgcatttt ctgggcagtc ttcaagatcc cttctgctca gggcaagtgg 720 aaagctttct ccacttgtgg ctcacacctc actgtggtgt cactgttcta tggcaccatc 780 tttgctgtgt acttgcagcc cacatcacct gcctcctccc agaaggacaa gtcagctgcc 840 ctgatgtgtg gggtggtcat ccccatgttg aaccccttta tatacagcct aaggaacaag 900 gacatgaagg cagccctgaa gaagcttgtc ggcaaagcag tctcctctca gtcctag 957

<210> 878 <211> 318 <212> PRT <213> Canis familiaris <400> 878

Met 1 Phe Met Glu Pro 5 Lys Asn Gln Lys Asn Gln Thr Val Val Ser Glu 10 15 Phe Leu Leu Leu Gly Leu Thr Glu Lys Pro Glu His Gln Thr Leu Leu 20 25 30 Phe Gly Leu Phe Leu Ser Val Tyr Leu Val Thr Val Phe Gly Asn Leu 35 40 45 Leu Ile Val Leu Ala Ile Ile Thr Asp Ser His Leu His Thr Pro Met 50 55 60 Tyr Phe Phe Leu Ser Asn Leu Ser Leu Val Asp Thr Phe Phe Ser Ser 65 70 75 80 Thr Thr Val Pro Lys Met Leu Val Asn Leu Trp Thr Gln Asn Arg Ala 85 90 95

Page 989

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Ile Ser Phe Val Gly 100 Cys Leu Ala Gln Met Tyr Ser Phe His Leu Phe 105 110 Gly Thr Thr Asp Ser Phe Leu Leu Ala Val Met Ala Ile Asp Arg Phe 115 120 125 Val Ala Ile Val His Pro Leu Arg Tyr Ser Val Ile Met Ser Pro Cys 130 135 140 Val Cys Gly Leu Leu Val Gly Val Pro Trp Leu Ile Thr Asn Leu Gln 145 150 155 160 Ser Leu Val His Thr Cys Leu Met Ala Gln Leu Thr Phe Cys Ala Gly 165 170 175 Ser Glu Ile Pro His Phe Phe Cys Asp Leu Met Pro Leu Leu Lys Leu 180 185 190 Ser Cys Ser Asp Thr His Thr Asn Glu Leu Val Ile Phe Ala Phe Gly 195 200 205 Ile Ile Met Gly Ile Ser Pro Leu Ser Cys Ile Leu Leu Ser Tyr Thr 210 215 220 Cys Ile Phe Trp Ala Val Phe Lys Ile Pro Ser Ala Gln Gly Lys Trp 225 230 235 240 Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ser Leu Phe 245 250 255 Tyr Gly Thr Ile Phe Ala Val Tyr Leu Gln Pro Thr Ser Pro Ala Ser 260 265 270 Ser Gln Lys Asp Lys Ser Ala Ala Leu Met Cys Gly Val Val Ile Pro 275 280 285 Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Ala 290 295 300

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069269_0225_SL.TXT

Ala Leu Lys Lys Leu Val Gly Lys Ala Val Ser Ser Gln Ser 305 310 315 <210> 879 <211> 990 <212> DNA <213> Canis familiaris <400> 879

atggaaagag gaaaccaaac aggagttgga aactttctcc tcctgggatt cacagaggaa 60 ctggacctac agcctttctt ctttgggttg ttcctgtcca tgtatctggt cacattcact 120 gggaatctgc tcatcatcct ggccatctgc ttagactccc atctccacac acccatgtat 180 ttcttccttg ccaacctgtc ctctgctgac atctgtttca cctctaccac cgtccctaag 240 atgctgctga acatccagac tcagagcaaa accataacat atgaaggatg cctcagccag 300 attttttttt tcattgtatt tggatgcctg gacaatttac tcctgaccgt aatggcctat 360 gaccgctttg tggctatctg tcaccccctg cattacacag tcatcatgaa cccccagctc 420 tgtgaactgc tcgtcttggg gtcctggtgc atcagtgtaa caggctccct tcttgagacc 480 ttgacccttt tgaggctgtc cttctgcaca aacatggaaa tcccacactt tttttgtgat 540 cttcctgaag tcctgaagct cgcctgttct gacatcctca tcaataacat agtggtgtat 600 tttgtgacta ttgtcctagg tgtttttcct ctctctggaa ccctcttttc ttattctgag 660 attttttcct ccatcctgag aatttcatca gccaggggca aatataaagc cttttccacg 720 tgtgggtctc acctcttggt ggtctccctg ttctatggca caggccttgg ggtctacctc 780 agttctgcag tgacttcatt ctctaagatg agtttgatgg cctcggtgat gtacaccatt 840 gtcaccccta tgctgaaccc cttcatctac agcttgaaga acagggacat gaagggggcc 900 ctgggcaggc tcctcagcag ggtagtacct gtcagcatca ggactctcat gagtagctgg 960 ggacacaata atgaagatga gaaatcttag 990

<210> 880 <211> 329 <212> PRT <213> Canis familiaris <400> 880

Met Glu Arg Gly Asn Gln Thr Gly Val Gly Asn Phe Leu Leu Leu Gly Page 991

0 6926 9_02 25_S L.TX T 1 5 10 15 Phe Thr Glu Glu Leu Asp Leu Gln Pro Phe Phe Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Phe Thr Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Cys Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Ser Ala Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Thr Ile Thr Tyr Glu Gly 85 90 95 Cys Leu Ser Gln Ile Phe Phe Phe Ile Val Phe Gly Cys Leu Asp Asn 100 105 110 Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Gln Leu Cys Glu Leu Leu 130 135 140 Val Leu Gly Ser Trp Cys Ile Ser Val Thr Gly Ser Leu Leu Glu Thr 145 150 155 160 Leu Thr Leu Leu Arg Leu Ser Phe Cys Thr Asn Met Glu Ile Pro His 165 170 175 Phe Phe Cys Asp Leu Pro Glu Val Leu Lys Leu Ala Cys Ser Asp Ile 180 185 190 Leu Ile Asn Asn Ile Val Val Tyr Phe Val Thr Ile Val Leu Gly Val 195 200 205 Phe Pro Leu Ser Gly Thr Leu Phe Ser Tyr Ser Glu Ile Phe Ser Ser

Page 992

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210 215 220 Ile Leu Arg Ile Ser Ser Ala Arg Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Leu Val Val Ser Leu Phe Tyr Gly Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Val Thr Ser Phe Ser Lys Met Ser Leu 260 265 270 Met Ala Ser Val Met Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Lys Asn Arg Asp Met Lys Gly Ala Leu Gly Arg Leu 290 295 300 Leu Ser Arg Val Val Pro Val Ser Ile Arg Thr Leu Met Ser Ser Trp 305 310 315 320 Gly His Asn Asn Glu Asp Glu Lys Ser

325 <210> 881 <211> 939 <212> DNA <213> Canis familiaris <400> 881

atggaattga gaaaccactc agggcttcca gtgtttctcc tcctgggatt ttctgagaag 60 ccagaaattc agtctgttct ctttgggctg ttcctgtctt tgtacctggt cactgtcttt 120 gggaacctgc tcatcatcct ggccatcagc tcagactccc acctccacac ccctatgtac 180 ttcttcctct ccaacctgtc cttttcagat atctgtttca cctcaaccac catcccaaaa 240 atgttgctga gcatccagac tcagaacaaa gtcattacct atgcaggctg catcacacag 300 atgtattttt tcacagtttt tggacttttg gacaatttac ttctgactgc aatggcctat 360 gaccgttttg tggctgtctg tcatcccctg cactacacag tcatcatgaa tcctcagctc 420 tgcgcccagt tactcaccct gacctggctc atcagtgttc tgggggccct tcctgagagt 480

Page 993

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ttaaccatgt tgcgactctc cttctgtgca gtcgttgaaa tcccacacta tttctgtgaa 540 ctccctgaag tcctaaagct tgcctgctct aataccttca ccaataatgt cgtattatat 600 attgtgacag gcgttatggg cttttttcct ctcgctggga tccttttctc ttattctcga 660 attgtctctt ctgtattgaa tatctcaaca gtgggaggaa agtataaagc attctccacc 720 tgtgggtctc acctctccgt ggtctcctta ttctacggaa cctgtctggg ggtctacctc 780 agttccacct ggacacatgc ctctgagaca gggatgttcg cctcagtcct gtataccgtg 840 gtcactccca tgatgaaccc cttcatctac agcctgagga acagagacat gaagagggct 900 ctgagaaagc ttctctgtag catgtcatcc tcccaatga 939

<210> 882 <211> 312 <212> PRT <213> Canis familiaris <400> 882

Met Glu Leu Arg Asn His Ser Gly Leu Pro Val Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Glu Lys Pro Glu Ile Gln Ser Val Leu Phe Gly Leu Phe Leu 20 25 30 Ser Leu Tyr Leu Val Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ser Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Leu Ser Ile Gln Thr Gln Asn Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Thr Val Phe Gly Leu Leu Asp Asn 100 105 110

Page 994

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Leu Leu Leu 115 Thr Ala Met Ala Tyr Asp Arg Phe Val Ala Val Cys His 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Gln Leu Cys Ala Gln Leu 130 135 140 Leu Thr Leu Thr Trp Leu Ile Ser Val Leu Gly Ala Leu Pro Glu Ser 145 150 155 160 Leu Thr Met Leu Arg Leu Ser Phe Cys Ala Val Val Glu Ile Pro His 165 170 175 Tyr Phe Cys Glu Leu Pro Glu Val Leu Lys Leu Ala Cys Ser Asn Thr 180 185 190 Phe Thr Asn Asn Val Val Leu Tyr Ile Val Thr Gly Val Met Gly Phe 195 200 205 Phe Pro Leu Ala Gly Ile Leu Phe Ser Tyr Ser Arg Ile Val Ser Ser 210 215 220 Val Leu Asn Ile Ser Thr Val Gly Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Cys Leu 245 250 255 Gly Val Tyr Leu Ser Ser Thr Trp Thr His Ala Ser Glu Thr Gly Met 260 265 270 Phe Ala Ser Val Leu Tyr Thr Val Val Thr Pro Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Arg Ala Leu Arg Lys Leu 290 295 300 Leu Cys Ser Met Ser Ser Ser Gln

305 310

Page 995

069269_0225_SL.TXT <210> 883 <211> 930 <212> DNA <213> Canis familiaris <400> 883

atggaaccaa agaatgatac acgaatttca gaatttcttc ttctgggatt ttcagaggaa 60 ccagaattgc aacccttcct ctttgggttt ttcctgtgca tgtacctggt caccatactt 120 gggaatctgc tcatcatcct ggctgtcagc tctgattccc acctccacac acccatgtat 180 ttcttccttg ccaacctttc ctttgtagaa atctgtttca tctccaccac tgtccccaag 240 atgctgatga atatacacgc aaagaaaaaa gtcataacat ataaaagctg catcatgcag 300 atgtactttt tcctactttt tgtaggtttg gacaacttcc ttctgactgt gatggcctat 360 gacagattca tggccatctg taatcccctg cactacatgg ttatcatgaa ccctgggctc 420 tgtggactgc tggttctggt gtcctgggtc gtgagtgtct tgcattccct gttacaaacc 480 ttaatggtgt tgcggctgtc cttctgtaca gaggtggaaa tcccccactt tttctgtgaa 540 ctcaatcagg tgatccaact tgcctgttct gacacctttc tcaacaacat ggtgatgtat 600 cttgcaactg tgcttctggc tggtggtccc ctggctgggg tcctttactc ttactctaag 660 atcgtttcct ccatacgtaa aatacaatca gctaagggca agtataaagc attttccacc 720 tgtgcatctc acctctcggt tgtctcctta ttttactgta cgggcctagg agtgtacctt 780 agctctgctg ctacccagag ctcccactca agtgcagaag cctcggtaat gtacacggtt 840 gtcacgccca tgctgaaccc cttcatctac agcctgcgga acagagacat aaagagggtt 900 ctaaatgtat ttttcagaag gaagccataa 930

<210> 884 <211> 309 <212> PRT <213> Canis familiaris <400> 884

Met Glu Pro Lys Asn Asp Thr Arg Ile Ser Glu Phe Leu Leu Leu Gly

1 5 10 15

Phe Ser Glu Glu Pro Glu Leu Gln Pro Phe Leu Phe Gly Phe Phe Leu

20 25 30

Page 996

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Cys Met Tyr 35 Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Ile Leu Ala 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Glu Ile Cys Phe Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Met Asn Ile His Ala Lys Lys Lys Val Ile Thr Tyr Lys Ser 85 90 95 Cys Ile Met Gln Met Tyr Phe Phe Leu Leu Phe Val Gly Leu Asp Asn 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Met Ala Ile Cys Asn 115 120 125 Pro Leu His Tyr Met Val Ile Met Asn Pro Gly Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Val Val Ser Val Leu His Ser Leu Leu Gln Thr 145 150 155 160 Leu Met Val Leu Arg Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Val Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Met Val Met Tyr Leu Ala Thr Val Leu Leu Ala Gly 195 200 205 Gly Pro Leu Ala Gly Val Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Lys Ile Gln Ser Ala Lys Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240

Page 997

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Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Glu Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Val Leu Asn Val Phe 290 295 300 Phe Arg Arg Lys Pro

305 <210> 885 <211> 969 <212> DNA <213> Canis familiaris <400> 885

atggacccag gaaattatac aggaatttca gaattctacc ttatgggatt ttcagaagaa 60 ctagaactac agccccttgt atttgggctt ttcctctcca tgtacctggt cactgtgttt 120 ggaaacctgc tcatcatcct ggccgtcagc tctgaccccc acctccacac ccctatgtac 180 ttcttcctca ccaacctgtc ctttgtagac atctgtttca cctccaccac cgttcccaag 240 atgctgcaga acatccagac ccaaagcaaa gtcatcacct atgcaaggtg cctcacacag 300 atgtactttt tcatactgtt tacaggatta gacatctttc ttctaactgt gatggcttat 360 gaccggtttg tagccatctg tcaccccctg cgctacacgg tgatcatgaa cccctggctt 420 tgtgcactgc tggttctggt gtcctgggtc gtgagtgtcc tgtattcctt gttacaaacc 480 tccatggtgt tgcagctctc cttctgtaca gaggtggaaa tcccccactt tttctgtgaa 540 ctgaatcaga tgatacaact tgcctgctct gacacctttc tcaacaacat ggtgatgtat 600 cttgcaactg tgcttctggc tggtggtccc ttctttggga tcctttactc ttactctcag 660 attgtttcct ccatacatag aatctcatca gctcagggca agtataaagc attttccacc 720 tgtgcatctc acctctcggt tgtctcctta ttttactgta cgggcctagg agtgtacctt 780

Page 998

069269_0225_SL.TXT agctctgctg ctacccagag ctcccactca agtgcagtgg cctcagtgat atacacagtg gtcacgccca tgctgaatcc cttcatctac agcctgcgga acagagacat aaaggaggct ctgatgagat tctctgggat gccagctcta aagggaccaa tcgtcctggg gctgaagaag tgcccatga

840

900

960

969 <210> 886 <211> 322 <212> PRT <213> Canis familiaris <400> 886

Met Asp 1 Pro Gly Asn Tyr Thr Gly Ile Ser Glu Phe Tyr Leu Met 15 Gly 5 10 Phe Ser Glu Glu Leu Glu Leu Gln Pro Leu Val Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Gln Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Arg 85 90 95 Cys Leu Thr Gln Met Tyr Phe Phe Ile Leu Phe Thr Gly Leu Asp Ile 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Pro Trp Leu Cys Ala Leu Leu 130 135 140

Page 999

Val 145 Leu Val Ser Trp Val 150 Val 069269_0225_SL.TXT Ser Val Leu Tyr Ser Leu 155 Leu Gln Thr 160 Ser Met Val Leu Gln Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Met Val Met Tyr Leu Ala Thr Val Leu Leu Ala Gly 195 200 205 Gly Pro Phe Phe Gly Ile Leu Tyr Ser Tyr Ser Gln Ile Val Ser Ser 210 215 220 Ile His Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Val Ala Ser Val Ile Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Glu Ala Leu Met Arg Phe 290 295 300 Ser Gly Met Pro Ala Leu Lys Gly Pro Ile Val Leu Gly Leu Lys Lys 305 310 315 320

Cys Pro <210> 887 <211> 969 <212> DNA <213> Canis familiaris

Page 1000

069269_0225_SL.TXT <400> 887 atggacccaa gaaatgatac aggaatttca gaattctacc ttatgggatt ttcagaggaa 60 ctagaactac agccccttgt atttgggctt ttcctctcca tgtacctgat cactgtgttt 120 ggaaacctgc tcatcatcct ggccgtcagt tctgaccccc acctccacac ccccatgtac 180 ttcttcctca ccaacctgtc ctttgtagac atctgtttca cctccaccac cgttcccaag 240 atgctgcaga acatccagac ccaaagcaaa gtcatcacct atgcaaggtg cctcacacag 300 atgtactttt ttatactgtt tacaggatta gacatctttc ttctaactgt gatggcttat 360 gaccggtttg tagccatctg tcaccccctg cgctacacgg tgatcatgaa cccctggctt 420 tgtgcactgc tggtcctagt gtcctgggtc ctgagtgtcc tgcattcctt gttacaaacc 480 tccatggtgt tgcagctctc cttctgtaca gaggtggaaa tcccccactt tttctgtgaa 540 ctgaatcaga tgatacaact tgcctgctct gacacctttc tcaacaacat ggtaatgtat 600 tttgcagcta tgttgctggc tggtggtacc ttccttggga tcctttactc ttactctagg 660 attgtttcct ccatacatag aatctcatca gctcagggca agtataaagc attttccacc 720 tgtgcatctc acctctcggt tgtctcctta ttttactgta cgggcctagg agtatacctt 780 agctctgctg ctacacagag ttctcactca agtgcagtgg cctcagtgat gtacacagtg 840 gtcataccca tgctgaatcc cttcatctac agcctgcgga acagagacat aaaggaggct 900 ctgatgagat tctctgggat gccagctcta aaagagccaa tcatcctggg gctgaagagg 960 tgcccatga 969 <210> 888 <211> 322 <212> PRT <213> Canis familiaris <400> 888

Met Asp Pro Arg Asn Asp Thr Gly Ile Ser Glu Phe Tyr Leu Met Gly 1 5 10 15 Phe Ser Glu Glu Leu Glu Leu Gln Pro Leu Val Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala Page 1001

069269_0225_SL.TXT 40 45

Val Ser 50 Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Thr 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Gln Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Arg 85 90 95 Cys Leu Thr Gln Met Tyr Phe Phe Ile Leu Phe Thr Gly Leu Asp Ile 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Pro Trp Leu Cys Ala Leu Leu 130 135 140 Val Leu Val Ser Trp Val Leu Ser Val Leu His Ser Leu Leu Gln Thr 145 150 155 160 Ser Met Val Leu Gln Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Met Val Met Tyr Phe Ala Ala Met Leu Leu Ala Gly 195 200 205 Gly Thr Phe Leu Gly Ile Leu Tyr Ser Tyr Ser Arg Ile Val Ser Ser 210 215 220 Ile His Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Gly Leu

Page 1002

245 069269_0225_SL.TXT 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Ile Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Glu Ala Leu Met Arg Phe 290 295 300 Ser Gly Met Pro Ala Leu Lys Glu Pro Ile Ile Leu Gly Leu Lys Arg 305 310 315 320

Cys Pro <210> 889 <211> 234 <212> DNA <213> Canis familiaris <400> 889 cccacttttt cctgtgaact caatcagatg atccaacttg cttgttctga tacctttctt aatgacacag tgctatatgt ttcaactatg ttgctggctg gtggtcccct tgctgggatc ctttattcaa actctaagat tatctcctcc atacttagaa tcttatcagc tcagggcaag tataaagcat tttccacctc tgcatctcac ctctcaggtg tcctcttctt tttt

120

180

234 <210> 890 <211> 78 <212> PRT <213> Canis familiaris <400> 890

Pro Thr Phe Ser Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser 1 5 10 15

Asp Thr Phe Leu Asn Asp Thr Val Leu Tyr Val Ser Thr Met Leu Leu 20 25 30

Page 1003

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Ala Gly Gly Pro Leu Ala Gly Ile 35 40 Ser Ser Ile Leu Arg Ile Leu Ser 50 55 Ser Thr Ser Ala Ser His Leu Ser 65 70

Leu Tyr Ser Asn Ser 45 Lys Ile Ile Ala Gln Gly Lys 60 Tyr Lys Ala Phe Gly Val Leu 75 Phe Phe Phe

<210> 891 <211> 399 <212> DNA <213> Canis familiaris <400> 891 atgggatcag gcaataccca aatttcagga tttcttcttc tgggattatc aaacaaacca 60 gaactgcatc ccctcatatt tgggcttttc ctctccatgt acctgatcac tgtgattgga 120 aattggctca tcatcctggc tgtcagctct gacccccacc tccacacccc cctcaccaac 180 ctgtcctttg tagacatctg tatcacctcc accactatcc ccaagatgtt ccataacatt 240 cagactagga ttaaagtcat aacctatgaa ggctgcatca cacagatata ctttttccta 300 ctctttgctg gactgggtta ctttctcctg tccgaaatgg cctatgacca ctacgtggcc 360 atctgccacc ccctgcacta catggtcatc acaaacccc 399 <210> 892 <211> 133 <212> PRT <213> Canis familiaris <400> 892

Met 1 Gly Ser Gly Asn Thr Gln Ile Ser Gly Phe Leu Leu Leu Gly Leu 5 10 15 Ser Asn Lys Pro Glu Leu His Pro Leu Ile Phe Gly Leu Phe Leu Ser 20 25 30 Met Tyr Leu Ile Thr Val Ile Gly Asn Trp Leu Ile Ile Leu Ala Val 35 40 45

Ser Ser Asp Pro His

Leu His

Thr Pro Leu Thr Asn Page 1004

Leu Ser Phe Val

50 55 069269_0225_SL.TXT 60 Asp Ile Cys Ile Thr Ser Thr Thr Ile Pro Lys Met Phe His Asn Ile 65 70 75 80 Gln Thr Arg Ile Lys Val Ile Thr Tyr Glu Gly Cys Ile Thr Gln Ile 85 90 95 Tyr Phe Phe Leu Leu Phe Ala Gly Leu Gly Tyr Phe Leu Leu Ser Glu 100 105 110 Met Ala Tyr Asp His Tyr Val Ala Ile Cys His Pro Leu His Tyr Met 115 120 125 Val Ile Thr Asn Pro

130 <210> 893 <211> 933 <212> DNA <213> Canis familiaris <400> 893 atggaaccag gaaatgatac acgaatttca gagtttcttc ttctgggatt aacagaggaa ccagaattgc aaaccctcat atttgggctt ttcctcacca tgtacctgat cactgtgttt ggaaatctac tcatcatcct ggccattggc tctgactccc acctccacac ccccatgtac ttctttcttg acaacctgtc ctttgtagac atctgtttca cctccaccac catccccaag atgctgctga atatccagac tcagagcaaa gtgatcactt atgaaggctg catctcacag atttattttc tcatactctt tgccgtgtca gacatctttc ttctgagtgt gatggcctat gaccggtatg tggccatctg ccacccccta cactacatgg tcatcatgaa ccctcatctc tgtaaactgc tagttctggt gtcctggatc atgtctatcc tgaattcctt gttacatagt ttaatgatgt tgcggctgtc cttctgtaca cacttccaaa tcccccactt tttttgtgaa ctcaaccaga tgatccaact tgcctgttct gacacctttc ttaataactt ggtgatgtat tttgcagctg tcctgctggc tggtggtcct ttcgctggga tcctttactc ttactctaag attgtttcct ccatacacag aatctcatca gctcagggca agtataaagc attttctacc Page 1005

120

180

240

300

360

420

480

540

600

660

720

069269_0225_SL.TXT tgtgcatctc acctctcagt tgtctcctta ttttattgta cgatgcttgg tgtgtacctt agctctgctg ctacccagag ctcccacaca agtgcagtgg tctctgtaat gtacactttg gttgcaccca tgctgaaccc cttcatctac agcctgagga acaaagacat aaagagggct ctgaaaagaa tcattggggt tccagagatg taa

780

840

900

933 <210> 894 <211> 310 <212> PRT <213> Canis familiaris <400> 894

Met Glu 1 Pro Gly Asn 5 Asp Thr Arg Ile Ser Glu Phe Leu Leu Leu Gly 10 15 Leu Thr Glu Glu Pro Glu Leu Gln Thr Leu Ile Phe Gly Leu Phe Leu 20 25 30 Thr Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Gly Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Asp 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Gly 85 90 95 Cys Ile Ser Gln Ile Tyr Phe Leu Ile Leu Phe Ala Val Ser Asp Ile 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Met Val Ile Met Asn Pro His Leu Cys Lys Leu Leu 130 135 140

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Val Leu Val Ser Trp Ile Met Ser Ile Leu Asn Ser Leu Leu His Ser 145 150 155 160 Leu Met Met Leu Arg Leu Ser Phe Cys Thr His Phe Gln Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Leu Val Met Tyr Phe Ala Ala Val Leu Leu Ala Gly 195 200 205 Gly Pro Phe Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile His Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Met Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Thr Ser Ala 260 265 270 Val Val Ser Val Met Tyr Thr Leu Val Ala Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Arg Ala Leu Lys Arg Ile 290 295 300 Ile Gly Val Pro Glu Met 305 310

<210> 895 <211> 975 <212> DNA <213> Canis familiaris <400> 895 gaaccaggaa atgttacacg aatttcagag tttcttcttc tgggattatc cgaggaacca

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gaactgcagc ccctcatatt tgggtttttc ctctccatgt acctgatcac tgtgtctgga 120 aatctgctca tcattgtggc cggcagctct gactcccacc tccacacccc catgtacttc 180 ttccttgcca acctgtcctt tgtagacatg gtttcacctc caccgccgtc cccaagatgc 240 tgtggaacat ccagactcag aacaaaatca ttaactatgc aggctgcatc agccagatgt 300 atttttttcc tactatgtgc agagttggac gactttatcc tgtccacaat agcctaagac 360 cacttcatgg ccatctgtca ccccctgcac tacatggtta tcatgaaccc ctggctctgt 420 ggactgctgg ttctagtgtc ctggatcatc ggtgtcctga attccttatt acagagctta 480 atggtgttgt gggtgtcctt ctgtacaggc acggaaatcc ctcatttttt aactcaatca 540 agtaatcagg aatactgttc tgacattttt cttaatgaca tggtgatgta ttttatgact 600 gtgctgctgg caggtggtcc tttcactggg ttcctttact cttactctaa gattgtttcc 660 cccatacata gaatctcatc agcttagagc aagtataaag cattttctac ctgtgcatct 720 cttggttgtc tccttatttt actctaaagc ctagaagtgt actttagctc tgctgctccc 780 cagagctccc acgcaagtgc agtggcctcg gtgatgtaca catagtcata cccatgctga 840 acccctatag tcatacccat gctgaacccc ttcatctata gtctgaagaa cagagacata 900 aagagggctc tgaaaagaat cttcggggtt ccagtgatgc agtggccagt catcctgggg 960 ctgaagatgt gccca 975

<210> 896 <211> 118 <212> PRT <213> Canis familiaris <400> 896

Glu Pro Gly Asn Val Thr Arg Ile Ser Glu Phe Leu Leu Leu Gly Leu 1 5 10 15 Ser Glu Glu Pro Glu Leu Gln Pro Leu Ile Phe Gly Phe Phe Leu Ser 20 25 30 Met Tyr Leu Ile Thr Val Ser Gly Asn Leu Leu Ile Ile Val Ala Gly 35 40 45 Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Page 1008

50 55 069269_0225_SL.TXT 60 Leu Ser Phe Val Asp Met Val Ser Pro Pro Pro Pro Ser Pro Arg Cys 65 70 75 80 Cys Gly Thr Ser Arg Leu Arg Thr Lys Ser Leu Thr Met Gln Ala Ala 85 90 95 Ser Ala Arg Cys Ile Phe Phe Leu Leu Cys Ala Glu Leu Asp Asp Phe 100 105 110 Ile Leu Ser Thr Ile Ala

115 <210> 897 <211> 954 <212> DNA <213> Canis familiaris <400> 897 atggagccag gaaaccttac aggagtttca gagtttcttc ttctggggtt ttcagaagga ccagaactgc agcccttcat atttgggctt ttcctctcca tgtacctgat cactgtgttt ggaaacctgc tcctcatcct ggctgtcagc tctgactccc acctccatac acccatgtac tttttcctcg ccaacctgtc ctttgtagac atctgtttca cctccaccac tgtccccaag atgctgataa acatccagac tcagagcaaa gtgatcactt atgaaggatg cctcagccag atgtattttt tcatactctt tgcaggatta gacatctttc tcctgactgt gatggcttat gaccgctttg tagccatctg ccaccccctg cactacttgg tcatcatgaa ccctcgggta tgtggactgc tggttctggt gccctggatc atgagcatct tgaattcctt gttagaaagc ataatggtgt tgcgcttgtc cttctgtaca gtcttggaaa tcccccactt tttctgtgaa ctcaatcaga tgatacaact tgcatgttct gacacctttc tcagtaacat ggtgatgtat tttgcagctg tgcttctggg tggtgttcct tttgctggaa tcctttactc ttattccaag atagtttcct ctatacgtgg gatctcatca gctcagggaa agtataaagc attttccacc tgtgcatctc acctctcagt tgtctcctta ttttattgta cagtcctggg agtgtacctt agctctgctg ctccccagag ctccaactca agtgcggtgg cctcagtgat gtacacggtg Page 1009

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069269_0225_SL.TXT gtcacaccca tgctgaaccc cttcatctac agcctgagga acagagacat taagaggact cttatgagat tttctagaat gtcagctcta aaatggccaa ctgttctggg ctga

900

954 <210> 898 <211> 317 <212> PRT <213> Canis familiaris <400> 898

Met Glu 1 Pro Gly Asn Leu Thr Gly Val Ser Glu Phe Leu Leu Leu Gly 5 10 15 Phe Ser Glu Gly Pro Glu Leu Gln Pro Phe Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Leu Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Ile Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Gly 85 90 95 Cys Leu Ser Gln Met Tyr Phe Phe Ile Leu Phe Ala Gly Leu Asp Ile 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Leu Val Ile Met Asn Pro Arg Val Cys Gly Leu Leu 130 135 140 Val Leu Val Pro Trp Ile Met Ser Ile Leu Asn Ser Leu Leu Glu Ser 145 150 155 160

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Ile Met Val Leu Arg Leu Ser Phe Cys Thr 170 Val Leu Glu Ile Pro His 175 165 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Ser Asn Met Val Met Tyr Phe Ala Ala Val Leu Leu Gly Gly 195 200 205 Val Pro Phe Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Val Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Pro Gln Ser Ser Asn Ser Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Thr Leu Met Arg Phe 290 295 300 Ser Arg Met Ser Ala Leu Lys Trp Pro Thr Val Leu Gly 305 310 315 <210> 899 <211> 933 <212> DNA <213> Canis familiaris <400> 899 atggaaccag gaaatgattc acaaatttca gagtttcttc ttttgggatt atctgaggaa ccagaactgc agcccctcct atttgggctt ttcctctcca tgtacctgat cactatcttt ggaaacctgc tcataatcct ggctgtcagg tcagaccctc acctccatac cccgatgtac

120

180

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ttcttccttg ccaacctgtc ctttgtagac atctgtttca cctccaccac cgtccccaag 240 atgctcctga acattcagac tcagattaaa gtcatcacct ataaaggctg catcactcag 300 atatactttt tcctcctctt cactgcactg gatgactttc tcctggctgt gatggcctat 360 gaccgcctcg tggccatctg tcaccccctg cactacaggg tcatcatgaa acctacctgc 420 tgtgcactgc tggttctgat gtcctggatg ataagtgcgc tgaattcctt attacaaagc 480 ttaatggtat tgtggctgtc cttctgttca gaggtggaaa tctcccactt cttttgtgaa 540 ctcaatcaag tggtccaact tgcctgttct gacacctttc ttaatgacct ggtgatgtat 600 tttgcagctg tttttctggc tggtggtccc ctcactggga tactttactc ttactctaag 660 atagtttcct ccatacagag aatctcatct gctcagggca agtataaagc attttccacc 720 tgtgcatctc acctcttggt tgtctcttta ttttattgta cactcatagg agtgtacctt 780 agctctgctg ctacccagag ctctcattca agtgcagtgg cctcagtaat atacacagtg 840 gtcacgccca tgctgaaccc cttcatctac agcctgagga acaaagacat aaagagggct 900 ctgaaaagaa tcattggagt tccagtgatg taa 933

<210> 900 <211> 310 <212> PRT <213> Canis familiaris <400> 900

Met Glu Pro Gly Asn Asp Ser Gln Ile Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Ser Glu Glu Pro Glu Leu Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Ile Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Arg Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80

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Met Leu Leu Asn Ile Gln Thr Gln Ile Lys Val Ile Thr Tyr Lys Gly 85 90 95 Cys Ile Thr Gln Ile Tyr Phe Phe Leu Leu Phe Thr Ala Leu Asp Asp 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Leu Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Arg Val Ile Met Lys Pro Thr Cys Cys Ala Leu Leu 130 135 140 Val Leu Met Ser Trp Met Ile Ser Ala Leu Asn Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Val Leu Trp Leu Ser Phe Cys Ser Glu Val Glu Ile Ser His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Val Val Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asp Leu Val Met Tyr Phe Ala Ala Val Phe Leu Ala Gly 195 200 205 Gly Pro Leu Thr Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Gln Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Leu Val Val Ser Leu Phe Tyr Cys Thr Leu Ile 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Val Ala Ser Val Ile Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285

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Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Arg Ala Leu Lys Arg Ile 290 295 300

Ile Gly Val Pro Val Met

305 310 <210> 901 <211> 930 <212> DNA <213> Canis familiaris <400> 901

atggaactag agaatgatac acaaatttca gaatttcttc ttctgggatt ttcagaggaa 60 ccagaattgc agcccttcct ctttggactg ttcctgttca tgtacttggt caccatactt 120 gggaacctgc tcatcattct ggctgtcagc tatgacaccc acctccacac ccccatgtac 180 ttcttccttg ccaacctgtc ctttgtagac atctgtttca cctccactac agtccccagg 240 atgctggtaa atatacaaac acagagaaaa gtcataattt atgaaagctg catcatgcag 300 atgtactttt tcttactttt tgctggtttg gacaactttc ttctgagtgt tatggcctat 360 gaccgatttg tggccatctg tcaccccctg cactacatgg tcaccatgaa cccccagctc 420 tgtggactgc tggttctggt gtcctggatc atgagtgccc tgcattcttt gttacaaaca 480 ttaatggtgt tgcggttgtc cttccataca gaggtggaaa tcccccactt tttctgtgaa 540 ctcaatcaga tgatccagct tgcctgttct gacacctttc ttaataacat ggtgttgtac 600 tttgcagcta tgctgctggc tggtatcccc atggctgggg tcctctactc ttattgtaag 660 atagtttcct ctatacgtag aatctcatca gctcagggca agcataaagc attttccacc 720 tgtgcatcac atctttcagt tgtctcttta ttttattgta cgagcctagg tgtgtacctt 780 agctctgcag ctacccagag ctcccactca agtgcagtag cctcagtgat gtacacggtg 840 gtcacaccca tgctgaatcc ctttatttac agcctgagga acaaagatat aaaggaggca 900 ctaagtgtgt ttttcagagg gaagacataa 930

<210> 902 <211> 309 <212> PRT <213> Canis familiaris

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<400> 902 Glu Phe Leu Leu Leu 15 Gly Met 1 Glu Leu Glu Asn Asp 5 Thr Gln Ile Ser 10 Phe Ser Glu Glu Pro Glu Leu Gln Pro Phe Leu Phe Gly Leu Phe Leu 20 25 30 Phe Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Tyr Asp Thr His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Arg 65 70 75 80 Met Leu Val Asn Ile Gln Thr Gln Arg Lys Val Ile Ile Tyr Glu Ser 85 90 95 Cys Ile Met Gln Met Tyr Phe Phe Leu Leu Phe Ala Gly Leu Asp Asn 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Met Val Thr Met Asn Pro Gln Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Met Ser Ala Leu His Ser Leu Leu Gln Thr 145 150 155 160 Leu Met Val Leu Arg Leu Ser Phe His Thr Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Met Val Leu Tyr Phe Ala Ala Met Leu Leu Ala Gly 195 200 205

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Ile Pro Met Ala Gly Val Leu Tyr Ser Tyr Cys 215 Lys 220 Ile Val Ser Ser 210 Ile Arg Arg Ile Ser Ser Ala Gln Gly Lys His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Glu Ala Leu Ser Val Phe 290 295 300 Phe Arg Gly Lys Thr

305 <210> 903 <211> 369 <212> DNA <213> Canis familiaris <400> 903 aagatggcag ctgacttcct gcagggagag ggctccatct cctttgaagg ttgtgcagct cagatgttct tcctgatgct actgggtgtc tctgagggtg tcctactatc cctcatgtcc tatgactgct atgttgctgt gtgtcacccc ctgcattatc ctgtgctcat gaggtgtcaa gtctgtctgc tcatggtggg cacctcctgg ttgtcaggtg tgcttgtggc ctccacccag acctccatca ccctgcactt cccctactgt gcctcacaca ctgtggatca cttcttctgt gagtttctta gaatcacaat tttaagatgc atatctgttg gggcacctga gtggctcact cagtcaagt

120

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360

369 <210> 904

Page 1016

069269_0225_SL.TXT <211> 123 <212> PRT <213> Canis familiaris <400> 904

Lys Met Ala Ala Asp Phe Leu Gln Gly Glu Gly Ser Ile Ser Phe Glu 1 5 10 15 Gly Cys Ala Ala Gln Met Phe Phe Leu Met Leu Leu Gly Val Ser Glu 20 25 30 Gly Val Leu Leu Ser Leu Met Ser Tyr Asp Cys Tyr Val Ala Val Cys 35 40 45 His Pro Leu His Tyr Pro Val Leu Met Arg Cys Gln Val Cys Leu Leu 50 55 60 Met Val Gly Thr Ser Trp Leu Ser Gly Val Leu Val Ala Ser Thr Gln 65 70 75 80 Thr Ser Ile Thr Leu His Phe Pro Tyr Cys Ala Ser His Thr Val Asp 85 90 95 His Phe Phe Cys Glu Phe Leu Arg Ile Thr Ile Leu Arg Cys Ile Ser 100 105 110 Val Gly Ala Pro Glu Trp Leu Thr Gln Ser Ser 115 120

<210> 905 <211> 948 <212> DNA <213> Canis familiaris <400> 905 atggccatgg aagacgcaaa tctcacgtca gtcactgagt tcctgctcct gggcctttca gagaacccca agcaacagca gctgctgttc ataatcttcc tgactatgta cctggtcacg gggctgggaa acctgctcat catcctggct attgccactg acccccgact ccacacgccc atgtacttct tcctggctaa cttggccttt gtggacattt gcttcacctc caccaccatt cccaagatgc tagccaacca cgtatcagga cacaaaggga tcccttatgc gggctgcctg

120

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Page 1017

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acccagatgt ttttcttcat ctggtttgct ggcatcgata gcttcctgct ggctgccatg 360 gcctatgacc gctatgtggc catctgtcac cctctgcact acaccacatc tgtaacgcca 420 cagctctgtg gattcctggt ggctgcatcc tggactgcag ccttcgggaa tgccctaacc 480 cacactgtat tactgactcg cctctcattc tgcacccaca accgggttcc ccatttcttt 540 tgtgacctca gccctctgct gaagttggcc tgctctgaca tctttctcaa taatgcaatg 600 gtatatacct tgggcgccct accgaccatc ataccctttg tgggcatctt ggtctcttac 660 acatgcatct ttgctacggt gctgaggatc ccttccacca gaggcaagca gaaagctttc 720 tccacctgtg gctctcatct gtctgtggtg tccctattct acgggacact cattggggtt 780 tatttcagcc caatgtcctc ccacacggcc cagaaggaca cagccgctgc ggtgatgtac 840 accgtggtca ctcccatgct gaaccccttc atctacagcc tacgcaacag tgacatgaag 900 ggggctttgg gggccctcat caataggaag ccagttttta gtcagtga 948

<210> 906 <211> 315 <212> PRT <213> Canis familiaris <400> 906

Met Ala Met Glu Asp Ala Asn Leu Thr Ser Val Thr Glu Phe Leu Leu 1 5 10 15 Leu Gly Leu Ser Glu Asn Pro Lys Gln Gln Gln Leu Leu Phe Ile Ile 20 25 30 Phe Leu Thr Met Tyr Leu Val Thr Gly Leu Gly Asn Leu Leu Ile Ile 35 40 45 Leu Ala Ile Ala Thr Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ala Asn Leu Ala Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile 65 70 75 80 Pro Lys Met Leu Ala Asn His Val Ser Gly His Lys Gly Ile Pro Tyr 85 90 95

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Ala Gly Cys Leu Thr Gln Met Phe Phe Phe Ile Trp Phe Ala Gly Ile 100 105 110 Asp Ser Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu His Tyr Thr Thr Ser Val Thr Pro Gln Leu Cys Gly 130 135 140 Phe Leu Val Ala Ala Ser Trp Thr Ala Ala Phe Gly Asn Ala Leu Thr 145 150 155 160 His Thr Val Leu Leu Thr Arg Leu Ser Phe Cys Thr His Asn Arg Val 165 170 175 Pro His Phe Phe Cys Asp Leu Ser Pro Leu Leu Lys Leu Ala Cys Ser 180 185 190 Asp Ile Phe Leu Asn Asn Ala Met Val Tyr Thr Leu Gly Ala Leu Pro 195 200 205 Thr Ile Ile Pro Phe Val Gly Ile Leu Val Ser Tyr Thr Cys Ile Phe 210 215 220 Ala Thr Val Leu Arg Ile Pro Ser Thr Arg Gly Lys Gln Lys Ala Phe 225 230 235 240 Ser Thr Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr 245 250 255 Leu Ile Gly Val Tyr Phe Ser Pro Met Ser Ser His Thr Ala Gln Lys 260 265 270 Asp Thr Ala Ala Ala Val Met Tyr Thr Val Val Thr Pro Met Leu Asn 275 280 285 Pro Phe Ile Tyr Ser Leu Arg Asn Ser Asp Met Lys Gly Ala Leu Gly 290 295 300

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Ala Leu Ile Asn Arg Lys Pro Val Phe Ser Gln 305 310 315 <210> 907 <211> 969 <212> DNA <213> Canis familiaris <400> 907 atggagccag ggaaccttac agaagtttca gagtttcttc ttctgggatt ttcagaggga 60 ccagaactgc agcctctcat ctttgggttt ttcctctcca tgtacctgat cactgtgttt 120 ggaaacctgc ttctcatcct ggctgtcagc tctgactccc acctccacac acccatgtat 180 ttcttcctcg ccaacctgtc ctttgtagac atttgtttca cctccaccac catccccaag 240 atgctgatga atatacagac agagagaaaa gtcattacct atgcagactg catcacccaa 300 atgtattttt tcctactctt tgcaggattg gacaactaca tcttgaccgt gatggcctat 360 gaccgatttt tggccatctg tcaccccctg cactacacag tcatcatgaa tccccagatc 420 tgtggactgc tggttttggt atcttggatc atgagtgccc tgcattcttt gttacaaacc 480 tcagtggtgt tgcggctgtc cttctgtaca gaggtggaaa ttccccactt tttctgtgaa 540 attaaacagt tggtccaact tgcctgttct gacacctttc ttaatgacat ggtgatgtat 600 tttggagctg ggctgctggg tggtggtccc cttgctggga tcctttactc ttattctaag 660 atcatttcct ccatatttgg gatctcatca gctcagggca agtataaagc attttccact 720 tgcgcatctc acctctcagt tgtctcctta ttttactgta caagcctagg agtgtacctt 780 agttctgctg ctccccagac atcacacttg agtgcaacag cctcagtgat gtacacagtg 840 gtcacaccca tgctgaaccc cttcatctac agcctgagaa ataaaggcat aaagagggct 900 ctgaaaagat tctttggaaa acaaagtata aaagggccct tttttctggg gctgaagaaa 960 tacacgtaa 969 <210> 908 <211> 322 <212> PRT <213> Canis familiaris

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<400> 908 Asn Leu Thr Glu Val Ser Glu Phe Leu Leu Leu 15 Gly Met 1 Glu Pro Gly 5 10 Phe Ser Glu Gly Pro Glu Leu Gln Pro Leu Ile Phe Gly Phe Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Leu Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Met Asn Ile Gln Thr Glu Arg Lys Val Ile Thr Tyr Ala Asp 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Leu Leu Phe Ala Gly Leu Asp Asn 100 105 110 Tyr Ile Leu Thr Val Met Ala Tyr Asp Arg Phe Leu Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Gln Ile Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Met Ser Ala Leu His Ser Leu Leu Gln Thr 145 150 155 160 Ser Val Val Leu Arg Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Ile Lys Gln Leu Val Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asp Met Val Met Tyr Phe Gly Ala Gly Leu Leu Gly Gly 195 200 205

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Gly Pro Leu Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Ile Ser Ser 210 215 220 Ile Phe Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Pro Gln Thr Ser His Leu Ser Ala 260 265 270 Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Gly Ile Lys Arg Ala Leu Lys Arg Phe 290 295 300 Phe Gly Lys Gln Ser Ile Lys Gly Pro Phe Phe Leu Gly Leu Lys Lys 305 310 315 320

Tyr Thr <210> 909 <211> 969 <212> DNA <213> Canis familiaris <400> 909

atgaaaccag ccaatgctac acgaatgtca gaattccttc ttctagggtt ttcagaggaa 60 ccagaacttc agcccctcat atttgggctt ttcctatcca tgtacctgat cactgtgttt 120 ggaaacctgc tcatcatcct ggccatcagc tctgaatccc atctccacac ccccatgtac 180 ttcttccttg ccaacctgtc cttggtggac atctgtttca cctccaccac tgtcccaaag 240 atgctgtgga acatccagac tcagagcaaa gtcatcacct atgcaggctg catcacacag 300 atgtattttt tcataatctt ttcaggtttg gacatctatc tcctggctgt gatggcttat 360 gacaggtttg tggccatttg tcaacctcta cactacatgg ccatcatgaa caccaggctc 420

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tgtggactgc tggttctggt atcctggacc acgagtgtct tgcattcctt gttacaaacc 480 tcaatggtgt tgcggctgtc cttctgtaca gaggtggaaa tcccccactt tttctgtgaa 540 ctcaatcaaa tgatccaact tgcctgttct gacacctttc ttaataatgt ggtaatgtat 600 tttgcagcta tgttgctggc tggtggtccc ctcactggga tcctttactc gtattctaag 660 attgtttcct ccatttgtag aatctcatca gctcagggca agtataaagc tttttccacc 720 tgtgcatctc atctctcagt tgtctcctta tttttttgta ctagcctagg agtgtacctt 780 agctctgctg ctacccagag ctcccacgca agtgcagtgg cctcagtgat gtacacagtg 840 ttcacaccca tgctgaaccc gttcatctat agcttgagga acaatgacat aaagacagct 900 ctgaaaagaa tcattggggc tccagtgata ctggggctga agttgtgccc aagattgcag 960

ggctcatag 969 <210> 910 <211> 322 <212> PRT <213> Canis familiaris <400> 910

Met 1 Lys Pro Ala Asn Ala 5 Thr Arg Met Ser Glu Phe Leu Leu Leu Gly 10 15 Phe Ser Glu Glu Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ser Glu Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Leu Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95

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Cys Ile Thr Gln 100 Met Tyr Phe Phe Ile Ile Phe Ser Gly Leu Asp Ile 105 110 Tyr Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Gln 115 120 125 Pro Leu His Tyr Met Ala Ile Met Asn Thr Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Thr Thr Ser Val Leu His Ser Leu Leu Gln Thr 145 150 155 160 Ser Met Val Leu Arg Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Val Val Met Tyr Phe Ala Ala Met Leu Leu Ala Gly 195 200 205 Gly Pro Leu Thr Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Cys Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Phe Cys Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ala Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Phe Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Asn Asp Ile Lys Thr Ala Leu Lys Arg Ile 290 295 300

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Ile Gly Ala Pro Val Ile Leu Gly Leu Lys Leu Cys Pro Arg Leu Gln 305 310 315 320

Gly Ser <210> 911 <211> 474 <212> DNA <213> Canis familiaris <400> 911

ttgttacaaa gtttaatgat gttgtggctt tccttctgta cacaggtgga aatccctcac 60 tttttctgtg aactcaatga gatagtccaa cttgcctgta ctgacacctt tcttaataac 120 ttggtgatgt attttgcagc tgtcctgctg ggtggaagtc cttttgctgg gatcattcac 180 tcttattcta agactgtttc ctccatacat ggaatttcat cagctcgggg caagtataaa 240 gcattttcca cctgtgcgtc tcacctctca gttgtctcct tattttattg tacaatgctt 300 ggtgtatacc ttagctctgc tgctacccag agctcccacg caagtgcagt agcctcggtg 360 atgtacaccg tggtcacacc catgctgaac cccttcatct acagcctgag aaacaaagac 420 ataaagagag ttctgaaagc attctttgcg aaggaaactc tatatggcca attg 474

<210> 912 <211> 158 <212> PRT <213> Canis familiaris <400> 912

Leu 1 Leu Gln Ser Leu 5 Met Met Leu Trp Leu Ser Phe Cys Thr Gln Val 10 15 Glu Ile Pro His Phe Phe Cys Glu Leu Asn Glu Ile Val Gln Leu Ala 20 25 30 Cys Thr Asp Thr Phe Leu Asn Asn Leu Val Met Tyr Phe Ala Ala Val 35 40 45 Leu Leu Gly Gly Ser Pro Phe Ala Gly Ile Ile His Ser Tyr Ser Lys 50 55 60

Page 1025

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Thr 65 Val Ser Ser Ile His Gly Ile Ser Ser Ala Arg Gly Lys Tyr Lys 70 75 80 Ala Phe Ser Thr Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr 85 90 95 Cys Thr Met Leu Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser 100 105 110 His Ala Ser Ala Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met 115 120 125 Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Arg Val 130 135 140 Leu Lys Ala Phe Phe Ala Lys Glu Thr Leu Tyr Gly Gln Leu 145 150 155

<210> 913 <211> 963 <212> DNA <213> Canis familiaris <400> 913

atggaatcag gaaatcaaac acacacttca gaatttctcc tcctcgggtt ttcagggaag 60 ctagagattc agttcatgct ctttgggatg ttcctatctg tatacttggt caccttcgct 120 gggaatctgc tcatcatcct ggccatctgc tcagactccc atctccacac acccatgtat 180 ttcttcctcg ccaacctgtc ctttgctgac atctgtttca cctccaccac catccccaag 240 atgctgttga acattcagac tcagagcaaa accataacat atgaaggatg tctcagtcag 300 atattttttt tcattgtgtt tggatgcctg gacaatttac tcctgaccgt gatggcctat 360 gaccgctttg tggccatctg tcaccccctg cactacttgg tcatcatgaa cccccagctc 420 tgtggactgc tagccttggg gtcttggtgc gtcagtgtca tgggctccct tctcgagacc 480 ttgacccttt tgaggctatc tttctgcaca aacatgaaaa tcccacactt tttttgtgat 540 cttcctgaag tcctgaagct tgcctgttct gacaccctca tcaataacat agtggtgtat 600 tctacaactg ggcttctggc tgtgattcct ttccatggaa tacttttctc gtactatcaa 660

Page 1026

069269_0225_SL.TXT attgtttcct ctgtactcag catttcctca gctgcaggca agtacaaagc cttttccacg tgtttgtctc acctcttggt ggtctccttg ttctatggca caggcctggg ggtctacctc agttctgcag tcacttcatc ctctagaatg agtctggtgg cttcagttat gtacaccatt gtcactccca tgctgaaccc cttcatctat agcttgaaga acagggacat gaagggggct ctgagaagtg tcctgggcag tgtggtacct gtcagcattg ggaccattat aggattctcc tga

720

780

840

900

960

963 <210> 914 <211> 320 <212> PRT <213> Canis familiaris <400> 914

Met Glu Ser Gly Asn Gln Thr His Thr Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Gly Lys Leu Glu Ile Gln Phe Met Leu Phe Gly Met Phe Leu 20 25 30 Ser Val Tyr Leu Val Thr Phe Ala Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Cys Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Ala Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Thr Ile Thr Tyr Glu Gly 85 90 95 Cys Leu Ser Gln Ile Phe Phe Phe Ile Val Phe Gly Cys Leu Asp Asn 100 105 110 Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125

Page 1027

Pro Leu 130 His Tyr Leu Val Ile 135 069269_0225_SL.TXT Met Asn Pro Gln Leu Cys 140 Gly Leu Leu Ala Leu Gly Ser Trp Cys Val Ser Val Met Gly Ser Leu Leu Glu Thr 145 150 155 160 Leu Thr Leu Leu Arg Leu Ser Phe Cys Thr Asn Met Lys Ile Pro His 165 170 175 Phe Phe Cys Asp Leu Pro Glu Val Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Val Val Tyr Ser Thr Thr Gly Leu Leu Ala Val 195 200 205 Ile Pro Phe His Gly Ile Leu Phe Ser Tyr Tyr Gln Ile Val Ser Ser 210 215 220 Val Leu Ser Ile Ser Ser Ala Ala Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Leu Ser His Leu Leu Val Val Ser Leu Phe Tyr Gly Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Val Thr Ser Ser Ser Arg Met Ser Leu 260 265 270 Val Ala Ser Val Met Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Lys Asn Arg Asp Met Lys Gly Ala Leu Arg Ser Val 290 295 300 Leu Gly Ser Val Val Pro Val Ser Ile Gly Thr Ile Ile Gly Phe Ser 305 310 315 320

<210> 915 <211> 930 <212> DNA <213> Canis familiaris

Page 1028

069269_0225_SL.TXT <400> 915 atggaatcag gaaatgatac acaaatttct gaattttttc ttctgggatt ttcagaggaa 60 caagaacagc agcccctcgt tttcgggctt ttcctctcca tgtacctcat cactgtgttt 120 ggaaacctgc tcctcatcct ggccgtcagc tctgactccc atctccacac ccccatgtac 180 ttcttccttg ccaatctgtc ctttgtagac atttgtttca cctccaccac catccccaag 240 atgctgtgga acatccagac tcagagcaaa gtcatcacct atgcaggctg catcactcag 300 atgtactttt tcaccctctt tgctgtgttg gatgtctttc tcctgagtgt gatggcctat 360 gactggtatg tggccatctg tcaccccctg aactacatgg tcttcatgaa ccccctgctc 420 tgtggactgc tggttatggc atcctggatc atgtgtatcc tgaactcctt gttacaaagt 480 ctaatgatgt tgcggctttc cttctgtaca cacctgcata tcccccactt tttctgtgaa 540 ctcaacgaaa tggtccaact tgcctgttct gatacatttc ttaataactt ggtgatgtat 600 tttgcagctg tcctgctggg aggtggtgct tttgctggga tcctttactc ttactctaag 660 atcgtttcct ccatacgtgg aatctcatca gctcagggca agtataaagc attttccacc 720 tgtgcatctc acctctaagt tgtctgttta ttttattgta caatgcttgg tgtgtacctt 780 agctctgctg ctccccagag ctcccacgca agcgcaatag cctcagtgat gtacacggtg 840 gtcacgccca tgctgaaccc cttcatctac agcttgagga acagagacat aaagagggct 900 ctgaaaagaa ttgttagggt tccagtgata 930 <210> 916 <211> 245 <212> PRT <213> Canis familiaris <400> 916

Met 1 Glu Ser Gly Asn Asp Thr Gln Ile Ser Glu Phe Phe Leu Leu Gly 5 10 15 Phe Ser Glu Glu Gln Glu Gln Gln Pro Leu Val Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Leu Ile Leu Ala 35 40 45

Page 1029

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Val Ser 50 Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Thr Leu Phe Ala Val Leu Asp Val 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Trp Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Asn Tyr Met Val Phe Met Asn Pro Leu Leu Cys Gly Leu Leu 130 135 140 Val Met Ala Ser Trp Ile Met Cys Ile Leu Asn Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Met Leu Arg Leu Ser Phe Cys Thr His Leu His Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Glu Met Val Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Leu Val Met Tyr Phe Ala Ala Val Leu Leu Gly Gly 195 200 205 Gly Ala Phe Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu

245

Page 1030

069269_0225_SL.TXT <210> 917 <211> 933 <212> DNA <213> Canis familiaris <400> 917

atggaatcag gaaatgatac acaaatttct gaattttatc ttctgggatt ttcagagaaa 60 ccagaactac agcccctcat atttggactt ttcctctcca tgtacctgat cactgtgttt 120 ggaaatctgc tcatcatcct gtccatcagc acagacccca atctgcacac gcccatgtac 180 ttcttccttg ccaacctgtc ctttgtagac atttgtttca cctccaccac catccccaag 240 atgctgtgga acatccagac tcagagcaaa gtcataagct atgcaggttg cattacacag 300 atttatttcc tcatactctt tgctgtgttg gatgtctttc ttctgagtgt gatggcttat 360 gaccggtatg tggccatctg ccaccccctg cactacatgg tcatcatgaa ccccctgctc 420 tgtggactgc tggttctggt atcctggata atatgtatcc tgaattcctt gctacagagt 480 ttaatgatgt tgcggctttc cttctgtaca cacttgaata tccctcactt tttctgtgaa 540 ctcaatgaaa tggtccaact tgcctgttct gacacctttc ttaataactt ggtgatgtat 600 tttgcagctc tcctgctggg tgggggtcct tttgctggga tcctttactc ttattctaag 660 atcgtatcct ccatacgtgg aatatcatca gctcagggca agtataaagc attttccacc 720 tgtgcatctc acctctcggt tgtctgttta ttttattgta cgatgcttgg tgtgtacctt 780 agctctgctg ctacccagag ctcccacgca agtgcagtgg cctcggtgat gtacacggtg 840 gtcacaccca tgctgaaccc cttcatctat agtctgagga acagagacat aaaaatggct 900 ctgagaagaa tcattggggt tccagtgatg taa 933

<210> 918 <211> 310 <212> PRT <213> Canis familiaris <400> 918

Met Glu Ser Gly Asn Asp Thr Gln Ile Ser Glu Phe Tyr Leu Leu Gly 1 5 10 15 Phe Ser Glu Lys Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu

20 25 30

Page 1031

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Ser Met Tyr 35 Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ser 40 45 Ile Ser Thr Asp Pro Asn Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Lys Val Ile Ser Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Ile Tyr Phe Leu Ile Leu Phe Ala Val Leu Asp Val 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Met Val Ile Met Asn Pro Leu Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Ile Cys Ile Leu Asn Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Met Leu Arg Leu Ser Phe Cys Thr His Leu Asn Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Glu Met Val Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Leu Val Met Tyr Phe Ala Ala Leu Leu Leu Gly Gly 195 200 205 Gly Pro Phe Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240

Page 1032

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Cys Ala Ser His Leu 245 Ser Val Val Cys Leu Phe Tyr Cys Thr Met Leu 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ala Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Met Ala Leu Arg Arg Ile 290 295 300 Ile Gly Val Pro Val Met

305 310 <210> 919 <211> 861 <212> DNA <213> Canis familiaris <400> 919 cagtttcttc ttctgggatt atcagaggaa ccagaattac agcccctcct atttgggatg ctcctctcca tgtacctgat cactgtgctt ggaaacctgc tcatcatcct ggtcatcagc acagatccca gcctcctcac ccccgtgtac ttcttcctca ccaacctctc ctttgtcaac atctgtttca cctccaccac tgtcctgaag atgctgcaga atatcaagac tcagagcaag gtaatcacct atgtagcctg catcacacag atgtacttta tagtaatctt tacagtgttg gacatggatc ttctggccgt gatgacttat gaccgacatg tggccatctg tcaccccccc ctgcactaca tggtcatcat gaacccctgg ttctgtgtgt ggctggttct tgtgccctgg gtcataggtg tcttgtattt cttgttataa acctcaatgg tgttgcaact gtccttctat agagaggtgg aaatccctcc ctttttctgt gaactcagtc agatgaccca acttgccttt tctgacatct ttcttagtaa aatggtaacg tattttgtag ctacgtttct ggggttggtc ccctcactgg gaggtcccct cactgggata atttactttt attctaagat aatctccata tgtggaatct catcagctca gggcaagtat aaagcatttt ccacctgtgc ttctcacctc

120

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Page 1033

069269_0225_SL.TXT tttgttgtct ccttatttta ttctatggac ctaggagtgt accttagttc tgctgctccc cagagctccc actcaagtgc agtagcctca gtgatgtatg tggtggtcaa ccccatgctg aaccccttca tcttcagcct g

780

840

861 <210> 920 <211> 149 <212> PRT <213> Canis familiaris <400> 920

Gln Phe Leu 1 Leu Leu Gly Leu Ser 5 Glu Glu Pro Glu Leu Gln Pro Leu 10 15 Leu Phe Gly Met Leu Leu Ser Met Tyr Leu Ile Thr Val Leu Gly Asn 20 25 30 Leu Leu Ile Ile Leu Val Ile Ser Thr Asp Pro Ser Leu Leu Thr Pro 35 40 45 Val Tyr Phe Phe Leu Thr Asn Leu Ser Phe Val Asn Ile Cys Phe Thr 50 55 60 Ser Thr Thr Val Leu Lys Met Leu Gln Asn Ile Lys Thr Gln Ser Lys 65 70 75 80 Val Ile Thr Tyr Val Ala Cys Ile Thr Gln Met Tyr Phe Ile Val Ile 85 90 95 Phe Thr Val Leu Asp Met Asp Leu Leu Ala Val Met Thr Tyr Asp Arg 100 105 110 His Val Ala Ile Cys His Pro Pro Leu His Tyr Met Val Ile Met Asn 115 120 125 Pro Trp Phe Cys Val Trp Leu Val Leu Val Pro Trp Val Ile Gly Val 130 135 140

Leu Tyr Phe Leu Leu 145

Page 1034

069269_0225_SL.TXT <210> 921 <211> 951 <212> DNA <213> Canis familiaris <400> 921

atgaaatcag gaaatcaaac acatgcttca gaatttctcc tcctgggatt ttcagagaag 60 tcagagattc agttcatgct ctttgggttg ttcctgtcca tatacttggt ctcgttcact 120 gggaatctgc tcatcatcct ggccatctgc tcagactccc gtctccacac acccatgtat 180 ttcttccttg ccaacttgtc ctttgctgac atctgtttca cctccaccac agtccccaag 240 atgctggtga acatccagac tcagagcaaa accataacat atgaaggatg tctcagccag 300 atattttttt tctttgtgtt tggatgcctg gacaatttac tcctgaccgt gatggcctat 360 gaccgctttg tggccatctg tcaccccccg cactactcac tcatcatgaa cccgcagctc 420 tgtgggttgc tggccctggg gtcctggtgc atcagtgtaa tgggctccct tttcgagacc 480 ttgacccttt tgaggctacc cttctgcaca aacatggaaa tatcacactt tttttgtgat 540 cttcctgaag tcttgaagct tgcctgttct gacaccctta tcaataacat agtggtgtat 600 tttgtgacta ttgtcctagg tgtttttcct ctctctggga tccttttttc ttattctcag 660 attttctcct ccatcttgag aatttcctca actgcagata agtacaaagc cttttccaca 720 tgtgggtctc atctctcagt ggtctgcttg ttctatggca caagcctagg ggactacctc 780 agttctgcag caactacatc ctccaggaca agtctggtgg cctcagtgat gtacgccatt 840 gtcaccccta tgctgaaccc cttcatctac agcttgagga atggggacat gaagggggcc 900 ctgggtaggt tggtgcctct cagcatcagg accattacag gactctcctg a 951

<210> 922 <211> 316 <212> PRT <213> Canis familiaris <400> 922

Met Lys Ser Gly Asn Gln Thr His Ala Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Glu Lys Ser Glu Ile Gln Phe Met Leu Phe Gly Leu Phe Leu 20 25 30

Page 1035

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Ser Ile Tyr 35 Leu Val Ser Phe Thr Gly Asn Leu Leu Ile Ile Leu Ala 40 45 Ile Cys Ser Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Ala Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr Gln Ser Lys Thr Ile Thr Tyr Glu Gly 85 90 95 Cys Leu Ser Gln Ile Phe Phe Phe Phe Val Phe Gly Cys Leu Asp Asn 100 105 110 Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Pro His Tyr Ser Leu Ile Met Asn Pro Gln Leu Cys Gly Leu Leu 130 135 140 Ala Leu Gly Ser Trp Cys Ile Ser Val Met Gly Ser Leu Phe Glu Thr 145 150 155 160 Leu Thr Leu Leu Arg Leu Pro Phe Cys Thr Asn Met Glu Ile Ser His 165 170 175 Phe Phe Cys Asp Leu Pro Glu Val Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Val Val Tyr Phe Val Thr Ile Val Leu Gly Val 195 200 205 Phe Pro Leu Ser Gly Ile Leu Phe Ser Tyr Ser Gln Ile Phe Ser Ser 210 215 220 Ile Leu Arg Ile Ser Ser Thr Ala Asp Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240

Page 1036

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Cys Gly Ser His Leu 245 Ser Val Val Cys Leu Phe Tyr Gly Thr Ser Leu 250 255 Gly Asp Tyr Leu Ser Ser Ala Ala Thr Thr Ser Ser Arg Thr Ser Leu 260 265 270 Val Ala Ser Val Met Tyr Ala Ile Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Gly Asp Met Lys Gly Ala Leu Gly Arg Leu 290 295 300 Val Pro Leu Ser Ile Arg Thr Ile Thr Gly Leu Ser 305 310 315

<210> 923 <211> 933 <212> DNA <213> Canis familiaris <400> 923 atggaatcag acaacgatac acgaatttca gagttccttc ttctgggatt ctcaggggaa tcagaactgc agcccctcat atttgggctt ttcctctcca tgtacctcat cactgtgttt ggaaacttgc taatcatcct ggctgtcagc tctgactccc acctccacac ccccatgtac ttcttcctca ccaacctgtc ctttgtagac atctgtttca tctccactac tgtccccaag atgctccaga acattcagac tggaagtaaa gtcataacct acccaggctg catcacacag atatactttt tcctactctt tgcaggatgt gatgattttc tcctgagtat gatggcctat gaccgctttg tggccatctg ccatcccctg cactacacag tcatcatgaa cccctggttc tgtgtactgc ttgttctggt ggcctggatc accagtgttc tcaattcctt gttacagagc ttaatggtgt tacagctgtc cttctgtgca ggcatggaaa tcccccattt tttctgtgac ctcaatcagg taattgggca cgcctgttct gacagatttc ttaatgaggt ggtgatgtat tttgcaactg tgctgctggg tgtggctccc ttgcctggga tccttttctc ttactctaag atagtttcct ccatatgtgg aatatcatcg attcagggta agtataaagc attttccacc

120

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240

300

360

420

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540

600

660

720

Page 1037

069269_0225_SL.TXT tgtgcatctc acctctcagt tgtctcctta ttttactgta caggcttagg agtatacctt agctctgctg tgccccaagg ctcccatgca agtgtagtgg cctcggtgat gtacacagtg gtcacgccca tgctgaaccc cttcatctac agcctgagga acagagatat aaagagggct ctgaaaagaa tcattggggt tcctgtgatg taa

780

840

900

933 <210> 924 <211> 310 <212> PRT <213> Canis familiaris <400> 924

Met Glu Ser Asp Asn Asp Thr Arg Ile Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Gly Glu Ser Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Gln Asn Ile Gln Thr Gly Ser Lys Val Ile Thr Tyr Pro Gly 85 90 95 Cys Ile Thr Gln Ile Tyr Phe Phe Leu Leu Phe Ala Gly Cys Asp Asp 100 105 110 Phe Leu Leu Ser Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Trp Phe Cys Val Leu Leu 130 135 140 Val Leu Val Ala Trp Ile Thr Ser Val Leu Asn Ser Leu Leu Gln Ser

Page 1038

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145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Ala Gly Met Glu Ile Pro His 165 170 175 Phe Phe Cys Asp Leu Asn Gln Val Ile Gly His Ala Cys Ser Asp Arg 180 185 190 Phe Leu Asn Glu Val Val Met Tyr Phe Ala Thr Val Leu Leu Gly Val 195 200 205 Ala Pro Leu Pro Gly Ile Leu Phe Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Cys Gly Ile Ser Ser Ile Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Val Pro Gln Gly Ser His Ala Ser Val 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Lys Arg Ile 290 295 300 Ile Gly Val Pro Val Met 305 310

<210> 925 <211> 915 <212> DNA <213> Canis familiaris <400> 925 atgggaccag gaaatgatac acaaatttca agatttcttc ttttaggatt gtcaaataaa ccaggacttc agctccccat atttggactt ttcctcttca tgtacctcat cactgtgttt

120

Page 1039

069269_0225_SL.TXT

ggaaacttgc tcattatcct ggctgttggc tctgactctc acctccacac tcccatgtac 180 ttctttctgg ccaacttgtc ctttgtagac atctgtttca cctcaaccac catcccaaga 240 cccaagatgc tgataaatat acagacacag agcaaattta tatcatatac aggatgcatc 300 agccagatct gctttttctt actctttgca ggctgggatg actttctctt ggctgtgatg 360 gcctatgatc gttttgtggc catctgtcac ccattgcact acatggtcat catgaatccc 420 cgggtctgtg gactgctggt tctggtgtcc tggatcatca gtgttctgaa ttccttatta 480 cagagcttaa tggttttgca gctttccttc tgttcagagg tggaaatccc tcactttttc 540 tgtgaactcc atcagatgat ccaacttgcc tgttctgata cctttcttaa tgacacaata 600 atatatgttt cagctgtgct gttggctggc ggtccccttg ctgggatcct ttgctcatat 660 tccaagatta tttcctccat acatagaata tcatcagctc agggcaagta taaagcattt 720 tccacctgtg tatctcatct cttggttgtt tccttatttt attgcactgt cctgggagtg 780 taccttagct ctgctgttac ccagagctcc catgcaagtg cagtagcctc agtaatgtac 840 atggtcatca cgcccatgct gaaccccttc atctacagtc tgaggaacaa agatataaag 900 gaggctctga tgaga 915

<210> 926 <211> 305 <212> PRT <213> Canis familiaris <400> 926

Met Gly Pro Gly Asn Asp Thr Gln Ile Ser Arg Phe Leu Leu Leu Gly 1 5 10 15 Leu Ser Asn Lys Pro Gly Leu Gln Leu Pro Ile Phe Gly Leu Phe Leu 20 25 30 Phe Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Gly Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60

Page 1040

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Asn 65 Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Arg 70 75 80 Pro Lys Met Leu Ile Asn Ile Gln Thr Gln Ser Lys Phe Ile Ser Tyr 85 90 95 Thr Gly Cys Ile Ser Gln Ile Cys Phe Phe Leu Leu Phe Ala Gly Trp 100 105 110 Asp Asp Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile 115 120 125 Cys His Pro Leu His Tyr Met Val Ile Met Asn Pro Arg Val Cys Gly 130 135 140 Leu Leu Val Leu Val Ser Trp Ile Ile Ser Val Leu Asn Ser Leu Leu 145 150 155 160 Gln Ser Leu Met Val Leu Gln Leu Ser Phe Cys Ser Glu Val Glu Ile 165 170 175 Pro His Phe Phe Cys Glu Leu His Gln Met Ile Gln Leu Ala Cys Ser 180 185 190 Asp Thr Phe Leu Asn Asp Thr Ile Ile Tyr Val Ser Ala Val Leu Leu 195 200 205 Ala Gly Gly Pro Leu Ala Gly Ile Leu Cys Ser Tyr Ser Lys Ile Ile 210 215 220 Ser Ser Ile His Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe 225 230 235 240 Ser Thr Cys Val Ser His Leu Leu Val Val Ser Leu Phe Tyr Cys Thr 245 250 255 Val Leu Gly Val Tyr Leu Ser Ser Ala Val Thr Gln Ser Ser His Ala 260 265 270

Page 1041

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Ser Ala Val Ala Ser Val Met Tyr Met Val Ile Thr Pro Met Leu Asn 275 280 285

Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Glu Ala Leu Met 290 295 300

Arg

305 <210> 927 <211> 930 <212> DNA <213> Canis familiaris <400> 927

atggaactag agaatgatac acgaattcca gaatttctcc ttctgggatt ttcagaggaa 60 ccaaaattgc agcccttcct ctttgggctg ttcctgtcca tgtacctggt caccatactt 120 gggaacctgc tcctcatcct ggctgtcagc tctgactctc acctccacac ccccatgtac 180 ttcttccttg ccaatctgtc ctttgtagac atctgtttca cctgtaccac catcccaaag 240 atgctggtaa atatacaaac acaaagaaaa gtcataactt atgagagctg catcatacag 300 atgtactttt tcatactttt tgcaggtata gacaatttcc tcctgactgt gatggcctat 360 gatcgctaca tggccatctg ctaccccctg cactacatgg tcatcatgaa ccctcagctc 420 tgttcactac tactactggt atcctggatc atgagtgcct tgcattcttt gttacaaacc 480 ttaatggtgt tgcgactgtc cttctgtaca catttccaaa tcccccactt tttctgtgaa 540 ctcaatcaga tgatccaact tgcctgttct gacacctttc ttaataacat gatgttgtat 600 tttgcagcta tattgctggg ggttgctccc ctggttggag tcctttactc ttatttcaag 660 atagtttcct ctatacgtgg gatctcatca gctcacagca agtataaagc attttccacc 720 tgtgcttctc acctctcggt tgtctcctta ttttattgta caagcctagg agtgtacctt 780 agctccgctg ctccccagag cacccacaca agttcagtgg cctcagtgat gtacacagtg 840 gtcaccccca tgctgaaccc cttcatctac agcctcagga acaaagacat aaagggagct 900 ctaaatgtat ttttcagagg gaagccataa 930

<210> 928

Page 1042

069269_0225_SL.TXT <211> 309 <212> PRT <213> Canis familiaris <400> 928

Met Glu Leu Glu Asn Asp Thr Arg Ile Pro Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Glu Glu Pro Lys Leu Gln Pro Phe Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Leu Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Cys Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr Gln Arg Lys Val Ile Thr Tyr Glu Ser 85 90 95 Cys Ile Ile Gln Met Tyr Phe Phe Ile Leu Phe Ala Gly Ile Asp Asn 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Tyr 115 120 125 Pro Leu His Tyr Met Val Ile Met Asn Pro Gln Leu Cys Ser Leu Leu 130 135 140 Leu Leu Val Ser Trp Ile Met Ser Ala Leu His Ser Leu Leu Gln Thr 145 150 155 160 Leu Met Val Leu Arg Leu Ser Phe Cys Thr His Phe Gln Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190

Page 1043

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Phe Leu Asn Asn Met Met Leu Tyr Phe Ala Ala Ile Leu Leu Gly Val 195 200 205 Ala Pro Leu Val Gly Val Leu Tyr Ser Tyr Phe Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ala His Ser Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Pro Gln Ser Thr His Thr Ser Ser 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Gly Ala Leu Asn Val Phe 290 295 300 Phe Arg Gly Lys Pro

305 <210> 929 <211> 933 <212> DNA <213> Canis familiaris <400> 929

atggaacctg gaaatgatac acaaattcca gagtttcttc ttctgggatt atcagaggaa 60 tcagaactac agcccctcct atttgggctt ttcctctcca tgtacctgat cactgtgttt 120 ggaaacctgc tcatcatcct ggctgtcacc tctgaccctc acctccacac ccccatgtac 180 ttcttcctcg ccaacctgtc ttttgtagac atctgttcca tctccaccac cgtccccaaa 240 atgctccaaa acatccagac tcagagcaaa gttattacct atgcaggttg tgttactcaa 300 atatactttt tcttactctt tgcagggtgg gatgactttc tcctggctgt gatggcctat 360 gacaggtttg tggccatctg tcaccccctg cactacacag tcatcataaa ttcccagctc 420

Page 1044

069269_0225_SL.TXT

tgtgtgctgt tggttctggt gtcctggatc atcagtgtcc tgcattcctt attagaaagc 480 ttaatggtgt tgcagctgtc cttctgcaga gaggtggaaa tctcccactt tttctgtgaa 540 attaatcagg tggtccgact tgcctgttca aacacctttc ttaatgacat gctgatgtat 600 ttggcagctg tgctgctggc tggtggtccc cttgctggga tcatttactc atattttaag 660 atagtttcct ccatacttcg gatctcatca gctcagggca agtataaggc attttccacc 720 tgtacgtctc acctctcagt tgtgttctta ttttattgta caatcctagg agtgtacctt 780 agctctgctg ttccccagag ctcccactca agtgcactgg cctcagtgat gtacacagtg 840 gtcacaccca tgctgaaccc cttcatttat agtctgagga acagagacat aaaaagggct 900 ctgaaaagaa tctttggggt tccagtgatg taa 933

<210> 930 <211> 310 <212> PRT <213> Canis familiaris <400> 930

Met Glu Pro Gly Asn Asp Thr Gln Ile Pro Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Ser Glu Glu Ser Glu Leu Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Thr Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Ser Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Gln Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Val Thr Gln Ile Tyr Phe Phe Leu Leu Phe Ala Gly Trp Asp Asp 100 105 110

Page 1045

069269_0225_SL.TXT

Phe Leu Leu 115 Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 120 125 Pro Leu His Tyr Thr Val Ile Ile Asn Ser Gln Leu Cys Val Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Ile Ser Val Leu His Ser Leu Leu Glu Ser 145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Arg Glu Val Glu Ile Ser His 165 170 175 Phe Phe Cys Glu Ile Asn Gln Val Val Arg Leu Ala Cys Ser Asn Thr 180 185 190 Phe Leu Asn Asp Met Leu Met Tyr Leu Ala Ala Val Leu Leu Ala Gly 195 200 205 Gly Pro Leu Ala Gly Ile Ile Tyr Ser Tyr Phe Lys Ile Val Ser Ser 210 215 220 Ile Leu Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Thr Ser His Leu Ser Val Val Phe Leu Phe Tyr Cys Thr Ile Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Val Pro Gln Ser Ser His Ser Ser Ala 260 265 270 Leu Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Lys Arg Ile 290 295 300 Phe Gly Val Pro Val Met

305 310

Page 1046

069269_0225_SL.TXT <210> 931 <211> 495 <212> DNA <213> Canis familiaris <400> 931 gtcatcatga aacccaccta ctgtgtactg ttggttctgg tggtctggat gataagtatc 60 ctgaattcct tattacaaag cttaatggtg ttgtgactgt ccttctgtag agaggtggaa 120 atttccaact ttttctgtga tgtcaaacaa gtggttcaac ttgcctattc tgacctttct 180 taatgacatg gtgatgtatt taacagctgt gctgctgggt ggtgtcccct cactgggatc 240 atttattttt actctaagat agtttcctcc atacttggga tctcatcatc tcagggcaag 300 tataaagcat tttccacctg tgcatctcac ctctccattg tgttcttatt gtattgtaca 360 atcctgtacc ttagctctgc tgctcccaaa agctcccttt caagtgctgt agcctcggtg 420 atgtacacag tggtcatacc catgctgaac cccttcatct atagcctgag gaacagagat 480 ataaagagag atctg 495 <210> 932 <211> 35 <212> PRT <213> Canis familiaris <400> 932

His His Glu Thr His Leu Leu Cys Thr Val Gly Ser Gly Gly Leu Asp 1 5 10 15 Asp Lys Tyr Pro Glu Phe Leu Ile Thr Lys Leu Asn Gly Val Val Thr 20 25 30

Val Leu Leu 35 <210> 933 <211> 948 <212> DNA <213> Canis familiaris <400> 933 atggggcaag gcaatgatac agaaatttca gagtttcttc ttctgggatt gtcagaggaa 60

Page 1047

069269_0225_SL.TXT

ccagaactgc agcccctcct atttgggctc ttcctctcca tgtacctgat cactatcttt 120 ggaaacctgc tcatcatcct ggctgtcagc tgtgaccccc acctccacac ccccatgtac 180 ttcttcctca ccaacctgtc ctttgtagac atctgtttca cctccaccac tgtccccaag 240 atgcttcaga atatccagac tcagagcaaa gtcatcacct atgcaggttg tgtcacacag 300 atttattttt ttatactctt tgctgtctca gacttctttg tcctcagtgt gatggcctat 360 gaccggtttg tggccatctg ttatcccctg cactacacag tcatcatgaa ctcccgactt 420 tgtggacttc tggttctggt gtcttggatc atgtgtatcc tgaactcctt gttacagagt 480 ttaatgatgt tgcggctttc cttctgtaca cacttccaaa tcccccactt tttttgtgaa 540 ctcaatcaga tgatccaact agcctgttct gacacctttc ttaataacat ggtgatgtat 600 tttgcagctg tcttactggg tgggggtcct tttgctggga tcctttactc ttattctaag 660 attgtttcca ccatatgtgg aatatcatca gccctgggca agtataaagc attttccacc 720 tgtgcatctc acctctcagt tgtctcctta ttttattgta caatcctagg tgtgtacctt 780 agctctgctg ctcctcagag ctctcactca agtgcagtgg cctcggtgat gtacacagtg 840 gtcacaccca tgttgaaccc cttcatctat agcctgagga acagagacat aaagaaggct 900 ttaagagcat tcttagtaaa ggagacacta catggccaat tgtcatag 948

<210> 934 <211> 315 <212> PRT <213> Canis familiaris <400> 934

Met Gly Gln Gly Asn Asp Thr Glu Ile Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Ser Glu Glu Pro Glu Leu Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Ile Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Cys Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60

Page 1048

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Asn 65 Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 70 75 80 Met Leu Gln Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Val Thr Gln Ile Tyr Phe Phe Ile Leu Phe Ala Val Ser Asp Phe 100 105 110 Phe Val Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Tyr 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Ser Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Met Cys Ile Leu Asn Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Met Leu Arg Leu Ser Phe Cys Thr His Phe Gln Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Met Val Met Tyr Phe Ala Ala Val Leu Leu Gly Gly 195 200 205 Gly Pro Phe Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Thr 210 215 220 Ile Cys Gly Ile Ser Ser Ala Leu Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Ile Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Pro Gln Ser Ser His Ser Ser Ala 260 265 270

Page 1049

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Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Lys Ala Leu Arg Ala Phe 290 295 300 Leu Val Lys Glu Thr Leu His Gly Gln Leu Ser 305 310 315

<210> 935 <211> 930 <212> DNA <213> Canis familiaris <400> 935

atggaactag agaatgatac acgaatttca gaatttcttc ttctgggatt ttcggagaaa 60 ccagaattgc agcccttcct ctttgggctt ttcctgtccc tgtacctggt caccatattt 120 gggaacctgc tcatcatcct ggtcttcagt tctgactccc acctccacac gcccatgtac 180 ttctttctgg ccaacctgtc ctttgtagac atctgtttca cctccacaac catccctaag 240 ctgctggtga atatacaaac acagagaaaa gtcataactt acaaaagctg catcatgcag 300 atgtactttt tcatactttt tataggttta gacaactttc tcctgactgt aatggcttat 360 gaccgattca tggccatctg tcaccccctg cactacacag tcatcatgaa ccctcggctc 420 tgtgcactgt tggttttggt gtcctggatc ataagtgccc tgcactcctt gttagaaagc 480 ttaatggtgt tgcagctgtc cttctgtaca gccttggaaa tcccccactt tttttgtgaa 540 ctcaatcaga tgatccaact tgcctgttct gacacctttc ttaatgattt ggtgatgtat 600 tgtgcaactg tgctgctggt tggtgctccc ctggctgggg tcctttactc ttattctaag 660 atcctttctt ccatacgtgg aatatcatca gctcagggaa agcataaagc attttccacc 720 tgtgcatctc acctctcagt tgtctcctta ttttactgta caggcctagg agtgtacctt 780 agctctgatg ctccccagag ctcccactca agtgcagcag cctccatgat gtacacggta 840 gtcacaccca tgctgaaccc cttcatctac agcctcagga acaaagacat aaaggaggct 900 ctaactgtat ttttcagagg gaagccataa 930

Page 1050

069269_0225_SL.TXT <210> 936 <211> 309 <212> PRT <213> Canis familiaris <400> 936

Met 1 Glu Leu Glu Asn Asp Thr Arg Ile Ser Glu Phe Leu Leu Leu Gly 5 10 15 Phe Ser Glu Lys Pro Glu Leu Gln Pro Phe Leu Phe Gly Leu Phe Leu 20 25 30 Ser Leu Tyr Leu Val Thr Ile Phe Gly Asn Leu Leu Ile Ile Leu Val 35 40 45 Phe Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Leu Leu Val Asn Ile Gln Thr Gln Arg Lys Val Ile Thr Tyr Lys Ser 85 90 95 Cys Ile Met Gln Met Tyr Phe Phe Ile Leu Phe Ile Gly Leu Asp Asn 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Met Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Ala Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Ile Ser Ala Leu His Ser Leu Leu Glu Ser 145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Thr Ala Leu Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr

Page 1051

180

069269_0225_SL.TXT 185 190

Phe Leu Asn Asp Leu Val Met Tyr Cys Ala Thr Val Leu Leu Val Gly 195 200 205

Ala Pro Leu Ala Gly Val Leu Tyr Ser Tyr Ser Lys Ile Leu Ser Ser 210 215 220

Ile Arg Gly Ile Ser Ser Ala Gln Gly Lys His Lys Ala Phe Ser Thr 225 230 235 240

Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Gly Leu 245 250 255

Gly Val Tyr Leu Ser Ser Asp Ala Pro Gln Ser Ser His Ser Ser Ala 260 265 270

Ala Ala Ser Met Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285

Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Glu Ala Leu Thr Val Phe 290 295 300

Phe Arg Gly Lys Pro 305 <210> 937 <211> 954 <212> DNA <213> Canis familiaris <400> 937

atggaacgag gaaatgatac acaaatttca gaattccttc ttctgggatt attagaagaa 60 ccagaactgc agcccctcct atttgggctt ttcctctcca tgtacctcat cactgtcttt 120 ggaaacttgc tcatcatctt ggctgttggt tctgactctc acctccacac ccctatgtac 180 ttcttccttg ccaacctgtc ttttgtagac atctgtttca cttccaccac catccccaag 240 atgcttcaga acacccagac tcagagcaaa gtcatcacct ataagggttg cattacgcag 300 atttattttc tcatagtctt tgccgtgttg gatgtccttc tcttgagtgt gatggcctat 360

Page 1052

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gaccgctatg tggccatctg ttaccctctg cactacacgg tcatcatgaa tccccggctc 420 tgtggtctgc ttgttctggt gtcctggatc atgtgtatct tgaactcctt gttacaaagt 480 ttaatgatgt tgcggctttc cttctgtaca cacttccaaa tcccccactt tttctgtgaa 540 ctcaatcaga tgatccaact tgcctgttct gacacctttc ttaataacat ggtgatgtat 600 tttgcagctg tcttgctggc tggtggtccc ttcattggga tcctttactc ttactctaag 660 atagtttcct ccatacttgg gatctcatca gctcagggaa agtataaagc attttccacc 720 tgtgcatctc acctctcggt tgtctgttta ttttattgta cgatgcttgg tgtgtacctt 780 agctctgctg ctacccacag ctctcactca agtgcagtgg cctcggtgat gtacacagtg 840 atcacaccca tgctgaatcc cttcatctac agcctgagga acagagacat aaagagggct 900 ctgaaaacat tctttgtgaa ggagactcca cgtggccaat tgtcaaaaga ctga 954

<210> 938 <211> 317 <212> PRT <213> Canis familiaris <400> 938

Met Glu 1 Arg Gly Asn 5 Asp Thr Gln Ile Ser Glu Phe Leu Leu Leu Gly 10 15 Leu Leu Glu Glu Pro Glu Leu Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Gly Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Gln Asn Thr Gln Thr Gln Ser Lys Val Ile Thr Tyr Lys Gly 85 90 95

Page 1053

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Cys Ile Thr Gln 100 Ile Tyr Phe Leu Ile Val Phe Ala Val Leu Asp Val 105 110 Leu Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Tyr 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Met Cys Ile Leu Asn Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Met Leu Arg Leu Ser Phe Cys Thr His Phe Gln Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Met Val Met Tyr Phe Ala Ala Val Leu Leu Ala Gly 195 200 205 Gly Pro Phe Ile Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Leu Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Cys Leu Phe Tyr Cys Thr Met Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr His Ser Ser His Ser Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Lys Thr Phe 290 295 300

Page 1054

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Phe Val Lys Glu Thr Pro Arg Gly Gln Leu Ser Lys Asp 305 310 315 <210> 939 <211> 933 <212> DNA <213> Canis familiaris <400> 939 atgcaaccag aaaatgatac atgggtatca gaattctttc ttctgggatt atcagaggaa 60 ccagaacttc agtccatcat atttgggctt ttcctctcca tgtacctgat cacagtcttt 120 ggaaacctgc tcatcatcct ggccatcagc tctgactccc atctccacac tcccatgtac 180 ttctttcttg ccaacctgtc ctttgctgac atctgtgtca cctccaccac cgtcccaaag 240 atgctgctga acgtccagac tcagagccaa gtcatcacct atgcaggttg catcacacag 300 atgcactttt tcataatctt ctcagggttg gacatctatc tcctggctgt gatggcctat 360 gaccgttttg tggccatctg tcatcccctg cagtacatgg tcatcatgaa cccccggctc 420 tgtggactgt tgcttttggt gtcctggatt acaaatgtct tgcattcctt gttacagacc 480 tcaattgtgt tgcagctgtc cttctgtaga aaggcagaaa tctcccactt tttttgtgaa 540 ctcaatcaga tgatccaact tgcctgttct gacagctttc tctataacat ggtgatgtat 600 tttgtagctg tcctgctggg tgggggcccc ctccctggta tcctttactc ttattccagg 660 atagtttcct ccatagttgg gatctcatca gctcagggca agtataaagc attttccacc 720 tgtgcatctc acctgtcagt tgtctcctta tttttttgtt ctggtcttgg agtgtacctc 780 agctctgctg ctccccagaa ctcccacacg agtgcagtgg cctcagtgat gtacacagtg 840 gtcacaccca tgctgaaccc cttcatctac agcctgagga acagagacat aaagagggct 900 ctgaaaagag tcactggggt tccagtgatg taa 933 <210> 940 <211> 310 <212> PRT <213> Canis familiaris <400> 940

Met Gln Pro Glu Asn Asp Thr Trp Val Ser Glu Phe Phe Leu Leu Gly 1 5 10 15

Page 1055

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Leu Ser Glu Glu 20 Pro Glu Leu Gln Ser Ile Ile Phe Gly Leu Phe Leu 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Ala Asp Ile Cys Val Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Val Gln Thr Gln Ser Gln Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Met His Phe Phe Ile Ile Phe Ser Gly Leu Asp Ile 100 105 110 Tyr Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Gln Tyr Met Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Leu Leu Val Ser Trp Ile Thr Asn Val Leu His Ser Leu Leu Gln Thr 145 150 155 160 Ser Ile Val Leu Gln Leu Ser Phe Cys Arg Lys Ala Glu Ile Ser His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Ser 180 185 190 Phe Leu Tyr Asn Met Val Met Tyr Phe Val Ala Val Leu Leu Gly Gly 195 200 205 Gly Pro Leu Pro Gly Ile Leu Tyr Ser Tyr Ser Arg Ile Val Ser Ser 210 215 220

Page 1056

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Ile Val 225 Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Phe Cys Ser Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Pro Gln Asn Ser His Thr Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Lys Arg Val 290 295 300 Thr Gly Val Pro Val Met

305 310 <210> 941 <211> 969 <212> DNA <213> Canis familiaris <400> 941

atggaaccag ggaaccttac aggagattca gagtttcttc ttttgggatt ttcagaggaa 60 ctagaactac agccactcgt atttgggctt tttctctcca tgtacctgat cactgtgttt 120 ggaaacctgc tcctcatcct ggctgtcagc tctgactccc accttcacac tcccatgtac 180 ttcttcctca ccaacctgtc ctttgtggac atctgtttca cctccaccac cgtccccaag 240 atgctatgga acatccagac tcagagcaaa gtcatcactt atgaaggctg tatcagccag 300 atatactttt ttatactctt tgcaggatta gatgtccttc tactgactgt gatggcctat 360 gacaggtttg tggccatctg tcaccctctg cactacatgg tcatcatgaa tccacagctg 420 tgtgggcaat tggttctgat gtcatggatt ataagcatcc tccattcctt gttagaaagc 480 ttaatggtct tgcggctgtc cttctgtaca aagttggaaa tccctcattt tttctgtgaa 540 ctcaatcaga tgatccaact tgcctgttct gacacctttc tcaataacat ggtgatgtat 600 tttgcagctg tcttgttggc tggtggtccc tttgttggga ttcttttctc ttactctaag 660

Page 1057

069269_0225_SL.TXT atagtttcct ccatacatag aatctcatca gctcagggca agtacaaagc attttccacc tgtgcatctc acctctcagt tgtctcctta ttttattgta caatcctagg agtgtacctt agctctgctg ctacccagag ctcccactca agtgcagtgg cctcagtgat gtacacagtg gtcacaccgc tgatgaaccc tttcatctac agcctgagga acagagacat aaaggaggct ttgatgagat tttctgggat gccagctcta aaaaggccaa tcgttctggg gctgaagaag tgcccatga

720

780

840

900

960

969 <210> 942 <211> 322 <212> PRT <213> Canis familiaris <400> 942

Met Glu Pro Gly Asn Leu Thr Gly Asp Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Glu Glu Leu Glu Leu Gln Pro Leu Val Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Leu Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Gly 85 90 95 Cys Ile Ser Gln Ile Tyr Phe Phe Ile Leu Phe Ala Gly Leu Asp Val 100 105 110 Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125

Page 1058

Pro Leu 130 His Tyr Met Val Ile 135 069269_0225_SL.TXT Met Asn Pro Gln Leu Cys 140 Gly Gln Leu Val Leu Met Ser Trp Ile Ile Ser Ile Leu His Ser Leu Leu Glu Ser 145 150 155 160 Leu Met Val Leu Arg Leu Ser Phe Cys Thr Lys Leu Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Met Val Met Tyr Phe Ala Ala Val Leu Leu Ala Gly 195 200 205 Gly Pro Phe Val Gly Ile Leu Phe Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile His Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Ile Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Leu Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Glu Ala Leu Met Arg Phe 290 295 300 Ser Gly Met Pro Ala Leu Lys Arg Pro Ile Val Leu Gly Leu Lys Lys 305 310 315 320

Cys Pro

Page 1059

069269_0225_SL.TXT <210> 943 <211> 306 <212> DNA <213> Canis familiaris <400> 943 atgggaccag gaaatgatac acaaatttca cgatttcttc ttctgggatt aacaaacaaa 60 ccagaactac agcccctcat atttgggatt ttcctctcca tttacctgat tactgtgttt 120 ggaaacctac tcatcatctt ggctgtcagc tctgactccc acctccacac ccccatgtac 180 ttcttcctct ccaacctctc ctttgtagac atctgtgtca cctccaccat cgtcccaaag 240 atgctggtga atatacagac acggaacaaa attataactt atgcaggctg catcagccag 300 atcttt

306 <210> 944 <211> 102 <212> PRT <213> Canis familiaris <400> 944

Met Gly Pro Gly Asn Asp Thr Gln Ile Ser 1 5 10 Leu Thr Asn Lys Pro Glu Leu Gln Pro Leu 20 25 Ser Ile Tyr Leu Ile Thr Val Phe Gly Asn 35 40 Val Ser Ser Asp Ser His Leu His Thr Pro 50 55 Asn Leu Ser Phe Val Asp Ile Cys Val Thr 65 70 Met Leu Val Asn Ile Gln Thr Arg Asn Lys 85 90 Cys Ile Ser Gln Ile Phe

Arg Phe Leu Leu Leu 15 Gly Ile Phe Gly Ile 30 Phe Leu Leu Leu Ile 45 Ile Leu Ala Met Tyr 60 Phe Phe Leu Ser Ser 75 Thr Ile Val Pro Lys 80 Ile Ile Thr Tyr Ala 95 Gly

100

Page 1060

069269_0225_SL.TXT <210> 945 <211> 651 <212> DNA <213> Canis familiaris <400> 945

ttatttgcag gctgggatga ctttctcttg gctgtgatgg cctatgaccg ctacgtggcc 60 atctgtcacc ccctgcacta cacggtcatc atgaaccccc agctctgtgg actgcttgtt 120 ctggtgtcct ggatcatgag tgtcctgaat tccttattac aaagcttaat gatattgagg 180 ctgtccttct gtagagaagt ggaaataccc cactttttct gtgaacttca tcagatgatc 240 caacttgcct gttctgatac atttcttaat gacatggtgc tgtattttgc agctgtgctg 300 ctggctggtg gtccccttgc tgggatcctt tattcatatt ctaagattat tttctccata 360 catagaatct catcagctca gggcaaatat aaagcatttt ctacctgtgc atctcacctc 420 tcagttgtct ccttatttta ttgcacggtc ctgggagtgt atcttagctc tgctgctacc 480 cagaactacc agacaagtgc agtggcctcg gtgatgtaca cagtggtcac acccatgctg 540 aaccccttca tctacagcct gaggaacaga gatataaaga gggctctgat gaggtttttc 600 agaaggacag ctctaaaagg gacaattgtc ctggtatcaa agaaatgccc t 651

<210> 946 <211> 217 <212> PRT <213> Canis familiaris <400> 946

Leu Phe Ala Gly Trp Asp Asp Phe Leu Leu Ala Val Met Ala Tyr Asp 1 5 10 15 Arg Tyr Val Ala Ile Cys His Pro Leu His Tyr Thr Val Ile Met Asn 20 25 30 Pro Gln Leu Cys Gly Leu Leu Val Leu Val Ser Trp Ile Met Ser Val 35 40 45 Leu Asn Ser Leu Leu Gln Ser Leu Met Ile Leu Arg Leu Ser Phe Cys 50 55 60

Page 1061

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Arg Glu Val Glu Ile Pro His Phe Phe Cys Glu Leu His Gln Met Ile 65 70 75 80 Gln Leu Ala Cys Ser Asp Thr Phe Leu Asn Asp Met Val Leu Tyr Phe 85 90 95 Ala Ala Val Leu Leu Ala Gly Gly Pro Leu Ala Gly Ile Leu Tyr Ser 100 105 110 Tyr Ser Lys Ile Ile Phe Ser Ile His Arg Ile Ser Ser Ala Gln Gly 115 120 125 Lys Tyr Lys Ala Phe Ser Thr Cys Ala Ser His Leu Ser Val Val Ser 130 135 140 Leu Phe Tyr Cys Thr Val Leu Gly Val Tyr Leu Ser Ser Ala Ala Thr 145 150 155 160 Gln Asn Tyr Gln Thr Ser Ala Val Ala Ser Val Met Tyr Thr Val Val 165 170 175 Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Arg Asp Ile 180 185 190 Lys Arg Ala Leu Met Arg Phe Phe Arg Arg Thr Ala Leu Lys Gly Thr 195 200 205 Ile Val Leu Val Ser Lys Lys Cys Pro 210 215 <210> 947 <211> 807 <212> DNA <213> Canis familiaris <400> 947 atgagggaat caaatcagtc agtgacctca gacttcaccc tcatggtgct cttcagccac tcagggccac atgtggttct attcttcctt gtgactgtca tattcactat gggccttctg ggcaatgcca tcctgctctt cctgatccat acagactcca ggctccacac acccatgtac

120

180

Page 1062

069269_0225_SL.TXT

ttcctgctca gtcaactctc cctattggat gttggctttc ccttggtcac catccccaag 240 atggcagctg acttcctgca gggagagggc tccatctcct ttggagattg tgcagctcag 300 atgttcttcc tgatgctact gggtgtctct gagggtgtcc tactatccct tatgtcttac 360 gaccgctatg ttgctgtgtg tcaccccctg cattatcttg tgttcatgag gcgtcaggtc 420 tgtctgctca tggtgggcac ctcctggttg tcaggtgtgc ttgtggcctc catccagacc 480 tccatcaccc tgcacttccc ctactgtgcc tcacacactg tggatcactt cttctgtgag 540 ttgcctgctc tgttgaagct ctcttgtgca gacacctctg cttatgagct gtcgctatcc 600 atctcagggg tgctgatcct gctactgccc ctgtcactca tcaccacctc ttacagccat 660 gtgttgaggg ctgttctccg catgcagtct gctgaggccc gacacaaggc cttcaccacc 720 tgctcctcgc acatcactgt ggtggggctc ttttatgggg cagcctattc atgtacatgg 780 ttccaggtac ctaccacagc ccacaac 807

<210> 948 <211> 269 <212> PRT <213> Canis familiaris <400> 948

Met Arg Glu Ser Asn Gln Ser Val Thr Ser Asp Phe Thr Leu Met Val 1 5 10 15 Leu Phe Ser His Ser Gly Pro His Val Val Leu Phe Phe Leu Val Thr 20 25 30 Val Ile Phe Thr Met Gly Leu Leu Gly Asn Ala Ile Leu Leu Phe Leu 35 40 45 Ile His Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Leu Asp Val Gly Phe Pro Leu Val Thr Ile Pro Lys 65 70 75 80 Met Ala Ala Asp Phe Leu Gln Gly Glu Gly Ser Ile Ser Phe Gly Asp 85 90 95

Page 1063

069269_0225_SL.TXT

Cys Ala Ala Gln Met Phe Phe Leu Met Leu Leu Gly Val Ser Glu Gly 110 100 105 Val Leu Leu Ser Leu Met Ser Tyr Asp Arg Tyr Val Ala Val Cys His 115 120 125 Pro Leu His Tyr Leu Val Phe Met Arg Arg Gln Val Cys Leu Leu Met 130 135 140 Val Gly Thr Ser Trp Leu Ser Gly Val Leu Val Ala Ser Ile Gln Thr 145 150 155 160 Ser Ile Thr Leu His Phe Pro Tyr Cys Ala Ser His Thr Val Asp His 165 170 175 Phe Phe Cys Glu Leu Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr 180 185 190 Ser Ala Tyr Glu Leu Ser Leu Ser Ile Ser Gly Val Leu Ile Leu Leu 195 200 205 Leu Pro Leu Ser Leu Ile Thr Thr Ser Tyr Ser His Val Leu Arg Ala 210 215 220 Val Leu Arg Met Gln Ser Ala Glu Ala Arg His Lys Ala Phe Thr Thr 225 230 235 240 Cys Ser Ser His Ile Thr Val Val Gly Leu Phe Tyr Gly Ala Ala Tyr 245 250 255 Ser Cys Thr Trp Phe Gln Val Pro Thr Thr Ala His Asn 260 265

<210> 949 <211> 960 <212> DNA <213> Canis familiaris <400> 949 atggctgcca ccttgggcct aaaccacagc tctgtgtctg aattcatcct cgtgggcttc

Page 1064

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tccaccttcc cgccccatct cctgcctgcc ttcttcctgc tgttcctgct catgtacctg 120 ttcacgctgc tggggaacct gctcatcatg gccactgtct ggagcgagcg cggcctgcac 180 acgcccatgt acctcttcct gtgcgccctg tccatctccg agatcctcta caccttggcc 240 atcaccccgc gcctgctggc tgacctgctc tccacccgcc gcaccatcgc ctttgcagcc 300 tgtaccagcc agatgttctt ctctttcacg ttcggcttca cccactcctt cctgctcacg 360 gtcatgggct acgaccgcta tgtggccatc tgccaccctc tgcgctacaa tgtgctcatg 420 agcccccgtg gctgcaccta cctggtggcc tggtcctggg ctggtggctc gatcataggg 480 ctggtggtgg ccacagctgt tttccacctc actttctgtg gacccaatga gatccaccat 540 tttttatgtc atgtgccccc tctcttgaag ctggcctgtg gaactgatgt accaatagtg 600 gccctgggcg tggggctggt gtgcatcacc gccctgctgg gctgctttct cctcatcctc 660 ctctcctatg cctttatcgt ggctgccatc ttgaggatcc cctctgctga gggaaggcac 720 aaagccttct ccacctgtgc gtcccacctt atagtggtca ttgtgcacta tggctttgcc 780 tctgttatct acctcaagcc caagggtctg cactcccagg aaggcaacac cttgatggcc 840 atcacctata cggtcctcac gcccttcctc agccccatca tcttcagtct caggaataag 900 gagctgaaga tcgccatgaa gaagaccttc ctcagtaaac tctatccctc cagcatctaa 960

<210> 950 <211> 319 <212> PRT <213> Canis familiaris <400> 950

Met Ala Ala Thr Leu Gly Leu Asn His Ser Ser Val Ser Glu Phe Ile 1 5 10 15 Leu Val Gly Phe Ser Thr Phe Pro Pro His Leu Leu Pro Ala Phe Phe 20 25 30 Leu Leu Phe Leu Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu 35 40 45 Ile Met Ala Thr Val Trp Ser Glu Arg Gly Leu His Thr Pro Met Tyr

50 55 60

Page 1065

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Leu 65 Phe Leu Cys Ala Leu Ser Ile Ser Glu Ile Leu Tyr Thr Leu Ala 70 75 80 Ile Thr Pro Arg Leu Leu Ala Asp Leu Leu Ser Thr Arg Arg Thr Ile 85 90 95 Ala Phe Ala Ala Cys Thr Ser Gln Met Phe Phe Ser Phe Thr Phe Gly 100 105 110 Phe Thr His Ser Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly 130 135 140 Cys Thr Tyr Leu Val Ala Trp Ser Trp Ala Gly Gly Ser Ile Ile Gly 145 150 155 160 Leu Val Val Ala Thr Ala Val Phe His Leu Thr Phe Cys Gly Pro Asn 165 170 175 Glu Ile His His Phe Leu Cys His Val Pro Pro Leu Leu Lys Leu Ala 180 185 190 Cys Gly Thr Asp Val Pro Ile Val Ala Leu Gly Val Gly Leu Val Cys 195 200 205 Ile Thr Ala Leu Leu Gly Cys Phe Leu Leu Ile Leu Leu Ser Tyr Ala 210 215 220 Phe Ile Val Ala Ala Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His 225 230 235 240 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Ile Val Val Ile Val His 245 250 255 Tyr Gly Phe Ala Ser Val Ile Tyr Leu Lys Pro Lys Gly Leu His Ser 260 265 270

Page 1066

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Gln Glu Gly 275 Asn Thr Leu Met Ala Ile Thr Tyr Thr Val Leu Thr Pro 280 285 Phe Leu Ser Pro Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Ile 290 295 300 Ala Met Lys Lys Thr Phe Leu Ser Lys Leu Tyr Pro Ser Ser Ile 305 310 315

<210> 951 <211> 969 <212> DNA <213> Canis familiaris <400> 951

atggaaaaag gaaatgatac acaaatttca gcatttcttc ttctgggatt atcagaggaa 60 ccagaaatac agccccttct atttgggctt ttcctctcca tgtacctcat cactgtgttt 120 ggaaacctgc tcctcatcct ggccatcagc tctgactctc atctccacac tcctatgtac 180 ttcttccttg ccaacctgtc ctttgtagac atctgtttca cctccaccac tgtccccaag 240 atgcttcaga acatccagac tcacagcaaa gtcattacct atgcaggctg catcacacag 300 atgtactttt tcatactctt tgttgtattg gatgcctttc tcctgactgt gatggcctat 360 gaccggcatg tggccatctg tcaaccactg cactacatgg tcattatgaa aacccagctg 420 tgtgcactgc tggttctgct gtcctggatt gtgagtgtct tgtattcctt gttacaaacc 480 tccatggtgt tgcggctgtc cttctgtaca gagatggcaa tccctcactt tttctgtgaa 540 ctcaatcaag tgatccaact tgcctgttct gatacctttc tcagtaacat ggtgatgtat 600 tttgcagcta tgtttatggc tactggtacc ttctttggga tcctttactc ttactctaag 660 attgcttcct ccatacatag aatatcatca gccctgggca aatccaaagc attttccacc 720 tgtgcatctc acctctcagt tgtctcctta tttttttgta caagtttagg agtgtacctt 780 agctctgctg ctccccagag ctctcactca actgcagtgg cctctgtgat gtacacagtt 840 gtcacaccca tgctgaaccc cttcatctat agtctgagga acaaagacat aaaaaaggct 900 ctgatgagat tctctgggat ggcaggtcta aaagtgacaa caatcctgga gttgaagaac 960

Page 1067

069269_0225_SL.TXT cacccatga

969 <210> 952 <211> 322 <212> PRT <213> Canis familiaris <400> 952

Met 1 Glu Lys Gly Asn 5 Asp Thr Gln Ile Ser Ala Phe Leu Leu Leu Gly 10 15 Leu Ser Glu Glu Pro Glu Ile Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Leu Ile Leu Ala 35 40 45 Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Gln Asn Ile Gln Thr His Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Ile Leu Phe Val Val Leu Asp Ala 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg His Val Ala Ile Cys Gln 115 120 125 Pro Leu His Tyr Met Val Ile Met Lys Thr Gln Leu Cys Ala Leu Leu 130 135 140 Val Leu Leu Ser Trp Ile Val Ser Val Leu Tyr Ser Leu Leu Gln Thr 145 150 155 160 Ser Met Val Leu Arg Leu Ser Phe Cys Thr Glu Met Ala Ile Pro His 165 170 175

Page 1068

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Phe Phe Cys Glu Leu Asn Gln Val Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Ser Asn Met Val Met Tyr Phe Ala Ala Met Phe Met Ala Thr 195 200 205 Gly Thr Phe Phe Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Ala Ser Ser 210 215 220 Ile His Arg Ile Ser Ser Ala Leu Gly Lys Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Phe Cys Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Pro Gln Ser Ser His Ser Thr Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Lys Ala Leu Met Arg Phe 290 295 300 Ser Gly Met Ala Gly Leu Lys Val Thr Thr Ile Leu Glu Leu Lys Asn 305 310 315 320

His Pro <210> 953 <211> 933 <212> DNA <213> Canis familiaris <400> 953 atggaacaag gaaattatac acaaatttca gcatttcttc ttctgggatt atcagaggaa ccagacctgc agcccctcct atttgggctt ttcctctcca tgtacctcat cactgtgttt ggaaacctgt tcatcatcct ggctgtcagt tctgactctc acctccacac acccatgtac Page 1069

120

180

069269_0225_SL.TXT ttcttcttgg ccaacctgtc atgcttcaga acatccagac atatactttt tcctactctt gacaggtttc tggccatctg tgtgtactac tggttctggt ctaatggtgt tgtggctgtc atcaatcagg tggtccaact tttgcagctg gattgttggg atagtctctt cgatacatag tgtgcatctc acctttctgt agctctgctg ctccccagag gtcacaccta tgctaaaccc ctgaaaagaa tcattggggc <210> 954 <211> 310 <212> PRT <213> Canis familiaris <400> 954 ctttgtagac atctgtttca tcagagcaaa gtcatcacct ggctggattg gacaactttc tcaccccttg cactatacag ggcctggatg atgagtgcct cttctgtaga gaggtgaaag tgcttgttct gacaactttc tggttcttcc ttagctggga aatctcatct gctcagggaa tgtctcctta ttttattgta ctcccactca agtgcagtgg cttcatctac agcctgagga tccagtgata taa cctctaccac tgtccccaag atgaaggttg catcactcag tcctggctgt gatggcttat tcatcatgaa accccagcta tgaattcctt attacaaagc tctcccactt tttctgtgag ttaatgacaa ggtgatgcat tcctttactc ttactctaag agtataaagc attttccact caattctggg agtgtacctt cctcggtgat gtacacagtg acagagacat aaagagggct

240

300

360

420

480

540

600

660

720

780

840

900

933

Met 1 Glu Gln Gly Asn 5 Tyr Leu Ser Glu Glu 20 Pro Asp Ser Met Tyr 35 Leu Ile Thr Val Ser 50 Ser Asp Ser His Asn 65 Leu Ser Phe Val Asp 70

Thr Gln Ile Ser 10 Ala Leu Gln Pro 25 Leu Leu Val Phe 40 Gly Asn Leu Leu 55 His Thr Pro Met Ile Cys Phe Thr Ser

Phe Leu Leu Leu 15 Gly Phe Gly Leu 30 Phe Leu Phe Ile 45 Ile Leu Ala Tyr 60 Phe Phe Leu Ala Thr Thr Val Pro Lys 80

Page 1070

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Met Leu Gln Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Gly 85 90 95 Cys Ile Thr Gln Ile Tyr Phe Phe Leu Leu Leu Ala Gly Leu Asp Asn 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Leu Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Lys Pro Gln Leu Cys Val Leu Leu 130 135 140 Val Leu Val Ala Trp Met Met Ser Ala Leu Asn Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Val Leu Trp Leu Ser Phe Cys Arg Glu Val Lys Val Ser His 165 170 175 Phe Phe Cys Glu Ile Asn Gln Val Val Gln Leu Ala Cys Ser Asp Asn 180 185 190 Phe Leu Asn Asp Lys Val Met His Phe Ala Ala Gly Leu Leu Gly Gly 195 200 205 Ser Ser Leu Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile His Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Ile Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Pro Gln Ser Ser His Ser Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285

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069269_0225_SL.TXT

Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Lys Arg Ile 290 295 300

Ile Gly Ala Pro Val Ile

305 310 <210> 955 <211> 933 <212> DNA <213> Canis familiaris <400> 955

atggaactga gcaatgatac aaaaatttca gagtttcttc ttcttggatt ttcagaggaa 60 ccagaactgc agcccctcat atttgggttt ttcctttcca tgtacctgat cactgtgttt 120 ggaaacttgc tcatcatcct ggctgtcagc tcagactccc accttcacac ccccatgtac 180 ttcttcctaa ccaatctgtc ctttgtagac atctgtttca cctccaccac catgcccaag 240 atgctccaga acatgaggac ccagagcaag gtcattagct ttgcaggttg catcagtcag 300 atgtattttt tcctactctg tgccttgttg gatgattttg tcttgtctgt aatggcttat 360 gaccgcttcg tggccatctg tcaccccttg cgctacacag tcatcatgaa cccccagatc 420 tgtggactgc tggttctggt gtcctggatc atcagtgttc tcaattccat gacacagagc 480 ttaatggtgt tgcagctgtc cttctgtaca gacatggaaa tccaccattt tttctgtgaa 540 ctcaatcaga tagttgggaa tgcctgttct gacacctttc ttaatgacat ggtgatgtat 600 cttgcaattg tgctgctggg gggtgtcccc ctggctggta taatgtactc ttactctaag 660 atagtttcca ccatatgtag aatatcgtca gctcagggca agtataaagc attttccact 720 tgtgcatctc acctctcagt tgtctcctta ttttatggta caagcctagg agtgtacctt 780 agctctgctg ctcccctaaa ctctcactct agtgcagtag cctctgtgat gtacacagtg 840 gtcacaccca tgctgaaccc tttcatctac agtctgagga acagagacat aaagagggct 900 ctgaaaagaa tcattgggat tccagtgatg taa 933

<210> 956 <211> 310 <212> PRT

Page 1072

069269_0225_SL.TXT <213> Canis familiaris <400> 956

Met Glu Leu Ser Asn Asp Thr Lys Ile Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Glu Glu Pro Glu Leu Gln Pro Leu Ile Phe Gly Phe Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Met Pro Lys 65 70 75 80 Met Leu Gln Asn Met Arg Thr Gln Ser Lys Val Ile Ser Phe Ala Gly 85 90 95 Cys Ile Ser Gln Met Tyr Phe Phe Leu Leu Cys Ala Leu Leu Asp Asp 100 105 110 Phe Val Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Pro Gln Ile Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Ile Ser Val Leu Asn Ser Met Thr Gln Ser 145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Thr Asp Met Glu Ile His His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Ile Val Gly Asn Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asp Met Val Met Tyr Leu Ala Ile Val Leu Leu Gly Gly

Page 1073

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195 200 205 Val Pro Leu Ala Gly Ile Met Tyr Ser Tyr Ser Lys Ile Val Ser Thr 210 215 220 Ile Cys Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Pro Leu Asn Ser His Ser Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Lys Arg Ile 290 295 300 Ile Gly Ile Pro Val Met 305 310

<210> 957 <211> 933 <212> DNA <213> Canis familiaris <400> 957

atggaagcag acaatgatac aggaatttca gagtttcttc ttctgggatt atcagaggag 60 ccagaactac agcccctcct atttgggatg ttcctctcca tgtacctgat cactgtcttt 120 ggaaacctgc tcatcattct ggctgtcagg tcagaccccc acctccacac ccccatgtac 180 ttcttcctcg ccaacctgtc ctttgtagac atctgtttca cctccaccac tgtcccgaag 240 atgctgctga acatacagac tcagggcaaa gtcatcacct atgcaggctg catcacacag 300 atatactttt ttctactttt tgcagactgg gatgactttc tcctggctgt gatggcctat 360 gaccgttttt tggctatctg tcaccccttg cgctatacag tcatcatgga tccgtggctc 420 tgtggactgc tggttctggt gtcgtggatc atgagtaccc tgaattcctt attacagagc 480

Page 1074

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ttaatggtgt tgcggctgtc cttctgtgca gaggtggaaa tcccccattt tttctgtgaa 540 ctcaatcagg tggttgggca tgcctgttct gacacctttt taaataacat agtgatatat 600 tttgcagccg tgctgctggg tggggctccc ctgactggta tcatatactc ttactctaag 660 atagtttcct caatacttag gatctcagca gctcagggca aatataaagc attttccacc 720 tgtgcatctc acctctcagt tgtctcctta ttttatggta caagcctagg agtgtacctg 780 agttctgctg ctaatcacag ctcttacaaa agtgcagtag cctcggtgat gtacacggtg 840 gtcacaccca tgctgaatcc cttcatctac agcctaagga acagagacat aaagagggct 900 ctgagaagaa ttactggggt tccagtgata taa 933

<210> 958 <211> 310 <212> PRT <213> Canis familiaris <400> 958

Met Glu Ala Asp Asn Asp Thr Gly Ile Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Ser Glu Glu Pro Glu Leu Gln Pro Leu Leu Phe Gly Met Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Arg Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Gly Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Ile Tyr Phe Phe Leu Leu Phe Ala Asp Trp Asp Asp 100 105 110

Page 1075

Phe Leu Leu 115 Ala Val Met Ala 069269_0225_SL.TXT Tyr Asp Arg Phe Leu Ala 120 125 Ile Cys His Pro Leu Arg Tyr Thr Val Ile Met Asp Pro Trp Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Met Ser Thr Leu Asn Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Val Leu Arg Leu Ser Phe Cys Ala Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Val Val Gly His Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Ile Val Ile Tyr Phe Ala Ala Val Leu Leu Gly Gly 195 200 205 Ala Pro Leu Thr Gly Ile Ile Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Leu Arg Ile Ser Ala Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Asn His Ser Ser Tyr Lys Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Arg Arg Ile 290 295 300 Thr Gly Val Pro Val Ile 305 310

Page 1076

069269_0225_SL.TXT <210> 959 <211> 933 <212> DNA <213> Canis familiaris <400> 959

atgaaaccag gaaatgatac gcaaatttca gaatttcttc ttctgggatt atcagaggaa 60 ccagaactgc agcccctcat ctttggcttt ttcctctcca tgtacctcat cactgtgttt 120 ggaaacctgc tcatcatcct ggctgtcagc tctgattccc acctccacac cccaatgtac 180 ttcttcctgg ccaacctttc ctttgtggac atctgtttca cctccaccac cgtccccaag 240 atgctatgga acatccagac tcagagcaaa gttatcacct atgcaggctg catcacacag 300 atttactttc tcatagtctt tgctgtgttg gatgtctttc tcctgagcat gatggcctat 360 gaccggtatg tggccatctg tcaccccctg caatacacag tcatcatgaa ccctcgggtc 420 tgtggacttc tggttctggt gtcctggatc atctgtgtcc tgcagtcctt gttacaaacc 480 tcgatggtgt tgcggctgtc cttctgtgca gtggtcgaaa tcccccactt ttcctgtgaa 540 cttaatcaga tgatccaagt tgcctgttct gacaccttcc ttaataactt gatggtgtat 600 tttgcagctg tcctgctggt tggtggttcc cttgctggga tactttactc ttactctagg 660 atagtttcct ccatacttgg gatctcatca gctcggggca agtataaagc attctccacc 720 tgtgcatctc acctctcagt tgtctgctta tttttttgta caagcctagg agtatacctt 780 agctctgctg tttcccagag ctcccactca actgcagtgg cctcagtgat gtacacagtg 840 gtcacaccta tgctaaaccc cttcatctac agcctgagga acaaagacat aaagagggct 900 ctgaaaagaa ccgttgggat tccagtgatg taa 933

<210> 960 <211> 310 <212> PRT <213> Canis familiaris <400> 960

Met 1 Lys Pro Gly Asn 5 Asp Thr Gln Ile Ser Glu Phe Leu Leu Leu Gly 10 15 Leu Ser Glu Glu Pro Glu Leu Gln Pro Leu Ile Phe Gly Phe Phe Leu 20 25 30

Page 1077

069269_0225_SL.TXT

Ser Met Tyr 35 Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Ile Tyr Phe Leu Ile Val Phe Ala Val Leu Asp Val 100 105 110 Phe Leu Leu Ser Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Gln Tyr Thr Val Ile Met Asn Pro Arg Val Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Ile Cys Val Leu Gln Ser Leu Leu Gln Thr 145 150 155 160 Ser Met Val Leu Arg Leu Ser Phe Cys Ala Val Val Glu Ile Pro His 165 170 175 Phe Ser Cys Glu Leu Asn Gln Met Ile Gln Val Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Leu Met Val Tyr Phe Ala Ala Val Leu Leu Val Gly 195 200 205 Gly Ser Leu Ala Gly Ile Leu Tyr Ser Tyr Ser Arg Ile Val Ser Ser 210 215 220 Ile Leu Gly Ile Ser Ser Ala Arg Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240

Page 1078

069269_0225_SL.TXT

Cys Ala Ser His Leu Ser Val 245 Val Cys Leu Phe Phe Cys Thr Ser Leu 250 255 Gly Val Tyr Leu Ser Ser Ala Val Ser Gln Ser Ser His Ser Thr Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Arg Ala Leu Lys Arg Thr 290 295 300 Val Gly Ile Pro Val Met

305 310 <210> 961 <211> 969 <212> DNA <213> Canis familiaris <400> 961

atgcaaccaa acaatgatac atggatatca gaattctttc ttctgggatt ttcagaggga 60 ccagactggc agccactcgt atttgggctt ttcctctcca tgtacctgat cactgtgttt 120 ggaaacctgc tcatcatcct ggccatcagc tctgactccc acctccacac ccccatgtac 180 ttcttcctcg ccaacctgtc ctttgtagac atctgtttca cctctaccac tgtccccaag 240 atgctgctga acatccagac tcagagcaaa gtcatcacct atgcaggctg catcacacag 300 atgtactttt tcataatctt ttcagggttg gacatctatc tcctggctgt gatggcttat 360 gaccgttttg tggccatctg ccatcccctg cactacatgg tcatcatgaa cccccggctc 420 tgtggactgc tagttctggt gtcctggatc ataagtgtct tgcactcctt tttacagacc 480 tcaatggtgt tgcagctgtc cttctgtaca gaggtggaaa tcccgcactt tttctgtgaa 540 ctcaatcaca tgatccaact tgcctgttct gacatatttc ttaataacat gatgatatac 600 tttgcagctg tgctcctggg gggtgttccc ctggctgggg tcctttactc ctactctaag 660 atagtttcct gcatacatag aatatcatca gctcagggta agcataaagc attttccacc 720 tgtgcatctc acctctcagt tgtctcttta ttttattgta cagccctagg agtgtacctt 780

Page 1079

069269_0225_SL.TXT agctctgctg ctccccagag ctcctacaca agtgcagtgg cctcagtgat gtacacagtg gtcacaccta tgctgaaccc cttcatctac agcctgagga acagaaacat aaagagggct ctgatgaaat tctctgggct ggaagctatc aaaaggccag ttgtcctatt gctgaagaat ttcccataa

840

900

960

969 <210> 962 <211> 322 <212> PRT <213> Canis familiaris <400> 962

Met Gln 1 Pro Asn Asn 5 Asp Thr Trp Ile Ser Glu Phe Phe Leu Leu Gly 10 15 Phe Ser Glu Gly Pro Asp Trp Gln Pro Leu Val Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Ile Ile Phe Ser Gly Leu Asp Ile 100 105 110 Tyr Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Met Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140

Page 1080

Val 145 Leu Val Ser Trp Ile 150 Ile 069269_0225_SL.TXT Ser Val Leu His Ser Phe 155 Leu Gln Thr 160 Ser Met Val Leu Gln Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn His Met Ile Gln Leu Ala Cys Ser Asp Ile 180 185 190 Phe Leu Asn Asn Met Met Ile Tyr Phe Ala Ala Val Leu Leu Gly Gly 195 200 205 Val Pro Leu Ala Gly Val Leu Tyr Ser Tyr Ser Lys Ile Val Ser Cys 210 215 220 Ile His Arg Ile Ser Ser Ala Gln Gly Lys His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Ala Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Pro Gln Ser Ser Tyr Thr Ser Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asn Ile Lys Arg Ala Leu Met Lys Phe 290 295 300 Ser Gly Leu Glu Ala Ile Lys Arg Pro Val Val Leu Leu Leu Lys Asn 305 310 315 320

Phe Pro <210> 963 <211> 846 <212> DNA <213> Canis familiaris

Page 1081

069269_0225_SL.TXT <400> 963 ccctcctttt tggatttttt tctgtccatg tacctggtaa ctttcattgg gaacctactc 60 atcatcctgg caattatcac tgactcctgc ctccacacgc ccatgtacct cttcctctct 120 aatctctctt ttgcagacat ctgtttcacc tccaccacag tccccaaaat gctgttgaat 180 atccagacac agagaaaatt cattacctat gcagaatata tcacccaggt atatttcttc 240 atgctttttg gagatctgga taacttcctt ctgacggtga tggcttatga ccggtttgtg 300 gccatctgtc accccctaca atatatggtc atgatgaacc cttgggtctg tgggctcctg 360 cttatggcat gctgaattat gactgccctg cagtcattgt cacagagctt aatggtttta 420 cggctctctt tttgtaatga tttggaaatc cctcactttt tctgtgaact taatcaattg 480 gtccaacttg cttgttctga cacctttctc aatgatatag ttatgtattt tgctactgga 540 cttgttggtg ttgttcctct tactggaatt ctcttctctt actctaagat tgtaacctcc 600 attttgagaa tttcatcagc tggaggcaag tatagagcat tttccacatg tgggtctcac 660 ctttcagttg tctccttgtt ctactgcaca ggccttgggg tctacctcag ttctactggt 720 tcacaaaact ccaggacaag tgccatagcc tcagtgatgt atacagtggt cacacccatg 780 ctgaacccct ttatttacag tcttaaaaac aaagacataa agcaatcact taaaaaactc 840 ttcagc 846 <210> 964 <211> 156 <212> PRT <213> Canis familiaris <400> 964

Met Thr Ala Leu Gln Ser Leu Ser Gln Ser Leu Met Val Leu Arg Leu 1 5 10 15 Ser Phe Cys Asn Asp Leu Glu Ile Pro His Phe Phe Cys Glu Leu Asn 20 25 30 Gln Leu Val Gln Leu Ala Cys Ser Asp Thr Phe Leu Asn Asp Ile Val 35 40 45 Met Tyr Phe Ala Thr Gly Leu Val Gly Val Val Pro Leu Thr Gly Ile Page 108 2

069269_0225_SL.TXT

50 55 60

Leu Phe 65 Ser Tyr Ser Lys Ile Val Thr Ser Ile Leu Arg Ile Ser Ser 70 75 80 Ala Gly Gly Lys Tyr Arg Ala Phe Ser Thr Cys Gly Ser His Leu Ser 85 90 95 Val Val Ser Leu Phe Tyr Cys Thr Gly Leu Gly Val Tyr Leu Ser Ser 100 105 110 Thr Gly Ser Gln Asn Ser Arg Thr Ser Ala Ile Ala Ser Val Met Tyr 115 120 125 Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Lys Asn 130 135 140 Lys Asp Ile Lys Gln Ser Leu Lys Lys Leu Phe Ser

145 150 155 <210> 965 <211> 933 <212> DNA <213> Canis familiaris <400> 965 atgcaaccaa acaatgatac atggatatca gaattctttc ttctgggact ttcagaggaa 60 ccagaactgc agcccctcat atttgggctt ttcttctcca tgtacctgat cactgtcttt 120 ggaaacctgc tcatcatctt ggctgtcagc tctgactccc atctccacac ccccatgtac 180 ttcttcctca ccaatctgtc ctttatagac atctgcgtta cctccaccac catcccaaat 240 atagtgataa atatccagac tcagagcaaa gttatcacct atgcaggctg catcacacag 300 atgtactttt tcataatctt ctcaggattg gacatctatc tcctgtctgt gatggcctat 360 gaccgttttg tggccatctg tcaccctctg cagtacatgg taatcatgaa cccccagctc 420 tgtggactgt tgcttctggt ctcctgcatc gcaaatatct tacactcctt gttacagacc 480 tcaattatgt tacagttgtc cttttgtaga gaggtagaaa tctcccactt tttctgtgaa 540 ctcaatcaca tgattcaact tgcatgttct gacacctttc tcaataacat ggtaatgtat 600

Page 1083

069269_0225_SL.TXT tctgcagctc tcctgatggg tgggggtcct tttgctggga ttctatactc ttattctaag atagtttcct ccatacttgg gatctcatca gctcagggca agtataaagc attttccacc tgtgcatccc acctctcagt tgtctcctta tttttttgtt ctggtcttgg agtgtacctc agctccgctg ctccccagag ctcccactcg agtgcagttg cctcagtgat gtatacagtg gtcacaccca tgctaaaccc cttcatctac agcctgagga acagagacat aaagagagct ctgaaaagat tctttggggt tccagtgatg taa

660

720

780

840

900

933 <210> 966 <211> 310 <212> PRT <213> Canis familiaris <400> 966

Met Gln Pro Asn Asn Asp Thr Trp Ile Ser Glu Phe Phe Leu Leu Gly 1 5 10 15 Leu Ser Glu Glu Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Phe 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Phe Ile Asp Ile Cys Val Thr Ser Thr Thr Ile Pro Asn 65 70 75 80 Ile Val Ile Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Ile Ile Phe Ser Gly Leu Asp Ile 100 105 110 Tyr Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125

Page 1084

Pro Leu 130 Gln Tyr Met Val Ile 135 069269_0225_SL.TXT Gly Leu Leu Met Asn Pro Gln Leu Cys 140 Leu Leu Val Ser Cys Ile Ala Asn Ile Leu His Ser Leu Leu Gln Thr 145 150 155 160 Ser Ile Met Leu Gln Leu Ser Phe Cys Arg Glu Val Glu Ile Ser His

165 170 175

Phe Phe Cys Glu Leu Asn His Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Met Val Met Tyr Ser Ala Ala Leu Leu Met Gly Gly 195 200 205 Gly Pro Phe Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Leu Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Phe Cys Ser Gly Leu

245 250 255

Gly Val Tyr Leu Ser Ser Ala Ala Pro Gln Ser Ser His Ser Ser Ala 260 265 270

Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285

Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Lys Arg Phe

290 295 300 Phe Gly Val Pro Val Met 305 310

<210> 967 <211> 849 <212> DNA <213> Canis familiaris

Page 1085

069269_0225_SL.TXT <400> 967

ctgctcctgt ccttgtacct ggtcaccttc agtggaaacc tgatcatcat cctggctgtt 60 gtaatggact cccacctcca cactcccatg tacttctttc ttaccaacct gtcctttgta 120 gatgtctgtt tcacctccac taccatcccc aagatgcttc agaacaccca gactcagagc 180 aaagtcatca tctatgcagg ctgcattgca cagatttatt ttcccatagt ctttgccatg 240 ttgaatgtct ttttcctgag tgtgatggtc tttggcagat ggccatctgc tgcccccagc 300 actacatggt catcatgaat catctgctct gtggactgct ggttctggtg ttctggatca 360 tgtgtatcct gaactccttg ttacagttta atgatattgt ggctttcttt ctgtacatac 420 ttccaaatcc cccacttttt ctgtgaacgc aatcagaaat ttgcttgttc tgaccccctt 480 cttaataact tggtgatata ttttgcaact gtcttgttag ctgctggtcc ctttattggg 540 atcctttact cttattctaa gatcgtttcc tccatatgtg gaatattgtc agctcagggc 600 aagtataaag cattttccac ctgtgcatct cacctctcag ttgtctcctt atttaattgt 660 atgatacttg tgtaccttag ctctgctgct acccacagct cacagtcaag tgcaatggcc 720 ttggtgatgt atacggtggt cacactcatg ccaaacccct tcatttatag cctgaagaac 780 agagatataa agagggttct gaaagcattc tttgtgaggg aaactccacc tggccaactg 840

ttaaaagac 849 <210> 968 <211> 153 <212> PRT <213> Canis familiaris <400> 968

Met Ile Leu Trp Leu Ser Phe Cys Thr Tyr Phe Gln Ile Pro His Phe 1 5 10 15 Phe Cys Glu Arg Asn Gln Lys Phe Ala Cys Ser Asp Pro Leu Leu Asn 20 25 30 Asn Leu Val Ile Tyr Phe Ala Thr Val Leu Leu Ala Ala Gly Pro Phe 35 40 45 Ile Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser Ile Cys Gly Page 1086

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50 55 Lys Ala Phe 75 60 Ile 65 Leu Ser Ala Gln Gly 70 Lys Tyr Ser Thr Cys Ala Ser 80 His Leu Ser Val Val Ser Leu Phe Asn Cys Met Ile Leu Val Tyr Leu 85 90 95 Ser Ser Ala Ala Thr His Ser Ser Gln Ser Ser Ala Met Ala Leu Val 100 105 110 Met Tyr Thr Val Val Thr Leu Met Pro Asn Pro Phe Ile Tyr Ser Leu 115 120 125 Lys Asn Arg Asp Ile Lys Arg Val Leu Lys Ala Phe Phe Val Arg Glu 130 135 140 Thr Pro Pro Gly Gln Leu Leu Lys Asp 145 150

<210> 969 <211> 921 <212> DNA <213> Canis familiaris <400> 969 atggaacaaa gaaatcaaag ccgcgtttca caatttatcc tcctgggact ttcagaggtg 60 ggagaactac agccactgct cttttggctg ttcttttcca tgtacctgat caccttcagt 120 gggaacctgc tcatcatcct ggccattgtc atggactccc acctccacac acccatgtac 180 ttcttcctct ccaacctgtc ctttgtagac atctgtttca cctctaccac cgtccccaag 240 atgctgctga acatccagac acagagcaaa gtgatcacct atgaaggctg cctcagccag 300 atgtattttt tcatgctgtt tggaggatta gacaactttc tcttgacagt gatggcctat 360 gaccggtttg tggccatctg tcaccccctg tactacatgg tcatcatgaa tcccaagttc 420 tgtggcatcc tgcttctggc atgctggtta ttgagtgtta tggactctct attacatgac 480 ttaatggttt tccaattgtc tttctgtaca cagttagaaa tctctcactt tttctgtgaa 540 cttaaacaga tgatccaact tgcttgctct gataccttcc tcaataacct ggcaatttat 600

Page 1087

069269_0225_SL.TXT

cttgcaagtg gacttctggg ggttcttcca ctcattggta tccttttctc ttattctaga 660 attgtagctt ccattttgaa aatttcatct tctgggggcc agtataaagc attttccaca 720 tgtgggtctc acctttcagt cgtttcctta ttctatggta caggatttgg agtgtatctt 780 agttctactg ctttgcgaaa ctccagagca agtgccatag cctcggtgat gtacacagtg 840 gtcactccca tgctgaaccc ctttatctat ggtctgagga acagagactt aaagcaggcc 900 ttaagaaaac tctttagctg a 921

<210> 970 <211> 306 <212> PRT <213> Canis familiaris <400> 970

Met Glu Gln Arg Asn Gln Ser Arg Val Ser Gln Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Glu Val Gly Glu Leu Gln Pro Leu Leu Phe Trp Leu Phe Phe 20 25 30 Ser Met Tyr Leu Ile Thr Phe Ser Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Val Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Gly 85 90 95 Cys Leu Ser Gln Met Tyr Phe Phe Met Leu Phe Gly Gly Leu Asp Asn 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125

Page 1088

Pro Leu 130 Tyr Tyr Met Val Ile 135 069269_0225_SL.TXT Met Asn Pro Lys Phe Cys 140 Gly Ile Leu Leu Leu Ala Cys Trp Leu Leu Ser Val Met Asp Ser Leu Leu His Asp 145 150 155 160 Leu Met Val Phe Gln Leu Ser Phe Cys Thr Gln Leu Glu Ile Ser His 165 170 175 Phe Phe Cys Glu Leu Lys Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Leu Ala Ile Tyr Leu Ala Ser Gly Leu Leu Gly Val 195 200 205 Leu Pro Leu Ile Gly Ile Leu Phe Ser Tyr Ser Arg Ile Val Ala Ser 210 215 220 Ile Leu Lys Ile Ser Ser Ser Gly Gly Gln Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Gly Phe 245 250 255 Gly Val Tyr Leu Ser Ser Thr Ala Leu Arg Asn Ser Arg Ala Ser Ala 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Gly Leu Arg Asn Arg Asp Leu Lys Gln Ala Leu Arg Lys Leu 290 295 300

Phe Ser 305 <210> 971 <211> 855 <212> DNA <213> Canis familiaris

Page 1089

069269_0225_SL.TXT <400> 971

atggaacaag gaaaccaaac ccaaatttct gaatttatcc tcctgggcct ctcagaagag 60 gcaaagctgc agcctctctt cttttggctg tttctgtaca tgtacctggt caccttcagt 120 gggaacctgc tcatcatcct ggccatctgc tcagactcct gcctccacac cctcatgtac 180 ttcttcctcc acaatatgtc ctttgctgac atctgtttca cttctaccac catctcctag 240 atgccgctga acatctagtc tcagagcaaa gtgatcacct actaaggctg cctcagccag 300 atgtattttt tcatgctgtt tggagtatta gacaatttcc tcttgacagt gatggcctat 360 aataggtttg tggccatctg tcaccccccc ctgcactaca tggtcatcat gaaccccgag 420 ttttgtggcg tcctgcttct ggcatgctgg ttattgagtg tcatggactc tctattacat 480 gtcttaatta ttttatgact ttctttttgc acagagttga aaacccttca ctttttctgt 540 gaacctaagc aggtgatcca acttgtttgt tctgacagct tcctcattga ccccatgata 600 tatcttgcaa gtggacttct gggggttctt ctactcattg gtaccctctt ctcttactct 660 agaatcataa cttacattat gaaaatttca ggcaactata aagcattctc cacgtgtggg 720 tctcactgct cagttgtttc cttattgtat ggtacaggct ttggggtata tcttagttct 780 gctgctttgc aaaactccag ggcaaatgcc atagccttgg tgatgtacac gtggtcacac 840 ccatgctgaa cccct 855

<210> 972 <211> 82 <212> PRT <213> Canis familiaris <400> 972

Trp Asn Lys Glu Thr Lys Pro Lys Phe Leu Asn Leu Ser Ser Trp Ala 1 5 10 15 Ser Gln Lys Arg Gln Ser Cys Ser Leu Ser Ser Phe Gly Cys Phe Cys 20 25 30 Thr Cys Thr Trp Ser Pro Ser Val Gly Thr Cys Ser Ser Ser Trp Pro 35 40 45 Ser Ala Gln Thr Pro Ala Ser Thr Pro Ser Cys Thr Ser Ser Ser Thr Page 1090

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50 55 60

Ile Cys Pro Leu Leu Thr Ser Val Ser Leu Leu Pro Pro Ser Pro Arg 65 70 75 80

Cys Arg <210> 973 <211> 546 <212> DNA <213> Canis familiaris <400> 973

cactcctttc tgttcataac catgggcaat gatcagcatg tggccatctg ccacccagag 60 caccacaaca tgctcatgag tccctatggc tgtgccattg tgtgttctga tgttgggctg 120 gtggctcaat catggggaag atggtgaccg tgacaggttt tcacctcacc ttctgtgggt 180 ctaatgtgat ccaccatttt tccagcctca tgcttggcct gtgggaagga gacatcatct 240 gtcaccttga gaggggtcct ggtgtgtgtc acagctctga tgggctgttt atgcctcatt 300 gcctccatgg tattgaggat ctcgtctgct gagggcaggc ataagaccat ctccacttgt 360 gtctcccacc tcactgtggt cattgtgcaa tatgtttttg cctccactat ctagtttcag 420 cccgtggacc catttctatg gacagtaaca ctctgatggc caccacctac agtcttcacc 480 ccctttctca gcccaatcat tttcagcctt cagtataagg agctcaaaaa tgtcataaag 540

aaatca 546 <210> 974 <211> 48 <212> PRT <213> Canis familiaris <400> 974

His Ser Phe Leu Phe Ile Thr Met Gly Asn Asp Gln His Val Ala Ile 1 5 10 15

Cys His Pro Glu His His Asn Met Leu Met Ser Pro Tyr Gly Cys Ala 20 25 30

Page 1091

069269_0225_SL.TXT

Ile Val Cys Ser Asp Val Gly Leu Val Ala Gln Ser Trp Gly Arg Trp 35 40 45 <210> 975 <211> 927 <212> DNA <213> Canis familiaris <400> 975

atcgtgtctg aattcatcct cgtgggcttc tccaccttcc cacagcatct cctgcctgcc 60 ttctttctgt tctacttgct gatgtacctg ttcatgctgt tggggaacct gctcatcatg 120 gctactatct ggagtgagca cagcctgcac acacccatgt acctcttcct gtgtgccctg 180 tccacctctg agattctgtt cactgttgcc gtcacccccc gcatgctggt tgacatgctt 240 tccagccacc gttccatcac ctttgtggcc tgtgccaccc agatgttctt ttccttcaca 300 tttggcttca cccattcctt cttgctcatg atcatgggtt atgaccgcta tgtggccatc 360 tgccaccccc tgcgatacta catgctcatg agcatccgca cctgtgcccg tttggtgtcc 420 tggacctggg ctggtggctc agtcatgggg atgatggtga ctctgatagt ttttcacctc 480 accttctgtg gatctaatgt gattcaccat tttgtctgcc atgtgttttc cctcttaaag 540 ttggcttgcg ggaatgagaa ttcgtctgtc accttgggtg tgatcctcat gtgtgtctca 600 gctctgatgg gctgtttatt cctcatcatc ctctcctaca tcttcattgt ggccgccata 660 ttgaggatcc cctctgttga gggaaggcac aagacctttt caacctgtgt gtctcacctc 720 actattgtta ttgtgcacta cagttttgcc tccattatct acctcaagcc caagggctct 780 cattctatgg acagtaacac tctgatggcc accacctata cagtctttac cccgtttctc 840 agcccaatca tttttagcct caggaataag gagctcaaaa atgccataaa gaaaagcttc 900 cagagaaaat tcagtcccct aaactcc 927

<210> 976 <211> 309 <212> PRT <213> Canis familiaris <400> 976

Ile Val Ser Glu Phe Ile Leu Val Gly Phe Ser Thr Phe Pro Gln His 1 5 10 15

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Leu Leu Pro Ala 20 Phe Phe Leu Phe Tyr Leu Leu Met Tyr Leu Phe Met 25 30 Leu Leu Gly Asn Leu Leu Ile Met Ala Thr Ile Trp Ser Glu His Ser 35 40 45 Leu His Thr Pro Met Tyr Leu Phe Leu Cys Ala Leu Ser Thr Ser Glu 50 55 60 Ile Leu Phe Thr Val Ala Val Thr Pro Arg Met Leu Val Asp Met Leu 65 70 75 80 Ser Ser His Arg Ser Ile Thr Phe Val Ala Cys Ala Thr Gln Met Phe 85 90 95 Phe Ser Phe Thr Phe Gly Phe Thr His Ser Phe Leu Leu Met Ile Met 100 105 110 Gly Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Tyr Met 115 120 125 Leu Met Ser Ile Arg Thr Cys Ala Arg Leu Val Ser Trp Thr Trp Ala 130 135 140 Gly Gly Ser Val Met Gly Met Met Val Thr Leu Ile Val Phe His Leu 145 150 155 160 Thr Phe Cys Gly Ser Asn Val Ile His His Phe Val Cys His Val Phe 165 170 175 Ser Leu Leu Lys Leu Ala Cys Gly Asn Glu Asn Ser Ser Val Thr Leu 180 185 190 Gly Val Ile Leu Met Cys Val Ser Ala Leu Met Gly Cys Leu Phe Leu 195 200 205 Ile Ile Leu Ser Tyr Ile Phe Ile Val Ala Ala Ile Leu Arg Ile Pro 210 215 220

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Ser 225 Val Glu Gly Arg His 230 Lys Thr Phe Ser Thr Cys 235 Val Ser His Leu 240 Thr Ile Val Ile Val His Tyr Ser Phe Ala Ser Ile Ile Tyr Leu Lys 245 250 255 Pro Lys Gly Ser His Ser Met Asp Ser Asn Thr Leu Met Ala Thr Thr 260 265 270 Tyr Thr Val Phe Thr Pro Phe Leu Ser Pro Ile Ile Phe Ser Leu Arg 275 280 285 Asn Lys Glu Leu Lys Asn Ala Ile Lys Lys Ser Phe Gln Arg Lys Phe 290 295 300 Ser Pro Leu Asn Ser

305 <210> 977 <211> 930 <212> DNA <213> Canis familiaris <400> 977

atggtgtctg aattcatcct cgtgggcttc tccaccttcc cacagcatct cttgcctgcc 60 tttttcctgt tctacttgct gatgtacctg ttcacgctgc tggggaacct gctcatcatg 120 gctactgtct ggagtgagcg cagcctgcac acacccatgt acctcttcct gtgtgccctg 180 tccacctctg agattctctt cactgttgcc atcacccccc gcatgctggt tgacatgctc 240 tccagccacc gctccatcac ttttatggac tgtgccaccc agatgttctt ctccttcacg 300 tttggcttca cccattcctt cttgctcatg atcatgggct atgaccgcta tgtagccatc 360 tgccaccccc tgcgctacaa catgctcatg agcacccgca cctgtgcccg tttggtgtcc 420 tggacctggg ctggtggctc agtcatgggg atgatggtga ccctgatagt ttttcatctc 480 accttctgta agtctaatgt gattcatcat tttttctgcc atgtgctttc cctcctaaag 540 ttgtcttgtg ggaatgagaa ttcctctgtc accttgagag tgattctggt gtgtgtctca 600 gctctgatgg gctgcttatt cctcatcgtc ctctcctaca tcttcattgt ggccgccata 660

Page 1094

069269_0225_SL.TXT ttgaggatcc cctctgctga gggcagacac aagacattct ctacctgtgt gtcccacctc actattgtta ttgtgcacta tggttttgcc tccattatct acctcaagcc caagggcccc cattctatgg acagtaacac cctgatggcc accacatata cagtcttcac cccgtttctc agcccaatca ttttcagcct caggaataag gagctcaaga atgccataaa gaaaagcttc cagagaaaat tcagtcccct aagttcctga

720

780

840

900

930 <210> 978 <211> 309 <212> PRT <213> Canis familiaris <400> 978

Met 1 Val Ser Glu Phe Ile Leu Val Gly Phe Ser Thr Phe Pro Gln His 5 10 15 Leu Leu Pro Ala Phe Phe Leu Phe Tyr Leu Leu Met Tyr Leu Phe Thr 20 25 30 Leu Leu Gly Asn Leu Leu Ile Met Ala Thr Val Trp Ser Glu Arg Ser 35 40 45 Leu His Thr Pro Met Tyr Leu Phe Leu Cys Ala Leu Ser Thr Ser Glu 50 55 60 Ile Leu Phe Thr Val Ala Ile Thr Pro Arg Met Leu Val Asp Met Leu 65 70 75 80 Ser Ser His Arg Ser Ile Thr Phe Met Asp Cys Ala Thr Gln Met Phe 85 90 95 Phe Ser Phe Thr Phe Gly Phe Thr His Ser Phe Leu Leu Met Ile Met 100 105 110 Gly Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Asn Met 115 120 125 Leu Met Ser Thr Arg Thr Cys Ala Arg Leu Val Ser Trp Thr Trp Ala

130 135 140

Page 1095

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Gly 145 Gly Ser Val Met Gly 150 Met Met Val Thr Leu 155 Ile Val Phe His Leu 160 Thr Phe Cys Lys Ser Asn Val Ile His His Phe Phe Cys His Val Leu 165 170 175 Ser Leu Leu Lys Leu Ser Cys Gly Asn Glu Asn Ser Ser Val Thr Leu 180 185 190 Arg Val Ile Leu Val Cys Val Ser Ala Leu Met Gly Cys Leu Phe Leu 195 200 205 Ile Val Leu Ser Tyr Ile Phe Ile Val Ala Ala Ile Leu Arg Ile Pro 210 215 220 Ser Ala Glu Gly Arg His Lys Thr Phe Ser Thr Cys Val Ser His Leu 225 230 235 240 Thr Ile Val Ile Val His Tyr Gly Phe Ala Ser Ile Ile Tyr Leu Lys 245 250 255 Pro Lys Gly Pro His Ser Met Asp Ser Asn Thr Leu Met Ala Thr Thr 260 265 270 Tyr Thr Val Phe Thr Pro Phe Leu Ser Pro Ile Ile Phe Ser Leu Arg 275 280 285 Asn Lys Glu Leu Lys Asn Ala Ile Lys Lys Ser Phe Gln Arg Lys Phe 290 295 300 Ser Pro Leu Ser Ser

305 <210> 979 <211> 1032 <212> DNA <213> Canis familiaris <400> 979

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atgacactgt ctcatccttg tccttcatgg aataaatcat gtatcttcat atcctttctg 60 gcctcagcag atgcagcttc cgtggctggt cagaactata gcatggtgtc tgaattcatc 120 ctcgtgggct tctccacctt cccacagcat ctcctgcctg tcttctttct gttctacttg 180 ctgatgtacc tgttcacgct gctggggaac ctgctcatca tggctactgt ctggagtgag 240 cgcagcctgc acacgcccat gtacctcttc ctgtgtgccc tgtccatctc tgagattctg 300 ttcactgtta ccctcacccc ccgcatgctg gttgacatgc tctccagcca ccgctccatc 360 acctttgtgg cctgtgccac ccagatgttc ttctccttca cgtttggctt cacccattcc 420 ttcttgctca tgatcatggg ctatgaccgc tacgtggcca tctgccaccc cctgcgctac 480 aacgtgctca tgagcccccg tggatgtgcc cgcctcgtgt cctggacctg ggctggtggc 540 tcagtcatgg ggatgatggt gaccctgata gtttttcatc tcaccttctg tgggtctaac 600 gtgatccacc attttgcttg ccatgtgctt tccctcctac agttggcctg tgggaaggag 660 acattctctg tcaccttggg agtgattctg gtgtgtgtct cagctctgat gggctgctta 720 tccctcatcg tcctctctta tgtcttcatc gtggctgcca tcttgaggat cccgtctgct 780 gagggcagac acaagacctt ctccacctgt gtgtcccacc tcactgtggt cattgtgcac 840 tatggttttg cctccattat ctacctcaag cccaagggcc cccattctac ggacagtaac 900 actctaatgg ccaccaccta tatagtcttc accccgtttc tcagcccaat cattttcagc 960 ctcaggaata aggagctcaa gaatgccata aagaaaagct tccagagaaa attcagtccc 1020 cttagctcct ga 1032

<210> 980 <211> 343 <212> PRT <213> Canis familiaris <400> 980

Met Thr Leu Ser His Pro Cys Pro Ser Trp Asn Lys Ser Cys Ile Phe 1 5 10 15 Ile Ser Phe Leu Ala Ser Ala Asp Ala Ala Ser Val Ala Gly Gln Asn 20 25 30 Tyr Ser Met Val Ser Glu Phe Ile Leu Val Gly Phe Ser Thr Phe Pro Page 109 7

069269_0225_SL.TXT 40 45

Gln His Leu Leu Pro Val Phe Phe Leu Phe Tyr Leu Leu Met Tyr Leu 50 55 60 Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala Thr Val Trp Ser Glu 65 70 75 80 Arg Ser Leu His Thr Pro Met Tyr Leu Phe Leu Cys Ala Leu Ser Ile 85 90 95 Ser Glu Ile Leu Phe Thr Val Thr Leu Thr Pro Arg Met Leu Val Asp 100 105 110 Met Leu Ser Ser His Arg Ser Ile Thr Phe Val Ala Cys Ala Thr Gln 115 120 125 Met Phe Phe Ser Phe Thr Phe Gly Phe Thr His Ser Phe Leu Leu Met 130 135 140 Ile Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr 145 150 155 160 Asn Val Leu Met Ser Pro Arg Gly Cys Ala Arg Leu Val Ser Trp Thr 165 170 175 Trp Ala Gly Gly Ser Val Met Gly Met Met Val Thr Leu Ile Val Phe 180 185 190 His Leu Thr Phe Cys Gly Ser Asn Val Ile His His Phe Ala Cys His 195 200 205 Val Leu Ser Leu Leu Gln Leu Ala Cys Gly Lys Glu Thr Phe Ser Val 210 215 220 Thr Leu Gly Val Ile Leu Val Cys Val Ser Ala Leu Met Gly Cys Leu 225 230 235 240 Ser Leu Ile Val Leu Ser Tyr Val Phe Ile Val Ala Ala Ile Leu Arg

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245

255

069269_0225_SL.TXT

250

Ile Pro Ser Ala Glu Gly Arg His 260 Lys Thr Phe Ser Thr Cys Val Ser 265 270 His Leu Thr Val Val Ile Val His Tyr Gly Phe Ala Ser Ile Ile Tyr 275 280 285 Leu Lys Pro Lys Gly Pro His Ser Thr Asp Ser Asn Thr Leu Met Ala 290 295 300 Thr Thr Tyr Ile Val Phe Thr Pro Phe Leu Ser Pro Ile Ile Phe Ser 305 310 315 320 Leu Arg Asn Lys Glu Leu Lys Asn Ala Ile Lys Lys Ser Phe Gln Arg 325 330 335 Lys Phe Ser Pro Leu Ser Ser 340

<210> 981 <211> 936 <212> DNA <213> Canis familiaris <400> 981 atggaagcag gaaaccatac cagagtgtca gaatttttcc tccagggcct ctcagatgat 60 ccagaactgc agcccttcct ctttggctta tttctcttca tgtacctggt caccatgctg 120 ggaaatctgc tcatcatcct ggctatcctc tctgactccc atctccacac tcccatgtac 180 ttcttcctct ccaatctatc ttctgttgat atctgtttca tctctaccac tgtcccaaag 240 atgctggtaa acatccagac acacagcaaa gacatctcct acactggatg cctcattcag 300 gtgtattttt ttatgatttt tgccgggatg gatggtttcc tcctgaccgt gatggcctat 360 gaccggtttg tggctatctg ccaccccctg cgctacacaa tcatcatgaa cccacggctg 420 tgtggcttgc tggttctgat gtgttggttt atcattttct gggtctccct gattcatgtc 480 ctactggtga ggcagctgac cttctgtcca ggcacagaaa ttccacattt cttctgtgaa 540 gtggttcaga tcctcaaggt ggcctgctct gataccctca tcaataacat cttcttgtat 600

Page 1099

069269_0225_SL.TXT gtgtccactg tcatattggg tgtgtttcct ctcagtggga tcttcttttc atactctctg attgtctcct ctttaatgaa aatgtcctct gcagcaggaa aatataaagc attttccact tgtgggtctc acctctctgt ggtctccttg tactatggga caagcctggg gctctatttc agtccttctg caactcattc ttcccagagc tccattggct cagtgatgta tactgtggtc acccccatgc tgaatccctt catctatagc ctgagaaata aggatgtgaa gggcgccctg gcaagactcc acagtcgagg aaccctttgt atgtga

660

720

780

840

900

936 <210> 982 <211> 311 <212> PRT <213> Canis familiaris <400> 982

Met Glu Ala Gly Asn His Thr Arg Val Ser Glu Phe Phe Leu Gln Gly 1 5 10 15 Leu Ser Asp Asp Pro Glu Leu Gln Pro Phe Leu Phe Gly Leu Phe Leu 20 25 30 Phe Met Tyr Leu Val Thr Met Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Leu Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Ser Val Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr His Ser Lys Asp Ile Ser Tyr Thr Gly 85 90 95 Cys Leu Ile Gln Val Tyr Phe Phe Met Ile Phe Ala Gly Met Asp Gly 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125

Page 1100

Pro Leu 130 Arg Tyr Thr Ile Ile 135 069269_0225_SL.TXT Met Asn Pro Arg Leu Cys 140 Gly Leu Leu Val Leu Met Cys Trp Phe Ile Ile Phe Trp Val Ser Leu Ile His Val 145 150 155 160 Leu Leu Val Arg Gln Leu Thr Phe Cys Pro Gly Thr Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Val Val Gln Ile Leu Lys Val Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Phe Leu Tyr Val Ser Thr Val Ile Leu Gly Val 195 200 205 Phe Pro Leu Ser Gly Ile Phe Phe Ser Tyr Ser Leu Ile Val Ser Ser 210 215 220 Leu Met Lys Met Ser Ser Ala Ala Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Thr Ser Leu 245 250 255 Gly Leu Tyr Phe Ser Pro Ser Ala Thr His Ser Ser Gln Ser Ser Ile 260 265 270 Gly Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Ala Arg Leu His 290 295 300 Ser Arg Gly Thr Leu Cys Met 305 310

<210> 983 <211> 939 <212> DNA <213> Canis familiaris

Page 1101

069269_0225_SL.TXT <400> 983 atggaagcag ggaaccaaac agctgtttta aaattcatcc ttctggggct ttcagaagat 60 gtggacttgc agcccctcct ctttgggctg ttcctctaca tgtacctagt ctgtgttata 120 gggaacctgc tcatcatcct ggccatcagc ttgcactcca acctccacac ccctatgtac 180 ttcttcctct ccaatctgtc cctcagtgac atcggtttca cctccaccac cgtcctcacg 240 atgttagtga acatccagac acggaccaac accatcacgt atgaaggctg ccttacccag 300 atgtattttt tcatgatttt tgctggacta gataatttgc tactgacagt gatggcctat 360 gatcggtttg tggccatctg tcaccccctg cactacacag tcattatgaa ccctcgcctt 420 tgtgtcctcc tgcttctgct ttcttggtta atctgcctta cgtattcttt gttgcaaagt 480 ttgatggttt tgagggtgtc cttctgcaaa gagacagaaa tcccccactt cttctgtgaa 540 cttactcaga tcctcaagct tgcctgctct gacaccctca tcaatgacat cctgctgtat 600 tttgtaagtg gcctgctggg tgttattccc ctgactggga tccttttttc ttattcgaaa 660 attatctcct gcataatggg catttcctcg gttgcaggga agtataaagc cttttccacc 720 tgtgggtctc acctcttggt tgtctccttg ttctatggtg taggccttgg ggtctacctc 780 acttctggaa caacccatcc ctccagaaag ggctcaatag cctcggtgat gtatacggtg 840 gtcaccccca tgctgaatcc cttcatctat agtctgagga acagggacat gaaaggggct 900 ctgaggagac ttttcaggag tggagcttac tctccgtga 939 <210> 984 <211> 312 <212> PRT <213> Canis familiaris <400> 984

Met 1 Glu Ala Gly Asn Gln Thr Ala Val Leu Lys Phe Ile Leu Leu Gly 5 10 15 Leu Ser Glu Asp Val Asp Leu Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Tyr Met Tyr Leu Val Cys Val Ile Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45

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Ile Ser 50 Leu His Ser Asn Leu His 55 Thr Pro Met Tyr Phe Phe Leu 60 Ser Asn Leu Ser Leu Ser Asp Ile Gly Phe Thr Ser Thr Thr Val Leu Thr 65 70 75 80 Met Leu Val Asn Ile Gln Thr Arg Thr Asn Thr Ile Thr Tyr Glu Gly 85 90 95 Cys Leu Thr Gln Met Tyr Phe Phe Met Ile Phe Ala Gly Leu Asp Asn 100 105 110 Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Val Leu Leu 130 135 140 Leu Leu Leu Ser Trp Leu Ile Cys Leu Thr Tyr Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Val Leu Arg Val Ser Phe Cys Lys Glu Thr Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Thr Gln Ile Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asp Ile Leu Leu Tyr Phe Val Ser Gly Leu Leu Gly Val 195 200 205 Ile Pro Leu Thr Gly Ile Leu Phe Ser Tyr Ser Lys Ile Ile Ser Cys 210 215 220 Ile Met Gly Ile Ser Ser Val Ala Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Leu Val Val Ser Leu Phe Tyr Gly Val Gly Leu 245 250 255

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Gly Val Tyr Leu Thr Ser Gly Thr Thr 265 His Pro Ser Arg Lys 270 Gly Ser 260 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Arg Arg Leu 290 295 300 Phe Arg Ser Gly Ala Tyr Ser Pro 305 310

<210> 985 <211> 939 <212> DNA <213> Canis familiaris <400> 985

atggaatcag aaaacagaac agaagtatca gaattcatcc tcctgggtct ctcagaggat 60 ccagaactgc tgccccttct ctttgggctg ttcctgacca tgtacctggt caccatgctg 120 gggaacctgc tcatcatcct ggcggttgga tctgactccc acctccacac ccccatgtac 180 ttcttcctcg ccaacctgtc ttttgttgac atctctttca cctccactat agtcccaaag 240 atgctggtga acatccaaac gcagaacaaa gccatcacct atgccggctg cctcactcag 300 ctatattttt tcatggtgtt tatatgcatg gacaatttac tgctaactgt gatggcttac 360 gaccgctatg tggccatctg ccatcctcta tattacgtgg tcatcatgaa ccctcgcctc 420 tgtagcctgc tgattcttgt ctctctgttt attagcatta tgagcgccct gctccatagt 480 ctgatggtgt tgcaactgtc cttctgcaca gacttgaaaa tcccccactt cttctgtgag 540 cttgctcaga tcctcaaact tgcctgttct gatactctta tcaataacat cctggtgtat 600 ttaatgacca gcttgttggg tgttggccct ctctcaggaa taattttctc ttacactcgt 660 attgtctcct ccatcctgag agtcccatca actaatggaa aggtcaaagc tttttccacc 720 tgtgggtctc acctgtctgt tgttttctta ttctatggga catgtgttgg agtgtacctt 780 agttctgcag cttccctctc ccccagaagg agagcagcgg cctcagtgat gtacacggtg 840 gtcactccca tgatgaatcc cttcatctac agcctcagga atagagacat gaagggagcc 900

Page 1104

069269_0225_SL.TXT ttgcgaaaac tcacctctgg aacgtcttcc ttttcatga 939 <210> 986 <211> 312 <212> PRT <213> Canis familiaris <400> 986

Met 1 Glu Ser Glu Asn 5 Arg Thr Glu Val Ser Glu Phe Ile Leu Leu Gly 10 15 Leu Ser Glu Asp Pro Glu Leu Leu Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Thr Met Tyr Leu Val Thr Met Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Gly Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Ser Phe Thr Ser Thr Ile Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr Gln Asn Lys Ala Ile Thr Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Leu Tyr Phe Phe Met Val Phe Ile Cys Met Asp Asn 100 105 110 Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Tyr Tyr Val Val Ile Met Asn Pro Arg Leu Cys Ser Leu Leu 130 135 140 Ile Leu Val Ser Leu Phe Ile Ser Ile Met Ser Ala Leu Leu His Ser 145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Thr Asp Leu Lys Ile Pro His 165 170 175

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Phe Phe Cys Glu Leu Ala Gln Ile Leu Lys Leu Ala Cys Ser 190 Asp Thr 180 185 Leu Ile Asn Asn Ile Leu Val Tyr Leu Met Thr Ser Leu Leu Gly Val 195 200 205 Gly Pro Leu Ser Gly Ile Ile Phe Ser Tyr Thr Arg Ile Val Ser Ser 210 215 220 Ile Leu Arg Val Pro Ser Thr Asn Gly Lys Val Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Phe Leu Phe Tyr Gly Thr Cys Val 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Ser Leu Ser Pro Arg Arg Arg Ala 260 265 270 Ala Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300 Thr Ser Gly Thr Ser Ser Phe Ser

305 310 <210> 987 <211> 939 <212> DNA <213> Canis familiaris <400> 987 atgacatcag gaaacctctc agatcctaca gaattcctcc tcctgggact gtcagaggat ccagaactgc agccccttct atttttcctg ttcctgtcta tgtacctggt gtcagtgctt gggaacctgc tcatcatcct ggccattctg tatgacttcc acctccacac tcccatgtac ttcttcctct ccaatttgtc ttttgttgac atctgtttca ccaccacaac aatcccaaag

120

180

240

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atgcttgtaa acatccggac acacagcaaa tccatcactt acacaggctg cctcacacaa 300 atctgctttg tcctgacttt tgctggatta gaaaatggaa tactggtaat gatggccttt 360 gatcgatttg tggccatctg tcacccattg aggtacaatg tcatcatgaa tcccaaactc 420 tgtaggctgc tggttctact gtccttcctt attagtgttt tggatgccct tctccacact 480 ttgatggcgt tgcggctgtc cttctgcaca gacctggaaa ttccccactt tttctgtgaa 540 ttagctcata ttctcaagct tgcctgttcc gatatcctca tcaataatat tcttgtgtat 600 ttagtgacca gcttgttggg tgttattcct ctctctggga taattatctc ttacactcaa 660 attgtttcct ctgtcctgaa aatcccatca gctggtggaa agtataaggc attttccatc 720 tgtgggtcac acttaatagt tgtttctttg ttctatggga caggttttag ggtgtacctt 780 agttccgcag ctacacactc ctccaggaag agcgcaatag tatcagtgat gtacactgtg 840 gtcaccccca tgatgaatcc ctttatctat agtctgagaa acaaggatat gatgggggct 900 ttgaggaaat tgatttctag aatatcatat ttccattaa 939

<210> 988 <211> 312 <212> PRT <213> Canis familiaris <400> 988

Met 1 Thr Ser Gly Asn 5 Leu Ser Asp Pro Thr Glu Phe Leu 10 Leu Leu 15 Gly Leu Ser Glu Asp Pro Glu Leu Gln Pro Leu Leu Phe Phe Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Ser Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Leu Tyr Asp Phe His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Thr Thr Thr Ile Pro Lys 65 70 75 80

Met

Leu Val Asn

Ile Arg Thr His

Ser Lys Ser Ile Thr Tyr Thr Gly Page 1107

069269_0225_SL.TXT

85 90 95

Cys Leu Thr Gln Ile 100 Cys Phe Val Leu Thr Phe Ala Gly Leu Glu Asn 105 110 Gly Ile Leu Val Met Met Ala Phe Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Asn Val Ile Met Asn Pro Lys Leu Cys Arg Leu Leu 130 135 140 Val Leu Leu Ser Phe Leu Ile Ser Val Leu Asp Ala Leu Leu His Thr 145 150 155 160 Leu Met Ala Leu Arg Leu Ser Phe Cys Thr Asp Leu Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Ala His Ile Leu Lys Leu Ala Cys Ser Asp Ile 180 185 190 Leu Ile Asn Asn Ile Leu Val Tyr Leu Val Thr Ser Leu Leu Gly Val 195 200 205 Ile Pro Leu Ser Gly Ile Ile Ile Ser Tyr Thr Gln Ile Val Ser Ser 210 215 220 Val Leu Lys Ile Pro Ser Ala Gly Gly Lys Tyr Lys Ala Phe Ser Ile 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Gly Phe 245 250 255 Arg Val Tyr Leu Ser Ser Ala Ala Thr His Ser Ser Arg Lys Ser Ala 260 265 270 Ile Val Ser Val Met Tyr Thr Val Val Thr Pro Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Met Gly Ala Leu Arg Lys Leu

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290 295 300

Ile Ser Arg Ile Ser Tyr Phe His

305 310 <210> 989 <211> 939 <212> DNA <213> Canis familiaris <400> 989 atggaaccta gaaatgaaac agtcattata gaatttcttc tcatggaagt gacagataat 60 ccagaactgc agtccctcat cttcatcctg ttcctattca tgtacctggt cactgtcctg 120 ggaaacctgc tcatcatcct ggctgtcatc tctgactccc atcttcatat ccccatgtac 180 ttctttcttt ttattctgtc atttactgac atctgtttaa gtacaaccac aatcccaaag 240 atactggtga atatccatac acagaaccag agcatcactt atgcaggctg cctcacacag 300 atctgctttg tcatggtttt tgcaagtttg gatagttgta ttctttcagt aatggcctat 360 gatcgctatg tggccatctg tcatccactg aggtacacag tcatcatgaa ctcccacctc 420 tgtggcctct tgattcttct ctccctgttt attagcattg tggatgcctt gatacacaat 480 ctgatggtgt tgcatctgtc cttctgcaca gaactcgaaa tccctctctt cttctgtgaa 540 gttattcagg ttatcaagat cgcatgttct gacaccctca tcaataacat cctgatatat 600 tttgcaacca gcatatttgg tggtattcct ctgtgtggaa tcattttctc ttacactcag 660 gtagtgtctt cagttttgag aatgtcatca gcaggtacaa agtataaagc tttttctacc 720 tgtgggtctc acctgtcagt tgtgtctttg ttctatggga cagcttttgg ggtgtacatt 780 agttctgctc tcactagctc ttccagaaac actgcagtgg tttcaatgat gtacactgtt 840 gtccctcaaa tgatgaaccc cttcatctac agcctgagga acagggacat gaagggagcc 900 ttgaggaaac tcataagtag aatgccttct cttctgtga 939 <210> 990 <211> 312 <212> PRT <213> Canis familiaris <400> 990

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Met 1 Glu Pro Arg Asn 5 Glu Thr Val Ile Ile Glu Phe Leu Leu Met Glu 10 15 Val Thr Asp Asn Pro Glu Leu Gln Ser Leu Ile Phe Ile Leu Phe Leu 20 25 30 Phe Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ile Ser Asp Ser His Leu His Ile Pro Met Tyr Phe Phe Leu Phe 50 55 60 Ile Leu Ser Phe Thr Asp Ile Cys Leu Ser Thr Thr Thr Ile Pro Lys 65 70 75 80 Ile Leu Val Asn Ile His Thr Gln Asn Gln Ser Ile Thr Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Ile Cys Phe Val Met Val Phe Ala Ser Leu Asp Ser 100 105 110 Cys Ile Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Ser His Leu Cys Gly Leu Leu 130 135 140 Ile Leu Leu Ser Leu Phe Ile Ser Ile Val Asp Ala Leu Ile His Asn 145 150 155 160 Leu Met Val Leu His Leu Ser Phe Cys Thr Glu Leu Glu Ile Pro Leu 165 170 175 Phe Phe Cys Glu Val Ile Gln Val Ile Lys Ile Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Thr Ser Ile Phe Gly Gly 195 200 205

Page 1110

Ile Pro 210 Leu Cys Gly Ile Ile 215 069269_0225_SL.TXT Phe Ser Tyr Thr Gln Val 220 Val Ser Ser Val Leu Arg Met Ser Ser Ala Gly Thr Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Ala Phe 245 250 255 Gly Val Tyr Ile Ser Ser Ala Leu Thr Ser Ser Ser Arg Asn Thr Ala 260 265 270 Val Val Ser Met Met Tyr Thr Val Val Pro Gln Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300 Ile Ser Arg Met Pro Ser Leu Leu

305 310

<210> 991 <211> 939 <212> DNA <213> Canis familiaris <400> 991 atggaaccca gaaatgatac acatgtttca gatttccttc tcatgagagt gacagagaat 60 ccagaactgc agttccccct attcattctg ttcgtgtcca tgtacctggt caccatcctg 120 ggaaacctgc tcatcatcct ggctgtcatc tatgactccc atctccacac ccccatgtac 180 ttctttctct ccaatctgtc tattaatgac atctgtttaa gcacaaccac catcccaaag 240 atgctggtga acatccaaac acagaatcaa agcatcactt acacaggctg cctcgcacag 300 atctgctttg tcctgatttt tgcaagttta gaaagtagtc ttcttgcagt aatggcttat 360 gaccgctatg tggccatctg tcatccactg aggtacacag tcatcatgaa ctcccacctc 420 tgtggcctct tgattctact gcctctgttt attatcattg tggatgccct gatgcacagt 480 ctgatggtgt tgcatctgtc cttctgcaca gaacttgaaa tccctctctt cttctgtgaa 540

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gttgttcagg ttatcaagat tgcatgttct gacaccctca tcaataacat cctgatatat 600 tttgcaacca gcgtatttgg tggtattccg ctgtgtggaa tcattttctc ctacactaag 660 atagtgtctt ctgttttgag aatgccatca gcaggtacga agtataaagc tttttctacc 720 tgtgggtctc acctgtcagt tgtgtctttg ttctatggga ccggtttggg ggtgtacatt 780 agttctgctc tcactagttc ttccagaaac actgcagtgg tttcaatgat gtacactgtt 840 gtccctcaaa tgatgaaccc cttcatctac agcctgagga acagggacat gaagggagcc 900 ttgaggaaac tcataagtag aatgccttct cttctgtga 939 <210> 992 <211> 312 <212> PRT <213> Canis familiaris <400> 992

Met Glu Pro Arg Asn Asp Thr His Val Ser Asp Phe Leu Leu Met Arg 1 5 10 15 Val Thr Glu Asn Pro Glu Leu Gln Phe Pro Leu Phe Ile Leu Phe Val 20 25 30 Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ile Tyr Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Ile Asn Asp Ile Cys Leu Ser Thr Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr Gln Asn Gln Ser Ile Thr Tyr Thr Gly 85 90 95 Cys Leu Ala Gln Ile Cys Phe Val Leu Ile Phe Ala Ser Leu Glu Ser 100 105 110 Ser Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125

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Pro Leu 130 Arg Tyr Thr Val Ile Met Asn Ser His 135 Leu 140 Cys Gly Leu Leu Ile Leu Leu Pro Leu Phe Ile Ile Ile Val Asp Ala Leu Met His Ser 145 150 155 160 Leu Met Val Leu His Leu Ser Phe Cys Thr Glu Leu Glu Ile Pro Leu 165 170 175 Phe Phe Cys Glu Val Val Gln Val Ile Lys Ile Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Thr Ser Val Phe Gly Gly 195 200 205 Ile Pro Leu Cys Gly Ile Ile Phe Ser Tyr Thr Lys Ile Val Ser Ser 210 215 220 Val Leu Arg Met Pro Ser Ala Gly Thr Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Gly Leu 245 250 255 Gly Val Tyr Ile Ser Ser Ala Leu Thr Ser Ser Ser Arg Asn Thr Ala 260 265 270 Val Val Ser Met Met Tyr Thr Val Val Pro Gln Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300 Ile Ser Arg Met Pro Ser Leu Leu

305 310 <210> 993 <211> 954 <212> DNA

Page 1113

069269_0225_SL.TXT <213> Canis familiaris <400> 993 atgggactca gaaacaacac aggggtttca gaattccttc taatggaagt gacagaggat 60 ccagaactga agcccctcct ctttgttctg ttcctgtcca tatacctggt caccatcctg 120 ggaaacctgc tcatcatcct ggctgtcatc tgtgactccc acctccacac ccccatgtac 180 ttcttcctgt ccaacttgtc ctttactgac atctgtttaa gcacaaccac catcccaaag 240 atgctggtga acatccaagc agaggatcag agcatcactt acacaggctg cctcacacag 300 atctacttta tcctggtttt tgctagtttg gaaagttttc ttctttcagt aatggcctat 360 gaccgctatg tggccatctg tcatccactg aggtacacgg tcatcatgaa ctcccacctt 420 tgtggcctct taattctact ctctttgtgc attaacattg tggatgccct gatgcacagt 480 ctgatggtgt tgcaactgtc cttctgcaca gaccttgaaa tccctctctt cttctgtgaa 540 gttgttcagg tcatcaagat tgcatgttct gacaccctca tcaataacat cctgatatat 600 tttgcaacta gcgtatttgg tggtatccct gtgtgtggaa tcattttctc ctatactcag 660 atagtgtctt ctgttttgag aatgccatca acaggtggaa agtataaagt tttttccacc 720 tgtgggtctc acctctctgt tgtgtccttg ttctatggaa atggtttggg ggtgtacatt 780 agttctgctc ttactagctc ttccagaaac actgcggtgg tttcagtgat gtacactatt 840 gtcccccaaa tgatgaaccc cttcatctac agcctgagga acagggacat gaaaggagcc 900 ttgaggaaac tcatgagtaa gataccattg ttttttcagg aacgtgctgt ttaa 954 <210> 994 <211> 317 <212> PRT <213> Canis familiaris <400> 994

Met Gly Leu Arg Asn Asn Thr Gly Val Ser Glu Phe Leu Leu Met Glu 1 5 10 15 Val Thr Glu Asp Pro Glu Leu Lys Pro Leu Leu Phe Val Leu Phe Leu 20 25 30 Ser Ile Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Ile Leu Ala

35 40 45

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Val Ile 50 Cys Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 55 60 Asn Leu Ser Phe Thr Asp Ile Cys Leu Ser Thr Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Ala Glu Asp Gln Ser Ile Thr Tyr Thr Gly 85 90 95 Cys Leu Thr Gln Ile Tyr Phe Ile Leu Val Phe Ala Ser Leu Glu Ser 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Ser His Leu Cys Gly Leu Leu 130 135 140 Ile Leu Leu Ser Leu Cys Ile Asn Ile Val Asp Ala Leu Met His Ser 145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Thr Asp Leu Glu Ile Pro Leu 165 170 175 Phe Phe Cys Glu Val Val Gln Val Ile Lys Ile Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Thr Ser Val Phe Gly Gly 195 200 205 Ile Pro Val Cys Gly Ile Ile Phe Ser Tyr Thr Gln Ile Val Ser Ser 210 215 220 Val Leu Arg Met Pro Ser Thr Gly Gly Lys Tyr Lys Val Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Asn Gly Leu 245 250 255

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Gly Val Tyr Ile Ser Ser Ala Leu Thr 265 Ser Ser Ser Arg Asn 270 Thr Ala 260 Val Val Ser Val Met Tyr Thr Ile Val Pro Gln Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300 Met Ser Lys Ile Pro Leu Phe Phe Gln Glu Arg Ala Val 305 310 315

<210> 995 <211> 939 <212> DNA <213> Canis familiaris <400> 995

atgggactca ggaacaacac aggggtttca gaattccttc taatggaagt gacagaggat 60 ccaaaactga agcccctcct ctttgttctg ttcctgtcca tatacctggt caccatcctg 120 ggaaacctgc tcatcatcct ggctgtcatc tgtgactccc acctccacac ccccatgtac 180 ttcttcctgt ccaacttgtc ctttactgac atctgtttaa gcacaaccac catcccaaag 240 atgctggtga acatccaagc agaggatcag agcatcactt acacaggctg cctcacacag 300 atctacttta tcctggcttt tggtggtttg gaaagttttc ttctttcagt aatggcctat 360 gaccgctatg tggccatctg tcatccactg aggtacacgg tcatcatgaa ctcccacttc 420 tgtggcctct taattctact ctctttatgc attaacattg gggatgctct gatgcacagt 480 ctgatggtgt tgcaactgtc cttctgcaca gaccttgaaa tccctctctt cttctgtgaa 540 gttgttcagg tcatcaagct cgcatgttct gacaccctca tcaataacat cctgatatat 600 tttgcaacta gcgtatttgg tggtatccct gtgtgtggaa tcattttctc ctacactcag 660 atagtgtctt ctgttttgag aataccatca acaggtggaa agtataaagc cttttccacc 720 tgtgggtctc acctctctgt tgtgtccttg ttctatggga ctggtttggg ggtgtacatt 780 agttctgctc ttactagctc ttccagaaac actgcagtgg tttcagtgat gtacactgtt 840

Page 1116

900

939

069269_0225_SL.TXT gtccctcaaa tgatgaaccc cttcatctac agcctgagga acagggacat gaaaggagcc ttgaggaaac tcataagtag aatgccttct cttctgtga <210> 996 <211> 312 <212> PRT <213> Canis familiaris <400> 996

Met Gly Leu Arg Asn Asn Thr Gly Val Ser Glu Phe Leu Leu Met Glu 1 5 10 15 Val Thr Glu Asp Pro Lys Leu Lys Pro Leu Leu Phe Val Leu Phe Leu 20 25 30 Ser Ile Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ile Cys Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Thr Asp Ile Cys Leu Ser Thr Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Ala Glu Asp Gln Ser Ile Thr Tyr Thr Gly 85 90 95 Cys Leu Thr Gln Ile Tyr Phe Ile Leu Ala Phe Gly Gly Leu Glu Ser 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Ser His Phe Cys Gly Leu Leu 130 135 140 Ile Leu Leu Ser Leu Cys Ile Asn Ile Gly Asp Ala Leu Met His Ser 145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Thr Asp Leu Glu Ile Pro Leu

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165 170 175

Phe Phe Cys Glu Val Val Gln Val Ile Lys Leu Ala Cys Ser 190 Asp Thr 180 185 Leu Ile Asn Asn Ile Leu Ile Tyr Phe Ala Thr Ser Val Phe Gly Gly 195 200 205 Ile Pro Val Cys Gly Ile Ile Phe Ser Tyr Thr Gln Ile Val Ser Ser 210 215 220 Val Leu Arg Ile Pro Ser Thr Gly Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Gly Leu 245 250 255 Gly Val Tyr Ile Ser Ser Ala Leu Thr Ser Ser Ser Arg Asn Thr Ala 260 265 270 Val Val Ser Val Met Tyr Thr Val Val Pro Gln Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300 Ile Ser Arg Met Pro Ser Leu Leu

305 310 <210> 997 <211> 939 <212> DNA <213> Canis familiaris <400> 997 atgggaccca aaaaccaaac agtattttca gaattctttc tcttgggact gacagaggat ccagaactgc agtccctact cttcagcctg ttcctgtcca tatacctggc caccatcctg ggaaacgggc tcatcatcct ggctgtcatc tgtgactccc acctccacac tcccatgtac ttcttcctct ccaacctgtc ctttactgac atctgtttaa gtacaaccac catcccaaag

120

180

240

Page 1118

069269_0225_SL.TXT atgctggtga acatccaagc acagagtcac gtctgctttg tcttgacttt tgttggttta gaccgctatg tggccatctg ccatcccctg tatggcttgc tgatggtact ctcactgctc ctgatggtgc tacagttatc cttctgtaag cttggtcaga ttgtcaagct tgcctgctct tttgcagctg gcttatttgg gggtgttcct attttctcct ctgttttgag aatgccatca tgtggctctc acttgtccgt tgtgtccttc agttctgcac ttagtgactc ttccaggaag attcctcaaa tgatgaaccc ctttatctac ttgaagaaac ttttcagtag gataccttcc <210> 998 <211> 312 <212> PRT <213> Canis familiaris agcatcagtt acacaggctg cctcacccag gaaaattttc tccttgcagc aatggcctat aggtacactg ttatcatgaa cccccaactc attagcattg tcaatgccct gctccacagt gacgtggaca tcccccactt cttctgtgag gatactctca tcaatgatat tctggcatat ctctccggaa ttattttctc ttatactcaa gcgggcagga aatataaagc tttctccacc ttctatggga cagcttttgg agtatacatt actgccatgg cttcagtgat gtacatcgtg agtctgagaa atagtgacat gcagggtgcc tttctgtga

300

360

420

480

540

600

660

720

780

840

900

939 <400> 998

Met Gly Pro Lys Asn Gln Thr Val 1 5 Leu Thr Glu Asp Pro Glu Leu Gln 20 Ser Ile Tyr Leu Ala Thr Ile Leu 35 40 Val Ile Cys Asp Ser His Leu His 50 55 Asn Leu Ser Phe Thr Asp Ile Cys 65 70

Phe Ser 10 Glu Phe Phe Leu Leu 15 Gly Ser 25 Leu Leu Phe Ser Leu 30 Phe Leu Gly Asn Gly Leu Ile 45 Ile Leu Ala Thr Pro Met Tyr 60 Phe Phe Leu Ser Leu Ser Thr 75 Thr Thr Ile Pro Lys 80

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Met Leu Val Asn Ile Gln Ala Gln Ser His Ser Ile Ser Tyr Thr Gly 85 90 95 Cys Leu Thr Gln Val Cys Phe Val Leu Thr Phe Val Gly Leu Glu Asn 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Pro Gln Leu Tyr Gly Leu Leu 130 135 140 Met Val Leu Ser Leu Leu Ile Ser Ile Val Asn Ala Leu Leu His Ser 145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Lys Asp Val Asp Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Gly Gln Ile Val Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asp Ile Leu Ala Tyr Phe Ala Ala Gly Leu Phe Gly Gly 195 200 205 Val Pro Leu Ser Gly Ile Ile Phe Ser Tyr Thr Gln Ile Phe Ser Ser 210 215 220 Val Leu Arg Met Pro Ser Ala Gly Arg Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Phe Phe Tyr Gly Thr Ala Phe 245 250 255 Gly Val Tyr Ile Ser Ser Ala Leu Ser Asp Ser Ser Arg Lys Thr Ala 260 265 270 Met Ala Ser Val Met Tyr Ile Val Ile Pro Gln Met Met Asn Pro Phe 275 280 285

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Ile Tyr Ser Leu Arg Asn Ser Asp Met Gln Gly Ala Leu Lys Lys Leu 290 295 300

Phe Ser Arg Ile Pro Ser Phe Leu 305 310 <210> 999 <211> 957 <212> DNA <213> Canis familiaris <400> 999

atggaaccag aaaaccaaac aggtgtagca gaattcttcc ttctgggtct ctcagaagat 60 ccagaatggc agccccttct ctttggactg ttcctgacca tatacctggt cactgtgcta 120 ggaaacctgc tcatcatcct ggctatcagc tctgactccc accttcaaac acccatgtac 180 ttcttcctct cccacctggc gttcactgac atctgtttca gcaccaccac catccccaag 240 atgctggtga acatccaaag acagagcaaa tccatcagtt acacaggctg cctcacccag 300 gtctgctttg tcctgttttt tgcaggctta gaaaactttc tccttgcagc aatggcctat 360 gaccgctatg tggccatctg ccatccactg aggtacacag tcatcatgaa cccccacctc 420 tgtggcctgc tgattctact caccctgatc atcagcattg cagatgccct actccacagt 480 ctgatggtgt tgcgactctc cttctgcaca gatctggaaa ttccccattt tttctgtgaa 540 cttgctcagg tcatcaagct cgcctgttct gataccctca tcaataatat cctgatgtat 600 ttagtgacca gtgtattggg tggtgttcct ctccttggga ttattttctc ttacattcaa 660 attgtctctt ctactctgag aatgtcatca gctgggggga aatataaagc cttttccacc 720 tgtggggctc atctctcagt tgtttctttg ttctatggga cagcttttgg ggtgtacatt 780 agttctgcag tttctcattc ttccaaggat actgcaagag cctcagtgat gtacaccgtg 840 gtccctccaa tgttgaaccc cttcatctac agcctgagga acaaggacat gaagggagcc 900 ttgaagaaac tcatcttgtt tgctactgtg tcatctgcct tggtcttggg cttctag 957

<210> 1000 <211> 318 <212> PRT <213> Canis familiaris

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<400> 1000 Asn Gln Thr Gly Val Ala Glu Phe Phe Leu Leu 15 Gly Met 1 Glu Pro Glu 5 10 Leu Ser Glu Asp Pro Glu Trp Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Thr Ile Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ser Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ala Phe Thr Asp Ile Cys Phe Ser Thr Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Arg Gln Ser Lys Ser Ile Ser Tyr Thr Gly 85 90 95 Cys Leu Thr Gln Val Cys Phe Val Leu Phe Phe Ala Gly Leu Glu Asn 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Pro His Leu Cys Gly Leu Leu 130 135 140 Ile Leu Leu Thr Leu Ile Ile Ser Ile Ala Asp Ala Leu Leu His Ser 145 150 155 160 Leu Met Val Leu Arg Leu Ser Phe Cys Thr Asp Leu Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Ala Gln Val Ile Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Leu Met Tyr Leu Val Thr Ser Val Leu Gly Gly 195 200 205

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Val Pro Leu Leu Gly Ile Ile Phe Ser Tyr Ile Gln Ile Val Ser Ser 210 215 220 Thr Leu Arg Met Ser Ser Ala Gly Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ala His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Ala Phe 245 250 255 Gly Val Tyr Ile Ser Ser Ala Val Ser His Ser Ser Lys Asp Thr Ala 260 265 270 Arg Ala Ser Val Met Tyr Thr Val Val Pro Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Lys Lys Leu 290 295 300 Ile Leu Phe Ala Thr Val Ser Ser Ala Leu Val Leu Gly Phe 305 310 315

<210> 1001 <211> 939 <212> DNA <213> Canis familiaris <400> 1001 atggaaccca gaaatcacac agatgtttca gaatttcttc ttctgggatt gacagatgat 60 ccagaactgc agcgtttcct attctgcctg tttctgtcca tgtacctggt cactatcctg 120 ggaaatctgc tcatcatctt ggtcatcaat tctgactctc acctccacac ccccatgtac 180 ttcttcctct ccaatctgtc ttttactgac atctgtttaa gcacaaccac catcccaaag 240 atgctggtga acatccaagc acaggatcag agcatcactt acacaggctg ccttacccag 300 gttggatttg tcctggcttt tggtggtttt gaaatttttc tccttgcagc aatggcttat 360 gaccgctatg tggccatttg tcaccccttg agatacactg ttatcatgaa cccccaactc 420 tgtgttctgc tgattctgct ctcactgttc tttagctttg tggttgccct gctccacagt 480 ctaatggtgc tacgactctc cttctgcaag gacttggaaa ttcctcattt cttctgtgaa 540

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cttgctcagg tcatcaagct cgcctgttct gacaccctcg tcaataacat actgatttat 600 tttgtggcta gcctatttgg tggtattcct ctctctggga tcattttctc ttatactcaa 660 atcgtttcct ctgttttgag aatgccatca gcagggggaa agctcaaagc tttttccacc 720 tgtgggtctc acctgtcagt tgtgtccttg ttctatggga cagttgttgg agtgtacatt 780 agttctgtag ttagtgactc ttccaagaag actgcagtgg cttcagtgat gtatgttgtg 840 gttcctcaaa tgatgaaccc ctttatctat agcctacgga atagggacat gaaaggagcc 900 ttgagaaagc tcatcagtgg gatgccttct ttgctgtga 939

<210> 1002 <211> 312 <212> PRT <213> Canis familiaris

<400> 1002 His Thr Asp Val Ser Glu Phe Leu Leu Leu Gly Met 1 Glu Pro Arg Asn 5 10 15 Leu Thr Asp Asp Pro Glu Leu Gln Arg Phe Leu Phe Cys Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Ile Leu Val 35 40 45 Ile Asn Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Thr Asp Ile Cys Leu Ser Thr Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Ala Gln Asp Gln Ser Ile Thr Tyr Thr Gly 85 90 95 Cys Leu Thr Gln Val Gly Phe Val Leu Ala Phe Gly Gly Phe Glu Ile 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125

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Pro Leu 130 Arg Tyr Thr Val Ile Met Asn Pro Gln Leu Cys Val Leu Leu 135 140 Ile Leu Leu Ser Leu Phe Phe Ser Phe Val Val Ala Leu Leu His Ser 145 150 155 160 Leu Met Val Leu Arg Leu Ser Phe Cys Lys Asp Leu Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Ala Gln Val Ile Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Val Asn Asn Ile Leu Ile Tyr Phe Val Ala Ser Leu Phe Gly Gly 195 200 205 Ile Pro Leu Ser Gly Ile Ile Phe Ser Tyr Thr Gln Ile Val Ser Ser 210 215 220 Val Leu Arg Met Pro Ser Ala Gly Gly Lys Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Val Val 245 250 255 Gly Val Tyr Ile Ser Ser Val Val Ser Asp Ser Ser Lys Lys Thr Ala 260 265 270 Val Ala Ser Val Met Tyr Val Val Val Pro Gln Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300 Ile Ser Gly Met Pro Ser Leu Leu

305 310 <210> 1003 <211> 942

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069269 0225 SL.TXT <212> DNA <213> Canis familiaris <400> 1003 atggaatcaa ggaatcaatc cagcgcatcc ccagagcagg agactcttct ttttgctttg ggaaaccttt caatcatcct ggccatcagc ttcttcctgg ccaatctctc cttggttgat atgctggtga acatccaaat gaaaagcaag atgtactttt tccatttctt tggcattgtt gaccggtttg tggctatatg tcacccctta tgtggcctgc tggccggtag cccatgggtg ctcttgatgg tgcgcttggt tttctgtggg ctcactcctc ttctcaggct ttcttgcact attgtggctg ggatggtgat agccacacca atcattgtgg ccatcatgaa ggtcccttct tgcagctccc atctgtctgt ggttgctctc tgtccttcct ctgtgcgcac agctgtgaag gtcaccccca tgctgaaccc ctttatctat ctgaggaagc tttttagtaa aaagataatt <210> 1004 <211> 313 <212> PRT <213> Canis familiaris gaatttatcc tcctaggact ttcagaaaat ttcccctgca tgtatgtggt catggctatg tcagactccc accttcatac tcccatgtac tttggtctgg ctaccaacac agtccccaag tcaatctcct atccctgctg cctgacccag gatagtgtct taattgctgt gatggcttat cactacacca ccatcatgag cccacacctc ttttcctatt ttatttccct cactcatatc aacaacaaga ttcctcacta cttctgtgac gatacatctg tgaacaagat ctttgtgctc ttcatctgca tcctggcctc ctatgctcgc gcagggggca ggaagaaagc cttttccacc ctttatggga ccaccattgg ggtctatttg gagaaagcct ctgctgtgat gtacactgcg agcctgagga acagagatct taagggggcc tcatcttcct ga

120

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942

<400> 1004 Ser Met 1 Glu Ser Arg Asn Gln 5 Leu Ser Glu Asn 20 Pro Glu Gln Cys Met Tyr Val Val Met Ala

Ser Ala Ser 10 Glu Phe Ile Leu Leu 15 Gly Glu Thr Leu Leu Phe Ala Leu Phe Pro 25 30 Met Gly Asn Leu Ser Ile Ile Leu Ala Page 1126

069269_0225_SL.TXT 40 45

Ile Ser 50 Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 55 60 Asn Leu Ser Leu Val Asp Phe Gly Leu Ala Thr Asn Thr Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Met Lys Ser Lys Ser Ile Ser Tyr Pro Cys 85 90 95 Cys Leu Thr Gln Met Tyr Phe Phe His Phe Phe Gly Ile Val Asp Ser 100 105 110 Val Leu Ile Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Thr Ile Met Ser Pro His Leu Cys Gly Leu Leu 130 135 140 Ala Gly Ser Pro Trp Val Phe Ser Tyr Phe Ile Ser Leu Thr His Ile 145 150 155 160 Leu Leu Met Val Arg Leu Val Phe Cys Gly Asn Asn Lys Ile Pro His 165 170 175 Tyr Phe Cys Asp Leu Thr Pro Leu Leu Arg Leu Ser Cys Thr Asp Thr 180 185 190 Ser Val Asn Lys Ile Phe Val Leu Ile Val Ala Gly Met Val Ile Ala 195 200 205 Thr Pro Phe Ile Cys Ile Leu Ala Ser Tyr Ala Arg Ile Ile Val Ala 210 215 220 Ile Met Lys Val Pro Ser Ala Gly Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ser Val Val Ala Leu Leu Tyr Gly Thr Thr Ile

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Gly Val Tyr 245 250 Arg Thr Ala Val 255 Leu 260 Cys Pro Ser Ser Val 265 Lys 270 Glu Lys Ala Ser Ala 275 Val Met Tyr Thr Ala 280 Val Thr Pro Met Leu 285 Asn Pro Phe Ile Tyr 290 Ser Leu Arg Asn Arg 295 Asp Leu Lys Gly Ala 300 Leu Arg Lys Leu Phe 305 Ser Lys Lys Ile Ile 310 Ser Ser Ser

<210> 1005 <211> 942 <212> DNA <213> Canis familiaris <400> 1005

atggaaccaa ggaaccaaac tagtgcatcc gaattcatcc tcctggggct ttcagaaaat 60 ccagagcagg agaccctcct ctttgctctg tttctctgca tgtatgtggt cacagtagtg 120 gggaatctgc tcatcatcct ggccatcagc tcagactcct acctccacac tcccatgtac 180 ttcttcctgg ccaatctctc cttggttgat ttctgtctgg ccaccgatac agtccccaag 240 atgctagtga acatccaaat caggagcaag tcaatctcct acgcctgttg cctgacccag 300 atgtactttt tccatttctt tggcattatg gacagtgtct taattgctgt gatggcttat 360 gaccggtttg tggctatatg tcatccctta cactatacta ccatcatgag cccacgcctc 420 tgtggcctgc tggctggtgg tccatgggta ttttcctgct tcatttccct cactcatatc 480 ctcttgatgg cccgtctggt tttctgtggg agcaatgagt tgccccacta cttctgtgac 540 ctcactcctc ttctcaggct ttcttgcact gatacatctg tgaacaagat ctttgtgctc 600 attgtggctg ggatggtgat agccacacca ttcatctgca tcctggcctc ctatgctcgc 660 atcattgtgg ccatcatgaa ggtcccttct gcaggcggca ggaagaaagc cttttccacc 720 tgcagctccc atctgtctgt ggttgctctc ttctatggga ccaccattgg ggtctatttg 780 tgtccttcct ctgtgcgcac agctgtgaag gagaaagcct ctgctgtgat gtacactgcg 840

Page 1128

069269_0225_SL.TXT gtcaccccca tgctgaaccc ctttatctat agcctgagga acagagatct taagggggcc ctgaggaagc ttgtcaacag aaaaatcact tcatcttcct ga

900

942 <210> 1006 <211> 313 <212> PRT <213> Canis familiaris

<400> 1006 Gln Thr Ser Ala Ser Glu Phe Ile Leu Leu Gly Met Glu 1 Pro Arg Asn 5 10 15 Leu Ser Glu Asn Pro Glu Gln Glu Thr Leu Leu Phe Ala Leu Phe Leu 20 25 30 Cys Met Tyr Val Val Thr Val Val Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ser Asp Ser Tyr Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Leu Val Asp Phe Cys Leu Ala Thr Asp Thr Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Ile Arg Ser Lys Ser Ile Ser Tyr Ala Cys 85 90 95 Cys Leu Thr Gln Met Tyr Phe Phe His Phe Phe Gly Ile Met Asp Ser 100 105 110 Val Leu Ile Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Thr Ile Met Ser Pro Arg Leu Cys Gly Leu Leu 130 135 140 Ala Gly Gly Pro Trp Val Phe Ser Cys Phe Ile Ser Leu Thr His Ile 145 150 155 160

Page 1129

Leu Leu Met Ala Arg 165 Leu Val 069269_0225_SL.TXT Phe Cys Gly Ser Asn Glu 170 Leu Pro 175 His Tyr Phe Cys Asp Leu Thr Pro Leu Leu Arg Leu Ser Cys Thr Asp Thr 180 185 190 Ser Val Asn Lys Ile Phe Val Leu Ile Val Ala Gly Met Val Ile Ala 195 200 205 Thr Pro Phe Ile Cys Ile Leu Ala Ser Tyr Ala Arg Ile Ile Val Ala 210 215 220 Ile Met Lys Val Pro Ser Ala Gly Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ser Val Val Ala Leu Phe Tyr Gly Thr Thr Ile 245 250 255 Gly Val Tyr Leu Cys Pro Ser Ser Val Arg Thr Ala Val Lys Glu Lys 260 265 270 Ala Ser Ala Val Met Tyr Thr Ala Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Leu Lys Gly Ala Leu Arg Lys Leu 290 295 300 Val Asn Arg Lys Ile Thr Ser Ser Ser 305 310

<210> 1007 <211> 855 <212> DNA <213> Canis familiaris <400> 1007 cttctagatg attcagaact gcagtccctc caccttgggc tgttcctatc catgtacctg gtcaccatgc tcgggaacct gctaatcatc ctggctgtca gctctgactg ccatctgtac acccccatat acttctacaa tctgtccttg attgacatct gtttcatatc caccactgtc

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ccgaagatga tgtcggacat ccaaactcac agaatcatct cctgtgtggg ctcagatgtc 240 tatttttatt ctctttggat gtttggacaa tctagagact gcaaaggcct atgaccagtt 300 tgtagccacc tgtcacccct tgcactacct ggtgatcatg aatctccacc tctgtgtcgg 360 gctggttttg gtgtcttttt tttccatcag tattttggac tcctagctgc acagtttgat 420 gtcacagctt accttcttca tagatgcaga aatacctcat ctctttcatg gcccttctca 480 gcaactcgac cttgcctcct tggaaatccc tgccagtttt attttattgg tgccattttt 540 ggtggtgttc tactctcaag aatccttttc tcttacgttc aaattatttc ctccatcctg 600 agagtcacat ccataggtgg gaagtacgaa cctcttccta cttgtggctc ttgcctgtca 660 gttgtttgct tgtttttgcc tgtcagttgt ttgcttgttt ttggaacagg tcttggagtg 720 tacctcaggt tggctatccc atattctgcc aagaaaggtg aggtgatctc ggcagtgtat 780 accgtggtca cccacatgct taatcccttc ctttatagtc tgaggaacaa agcaaccaag 840 agagccatgc agagg 855 <210> 1008 <211> 97 <212> PRT <213> Canis familiaris <400> 1008 Leu Leu Asp Asp Ser Glu Leu Gln Ser Leu His Leu Gly Leu Phe Leu 1 5 10 15 Ser Met Tyr Leu Val Thr Met Leu Gly Asn Leu Leu Ile Ile Leu Ala 20 25 30 Val Ser Ser Asp Cys His Leu Tyr Thr Pro Ile Tyr Phe Tyr Asn Leu 35 40 45 Ser Leu Ile Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys Met Met 50 55 60 Ser Asp Ile Gln Thr His Arg Ile Ile Ser Cys Val Gly Ser Asp Val 65 70 75 80 Tyr Phe Tyr Ser Leu Trp Met Phe Gly Gln Ser Arg Asp Cys Lys Gly

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85 90 95

Leu <210> 1009 <211> 993 <212> DNA <213> Canis familiaris <400> 1009

atgctcattt acttgtttca cttttccaac cctcttttct tttttaaaag gtgtccaagc 60 tacatagaac cacaaaatct aacaagtgta tcagagttct tcctcatggg cctctcagat 120 gatccagaac tgcagcccct cctctttggg ctgttcctgt ccatgtacct ggtcactgtg 180 cttgggaatc tgctcatcat cttggccgtc agctctgact cccacctcca catccccatg 240 tacttcctcc tctccaacct gtccttggct gacattggtt tcacctccac cacagtcccc 300 aagatgatca tggacatcca aactcagagc agagtcatct cctatgtggg ttgcctgact 360 caaatgtctt tttttatgct ttttggatgt ttggatagtc tcctcctggc tgtgatggcg 420 tatgaccggt ttgtggccat ctgtcacccc ctgcactact tgatcatcat gaacccccgc 480 ctctgtggct tgttggtttt ggcgtcattt ttaatcagcc tgttggtctc ccagatgcac 540 aattcaattg tgttacaact tacttacttc aaggatgtgg aaatttctca tttcttctgt 600 gatccttctc aactcctcaa ccttgcctgt tctgacactt ttatcaataa catagtcatg 660 tattttgttg gtgccatctc tggctttctt cctatttcag ggatcttttt ctcttactat 720 aaaattgttt cctccattct gagagtccca tccacaggtg ggagatacaa agccttctcc 780 acctgtggct cccacctgtc agttgtttgc ttattttatg gaacaggcct tggggtgtac 840 cttagttcag ctgtctcact ttctcccagg aaggatgcag tggcctcagt ggtgtatact 900 gtggtcaccc ccatgctgaa ccctttcatc tacagcctga ggaacaggga catcaaaagg 960 gccatgtgga ggctcttcag taaaacaatc taa 993

<210> 1010 <211> 330 <212> PRT <213> Canis familiaris

Page 1132

069269_0225_SL.TXT <400> 1010

Met 1 Leu Ile Tyr Leu Phe His Phe Ser Asn Pro Leu Phe Phe Phe Lys 5 10 15 Arg Cys Pro Ser Tyr Ile Glu Pro Gln Asn Leu Thr Ser Val Ser Glu 20 25 30 Phe Phe Leu Met Gly Leu Ser Asp Asp Pro Glu Leu Gln Pro Leu Leu 35 40 45 Phe Gly Leu Phe Leu Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu 50 55 60 Leu Ile Ile Leu Ala Val Ser Ser Asp Ser His Leu His Ile Pro Met 65 70 75 80 Tyr Phe Leu Leu Ser Asn Leu Ser Leu Ala Asp Ile Gly Phe Thr Ser 85 90 95 Thr Thr Val Pro Lys Met Ile Met Asp Ile Gln Thr Gln Ser Arg Val 100 105 110 Ile Ser Tyr Val Gly Cys Leu Thr Gln Met Ser Phe Phe Met Leu Phe 115 120 125 Gly Cys Leu Asp Ser Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Phe 130 135 140 Val Ala Ile Cys His Pro Leu His Tyr Leu Ile Ile Met Asn Pro Arg 145 150 155 160 Leu Cys Gly Leu Leu Val Leu Ala Ser Phe Leu Ile Ser Leu Leu Val 165 170 175 Ser Gln Met His Asn Ser Ile Val Leu Gln Leu Thr Tyr Phe Lys Asp 180 185 190 Val Glu Ile Ser His Phe Phe Cys Asp Pro Ser Gln Leu Leu Asn Leu 195 200 205

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Ala Cys Ser Asp Thr Phe Ile Asn Asn Ile Val Met Tyr Phe Val Gly 210 215 220 Ala Ile Ser Gly Phe Leu Pro Ile Ser Gly Ile Phe Phe Ser Tyr Tyr 225 230 235 240 Lys Ile Val Ser Ser Ile Leu Arg Val Pro Ser Thr Gly Gly Arg Tyr 245 250 255 Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ser Val Val Cys Leu Phe 260 265 270 Tyr Gly Thr Gly Leu Gly Val Tyr Leu Ser Ser Ala Val Ser Leu Ser 275 280 285 Pro Arg Lys Asp Ala Val Ala Ser Val Val Tyr Thr Val Val Thr Pro 290 295 300 Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg 305 310 315 320 Ala Met Trp Arg Leu Phe Ser Lys Thr Ile

325 330 <210> 1011 <211> 990 <212> DNA <213> Canis familiaris <400> 1011

atgctcattt acttgtttca cttttccaac ccttttttct tttttgaaag gtgtctaggc 60 tacaaagaac aaaacctaac aagtgtctca gaattcttcc tcaccagatt ctcagatgat 120 ctagagctgc agcctctctt ctttgggctg ttcctgtcca tgtacctgct caccgtgctt 180 gggaatctgc tcatcatcct gactgtcagc tctgactctc acctccacac ccccatgtac 240 ttcttcctct ccaacctgtc cttggctgac atcggtttca cctccaccac agtccccaag 300 atgatcatgg acatccaaac tcagagcaga gtcatctcct atgtgggttg cctgactcaa 360

Page 1134

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atgtcttttt tgatcctttt tggatgtatg gatggtatgc ttctgactgt aatggcatat 420 gacaggtttg tggccatctg tcaccctcta cactactcaa tcatcatgaa cccccgcctc 480 tgtggcttgt tggttttggt gtcttttttg gttagccttt tggactccca gctgcacagt 540 ttgattgtgt tacaacttac ctgcttcaag gatgtggaaa tttctaattt tttctgcgat 600 ccttctcaac tcctcaacct tgcctgttct gacactttca ccaataacat agtcatgtat 660 tttgttggtg ccatctctgg ctttcttcct atttcaggga tctttttctc ttactataaa 720 attgtttcct ccattctgag agtcccatcc acaggtggga gatacaaagc cttctctacc 780 tgtggctccc acctgtcagt tgtttgctta ttttatggaa ctgctattgg agtgtacctt 840 ggatcagcat tgctgccttc ccccaggaag gatatagtgg cctcggtgat gtacactgtg 900 gtcactccca tgctgaatcc cttcatttac agcctgagaa acagggacat taagagtgcc 960 ctatggaggt tcctcagaag aacagcctaa 990

<210> 1012 <211> 329 <212> PRT <213> Canis familiaris <400> 1012

Met 1 Leu Ile Tyr Leu Phe 5 His Phe Ser Asn Pro Phe Phe Phe Phe Glu 10 15 Arg Cys Leu Gly Tyr Lys Glu Gln Asn Leu Thr Ser Val Ser Glu Phe 20 25 30 Phe Leu Thr Arg Phe Ser Asp Asp Leu Glu Leu Gln Pro Leu Phe Phe 35 40 45 Gly Leu Phe Leu Ser Met Tyr Leu Leu Thr Val Leu Gly Asn Leu Leu 50 55 60 Ile Ile Leu Thr Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr 65 70 75 80 Phe Phe Leu Ser Asn Leu Ser Leu Ala Asp Ile Gly Phe Thr Ser Thr 85 90 95

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Thr Val Pro Lys 100 Met Ile Met Asp Ile Gln Thr Gln Ser Arg Val Ile 105 110 Ser Tyr Val Gly Cys Leu Thr Gln Met Ser Phe Leu Ile Leu Phe Gly 115 120 125 Cys Met Asp Gly Met Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val 130 135 140 Ala Ile Cys His Pro Leu His Tyr Ser Ile Ile Met Asn Pro Arg Leu 145 150 155 160 Cys Gly Leu Leu Val Leu Val Ser Phe Leu Val Ser Leu Leu Asp Ser 165 170 175 Gln Leu His Ser Leu Ile Val Leu Gln Leu Thr Cys Phe Lys Asp Val 180 185 190 Glu Ile Ser Asn Phe Phe Cys Asp Pro Ser Gln Leu Leu Asn Leu Ala 195 200 205 Cys Ser Asp Thr Phe Thr Asn Asn Ile Val Met Tyr Phe Val Gly Ala 210 215 220 Ile Ser Gly Phe Leu Pro Ile Ser Gly Ile Phe Phe Ser Tyr Tyr Lys 225 230 235 240 Ile Val Ser Ser Ile Leu Arg Val Pro Ser Thr Gly Gly Arg Tyr Lys 245 250 255 Ala Phe Ser Thr Cys Gly Ser His Leu Ser Val Val Cys Leu Phe Tyr 260 265 270 Gly Thr Ala Ile Gly Val Tyr Leu Gly Ser Ala Leu Leu Pro Ser Pro 275 280 285 Arg Lys Asp Ile Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met 290 295 300

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Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Ser Ala 305 310 315 320

Leu Trp Arg Phe Leu Arg Arg Thr Ala 325 <210> 1013 <211> 1038 <212> DNA <213> Canis familiaris <400> 1013

atgaattgct tgaattcaaa atatagacac actgacagat cccagtatac ttgtttcctt 60 tatttaaact ctcatttatt tctcaaaagc tgtctctgct acacagaacc ccagaatcta 120 acagatgtct tggaattctt cctcctgggg ttctcagaag atccagaact gcagcctgta 180 atctttagcc tgttcctgtc catgtatctg gtcaccatgc tggggaatct actgatcctc 240 cttgctgtca gctctgactc ctgccttcac acccccatgt acttcttcct ttccatcctg 300 tccctggctg acatcggttt catttctacc acagtcccaa aggtgatttt ggacattgaa 360 actcacaaca gagtcatctc ccatgtgggc tgcctgattc agttgtcttt ttttaatctt 420 tttggatgtt tggacagtgt actcttaact gtgatggcct atgatcggtt tgtagccatt 480 tgttatcctc tgcactaccc agtcatcatg aacccccgcc tctgtagcct gctgattctg 540 atatcttttt taatcagcct tctggactct cagctgcact gcctcatgat gtcacaactt 600 accttctgca taaatgtgga aattcctcat ttcttctgtg accctcctca gctcctcaag 660 ctttcctgta atgatacttc caccactaaa atattcatgt gttttcttgg tgccatcttt 720 ggtggtattc cagtctcagg gatccttttc tcttacacac gaattgtttc ctccattctg 780 agagtcccat ccacaggtgg gaagtacaaa gccttctcca cctgtggctc ccacctgtca 840 gttgttatct tattttatgg aacaggtctt ggggtgtacc tcagttctac tatctcacat 900 tctcccagaa aggatgcagt ggcctcagta atgtatgctt tcattgttcc catgctaaat 960 cccttcatct acagtctgag gaacaaggac atcaagagtg ctttgcagag gctcctcaac 1020 agaaaagccc agtcttaa 1038

Page 1137

069269_0225_SL.TXT <210> 1014 <211> 345 <212> PRT <213> Canis familiaris

<400> 1014 Gln 15 Tyr Met 1 Asn Cys Leu Asn Ser Lys Tyr 5 Arg His 10 Thr Asp Arg Ser Thr Cys Phe Leu Tyr Leu Asn Ser His Leu Phe Leu Lys Ser Cys Leu 20 25 30 Cys Tyr Thr Glu Pro Gln Asn Leu Thr Asp Val Leu Glu Phe Phe Leu 35 40 45 Leu Gly Phe Ser Glu Asp Pro Glu Leu Gln Pro Val Ile Phe Ser Leu 50 55 60 Phe Leu Ser Met Tyr Leu Val Thr Met Leu Gly Asn Leu Leu Ile Leu 65 70 75 80 Leu Ala Val Ser Ser Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe 85 90 95 Leu Ser Ile Leu Ser Leu Ala Asp Ile Gly Phe Ile Ser Thr Thr Val 100 105 110 Pro Lys Val Ile Leu Asp Ile Glu Thr His Asn Arg Val Ile Ser His 115 120 125 Val Gly Cys Leu Ile Gln Leu Ser Phe Phe Asn Leu Phe Gly Cys Leu 130 135 140 Asp Ser Val Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile 145 150 155 160 Cys Tyr Pro Leu His Tyr Pro Val Ile Met Asn Pro Arg Leu Cys Ser 165 170 175 Leu Leu Ile Leu Ile Ser Phe Leu Ile Ser Leu Leu Asp Ser Gln Leu 180 185 190

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His Cys Leu Met Met Ser Gln Leu Thr Phe Cys Ile Asn Val Glu Ile 195 200 205 Pro His Phe Phe Cys Asp Pro Pro Gln Leu Leu Lys Leu Ser Cys Asn 210 215 220 Asp Thr Ser Thr Thr Lys Ile Phe Met Cys Phe Leu Gly Ala Ile Phe 225 230 235 240 Gly Gly Ile Pro Val Ser Gly Ile Leu Phe Ser Tyr Thr Arg Ile Val 245 250 255 Ser Ser Ile Leu Arg Val Pro Ser Thr Gly Gly Lys Tyr Lys Ala Phe 260 265 270 Ser Thr Cys Gly Ser His Leu Ser Val Val Ile Leu Phe Tyr Gly Thr 275 280 285 Gly Leu Gly Val Tyr Leu Ser Ser Thr Ile Ser His Ser Pro Arg Lys 290 295 300 Asp Ala Val Ala Ser Val Met Tyr Ala Phe Ile Val Pro Met Leu Asn 305 310 315 320 Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Ser Ala Leu Gln 325 330 335 Arg Leu Leu Asn Arg Lys Ala Gln Ser 340 345

<210> 1015 <211> 930 <212> DNA <213> Canis familiaris <400> 1015 atggaaccac agaatctaac aagtgtttca gaattcctcc tcctgggcct ctcagatgat ccagaactgc agcccctcct ctttgggctg ctcctgacca tgtacctggt cactgtgctt

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069269_0225_SL.TXT gggaacctgc tcatcatctt ggccgtcagc tctgactccc acctccacac ccccatgtac ttcttcctct ccaacctgtc cttggctgac attggtttca gcaccactac agtcccaaag atgctggtga acattcaaac acacagcaaa tatatcactt atgcaggctg cctaactcag atgtcctttt attttctatt tgggtgtttg gacaatctac tcctggctgt gatggcctat gaccggtttg tggccatttg tcaccccctg aactacccaa ttatcatgaa cccacgcctc tgtggcttgt tggtcctgtt gtcatttttc agcagccttt tggaatctca gattcactgt ttgatggtgt cacaacttac cttctgcaca gatgtggaaa ttcatcattt cttttgtgat gcacctcaac ttctccacct tgcctgctct tatacctcca tcaacaccat actaatctat tttattggtg ccatttttgg tggcattcca ctttcaggga tcctttgttc ttatagtaga attgcttcct ccattctgag agtcccaacc acaggtggga agtacaaagc gttctccacc tgtggctccc acctgtcagt tgtttgctta ttttatggaa caggccttgg agtgtacctc ggttcatcca tctccccctc ccctgggaag gatgcagtgg cctcagtagt gtacactgtg gtcattccca tgctgaaccc cttcatctat agcctgagga acagggacat caagagggca ctgtggggga ttataagcat aacagcttaa <210> 1016 <211> 309 <212> PRT <213> Canis familiaris

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<400> 1016 Ser Glu Phe Leu 10 Leu Leu 15 Gly Met 1 Glu Pro Gln Asn 5 Leu Thr Ser Val Leu Ser Asp Asp Pro Glu Leu Gln Pro Leu Leu Phe Gly Leu Leu Leu 20 25 30 Thr Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60

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Met Leu Val Asn Ile Gln Thr His Ser Lys Tyr Ile Thr Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Met Ser Phe Tyr Phe Leu Phe Gly Cys Leu Asp Asn 100 105 110 Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Asn Tyr Pro Ile Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Leu Ser Phe Phe Ser Ser Leu Leu Glu Ser Gln Ile His Cys 145 150 155 160 Leu Met Val Ser Gln Leu Thr Phe Cys Thr Asp Val Glu Ile His His 165 170 175 Phe Phe Cys Asp Ala Pro Gln Leu Leu His Leu Ala Cys Ser Tyr Thr 180 185 190 Ser Ile Asn Thr Ile Leu Ile Tyr Phe Ile Gly Ala Ile Phe Gly Gly 195 200 205 Ile Pro Leu Ser Gly Ile Leu Cys Ser Tyr Ser Arg Ile Ala Ser Ser 210 215 220 Ile Leu Arg Val Pro Thr Thr Gly Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Cys Leu Phe Tyr Gly Thr Gly Leu 245 250 255 Gly Val Tyr Leu Gly Ser Ser Ile Ser Pro Ser Pro Gly Lys Asp Ala 260 265 270 Val Ala Ser Val Val Tyr Thr Val Val Ile Pro Met Leu Asn Pro Phe

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275 280 285

Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Trp Gly Ile 290 295 300

Ile Ser Ile Thr Ala 305 <210> 1017 <211> 909 <212> DNA <213> Canis familiaris <400> 1017 atggaaccaa gaaatcaaac aagtgtttca gaatttttac tcctgggatt ttctcaagac 60 tcagtgcatc agcccattct atttgggcta ttcttgtcca tgtacctggt caccgtgctt 120 gggaacctac tcatcatcct ggccatcacc tctgactccc acctccacac ccccatgtac 180 ttcttcctct ccaacttgtc ctttgctgac atcagtttca cctccaccac agtccctaag 240 atgctggtga acatccaaac acagagcaaa tccatcacct atgcaggctg catcacccag 300 atgtattttt ttatggtttt tggaggcatg gacactttcc tccttactgt gatggcctat 360 gaccggtttg tggccatctg tcaccccttg cactacacag tcatcatgaa tccacagctc 420 tgtggcctcc tggttcttgt gtcctggttc atcagcttct catactccct gatccagagt 480 ttgttgatgt tgcggctgtc tttctgcacc aactgggtaa ttccacactt ttactgtgaa 540 cttgctcagg ccctcaccct tgcctgttca gacacattgg tcaatcatat cttgcaatat 600 atggtgactg cccttcttgg cattgttccc ttctcaggga tccttttctc ctatactcgg 660 attgcctcct caatcctgag aatcccatca gctaatggga agtataagta taaggcattt 720 tccacctgtg cgtctcacct ctccgtggtt tctttattct atgggacagg gcttggtgtg 780 tatctcagtt ctgatgtatc ttcctggaga ggcatgattg cctcggtgat gtacactgtg 840 gtcaccccaa tgctgaaccc cttcatctac agcctacgga acagggacat gaagagggct 900 ctacaaaaa 909 <210> 1018 <211> 303

Page 1142

069269_0225_SL.TXT <212> PRT <213> Canis familiaris <400> 1018

Met 1 Glu Pro Arg Asn 5 Gln Thr Phe Ser Gln Asp 20 Ser Val His Ser Met Tyr 35 Leu Val Thr Val Ile Thr 50 Ser Asp Ser His Leu 55 Asn 65 Leu Ser Phe Ala Asp 70 Ile Met Leu Val Asn Ile 85 Gln Thr Cys Ile Thr Gln 100 Met Tyr Phe Phe Leu Leu 115 Thr Val Met Ala Pro Leu 130 His Tyr Thr Val Ile 135 Val 145 Leu Val Ser Trp Phe 150 Ile Leu Leu Met Leu Arg 165 Leu Ser Phe Tyr Cys Glu 180 Leu Ala Gln

Ser Val Ser 10 Glu Phe Leu Leu Leu 15 Gly Gln Pro 25 Ile Leu Phe Gly Leu 30 Phe Leu Leu 40 Gly Asn Leu Leu Ile 45 Ile Leu Ala His Thr Pro Met Tyr 60 Phe Phe Leu Ser Ser Phe Thr Ser 75 Thr Thr Val Pro Lys 80 Gln Ser Lys 90 Ser Ile Thr Tyr Ala 95 Gly Phe Met 105 Val Phe Gly Gly Met 110 Asp Thr Tyr 120 Asp Arg Phe Val Ala 125 Ile Cys His Met Asn Pro Gln Leu 140 Cys Gly Leu Leu Ser Phe Ser Tyr 155 Ser Leu Ile Gln Ser 160 Phe Cys Thr 170 Asn Trp Val Ile Pro 175 His Ala Leu 185 Thr Leu Ala Cys Ser 190 Asp Thr

Page 1143

Leu Val Asn 195 His Ile Leu Gln 069269_0225_SL.TXT Tyr Met Val Thr Ala Leu 200 205 Leu Gly Ile Val Pro Phe Ser Gly Ile Leu Phe Ser Tyr Thr Arg Ile Ala Ser Ser 210 215 220 Ile Leu Arg Ile Pro Ser Ala Asn Gly Lys Tyr Lys Tyr Lys Ala Phe 225 230 235 240 Ser Thr Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr 245 250 255 Gly Leu Gly Val Tyr Leu Ser Ser Asp Val Ser Ser Trp Arg Gly Met 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Arg Ala Leu Gln Lys 290 295 300

<210> 1019 <211> 939 <212> DNA <213> Canis familiaris <400> 1019 atgggagcag gaaaccagac agaagtatca gtattcctcc ttctgggctt ctcagaagat 60 ccagaactgc agcctctcct ctttggcttg ttcctgtcca tgttcctggt gactgtactg 120 ggaaatctgc tcatcatcct ggctatcctt tctgattccc acctccacac ccccatgtac 180 ttcttcctct ccaacctgtc ttttgttgac atctgtttca tctccaccac tgtcccgaag 240 atgctgctaa acatccaggt acacagcaaa gacatttcct atataggatg catcactcag 300 gtatatttct ttatgatttt tgctggaatg gatgatttcc tcttgactgt gatggcctat 360 gaccggtttg tggccatctg ccaccctctg cactatacca tcatcatgaa cccacgactc 420 tgtgtcctcc tggttctgat ttgttggctc accattttct gggtctccct gattcatatt 480 ctaatggtag ggcagctgac cttctgtaca ggcactgaac ttccacattt cttctgtgaa 540

Page 1144

069269_0225_SL.TXT ctggctcaga ttctcaaggt ggcctgctct gacaccctca tcaataacat ctgcttgtat gttgccactg ctctgctgtg tgtttttcct ctcactggga ttcttttctc ttactctcag atcgtctcct ccttaatgag gatgtcttcc actgagggca agtataaagc attttccact tgtgggtctc acctttctgt ggtctccttg ttctatggta caagcctggg ggtctatctc acttctgctg tgacccattc ttcccagaga agctcagttg catcagtgat gtacactgtg gtcaccccca tgctgaaccc ctttatctac agcctgagga acaaggatgt gaagggcgcc ctgcgaaggc tcctcaacag agcagcctca tgtccatga

600

660

720

780

840

900

939 <210> 1020 <211> 312 <212> PRT <213> Canis familiaris <400> 1020

Met Gly Ala Gly Asn Gln Thr Glu Val Ser Val Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Glu Asp Pro Glu Leu Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Phe Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Leu Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Val His Ser Lys Asp Ile Ser Tyr Ile Gly 85 90 95 Cys Ile Thr Gln Val Tyr Phe Phe Met Ile Phe Ala Gly Met Asp Asp 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125

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Pro Leu His Tyr Thr Ile Ile Met Asn Pro Arg Leu Cys Val Leu Leu 130 135 140 Val Leu Ile Cys Trp Leu Thr Ile Phe Trp Val Ser Leu Ile His Ile 145 150 155 160 Leu Met Val Gly Gln Leu Thr Phe Cys Thr Gly Thr Glu Leu Pro His 165 170 175 Phe Phe Cys Glu Leu Ala Gln Ile Leu Lys Val Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Cys Leu Tyr Val Ala Thr Ala Leu Leu Cys Val 195 200 205 Phe Pro Leu Thr Gly Ile Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser 210 215 220 Leu Met Arg Met Ser Ser Thr Glu Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Ser Leu 245 250 255 Gly Val Tyr Leu Thr Ser Ala Val Thr His Ser Ser Gln Arg Ser Ser 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Arg Leu 290 295 300 Leu Asn Arg Ala Ala Ser Cys Pro 305 310

<210> 1021 <211> 939 <212> DNA

Page 1146

069269_0225_SL.TXT <213> Canis familiaris <400> 1021 atggaagcag gaaatctaac aggaatttta gagttcatcc tccttgggtt ctctgaggat 60 ccagaactac aacccttcat atttgggcta ttcctgtgta tgttcctggt cactgtgctt 120 gggaacctgc tcatcatcct ggccatctgc tctgaccccc acctccatac ccccatgtac 180 ttcttcctct ccaatctgtc gttggttgac atctgtttca gcaccaccat agtgcccaag 240 atgctggtga acatccacac agagaacaaa gccatctcct acatggactg cctcacgcag 300 gtatattttt ccatgttttt tcccatccta gacactctac tccttactgt aatggcctat 360 gaccggtttg tggccatctg ccaccccctg cactacacag tcatcatgag cccacgcctc 420 tgtggcctgt tggtttttgc tacctggttt gttggtatca tgacatccct tcttcatatc 480 tctctgatga ggcacctgag cttctgcaga gaccttgaaa ttccacattt cttctgtgaa 540 ctgacacaga ttctcaagtt ggcctgctct gatacctttc tgaacagcac gttgatatac 600 tttatgactg gtgtgctggg tgtttttccc cttgttggta tccttttctc ctactcacag 660 attgcttcat ctataaggaa gatgtcttca tctgggggaa agcaaaaagc attttccacc 720 tgtgggtctc acctctcagt tgtttcttta ttttatggga caggtgttgg ggtatacttc 780 acttctgcag taactcactc cccccagaaa gtctcagtgg cttcagtgat gtacactgtg 840 gtcaccccca tgctgaaccc cttcatctac agcctgagga acaaggatgt gaagggggca 900 ctgggaagcc ttctcagtag agtgacctct tgtctgtga 939 <210> 1022 <211> 312 <212> PRT <213> Canis familiaris

<400> 1022 Leu Thr Gly Ile Leu Glu Phe Ile Leu Leu Gly Met 1 Glu Ala Gly Asn 5 10 15 Phe Ser Glu Asp Pro Glu Leu Gln Pro Phe Ile Phe Gly Leu Phe Leu 20 25 30 Cys Met Phe Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45

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Ile Cys 50 Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 55 60 Asn Leu Ser Leu Val Asp Ile Cys Phe Ser Thr Thr Ile Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile His Thr Glu Asn Lys Ala Ile Ser Tyr Met Asp 85 90 95 Cys Leu Thr Gln Val Tyr Phe Ser Met Phe Phe Pro Ile Leu Asp Thr 100 105 110 Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Ser Pro Arg Leu Cys Gly Leu Leu 130 135 140 Val Phe Ala Thr Trp Phe Val Gly Ile Met Thr Ser Leu Leu His Ile 145 150 155 160 Ser Leu Met Arg His Leu Ser Phe Cys Arg Asp Leu Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Thr Gln Ile Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Ser Thr Leu Ile Tyr Phe Met Thr Gly Val Leu Gly Val 195 200 205 Phe Pro Leu Val Gly Ile Leu Phe Ser Tyr Ser Gln Ile Ala Ser Ser 210 215 220 Ile Arg Lys Met Ser Ser Ser Gly Gly Lys Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Gly Val 245 250 255

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Gly Val Tyr Phe Thr Ser Ala Val Thr His Ser Pro Gln Lys Val Ser 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Gly Ser Leu 290 295 300 Leu Ser Arg Val Thr Ser Cys Leu

305 310 <210> 1023 <211> 942 <212> DNA <213> Canis familiaris <400> 1023 atgggggatg tgaatcaatc agtgacctct gacttcgttc tggtgggcct cttcagtcac tcagggtcac gtcagctact cttctccctg gtggctgcca cgtttaccat gggcctcctg ggcaacacca ttctgctctt cgtgatccgt acagactccc ggctccacac acccatgtac tttctgctca gccagctctc tctgtttgat gttggcttcc ctctggtcac catccccaag atggcatccg actttctgca gggagacggg tccatctcct tcgggggctg cgcagctcaa atattcttcc tgactctgat gggcgtggct gagggcatcc tgttggccct catgtcctat gaccgctatg ttgccgtgtg tcaccctctg cagtatcccg tgctcatgag gcgccaggtg tgcttgctca tggtgggctc ttcctggcta gcaggggtgc tcaacgcctc cgtccagacc tccatcactc tgcacttccc ctactgcgcc tcccgcatcg tggaccactt cttctgcgag gtgccagccc tgctgaaact ctcctgcgca gacacctcgg cctacgagtt ggcgctgtcc acctcggggg tgctgatcct tgtgcttcca cttttcctca ttgccacttc ctacggccac gtgttggggg ccgttatacg catgcactca gaggaggccc gaaacaaagc cttcaccacc tgttcctcgc acatcacagt agtgggactc ttttacggag cagctgtgtt catgtacatg gtgccgggtg cctaccacag cccacaccag gacaatgtgg tctccctgtt ctatagcctt

120

180

240

300

360

420

480

540

600

660

720

780

840

Page 1149

900

942

069269_0225_SL.TXT gtcaccccca cactcaatcc ccttatctac agtctgagga accgggaggt gcggatggct ctggtcaaag tgctcagcag aactgggctc aggccaaagt ga <210> 1024 <211> 313 <212> PRT <213> Canis familiaris <400> 1024

Met Gly Asp Val Asn Gln Ser Val Thr Ser Asp Phe Val Leu Val Gly 1 5 10 15 Leu Phe Ser His Ser Gly Ser Arg Gln Leu Leu Phe Ser Leu Val Ala 20 25 30 Ala Thr Phe Thr Met Gly Leu Leu Gly Asn Thr Ile Leu Leu Phe Val 35 40 45 Ile Arg Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Phe Asp Val Gly Phe Pro Leu Val Thr Ile Pro Lys 65 70 75 80 Met Ala Ser Asp Phe Leu Gln Gly Asp Gly Ser Ile Ser Phe Gly Gly 85 90 95 Cys Ala Ala Gln Ile Phe Phe Leu Thr Leu Met Gly Val Ala Glu Gly 100 105 110 Ile Leu Leu Ala Leu Met Ser Tyr Asp Arg Tyr Val Ala Val Cys His 115 120 125 Pro Leu Gln Tyr Pro Val Leu Met Arg Arg Gln Val Cys Leu Leu Met 130 135 140 Val Gly Ser Ser Trp Leu Ala Gly Val Leu Asn Ala Ser Val Gln Thr 145 150 155 160 Ser Ile Thr Leu His Phe Pro Tyr Cys Ala Ser Arg Ile Val Asp His

Page 1150

069269_0225_SL.TXT 165 170

Phe Phe Cys Glu Val Pro Ala Leu Leu Lys 185 Leu Ser Cys Ala 190 180 Ser Ala Tyr Glu Leu Ala Leu Ser Thr Ser Gly Val Leu Ile 195 200 205 Leu Pro Leu Phe Leu Ile Ala Thr Ser Tyr Gly His Val Leu 210 215 220 Val Ile Arg Met His Ser Glu Glu Ala Arg Asn Lys Ala Phe 225 230 235 Cys Ser Ser His Ile Thr Val Val Gly Leu Phe Tyr Gly Ala 245 250 Phe Met Tyr Met Val Pro Gly Ala Tyr His Ser Pro His Gln 260 265 270 Val Val Ser Leu Phe Tyr Ser Leu Val Thr Pro Thr Leu Asn 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Glu Val Arg Met Ala Leu Val 290 295 300 Leu Ser Arg Thr Gly Leu Arg Pro Lys 305 310

175

Asp Thr

Leu Val

Gly Ala

Thr Thr 240

Ala Val 255

Asp Asn

Pro Leu

Lys Val <210> 1025 <211> 648 <212> DNA <213> Canis familiaris <400> 1025 ttcctcagct tccctgcctg cttcctacag atgtacctca tccacagctt gaagccttca tcctggtggt catggcttat gaccgccaag tgaatatctg cactaccctg tcctcatgac cccacagacc agtgctacac tggcagcctg actgccctcc tcccgcccat cccagcagtg gtgcagactt cccacttggc Page 1151 ctcctgctct ccacccactg tgcctggctc ttttgacagc

120

180

240

069269_0225_SL.TXT

actgctcaca tctatcactg cttctgtgac tacttggccg tggtccaggc ctcctgctct 300 gacaccatgc cccagaccct catgggcttc tgcactgcca tggtggtatc cttcctgccc 360 cgtctcctgg cgcttctctc ctatgcccac atcctggcct cggtgcttca catcagctcc 420 caggaaggac gttcaaaagc cttctccacc tgtagctccc acctgctgat ggttggcaca 480 tactgctcat ccattgccat agcctatgtg gcctacaggg ctgacctgcc ccttgatgtc 540 cacatcatgg gcaatgtggt atatgctatt ctcacatctg tcctcagcca tctcatttac 600 atgctgagga acaaggatgt caaagtagcc atcaccagaa tggcatgt 648

<210> 1026 <211> 216 <212> PRT <213> Canis familiaris <400> 1026

Phe Leu Ser Phe Pro Ala Cys Phe Leu Gln Met Tyr Leu Ile His Ser 1 5 10 15 Phe Ser Cys Ser Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg 20 25 30 Gln Val Asn Ile Cys His Pro Leu His Tyr Pro Val Leu Met Thr Pro 35 40 45 Gln Thr Ser Ala Thr Leu Ala Ala Cys Ala Trp Leu Thr Ala Leu Leu 50 55 60 Pro Pro Ile Pro Ala Val Val Gln Thr Ser His Leu Ala Phe Asp Ser 65 70 75 80 Thr Ala His Ile Tyr His Cys Phe Cys Asp Tyr Leu Ala Val Val Gln 85 90 95 Ala Ser Cys Ser Asp Thr Met Pro Gln Thr Leu Met Gly Phe Cys Thr 100 105 110 Ala Met Val Val Ser Phe Leu Pro Arg Leu Leu Ala Leu Leu Ser Tyr

115 120 125

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Ala His Ile Leu Ala Ser Val Leu His Ile Ser Ser Gln Glu Gly Arg 130 135 140

Ser Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu Met Val Gly Thr 145 150 155 160

Tyr Cys Ser Ser Ile Ala Ile Ala Tyr Val Ala Tyr Arg Ala Asp Leu 165 170 175

Pro Leu Asp Val His Ile Met Gly Asn Val Val Tyr Ala Ile Leu Thr 180 185 190

Ser Val Leu Ser His Leu Ile Tyr Met Leu Arg Asn Lys Asp Val Lys 195 200 205

Val Ala Ile Thr Arg Met Ala Cys 210 215 <210> 1027 <211> 501 <212> DNA <213> Canis familiaris <400> 1027

cccactgcat accctgtcct catgacccta cagaccaatg ctacactggc agcctgtgcc 60 tggctcactg ccctcctcct gcccattcca gcagtggtgc agacttccca cttggctttt 120 gacagcactg ctcacatcta tcactgcttc tgtgaccact tggccatggt ccaggcctcc 180 tgctccatgc ccgagaccct catgggcttc tgcattgcca tggtggtatc cttcctgccc 240 cttctcctgg tgcttctctc ctatgcccac atcctggcct cggtgcttcg catcagctcc 300 tgagaaggat gttcaaaagc cttctccacc tgtagctccc acttcctggt agttggcaca 360 tactgctcat ccattgccat agcctatgtg gcctacaggg ctgacctgct ccttgacctc 420 cacatcatgg gtgatgtggt atttgccatt ctcacacctg tcctcaaccc tgtcgtctac 480 atgctgagga acaaggatgt c 501

<210> 1028

Page 1153

069269_0225_SL.TXT <211> 100 <212> PRT <213> Canis familiaris

<400> 1028 Pro Thr Ala Tyr 1 Pro 5 Val Leu Met Thr Leu Gln Thr Asn Ala Thr Leu 10 15 Ala Ala Cys Ala Trp Leu Thr Ala Leu Leu Leu Pro Ile Pro Ala Val 20 25 30 Val Gln Thr Ser His Leu Ala Phe Asp Ser Thr Ala His Ile Tyr His 35 40 45 Cys Phe Cys Asp His Leu Ala Met Val Gln Ala Ser Cys Ser Met Pro 50 55 60 Glu Thr Leu Met Gly Phe Cys Ile Ala Met Val Val Ser Phe Leu Pro 65 70 75 80 Leu Leu Leu Val Leu Leu Ser Tyr Ala His Ile Leu Ala Ser Val Leu 85 90 95

Arg Ile Ser Ser 100 <210> 1029 <211> 951 <212> DNA <213> Canis familiaris <400> 1029

atggaggcca caacctgtaa tggatcactg gatggatcac ctgtcttcta cctggtggga 60 atcccctctc tgccagagac cttcttcctc cctgtgtttt ttattttcct cctcttctat 120 cttcttatcc ttatgggaaa tgtcctgatc ctggtggctg tggtgggaga gcccagcctc 180 cacaagccca tgtacttctt tctgatcaac ctctctactc tggacattct cttcaccaca 240 accaccgtcc ccaagatgct gtccctgttc ctgcttgggg accacttcct cagcttccct 300 gcctgcttat tgcaaatgta cctcttccaa agcttcacat gttcagaagc cttcatcctg 360 gtggtcatgg cctatgaccg ctatgtggct atctgccgcc cactgcacta ccctgtccac 420

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atgaccccac agaccaatgc tgtgctggca gcctgtgcct ggctcactgc cctcctcttg 480 cccatcccag cagtggtcaa gacctcccag atggcatata acaacattgc tcgcatctac 540 cattgtttct gtgatcactt ggctctggtc caggcctcct gctctgacac catgccccag 600 accctcatgg gcttctgcat tgccatggtg gtatccttcc tgccccttct cctggtgctt 660 ctctcctatg cccacatcct ggcctcggtg cttcgcatca gctcccgaga aggacgttca 720 aaagccttct ccacctgtag ctcccacctc ctggtggttg gcacatacta ctcatctatt 780 gccgtagcct atgtggccta cagggctgac ctgccccttg acttccacat catgggcaat 840 gtagcatatg ctattctcac accaattctc aaccctctca tttacactct gagaaacaag 900 gatgtcaaag cagccattac caaaatcaca tgtctcaaga cccagtcttg a 951

<210> 1030 <211> 316 <212> PRT <213> Canis familiaris

<400> 1030 Cys Asn Gly Ser Leu Asp Gly Ser Pro Val Phe Met Glu 1 Ala Thr Thr 5 10 15 Tyr Leu Val Gly Ile Pro Ser Leu Pro Glu Thr Phe Phe Leu Pro Val 20 25 30 Phe Phe Ile Phe Leu Leu Phe Tyr Leu Leu Ile Leu Met Gly Asn Val 35 40 45 Leu Ile Leu Val Ala Val Val Gly Glu Pro Ser Leu His Lys Pro Met 50 55 60 Tyr Phe Phe Leu Ile Asn Leu Ser Thr Leu Asp Ile Leu Phe Thr Thr 65 70 75 80 Thr Thr Val Pro Lys Met Leu Ser Leu Phe Leu Leu Gly Asp His Phe 85 90 95 Leu Ser Phe Pro Ala Cys Leu Leu Gln Met Tyr Leu Phe Gln Ser Phe 100 105 110

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Thr Cys Ser 115 Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr 120 125 Val Ala Ile Cys Arg Pro Leu His Tyr Pro Val His Met Thr Pro Gln 130 135 140 Thr Asn Ala Val Leu Ala Ala Cys Ala Trp Leu Thr Ala Leu Leu Leu 145 150 155 160 Pro Ile Pro Ala Val Val Lys Thr Ser Gln Met Ala Tyr Asn Asn Ile 165 170 175 Ala Arg Ile Tyr His Cys Phe Cys Asp His Leu Ala Leu Val Gln Ala 180 185 190 Ser Cys Ser Asp Thr Met Pro Gln Thr Leu Met Gly Phe Cys Ile Ala 195 200 205 Met Val Val Ser Phe Leu Pro Leu Leu Leu Val Leu Leu Ser Tyr Ala 210 215 220 His Ile Leu Ala Ser Val Leu Arg Ile Ser Ser Arg Glu Gly Arg Ser 225 230 235 240 Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Gly Thr Tyr 245 250 255 Tyr Ser Ser Ile Ala Val Ala Tyr Val Ala Tyr Arg Ala Asp Leu Pro 260 265 270 Leu Asp Phe His Ile Met Gly Asn Val Ala Tyr Ala Ile Leu Thr Pro 275 280 285 Ile Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Ala 290 295 300 Ala Ile Thr Lys Ile Thr Cys Leu Lys Thr Gln Ser

305 310 315

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069269_0225_SL.TXT <210> 1031 <211> 939 <212> DNA <213> Canis familiaris <400> 1031

atggaaacta tagcctgtaa tggatcagag gattcctcac ccatcttcta cctggtgggc 60 attccttctc tgcccaaatc cctctttctt cctatcttct ttgtctttct cttcctttac 120 ctgctcatcc tgctgggaaa tgtcctgatc ctactggctg tggtggcaga gcccagcctc 180 cacaagccca tgtacttctt cctgattaat ctctcagccc tggacatcct tttcaccaca 240 accaccgtcc ccaagatgct gtccctcctc ttacttgggg accgcttcct cagcttccct 300 gcctgcttcc tgcagatgta cctcttccac agcttctcct gctctgaagc cttcatcctg 360 gtggtcatgg cctatgaccg ctatgtggct atctgccgcc cactgcacta ccctgtcctc 420 atgaccccac agaccaatgc tacactggca gcctgtgcct ggctcactgc cctcctcctg 480 cccatcccag cagtggtgca gacttcccac ttggcttttg acagcactgc tcacatctat 540 cactgcttct gtgaccactt ggccgtggtc caggcctcct gctctgacac catgccccag 600 accctcatgg gattctgcat tgccatggtg gtatccttcc tgccccttct cctggtgctt 660 ctctcctatg cccacatcct ggcctcggtg cttcgcatca gctcccgaga aggacgttca 720 aaagccttct ccacctgtag ctcccacctc ctggtggttg gcacatacta ctcatccatt 780 gccatagcct atgtggccta taaggctgac ctgccccttg atttccacat catgggcaat 840 gtggtatatg ctattctcac acctgtcctc aaccctctca tctacacgct gaggaacaag 900 gatgtcaaag cagccatcac cagaatggca tgtctctga 939

<210> 1032 <211> 312 <212> PRT <213> Canis familiaris <400> 1032

Met Glu Thr Ile Ala Cys Asn Gly Ser Glu Asp Ser Ser Pro Ile Phe

1 5 10 15

Tyr Leu Val Gly Ile Pro Ser Leu Pro Lys Ser Leu Phe Leu Pro Ile

Page 1157

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Phe Phe Val 35 Phe Leu Phe Leu Tyr Leu Leu Ile Leu Leu Gly Asn Val 40 45 Leu Ile Leu Leu Ala Val Val Ala Glu Pro Ser Leu His Lys Pro Met 50 55 60 Tyr Phe Phe Leu Ile Asn Leu Ser Ala Leu Asp Ile Leu Phe Thr Thr 65 70 75 80 Thr Thr Val Pro Lys Met Leu Ser Leu Leu Leu Leu Gly Asp Arg Phe 85 90 95 Leu Ser Phe Pro Ala Cys Phe Leu Gln Met Tyr Leu Phe His Ser Phe 100 105 110 Ser Cys Ser Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr 115 120 125 Val Ala Ile Cys Arg Pro Leu His Tyr Pro Val Leu Met Thr Pro Gln 130 135 140 Thr Asn Ala Thr Leu Ala Ala Cys Ala Trp Leu Thr Ala Leu Leu Leu 145 150 155 160 Pro Ile Pro Ala Val Val Gln Thr Ser His Leu Ala Phe Asp Ser Thr 165 170 175 Ala His Ile Tyr His Cys Phe Cys Asp His Leu Ala Val Val Gln Ala 180 185 190 Ser Cys Ser Asp Thr Met Pro Gln Thr Leu Met Gly Phe Cys Ile Ala 195 200 205 Met Val Val Ser Phe Leu Pro Leu Leu Leu Val Leu Leu Ser Tyr Ala 210 215 220 His Ile Leu Ala Ser Val Leu Arg Ile Ser Ser Arg Glu Gly Arg Ser

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225 230 235 240 Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Gly Thr Tyr 245 250 255 Tyr Ser Ser Ile Ala Ile Ala Tyr Val Ala Tyr Lys Ala Asp Leu Pro 260 265 270 Leu Asp Phe His Ile Met Gly Asn Val Val Tyr Ala Ile Leu Thr Pro 275 280 285 Val Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Ala 290 295 300 Ala Ile Thr Arg Met Ala Cys Leu 305 310

<210> 1033 <211> 1032 <212> DNA <213> Canis familiaris <400> 1033 atgggtgaag atggaaatac cagcaccttc aacatctcct acaccaactt cttcctggtg 60 ggcttccctg gattccgaga gtggcgacct ctcctggtcc tgccccttac cttcctatat 120 gtgaccgtca tctcagccaa tgccctggtc atccacacag tggtggccca gcggagcctg 180 catcagccca tgtacatgct catcgccctg ctcctggctg tcaacatttg tgctgccact 240 gccgtgatgc ccaaaatgct ggagggcttt gtgcattatg ctaaccccat atcactgcac 300 agctgcctag cccagatgtt ctttatctac ttcactcttc ttctggacta caatctcctg 360 ctggccatgg ccctagaccg ctatgtcgcc atctgtcacc cactccgcta tactgaccta 420 atgacctctc acctgcttgg tgtgctggcc attcttgccc tgacacagag cctgggagtg 480 gcagtgcctt tggtagtgct aacatcacaa gctcgattct gccggacaat ggtgattcca 540 cacttcacct gtgagtacat tgcactgctg agcatagctt gtggagactt gactttcaac 600 aataggttgg gactggccat gcggttggtc actgtgacct ttgatctcgc cctgctaggg 660 acctcctaca cccgcatcat ttatgctgcc tttcggatct cttctggggg agcccgagct 720

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aaggccttgc acacatgtgg ctcccactta ctagtcatcc tcactatcta cctctctggt 780 ctctccactt ccattgtttt ccgggtagcc aagactgtgt ctcaggatgt ccagaacctg 840 ctcagtgcca tctacttgct gctcccaggc accttgaatc ctgtcattta tggggtgagg 900 accagggaga tccggcaaca tgtggaaaag atgctcttta gcaagatatc agcccaggaa 960 gttggggaga agccagagag aatgcaaaat atgaggggaa attgccaggg tgagaggact 1020 ttatcaactt ga 1032

<210> 1034 <211> 343 <212> PRT <213> Canis familiaris

<400> 1034 Asn Thr Ser Thr Phe Asn Ile Ser Tyr Thr Asn Met 1 Gly Glu Asp Gly 5 10 15 Phe Phe Leu Val Gly Phe Pro Gly Phe Arg Glu Trp Arg Pro Leu Leu 20 25 30 Val Leu Pro Leu Thr Phe Leu Tyr Val Thr Val Ile Ser Ala Asn Ala 35 40 45 Leu Val Ile His Thr Val Val Ala Gln Arg Ser Leu His Gln Pro Met 50 55 60 Tyr Met Leu Ile Ala Leu Leu Leu Ala Val Asn Ile Cys Ala Ala Thr 65 70 75 80 Ala Val Met Pro Lys Met Leu Glu Gly Phe Val His Tyr Ala Asn Pro 85 90 95 Ile Ser Leu His Ser Cys Leu Ala Gln Met Phe Phe Ile Tyr Phe Thr 100 105 110 Leu Leu Leu Asp Tyr Asn Leu Leu Leu Ala Met Ala Leu Asp Arg Tyr 115 120 125

Page 1160

Val Ala 130 Ile Cys His Pro Leu 135 069269_0225_SL.TXT Arg Tyr Thr Asp Leu Met 140 Thr Ser His Leu Leu Gly Val Leu Ala Ile Leu Ala Leu Thr Gln Ser Leu Gly Val 145 150 155 160 Ala Val Pro Leu Val Val Leu Thr Ser Gln Ala Arg Phe Cys Arg Thr 165 170 175 Met Val Ile Pro His Phe Thr Cys Glu Tyr Ile Ala Leu Leu Ser Ile 180 185 190 Ala Cys Gly Asp Leu Thr Phe Asn Asn Arg Leu Gly Leu Ala Met Arg 195 200 205 Leu Val Thr Val Thr Phe Asp Leu Ala Leu Leu Gly Thr Ser Tyr Thr 210 215 220 Arg Ile Ile Tyr Ala Ala Phe Arg Ile Ser Ser Gly Gly Ala Arg Ala 225 230 235 240 Lys Ala Leu His Thr Cys Gly Ser His Leu Leu Val Ile Leu Thr Ile 245 250 255 Tyr Leu Ser Gly Leu Ser Thr Ser Ile Val Phe Arg Val Ala Lys Thr 260 265 270 Val Ser Gln Asp Val Gln Asn Leu Leu Ser Ala Ile Tyr Leu Leu Leu 275 280 285 Pro Gly Thr Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Arg Glu Ile 290 295 300 Arg Gln His Val Glu Lys Met Leu Phe Ser Lys Ile Ser Ala Gln Glu 305 310 315 320 Val Gly Glu Lys Pro Glu Arg Met Gln Asn Met Arg Gly Asn Cys Gln 325 330 335

Page 1161

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Gly Glu Arg Thr Leu Ser Thr 340 <210> 1035 <211> 945 <212> DNA <213> Canis familiaris <400> 1035

atgacagtgt tcaatatcac cacaacccat ccagcttcct tcctgctggt aggaattcca 60 ggtttggagc aattgcatgt ctggatctcc attccattct gctttgccta tactctggcc 120 ctgctaggca actgcaccct tctcttcatt attcaggctg atgcagccct ccatgagccc 180 atgtacttct ttctggccat gttggcagcc attgacctgg tcctctcttc tacaacactt 240 cccaaaatgc tggctatttt ttggttcaga gatcgggaga tcagcttcta tggctgtctg 300 gtccagatgt tctttctcca ctccttctct atcatggagt cagcagtgct gctggccatg 360 gcctttgacc gctatgtggc catctgcaag ccattgcact acaccacagt cctgactagg 420 cccctgatca ccaagattgg catggcagct gtggctcggg ctgtgacatt aatgactccg 480 ctcccctttc tgctcagacg cttccactac tgccgaggca ccatgattgc ccactgctac 540 tgtgagcata tggctgtggt gaggctggcc tgtggggata ctcgcttcaa caatatctat 600 ggcattgctg tggccatgtt tatagtggtg ttggacctgc tgtttgttat cttgtcttac 660 atcttcatcc ttcgggcagt tttacagctt gcctctcaag aggcccgcta caaggccttt 720 gggacatgtg tatctcacat aggtgccatc ttatctacct acacacctgt ggtcatctcc 780 tcagtcatgc atcgtgtggc tcgccgggct gcccctcatg tccacatact acttgctatt 840 ttctatcttc tttttccgcc catgatcaat cccatcatct atggtgtcaa gaccaagcag 900 attcgtgatc atgtgctcaa tctgttccag agaaagaaag tgtag 945

<210> 1036 <211> 314 <212> PRT <213> Canis familiaris <400> 1036

Met Thr Val Phe Asn Ile Thr Thr Thr His Pro Ala Ser Phe Leu Leu 1 5 10 15

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Val Gly Ile Pro 20 Gly Leu Glu Gln Leu His Val Trp Ile Ser Ile Pro 25 30 Phe Cys Phe Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu 35 40 45 Phe Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Met Tyr Phe Phe 50 55 60 Leu Ala Met Leu Ala Ala Ile Asp Leu Val Leu Ser Ser Thr Thr Leu 65 70 75 80 Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile Ser Phe 85 90 95 Tyr Gly Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser Ile Met 100 105 110 Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Lys Pro Leu His Tyr Thr Thr Val Leu Thr Arg Pro Leu Ile Thr 130 135 140 Lys Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met Thr Pro 145 150 155 160 Leu Pro Phe Leu Leu Arg Arg Phe His Tyr Cys Arg Gly Thr Met Ile 165 170 175 Ala His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Cys Gly 180 185 190 Asp Thr Arg Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met Phe Ile 195 200 205 Val Val Leu Asp Leu Leu Phe Val Ile Leu Ser Tyr Ile Phe Ile Leu 210 215 220

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Arg 225 Ala Val Leu Gln Leu Ala Ser Gln Glu Ala Arg Tyr Lys Ala Phe 230 235 240 Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ser Thr Tyr Thr Pro 245 250 255 Val Val Ile Ser Ser Val Met His Arg Val Ala Arg Arg Ala Ala Pro 260 265 270 His Val His Ile Leu Leu Ala Ile Phe Tyr Leu Leu Phe Pro Pro Met 275 280 285 Ile Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp His 290 295 300 Val Leu Asn Leu Phe Gln Arg Lys Lys Val 305 310

<210> 1037 <211> 303 <212> DNA <213> Canis familiaris <400> 1037 tctgtccggg tcaacaagat atatggtctt tttattgcct tcagtatctt ggggtttgac 60 acaatcttca tcaccttgtc ttatgttcag atctttatca ctgtgcttca attgcctcag 120 aaggaggcac gattcaaggc ctttaatacc tgccttgtcc acatctgtgt ctttttacag 180 ttctacctcc ttgccttctt ctccttctta acacataggt ttgtttctta cataccacct 240 tatattcata tcctcttatc aagcctttac ctgttagtcc ctcctttcct caacccgata 300 gtc 303 <210> 1038 <211> 101 <212> PRT <213> Canis familiaris <400> 1038

Ser Val Arg Val Asn Lys Ile Tyr Gly Leu Phe Ile Ala Phe Ser Ile 1 5 10 15

Page 1164

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Leu Gly Phe Asp Thr Ile Phe Ile Thr Leu Ser Tyr Val Gln Ile Phe 20 25 30 Ile Thr Val Leu Gln Leu Pro Gln Lys Glu Ala Arg Phe Lys Ala Phe 35 40 45 Asn Thr Cys Leu Val His Ile Cys Val Phe Leu Gln Phe Tyr Leu Leu 50 55 60 Ala Phe Phe Ser Phe Leu Thr His Arg Phe Val Ser Tyr Ile Pro Pro 65 70 75 80 Tyr Ile His Ile Leu Leu Ser Ser Leu Tyr Leu Leu Val Pro Pro Phe 85 90 95 Leu Asn Pro Ile Val

100

<210> 1039 <211> 936 <212> DNA <213> Canis familiaris <400> 1039 atgtccatct ccaacattac aatcttcatg ccttctgtgt tgacactaat agggatccca 60 ggcctagagt ctgtgcagtg ctggattggg attccattct gtgccatgta tcactttgct 120 atgattggaa atttcttgct tctgatcatc atcaaatcag agcgcagcct ccatgagccc 180 atgtatattt tcttaggcat gttaggagtc acagatattg tacctggcac aggcattgtg 240 cccaagatgc ttggaatttt ttgactacat gtaccagaga tttattttga ttcctgcttg 300 cttcaaatgg ggctcatcca cacatttgag tgcatagagt caggcatcct ccttgccatg 360 gccctggacc gttatgtggc catctgttat ccactcaaac acagtggcat cttcacccac 420 cagctggtgg cccaaatagg ggctatggta acactcaggg ctgccattct ggtagcccca 480 tctttagcac tcataaagtg tcggtttcaa ttttatcata caaccaccat ctcccactcc 540 tactgtgagc atatggccat tgtgaaactg gctgcagaaa atgtgcgggt caacaaaatc 600

Page 1165

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tatgacttgt ttgtggcatt tgctgttgca gggttcgacc tcaccttcat cactatgtcc 660 tacatacaga tcttcttcac ggtttttcgt ttgccccaga aggagcccca cttgaaagca 720 ttcagtacct gcatcgccca catctgcgtt ttcctccagc tctacttcct tgccttcttc 780 tccttcttca ctcataggtt tggtactcat gtccctcctt atatccatat cctcttttct 840 agcctctact tgctggtccc cccatttctt aatccacttg tctatggtgc caagaccaag 900 caaatccgca ttcacgtggt aaagatgttc tgttct 936

<210> 1040 <211> 210 <212> PRT <213> Canis familiaris

<400> 1040 Thr Phe Glu Cys Ile Glu Ser Gly Ile Leu Leu Met 1 Gly Leu Ile His 5 10 15 Ala Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Tyr Pro Leu Lys His 20 25 30 Ser Gly Ile Phe Thr His Gln Leu Val Ala Gln Ile Gly Ala Met Val 35 40 45 Thr Leu Arg Ala Ala Ile Leu Val Ala Pro Ser Leu Ala Leu Ile Lys 50 55 60 Cys Arg Phe Gln Phe Tyr His Thr Thr Thr Ile Ser His Ser Tyr Cys 65 70 75 80 Glu His Met Ala Ile Val Lys Leu Ala Ala Glu Asn Val Arg Val Asn 85 90 95 Lys Ile Tyr Asp Leu Phe Val Ala Phe Ala Val Ala Gly Phe Asp Leu 100 105 110 Thr Phe Ile Thr Met Ser Tyr Ile Gln Ile Phe Phe Thr Val Phe Arg 115 120 125

Leu Pro Gln

Lys Glu Pro His Leu

Lys Ala

Phe Ser Thr Cys Ile Ala

Page 1166

130 135 069269_0225_SL.TXT 140 His Ile Cys Val Phe Leu Gln Leu Tyr Phe Leu Ala Phe Phe Ser Phe 145 150 155 160 Phe Thr His Arg Phe Gly Thr His Val Pro Pro Tyr Ile His Ile Leu 165 170 175 Phe Ser Ser Leu Tyr Leu Leu Val Pro Pro Phe Leu Asn Pro Leu Val 180 185 190 Tyr Gly Ala Lys Thr Lys Gln Ile Arg Ile His Val Val Lys Met Phe 195 200 205

Cys Ser 210 <210> 1041 <211> 984 <212> DNA <213> Canis familiaris <400> 1041

atgaagtctc accatgacat tttcaatgcg tccattgcat tcacacctgc aacattcact 60 cttgctggca ttccagggct agaggcagaa catatctgga tatccatccc tttctgcctg 120 atatacatca tcatcttcct aggaaatggc atcattcttc atatcatccg gattgaccct 180 gctttgcacc aacccatgta ctcctttttg gccacgctgg cctttgttga acttggggtc 240 tctgcttcca ccatgcccac tgtgctaggc attttcctct gtggaattaa tgaaatcagt 300 tttggtggtt gcctgttcca gatgttttcc atgcattctt ttaccataat ggagtcaggt 360 gtccttctca ctatgtctgt agaccgtttt gtggccatct acagccccct gcgctacaca 420 accatcctga caattccccg catcattggg atgggtgtca tcattgcctt acgaagtgtg 480 gtgctcatgt tcccactgct cttcctcctg aagggcctgc ctttctgtgg tcacaatact 540 ctcacacact cttactgtct ccattcagat ctaatcaaat tgccctgtgg agacactaga 600 cccaatagca tcctgggttt gtttgtcatt acctccacat ttgggctgga ctcactgctc 660 attgtagttt cttatatgtt gattcttcac actgtactgg gaatagcttc tggagctggg 720

Page 1167

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cagtggaagg cactcaacac atgcgtgtca cacatctgtg ctgttctggt gtactacgtg 780 cccatgatta gcctctcctt gctgcatcgc tttgggggac acttacctcc actccttcag 840 actgtcatgg ccaatgccta cctcttcttc ccacctgtgg tcaaccccat tgtgtatagt 900 atgaaaacaa aagaaattcg caatagcatt gttcgtatac tgcctagaaa gaggcatgaa 960 gtctcaagac agataatacc ctaa 984

<210> 1042 <211> 327 <212> PRT <213> Canis familiaris <400> 1042

Met 1 Lys Ser His His Asp Ile Phe Asn Ala Ser Ile Ala Phe Thr Pro 5 10 15 Ala Thr Phe Thr Leu Ala Gly Ile Pro Gly Leu Glu Ala Glu His Ile 20 25 30 Trp Ile Ser Ile Pro Phe Cys Leu Ile Tyr Ile Ile Ile Phe Leu Gly 35 40 45 Asn Gly Ile Ile Leu His Ile Ile Arg Ile Asp Pro Ala Leu His Gln 50 55 60 Pro Met Tyr Ser Phe Leu Ala Thr Leu Ala Phe Val Glu Leu Gly Val 65 70 75 80 Ser Ala Ser Thr Met Pro Thr Val Leu Gly Ile Phe Leu Cys Gly Ile 85 90 95 Asn Glu Ile Ser Phe Gly Gly Cys Leu Phe Gln Met Phe Ser Met His 100 105 110 Ser Phe Thr Ile Met Glu Ser Gly Val Leu Leu Thr Met Ser Val Asp 115 120 125 Arg Phe Val Ala Ile Tyr Ser Pro Leu Arg Tyr Thr Thr Ile Leu Thr

130 135 140

Page 1168

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Ile 145 Pro Arg Ile Ile Gly 150 Met Gly Val Ile Ile Ala Leu Arg Ser Val 155 160 Val Leu Met Phe Pro Leu Leu Phe Leu Leu Lys Gly Leu Pro Phe Cys 165 170 175 Gly His Asn Thr Leu Thr His Ser Tyr Cys Leu His Ser Asp Leu Ile 180 185 190 Lys Leu Pro Cys Gly Asp Thr Arg Pro Asn Ser Ile Leu Gly Leu Phe 195 200 205 Val Ile Thr Ser Thr Phe Gly Leu Asp Ser Leu Leu Ile Val Val Ser 210 215 220 Tyr Met Leu Ile Leu His Thr Val Leu Gly Ile Ala Ser Gly Ala Gly 225 230 235 240 Gln Trp Lys Ala Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu 245 250 255 Val Tyr Tyr Val Pro Met Ile Ser Leu Ser Leu Leu His Arg Phe Gly 260 265 270 Gly His Leu Pro Pro Leu Leu Gln Thr Val Met Ala Asn Ala Tyr Leu 275 280 285 Phe Phe Pro Pro Val Val Asn Pro Ile Val Tyr Ser Met Lys Thr Lys 290 295 300 Glu Ile Arg Asn Ser Ile Val Arg Ile Leu Pro Arg Lys Arg His Glu 305 310 315 320 Val Ser Arg Gln Ile Ile Pro

<210> 1043 <211> 972

Page 1169

325

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 1043

atgctgcagg agatggctcc tttctcttac aaccacacca atacccagga tatgtggtat 60 gtcctgattg gaatcccagg gctggaagat tctcacccct ggatctccat ccctatctgt 120 tcgatgtacg tgttggctgt cataggcaac agcttcttga tcttcctgat tgtgactgag 180 cgcagtctcc acgagcccat gtattttttc ctttccatgc tggccttggc agatgtgctg 240 ctctccacag ccacggcccc caagatgctg gccatcttct ggttccagtc catggatata 300 tccttcggta gctgtgtatc tcagatgttc ttcatacatt tcatctttgt ggcagaatct 360 gctattctcc tggccatggc atttgaccgc tatgtggcca tctgtcaccc cctgagatac 420 accaccatct taacctcctc agccactggg aagattggca tagcagctgt ggtcaggagc 480 tttttcatct gccttccatt catcttcctg gtttaccgac ttaggtactg tgggagaaac 540 atcattcccc actcctactg tgagcacatg ggcattgcca gattggcatg tgacagtatc 600 aaggtcaaca tcatctatgg cctgactgtg gccctactgt ctacaggact ggatattgtg 660 ttcatcatta tgtcgtacac catgatcctt tgcacagtgt ttcagatacc ttcctgggct 720 gccagattca aggccctcaa cacatgtgct tcccacatct gtgtcatcct tatgttctat 780 gccccagcat tcttttcatt ttttgcccat cgttttgggg gtaaaaccat ccctcaccac 840 atccacatcc tggtagccaa tctctatgtg gttgttcccc ctatgctaaa ccccatcatt 900 tatggggtga agaccaaaca gattcaagac cgagtaacat tgcttttctc cttcatcagc 960 acatgttgtt aa 972

<210> 1044 <211> 323 <212> PRT <213> Canis familiaris <400> 1044

Met Leu Gln Glu Met Ala Pro Phe Ser Tyr Asn His Thr Asn Thr Gln 1 5 10 15

Asp Met Trp Tyr Val Leu Ile Gly Ile Pro Gly Leu Glu Asp Ser His 20 25 30

Page 1170

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Pro Trp Ile 35 Ser Ile Pro Ile Cys Ser Met Tyr Val Leu Ala Val Ile 40 45 Gly Asn Ser Phe Leu Ile Phe Leu Ile Val Thr Glu Arg Ser Leu His 50 55 60 Glu Pro Met Tyr Phe Phe Leu Ser Met Leu Ala Leu Ala Asp Val Leu 65 70 75 80 Leu Ser Thr Ala Thr Ala Pro Lys Met Leu Ala Ile Phe Trp Phe Gln 85 90 95 Ser Met Asp Ile Ser Phe Gly Ser Cys Val Ser Gln Met Phe Phe Ile 100 105 110 His Phe Ile Phe Val Ala Glu Ser Ala Ile Leu Leu Ala Met Ala Phe 115 120 125 Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Thr Thr Ile Leu 130 135 140 Thr Ser Ser Ala Thr Gly Lys Ile Gly Ile Ala Ala Val Val Arg Ser 145 150 155 160 Phe Phe Ile Cys Leu Pro Phe Ile Phe Leu Val Tyr Arg Leu Arg Tyr 165 170 175 Cys Gly Arg Asn Ile Ile Pro His Ser Tyr Cys Glu His Met Gly Ile 180 185 190 Ala Arg Leu Ala Cys Asp Ser Ile Lys Val Asn Ile Ile Tyr Gly Leu 195 200 205 Thr Val Ala Leu Leu Ser Thr Gly Leu Asp Ile Val Phe Ile Ile Met 210 215 220 Ser Tyr Thr Met Ile Leu Cys Thr Val Phe Gln Ile Pro Ser Trp Ala 225 230 235 240

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Ala Arg Phe Lys Ala Leu Asn Thr Cys Ala Ser His Ile Cys Val Ile 245 250 255 Leu Met Phe Tyr Ala Pro Ala Phe Phe Ser Phe Phe Ala His Arg Phe 260 265 270 Gly Gly Lys Thr Ile Pro His His Ile His Ile Leu Val Ala Asn Leu 275 280 285 Tyr Val Val Val Pro Pro Met Leu Asn Pro Ile Ile Tyr Gly Val Lys 290 295 300 Thr Lys Gln Ile Gln Asp Arg Val Thr Leu Leu Phe Ser Phe Ile Ser 305 310 315 320

Thr Cys Cys <210> 1045 <211> 972 <212> DNA <213> Canis familiaris <400> 1045 atgctgcagg agatggcccc tttctcttac aaccacacca atacccagga tatgtggtat gtcctgattg gaatcccagg gctggaagat tctcacccct ggatctccat ccctatctgt tcgatgtacg tgttggctgt cataggcaac agcttcttga tcttcctgat tgtgactgag cgcagtctcc acgagcccat gtattttttc ctttccatgc tggcctcggc agatgtgctg ctctccacag ccacggcccc caagatgctg gccatcttct ggttccagtc catggatata tccttcggta gctgtgtatc tcagatgttt ttcatacatt tcatctttgc gacagaatct gctattctcc tggccatggc atttgaccgc tatgtggcca tctgtcaccc cctgagatac accaccatct taacctcctc agccactggg aagattggca tagcagctgt ggtcaggagc tttttcatct gccttccatt catcttcctg gtttaccgac ttaggtactg tgggagaaac atcattcccc actcctactg tgagcacatg ggcattgcca gattggcatg tgacagtatc aaggtcaaca tcatctatgg cctgactgtg gccctactgt ctacaggact ggatattgtg Page 1172

120

180

240

300

360

420

480

540

600

660

069269_0225_SL.TXT

ttcatcatta tgtcgtacat catgatcctt tgcacagtgt ttcagatacc ttcctgggct 720 gccagattca aggccctcaa cacatgtgct tcccacatct gtgtcatcct tatgttctat 780 gccccagcat tcttttcatt ttttgcccat cgttttgggg gtaaaaccat ccctcaccac 840 atccacatcc tggtagccaa tctctatgtg gttgttcccc ctatgctaaa ccccatcatt 900 tatggggtga agaccaaaca gtttcaagac cgagtgatgt cgcttttctc tcccatcagc 960 acatgttgtt aa 972

<210> 1046 <211> 323 <212> PRT <213> Canis familiaris <400> 1046

Met 1 Leu Gln Glu Met 5 Ala Pro Phe Ser Tyr Asn His Thr Asn Thr Gln 10 15 Asp Met Trp Tyr Val Leu Ile Gly Ile Pro Gly Leu Glu Asp Ser His 20 25 30 Pro Trp Ile Ser Ile Pro Ile Cys Ser Met Tyr Val Leu Ala Val Ile 35 40 45 Gly Asn Ser Phe Leu Ile Phe Leu Ile Val Thr Glu Arg Ser Leu His 50 55 60 Glu Pro Met Tyr Phe Phe Leu Ser Met Leu Ala Ser Ala Asp Val Leu 65 70 75 80 Leu Ser Thr Ala Thr Ala Pro Lys Met Leu Ala Ile Phe Trp Phe Gln 85 90 95 Ser Met Asp Ile Ser Phe Gly Ser Cys Val Ser Gln Met Phe Phe Ile 100 105 110 His Phe Ile Phe Ala Thr Glu Ser Ala Ile Leu Leu Ala Met Ala Phe 115 120 125

Page 1173

Asp Arg 130 Tyr Val Ala Ile Cys 135 069269_0225_SL.TXT His Pro Leu Arg Tyr Thr 140 Thr Ile Leu Thr Ser Ser Ala Thr Gly Lys Ile Gly Ile Ala Ala Val Val Arg Ser 145 150 155 160 Phe Phe Ile Cys Leu Pro Phe Ile Phe Leu Val Tyr Arg Leu Arg Tyr 165 170 175 Cys Gly Arg Asn Ile Ile Pro His Ser Tyr Cys Glu His Met Gly Ile 180 185 190 Ala Arg Leu Ala Cys Asp Ser Ile Lys Val Asn Ile Ile Tyr Gly Leu 195 200 205 Thr Val Ala Leu Leu Ser Thr Gly Leu Asp Ile Val Phe Ile Ile Met 210 215 220 Ser Tyr Ile Met Ile Leu Cys Thr Val Phe Gln Ile Pro Ser Trp Ala 225 230 235 240 Ala Arg Phe Lys Ala Leu Asn Thr Cys Ala Ser His Ile Cys Val Ile 245 250 255 Leu Met Phe Tyr Ala Pro Ala Phe Phe Ser Phe Phe Ala His Arg Phe 260 265 270 Gly Gly Lys Thr Ile Pro His His Ile His Ile Leu Val Ala Asn Leu 275 280 285 Tyr Val Val Val Pro Pro Met Leu Asn Pro Ile Ile Tyr Gly Val Lys 290 295 300 Thr Lys Gln Phe Gln Asp Arg Val Met Ser Leu Phe Ser Pro Ile Ser 305 310 315 320 Thr Cys Cys

Page 1174

069269_0225_SL.TXT <210> 1047 <211> 819 <212> DNA <213> Canis familiaris <400> 1047

gctagtgtac tgtctgggaa ctgcctggtg ctgcatgtga tccggactga gccgagcctg 60 caccagccca tgttctactt cctggccatg ctggccctca ctgacctgtg catggggctg 120 tccacggtgc acacggtgct gggcatcctg tgggggttca ttcgagaaat cagcctggat 180 tcgtgcattg cccagtccta cttcatccat ggtctttcct tcatggagtc ctctgtcctc 240 cttactatgg cctttgatag gtatgtcgcc atttgcaatc cactgcggta ttcctccatt 300 ctgactaatt ccaggatttt caaaatcggg ctcatcatag tgggtaggag tttcttcttt 360 attacacccc ccatcatcaa tctgaaattt ttccattact gtcactccca tagcctctct 420 cactcgttct gcctacacca ggaccttctg cgtctagctt gctcagacat caggtttaat 480 agctactatg ccctgatgtt ggtcattctc acgctgttgt tggatgctgt tctcatcctt 540 tactcctatg tgctgattct tagggcagtc ctggcaattg cctctcagga ggaacagcat 600 aaattatttc agacctgcat ctcccacctg tgtgctgttc tcgtgttcta tatccctatc 660 attagcttaa caatggtgca ccgttttggc aagcatctct cacctgtgat ccatgtactt 720 atgggcaaca tctacatcct tttcccacct ttgatgaacc ccatcatcta cagtgtcaag 780 acccagcaga ttcggagcag aatgctcaga ctcttttct 819

<210> 1048 <211> 273 <212> PRT <213> Canis familiaris <400> 1048

Ala Ser Val 1 Leu Ser 5 Gly Asn Cys Leu Val Leu His Val Ile Arg Thr 10 15 Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe Leu Ala Met Leu Ala 20 25 30 Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Val His Thr Val Leu Gly 35 40 45

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Ile Leu 50 Trp Gly Phe Ile Arg Glu 55 Ile Ser Leu Asp Ser Cys Ile 60 Ala Gln Ser Tyr Phe Ile His Gly Leu Ser Phe Met Glu Ser Ser Val Leu 65 70 75 80 Leu Thr Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg 85 90 95 Tyr Ser Ser Ile Leu Thr Asn Ser Arg Ile Phe Lys Ile Gly Leu Ile 100 105 110 Ile Val Gly Arg Ser Phe Phe Phe Ile Thr Pro Pro Ile Ile Asn Leu 115 120 125 Lys Phe Phe His Tyr Cys His Ser His Ser Leu Ser His Ser Phe Cys 130 135 140 Leu His Gln Asp Leu Leu Arg Leu Ala Cys Ser Asp Ile Arg Phe Asn 145 150 155 160 Ser Tyr Tyr Ala Leu Met Leu Val Ile Leu Thr Leu Leu Leu Asp Ala 165 170 175 Val Leu Ile Leu Tyr Ser Tyr Val Leu Ile Leu Arg Ala Val Leu Ala 180 185 190 Ile Ala Ser Gln Glu Glu Gln His Lys Leu Phe Gln Thr Cys Ile Ser 195 200 205 His Leu Cys Ala Val Leu Val Phe Tyr Ile Pro Ile Ile Ser Leu Thr 210 215 220 Met Val His Arg Phe Gly Lys His Leu Ser Pro Val Ile His Val Leu 225 230 235 240 Met Gly Asn Ile Tyr Ile Leu Phe Pro Pro Leu Met Asn Pro Ile Ile 245 250 255

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Tyr Ser Val Lys Thr Gln Gln Ile Arg Ser Arg Met Leu Arg Leu Phe 260 265 270

Ser <210> 1049 <211> 864 <212> DNA <213> Canis familiaris <400> 1049 ttttctagga tggaatatgg gccccactgc tgagtctcca tctctgttgt ctaggtgtac 60 taggcagcag tgctgggcaa agccactatc attcccatcg tccacataga cttatccctg 120 aactaatcca tgtactattt tctggttatg ctggcaggaa ttgacctggg tctctgtgtt 180 ccagtattat ccacagtact gggaaagcta tggataaatt ttgtatcatt tatatgacta 240 tattttccat ccctaagttg ttcatatctt tctttcatgg agtcaatcat gcttttagcc 300 atggcatatg attgctctgt ggccattgct gaccctctga gatatccctc agtgcttatc 360 agctcccaag tagtgaggat tgttttgtgg attcagagtg catatttcac catctttcat 420 ggcctgtacc tctttggttt ctcttattgt catgacagta tcctttctca ctcctgctat 480 ctacaccagg atatgatcca actcccctgc tctggctcat ggatcaacag tttctatact 540 ttgtttttca tcttgcttgc catgggccca gacttccttt taatagtgcc ttcttatgtt 600 ctgattctca gatctgcaat ggccattgtc tcctacagga ggcaactctc agtccagcgt 660 gtgtctcaca ttcttacttc ccttttactt tatgtccttg tgctgggctc ttctatcatt 720 cacaagtttg caaagcattc cctctccctt atccacatca tcacaagcaa agtgtccatt 780 ttctttgtac ccctaatgaa cccagtcatt tttagcatca aggcctactg gatgtactga 840 accattatca aggtgttctc tttg 864 <210> 1050 <211> 35 <212> PRT <213> Canis familiaris <400> 1050

Page 1177

Phe Leu Gly Trp Asn Met Gly 069269_0225_SL.TXT Pro Thr Ala Glu Ser Pro Ser Leu Leu 1 5 10 15

Ser Arg Cys Thr Arg Gln Gln Cys Trp Ala Lys Pro Leu Ser Phe Pro 20 25 30

Ser Ser Thr 35 <210> 1051 <211> 936 <212> DNA <213> Canis familiaris <400> 1051

atgtggtcca ataacagtgc tgctcccttc ttgctaactg gcttcctggg ctcagaggca 60 attcaccact ggatctctat tcccttcttt atgatctatt tcttcatcct tttgggcaat 120 ggcacacttt tcttcctcat ttggaacgac tccagccttc atgagcccat gtactatttc 180 ctggctatgc tggcaggtac agaccttgga atgacactaa ctacaatgcc cacagtcctg 240 ggtgtcttat tgctggacca gagggaaatt tcccagggtg cctgtttcac tcagtcctac 300 ttcattcata ccctggccat tgtggaatcg ggtgtgttgc ttgccatggc ctatgaccga 360 ttcatcgcca tccgcactcc tctgaggtat aactccattc ttaccaattc tcgggtgatg 420 aaggtaggac tgggtgtact aatgaggggc tttatgtcca ttgtgccccc aatcatgcca 480 ctctactggt tcccatattg ccgttcccat gttctttccc atgccttttg cctccaccaa 540 gatgtcatga aacttgcctg tgctgatatt acatttaatc gtgtgtaccc agtcattctg 600 gttgctttga ctttcttcct agatgctctc attatactct tctcttatat tttaatcctg 660 aagacagtta tgggtattgc ctctagagaa gagagagcta aggcccttaa cacctgtgtc 720 tcacatatta gcagtgtcct ggtcttttat attactgtga ttggcctgac tttcatccac 780 aggtttggga agcatgcacc acatgtggtc cacatcacca tgagctacgt ctactttctc 840 tttcctccat tcatgaaccc cattatatat agtatgaaga ccaagcaaat tcagagaggt 900 ttcattcgcc tattttctct acacaatagg gcttga 936

<210> 1052

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069269_0225_SL.TXT <211> 311 <212> PRT <213> Canis familiaris

<400> 1052 Phe Leu 15 Met 1 Trp Ser Asn Asn Ser Ala Ala 5 Pro Phe 10 Leu Leu Thr Gly Gly Ser Glu Ala Ile His His Trp Ile Ser Ile Pro Phe Phe Met Ile 20 25 30 Tyr Phe Phe Ile Leu Leu Gly Asn Gly Thr Leu Phe Phe Leu Ile Trp 35 40 45 Asn Asp Ser Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ala Met Leu 50 55 60 Ala Gly Thr Asp Leu Gly Met Thr Leu Thr Thr Met Pro Thr Val Leu 65 70 75 80 Gly Val Leu Leu Leu Asp Gln Arg Glu Ile Ser Gln Gly Ala Cys Phe 85 90 95 Thr Gln Ser Tyr Phe Ile His Thr Leu Ala Ile Val Glu Ser Gly Val 100 105 110 Leu Leu Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Arg Thr Pro Leu 115 120 125 Arg Tyr Asn Ser Ile Leu Thr Asn Ser Arg Val Met Lys Val Gly Leu 130 135 140 Gly Val Leu Met Arg Gly Phe Met Ser Ile Val Pro Pro Ile Met Pro 145 150 155 160 Leu Tyr Trp Phe Pro Tyr Cys Arg Ser His Val Leu Ser His Ala Phe 165 170 175 Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ala Asp Ile Thr Phe 180 185 190

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Asn Arg Val Tyr Pro Val Ile Leu Val Ala Leu Thr Phe Phe Leu Asp 195 200 205 Ala Leu Ile Ile Leu Phe Ser Tyr Ile Leu Ile Leu Lys Thr Val Met 210 215 220 Gly Ile Ala Ser Arg Glu Glu Arg Ala Lys Ala Leu Asn Thr Cys Val 225 230 235 240 Ser His Ile Ser Ser Val Leu Val Phe Tyr Ile Thr Val Ile Gly Leu 245 250 255 Thr Phe Ile His Arg Phe Gly Lys His Ala Pro His Val Val His Ile 260 265 270 Thr Met Ser Tyr Val Tyr Phe Leu Phe Pro Pro Phe Met Asn Pro Ile 275 280 285 Ile Tyr Ser Met Lys Thr Lys Gln Ile Gln Arg Gly Phe Ile Arg Leu 290 295 300 Phe Ser Leu His Asn Arg Ala

305 310 <210> 1053 <211> 936 <212> DNA <213> Canis familiaris <400> 1053

atgtggctca atattagcac tgcccccttt ttgctgactg ggttcccagg tctggaggct 60 gctcatcact ggatctccat ccccttcttt gcagtctata tctctgtgct tcttggcaat 120 ggcactctcc tctacctcat caaggacgac cacagcctcc atgaacccat gtactatttc 180 cttgccatgc tggcaggtac cgatctaatg gtgacattga ctacgatgcc tactgtaatg 240 ggcgtcttat ggatgaatca ccgggagatg agccatggag cctgcttcct gcaggcttac 300 ttcattcatt ccctttccat tgtggaatcg ggtgtcttgc ttgccatggc ctatgaccga 360 ttcatcgcca tccgcactcc tctgaggtat aactccattc ttaccaattc tcgggtgatg 420

Page 1180

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aaggtaggac tgggtgtact actgaggggc tttttatccc ttgtgcctcc aattgtgcca 480 ctctactggt tcccatattg ccgttcccat gttctttccc acgccttttg cctccaccaa 540 gatgtcatga aacttgcctg tgctgatatt acatttaatc gtgtgtaccc agtcattctg 600 gttgctttga ctttcttcct agatgctctc attatcctct tctcttatat tttaatcctg 660 aagacagtta tgggtattgc ctctagagaa gagagagcta aggcccttaa cacctgtgtc 720 tcacatatta gcagtgtcct ggtcttttat attactgtga ttggcctgac tttcatccac 780 aggtttggga agcatgcacc acatgtggtc cacatcacca tgagctatgt ctactttctc 840 tttcctccat tcatgaaccc tgttatatat agtatcaaga ccaagcaaat tcagagaagc 900 atcatttacc tactttctgt gcacagaagg ccttga 936

<210> 1054 <211> 311 <212> PRT <213> Canis familiaris

<400> 1054 Ser Thr Ala Pro Phe Leu Leu Thr Gly Phe Pro Met Trp 1 Leu Asn Ile 5 10 15 Gly Leu Glu Ala Ala His His Trp Ile Ser Ile Pro Phe Phe Ala Val 20 25 30 Tyr Ile Ser Val Leu Leu Gly Asn Gly Thr Leu Leu Tyr Leu Ile Lys 35 40 45 Asp Asp His Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ala Met Leu 50 55 60 Ala Gly Thr Asp Leu Met Val Thr Leu Thr Thr Met Pro Thr Val Met 65 70 75 80 Gly Val Leu Trp Met Asn His Arg Glu Met Ser His Gly Ala Cys Phe 85 90 95 Leu Gln Ala Tyr Phe Ile His Ser Leu Ser Ile Val Glu Ser Gly Val 100 105 110

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Leu Leu Ala 115 Met Ala Tyr Asp Arg Phe Ile Ala Ile Arg Thr Pro Leu 120 125 Arg Tyr Asn Ser Ile Leu Thr Asn Ser Arg Val Met Lys Val Gly Leu 130 135 140 Gly Val Leu Leu Arg Gly Phe Leu Ser Leu Val Pro Pro Ile Val Pro 145 150 155 160 Leu Tyr Trp Phe Pro Tyr Cys Arg Ser His Val Leu Ser His Ala Phe 165 170 175 Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ala Asp Ile Thr Phe 180 185 190 Asn Arg Val Tyr Pro Val Ile Leu Val Ala Leu Thr Phe Phe Leu Asp 195 200 205 Ala Leu Ile Ile Leu Phe Ser Tyr Ile Leu Ile Leu Lys Thr Val Met 210 215 220 Gly Ile Ala Ser Arg Glu Glu Arg Ala Lys Ala Leu Asn Thr Cys Val 225 230 235 240 Ser His Ile Ser Ser Val Leu Val Phe Tyr Ile Thr Val Ile Gly Leu 245 250 255 Thr Phe Ile His Arg Phe Gly Lys His Ala Pro His Val Val His Ile 260 265 270 Thr Met Ser Tyr Val Tyr Phe Leu Phe Pro Pro Phe Met Asn Pro Val 275 280 285 Ile Tyr Ser Ile Lys Thr Lys Gln Ile Gln Arg Ser Ile Ile Tyr Leu 290 295 300 Leu Ser Val His Arg Arg Pro

305 310

Page 1182

069269_0225_SL.TXT <210> 1055 <211> 1008 <212> DNA <213> Canis familiaris <400> 1055

atatggccca aaattagcac tgcccccttt ttgctgactg ggttcccagg tctggaggct 60 gctcatcact ggatctcccc acttttcccc ttctttgcag tctacatctc tgtgcttctt 120 ggcaatggca ctctcctcta cctcatcaag gacgaccaca gcctccatga acccatgtac 180 tatttccttg ccatgctggc aggtaccgat ctgatggtga cattgactat gatgcctact 240 gtaatgggcg tcttatggat gaatcaccgg gagatgagcc atggagcctg cttcctgcag 300 gcttacttca ttcattccct ttccattgtg gaatcagatg tcttgcttgc catggcctat 360 gatcatttta ttgccatcca caatcctttg cgatacactt ccattctcac caatattcaa 420 gtggtaatgt tagggatggg agcttttatg agggatttta tattcatcat ccctctaatc 480 ttgtatcatt ttattttttc atttccatat tgccattcta atattctctc ccatgctttc 540 tgtcttcatc aagaagtcat gaaactggcc tgtgctgaca taactttcaa tagaccttac 600 cctctatttt tttctctttc tttctttctt tctttctttc tttctttctt tctttctttc 660 tttctttctt tctttctttc ttctttcttt ctctttcttt tttttttttt cctagattct 720 ctgatcatcc ttttctccta tatcctaatt cttaagactg tcatgggcat agcctttggt 780 gaagagagaa ccgagtccct caatacttgt atctcccacg ctggctgtgt cctcatcttt 840 tatgtcactg tgattttgtc attaatccat cagtttggga agaatgtgcc accagtggtc 900 cacattataa tgagctatat ctacttcctc tttcctcctt taacgaatcc taccatctat 960 agcatcaaga caaagcaaat tcaatatggc attctctgcc ttttatcc 1008

<210> 1056 <211> 336 <212> PRT <213> Canis familiaris <400> 1056

Ile Trp Pro Lys Ile Ser Thr Ala Pro Phe Leu Leu Thr Gly Phe Pro 1 5 10 15

Page 1183

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Gly Leu Glu Ala 20 Ala His His Trp Ile Ser Pro Leu Phe Pro Phe Phe 25 30 Ala Val Tyr Ile Ser Val Leu Leu Gly Asn Gly Thr Leu Leu Tyr Leu 35 40 45 Ile Lys Asp Asp His Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ala 50 55 60 Met Leu Ala Gly Thr Asp Leu Met Val Thr Leu Thr Met Met Pro Thr 65 70 75 80 Val Met Gly Val Leu Trp Met Asn His Arg Glu Met Ser His Gly Ala 85 90 95 Cys Phe Leu Gln Ala Tyr Phe Ile His Ser Leu Ser Ile Val Glu Ser 100 105 110 Asp Val Leu Leu Ala Met Ala Tyr Asp His Phe Ile Ala Ile His Asn 115 120 125 Pro Leu Arg Tyr Thr Ser Ile Leu Thr Asn Ile Gln Val Val Met Leu 130 135 140 Gly Met Gly Ala Phe Met Arg Asp Phe Ile Phe Ile Ile Pro Leu Ile 145 150 155 160 Leu Tyr His Phe Ile Phe Ser Phe Pro Tyr Cys His Ser Asn Ile Leu 165 170 175 Ser His Ala Phe Cys Leu His Gln Glu Val Met Lys Leu Ala Cys Ala 180 185 190 Asp Ile Thr Phe Asn Arg Pro Tyr Pro Leu Phe Phe Ser Leu Ser Phe 195 200 205 Phe Leu Ser Phe Phe Leu Ser Phe Phe Leu Ser Phe Phe Leu Ser Phe 210 215 220

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Phe 225 Leu Ser Ser Phe Phe Leu 230 Phe Leu Phe Phe Phe Phe Leu Asp Ser 235 240 Leu Ile Ile Leu Phe Ser Tyr Ile Leu Ile Leu Lys Thr Val Met Gly 245 250 255 Ile Ala Phe Gly Glu Glu Arg Thr Glu Ser Leu Asn Thr Cys Ile Ser 260 265 270 His Ala Gly Cys Val Leu Ile Phe Tyr Val Thr Val Ile Leu Ser Leu 275 280 285 Ile His Gln Phe Gly Lys Asn Val Pro Pro Val Val His Ile Ile Met 290 295 300 Ser Tyr Ile Tyr Phe Leu Phe Pro Pro Leu Thr Asn Pro Thr Ile Tyr 305 310 315 320 Ser Ile Lys Thr Lys Gln Ile Gln Tyr Gly Ile Leu Cys Leu Leu Ser 325 330 335

<210> 1057 <211> 954 <212> DNA <213> Canis familiaris <400> 1057

atgttcatgt ctaataatgc ctgtttggtg cctagttctt tctggcttac tggtattcca 60 gggctgcaat ccctgcacat ctggctctcc atccccttca gctctatgta cctgatggct 120 atagtgggga atgtgactat cctggcagtg ataaaggtgg aacgcagcct gcaccaaccc 180 atgtacttct tcctgtgcat gttggctgtc attgacttgg tcctttcaac gtctaccatg 240 cccaaactac tagccatctt ctggtttggt gcccacaaca ttgacctgga tgcctgcttg 300 gctcagatgt tcttcatcca ctgctttgcc actgttgagt caggaatctt ccttgccatg 360 gcttttgatc gctatgtggc catatgtgac ccattacgcc acaccttggt gctcactcat 420 gcagcagtgg gtcgtttggg cttggctgcc ctcttccgtg gagtactcta cattgggcct 480 ctgcctctga tgattcgcct gaggctgcct cattaccaga cccaaatcat tgcccattcc 540

Page 1185

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tattgtgagc acatggccat agttacctta gcatgtggtg acacaacagt caacaacttg 600 tatggaatgg gaattggctt cctggtattg atcctagatt cattagctat cactgcctca 660 tatgtgatga ttttcagggc tgtaatgggg ttggccaccc cagaggccag gcttaaaact 720 ctagggacat gtagttctca catttgtgcc attcttgtct tctatatccc cattgctgtt 780 tcttctctca ctcaccgctt tggccatcat gtgcctcctc atatccatat ccttttggcc 840 aacttttacc tcctcattcc acccattctc aacccagttg tctatgctgt ccgtaccaaa 900 cagattcgag agagacttct ctacattctt aaggcagggt ctcaacccaa gtga 954

<210> 1058 <211> 317 <212> PRT <213> Canis familiaris

<400> 1058 Phe Trp Leu 15 Met 1 Phe Met Ser Asn Asn 5 Ala Cys Leu Val 10 Pro Ser Ser Thr Gly Ile Pro Gly Leu Gln Ser Leu His Ile Trp Leu Ser Ile Pro 20 25 30 Phe Ser Ser Met Tyr Leu Met Ala Ile Val Gly Asn Val Thr Ile Leu 35 40 45 Ala Val Ile Lys Val Glu Arg Ser Leu His Gln Pro Met Tyr Phe Phe 50 55 60 Leu Cys Met Leu Ala Val Ile Asp Leu Val Leu Ser Thr Ser Thr Met 65 70 75 80 Pro Lys Leu Leu Ala Ile Phe Trp Phe Gly Ala His Asn Ile Asp Leu 85 90 95 Asp Ala Cys Leu Ala Gln Met Phe Phe Ile His Cys Phe Ala Thr Val 100 105 110 Glu Ser Gly Ile Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125

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Cys Asp Pro Leu Arg His Thr Leu 135 Val Leu Thr His 140 Ala Ala Val Gly 130 Arg Leu Gly Leu Ala Ala Leu Phe Arg Gly Val Leu Tyr Ile Gly Pro 145 150 155 160 Leu Pro Leu Met Ile Arg Leu Arg Leu Pro His Tyr Gln Thr Gln Ile 165 170 175 Ile Ala His Ser Tyr Cys Glu His Met Ala Ile Val Thr Leu Ala Cys 180 185 190 Gly Asp Thr Thr Val Asn Asn Leu Tyr Gly Met Gly Ile Gly Phe Leu 195 200 205 Val Leu Ile Leu Asp Ser Leu Ala Ile Thr Ala Ser Tyr Val Met Ile 210 215 220 Phe Arg Ala Val Met Gly Leu Ala Thr Pro Glu Ala Arg Leu Lys Thr 225 230 235 240 Leu Gly Thr Cys Ser Ser His Ile Cys Ala Ile Leu Val Phe Tyr Ile 245 250 255 Pro Ile Ala Val Ser Ser Leu Thr His Arg Phe Gly His His Val Pro 260 265 270 Pro His Ile His Ile Leu Leu Ala Asn Phe Tyr Leu Leu Ile Pro Pro 275 280 285 Ile Leu Asn Pro Val Val Tyr Ala Val Arg Thr Lys Gln Ile Arg Glu 290 295 300 Arg Leu Leu Tyr Ile Leu Lys Ala Gly Ser Gln Pro Lys 305 310 315

<210> 1059 <211> 933

Page 1187

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 1059

atgtggccca acatcagtgc tgcccctttt ctactgactg gcttcccagg tctggagata 60 tttcatcctt ggatctcgat ctccttcttt gtcatttatg tctccatact cctcagcaat 120 ggtaccctcc tcttccttat cagagaagac cacactctcc atgagccaat gtactacttt 180 ttggcgatac tggcagccac agaccttgga gtgactttga caacgatgcc tactgtgctt 240 ggtgttctat ggcttgatca tagggccatc agccatgaag cctgctactt tcaggcctat 300 ctaatccatt cactctctat tgtagagtct ggagtcttgc tcattatggc ctatgatcgt 360 tttattgcca tccgcaaccc cctgagatac acttccattc tcactaatgc taaggtggtg 420 aagataggtc tggggattct aatgagggga tttatcctca ttgttcctat aatcatcact 480 ctctctggat tcccctactg caaatcccat gtcctctccc atgctttctg cttacaccag 540 gatgtgatca aactggcctg tgccgacatc acctttaata gaatctatcc tatagtcctg 600 gtctcattaa ctggtttctt ggactctata cttattctta tctcttatat tttaatcctt 660 aatactatca tgggaattgc ctcaggtaag gagcgggcta aggctctaaa cacttgtgtc 720 tcccacatta gctgtgttct ggttttttat gtcactgtta ctgggctgac tctcattcat 780 cgatttggga aatatgtgcc tcatatagtt catattatca tgagctatat atatttccta 840 ttccctccat ttatgaatcc aataatctat agtattaaga caaagcagat aaggaatggt 900 atcaatcacc ttctctcttt ccatagaatt tga 933

<210> 1060 <211> 310 <212> PRT <213> Canis familiaris <400> 1060

Met Trp Pro Asn Ile Ser Ala Ala Pro Phe Leu Leu Thr Gly Phe Pro

1 5 10 15

Gly Leu Glu Ile Phe His Pro Trp Ile Ser Ile Ser Phe Phe Val Ile

20 25 30

Tyr Val Ser Ile Leu Leu Ser Asn Gly Thr Leu Leu Phe Leu Ile Arg Page 1188

069269_0225_SL.TXT 40 45

Glu Asp His Thr Leu His Glu Pro Met Tyr Tyr Phe Leu Ala Ile Leu 50 55 60 Ala Ala Thr Asp Leu Gly Val Thr Leu Thr Thr Met Pro Thr Val Leu 65 70 75 80 Gly Val Leu Trp Leu Asp His Arg Ala Ile Ser His Glu Ala Cys Tyr 85 90 95 Phe Gln Ala Tyr Leu Ile His Ser Leu Ser Ile Val Glu Ser Gly Val 100 105 110 Leu Leu Ile Met Ala Tyr Asp Arg Phe Ile Ala Ile Arg Asn Pro Leu 115 120 125 Arg Tyr Thr Ser Ile Leu Thr Asn Ala Lys Val Val Lys Ile Gly Leu 130 135 140 Gly Ile Leu Met Arg Gly Phe Ile Leu Ile Val Pro Ile Ile Ile Thr 145 150 155 160 Leu Ser Gly Phe Pro Tyr Cys Lys Ser His Val Leu Ser His Ala Phe 165 170 175 Cys Leu His Gln Asp Val Ile Lys Leu Ala Cys Ala Asp Ile Thr Phe 180 185 190 Asn Arg Ile Tyr Pro Ile Val Leu Val Ser Leu Thr Gly Phe Leu Asp 195 200 205 Ser Ile Leu Ile Leu Ile Ser Tyr Ile Leu Ile Leu Asn Thr Ile Met 210 215 220 Gly Ile Ala Ser Gly Lys Glu Arg Ala Lys Ala Leu Asn Thr Cys Val 225 230 235 240 Ser His Ile Ser Cys Val Leu Val Phe Tyr Val Thr Val Thr Gly Leu

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245 250 255

Thr Leu Ile His Arg Phe Gly Lys Tyr 265 Val Pro His Ile Val 270 His Ile 260 Ile Met Ser Tyr Ile Tyr Phe Leu Phe Pro Pro Phe Met Asn Pro Ile 275 280 285 Ile Tyr Ser Ile Lys Thr Lys Gln Ile Arg Asn Gly Ile Asn His Leu 290 295 300 Leu Ser Phe His Arg Ile 305 310

<210> 1061 <211> 939 <212> DNA <213> Canis familiaris <400> 1061

atgtggccca acagcagttc cagttccttc cttttgactg gttttccagg cttggaggca 60 gttcaccact ggatttccac acccttcttt ttcatctacg tctctatcct tttaggcaac 120 agcactctcc ttcttctcat taaggaagat cacaatcttc atgagcctat gtactacttc 180 ctggccatgc tggcagccac agacctaggg ctgactttga ccacaatgcc tacagtgttg 240 ggagtcctct ggttggatca cagggagatt ggaaaagtag cctgtttttc tcaagcctac 300 tttatacact cacttgcctt tgtagaatct ggtgttttgc ttgctatggc ctatgatcgt 360 tttattgcca tttgcaaccc ccttagatat agctctatac tcactaataa tcaagtgctg 420 aaaattgggc taggagttct gatgaggggg tttatatctg ttgttcctcc aatcttaccc 480 ctttactttt ttccctattg ccattctcac atcctctcac atgcattctg ccttcaccag 540 gacgtcatca aactggcctg tgctgatacc accttcaatc gcctatatcc agttgtgctt 600 gtagtcttga tatttgtgct ggattctctg attatcctca tctcctatgt gttgatactc 660 aagagagtcc tgagtattgc ctccaaagaa gagagggcca agaccctcaa cacctgtgtc 720 tcccatatct gctgtgtcct ggttttctat gtcacagtga ttggactgtc tctgattcat 780 cggtttggaa agcaggttcc acatattgtt caccttacta tgagctacat atattttatt 840

Page 1190

069269_0225_SL.TXT ttccctccat taatgaatcc tataatctat agtgtcaaga ccaagcagat ccagattggc atttttcgcc ttttcactac ccatagaatc aaagtatga

900

939 <210> 1062 <211> 312 <212> PRT <213> Canis familiaris

<400> 1062 Ser Ser Ser Ser Phe Leu Leu Thr Gly Phe Pro Met Trp 1 Pro Asn Ser 5 10 15 Gly Leu Glu Ala Val His His Trp Ile Ser Thr Pro Phe Phe Phe Ile 20 25 30 Tyr Val Ser Ile Leu Leu Gly Asn Ser Thr Leu Leu Leu Leu Ile Lys 35 40 45 Glu Asp His Asn Leu His Glu Pro Met Tyr Tyr Phe Leu Ala Met Leu 50 55 60 Ala Ala Thr Asp Leu Gly Leu Thr Leu Thr Thr Met Pro Thr Val Leu 65 70 75 80 Gly Val Leu Trp Leu Asp His Arg Glu Ile Gly Lys Val Ala Cys Phe 85 90 95 Ser Gln Ala Tyr Phe Ile His Ser Leu Ala Phe Val Glu Ser Gly Val 100 105 110 Leu Leu Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Cys Asn Pro Leu 115 120 125 Arg Tyr Ser Ser Ile Leu Thr Asn Asn Gln Val Leu Lys Ile Gly Leu 130 135 140 Gly Val Leu Met Arg Gly Phe Ile Ser Val Val Pro Pro Ile Leu Pro 145 150 155 160

Page 1191

Leu Tyr Phe Phe Pro 165 Tyr Cys 069269_0225_SL.TXT His Ser His Ile Leu Ser 170 His Ala 175 Phe Cys Leu His Gln Asp Val Ile Lys Leu Ala Cys Ala Asp Thr Thr Phe 180 185 190 Asn Arg Leu Tyr Pro Val Val Leu Val Val Leu Ile Phe Val Leu Asp 195 200 205 Ser Leu Ile Ile Leu Ile Ser Tyr Val Leu Ile Leu Lys Arg Val Leu 210 215 220 Ser Ile Ala Ser Lys Glu Glu Arg Ala Lys Thr Leu Asn Thr Cys Val 225 230 235 240 Ser His Ile Cys Cys Val Leu Val Phe Tyr Val Thr Val Ile Gly Leu 245 250 255 Ser Leu Ile His Arg Phe Gly Lys Gln Val Pro His Ile Val His Leu 260 265 270 Thr Met Ser Tyr Ile Tyr Phe Ile Phe Pro Pro Leu Met Asn Pro Ile 275 280 285 Ile Tyr Ser Val Lys Thr Lys Gln Ile Gln Ile Gly Ile Phe Arg Leu 290 295 300 Phe Thr Thr His Arg Ile Lys Val 305 310

<210> 1063 <211> 939 <212> DNA <213> Canis familiaris <400> 1063 atgtggctca acactactgt ttccccattt ctgcttactg gcttcccagg catggagaag gcacaccact ggatttccat cccattattg gtggtttatg tctccattat tcttggtaat ggcacccttc tctttcttat caaagatgat catagccttc atgagcccat gtactatttt

120

180

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ttagctatgt tggcagccac agaccttgga gtgactttga ccacaatgcc cacagttctg 240 ggtgtcctat ggttaaatca cagagagatt ggccatcagg tctgtttctc tcaggcctat 300 tttatccata ctctttctat tgtggaatct ggtgttttgc ttgccatggc ctatgaccgt 360 ttcattgcca tccgcaaccc cttgagatat acttccatcc ttaccaatac caaggtaatg 420 aagattggga taggggtatt gacaagggct ggtctgtcaa ttatgccaat aattattcgc 480 cttcactggt ttccctactg tcattcccat gtactttctc atgctttttg tctacaccaa 540 gatgtcatta agttagcctg tgctgacatc accttcaatc gactctatcc agttgtggtt 600 gtatttgcaa tggtcttgtt ggactttctc atcatctttt tctcctacat tttgatcctc 660 aagactgtca tgggcattgc ttctggagaa gaaagagcca aggccctcaa cacctgtgtc 720 tctcacatct gttgtatctt ggtcttctat gtcactgtag ttggtctgac atttattcat 780 agatttggaa aacatgctcc tcatgtggtc cacatcacaa tgagctatat ctacttcctc 840 ttcccccctt ttatgaaccc tgttatctat agcattaaaa ccaagcagat ccagagtggt 900 atagttcgtt tattctctct gcctaattct agagcataa 939

<210> 1064 <211> 312 <212> PRT <213> Canis familiaris <400> 1064

Met Trp Leu Asn Thr Thr Val Ser Pro Phe Leu Leu Thr Gly Phe Pro 1 5 10 15 Gly Met Glu Lys Ala His His Trp Ile Ser Ile Pro Leu Leu Val Val 20 25 30 Tyr Val Ser Ile Ile Leu Gly Asn Gly Thr Leu Leu Phe Leu Ile Lys 35 40 45 Asp Asp His Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ala Met Leu 50 55 60 Ala Ala Thr Asp Leu Gly Val Thr Leu Thr Thr Met Pro Thr Val Leu 65 70 75 80

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Gly Val Leu Trp Leu 85 Asn His Arg Glu Ile Gly His Gln Val Cys Phe 90 95 Ser Gln Ala Tyr Phe Ile His Thr Leu Ser Ile Val Glu Ser Gly Val 100 105 110 Leu Leu Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Arg Asn Pro Leu 115 120 125 Arg Tyr Thr Ser Ile Leu Thr Asn Thr Lys Val Met Lys Ile Gly Ile 130 135 140 Gly Val Leu Thr Arg Ala Gly Leu Ser Ile Met Pro Ile Ile Ile Arg 145 150 155 160 Leu His Trp Phe Pro Tyr Cys His Ser His Val Leu Ser His Ala Phe 165 170 175 Cys Leu His Gln Asp Val Ile Lys Leu Ala Cys Ala Asp Ile Thr Phe 180 185 190 Asn Arg Leu Tyr Pro Val Val Val Val Phe Ala Met Val Leu Leu Asp 195 200 205 Phe Leu Ile Ile Phe Phe Ser Tyr Ile Leu Ile Leu Lys Thr Val Met 210 215 220 Gly Ile Ala Ser Gly Glu Glu Arg Ala Lys Ala Leu Asn Thr Cys Val 225 230 235 240 Ser His Ile Cys Cys Ile Leu Val Phe Tyr Val Thr Val Val Gly Leu 245 250 255 Thr Phe Ile His Arg Phe Gly Lys His Ala Pro His Val Val His Ile 260 265 270 Thr Met Ser Tyr Ile Tyr Phe Leu Phe Pro Pro Phe Met Asn Pro Val 275 280 285

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Ile Tyr Ser Ile Lys Thr Lys Gln Ile Gln Ser Gly Ile Val Arg Leu 290 295 300

Phe Ser Leu Pro Asn Ser Arg Ala

305 310 <210> 1065 <211> 954 <212> DNA <213> Canis familiaris <400> 1065

atgaaaatgc ctattatgga actcaatacc agtgctacac cctttctgct gactggcttc 60 gtgggcctgg aaaaagcaca ccactggatc tccatcccat tatctgtcgt ctatatctct 120 atacttcttg gcaatggcat tctcctattt ctcatcaggg ttgaccataa cctccatgaa 180 cccatgtact atttcttagc cctgctggca accacagacc tagggatgac cctagttaca 240 atgcctactg tgctgtgtgt gatgtggata aatcacaggg aagtcagcca tggcatctgc 300 tttctccaag cctacttcat ccacagcctc tctatgatag agtctggaat tttgcttgcc 360 atggcctatg atcggtttat tgccatccgc aacccactga gatatacttc cattatcacc 420 aacatccaag tgttaaagat tggagtggga gttttcatga ggggatttgt tctcatcttg 480 cctccaatat tgcctctcta ctggttttcc tattgcagat cccatgtcct ctctcatgca 540 ttctgtcttc accaggatgt tatcaaatta gcctgtgctg acatcacctt caatcgcctg 600 tatcctgttg tggtggtatt ttctatggtc ctaatggact gcttgataat attttgctcc 660 tatattttga tactccagac tgtgatgagc attgcctctg aagaagagag gtccaaggcc 720 ctcaacactt gtgtctccca catctgctgc atcttggtct tctatgtcac tgtttttggt 780 ttgacattca tccaccgatt tgggaagaat gttccccatc tagtacacat cataatgagc 840 tacatctact tccttttccc ccctttcatg aaccctatta tctatagtat taaaactaag 900 cagattcgtg gtagtatact ccaattattt tctctgtccc caccaagaac atga 954

<210> 1066 <211> 317 <212> PRT <213> Canis familiaris

Page 1195

069269_0225_SL.TXT <400> 1066

Met 1 Lys Met Pro Ile Met Glu Leu Asn Thr Ser Ala Thr Pro Phe Leu 5 10 15 Leu Thr Gly Phe Val Gly Leu Glu Lys Ala His His Trp Ile Ser Ile 20 25 30 Pro Leu Ser Val Val Tyr Ile Ser Ile Leu Leu Gly Asn Gly Ile Leu 35 40 45 Leu Phe Leu Ile Arg Val Asp His Asn Leu His Glu Pro Met Tyr Tyr 50 55 60 Phe Leu Ala Leu Leu Ala Thr Thr Asp Leu Gly Met Thr Leu Val Thr 65 70 75 80 Met Pro Thr Val Leu Cys Val Met Trp Ile Asn His Arg Glu Val Ser 85 90 95 His Gly Ile Cys Phe Leu Gln Ala Tyr Phe Ile His Ser Leu Ser Met 100 105 110 Ile Glu Ser Gly Ile Leu Leu Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Arg Asn Pro Leu Arg Tyr Thr Ser Ile Ile Thr Asn Ile Gln Val 130 135 140 Leu Lys Ile Gly Val Gly Val Phe Met Arg Gly Phe Val Leu Ile Leu 145 150 155 160 Pro Pro Ile Leu Pro Leu Tyr Trp Phe Ser Tyr Cys Arg Ser His Val 165 170 175 Leu Ser His Ala Phe Cys Leu His Gln Asp Val Ile Lys Leu Ala Cys 180 185 190 Ala Asp Ile Thr Phe Asn Arg Leu Tyr Pro Val Val Val Val Phe Ser 195 200 205

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Met Val Leu Met Asp Cys Leu 215 Ile Ile Phe Cys Ser Tyr Ile Leu Ile 220 210 Leu Gln Thr Val Met Ser Ile Ala Ser Glu Glu Glu Arg Ser Lys Ala 225 230 235 240 Leu Asn Thr Cys Val Ser His Ile Cys Cys Ile Leu Val Phe Tyr Val 245 250 255 Thr Val Phe Gly Leu Thr Phe Ile His Arg Phe Gly Lys Asn Val Pro 260 265 270 His Leu Val His Ile Ile Met Ser Tyr Ile Tyr Phe Leu Phe Pro Pro 275 280 285 Phe Met Asn Pro Ile Ile Tyr Ser Ile Lys Thr Lys Gln Ile Arg Gly 290 295 300 Ser Ile Leu Gln Leu Phe Ser Leu Ser Pro Pro Arg Thr 305 310 315

<210> 1067 <211> 813 <212> DNA <213> Canis familiaris <400> 1067

gttactaact ccactcaagt ccccttttgc ttcatcctta atggcatccc tggctttgag 60 gttttccata actggatttc catccccttt tgttgtctct acactgtctc catcatgggc 120 aataccacca tcctggcggt catcaggaca gagccctccc tacataagcc catgtacttg 180 ttcctctcta tgttggctgt aacagctctg gggctcaccc tcaccacttt gcctacagtc 240 atgggagtcc tctggtttgg ggcctcagaa attagctttg aggcttgttt tgcccagttc 300 ttcttcctcc atggattctc ctttatagaa tcttctgtgt tgctggccat gtcctttgat 360 cgctatgtgg ccttctgccg tcccctgcat tatgtctcca tcctcaccaa ccaagtaatc 420 agaagaatag gggtggccat catttgccac tgtgttctgg ctgttcctcc cccattgctc 480

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069269_0225_SL.TXT ctgctgaaac gattgccctt ttgtggctcc caccagcttt cccactccta ctgcctccat caagacatga tttgccgggt gtgtgctgac accactgtca ataactggta tggatttgtt ctagctctgg tcattattac actggacccc ctgctcattg tgctttccta tgtactcatc ctgagaagtg tcttgagaat cagctcccag gttgaaaggc ttcgggcact caataactgt ctatcccata ttctggctgt tttggtcctc tatgtgccca tggtgggatt gtccatgact caccgctttg ccaagcatgc ccctccaatt gtc

540

600

660

720

780

813 <210> 1068 <211> 271 <212> PRT <213> Canis familiaris <400> 1068

Val 1 Thr Asn Ser Thr 5 Gln Val Pro Phe Cys Phe Ile Leu Asn Gly Ile 10 15 Pro Gly Phe Glu Val Phe His Asn Trp Ile Ser Ile Pro Phe Cys Cys 20 25 30 Leu Tyr Thr Val Ser Ile Met Gly Asn Thr Thr Ile Leu Ala Val Ile 35 40 45 Arg Thr Glu Pro Ser Leu His Lys Pro Met Tyr Leu Phe Leu Ser Met 50 55 60 Leu Ala Val Thr Ala Leu Gly Leu Thr Leu Thr Thr Leu Pro Thr Val 65 70 75 80 Met Gly Val Leu Trp Phe Gly Ala Ser Glu Ile Ser Phe Glu Ala Cys 85 90 95 Phe Ala Gln Phe Phe Phe Leu His Gly Phe Ser Phe Ile Glu Ser Ser 100 105 110 Val Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Phe Cys Arg Pro 115 120 125 Leu His Tyr Val Ser Ile Leu Thr Asn Gln Val Ile Arg Arg Ile Gly

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130 135 069269_0225_SL.TXT 140 Val Ala Ile Ile Cys His Cys Val Leu Ala Val Pro Pro Pro Leu Leu 145 150 155 160 Leu Leu Lys Arg Leu Pro Phe Cys Gly Ser His Gln Leu Ser His Ser 165 170 175 Tyr Cys Leu His Gln Asp Met Ile Cys Arg Val Cys Ala Asp Thr Thr 180 185 190 Val Asn Asn Trp Tyr Gly Phe Val Leu Ala Leu Val Ile Ile Thr Leu 195 200 205 Asp Pro Leu Leu Ile Val Leu Ser Tyr Val Leu Ile Leu Arg Ser Val 210 215 220 Leu Arg Ile Ser Ser Gln Val Glu Arg Leu Arg Ala Leu Asn Asn Cys 225 230 235 240 Leu Ser His Ile Leu Ala Val Leu Val Leu Tyr Val Pro Met Val Gly 245 250 255 Leu Ser Met Thr His Arg Phe Ala Lys His Ala Pro Pro Ile Val 260 265 270

<210> 1069 <211> 960 <212> DNA <213> Canis familiaris <400> 1069

atgctcttgt ccaatatcac tcagtttagc cccatgttgt acctcactgg ctttcctgga 60 ttagaaacca tcgaacactg gatcttcatc ccctttttcc ttatgtacct tgtggccatc 120 tcaggcaatt gtttcattct gataattatc aagaccaacc atcgtctaca cacacccatg 180 tactatctac tctcctttct ggccttcact gacctgggac tgtcagtgtc aactttgccc 240 actactatgg gaatcttttg gttcaaatct cgtggtatct acttttcagc ttgccaaatc 300 cagatgttct gtatccactc attttccttc atggagtctt cagtgctcct tataatgtcc 360

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tttgaccgct gtttggccat ctgccacccc cttaggtact cggtcattat cactagccag 420 cgagtggtaa gggcaggcct ggctgtcatc ttccggggac ctgtggccct agttcctctt 480 gtcgtcctcc tgaagacttt tccctactgt gggcctcgag tcctctccca ttccttctgc 540 ctacaccagg aagtgataca cctggcctgc acagacacct ccttcaacaa cctgtatgga 600 ctggcggtgg tggtattcac tatgatgctg gacctggtgc tcatcgcact gtcctatggg 660 gtcatcctgc gcactgtggc aagactggcc tcccaagagg agcaactccg agccttccaa 720 acatgtacct cacacctctg tgctgtgctg atattctttg tacccatggt ggggctgtct 780 ctggtacacc gctttgggaa gcatgtacca cttgctgtcc accttcttat ggccaatgtc 840 tatctctttg taccacccat gcttaatcca atcatatata gtattaagac caaggagatc 900 cgtcatgtta tcagcaagct cctgggtctt aggaaggtca gtgctgagtc ctggggctaa 960

<210> 1070 <211> 319 <212> PRT <213> Canis familiaris <400> 1070

Met 1 Leu Leu Ser Asn Ile 5 Thr Gln Phe Ser Pro Met 10 Leu Tyr Leu 15 Thr Gly Phe Pro Gly Leu Glu Thr Ile Glu His Trp Ile Phe Ile Pro Phe 20 25 30 Phe Leu Met Tyr Leu Val Ala Ile Ser Gly Asn Cys Phe Ile Leu Ile 35 40 45 Ile Ile Lys Thr Asn His Arg Leu His Thr Pro Met Tyr Tyr Leu Leu 50 55 60 Ser Phe Leu Ala Phe Thr Asp Leu Gly Leu Ser Val Ser Thr Leu Pro 65 70 75 80 Thr Thr Met Gly Ile Phe Trp Phe Lys Ser Arg Gly Ile Tyr Phe Ser 85 90 95

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Ala Cys Gln Ile 100 Gln Met Phe Cys Ile His Ser Phe Ser Phe Met Glu 105 110 Ser Ser Val Leu Leu Ile Met Ser Phe Asp Arg Cys Leu Ala Ile Cys 115 120 125 His Pro Leu Arg Tyr Ser Val Ile Ile Thr Ser Gln Arg Val Val Arg 130 135 140 Ala Gly Leu Ala Val Ile Phe Arg Gly Pro Val Ala Leu Val Pro Leu 145 150 155 160 Val Val Leu Leu Lys Thr Phe Pro Tyr Cys Gly Pro Arg Val Leu Ser 165 170 175 His Ser Phe Cys Leu His Gln Glu Val Ile His Leu Ala Cys Thr Asp 180 185 190 Thr Ser Phe Asn Asn Leu Tyr Gly Leu Ala Val Val Val Phe Thr Met 195 200 205 Met Leu Asp Leu Val Leu Ile Ala Leu Ser Tyr Gly Val Ile Leu Arg 210 215 220 Thr Val Ala Arg Leu Ala Ser Gln Glu Glu Gln Leu Arg Ala Phe Gln 225 230 235 240 Thr Cys Thr Ser His Leu Cys Ala Val Leu Ile Phe Phe Val Pro Met 245 250 255 Val Gly Leu Ser Leu Val His Arg Phe Gly Lys His Val Pro Leu Ala 260 265 270 Val His Leu Leu Met Ala Asn Val Tyr Leu Phe Val Pro Pro Met Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Ile Lys Thr Lys Glu Ile Arg His Val Ile 290 295 300

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Ser Lys Leu Leu Gly Leu Arg Lys Val Ser Ala Glu Ser Trp Gly 305 310 315 <210> 1071 <211> 954 <212> DNA <213> Canis familiaris <400> 1071

atgaggatat ccaccctacc aagggccaac atgagcttct ctacattcct gctaacaggt 60 ttcccaggcc tggaatgggc tcaccactgg atctcactac ccatttttgt aggatacttg 120 gtgaccctca taggtaatgc taccatcttg catctggtac gaactgaacc ttctctccag 180 cagcccatgt actacttctt ggccatcctg gctgtgacag acttgggcct gtgcatgtcc 240 acgctgccct cagtgttagg tgtactgtgg tttgacgccc ggagggtggg cctggtgccg 300 tgtgttctgc agcagcattt cctgcactcc ttctccttca tggagtcagc tgtgctcttt 360 gctatggccc tggaccgcct ggtggccatc cggttcccat tgcattatgc atctgtgctc 420 acaggtcctc gcgtggcact ggccggggct gtgctgggta tgcgcagtgc cgccatcaca 480 gctgcgccct cactgcatct gttgaagttt gactattgtc gcccagggtc tctgtctcat 540 gcctactgcc ttcaccagga catgatccgc ctggcctgct ccgacacacg cttcaacaga 600 ctctatgggt tgtgcatcat catgctggcc atgggttcag atgtcctttt catcctgctc 660 tcctacgctg tcatcctccg cactgtgctg gccatcgctt ctgccgggga gaggctcaaa 720 gccctcaata cttgtgtctc gcacatcctg gctgtgcttt gcttctatgt gcctgtgcta 780 ggcctttcca tcgtgcacag atttggacac cacacttcgc ccttagtgca catcctcatg 840 ggcaccgtct ccgtgctctt cccacccctg atgaaccccg ttatctatag catcaagacc 900 cagcagatcc gcagggccat cctcaaggtg gtttcactgg ggaagataca gtga 954

<210> 1072 <211> 317 <212> PRT <213> Canis familiaris <400> 1072

Met Arg Ile Ser Thr Leu Pro Arg Ala Asn Met Ser Phe Ser Thr Phe 1 5 10 15

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Leu Leu Thr Gly 20 Phe Pro Gly Leu Glu Trp Ala His His Trp Ile Ser 25 30 Leu Pro Ile Phe Val Gly Tyr Leu Val Thr Leu Ile Gly Asn Ala Thr 35 40 45 Ile Leu His Leu Val Arg Thr Glu Pro Ser Leu Gln Gln Pro Met Tyr 50 55 60 Tyr Phe Leu Ala Ile Leu Ala Val Thr Asp Leu Gly Leu Cys Met Ser 65 70 75 80 Thr Leu Pro Ser Val Leu Gly Val Leu Trp Phe Asp Ala Arg Arg Val 85 90 95 Gly Leu Val Pro Cys Val Leu Gln Gln His Phe Leu His Ser Phe Ser 100 105 110 Phe Met Glu Ser Ala Val Leu Phe Ala Met Ala Leu Asp Arg Leu Val 115 120 125 Ala Ile Arg Phe Pro Leu His Tyr Ala Ser Val Leu Thr Gly Pro Arg 130 135 140 Val Ala Leu Ala Gly Ala Val Leu Gly Met Arg Ser Ala Ala Ile Thr 145 150 155 160 Ala Ala Pro Ser Leu His Leu Leu Lys Phe Asp Tyr Cys Arg Pro Gly 165 170 175 Ser Leu Ser His Ala Tyr Cys Leu His Gln Asp Met Ile Arg Leu Ala 180 185 190 Cys Ser Asp Thr Arg Phe Asn Arg Leu Tyr Gly Leu Cys Ile Ile Met 195 200 205 Leu Ala Met Gly Ser Asp Val Leu Phe Ile Leu Leu Ser Tyr Ala Val 210 215 220

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Ile 225 Leu Arg Thr Val Leu Ala Ile Ala Ser Ala Gly Glu Arg Leu Lys 230 235 240 Ala Leu Asn Thr Cys Val Ser His Ile Leu Ala Val Leu Cys Phe Tyr 245 250 255 Val Pro Val Leu Gly Leu Ser Ile Val His Arg Phe Gly His His Thr 260 265 270 Ser Pro Leu Val His Ile Leu Met Gly Thr Val Ser Val Leu Phe Pro 275 280 285 Pro Leu Met Asn Pro Val Ile Tyr Ser Ile Lys Thr Gln Gln Ile Arg 290 295 300 Arg Ala Ile Leu Lys Val Val Ser Leu Gly Lys Ile Gln 305 310 315

<210> 1073 <211> 936 <212> DNA <213> Canis familiaris <400> 1073

atgttcaaca gcagtcaatt caatcccaag tattttctgc taactggtct ccctggtctg 60 gaggccctgt acccttggtt tattgtccca ttctgctcca tatatcttgt ggcccttgtg 120 ggcaatagcc tggtcctggc agtgatcagg aaaaacacca ctctgcacca gccgatgtac 180 ctttttctag ctatgctggc ctttgcagaa cttggtgtct ctgcttctac actgcccact 240 gtgttgggca tcttcctttt tggtgccaat gagatctgct ttgaagcctg ccttttacag 300 atgttctcca tacattgctt ttccatcatg gagtcaggag ttctgctggc catgtctgtg 360 gaccgttttg tggccatcta caacccactg aggtacacag ccatcctgac caggccccgt 420 attgctgcta ctggtgctgc acttggactg aagagtgtga tgctcatgtt cccactgcct 480 ttcctcctga agcgtctgcc cttctgtggc cacaatgtcc tctcccactc ctactgcctt 540 cactcagatc taattcagct gccctgtggg gatacacgtc ccaacagcat tctggggctc 600 tgcattgtta cttctacttt tgggctggat tcgctgctca tcatcctctc gtatgtgctg 660

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atcctctaca cagtgctggg cattacctct ggggagggaa ggtgtaaggc cctcaacaca 720 tgtgtgtcac atatgtgtgc agtgcttgtg tactatgtgc ccatgatcag cgtggctctg 780 gtgcaccgct tcatgaagca cactgcacct gctctccgtc tactcctggc caacatctat 840 cttctggtgc ctcctgtgct caaccccatc atctacagtg ttaagacaaa acagattcgc 900 caggggctca tccaactctt tcttccaaga aaataa 936

<210> 1074 <211> 311 <212> PRT <213> Canis familiaris

<400> 1074 Ser Ser 5 Gln Phe Asn Pro Lys Tyr Phe Leu Leu Thr Gly Met 1 Phe Asn 10 15 Leu Pro Gly Leu Glu Ala Leu Tyr Pro Trp Phe Ile Val Pro Phe Cys 20 25 30 Ser Ile Tyr Leu Val Ala Leu Val Gly Asn Ser Leu Val Leu Ala Val 35 40 45 Ile Arg Lys Asn Thr Thr Leu His Gln Pro Met Tyr Leu Phe Leu Ala 50 55 60 Met Leu Ala Phe Ala Glu Leu Gly Val Ser Ala Ser Thr Leu Pro Thr 65 70 75 80 Val Leu Gly Ile Phe Leu Phe Gly Ala Asn Glu Ile Cys Phe Glu Ala 85 90 95 Cys Leu Leu Gln Met Phe Ser Ile His Cys Phe Ser Ile Met Glu Ser 100 105 110 Gly Val Leu Leu Ala Met Ser Val Asp Arg Phe Val Ala Ile Tyr Asn 115 120 125 Pro Leu Arg Tyr Thr Ala Ile Leu Thr Arg Pro Arg Ile Ala Ala Thr 130 135 140

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Gly 145 Ala Ala Leu Gly Leu 150 Lys Ser Val Met Leu Met Phe Pro Leu Pro 155 160 Phe Leu Leu Lys Arg Leu Pro Phe Cys Gly His Asn Val Leu Ser His 165 170 175 Ser Tyr Cys Leu His Ser Asp Leu Ile Gln Leu Pro Cys Gly Asp Thr 180 185 190 Arg Pro Asn Ser Ile Leu Gly Leu Cys Ile Val Thr Ser Thr Phe Gly 195 200 205 Leu Asp Ser Leu Leu Ile Ile Leu Ser Tyr Val Leu Ile Leu Tyr Thr 210 215 220 Val Leu Gly Ile Thr Ser Gly Glu Gly Arg Cys Lys Ala Leu Asn Thr 225 230 235 240 Cys Val Ser His Met Cys Ala Val Leu Val Tyr Tyr Val Pro Met Ile 245 250 255 Ser Val Ala Leu Val His Arg Phe Met Lys His Thr Ala Pro Ala Leu 260 265 270 Arg Leu Leu Leu Ala Asn Ile Tyr Leu Leu Val Pro Pro Val Leu Asn 275 280 285 Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Arg Gln Gly Leu Ile 290 295 300 Gln Leu Phe Leu Pro Arg Lys

305 310 <210> 1075 <211> 954 <212> DNA <213> Canis familiaris <400> 1075

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atgaagaact ccaatagttc tttggagtct ttacctacaa ctttcattct ggttggcatc 60 ccagggctgg aggcagagca catttggata tccatcccct tctgcctgat gtatattatc 120 atcttccttg ggaatggcac cattcttcat gtcatcagaa cagaccccgc cttgcaccag 180 cccatgtacc tctttcttgc catgttggcc ctggctgaag ttggtgtctc tgcaacaact 240 ctgcctacag ttctaggcat cttccttttt ggcaccactg agattaattt tgatgcctgc 300 ctttttcaga tgttcttcat ccattctttc tccattatgg agtcagctgt gttgctggcc 360 atgtctgtgg accgatttgt ggccatccat aatccactgc gctatacagc catcctcacc 420 ctgccccgta tatttggcac aggaatgatc atggggctga aaagcattat tctcatggcc 480 ccattaccca tgctattaag gcatctgccc ttctgtggcc ataatgtcct tgcgcattcc 540 tattgcctcc accccaacct tatccatcta ccttgtgggg atgtttctat caacaatatc 600 tatgggcttt tcattgttac ctctactttt gggctggatt cactgcttat tgtgatctcc 660 tatcggctca tactccacac tgtactgagt atcactactg ggaaggggag gaggaaggca 720 ctcaacactt gtggctcaca tatctgtgct gtactcactt actatgtgcc tatgattggc 780 ttatctatgg tgcatcgcct tggattccat gtgtcccctt tggtgcacgc tatgatggcc 840 aatgcttatc tcttcttccc acctgttgtc aaccccattg tctacagcat taagaccaaa 900 gagatccatt gtggcattgt acgaatgctc tcacagaaaa aagcaagaat ttaa 954

<210> 1076 <211> 317 <212> PRT <213> Canis familiaris

<400> 1076 Phe 15 Ile Met 1 Lys Asn Ser Asn 5 Ser Ser Leu Glu Ser 10 Leu Pro Thr Thr Leu Val Gly Ile Pro Gly Leu Glu Ala Glu His Ile Trp Ile Ser Ile 20 25 30 Pro Phe Cys Leu Met Tyr Ile Ile Ile Phe Leu Gly Asn Gly Thr Ile 35 40 45 Leu His Val Ile Arg Thr Asp Pro Ala Leu His Gln Pro Met Tyr Leu Page 1207

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50 55 60 Phe Leu Ala Met Leu Ala Leu Ala Glu Val Gly Val Ser Ala Thr Thr 65 70 75 80 Leu Pro Thr Val Leu Gly Ile Phe Leu Phe Gly Thr Thr Glu Ile Asn 85 90 95 Phe Asp Ala Cys Leu Phe Gln Met Phe Phe Ile His Ser Phe Ser Ile 100 105 110 Met Glu Ser Ala Val Leu Leu Ala Met Ser Val Asp Arg Phe Val Ala 115 120 125 Ile His Asn Pro Leu Arg Tyr Thr Ala Ile Leu Thr Leu Pro Arg Ile 130 135 140 Phe Gly Thr Gly Met Ile Met Gly Leu Lys Ser Ile Ile Leu Met Ala 145 150 155 160 Pro Leu Pro Met Leu Leu Arg His Leu Pro Phe Cys Gly His Asn Val 165 170 175 Leu Ala His Ser Tyr Cys Leu His Pro Asn Leu Ile His Leu Pro Cys 180 185 190 Gly Asp Val Ser Ile Asn Asn Ile Tyr Gly Leu Phe Ile Val Thr Ser 195 200 205 Thr Phe Gly Leu Asp Ser Leu Leu Ile Val Ile Ser Tyr Arg Leu Ile 210 215 220 Leu His Thr Val Leu Ser Ile Thr Thr Gly Lys Gly Arg Arg Lys Ala 225 230 235 240 Leu Asn Thr Cys Gly Ser His Ile Cys Ala Val Leu Thr Tyr Tyr Val 245 250 255 Pro Met Ile Gly Leu Ser Met Val His Arg Leu Gly Phe His Val Ser

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069269_0225_SL.TXT 265 270

Pro Leu Val His Ala Met Met Ala Asn Ala Tyr Leu Phe Phe Pro Pro 275 280 285

Val Val Asn Pro Ile Val Tyr Ser Ile Lys Thr Lys Glu Ile His Cys 290 295 300

Gly Ile Val Arg Met Leu Ser Gln Lys Lys Ala Arg Ile

305 310 315 <210> 1077 <211> 948 <212> DNA <213> Canis familiaris <400> 1077

atgcctgagg tcactaatac cacccaagct cccttctact tcatcctcac gggcatccct 60 ggatttgagg ctttccacat ctggatctcc atccccttct gctgcctcta taccatctcc 120 atcgtgggga acaccaccat tctcgctgtc atccgcacag agccatccct ccaccagccc 180 atgtacctgt ttctctccat gctggccctg actgacctgg gcctcaccct cactaccttg 240 cccacagtca tgcagcttct ctggttcaac attcccaaga tcagctttga agcttgcttt 300 gcccaattct tcttcctcca tggattctcc ttcatggaat cttcagtcct attggccatg 360 tcctttgatc gctatgtagc catctgccgc cccctccatt atgacaccat cctcaccagc 420 gaagtcattg gcaggattgg gttggccatc attggccgct gtatcctggc tgttctccct 480 tcccttttcc tactcaagcg cctgcctttc tgccactccc atcttctctc tcactcctat 540 tgcctccacc aggatatgat ccgcctggtc tgtgctgaca tccgggtcaa cagctggtat 600 ggatttgctc tagttttgct cattattgtc atggaccctc tgctcatcat tctctcctac 660 acgttcattc tgaaaaatat cttgggcaca gcctcctgga ctgagcggct ccgggctctc 720 aataactgtc tatcccacat tctggctgtt ctggtgcttt atgtccccat gattggagta 780 tccatgaccc atcgatttgc caagcatgcc tctccactgg tccatgttat catggccaat 840 gtctacctgt tggcacctcc tgtgatgaac cccatcattt acagtgtcaa gactaagcaa 900 atccgccagg gaatcttcca tgtacttttc caaaggaaag tgtactaa 948

Page 1209

069269_0225_SL.TXT <210> 1078 <211> 315 <212> PRT <213> Canis familiaris

<400> 1078 Met 1 Pro Glu Val Thr 5 Asn Thr Thr Gln Ala Pro Phe Tyr Phe Ile Leu 10 15 Thr Gly Ile Pro Gly Phe Glu Ala Phe His Ile Trp Ile Ser Ile Pro 20 25 30 Phe Cys Cys Leu Tyr Thr Ile Ser Ile Val Gly Asn Thr Thr Ile Leu 35 40 45 Ala Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Tyr Leu Phe 50 55 60 Leu Ser Met Leu Ala Leu Thr Asp Leu Gly Leu Thr Leu Thr Thr Leu 65 70 75 80 Pro Thr Val Met Gln Leu Leu Trp Phe Asn Ile Pro Lys Ile Ser Phe 85 90 95 Glu Ala Cys Phe Ala Gln Phe Phe Phe Leu His Gly Phe Ser Phe Met 100 105 110 Glu Ser Ser Val Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Arg Pro Leu His Tyr Asp Thr Ile Leu Thr Ser Glu Val Ile Gly 130 135 140 Arg Ile Gly Leu Ala Ile Ile Gly Arg Cys Ile Leu Ala Val Leu Pro 145 150 155 160 Ser Leu Phe Leu Leu Lys Arg Leu Pro Phe Cys His Ser His Leu Leu 165 170 175

Page 1210

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Ser His Ser Tyr 180 Cys Leu His Gln Asp Met 185 Ile Arg Leu Val 190 Cys Ala Asp Ile Arg Val Asn Ser Trp Tyr Gly Phe Ala Leu Val Leu Leu Ile 195 200 205 Ile Val Met Asp Pro Leu Leu Ile Ile Leu Ser Tyr Thr Phe Ile Leu 210 215 220 Lys Asn Ile Leu Gly Thr Ala Ser Trp Thr Glu Arg Leu Arg Ala Leu 225 230 235 240 Asn Asn Cys Leu Ser His Ile Leu Ala Val Leu Val Leu Tyr Val Pro 245 250 255 Met Ile Gly Val Ser Met Thr His Arg Phe Ala Lys His Ala Ser Pro 260 265 270 Leu Val His Val Ile Met Ala Asn Val Tyr Leu Leu Ala Pro Pro Val 275 280 285 Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Arg Gln Gly 290 295 300 Ile Phe His Val Leu Phe Gln Arg Lys Val Tyr 305 310 315

<210> 1079 <211> 954 <212> DNA <213> Canis familiaris <400> 1079

atgtccaagg tgtctaacag cacccaagtc cccttctact ttatcctcac gggcatccct 60 ggatttgagg ctttccacat ctggatctcc atccccttct gctgcctcta taccatctcc 120 atcgtgggga acaccaccat tctcgctgtc atccgcacag agccatccct ccaccagccc 180 atgtacctat ttctctccat gctggccctg actgacctgg gcctcaccct caccaccttg 240 cccacagtca tgcagcttct ctggttcaac attcccaaga tcagctttga agcttgcttt 300

Page 1211

069269_0225_SL.TXT gcacaggtat ttttcattca tacattctct ttcatggaat cttcagtcct attggccatg 360 tcctttgatc gctatgtagc catctgtcgc cccctccatt atgacaccat cctcaccagc 420 gaagtcattg gcaggattgg gttggccatc attggccgct gtatcctggc tgttctccct 480 tcccttttcc tactcaagcg cctgcctttc tgccactccc atcttctctc tcactcctat 540 tgcctccacc aggatatgat ccgcctggtc tgtgctgaca tccgggtcaa cagctggtat 600 ggatttgctc tggttttgct cattattgtc atggaccctc tgctcatcat tctctcctac 660 acgttcatcc tgaaaaatat cttgggcaca gcctcttgga ctgagcggct ccgggctctc 720 aataactgtc tatcccacat tctggctgtt ctggtgcttt atgtccccat gattggagta 780 tccatgaccc atcgatttgc caagcatgcc tctccactgg tccatgttat catggccaat 840 gtctacctgt tggcacctcc tgtgatgaac cccatcattt acagtgtcaa gactaagcag 900 atccgccagg gaattatcca cctcatttcc caaagaaata tgtgcttaaa atga 954 <210> 1080 <211> 317 <212> PRT <213> Canis familiaris <400> 1080 Met Ser Lys Val Ser Asn Ser Thr Gln Val Pro Phe Tyr Phe Ile Leu 1 5 10 15 Thr Gly Ile Pro Gly Phe Glu Ala Phe His Ile Trp Ile Ser Ile Pro 20 25 30 Phe Cys Cys Leu Tyr Thr Ile Ser Ile Val Gly Asn Thr Thr Ile Leu 35 40 45 Ala Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Tyr Leu Phe 50 55 60 Leu Ser Met Leu Ala Leu Thr Asp Leu Gly Leu Thr Leu Thr Thr Leu 65 70 75 80 Pro Thr Val Met Gln Leu Leu Trp Phe Asn Ile Pro Lys Ile Ser Phe 85 90 95

Page 1212

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Glu Ala Cys Phe 100 Ala Gln Val Phe Phe Ile His Thr Phe Ser Phe Met 105 110 Glu Ser Ser Val Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Arg Pro Leu His Tyr Asp Thr Ile Leu Thr Ser Glu Val Ile Gly 130 135 140 Arg Ile Gly Leu Ala Ile Ile Gly Arg Cys Ile Leu Ala Val Leu Pro 145 150 155 160 Ser Leu Phe Leu Leu Lys Arg Leu Pro Phe Cys His Ser His Leu Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Met Ile Arg Leu Val Cys Ala 180 185 190 Asp Ile Arg Val Asn Ser Trp Tyr Gly Phe Ala Leu Val Leu Leu Ile 195 200 205 Ile Val Met Asp Pro Leu Leu Ile Ile Leu Ser Tyr Thr Phe Ile Leu 210 215 220 Lys Asn Ile Leu Gly Thr Ala Ser Trp Thr Glu Arg Leu Arg Ala Leu 225 230 235 240 Asn Asn Cys Leu Ser His Ile Leu Ala Val Leu Val Leu Tyr Val Pro 245 250 255 Met Ile Gly Val Ser Met Thr His Arg Phe Ala Lys His Ala Ser Pro 260 265 270 Leu Val His Val Ile Met Ala Asn Val Tyr Leu Leu Ala Pro Pro Val 275 280 285 Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Arg Gln Gly 290 295 300

Page 1213

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Ile Ile His Leu Ile Ser Gln Arg Asn Met Cys Leu Lys 305 310 315 <210> 1081 <211> 945 <212> DNA <213> Canis familiaris <400> 1081

atgggagctg aaagcaatga aagtcttgac gtcctatctg tcttcctaac tggcatccca 60 ggattagagt cccagcatgg ctggctttcc attcccttct ccactatgta tgttgtggcc 120 attgtgggta acagcctaat catgatagca gtgcaggagg accctgtgct acatgagccc 180 atgtacctgt ttctctccat gctggctgtg actgaggtgg gtgtttctgt gtctacactg 240 cccactgtca tgggtattct ttggtttgat gcccaccaga tcgattttga tggctgcctg 300 gctcagatgt tcttcatcca caccttctct tgtatggagt caggggtcct tttggccatg 360 agttatgacc gctttgtagc catctataat ccactgcgat atactgccat cctaaccctg 420 ccccgtatca tctgcatggg tctgggaatc acactgaaga gtgtgacact tatggcccca 480 cttcccatcc ttttgaagca actgccttat tgccacacta atgtcctctc ccattcctac 540 tgtctccact cagacttgat ccagctgcct tgtgctgata ctaagctcaa tagtattcta 600 ggcttggcca ttgtcctggc cacttttggg ctggactcac tgctcattgt ggtctcttat 660 gtgctgattc tttacactgt gctgggcatt gcttctgagg agggacggtg gaaggccctc 720 aacacgtgtg tatcacatat gtgtgcagtg cttgtgtact acgtgcctat gattggtgtg 780 tctgtgatgc atcgtgctgc caagcatgcc tcacccctgg tccatacact catgtctagc 840 atataccttt ttgtgccccc tgtgctcaat cccatcatct acagtgtcaa gaccaagcca 900 atccgacagg gaattttcac cttgttttct tgcaagagga aatag 945

<210> 1082 <211> 314 <212> PRT <213> Canis familiaris <400> 1082

Met Gly Ala Glu Ser Asn Glu Ser Leu Asp Val Leu Ser Val Phe Leu 1 5 10 15

Page 1214

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Thr Gly Ile Pro 20 Gly Leu Glu Ser Gln His Gly Trp Leu Ser Ile Pro 25 30 Phe Ser Thr Met Tyr Val Val Ala Ile Val Gly Asn Ser Leu Ile Met 35 40 45 Ile Ala Val Gln Glu Asp Pro Val Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ser Met Leu Ala Val Thr Glu Val Gly Val Ser Val Ser Thr Leu 65 70 75 80 Pro Thr Val Met Gly Ile Leu Trp Phe Asp Ala His Gln Ile Asp Phe 85 90 95 Asp Gly Cys Leu Ala Gln Met Phe Phe Ile His Thr Phe Ser Cys Met 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ser Tyr Asp Arg Phe Val Ala Ile 115 120 125 Tyr Asn Pro Leu Arg Tyr Thr Ala Ile Leu Thr Leu Pro Arg Ile Ile 130 135 140 Cys Met Gly Leu Gly Ile Thr Leu Lys Ser Val Thr Leu Met Ala Pro 145 150 155 160 Leu Pro Ile Leu Leu Lys Gln Leu Pro Tyr Cys His Thr Asn Val Leu 165 170 175 Ser His Ser Tyr Cys Leu His Ser Asp Leu Ile Gln Leu Pro Cys Ala 180 185 190 Asp Thr Lys Leu Asn Ser Ile Leu Gly Leu Ala Ile Val Leu Ala Thr 195 200 205 Phe Gly Leu Asp Ser Leu Leu Ile Val Val Ser Tyr Val Leu Ile Leu 210 215 220

Page 1215

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Tyr Thr 225 Val Leu Gly Ile Ala Ser Glu Glu Gly Arg Trp Lys Ala Leu 230 235 240 Asn Thr Cys Val Ser His Met Cys Ala Val Leu Val Tyr Tyr Val Pro 245 250 255 Met Ile Gly Val Ser Val Met His Arg Ala Ala Lys His Ala Ser Pro 260 265 270 Leu Val His Thr Leu Met Ser Ser Ile Tyr Leu Phe Val Pro Pro Val 275 280 285 Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Pro Ile Arg Gln Gly 290 295 300 Ile Phe Thr Leu Phe Ser Cys Lys Arg Lys

305 310 <210> 1083 <211> 945 <212> DNA <213> Canis familiaris <400> 1083

atgttgagct tcaatgatac ccccttccat ccagccacac tccagctgac aggcattccg 60 gggatgcaga caggccatgc ctgggttgcc ctggctttct gcatcctcta cctaatttcc 120 atcataggca acctcagcat cctcactctg gtgattcggg agcctgcgct gcaccagccc 180 atgtactact tcctctctat gctgtctctc aacgatctgg gagtgtcctt ctctacactt 240 cccactgtgc ttgctacctt ttgtttcaac taccaccatg ttggcttcga tgcctgctta 300 gttcagatgt tcttcatcca cactttctct ttcatggaat caggcatatt gctggccatg 360 agctttgatc gctttgtggc tatttgtgac ccattacgat atgccactgt gctcaccaac 420 agccgcatct tggctatggg cctgggcatc cttgccaaga gtttcatcac tctcttccct 480 ttcccttttc tggtaaaacg actgcccttc tgcaagggca gaattttgca tcattcatac 540 tgtctccatc cagatctcat gaaagtggcc tgtggagaca tccatgttaa caacatctat 600

Page 1216

069269_0225_SL.TXT gggctttttg tggtcatttt cacctatggc atagactcag tgtttatcct gctttcctat gcattgattc tgagagccgt gctggccatc gcatcccagg agcaacggct caaagcactc aacacctgca tgtcacacat ctgtgcagtg ctggcttttt atgtgcccat aattgctgtc tccatgatcc atcgtttctg gaaaagtgcc ccatctgttg ttcatgtcat gatgtccaat gtctacctgt ttgtaccccc cgtgctcaac ccgatcatct acagtgtgaa gacaaaggag atacgcagag ggatcttcaa agtcctctat aaatcccaga gctga

660

720

780

840

900

945 <210> 1084 <211> 314 <212> PRT <213> Canis familiaris <400> 1084

Met 1 Leu Ser Phe Asn Asp Thr Pro Phe His Pro Ala Thr Leu Gln Leu 5 10 15 Thr Gly Ile Pro Gly Met Gln Thr Gly His Ala Trp Val Ala Leu Ala 20 25 30 Phe Cys Ile Leu Tyr Leu Ile Ser Ile Ile Gly Asn Leu Ser Ile Leu 35 40 45 Thr Leu Val Ile Arg Glu Pro Ala Leu His Gln Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ser Leu Asn Asp Leu Gly Val Ser Phe Ser Thr Leu 65 70 75 80 Pro Thr Val Leu Ala Thr Phe Cys Phe Asn Tyr His His Val Gly Phe 85 90 95 Asp Ala Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Ser Phe Met 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Phe Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg Tyr Ala Thr Val Leu Thr Asn Ser Arg Ile Leu

Page 1217

130 135 069269_0225_SL.TXT 140 Ala Met Gly Leu Gly Ile Leu Ala Lys Ser Phe Ile Thr Leu Phe Pro 145 150 155 160 Phe Pro Phe Leu Val Lys Arg Leu Pro Phe Cys Lys Gly Arg Ile Leu 165 170 175 His His Ser Tyr Cys Leu His Pro Asp Leu Met Lys Val Ala Cys Gly 180 185 190 Asp Ile His Val Asn Asn Ile Tyr Gly Leu Phe Val Val Ile Phe Thr 195 200 205 Tyr Gly Ile Asp Ser Val Phe Ile Leu Leu Ser Tyr Ala Leu Ile Leu 210 215 220 Arg Ala Val Leu Ala Ile Ala Ser Gln Glu Gln Arg Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Met Ser His Ile Cys Ala Val Leu Ala Phe Tyr Val Pro 245 250 255 Ile Ile Ala Val Ser Met Ile His Arg Phe Trp Lys Ser Ala Pro Ser 260 265 270 Val Val His Val Met Met Ser Asn Val Tyr Leu Phe Val Pro Pro Val 275 280 285 Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Glu Ile Arg Arg Gly 290 295 300 Ile Phe Lys Val Leu Tyr Lys Ser Gln Ser 305 310

<210> 1085 <211> 939 <212> DNA <213> Canis familiaris

Page 1218

069269_0225_SL.TXT <400> 1085 atgggactgt tcaatgtcag tcatcctgct tccttcctcc tgactggcat ccctggtctg 60 gagagctctc actcctggct agcagggccc ctctgtgtga tgtatgccgt ggccctcgga 120 ggcaacactg tgatcctaca ggccgtgcga gtggagccca gtctccacga gcccatgtac 180 tacttcctgt ccatgctgtc cttcagtgac gtggccatgt ccatggccac cctgcccacc 240 gtgctcagaa ccttctgcct caacgcccgc agcattgctt ttgatgcctg tctgatccag 300 atgtttctca ttcattcctt ctccatgatg gagtcaggga ttctgctggc catgagcttt 360 gaccgctatg tggccatttg tgatcctttg cactatgcca ctgtgctcac caatggagtc 420 attgctggaa tcggcgtagc tgtgactgcc cggagcttca tcaccctctt tccccttccc 480 ttcctcttca agaggctgcc tgtctgcaga tccaatgttc tttctcactc ctattgcctg 540 cacccagaca tgatgaagct agcctgtgca gatatcacta tcaacagcat ctatggattc 600 tttgttctta tatccacctt tggcatggac atgtttttta tcttcctctc ctatgtgctc 660 attctgcgtt cagtcatggc catcgcttcc cgcaaggaac gcctgaaagc tctcaacaca 720 tgtgtgtcac atatcttggt tgtattagca ttttatgtac cgatgattgg ggtttctgta 780 gtgcaccgct ttggggagca tgccccacgc tacatacatg tcttcatgtc caacgtttac 840 ctctttgtac ctcctgtgct caaccctctc atttacagcg ccaagacaaa ggagatccgc 900 cgagccattg tccgtatgtt tcaccgcatc aaaatgtga 939 <210> 1086 <211> 312 <212> PRT <213> Canis familiaris <400> 1086

Met 1 Gly Leu Phe Asn Val Ser His Pro Ala Ser Phe Leu Leu Thr Gly 5 10 15 Ile Pro Gly Leu Glu Ser Ser His Ser Trp Leu Ala Gly Pro Leu Cys 20 25 30 Val Met Tyr Ala Val Ala Leu Gly Gly Asn Thr Val Ile Leu Gln Ala 35 40 45

Page 1219

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Val Arg 50 Val Glu Pro Ser Leu His 55 Glu Pro Met Tyr Tyr Phe Leu 60 Ser Met Leu Ser Phe Ser Asp Val Ala Met Ser Met Ala Thr Leu Pro Thr 65 70 75 80 Val Leu Arg Thr Phe Cys Leu Asn Ala Arg Ser Ile Ala Phe Asp Ala 85 90 95 Cys Leu Ile Gln Met Phe Leu Ile His Ser Phe Ser Met Met Glu Ser 100 105 110 Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asp 115 120 125 Pro Leu His Tyr Ala Thr Val Leu Thr Asn Gly Val Ile Ala Gly Ile 130 135 140 Gly Val Ala Val Thr Ala Arg Ser Phe Ile Thr Leu Phe Pro Leu Pro 145 150 155 160 Phe Leu Phe Lys Arg Leu Pro Val Cys Arg Ser Asn Val Leu Ser His 165 170 175 Ser Tyr Cys Leu His Pro Asp Met Met Lys Leu Ala Cys Ala Asp Ile 180 185 190 Thr Ile Asn Ser Ile Tyr Gly Phe Phe Val Leu Ile Ser Thr Phe Gly 195 200 205 Met Asp Met Phe Phe Ile Phe Leu Ser Tyr Val Leu Ile Leu Arg Ser 210 215 220 Val Met Ala Ile Ala Ser Arg Lys Glu Arg Leu Lys Ala Leu Asn Thr 225 230 235 240 Cys Val Ser His Ile Leu Val Val Leu Ala Phe Tyr Val Pro Met Ile 245 250 255

Page 1220

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Gly Val Ser Val Val His Arg Phe Gly Glu 265 His Ala Pro Arg 270 Tyr Ile 260 His Val Phe Met Ser Asn Val Tyr Leu Phe Val Pro Pro Val Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Ala Lys Thr Lys Glu Ile Arg Arg Ala Ile Val 290 295 300 Arg Met Phe His Arg Ile Lys Met 305 310

<210> 1087 <211> 957 <212> DNA <213> Canis familiaris <400> 1087

atgtctgcca tgatcatttt caacctgagc aattacaacc caggaccctt cattctggtg 60 ggaatccccg gcctggagca ttgccatgtg tggattggga ttcccttctg tatcatctat 120 gttgtggccc tcgtgggaaa ctgtaccctt ctctacctca tcacagtgga acgtagcctt 180 catgaaccca tgtttttctt tctctccatg ctggccatga ctgatctcat cctgtccaca 240 gctggtgttc ccaaaacact cagtatcttt tggcttgggg ctcgagaaat cacattccca 300 gggtgtctta cacaaatgtt cttcctccac tatagctttg tcctagattc agccatcttg 360 atggccatgg catttgatcg ctatgtggcc atctgctccc ccctgagata taccactatt 420 ctgaccccca ggaccatcac caagattgca gtaggcatct cctctcgaag cttctgcatc 480 attctgccag ttatattctt gcttacacgt ttgcctttct gcaggacaca catcatacca 540 cacacatatt gtgagcacat aggtgtggcc cggctcgcct gtgctgacat ctccatcaac 600 atctggtatg gcttttgtgt tcccatcatg acagtcatct cagatgtgat tctcattgcc 660 gtttcttaca ccctcatcct ctgtgcggtc ttccgcctgc cctcccgaga tgcccgccag 720 aaggcccttg gcacctgtgg ttcccatgtc tgtgtcatcc tcatgtttta tacacctgct 780 tttttctcca tccttgctca tcgttttgga cacaatgtct cccgcacttt ccacatcatg 840 tttgccaatc tctacattgt tattcctcct gcactcaacc ccattgtcta tggagtgaag 900

Page 1221

957

069269_0225_SL.TXT accaagcaga tcagagataa ggtcatcctt ttgttttcta ccaagggttc agaatga <210> 1088 <211> 318 <212> PRT <213> Canis familiaris

<400> 1088 Met 1 Ser Ala Met Ile 5 Ile Phe Asn Leu Ser Asn Tyr Asn Pro Gly Pro 10 15 Phe Ile Leu Val Gly Ile Pro Gly Leu Glu His Cys His Val Trp Ile 20 25 30 Gly Ile Pro Phe Cys Ile Ile Tyr Val Val Ala Leu Val Gly Asn Cys 35 40 45 Thr Leu Leu Tyr Leu Ile Thr Val Glu Arg Ser Leu His Glu Pro Met 50 55 60 Phe Phe Phe Leu Ser Met Leu Ala Met Thr Asp Leu Ile Leu Ser Thr 65 70 75 80 Ala Gly Val Pro Lys Thr Leu Ser Ile Phe Trp Leu Gly Ala Arg Glu 85 90 95 Ile Thr Phe Pro Gly Cys Leu Thr Gln Met Phe Phe Leu His Tyr Ser 100 105 110 Phe Val Leu Asp Ser Ala Ile Leu Met Ala Met Ala Phe Asp Arg Tyr 115 120 125 Val Ala Ile Cys Ser Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro Arg 130 135 140 Thr Ile Thr Lys Ile Ala Val Gly Ile Ser Ser Arg Ser Phe Cys Ile 145 150 155 160 Ile Leu Pro Val Ile Phe Leu Leu Thr Arg Leu Pro Phe Cys Arg Thr 165 170 175

Page 1222

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His Ile Ile Pro His Thr Tyr Cys Glu His Ile Gly Val Ala Arg Leu 180 185 190 Ala Cys Ala Asp Ile Ser Ile Asn Ile Trp Tyr Gly Phe Cys Val Pro 195 200 205 Ile Met Thr Val Ile Ser Asp Val Ile Leu Ile Ala Val Ser Tyr Thr 210 215 220 Leu Ile Leu Cys Ala Val Phe Arg Leu Pro Ser Arg Asp Ala Arg Gln 225 230 235 240 Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Met Phe 245 250 255 Tyr Thr Pro Ala Phe Phe Ser Ile Leu Ala His Arg Phe Gly His Asn 260 265 270 Val Ser Arg Thr Phe His Ile Met Phe Ala Asn Leu Tyr Ile Val Ile 275 280 285 Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile 290 295 300 Arg Asp Lys Val Ile Leu Leu Phe Ser Thr Lys Gly Ser Glu 305 310 315

<210> 1089 <211> 942 <212> DNA <213> Canis familiaris <400> 1089 atgtacaacc tgagtagcta caacacaggt gacttcaccc tcctgggcat ccctggcctt gagcagtacc acgtctggat cagcatcccc ttctgcttta tctatctcgt ggccattgtg ggcaacagta tcctcctcta cctcattgcc gtggagcgga gtcttcacgc acccatgttc tttttccttt ccatgctagc cattacagat gtgatcttgt ctaccacatg tgtccccaaa tcccttaccg tcttctggct tggtccccag aaaatcagtt ttcctggttg cctcacccag

120

180

240

300

Page 1223

069269_0225_SL.TXT

ttattctttc tgcattatag ctttgtcctg gactcagcta tactcctggc catggcattt 360 gatcgctatg tggccatctg cttccccttg agatataccg ctattctgac ctccaggacc 420 actgtcaaaa ttgttgtggg aatttccttc agaagtttct gcatttttgc tccatgtgtt 480 tttcttgtaa atcgtctacc tttttgcggg acacgcatca taccacacac atactgtgag 540 cacataggtg tggcccggct cgcctgtgct gacatctcca tcaacatctg gtatggcttt 600 tgtgttccca tcatgacagt catctcagat gtgattctca ttgccgtttc ttacaccctc 660 atcctctgtg cggtcttccg cctgccctcc caagatgccc gccagaaggc ccttggcacc 720 tgtggttccc atgtctgtgt catcctcatg ttctatatac cagcattctt ctccatcctt 780 gcccatcgct ttggccataa tgtcccccgg acttttcaca tcctctttgc caacctctat 840 gtagttatgc cacctgcact caatcctatt gtctacggag taaagaccaa gagtatctgg 900 gacaaagtcg ttctcttgct cttccctcgt gggactcaat ga 942

<210> 1090 <211> 313 <212> PRT <213> Canis familiaris

<400> 1090 Ser Ser 5 Tyr Asn Thr Gly Asp Phe Thr Leu Leu Gly Met Tyr 1 Asn Leu 10 15 Ile Pro Gly Leu Glu Gln Tyr His Val Trp Ile Ser Ile Pro Phe Cys 20 25 30 Phe Ile Tyr Leu Val Ala Ile Val Gly Asn Ser Ile Leu Leu Tyr Leu 35 40 45 Ile Ala Val Glu Arg Ser Leu His Ala Pro Met Phe Phe Phe Leu Ser 50 55 60 Met Leu Ala Ile Thr Asp Val Ile Leu Ser Thr Thr Cys Val Pro Lys 65 70 75 80 Ser Leu Thr Val Phe Trp Leu Gly Pro Gln Lys Ile Ser Phe Pro Gly 85 90 95

Page 1224

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Cys Leu Thr Gln Leu Phe Phe Leu His Tyr Ser Phe Val Leu Asp Ser 100 105 110 Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Phe 115 120 125 Pro Leu Arg Tyr Thr Ala Ile Leu Thr Ser Arg Thr Thr Val Lys Ile 130 135 140 Val Val Gly Ile Ser Phe Arg Ser Phe Cys Ile Phe Ala Pro Cys Val 145 150 155 160 Phe Leu Val Asn Arg Leu Pro Phe Cys Gly Thr Arg Ile Ile Pro His 165 170 175 Thr Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Ile Trp Tyr Gly Phe Cys Val Pro Ile Met Thr Val Ile 195 200 205 Ser Asp Val Ile Leu Ile Ala Val Ser Tyr Thr Leu Ile Leu Cys Ala 210 215 220 Val Phe Arg Leu Pro Ser Gln Asp Ala Arg Gln Lys Ala Leu Gly Thr 225 230 235 240 Cys Gly Ser His Val Cys Val Ile Leu Met Phe Tyr Ile Pro Ala Phe 245 250 255 Phe Ser Ile Leu Ala His Arg Phe Gly His Asn Val Pro Arg Thr Phe 260 265 270 His Ile Leu Phe Ala Asn Leu Tyr Val Val Met Pro Pro Ala Leu Asn 275 280 285 Pro Ile Val Tyr Gly Val Lys Thr Lys Ser Ile Trp Asp Lys Val Val 290 295 300

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069269_0225_SL.TXT

Leu Leu Leu Phe Pro Arg Gly Thr Gln 305 310 <210> 1091 <211> 957 <212> DNA <213> Canis familiaris <400> 1091

atgtctgcca tgatcatttt caacctgagc aattacaacc caggaccctt cattctggtg 60 ggaatccccg gcctggagca ttgccatgtg tggattggga ttcccttctg tatcatctat 120 gttgtggccc tcgtgggaaa ctgtaccctt ctctacctca tcacagtgga acgtagcctt 180 catgaaccca tgtttttctt tctctccatg ctggccatga ctgatctcat cctgtccaca 240 gctggtgttc ccaaatcact cagtatcttt tggcttgggg ctcgagaaat cacattccca 300 gggtgtctta cacaaatgtt cttccaccac tgtagctttg tcctagattc agccatcttg 360 atggccatgg catttgatcg ctatgtggcc atctgctccc ccctgagata tgccactatt 420 ctgaccccca ggaccatcac caagattgca gtgggcatct cctgtcgaag cttctgcatc 480 attctgccag ttgtattttt gcttacacgt ttgcctttct gcaggacacg catcatacca 540 cacacatact gtgagcacat aggtgtggcc cggctcgcct gtgctgacat ctccatcaac 600 atctggtatg gcttttgtgt tcccatcatg acagtcatct cagatgtgat tctcattgcc 660 gtttcttaca ccctcatcct ctgtgcggtc ttccgcctgc cctcccgaga tgcccgccag 720 aaggcccttg gcacctgtgg ttcccatgtc tgtgtcatcc tcatgttcta tataccagca 780 ttcttctcca tccttgccca tcgttttggg cataatgtcc ctcgtacatt tcacatcctc 840 tttgccaacc tctatgtagt tatcccacct gcactcaacc ccattgtcta tggagtgaaa 900 accaagcaaa taagagaaag ggtcatcctt ttattttcta ccaagagttc agaatga 957

<210> 1092 <211> 318 <212> PRT <213> Canis familiaris <400> 1092

Met Ser Ala Met Ile Ile Phe Asn Leu Ser Asn Tyr Asn Pro Gly Pro

Page 1226

0 6926 9_02 25_S L.TX T 1 5 10 15 Phe Ile Leu Val Gly Ile Pro Gly Leu Glu His Cys His Val Trp Ile 20 25 30 Gly Ile Pro Phe Cys Ile Ile Tyr Val Val Ala Leu Val Gly Asn Cys 35 40 45 Thr Leu Leu Tyr Leu Ile Thr Val Glu Arg Ser Leu His Glu Pro Met 50 55 60 Phe Phe Phe Leu Ser Met Leu Ala Met Thr Asp Leu Ile Leu Ser Thr 65 70 75 80 Ala Gly Val Pro Lys Ser Leu Ser Ile Phe Trp Leu Gly Ala Arg Glu 85 90 95 Ile Thr Phe Pro Gly Cys Leu Thr Gln Met Phe Phe His His Cys Ser 100 105 110 Phe Val Leu Asp Ser Ala Ile Leu Met Ala Met Ala Phe Asp Arg Tyr 115 120 125 Val Ala Ile Cys Ser Pro Leu Arg Tyr Ala Thr Ile Leu Thr Pro Arg 130 135 140 Thr Ile Thr Lys Ile Ala Val Gly Ile Ser Cys Arg Ser Phe Cys Ile 145 150 155 160 Ile Leu Pro Val Val Phe Leu Leu Thr Arg Leu Pro Phe Cys Arg Thr 165 170 175 Arg Ile Ile Pro His Thr Tyr Cys Glu His Ile Gly Val Ala Arg Leu 180 185 190 Ala Cys Ala Asp Ile Ser Ile Asn Ile Trp Tyr Gly Phe Cys Val Pro 195 200 205 Ile Met Thr Val Ile Ser Asp Val Ile Leu Ile Ala Val Ser Tyr Thr

Page 1227

069269_0225_SL.TXT

210 215 220

Leu 225 Ile Leu Cys Ala Val Phe Arg Leu Pro Ser Arg Asp Ala Arg Gln 230 235 240 Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Met Phe 245 250 255 Tyr Ile Pro Ala Phe Phe Ser Ile Leu Ala His Arg Phe Gly His Asn 260 265 270 Val Pro Arg Thr Phe His Ile Leu Phe Ala Asn Leu Tyr Val Val Ile 275 280 285 Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile 290 295 300 Arg Glu Arg Val Ile Leu Leu Phe Ser Thr Lys Ser Ser Glu 305 310 315

<210> 1093 <211> 942 <212> DNA <213> Canis familiaris <400> 1093

atgtacaacc tgagtagcta caacacaggt gacttcaccc tcctgggcat ccctggcctt 60 gagcagtacc acgtctggat cagcatcccc ttctgcttta tctatctcgt ggccattgtg 120 ggcaacagta tcctcctcta cctcattgcc gtggagcgga gtcttcacgc acccatgttc 180 tttttccttt ccatgctagc cattacagat gtgatcttgt ctaccacatg tgtccccaaa 240 tcccttaccg tcttctggct tggtccccag aaaatcagtt ttcctggttg cctcacccag 300 ttattctttc tgcattatag ctttgtcctg gactcagcta tactcctggc catggcattt 360 gatcgctatg tggccatctg cttcctcttg agatataccg ctattctgac ctccaggacc 420 actgtcaaaa ttgttgtggg aatttccttc agaagtttct gcatttttgc tccatgtgtt 480 tttcttgtaa atcgtctacc tttttgcggg acacgcatca taccacacac atactgtgag 540 cacataggtg tggcccggct cgcctgtgct gacatctcca tcaacatctg gtatggcttt 600

Page 1228

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tgtgttccca tcatgacagt catctcagat gtgattctca ttgccgtttc ttacaccctc 660 atcctctgtg cggtcttccg cctgccctcc caagatgccc gccagaaggc ccttggcacc 720 tgtggttccc atgtctgtgt catcctcatg ttctatatac cagcattctt ctccatcctt 780 gcccatcgct ttggccataa tgtcccccgg acttttcaca tcctctttgc caacctctat 840 gtagttatgc cacctgcact caatcctatt gtctacggag taaagaccaa gagtatctgg 900 gacaaagtcg ttctcttgct cttccctcgt gggactcaat ga 942

<210> 1094 <211> 313 <212> PRT <213> Canis familiaris

<400> 1094 Ser Tyr Asn Thr Gly Asp Phe Thr Leu Leu Gly Met 1 Tyr Asn Leu Ser 5 10 15 Ile Pro Gly Leu Glu Gln Tyr His Val Trp Ile Ser Ile Pro Phe Cys 20 25 30 Phe Ile Tyr Leu Val Ala Ile Val Gly Asn Ser Ile Leu Leu Tyr Leu 35 40 45 Ile Ala Val Glu Arg Ser Leu His Ala Pro Met Phe Phe Phe Leu Ser 50 55 60 Met Leu Ala Ile Thr Asp Val Ile Leu Ser Thr Thr Cys Val Pro Lys 65 70 75 80 Ser Leu Thr Val Phe Trp Leu Gly Pro Gln Lys Ile Ser Phe Pro Gly 85 90 95 Cys Leu Thr Gln Leu Phe Phe Leu His Tyr Ser Phe Val Leu Asp Ser 100 105 110 Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Phe 115 120 125

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Leu Leu 130 Arg Tyr Thr Ala Ile 135 069269_0225_SL.TXT Leu Thr Ser Arg Thr Thr 140 Val Lys Ile Val Val Gly Ile Ser Phe Arg Ser Phe Cys Ile Phe Ala Pro Cys Val 145 150 155 160 Phe Leu Val Asn Arg Leu Pro Phe Cys Gly Thr Arg Ile Ile Pro His 165 170 175 Thr Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Ile Trp Tyr Gly Phe Cys Val Pro Ile Met Thr Val Ile 195 200 205 Ser Asp Val Ile Leu Ile Ala Val Ser Tyr Thr Leu Ile Leu Cys Ala 210 215 220 Val Phe Arg Leu Pro Ser Gln Asp Ala Arg Gln Lys Ala Leu Gly Thr 225 230 235 240 Cys Gly Ser His Val Cys Val Ile Leu Met Phe Tyr Ile Pro Ala Phe 245 250 255 Phe Ser Ile Leu Ala His Arg Phe Gly His Asn Val Pro Arg Thr Phe 260 265 270 His Ile Leu Phe Ala Asn Leu Tyr Val Val Met Pro Pro Ala Leu Asn 275 280 285 Pro Ile Val Tyr Gly Val Lys Thr Lys Ser Ile Trp Asp Lys Val Val 290 295 300 Leu Leu Leu Phe Pro Arg Gly Thr Gln 305 310

<210> 1095 <211> 957 <212> DNA <213> Canis familiaris

Page 1230

069269_0225_SL.TXT <400> 1095

atgtctgcca tgatcatttt caacctgagc aattacaacc caggaccctt cattctggtg 60 ggaatccctg gcctggagca ttgccatgtg tggattggga ttcccttctg tatcatctat 120 gttgtggccc tcgtgggaaa ctgtaccctt ctctacctca tcacagtgga acgtagcctt 180 catgaaccca tgtttttctt tctctccatg ctggccatga ctgatctcat cctgtccaca 240 gctggtgttc ccaaatcact cagtatcttt tggcttgggg ctcgagaaat cacattccca 300 gggtgtctta cacaaatgtt cttccaccac tgtagctttg tcctagattc agccatcttg 360 atggccatgg catttgatcg ctatgtggcc atctgctccc ccctgagata taccactatt 420 ctgaccccca ggaccatcac caagattgca gtgggcatct cctttcgaag cttctgcatc 480 attctgccag ttgtattctt gcttacacgt ttgcctttct gcaggacacg catcatacca 540 cacacatact gtgagcacat aggtgtggcc cggctcgcct gtgctgacat ctccatcaac 600 atctggtatg gcttttgtgt tcccatcatg acagtcatct cagatgtgat tctcattgcc 660 gtttcttaca ccctcatcct ctgtgcggtc ttccgcctgc cctcccgaga tgcccgccag 720 aaggcccttg gcacctgtgg ttcccatgtc tgtgtcatcc tcatgttcta tataccagca 780 ttcttctcca tccttgccca tcgttttggg cataatgtcc ctcgtacatt tcacatcctc 840 tttgccaacc tctatgtagt tatcccacct gcactcaacc ccattgtcta tggagtgaaa 900 accaagcaaa taagagaaag ggtcatcctt ttattttcta ccaagagttc agaatga 957

<210> 1096 <211> 318 <212> PRT <213> Canis familiaris

<400> 1096 Ile Phe Asn Leu Ser Asn Tyr Asn Pro Gly Pro Met 1 Ser Ala Met Ile 5 10 15 Phe Ile Leu Val Gly Ile Pro Gly Leu Glu His Cys His Val Trp Ile 20 25 30 Gly Ile Pro Phe Cys Ile Ile Tyr Val Val Ala Leu Val Gly Asn Cys 35 40 45

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Thr Leu 50 Leu Tyr Leu Ile Thr Val 55 Glu Arg Ser Leu His Glu Pro 60 Met Phe Phe Phe Leu Ser Met Leu Ala Met Thr Asp Leu Ile Leu Ser Thr 65 70 75 80 Ala Gly Val Pro Lys Ser Leu Ser Ile Phe Trp Leu Gly Ala Arg Glu 85 90 95 Ile Thr Phe Pro Gly Cys Leu Thr Gln Met Phe Phe His His Cys Ser 100 105 110 Phe Val Leu Asp Ser Ala Ile Leu Met Ala Met Ala Phe Asp Arg Tyr 115 120 125 Val Ala Ile Cys Ser Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro Arg 130 135 140 Thr Ile Thr Lys Ile Ala Val Gly Ile Ser Phe Arg Ser Phe Cys Ile 145 150 155 160 Ile Leu Pro Val Val Phe Leu Leu Thr Arg Leu Pro Phe Cys Arg Thr 165 170 175 Arg Ile Ile Pro His Thr Tyr Cys Glu His Ile Gly Val Ala Arg Leu 180 185 190 Ala Cys Ala Asp Ile Ser Ile Asn Ile Trp Tyr Gly Phe Cys Val Pro 195 200 205 Ile Met Thr Val Ile Ser Asp Val Ile Leu Ile Ala Val Ser Tyr Thr 210 215 220 Leu Ile Leu Cys Ala Val Phe Arg Leu Pro Ser Arg Asp Ala Arg Gln 225 230 235 240 Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Met Phe 245 250 255

Page 1232

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Tyr Ile Pro Ala Phe Phe Ser Ile Leu 265 Ala His Arg Phe Gly 270 His Asn 260 Val Pro Arg Thr Phe His Ile Leu Phe Ala Asn Leu Tyr Val Val Ile 275 280 285 Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile 290 295 300 Arg Glu Arg Val Ile Leu Leu Phe Ser Thr Lys Ser Ser Glu 305 310 315

<210> 1097 <211> 957 <212> DNA <213> Canis familiaris <400> 1097

atgtctgcca tgatcatttt caacctgagc aattacaacc caggaccctt cattctggtg 60 ggaatccccg gcctggagca ttgctatgtg tggattggga ttcccttctg tatcatctat 120 gttgtggccc tcgtgggaaa ctgtaccctt ctctacctca tcacagtgga acgtagcctt 180 catgaaccca tgtttttctt tctctccatg ctggccatga ctgatctcat cctgtccaca 240 gctggtgttc ccaaatcact cagtatcttt tggcttgggg ctcgagaaat cacattccca 300 gggtgtctta cacaaatgtt cttccaccac tgtagctttg tcctagattc agccatcttg 360 atggccatgg catttgatcg ctatgtggcc atctgctccc ccctgagata taccactatt 420 ctgaccccca ggaccatcac caagattgca gtgggcatct cctttcgaag cttctgcatc 480 atcctgcctg atgtattctt gcttacacgt ttgcctttct gcaggacacg catcatacca 540 cacacatact gtgagcacat aggtgtggcc cggctcgcct gtgctgacat ctccatcaac 600 atctggtatg gcttttgtgt tcccatcatg acagtcatct cagatgtgat tctcattgcc 660 gtttcttaca ccctcatcct ctgtgcggtc ttccgcctgc cctcccgaga tgcccgccag 720 aaggcccttg gcacctgtgg ttcccatgtc tgtgtcatcc tcatgttcta tataccagca 780 ttcttctcca ttcttgccca tcgctttggc cataatgtcc ctcgtacttt tcacatcctc 840 tttgccaacc tctatattgt tattccacct gcactcaacc ccattgtcta tggagtaaag 900

Page 1233

069269_0225_SL.TXT accacacaga tccgacataa ggtcatcctt ttgttttcta ccaagggttc agaatga

957 <210> 1098 <211> 318 <212> PRT <213> Canis familiaris

<400> 1098 Met 1 Ser Ala Met Ile 5 Ile Phe Asn Leu Ser Asn Tyr Asn Pro Gly Pro 10 15 Phe Ile Leu Val Gly Ile Pro Gly Leu Glu His Cys Tyr Val Trp Ile 20 25 30 Gly Ile Pro Phe Cys Ile Ile Tyr Val Val Ala Leu Val Gly Asn Cys 35 40 45 Thr Leu Leu Tyr Leu Ile Thr Val Glu Arg Ser Leu His Glu Pro Met 50 55 60 Phe Phe Phe Leu Ser Met Leu Ala Met Thr Asp Leu Ile Leu Ser Thr 65 70 75 80 Ala Gly Val Pro Lys Ser Leu Ser Ile Phe Trp Leu Gly Ala Arg Glu 85 90 95 Ile Thr Phe Pro Gly Cys Leu Thr Gln Met Phe Phe His His Cys Ser 100 105 110 Phe Val Leu Asp Ser Ala Ile Leu Met Ala Met Ala Phe Asp Arg Tyr 115 120 125 Val Ala Ile Cys Ser Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro Arg 130 135 140 Thr Ile Thr Lys Ile Ala Val Gly Ile Ser Phe Arg Ser Phe Cys Ile 145 150 155 160 Ile Leu Pro Asp Val Phe Leu Leu Thr Arg Leu Pro Phe Cys Arg Thr 165 170 175

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Arg Ile Ile Pro 180 His Thr Tyr Cys Ala Cys Ala 195 Asp Ile Ser Ile Asn 200 Ile Met 210 Thr Val Ile Ser Asp 215 Val Leu 225 Ile Leu Cys Ala Val 230 Phe Arg Lys Ala Leu Gly Thr 245 Cys Gly Ser Tyr Ile Pro Ala 260 Phe Phe Ser Ile Val Pro Arg 275 Thr Phe His Ile Leu 280 Pro Pro 290 Ala Leu Asn Pro Ile 295 Val Arg 305 His Lys Val Ile Leu 310 Leu Phe

Glu His Ile Gly Val Ala Arg Leu 185 190 Ile Trp Tyr Gly Phe 205 Cys Val Pro Ile Leu Ile Ala 220 Val Ser Tyr Thr Leu Pro Ser 235 Arg Asp Ala Arg Gln 240 His Val 250 Cys Val Ile Leu Met 255 Phe Leu 265 Ala His Arg Phe Gly 270 His Asn Phe Ala Asn Leu Tyr 285 Ile Val Ile Tyr Gly Val Lys 300 Thr Thr Gln Ile Ser Thr Lys 315 Gly Ser Glu

<210> 1099 <211> 501 <212> DNA <213> Canis familiaris <400> 1099 ctagagtccc tatatatctg gctttccatc gtggggaatg tcaccattct ggctgtggta tatttcttcc tgtgtgtttt ggccgtcatt ctgggaatct tctggtttgg cgctgggaac cccctcagct ccatttacct ggttgctgtg aaggtggagc atagcctgca tcagcccatg gacctggttc tgtctactat gcccaaaatg attggcctgg atgcctgcct ggctcaagtg

120

180

240

Page 1235

069269_0225_SL.TXT ttcctcatcc actactttgc cacagtggag tccagcatct tccttgctgt aacttttaac 300 cactgtgtag ccatctgtaa cctactctgt tccactacag tatgagtgag cactgtggtg 360 tgatgtttgg gggtggctgc cctcctctgg ggtatactct acattagacc cctgcctttg 420 ataatccacc tgtggctact cctttacaaa gctcatgtca tctcccacgc ctactgtgag 480 cacatggatg tgagcacctt g 501 <210> 1100 <211> 114 <212> PRT <213> Canis familiaris <400> 1100

Leu Glu Ser Leu Tyr Ile Trp Leu Ser Ile Pro Leu Ser Ser Ile Tyr 1 5 10 15

Leu Val Ala Val Val Gly Asn Val Thr Ile Leu Ala Val Val Lys Val 20 25 30

Glu His Ser Leu His Gln Pro Met Tyr Phe Phe Leu Cys Val Leu Ala 35 40 45

Val Ile Asp Leu Val Leu Ser Thr Met Pro Lys Met Leu Gly Ile Phe 50 55 60

Trp Phe Gly Ala Gly Asn Ile Gly Leu Asp Ala Cys Leu Ala Gln Val 65 70 75 80

Phe Leu Ile His Tyr Phe Ala Thr Val Glu Ser Ser Ile Phe Leu Ala 85 90 95

Val Thr Phe Asn His Cys Val Ala Ile Cys Asn Leu Leu Cys Ser Thr 100 105 110

Thr Val <210> 1101 <211> 975 <212> DNA

Page 1236

069269_0225_SL.TXT <213> Canis familiaris

<400> 1101 atgttgggga taccttataa ccacacaatg gaaacccctg ccaccttctt ccttgtgggt 60 atcccaggtt tgcagtcttc acatctttgg ctggctattt cactgagtgc aacgtatatc 120 atatctctgt taggaaacac actcataatg actgttatct ggatggattt cactctacaa 180 gagcccatgt attgctttct gtatgttttg gctgccgttg acattgttat ggcctcctct 240 gttgtaccca agatggtaag catcttcttc tcaggagatg gctccatcag ctttaatgct 300 tgtttcactc agatgtattt tgtccatgca gctacatctg tggagacggg gctactgcta 360 gccatggctt ttgaccgcta tatagccatc tgtaagcccc tacactacaa gagaattctc 420 acacctaaat tgatgctggt aatgagtgtg gccatcacca tcagagctgt catattcatg 480 actccattga gttggatgtt aagtcatctg cctttttgtg gctccaatgt ggttctccat 540 tcctactgtg aacacatagc tgtggccaag ctggcatgtg ctgaccccat gcccagtagt 600 ctctacagtg taattggctc ctccattatt gtgggctctg atgtagccct cattgctgcc 660 tcttatcacc taattctccg ggcagtatgt ggtctggcct caaagaatgc tcagctgaaa 720 gcattaagca catgtggctc tcatgtgggg gttatggctc tgtactatct acctgggatg 780 gcatcaatct atgtggcctg gctagggagg gatacagtgc ctctgcatac tcaagtactg 840 ttagctgatt tgtatctgat cattccaccc accttaaacc ctatcattta tggcctgagg 900 accaaacaaa tacggaagcg aacatggaac ttgctgatga actgcctctt tgaccactcc 960 aagctgggtt cataa 975

<210> 1102 <211> 324 <212> PRT <213> Canis familiaris <400> 1102

Met Leu Gly Ile Pro Tyr Asn His Thr Met Glu Thr Pro Ala Thr Phe 1 5 10 15

Phe Leu Val Gly Ile Pro Gly Leu Gln Ser Ser His Leu Trp Leu Ala 20 25 30

Page 1237

Ile Ser Leu 35 Ser Ala Thr Tyr 069269_0225_SL.TXT Ile Ile Ser Leu Leu Gly 40 45 Asn Thr Leu Ile Met Thr Val Ile Trp Met Asp Phe Thr Leu Gln Glu Pro Met Tyr 50 55 60 Cys Phe Leu Tyr Val Leu Ala Ala Val Asp Ile Val Met Ala Ser Ser 65 70 75 80 Val Val Pro Lys Met Val Ser Ile Phe Phe Ser Gly Asp Gly Ser Ile 85 90 95 Ser Phe Asn Ala Cys Phe Thr Gln Met Tyr Phe Val His Ala Ala Thr 100 105 110 Ser Val Glu Thr Gly Leu Leu Leu Ala Met Ala Phe Asp Arg Tyr Ile 115 120 125 Ala Ile Cys Lys Pro Leu His Tyr Lys Arg Ile Leu Thr Pro Lys Leu 130 135 140 Met Leu Val Met Ser Val Ala Ile Thr Ile Arg Ala Val Ile Phe Met 145 150 155 160 Thr Pro Leu Ser Trp Met Leu Ser His Leu Pro Phe Cys Gly Ser Asn 165 170 175 Val Val Leu His Ser Tyr Cys Glu His Ile Ala Val Ala Lys Leu Ala 180 185 190 Cys Ala Asp Pro Met Pro Ser Ser Leu Tyr Ser Val Ile Gly Ser Ser 195 200 205 Ile Ile Val Gly Ser Asp Val Ala Leu Ile Ala Ala Ser Tyr His Leu 210 215 220 Ile Leu Arg Ala Val Cys Gly Leu Ala Ser Lys Asn Ala Gln Leu Lys 225 230 235 240

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Ala Leu Ser Thr Cys 245 Gly Ser 069269_0225_SL.TXT His Val Gly Val Met Ala 250 Leu Tyr 255 Tyr Leu Pro Gly Met Ala Ser Ile Tyr Val Ala Trp Leu Gly Arg Asp Thr 260 265 270 Val Pro Leu His Thr Gln Val Leu Leu Ala Asp Leu Tyr Leu Ile Ile 275 280 285 Pro Pro Thr Leu Asn Pro Ile Ile Tyr Gly Leu Arg Thr Lys Gln Ile 290 295 300 Arg Lys Arg Thr Trp Asn Leu Leu Met Asn Cys Leu Phe Asp His Ser 305 310 315 320

Lys Leu Gly Ser <210> 1103 <211> 1020 <212> DNA <213> Canis familiaris <400> 1103 atggaactgg atcctgcact gcctgttctc aaccagactg tgctcacctc tgggcctggg 60 ccttttgtcc tgttgggggt gccaggactg cagaccttgc atgcctggct ttcagtgcct 120 gtgtgtctgc tgtacatggc tgctttggca gggaatgccc ttctcttggg gctggtagcc 180 actgacaaga cacttcagac acccatgtac cagctgctgg ggcttctggc agccgcggac 240 ttggttctgg ccacatccac agtgcccaaa gctctggctg tgctctgggg cctgtcaggg 300 gagatctcct tcgcagcctg cctagcccag ctctttgtaa cccatgtgac cttcattgct 360 gagtcttcag tgctcctggc catggccata gaccgctatg tggccatctg tcagcctctg 420 cgctatgggg cactgcttac ccagcgtgtg gtgggcatag tggcagtagc cgcagtgacc 480 cgtggtgcct gtgtcatggc acctccagtg gccttgctcc agagactgcc ttactgtggg 540 cagcgggagc tcccccacac ctactgcgaa cacatgggtg tggctcggct ggcatgtggc 600 gacacacgcc ccaacgtttg gtatggcttg gccaccacat tgctgtctcc agccctggac 660

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ttagggctca ttgctgcttc ctatgccctc attctccgtg ctgtatgtcg cctgccatcc 720 catggtgccc gctgcaaagc cttgggtacc tgtggggcgc atgccagcgt catcactctt 780 ttctacaccc ctgccctctt ctctttcctg gctcaccgtt ttggccgcca cacagtgccc 840 agtcatatcc acatcctcct ggctaacctc tatgtggtgg tgccacctgc ccttaatcct 900 gtggtctatg gagtacgtac ccagcagatt gctcagaggc tccggtactt gcttcggctc 960 tggtgggcaa gggcagtaag ggatgtgggc cccgagaggg cctcccgtgg cagtgaatga 1020

<210> 1104 <211> 339 <212> PRT <213> Canis familiaris <400> 1104

Met 1 Glu Leu Asp Pro 5 Ala Leu Pro Val Leu Asn Gln Thr Val Leu Thr 10 15 Ser Gly Pro Gly Pro Phe Val Leu Leu Gly Val Pro Gly Leu Gln Thr 20 25 30 Leu His Ala Trp Leu Ser Val Pro Val Cys Leu Leu Tyr Met Ala Ala 35 40 45 Leu Ala Gly Asn Ala Leu Leu Leu Gly Leu Val Ala Thr Asp Lys Thr 50 55 60 Leu Gln Thr Pro Met Tyr Gln Leu Leu Gly Leu Leu Ala Ala Ala Asp 65 70 75 80 Leu Val Leu Ala Thr Ser Thr Val Pro Lys Ala Leu Ala Val Leu Trp 85 90 95 Gly Leu Ser Gly Glu Ile Ser Phe Ala Ala Cys Leu Ala Gln Leu Phe 100 105 110 Val Thr His Val Thr Phe Ile Ala Glu Ser Ser Val Leu Leu Ala Met 115 120 125 Ala Ile Asp Arg Tyr Val Ala Ile Cys Gln Pro Leu Arg Tyr Gly Ala

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130 135 140 Leu Leu Thr Gln Arg Val Val Gly Ile Val Ala Val Ala Ala Val Thr 145 150 155 160 Arg Gly Ala Cys Val Met Ala Pro Pro Val Ala Leu Leu Gln Arg Leu 165 170 175 Pro Tyr Cys Gly Gln Arg Glu Leu Pro His Thr Tyr Cys Glu His Met 180 185 190 Gly Val Ala Arg Leu Ala Cys Gly Asp Thr Arg Pro Asn Val Trp Tyr 195 200 205 Gly Leu Ala Thr Thr Leu Leu Ser Pro Ala Leu Asp Leu Gly Leu Ile 210 215 220 Ala Ala Ser Tyr Ala Leu Ile Leu Arg Ala Val Cys Arg Leu Pro Ser 225 230 235 240 His Gly Ala Arg Cys Lys Ala Leu Gly Thr Cys Gly Ala His Ala Ser 245 250 255 Val Ile Thr Leu Phe Tyr Thr Pro Ala Leu Phe Ser Phe Leu Ala His 260 265 270 Arg Phe Gly Arg His Thr Val Pro Ser His Ile His Ile Leu Leu Ala 275 280 285 Asn Leu Tyr Val Val Val Pro Pro Ala Leu Asn Pro Val Val Tyr Gly 290 295 300 Val Arg Thr Gln Gln Ile Ala Gln Arg Leu Arg Tyr Leu Leu Arg Leu 305 310 315 320 Trp Trp Ala Arg Ala Val Arg Asp Val Gly Pro Glu Arg Ala Ser Arg 325 330 335

Gly Ser Glu

Page 1241

069269_0225_SL.TXT <210> 1105 <211> 957 <212> DNA <213> Canis familiaris <400> 1105

atgtcaacct ccaacctcag tgatgacagt cttccagcca tcatgttcct gacaggaatc 60 ccagggctgg agtgggctca tgcctggatt gccatcccct tctgtgccat gtatctggta 120 gcactggctg ggaatgctgc cctcatcctg gtcattgtga cagacagtgc tcttcatgca 180 cccatgtacc tcttcctgtg tcttctctca ttcactgacc tggctctcag ctcaaccacc 240 gtgcccaaaa tgctagccat tttgtggctc catgctggag aaatttcctt tggtggatgc 300 ctggcccaga tgttttgtgt ccattctatc tatgctctgg agtcctcagt tcttctggcc 360 atggcctttg atcgctatgt agctatctgc aacccactga gatacacaac cattcttaac 420 catactgtaa taggcaaaat tggccttgtt ggcctcctcc gcagcgtggc cattgtctcc 480 ccatttatct tcctgctgag gcgactgcct tactgtgatc accatgtcat ggcacataca 540 tactgtgagc acatgggcat cgctcgcctg gcctgtggca acatcactgt caatattgtc 600 tatgggctga ctgtggccct gctggccatg ggtctggatt ccatcctcat tgccatttcc 660 tatggcttta tcctccacgc tgtcttccgc cttccatctc aagatgccag gcacaaggct 720 ctgagtacct gtggctccca cctcggggtc atcctggtct tctacattcc tgccttcttc 780 tccttcctca cccatcgttt tggccagcac cgagttccca agaatgtgca catctttctg 840 gcgaacctct atgtgctggt gcctcctgtg ctcaatccaa tcatctatgg agctaggacc 900 aaggagattc agagtcgact gctgagattc cttcacttgg ggaaaatttt aatgtga 957

<210> 1106 <211> 318 <212> PRT <213> Canis familiaris <400> 1106

Met Ser Thr Ser Asn Leu Ser Asp Asp Ser Leu Pro Ala Ile Met Phe 1 5 10 15

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Leu Thr Gly Ile 20 Pro Gly Leu Glu Trp Ala His Ala Trp Ile Ala Ile 25 30 Pro Phe Cys Ala Met Tyr Leu Val Ala Leu Ala Gly Asn Ala Ala Leu 35 40 45 Ile Leu Val Ile Val Thr Asp Ser Ala Leu His Ala Pro Met Tyr Leu 50 55 60 Phe Leu Cys Leu Leu Ser Phe Thr Asp Leu Ala Leu Ser Ser Thr Thr 65 70 75 80 Val Pro Lys Met Leu Ala Ile Leu Trp Leu His Ala Gly Glu Ile Ser 85 90 95 Phe Gly Gly Cys Leu Ala Gln Met Phe Cys Val His Ser Ile Tyr Ala 100 105 110 Leu Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 Ile Cys Asn Pro Leu Arg Tyr Thr Thr Ile Leu Asn His Thr Val Ile 130 135 140 Gly Lys Ile Gly Leu Val Gly Leu Leu Arg Ser Val Ala Ile Val Ser 145 150 155 160 Pro Phe Ile Phe Leu Leu Arg Arg Leu Pro Tyr Cys Asp His His Val 165 170 175 Met Ala His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys 180 185 190 Gly Asn Ile Thr Val Asn Ile Val Tyr Gly Leu Thr Val Ala Leu Leu 195 200 205 Ala Met Gly Leu Asp Ser Ile Leu Ile Ala Ile Ser Tyr Gly Phe Ile 210 215 220

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Leu 225 His Ala Val Phe Arg 230 Leu 069269_0225_SL.TXT Pro Ser Gln Asp Ala Arg 235 His Lys Ala 240 Leu Ser Thr Cys Gly Ser His Leu Gly Val Ile Leu Val Phe Tyr Ile 245 250 255 Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly Gln His Arg Val 260 265 270 Pro Lys Asn Val His Ile Phe Leu Ala Asn Leu Tyr Val Leu Val Pro 275 280 285 Pro Val Leu Asn Pro Ile Ile Tyr Gly Ala Arg Thr Lys Glu Ile Gln 290 295 300 Ser Arg Leu Leu Arg Phe Leu His Leu Gly Lys Ile Leu Met 305 310 315

<210> 1107 <211> 957 <212> DNA <213> Canis familiaris <400> 1107

atgtcaacct ctaacctcag tgatgacagt cttccagcca tcatgttcct gacgggaatc 60 ccagggctgg agtgggctca tgcctggatt gccatcccct tctgtgccat gtatctggta 120 gcactggctg ggaatgctgc cctcatcctg gtcattgtga cagacagtgc tcttcatgca 180 cccatgtacc tcttcctgtg ccttctctca ctcactgact tggctctcag ctccaccacc 240 gtgccgaaga cattagcaat tttgtggctc catgctggag aaatttcctt tggtggatgc 300 ctggcccaga tgttttgtgt ccattctatc tatgctctgg agtcctcagt tcttctggcc 360 atggcctttg atcgctatgt ggctatttgc aacccactga gatatatgat catcctcaac 420 cgtagcatca taggcagaat tggccttact ggcatactcc gtagtatcgc tgttgtctcc 480 ccgttcattt tcttgctgag gcgactgcct tactgtggtc accatgtcat ggcacataca 540 tattgtgagc acatgggcat tgctcgcctg gcctgtggca acatcactgt caatattgtc 600 tatgggctga ctgtggccct gctagctgtg ggtctggatt ccatcctcat tgccatttcc 660

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069269_0225_SL.TXT tatggcttta tcctccacgc tgtcttccgc cttccatctc aagatgccag gcacaaggct ctgagtacct gtggctccca cctcggggtc atcctggtct tctacattcc tgccttcttc tccttcctca cccatcgttt tggccagcac cgagttccca agaatgtgca catctttctg gcgaacctct atgtgctggt gcctcctgtg ctcaatccaa tcatctatgg ggctaggacc aaggagattc ggagtcggct tctgagactg cttcacttgg ggaaggtctc agtgtga

720

780

840

900

957 <210> 1108 <211> 318 <212> PRT <213> Canis familiaris <400> 1108

Met Ser 1 Thr Ser Asn Leu Ser Asp Asp Ser Leu Pro Ala Ile Met 15 Phe 5 10 Leu Thr Gly Ile Pro Gly Leu Glu Trp Ala His Ala Trp Ile Ala Ile 20 25 30 Pro Phe Cys Ala Met Tyr Leu Val Ala Leu Ala Gly Asn Ala Ala Leu 35 40 45 Ile Leu Val Ile Val Thr Asp Ser Ala Leu His Ala Pro Met Tyr Leu 50 55 60 Phe Leu Cys Leu Leu Ser Leu Thr Asp Leu Ala Leu Ser Ser Thr Thr 65 70 75 80 Val Pro Lys Thr Leu Ala Ile Leu Trp Leu His Ala Gly Glu Ile Ser 85 90 95 Phe Gly Gly Cys Leu Ala Gln Met Phe Cys Val His Ser Ile Tyr Ala 100 105 110 Leu Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 Ile Cys Asn Pro Leu Arg Tyr Met Ile Ile Leu Asn Arg Ser Ile Ile 130 135 140

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Gly 145 Arg Ile Gly Leu Thr Gly Ile Leu Arg Ser Ile Ala Val Val Ser 150 155 160 Pro Phe Ile Phe Leu Leu Arg Arg Leu Pro Tyr Cys Gly His His Val 165 170 175 Met Ala His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys 180 185 190 Gly Asn Ile Thr Val Asn Ile Val Tyr Gly Leu Thr Val Ala Leu Leu 195 200 205 Ala Val Gly Leu Asp Ser Ile Leu Ile Ala Ile Ser Tyr Gly Phe Ile 210 215 220 Leu His Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg His Lys Ala 225 230 235 240 Leu Ser Thr Cys Gly Ser His Leu Gly Val Ile Leu Val Phe Tyr Ile 245 250 255 Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly Gln His Arg Val 260 265 270 Pro Lys Asn Val His Ile Phe Leu Ala Asn Leu Tyr Val Leu Val Pro 275 280 285 Pro Val Leu Asn Pro Ile Ile Tyr Gly Ala Arg Thr Lys Glu Ile Arg 290 295 300 Ser Arg Leu Leu Arg Leu Leu His Leu Gly Lys Val Ser Val

305 310 315 <210> 1109 <211> 948 <212> DNA <213> Canis familiaris <400> 1109 atgggtgcct tcggaatcaa tgcctctgat gctcccacct ttatactgac aggcttccca

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ggaatggagt ccatggaatc ctggctatcc ttccctctct ttctattcta tgctgtctcc 120 attgtgggaa acactttgat cctcctcatt gttaaggagg agcagagctt gcaccagccc 180 atgtattact tcttgtctct cctttcaatc aatgacttgg gagtgtcctt ttccacattg 240 ccaactgtgc tggctgccct ttgcttccat gcccgggtga tttcctttaa tgcctgctta 300 gcccaaatgt ttttcatcca tctcttctct tggacagagt ctggaatcct tctggctatg 360 agcttcgatc gctatgtggc catctgcaac cccctgcgct atgctacagt gctcactaat 420 gcctgcattg tggcaatggg cctgtgtatt gtcctccgaa gctttgccct catccttgtc 480 ttcccactgc tgctgcacag actgcccttc tgtcaccccc agaatatcct ctcccatgcc 540 tactgccttc acgtggatat gattaagctg gcatgtactg atgtctccct caatagccac 600 tatggacttt ccattgtgct attcaccttt ggcctggact ctgcactcat attcatctct 660 tatgtactaa tcttacgatc agtgattgcc attgcttccc gagaggagct tatcaagaca 720 ctgaacacat gtgtgtccca catcctagct gtgctcatct tctatgtact catggtgtgt 780 gtgtccattg ttcatcgctt tggtgctggt ctgcctcatg ctgtccatat cctcatgtca 840 attctctacc tctttgtgcc tcccatgctc aatcctatta tctattccat caagacaaag 900 gagatacgtc gcaggctctt caagatgctc tttaggctta agtcctga 948

<210> 1110 <211> 315 <212> PRT <213> Canis familiaris

<400> 1110 Ile Asn Ala Ser Asp Ala Pro Thr Phe Ile Leu Met 1 Gly Ala Phe Gly 5 10 15 Thr Gly Phe Pro Gly Met Glu Ser Met Glu Ser Trp Leu Ser Phe Pro 20 25 30 Leu Phe Leu Phe Tyr Ala Val Ser Ile Val Gly Asn Thr Leu Ile Leu 35 40 45 Leu Ile Val Lys Glu Glu Gln Ser Leu His Gln Pro Met Tyr Tyr Phe 50 55 60

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Leu 65 Ser Leu Leu Ser Ile Asn Asp Leu Gly Val Ser Phe Ser Thr Leu 70 75 80 Pro Thr Val Leu Ala Ala Leu Cys Phe His Ala Arg Val Ile Ser Phe 85 90 95 Asn Ala Cys Leu Ala Gln Met Phe Phe Ile His Leu Phe Ser Trp Thr 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ala Thr Val Leu Thr Asn Ala Cys Ile Val 130 135 140 Ala Met Gly Leu Cys Ile Val Leu Arg Ser Phe Ala Leu Ile Leu Val 145 150 155 160 Phe Pro Leu Leu Leu His Arg Leu Pro Phe Cys His Pro Gln Asn Ile 165 170 175 Leu Ser His Ala Tyr Cys Leu His Val Asp Met Ile Lys Leu Ala Cys 180 185 190 Thr Asp Val Ser Leu Asn Ser His Tyr Gly Leu Ser Ile Val Leu Phe 195 200 205 Thr Phe Gly Leu Asp Ser Ala Leu Ile Phe Ile Ser Tyr Val Leu Ile 210 215 220 Leu Arg Ser Val Ile Ala Ile Ala Ser Arg Glu Glu Leu Ile Lys Thr 225 230 235 240 Leu Asn Thr Cys Val Ser His Ile Leu Ala Val Leu Ile Phe Tyr Val 245 250 255 Leu Met Val Cys Val Ser Ile Val His Arg Phe Gly Ala Gly Leu Pro 260 265 270

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His Ala Val His Ile Leu Met Ser Ile Leu Tyr Leu Phe Val Pro Pro 275 280 285 Met Leu Asn Pro Ile Ile Tyr Ser Ile Lys Thr Lys Glu Ile Arg Arg 290 295 300 Arg Leu Phe Lys Met Leu Phe Arg Leu Lys Ser 305 310 315

<210> 1111 <211> 906 <212> DNA <213> Canis familiaris <400> 1111 aacagctcag acttgcctcc tttcaccctg tcagggttcc cagggctgga gacttcccaa 60 cattggatgt ttctgctctt tggtatcctc tacattgtct ccattgtggg caatgccctt 120 atccttttca tcatcaagga ggtacagagt ttgcataagc ctatgtacta cttcctatcc 180 ctgctgtcag ttaatgacct aggtgtgtcc ttttccacac tgcccaccgt gttggccaca 240 ttttgcttaa gagagatcgg ctttgattct tacatggctc aaatgttttt tatccacctc 300 ttctccttta tggagtctgg agttctcctg gttatgagtt ttgaccgcta tgtggccatc 360 tgtaacccct tgcgctatgc cacagtgctc actgatgcac ctgtggtggt gcgcctgggc 420 atagctgttg tcatccgtgg tttctgtatg gttttcccac tgcccttcct tctgaagagg 480 ttgtccttct gcaaggccaa tgtactctct catccttact gcctgcatcc agatctgatc 540 cgcttgccct gtggtgacat taccatcaat aatatttttg gtcaattcat tgtcatctct 600 aactttggtc tggattctgc tctcattctc ctctcctaca tgctcatcct gcgctctgta 660 cttgctattg cctcccggga ggaaagactt aagaccctca atacgtgtgt gtcacacatg 720 tgtgctgtgc ttatgttctt tgtgcctatg gtcggtgtgt ccatggccgc tcgctatggg 780 aggcatgccc cacagtatgt acatacactc atgtccctca tctacctttt tgtacctcct 840 atgctcaacc cagtcatcta ttccatcaaa accaaagaga tccgtcaaag gctttgcaaa 900 atacta 906

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069269_0225_SL.TXT <210> 1112 <211> 302 <212> PRT <213> Canis familiaris

<400> 1112 Gly Phe Pro Gly 15 Leu Asn 1 Ser Ser Asp Leu Pro 5 Pro Phe Thr Leu 10 Ser Glu Thr Ser Gln His Trp Met Phe Leu Leu Phe Gly Ile Leu Tyr Ile 20 25 30 Val Ser Ile Val Gly Asn Ala Leu Ile Leu Phe Ile Ile Lys Glu Val 35 40 45 Gln Ser Leu His Lys Pro Met Tyr Tyr Phe Leu Ser Leu Leu Ser Val 50 55 60 Asn Asp Leu Gly Val Ser Phe Ser Thr Leu Pro Thr Val Leu Ala Thr 65 70 75 80 Phe Cys Leu Arg Glu Ile Gly Phe Asp Ser Tyr Met Ala Gln Met Phe 85 90 95 Phe Ile His Leu Phe Ser Phe Met Glu Ser Gly Val Leu Leu Val Met 100 105 110 Ser Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Ala Thr 115 120 125 Val Leu Thr Asp Ala Pro Val Val Val Arg Leu Gly Ile Ala Val Val 130 135 140 Ile Arg Gly Phe Cys Met Val Phe Pro Leu Pro Phe Leu Leu Lys Arg 145 150 155 160 Leu Ser Phe Cys Lys Ala Asn Val Leu Ser His Pro Tyr Cys Leu His 165 170 175 Pro Asp Leu Ile Arg Leu Pro Cys Gly Asp Ile Thr Ile Asn Asn Ile

Page 1250

180

069269_0225_SL.TXT 185 190

Phe Gly Gln Phe Ile Val 195 Ile Ser Asn Phe Gly Leu Asp Ser Ala Leu 200 205 Ile Leu Leu Ser Tyr Met Leu Ile Leu Arg Ser Val Leu Ala Ile Ala 210 215 220 Ser Arg Glu Glu Arg Leu Lys Thr Leu Asn Thr Cys Val Ser His Met 225 230 235 240 Cys Ala Val Leu Met Phe Phe Val Pro Met Val Gly Val Ser Met Ala 245 250 255 Ala Arg Tyr Gly Arg His Ala Pro Gln Tyr Val His Thr Leu Met Ser 260 265 270 Leu Ile Tyr Leu Phe Val Pro Pro Met Leu Asn Pro Val Ile Tyr Ser 275 280 285 Ile Lys Thr Lys Glu Ile Arg Gln Arg Leu Cys Lys Ile Leu 290 295 300

<210> 1113 <211> 945 <212> DNA <213> Canis familiaris <400> 1113

atgggaagtt ttgggactaa catctctagc actaccagct tctcactaac aggcttccca 60 gagatggagg gtctacaaca ctcgttagct gccctcctct tgctgcttta tgctatttcc 120 atcctgggca atatcctaat cctcgtcatt ataaaggagg agcagagctt gcaccagcct 180 atgtactact tcttgtctct gttgtctgtc aatgacctgg gtgtgtcctt ttctacattg 240 cccactgtat tggctgcctt gtgctttcat gctccagaga ttgcctttga tgcctgcctg 300 acccagatgt tcttcatcca ctttttctcc tggacagaat ctgggatcct gctggccatg 360 agttttgatc gctatgtggc catctgtaac cctctgcgtt attcttcggt gctcactgat 420 atccgtgtgg ctcacatggg catatccatc atcatccgca gcttctgcat ggttttccca 480

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ttgcctttcc ttctgaagag gctgcctttc tgtaaagcca atgtgttaac acattcctac 540 tgtttgcacc cagacttgat ccgcctgcct tgtggagata ccaccatcaa cagcatgtat 600 ggcctgttca ttgttatctc tgcctttggt gtagactcag tgctcattct cctctcctac 660 gtgcttatac tgcactccat attggccatt gcctcccagg aggagaggct taagacactc 720 aacacatgtg tgtcacacat atgtgctgtg ctcatcttct atgtacccat ggttagtgtg 780 tccatggttc atcgatttgg gaagcatgcc cctgagtaca tgcacaagtt catgtccctg 840 gtatatctct ttgtgcctcc aatgctcaac ccaattatct attccattaa aactaaagaa 900 attcgtaaga ggctgtacaa aatgtttttg aagcctaata tttga 945

<210> 1114 <211> 314 <212> PRT <213> Canis familiaris <400> 1114

Met Gly Ser Phe Gly Thr Asn Ile Ser Ser Thr Thr Ser Phe Ser Leu 1 5 10 15 Thr Gly Phe Pro Glu Met Glu Gly Leu Gln His Ser Leu Ala Ala Leu 20 25 30 Leu Leu Leu Leu Tyr Ala Ile Ser Ile Leu Gly Asn Ile Leu Ile Leu 35 40 45 Val Ile Ile Lys Glu Glu Gln Ser Leu His Gln Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Leu Leu Ser Val Asn Asp Leu Gly Val Ser Phe Ser Thr Leu 65 70 75 80 Pro Thr Val Leu Ala Ala Leu Cys Phe His Ala Pro Glu Ile Ala Phe 85 90 95 Asp Ala Cys Leu Thr Gln Met Phe Phe Ile His Phe Phe Ser Trp Thr 100 105 110

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Glu Ser Gly 115 Ile Leu Leu Ala 069269_0225_SL.TXT Met Ser Phe Asp Arg Tyr 120 125 Val Ala Ile Cys Asn Pro Leu Arg Tyr Ser Ser Val Leu Thr Asp Ile Arg Val Ala 130 135 140 His Met Gly Ile Ser Ile Ile Ile Arg Ser Phe Cys Met Val Phe Pro 145 150 155 160 Leu Pro Phe Leu Leu Lys Arg Leu Pro Phe Cys Lys Ala Asn Val Leu 165 170 175 Thr His Ser Tyr Cys Leu His Pro Asp Leu Ile Arg Leu Pro Cys Gly 180 185 190 Asp Thr Thr Ile Asn Ser Met Tyr Gly Leu Phe Ile Val Ile Ser Ala 195 200 205 Phe Gly Val Asp Ser Val Leu Ile Leu Leu Ser Tyr Val Leu Ile Leu 210 215 220 His Ser Ile Leu Ala Ile Ala Ser Gln Glu Glu Arg Leu Lys Thr Leu 225 230 235 240 Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Ile Phe Tyr Val Pro 245 250 255 Met Val Ser Val Ser Met Val His Arg Phe Gly Lys His Ala Pro Glu 260 265 270 Tyr Met His Lys Phe Met Ser Leu Val Tyr Leu Phe Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Ser Ile Lys Thr Lys Glu Ile Arg Lys Arg 290 295 300 Leu Tyr Lys Met Phe Leu Lys Pro Asn Ile 305 310

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069269_0225_SL.TXT <210> 1115 <211> 939 <212> DNA <213> Canis familiaris <400> 1115 atgggactgt tcaatgtcag tcatcctgct tccttcctcc tgactggcat ccctggtctg 60 gagagctctc actcctggct agcagggccc ctctgtgtga tgtatgccgt ggccctcgga 120 ggcaacactg tgatcctaca ggccgtgcga gtggagccca gtctccacga gcccatgtac 180 tacttcctgt ccatgctgtc cttcagtgac gtggccatgt ccatggccac cctgcccacc 240 gtgctcagaa ccttctgcct caacgcccgc agcattgctt ttgatgcctg tctgatccag 300 atgtttctca ttcattcctt ctccatgatg gagtcaggga ttctgctggc catgagcttt 360 gaccgctatg tggccatttg tgatcctttg cactatgcca ctgtgctcac caatggagtc 420 attgctggaa tcggcgtagc tgtgactgcc cggagcttca tcaccctctt tccccttccc 480 ttcctcttca agaggctgcc tgtctgcaga tccaatgttc tttctcactc ctattgcctg 540 cacccagaca tgatgaagct agcctgtgct gatatcacta tcaacagcat ctatggactc 600 tttgttcttg tatccacctt tggcatggac atgtttttta ttttcctctc ctatgtgctc 660 attctgcgtt cagtcatggc catcgcttcc cgcaaggaac gcctgaaagc tctcaacaca 720 tgtgtgtcac atatcttggt tgtattagca ttttatgtac caatgattgg ggtttctgta 780 gtccaccgct ttgggaagca tgccccacgc tacatacatg tcctcatgtc taatgtttac 840 ctctttgtac ctcctgtgct caaccctctg atttatagtg ccaagacaaa ggagatccgc 900 cgagccattg tccgtatgtt tcgccccatc agaatgtga 939 <210> 1116 <211> 312 <212> PRT <213> Canis familiaris <400> 1116

Met Gly Leu Phe Asn Val Ser His Pro Ala Ser Phe Leu Leu Thr Gly 1 5 10 15

Ile Pro Gly Leu Glu Ser Ser His Ser Trp Leu Ala Gly Pro Leu Cys 20 25 30

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Val Met Tyr 35 Ala Val Ala Leu Gly Gly Asn Thr Val Ile Leu Gln Ala 40 45 Val Arg Val Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Met Leu Ser Phe Ser Asp Val Ala Met Ser Met Ala Thr Leu Pro Thr 65 70 75 80 Val Leu Arg Thr Phe Cys Leu Asn Ala Arg Ser Ile Ala Phe Asp Ala 85 90 95 Cys Leu Ile Gln Met Phe Leu Ile His Ser Phe Ser Met Met Glu Ser 100 105 110 Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asp 115 120 125 Pro Leu His Tyr Ala Thr Val Leu Thr Asn Gly Val Ile Ala Gly Ile 130 135 140 Gly Val Ala Val Thr Ala Arg Ser Phe Ile Thr Leu Phe Pro Leu Pro 145 150 155 160 Phe Leu Phe Lys Arg Leu Pro Val Cys Arg Ser Asn Val Leu Ser His 165 170 175 Ser Tyr Cys Leu His Pro Asp Met Met Lys Leu Ala Cys Ala Asp Ile 180 185 190 Thr Ile Asn Ser Ile Tyr Gly Leu Phe Val Leu Val Ser Thr Phe Gly 195 200 205 Met Asp Met Phe Phe Ile Phe Leu Ser Tyr Val Leu Ile Leu Arg Ser 210 215 220 Val Met Ala Ile Ala Ser Arg Lys Glu Arg Leu Lys Ala Leu Asn Thr 225 230 235 240

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Cys Val Ser His Ile 245 Leu Gly Val Ser Val 260 Val His His Val Leu 275 Met Ser Asn Pro Leu 290 Ile Tyr Ser Ala Arg 305 Met Phe Arg Pro Ile 310

Val Val Leu Ala 250 Phe Arg Phe Gly 265 Lys His Val Tyr 280 Leu Phe Val Lys 295 Thr Lys Glu Ile Arg Met

Tyr Val Pro Met 255 Ile Ala Pro Arg 270 Tyr Ile Pro Pro 285 Val Leu Asn Arg Arg Ala Ile Val

300 <210> 1117 <211> 948 <212> DNA <213> Canis familiaris <400> 1117 atgtacaacc tgagtagcta gagcagtacc acgtctggat ggcaacagta tccttctcta tttttccttt ccatgctagc acccttacca tcttctggct ttattctttc tgcattatag gaccgctatg tggccatctg actgtcaaaa ttgttgtggg ttccttgcaa atcgtctacc cacataggtg tggcccgact tgtgttccca tcatgacagt atcctctgtg tagtcttccg tgtggttccc atgtctgtgt caacacaggt gacttcaccc cagcatcccc ttctgcttta cctcattgct gtggagcgga cattacagat gtgatcttgt tggtccccag aaaatcagtt ctttgtcctg gactcagcta ctcccctctg agatacacca aatttccttc agaagtttct tttctgcggg acacgcatca tgcctgtgct gacatctcca catctcagat gtgattctca cctcccctcc ctagatgccc catcctcatg ttctatatac

Page 1256 tcctgggcat ccctggtctt tctatcttgt ggccattgtg gtcttcacgc acccatgttc ctaccacatg tgtccccaaa ttcctggttg tctcacccag tactcctggc catggcattt ctattctgaa ccccaggacc gtgttatagt tccatgtgtt taccacacac atactgtgag tcaacatctg gtatggcttt ttgccgtttc ttacaccctc gtcagaaggc ccttggcacc cagcattctt ctccatcctt

120

180

240

300

360

420

480

540

600

660

720

780

069269_0225_SL.TXT gcccatcgct ttgggcataa tgtcccccgt acttttcaca tcctctttgc taacctctat gtagttatgc cacctgcact caatcctatt gtctatggag taaagaccaa gcagatccgg gacaaagtta ttctcctgct ctttccccag aaggttgcag tgatatag

840

900

948 <210> 1118 <211> 315 <212> PRT <213> Canis familiaris

<400> 1118 Ser Tyr Asn Thr Gly Asp Phe Thr Leu Leu Gly Met Tyr 1 Asn Leu Ser 5 10 15 Ile Pro Gly Leu Glu Gln Tyr His Val Trp Ile Ser Ile Pro Phe Cys 20 25 30 Phe Ile Tyr Leu Val Ala Ile Val Gly Asn Ser Ile Leu Leu Tyr Leu 35 40 45 Ile Ala Val Glu Arg Ser Leu His Ala Pro Met Phe Phe Phe Leu Ser 50 55 60 Met Leu Ala Ile Thr Asp Val Ile Leu Ser Thr Thr Cys Val Pro Lys 65 70 75 80 Thr Leu Thr Ile Phe Trp Leu Gly Pro Gln Lys Ile Ser Phe Pro Gly 85 90 95 Cys Leu Thr Gln Leu Phe Phe Leu His Tyr Ser Phe Val Leu Asp Ser 100 105 110 Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Arg Tyr Thr Thr Ile Leu Asn Pro Arg Thr Thr Val Lys Ile 130 135 140 Val Val Gly Ile Ser Phe Arg Ser Phe Cys Val Ile Val Pro Cys Val 145 150 155 160

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Phe Leu Ala Asn Arg Leu Pro Phe Cys Gly Thr Arg Ile Ile Pro His 165 170 175 Thr Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Ile Trp Tyr Gly Phe Cys Val Pro Ile Met Thr Val Ile 195 200 205 Ser Asp Val Ile Leu Ile Ala Val Ser Tyr Thr Leu Ile Leu Cys Val 210 215 220 Val Phe Arg Leu Pro Ser Leu Asp Ala Arg Gln Lys Ala Leu Gly Thr 225 230 235 240 Cys Gly Ser His Val Cys Val Ile Leu Met Phe Tyr Ile Pro Ala Phe 245 250 255 Phe Ser Ile Leu Ala His Arg Phe Gly His Asn Val Pro Arg Thr Phe 260 265 270 His Ile Leu Phe Ala Asn Leu Tyr Val Val Met Pro Pro Ala Leu Asn 275 280 285 Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp Lys Val Ile 290 295 300 Leu Leu Leu Phe Pro Gln Lys Val Ala Val Ile 305 310 315

<210> 1119 <211> 942 <212> DNA <213> Canis familiaris <400> 1119 atgtacaacc tgagtagcta caacacaggt gacttcaccc tcttgggcat ccctggcctt gagcagtacc acgtctggat cagcatcccc ttctgcttta tctatctcat ggccattgtg

120

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ggcaacagta tccttctcta cctcattgcc atggagcgga gtcttcacac acccatgttc 180 tttttccttt ccatgctagc cattacagat gtgatcttgt ctaccacatg tgtccccaaa 240 acccttaccg tcttctggct tggtccccag aaaatcagtt ttcctggttg cctcacccag 300 ttattctttc tgcacagtag ctttgtcctg gactcagcta tactcctggc catggcattt 360 gaccgctatg tggccatctg ctcccctctg agatacacca ctattctgac ccccaggacc 420 atcaccaaga ttgcagtggg catctcctgt cgaagcttct gcatcatcct gccagttata 480 ttcttgctta cacgcttgcc tttctgcagg acacgcatca taccacacac atactgtgag 540 cacataggtg tggcccggct cgcctgtgct gacatctcca tcaacatctg gtatggcttt 600 tgtgttccca tcatgacagt catctcagat gtgattctca ttgccgtttc ttacaccctc 660 atcctctgtg cggtcttccg cttgccctcc cgagatgccc gccagaaggc ccttggcaca 720 tgtggttccc atgtctgtgt catcctcatg ttttatacac ctgccttttt ctccatcctt 780 gctcatcgtt ttggacacaa tgtctcccgc actttccaca tcatgtttgc caacctctac 840 attgttattc cacctgcact caaccccatt gtctatggag tgaagaccaa gcagatcaga 900 gataaggtca tccttttgtt ttctaccaag ggttcagaat ga 942

<210> 1120 <211> 313 <212> PRT

<213> Canis familiaris <400> 1120 Met Tyr Asn Leu Ser Ser Tyr Asn Thr Gly Asp Phe Thr Leu Leu Gly 1 5 10 15 Ile Pro Gly Leu Glu Gln Tyr His Val Trp Ile Ser Ile Pro Phe Cys 20 25 30 Phe Ile Tyr Leu Met Ala Ile Val Gly Asn Ser Ile Leu Leu Tyr Leu 35 40 45 Ile Ala Met Glu Arg Ser Leu His Thr Pro Met Phe Phe Phe Leu Ser 50 55 60 Met Leu Ala Ile Thr Asp Val Ile Leu Ser Thr Thr Cys Val Pro Lys

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Thr Leu Thr Val Phe Trp Leu Gly Pro Gln Lys Ile Ser Phe Pro Gly 85 90 95 Cys Leu Thr Gln Leu Phe Phe Leu His Ser Ser Phe Val Leu Asp Ser 100 105 110 Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro Arg Thr Ile Thr Lys Ile 130 135 140 Ala Val Gly Ile Ser Cys Arg Ser Phe Cys Ile Ile Leu Pro Val Ile 145 150 155 160 Phe Leu Leu Thr Arg Leu Pro Phe Cys Arg Thr Arg Ile Ile Pro His 165 170 175 Thr Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Ile Trp Tyr Gly Phe Cys Val Pro Ile Met Thr Val Ile 195 200 205 Ser Asp Val Ile Leu Ile Ala Val Ser Tyr Thr Leu Ile Leu Cys Ala 210 215 220 Val Phe Arg Leu Pro Ser Arg Asp Ala Arg Gln Lys Ala Leu Gly Thr 225 230 235 240 Cys Gly Ser His Val Cys Val Ile Leu Met Phe Tyr Thr Pro Ala Phe 245 250 255 Phe Ser Ile Leu Ala His Arg Phe Gly His Asn Val Ser Arg Thr Phe 260 265 270 His Ile Met Phe Ala Asn Leu Tyr Ile Val Ile Pro Pro Ala Leu Asn

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275 280 285 Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp Lys Val Ile 290 295 300 Leu Leu Phe Ser Thr Lys Gly Ser Glu 305 310

<210> 1121 <211> 888 <212> DNA <213> Canis familiaris <400> 1121 cacatgtgga tctccatccc tttctgtctg atgtacccag tggctgtgtc aggaaatgtt 60 atcctaatca gcatcgtggc agtggaacac agtcttcatg aacccatgta cctcttcctc 120 tccatgttgg ctttttggga tctgatgcta tccacattca tagtacccaa agccctgagc 180 atcttctggt ttgatgatat ggacatctct tttggggttg tgtaacccaa ctcttttttt 240 ttttttaatg aattttgcct ttttagtgaa gtcaggcatt ctcttagcct ctgcttttga 300 ttgctatgaa cccttctgct ctgcatagca gtggtcatct gctacccact gagatatacc 360 accattctct gccatggtgt cattggtaaa atgggggtgc tgtagtgctg aggaattttg 420 caactgtttt ccccattatc ttcctagtgg ggaaagataa tagaggtgtc tgcccctctt 480 tttacaaaca tcattgccca cacattctgt gaacacatga ggctggtaaa gttggcttgt 540 gctgttatca tcatcaacat ctggcatgga atctctgtgt cattactcac tattatgcta 600 gatatggtga caatagtcat ctcctatgag ctcattcttg aggcagtctt cagactgcca 660 ttccatgatg gacaaattaa agccctcagc atgtgtggtt ctcacgtctg tgtcatcctc 720 atgttctgcc ttccaggggt tttcactgtt attgctcagc gcttcagctg aaaaatcccc 780 aaccatggcc acatcctgtt ggtcaatctc tatgatgtcc ccataacaat cccaattatc 840 tatggagtaa agaccaaaca tattcatgac tgagtggcct tgctattt 888 <210> 1122 <211> 74 <212> PRT <213> Canis familiaris

Page 1261

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<400> 1122 His Met Trp Ile Ser Ile Pro Phe Cys Leu Met Tyr Pro Val Ala Val 1 5 10 15 Ser Gly Asn Val Ile Leu Ile Ser Ile Val Ala Val Glu His Ser Leu 20 25 30 His Glu Pro Met Tyr Leu Phe Leu Ser Met Leu Ala Phe Trp Asp Leu 35 40 45 Met Leu Ser Thr Phe Ile Val Pro Lys Ala Leu Ser Ile Phe Trp Phe 50 55 60 Asp Asp Met Asp Ile Ser Phe Gly Val Val 65 70

<210> 1123 <211> 957 <212> DNA <213> Canis familiaris <400> 1123

atggttcctg tcatggccac tccaaatgga actctggtcc acccagcata tttcctgctg 60 gtgggcattc ctggcctggg gcctaacata cacttttggc tagcttttcc actgtgtttt 120 atgtatgcct tggccaccct ggggaacctg gccattgtcc ttatcatccg tgtggaaagg 180 cgcctgcatg agcccatgta cctcttcctg gccatgcttt ctaccattga cctagtcctg 240 tcttctgtca ctatgcccaa gatggccagc ctcttcctga ctggcatcca ggagatagga 300 ttcaatgttt gtctggctca gatgttcctt atccatgctc tgtcagccat ggagtcagct 360 gtcctgctgg ccatggcttt tgaccgcttt gtggccatct gccatccact gcggcatgct 420 tctgtgctca cagggcctac tgtggccaag attggactag ctgcccttac caggggattt 480 gttttcttct tcccactgcc cttcatcctg aagcggttgt catattgcca aacacatact 540 gtcacacact ccttctgttt gcaccaagat attatgaagt tgtcctgtac tgataccatg 600 gttaatgtag tatatggact cttcattatc ctctcagtga tgggtgtgga ctccctcttc 660 attggcctct cctacatcct catactgaag actgtattgg atctgtcttc tcggggcgca 720

Page 1262

069269_0225_SL.TXT gcactcaagg cttttaacac atgcgtctcc catctctgtg ctgtcctggt cttctatgtg cccctcattg ggctctcagt ggtgcacagg ctggggggtc ctacctccat gctccatgtg gttatggcta atatctatct tctgctacca cctgtggtca atcctgttgt ctatggagcc aagaccaagg agatccgttc acgggtcctc catatcttct cacagggtgg taggtga

780

840

900

957 <210> 1124 <211> 318 <212> PRT <213> Canis familiaris <400> 1124

Met Val Pro Val Met Ala Thr Pro Asn Gly Thr Leu Val His Pro Ala 1 5 10 15 Tyr Phe Leu Leu Val Gly Ile Pro Gly Leu Gly Pro Asn Ile His Phe 20 25 30 Trp Leu Ala Phe Pro Leu Cys Phe Met Tyr Ala Leu Ala Thr Leu Gly 35 40 45 Asn Leu Ala Ile Val Leu Ile Ile Arg Val Glu Arg Arg Leu His Glu 50 55 60 Pro Met Tyr Leu Phe Leu Ala Met Leu Ser Thr Ile Asp Leu Val Leu 65 70 75 80 Ser Ser Val Thr Met Pro Lys Met Ala Ser Leu Phe Leu Thr Gly Ile 85 90 95 Gln Glu Ile Gly Phe Asn Val Cys Leu Ala Gln Met Phe Leu Ile His 100 105 110 Ala Leu Ser Ala Met Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp 115 120 125 Arg Phe Val Ala Ile Cys His Pro Leu Arg His Ala Ser Val Leu Thr 130 135 140 Gly Pro Thr Val Ala Lys Ile Gly Leu Ala Ala Leu Thr Arg Gly Phe

Page 1263

0 6926 9_02 25_S L.TX T 145 150 155 160 Val Phe Phe Phe Pro Leu Pro Phe Ile Leu Lys Arg Leu Ser Tyr Cys 165 170 175 Gln Thr His Thr Val Thr His Ser Phe Cys Leu His Gln Asp Ile Met 180 185 190 Lys Leu Ser Cys Thr Asp Thr Met Val Asn Val Val Tyr Gly Leu Phe 195 200 205 Ile Ile Leu Ser Val Met Gly Val Asp Ser Leu Phe Ile Gly Leu Ser 210 215 220 Tyr Ile Leu Ile Leu Lys Thr Val Leu Asp Leu Ser Ser Arg Gly Ala 225 230 235 240 Ala Leu Lys Ala Phe Asn Thr Cys Val Ser His Leu Cys Ala Val Leu 245 250 255 Val Phe Tyr Val Pro Leu Ile Gly Leu Ser Val Val His Arg Leu Gly 260 265 270 Gly Pro Thr Ser Met Leu His Val Val Met Ala Asn Ile Tyr Leu Leu 275 280 285 Leu Pro Pro Val Val Asn Pro Val Val Tyr Gly Ala Lys Thr Lys Glu 290 295 300 Ile Arg Ser Arg Val Leu His Ile Phe Ser Gln Gly Gly Arg 305 310 315

<210> 1125 <211> 951 <212> DNA <213> Canis familiaris <400> 1125 atgatgtcca cattgaattt aacaagtgtc aatccaagtg tcttcatgtt ggtggggatc ccaggactgg agcaattcca catctggatt ggaattcctt tcttcgttat ctacctggtg

120

Page 1264

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gcccttgtag gtaatggcat ccttctttac ctcatcacta tggaccacaa cctccatgag 180 cccatgttct tctttctctc catgttggcc tctgcagacc tcatattatg caccacgtgt 240 atgcccaaaa cacttggcat attctggttg aaatctcaga aaatcacttt tcctggctgc 300 cttacccagt tgttctttct tcacttcagc ttttttctgg attcagccat tttgttgggc 360 atggcgtttg atcgttacat ggccatttgc tctcctttga gatacagaag tgttttgaca 420 cctaggacaa tagtcaagat catggtgggc attgtgggtc ggagctttag tgtcattctg 480 cctgttgttt tcctggtgaa acgtttgccc ttctgcagga cgcgaatcat tcctcacaca 540 tactgtgaac atataggtgt ggctcggctc gcctgcgcgg acatctccat caacatctgg 600 tatggctttg ctgtgcctgt aatgactatt atctcagacc tgatcctcat tggtatttcc 660 tattctctca tccttcatgc tgttttccac cttccatcca gagatgcccg gcagaaagcc 720 ctcagcacct gtggttctca tgtcagtgtc attctcatat tctacacacc agccatgttc 780 tctgtcctta ctcatcgctt tggccacaat atctctctca cctttcacat catgtttgcc 840 aacctctatg tggcaatacc tcctgcactc aatcctatca tttacggtgt aaaaaccaag 900 cagatcaggg acaagatcat ccttctattc tttcctaaag ggatgcagtg a 951

<210> 1126 <211> 316 <212> PRT <213> Canis familiaris <400> 1126

Met Met Ser Thr Leu Asn Leu Thr Ser Val Asn Pro Ser Val Phe Met 1 5 10 15 Leu Val Gly Ile Pro Gly Leu Glu Gln Phe His Ile Trp Ile Gly Ile 20 25 30 Pro Phe Phe Val Ile Tyr Leu Val Ala Leu Val Gly Asn Gly Ile Leu 35 40 45 Leu Tyr Leu Ile Thr Met Asp His Asn Leu His Glu Pro Met Phe Phe 50 55 60

Page 1265

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Phe 65 Leu Ser Met Leu Ala 70 Ser Ala Asp Leu Ile Leu Cys Thr Thr Cys 75 80 Met Pro Lys Thr Leu Gly Ile Phe Trp Leu Lys Ser Gln Lys Ile Thr 85 90 95 Phe Pro Gly Cys Leu Thr Gln Leu Phe Phe Leu His Phe Ser Phe Phe 100 105 110 Leu Asp Ser Ala Ile Leu Leu Gly Met Ala Phe Asp Arg Tyr Met Ala 115 120 125 Ile Cys Ser Pro Leu Arg Tyr Arg Ser Val Leu Thr Pro Arg Thr Ile 130 135 140 Val Lys Ile Met Val Gly Ile Val Gly Arg Ser Phe Ser Val Ile Leu 145 150 155 160 Pro Val Val Phe Leu Val Lys Arg Leu Pro Phe Cys Arg Thr Arg Ile 165 170 175 Ile Pro His Thr Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys 180 185 190 Ala Asp Ile Ser Ile Asn Ile Trp Tyr Gly Phe Ala Val Pro Val Met 195 200 205 Thr Ile Ile Ser Asp Leu Ile Leu Ile Gly Ile Ser Tyr Ser Leu Ile 210 215 220 Leu His Ala Val Phe His Leu Pro Ser Arg Asp Ala Arg Gln Lys Ala 225 230 235 240 Leu Ser Thr Cys Gly Ser His Val Ser Val Ile Leu Ile Phe Tyr Thr 245 250 255 Pro Ala Met Phe Ser Val Leu Thr His Arg Phe Gly His Asn Ile Ser 260 265 270

Page 1266

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Leu Thr Phe His Ile Met Phe Ala Asn Leu Tyr Val Ala Ile Pro Pro 275 280 285 Ala Leu Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 Lys Ile Ile Leu Leu Phe Phe Pro Lys Gly Met Gln 305 310 315

<210> 1127 <211> 981 <212> DNA <213> Canis familiaris <400> 1127

atggcccttt catctgccac cagcccagct gctgtgaatg actctgacac tcgagtggcc 60 ggctgcctcc tcattggcat ccctgggctg gagcatctgc acatctggct ctccatcccc 120 ttctgtacta tgtatgcagc tgccctggca ggcaatggca ttttaatttg tgtcatcctc 180 tcccagccaa gcctgcatga gcctatgtac atattcctgt ccatgttggc cagtgcggat 240 atcttgctct ccacttccac catgcccaaa gcactggcca acttctggct gggttcaagc 300 catatttcct tcgatggctg cctcacccag atgttcttca tccatttcct cttcgtggct 360 gactctgcgg tcctgctggc catggccttt gaccgctttg tggctatctg ctaccctctg 420 cgatattcca caatcctgac gaagacggtc attgggaaga tcgttgctgc caccctgacc 480 cgcagcttca tcatcatgtt tccatcagtc tttcttctca agcgcctgca ctattgccgg 540 ataaacatca ttgcacacac tttttgtgag cacatgggca tcgcccgtct gtcctgttct 600 gatatctcca tcaatatctg gtatgggttg gcagctgctc tactctccac aggcctggac 660 atcatcctta tcactgtttc ctacattcac atcctccaag ctgtcttcca cctcccttct 720 caaaatgccc ggtccaaggc cctgagcacg tgtggctccc atgtctgtgt catcctactc 780 ttctatatcc ctgccctctt ctctgtcttt gcctacagat ttggtaggaa acgcatccca 840 cgctatgtcc atatcctctt ggctaacctc tatgtggtca tcccacctat gctcaatccc 900 attatttatg gagtgaggac caagcagatt tgggaagggg ttaaacagat gttttcacat 960 cttgtccagg aatctaaata a 981

Page 1267

069269_0225_SL.TXT <210> 1128 <211> 326 <212> PRT <213> Canis familiaris

<400> 1128 Met 1 Ala Leu Ser Ser Ala 5 Thr Ser Pro Ala 10 Ala Val Asn Asp Ser 15 Asp Thr Arg Val Ala Gly Cys Leu Leu Ile Gly Ile Pro Gly Leu Glu His 20 25 30 Leu His Ile Trp Leu Ser Ile Pro Phe Cys Thr Met Tyr Ala Ala Ala 35 40 45 Leu Ala Gly Asn Gly Ile Leu Ile Cys Val Ile Leu Ser Gln Pro Ser 50 55 60 Leu His Glu Pro Met Tyr Ile Phe Leu Ser Met Leu Ala Ser Ala Asp 65 70 75 80 Ile Leu Leu Ser Thr Ser Thr Met Pro Lys Ala Leu Ala Asn Phe Trp 85 90 95 Leu Gly Ser Ser His Ile Ser Phe Asp Gly Cys Leu Thr Gln Met Phe 100 105 110 Phe Ile His Phe Leu Phe Val Ala Asp Ser Ala Val Leu Leu Ala Met 115 120 125 Ala Phe Asp Arg Phe Val Ala Ile Cys Tyr Pro Leu Arg Tyr Ser Thr 130 135 140 Ile Leu Thr Lys Thr Val Ile Gly Lys Ile Val Ala Ala Thr Leu Thr 145 150 155 160 Arg Ser Phe Ile Ile Met Phe Pro Ser Val Phe Leu Leu Lys Arg Leu 165 170 175 His Tyr Cys Arg Ile Asn Ile Ile Ala His Thr Phe Cys Glu His Met

Page 1268

180

069269_0225_SL.TXT 185 190

Gly Ile Ala Arg Leu Ser Cys Ser Asp Ile Ser Ile Asn Ile Trp Tyr 195 200 205 Gly Leu Ala Ala Ala Leu Leu Ser Thr Gly Leu Asp Ile Ile Leu Ile 210 215 220 Thr Val Ser Tyr Ile His Ile Leu Gln Ala Val Phe His Leu Pro Ser 225 230 235 240 Gln Asn Ala Arg Ser Lys Ala Leu Ser Thr Cys Gly Ser His Val Cys 245 250 255 Val Ile Leu Leu Phe Tyr Ile Pro Ala Leu Phe Ser Val Phe Ala Tyr 260 265 270 Arg Phe Gly Arg Lys Arg Ile Pro Arg Tyr Val His Ile Leu Leu Ala 275 280 285 Asn Leu Tyr Val Val Ile Pro Pro Met Leu Asn Pro Ile Ile Tyr Gly 290 295 300 Val Arg Thr Lys Gln Ile Trp Glu Gly Val Lys Gln Met Phe Ser His 305 310 315 320 Leu Val Gln Glu Ser Lys 325

<210> 1129 <211> 954 <212> DNA <213> Canis familiaris <400> 1129 atgactgcct taaaccacac tgctgttagt cacacagtct tccagttgtt gggtatccct gggctagaag accagcacat gtggatttcc atccccttct tcatttccta cgtcattgcc ctgcttggga acagcttgct catctgcatt atcctcacaa agtgcagcct ccatgaaccc atgtacctct tcctctgaat gctggccgga gcagacgttg tcctctccac gtgcacagta

120

180

240

Page 1269

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ccccaggcct tggccatctt ctggttccgt gctggggaga tctccttgga tcgctgcatc 300 actcagttct tcatcataca ttgcactttc atgtctgagt cagggatatt gctggtgatg 360 gcctttgacc gctacattgc catatgctac ccactgagat acaccactat tcttacacaa 420 gcactgattg ggaaaatcgt gactgtcttt ctgagaagtt tttgtacact tttccccata 480 atatttcttt tgaaaagatt gactttctgc caaaataata ccattccaca caccttttgt 540 gaacacattg gcttggccaa atatgcttgt aatgacattc aagtgaacat ctggtatgga 600 ttttccatcc taatgttaac agtggtttta gatgtagtgc taatttttgt ttcctatgtg 660 ctgattctcc atgctgtctt ccacatccct tctcaagatg ctcgccacaa agccctcaac 720 acctgtggtt cccacatctg tgtcatcatc cttttttatg ggcctggaat cttcacaatc 780 cttactcaac ggtttggacg ccacattcca cctcataccc acatcttgtt ggctaatgtt 840 tgcatgcttg ccccacctat gctcaatccc atcatttatg ggatcaagac caagcaaatc 900 cgggtgcagg tggttcatgt gttgttcaca aagcagaaat cactttggtt taaa 954

<210> 1130 <211> 252 <212> PRT <213> Canis familiaris

<400> 1130 Met Leu Ala Gly 1 Ala 5 Asp Val Val Leu Ser Thr Cys Thr Val Pro Gln 10 15 Ala Leu Ala Ile Phe Trp Phe Arg Ala Gly Glu Ile Ser Leu Asp Arg 20 25 30 Cys Ile Thr Gln Phe Phe Ile Ile His Cys Thr Phe Met Ser Glu Ser 35 40 45 Gly Ile Leu Leu Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Tyr 50 55 60 Pro Leu Arg Tyr Thr Thr Ile Leu Thr Gln Ala Leu Ile Gly Lys Ile 65 70 75 80

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Val Thr Val Phe Leu Arg Ser Phe Cys Thr Leu Phe Pro Ile Ile Phe 85 90 95 Leu Leu Lys Arg Leu Thr Phe Cys Gln Asn Asn Thr Ile Pro His Thr 100 105 110 Phe Cys Glu His Ile Gly Leu Ala Lys Tyr Ala Cys Asn Asp Ile Gln 115 120 125 Val Asn Ile Trp Tyr Gly Phe Ser Ile Leu Met Leu Thr Val Val Leu 130 135 140 Asp Val Val Leu Ile Phe Val Ser Tyr Val Leu Ile Leu His Ala Val 145 150 155 160 Phe His Ile Pro Ser Gln Asp Ala Arg His Lys Ala Leu Asn Thr Cys 165 170 175 Gly Ser His Ile Cys Val Ile Ile Leu Phe Tyr Gly Pro Gly Ile Phe 180 185 190 Thr Ile Leu Thr Gln Arg Phe Gly Arg His Ile Pro Pro His Thr His 195 200 205 Ile Leu Leu Ala Asn Val Cys Met Leu Ala Pro Pro Met Leu Asn Pro 210 215 220 Ile Ile Tyr Gly Ile Lys Thr Lys Gln Ile Arg Val Gln Val Val His 225 230 235 240 Val Leu Phe Thr Lys Gln Lys Ser Leu Trp Phe Lys

245 250 <210> 1131 <211> 942 <212> DNA <213> Canis familiaris <400> 1131 atgtataatc tgagctgtta cgatcctggt tcctttatcc ttgtggggat acctggcctg

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gagaagtttc acatctggat cgggattccc ttttgtgtca tctatgttct ggctcttgtg 120 ggtaactgca ccctcctcta cctcattgca gtggagcaca gcctccatga gcccatgttt 180 ttcttcctag ctatgctggc taccacggac ctcatcctgt ccactgccac agtgcccaaa 240 ctgctcacta acctctggct gcactcccag gaaataacct tctctggctg tctcacccag 300 atgtttttcc tccacttcag ctttgtagtc gactcagcca tcctgttggc catggcattt 360 gatcgctacg ttgccatctg cttccccttg aggtacacca ccatcctgac tcctcaggtg 420 atcatcaagc ttgcagcgag cattgttgtg aggagcttct ctgtcatctt gccagatgtt 480 tttctgctga aacggttacc cttctgtggg acacgcatca taccacacac atactgtgag 540 cacataggtg ttgctcggct tgcctctgct gacatctcca tcaacatctg gtatggcttt 600 tctgtgcctc ttatgactgt catctcagat gtgatcatta ttgctgtttc ctataccttc 660 atcctccgtg ctgtctttca gctctcatct cagggtgccc gccagaaggc cctcagcact 720 tgtggttctc atgtctgtgt cattctcatg ttttacacac ctgccttctt ctccatcctt 780 gcccatcgct ttgggcatag tgtccctcga aatgtgctta tcctgtttgc caacctctat 840 gtggccatcc cccccgctct caatcctatt gtctatggag tgaagactaa gcagatccag 900 gacaaattta ttctcctctt ctctttgaag aagacacaat ga 942

<210> 1132 <211> 313 <212> PRT <213> Canis familiaris <400> 1132

Met Tyr Asn Leu Ser Cys Tyr Asp Pro Gly Ser Phe Ile Leu Val Gly 1 5 10 15 Ile Pro Gly Leu Glu Lys Phe His Ile Trp Ile Gly Ile Pro Phe Cys 20 25 30 Val Ile Tyr Val Leu Ala Leu Val Gly Asn Cys Thr Leu Leu Tyr Leu 35 40 45 Ile Ala Val Glu His Ser Leu His Glu Pro Met Phe Phe Phe Leu Ala 50 55 60

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Met 65 Leu Ala Thr Thr Asp Leu Ile Leu Ser Thr Ala Thr Val Pro Lys 70 75 80 Leu Leu Thr Asn Leu Trp Leu His Ser Gln Glu Ile Thr Phe Ser Gly 85 90 95 Cys Leu Thr Gln Met Phe Phe Leu His Phe Ser Phe Val Val Asp Ser 100 105 110 Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Phe 115 120 125 Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro Gln Val Ile Ile Lys Leu 130 135 140 Ala Ala Ser Ile Val Val Arg Ser Phe Ser Val Ile Leu Pro Asp Val 145 150 155 160 Phe Leu Leu Lys Arg Leu Pro Phe Cys Gly Thr Arg Ile Ile Pro His 165 170 175 Thr Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Ser Ala Asp Ile 180 185 190 Ser Ile Asn Ile Trp Tyr Gly Phe Ser Val Pro Leu Met Thr Val Ile 195 200 205 Ser Asp Val Ile Ile Ile Ala Val Ser Tyr Thr Phe Ile Leu Arg Ala 210 215 220 Val Phe Gln Leu Ser Ser Gln Gly Ala Arg Gln Lys Ala Leu Ser Thr 225 230 235 240 Cys Gly Ser His Val Cys Val Ile Leu Met Phe Tyr Thr Pro Ala Phe 245 250 255 Phe Ser Ile Leu Ala His Arg Phe Gly His Ser Val Pro Arg Asn Val 260 265 270

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Leu Ile Leu 275 Phe Ala Asn Leu Tyr Val Ala Ile Pro Pro Ala Leu Asn 280 285 Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Gln Asp Lys Phe Ile 290 295 300 Leu Leu Phe Ser Leu Lys Lys Thr Gln 305 310

<210> 1133 <211> 948 <212> DNA <213> Canis familiaris <400> 1133

atggtggcca cattcaactt gagcagcttc aatccgggcc cattcatctt actgggaatc 60 ccagggctgg aggagtttca tgtctggatt gggattctct tctttattat ctatcttgtg 120 gccctggcgg gcaacagcat ccttctctac cttatttcca tggagcgtac ccttcatgag 180 cccatgttct ttttcctctc catgctggct gctacagatg tcatcctgtc taatacatgt 240 gtacccaaaa cattcagcat cttctggcta ggtcctcagg aaatcacttt tcctgcatgc 300 cttactcaga tgttctttct ccactacagc tttgctatgg attctgctat tctgctggct 360 atggcatttg atcgctatgt tgctatttgc ttccccctaa ggtatacgaa tattctcacc 420 cgtcagatta ttactaagat tgtagtggct attgtcagca ggagcttttg tatcatcttc 480 ccatgtgtct tcctattaaa gagactgcct ttttgccgaa cactcttcat tccacacaca 540 tactgtgagc acataggcat agcccaacta gcctgtgcgg atatctccat caacatctgg 600 tatggattag ctgtacctat aatgactgtc acatcagact tgatccttat tggcatctcc 660 tacggtctca tccttcgtgc cgtctttaac cttccatctc gagatgcccg caagaaagcc 720 ctcaacacgt gtggttccca tgtttgtgtc attcttatat tctatacacc agccatgttc 780 tctgtcctca cccaccgttt tggtcacaat attcctcgct ctttccacat actgactgcc 840 aacctctatg tagccatccc tcctgcactc aatccaatca tctatggggt gaagaccaag 900 cagattcggg agaaaatcat cttacccttc ttctctaaag ggaattag 948

Page 1274

069269_0225_SL.TXT <210> 1134 <211> 315 <212> PRT <213> Canis familiaris

<400> 1134 Phe 15 Ile Met 1 Val Ala Thr Phe Asn Leu Ser 5 Ser Phe 10 Asn Pro Gly Pro Leu Leu Gly Ile Pro Gly Leu Glu Glu Phe His Val Trp Ile Gly Ile 20 25 30 Leu Phe Phe Ile Ile Tyr Leu Val Ala Leu Ala Gly Asn Ser Ile Leu 35 40 45 Leu Tyr Leu Ile Ser Met Glu Arg Thr Leu His Glu Pro Met Phe Phe 50 55 60 Phe Leu Ser Met Leu Ala Ala Thr Asp Val Ile Leu Ser Asn Thr Cys 65 70 75 80 Val Pro Lys Thr Phe Ser Ile Phe Trp Leu Gly Pro Gln Glu Ile Thr 85 90 95 Phe Pro Ala Cys Leu Thr Gln Met Phe Phe Leu His Tyr Ser Phe Ala 100 105 110 Met Asp Ser Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 Ile Cys Phe Pro Leu Arg Tyr Thr Asn Ile Leu Thr Arg Gln Ile Ile 130 135 140 Thr Lys Ile Val Val Ala Ile Val Ser Arg Ser Phe Cys Ile Ile Phe 145 150 155 160 Pro Cys Val Phe Leu Leu Lys Arg Leu Pro Phe Cys Arg Thr Leu Phe 165 170 175 Ile Pro His Thr Tyr Cys Glu His Ile Gly Ile Ala Gln Leu Ala Cys 180 185 190

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Ala Asp Ile 195 Ser Ile Asn Ile Trp Tyr Gly Leu Ala Val Pro Ile Met 200 205 Thr Val Thr Ser Asp Leu Ile Leu Ile Gly Ile Ser Tyr Gly Leu Ile 210 215 220 Leu Arg Ala Val Phe Asn Leu Pro Ser Arg Asp Ala Arg Lys Lys Ala 225 230 235 240 Leu Asn Thr Cys Gly Ser His Val Cys Val Ile Leu Ile Phe Tyr Thr 245 250 255 Pro Ala Met Phe Ser Val Leu Thr His Arg Phe Gly His Asn Ile Pro 260 265 270 Arg Ser Phe His Ile Leu Thr Ala Asn Leu Tyr Val Ala Ile Pro Pro 275 280 285 Ala Leu Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu 290 295 300 Lys Ile Ile Leu Pro Phe Phe Ser Lys Gly Asn 305 310 315

<210> 1135 <211> 951 <212> DNA <213> Canis familiaris <400> 1135

atgctttctg catcggtcac caatgacact gccttccatc cctccacatt tattctactt 60 ggaatccctg ggatgcaaga ccagcacatg tgggctgcca tacccttctg ctccatgtat 120 atccttgctc tggttggcaa tggcaccatc ctctacatca tcatgacaga tagaactctg 180 catgagccaa tgtacctctt cctgtgccta ctttctatca ccgacctgat tctctgttct 240 accacactgc ccaagatgct aacaatcttc tggctcaggt cccacataat ttcctaccat 300 ggctgtctca cacaaatgtt ttttgttcac actatctttg ccacagagtc agcagttcta 360

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ctggccatgg cttttgaccg ctatgtggct atctgccgtc cgcttcatta tacatccatc 420 ctcaatgcta cagtgattgg gaagattggt ctggcatgtg tggtccgtgg tcttctcttt 480 gtcttcccct ttgttatcct catcgaacgc ttacccttct gtggacatca catcatcccc 540 cacacctact gtgagcacat gggcattgcc aagctggctt gtgccagcat caagcccaac 600 accatttatg gtctcactgt ggcactttca gtcactggca tggatgtggt cctcattgcc 660 acctcctatg gcctgatcct tcgggcagtg ctgcgcctac cctccaagga tgcccaattc 720 cgagcattta gcacttgtgg agctcacatt tgtgtgattc ttgttttcta tgtacctgcc 780 tttttttcct ttttcaccca ccgctttggc caccaagtac ctcctcatgt ccacattgta 840 cttgcaaatc tctaccttct tgtgccccct gttctcaacc ccctggtcta tggcattaat 900 accaaacaga <210> 1136 <211> 316 <212> PRT <213> Canis <400> 1136 tccgtctgag aatatttggc familiaris ttttttatgg gaaggaggta ^g 951 Met Leu Ser 1 Ala Ser Val Thr Asn 5 Asp Thr Ala 10 Phe His Pro Ser Thr 15 Phe Ile Leu Leu Gly Ile Pro Gly 20 Met Gln Asp 25 Gln His Met 30 Trp Ala Ala Ile Pro 35 Phe Cys Ser Met Tyr 40 Ile Leu Ala Leu Val Gly 45 Asn Gly Thr Ile Leu 50 Tyr Ile Ile Met Thr 55 Asp Arg Thr Leu His Glu 60 Pro Met Tyr Leu Phe 65 Leu Cys Leu Leu Ser 70 Ile Thr Asp 75 Leu Ile Leu Cys Ser 80 Thr Thr Leu Pro Lys Met Leu Thr 85 Ile Phe Trp 90 Leu Arg Ser His Ile 95 Ile Ser Tyr His Gly Cys Leu Thr Gln Met Phe Phe Val His Thr Ile

Page 1277

100

069269_0225_SL.TXT 105 110

Phe Ala Thr 115 Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr 120 125 Val Ala Ile Cys Arg Pro Leu His Tyr Thr Ser Ile Leu Asn Ala Thr 130 135 140 Val Ile Gly Lys Ile Gly Leu Ala Cys Val Val Arg Gly Leu Leu Phe 145 150 155 160 Val Phe Pro Phe Val Ile Leu Ile Glu Arg Leu Pro Phe Cys Gly His 165 170 175 His Ile Ile Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Lys Leu 180 185 190 Ala Cys Ala Ser Ile Lys Pro Asn Thr Ile Tyr Gly Leu Thr Val Ala 195 200 205 Leu Ser Val Thr Gly Met Asp Val Val Leu Ile Ala Thr Ser Tyr Gly 210 215 220 Leu Ile Leu Arg Ala Val Leu Arg Leu Pro Ser Lys Asp Ala Gln Phe 225 230 235 240 Arg Ala Phe Ser Thr Cys Gly Ala His Ile Cys Val Ile Leu Val Phe 245 250 255 Tyr Val Pro Ala Phe Phe Ser Phe Phe Thr His Arg Phe Gly His Gln 260 265 270 Val Pro Pro His Val His Ile Val Leu Ala Asn Leu Tyr Leu Leu Val 275 280 285 Pro Pro Val Leu Asn Pro Leu Val Tyr Gly Ile Asn Thr Lys Gln Ile 290 295 300 Arg Leu Arg Ile Phe Gly Phe Phe Met Gly Arg Arg

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305 310 315 <210> 1137 <211> 978 <212> DNA <213> Canis familiaris <400> 1137

atgactgtgt gcaatgtctc cctggggcat cctcctttct tcattctcca aggcattccc 60 gggatggagg acaaacacag atggatctct atccccttct gttccatgta cttcatcacc 120 atccttggga actgcaccat catcttcatc atctgcacag agcgctccct gcacaagccc 180 atgttcctgc tcctctgcat gttggccctc acagacctgg gcatgtccac taccaccatt 240 cccaaagtgc tatgcatctt ctggtttaga cacagtgaga tcagctatgt gggctgtctg 300 gtccaaatgt tcttcattca ctccatatcg gccatgcagt ctgccattct gatgaccatg 360 gcctttgacc gctacgtagc catctgtgag cccctgcgct atgccaccat cctttccaat 420 agtcgcattg ggctcattgg cttagtgagt ttagtaagag ccatcctttt cattctgccc 480 atgcctgtcc tcctccagaa gatgcctttt catgcgaatc atgtcatccc caccacctac 540 tgtgaacaca tggctgtggt gaagatggtg tgtgtggaca ccacagtcaa ccggatatat 600 ggtctggtgg tggccttgtt ggttgccggg ctagacatct cagctatcgc ctcctcttat 660 gtgcttatca tcaaggctgt cttgcgactg tcttctaagg aagcccacca caaagcagtc 720 aacacttgca ccactcatat ctgtgtcatg cttatctctt acacgccctc attgttctct 780 ttcctcactc accgctttgg caggggaatt ccactgcatg tgcacaccat tcttggaagt 840 ctctacttcc ttgtacctcc aatgctcaat cctattattt atgcagtgaa aaccaaggag 900 tttcgggaaa aactgatcaa atatgggtac tggaagaagg agctcaaaac cgttacccat 960 ggtccgaagc ctgtctga 978

<210> 1138 <211> 325 <212> PRT <213> Canis familiaris <400> 1138

Met Thr Val Cys Asn Val Ser Leu Gly His Pro Pro Phe Phe Ile Leu 1 5 10 15

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Gln Gly Ile Pro 20 Gly Met Glu Asp Lys His Arg Trp Ile Ser Ile Pro 25 30 Phe Cys Ser Met Tyr Phe Ile Thr Ile Leu Gly Asn Cys Thr Ile Ile 35 40 45 Phe Ile Ile Cys Thr Glu Arg Ser Leu His Lys Pro Met Phe Leu Leu 50 55 60 Leu Cys Met Leu Ala Leu Thr Asp Leu Gly Met Ser Thr Thr Thr Ile 65 70 75 80 Pro Lys Val Leu Cys Ile Phe Trp Phe Arg His Ser Glu Ile Ser Tyr 85 90 95 Val Gly Cys Leu Val Gln Met Phe Phe Ile His Ser Ile Ser Ala Met 100 105 110 Gln Ser Ala Ile Leu Met Thr Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Glu Pro Leu Arg Tyr Ala Thr Ile Leu Ser Asn Ser Arg Ile Gly 130 135 140 Leu Ile Gly Leu Val Ser Leu Val Arg Ala Ile Leu Phe Ile Leu Pro 145 150 155 160 Met Pro Val Leu Leu Gln Lys Met Pro Phe His Ala Asn His Val Ile 165 170 175 Pro Thr Thr Tyr Cys Glu His Met Ala Val Val Lys Met Val Cys Val 180 185 190 Asp Thr Thr Val Asn Arg Ile Tyr Gly Leu Val Val Ala Leu Leu Val 195 200 205 Ala Gly Leu Asp Ile Ser Ala Ile Ala Ser Ser Tyr Val Leu Ile Ile 210 215 220

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Lys Ala Val Leu Arg Leu Ser Ser Lys Glu Ala His His Lys Ala Val 240 225 230 235 Asn Thr Cys Thr Thr His Ile Cys Val Met Leu Ile Ser Tyr Thr Pro 245 250 255 Ser Leu Phe Ser Phe Leu Thr His Arg Phe Gly Arg Gly Ile Pro Leu 260 265 270 His Val His Thr Ile Leu Gly Ser Leu Tyr Phe Leu Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Ala Val Lys Thr Lys Glu Phe Arg Glu Lys 290 295 300 Leu Ile Lys Tyr Gly Tyr Trp Lys Lys Glu Leu Lys Thr Val Thr His 305 310 315 320 Gly Pro Lys Pro Val

325 <210> 1139 <211> 978 <212> DNA <213> Canis familiaris <400> 1139

atgactgtgt gcaatgtctc cctggggcat cctcctttct tcattctcca aggcattccc 60 gggatggagg acaaacacag atggatctct atccccttct gttccatgta cttcatcacc 120 atccttggga actgcaccat catcttcatc atctgcacag agcgctccct gcacaagccc 180 atgttcctgc tcctctgcat gttggccctc acagacctgg gcatgtccac taccaccatt 240 cccaaagtgc tatgcatctt ctggtttaga cacagtgaga tcagctatgt gggctgtctg 300 gtccaaatgt tcttcattca ctccatatct gtcatgcagt ctgccattct gatgaccatg 360 gcctttgacc gctacgtagc catctgtgag cccctgcgct atgccaccat cctttccaat 420 agtcgcattg ggctcattgg cttagtgagt ttagtaagag ccatcctttt cattctgccc 480

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atgcctgtcc tcctccagaa gatgcctttt catgggaatc atgtcatccc caccacctac 540 tgtgaacaca tggctgtggt gaagatggtg tgtgtggaca ccacagtcaa ccggatatat 600 ggtctggtgg tggccttgtt ggttgccggg ctagacatct cagctattgc ctcctcttat 660 gtgcttatca tccaggctgt cctgcggctg tcttctaagg aagcccacca caaagcagtc 720 aacacctgca ctgcacacat tgttgtcatg cttctctact atactccctc actgttctct 780 ttcctcactc accgctttgg caggggaatt ccactgcatg tgcacaccat tcttggaaac 840 ctctacttcc ttatacctcc aatgctcaat cctattattt atgcagtgaa aaccaaggag 900 tttcgggaaa aactgaccaa atatgggtac tggatgaaaa agcacataat cagtaaccat 960 ggtcagaatc ctttctaa 978

<210> 1140 <211> 325 <212> PRT <213> Canis familiaris <400> 1140

Met Thr Val Cys Asn Val Ser Leu Gly His Pro Pro Phe Phe Ile Leu 1 5 10 15 Gln Gly Ile Pro Gly Met Glu Asp Lys His Arg Trp Ile Ser Ile Pro 20 25 30 Phe Cys Ser Met Tyr Phe Ile Thr Ile Leu Gly Asn Cys Thr Ile Ile 35 40 45 Phe Ile Ile Cys Thr Glu Arg Ser Leu His Lys Pro Met Phe Leu Leu 50 55 60 Leu Cys Met Leu Ala Leu Thr Asp Leu Gly Met Ser Thr Thr Thr Ile 65 70 75 80 Pro Lys Val Leu Cys Ile Phe Trp Phe Arg His Ser Glu Ile Ser Tyr 85 90 95 Val Gly Cys Leu Val Gln Met Phe Phe Ile His Ser Ile Ser Val Met 100 105 110

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Gln Ser Ala 115 Ile Leu Met Thr Met Ala Phe Asp Arg Tyr Val Ala Ile 120 125 Cys Glu Pro Leu Arg Tyr Ala Thr Ile Leu Ser Asn Ser Arg Ile Gly 130 135 140 Leu Ile Gly Leu Val Ser Leu Val Arg Ala Ile Leu Phe Ile Leu Pro 145 150 155 160 Met Pro Val Leu Leu Gln Lys Met Pro Phe His Gly Asn His Val Ile 165 170 175 Pro Thr Thr Tyr Cys Glu His Met Ala Val Val Lys Met Val Cys Val 180 185 190 Asp Thr Thr Val Asn Arg Ile Tyr Gly Leu Val Val Ala Leu Leu Val 195 200 205 Ala Gly Leu Asp Ile Ser Ala Ile Ala Ser Ser Tyr Val Leu Ile Ile 210 215 220 Gln Ala Val Leu Arg Leu Ser Ser Lys Glu Ala His His Lys Ala Val 225 230 235 240 Asn Thr Cys Thr Ala His Ile Val Val Met Leu Leu Tyr Tyr Thr Pro 245 250 255 Ser Leu Phe Ser Phe Leu Thr His Arg Phe Gly Arg Gly Ile Pro Leu 260 265 270 His Val His Thr Ile Leu Gly Asn Leu Tyr Phe Leu Ile Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Ala Val Lys Thr Lys Glu Phe Arg Glu Lys 290 295 300 Leu Thr Lys Tyr Gly Tyr Trp Met Lys Lys His Ile Ile Ser Asn His 305 310 315 320

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Gly Gln Asn Pro Phe 325 <210> 1141 <211> 978 <212> DNA <213> Canis familiaris <400> 1141

atgactgtgt gcaatgtctc cctggggcat cctcctttct tcattctcca aggcattccc 60 gggatggagg acaaacacag atggatctct atccccttct gttccatgta cttcatcacc 120 atccttggga actgcaccat catcttcatc atctgcacag agcgctccct gcacaagccc 180 atgttcctgc tcctctgcat gttggccctc acagacctgg gcatgtccac taccaccatt 240 cccaaagtgc tatgcatctt ctggtttaga cacagtgaga tcagctacgt gggctgtctg 300 gtccaaatgt tcttcattca ctccatatcg gccatgcagt ctgccattct gatgaccatg 360 gcctttgacc gctacgtagc catctgtgag cccctgcgct atgccaccat cctttccaat 420 agtcgcattg ggctcattgg cttagtgggt ttagtaagag ccatcctttt cattctgccc 480 atgcctgtac tcctccagaa gatgcctttt catgcgaatc atgttatccc caccacctac 540 tgtgaacaca tggctgtggt gaagatggtg tgtgtggaca ccacagtcaa ccggatatat 600 ggtctggtgg tggccttgtt agttgccggg atagacatct cagctattgc ctcctcttat 660 gtgcttatca tccaggctgt cctgcggctg tcttctaagg aagcccacca caaagcagtc 720 aacacctgca ctgcacacat tgttgtcatg cttctctact atactccctc actgttctct 780 ttcctcactc accgctttgg caggggaatt ccaccccatg tgcacaccat tcttggaaac 840 ctctacttcc ttatacctcc aatgctcaat cctattattt atgcagtgaa aaccaaggag 900 tttcgggaaa aactgaccaa atatgggtac tggatgaagg agcacataat cagcaaccat 960 ggtcagaatc ctttctaa 978

<210> 1142 <211> 325 <212> PRT <213> Canis familiaris <400> 1142

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Met 1 Thr Val Cys Asn 5 Val Ser Leu Gly His Pro Pro Phe Phe Ile Leu 10 15 Gln Gly Ile Pro Gly Met Glu Asp Lys His Arg Trp Ile Ser Ile Pro 20 25 30 Phe Cys Ser Met Tyr Phe Ile Thr Ile Leu Gly Asn Cys Thr Ile Ile 35 40 45 Phe Ile Ile Cys Thr Glu Arg Ser Leu His Lys Pro Met Phe Leu Leu 50 55 60 Leu Cys Met Leu Ala Leu Thr Asp Leu Gly Met Ser Thr Thr Thr Ile 65 70 75 80 Pro Lys Val Leu Cys Ile Phe Trp Phe Arg His Ser Glu Ile Ser Tyr 85 90 95 Val Gly Cys Leu Val Gln Met Phe Phe Ile His Ser Ile Ser Ala Met 100 105 110 Gln Ser Ala Ile Leu Met Thr Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Glu Pro Leu Arg Tyr Ala Thr Ile Leu Ser Asn Ser Arg Ile Gly 130 135 140 Leu Ile Gly Leu Val Gly Leu Val Arg Ala Ile Leu Phe Ile Leu Pro 145 150 155 160 Met Pro Val Leu Leu Gln Lys Met Pro Phe His Ala Asn His Val Ile 165 170 175 Pro Thr Thr Tyr Cys Glu His Met Ala Val Val Lys Met Val Cys Val 180 185 190 Asp Thr Thr Val Asn Arg Ile Tyr Gly Leu Val Val Ala Leu Leu Val 195 200 205

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Ala Gly Ile Asp Ile Ser Ala Ile Ala Ser Ser Tyr Val Leu Ile Ile 210 215 220 Gln Ala Val Leu Arg Leu Ser Ser Lys Glu Ala His His Lys Ala Val 225 230 235 240 Asn Thr Cys Thr Ala His Ile Val Val Met Leu Leu Tyr Tyr Thr Pro 245 250 255 Ser Leu Phe Ser Phe Leu Thr His Arg Phe Gly Arg Gly Ile Pro Pro 260 265 270 His Val His Thr Ile Leu Gly Asn Leu Tyr Phe Leu Ile Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Ala Val Lys Thr Lys Glu Phe Arg Glu Lys 290 295 300 Leu Thr Lys Tyr Gly Tyr Trp Met Lys Glu His Ile Ile Ser Asn His 305 310 315 320 Gly Gln Asn Pro Phe

325 <210> 1143 <211> 936 <212> DNA <213> Canis familiaris <400> 1143

atgttaatct tcaaccattc cagcttcctg accttcacat tgatgggcat accaggctta 60 gagtcacagc acttgtggtt atctcttcct ttctcctcta tgtttttggc tattctcatt 120 ggcaatggtg ctattctctt tctggtggcc atagaaccca cattgcacag tccaatgtat 180 ctgctcctgg ccttgctgat ggtggctgac ctcatatcta ctctggcact gttgcccaag 240 ctcctctgcc tcttcttgtt caatgatcgg gacatagctg ccaatgcctg cttcacccag 300 atgtttttca tccatggaac atctgtggta cgatcagccc tatttgtggc aatggccttt 360 gaccgcttcg tggctgtgtg tgagccttta cgctacaaca caattctgag tcattcctta 420

Page 1286

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gttggacgcc tgggactgct ggctttagcc aagggtgtga ttcttatcct acccatgcct 480 cttctacttc gaagattgac attctgccaa atggtcattc ctcataccta ctgtgaccac 540 atggctgtgg tgaaaatggc ctgtggccat acaagaccta accgtatcta tgggctcttt 600 gtgattcttc ttgtggtggg acttgatttg ctgctaattg gtttctctta tggcctcatc 660 ttgcaatctg tggtacgcct caactctcga gatgcaactt gcaaagccct caacacctgt 720 tcagcccact tctttgtcat tcttgtcact tatgtgcctg cactcttttc atctctcact 780 caccgcatag gtcacaacat cccacctcat gctcatgttc tccttgccaa tctttatctt 840 cttctaccct cagtactcaa ccccatcatc tatggcataa aaatgaagga aatacggcac 900 aaggtggcca aatgcctttg cagaggatct gcatag 936

<210> 1144 <211> 311 <212> PRT <213> Canis familiaris <400> 1144

Met 1 Leu Ile Phe Asn His Ser Ser Phe Leu Thr Phe Thr Leu Met Gly 5 10 15 Ile Pro Gly Leu Glu Ser Gln His Leu Trp Leu Ser Leu Pro Phe Ser 20 25 30 Ser Met Phe Leu Ala Ile Leu Ile Gly Asn Gly Ala Ile Leu Phe Leu 35 40 45 Val Ala Ile Glu Pro Thr Leu His Ser Pro Met Tyr Leu Leu Leu Ala 50 55 60 Leu Leu Met Val Ala Asp Leu Ile Ser Thr Leu Ala Leu Leu Pro Lys 65 70 75 80 Leu Leu Cys Leu Phe Leu Phe Asn Asp Arg Asp Ile Ala Ala Asn Ala 85 90 95 Cys Phe Thr Gln Met Phe Phe Ile His Gly Thr Ser Val Val Arg Ser 100 105 110

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Ala Leu Phe 115 Val Ala Met Ala Phe Asp Arg Phe Val Ala Val Cys Glu 120 125 Pro Leu Arg Tyr Asn Thr Ile Leu Ser His Ser Leu Val Gly Arg Leu 130 135 140 Gly Leu Leu Ala Leu Ala Lys Gly Val Ile Leu Ile Leu Pro Met Pro 145 150 155 160 Leu Leu Leu Arg Arg Leu Thr Phe Cys Gln Met Val Ile Pro His Thr 165 170 175 Tyr Cys Asp His Met Ala Val Val Lys Met Ala Cys Gly His Thr Arg 180 185 190 Pro Asn Arg Ile Tyr Gly Leu Phe Val Ile Leu Leu Val Val Gly Leu 195 200 205 Asp Leu Leu Leu Ile Gly Phe Ser Tyr Gly Leu Ile Leu Gln Ser Val 210 215 220 Val Arg Leu Asn Ser Arg Asp Ala Thr Cys Lys Ala Leu Asn Thr Cys 225 230 235 240 Ser Ala His Phe Phe Val Ile Leu Val Thr Tyr Val Pro Ala Leu Phe 245 250 255 Ser Ser Leu Thr His Arg Ile Gly His Asn Ile Pro Pro His Ala His 260 265 270 Val Leu Leu Ala Asn Leu Tyr Leu Leu Leu Pro Ser Val Leu Asn Pro 275 280 285 Ile Ile Tyr Gly Ile Lys Met Lys Glu Ile Arg His Lys Val Ala Lys 290 295 300 Cys Leu Cys Arg Gly Ser Ala

305 310

Page 1288

069269_0225_SL.TXT <210> 1145 <211> 954 <212> DNA <213> Canis familiaris <400> 1145

atggtggacc ccaatggcaa tgaatccagt gccacatatt ttattttaat aggcctccca 60 ggcttggaag aagctcagtt ctggttggcc ttccccttgt gctccctcta ctttattgct 120 gtattgggta acctgacaat catctacatt gtgcggactg agcacagcct acatgaaccc 180 atgtatgttt ttctttgcat gctttctggc cttgacatcc ttatctccac ctcatctatg 240 cccaaaatga tggccatctt ctggttcaat tccactacca tccagtttga tgcttgtcta 300 ctacagatgt ttgccatcca ttctttatct ggcatggagt ccacagtact gctggccatg 360 gcctttgacc gctatgtggc catttgccac ccactacgcc atgccactgt actaacattg 420 cctcgtgtta tgaagattgg catggctgct gtggtacggg gtactgcact tatggcaccc 480 ctgcctgttt ttatcaaacg actgcctttc tgccactcca acattctttc ccattcctac 540 tgcctacacc aagatgtcat gaagctggct tgtgctgaca tccgtgtcaa tatcatctat 600 ggcctcattg tcatcatctc tgccattggc ctggactcac ttctcatctc cttgtcatat 660 ctacttatcc tcaagactgt gttgggcttg acacgtgaag cccaggcaaa ggcatttggc 720 acttgtgtct ctcatgtatg tgctgttttc atattctatg tacctttcat tggattatct 780 atggtgcacc gctttggcaa gagacatgac tccttcctgc ccatcattat ggccaacacc 840 tacctacttg tacctcctgt gctcaacccc attgtttatg gagtcaagac aaaggagatc 900 tggcagcgta tccttcgtct tttccatgtg accaaccata cttcagatct ctag 954

<210> 1146 <211> 317 <212> PRT <213> Canis familiaris <400> 1146

Met Val Asp Pro Asn Gly Asn Glu Ser Ser Ala Thr Tyr Phe Ile Leu 1 5 10 15 Ile Gly Leu Pro Gly Leu Glu Glu Ala Gln Phe Trp Leu Ala Phe Pro

20 25 30

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Leu Cys Ser 35 Leu Tyr Phe Ile Ala Val Leu Gly Asn Leu Thr Ile Ile 40 45 Tyr Ile Val Arg Thr Glu His Ser Leu His Glu Pro Met Tyr Val Phe 50 55 60 Leu Cys Met Leu Ser Gly Leu Asp Ile Leu Ile Ser Thr Ser Ser Met 65 70 75 80 Pro Lys Met Met Ala Ile Phe Trp Phe Asn Ser Thr Thr Ile Gln Phe 85 90 95 Asp Ala Cys Leu Leu Gln Met Phe Ala Ile His Ser Leu Ser Gly Met 100 105 110 Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg His Ala Thr Val Leu Thr Leu Pro Arg Val Met 130 135 140 Lys Ile Gly Met Ala Ala Val Val Arg Gly Thr Ala Leu Met Ala Pro 145 150 155 160 Leu Pro Val Phe Ile Lys Arg Leu Pro Phe Cys His Ser Asn Ile Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ala 180 185 190 Asp Ile Arg Val Asn Ile Ile Tyr Gly Leu Ile Val Ile Ile Ser Ala 195 200 205 Ile Gly Leu Asp Ser Leu Leu Ile Ser Leu Ser Tyr Leu Leu Ile Leu 210 215 220 Lys Thr Val Leu Gly Leu Thr Arg Glu Ala Gln Ala Lys Ala Phe Gly 225 230 235 240

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Thr Cys Val Ser His Val Cys Ala Val Phe Ile Phe Tyr Val Pro Phe 245 250 255 Ile Gly Leu Ser Met Val His Arg Phe Gly Lys Arg His Asp Ser Phe 260 265 270 Leu Pro Ile Ile Met Ala Asn Thr Tyr Leu Leu Val Pro Pro Val Leu 275 280 285 Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Glu Ile Trp Gln Arg Ile 290 295 300 Leu Arg Leu Phe His Val Thr Asn His Thr Ser Asp Leu 305 310 315

<210> 1147 <211> 981 <212> DNA <213> Canis familiaris <400> 1147 atgcctagag cttttgtcca gtctcctaat cacactaatc tggacccttc tgtttttttc ctcctgggca tcccaggtct ggaacaattt cacctgtggc tctcactccc cgtgtgctgc ctgggcacag ccacaattgt gggcaacatt accatcctgg ttgttgttgc cactgaacca gccctgcaca agcctgtata tttgttcctc tgcatgctct ctaccattga cttggctgcc tctttctcca cagttcccaa gctattggcc atcctctggt gtggagctgg acacatctct gcctctgcct gcctggcaca gatgttcttc attcatgcct tctgcatgat ggagtctact gtgcttctgg ccatggcctt tgatcgctat gtggccattt gtcacccact ccgttatgct actatcctca cggacaccat cattgcccga attggagtgg tagctatggt gcggggctcc atgctcatgc tcccatgtcc cttcctcatt gggcgtttga gcttctgcca aagccatgtg atcccccaca catactgtga gcacatggct gttgtgaagc tagcatgtgg agataccagg cctaaccgtg tgtatgggct gacagcagca ctattggtca taggggttga cttattctgc attggtcttt cctatgtctt tattgcacgg gctgtcctcc gtctttcatc ccatgaagct

120

180

240

300

360

420

480

540

600

660

720

Page 1291

069269_0225_SL.TXT cggtccaagg ccttggggac ctgtggttct catgtctgtg tcatcctaat ctcttataca ccagccctct tctccttttt tacccatcgc tttggccacc atgttccact tcatattcac attcttttgg ccaatgttta tctgctcttc ccacctgctc ttaaccctat ggtatatgga gttaaaacca aagaaatccg ggaaagggtt atcagggtgt ttcaaagggg gcagggaact gggttaaaag taccagagtg a

780

840

900

960

981 <210> 1148 <211> 326 <212> PRT <213> Canis familiaris <400> 1148

Met Pro Arg 1 Ala Phe Val Gln Ser 5 Pro Asn His Thr Asn Leu Asp Pro 10 15 Ser Val Phe Phe Leu Leu Gly Ile Pro Gly Leu Glu Gln Phe His Leu 20 25 30 Trp Leu Ser Leu Pro Val Cys Cys Leu Gly Thr Ala Thr Ile Val Gly 35 40 45 Asn Ile Thr Ile Leu Val Val Val Ala Thr Glu Pro Ala Leu His Lys 50 55 60 Pro Val Tyr Leu Phe Leu Cys Met Leu Ser Thr Ile Asp Leu Ala Ala 65 70 75 80 Ser Phe Ser Thr Val Pro Lys Leu Leu Ala Ile Leu Trp Cys Gly Ala 85 90 95 Gly His Ile Ser Ala Ser Ala Cys Leu Ala Gln Met Phe Phe Ile His 100 105 110 Ala Phe Cys Met Met Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp 115 120 125 Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Ala Thr Ile Leu Thr 130 135 140

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Asp 145 Thr Ile Ile Ala Arg 150 Ile Gly Val Val Ala Met Val Arg Gly Ser 155 160 Met Leu Met Leu Pro Cys Pro Phe Leu Ile Gly Arg Leu Ser Phe Cys 165 170 175 Gln Ser His Val Ile Pro His Thr Tyr Cys Glu His Met Ala Val Val 180 185 190 Lys Leu Ala Cys Gly Asp Thr Arg Pro Asn Arg Val Tyr Gly Leu Thr 195 200 205 Ala Ala Leu Leu Val Ile Gly Val Asp Leu Phe Cys Ile Gly Leu Ser 210 215 220 Tyr Val Phe Ile Ala Arg Ala Val Leu Arg Leu Ser Ser His Glu Ala 225 230 235 240 Arg Ser Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys Val Ile Leu 245 250 255 Ile Ser Tyr Thr Pro Ala Leu Phe Ser Phe Phe Thr His Arg Phe Gly 260 265 270 His His Val Pro Leu His Ile His Ile Leu Leu Ala Asn Val Tyr Leu 275 280 285 Leu Phe Pro Pro Ala Leu Asn Pro Met Val Tyr Gly Val Lys Thr Lys 290 295 300 Glu Ile Arg Glu Arg Val Ile Arg Val Phe Gln Arg Gly Gln Gly Thr 305 310 315 320 Gly Leu Lys Val Pro Glu

<210> 1149 <211> 969 <212> DNA

325

Page 1293

069269_0225_SL.TXT <213> Canis familiaris <400> 1149 atgatgctaa tgctgaacca aacagacctg actccaggtt cattcattct taatgggatc 60 ccaggactgg aagacatgca catgtggatt tccttcccat tctgctccat gtatattgtg 120 gccatggtag ggaattgtgg gcttctctac ctcatccact atgaggactc cctgcacagg 180 cccatgtact actttttagc tatgctttcc ctaactgacc ttttcatatg ctctagtaca 240 atccctaaag ccctcagcat actctggttc catttcaagg aaatcagctt tgatggatgc 300 ctggtccaga tgttctttgt ccatactttc acagggatgg agtctggggt tctcatgctc 360 atggccctgg accgctatgt ggccatctgc taccctctgc actattctac tgccctcacc 420 aattctgtta ttgcaaaggc tgggctctcc acctttctca gaggggtgtt gctcatcatt 480 cccttcactt tcctcacgaa gcgcctgccc tactgcagag gcaatataat tccccacacc 540 tactgtgacc acatgtctgt agccaaatta tcctgtgggg acatcaaggt caatgtcgtc 600 tatggtctga cagttgccct cctgattgga ggctttgaca tcctgtgcat cacaatctcc 660 tacaccatga tcctccgggc agtggtcagc ctctcttcag cagatgctcg acagaaggcc 720 ttcagcacct gcactgccca catctgtgcc attgttttct cctacagccc agccttcttc 780 tctttctttt cccaccgctt tgggggccac acaatccctc cctcttgcca catcattgtg 840 gccaatattt atttactcct gcctccagct atgaatcctg ttgtctatgg ggtgaaaacc 900 aagcagatac gagactgtat tgtaaagatc cttttgggtt ctaaggacat caaatcccaa 960 agcatatga 969 <210> 1150 <211> 322 <212> PRT <213> Canis familiaris <400> 1150

Met Met Leu Met Leu Asn Gln Thr Asp Leu Thr Pro Gly Ser Phe Ile 1 5 10 15 Leu Asn Gly Ile Pro Gly Leu Glu Asp Met His Met Trp Ile Ser Phe 20 25 30

Page 1294

Pro Phe Cys 35 Ser Met Tyr Ile 069269_0225_SL.TXT Val Ala Met Val Gly Asn 40 45 Cys Gly Leu Leu Tyr Leu Ile His Tyr Glu Asp Ser Leu His Arg Pro Met Tyr Tyr 50 55 60 Phe Leu Ala Met Leu Ser Leu Thr Asp Leu Phe Ile Cys Ser Ser Thr 65 70 75 80 Ile Pro Lys Ala Leu Ser Ile Leu Trp Phe His Phe Lys Glu Ile Ser 85 90 95 Phe Asp Gly Cys Leu Val Gln Met Phe Phe Val His Thr Phe Thr Gly 100 105 110 Met Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala 115 120 125 Ile Cys Tyr Pro Leu His Tyr Ser Thr Ala Leu Thr Asn Ser Val Ile 130 135 140 Ala Lys Ala Gly Leu Ser Thr Phe Leu Arg Gly Val Leu Leu Ile Ile 145 150 155 160 Pro Phe Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Ile 165 170 175 Ile Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Leu Ser Cys 180 185 190 Gly Asp Ile Lys Val Asn Val Val Tyr Gly Leu Thr Val Ala Leu Leu 195 200 205 Ile Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile 210 215 220 Leu Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala 225 230 235 240

Page 1295

Phe Ser Thr Cys Thr 245 Ala His 069269_0225_SL.TXT Ile Cys Ala Ile Val Phe 250 Ser Tyr 255 Ser Pro Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly Gly His Thr Ile 260 265 270 Pro Pro Ser Cys His Ile Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro 275 280 285 Pro Ala Met Asn Pro Val Val Tyr Gly Val Lys Thr Lys Gln Ile Arg 290 295 300 Asp Cys Ile Val Lys Ile Leu Leu Gly Ser Lys Asp Ile Lys Ser Gln 305 310 315 320

Ser Ile <210> 1151 <211> 972 <212> DNA <213> Canis familiaris <400> 1151

atgtctgcat ttctgaaagg ctctaatagc tccaaattgc aggtctctga gttcatcctg 60 ttgggattcc caggtattca cagctggcag cattggcttt ccttaccatt ggcaatgctc 120 tatgtctcag caattggtgc taacaccctc atcgtcgtca ccatctgcca agaccctgcg 180 cttcagcagc ctatgtacta tttcctaggt attctctctg tggtggacat tggcctggcc 240 accaccatca tgcccaagat tctggccatc ttctggtttg atgccaagat catcagcctc 300 cctgagtgtt ttgctcagat ttatgccatt cactgttttc ttggcatgga atctggtacc 360 ttcctctgca tggcttttga tagatatata gcaatttgtc atcctcttcg atacccctca 420 attgtcacca atggcttaat cttaaaagct actgtgttca tggtacttag aaatggcttg 480 tttgttattc cagtgcctgt tcttgcagcc cagcgtaatt attgctccag gaatgagatt 540 gagcattgtc tgtgctcaaa ccttggggtc accagcctgg cttgtgatga caggaggcca 600 aacagcatct gccaattgat tctggcatgg cttggaatgg gaagtgacct aggtcttata 660

Page 1296

069269_0225_SL.TXT

atattgtcat atactttgat tctgcgctct gtgcttaagt tgaactcggc tgaagctgca 720 tccaaagctt tgagcacttg tagctcccat ctgatcctta tcctcttctt ctacacagct 780 gttgtagttg tttcagtaac tcacctggca gagcctaagg ctcctttgat tccagttcta 840 ctcaatgtgc tgcacaatat catcccccct tccctcaacc ctatggtata tgcacttagg 900 actaaagaac ttaggacagg cttccaaaag gtatttcgtt tgagcttaga aaagaaaaca 960 aggcaccagt ga 972

<210> 1152 <211> 323 <212> PRT <213> Canis familiaris <400> 1152

Met 1 Ser Ala Phe Leu Lys Gly Ser Asn Ser Ser Lys Leu Gln Val 15 Ser 5 10 Glu Phe Ile Leu Leu Gly Phe Pro Gly Ile His Ser Trp Gln His Trp 20 25 30 Leu Ser Leu Pro Leu Ala Met Leu Tyr Val Ser Ala Ile Gly Ala Asn 35 40 45 Thr Leu Ile Val Val Thr Ile Cys Gln Asp Pro Ala Leu Gln Gln Pro 50 55 60 Met Tyr Tyr Phe Leu Gly Ile Leu Ser Val Val Asp Ile Gly Leu Ala 65 70 75 80 Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Phe Trp Phe Asp Ala Lys 85 90 95 Ile Ile Ser Leu Pro Glu Cys Phe Ala Gln Ile Tyr Ala Ile His Cys 100 105 110 Phe Leu Gly Met Glu Ser Gly Thr Phe Leu Cys Met Ala Phe Asp Arg 115 120 125 Tyr Ile Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Val Thr Asn

Page 1297

130 135 069269_0225_SL.TXT 140 Gly Leu Ile Leu Lys Ala Thr Val Phe Met Val Leu Arg Asn Gly Leu 145 150 155 160 Phe Val Ile Pro Val Pro Val Leu Ala Ala Gln Arg Asn Tyr Cys Ser 165 170 175 Arg Asn Glu Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Thr Ser 180 185 190 Leu Ala Cys Asp Asp Arg Arg Pro Asn Ser Ile Cys Gln Leu Ile Leu 195 200 205 Ala Trp Leu Gly Met Gly Ser Asp Leu Gly Leu Ile Ile Leu Ser Tyr 210 215 220 Thr Leu Ile Leu Arg Ser Val Leu Lys Leu Asn Ser Ala Glu Ala Ala 225 230 235 240 Ser Lys Ala Leu Ser Thr Cys Ser Ser His Leu Ile Leu Ile Leu Phe 245 250 255 Phe Tyr Thr Ala Val Val Val Val Ser Val Thr His Leu Ala Glu Pro 260 265 270 Lys Ala Pro Leu Ile Pro Val Leu Leu Asn Val Leu His Asn Ile Ile 275 280 285 Pro Pro Ser Leu Asn Pro Met Val Tyr Ala Leu Arg Thr Lys Glu Leu 290 295 300 Arg Thr Gly Phe Gln Lys Val Phe Arg Leu Ser Leu Glu Lys Lys Thr 305 310 315 320 Arg His Gln <210> 1153

Page 1298

069269_0225_SL.TXT tgaataaaac acatgcatgt attgtgggct ttttagccat tctgtatctt tcttcatcca gctatgtggc caaaggttgg tcacgaagcg tgtctgtagc ttgccctcct tccgggcagt ctgctcacat accgctttgg tgctcttgcc accgtgtcat aaactggacc gtggatttcc gttatacctc gctttctctt ctggtttcat taccttcaca catctgctac gcttgctact cctgtcctac caaattgtct aattggtggc ggtcagcctc ctgtgccatt gggccacaca tcccactatg aaggatcctt <211> 966 <212> DNA <213> Canis familiaris <400> 1153 atgataatat ggactggaag atggtaggga atgtattact cctaaagctc ctccagatgt gctctggacc catgtcattg ttcactttcc tgtgaccaca ggtctgatgg accatgatcc agcacctgca ttcttttccc aatatttatc cagatacgag atatag <210> 1154 <211> 321 <212> PRT <213> Canis familiaris <400> 1154

Met Ile Ile Leu Asn Lys Thr Asn Trp 1 5

ctggtctcat tcattcttaa tggagtccca 60 ttcccattct tctccatgta tattgtggcc 120 atctactatg aggattcatt gcacagacct 180 actgatattg tcatgtgctc tagtacaatt 240 ctcaaggaca ttggctttaa tgaatgtttg 300 gggatggagt ctggagtgct tatgctcatg 360 cctctgcggt actcaactat cctcaccaat 420 ttcctgagag gggtgttgct catcattccc 480 tgcagaggca atataattcc ccacacctac 540 tgtggcaatg tcaaggtcaa tgccatctat 600 tttgacatcc tgtgcatcac aatctcctac 660 tcttcagcag atgctcgaca gaaggccttc 720 gttttctcct acactccagc cttcttctct 780 atccctccct cttgccacat cattgtggcc 840 aaccctattg tttatggggt gaaaaccaag 900 tcagggtcta aggacatcaa atcccatggc 960

966

Asn Gly Val Pro Gly Leu Glu Asp Met 20 25

Thr Leu Val Ser Phe Ile Leu 10 15 His Val Trp Ile Ser Phe Pro

Page 1299

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Phe Phe Ser 35 Met Tyr Ile Val Ala Met Val Gly Asn Cys Gly Leu Leu 40 45 Tyr Leu Ile Tyr Tyr Glu Asp Ser Leu His Arg Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Met Leu Ser Leu Thr Asp Ile Val Met Cys Ser Ser Thr Ile 65 70 75 80 Pro Lys Ala Leu Cys Ile Phe Trp Phe His Leu Lys Asp Ile Gly Phe 85 90 95 Asn Glu Cys Leu Leu Gln Met Phe Phe Ile His Thr Phe Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn His Val Ile Ala 130 135 140 Lys Val Gly Leu Ala Thr Phe Leu Arg Gly Val Leu Leu Ile Ile Pro 145 150 155 160 Phe Thr Phe Leu Thr Lys Arg Leu Ser Tyr Cys Arg Gly Asn Ile Ile 165 170 175 Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Leu Ser Cys Gly 180 185 190 Asn Val Lys Val Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile 195 200 205 Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu 210 215 220 Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe 225 230 235 240

Page 1300

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Ser Thr Cys Thr Ala His Ile Cys Ala Ile Val Phe Ser Tyr Thr Pro 245 250 255 Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly Gly His Thr Ile Pro 260 265 270 Pro Ser Cys His Ile Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro Pro 275 280 285 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 Arg Val Ile Arg Ile Leu Ser Gly Ser Lys Asp Ile Lys Ser His Gly 305 310 315 320

Ile

<210> 1155 <211> 966 <212> DNA <213> Canis familiaris <400> 1155 atgataattc tgaatgaaac agatgtaaca ccagtctcat tcattcttaa tgggatccca 60 ggactggaag acatgcacat gtggatttcc ttcccattct gctccatgta tattgtggcc 120 atggtaggga attgtgggct tctatacctc atctgctatg aggactcctt gcacagatcc 180 atgtattatt ttttggccat gctttccctt accgaccttg ttatgtgctc tagtacaatc 240 cctaaagctc tctgcatctt ctggtttcat ctcaagaaaa ttggatttga agaatgccta 300 gtccagatgt tcttcatcca taccttcaca gggatggaat ctggggtgct catgctcatg 360 gccctggacc gctatgtggc catctgctac cctctgcgct atgcaaccat cctcaccaat 420 tctgtcattg caaaggttgg gcttgctact tttctgagag cagtgttgct catcattccc 480 ttgattttct tcaccaagag actaccctat tgcaagggca atataataca ccatacctat 540 tgtgaccagc tatctgtagc caagttatcc tgtggaaata tcaaggccaa tgttatctat 600

Page 1301

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ggtctgatag ctgcccttct gattggaggc tttgacatcc tgtgcatcac aatctcctac 660 accatgatcc tccgggcagt ggtcagcctc tcttcagcag atgctcgaca gaaggccttc 720 agcacctgca ctgcccacat ctgtgccatt gttttctcct acagtccagc cttcttctgc 780 ttctttttta atcgttttgg gagccgtaca atccctcctt cttgccacat cattgtggcc 840 aatatttatc tgctcctgcc tcccactatg aaccctattg tttatggagt gaaaaccaag 900 cagatacgag actgtatcat aaagatcttt tcaggttcta agaacattaa atcccacagc 960

acataa 966 <210> 1156 <211> 321 <212> PRT <213> Canis familiaris <400> 1156

Met Ile Ile Leu Asn Glu Thr Asp Val Thr Pro Val Ser Phe Ile Leu 1 5 10 15 Asn Gly Ile Pro Gly Leu Glu Asp Met His Met Trp Ile Ser Phe Pro 20 25 30 Phe Cys Ser Met Tyr Ile Val Ala Met Val Gly Asn Cys Gly Leu Leu 35 40 45 Tyr Leu Ile Cys Tyr Glu Asp Ser Leu His Arg Ser Met Tyr Tyr Phe 50 55 60 Leu Ala Met Leu Ser Leu Thr Asp Leu Val Met Cys Ser Ser Thr Ile 65 70 75 80 Pro Lys Ala Leu Cys Ile Phe Trp Phe His Leu Lys Lys Ile Gly Phe 85 90 95 Glu Glu Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125

Page 1302

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Cys Tyr Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Ser Val Ile Ala 130 135 140 Lys Val Gly Leu Ala Thr Phe Leu Arg Ala Val Leu Leu Ile Ile Pro 145 150 155 160 Leu Ile Phe Phe Thr Lys Arg Leu Pro Tyr Cys Lys Gly Asn Ile Ile 165 170 175 His His Thr Tyr Cys Asp Gln Leu Ser Val Ala Lys Leu Ser Cys Gly 180 185 190 Asn Ile Lys Ala Asn Val Ile Tyr Gly Leu Ile Ala Ala Leu Leu Ile 195 200 205 Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu 210 215 220 Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe 225 230 235 240 Ser Thr Cys Thr Ala His Ile Cys Ala Ile Val Phe Ser Tyr Ser Pro 245 250 255 Ala Phe Phe Cys Phe Phe Phe Asn Arg Phe Gly Ser Arg Thr Ile Pro 260 265 270 Pro Ser Cys His Ile Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro Pro 275 280 285 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 Cys Ile Ile Lys Ile Phe Ser Gly Ser Lys Asn Ile Lys Ser His Ser 305 310 315 320

Thr

Page 1303

069269_0225_SL.TXT <210> 1157 <211> 867 <212> DNA <213> Canis familiaris <400> 1157 atgtcaatgc tgagccaaac agtcctgacc ccagtctcat ttattcttaa tgggatccca 60 ggactggaag acatgaacat gtggattccc ttcccattat tctccattta tattgtggtt 120 atggtaggga attgtgggtt gctttacctc acctgctatg aaaattccct gcacaggtcc 180 atgtactact tctttgctat gctttcccta actgatcttg ttatgtgcac ttctacaatc 240 cctaaagctc tctgcatctt ctggttccat cttaaggaaa tcagctttaa tgaatgcctg 300 gtccagatgt tcttaatcta tgcctcaata gggatggagt gtggtatgct catactcatg 360 gccctggact gctatgcggc catctgctac cttctgcact actcaactat cctcaccaat 420 cctggcattg caaaggttgg gcttgctact tttctgagag tagtgatgct tgtcactccc 480 ttgacttaca ccatcaagag actaccctac tgtagaggga atatactata ccatacctat 540 tgtgaccaca tgtcagtagc caagttatcc tgtggaaata tcaaggtcag tgttatctac 600 ggactgatgg ttgccctcct atttggtggc tttgacatcc tgtgcatcac aatctcctac 660 actatgatca gcctctcttt agcagatgct ccacagaagg ccttcaccac ttgcactgcc 720 catatctgtt ccactgtttt cttctatagc ccagccttct tctgcttctt ttcccactgc 780 tttgggggtc acaagatccc tccttcttgc cacatcattg tggccaatat ttatctgctc 840 ttgcctccca ctatgaaccc tatgctt 867 <210> 1158 <211> 289 <212> PRT <213> Canis familiaris <400> 1158

Met Ser Met Leu Ser Gln Thr Val Leu Thr Pro Val Ser Phe Ile Leu 1 5 10 15

Asn Gly Ile Pro Gly Leu Glu Asp Met Asn Met Trp Ile Pro Phe Pro 20 25 30

Page 1304

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Leu Phe Ser 35 Ile Tyr Ile Val Val Met Val Gly Asn Cys Gly Leu Leu 40 45 Tyr Leu Thr Cys Tyr Glu Asn Ser Leu His Arg Ser Met Tyr Tyr Phe 50 55 60 Phe Ala Met Leu Ser Leu Thr Asp Leu Val Met Cys Thr Ser Thr Ile 65 70 75 80 Pro Lys Ala Leu Cys Ile Phe Trp Phe His Leu Lys Glu Ile Ser Phe 85 90 95 Asn Glu Cys Leu Val Gln Met Phe Leu Ile Tyr Ala Ser Ile Gly Met 100 105 110 Glu Cys Gly Met Leu Ile Leu Met Ala Leu Asp Cys Tyr Ala Ala Ile 115 120 125 Cys Tyr Leu Leu His Tyr Ser Thr Ile Leu Thr Asn Pro Gly Ile Ala 130 135 140 Lys Val Gly Leu Ala Thr Phe Leu Arg Val Val Met Leu Val Thr Pro 145 150 155 160 Leu Thr Tyr Thr Ile Lys Arg Leu Pro Tyr Cys Arg Gly Asn Ile Leu 165 170 175 Tyr His Thr Tyr Cys Asp His Met Ser Val Ala Lys Leu Ser Cys Gly 180 185 190 Asn Ile Lys Val Ser Val Ile Tyr Gly Leu Met Val Ala Leu Leu Phe 195 200 205 Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Ser 210 215 220 Leu Ser Leu Ala Asp Ala Pro Gln Lys Ala Phe Thr Thr Cys Thr Ala 225 230 235 240

Page 1305

069269_0225_SL.TXT His Ile Cys Ser Thr Val Phe Phe Tyr Ser Pro Ala Phe Phe Cys Phe 245 250 255

Phe Ser His Cys Phe Gly Gly His Lys Ile Pro Pro Ser Cys His Ile 260 265 270

Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro Pro Thr Met Asn Pro Met 275 280 285

Leu <210> 1159 <211> 960 <212> DNA <213> Canis familiaris <400> 1159

atgttccagg atcttagaca ttccaacatc tctaagttcc aggtctctga gttcattctg 60 atgggattcc caggcattca cacctggcaa cactggctct ccctgcccct ggcactactt 120 tacctcttag ctctcactgc caacatcctt atcctgatta tcatcaaaca agaggctaca 180 ctgcaccagc ctatgtacta tttcttgggg atcctggctg tggtagacat gggactggct 240 accaccatca tgcccaagat tttggccatc ttatggttca gtgcaaaggc catcagtctc 300 cctgagtgct ttgctcagat gtatgtcata cattgttttg tggccatgga gtcaggtatc 360 tttgtctgca tggctataga cagatatgta gccatttgcc aaccactacg ttatccatca 420 atagttactg attcttttgt cgtcaaggca actgtgttca tggcactcag aaacagtctg 480 gccaccatcc cagtgccagt gttggctgct cagaggcact actgttccaa gaaccaaatt 540 gagcattgcc tatgctctaa tcttggagtc actaggttat cctgtgatga caggacaatc 600 aacagcatct accaggttct tttggcctgg acactgatgg ggagtgacct gggtttgatt 660 ttcttatcat atgctttgat acttcactca gtgctgaagc tgaattcagc agaagctgca 720 tccaaagccc taagtacctg tacttctcac ctcattctaa tcctgttctt ctactcagtt 780 attatagtca tttccatcac ccacagtgca acaatgactc ttcctctcat cccagttctg 840 cttaatgtac tacataatgt tattcctcct gcccttaacc ctatggtata tgcactcaag 900

Page 1306

960

069269_0225_SL.TXT aacaaggacc tcaggcaggg cttctataag gttctgaatc tgtacaacaa aggtaattaa <210> 1160 <211> 319 <212> PRT <213> Canis familiaris <400> 1160

Met 1 Phe Gln Asp Leu Arg His Ser Asn Ile Ser Lys Phe Gln Val Ser 5 10 15 Glu Phe Ile Leu Met Gly Phe Pro Gly Ile His Thr Trp Gln His Trp 20 25 30 Leu Ser Leu Pro Leu Ala Leu Leu Tyr Leu Leu Ala Leu Thr Ala Asn 35 40 45 Ile Leu Ile Leu Ile Ile Ile Lys Gln Glu Ala Thr Leu His Gln Pro 50 55 60 Met Tyr Tyr Phe Leu Gly Ile Leu Ala Val Val Asp Met Gly Leu Ala 65 70 75 80 Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Leu Trp Phe Ser Ala Lys 85 90 95 Ala Ile Ser Leu Pro Glu Cys Phe Ala Gln Met Tyr Val Ile His Cys 100 105 110 Phe Val Ala Met Glu Ser Gly Ile Phe Val Cys Met Ala Ile Asp Arg 115 120 125 Tyr Val Ala Ile Cys Gln Pro Leu Arg Tyr Pro Ser Ile Val Thr Asp 130 135 140 Ser Phe Val Val Lys Ala Thr Val Phe Met Ala Leu Arg Asn Ser Leu 145 150 155 160 Ala Thr Ile Pro Val Pro Val Leu Ala Ala Gln Arg His Tyr Cys Ser 165 170 175

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Lys Asn Gln Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Thr Arg 180 185 190 Leu Ser Cys Asp Asp Arg Thr Ile Asn Ser Ile Tyr Gln Val Leu Leu 195 200 205 Ala Trp Thr Leu Met Gly Ser Asp Leu Gly Leu Ile Phe Leu Ser Tyr 210 215 220 Ala Leu Ile Leu His Ser Val Leu Lys Leu Asn Ser Ala Glu Ala Ala 225 230 235 240 Ser Lys Ala Leu Ser Thr Cys Thr Ser His Leu Ile Leu Ile Leu Phe 245 250 255 Phe Tyr Ser Val Ile Ile Val Ile Ser Ile Thr His Ser Ala Thr Met 260 265 270 Thr Leu Pro Leu Ile Pro Val Leu Leu Asn Val Leu His Asn Val Ile 275 280 285 Pro Pro Ala Leu Asn Pro Met Val Tyr Ala Leu Lys Asn Lys Asp Leu 290 295 300 Arg Gln Gly Phe Tyr Lys Val Leu Asn Leu Tyr Asn Lys Gly Asn 305 310 315

<210> 1161 <211> 960 <212> DNA <213> Canis familiaris <400> 1161 atgctccagg atcttggaca ttccaacatc tcgaagtccc aagtctctga gttcattctg ttgggattcc caggcattca cacctggcag cactggctct ccctgcccct ggcactgctt tacctcttag ctctcactgc caacatcctt atcctgatca tcatcaaaca agaggccaca ctgcaccagc ctatgtacta ttttttgggg atcctggctg tggtagacat gggactggct accaccatca tgcccaagat tttggccatc ttatggttta gtgcaaaggc catcagtctc

120

180

240

300

Page 1308

069269_0225_SL.TXT

cctgagtgct ttgctcagat gtatgtcata cattgttttg tgggcatgga gtcaggtatc 360 tttgtctgca tggctataga cagatatgta gccatttgcc aaccactacg ctatccatca 420 atagttactg attcttttgt cgtcaaggca actgtgttca tggcactcag aaacagtctg 480 gccaccatcc cagtgccaat gttggctgct cagaggcact actgttccaa gaaccaaatt 540 gagcattgcc tatgctctaa tcttggagtc actaggttat cctgtgatga caggacaatc 600 aacagcatct accagctgtt tcttgcctgg acactgatgg ggagtgacct gggtttgatt 660 ttcttatcat atgctctgat acttcactca gtgctgaagc tgaattcagc agaagctgca 720 tccaaagccc taagtacctg tacttctcac ctcattctaa tcctgttctt ctacacagtt 780 gtcattgtta tttccattac ccacagtgca acaatgactc ttcccctcat cccagttctg 840 cttaatgtac tacacaatgt tattcctcct gcccttaacc ctatggtata tgcactcaag 900 aacaaggagc tcaggcaggg cttctataag attctgaagc tggacaacaa gggtaactaa 960

<210> 1162 <211> 319 <212> PRT <213> Canis familiaris

<400> 1162 Gly His Ser Asn Ile Ser Lys Ser Gln Val Ser Met 1 Leu Gln Asp Leu 5 10 15 Glu Phe Ile Leu Leu Gly Phe Pro Gly Ile His Thr Trp Gln His Trp 20 25 30 Leu Ser Leu Pro Leu Ala Leu Leu Tyr Leu Leu Ala Leu Thr Ala Asn 35 40 45 Ile Leu Ile Leu Ile Ile Ile Lys Gln Glu Ala Thr Leu His Gln Pro 50 55 60 Met Tyr Tyr Phe Leu Gly Ile Leu Ala Val Val Asp Met Gly Leu Ala 65 70 75 80 Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Leu Trp Phe Ser Ala Lys 85 90 95

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Ala Ile Ser Leu 100 Pro Glu Cys Phe Ala Gln Met Tyr Val Ile His Cys 105 110 Phe Val Gly Met Glu Ser Gly Ile Phe Val Cys Met Ala Ile Asp Arg 115 120 125 Tyr Val Ala Ile Cys Gln Pro Leu Arg Tyr Pro Ser Ile Val Thr Asp 130 135 140 Ser Phe Val Val Lys Ala Thr Val Phe Met Ala Leu Arg Asn Ser Leu 145 150 155 160 Ala Thr Ile Pro Val Pro Met Leu Ala Ala Gln Arg His Tyr Cys Ser 165 170 175 Lys Asn Gln Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Thr Arg 180 185 190 Leu Ser Cys Asp Asp Arg Thr Ile Asn Ser Ile Tyr Gln Leu Phe Leu 195 200 205 Ala Trp Thr Leu Met Gly Ser Asp Leu Gly Leu Ile Phe Leu Ser Tyr 210 215 220 Ala Leu Ile Leu His Ser Val Leu Lys Leu Asn Ser Ala Glu Ala Ala 225 230 235 240 Ser Lys Ala Leu Ser Thr Cys Thr Ser His Leu Ile Leu Ile Leu Phe 245 250 255 Phe Tyr Thr Val Val Ile Val Ile Ser Ile Thr His Ser Ala Thr Met 260 265 270 Thr Leu Pro Leu Ile Pro Val Leu Leu Asn Val Leu His Asn Val Ile 275 280 285 Pro Pro Ala Leu Asn Pro Met Val Tyr Ala Leu Lys Asn Lys Glu Leu 290 295 300

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Arg Gln Gly Phe Tyr Lys Ile Leu Lys Leu Asp Asn Lys Gly Asn 305 310 315 <210> 1163 <211> 960 <212> DNA <213> Canis familiaris <400> 1163

atgctccagg atcttggaca ttccaacatc tcgaagtccc aagtctctga gttcattctg 60 atgggattcc caggcattca cacctggcag cactggctct ccctgcccct ggcactactt 120 tacctcttag ctctcactgc caacatcctt atcctgatca tcatcaaaca agaggccaca 180 ctgcaccagc ctatgtacta ttttttgggg atcctggctg tggtagacat gggactggct 240 accaccatca tgcccaagat tttggccatc ttatggttca gtgcaaaggc cattggtctc 300 cctgaatgct ttgctcagat gtatgtcata cattgttttg tactcatgga gtcaggtatc 360 tttgtctgca tggctataga cagatatgta gccatttgcc aaccactacg ctatccatca 420 atagttactg attcttttgt cgccaaggca actgtgttta tggcactcag aaacagtctg 480 gctaccatcc cagtgccagt gttggccgct gagaggcact actgttccaa gaaccaaatt 540 gagcattgcc tatgctctaa tcttggagtc actaggttat cctgtgatga cagaaccatc 600 aacagcatct accagctatt tcttgcctgg acactgatgg ggagtgacct gggtttgatt 660 tttttatcat atgctttgat actccactca gtgctgaagc tgaattcagc agaagctgca 720 tccaaagccc taagtacctg tacttcccat ctcatcctaa ttttattctt ttacactgtc 780 attgttgtca tttctattac ccacagtgca acaatgactc ttcccctcat cccagttctg 840 cttaatgtac tacacaatgt tattcctcct gccctcaatc ccatagtgta tgcattcaaa 900 aacaaggagc tcaggcaggg cttctataag gctcttaagc tgaatatcaa gggcaactaa 960

<210> 1164 <211> 319 <212> PRT <213> Canis familiaris <400> 1164

Met Leu Gln Asp Leu Gly His Ser Asn Ile Ser Lys Ser Gln Val Ser Page 1311

069269_0225_SL.TXT

1 5 10 15 Glu Phe Ile Leu Met Gly Phe Pro Gly Ile His Thr Trp Gln His Trp 20 25 30 Leu Ser Leu Pro Leu Ala Leu Leu Tyr Leu Leu Ala Leu Thr Ala Asn 35 40 45 Ile Leu Ile Leu Ile Ile Ile Lys Gln Glu Ala Thr Leu His Gln Pro 50 55 60 Met Tyr Tyr Phe Leu Gly Ile Leu Ala Val Val Asp Met Gly Leu Ala 65 70 75 80 Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Leu Trp Phe Ser Ala Lys 85 90 95 Ala Ile Gly Leu Pro Glu Cys Phe Ala Gln Met Tyr Val Ile His Cys 100 105 110 Phe Val Leu Met Glu Ser Gly Ile Phe Val Cys Met Ala Ile Asp Arg 115 120 125 Tyr Val Ala Ile Cys Gln Pro Leu Arg Tyr Pro Ser Ile Val Thr Asp 130 135 140 Ser Phe Val Ala Lys Ala Thr Val Phe Met Ala Leu Arg Asn Ser Leu 145 150 155 160 Ala Thr Ile Pro Val Pro Val Leu Ala Ala Glu Arg His Tyr Cys Ser 165 170 175 Lys Asn Gln Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Thr Arg 180 185 190 Leu Ser Cys Asp Asp Arg Thr Ile Asn Ser Ile Tyr Gln Leu Phe Leu 195 200 205 Ala Trp Thr Leu Met Gly Ser Asp Leu Gly Leu Ile Phe Leu Ser Tyr

Page 1312

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210 215 220

Ala 225 Leu Ile Leu His Ser Val Leu Lys 230 Leu Asn Ser Ala Glu Ala Ala 235 240 Ser Lys Ala Leu Ser Thr Cys Thr Ser His Leu Ile Leu Ile Leu Phe 245 250 255 Phe Tyr Thr Val Ile Val Val Ile Ser Ile Thr His Ser Ala Thr Met 260 265 270 Thr Leu Pro Leu Ile Pro Val Leu Leu Asn Val Leu His Asn Val Ile 275 280 285 Pro Pro Ala Leu Asn Pro Ile Val Tyr Ala Phe Lys Asn Lys Glu Leu 290 295 300 Arg Gln Gly Phe Tyr Lys Ala Leu Lys Leu Asn Ile Lys Gly Asn 305 310 315

<210> 1165 <211> 963 <212> DNA <213> Canis familiaris <400> 1165

atgtcattcc taaatggtac ctacctaact ccagcttcat tcatcttaaa tggcatccct 60 gggctggaag aagtacattt gtggatctcc ttgcccttgt gcaccatgta cagcattgcc 120 atcacaggga actttggcct catgtacctc atttactctg aagagacctt gcacagacct 180 atgtacatct tcctagctct tctttccttc acagatgtgc tcatgtgcac cagcactctt 240 cccaacacac tctgcatatt gtggttcaac ctcaaggaga ttgattttaa ggcctgcttg 300 gcccaaatgt tctttgtgca cacttttaca gggatggagt ctggggtgct catgctcatg 360 gctctggacc gctatgtggc catctgctac cccctgcgct atgctactat cctcactaat 420 tcagtcattg ccaaggctgg actcctcact tttcttagag gtgtaatgct tgttatccct 480 ttcacttacc ttaccaagcg cctgccatac tgcaggggca atgtcatacc gcacacctac 540 tgtgaccaca tgtctgtggc caaggtatcc tgtggcaatg ttaggatcaa tgccatctat 600

Page 1313

069269_0225_SL.TXT

ggtttaatgg ttgcccttct gattgggggc tttgatatct tatgcatcac aatttcctac 660 acaatgatcc ttcgagcagt tgtgagtctc tcatcagcag atgctcagca gaaggccttc 720 agcacatgta ctgcccacat ctgtgccatt gtcatcacct atgtcccagc cttcttcacc 780 ttctttaccc accggtttgg gggacacacc attcctccac acatacacat tattatggct 840 aatctctatc tgctcatgcc tcccacaatg aaccctattg tgtatggggt gaaaaccaag 900 cagatacgag aaagtgtcat tagattcttg cttaagggaa agggcaattc tcatagcatt 960

taa 963 <210> 1166 <211> 320 <212> PRT <213> Canis familiaris <400> 1166

Met Ser Phe Leu Asn Gly Thr Tyr Leu Thr Pro Ala Ser Phe Ile Leu 1 5 10 15 Asn Gly Ile Pro Gly Leu Glu Glu Val His Leu Trp Ile Ser Leu Pro 20 25 30 Leu Cys Thr Met Tyr Ser Ile Ala Ile Thr Gly Asn Phe Gly Leu Met 35 40 45 Tyr Leu Ile Tyr Ser Glu Glu Thr Leu His Arg Pro Met Tyr Ile Phe 50 55 60 Leu Ala Leu Leu Ser Phe Thr Asp Val Leu Met Cys Thr Ser Thr Leu 65 70 75 80 Pro Asn Thr Leu Cys Ile Leu Trp Phe Asn Leu Lys Glu Ile Asp Phe 85 90 95 Lys Ala Cys Leu Ala Gln Met Phe Phe Val His Thr Phe Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125

Page 1314

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Cys Tyr Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Ser Val Ile Ala 130 135 140 Lys Ala Gly Leu Leu Thr Phe Leu Arg Gly Val Met Leu Val Ile Pro 145 150 155 160 Phe Thr Tyr Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Val Ile 165 170 175 Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Val Ser Cys Gly 180 185 190 Asn Val Arg Ile Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile 195 200 205 Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu 210 215 220 Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Gln Gln Lys Ala Phe 225 230 235 240 Ser Thr Cys Thr Ala His Ile Cys Ala Ile Val Ile Thr Tyr Val Pro 245 250 255 Ala Phe Phe Thr Phe Phe Thr His Arg Phe Gly Gly His Thr Ile Pro 260 265 270 Pro His Ile His Ile Ile Met Ala Asn Leu Tyr Leu Leu Met Pro Pro 275 280 285 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu 290 295 300 Ser Val Ile Arg Phe Leu Leu Lys Gly Lys Gly Asn Ser His Ser Ile 305 310 315 320

<210> 1167 <211> 963

Page 1315

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 1167

atgctccttt cccactccta tgtcaacatc tccttcttcc agccacatgc cttcctgatg 60 attggcatcc cagggctgga ggctgttcat ggatggatct ccatcccctt ctctttcatg 120 tacactgtgg ccctcactgg aaactgcttg attctcttgg ctgtgaggag aactcccagc 180 ttgcaccaac ccatgtacta cttcctgtcc atgctggccc tcactgatgt gggccttact 240 ctgtccacac tgcccaccac cctggctgtg ctctggttta attatcggca cataggcttc 300 aatgcttgct tggtccagat gttcttcctc cactccttct ctgtggtgga gtcatcagtg 360 ctcctggcca tgtcatttga ccgctttgtg gccatctcta accctcttca ctatgcagct 420 atcctcacca ataatgtcat tattaggatt gggctggcca ttgtggcccg tgctaccctg 480 tctctcttcc cagtgccctt ccttcttaaa cgtctgaact tctgccctga caagattctc 540 ttgtcccact cattctgttt ccatcctgat gtgatgagaa gagcctgtgc tgacatcacc 600 ataaacattc actatgggct ctatgtggta ctgtccactg gtggcataga ttctctgttc 660 atcatcctct cctatgttct catcctacac acagtcctag gactggcctc cccccgggag 720 cgcatccggg ccttcaacac ctgtgtttct catatcctgg ctgtctttgt cttcttcatc 780 ccaggcatta ctatgtccat gatccaccgt tttgggaggc acctacccac tgttgtacat 840 gccctggttg cctatgtgta cctggtggtg ccccctgtgc tcaaccccat catctacagt 900 gtgaaatcca agcccatcag ggaggccatg attaggatgc taaagaggaa aggccaaggt 960

tga 963 <210> 1168 <211> 320 <212> PRT <213> Canis familiaris <400> 1168

Met Leu Leu Ser His Ser Tyr Val Asn Ile Ser Phe Phe Gln Pro His 1 5 10 15

Ala Phe Leu Met Ile Gly Ile Pro Gly Leu Glu Ala Val His Gly Trp 20 25 30

Page 1316

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Ile Ser Ile 35 Pro Phe Ser Phe Met Tyr Thr Val Ala Leu Thr Gly Asn 40 45 Cys Leu Ile Leu Leu Ala Val Arg Arg Thr Pro Ser Leu His Gln Pro 50 55 60 Met Tyr Tyr Phe Leu Ser Met Leu Ala Leu Thr Asp Val Gly Leu Thr 65 70 75 80 Leu Ser Thr Leu Pro Thr Thr Leu Ala Val Leu Trp Phe Asn Tyr Arg 85 90 95 His Ile Gly Phe Asn Ala Cys Leu Val Gln Met Phe Phe Leu His Ser 100 105 110 Phe Ser Val Val Glu Ser Ser Val Leu Leu Ala Met Ser Phe Asp Arg 115 120 125 Phe Val Ala Ile Ser Asn Pro Leu His Tyr Ala Ala Ile Leu Thr Asn 130 135 140 Asn Val Ile Ile Arg Ile Gly Leu Ala Ile Val Ala Arg Ala Thr Leu 145 150 155 160 Ser Leu Phe Pro Val Pro Phe Leu Leu Lys Arg Leu Asn Phe Cys Pro 165 170 175 Asp Lys Ile Leu Leu Ser His Ser Phe Cys Phe His Pro Asp Val Met 180 185 190 Arg Arg Ala Cys Ala Asp Ile Thr Ile Asn Ile His Tyr Gly Leu Tyr 195 200 205 Val Val Leu Ser Thr Gly Gly Ile Asp Ser Leu Phe Ile Ile Leu Ser 210 215 220 Tyr Val Leu Ile Leu His Thr Val Leu Gly Leu Ala Ser Pro Arg Glu 225 230 235 240

Page 1317

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Arg Ile Arg Ala Phe Asn Thr Cys Val Ser His Ile Leu Ala Val Phe 245 250 255 Val Phe Phe Ile Pro Gly Ile Thr Met Ser Met Ile His Arg Phe Gly 260 265 270 Arg His Leu Pro Thr Val Val His Ala Leu Val Ala Tyr Val Tyr Leu 275 280 285 Val Val Pro Pro Val Leu Asn Pro Ile Ile Tyr Ser Val Lys Ser Lys 290 295 300 Pro Ile Arg Glu Ala Met Ile Arg Met Leu Lys Arg Lys Gly Gln Gly 305 310 315 320 <210> 1169 <211> 960 <212> DNA <213> Canis familiaris

<400> 1169

atgcatggag ccaacagctc cagcctgaca ccaagatact tcatccttaa tgggattcct 60 gaactagaag ccttacacac ttggatctcc ctgccattct gcttcatgta catcatcact 120 gtcctgggga actgtgggct catctacctc atcagccatg aggaggccct gcatcggccc 180 atgtattact tcctagcttt actgtccctt acagatgtta gtgtgtgcac ttcatttgtt 240 cctaatatgt tatgtatctt ttggttcaac ctcaaagaga ttgactttga tgcctgcctt 300 gtgcagatgt ttttcatcca catgctgacc ggtatggagt ctggcgtgct catgcttatg 360 gccctggacc gctatgtggc catttgctac cctctacgtt attctaccat cctcaccaac 420 atggtaatta ccaaagttgg gtttgccacc ttcagtcgaa gtgtgttgct catgatccca 480 ttcactttcc tgattaggcg tcttccctac tgcaagggca acctcattca ccacacctac 540 tgtgaccata tgtctgtagc caaactgtcc tgtggcaaca tcaagattaa tgccatctat 600 ggtctcatag ctgccatact gataggagga tttgatatgt tctgtatctt catgtcttac 660 accatgatta tccgtgctgt agtgaatctg ccatcttcag atgctcggca caaagccttc 720 agcacctgta catcacacat atgtgctatt gtcatcacct atgtcccagc cttcttcaac 780

Page 1318

069269_0225_SL.TXT ttttttactc atcgttttgg gggacgcacc atacctcacc atgttcacat ttttatagcc aatctctacc tgttgttgcc tcccaccttg aatccaattg tctatggagt gaaaaccaag cagatccgtg aaggagtgat caaattgttt ttagagagaa atattttgag gatgagctaa

840

900

960 <210> 1170 <211> 319 <212> PRT <213> Canis familiaris

<400> 1170 Ser Ser Ser Leu Thr Pro Arg Tyr Phe Ile Leu Met His 1 Gly Ala Asn 5 10 15 Asn Gly Ile Pro Glu Leu Glu Ala Leu His Thr Trp Ile Ser Leu Pro 20 25 30 Phe Cys Phe Met Tyr Ile Ile Thr Val Leu Gly Asn Cys Gly Leu Ile 35 40 45 Tyr Leu Ile Ser His Glu Glu Ala Leu His Arg Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Leu Leu Ser Leu Thr Asp Val Ser Val Cys Thr Ser Phe Val 65 70 75 80 Pro Asn Met Leu Cys Ile Phe Trp Phe Asn Leu Lys Glu Ile Asp Phe 85 90 95 Asp Ala Cys Leu Val Gln Met Phe Phe Ile His Met Leu Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn Met Val Ile Thr 130 135 140 Lys Val Gly Phe Ala Thr Phe Ser Arg Ser Val Leu Leu Met Ile Pro 145 150 155 160

Page 1319

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Phe Thr Phe Leu Ile Arg Arg Leu Pro Tyr Cys Lys Gly Asn Leu Ile 165 170 175 His His Thr Tyr Cys Asp His Met Ser Val Ala Lys Leu Ser Cys Gly 180 185 190 Asn Ile Lys Ile Asn Ala Ile Tyr Gly Leu Ile Ala Ala Ile Leu Ile 195 200 205 Gly Gly Phe Asp Met Phe Cys Ile Phe Met Ser Tyr Thr Met Ile Ile 210 215 220 Arg Ala Val Val Asn Leu Pro Ser Ser Asp Ala Arg His Lys Ala Phe 225 230 235 240 Ser Thr Cys Thr Ser His Ile Cys Ala Ile Val Ile Thr Tyr Val Pro 245 250 255 Ala Phe Phe Asn Phe Phe Thr His Arg Phe Gly Gly Arg Thr Ile Pro 260 265 270 His His Val His Ile Phe Ile Ala Asn Leu Tyr Leu Leu Leu Pro Pro 275 280 285 Thr Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu 290 295 300 Gly Val Ile Lys Leu Phe Leu Glu Arg Asn Ile Leu Arg Met Ser

305 310 315 <210> 1171 <211> 963 <212> DNA <213> Canis familiaris <400> 1171 atgtgtgggg aaaacagctc cagcctggcc ccaggattct ttgtcttgaa tggtatccct gggctggaag ctgcacacac ctggatcgcc ctgccattct gcttcatgta catcatcact

120

Page 1320

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gtcctgggga actgtgggct catctacctc atcagccatg aggaggccct gcatcagccc 180 atgtactact tcctggccct gctctccttc acagatgtca ccctgtgcac caccacggta 240 cccaatatgc tgtgcatatt ctggttcaac ctcaaggaga ttcactttaa tgcctgcctg 300 gctcagatgt tttttgtcca tatgctgact gggatggagt ctggggtgct catgctcatg 360 gccctggacc gctacgtggc catctgccac cccttacgtt attccaccat cctcaccaac 420 cctgtcatca ccaaggcagg tcttgccacg ttcctgaggg gtgtgctgct catcctccca 480 ttcacattcc tcaccaagcg tctgccctat tgccgaagca actttattcc ccatacctac 540 tgtgaccaca tgtctgtggc caaggtgtcc tgtggcaatt tcaaggtcaa tgctatctat 600 ggtctcttgg cagccctcct gattggaggc tttgatatgt tctgtatttc tgtgtcttac 660 actatgatac tgagggcagt agtgagcctg tcatctgcag atgctcgtca caaagccttc 720 agcacctgca catcccacat atgtgctatt gttatcactt atgttccagc gctgttcacc 780 atttttactc atcgttttgg gggacaaagc attccccacc atgtgcatat tcttattgct 840 aatctctatt tgatgttgcc tcctactctg aatcccattg tttacggagt caagaccaag 900 cagatccagg aaggagtcat caagttattt tttaaagaga aagatgtctt agttatgaaa 960

tag 963 <210> 1172 <211> 320 <212> PRT <213> Canis familiaris <400> 1172

Met Cys Gly Glu Asn Ser Ser Ser Leu Ala Pro Gly Phe Phe Val Leu 1 5 10 15 Asn Gly Ile Pro Gly Leu Glu Ala Ala His Thr Trp Ile Ala Leu Pro 20 25 30 Phe Cys Phe Met Tyr Ile Ile Thr Val Leu Gly Asn Cys Gly Leu Ile 35 40 45 Tyr Leu Ile Ser His Glu Glu Ala Leu His Gln Pro Met Tyr Tyr Phe 50 55 60

Page 1321

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Leu 65 Ala Leu Leu Ser Phe Thr Asp Val Thr Leu Cys Thr Thr Thr Val 70 75 80 Pro Asn Met Leu Cys Ile Phe Trp Phe Asn Leu Lys Glu Ile His Phe 85 90 95 Asn Ala Cys Leu Ala Gln Met Phe Phe Val His Met Leu Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn Pro Val Ile Thr 130 135 140 Lys Ala Gly Leu Ala Thr Phe Leu Arg Gly Val Leu Leu Ile Leu Pro 145 150 155 160 Phe Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Arg Ser Asn Phe Ile 165 170 175 Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Val Ser Cys Gly 180 185 190 Asn Phe Lys Val Asn Ala Ile Tyr Gly Leu Leu Ala Ala Leu Leu Ile 195 200 205 Gly Gly Phe Asp Met Phe Cys Ile Ser Val Ser Tyr Thr Met Ile Leu 210 215 220 Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg His Lys Ala Phe 225 230 235 240 Ser Thr Cys Thr Ser His Ile Cys Ala Ile Val Ile Thr Tyr Val Pro 245 250 255 Ala Leu Phe Thr Ile Phe Thr His Arg Phe Gly Gly Gln Ser Ile Pro 260 265 270

Page 1322

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His His Val 275 His Ile Leu Ile Ala Asn Leu Tyr Leu Met Leu Pro Pro 280 285 Thr Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Gln Glu 290 295 300 Gly Val Ile Lys Leu Phe Phe Lys Glu Lys Asp Val Leu Val Met Lys 305 310 315 320

<210> 1173 <211> 972 <212> DNA <213> Canis familiaris <400> 1173

atgtgtgggg aaaacagctc cagcctggcc ccaggattct ttgtcttgaa tggtatccct 60 gggctggaag ctgcacacac ctggatcacc ctgccattct gcttcatgta catcaccgct 120 gtcctgggga actgtgggct catctacctc atcagccatg aggaggccct gcatcggccc 180 atgtactact tcctggccct gctctccttc acagatgtca ccctgtgcac caccacggta 240 cccaatatgc tgtgcatatt ctggttcaac ctcaaggaga ttcactttaa tgcctgcctg 300 gctcagatgt tttttgtcca tatgctgact gggatggagt ctggggtgct catgctcatg 360 gccctggacc gctacgtggc catctgccac cccttacgtt attccaccat cctcaccaac 420 cctgtcatca ccaaggcagg tcttgccacg ttcctgaggg gtgtgctgct catcctccca 480 ttcacattcc tcaccaagcg tctgccctat tgccgaagca actttattcc ccatacctac 540 tgtgaccaca tgtctgtggc caaggtgtcc tgtggcaatt tcaaggtcaa tgctatctat 600 ggcttaatgg ttgctctcct tattggtgtg tttgatatat gctgtatttc tgtgtcttac 660 actatgatat tgagggcagt agtgagcctg tcatctgcag atgctcgtca caaagccttc 720 agcacctgca catcccacat atgtgctatt gtcatcactt atgttccagc ttttttcaca 780 ttttttgccc accgttttgg aggacacaat atcccccacc acatacacgt cattgtagcc 840 aacatttact tgctactgcc tcctacaatg aacccaattg tttatggagt taagaccaag 900 cagatccggg aaggtgtgat caagttttta gttggagata ggttgtcttt acccaagaca 960 aataaatcat aa 972

Page 1323

069269_0225_SL.TXT <210> 1174 <211> 323 <212> PRT <213> Canis familiaris

<400> 1174 Met 1 Cys Gly Glu Asn 5 Ser Ser Ser Leu Ala 10 Pro Gly Phe Phe Val 15 Leu Asn Gly Ile Pro Gly Leu Glu Ala Ala His Thr Trp Ile Thr Leu Pro 20 25 30 Phe Cys Phe Met Tyr Ile Thr Ala Val Leu Gly Asn Cys Gly Leu Ile 35 40 45 Tyr Leu Ile Ser His Glu Glu Ala Leu His Arg Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Leu Leu Ser Phe Thr Asp Val Thr Leu Cys Thr Thr Thr Val 65 70 75 80 Pro Asn Met Leu Cys Ile Phe Trp Phe Asn Leu Lys Glu Ile His Phe 85 90 95 Asn Ala Cys Leu Ala Gln Met Phe Phe Val His Met Leu Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn Pro Val Ile Thr 130 135 140 Lys Ala Gly Leu Ala Thr Phe Leu Arg Gly Val Leu Leu Ile Leu Pro 145 150 155 160 Phe Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Arg Ser Asn Phe Ile 165 170 175

Page 1324

Pro His Thr Tyr 180 Cys Asp His 069269_0225_SL.TXT Met Ser Val Ala Lys Val 185 Ser 190 Cys Gly Asn Phe Lys Val Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile 195 200 205 Gly Val Phe Asp Ile Cys Cys Ile Ser Val Ser Tyr Thr Met Ile Leu 210 215 220 Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg His Lys Ala Phe 225 230 235 240 Ser Thr Cys Thr Ser His Ile Cys Ala Ile Val Ile Thr Tyr Val Pro 245 250 255 Ala Phe Phe Thr Phe Phe Ala His Arg Phe Gly Gly His Asn Ile Pro 260 265 270 His His Ile His Val Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro Pro 275 280 285 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu 290 295 300 Gly Val Ile Lys Phe Leu Val Gly Asp Arg Leu Ser Leu Pro Lys Thr 305 310 315 320

Asn Lys Ser <210> 1175 <211> 438 <212> DNA <213> Canis familiaris <400> 1175 tttcctcttc gctatgccac tatcctcacc aattctatcg ttgccaaggc caagtttctc accttccctc taggtgtgat acttgccatt ccatttacat tactcaccaa acatcttccc tatcgcaagg gtaatataat ttcccatacc cactgtgatc acatgactgt ggccaagttg

120

180

Page 1325

069269_0225_SL.TXT tcctgtggca atatcaaggt caatgccatc tatagtctga tggttgccct tctgattggg gactttgaca tcctgtgcat cacagtctcc tactccatga ttctctgggc agtggtcagc ctctcctcag cagatgctca gcagaaggcc tttagcacct gaactgccca aatctgtgct atagtcatca cctatgtctc agccttcctt actttttttt actcaccatt tagggggtca tacagccctc cacagctt

240

300

360

420

438 <210> 1176 <211> 113 <212> PRT <213> Canis familiaris <400> 1176

Phe Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Ser Ile Val Ala Lys 1 5 10 15 Ala Lys Phe Leu Thr Phe Pro Leu Gly Val Ile Leu Ala Ile Pro Phe 20 25 30 Thr Leu Leu Thr Lys His Leu Pro Tyr Arg Lys Gly Asn Ile Ile Ser 35 40 45 His Thr His Cys Asp His Met Thr Val Ala Lys Leu Ser Cys Gly Asn 50 55 60 Ile Lys Val Asn Ala Ile Tyr Ser Leu Met Val Ala Leu Leu Ile Gly 65 70 75 80 Asp Phe Asp Ile Leu Cys Ile Thr Val Ser Tyr Ser Met Ile Leu Trp 85 90 95 Ala Val Val Ser Leu Ser Ser Ala Asp Ala Gln Gln Lys Ala Phe Ser 100 105 110

Thr <210> 1177 <211> 939 <212> DNA

Page 1326

069269_0225_SL.TXT <213> Canis familiaris <400> 1177

atgtccccct caaatgatac caagtctcat ccctcctatt tcctcctact gggagttcca 60 ggccttgaag agatgcacat ctggattggg tttccttttt gttttgtgta tttgattgcc 120 cttgtgggaa acatcattat cctgtttgtg atcaagaatg aacacagtct tcatcagcct 180 atgttttact tcttggccat gttagcctcc attgatgtgg gtctatcgac atccactatc 240 cccaaaatgt tgggcatatt ctggtttaat ttaaaagaga ttagttttga tggctgtgtc 300 acccaaatgt tctttattca tatattcact gccatggaga ctgttgcatt ggtggccatg 360 gcctttgacc gccatgttac catctgcaat cctctgagat acagcctgat tctcacgaac 420 aggatgattt gtctcatcct tgttgtggtg tttggtgtca atttcatttt ggttatccct 480 ctggtgtttc ttattttgag gctttccttc tgtggacacc atataatccc acatacatac 540 tgtgagcaca tgggaattgc tcggctggcc tgtgccagta taaaagtaaa tatgatattt 600 ggattatttc ttgtatcagt ggtgtttgtt gatgttgttc tgattgtcat ttcctatgtg 660 aaaatactct gagctgtctt ctgcctttct tctcaggatg ccagactcaa ggtacttaat 720 acatgtggct cccatatctg tattattcta gccttcttca ctccagcttt tttctctgtc 780 ttgacccatc gttttggcag ggatgttccc atatacatat acattcacat tctcctggcc 840 aatctatatg ttgttgttcc acctgccctc aatcctctca tctatggagt aaggacaaag 900 caaattcggg aaagggtttc aagtatcttt tggaaaaaa 939

<210> 1178 <211> 223 <212> PRT <213> Canis familiaris

<400> 1178 Asp Thr Lys Ser His Pro Ser Tyr Phe Leu Leu Met 1 Ser Pro Ser Asn 5 10 15 Leu Gly Val Pro Gly Leu Glu Glu Met His Ile Trp Ile Gly Phe Pro 20 25 30 Phe Cys Phe Val Tyr Leu Ile Ala Leu Val Gly Asn Ile Ile Ile Leu 35 40 45

Page 1327

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Phe Val Ile 50 Lys Asn Glu His Ser Leu His Gln Pro Met Phe Tyr Phe 55 60 Leu Ala Met Leu Ala Ser Ile Asp Val Gly Leu Ser Thr Ser Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Lys Glu Ile Ser Phe 85 90 95 Asp Gly Cys Val Thr Gln Met Phe Phe Ile His Ile Phe Thr Ala Met 100 105 110 Glu Thr Val Ala Leu Val Ala Met Ala Phe Asp Arg His Val Thr Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ser Leu Ile Leu Thr Asn Arg Met Ile Cys 130 135 140 Leu Ile Leu Val Val Val Phe Gly Val Asn Phe Ile Leu Val Ile Pro 145 150 155 160 Leu Val Phe Leu Ile Leu Arg Leu Ser Phe Cys Gly His His Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala 180 185 190 Ser Ile Lys Val Asn Met Ile Phe Gly Leu Phe Leu Val Ser Val Val 195 200 205 Phe Val Asp Val Val Leu Ile Val Ile Ser Tyr Val Lys Ile Leu 210 215 220

<210> 1179 <211> 942 <212> DNA <213> Canis familiaris <400> 1179

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atgtctccag ccaatacatc atgtattcac ccctcatcct tcctgctgtt gggaatccca 60 ggactggaaa atatgcagtt ctggcttggt atcccatttg gtacggtgta tctgattgcc 120 ctcctgggga atgtcatcat cctttttgtg attcagactg agcacagcct tcaccaaccc 180 atgttctact tattggccat gttggctctc actgacctgg gcctctccac tgccaccatt 240 cccaaaatgc tgagcatttt ctggttcggc ttcagtgaga ttgcctttgg gggatgctta 300 gctcaaatgt tcttcataca cctgtttaca ggctttgaaa cattcatgct tgtagccatg 360 gcttttgatc gctatgttgc catttgccac cctcttcgat acaacacaat cctcaccaac 420 agaactattt gtattattgc tggagtagga atgctgaaaa attttgcttt ggtgcttcca 480 cttgtgtttc tccttctaag gctttcattc tgtgggaata atattatacc tcattcctat 540 tgtgagcaca tgggcattgc ccgcctggcc tgtgtcagca taaaggtcaa tgtattattt 600 ggattaatcc tcatctctat gatacttttg gatgttgttt tgattgctct ctcctatgtg 660 aagattctac atgctgtctt cagactccct tcctgggagg ctaggctcaa agctcttaat 720 acctgtggtt cccatggatg tgtcatctta gcttttttca ctccagcatt tttctccttt 780 atgactcatc gatttggcca caatattcca cgttacatcc acatcctctt ggctaatttg 840 tatgtaatca tccctcctgc tcttaacccc attatttatg gggtgagaac caaacagatc 900 cgagagcagg tagtgatgat cttccttttt aaggaagttt ga 942

<210> 1180 <211> 313 <212> PRT <213> Canis familiaris

<400> 1180 Met 1 Ser Pro Ala Asn Thr Ser Cys Ile His Pro Ser Ser Phe Leu Leu 5 10 15 Leu Gly Ile Pro Gly Leu Glu Asn Met Gln Phe Trp Leu Gly Ile Pro 20 25 30 Phe Gly Thr Val Tyr Leu Ile Ala Leu Leu Gly Asn Val Ile Ile Leu 35 40 45 Phe Val Ile Gln Thr Glu His Ser Leu His Gln Pro Met Phe Tyr Leu Page 1329

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50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Ser Ile Phe Trp Phe Gly Phe Ser Glu Ile Ala Phe 85 90 95 Gly Gly Cys Leu Ala Gln Met Phe Phe Ile His Leu Phe Thr Gly Phe 100 105 110 Glu Thr Phe Met Leu Val Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg Tyr Asn Thr Ile Leu Thr Asn Arg Thr Ile Cys 130 135 140 Ile Ile Ala Gly Val Gly Met Leu Lys Asn Phe Ala Leu Val Leu Pro 145 150 155 160 Leu Val Phe Leu Leu Leu Arg Leu Ser Phe Cys Gly Asn Asn Ile Ile 165 170 175 Pro His Ser Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Val 180 185 190 Ser Ile Lys Val Asn Val Leu Phe Gly Leu Ile Leu Ile Ser Met Ile 195 200 205 Leu Leu Asp Val Val Leu Ile Ala Leu Ser Tyr Val Lys Ile Leu His 210 215 220 Ala Val Phe Arg Leu Pro Ser Trp Glu Ala Arg Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Gly Ser His Gly Cys Val Ile Leu Ala Phe Phe Thr Pro Ala 245 250 255 Phe Phe Ser Phe Met Thr His Arg Phe Gly His Asn Ile Pro Arg Tyr

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069269_0225_SL.TXT 265 270

Ile His Ile Leu Leu Ala Asn Leu Tyr Val Ile Ile Pro Pro Ala Leu 275 280 285 Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Gln Val 290 295 300 Val Met Ile Phe Leu Phe Lys Glu Val

305 310 <210> 1181 <211> 939 <212> DNA <213> Canis familiaris <400> 1181

atgtccactc ttaatgatac ccaatttcac ccttcttcat tcctactctt gggtatacca 60 gggctagaag atgtgcattt ctggatcgga tttccctttt tctttgtgta tcttgttgca 120 ctcctgggga atactgctgt cctatttgtg atcctgactg agcataatct ccatgagccc 180 atgtactact ttctggccat attggactgc attgacctgg gcttatccac agccaccatc 240 cccaaaatgt tgggcatctt ctggttcagc ctcagagata tatcttttga aagctgtctt 300 tctcagatgt tcttcatcca tttcttcact gccatggaga gcattgtgtt ggtggccatg 360 gcctttgacc gctacattgc catttgtaaa cctcttcggt acaccatgat cctcaccaac 420 agaatcatca tcatcattgc aggcattgct attctgagga gtctttgcat ggtgatccca 480 ctggtgtttc tcctcctgag gctgcccttt tgtgggcacc acatcatccc tcatacctat 540 tgtgaacaca tgggcattgc ccgtctggct tgtgccagca tcaaagtcaa cataatattt 600 ggtcttgggg atatgtctat tttattattg gatgtgcttc ttattactct ttcctatgtc 660 aggatcctcc atgctgtctt ctgcttgccc tccaaggagg ctcgactcaa agctctcaac 720 acctgtggct cccacattgg tgttatttca gcctttttca ctccagcatt tttctctttc 780 ttgacacatc gttttggcca caacatcccc cagtatatcc acattttttt agccaatcta 840 tacatcgttg ttccaccagc tctcaatcct gcaatctacg gggtcaggac caagcagatt 900 agagagcggg ttttgaggat tttttttaaa gacatttaa 939

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069269_0225_SL.TXT <210> 1182 <211> 312 <212> PRT <213> Canis familiaris

<400> 1182 Met 1 Ser Thr Leu Asn 5 Asp Thr Gln Phe His Pro Ser Ser Phe Leu Leu 10 15 Leu Gly Ile Pro Gly Leu Glu Asp Val His Phe Trp Ile Gly Phe Pro 20 25 30 Phe Phe Phe Val Tyr Leu Val Ala Leu Leu Gly Asn Thr Ala Val Leu 35 40 45 Phe Val Ile Leu Thr Glu His Asn Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Ile Leu Asp Cys Ile Asp Leu Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Ser Leu Arg Asp Ile Ser Phe 85 90 95 Glu Ser Cys Leu Ser Gln Met Phe Phe Ile His Phe Phe Thr Ala Met 100 105 110 Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile 115 120 125 Cys Lys Pro Leu Arg Tyr Thr Met Ile Leu Thr Asn Arg Ile Ile Ile 130 135 140 Ile Ile Ala Gly Ile Ala Ile Leu Arg Ser Leu Cys Met Val Ile Pro 145 150 155 160 Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly His His Ile Ile 165 170 175

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Pro His Thr Tyr 180 Cys Glu His Met Gly Ile 185 Ala Arg Leu Ala Cys Ala 190 Ser Ile Lys Val Asn Ile Ile Phe Gly Leu Gly Asp Met Ser Ile Leu 195 200 205 Leu Leu Asp Val Leu Leu Ile Thr Leu Ser Tyr Val Arg Ile Leu His 210 215 220 Ala Val Phe Cys Leu Pro Ser Lys Glu Ala Arg Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Gly Ser His Ile Gly Val Ile Ser Ala Phe Phe Thr Pro Ala 245 250 255 Phe Phe Ser Phe Leu Thr His Arg Phe Gly His Asn Ile Pro Gln Tyr 260 265 270 Ile His Ile Phe Leu Ala Asn Leu Tyr Ile Val Val Pro Pro Ala Leu 275 280 285 Asn Pro Ala Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg Val 290 295 300 Leu Arg Ile Phe Phe Lys Asp Ile 305 310

<210> 1183 <211> 954 <212> DNA <213> Canis familiaris <400> 1183 atgccagaaa gaatggctac acctaatgat acccagttcc atccctcttc gttcctcctc ctgggtatcc cagaactaga agatgtgcag ttctggatcg gatttccctt tttctttgtg tatcttgttg cactcctggg gaatgctgct gtcctatttg tgatccagac tgagcatagt ctccatgagc ccatgtacta ctttctggcc atgttggact ccattgacct gggcttgtcc acagccacca tccccaaaat gttgggcatc ttctggttca gcctcagaga tatatctttt

120

180

240

300

Page 1333

069269_0225_S .L.TXT gaaagctgtc tttcccagat gttcttcatc catttcttca ctgtcatgga gagcattgtg 360 ttggtggcca tggcctttga ccgctacatt gccatttgta aacctcttcg gtacaccatg 420 atcctcacca gcaaaatcat catcatcatt gcaggcattg ctattctgag gagtctttgc 480 atggtgatcc cactggtgtt tctcctcctg aggctgccct tctgtgggca ccatatcatc 540 cctcatacct attgtgaaca catgggcatt gcccgtctgg cttgtgccag catcaaagtc 600 aacattctat ttggccttgg caacatttct ctcttattat tggatgtgct ccttataatt 660 ctctcctatg tcaggatcct ccatgctgtc ttctgtttgc cctccaggga ggctcgactc 720 aaagctctca acacctgtgg ctcccacatt ggtgttatct tagccttttt cactccagcc 780 tttttctctt tcttgacaca tcgatttggc cacaatattc ctcaatatat tcacattttc 840 ttggctaatc tgtatgtagt tgttccacca gctttcaatc ctgtaattta tggggtcagg 900 accaagcaga tcagggagcg agtcctgagg gttttcttta ggacagagag ctaa 954 <210> 1184 <211> 317 <212> PRT <213> Canis familiaris <400> 1184 Met Pro Glu Arg Met Ala Thr Pro Asn Asp Thr Gln Phe His Pro Ser 1 5 10 15 Ser Phe Leu Leu Leu Gly Ile Pro Glu Leu Glu Asp Val Gln Phe Trp 20 25 30 Ile Gly Phe Pro Phe Phe Phe Val Tyr Leu Val Ala Leu Leu Gly Asn 35 40 45 Ala Ala Val Leu Phe Val Ile Gln Thr Glu His Ser Leu His Glu Pro 50 55 60 Met Tyr Tyr Phe Leu Ala Met Leu Asp Ser Ile Asp Leu Gly Leu Ser 65 70 75 80 Thr Ala Thr Ile Pro Lys Met Leu Gly Ile Phe Trp Phe Ser Leu Arg 85 90 95

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Asp Ile Ser Phe 100 Glu Ser Cys Leu Ser Gln Met Phe Phe Ile His Phe 105 110 Phe Thr Val Met Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg 115 120 125 Tyr Ile Ala Ile Cys Lys Pro Leu Arg Tyr Thr Met Ile Leu Thr Ser 130 135 140 Lys Ile Ile Ile Ile Ile Ala Gly Ile Ala Ile Leu Arg Ser Leu Cys 145 150 155 160 Met Val Ile Pro Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly 165 170 175 His His Ile Ile Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg 180 185 190 Leu Ala Cys Ala Ser Ile Lys Val Asn Ile Leu Phe Gly Leu Gly Asn 195 200 205 Ile Ser Leu Leu Leu Leu Asp Val Leu Leu Ile Ile Leu Ser Tyr Val 210 215 220 Arg Ile Leu His Ala Val Phe Cys Leu Pro Ser Arg Glu Ala Arg Leu 225 230 235 240 Lys Ala Leu Asn Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe 245 250 255 Phe Thr Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His Asn 260 265 270 Ile Pro Gln Tyr Ile His Ile Phe Leu Ala Asn Leu Tyr Val Val Val 275 280 285 Pro Pro Ala Phe Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile 290 295 300

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Arg Glu Arg Val Leu Arg Val Phe Phe Arg Thr Glu Ser 305 310 315 <210> 1185 <211> 942 <212> DNA <213> Canis familiaris <400> 1185

atggctacac ctaatgacac ccagttccat ccctcttcct tccttctcct gggtattcca 60 gggctagaag atgtgcattt ctggatcgga tttccctttt tctttgtgta tcttgttgca 120 ctcctgggga atgctgctgt cctgtttgtg atccagactg agcatagtct ccatgagccc 180 atgtactact ttctggccat gttggactcc attgatctgg gcttgtccac agccaccatc 240 cccaaaatgt tgggcatctt ctggttcagc ctcagagata tatcttttga aagctgtctt 300 tcccagatgt tcttcatcca tttcttcact gccatggaga gcattgtgtt ggtggccatg 360 gcctttgacc gctacattgc catttgtaaa cctcttcggt acaccatgat cctcaccagc 420 aaaatcatca tcatcattgc agggattgct attctgagga gtctttgcat ggtgatccca 480 ctggtgtttc tcctcctgag gctgcccttc tgtgggcacc atatcatccc tcatacctat 540 tgtgaacaca tgggcattgc ccgtctggct tgtgccagca tcaaagtcaa cattctattt 600 ggccttggca acatttctct cttattattg gatgtgctcc ttataattct ctcctatgtc 660 aggatcctcc atgctgtctt ctgtttgccc tccagggagg ctcgactcaa agctctcaac 720 acctgtggct cccacattgg tgttatctta gcctttttca ctccagcctt tttctctttc 780 ttgacacatc gatttggcca caatattcct caatatattc acattttctt ggctaatctg 840 tatgtagttg ttccaccagc tttcaatcct gtaatttatg gggtcaggac caagcagatc 900 agggagcgag tcctgagggt tttctttagg acagatagct aa 942

<210> 1186 <211> 313 <212> PRT <213> Canis familiaris <400> 1186

Met Ala Thr Pro Asn Asp Thr Gln Phe His Pro Ser Ser Phe Leu Leu 1 5 10 15

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Leu Gly Ile Pro 20 Gly Leu Glu Asp Val His Phe Trp Ile Gly Phe Pro 25 30 Phe Phe Phe Val Tyr Leu Val Ala Leu Leu Gly Asn Ala Ala Val Leu 35 40 45 Phe Val Ile Gln Thr Glu His Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Met Leu Asp Ser Ile Asp Leu Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Ser Leu Arg Asp Ile Ser Phe 85 90 95 Glu Ser Cys Leu Ser Gln Met Phe Phe Ile His Phe Phe Thr Ala Met 100 105 110 Glu Ser Ile Val Leu Val Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile 115 120 125 Cys Lys Pro Leu Arg Tyr Thr Met Ile Leu Thr Ser Lys Ile Ile Ile 130 135 140 Ile Ile Ala Gly Ile Ala Ile Leu Arg Ser Leu Cys Met Val Ile Pro 145 150 155 160 Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly His His Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala 180 185 190 Ser Ile Lys Val Asn Ile Leu Phe Gly Leu Gly Asn Ile Ser Leu Leu 195 200 205 Leu Leu Asp Val Leu Leu Ile Ile Leu Ser Tyr Val Arg Ile Leu His 210 215 220

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Ala 225 Val Phe Cys Leu Pro 230 Ser Arg Glu Ala Arg Leu Lys Ala Leu Asn 235 240 Thr Cys Gly Ser His Ile Gly Val Ile Leu Ala Phe Phe Thr Pro Ala 245 250 255 Phe Phe Ser Phe Leu Thr His Arg Phe Gly His Asn Ile Pro Gln Tyr 260 265 270 Ile His Ile Phe Leu Ala Asn Leu Tyr Val Val Val Pro Pro Ala Phe 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg Val 290 295 300 Leu Arg Val Phe Phe Arg Thr Asp Ser

305 310 <210> 1187 <211> 936 <212> DNA <213> Canis familiaris <400> 1187

atgacttcca tcaatgacac tcagttccat ccccccttct ttcacctgct aggaatccca 60 gggctggaaa ctgtccgcat ctggattgct ttcccattct gtgttgtgta tctgattgcc 120 ctcgtgggga acatctccat cctgtttgca atcaagactg aacacagtct ccaccagccc 180 atgttctact tcctggccat gttgtctatg atcgatctgg gtctgtccac gtccaccatc 240 cccaaaatgc tgagcatctt ctggttcaac ctccaagaga tcagcttcag gggctgcctt 300 actcagatgt tcttcatcca catgttcaca ggcatggaga ctgttctcct ggtggccatg 360 gcttatgacc gctttgttgc catctgcaac cctctccagt acaccatgat cctcaccaat 420 aaaacaatcg gcatcctcgc ctctgttgtt gttggaagaa atttaattct ggtgactcca 480 tttgtgtttc tcattctgag gctgcccttc tgtgggcatc acgtcatccc tcatacgtac 540 tgtgagcaca tgggtcttgc ctggttggcc tgtgcaccca tcaaggtcaa cattatctat 600

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gggctcatgg tgatttccaa tatcattgtg gatgtgatcc tgattgcttc gtcctatgtg 660 cttatccttc aagctgtttt ccgccttcct tctcaggatg cccgactaaa ggctctcaat 720 acctgtggtt ctcatgtctg tgtcatgctg tacttttaca caccggcatt tttttctttc 780 atgacacacc gttttggtcg aaacatcccc cgctatatcc atatcctttt agctaatcta 840 tatgtggttg tcccacctgc cctcaaccca gtcatctatg gagtcaggac caagcagatc 900 cgagagacag ttgtgaagat atttgtacag aaataa 936

<210> 1188 <211> 311 <212> PRT <213> Canis familiaris

<400> 1188 Asp Thr Gln Phe His Pro Pro Phe Phe His Leu Met 1 Thr Ser Ile Asn 5 10 15 Leu Gly Ile Pro Gly Leu Glu Thr Val Arg Ile Trp Ile Ala Phe Pro 20 25 30 Phe Cys Val Val Tyr Leu Ile Ala Leu Val Gly Asn Ile Ser Ile Leu 35 40 45 Phe Ala Ile Lys Thr Glu His Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ser Met Ile Asp Leu Gly Leu Ser Thr Ser Thr Ile 65 70 75 80 Pro Lys Met Leu Ser Ile Phe Trp Phe Asn Leu Gln Glu Ile Ser Phe 85 90 95 Arg Gly Cys Leu Thr Gln Met Phe Phe Ile His Met Phe Thr Gly Met 100 105 110 Glu Thr Val Leu Leu Val Ala Met Ala Tyr Asp Arg Phe Val Ala Ile 115 120 125

Cys Asn Pro Leu Gln

Tyr Thr Met

Ile Leu Thr Asn

Lys Thr Ile Gly

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130 135 140

Ile Leu Ala Ser Val Val Val Gly Arg Asn Leu Ile 145 150 155 Phe Val Phe Leu Ile Leu Arg Leu Pro Phe Cys Gly 165 170 Pro His Thr Tyr Cys Glu His Met Gly Leu Ala Trp 180 185 Pro Ile Lys Val Asn Ile Ile Tyr Gly Leu Met Val 195 200 Ile Val Asp Val Ile Leu Ile Ala Ser Ser Tyr Val 210 215 220 Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg Leu 225 230 235 Thr Cys Gly Ser His Val Cys Val Met Leu Tyr Phe 245 250 Phe Phe Ser Phe Met Thr His Arg Phe Gly Arg Asn 260 265 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val 275 280 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile 290 295 300 Val Lys Ile Phe Val Gln Lys 305 310

Leu Val Thr Pro 160

His His Val Ile 175

Leu Ala Cys Ala 190

Ile Ser Asn Ile 205

Leu Ile Leu Gln

Lys Ala Leu Asn 240

Tyr Thr Pro Ala 255

Ile Pro Arg Tyr 270

Pro Pro Ala Leu 285

Arg Glu Thr Val <210> 1189 <211> 963 <212> DNA <213> Canis familiaris

Page 1340

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<400> 1189 atgctccttt cccactccta tgtcaacatc tccttcttcc agccacatgc cttcctgatg 60 attggcatcc cagggctgga ggctgttcat ggatggatct ccatcccctt ctctttcatg 120 tacactgtgg ccctcactgg aaactgcctg attctcttgg ctgtgaggag aactcccagc 180 ttgcaccagc ccatgtacta cttcctgtcc atgctggccc tcactgatgt gggcctcact 240 ctgtccacac tgccaaccac cctggctgtg ctctggtttg attatcggca cataggcttc 300 aatgcctgcc tggttcagat gttcttcctc cactccttct ctgtggtgga gtcatcagtg 360 ctcctggcca tgtcatttga ccgctttgtg gccatctcta accctcttcg ctatgcagct 420 accctcacca ataatgtcat tattaggatt gggctggcca ttatggctag agccactgta 480 tccctctttc cagggccctt cttattgaag cgactgaact tttgccctga caagatcctc 540 ctgtcccatt ccttctgttt ccatgcagat gtcatgaaac gggcttgtgc tgacattact 600 gtcaacatcc tttatgggct atatgtagtt ttatccacag taggtgtaga ctctttgttt 660 attgtcctgt cctataccct tattcttcat acagtgatgg gtctggcctc tcccagggag 720 cgtgtccgag ccctcaacac atgtgtgtct catatattag ctgttctgat tttctacatc 780 ccagtcatag gagtgtcaat gatccaccgt tttgggaggc acctgcctca cattgtacat 840 gctctggttg cctatgtgta cctggtggtg ccccctgtgc tcaaccccat catctacagt 900 gtgaaatcca agcccattag ggaggctatg ctcagactgc tgagaaagaa gaggaaaggc 960

tga 963 <210> 1190 <211> 320 <212> PRT <213> Canis familiaris <400> 1190

Met 1 Leu Leu Ser His 5 Ser Tyr Val Asn Ile Ser Phe Phe Gln Pro His 10 15 Ala Phe Leu Met Ile Gly Ile Pro Gly Leu Glu Ala Val His Gly Trp 20 25 30 Ile Ser Ile Pro Phe Ser Phe Met Tyr Thr Val Ala Leu Thr Gly Asn

35 40 45

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Leu 50 Ile Leu Leu Ala Val 55 Arg Arg Thr Pro Ser Leu His Gln Pro 60 Tyr Tyr Phe Leu Ser Met Leu Ala Leu Thr Asp Val Gly Leu Thr 70 75 80 Ser Thr Leu Pro Thr Thr Leu Ala Val Leu Trp Phe Asp Tyr Arg 85 90 95 Ile Gly Phe Asn Ala Cys Leu Val Gln Met Phe Phe Leu His Ser 100 105 110 Ser Val Val Glu Ser Ser Val Leu Leu Ala Met Ser Phe Asp Arg 115 120 125 Val Ala Ile Ser Asn Pro Leu Arg Tyr Ala Ala Thr Leu Thr Asn 130 135 140 Val Ile Ile Arg Ile Gly Leu Ala Ile Met Ala Arg Ala Thr Val 150 155 160 Leu Phe Pro Gly Pro Phe Leu Leu Lys Arg Leu Asn Phe Cys Pro 165 170 175 Lys Ile Leu Leu Ser His Ser Phe Cys Phe His Ala Asp Val Met 180 185 190 Arg Ala Cys Ala Asp Ile Thr Val Asn Ile Leu Tyr Gly Leu Tyr 195 200 205 Val Leu Ser Thr Val Gly Val Asp Ser Leu Phe Ile Val Leu Ser 210 215 220 Thr Leu Ile Leu His Thr Val Met Gly Leu Ala Ser Pro Arg Glu 230 235 240 Val Arg Ala Leu Asn Thr Cys Val Ser His Ile Leu Ala Val Leu 245 250 255

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Ile Phe Tyr Ile Pro Val Ile Gly Val 265 Ser Met Ile His Arg 270 Phe Gly 260 Arg His Leu Pro His Ile Val His Ala Leu Val Ala Tyr Val Tyr Leu 275 280 285 Val Val Pro Pro Val Leu Asn Pro Ile Ile Tyr Ser Val Lys Ser Lys 290 295 300 Pro Ile Arg Glu Ala Met Leu Arg Leu Leu Arg Lys Lys Arg Lys Gly 305 310 315 320

<210> 1191 <211> 945 <212> DNA <213> Canis familiaris <400> 1191

atgtcttctc tcaatgtcac tgaattccac ccttcttcat tcctattgtt ggggattcca 60 gggttggaaa ttgcacaaat ctggcttgga tttcccttct gtgctgtgta tctgatcgcc 120 cttattggaa atgttatcat tctgtttgtt atctggactg atcatagcct tcaccaaccc 180 atgttctact ttctggccat gctgtcagtg attgacctaa gtctctctac aactaccatc 240 cccaagatgc tgggtatctt ctggttcaac cttcaggagc tatgctttgg gtgctgtgtt 300 gctcaagtct tttttgtcca cttttttaca gtcatggaga gcattgtact tcttgccatg 360 ggttttgatc gctatgtggc tatttgcaac cccctcaggt acaacatgat cctcaccaac 420 agagtcattg gtgtgattgc tgtggtggtg gttctaagaa gcgtattcat gattgctccc 480 atcatttttc tcctcctgag gctgccttac tgtggacata gaatcatccc tcatacctat 540 tgtgagcaca tgggagtggc acgtctagct tgtgccagca ttaatgccaa tgtctactat 600 ggtcttggga atatttctat cttgtttctg gatgtgtttc tcatcattat ctcttatttt 660 aagatcttat atgctgtctt ccacctctcc tcccaagatg ctcgcctgaa ggctctgaat 720 acctgtagtt cccatatttg tgtcatcttt gccttctttg gtccagctct cttttccttt 780 cttactcacc gctttggtca taatgtcccc cagtatatcc acatactcct ggctaatctc 840

Page 1343

900

945

069269_0225_SL.TXT tatgtagtca taccccctgc ccttaaccca gtcatttatg gcatcaggac caagcagatc caggagcggg tacagagttt ctttgttgaa aaaaagattg aatga <210> 1192 <211> 314 <212> PRT <213> Canis familiaris <400> 1192

Met Ser Ser Leu Asn Val Thr Glu Phe His Pro Ser Ser Phe Leu Leu 1 5 10 15 Leu Gly Ile Pro Gly Leu Glu Ile Ala Gln Ile Trp Leu Gly Phe Pro 20 25 30 Phe Cys Ala Val Tyr Leu Ile Ala Leu Ile Gly Asn Val Ile Ile Leu 35 40 45 Phe Val Ile Trp Thr Asp His Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ser Val Ile Asp Leu Ser Leu Ser Thr Thr Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Gln Glu Leu Cys Phe 85 90 95 Gly Cys Cys Val Ala Gln Val Phe Phe Val His Phe Phe Thr Val Met 100 105 110 Glu Ser Ile Val Leu Leu Ala Met Gly Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Asn Met Ile Leu Thr Asn Arg Val Ile Gly 130 135 140 Val Ile Ala Val Val Val Val Leu Arg Ser Val Phe Met Ile Ala Pro 145 150 155 160 Ile Ile Phe Leu Leu Leu Arg Leu Pro Tyr Cys Gly His Arg Ile Ile

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165

Pro His Thr Tyr 180 Cys Glu His Met Ser Ile Asn 195 Ala Asn Val Tyr Tyr 200 Phe Leu 210 Asp Val Phe Leu Ile 215 Ile Ala 225 Val Phe His Leu Ser 230 Ser Gln Thr Cys Ser Ser His 245 Ile Cys Val Leu Phe Ser Phe 260 Leu Thr His Arg Ile His Ile 275 Leu Leu Ala Asn Leu 280 Asn Pro 290 Val Ile Tyr Gly Ile 295 Arg Gln 305 Ser Phe Phe Val Glu 310 Lys Lys

Ile Glu

170 Ala Arg 175 Ala Gly 185 Val Leu Ala 190 Cys Gly Leu Gly Asn Ile 205 Ser Ile Leu Ile Ser Tyr Phe 220 Lys Ile Leu Tyr Asp Ala Arg 235 Leu Lys Ala Leu Asn 240 Ile Phe 250 Ala Phe Phe Gly Pro 255 Ala Phe 265 Gly His Asn Val Pro 270 Gln Tyr Tyr Val Val Ile Pro 285 Pro Ala Leu Thr Lys Gln Ile 300 Gln Glu Arg Val

<210> 1193 <211> 936 <212> DNA <213> Canis familiaris <400> 1193 atgacttcca tcaatgacac tcagttccat gggctggaaa ctgtccacat ctggattgct cttgtgggga acatcaccat cctgtttgca atgttctact tcctggccat gttgtctatg ccccccttct ttcacctgct aggaatccca ttcccattct gtattgtgta tctgattgcc atcaagactg aacacagtct ccaccagccc atcgatctgg gtctgtccac gtccaccatc

120

180

240

Page 1345

069269_0225_SL.TXT cccaaaatgc tgagcatctt ctggttcaac ctccaagaga tcagcttcag gggctgcctt actcagatgt tcttcatcca catgttcaca ggcatggaga ctgttctcct ggtggccatg gcttatgacc gctttgttgc catctgcaac cctctccagt acaccatgat cctcaccaat aaaacaatcg gcatcctcgc ctctgttgtt gttggaagaa acttaattct ggtgactcca tttgtgtttc tcattctgag gctgcccttc tgtgggcatc acgtcatccc tcatacgtac tgtgagcaca tgggtcttgc ccggttggcc tgtgcaccca tcaaggtcaa cattatctat gggctcatgg tgatttccaa tatcattgtg gatgtgatcc tgattgcttc gtcctatgtg cttatccttc aagctgtttt ccgccttcct tctcgggatg cccgactaaa ggctctcaat acctgtggtt ctcatgtctg tgtcatgctg tgcttttaca caccggcatt tttttctttc atgacacacc gttttggtcg aaacatcccc cgctatatcc atatcctttt agctaatcta tatgtggttg tcccacctgc cctcaaccca gtcatctatg gagtcaggac caagcagatc cgagagacag ttgtgaagat atttgtacag aaataa <210> 1194 <211> 311 <212> PRT <213> Canis familiaris

300

360

420

480

540

600

660

720

780

840

900

936

<400> 1194 Met Thr Ser Ile 1 Asn 5 Asp Thr Gln Phe His Pro Pro Phe Phe His Leu 10 15 Leu Gly Ile Pro Gly Leu Glu Thr Val His Ile Trp Ile Ala Phe Pro 20 25 30 Phe Cys Ile Val Tyr Leu Ile Ala Leu Val Gly Asn Ile Thr Ile Leu 35 40 45 Phe Ala Ile Lys Thr Glu His Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ser Met Ile Asp Leu Gly Leu Ser Thr Ser Thr Ile 65 70 75 80

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Pro Lys Met Leu Ser Ile Phe Trp Phe Asn Leu Gln Glu Ile Ser Phe 85 90 95 Arg Gly Cys Leu Thr Gln Met Phe Phe Ile His Met Phe Thr Gly Met 100 105 110 Glu Thr Val Leu Leu Val Ala Met Ala Tyr Asp Arg Phe Val Ala Ile 115 120 125 Cys Asn Pro Leu Gln Tyr Thr Met Ile Leu Thr Asn Lys Thr Ile Gly 130 135 140 Ile Leu Ala Ser Val Val Val Gly Arg Asn Leu Ile Leu Val Thr Pro 145 150 155 160 Phe Val Phe Leu Ile Leu Arg Leu Pro Phe Cys Gly His His Val Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Leu Ala Arg Leu Ala Cys Ala 180 185 190 Pro Ile Lys Val Asn Ile Ile Tyr Gly Leu Met Val Ile Ser Asn Ile 195 200 205 Ile Val Asp Val Ile Leu Ile Ala Ser Ser Tyr Val Leu Ile Leu Gln 210 215 220 Ala Val Phe Arg Leu Pro Ser Arg Asp Ala Arg Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Met Leu Cys Phe Tyr Thr Pro Ala 245 250 255 Phe Phe Ser Phe Met Thr His Arg Phe Gly Arg Asn Ile Pro Arg Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Ala Leu 275 280 285

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Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Thr Val 290 295 300

Val Lys Ile Phe Val Gln Lys 305 310 <210> 1195 <211> 942 <212> DNA <213> Canis familiaris <400> 1195

atgctgcatt ccaacaatac acagttccat cctccctcct tccttctggt ggggattcca 60 ggactacaag atgtgcacat ctggattggc ttcccctttt ttgcagtgta tctgatagcc 120 cttctgggga acatcactat cctgttcgtg atccagatgg aacatagcct ccaccaaccc 180 atgttttact tcctggccat gttggcctgc actgaccttg gcttgtccac agccaccatc 240 cccaagatgc tgggcatttt ctggttcaat ctcagggaga ttgggtttgg tgcttgcatc 300 acacagatgt acactatcca tatatgtacc ggcctggagt ctgtggtgct gacagttatg 360 gccatagatc gatatattgc catctgcaac cccttgagat atagcatgat ccttaccaat 420 aaggtgatag ctatcctgag catagtcatc atagtcagga ctttggtgtt tgtgactcca 480 ttcatatttc tcatcctgag attgcctttc tgtggtgtcc gggttatcct tcatacctac 540 tgtgaacata tgggcttggc aaagttggct tgtgccaata ttagggtcaa tgttgtgtat 600 ggattgattg ctttctcagt gggatacatt gatctatctg tgattggatt ctcctacgtc 660 caaatcctcc gagcagtctt ccacctcccc tcctgggatg cccggctcaa ggcactcaac 720 acatgtggct cgcatgtctg tgtcatgtta gctttctacc tgccagccct cttctccttc 780 atgacacatc gctttggcca caacattcct cattacatcc acattcttct ggccaatctg 840 tacgtggttg ttccccctgc tcttaaccct gttatctatg gggtcaggac aaaacagata 900 agagagcgtg tactaaggat acttatccct aaagcctatt ga 942

<210> 1196 <211> 313 <212> PRT <213> Canis familiaris

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<400> 1196 Met 1 Leu His Ser Asn Asn Thr Gln Phe His Pro Pro Ser Phe Leu Leu 5 10 15 Val Gly Ile Pro Gly Leu Gln Asp Val His Ile Trp Ile Gly Phe Pro 20 25 30 Phe Phe Ala Val Tyr Leu Ile Ala Leu Leu Gly Asn Ile Thr Ile Leu 35 40 45 Phe Val Ile Gln Met Glu His Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Cys Thr Asp Leu Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Arg Glu Ile Gly Phe 85 90 95 Gly Ala Cys Ile Thr Gln Met Tyr Thr Ile His Ile Cys Thr Gly Leu 100 105 110 Glu Ser Val Val Leu Thr Val Met Ala Ile Asp Arg Tyr Ile Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ser Met Ile Leu Thr Asn Lys Val Ile Ala 130 135 140 Ile Leu Ser Ile Val Ile Ile Val Arg Thr Leu Val Phe Val Thr Pro 145 150 155 160 Phe Ile Phe Leu Ile Leu Arg Leu Pro Phe Cys Gly Val Arg Val Ile 165 170 175 Leu His Thr Tyr Cys Glu His Met Gly Leu Ala Lys Leu Ala Cys Ala 180 185 190 Asn Ile Arg Val Asn Val Val Tyr Gly Leu Ile Ala Phe Ser Val Gly 195 200 205

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Tyr Ile Asp Leu Ser Val Ile Gly Phe Ser Tyr Val Gln Ile Leu Arg 210 215 220 Ala Val Phe His Leu Pro Ser Trp Asp Ala Arg Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Met Leu Ala Phe Tyr Leu Pro Ala 245 250 255 Leu Phe Ser Phe Met Thr His Arg Phe Gly His Asn Ile Pro His Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Ala Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg Val 290 295 300 Leu Arg Ile Leu Ile Pro Lys Ala Tyr 305 310

<210> 1197 <211> 942 <212> DNA <213> Canis familiaris <400> 1197

atggcttcat ccagcaacta ctccactgct ccagtctctg aattcctcct catctgcttc 60 cctaactacc agagttggca gcattggctg tccctgcctc tcagcctcct cttcctcctg 120 gccatggggg ccaatgccac cctcttgatc actatcctgc tggaggcctc tctgcacgag 180 cccatgtact acctactcgg cctcctctcc ctgctggaca ttgtgctctg cctcactgtc 240 atccccaagg tcctggccat cttctggttt gatctcaggt ccatcagctt ctcagcctgc 300 ttcctccaga tgttcatcat gaacagtttt ttgaccatgg agtcctgcac attcatggtc 360 atggcctatg accgctatgt ggccatctgc cacccactga ggtacccatc catcatcact 420 gaccaatttg tggttagagc tgccatattt attgtggcca ggaatagtat cttttctctt 480 cctgttcctg ttctttcttc caggcttaga tactgtgcag aaaacattat caagaactgt 540

Page 1350

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atctgcacta acctgtctgt gtccaaactc tcctgtgatg acatcacctt caatcggctc 600 taccagtttg tggcaggctg gaccctactg ggctctgacc tcatccttat tgttttgtcc 660 tactccttca tcctgaaagc tgtgctaagg atcaaggctg agggtgctac agccaaggcc 720 ctaagcacat gtggttccca cttcatcctc atcctcttct tcagcacagt cctgttggtt 780 ctggtcatca ctaacctggc caggaagaga attcccccag atgtccccat cctactcaac 840 atcctgcacc acctcatccc cccagctctg aaccccattg tttatggtgt gagaactaag 900 gagatcaacc aaggaatcca gaagctgctg agaaggttgt aa 942

<210> 1198 <211> 313 <212> PRT <213> Canis familiaris

<400> 1198 Asn Tyr Ser Thr Ala Pro Val Ser Glu Phe Leu Met 1 Ala Ser Ser Ser 5 10 15 Leu Ile Cys Phe Pro Asn Tyr Gln Ser Trp Gln His Trp Leu Ser Leu 20 25 30 Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala Asn Ala Thr Leu 35 40 45 Leu Ile Thr Ile Leu Leu Glu Ala Ser Leu His Glu Pro Met Tyr Tyr 50 55 60 Leu Leu Gly Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr Val 65 70 75 80 Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Ile Ser 85 90 95 Phe Ser Ala Cys Phe Leu Gln Met Phe Ile Met Asn Ser Phe Leu Thr 100 105 110 Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125

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Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asp Gln Phe Val 130 135 140 Val Arg Ala Ala Ile Phe Ile Val Ala Arg Asn Ser Ile Phe Ser Leu 145 150 155 160 Pro Val Pro Val Leu Ser Ser Arg Leu Arg Tyr Cys Ala Glu Asn Ile 165 170 175 Ile Lys Asn Cys Ile Cys Thr Asn Leu Ser Val Ser Lys Leu Ser Cys 180 185 190 Asp Asp Ile Thr Phe Asn Arg Leu Tyr Gln Phe Val Ala Gly Trp Thr 195 200 205 Leu Leu Gly Ser Asp Leu Ile Leu Ile Val Leu Ser Tyr Ser Phe Ile 210 215 220 Leu Lys Ala Val Leu Arg Ile Lys Ala Glu Gly Ala Thr Ala Lys Ala 225 230 235 240 Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr 245 250 255 Val Leu Leu Val Leu Val Ile Thr Asn Leu Ala Arg Lys Arg Ile Pro 260 265 270 Pro Asp Val Pro Ile Leu Leu Asn Ile Leu His His Leu Ile Pro Pro 275 280 285 Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys Glu Ile Asn Gln 290 295 300 Gly Ile Gln Lys Leu Leu Arg Arg Leu 305 310

<210> 1199 <211> 978

Page 1352

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 1199

atgacagcac accaaaatgg caccatctcc actggggctt cagagtttct cctgaattgt 60 tttgtcaggt cccccacttg gcagctctgg ttatccctgc ccctcggcct cttgttcctc 120 gtggccatgg gggccaatgg tgttctcctg atcaccatct ggctggaggc ctctctacac 180 cagcccctgt actacctgct gagcctcctc tccctcctgg acattgttct ctgcctcact 240 gtcatcccca aggtcctggc catcttttgg tttgacctca agtccatcag ctttgatgcc 300 tgcttcttac agatgttcat catgaatttc ttctatgcca tggagtcctg cacattcatg 360 gtcatggcct atgaccgcta tgtggccatc tgccacccac tgaggtaccc atccatcata 420 cccactgagg tacccatcca tcatacagaa caatttgtag ctaaggctgc catttttatt 480 ttggccagga atgctatttc tacattgcct atccccattc tctcatccag actccattat 540 tgtgggagaa atgtcattga gaattgcatc tgtgccaata tgtctgtctc caagctctcc 600 tgtgatgatg tcaccatcaa tcgtctctac cagtttgctg gaggctggac actgctagga 660 tctgacctcg tcctcatctt catctcttac agcctcatac ttcaaactgt gatgggatta 720 aaggcggagg gtgctatggc caaagccctg agcacatgtg gttctcactt catccttatc 780 ctcttcttca gcaccgtcct tctggtcttt gtgctcactc atatggtgac aaagaaggtg 840 tctccaattg agcaagatgt tccagttttg ctcaatgtcc tccaccatgt catccctgca 900 gccttgaacc ccattgttta tggagtgcac acccaggaga tcaaacaagg aatccagaga 960 ttactgaaga agggatgg 978

<210> 1200 <211> 326 <212> PRT <213> Canis familiaris <400> 1200

Met Thr Ala His Gln Asn Gly Thr Ile Ser Thr Gly Ala Ser Glu Phe 1 5 10 15

Leu Leu Asn Cys Phe Val Arg Ser Pro Thr Trp Gln Leu Trp Leu Ser 20 25 30

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Leu Pro Leu 35 Gly Leu Leu Phe Leu Val Ala Met Gly Ala Asn Gly Val 40 45 Leu Leu Ile Thr Ile Trp Leu Glu Ala Ser Leu His Gln Pro Leu Tyr 50 55 60 Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr 65 70 75 80 Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Lys Ser Ile 85 90 95 Ser Phe Asp Ala Cys Phe Leu Gln Met Phe Ile Met Asn Phe Phe Tyr 100 105 110 Ala Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Pro Thr Glu Val 130 135 140 Pro Ile His His Thr Glu Gln Phe Val Ala Lys Ala Ala Ile Phe Ile 145 150 155 160 Leu Ala Arg Asn Ala Ile Ser Thr Leu Pro Ile Pro Ile Leu Ser Ser 165 170 175 Arg Leu His Tyr Cys Gly Arg Asn Val Ile Glu Asn Cys Ile Cys Ala 180 185 190 Asn Met Ser Val Ser Lys Leu Ser Cys Asp Asp Val Thr Ile Asn Arg 195 200 205 Leu Tyr Gln Phe Ala Gly Gly Trp Thr Leu Leu Gly Ser Asp Leu Val 210 215 220 Leu Ile Phe Ile Ser Tyr Ser Leu Ile Leu Gln Thr Val Met Gly Leu 225 230 235 240

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Lys Ala Glu Gly Ala 245 Met Ala Lys Ala Leu Ser Thr Cys Gly Ser His 250 255 Phe Ile Leu Ile Leu Phe Phe Ser Thr Val Leu Leu Val Phe Val Leu 260 265 270 Thr His Met Val Thr Lys Lys Val Ser Pro Ile Glu Gln Asp Val Pro 275 280 285 Val Leu Leu Asn Val Leu His His Val Ile Pro Ala Ala Leu Asn Pro 290 295 300 Ile Val Tyr Gly Val His Thr Gln Glu Ile Lys Gln Gly Ile Gln Arg 305 310 315 320 Leu Leu Lys Lys Gly Trp

325 <210> 1201 <211> 960 <212> DNA <213> Canis familiaris <400> 1201

atgctacctt ataacagcag ctgcctctct actgaagtct cagacttcat cctgaattgc 60 tttgtcaggt ctcccagctg gcagcactgg ctatctctgc ccctcagcat cctcttcctc 120 atggccatgg gggccaatgc cgtcctcctg atcactatac agctagaggc ctctctgcac 180 gagcccatgt actacttgct tggcctcctt tcccttttgg acatcgtgct ctgcctcact 240 gtcatcccca aggtcctggc tatcttctgg tttgatctca ggtccatcag cttctctgcc 300 tgcttcctcc agatgttcat catgaatagc ttcctgccca tggaatcatg caccttcctg 360 gccatggcct atgaccgcta tgtcgccatc tgcaagcctc tgtactaccc aaccatcatc 420 actgaccagt ttgtggtaaa ggctgttctc ttcatcgtgg cccggagcac atttcttact 480 acacctactc ccatcctttc ggcccggctg cattactgtg gaaaaaatat aattgagaac 540 tgtatctgtg ccaacctctc tgtgtccaag ctctcctgtg ataatgttac ccttaacaaa 600 atataccagt taattgtggc ctggactctg ctgagctgtg acctcatcct catcttcctc 660

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tcctatatcc tcatcctaaa aactgttctt agactcaagg caaaaggggc agctgccaaa 720 gctctgagca catgcggctc tcacttcatt ctcatcctct tctttagcac catcctgctg 780 gttttggttt ttacccacat tgccaaaaaa aaagtttccc ctgagattcc catcttactt 840 aatgtcctac accatgtaat tcctgcagct ctcaatccca ttgtctatgg gatacgaacc 900 caggagatta aagagggaat taggaagtta ctgaggaggg tagtagagag atgcaagtaa 960

<210> 1202 <211> 319 <212> PRT <213> Canis familiaris

<400> 1202 Met 1 Leu Pro Tyr Asn Ser Ser Cys 5 Leu Ser 10 Thr Glu Val Ser Asp Phe 15 Ile Leu Asn Cys Phe Val Arg Ser Pro Ser Trp Gln His Trp Leu Ser 20 25 30 Leu Pro Leu Ser Ile Leu Phe Leu Met Ala Met Gly Ala Asn Ala Val 35 40 45 Leu Leu Ile Thr Ile Gln Leu Glu Ala Ser Leu His Glu Pro Met Tyr 50 55 60 Tyr Leu Leu Gly Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr 65 70 75 80 Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Ile 85 90 95 Ser Phe Ser Ala Cys Phe Leu Gln Met Phe Ile Met Asn Ser Phe Leu 100 105 110 Pro Met Glu Ser Cys Thr Phe Leu Ala Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys Lys Pro Leu Tyr Tyr Pro Thr Ile Ile Thr Asp Gln Phe 130 135 140

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Val 145 Val Lys Ala Val Leu 150 Phe Ile Val Ala Arg Ser Thr Phe Leu Thr 155 160 Thr Pro Thr Pro Ile Leu Ser Ala Arg Leu His Tyr Cys Gly Lys Asn 165 170 175 Ile Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser Lys Leu Ser 180 185 190 Cys Asp Asn Val Thr Leu Asn Lys Ile Tyr Gln Leu Ile Val Ala Trp 195 200 205 Thr Leu Leu Ser Cys Asp Leu Ile Leu Ile Phe Leu Ser Tyr Ile Leu 210 215 220 Ile Leu Lys Thr Val Leu Arg Leu Lys Ala Lys Gly Ala Ala Ala Lys 225 230 235 240 Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser 245 250 255 Thr Ile Leu Leu Val Leu Val Phe Thr His Ile Ala Lys Lys Lys Val 260 265 270 Ser Pro Glu Ile Pro Ile Leu Leu Asn Val Leu His His Val Ile Pro 275 280 285 Ala Ala Leu Asn Pro Ile Val Tyr Gly Ile Arg Thr Gln Glu Ile Lys 290 295 300 Glu Gly Ile Arg Lys Leu Leu Arg Arg Val Val Glu Arg Cys Lys

305 310 315 <210> 1203 <211> 948 <212> DNA <213> Canis familiaris <400> 1203

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atgacagcac accaaaatgg caccatctcc actggggctt cagagtttct cctgaattgt 60 tttgtcaggt cccccacttg gcagctctgg ttatccctgc ccctcggcct cttgttcctc 120 gtggccatgg gggccaatgg tgttctcctg atcaccatct ggctggaggc ctctctacac 180 cagcccctat actacctgct gagcctcctc tccctcctgg acattgttct ctgcctcact 240 gtcatcccca aggtcctggc catcttttgg tttgacctca agtccatcag ctttgatgcc 300 tgcttcttac agatgttcat catgaatttc ttctatgcca tggagtcctg cacattcatg 360 gtcatggcct atgaccgcta tgtggccatc tgccacccac tgaggtaccc atccatcatc 420 acagaacaat ttgtagctaa ggctgccatt tttattttgg ccaggaatgc tatttctaca 480 ttgcctatcc ccattctctc atccagactc cattattgtg ggagaaatgt cattgagaat 540 tgcatctgtg ccaatatgtc tgtctccaag ctctcctgtg atgatgtcac catcaatcgt 600 ctctaccagt ttgctggagg ctggacactg ctaggatctg acctcgtcct catcttcatc 660 tcttacagcc tcatacttca aactgtgatg ggattaaagg cggagggtgc tatggccaaa 720 gccctgagca catgtggttc tcacttcatc cttatcctct tcttcagcac cgtccttctg 780 gtctttgtgc tcactcatat ggtgacaaag aatgtgtctc ctgatgttcc agtcttgctc 840 aatgtcctcc accatgtcat ccctgcagcc ttgaacccca ttgtttatgg agtgcgcacc 900 caggagatca aacaaggaat ccagagatta ctgaagaagg gatggtag 948

<210> 1204 <211> 315 <212> PRT <213> Canis familiaris

<400> 1204 Met 1 Thr Ala His Gln Asn Gly Thr Ile Ser Thr Gly Ala Ser Glu Phe 5 10 15 Leu Leu Asn Cys Phe Val Arg Ser Pro Thr Trp Gln Leu Trp Leu Ser 20 25 30 Leu Pro Leu Gly Leu Leu Phe Leu Val Ala Met Gly Ala Asn Gly Val 35 40 45 Leu Leu Ile Thr Ile Trp Leu Glu Ala Ser Leu His Gln Pro Leu Tyr Page 1358

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50 55 60 Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr 65 70 75 80 Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Lys Ser Ile 85 90 95 Ser Phe Asp Ala Cys Phe Leu Gln Met Phe Ile Met Asn Phe Phe Tyr 100 105 110 Ala Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Glu Gln Phe 130 135 140 Val Ala Lys Ala Ala Ile Phe Ile Leu Ala Arg Asn Ala Ile Ser Thr 145 150 155 160 Leu Pro Ile Pro Ile Leu Ser Ser Arg Leu His Tyr Cys Gly Arg Asn 165 170 175 Val Ile Glu Asn Cys Ile Cys Ala Asn Met Ser Val Ser Lys Leu Ser 180 185 190 Cys Asp Asp Val Thr Ile Asn Arg Leu Tyr Gln Phe Ala Gly Gly Trp 195 200 205 Thr Leu Leu Gly Ser Asp Leu Val Leu Ile Phe Ile Ser Tyr Ser Leu 210 215 220 Ile Leu Gln Thr Val Met Gly Leu Lys Ala Glu Gly Ala Met Ala Lys 225 230 235 240 Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser 245 250 255 Thr Val Leu Leu Val Phe Val Leu Thr His Met Val Thr Lys Asn Val

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069269_0225_SL.TXT 265 270

Ser Pro Asp 275 Val Pro Val Leu Leu Asn Val Leu His His Val Ile Pro 280 285 Ala Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Gln Glu Ile Lys 290 295 300 Gln Gly Ile Gln Arg Leu Leu Lys Lys Gly Trp 305 310 315

<210> 1205 <211> 945 <212> DNA <213> Canis familiaris <400> 1205

atgctacctt ataacagcag ctgcctctct actgaagtct cagacttcat cctgaattgc 60 tttgtcaggt ctcccagctg gcagcactgg ctatctctgc ccctcagcat cctcttcctc 120 gtggccatgg gggccaatgc cgtcctcctg atcactatac agctagaggc ctctctgcac 180 gagcccatgt actacttgct tggcctcctt tcccttttgg acatcgtgct ctgcctcact 240 gtcatcccca aggtcctggc tatcttctgg tttgatctca ggtccatcag cttctctgcc 300 tgcttcctcc agatgttcat catgaataac ttcctgccca tggaatcatg caccttcctg 360 gccatggcct atgaccgcta tgtcgccatc tgcaacccaa cgattatcac tgaccagttt 420 gtggcaaagg ctgttctctt catcttggcc cggaacacat ttcttactgc acctattccc 480 atcctttcgg cccggctgca ttactgtgga aaaaatataa ttgagaactg tatctgtgcc 540 aacctctctg tgtccaagct ctcctgtgat aatgttgccc ttaacaaaat ataccagtta 600 attgtggcct ggactcttct gggctctgat cttgtcctca tatttatctc ctatatcctc 660 atcctaagag ccattcttag acttaaggca aaaggggcag ctgccaaagc tctgagcaca 720 tgcggctctc acttcatact catcctcttc tttagcacca tcctgctagt ctttgttttt 780 acccacatgg ccaagaaaaa agtttcccct gatattccca tcttacttaa tgtcctacac 840 catgtaattc ctgcagctct caatcccatt gtctatgggg tacgaaccca ggagattaaa 900 gagggaatta ggaaattact gaggagggta gcagagagat gcaag 945

Page 1360

069269_0225_SL.TXT <210> 1206 <211> 315 <212> PRT <213> Canis familiaris

<400> 1206 Ser Cys Leu Ser Thr Glu Val Ser Asp Phe Met 1 Leu Pro Tyr Asn 5 Ser 10 15 Ile Leu Asn Cys Phe Val Arg Ser Pro Ser Trp Gln His Trp Leu Ser 20 25 30 Leu Pro Leu Ser Ile Leu Phe Leu Val Ala Met Gly Ala Asn Ala Val 35 40 45 Leu Leu Ile Thr Ile Gln Leu Glu Ala Ser Leu His Glu Pro Met Tyr 50 55 60 Tyr Leu Leu Gly Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr 65 70 75 80 Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Ile 85 90 95 Ser Phe Ser Ala Cys Phe Leu Gln Met Phe Ile Met Asn Asn Phe Leu 100 105 110 Pro Met Glu Ser Cys Thr Phe Leu Ala Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys Asn Pro Thr Ile Ile Thr Asp Gln Phe Val Ala Lys Ala 130 135 140 Val Leu Phe Ile Leu Ala Arg Asn Thr Phe Leu Thr Ala Pro Ile Pro 145 150 155 160 Ile Leu Ser Ala Arg Leu His Tyr Cys Gly Lys Asn Ile Ile Glu Asn 165 170 175

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Cys Ile Cys Ala Asn Leu Ser Val Ser Lys Leu Ser Cys Asp 190 Asn Val 180 185 Ala Leu Asn Lys Ile Tyr Gln Leu Ile Val Ala Trp Thr Leu Leu Gly 195 200 205 Ser Asp Leu Val Leu Ile Phe Ile Ser Tyr Ile Leu Ile Leu Arg Ala 210 215 220 Ile Leu Arg Leu Lys Ala Lys Gly Ala Ala Ala Lys Ala Leu Ser Thr 225 230 235 240 Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr Ile Leu Leu 245 250 255 Val Phe Val Phe Thr His Met Ala Lys Lys Lys Val Ser Pro Asp Ile 260 265 270 Pro Ile Leu Leu Asn Val Leu His His Val Ile Pro Ala Ala Leu Asn 275 280 285 Pro Ile Val Tyr Gly Val Arg Thr Gln Glu Ile Lys Glu Gly Ile Arg 290 295 300 Lys Leu Leu Arg Arg Val Ala Glu Arg Cys Lys

305 310 315 <210> 1207 <211> 939 <212> DNA <213> Canis familiaris <400> 1207 atgacaacac atcaaaatgg gaccatatcc attgagattt cagactttct cctgaattgt tttgtcaggt ctcccggctg gcaactttct ttctccctgc ccctcagcct cctcttcctc ctggccatgg gggccaatgg tgtcctcctg atcaccatct ggctggaggc ctctctgcac gagcccatgt actacctgct cagcatcctc tccctattgg acatcgtgct ctgcctcact gtcatcccca aagtcctgac cattttctgg tttgatctca agtccatcaa tttctatgcc

120

180

240

300

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tgcttcattc agatgtacat catgaattgc ttccttgcca tggagtcctg cacaatggtc 360 atggcctatg accgctatgt ggccatctgc cacccactga ggtacccatc catcatcaca 420 gaacaatttg tagcgaaggc tgccattttt attttggcca ggaatgctat ttctacagtg 480 cctattccca ttctatcatc cagactccat tattgtgggg gaaatgtcat tgagaattgc 540 atctgtgcca atatgtctgt ctccaagctc tcctgtgatg atgtcaccat caatcgcctc 600 taccagtttg ctgcaggctg gacactgcta ggatctgatc tcatccttat cttcctttcc 660 tacagcctca tactgcgagc tgtgctgaga ctcaaggcag agggtgctat ggccaaagcc 720 ctgagcacat gtggttctca cttcatcctt atcctcttct tcagcactat ccttctggtc 780 tttgtgctca ctcatgtggc aaagaagaaa gtctcccctg atgtgccagt cttgctcaat 840 gttctccacc atgtcattcc tgcagccctc aatcccattg tttatggagt gagaactcag 900 gagatcaagc aaggaatcca gagattacta aacaaaggg 939

<210> 1208 <211> 313 <212> PRT <213> Canis familiaris <400> 1208

Met Thr Thr His Gln Asn Gly Thr Ile Ser Ile Glu Ile Ser Asp Phe 1 5 10 15 Leu Leu Asn Cys Phe Val Arg Ser Pro Gly Trp Gln Leu Ser Phe Ser 20 25 30 Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala Asn Gly Val 35 40 45 Leu Leu Ile Thr Ile Trp Leu Glu Ala Ser Leu His Glu Pro Met Tyr 50 55 60 Tyr Leu Leu Ser Ile Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr 65 70 75 80 Val Ile Pro Lys Val Leu Thr Ile Phe Trp Phe Asp Leu Lys Ser Ile 85 90 95

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Asn Phe Tyr Ala 100 Cys Phe Ile Gln Met Tyr Ile Met Asn Cys Phe Leu 105 110 Ala Met Glu Ser Cys Thr Met Val Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Glu Gln Phe Val 130 135 140 Ala Lys Ala Ala Ile Phe Ile Leu Ala Arg Asn Ala Ile Ser Thr Val 145 150 155 160 Pro Ile Pro Ile Leu Ser Ser Arg Leu His Tyr Cys Gly Gly Asn Val 165 170 175 Ile Glu Asn Cys Ile Cys Ala Asn Met Ser Val Ser Lys Leu Ser Cys 180 185 190 Asp Asp Val Thr Ile Asn Arg Leu Tyr Gln Phe Ala Ala Gly Trp Thr 195 200 205 Leu Leu Gly Ser Asp Leu Ile Leu Ile Phe Leu Ser Tyr Ser Leu Ile 210 215 220 Leu Arg Ala Val Leu Arg Leu Lys Ala Glu Gly Ala Met Ala Lys Ala 225 230 235 240 Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr 245 250 255 Ile Leu Leu Val Phe Val Leu Thr His Val Ala Lys Lys Lys Val Ser 260 265 270 Pro Asp Val Pro Val Leu Leu Asn Val Leu His His Val Ile Pro Ala 275 280 285 Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Gln Glu Ile Lys Gln 290 295 300

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Gly Ile Gln Arg Leu Leu Asn Lys Gly 305 310 <210> 1209 <211> 960 <212> DNA <213> Canis familiaris <400> 1209

atgacagcgc accaaaatgg caccatctcc attgtggttt ccgacttcct cctgaattgt 60 ttagtcaggt ctcccagctg gaagttctgg ttgtccctgc ccctaagctt cctcttcctc 120 ctggccatgg gggccaatgg tgttctcctg gtcaccatcc agctggaggc ctctctgcat 180 gagcccatgt actacctgct cagcatcctc tctctgctgg acatcgtcct ctgcctgact 240 gttataccca aggtcctggc catcttctgg tttgatctca ggtccgtcag cttctctgcc 300 tgcttcattc agatgtacat catgaattgc ttccttggca tggagtcttg cacattcatg 360 gtcatggcct atgaccgcta tgtggccatc tgccacccac tgaggtactc ttccatcatc 420 actgatcaat ttgtagctag ggctgctatg tttattttgg cgaggaatgc acttcttact 480 atgttcattc ctatcctctc tgcccagctc cattattgtg gaaaaaatat aattgagaac 540 tgtatctgtg ccaacctctc tgtgtccaag ctctcctgtg ataatgttgc ccttaacaga 600 atataccagt taactgtagc ctggactctt ctgggctctg acctcgtcct catcttcctc 660 tcctacatcc tcatcctaag agccattctt agactgaagg caaaaggggc agctgccaaa 720 gctctgagca catgcggctc tcacttcatt ctcatcctgt tctttagcac catcctgctg 780 gtttttgttt ttacccacat ggctaagaaa agagtttccc ctgatattcc catcttactt 840 aatgtcctac accatgtaat tcctgcagct ctcaatccca ttgtctatgg ggtacgaacc 900 caggagatta aagagggaat taggaagtta ctgagaaggg tagtagagag atgcaagtaa 960

<210> 1210 <211> 319 <212> PRT <213> Canis familiaris <400> 1210

Met Thr Ala His Gln Asn Gly Thr Ile Ser Ile Val Val Ser Asp Phe 1 5 10 15

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Leu Leu Asn Cys 20 Leu Val Arg Ser Pro Ser Trp Lys Phe Trp Leu Ser 25 30 Leu Pro Leu Ser Phe Leu Phe Leu Leu Ala Met Gly Ala Asn Gly Val 35 40 45 Leu Leu Val Thr Ile Gln Leu Glu Ala Ser Leu His Glu Pro Met Tyr 50 55 60 Tyr Leu Leu Ser Ile Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr 65 70 75 80 Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Val 85 90 95 Ser Phe Ser Ala Cys Phe Ile Gln Met Tyr Ile Met Asn Cys Phe Leu 100 105 110 Gly Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Ser Ser Ile Ile Thr Asp Gln Phe 130 135 140 Val Ala Arg Ala Ala Met Phe Ile Leu Ala Arg Asn Ala Leu Leu Thr 145 150 155 160 Met Phe Ile Pro Ile Leu Ser Ala Gln Leu His Tyr Cys Gly Lys Asn 165 170 175 Ile Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser Lys Leu Ser 180 185 190 Cys Asp Asn Val Ala Leu Asn Arg Ile Tyr Gln Leu Thr Val Ala Trp 195 200 205 Thr Leu Leu Gly Ser Asp Leu Val Leu Ile Phe Leu Ser Tyr Ile Leu 210 215 220

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Ile Leu 225 Arg Ala Ile Leu Arg Leu Lys Ala Lys Gly Ala Ala Ala Lys 230 235 240 Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser 245 250 255 Thr Ile Leu Leu Val Phe Val Phe Thr His Met Ala Lys Lys Arg Val 260 265 270 Ser Pro Asp Ile Pro Ile Leu Leu Asn Val Leu His His Val Ile Pro 275 280 285 Ala Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Gln Glu Ile Lys 290 295 300 Glu Gly Ile Arg Lys Leu Leu Arg Arg Val Val Glu Arg Cys Lys

305 310 315 <210> 1211 <211> 972 <212> DNA <213> Canis familiaris <400> 1211

atgccagcta tgagttcctg caacttcaca cataccacct ttgtacttat tggtatccca 60 ggattagaag aagcccattt ctggatcggc ttccccctgc tttcaatgta tgccgtggca 120 ctatttggaa actgcatcgt tgtcttcatc gtaaggacag agcgcagcct acacgctccc 180 atgtacctct ttctctgcat gttggcagcc attgacttgg ccttgtccac atccaccatg 240 cccaagatcc tcgccctctt ctggtttgat tcccgggaga ttacttttga tgcctgcatt 300 gcccagatgt tttttattca tgctctttca gctattgagt ccactatcct gctggccatg 360 gcctttgacc gttatatagc catctgtcac ccactgcgcc atgcagcagt gctcaacaat 420 acagtaacag cccagattgg catggtggct gtggcccgtg gatcactctt ctttatccca 480 ctgcctctgc tcatcaagcg gctggccttc tgccattcca atgtgctgtc acactcctat 540 tgtgtgcacc aggatatgat gaagttggcc tatgcagata cattgcccaa tgtgatctat 600

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ggtcttacag ccattctgtt ggttatgggt gtggatgtcc tcttcatctc cttgtcctat 660 tttctgatta tacgaacagt tctacaactg ccttccaagt cagagcgggc caaggctttt 720 ggaacctgtg tgtcacacat cggtgtggta ttagccttct atgttcctct cattggcctc 780 tcagtggtac accgttttgg aaacagcctt gatcccattg tgcatgttct catgggtgat 840 gtctatctac ttctgcctcc tgtgatcaat cccatcatct acggtgccaa gaccaaacag 900 atcagaactc gggtgctagc tatgttcaag atcagctgtg acaaggaccc tcaggctgtg 960 ggcagcagat ga 972

<210> 1212 <211> 323 <212> PRT <213> Canis familiaris

<400> 1212 Ser Cys Asn Phe Thr His Thr Thr Phe Val Leu Met 1 Pro Ala Met Ser 5 10 15 Ile Gly Ile Pro Gly Leu Glu Glu Ala His Phe Trp Ile Gly Phe Pro 20 25 30 Leu Leu Ser Met Tyr Ala Val Ala Leu Phe Gly Asn Cys Ile Val Val 35 40 45 Phe Ile Val Arg Thr Glu Arg Ser Leu His Ala Pro Met Tyr Leu Phe 50 55 60 Leu Cys Met Leu Ala Ala Ile Asp Leu Ala Leu Ser Thr Ser Thr Met 65 70 75 80 Pro Lys Ile Leu Ala Leu Phe Trp Phe Asp Ser Arg Glu Ile Thr Phe 85 90 95 Asp Ala Cys Ile Ala Gln Met Phe Phe Ile His Ala Leu Ser Ala Ile 100 105 110 Glu Ser Thr Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile 115 120 125

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Cys His Pro Leu Arg His Ala Ala Val Leu Asn Asn Thr Val Thr Ala 130 135 140 Gln Ile Gly Met Val Ala Val Ala Arg Gly Ser Leu Phe Phe Ile Pro 145 150 155 160 Leu Pro Leu Leu Ile Lys Arg Leu Ala Phe Cys His Ser Asn Val Leu 165 170 175 Ser His Ser Tyr Cys Val His Gln Asp Met Met Lys Leu Ala Tyr Ala 180 185 190 Asp Thr Leu Pro Asn Val Ile Tyr Gly Leu Thr Ala Ile Leu Leu Val 195 200 205 Met Gly Val Asp Val Leu Phe Ile Ser Leu Ser Tyr Phe Leu Ile Ile 210 215 220 Arg Thr Val Leu Gln Leu Pro Ser Lys Ser Glu Arg Ala Lys Ala Phe 225 230 235 240 Gly Thr Cys Val Ser His Ile Gly Val Val Leu Ala Phe Tyr Val Pro 245 250 255 Leu Ile Gly Leu Ser Val Val His Arg Phe Gly Asn Ser Leu Asp Pro 260 265 270 Ile Val His Val Leu Met Gly Asp Val Tyr Leu Leu Leu Pro Pro Val 275 280 285 Ile Asn Pro Ile Ile Tyr Gly Ala Lys Thr Lys Gln Ile Arg Thr Arg 290 295 300 Val Leu Ala Met Phe Lys Ile Ser Cys Asp Lys Asp Pro Gln Ala Val 305 310 315 320

Gly Ser Arg

Page 1369

069269_0225_SL.TXT <210> 1213 <211> 945 <212> DNA <213> Canis familiaris <400> 1213

atgacaacac atcaaaatgg gaccatatcc attgagattt cagactttct cctgaattgt 60 tttgtcaggt ctcccagctg gcaactttct ttctccctgc ccctcagcct cctcttcctc 120 ctggccatgg gggccaatgg tgtcctcctg atcaccatct ggctggaggc ctctttgcac 180 gagcccatgt actacctgct cagcatcctc tccctattgg acatcgtgct ctgcctcact 240 gtcatcccca aagtcctgac cattttctgg tttgatctca agtccatcaa cttctatgcc 300 tgcttcattc agatgtacat catgaattgc ttccttgcca tggagtcctg cacattcatg 360 gtcatggcct atgaccgcta tgtggccatc tgccacccac tgaggtaccc atccatcatc 420 acagaacaat ttgtagcgaa ggctgccatt tttattttgg ccaggaatgc tatttctaca 480 ttgcctattc ccattctatc atccagactc cattattgtg ggggaaatgt cattgagaat 540 tgcatctgtg ccaatatgtc tgtctccaag ctctcctgtg atgatgtcac catcaatcgc 600 ctctaccagt ttgctggagg ctggacactg ctaggatctg atctcatcct tatcttcctc 660 tcctacagcc ttatactgcg agctgtgctg agactcaagg cagagggtgc tatggccaaa 720 gccctgagca catgtggttc tcacttcatc cttatcctct tcttcagcac tatccttctg 780 gtcttcgtgc tcactcatgt ggcaaagaag aaagcctccc ctgatgtgcc agtcttgctc 840 aatgttctcc accatgtcat tcctgcagcc ctcaatccca ttgtttatgg agtgcgaact 900 catgagatca agcaaggaat ccagagatta ctaaacaaag ggtga 945

<210> 1214 <211> 314 <212> PRT <213> Canis familiaris <400> 1214

Met Thr Thr His Gln Asn Gly Thr Ile Ser Ile Glu Ile Ser Asp Phe 1 5 10 15 Leu Leu Asn Cys Phe Val Arg Ser Pro Ser Trp Gln Leu Ser Phe Ser

20 25 30

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Leu Pro Leu 35 Ser Leu Leu Phe Leu Leu Ala Met Gly Ala Asn Gly Val 40 45 Leu Leu Ile Thr Ile Trp Leu Glu Ala Ser Leu His Glu Pro Met Tyr 50 55 60 Tyr Leu Leu Ser Ile Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr 65 70 75 80 Val Ile Pro Lys Val Leu Thr Ile Phe Trp Phe Asp Leu Lys Ser Ile 85 90 95 Asn Phe Tyr Ala Cys Phe Ile Gln Met Tyr Ile Met Asn Cys Phe Leu 100 105 110 Ala Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Glu Gln Phe 130 135 140 Val Ala Lys Ala Ala Ile Phe Ile Leu Ala Arg Asn Ala Ile Ser Thr 145 150 155 160 Leu Pro Ile Pro Ile Leu Ser Ser Arg Leu His Tyr Cys Gly Gly Asn 165 170 175 Val Ile Glu Asn Cys Ile Cys Ala Asn Met Ser Val Ser Lys Leu Ser 180 185 190 Cys Asp Asp Val Thr Ile Asn Arg Leu Tyr Gln Phe Ala Gly Gly Trp 195 200 205 Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Phe Leu Ser Tyr Ser Leu 210 215 220 Ile Leu Arg Ala Val Leu Arg Leu Lys Ala Glu Gly Ala Met Ala Lys 225 230 235 240

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Ala Leu Ser Thr Cys 245 Gly Thr Ile Leu Leu 260 Val Phe Ser Pro Asp 275 Val Pro Val Ala Ala 290 Leu Asn Pro Ile Gln 305 Gly Ile Gln Arg Leu 310

Ser His Phe Ile 250 Leu Val Leu Thr 265 His Val Leu Leu 280 Asn Val Leu Val 295 Tyr Gly Val Arg Leu Asn Lys Gly

Ile Leu Phe Phe 255 Ser Ala Lys Lys 270 Lys Ala His His 285 Val Ile Pro Thr 300 His Glu Ile Lys

<210> 1215 <211> 960 <212> DNA <213> Canis familiaris <400> 1215 atgacagcgc accaaaatgg ttagtcaggt ctcccagctg ctggccatgg gggccaatgg gagcccatgt actacctgct gttataccca aggtcctggc tgcttcattc agatgtacat gtcatggcct atgaccgcta actgatcaat ttgtagctag atgttcattc ctatcctctc tgtatctgtg ccaacctctc atataccagt taattgtggc tcgtatctct tcatcctaaa caccacttca gttgtggttt gaagttctgg ttgtccctgc tgttctcctg gtcaccatcc cagcatcctc tctctgctgg catcttctgg tttgatctca catgaattgc ttccttggca tgtggccatc tgccacccac ggctgctatg tttattttgg tgcccagctc cattattgtg tgtgtccaag ctctcctgtg ctggactctt ctgggctctg aactgttctt agacttaagg cagacttcct cctgaattgt ccctaagctt cctcttcctc agctggaggc ctctctgcat acatcatcct ctgcctgact ggtccatcag cttctctgcc tggagtcttg cacattcatg tgaggtactc ttccatcatc cgaggaatgc acttcttact gaaaaaatat aattgagaac ataatgtttt ccttaacaaa acctagtcct catcttcctc caaaaggggc agctgccaaa

120

180

240

300

360

420

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540

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660

720

Page 1372

069269_0225_SL.TXT gctctgagca gttttggttt aatgtcctac caggagatta catgcgggtc ttacccacat accatgtaat aagagggaat acacttcatt tgccaaaaaa tcctgcagct taggaaatta ctcatcctct aaagtttccc ctcaatccca ctgaggaggg tctttagcac ctgatattcc ttgtctatgg taacagagag catcctgctg catcttactt gatacgaacc attcaagtaa

780

840

900

960 <210> 1216 <211> 319 <212> PRT <213> Canis familiaris

<400> 1216 Met Thr Ala 1 His Gln Asn Gly Thr Thr Ser Val Val Val Ser Asp 15 Phe 5 10 Leu Leu Asn Cys Leu Val Arg Ser Pro Ser Trp Lys Phe Trp Leu Ser 20 25 30 Leu Pro Leu Ser Phe Leu Phe Leu Leu Ala Met Gly Ala Asn Gly Val 35 40 45 Leu Leu Val Thr Ile Gln Leu Glu Ala Ser Leu His Glu Pro Met Tyr 50 55 60 Tyr Leu Leu Ser Ile Leu Ser Leu Leu Asp Ile Ile Leu Cys Leu Thr 65 70 75 80 Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Ile 85 90 95 Ser Phe Ser Ala Cys Phe Ile Gln Met Tyr Ile Met Asn Cys Phe Leu 100 105 110 Gly Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Ser Ser Ile Ile Thr Asp Gln Phe 130 135 140 Val Ala Arg Ala Ala Met Phe Ile Leu Ala Arg Asn Ala Leu Leu Thr

Page 1373

0 6926 9_02 25_S L.TX T 145 150 155 160 Met Phe Ile Pro Ile Leu Ser Ala Gln Leu His Tyr Cys Gly Lys Asn 165 170 175 Ile Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser Lys Leu Ser 180 185 190 Cys Asp Asn Val Phe Leu Asn Lys Ile Tyr Gln Leu Ile Val Ala Trp 195 200 205 Thr Leu Leu Gly Ser Asp Leu Val Leu Ile Phe Leu Ser Tyr Leu Phe 210 215 220 Ile Leu Lys Thr Val Leu Arg Leu Lys Ala Lys Gly Ala Ala Ala Lys 225 230 235 240 Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser 245 250 255 Thr Ile Leu Leu Val Leu Val Phe Thr His Ile Ala Lys Lys Lys Val 260 265 270 Ser Pro Asp Ile Pro Ile Leu Leu Asn Val Leu His His Val Ile Pro 275 280 285 Ala Ala Leu Asn Pro Ile Val Tyr Gly Ile Arg Thr Gln Glu Ile Lys 290 295 300 Glu Gly Ile Arg Lys Leu Leu Arg Arg Val Thr Glu Arg Phe Lys 305 310 315

<210> 1217 <211> 948 <212> DNA <213> Canis familiaris <400> 1217 atgacagcac atccaaatgg tacaatctcc attgaggttt cagacttcct cctgaattgt tttgtcaggt ctcccagctg gaagctctgg ttgtccctgc ccctaagctt cctcttcctc

120

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069269_0225_SL.TXT ctggccatgg gggcgaatag tgttctcttg gtcaccatcc agctagaggc ctctcttcat gagcccatgt actacctgct gagcctcctt tccctgttag acattgttgt ctgcctcact gtcatcccca aggtcctggc catcttctgg tttgacctca agtccatcaa cttctatgcc tgctttatcc agatgtacat catgaattgc ttcctttcca tggagtcttg cacattcatg gtcatggcct atgaccgcta tgtggccatc tgccacccac tgaggtaccc atccatcatc acagaacaat ttgtagctaa ggctgctgcc tttattttgg ccagaaatgg gattttaaca gtgcctatcc caattctatc atcccgactc aattattgtg ggagaaatgt cattgagaat tgcatctgtg ccaatatgtc tgtctccaaa ctctcctgtg atgatgtcac catcaatcgc ctttaccagt ttgctgtagg atggacactg ctaggatctg acctcatcct catcttcctc tcctacagcc tcatactgcg agctgtgctg ggactcaagg cagagggtgc tatggccaag gccctgagca catgtggttc tcatttcatc cttatcctct tcttcagcac catccttctg gtcttcgtgc tcactcttgt ggtgaagaag aaagtctccc ctgatgtgcc agtcttgctc aatatcctcc atcatgtcat cttctcagcc ctcaacccca ttgtttatgg agtgcgaact caggagatca agcaaggaat ccagagatta ctgaagaaag gatggtag <210> 1218 <211> 315 <212> PRT <213> Canis familiaris

180

240

300

360

420

480

540

600

660

720

780

840

900

948 <400> 1218

Met Thr 1 Ala His Pro 5 Asn Gly Thr Ile Ser Ile Glu Val Ser Asp Phe 10 15 Leu Leu Asn Cys Phe Val Arg Ser Pro Ser Trp Lys Leu Trp Leu Ser 20 25 30 Leu Pro Leu Ser Phe Leu Phe Leu Leu Ala Met Gly Ala Asn Ser Val 35 40 45 Leu Leu Val Thr Ile Gln Leu Glu Ala Ser Leu His Glu Pro Met Tyr 50 55 60

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Tyr Leu 65 Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Val Cys Leu Thr 80 70 75 Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Lys Ser Ile 85 90 95 Asn Phe Tyr Ala Cys Phe Ile Gln Met Tyr Ile Met Asn Cys Phe Leu 100 105 110 Ser Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Glu Gln Phe 130 135 140 Val Ala Lys Ala Ala Ala Phe Ile Leu Ala Arg Asn Gly Ile Leu Thr 145 150 155 160 Val Pro Ile Pro Ile Leu Ser Ser Arg Leu Asn Tyr Cys Gly Arg Asn 165 170 175 Val Ile Glu Asn Cys Ile Cys Ala Asn Met Ser Val Ser Lys Leu Ser 180 185 190 Cys Asp Asp Val Thr Ile Asn Arg Leu Tyr Gln Phe Ala Val Gly Trp 195 200 205 Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Phe Leu Ser Tyr Ser Leu 210 215 220 Ile Leu Arg Ala Val Leu Gly Leu Lys Ala Glu Gly Ala Met Ala Lys 225 230 235 240 Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser 245 250 255 Thr Ile Leu Leu Val Phe Val Leu Thr Leu Val Val Lys Lys Lys Val 260 265 270

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Ser Pro Asp Val Pro Val Leu Leu Asn Ile 280 Leu His His 285 Val Ile Phe 275 Ser Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Gln Glu Ile Lys 290 295 300 Gln Gly Ile Gln Arg Leu Leu Lys Lys Gly Trp 305 310 315

<210> 1219 <211> 942 <212> DNA <213> Canis familiaris <400> 1219

atgacacctc acagaaatgg ctccactggg gtttcagagt tcctcctgaa ttgttttgtc 60 aggtccccca cttggcagct ctggttatcc ctgcccctca gcatcttgtt ccttgtggcc 120 atgggggcca atgctgttct cctgatcacc atctggctgg aggcctctct acaccagccc 180 atgtactacc tgctcagcct cctctccctc ctggacattg ttctctgcct cactgtcatc 240 cccaaggtcc tggtcatctt ctggtttgac ctcaagtcca tcagctttga tgcctgcttc 300 ctacagatgt acatcattaa ttgtttctat gccatggagt cctgcacatt tatggtcatg 360 gcctatgacc gctatgtggc catctgccac ccactgaggt acccatcaat catcactgaa 420 cgatttgtag ctaaggctgc tgcctttatt ttggccagaa atgggattgt aacagtgact 480 ctccccattc tatcatctcg actcaattat tgtgggagaa atattattga gaattgcatt 540 tgcgccaatt tgtctgtctc caagctctcc tgtgatgatg tcaccatcaa tcgcattctc 600 caatttgctg gaggctggac actgctagga tctgacctca tcctcatctt cctctcctac 660 ggccttatac tccgagctgt gctgagactc aaggcagagg gtgccatggc caaggccctg 720 agcacatgtg gttctcactt catccttatc ctcttcttca gcaccgtcct tctggtcttc 780 gtgctcactc atatgatgaa gaagaaagtc tcccctgatg tgccagtctt gctcaatgtc 840 ctccacaatg tcatccccgc agccctcaac cccattgttt atggagtgcg aacccaggag 900 atcaagcaag gaatccagag attactgaag aaggggtggt ag 942

<210> 1220

Page 1377

069269_0225_SL.TXT <211> 313 <212> PRT <213> Canis familiaris

<400> 1220 Glu Phe Leu 15 Leu Met 1 Thr Pro His Arg Asn Gly Ser 5 Thr Gly 10 Val Ser Asn Cys Phe Val Arg Ser Pro Thr Trp Gln Leu Trp Leu Ser Leu Pro 20 25 30 Leu Ser Ile Leu Phe Leu Val Ala Met Gly Ala Asn Ala Val Leu Leu 35 40 45 Ile Thr Ile Trp Leu Glu Ala Ser Leu His Gln Pro Met Tyr Tyr Leu 50 55 60 Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr Val Ile 65 70 75 80 Pro Lys Val Leu Val Ile Phe Trp Phe Asp Leu Lys Ser Ile Ser Phe 85 90 95 Asp Ala Cys Phe Leu Gln Met Tyr Ile Ile Asn Cys Phe Tyr Ala Met 100 105 110 Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Glu Arg Phe Val Ala 130 135 140 Lys Ala Ala Ala Phe Ile Leu Ala Arg Asn Gly Ile Val Thr Val Thr 145 150 155 160 Leu Pro Ile Leu Ser Ser Arg Leu Asn Tyr Cys Gly Arg Asn Ile Ile 165 170 175 Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser Lys Leu Ser Cys Asp 180 185 190

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Asp Val Thr Ile Asn Arg Ile Leu Gln Phe Ala Gly Gly Trp Thr Leu 195 200 205 Leu Gly Ser Asp Leu Ile Leu Ile Phe Leu Ser Tyr Gly Leu Ile Leu 210 215 220 Arg Ala Val Leu Arg Leu Lys Ala Glu Gly Ala Met Ala Lys Ala Leu 225 230 235 240 Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr Val 245 250 255 Leu Leu Val Phe Val Leu Thr His Met Met Lys Lys Lys Val Ser Pro 260 265 270 Asp Val Pro Val Leu Leu Asn Val Leu His Asn Val Ile Pro Ala Ala 275 280 285 Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Gln Glu Ile Lys Gln Gly 290 295 300 Ile Gln Arg Leu Leu Lys Lys Gly Trp

305 310 <210> 1221 <211> 690 <212> DNA <213> Canis familiaris <400> 1221

caggtcctgc tcatcttctg gttcaacatg aagaccatca gctttgcagg ctgctttctg 60 cagatgttca tcatgaatac attccttccc atggagtcct ccaccttcct ggtcatggcc 120 tatgaccgct atgtggccat ttgttatcct ctccgctacc catccatcat cactgaaaaa 180 tttgtcactt atgcagctgt cttcattgtc ttccgcaatt tgctggccac actacccaca 240 ccagttctgg ctgccaggct caactactgt gccagcaatg tggtggaaaa ctgtatctgt 300 gccaacattt ctgtagcaaa gctctcctgt gggaatatcc acctaaacaa gctctaccag 360 tttgtgagtg tttggtgtct actgggttct gacctggtgc tcatcttgct atcctactgc 420

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ttcatcttga gggctgttat gcgtctgcag tcaggaggtg cagccaccaa agccctgagt 480 acttgtggtt cccatctcat tcttatactt ttcttctata cattgctact agtcttcatc 540 tttacaaaca aggcaagaaa gaaggtgccc ttagaggtac ccattcttct taatgtctta 600 caccacctca ttccaccagc tctgaatccc attgtttatg gagtacgaac ccaggaaatc 660 aaacaaggga ttatcaagct actcaagtac 690

<210> 1222 <211> 230 <212> PRT <213> Canis familiaris

<400> 1222 Phe Trp Phe Asn Met 10 Lys Thr Ile Ser Phe 15 Ala Gln Val 1 Leu Leu Ile 5 Gly Cys Phe Leu Gln Met Phe Ile Met Asn Thr Phe Leu Pro Met Glu 20 25 30 Ser Ser Thr Phe Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 35 40 45 Tyr Pro Leu Arg Tyr Pro Ser Ile Ile Thr Glu Lys Phe Val Thr Tyr 50 55 60 Ala Ala Val Phe Ile Val Phe Arg Asn Leu Leu Ala Thr Leu Pro Thr 65 70 75 80 Pro Val Leu Ala Ala Arg Leu Asn Tyr Cys Ala Ser Asn Val Val Glu 85 90 95 Asn Cys Ile Cys Ala Asn Ile Ser Val Ala Lys Leu Ser Cys Gly Asn 100 105 110 Ile His Leu Asn Lys Leu Tyr Gln Phe Val Ser Val Trp Cys Leu Leu 115 120 125 Gly Ser Asp Leu Val Leu Ile Leu Leu Ser Tyr Cys Phe Ile Leu Arg 130 135 140

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Ala Val 145 Met Arg Leu Gln Ser Gly Gly Ala Ala Thr Lys Ala Leu Ser 150 155 160 Thr Cys Gly Ser His Leu Ile Leu Ile Leu Phe Phe Tyr Thr Leu Leu 165 170 175 Leu Val Phe Ile Phe Thr Asn Lys Ala Arg Lys Lys Val Pro Leu Glu 180 185 190 Val Pro Ile Leu Leu Asn Val Leu His His Leu Ile Pro Pro Ala Leu 195 200 205 Asn Pro Ile Val Tyr Gly Val Arg Thr Gln Glu Ile Lys Gln Gly Ile 210 215 220 Ile Lys Leu Leu Lys Tyr

225 230 <210> 1223 <211> 306 <212> DNA <213> Canis familiaris <400> 1223

aacaacacag gcacccaagt gactgaattc ctgatgatct gcttcccagg attgcaggac 60 acacagcatt ggctctctgt agtcctggct ccccttctgg ttttggccct tggggctaac 120 tttgtgttgt tactcaccat ccagcaggag acatctctgc atgaacccat gtactacctg 180 cttgccatcc tttccatgct ggacatcatc ctttgcctca ctgtcattcc taaggttaga 240 cccccctcta gattcacttc caggtactca gtcatctatc tctgaatagt attgttttgt 300 tgctat 306

<210> 1224 <211> 94 <212> PRT <213> Canis familiaris <400> 1224

Asn Asn Thr Gly Thr Gln Val Thr Glu Phe Leu Met Ile Cys Phe Pro

Page 1381

0 6926 >9_02 25_S iL.TX T 1 5 10 15 Gly Leu Gln Asp Thr Gln His Trp Leu Ser Val Val Leu Ala Pro Leu 20 25 30 Leu Val Leu Ala Leu Gly Ala Asn Phe Val Leu Leu Leu Thr Ile Gln 35 40 45 Gln Glu Thr Ser Leu His Glu Pro Met Tyr Tyr Leu Leu Ala Ile Leu 50 55 60 Ser Met Leu Asp Ile Ile Leu Cys Leu Thr Val Ile Pro Lys Val Arg 65 70 75 80 Pro Pro Ser Arg Phe Thr Ser Arg Tyr Ser Val Ile Tyr Leu 85 90

<210> 1225 <211> 960 <212> DNA <213> Canis familiaris <400> 1225

atgatcagaa cactttacat ggcaccaccc agcaactact ccactgctcc agtttctgaa 60 ttcttcctca tctgcttccc taactaccag agttggcagc actggctgtc cctgcccctc 120 agcctcctct tcctcctggc catgggggcc aacgccaccc tcttgattac tatccggctg 180 gaggcctctc tgcatgagcc catgtactac ctgcttggcc tcctctccct gctggacatc 240 gtgctctccc tcactgtcat ccccaaggtc ctggccatct tctggtttga tctgaggtct 300 atcagcttct ctgcctgctt cctccagatg ttcatcatga acagtttcct ccccatggag 360 tcctgcacat tcatggtcat ggcctatgac cgctatgtgg ccatctgcca cccattacga 420 tactcatcta tcattactga ccaatttgta gttagggctg ccatctttgt tgtggcccgg 480 aatggccttc ttactatgcc tatccccata ctttcttccc ggctcagata ctgtgcagag 540 aacatcatca agaactgtat ctgtactaac ttgtctgtat ccaaactttc ctgtgatgac 600 atcaccttca atcaactcta ccagttcgtg gcaggctgga ctctactggg ctctgacctc 660 atcctaatta ttctgtccta ctccttcatc ctgaaagctg tgctaaggat caaggctgag 720

Page 1382

069269_0225_SL.TXT ggtgctatgg ccaaagctct aggcacttgt ggttctcact tcatcctcat cctcttcttt agcacagtcc tgttggttct agtcatcact aacctggcca ggaagagaat tcccccagat gtccccatct tgctcaacat cttgcaccac ctcatccccc cagctctgaa ccccattgtt tatggtgtga gaaccaagga tatcaagcaa ggaatccaga agctacttag aagattgtaa

780

840

900

960 <210> 1226 <211> 319 <212> PRT <213> Canis familiaris <400> 1226

Met Ile Arg Thr 1 Leu 5 Tyr Met Ala Pro Pro Ser Asn Tyr Ser Thr Ala 10 15 Pro Val Ser Glu Phe Phe Leu Ile Cys Phe Pro Asn Tyr Gln Ser Trp 20 25 30 Gln His Trp Leu Ser Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met 35 40 45 Gly Ala Asn Ala Thr Leu Leu Ile Thr Ile Arg Leu Glu Ala Ser Leu 50 55 60 His Glu Pro Met Tyr Tyr Leu Leu Gly Leu Leu Ser Leu Leu Asp Ile 65 70 75 80 Val Leu Ser Leu Thr Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe 85 90 95 Asp Leu Arg Ser Ile Ser Phe Ser Ala Cys Phe Leu Gln Met Phe Ile 100 105 110 Met Asn Ser Phe Leu Pro Met Glu Ser Cys Thr Phe Met Val Met Ala 115 120 125 Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Ser Ser Ile 130 135 140

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Ile Thr Asp Gln Phe Val Val Arg Ala Ala Ile Phe Val Val Ala Arg 145 150 155 160 Asn Gly Leu Leu Thr Met Pro Ile Pro Ile Leu Ser Ser Arg Leu Arg 165 170 175 Tyr Cys Ala Glu Asn Ile Ile Lys Asn Cys Ile Cys Thr Asn Leu Ser 180 185 190 Val Ser Lys Leu Ser Cys Asp Asp Ile Thr Phe Asn Gln Leu Tyr Gln 195 200 205 Phe Val Ala Gly Trp Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Ile 210 215 220 Leu Ser Tyr Ser Phe Ile Leu Lys Ala Val Leu Arg Ile Lys Ala Glu 225 230 235 240 Gly Ala Met Ala Lys Ala Leu Gly Thr Cys Gly Ser His Phe Ile Leu 245 250 255 Ile Leu Phe Phe Ser Thr Val Leu Leu Val Leu Val Ile Thr Asn Leu 260 265 270 Ala Arg Lys Arg Ile Pro Pro Asp Val Pro Ile Leu Leu Asn Ile Leu 275 280 285 His His Leu Ile Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Arg 290 295 300 Thr Lys Asp Ile Lys Gln Gly Ile Gln Lys Leu Leu Arg Arg Leu 305 310 315 <210> 1227 <211> 942 <212> DNA <213> Canis familiaris <400> 1227 atggcaccac caagcaacta ctccactgct ccagtctctg aattcctcct catctgcttc 60

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cctaactacc agagttggca gcactggctg tccctgcccc tcagcctcct cttcctcctg 120 gccatggggg ccaatgccac cctcttaatc actatccggc tggaggcctc tctgcacgag 180 cccatgtact acctgctcag cctcctctcc ctgctggaca tcgtgctctg cctcactgtc 240 atccccaagg tcctggccat cttctggttt gatctgaggt ccatcagctt ctctgcctgc 300 ttcctccaga tgttcatcat gaattgcttc cttgccatgg agtcctgcac attcatggtc 360 atggcctatg accgctatgt ggccatctgc cacccactga ggtacccatc catcatcact 420 gaccaatttg tggttagagc taccatattt attgtggtca ggaatggcct cttttttctt 480 cctgttccag tactttcttc ccggctcaga tactgtgcag agaacatcat caagaactgt 540 atatgcacca acctgtctgt gtccaaactc tcctgtgatg acatcacctt caatcggctc 600 taccagtttg tggcaggctg gaccctattg ggctctgacc tcatcctaat tattctgtcc 660 tactccttca tcctgaaagc tgtgctaagg atcaaggctg agggtgctac agccaaggcc 720 ctgagcacgt gtggttccca cttcatcctc attctcttct tcagcacagt cttgttggtt 780 ctggtcatca ctaacctggc caggaagaga attcctccag atgtccccat cctactcaac 840 atcctgcacc acctcattcc cccagctctg aaccctattg tttatggtgt gagaaccaac 900 gagatcaagc aaggaatgca gaagctgctg agaaggttgt aa 942 <210> 1228 <211> 313 <212> PRT <213> Canis familiaris <400> 1228 Met Ala Pro Pro Ser Asn Tyr Ser Thr Ala Pro Val Ser Glu Phe Leu 1 5 10 15 Leu Ile Cys Phe Pro Asn Tyr Gln Ser Trp Gln His Trp Leu Ser Leu 20 25 30 Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala Asn Ala Thr Leu 35 40 45 Leu Ile Thr Ile Arg Leu Glu Ala Ser Leu His Glu Pro Met Tyr Tyr 50 55 60

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Leu Leu 65 Ser Leu Leu Ser 70 Leu Leu Asp Ile Val 75 Leu Cys Leu Thr Val 80 Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Ile Ser 85 90 95 Phe Ser Ala Cys Phe Leu Gln Met Phe Ile Met Asn Cys Phe Leu Ala 100 105 110 Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asp Gln Phe Val 130 135 140 Val Arg Ala Thr Ile Phe Ile Val Val Arg Asn Gly Leu Phe Phe Leu 145 150 155 160 Pro Val Pro Val Leu Ser Ser Arg Leu Arg Tyr Cys Ala Glu Asn Ile 165 170 175 Ile Lys Asn Cys Ile Cys Thr Asn Leu Ser Val Ser Lys Leu Ser Cys 180 185 190 Asp Asp Ile Thr Phe Asn Arg Leu Tyr Gln Phe Val Ala Gly Trp Thr 195 200 205 Leu Leu Gly Ser Asp Leu Ile Leu Ile Ile Leu Ser Tyr Ser Phe Ile 210 215 220 Leu Lys Ala Val Leu Arg Ile Lys Ala Glu Gly Ala Thr Ala Lys Ala 225 230 235 240 Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr 245 250 255 Val Leu Leu Val Leu Val Ile Thr Asn Leu Ala Arg Lys Arg Ile Pro 260 265 270

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Pro Asp Val Pro Ile Leu Leu Asn Ile Leu His His Leu Ile Pro Pro 275 280 285 Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Asn Glu Ile Lys Gln 290 295 300 Gly Met Gln Lys Leu Leu Arg Arg Leu 305 310

<210> 1229 <211> 945 <212> DNA <213> Canis familiaris <400> 1229

atggcttcac ccagcaacta ctccactgct ccagtctccg aattcctcct catctgcttt 60 cctaactacc agagttggca gcactggctg tccctgcccc tcagcctcct cttcctcctg 120 gccatggggg ccaacgccac cctcttgatc actatccggc tggaggcctc tctgcatgag 180 cccatgtact acctgctcag cctcctctcc ctgctggaca tcgtgctctg cctcactgtc 240 atccccaagg tcctggccat cttctggttt gatctgaggt ccatcagctt ctctgcctgc 300 ttcctccaga tgttcatcat gaacagtttc ctccccatgg agtcttgcac attcatggtc 360 atggcctatg accgctatgt ggccatctgc cacccactga ggtatccatc catcatcact 420 aaccaatttg tggccaaagc tagtgctttc attgtcaccc ggaatgccct tctcactgca 480 cctattccta ttctcaccgc ccagctccat tattgtggga aaaatgtcat tgagaactgc 540 atctgtgcca acttgtctgt gtccaggcta tcctgtgaca atttcaccct taacagaatc 600 taccaatttg tggctggttg gactttactg ggctcagatt tcatcctcat cttcctctcc 660 tacaccttta tcctaagagc tgtgcttagg ttcaaggctg agggggctgc tgtcaaagct 720 ctgagcacat gtggctctca cttcatcctc atcctgttct tcagcaccat cctgctggtt 780 gttgtgttaa caaatgtggc cagaaagagt gtccctatgg acatcctcat cttgctcaat 840 gtccttcatc acctcatacc tcctgccttg aaccctattg tatatggagt tcggaccaaa 900 gagataaaac aaggaatgaa taaattgctg tggaaaagga tgtga 945

Page 1387

069269_0225_SL.TXT <210> 1230 <211> 314 <212> PRT <213> Canis familiaris

<400> 1230 Ser Glu Phe 15 Leu Met 1 Ala Ser Pro Ser Asn Tyr Ser 5 Thr Ala 10 Pro Val Leu Ile Cys Phe Pro Asn Tyr Gln Ser Trp Gln His Trp Leu Ser Leu 20 25 30 Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala Asn Ala Thr Leu 35 40 45 Leu Ile Thr Ile Arg Leu Glu Ala Ser Leu His Glu Pro Met Tyr Tyr 50 55 60 Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr Val 65 70 75 80 Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Ile Ser 85 90 95 Phe Ser Ala Cys Phe Leu Gln Met Phe Ile Met Asn Ser Phe Leu Pro 100 105 110 Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asn Gln Phe Val 130 135 140 Ala Lys Ala Ser Ala Phe Ile Val Thr Arg Asn Ala Leu Leu Thr Ala 145 150 155 160 Pro Ile Pro Ile Leu Thr Ala Gln Leu His Tyr Cys Gly Lys Asn Val 165 170 175 Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser Arg Leu Ser Cys 180 185 190

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Asp Asn Phe Thr Leu Asn Arg Ile Tyr Gln Phe Val Ala Gly Trp Thr 195 200 205 Leu Leu Gly Ser Asp Phe Ile Leu Ile Phe Leu Ser Tyr Thr Phe Ile 210 215 220 Leu Arg Ala Val Leu Arg Phe Lys Ala Glu Gly Ala Ala Val Lys Ala 225 230 235 240 Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr 245 250 255 Ile Leu Leu Val Val Val Leu Thr Asn Val Ala Arg Lys Ser Val Pro 260 265 270 Met Asp Ile Leu Ile Leu Leu Asn Val Leu His His Leu Ile Pro Pro 275 280 285 Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys Glu Ile Lys Gln 290 295 300 Gly Met Asn Lys Leu Leu Trp Lys Arg Met

305 310 <210> 1231 <211> 945 <212> DNA <213> Canis familiaris <400> 1231

atgacatcac ccagcaacta ctctactgct ccagtctccg aattcctcct catctgcttt 60 cctaactacc agagttggca gcactggctg tctctgcccc tcagcctcct cttcctcctg 120 gccatggggg ccaacaccac cctcttgatc actatctggc tggaggcctc tctgcacgag 180 cccatgtact acctgctcag cctcctctcc ctgctggaca ttgtgctctg cctcactgtc 240 atccccaagg tcctggccat cttctggttt gatctgaggt ccatcagctt ctctgcctgc 300 ttcctccaga tgttcatcat gaacagtttc ctccccatgg agtcctgcac attcatggtc 360

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atggcctatg accgctatgt ggccatctgc cacccactga ggtatccatc catcatcact 420 gaccaatttg tggccaaagc tagtgttttc attgtgattc ggaatgcttt gctgctttca 480 cctgtaccca ttctcaccgc ccagctccat tattgtggga aaaatgtcat tgagaactgc 540 atctgtgcca acttgtctgt gtccaagcta tcctgtgaca atttcaccct taacagaatc 600 taccaatttg tggttgtttg gactttactg ggctcagatt tcatcctcat cttcctctcc 660 tacaccttta tcctaagagc tgtgcttagg ttcaaggatg agggggctgc tgccaaagct 720 ctgagcacat gtggctctca cttcatcctc atcctgttct tcagcaccat cctgctggtt 780 gttgtgttga caaatgtggc cagaaagagt gtccccatgg acatccccat cttgctcaat 840 gtcctccatc acctcatacc tcctgccttg aaccctattg tatatgggtt tcgaaccaaa 900 gagttaaagc aggggtgtca gaagttattg cgatgggggc <210> 1232 <211> 314 <212> PRT <213> Canis familiaris <400> 1232 tttaa 945 Met Thr Ser Pro Ser Asn Tyr Ser Thr Ala Pro 1 5 10 Val Ser Glu Phe Leu 15 Leu Ile Cys Phe Pro Asn Tyr Gln Ser Trp Gln 20 25 His Trp Leu 30 Ser Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly 35 40 Ala Asn Thr 45 Thr Leu Leu Ile Thr Ile Trp Leu Glu Ala Ser Leu His 50 55 Glu Pro Met 60 Tyr Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val 65 70 75 Leu Cys Leu Thr Val 80 Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp 85 90 Leu Arg Ser Ile Ser 95 Phe Ser Ala Cys Phe Leu Gln Met Phe Ile Met Asn Ser Phe Leu Pro

Page 1390

100

069269_0225_SL.TXT 105 110

Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asp Gln Phe Val 130 135 140 Ala Lys Ala Ser Val Phe Ile Val Ile Arg Asn Ala Leu Leu Leu Ser 145 150 155 160 Pro Val Pro Ile Leu Thr Ala Gln Leu His Tyr Cys Gly Lys Asn Val 165 170 175 Ile Glu Asn Cys Ile Cys Ala Asn Leu Ser Val Ser Lys Leu Ser Cys 180 185 190 Asp Asn Phe Thr Leu Asn Arg Ile Tyr Gln Phe Val Val Val Trp Thr 195 200 205 Leu Leu Gly Ser Asp Phe Ile Leu Ile Phe Leu Ser Tyr Thr Phe Ile 210 215 220 Leu Arg Ala Val Leu Arg Phe Lys Asp Glu Gly Ala Ala Ala Lys Ala 225 230 235 240 Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr 245 250 255 Ile Leu Leu Val Val Val Leu Thr Asn Val Ala Arg Lys Ser Val Pro 260 265 270 Met Asp Ile Pro Ile Leu Leu Asn Val Leu His His Leu Ile Pro Pro 275 280 285 Ala Leu Asn Pro Ile Val Tyr Gly Phe Arg Thr Lys Glu Leu Lys Gln 290 295 300

Gly Cys Gln Lys Leu Leu Arg Trp Gly Leu

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305

310 <210> 1233 <211> 945 <212> DNA <213> Canis familiaris <400> 1233

atgccaaact tccagaatac cacatctact tccatcattt tcctgctaac tggtgttccc 60 gggctggaag ccttccacac ctggatctcc attcccttct gctttctcta cataaccgcc 120 ctctcaggaa acagcctgat cctctttgcc attgtcactc agcccagcct ccacgaaccc 180 atgtattatt tcctttccat gctgtctacc actgacctcg gcctatccat atccaccctg 240 gtcaccatgt tgggtatatt ctggttcaat gccagggaga tcagctttaa tgcttgcttg 300 tcacagatgt tctttattaa actcttcact gtcatggaat cctcggtgct gttggccatg 360 gcctttgatc gttttgtggc catctctaat ccactcaggt atgccaccat tttaaccgat 420 tccagaatag ctcaaattgg agtgacaatt gtcatcaggg gaacactaat gctgacacca 480 atggtagcac ttcttaaaag actgtccttc tgccgcagcc acgtgctcca ccactcctac 540 tgcttccacc ctgatgtgat gaagctctcg tgcacagaca ccaggatcaa caatgcagtt 600 gggctgacag ccatgatctc tactgttggt gtggactcaa tcctcatcct cctttcttac 660 attttgatta ttaagactgt cctcagcatt gcatccccag aagagaggaa gaaagccttc 720 agcacatgta tctcccatat tggggctgtt gctattttct attttccatt gatcagtctg 780 tcctttgttc acagatttgg aaaacgagct ccagcctatg ttcatacaat gattgctaac 840 acttacctct tgatccctcc tgtaatgaac cccatcatct acagcgtgaa gacaaaacag 900 atacgcagag ctgtgataaa aattctctat tccaaagaca tgtag 945

<210> 1234 <211> 314 <212> PRT <213> Canis familiaris <400> 1234

Met Pro Asn Phe Gln Asn Thr Thr Ser Thr Ser Ile Ile Phe Leu Leu 1 5 10 15

Page 1392

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Thr Gly Val Pro 20 Gly Leu Glu Ala Phe His Thr Trp Ile Ser Ile Pro 25 30 Phe Cys Phe Leu Tyr Ile Thr Ala Leu Ser Gly Asn Ser Leu Ile Leu 35 40 45 Phe Ala Ile Val Thr Gln Pro Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ser Thr Thr Asp Leu Gly Leu Ser Ile Ser Thr Leu 65 70 75 80 Val Thr Met Leu Gly Ile Phe Trp Phe Asn Ala Arg Glu Ile Ser Phe 85 90 95 Asn Ala Cys Leu Ser Gln Met Phe Phe Ile Lys Leu Phe Thr Val Met 100 105 110 Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Ser Asn Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asp Ser Arg Ile Ala 130 135 140 Gln Ile Gly Val Thr Ile Val Ile Arg Gly Thr Leu Met Leu Thr Pro 145 150 155 160 Met Val Ala Leu Leu Lys Arg Leu Ser Phe Cys Arg Ser His Val Leu 165 170 175 His His Ser Tyr Cys Phe His Pro Asp Val Met Lys Leu Ser Cys Thr 180 185 190 Asp Thr Arg Ile Asn Asn Ala Val Gly Leu Thr Ala Met Ile Ser Thr 195 200 205 Val Gly Val Asp Ser Ile Leu Ile Leu Leu Ser Tyr Ile Leu Ile Ile 210 215 220

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Lys 225 Thr Val Leu Ser Ile 230 Ala Ser Pro Glu Glu 235 Arg Lys Lys Ala Phe 240 Ser Thr Cys Ile Ser His Ile Gly Ala Val Ala Ile Phe Tyr Phe Pro 245 250 255 Leu Ile Ser Leu Ser Phe Val His Arg Phe Gly Lys Arg Ala Pro Ala 260 265 270 Tyr Val His Thr Met Ile Ala Asn Thr Tyr Leu Leu Ile Pro Pro Val 275 280 285 Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Arg Arg Ala 290 295 300 Val Ile Lys Ile Leu Tyr Ser Lys Asp Met 305 310

<210> 1235 <211> 954 <212> DNA <213> Canis familiaris <400> 1235

atgatgacct ttagtaattc tagctggagg ctactccagc cttctttttt tctgatgggc 60 atccccggtt tagaggaaag ccagcactgg atagcattgc cactgtgtgt cctttatgtc 120 cttgctgtaa tgggcaatgt caccgtcatc ttcatcatct ggactgactc atccttgcac 180 cagccgatgt acctctttct ggccatgcta tctggcattg acctggtgct ggcctcctcc 240 actgcaccca aagcccttgc ggtgctcctg gctcatgccc atgagattgg gtacactttc 300 tgcctgatcc agatgttctt catccatgcg ttctcttcca tggagtcagg ggtacttgtg 360 gctatggctc tggatcgcta tgtagccatt tgtcaccctc tgcatcattc caccatcttg 420 cgtccgggga tcatcgggcg cattgggatg gcagtgctgg tgcgggggtt agtcctcctc 480 ctccccttcc ctatcctgtt gcagagactc ctcttctgcc gggccaccat cataggccat 540 gcctattgtg aacatatggc tgttgtaaaa cttgcctgct cagaaaccac agtgaaccga 600 gcttatgggt tggcagtggc cctgcttgtg gttgggctag atgtcgtggc cattggtatt 660

Page 1394

069269_0225_SL.TXT tcctatgccc tcatcctgca gacagtgctg aaggtaccag ggggtgaggc ccgacttaag gcctttagca catgtgggtc tcatatttgt gttatcctga tcttctatgt tcctggaatg ttttccttcc tcacacatcg ctttggccac catgtacccc accacgtcca tgttcttctg gccacactct acctccttgt gccacctgca ctcaatcctc ttgtctatgg ggtgaagact cgacagatcc gccagcgagt acttagagtt ttctccctaa aaggattgat ctga

720

780

840

900

954 <210> 1236 <211> 317 <212> PRT <213> Canis familiaris <400> 1236

Met Met Thr Phe 1 Ser 5 Asn Ser Ser Trp Arg Leu Leu Gln Pro Ser Phe 10 15 Phe Leu Met Gly Ile Pro Gly Leu Glu Glu Ser Gln His Trp Ile Ala 20 25 30 Leu Pro Leu Cys Val Leu Tyr Val Leu Ala Val Met Gly Asn Val Thr 35 40 45 Val Ile Phe Ile Ile Trp Thr Asp Ser Ser Leu His Gln Pro Met Tyr 50 55 60 Leu Phe Leu Ala Met Leu Ser Gly Ile Asp Leu Val Leu Ala Ser Ser 65 70 75 80 Thr Ala Pro Lys Ala Leu Ala Val Leu Leu Ala His Ala His Glu Ile 85 90 95 Gly Tyr Thr Phe Cys Leu Ile Gln Met Phe Phe Ile His Ala Phe Ser 100 105 110 Ser Met Glu Ser Gly Val Leu Val Ala Met Ala Leu Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu His His Ser Thr Ile Leu Arg Pro Gly Ile 130 135 140

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Ile Gly Arg Ile Gly Met Ala Val Leu Val Arg Gly Leu Val Leu Leu 145 150 155 160 Leu Pro Phe Pro Ile Leu Leu Gln Arg Leu Leu Phe Cys Arg Ala Thr 165 170 175 Ile Ile Gly His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala 180 185 190 Cys Ser Glu Thr Thr Val Asn Arg Ala Tyr Gly Leu Ala Val Ala Leu 195 200 205 Leu Val Val Gly Leu Asp Val Val Ala Ile Gly Ile Ser Tyr Ala Leu 210 215 220 Ile Leu Gln Thr Val Leu Lys Val Pro Gly Gly Glu Ala Arg Leu Lys 225 230 235 240 Ala Phe Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Ile Phe Tyr 245 250 255 Val Pro Gly Met Phe Ser Phe Leu Thr His Arg Phe Gly His His Val 260 265 270 Pro His His Val His Val Leu Leu Ala Thr Leu Tyr Leu Leu Val Pro 275 280 285 Pro Ala Leu Asn Pro Leu Val Tyr Gly Val Lys Thr Arg Gln Ile Arg 290 295 300 Gln Arg Val Leu Arg Val Phe Ser Leu Lys Gly Leu Ile 305 310 315 <210> 1237 <211> 966 <212> DNA <213> Canis familiaris <400> 1237 atggatatca ccctgagtat aaccaatagc tccaggtttc aagtacctga attcatcctc 60

Page 1396

069269_0225_SL.TXT ctggggctcc caggcattca tgagtggcag cactggctct ctctgcccct ggctctgctc tacatcttag ctctttgtgc caacatcctc atcttaatca ccatccaaca tgagccttcc ctgcaccagc ccatgtattg gttccttggt gtcttggcta tagtggacat tggcctggct accactatca tacccaagat cctggccatt ctctggtttg atgccaaggc catcagcctc cctgagtgct ttgctcagat ctatgccatc cactctttta tgggcatgga gtcaggcatc ttcctctgca tggctatcga tagatatgta gccatttcct acccccttcg gtacccctcc atactcactg aggcttttgt gatcaaagtc acactgttca tggtgctcag gaatggcctg ttgaccctcc cagtgcctgt attggctgcc cagagacact actgctccag gaacgaaatt gaccactgtc tatgctctaa tttgggggtc actagtctgg cctgtgatga catcactatt aacagatttt accagttggc cttggtatgg gttatggttg ggggtgacat gggtctggtc tttgcttcct atgctttgat tattcgctca gtgctgaggc tgaactctgc taaagcaaca tcaaaggccc tgagtacctg cagctcccat ctcatcctca ttctcttttt ctacacggct gttattgtgg tgtctgtcac ccagctggca ggaagaaagg tcccccttat ccctgctctc ttcaatgtgc tgcacagtat catgccccca gcctttaacc ccatggttta tgccctccgg acccaggagc tgagagtggg cttccagagg gtgcttggtt tgggtgacaa tgtgtccagg aagtga <210> 1238 <211> 321 <212> PRT <213> Canis familiaris

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966 <400> 1238

Met 1 Asp Ile Thr Leu Ser Ile Thr Asn Ser Ser Arg Phe Gln Val Pro 5 10 15 Glu Phe Ile Leu Leu Gly Leu Pro Gly Ile His Glu Trp Gln His Trp 20 25 30 Leu Ser Leu Pro Leu Ala Leu Leu Tyr Ile Leu Ala Leu Cys Ala Asn 35 40 45

Page 1397

Ile Leu 50 Ile Leu Ile Thr Ile 55 069269_0225_SL.TXT Gln His Glu Pro Ser Leu 60 His Gln Pro Met Tyr Trp Phe Leu Gly Val Leu Ala Ile Val Asp Ile Gly Leu Ala 65 70 75 80 Thr Thr Ile Ile Pro Lys Ile Leu Ala Ile Leu Trp Phe Asp Ala Lys 85 90 95 Ala Ile Ser Leu Pro Glu Cys Phe Ala Gln Ile Tyr Ala Ile His Ser 100 105 110 Phe Met Gly Met Glu Ser Gly Ile Phe Leu Cys Met Ala Ile Asp Arg 115 120 125 Tyr Val Ala Ile Ser Tyr Pro Leu Arg Tyr Pro Ser Ile Leu Thr Glu 130 135 140 Ala Phe Val Ile Lys Val Thr Leu Phe Met Val Leu Arg Asn Gly Leu 145 150 155 160 Leu Thr Leu Pro Val Pro Val Leu Ala Ala Gln Arg His Tyr Cys Ser 165 170 175 Arg Asn Glu Ile Asp His Cys Leu Cys Ser Asn Leu Gly Val Thr Ser 180 185 190 Leu Ala Cys Asp Asp Ile Thr Ile Asn Arg Phe Tyr Gln Leu Ala Leu 195 200 205 Val Trp Val Met Val Gly Gly Asp Met Gly Leu Val Phe Ala Ser Tyr 210 215 220 Ala Leu Ile Ile Arg Ser Val Leu Arg Leu Asn Ser Ala Lys Ala Thr 225 230 235 240 Ser Lys Ala Leu Ser Thr Cys Ser Ser His Leu Ile Leu Ile Leu Phe 245 250 255

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Phe Tyr Thr Ala 260 Val Ile Val 069269_0225_SL.TXT Val Ser Val Thr Gln Leu 265 Ala 270 Gly Arg Lys Val Pro Leu Ile Pro Ala Leu Phe Asn Val Leu His Ser Ile Met 275 280 285 Pro Pro Ala Phe Asn Pro Met Val Tyr Ala Leu Arg Thr Gln Glu Leu 290 295 300 Arg Val Gly Phe Gln Arg Val Leu Gly Leu Gly Asp Asn Val Ser Arg 305 310 315 320

Lys <210> 1239 <211> 948 <212> DNA <213> Canis familiaris <400> 1239 atgatgacct ttagtaattc tagctggagg ctactccagc cttctttttt tctgatgggc 60 atccccggtt tagaggaaag ccagcactgg atagcattgc cactgtgtgt cctttatgtc 120 cttgctgtaa tgggcaatgt caccatcatc ttcatcatct ggactgactc atccttgcac 180 cagccgatgt acctctttct ggccatgcta tctggcattg acctggtgct ggcctcctcc 240 actgcaccca aaacccttgc ggtgctcctg gctcatgccc atgagattgg gtacactttc 300 tgcctgatcc agatgttctt catccatgcg ttctcttcca tggagtcagg ggtacttgtg 360 gccatggctc tggatcgcta tgtagccatt tgtcaccctc tgcatcattc caccatcttg 420 catccgggga tcatcgggcg cattgggatg gcagtgctgg tgcgggggtt agtcctcctc 480 ctccccttcc ctatcctgtt gcagagactc ctcttctgcc gggccaccat cataggccat 540 gcctattgtg aacatatggc tgttgtaaaa cttgcctgct cagaaaccac agtgaaccga 600 gcttatgggt tggcagtggc cctgcttgtg gttgggctag atgtcgtggc cattggtatt 660 tcctatgcct tcatcctgca gacagtgctg aaggtaccag ggggtgaggc ccgacttaag 720 gcctttagca catgtgggtc tcatatttgt gttatcctga tcttctatgt tcctggaata 780

Page 1399

069269_0225_SL.TXT ttctccttcc tcacacatcg ttttggccac catgtacccc accacgtcca tgttcttctg gccacactct acctccttgt gccacctgca ctcaatcctc ttgtctatgg ggtgaagact caacagatcc gccagcgagt acttagggtt ttctccctaa aaggatag

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948 <210> 1240 <211> 315 <212> PRT <213> Canis familiaris <400> 1240

Met Met 1 Thr Phe Ser Asn Ser Ser Trp Arg Leu Leu Gln Pro Ser Phe 5 10 15 Phe Leu Met Gly Ile Pro Gly Leu Glu Glu Ser Gln His Trp Ile Ala 20 25 30 Leu Pro Leu Cys Val Leu Tyr Val Leu Ala Val Met Gly Asn Val Thr 35 40 45 Ile Ile Phe Ile Ile Trp Thr Asp Ser Ser Leu His Gln Pro Met Tyr 50 55 60 Leu Phe Leu Ala Met Leu Ser Gly Ile Asp Leu Val Leu Ala Ser Ser 65 70 75 80 Thr Ala Pro Lys Thr Leu Ala Val Leu Leu Ala His Ala His Glu Ile 85 90 95 Gly Tyr Thr Phe Cys Leu Ile Gln Met Phe Phe Ile His Ala Phe Ser 100 105 110 Ser Met Glu Ser Gly Val Leu Val Ala Met Ala Leu Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu His His Ser Thr Ile Leu His Pro Gly Ile 130 135 140 Ile Gly Arg Ile Gly Met Ala Val Leu Val Arg Gly Leu Val Leu Leu 145 150 155 160

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Leu Pro Phe Pro Ile Leu Leu Gln Arg Leu Leu Phe Cys Arg Ala Thr 165 170 175 Ile Ile Gly His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala 180 185 190 Cys Ser Glu Thr Thr Val Asn Arg Ala Tyr Gly Leu Ala Val Ala Leu 195 200 205 Leu Val Val Gly Leu Asp Val Val Ala Ile Gly Ile Ser Tyr Ala Phe 210 215 220 Ile Leu Gln Thr Val Leu Lys Val Pro Gly Gly Glu Ala Arg Leu Lys 225 230 235 240 Ala Phe Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Ile Phe Tyr 245 250 255 Val Pro Gly Ile Phe Ser Phe Leu Thr His Arg Phe Gly His His Val 260 265 270 Pro His His Val His Val Leu Leu Ala Thr Leu Tyr Leu Leu Val Pro 275 280 285 Pro Ala Leu Asn Pro Leu Val Tyr Gly Val Lys Thr Gln Gln Ile Arg 290 295 300 Gln Arg Val Leu Arg Val Phe Ser Leu Lys Gly 305 310 315

<210> 1241 <211> 960 <212> DNA <213> Canis familiaris <400> 1241 atgatcacca tgattctttc caataattct cacttcccac atactttctt cttggctggt atcccaggac tgactgctgc ccacatttgg atctcacttc ccttttgctt catgttcttc ctggcaatga ctgggaattg tgtcctgctt tttcttatcc ggacagagcg cagccttcac

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Page 1401

069269_0225_SL.TXT cagcccatgt actctgccca tgtctttccc gccatggcca acaccatttg atctcctttc acctactgtg ctctatgcct tcctatgggc gcaggcagca ctttctgtgg gccaatctct aaacagattc ttttctttct agatgctggc agatgttctt tggaccgctt ttgttgccaa caaccttggc agcatatggc ttgctgtggc agattgtgag catgtacagc tcatgcagcg acttgctctt gtgatcagct tgccatgctc cattttctgg catccatgca tgtggccatc gattggaggc ttgtcggctg agtagtaaag aatctttctt gactgtgatt tcatgtctgt ctttggccca tccccctgcc gtttaaaatg tcctttgtcg tttggtgcta ttctctgcta tgtaacccac ctggtggttc ccctactgtg ttggcctgtg ggtgtggggg aattttcctt gtcatcctct cctacagcct ctggacccca ctaaggccca acctggttct cagctatcag tggagtcagg tacattatgc tgcgaggtgt gctctcatac gcgccaccac atgtggcctt cacctgaggc tcttctatgg ctgctgctaa ttgtctatgg agcagattga ctccctctcc ctcccactcc agtgctggtg aactattctt ggggttgacc aattgcctat tgtggataat tattgcttac acgtgctaaa accaggcttt ggttattctt ggtcaagacc tcccacctga

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960 <210> 1242 <211> 319 <212> PRT <213> Canis familiaris

<400> 1242 Met Ile Thr Met Ile Leu Ser Asn Asn Ser His Phe Pro His Thr Phe 1 5 10 15

Phe Leu Ala Gly 20 Ile Pro Gly Leu Thr Ala Ala His Ile Trp Ile Ser 25 30 Leu Pro Phe Cys Phe Met Phe Phe Leu Ala Met Thr Gly Asn Cys Val 35 40 45 Leu Leu Phe Leu Ile Arg Thr Glu Arg Ser Leu His Gln Pro Met Phe 50 55 60 Phe Phe Leu Ala Met Leu Ser Phe Val Asp Leu Val Leu Ser Leu Ser

65 70 75 80

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Thr Leu Pro Lys Met 85 Leu Ala Ile Phe Trp Phe Gly Ala Thr Ala Ile 90 95 Ser Ser His Ser Cys Leu Ser Gln Met Phe Phe Ile His Ala Phe Ser 100 105 110 Ala Met Glu Ser Gly Val Leu Val Ala Met Ala Met Asp Arg Phe Val 115 120 125 Ala Ile Cys Asn Pro Leu His Tyr Ala Thr Ile Leu Thr Pro Phe Val 130 135 140 Val Ala Lys Ile Gly Gly Leu Val Val Leu Arg Gly Val Gly Leu Thr 145 150 155 160 Ile Ser Phe Pro Thr Leu Ala Cys Arg Leu Pro Tyr Cys Gly Ser His 165 170 175 Thr Ile Ala Tyr Thr Tyr Cys Glu His Met Ala Val Val Lys Leu Ala 180 185 190 Cys Gly Ala Thr Thr Val Asp Asn Leu Tyr Ala Phe Ala Val Ala Ile 195 200 205 Phe Leu Gly Val Gly Asp Val Ala Phe Ile Ala Tyr Ser Tyr Gly Gln 210 215 220 Ile Val Arg Thr Val Ile Asn Phe Pro Ser Pro Glu Ala Arg Ala Lys 225 230 235 240 Ala Gly Ser Thr Cys Thr Ala His Val Cys Val Ile Leu Phe Phe Tyr 245 250 255 Gly Pro Gly Phe Leu Ser Val Val Met Gln Arg Phe Gly Pro Pro Thr 260 265 270 Ala Ser Ala Ala Lys Val Ile Leu Ala Asn Leu Tyr Leu Leu Phe Pro 275 280 285

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Pro Ala Leu Asp Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg 290 295 300

Asp Gln Leu Phe Lys Met Leu Arg Pro Lys Gln Ile Asp Pro Thr 305 310 315 <210> 1243 <211> 888 <212> DNA <213> Canis familiaris <400> 1243 ggaatcccag gcattcatga gtggcagcaa tggctctctc tacccctgac tctgctctgc 60 atcttagctc ttggtgccag tctcctcatg gtgatcacca tccaacatga agccatgctg 120 catgtgctta tgtaccactt tctgggcata ctggcagttg tggacatggg cctggccacc 180 atgatcatgc caaaaatcct atctatcttc tggtttaatg ccaaggccat cagcctccct 240 gagtgctttg ctcagattta tgccatccac tgcttcttgt gcatggaatc ccgtaccttt 300 ctctgcctgg cagtggacag atatgcagcc aattgtcacc cacttcaata cccttccata 360 gtcactgaag cttttgtgat caaagccaca gaatttatgg tgctcaggaa tggcctgttt 420 actatcccag tgcctatact ggcttcccag tcatgttatt gctccaagaa taaaattgac 480 cactgcctgt gctctaattt gagagtcacc agtctggcca gtgatgacat cactgtgaac 540 aaattttacc aactggtctt agcatgaatc ctgattggga gtgataagcc tctggctttt 600 tcttcctacg tgttaatact tcgctctgtg ctgaggttga actcaccaga agcaatgtca 660 aaggctctcg gtatccatag ctcccacttc atcctcatcc tcttcttcta cacaggtatc 720 attgtgctgt cacacaccgc tgtcacacac cttgcagaga aaaagattcc cctaaaaccc 780 atgctcctta atgtgctgca caatgttatc ccccctgcac tcaatcccat ggtctatgca 840 ctcaggatgc aggagctcag attgggcttc cagacactgc ttgggctg 888 <210> 1244 <211> 188 <212> PRT <213> Canis familiaris

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069269_0225_SL.TXT <400> 1244

Gly Ile Pro Gly Ile His Glu Trp Gln Gln Trp Leu Ser Leu Pro Leu 1 5 10 15 Thr Leu Leu Cys Ile Leu Ala Leu Gly Ala Ser Leu Leu Met Val Ile 20 25 30 Thr Ile Gln His Glu Ala Met Leu His Val Leu Met Tyr His Phe Leu 35 40 45 Gly Ile Leu Ala Val Val Asp Met Gly Leu Ala Thr Met Ile Met Pro 50 55 60 Lys Ile Leu Ser Ile Phe Trp Phe Asn Ala Lys Ala Ile Ser Leu Pro 65 70 75 80 Glu Cys Phe Ala Gln Ile Tyr Ala Ile His Cys Phe Leu Cys Met Glu 85 90 95 Ser Arg Thr Phe Leu Cys Leu Ala Val Asp Arg Tyr Ala Ala Asn Cys 100 105 110 His Pro Leu Gln Tyr Pro Ser Ile Val Thr Glu Ala Phe Val Ile Lys 115 120 125 Ala Thr Glu Phe Met Val Leu Arg Asn Gly Leu Phe Thr Ile Pro Val 130 135 140 Pro Ile Leu Ala Ser Gln Ser Cys Tyr Cys Ser Lys Asn Lys Ile Asp 145 150 155 160 His Cys Leu Cys Ser Asn Leu Arg Val Thr Ser Leu Ala Ser Asp Asp 165 170 175 Ile Thr Val Asn Lys Phe Tyr Gln Leu Val Leu Ala 180 185

<210> 1245 <211> 930 <212> DNA

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069269_0225_SL.TXT <213> Canis familiaris <400> 1245 cagtttttag tacctgaatt catcctcctg gggctcccag gcattcatga gtggcagcac 60 tggctctctc tgcccctggc tctgctctac atcttagctc tttgtgccaa catcctcatc 120 ttaatcacca tccaacatga gccttccctg caccagccca tgtattggtt ccttggtgtc 180 ttggctatag tggacattgg cctggctacc actatcatac ccaagatcct ggccattctc 240 tggtttgatg ccaaggccat cagcctccct gagtgctttg ctcagatcta tgccatccac 300 tcttttatgg gcatggagtc aggcatcttc ctctgcatgg ctatcgatag atatgtagcc 360 atttcctacc cccttcggta cccctccata ctcactgagg cttttatgat caaagtcaca 420 ctgtccatgg tgctcaggaa tggcctgttg accctcccag tgcctgtatt ggctgcccag 480 agacactatt gctccaggaa cgaaattgac cactgtctat gctctaattt gggggtcact 540 agtctggcct gtgatgacat cactattaac agattttacc agttggcctt ggcatgggtt 600 atgtttgggg gtgacatggg tctggtcttt gcttcctatg ctttgattat tcgctcagtg 660 ctgaggctga actctgctaa agcaacatca aaggccctga gtacctgcag ctcccatctc 720 atcctcattc tctttttcta cacggctgtt attgtggtgt ctgtcaccca gctagcagga 780 agaaagttcc cccttatccc tgctctcttc aatgtgctgc acagtatcat gcccccagcc 840 tttaacccca tggtttatgc cctccggacc caggagctga gagtgggctt ccagagggtg 900 cttggtttgg atgacaatgt gtccaggaag 930 <210> 1246 <211> 310 <212> PRT <213> Canis familiaris <400> 1246

Gln Phe Leu Val Pro Glu Phe Ile Leu Leu Gly Leu Pro Gly Ile His 1 5 10 15 Glu Trp Gln His Trp Leu Ser Leu Pro Leu Ala Leu Leu Tyr Ile Leu 20 25 30 Ala Leu Cys Ala Asn Ile Leu Ile Leu Ile Thr Ile Gln His Glu Pro

35 40 45

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Ser Leu 50 His Gln Pro Met Tyr Trp 55 Phe Leu Gly Val Leu Ala Ile 60 Val Asp Ile Gly Leu Ala Thr Thr Ile Ile Pro Lys Ile Leu Ala Ile Leu 65 70 75 80 Trp Phe Asp Ala Lys Ala Ile Ser Leu Pro Glu Cys Phe Ala Gln Ile 85 90 95 Tyr Ala Ile His Ser Phe Met Gly Met Glu Ser Gly Ile Phe Leu Cys 100 105 110 Met Ala Ile Asp Arg Tyr Val Ala Ile Ser Tyr Pro Leu Arg Tyr Pro 115 120 125 Ser Ile Leu Thr Glu Ala Phe Met Ile Lys Val Thr Leu Ser Met Val 130 135 140 Leu Arg Asn Gly Leu Leu Thr Leu Pro Val Pro Val Leu Ala Ala Gln 145 150 155 160 Arg His Tyr Cys Ser Arg Asn Glu Ile Asp His Cys Leu Cys Ser Asn 165 170 175 Leu Gly Val Thr Ser Leu Ala Cys Asp Asp Ile Thr Ile Asn Arg Phe 180 185 190 Tyr Gln Leu Ala Leu Ala Trp Val Met Phe Gly Gly Asp Met Gly Leu 195 200 205 Val Phe Ala Ser Tyr Ala Leu Ile Ile Arg Ser Val Leu Arg Leu Asn 210 215 220 Ser Ala Lys Ala Thr Ser Lys Ala Leu Ser Thr Cys Ser Ser His Leu 225 230 235 240 Ile Leu Ile Leu Phe Phe Tyr Thr Ala Val Ile Val Val Ser Val Thr 245 250 255

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Gln Leu Ala Gly 260 Arg Lys Phe Pro Leu Ile Pro Ala Leu Phe Asn Val 265 270 Leu His Ser Ile Met Pro Pro Ala Phe Asn Pro Met Val Tyr Ala Leu 275 280 285 Arg Thr Gln Glu Leu Arg Val Gly Phe Gln Arg Val Leu Gly Leu Asp 290 295 300 Asp Asn Val Ser Arg Lys

305 310 <210> 1247 <211> 954 <212> DNA <213> Canis familiaris <400> 1247 gatatctccc agaatgcacc caacagctca agatttcaag tgtctaactt catcctgatg gggcttccat gcattcatga atggcagctc tggctttccc tgcccctggc tgtgagatgt cttagctctt ggtgccaaca ttcttattgt gatcactgtt caccataagt ataacctcta gagcccatgt atcaattcct tagtgtcttg gttatagtgg acattggctt gtcaaaaatc atcatgccca agattttggc catattctgg tttgatgtca aggccattag cttccctgag tgctttactc aaatttatgc tgttcattgt tttattagca tagagtcagg catcttcttc tgcatggctg tggatagata tgtagccatc tgccacccca cttcaatact cctccatagt tactgaagct tttgtggtaa aagcacagtg ttcatggtgc ttaggaatgt actgttgacc atcccagtgc ctatagtgcc cagagacact attgctcccg gaatgaaatt gagcactgca tgtgctccaa cccaggggtt actggcttgg cccatgatga tattaccatt aaaatgttct atcaattggc tttggcatgg gtcctgggta gaagtagcaa ggttctagtc tttatttcct atgctctaat ctttcaatct gtgctggttc tgcactctac tgaggcaaat aatcaaggct ctgagcacct gccgttccca tctcatcttc atcttctttt tctacacagc cattgtgatg gtatctatag ctcatctggc tggaaaagca gttcccatct tccctgttct tctaaatgtg

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069269_0225_SL.TXT ctcaacattg tcatttcccc agccctcaac cccatggtat atgctcttag ggctcagggg 900 ttcagagtag gcttctggag ggtatttgag ttagaaaaga acgtgtcccc aaaa 954 <210> 1248 <211> 59 <212> PRT <213> Canis familiaris

<400> 1248 Leu Ala Gly Lys Ala Val Pro Ile Phe Pro Met 1 Val Ser Ile Ala His 5 10 15 Val Leu Leu Asn Val Leu Asn Ile Val Ile Ser Pro Ala Leu Asn Pro 20 25 30 Met Val Tyr Ala Leu Arg Ala Gln Gly Phe Arg Val Gly Phe Trp Arg 35 40 45 Val Phe Glu Leu Glu Lys Asn Val Ser Pro Lys 50 55

<210> 1249 <211> 861 <212> DNA <213> Canis familiaris <400> 1249

ttccatccca ctgtgttcat cctacttggc atcctgggac tgggaaacta ccatgccagg 60 ctttctatcc ccttctgcca catgtccatc actgcagtat tgggaaatga agccctcatc 120 cttgttgtct tcagtgaatg caccctccat gaacccatgt atgtcttcct atccatgttg 180 gctggcacta atatcctgct gtccaccacc actgttccca aggccctggc tatcttttgg 240 tttcatgctg gggagattgc ccttgatgcc tgcatcactc aggtgttttt catacatgtt 300 gcctttgtgg ctgagtcagg tatcctgatg gccatggcat ttgaccacta tgtggccatt 360 tgtactccct tgagatacat aaccatctta actcctatgg caattggaaa aatgactctg 420 gcaatcatgt tcctgatcat attcctgttg aagagactgc catactgtca aataaatatc 480 atcccccact tataatgtga gcatatctgg gtggccagat tggcctgtgc tgacatcact 540 gtcaatatct tgtatggctt ctcagtgcca atggcaccag ttttggtaga tattacactt 600

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tacactttga ttatccgagc tgtgtttaga cttccttccc aggattcctg gcacaaagct 660 ctcaatacct gtggttccca cattgaaatc attctctttt tcatcacatc cttttttact 720 ttcttgaccc attgatttgg caagaatatc ccccaccata tccacatcct tctggcaaat 780 ctctaagcat taatttcccc catgcttaat cccatcatct atggagcaaa aaccaagcaa 840

atcagggaca gtatggctca t 861 <210> 1250 <211> 164 <212> PRT <213> Canis familiaris <400> 1250 Phe His Pro Thr Val Phe Ile Leu Leu Gly Ile Leu Gly Leu Gly Asn 1 5 10 15 Tyr His Ala Arg Leu Ser Ile Pro Phe Cys His Met Ser Ile Thr Ala 20 25 30 Val Leu Gly Asn Glu Ala Leu Ile Leu Val Val Phe Ser Glu Cys Thr 35 40 45 Leu His Glu Pro Met Tyr Val Phe Leu Ser Met Leu Ala Gly Thr Asn 50 55 60 Ile Leu Leu Ser Thr Thr Thr Val Pro Lys Ala Leu Ala Ile Phe Trp 65 70 75 80 Phe His Ala Gly Glu Ile Ala Leu Asp Ala Cys Ile Thr Gln Val Phe 85 90 95 Phe Ile His Val Ala Phe Val Ala Glu Ser Gly Ile Leu Met Ala Met 100 105 110 Ala Phe Asp His Tyr Val Ala Ile Cys Thr Pro Leu Arg Tyr Ile Thr 115 120 125 Ile Leu Thr Pro Met Ala Ile Gly Lys Met Thr Leu Ala Ile Met Phe 130 135 140

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Leu Ile Ile Phe Leu Leu Lys Arg Leu Pro Tyr Cys Gln Ile Asn Ile 145 150 155 160

Ile Pro His Leu <210> 1251 <211> 969 <212> DNA <213> Canis familiaris <400> 1251

atgactcaca ccaactttac catcttccac cctgcagttt ttgtcttact gggcatccct 60 gggtgggagg cttaccacat ttggctatca gtacccctct gcctcatgta tatcactgct 120 gtcctgggga acaccatcct gatagtggtc atcatcacag atcgtaatct tcatgagccc 180 atgtacttct tcctctctat gctggccatc acggacatcc tgctgtctac cactactgta 240 cccaaagctc tagccatctt ttggctccat gcccataata ttgcttttga tgcttgtgtc 300 acccaagttt tctttgtcca tgtgatgttt gtaggggagt cagccatcct attagctatg 360 gcctttgacc gctttgtggc catctgtgct cccttgcatt atacaacagt gctaacatgg 420 cgagttgtgg gaaggattgc tctggccatt gtcacccgaa gcttttgcat catcttccca 480 gtgatcttct tattgaagcg gctgcccttc tgccggacca acatcgtccc ccattcctat 540 tgtgagcata ttggagtggc ccggttggcc tgtgctgaca tcaccattaa catctggtat 600 ggcttctcag tgcccattgt catggtcatc ttggatgtga tcctcattgc tgtgtcttac 660 tcactgatcc tccgagcagt gtttcgtttg ccctcccagg atgcccggca caaggccctc 720 agcacttgtg gctcccacct ctgtgtcatc ctcatgtttt atgttccatc cttctttaca 780 ctattgaccc accgctttgg acgtaacatt cctcgacatg tccatatcct gctggccaat 840 ctttatgtgg tggtaccacc catgctcaac cccatcgtct atggtgtgaa gactaagcag 900 atccgggagg gtgtagccca ccggtttctt gacatcaaga cttggtgctg tgcttcccct 960

ctgggctaa 969 <210> 1252

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069269_0225_SL.TXT <211> 322 <212> PRT <213> Canis familiaris

<400> 1252 Val 15 Leu Met 1 Thr His Thr Asn Phe Thr Ile 5 Phe His 10 Pro Ala Val Phe Leu Gly Ile Pro Gly Trp Glu Ala Tyr His Ile Trp Leu Ser Val Pro 20 25 30 Leu Cys Leu Met Tyr Ile Thr Ala Val Leu Gly Asn Thr Ile Leu Ile 35 40 45 Val Val Ile Ile Thr Asp Arg Asn Leu His Glu Pro Met Tyr Phe Phe 50 55 60 Leu Ser Met Leu Ala Ile Thr Asp Ile Leu Leu Ser Thr Thr Thr Val 65 70 75 80 Pro Lys Ala Leu Ala Ile Phe Trp Leu His Ala His Asn Ile Ala Phe 85 90 95 Asp Ala Cys Val Thr Gln Val Phe Phe Val His Val Met Phe Val Gly 100 105 110 Glu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Cys Ala Pro Leu His Tyr Thr Thr Val Leu Thr Trp Arg Val Val Gly 130 135 140 Arg Ile Ala Leu Ala Ile Val Thr Arg Ser Phe Cys Ile Ile Phe Pro 145 150 155 160 Val Ile Phe Leu Leu Lys Arg Leu Pro Phe Cys Arg Thr Asn Ile Val 165 170 175 Pro His Ser Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys Ala 180 185 190

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Asp Ile Thr 195 Ile Asn Ile Trp Tyr Gly Phe Ser Val Pro Ile Val Met 200 205 Val Ile Leu Asp Val Ile Leu Ile Ala Val Ser Tyr Ser Leu Ile Leu 210 215 220 Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg His Lys Ala Leu 225 230 235 240 Ser Thr Cys Gly Ser His Leu Cys Val Ile Leu Met Phe Tyr Val Pro 245 250 255 Ser Phe Phe Thr Leu Leu Thr His Arg Phe Gly Arg Asn Ile Pro Arg 260 265 270 His Val His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Gly 290 295 300 Val Ala His Arg Phe Leu Asp Ile Lys Thr Trp Cys Cys Ala Ser Pro 305 310 315 320

Leu Gly <210> 1253 <211> 963 <212> DNA <213> Canis familiaris <400> 1253 atggcagaag gtccacatcc caactccacc ttcccacgcc ccactttctt catactgact ggcattccag ggttaggggg tacccagacc tggctgacac tggtctttgg gcccatgtat ctgctggccc tgctgggaaa tggaacactg ttggcattgg tgcagataga ctccacactg cagcagccca tgtttctact cctggccaca ctggcagcca cagacctggg cttagccaca tctatagccc cagggttgct tgctgtgatg tggcttgggc cccggcctgt gccatatggt Page 1413

120

180

240

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069269_0225_SL.TXT

gtctgcctgg cccagatgtt ctttgttcat gcactgactg ctgtggaatc cggtgtactg 360 ttggccatgg cctgtgatcg tgctgtggca gtagggcgtc ccctacatta ccctctccta 420 atcaccaaag cccgtgtagg ctatgcagca ctggcactgg ccctgaaagc tgtggctatt 480 gttgtgcctt tccctctgct ggtggcgcga tttgagtact tccgagccaa gaccatagac 540 catgcctact gtgcacacat ggcagtggta gagctggtgg tgggcaacac acaagctaac 600 aatttgtatg ggctggcact ttcactggct gtgtcaggca tagatatcct gggcatcgct 660 ggctcttatg gactcattgc ccacactgta ctgcggctgc ctacctggga ggcccgggcc 720 aaggcctttg gcacatgtag ttcccacatc tgtgtcattc tggccttcta tgtacctggt 780 ctcttctcat acctcacaca tcgctttggt cgtcacacca tcccaaagcc tgtgcacatt 840 cttctctcta acatctattt gctgctgcca cctgccctca acccactcat ctatggagtc 900 cgcaccaagc aaatcaggga ccggctcctg gaaaccttca cattcagaaa aagccagctc 960 taa 963 <210> 1254 <211> 320 <212> PRT <213> Canis familiaris <400> 1254 Met Ala Glu i Gly Pro His Pro Asn Ser Thr Phe Pro Arg Pro Thr Phe 1 5 10 15 Phe Ile Leu Thr Gly Ile Pro Gly Leu Gly Gly Thr Gln Thr Trp Leu 20 25 30 Thr Leu Val Phe Gly Pro Met Tyr Leu Leu Ala Leu Leu Gly Asn Gly 35 40 45 Thr Leu Leu Ala Leu Val Gln Ile Asp Ser Thr Leu Gln Gln Pro Met 50 55 60 Phe Leu Leu Leu Ala Thr Leu Ala Ala Thr Asp Leu Gly Leu Ala Thr 65 70 75 80

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Ser Ile Ala Pro Gly 85 Leu Leu Ala Val Met Trp Leu Gly Pro Arg Pro 90 95 Val Pro Tyr Gly Val Cys Leu Ala Gln Met Phe Phe Val His Ala Leu 100 105 110 Thr Ala Val Glu Ser Gly Val Leu Leu Ala Met Ala Cys Asp Arg Ala 115 120 125 Val Ala Val Gly Arg Pro Leu His Tyr Pro Leu Leu Ile Thr Lys Ala 130 135 140 Arg Val Gly Tyr Ala Ala Leu Ala Leu Ala Leu Lys Ala Val Ala Ile 145 150 155 160 Val Val Pro Phe Pro Leu Leu Val Ala Arg Phe Glu Tyr Phe Arg Ala 165 170 175 Lys Thr Ile Asp His Ala Tyr Cys Ala His Met Ala Val Val Glu Leu 180 185 190 Val Val Gly Asn Thr Gln Ala Asn Asn Leu Tyr Gly Leu Ala Leu Ser 195 200 205 Leu Ala Val Ser Gly Ile Asp Ile Leu Gly Ile Ala Gly Ser Tyr Gly 210 215 220 Leu Ile Ala His Thr Val Leu Arg Leu Pro Thr Trp Glu Ala Arg Ala 225 230 235 240 Lys Ala Phe Gly Thr Cys Ser Ser His Ile Cys Val Ile Leu Ala Phe 245 250 255 Tyr Val Pro Gly Leu Phe Ser Tyr Leu Thr His Arg Phe Gly Arg His 260 265 270 Thr Ile Pro Lys Pro Val His Ile Leu Leu Ser Asn Ile Tyr Leu Leu 275 280 285

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Leu Pro Pro Ala Leu Asn Pro Leu Ile Tyr Gly Val Arg Thr Lys Gln 290 295 300

Ile Arg Asp Arg Leu Leu Glu Thr Phe Thr Phe Arg Lys Ser Gln Leu 305 310 315 320 <210> 1255 <211> 945 <212> DNA <213> Canis familiaris <400> 1255

atgccatttt tcaatcaaag cattttccac cctgcagtct tccttcttac tggcatccct 60 ggttttgaaa gttaccatgc ctggctctcc atccctttct gttgtctcta tgccattgcc 120 atctctggga atggtatgat cttgtttgtc atcctcactg agtcaagcct tcatgaaccc 180 atgtactatt tcctctccat gctctccttc acggacctag ggctgtgcct ttccacattg 240 gtcaccatgc tgcgtatttt ctggttcaat gctcaagaaa tcagttttga tgcctgcatt 300 agccaaatgt tctttatcca tggtttcaca ttcatggagt cctctgtact tctggtgatg 360 gcctttgacc gcttcattgc catctgtaac ccactgagat atgccacaat cttaaccaat 420 tcaaggatca tcaaagtggg ctttgccatt gttattagag ggacaacggc tctagtacct 480 ttactcctgc tcttaaagcg tctatccttc tgccgtagcc atgttctgca ccattcatat 540 tgtttccacc ctgatgtgat gaagctttca tgcacagata ccaagatcaa cagtgcattt 600 ggtttggcta ttgttatctc tactgctggc atagactctg tcttgatcct cctctcctat 660 gttctgatca tccactctgt gctcagcatt gcctccccaa aggagcggaa aaaggccttt 720 ggtacttgtg tctcacacat aagtgccgtt gccatcttct acatccccat gatcagcttg 780 tcactggtac acagatttgg gaagcatgcc cctccccttg tgcacaccct tattgccaat 840 gtttacctgc tcatccctcc tgtgatgaat cccataatct atagtgtgaa gaccaagcaa 900 attcgtaagg ctgtgctcaa aattttcctt tctaagctga tttag 945

<210> 1256 <211> 314 <212> PRT <213> Canis familiaris

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<400> 1256 Asn Gln Ser Ile Phe His Pro Ala Val Phe Leu 15 Leu Met 1 Pro Phe Phe 5 10 Thr Gly Ile Pro Gly Phe Glu Ser Tyr His Ala Trp Leu Ser Ile Pro 20 25 30 Phe Cys Cys Leu Tyr Ala Ile Ala Ile Ser Gly Asn Gly Met Ile Leu 35 40 45 Phe Val Ile Leu Thr Glu Ser Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ser Phe Thr Asp Leu Gly Leu Cys Leu Ser Thr Leu 65 70 75 80 Val Thr Met Leu Arg Ile Phe Trp Phe Asn Ala Gln Glu Ile Ser Phe 85 90 95 Asp Ala Cys Ile Ser Gln Met Phe Phe Ile His Gly Phe Thr Phe Met 100 105 110 Glu Ser Ser Val Leu Leu Val Met Ala Phe Asp Arg Phe Ile Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Ser Arg Ile Ile 130 135 140 Lys Val Gly Phe Ala Ile Val Ile Arg Gly Thr Thr Ala Leu Val Pro 145 150 155 160 Leu Leu Leu Leu Leu Lys Arg Leu Ser Phe Cys Arg Ser His Val Leu 165 170 175 His His Ser Tyr Cys Phe His Pro Asp Val Met Lys Leu Ser Cys Thr 180 185 190 Asp Thr Lys Ile Asn Ser Ala Phe Gly Leu Ala Ile Val Ile Ser Thr 195 200 205

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Ala Gly Ile Asp Ser Val Leu Ile Leu Leu Ser Tyr Val Leu Ile Ile 210 215 220 His Ser Val Leu Ser Ile Ala Ser Pro Lys Glu Arg Lys Lys Ala Phe 225 230 235 240 Gly Thr Cys Val Ser His Ile Ser Ala Val Ala Ile Phe Tyr Ile Pro 245 250 255 Met Ile Ser Leu Ser Leu Val His Arg Phe Gly Lys His Ala Pro Pro 260 265 270 Leu Val His Thr Leu Ile Ala Asn Val Tyr Leu Leu Ile Pro Pro Val 275 280 285 Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Arg Lys Ala 290 295 300 Val Leu Lys Ile Phe Leu Ser Lys Leu Ile

305 310

<210> 1257 <211> 903 <212> DNA <213> Canis familiaris <400> 1257 tcctcttcca tcattttcct gctaactggt gttcccagcc tggaagcctt ccacatctgg 60 atctccattc cctcctgctt tctctacata accaccctct cgagaaacag tctgatcctc 120 tttgccattg tcactcagcc cagcctccat gaacccatgt atgatttcct ctccatgctg 180 tctacccttg gcctatccat atccaccctg gtcactatgt tgggtatatt gtggtttgat 240 gccagggaga tcagctttaa tgcctgcttg tcacagatat ttttcattca acacttcact 300 gtcatggaat cctcagtgct gttgatcatg gcctttgatc attttgtggc catctctagt 360 cctcttaaat atccttctat cttaactgac cttaaaatag cacaggttgg agtagcagtc 420 atcaccaggg ggacactaat actgactcct atggtgttgc ttctcaaatg attgtccttc 480 tgccacagcc acgtactcca ccactcctac tgcttccacc ctgatatgat gaagctctca 540

Page 1418

069269_0225_SL.TXT tgcacagatg ccaggatcaa tagcgtagtt gggttgacag ccctgaagtt cacaccattg ctggagtgaa ctccatcttc tttatttttt cttatgtttt aatctttaag gatgtcctca gcattgcatc tccagaagag aggaagaaag ccttcagcat atgcatctca catattgagg ttgttgctgt attctgtatt ccattgatta gactgccctt tgttcacagg tttgggaaat gggccccacc ttatgtatgt actcttattg cctgcactta cctgctaatc cccctgtgtt gaactccatc ctctatagca tgaagaccaa cagatacgca gagctgtgtt caaagttctc cat

600

660

720

780

840

900

903 <210> 1258 <211> 156 <212> PRT <213> Canis familiaris

<400> 1258 Thr Gly Val Pro Ser Leu Glu Ala Ser 1 Ser Ser Ile Ile 5 Phe Leu Leu 10 15 Phe His Ile Trp Ile Ser Ile Pro Ser Cys Phe Leu Tyr Ile Thr Thr 20 25 30 Leu Ser Arg Asn Ser Leu Ile Leu Phe Ala Ile Val Thr Gln Pro Ser 35 40 45 Leu His Glu Pro Met Tyr Asp Phe Leu Ser Met Leu Ser Thr Leu Gly 50 55 60 Leu Ser Ile Ser Thr Leu Val Thr Met Leu Gly Ile Leu Trp Phe Asp 65 70 75 80 Ala Arg Glu Ile Ser Phe Asn Ala Cys Leu Ser Gln Ile Phe Phe Ile 85 90 95 Gln His Phe Thr Val Met Glu Ser Ser Val Leu Leu Ile Met Ala Phe 100 105 110 Asp His Phe Val Ala Ile Ser Ser Pro Leu Lys Tyr Pro Ser Ile Leu 115 120 125

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Thr Asp Leu Lys Ile Ala Gln Val Gly Val Ala Val Ile Thr Arg Gly 130 135 140

Thr Leu Ile Leu Thr Pro Met Val Leu Leu Leu Lys

145 150 155 <210> 1259 <211> 945 <212> DNA <213> Canis familiaris <400> 1259

atgccaattt tctataattc tacttttcct actttcctct tgactggggt ccctggactt 60 gagtgggccc atgcctggat ctcaatcccc ttctgttgcc tctatttaac tgctctttct 120 gggaataccc tgatcctgtt tgtagtcctc actgagccaa gcctccatga gcccatgtac 180 tatttcctct ccatgttgtc caccactgac attggcttat gcatctctac actggtgaca 240 gtactaggaa tattctggct caatgcccgg gagatcagct ttaatgcttg cttatcacaa 300 atgttcttca ttcacctctt cacgttcatg gaatcttcag tgctcctggc tatggctttt 360 gaccgttttg tggccatttc caaccccttg agatatgcta ccattctaac tcatgcaagg 420 atcacacaga ttggtttggc agtcattatc agggggactg tcattctgac accactagtc 480 ttgcttctta agcgtctatc attctgccga agttatgtgc tccatcattc ctactgcttc 540 catcctgatg taatgaagct ctcgtgttca gacacaaaga tcaacagtgc attcggacta 600 acagcgatta tctctactgc tggagtggac tctatcttta tcctactttc ctatgtcctg 660 atcattcgct cagttctcaa cattgcatcc ccggaggaaa ggaaaaaggc ctttagcacc 720 tgcatttctc atatcctggc cgtggccata ttctacatcc ctttaatcag cctgtctttt 780 gttcatagat ttggaaaaca ttctccacca tatgtgccca cactgattgc taatatttac 840 ttgctcattc cccctgtgat gaatcccatc atctatagtg tgaaaacaaa gcagattcaa 900 aaagctgtgc tcaaacttgt atgttccaag ggaactcgta tttaa 945

<210> 1260 <211> 314 <212> PRT

Page 1420

069269_0225_SL.TXT <213> Canis familiaris

<400> 1260 Phe Pro Thr Phe Leu Leu Thr Gly Met 1 Pro Ile Phe Tyr 5 Asn Ser Thr 10 15 Val Pro Gly Leu Glu Trp Ala His Ala Trp Ile Ser Ile Pro Phe Cys 20 25 30 Cys Leu Tyr Leu Thr Ala Leu Ser Gly Asn Thr Leu Ile Leu Phe Val 35 40 45 Val Leu Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Met Leu Ser Thr Thr Asp Ile Gly Leu Cys Ile Ser Thr Leu Val Thr 65 70 75 80 Val Leu Gly Ile Phe Trp Leu Asn Ala Arg Glu Ile Ser Phe Asn Ala 85 90 95 Cys Leu Ser Gln Met Phe Phe Ile His Leu Phe Thr Phe Met Glu Ser 100 105 110 Ser Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Ser Asn 115 120 125 Pro Leu Arg Tyr Ala Thr Ile Leu Thr His Ala Arg Ile Thr Gln Ile 130 135 140 Gly Leu Ala Val Ile Ile Arg Gly Thr Val Ile Leu Thr Pro Leu Val 145 150 155 160 Leu Leu Leu Lys Arg Leu Ser Phe Cys Arg Ser Tyr Val Leu His His 165 170 175 Ser Tyr Cys Phe His Pro Asp Val Met Lys Leu Ser Cys Ser Asp Thr 180 185 190 Lys Ile Asn Ser Ala Phe Gly Leu Thr Ala Ile Ile Ser Thr Ala Gly

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195 200 205 Val Asp Ser Ile Phe Ile Leu Leu Ser Tyr Val Leu Ile Ile Arg Ser 210 215 220 Val Leu Asn Ile Ala Ser Pro Glu Glu Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ile Ser His Ile Leu Ala Val Ala Ile Phe Tyr Ile Pro Leu Ile 245 250 255 Ser Leu Ser Phe Val His Arg Phe Gly Lys His Ser Pro Pro Tyr Val 260 265 270 Pro Thr Leu Ile Ala Asn Ile Tyr Leu Leu Ile Pro Pro Val Met Asn 275 280 285 Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Gln Lys Ala Val Leu 290 295 300 Lys Leu Val Cys Ser Lys Gly Thr Arg Ile

305 310 <210> 1261 <211> 978 <212> DNA <213> Canis familiaris <400> 1261

atgctacaaa tccaggaaaa catgcagatc ttaagcaacc tgacatctaa atttccaacc 60 ttcttgttgg ctggcattcc tggcctagaa tctgcccatg tgtggatctc tatccccttc 120 tgttgtctct ataccactgc cctctccggg aatagcatga tcctgtttgt catcattacc 180 cagaagagtc tccatgagcc catgtactat tttctctcca tgctttcagc tgctgactta 240 ggcttgactg tttctacaat gtcaacaaca ttaagtatcc tctggtttga tgcaattgaa 300 atcaatctgg atacctgcat tatccaaatg ttttttcttc atggatttac cttcatagaa 360 tctggggtgc tggtggctat ggcctttgac cgctatgtgg ccatctgtga tcctctgagg 420 tacactaccc ttctcactaa ttctagaatc attcagatgg gcctgttaat gactatacgc 480

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actttagtat tagtagtacc accacttttg ctccttaaac ccctctattt ctgtagaaca 540 aatgtccttt cccactccta ctgctaccac ccagatgtga ttaaattagc atgttcagat 600 acttgggcca atagcatctg tggattaatt gatctcatcc tgacaacagg aatagataca 660 ccatgcatta tcttgtctta tattttgatc attcattctg tcctcagtat tgcctcccct 720 gaagagagac ataaggtctt taacacttgt atctcccaca ttggagcagt ggctgttttc 780 tatatcccca tgatgagcct gtctttggtt catcgttatg gtccatcagc acccaaaata 840 gtccatttga tgatggccaa tatatatctg cttttgcctc ctgtgctcaa ccccatcatc 900 tatagtgtaa aaacaaaaca gattcgcaag gctatatact cagtcttctc cttacaaaat 960 aaacagatga ttgcctga 978 <210> 1262 <211> 325 <212> PRT <213> Canis familiaris <400> 1262 Met Leu Gln Ile Gln Glu Asn Met Gln Ile Leu Ser Asn Leu Thr Ser 1 5 10 15 Lys Phe Pro Thr Phe Leu Leu Ala Gly Ile Pro Gly Leu Glu Ser Ala 20 25 30 His Val Trp Ile Ser Ile Pro Phe Cys Cys Leu Tyr Thr Thr Ala Leu 35 40 45 Ser Gly Asn Ser Met Ile Leu Phe Val Ile Ile Thr Gln Lys Ser Leu 50 55 60 His Glu Pro Met Tyr Tyr Phe Leu Ser Met Leu Ser Ala Ala Asp Leu 65 70 75 80 Gly Leu Thr Val Ser Thr Met Ser Thr Thr Leu Ser Ile Leu Trp Phe 85 90 95 Asp Ala Ile Glu Ile Asn Leu Asp Thr Cys Ile Ile Gln Met Phe Phe

100 105 110

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Leu His Gly 115 Phe Thr Phe Ile Glu Ser Gly Val Leu Val Ala Met Ala 120 125 Phe Asp Arg Tyr Val Ala Ile Cys Asp Pro Leu Arg Tyr Thr Thr Leu 130 135 140 Leu Thr Asn Ser Arg Ile Ile Gln Met Gly Leu Leu Met Thr Ile Arg 145 150 155 160 Thr Leu Val Leu Val Val Pro Pro Leu Leu Leu Leu Lys Pro Leu Tyr 165 170 175 Phe Cys Arg Thr Asn Val Leu Ser His Ser Tyr Cys Tyr His Pro Asp 180 185 190 Val Ile Lys Leu Ala Cys Ser Asp Thr Trp Ala Asn Ser Ile Cys Gly 195 200 205 Leu Ile Asp Leu Ile Leu Thr Thr Gly Ile Asp Thr Pro Cys Ile Ile 210 215 220 Leu Ser Tyr Ile Leu Ile Ile His Ser Val Leu Ser Ile Ala Ser Pro 225 230 235 240 Glu Glu Arg His Lys Val Phe Asn Thr Cys Ile Ser His Ile Gly Ala 245 250 255 Val Ala Val Phe Tyr Ile Pro Met Met Ser Leu Ser Leu Val His Arg 260 265 270 Tyr Gly Pro Ser Ala Pro Lys Ile Val His Leu Met Met Ala Asn Ile 275 280 285 Tyr Leu Leu Leu Pro Pro Val Leu Asn Pro Ile Ile Tyr Ser Val Lys 290 295 300 Thr Lys Gln Ile Arg Lys Ala Ile Tyr Ser Val Phe Ser Leu Gln Asn 305 310 315 320

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Lys Gln Met Ile Ala 325 <210> 1263 <211> 870 <212> DNA <213> Canis familiaris <400> 1263 ctacttggaa tcccaggact ggagaattac caattttgga ttgcctctcc tctatgtgcc 60 atgtatttcg tagctatagt tggcaatatc attatccttc atataatctg aactgaccac 120 accctgcttg agcccatgta cctttttcta gccatgctgg ctatcactga cctggctcta 180 tcctcttcca cgcaacctaa aatgctggct atactctggt ttcgtgctca tgagattgaa 240 taccatgcct gcctcatcca ggtgttcttc atccatgcct tttcctctgt gaagtccagg 300 ttgttcatgg ctatggcctt ggacaattat gtggctatct gtttcccact ccaccactct 360 actttcctga ccccacccag ctgagtgggt aaactgggag tagctgtgat gatgagagga 420 ttgctatggg tgagcccctt ctgcattatg gtctccagga tgcccttctg ccccaaacac 480 atcattgtcc agtcatactg tgagcacatg gctgtgttaa agctggtgtg tgcagacact 540 agagtaaacc gtgcctatgg gctctttccg gctttctcgg tggttggctt tgatataatt 600 gtcatcagta catcccatgt gatgattctg agaactgttc tggggttgcc ctctgatgaa 660 gccaagttca aggcttttgg cacatgtgct tcccttatct gtatcatctt ggctttttat 720 atcccagccc tctttacttt cctcactcac cgctttggac accatgtgcc tcaagtggta 780 catatcatgt ttaccaattt ctatctcctg gtacctccca tgctcaaccc catcatctat 840 ggagtcagaa ccaagcagat cagggacagg 870 <210> 1264 <211> 154 <212> PRT <213> Canis familiaris <400> 1264

Met Met Arg Gly Leu Leu Trp Val Ser Pro Phe Cys Ile Met Val Ser 1 5 10 15

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Arg Met Pro Phe Cys Pro Lys His Ile Ile Val Gln Ser Tyr Cys Glu 20 25 30 His Met Ala Val Leu Lys Leu Val Cys Ala Asp Thr Arg Val Asn Arg 35 40 45 Ala Tyr Gly Leu Phe Pro Ala Phe Ser Val Val Gly Phe Asp Ile Ile 50 55 60 Val Ile Ser Thr Ser His Val Met Ile Leu Arg Thr Val Leu Gly Leu 65 70 75 80 Pro Ser Asp Glu Ala Lys Phe Lys Ala Phe Gly Thr Cys Ala Ser Leu 85 90 95 Ile Cys Ile Ile Leu Ala Phe Tyr Ile Pro Ala Leu Phe Thr Phe Leu 100 105 110 Thr His Arg Phe Gly His His Val Pro Gln Val Val His Ile Met Phe 115 120 125 Thr Asn Phe Tyr Leu Leu Val Pro Pro Met Leu Asn Pro Ile Ile Tyr 130 135 140 Gly Val Arg Thr Lys Gln Ile Arg Asp Arg

145 150 <210> 1265 <211> 945 <212> DNA <213> Canis familiaris <400> 1265 atactggctt cagggaacag ctcttcacat cctgtgttct tgatcctact tggaatccca ggactggaga attaccaatt ttggattgcc tttcctctat gtgccatgta ttttgttatt agctatagtt ggcaatatca ttatccttca tataatctga actgaccaca ccctgcttga gcccatgtac ctttttctag ccatgctggc tatcactgac ctggctctat cctcttccac gcaacctaaa atgctggcta tactctggtt tcgtgctcat gagattgaat accatgcctg

120

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240

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cctcatccag gtgttcttca tccatgcctt ttcctctgtg aagtccaggt tgttcatggc 360 tatggccttg gacaattatg tggctatctg tttcccactc caccactcta ctttcctgac 420 cccagctgag tgggtaaact gggagtagct gtgatgatga gaggattgct atgggtgagc 480 cccttctgca ttatggtctc caggatgccc ttctgcccca aacacatcat tgtccagtca 540 tactgtgagc acatggctgt gttaaagctg gtgtgtgcag acactagagt aaaccgtgcc 600 tatgggctct ttccggcttt ctcggtggtt ggctttgata taattgtcat cagtacatcc 660 catgtgatga ttctgagaac tgttctgggg ttgccctctg atgaagcccg gttcaaggct 720 tttggcacat gtgcttccct tatctgtatc atcttggctt tttatatccc agccctcttt 780 actttcctca ctcaccgctt tggacaccat gtgcctcaag tggtacatat catgtttacc 840 aatttctatc tcctggtacc tcccatgctc aaccccatca tctatggagt cagtaccaag 900 cagatcaggg acagggatat tcaaggttgt tgtggaaaag atccc 945

<210> 1266 <211> 164 <212> PRT <213> Canis familiaris

<400> 1266 Leu Leu 5 Trp Val Ser Pro Phe Cys Ile Met Val Ser Met Met 1 Arg Gly 10 15 Arg Met Pro Phe Cys Pro Lys His Ile Ile Val Gln Ser Tyr Cys Glu 20 25 30 His Met Ala Val Leu Lys Leu Val Cys Ala Asp Thr Arg Val Asn Arg 35 40 45 Ala Tyr Gly Leu Phe Pro Ala Phe Ser Val Val Gly Phe Asp Ile Ile 50 55 60 Val Ile Ser Thr Ser His Val Met Ile Leu Arg Thr Val Leu Gly Leu 65 70 75 80 Pro Ser Asp Glu Ala Arg Phe Lys Ala Phe Gly Thr Cys Ala Ser Leu 85 90 95

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Ile Cys Ile Ile Leu Ala Phe Tyr Ile 105 Pro Ala Leu Phe Thr 110 Phe Leu 100 Thr His Arg Phe Gly His His Val Pro Gln Val Val His Ile Met Phe 115 120 125 Thr Asn Phe Tyr Leu Leu Val Pro Pro Met Leu Asn Pro Ile Ile Tyr 130 135 140 Gly Val Ser Thr Lys Gln Ile Arg Asp Arg Asp Ile Gln Gly Cys Cys 145 150 155 160

Gly Lys Asp Pro <210> 1267 <211> 216 <212> DNA <213> Canis familiaris <400> 1267 atgttacaaa tccaggaaaa catgcagatc ttaagcaact tgacatctaa atttccaacc 60 ttcttgttgg ctggcattcc tggcctagaa tgtgtccatg tgtggatctc tatccccttc 120 tgctgtctct ataccattgc cctctctgga aatagcatga tcctatttgt catcattacc 180 cagaagagtt tccaagagcc catgcactat tttctt 216 <210> 1268 <211> 72 <212> PRT <213> Canis familiaris <400> 1268

Met Leu Gln Ile Gln Glu Asn Met Gln Ile Leu Ser Asn Leu Thr Ser 1 5 10 15 Lys Phe Pro Thr Phe Leu Leu Ala Gly Ile Pro Gly Leu Glu Cys Val 20 25 30 His Val Trp Ile Ser Ile Pro Phe Cys Cys Leu Tyr Thr Ile Ala Leu Page 142 8

069269_0225_SL.TXT 40 45

Ser Gly Asn Ser Met Ile Leu Phe Val Ile Ile Thr Gln Lys Ser Phe 50 55 60

Gln Glu Pro Met His Tyr Phe Leu

65 70 <210> 1269 <211> 987 <212> DNA <213> Canis familiaris <400> 1269

atgctggctt cagggaacag ctcttcacaa cctgtatcct ttatcctact tgggatccca 60 ggactggaga attaccaatt ttggattgcc tttccatttt gtgccatgta tctcatagct 120 atagtaggca atgtcattgt ccttcatata atccgaactg accacaccct gcatgagccc 180 atgtaccttt ttctagccat gctggctatc actgacctgg ctctatcctc ctccacacaa 240 cctaaaatgc tggctatact ctggtttcgt gctcatgaga ttgaatacca tgcctgcctc 300 atccaggtgt tcttcatcca tgccttttcc tccgtggagt ccgggttgct catggctatg 360 gccttggacc gttatgtggc tatctgcttc ccactccacc actctacttt cctgacccca 420 gctgtagtgg gtaaactggg agcagctgtg atgatgagag gtttgctatg ggtgagcccc 480 ttctgcatta tggtctccag gatgcccttc tgcaacaacc acgtcattcc ccagtcatac 540 tgtgagcaca tggctatgtt aaagctggtg tgtgcagaca ctagagtaaa ccgtgcatat 600 gggctctttg tggccttctc tgtggttggc tttgatataa ttgtcatcag tatatcctat 660 gtgatgattc tgagaactgt tctggggttg ccctctgatg aagcccggtt caaggctttt 720 ggcacatgtg cttcccatat ctgtgtcatc ttggcttttt atattccagc cctctttact 780 ttcctcaccc accgctttgg acatcatgtg ccccgagtgg tccatatcat gttcgccaat 840 ttctatctac tggtacctcc catgctcaac cccatcatct atggagtcag aaccaagcag 900 atcagggaca gggttattca aggttgttgt ggaaaagtcc ctaagccaag ggtcacagca 960 tcacaaccaa cctcgccacc ccactga 987

Page 1429

069269_0225_SL.TXT <210> 1270 <211> 328 <212> PRT <213> Canis familiaris

<400> 1270 Gly Asn Ser Ser Ser Gln Pro Val Ser Phe Ile Leu Met 1 Leu Ala Ser 5 10 15 Leu Gly Ile Pro Gly Leu Glu Asn Tyr Gln Phe Trp Ile Ala Phe Pro 20 25 30 Phe Cys Ala Met Tyr Leu Ile Ala Ile Val Gly Asn Val Ile Val Leu 35 40 45 His Ile Ile Arg Thr Asp His Thr Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Ala Ile Thr Asp Leu Ala Leu Ser Ser Ser Thr Gln 65 70 75 80 Pro Lys Met Leu Ala Ile Leu Trp Phe Arg Ala His Glu Ile Glu Tyr 85 90 95 His Ala Cys Leu Ile Gln Val Phe Phe Ile His Ala Phe Ser Ser Val 100 105 110 Glu Ser Gly Leu Leu Met Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Phe Pro Leu His His Ser Thr Phe Leu Thr Pro Ala Val Val Gly 130 135 140 Lys Leu Gly Ala Ala Val Met Met Arg Gly Leu Leu Trp Val Ser Pro 145 150 155 160 Phe Cys Ile Met Val Ser Arg Met Pro Phe Cys Asn Asn His Val Ile 165 170 175 Pro Gln Ser Tyr Cys Glu His Met Ala Met Leu Lys Leu Val Cys Ala 180 185 190

Page 1430

069269_0225_SL.TXT

Asp Thr Arg Val Asn Arg Ala Tyr Gly Leu Phe Val Ala Phe Ser Val 195 200 205 Val Gly Phe Asp Ile Ile Val Ile Ser Ile Ser Tyr Val Met Ile Leu 210 215 220 Arg Thr Val Leu Gly Leu Pro Ser Asp Glu Ala Arg Phe Lys Ala Phe 225 230 235 240 Gly Thr Cys Ala Ser His Ile Cys Val Ile Leu Ala Phe Tyr Ile Pro 245 250 255 Ala Leu Phe Thr Phe Leu Thr His Arg Phe Gly His His Val Pro Arg 260 265 270 Val Val His Ile Met Phe Ala Asn Phe Tyr Leu Leu Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Asp Arg 290 295 300 Val Ile Gln Gly Cys Cys Gly Lys Val Pro Lys Pro Arg Val Thr Ala 305 310 315 320 Ser Gln Pro Thr Ser Pro Pro His

325 <210> 1271 <211> 945 <212> DNA <213> Canis familiaris <400> 1271

atgctggcat cagggaacag ctcttcacat cctgtgttct tcatcctact tgggatccca 60 ggcctggaaa attaccagtt ttggattgcc tttcctctat gtgccatgta tctagtagct 120 atagttggaa atttcattac ccttcatata atccgaactg accacaccct gcatgagccc 180 atgtaccttt ttctagccat gctggctatc actgacctgg ctctatcctc ctccacacaa 240

Page 1431

069269_0225_SL.TXT cctaaaatgc tggctatact ctggtttcat gctcatgaga ttgaatacca tgcctgcctc atccaggtgt tcttcatcca tgccttttcc tccgtggagt ccgggttgct catggctatg gccttggacc gttatgtggc tatctgcttc ccactccacc actctactat cctgacccca actgtagtgg gtaaactggg agcagttgtg atgatgagag gtttgctatg ggtgagcccc ttctgcatta tggtctccag gatgcccttc tgcaacaacc acgtcattgc ccagtcatac tgtgagcaca tggctgtgtt aaagctggtg tgtgcagaca ctagagtaaa ccgtgcatat gggctctttg cggccttctc tgtggttggc tttgatataa ttgtcatcag tatatcctat gtgatgattc tgagaactgt tctggggttg ccctctgatg aagcccagtt caaggctttt ggcacatgtg cttcccatat ctgtgtcatc ttggcttttt atattccagc cctctttact ttcctcaccc accgctttgg acaccatgtg ccccgagtgg tccatatcat gttcgccaat ttctatctac ttgtacctcc catgctcaac cccatcatct atggagtcag aaccaagcag atcagggaca gggttattca aggttgttgt ggaaaagatc cctaa <210> 1272 <211> 314 <212> PRT <213> Canis familiaris <400> 1272

300

360

420

480

540

600

660

720

780

840

900

945

Met 1 Leu Ala Ser Gly Asn 5 Ser Ser Ser His Pro Val Phe Phe Ile Leu 10 15 Leu Gly Ile Pro Gly Leu Glu Asn Tyr Gln Phe Trp Ile Ala Phe Pro 20 25 30 Leu Cys Ala Met Tyr Leu Val Ala Ile Val Gly Asn Phe Ile Thr Leu 35 40 45 His Ile Ile Arg Thr Asp His Thr Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Ala Ile Thr Asp Leu Ala Leu Ser Ser Ser Thr Gln 65 70 75 80 Pro Lys Met Leu Ala Ile Leu Trp Phe His Ala His Glu Ile Glu Tyr Page 1432

069269_0225_SL.TXT

85 90 95

His Ala Cys Leu Ile Gln Val Phe Phe Ile His Ala Phe Ser Ser Val 100 105 110 Glu Ser Gly Leu Leu Met Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Phe Pro Leu His His Ser Thr Ile Leu Thr Pro Thr Val Val Gly 130 135 140 Lys Leu Gly Ala Val Val Met Met Arg Gly Leu Leu Trp Val Ser Pro 145 150 155 160 Phe Cys Ile Met Val Ser Arg Met Pro Phe Cys Asn Asn His Val Ile 165 170 175 Ala Gln Ser Tyr Cys Glu His Met Ala Val Leu Lys Leu Val Cys Ala 180 185 190 Asp Thr Arg Val Asn Arg Ala Tyr Gly Leu Phe Ala Ala Phe Ser Val 195 200 205 Val Gly Phe Asp Ile Ile Val Ile Ser Ile Ser Tyr Val Met Ile Leu 210 215 220 Arg Thr Val Leu Gly Leu Pro Ser Asp Glu Ala Gln Phe Lys Ala Phe 225 230 235 240 Gly Thr Cys Ala Ser His Ile Cys Val Ile Leu Ala Phe Tyr Ile Pro 245 250 255 Ala Leu Phe Thr Phe Leu Thr His Arg Phe Gly His His Val Pro Arg 260 265 270 Val Val His Ile Met Phe Ala Asn Phe Tyr Leu Leu Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Asp Arg

Page 1433

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290 295 300

Val Ile Gln Gly Cys Cys Gly Lys Asp Pro

305 310 <210> 1273 <211> 945 <212> DNA <213> Canis familiaris <400> 1273

atgttggtcc tcaataatac caatgctcaa cctctgacct tcttcctgac gggtatccca 60 ggcctgagag cagcccaggt ttggatctcc atcccttttt gtctcctgta tgtcatcgcc 120 ctctctggga acagcatgat cctatttgtg gtcttccgtg agcagaatct ccatgaacca 180 atgtattatt tcctctctat gctttcagcc acagacctga gcttatccct gtgcacactt 240 tctactactc ttggtgtctt ctggtttgaa gctcgagaaa tcaccttaag tgcctgcatt 300 gcccagatgt tctttctcca tggatttact ttcatggagt ctggggttct gctggccatg 360 gcctttgatc gttttgtagc catctgtaat ccactgagat acaccaccat cctcaccaat 420 gccagaatta cccagattgg ggtgagcatg ttgataagga acgttgctgt catgttacca 480 gtggtgctct ttgttaagag gctgtccttc tgcggtgcag tggtcctttc acattcttac 540 tgttaccatg ttgacctcat tcaactctca tgcacagaca acagaatcaa cagcatcctc 600 ggtctgtttg cacttttctc cacaacagga tttgattgtc cttgcatctt gctctcctat 660 gtactgatca tccggtctgt tctcagcatt gcctcctcag aggggcggca aaaagccttc 720 aacacctgca tatcccacat cagtgctgtt gccatctttt acatccccct tgtcagcttg 780 tctcttgtcc atcgctatgg ccattcagca cctccatttg tccacaccat catggccaat 840 gtcttccttc tcatccctcc cgtgctcaac cccatcatct atagtgtgaa gactaagcag 900 attcgaaagg ctattgtcaa ggtcttaatt cagaagcagc aataa 945

<210> 1274 <211> 314 <212> PRT <213> Canis familiaris <400> 1274

Page 1434

Met 1 Leu Val Leu Asn 5 Asn Thr 069269_0225_SL.TXT Asn Ala Gln Pro Leu Thr 10 Phe Phe 15 Leu Thr Gly Ile Pro Gly Leu Arg Ala Ala Gln Val Trp Ile Ser Ile Pro 20 25 30 Phe Cys Leu Leu Tyr Val Ile Ala Leu Ser Gly Asn Ser Met Ile Leu 35 40 45 Phe Val Val Phe Arg Glu Gln Asn Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ser Ala Thr Asp Leu Ser Leu Ser Leu Cys Thr Leu 65 70 75 80 Ser Thr Thr Leu Gly Val Phe Trp Phe Glu Ala Arg Glu Ile Thr Leu 85 90 95 Ser Ala Cys Ile Ala Gln Met Phe Phe Leu His Gly Phe Thr Phe Met 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Thr Thr Ile Leu Thr Asn Ala Arg Ile Thr 130 135 140 Gln Ile Gly Val Ser Met Leu Ile Arg Asn Val Ala Val Met Leu Pro 145 150 155 160 Val Val Leu Phe Val Lys Arg Leu Ser Phe Cys Gly Ala Val Val Leu 165 170 175 Ser His Ser Tyr Cys Tyr His Val Asp Leu Ile Gln Leu Ser Cys Thr 180 185 190 Asp Asn Arg Ile Asn Ser Ile Leu Gly Leu Phe Ala Leu Phe Ser Thr 195 200 205

Page 1435

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Thr Gly Phe Asp Cys Pro Cys Ile 215 Leu Leu Ser Tyr Val 220 Leu Ile Ile 210 Arg Ser Val Leu Ser Ile Ala Ser Ser Glu Gly Arg Gln Lys Ala Phe 225 230 235 240 Asn Thr Cys Ile Ser His Ile Ser Ala Val Ala Ile Phe Tyr Ile Pro 245 250 255 Leu Val Ser Leu Ser Leu Val His Arg Tyr Gly His Ser Ala Pro Pro 260 265 270 Phe Val His Thr Ile Met Ala Asn Val Phe Leu Leu Ile Pro Pro Val 275 280 285 Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Arg Lys Ala 290 295 300 Ile Val Lys Val Leu Ile Gln Lys Gln Gln 305 310

<210> 1275 <211> 951 <212> DNA <213> Canis familiaris <400> 1275 aatgtgtcct atagcagctt tctgctggtg ggcttcccag ggctgcagga gtcccgcgcc 60 ctcctggtgc tgcccttcct cagcctctat ctggtgatcg tctctgccaa tgcgctggtc 120 atccacacag tggtggccca gcggagcctg catcagccca tgtacctgct cattgccctg 180 ctcctcgctg tgaacatctg tgttgccacc actgtgcttc ccaccatgat gttcagcttc 240 tccacctact tcaaccacat ctccctgcct cgctgtctgt tccagatgtt ctgcatctac 300 ttcctcattg tctttgactg caatatcctc ctggtcatgg ccctagaccg ctatgttgcc 360 atctgctacc ctctccgcta tcccaagcta gtgacagccc agctgctggc tggcctgctg 420 ggcgcggcag ctgccaggag cacttgcatc gttgctcccg tggtggggtt ggcctcccag 480 gttcgcttct gccgttcaca cataatccac cactttgcct gtgagcacat ggccctcatg 540

Page 1436

069269_0225_SL.TXT

aagctctcct gtggggacat ctccctgaac aagactgtgg ggctcactgt ccgcatcttc 600 aacagagtcc tggacatgct actacttgga gcttcctact cccgcatcat ccatgccgcc 660 ttccggattt catcaggtag agcacgttcc aaggccctga acacctgtgg ctcccacctg 720 ctggtcatct tcaccatcta ctcttccacc atgtcctcat ccgtcgtcta ccgtgtggct 780 cgcgccgcct cataggacgt gcacaacctg ctcagtgcct tctacctgct gctcccgtgt 840 ctggtgaacc ccttcatcta tggagccagg accaaggaaa tccggcaaca cctggccact 900 ctgttccaaa gggcacagct accagcgccc cctgagaagc cccagtctct ^g 951

<210> 1276 <211> 264 <212> PRT <213> Canis familiaris

<400> 1276 Ser Phe Leu Leu Val Gly Phe Pro Gly Leu Gln Asn 1 Val Ser Tyr Ser 5 10 15 Glu Ser Arg Ala Leu Leu Val Leu Pro Phe Leu Ser Leu Tyr Leu Val 20 25 30 Ile Val Ser Ala Asn Ala Leu Val Ile His Thr Val Val Ala Gln Arg 35 40 45 Ser Leu His Gln Pro Met Tyr Leu Leu Ile Ala Leu Leu Leu Ala Val 50 55 60 Asn Ile Cys Val Ala Thr Thr Val Leu Pro Thr Met Met Phe Ser Phe 65 70 75 80 Ser Thr Tyr Phe Asn His Ile Ser Leu Pro Arg Cys Leu Phe Gln Met 85 90 95 Phe Cys Ile Tyr Phe Leu Ile Val Phe Asp Cys Asn Ile Leu Leu Val 100 105 110 Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Tyr Pro Leu Arg Tyr Pro 115 120 125

Page 1437

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Lys Leu 130 Val Thr Ala Gln Leu 135 Leu Ala Gly Leu Leu 140 Gly Ala Ala Ala Ala Arg Ser Thr Cys Ile Val Ala Pro Val Val Gly Leu Ala Ser Gln 145 150 155 160 Val Arg Phe Cys Arg Ser His Ile Ile His His Phe Ala Cys Glu His 165 170 175 Met Ala Leu Met Lys Leu Ser Cys Gly Asp Ile Ser Leu Asn Lys Thr 180 185 190 Val Gly Leu Thr Val Arg Ile Phe Asn Arg Val Leu Asp Met Leu Leu 195 200 205 Leu Gly Ala Ser Tyr Ser Arg Ile Ile His Ala Ala Phe Arg Ile Ser 210 215 220 Ser Gly Arg Ala Arg Ser Lys Ala Leu Asn Thr Cys Gly Ser His Leu 225 230 235 240 Leu Val Ile Phe Thr Ile Tyr Ser Ser Thr Met Ser Ser Ser Val Val 245 250 255 Tyr Arg Val Ala Arg Ala Ala Ser 260

<210> 1277 <211> 954 <212> DNA <213> Canis familiaris <400> 1277 atgctcactt ctcataatgt ctgttcagta cccagctcct tccagctcac tggcatccca gggctggagt ccctacatat ctggctttcc atcccctttg gctccatgta cctagttgct gtggtgggga atgtcaccat tctggctgtg gtaaaggtgg agcatagcct gcatcagccc atgtatttct tcctgtgtat gttggctgtc atcgacctgg ttctgtctac ttctactatg cccaaactgc tgggaatctt ctggtttggt gctggagaca ttggcctgga tgcctgccta

120

180

240

300

Page 1438

069269_0225_SL.TXT

gctcaaatgt tcctcatcca ctgctttgcc acagttgagt ccgggatctt ccttgccatg 360 gcttttgacc gctatgtagc catctgcaac ccactccatc acactacagt gctcactcat 420 actgtggtag gacgtttggg gctggctgcc ctcctccggg gtgtactcta catcggaccc 480 ctgcctttga tgatccgcct gcggctgccc ctttacaaat ctcgtgtcat ctcccactcc 540 tactgtgagc acatggctgt ggtcaccttg acctgtggtg acagcagggt caacaatgtc 600 tatgggctga gcattggctt tctggtcctg atcctggact caacagccat tgctgcctct 660 tatgtgatga ttttccgggc tgtgatgggg ctggccactc cggaggccag gcttaaaacc 720 ctgggaacat gtggttctca catctgtgcc attctgatct tttatgttcc tattgctgtt 780 tcttctctca ttcatcgatt tggtcaccag gtgcctcctc caatccacac tctactggcc 840 aacttctacc tcctcattcc tccaatcctc aatcccattg tctatgctgt ccgcaccaag 900 cagatccgag agcggcttct ccaaatcctc aagatagaaa ccaaaatcaa atga 954

<210> 1278 <211> 317 <212> PRT <213> Canis familiaris

<400> 1278 Asn Val Cys Ser Val Pro Ser Ser Phe Gln Leu Met 1 Leu Thr Ser His 5 10 15 Thr Gly Ile Pro Gly Leu Glu Ser Leu His Ile Trp Leu Ser Ile Pro 20 25 30 Phe Gly Ser Met Tyr Leu Val Ala Val Val Gly Asn Val Thr Ile Leu 35 40 45 Ala Val Val Lys Val Glu His Ser Leu His Gln Pro Met Tyr Phe Phe 50 55 60 Leu Cys Met Leu Ala Val Ile Asp Leu Val Leu Ser Thr Ser Thr Met 65 70 75 80 Pro Lys Leu Leu Gly Ile Phe Trp Phe Gly Ala Gly Asp Ile Gly Leu 85 90 95

Page 1439

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Asp Ala Cys Leu Ala Gln Met Phe Leu Ile His Cys Phe Ala Thr Val 100 105 110 Glu Ser Gly Ile Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu His His Thr Thr Val Leu Thr His Thr Val Val Gly 130 135 140 Arg Leu Gly Leu Ala Ala Leu Leu Arg Gly Val Leu Tyr Ile Gly Pro 145 150 155 160 Leu Pro Leu Met Ile Arg Leu Arg Leu Pro Leu Tyr Lys Ser Arg Val 165 170 175 Ile Ser His Ser Tyr Cys Glu His Met Ala Val Val Thr Leu Thr Cys 180 185 190 Gly Asp Ser Arg Val Asn Asn Val Tyr Gly Leu Ser Ile Gly Phe Leu 195 200 205 Val Leu Ile Leu Asp Ser Thr Ala Ile Ala Ala Ser Tyr Val Met Ile 210 215 220 Phe Arg Ala Val Met Gly Leu Ala Thr Pro Glu Ala Arg Leu Lys Thr 225 230 235 240 Leu Gly Thr Cys Gly Ser His Ile Cys Ala Ile Leu Ile Phe Tyr Val 245 250 255 Pro Ile Ala Val Ser Ser Leu Ile His Arg Phe Gly His Gln Val Pro 260 265 270 Pro Pro Ile His Thr Leu Leu Ala Asn Phe Tyr Leu Leu Ile Pro Pro 275 280 285 Ile Leu Asn Pro Ile Val Tyr Ala Val Arg Thr Lys Gln Ile Arg Glu 290 295 300

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Arg Leu Leu Gln Ile Leu Lys Ile Glu Thr Lys Ile Lys 305 310 315 <210> 1279 <211> 960 <212> DNA <213> Canis familiaris <400> 1279

atgagagacc tatttgtgat gtttgctctc aatacctcag aagttgaaat ctccaccttc 60 ctgttgattg gaatcccagg gcttgagcat gtgcacattt ggatctccat ccccatctgc 120 ttcatgtacc tcctggccat cctgggcaac tgcaccatcc tatttgttat caggacagag 180 ccttctctgc atgagcctat gtactatttc ctctctatgc tggccctatc tgacctgggc 240 ttgtctttct cttctcttcc ctccatgatg agaatcttct tgttcaatgc catggagatt 300 tctgctgatg catgtattgc ccaggaattt ttcatccatg gattcacaga catggaatcc 360 tcagtgcttc taatcatgtc ctttgatcgc tttctagcca ttcgcaaccc cctgaggtat 420 agctctattc ttaccagctc cagagttttg catattggac tgacatttgc tattaaaagc 480 attctactag ttcttcctct tcctttcact ttaaagagac tccaatactg taataaacgc 540 ctgctttcac actcctattg cctccaccag gatgtgatga aactggcctg ctctgacaat 600 agggttaact tttactatgg tctgtttgtt gcactctgca tgatgtcaga cagtgtgttc 660 attgcagttt cctatgtgtt catcctgaag actgtattgg gtattgcttc ccatggggag 720 cgactgaaag cccttaatac ctgtgtgtcc cacatctgtg ctgtgctcat cttctatgtg 780 cccatcatca ccttggctac catgcatcgc tttgccaagc ataaatcccc tctggctatg 840 attctgatag ctgatgcatt cttgttggta ccacctttga tgaaccctat tgtgtattgt 900 gtaaaaactc ggcagattag agtaaaagtc ctggaaaaac tgagtctaaa gtctaaatga 960

<210> 1280 <211> 319 <212> PRT <213> Canis familiaris <400> 1280

Met Arg Asp Leu Phe Val Met Phe Ala Leu Asn Thr Ser Glu Val Glu

Page 1441

0 6926 9_02 25_S L.TX T 1 5 10 15 Ile Ser Thr Phe Leu Leu Ile Gly Ile Pro Gly Leu Glu His Val His 20 25 30 Ile Trp Ile Ser Ile Pro Ile Cys Phe Met Tyr Leu Leu Ala Ile Leu 35 40 45 Gly Asn Cys Thr Ile Leu Phe Val Ile Arg Thr Glu Pro Ser Leu His 50 55 60 Glu Pro Met Tyr Tyr Phe Leu Ser Met Leu Ala Leu Ser Asp Leu Gly 65 70 75 80 Leu Ser Phe Ser Ser Leu Pro Ser Met Met Arg Ile Phe Leu Phe Asn 85 90 95 Ala Met Glu Ile Ser Ala Asp Ala Cys Ile Ala Gln Glu Phe Phe Ile 100 105 110 His Gly Phe Thr Asp Met Glu Ser Ser Val Leu Leu Ile Met Ser Phe 115 120 125 Asp Arg Phe Leu Ala Ile Arg Asn Pro Leu Arg Tyr Ser Ser Ile Leu 130 135 140 Thr Ser Ser Arg Val Leu His Ile Gly Leu Thr Phe Ala Ile Lys Ser 145 150 155 160 Ile Leu Leu Val Leu Pro Leu Pro Phe Thr Leu Lys Arg Leu Gln Tyr 165 170 175 Cys Asn Lys Arg Leu Leu Ser His Ser Tyr Cys Leu His Gln Asp Val 180 185 190 Met Lys Leu Ala Cys Ser Asp Asn Arg Val Asn Phe Tyr Tyr Gly Leu 195 200 205 Phe Val Ala Leu Cys Met Met Ser Asp Ser Val Phe Ile Ala Val Ser

Page 1442

069269_0225_SL.TXT

210 215 220

Tyr 225 Val Phe Ile Leu Lys Thr Val Leu Gly Ile Ala Ser His Gly Glu 230 235 240 Arg Leu Lys Ala Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu 245 250 255 Ile Phe Tyr Val Pro Ile Ile Thr Leu Ala Thr Met His Arg Phe Ala 260 265 270 Lys His Lys Ser Pro Leu Ala Met Ile Leu Ile Ala Asp Ala Phe Leu 275 280 285 Leu Val Pro Pro Leu Met Asn Pro Ile Val Tyr Cys Val Lys Thr Arg 290 295 300 Gln Ile Arg Val Lys Val Leu Glu Lys Leu Ser Leu Lys Ser Lys 305 310 315

<210> 1281 <211> 966 <212> DNA <213> Canis familiaris <400> 1281

atgtcaacat tcaaccaggc agtccacaat aacacttcaa tggcccccac cttcctgttg 60 gtgggcatgc caggtctgtc agctgtaccc tcctggtgga caataccact catcaccatc 120 taccttctct ctgccctggg caatggtact atcctctgga tcattgccct ggatcccacc 180 ctgcaccgcc caatgtactt cttcctcttc ctgctgagtg tgtctgatgt tggcttggcc 240 acagccctga tgcccaccct gctgggtctt gcccttgctg gcgtccatgc tgtccctgcc 300 tcagcttgcc tcctacagat gttctttgtc catgtctttt ctgtcatgga gtcctctgtt 360 ttgcttgcca tggccttaga tcgagcacta gccatctgcc gccctctcca ctacccaaca 420 cttctcacca atgatgtcat tagcaagatt ggcctggcta tagccttccg atgcttgggt 480 ctccacctgc ccctgccatt cctcctggct cacatgccct actgccaccc acaggttctg 540 acccattctt actgcttgca cccagatata gcccatttgg cctgtccagg agcttggggt 600

Page 1443

069269_0225_SL.TXT

gcattctata gcctctttgt ggttctgtca gccatgggat tagaccccct gcttattttc 660 ttctcctatg gcctaattgg cagggtgttg caaggtttgg gatccagtga ggatcgctgg 720 aaggctggtc aaacctgtgc tgcccatctc tctgctgtgc tcctctttta catgcccatg 780 atctttctgg ctctcattga ccgtctcagg gtgccaatac ctcagcctgc ccatactctt 840 ctctcctata tccacttcct gcttcctcca ttgataaacc ccattctcta tagtgtcaag 900 atgaaggaga ttagagagag aatactcaag aagttacagc ccaggaaggt gggttgtgtt 960

caatga 966 <210> 1282 <211> 321 <212> PRT <213> Canis familiaris

<400> 1282 Gln Ala Val His Asn Asn Thr Ser Met 10 Ala 15 Pro Met 1 Ser Thr Phe Asn 5 Thr Phe Leu Leu Val Gly Met Pro Gly Leu Ser Ala Val Pro Ser Trp 20 25 30 Trp Thr Ile Pro Leu Ile Thr Ile Tyr Leu Leu Ser Ala Leu Gly Asn 35 40 45 Gly Thr Ile Leu Trp Ile Ile Ala Leu Asp Pro Thr Leu His Arg Pro 50 55 60 Met Tyr Phe Phe Leu Phe Leu Leu Ser Val Ser Asp Val Gly Leu Ala 65 70 75 80 Thr Ala Leu Met Pro Thr Leu Leu Gly Leu Ala Leu Ala Gly Val His 85 90 95 Ala Val Pro Ala Ser Ala Cys Leu Leu Gln Met Phe Phe Val His Val 100 105 110 Phe Ser Val Met Glu Ser Ser Val Leu Leu Ala Met Ala Leu Asp Arg 115 120 125

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Ala Leu Ala Ile Cys Arg Pro Leu His Tyr Pro Thr Leu Leu Thr Asn 130 135 140 Asp Val Ile Ser Lys Ile Gly Leu Ala Ile Ala Phe Arg Cys Leu Gly 145 150 155 160 Leu His Leu Pro Leu Pro Phe Leu Leu Ala His Met Pro Tyr Cys His 165 170 175 Pro Gln Val Leu Thr His Ser Tyr Cys Leu His Pro Asp Ile Ala His 180 185 190 Leu Ala Cys Pro Gly Ala Trp Gly Ala Phe Tyr Ser Leu Phe Val Val 195 200 205 Leu Ser Ala Met Gly Leu Asp Pro Leu Leu Ile Phe Phe Ser Tyr Gly 210 215 220 Leu Ile Gly Arg Val Leu Gln Gly Leu Gly Ser Ser Glu Asp Arg Trp 225 230 235 240 Lys Ala Gly Gln Thr Cys Ala Ala His Leu Ser Ala Val Leu Leu Phe 245 250 255 Tyr Met Pro Met Ile Phe Leu Ala Leu Ile Asp Arg Leu Arg Val Pro 260 265 270 Ile Pro Gln Pro Ala His Thr Leu Leu Ser Tyr Ile His Phe Leu Leu 275 280 285 Pro Pro Leu Ile Asn Pro Ile Leu Tyr Ser Val Lys Met Lys Glu Ile 290 295 300 Arg Glu Arg Ile Leu Lys Lys Leu Gln Pro Arg Lys Val Gly Cys Val 305 310 315 320

Gln

Page 1445

069269_0225_SL.TXT <210> 1283 <211> 957 <212> DNA <213> Canis familiaris <400> 1283

atggcagata ataattattc tcacttccaa catccttact ttgtcttaac tggaattcca 60 gggcttgaac aaaagtatta ttggatggca ttcccactgg gtgctatata tatcatcgcc 120 ctttttggca atggtgtcat tatttctacc atcaagtctg aatcatccct gcatatccct 180 atgtactatt ttctgttcat gctggcattg gcagacatgg ggcttgccct ttgtactttg 240 ccctctatgc taggcatatt ttggtttaac tataagtcca ttgcttttga tgcctgcctt 300 gttcagatgt acttcattca taccttctct gccattgaat ctggcgtgct ggtggccatg 360 gcttttgatc gggttgtagc catctgggac cccctcaggt atggtaccat cttaaccaat 420 ggtgtggtcg gcagaacagg ggccatcatc ctgataagag cagtctttgt ggtcttccct 480 gtgcctttcc tcatcaagcg tcttcccttc taccgctcca acatcctctc ccactccttc 540 tgcctccacc aagacgtcat gcgacttgcc tgtgccagca ctcgtgtcaa cagtctctat 600 ggacttattg ctgtcatctt caccaagggt tctgactccc tctccatcct cttctcctat 660 gtgttcatat tccgaacagt aatggccatt gcctcaggga agggccggct gaaggcactc 720 aacacctgtg tttcacatat ctgtgctgta cttatcttct atgttccact cattggggta 780 tctgtcattc accgttttgg aaagcatctt tcaccactga ctcatgctct catggctaat 840 gcctaccttc ttgtaccccc tgtgcttaac cctatagtct atactgtgaa gaccaaggag 900 atacgaaaga aaatcatcca aatatttgtt caaaccaaga ttaccgcaga aggttag 957

<210> 1284 <211> 318 <212> PRT <213> Canis familiaris <400> 1284

Met Ala Asp Asn Asn Tyr Ser His Phe Gln His Pro Tyr Phe Val Leu

1 5 10 15

Thr Gly Ile Pro Gly Leu Glu Gln Lys Tyr Tyr Trp Met Ala Phe Pro

Page 1446

069269_0225_SL.TXT 25 30

Leu Gly Ala 35 Ile Tyr Ile Ile Ala Leu Phe Gly Asn Gly Val Ile Ile 40 45 Ser Thr Ile Lys Ser Glu Ser Ser Leu His Ile Pro Met Tyr Tyr Phe 50 55 60 Leu Phe Met Leu Ala Leu Ala Asp Met Gly Leu Ala Leu Cys Thr Leu 65 70 75 80 Pro Ser Met Leu Gly Ile Phe Trp Phe Asn Tyr Lys Ser Ile Ala Phe 85 90 95 Asp Ala Cys Leu Val Gln Met Tyr Phe Ile His Thr Phe Ser Ala Ile 100 105 110 Glu Ser Gly Val Leu Val Ala Met Ala Phe Asp Arg Val Val Ala Ile 115 120 125 Trp Asp Pro Leu Arg Tyr Gly Thr Ile Leu Thr Asn Gly Val Val Gly 130 135 140 Arg Thr Gly Ala Ile Ile Leu Ile Arg Ala Val Phe Val Val Phe Pro 145 150 155 160 Val Pro Phe Leu Ile Lys Arg Leu Pro Phe Tyr Arg Ser Asn Ile Leu 165 170 175 Ser His Ser Phe Cys Leu His Gln Asp Val Met Arg Leu Ala Cys Ala 180 185 190 Ser Thr Arg Val Asn Ser Leu Tyr Gly Leu Ile Ala Val Ile Phe Thr 195 200 205 Lys Gly Ser Asp Ser Leu Ser Ile Leu Phe Ser Tyr Val Phe Ile Phe 210 215 220 Arg Thr Val Met Ala Ile Ala Ser Gly Lys Gly Arg Leu Lys Ala Leu

Page 1447

0 6926 9_02 25_S L.TX T 225 230 235 240 Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Ile Phe Tyr Val Pro 245 250 255 Leu Ile Gly Val Ser Val Ile His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Leu Thr His Ala Leu Met Ala Asn Ala Tyr Leu Leu Val Pro Pro Val 275 280 285 Leu Asn Pro Ile Val Tyr Thr Val Lys Thr Lys Glu Ile Arg Lys Lys 290 295 300 Ile Ile Gln Ile Phe Val Gln Thr Lys Ile Thr Ala Glu Gly 305 310 315

<210> 1285 <211> 954 <212> DNA <213> Canis familiaris <400> 1285

atgacaatga actcaaacgc atcacatgtg aaccaccaca gtttcatttt gacgggtatc 60 cctgggatgc cagataaaaa tgcatggatg gcctttcccc tgggatttct ctacacacta 120 actctcctgg gaaatggtac catcttaact gtcatcaagg tagatgagag tctccatgag 180 cctatgtact acttcctctc catcttggct ctcactgatg ttagtctctc catgtccacc 240 ttgccctcca tgctcagcat cttctggttt aatgtccctg agattccttt tgatgcatgc 300 attacacaga tgtttttcat ccatggattt ggagtggtag aatcaggagt attagtgtcc 360 atggccttcg acagatttgt ggccatccga gatccattac gctatgcttc catcctcacc 420 catggcatca ttggaaagat tggaatagtt gtcctcaccc gggcagtctg tgtggtgttc 480 cctgtgccct tccttataaa gcggctacct ttttgccatt ccaatgtctt gtctcattct 540 tattgtctcc accaagatgc aatgaggcta gcctgtgcca gtacccgcat caacagtctc 600 tacggcctca tcatagtcat cttcacattg gggctggatg ctattatcat tctcttttct 660 tatgtgctca tcctgaagac tgtgctgggc attgcttcca gagatgaaag gctcaaagct 720

Page 1448

069269_0225_SL.TXT ctcaacacct gcctctctca catctgtgct gtgctcctct tctatattcc tctcattgga gtcaccatga tccacagatt tggaaagcat ttatcaccag tggtgcacac actcatggcc aatatctatc tgttactccc ccctgtgctc aatcccattg tctacagtgt gaagaccaag cagatacgaa ggcgaatcat acacatgttc cagaggagaa caaacagagc ctag

780

840

900

954 <210> 1286 <211> 317 <212> PRT <213> Canis familiaris <400> 1286

Met Thr 1 Met Asn Ser Asn Ala Ser His Val Asn His His Ser Phe 15 Ile 5 10 Leu Thr Gly Ile Pro Gly Met Pro Asp Lys Asn Ala Trp Met Ala Phe 20 25 30 Pro Leu Gly Phe Leu Tyr Thr Leu Thr Leu Leu Gly Asn Gly Thr Ile 35 40 45 Leu Thr Val Ile Lys Val Asp Glu Ser Leu His Glu Pro Met Tyr Tyr 50 55 60 Phe Leu Ser Ile Leu Ala Leu Thr Asp Val Ser Leu Ser Met Ser Thr 65 70 75 80 Leu Pro Ser Met Leu Ser Ile Phe Trp Phe Asn Val Pro Glu Ile Pro 85 90 95 Phe Asp Ala Cys Ile Thr Gln Met Phe Phe Ile His Gly Phe Gly Val 100 105 110 Val Glu Ser Gly Val Leu Val Ser Met Ala Phe Asp Arg Phe Val Ala 115 120 125 Ile Arg Asp Pro Leu Arg Tyr Ala Ser Ile Leu Thr His Gly Ile Ile 130 135 140

Page 1449

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Gly Lys Ile Gly Ile Val Val Leu Thr Arg Ala Val Cys Val Val Phe 145 150 155 160 Pro Val Pro Phe Leu Ile Lys Arg Leu Pro Phe Cys His Ser Asn Val 165 170 175 Leu Ser His Ser Tyr Cys Leu His Gln Asp Ala Met Arg Leu Ala Cys 180 185 190 Ala Ser Thr Arg Ile Asn Ser Leu Tyr Gly Leu Ile Ile Val Ile Phe 195 200 205 Thr Leu Gly Leu Asp Ala Ile Ile Ile Leu Phe Ser Tyr Val Leu Ile 210 215 220 Leu Lys Thr Val Leu Gly Ile Ala Ser Arg Asp Glu Arg Leu Lys Ala 225 230 235 240 Leu Asn Thr Cys Leu Ser His Ile Cys Ala Val Leu Leu Phe Tyr Ile 245 250 255 Pro Leu Ile Gly Val Thr Met Ile His Arg Phe Gly Lys His Leu Ser 260 265 270 Pro Val Val His Thr Leu Met Ala Asn Ile Tyr Leu Leu Leu Pro Pro 275 280 285 Val Leu Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile Arg Arg 290 295 300 Arg Ile Ile His Met Phe Gln Arg Arg Thr Asn Arg Ala 305 310 315 <210> 1287 <211> 951 <212> DNA <213> Canis familiaris <400> 1287 atgtcaccat tcaaccaaac tactgataac catcagaact tcatcttgac tgggattcca 60

Page 1450

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ggaatgccag agaaagactt ctggatggcc ttgcccctct gccttcttta cagtaccaca 120 ttcttaggta atgtcatcat ccttgttgtc atcaaggttg accgaagtct ccatgaacct 180 atgtattatt ttttggctat gctagctgcc actgacctca gcctttcatt atcttccatg 240 cccaccatga tcagtgttca ctggttcaac tggcgctcag taacctttga tgcctgcatc 300 actcagatgt tcttcatcca tacctttggg ggagtggaat caggtgttct ggtcgctatg 360 gcctttgatc gctttgtggc tattcgcttc cctttgcgct atgctaccat tctcactcat 420 ggaatcatcg gcaagattgg agcaaccgtc ctgctacgga gtgtgggtgc agtattccct 480 gtgcctttcc tcattaaaag gctacctttc tgccactcca atatcctttc ccatgcatac 540 tgcctccatc aggatgccat gaggcttgcc tgcgctgaca ctcgtgtcaa tagcatctat 600 ggcctcctgg ctgtgatctt catcattgta ctagatgcct tgatcctttt gatttcttac 660 tttctaattc tccaggcagt actgggcatt gcttcccgag aagagagact caaggctctc 720 aacacctgct tctcccatgt ctgtgcagta ctgctcttct acgtgcctct aattggcatg 780 actctgattc accgctttgg gaagcatttg tcaccaatag tacacatgct tctggccaat 840 gtctacctgc ttctccctcc tgtgctcaat cctgttgtgt acagtgttag gaccaagcag 900 atacggcagc gaattgtcag agtgttctgt gggggcagga ttggccctta a 951

<210> 1288 <211> 316 <212> PRT <213> Canis familiaris <400> 1288

Met Ser Pro Phe Asn Gln Thr Thr Asp Asn His Gln Asn Phe Ile Leu 1 5 10 15 Thr Gly Ile Pro Gly Met Pro Glu Lys Asp Phe Trp Met Ala Leu Pro 20 25 30 Leu Cys Leu Leu Tyr Ser Thr Thr Phe Leu Gly Asn Val Ile Ile Leu 35 40 45 Val Val Ile Lys Val Asp Arg Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60

Page 1451

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Leu 65 Ala Met Leu Ala Ala Thr Asp Leu Ser Leu Ser Leu Ser Ser Met 70 75 80 Pro Thr Met Ile Ser Val His Trp Phe Asn Trp Arg Ser Val Thr Phe 85 90 95 Asp Ala Cys Ile Thr Gln Met Phe Phe Ile His Thr Phe Gly Gly Val 100 105 110 Glu Ser Gly Val Leu Val Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Arg Phe Pro Leu Arg Tyr Ala Thr Ile Leu Thr His Gly Ile Ile Gly 130 135 140 Lys Ile Gly Ala Thr Val Leu Leu Arg Ser Val Gly Ala Val Phe Pro 145 150 155 160 Val Pro Phe Leu Ile Lys Arg Leu Pro Phe Cys His Ser Asn Ile Leu 165 170 175 Ser His Ala Tyr Cys Leu His Gln Asp Ala Met Arg Leu Ala Cys Ala 180 185 190 Asp Thr Arg Val Asn Ser Ile Tyr Gly Leu Leu Ala Val Ile Phe Ile 195 200 205 Ile Val Leu Asp Ala Leu Ile Leu Leu Ile Ser Tyr Phe Leu Ile Leu 210 215 220 Gln Ala Val Leu Gly Ile Ala Ser Arg Glu Glu Arg Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Phe Ser His Val Cys Ala Val Leu Leu Phe Tyr Val Pro 245 250 255 Leu Ile Gly Met Thr Leu Ile His Arg Phe Gly Lys His Leu Ser Pro 260 265 270

Page 1452

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Ile Val His Met Leu Leu Ala Asn Val Tyr Leu Leu Leu Pro Pro Val 275 280 285 Leu Asn Pro Val Val Tyr Ser Val Arg Thr Lys Gln Ile Arg Gln Arg 290 295 300 Ile Val Arg Val Phe Cys Gly Gly Arg Ile Gly Pro 305 310 315

<210> 1289 <211> 984 <212> DNA <213> Canis familiaris <400> 1289

atgataattt tcaataacac cacatcatct tccccaaact tcctactcac tgcatttcct 60 ggactggaac ttgctcatat ctggatctcc atccctgtct gctgtctcta caccattgcc 120 ctcttgggaa acagcatgat tctgtttgtc atcatcattg agagaagtct ccacaagccc 180 atgtactatt tcctctctat gctgtcagct gttgatctat gtctgaccat ctcaaccctt 240 cccactgtgc ttggggttct ctggtttcat gcccgggaga ttagcctgaa agcttgcctc 300 attcaaatgt tctttgtgca tggcttctcc ttcctggagt cctcagtgct ggtagccatg 360 gcctttgatc gctttatggc tatctgtaac ccaatgaagt atgccattat cttcacagac 420 atggtaatct tggtgattgg actggtcatc tgcctacggc aagttatttt cacctttccc 480 atggttctaa ccttgaagaa tgtatctttc tatgcaggca aagaactttc ccacccattt 540 tgctaccacc cagatatgat caaatactca tattccaacc cctggatcag cagttttttg 600 ggcatgtttc ttcagctcta cctgactggc actgacttac tcttcattct tttctcctac 660 attctgattc tccgaactgt cttgagcatt gtggccccta agaagcaaca aaaagctctc 720 agcacttgtg tctgtcatat ctgtgctgtc accattttct atgtgccaat gatcagcctg 780 tcccttacac atcgccttct cagctccacc ccaagagtgg tctgtagcat tttggccaat 840 gtttatttgc tcttaccgcc tgtactaaac cctatcattt acagcttgaa gaccaagacg 900 atccgccacg ctatgctcca gctgttccag tttaagggct cacggggccc caatgtgagg 960 ggtctcagag gacagtggga ttga 984

Page 1453

069269_0225_SL.TXT <210> 1290 <211> 327 <212> PRT <213> Canis familiaris

<400> 1290 Met 1 Ile Ile Phe Asn 5 Asn Thr Thr Ser Ser Ser Pro Asn Phe Leu Leu 10 15 Thr Ala Phe Pro Gly Leu Glu Leu Ala His Ile Trp Ile Ser Ile Pro 20 25 30 Val Cys Cys Leu Tyr Thr Ile Ala Leu Leu Gly Asn Ser Met Ile Leu 35 40 45 Phe Val Ile Ile Ile Glu Arg Ser Leu His Lys Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ser Ala Val Asp Leu Cys Leu Thr Ile Ser Thr Leu 65 70 75 80 Pro Thr Val Leu Gly Val Leu Trp Phe His Ala Arg Glu Ile Ser Leu 85 90 95 Lys Ala Cys Leu Ile Gln Met Phe Phe Val His Gly Phe Ser Phe Leu 100 105 110 Glu Ser Ser Val Leu Val Ala Met Ala Phe Asp Arg Phe Met Ala Ile 115 120 125 Cys Asn Pro Met Lys Tyr Ala Ile Ile Phe Thr Asp Met Val Ile Leu 130 135 140 Val Ile Gly Leu Val Ile Cys Leu Arg Gln Val Ile Phe Thr Phe Pro 145 150 155 160 Met Val Leu Thr Leu Lys Asn Val Ser Phe Tyr Ala Gly Lys Glu Leu 165 170 175

Page 1454

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Ser His Pro Phe Cys Tyr His Pro Asp Met Ile Lys Tyr Ser Tyr Ser 180 185 190 Asn Pro Trp Ile Ser Ser Phe Leu Gly Met Phe Leu Gln Leu Tyr Leu 195 200 205 Thr Gly Thr Asp Leu Leu Phe Ile Leu Phe Ser Tyr Ile Leu Ile Leu 210 215 220 Arg Thr Val Leu Ser Ile Val Ala Pro Lys Lys Gln Gln Lys Ala Leu 225 230 235 240 Ser Thr Cys Val Cys His Ile Cys Ala Val Thr Ile Phe Tyr Val Pro 245 250 255 Met Ile Ser Leu Ser Leu Thr His Arg Leu Leu Ser Ser Thr Pro Arg 260 265 270 Val Val Cys Ser Ile Leu Ala Asn Val Tyr Leu Leu Leu Pro Pro Val 275 280 285 Leu Asn Pro Ile Ile Tyr Ser Leu Lys Thr Lys Thr Ile Arg His Ala 290 295 300 Met Leu Gln Leu Phe Gln Phe Lys Gly Ser Arg Gly Pro Asn Val Arg 305 310 315 320 Gly Leu Arg Gly Gln Trp Asp

325 <210> 1291 <211> 936 <212> DNA <213> Canis familiaris <400> 1291 atgtacgctc tcaattcctc taaaattgag atcaccacct tcttcctgat tggaatccca ggactggagc atgttcatgt ttggatctct gtccctatct gcttcatgta cctagtggct atccttggca actgcaccat cctttttgtg atcaggacag agccgtcact tcatgccccc

120

180

Page 1455

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atgtactatt tcctctccat gttggctgtc tctgacctgg gcctctctct ctcatccttc 240 cccactatgc tgaggatctt tgttttcaat gctacgggga tttccccaaa tgcctgcttt 300 gctcaagaat tctttatcca tggattcaca gatatggagt cctcagtgct cctggtcatg 360 tcttttgacc gttttttggc catacgcaat cctctgagat acagctctat cctcaccaat 420 gccagagttg ccaaaatggg actggtgttt ctcattaaaa gtatgctctt agtgctccca 480 tttcctttca ccctcaaaaa attgacatat tgtaggaaaa gcctactttc tcactcttat 540 tgtctgcacc aggatgttat gaagctagcc tgctctgaca acaccatcaa ctttttctat 600 ggtttcttcg ttgccctctg tatgatgtca gacagtgtgt tcattgctgt gtcctacata 660 tttatcctga agactgtgat gggaattgga tcccataaag agcggctcaa ggccctcaac 720 acctgtgtct cccacatctg tgccgtgctc atcttctatg tgcctatcat tgctttggct 780 tccatgcacc gttttggcaa gcacaagtcc ccagtggcca tgatcctcat tgctgacatt 840 ttcttgctag taccacctct aatgaacccc attgtatact gtgtgaagac acggcaaatt 900 cgtgagaagg tttgggggaa attaggtcta aaataa 936

<210> 1292 <211> 311 <212> PRT <213> Canis familiaris <400> 1292

Met Tyr Ala Leu Asn Ser Ser Lys Ile Glu Ile Thr Thr Phe Phe Leu 1 5 10 15 Ile Gly Ile Pro Gly Leu Glu His Val His Val Trp Ile Ser Val Pro 20 25 30 Ile Cys Phe Met Tyr Leu Val Ala Ile Leu Gly Asn Cys Thr Ile Leu 35 40 45 Phe Val Ile Arg Thr Glu Pro Ser Leu His Ala Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ala Val Ser Asp Leu Gly Leu Ser Leu Ser Ser Phe 65 70 75 80

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Pro Thr Met Leu Arg Ile Phe Val Phe Asn Ala Thr Gly Ile Ser Pro 85 90 95 Asn Ala Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Thr Asp Met 100 105 110 Glu Ser Ser Val Leu Leu Val Met Ser Phe Asp Arg Phe Leu Ala Ile 115 120 125 Arg Asn Pro Leu Arg Tyr Ser Ser Ile Leu Thr Asn Ala Arg Val Ala 130 135 140 Lys Met Gly Leu Val Phe Leu Ile Lys Ser Met Leu Leu Val Leu Pro 145 150 155 160 Phe Pro Phe Thr Leu Lys Lys Leu Thr Tyr Cys Arg Lys Ser Leu Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ser 180 185 190 Asp Asn Thr Ile Asn Phe Phe Tyr Gly Phe Phe Val Ala Leu Cys Met 195 200 205 Met Ser Asp Ser Val Phe Ile Ala Val Ser Tyr Ile Phe Ile Leu Lys 210 215 220 Thr Val Met Gly Ile Gly Ser His Lys Glu Arg Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Val Ser His Ile Cys Ala Val Leu Ile Phe Tyr Val Pro Ile 245 250 255 Ile Ala Leu Ala Ser Met His Arg Phe Gly Lys His Lys Ser Pro Val 260 265 270 Ala Met Ile Leu Ile Ala Asp Ile Phe Leu Leu Val Pro Pro Leu Met 275 280 285

Page 1457

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Asn Pro Ile Val Tyr Cys Val Lys Thr Arg Gln Ile Arg Glu Lys Val 290 295 300

Trp Gly Lys Leu Gly Leu Lys

305 310 <210> 1293 <211> 939 <212> DNA <213> Canis familiaris <400> 1293

atgtctgctt ccaatagttc tgaggtccag ctttttcttc tgattggaat cccaggtctg 60 gaacatgctc acatctggat ctccattccc atttgcctcg tgtacctggt tgccatcatg 120 ggcaacagca ccattctttt tatcattagg acagaaccct cacttcatga gcccatgtac 180 tatttccttg ccctgttggc catctctgac ctgggcctat ccttctcctc ccttcctact 240 atgctgagaa tcttcttgtt caattccatg ggaatttcac ccaatgcttg ctttgctcaa 300 ccaatgcttg ctttgctcaa agaattcttc atccatggat tcactgtcat ggaatcctcc 360 atgcttctag ctatgtcttt ggatcgcttt cttgccattc ataatcccct gagatacagt 420 tctctcctca ctagtgacag agttgctaaa atgtgcctga tcttagccat caggagcatt 480 ctcttagtgc ttccattccc cttcactcta aggagattaa aatattgtca gaagaatctc 540 ctttctcact catactgtct gcatcaggat accatgaagc tagcctgctc tgacaacaaa 600 atcaatgtta tctatggctt ctttgttgct ctctgtacta tgctggactt ggcattaatt 660 tttctgtcat atatgctcat cttgaagact gtattcagca ttgcatctct ggcagagagg 720 ctcagggctc tcaatacctg tgtctcccac atctgtgctg tgctcatttt ctatgtaccc 780 atcatcaccc ttgctgccat gcaccgcttt gccaagcaca aaagccctct agttgtaatc 840 cttgttgcag atatattctt gttgttcccg cctctaatga accccattgt gtattgtgta 900 aaaactcaac aaatctggga aaaggtcttg ggaaagttg 939

<210> 1294 <211> 313 <212> PRT <213> Canis familiaris

Page 1458

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<400> 1294 Leu Phe Leu Leu Ile 15 Gly Met 1 Ser Ala Ser Asn Ser 5 Ser Glu Val Gln 10 Ile Pro Gly Leu Glu His Ala His Ile Trp Ile Ser Ile Pro Ile Cys 20 25 30 Leu Val Tyr Leu Val Ala Ile Met Gly Asn Ser Thr Ile Leu Phe Ile 35 40 45 Ile Arg Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ala 50 55 60 Leu Leu Ala Ile Ser Asp Leu Gly Leu Ser Phe Ser Ser Leu Pro Thr 65 70 75 80 Met Leu Arg Ile Phe Leu Phe Asn Ser Met Gly Ile Ser Pro Asn Ala 85 90 95 Cys Phe Ala Gln Pro Met Leu Ala Leu Leu Lys Glu Phe Phe Ile His 100 105 110 Gly Phe Thr Val Met Glu Ser Ser Met Leu Leu Ala Met Ser Leu Asp 115 120 125 Arg Phe Leu Ala Ile His Asn Pro Leu Arg Tyr Ser Ser Leu Leu Thr 130 135 140 Ser Asp Arg Val Ala Lys Met Cys Leu Ile Leu Ala Ile Arg Ser Ile 145 150 155 160 Leu Leu Val Leu Pro Phe Pro Phe Thr Leu Arg Arg Leu Lys Tyr Cys 165 170 175 Gln Lys Asn Leu Leu Ser His Ser Tyr Cys Leu His Gln Asp Thr Met 180 185 190 Lys Leu Ala Cys Ser Asp Asn Lys Ile Asn Val Ile Tyr Gly Phe Phe 195 200 205

Page 1459

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Val Ala Leu Cys Thr Met Leu Asp Leu Ala Leu Ile Phe Leu Ser Tyr 210 215 220 Met Leu Ile Leu Lys Thr Val Phe Ser Ile Ala Ser Leu Ala Glu Arg 225 230 235 240 Leu Arg Ala Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Ile 245 250 255 Phe Tyr Val Pro Ile Ile Thr Leu Ala Ala Met His Arg Phe Ala Lys 260 265 270 His Lys Ser Pro Leu Val Val Ile Leu Val Ala Asp Ile Phe Leu Leu 275 280 285 Phe Pro Pro Leu Met Asn Pro Ile Val Tyr Cys Val Lys Thr Gln Gln 290 295 300 Ile Trp Glu Lys Val Leu Gly Lys Leu

305 310 <210> 1295 <211> 942 <212> DNA <213> Canis familiaris <400> 1295

atgactttgg gatccctgga aagcagcagc aacatttcct ccacctttct gctgagtggc 60 attcctgggc tagagcacat gcacatctgg atctccatcc cactgtgctt tatatacctg 120 gtttccatcc tgggtaactg tacaatcctt tttatcatta aaacagagcc ctcactccat 180 gagcctatgt acctcttctt gtccatgctg gctgtgactg acctgggtct gtcactttgc 240 accctcccta cagtgctggg catcttttgg attggagcac gagatattgg tcatgatgct 300 tgttttgctc agctcttttt tattcactgc ttgtccttcc tggagtcctc tgtgctacta 360 tccatggcct ttgaccgctt tgtggccatt tgtcgcccct tgcactatgc ttccattctc 420 accaacactg tcattggcag gattggcctg gcttccctag gccgcagtgt agcactcatt 480

Page 1460

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tttccattgc cttttatgct caaaagattc ccctattgtg gctctccagt tctctcacat 540 tcttattgtc tccaccagga agtgatgaaa ttggcctgtg cagacatcaa agccaacagt 600 gtctatggga tgtttgtcat tgtttcaaca gtgggtatag actcactgct cattctcttc 660 tcttatgccc tgatcctgcg tactgtgctg tccattgcat ccagggctga gagattcaaa 720 gctcttaaca cctgtgtttc tcacatatgt gctgtgctcc tcttctacac tcccatgatt 780 ggcttgtctg tcatccaccg ctttgggaag cagggatctc atctggtcca ggtgatcatg 840 ggctttgtat accttctatt ccctcctctg atgaacccca tcgtctacag tgtgaagacc 900 aaacagatcc gagatcgtgt aacccatgct ttttgttgct aa 942

<210> 1296 <211> 313 <212> PRT <213> Canis familiaris <400> 1296

Met Thr Leu Gly Ser Leu Glu Ser Ser Ser Asn Ile Ser Ser Thr Phe 1 5 10 15 Leu Leu Ser Gly Ile Pro Gly Leu Glu His Met His Ile Trp Ile Ser 20 25 30 Ile Pro Leu Cys Phe Ile Tyr Leu Val Ser Ile Leu Gly Asn Cys Thr 35 40 45 Ile Leu Phe Ile Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr 50 55 60 Leu Phe Leu Ser Met Leu Ala Val Thr Asp Leu Gly Leu Ser Leu Cys 65 70 75 80 Thr Leu Pro Thr Val Leu Gly Ile Phe Trp Ile Gly Ala Arg Asp Ile 85 90 95 Gly His Asp Ala Cys Phe Ala Gln Leu Phe Phe Ile His Cys Leu Ser 100 105 110 Phe Leu Glu Ser Ser Val Leu Leu Ser Met Ala Phe Asp Arg Phe Val

Page 1461

115 069269_0225_SL.TXT 120 125 Ala Ile Cys Arg Pro Leu His Tyr Ala Ser Ile Leu Thr Asn Thr Val 130 135 140 Ile Gly Arg Ile Gly Leu Ala Ser Leu Gly Arg Ser Val Ala Leu Ile 145 150 155 160 Phe Pro Leu Pro Phe Met Leu Lys Arg Phe Pro Tyr Cys Gly Ser Pro 165 170 175 Val Leu Ser His Ser Tyr Cys Leu His Gln Glu Val Met Lys Leu Ala 180 185 190 Cys Ala Asp Ile Lys Ala Asn Ser Val Tyr Gly Met Phe Val Ile Val 195 200 205 Ser Thr Val Gly Ile Asp Ser Leu Leu Ile Leu Phe Ser Tyr Ala Leu 210 215 220 Ile Leu Arg Thr Val Leu Ser Ile Ala Ser Arg Ala Glu Arg Phe Lys 225 230 235 240 Ala Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Leu Phe Tyr 245 250 255 Thr Pro Met Ile Gly Leu Ser Val Ile His Arg Phe Gly Lys Gln Gly 260 265 270 Ser His Leu Val Gln Val Ile Met Gly Phe Val Tyr Leu Leu Phe Pro 275 280 285 Pro Leu Met Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile Arg 290 295 300 Asp Arg Val Thr His Ala Phe Cys Cys 305 310

<210> 1297

Page 1462

069269_0225_SL.TXT <211> 960 <212> DNA <213> Canis familiaris <400> 1297

atgacaatct cttataatag cagcctccaa aaagccactt tcttcctaac gggcttccaa 60 ggtctggaag atctccacgg ctggatctct attcccttct gcttcatcta cttgacagtt 120 attgtaggaa accttaccat cctccacgtc atccgtactg atgtcaccct ccatgaaccc 180 atgtactatt tcttggccat gctggctctg acagatttgg gcctttgtct atctacactg 240 cccactgtgt tgggcatctt ctggtttgat gccagagaga ttggcatccc tgcctgtttc 300 actcagctct tcttcatcca tactttgtct ctggtagagt cctcagttct attgtccatg 360 tctattgacc gctatgtggc catctgcaac ccattgcgtt actccacagt cttgaccccc 420 acacgtattg tcaggatggg gctgacttca atgcttagaa gtgccctgct catcctgcca 480 ttgccattcc tccttaaacg cttccagtac tgccgctccc atgtgctggc ccatgcttat 540 tgtctgcacc tagagatcat gaagctggcc tgctctagca tcattgtcaa tcgcatatat 600 gggctctttg tcgtggcctg cactgttggt gtggattcac tgctcatctt cctctcctat 660 gccctcatcc tccgcactgt gttaagcatt gcatcccgtc aggagcgact tcgggccctc 720 aacacctgcg tctcccacat ctgtgctgtg ctactcttct acattcctat gattggcttg 780 tctcttgtgc atcgctttgg tgaacatctg ccccgtattg tacacctcct catgtcttat 840 gtgtatctgc tggtaccacc tctcatgaac cccattgtct acagtatcaa gaccaagcaa 900 atccgcattc gcattgctaa gaagtgtgac tttgtaaaat ctcttaggtg ttttcgatag 960

<210> 1298 <211> 319 <212> PRT <213> Canis familiaris <400> 1298

Met Thr Ile Ser Tyr Asn Ser Ser Leu Gln Lys Ala Thr Phe Phe Leu 1 5 10 15

Thr Gly Phe Gln Gly Leu Glu Asp Leu His Gly Trp Ile Ser Ile Pro 20 25 30

Page 1463

Phe Cys Phe 35 Ile Tyr Leu Thr 069269_0225_SL.TXT Val Ile Val Gly Asn Leu 40 45 Thr Ile Leu His Val Ile Arg Thr Asp Val Thr Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Gly Leu Cys Leu Ser Thr Leu 65 70 75 80 Pro Thr Val Leu Gly Ile Phe Trp Phe Asp Ala Arg Glu Ile Gly Ile 85 90 95 Pro Ala Cys Phe Thr Gln Leu Phe Phe Ile His Thr Leu Ser Leu Val 100 105 110 Glu Ser Ser Val Leu Leu Ser Met Ser Ile Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ser Thr Val Leu Thr Pro Thr Arg Ile Val 130 135 140 Arg Met Gly Leu Thr Ser Met Leu Arg Ser Ala Leu Leu Ile Leu Pro 145 150 155 160 Leu Pro Phe Leu Leu Lys Arg Phe Gln Tyr Cys Arg Ser His Val Leu 165 170 175 Ala His Ala Tyr Cys Leu His Leu Glu Ile Met Lys Leu Ala Cys Ser 180 185 190 Ser Ile Ile Val Asn Arg Ile Tyr Gly Leu Phe Val Val Ala Cys Thr 195 200 205 Val Gly Val Asp Ser Leu Leu Ile Phe Leu Ser Tyr Ala Leu Ile Leu 210 215 220 Arg Thr Val Leu Ser Ile Ala Ser Arg Gln Glu Arg Leu Arg Ala Leu 225 230 235 240

Page 1464

Asn Thr Cys Val Ser 245 His Ile 069269_0225_SL.TXT Cys Ala Val Leu Leu Phe 250 Tyr Ile 255 Pro Met Ile Gly Leu Ser Leu Val His Arg Phe Gly Glu His Leu Pro Arg 260 265 270 Ile Val His Leu Leu Met Ser Tyr Val Tyr Leu Leu Val Pro Pro Leu 275 280 285 Met Asn Pro Ile Val Tyr Ser Ile Lys Thr Lys Gln Ile Arg Ile Arg 290 295 300 Ile Ala Lys Lys Cys Asp Phe Val Lys Ser Leu Arg Cys Phe Arg 305 310 315

<210> 1299 <211> 963 <212> DNA <213> Canis familiaris <400> 1299

atgactgcct taaaccacac tgctgttagc cacacagtct tccacttgct gggtatccct 60 gggctagaag accagcacat gtggatttcc attcccttct tcatttccta cgtcatcgcc 120 ctgcttggga acagcctgct catctgcatt atcctcacga agcgcagcct ccatgaaccc 180 atgtacctct tcctctgcat gctggctgga gcagacattg tcctctccac ctgcacagta 240 ccacaggcct tggccatctt ctggttccat gctggggaga tctccttgga tcgctgcatt 300 actcagctct tcttcatcca taccaccttc atctctgagt cagggatctt gctggtgatg 360 gcctttgacc gctacattgc catatgctac ccactgagat acaccactat tcttacaggt 420 gcactgattg ggaaaatcgg tgtgaccatc ttcctgagaa gttatggtac aattttcccc 480 ataatatttc ttttgaaaag attgaccttc tgccaaaata atattattcc acatacctac 540 tgtgaacaca ttggtttggc caaatatgct tgtaatgaca tttatgctaa catctggtac 600 ggattttcca tcctaatgtt aacagtagtt ttagatgttg tgctaatttt tgtttcctat 660 gtgatgattc tccgtgctgt cttctgcatc ccttctcgag atgctcgcca taaagctctc 720 aacacttgtg gctcccatgt ctgcattatc atcctctttt atgggcctgg aatcttcaca 780

Page 1465

069269_0225_SL.TXT atccttactc gtttgcatgc atccgggagc tga aacgttttgg ttgccccacc aggtggttca atgccacatt tatgctcaat tgtattgttt ccacctcata cccatcattt acaaggcaga cccacatctt atgggatcaa aatcactttg gttggctaat gaccaagcaa gtttaggaac

840

900

960

963 <210> 1300 <211> 320 <212> PRT <213> Canis <400> 1300 Met Thr Ala 1 familiaris

Leu Gly Ile

Phe Phe Ile 35

Cys Ile Ile 50

Leu Cys Met 65

Pro Gln Ala

Asp Arg Cys

Glu Ser Gly 115

Cys Tyr Pro 130

Lys Ile Gly

Leu Asn 5 His Thr Pro 20 Gly Leu Glu Ser Tyr Val Ile Leu Thr Lys Arg 55 Leu Ala Gly 70 Ala Leu Ala 85 Ile Phe Ile 100 Thr Gln Leu Ile Leu Leu Val Leu Arg Tyr Thr 135 Val Thr Ile Phe

Ala Val Ser 10 His Thr Val Asp Gln 25 His Met Trp Ile Ala 40 Leu Leu Gly Asn Ser 45 Ser Leu His Glu Pro 60 Met Asp Ile Val Leu 75 Ser Thr Trp Phe His 90 Ala Gly Glu Phe Phe 105 Ile His Thr Thr Met 120 Ala Phe Asp Arg Tyr 125 Thr Ile Leu Thr Gly 140 Ala Leu Arg Ser Page Tyr Gly 1466 Thr

Phe

Ser

Leu

Tyr

Cys

Ile

Phe

110

Ile

Leu

Ile

His Leu 15

Ile Pro

Leu Ile

Leu Phe

Thr Val 80

Ser Leu 95

Ile Ser

Ala Ile

Ile Gly

Phe Pro

0 6926 9_02 25_S L.TX T 145 150 155 160 Ile Ile Phe Leu Leu Lys Arg Leu Thr Phe Cys Gln Asn Asn Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Ile Gly Leu Ala Lys Tyr Ala Cys Asn 180 185 190 Asp Ile Tyr Ala Asn Ile Trp Tyr Gly Phe Ser Ile Leu Met Leu Thr 195 200 205 Val Val Leu Asp Val Val Leu Ile Phe Val Ser Tyr Val Met Ile Leu 210 215 220 Arg Ala Val Phe Cys Ile Pro Ser Arg Asp Ala Arg His Lys Ala Leu 225 230 235 240 Asn Thr Cys Gly Ser His Val Cys Ile Ile Ile Leu Phe Tyr Gly Pro 245 250 255 Gly Ile Phe Thr Ile Leu Thr Gln Arg Phe Gly Cys His Ile Pro Pro 260 265 270 His Thr His Ile Leu Leu Ala Asn Val Cys Met Leu Ala Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Gly Ile Lys Thr Lys Gln Ile Arg Glu Gln 290 295 300 Val Val His Val Leu Phe Thr Arg Gln Lys Ser Leu Trp Phe Arg Asn 305 310 315 320

<210> 1301 <211> 942 <212> DNA <213> Canis familiaris <400> 1301 atgtctatta ttaatacatc aaatgttgaa atcaccacct tcttcttggt tgggatgcca gggctggaat atgcacacat ttggatctct atccccatct gcagcatgta tctttttgct

120

Page 1467

069269_0225_SL.TXT attttgggaa actgcaccat tctttttgtc atcaagacag agccctcctt gcacgaaccc atgtactact tcctttccat gttggcaatg tctgacatgg gcttgtctct ctcttctcta cctactgtgg gaaggatctt cttattcaat gcccctgaaa tttctgccaa tgcctgcttt gcccaggaat tcttcatcca tggattcaca gcagtggaat cctcagtgct tctgatcatg tcatttgacc gcttcctagc catccacagc cctctgagat acagctccat tctgactcct gtcagagttg ccaaaatagg aatagtatta tcccttaaga gtgtccttct agtactgccc ttccccttca ctttgagaag tttgaaatat tgcagtaaga gccaattatc ccattcctac tgtcttcacc aggatgtcat gaagttggcc tgctctgaca accgaattga tgtcatctat ggcttttttg gagcactttg tcttatggta gactttatgc tcattgctat atcttacatc ctgatcctca agactgtgct gggaattgca tccctaaatg agcagctcaa agccctcaat acttgtgctt cacacatctg tgcagtgatc atcttctacc tgcccatcat caaccttgcc attgtccatc gctttgtcag acatgtctca cctctcttca atgttctcat ggcaaatgtt cttttacttg tgcctccaat gatgaatccc attgtgtact gtgtgaaaac caggcaaata agagtgagag ttttagcaaa attatgccag aagcagatgt aa <210> 1302 <211> 313 <212> PRT <213> Canis familiaris

180

240

300

360

420

480

540

600

660

720

780

840

900

942 <400> 1302

Met Ser Ile Ile Asn Thr Ser Asn Val Glu Ile Thr Thr Phe Phe Leu 1 5 10 15 Val Gly Met Pro Gly Leu Glu Tyr Ala His Ile Trp Ile Ser Ile Pro 20 25 30 Ile Cys Ser Met Tyr Leu Phe Ala Ile Leu Gly Asn Cys Thr Ile Leu 35 40 45 Phe Val Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60

Page 1468

069269_0225_SL.TXT

Leu 65 Ser Met Leu Ala Met Ser Asp Met Gly Leu Ser Leu Ser Ser Leu 70 75 80 Pro Thr Val Gly Arg Ile Phe Leu Phe Asn Ala Pro Glu Ile Ser Ala 85 90 95 Asn Ala Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Thr Ala Val 100 105 110 Glu Ser Ser Val Leu Leu Ile Met Ser Phe Asp Arg Phe Leu Ala Ile 115 120 125 His Ser Pro Leu Arg Tyr Ser Ser Ile Leu Thr Pro Val Arg Val Ala 130 135 140 Lys Ile Gly Ile Val Leu Ser Leu Lys Ser Val Leu Leu Val Leu Pro 145 150 155 160 Phe Pro Phe Thr Leu Arg Ser Leu Lys Tyr Cys Ser Lys Ser Gln Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ser 180 185 190 Asp Asn Arg Ile Asp Val Ile Tyr Gly Phe Phe Gly Ala Leu Cys Leu 195 200 205 Met Val Asp Phe Met Leu Ile Ala Ile Ser Tyr Ile Leu Ile Leu Lys 210 215 220 Thr Val Leu Gly Ile Ala Ser Leu Asn Glu Gln Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Ala Ser His Ile Cys Ala Val Ile Ile Phe Tyr Leu Pro Ile 245 250 255 Ile Asn Leu Ala Ile Val His Arg Phe Val Arg His Val Ser Pro Leu 260 265 270

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Phe Asn Val Leu Met Ala Asn Val Leu Leu Leu Val Pro Pro Met Met 275 280 285 Asn Pro Ile Val Tyr Cys Val Lys Thr Arg Gln Ile Arg Val Arg Val 290 295 300 Leu Ala Lys Leu Cys Gln Lys Gln Met

305 310 <210> 1303 <211> 936 <212> DNA <213> Canis familiaris <400> 1303

tcggtcttta acacctctga agtggaaatc tctaccttct tcctcattgg gatccctggg 60 atgaagcatg ctcacatttg ggtttccatc cccatttgcc tcatgtacct ccttgccatc 120 ctggggaact gcaccatcct ctttttcata aaaacagaga cctctctgca tgagcctatg 180 tattatttcc tctccatgct ggccttttct gacctgggac tgtccatctc ctcccttcca 240 accatgctga gaatcttctt gttcaatgtc actggaattt cccctgatgc ttgctttgcc 300 caagagttct tcattcatgg attctcagcc atggaggcat cagtactctt catcatgtcc 360 attgatcgct tgatagccat ctgcaaccct ctgagatata cttccatccc caccagtgcc 420 agagtcatta aaattggcct catatttgct gcattatgta ttatgtttgt tctccctttc 480 ccctttattc tgaagaggct gaaattctgt aagaaaagtc ttctatccca ctcctactgc 540 ctccaccagg atgtcatgaa gcaggcctgt tctgacaaca gggtcaatgt catctatgga 600 ctatttgtgg ctcttatatc tttattgtat ttggtatgca ttgctgtgtc ttacatgctc 660 atcttgaaaa ttgttctggg cattacctca cacaagggcc gcctcaaggt cctcaacact 720 tgcatttccc acatctgtgc tgtgttcatc ttctatgttc ctattgtcac cttggctgcc 780 cttcaccgct ttgccaaaca tgtttcctca gttgttaggg tcatcatagc tgatatcttc 840 cttttggttc ccccgttaat gaatcccatt gtgtactctg tgaagagtca gcagattaga 900 aatcggatcc ttacaaaact gtgtgagaaa caaggt 936

<210> 1304

Page 1470

069269_0225_SL.TXT <211> 312 <212> PRT <213> Canis familiaris

<400> 1304 Leu 15 Ile Ser 1 Val Phe Asn Thr Ser Glu Val 5 Glu Ile 10 Ser Thr Phe Phe Gly Ile Pro Gly Met Lys His Ala His Ile Trp Val Ser Ile Pro Ile 20 25 30 Cys Leu Met Tyr Leu Leu Ala Ile Leu Gly Asn Cys Thr Ile Leu Phe 35 40 45 Phe Ile Lys Thr Glu Thr Ser Leu His Glu Pro Met Tyr Tyr Phe Leu 50 55 60 Ser Met Leu Ala Phe Ser Asp Leu Gly Leu Ser Ile Ser Ser Leu Pro 65 70 75 80 Thr Met Leu Arg Ile Phe Leu Phe Asn Val Thr Gly Ile Ser Pro Asp 85 90 95 Ala Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Ser Ala Met Glu 100 105 110 Ala Ser Val Leu Phe Ile Met Ser Ile Asp Arg Leu Ile Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Thr Ser Ile Pro Thr Ser Ala Arg Val Ile Lys 130 135 140 Ile Gly Leu Ile Phe Ala Ala Leu Cys Ile Met Phe Val Leu Pro Phe 145 150 155 160 Pro Phe Ile Leu Lys Arg Leu Lys Phe Cys Lys Lys Ser Leu Leu Ser 165 170 175 His Ser Tyr Cys Leu His Gln Asp Val Met Lys Gln Ala Cys Ser Asp 180 185 190

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069269_0225_SL.TXT

Asn Arg Val Asn Val Ile Tyr Gly Leu Phe Val Ala Leu Ile Ser Leu 195 200 205 Leu Tyr Leu Val Cys Ile Ala Val Ser Tyr Met Leu Ile Leu Lys Ile 210 215 220 Val Leu Gly Ile Thr Ser His Lys Gly Arg Leu Lys Val Leu Asn Thr 225 230 235 240 Cys Ile Ser His Ile Cys Ala Val Phe Ile Phe Tyr Val Pro Ile Val 245 250 255 Thr Leu Ala Ala Leu His Arg Phe Ala Lys His Val Ser Ser Val Val 260 265 270 Arg Val Ile Ile Ala Asp Ile Phe Leu Leu Val Pro Pro Leu Met Asn 275 280 285 Pro Ile Val Tyr Ser Val Lys Ser Gln Gln Ile Arg Asn Arg Ile Leu 290 295 300 Thr Lys Leu Cys Glu Lys Gln Gly

305 310 <210> 1305 <211> 642 <212> DNA <213> Canis familiaris <400> 1305

ttctccaaga atttcttctg atgcttgctt tgcccaagta ttcacagact ctcagctatg 60 gagtaatcaa ttcgtctcat catgcccttc aattgcttta ttgccatctg ccaccctctg 120 agatacacct ctgaccagtg ccagagtcac cagcattgct ttttctttca aaaatgcttt 180 gttgattctc cctttccctt tcactgtaaa acatctaaga aactctaaga agaacctcct 240 tttccattcc tattgcctcc atcagggtat cataaagctg gcctgctctg acaacaagta 300 aatgtcatct atggcttatt tgtggctgtc acaggcatcc tagacttaac atttattttc 360 gtgtcctaca ttatgatact gaaagtagga ttgagcatag caacacagaa gcaaaggctc 420

Page 1472

069269_0225_SL.TXT aaagtcctca acacctgtgt ttctcacatc tgtgctgtgc tcatattcta tgtgcccata ttctctctag ctgttatcta ctggtttgcc aaacacagtt ccccagtcat caagatcctc atggctgatg ttttcctgtt ggtacctcca ttgatgaacc ccattgatta ctgtgtgaaa agccaacaga taaaaagtat agttttaagg aagctgtgtc ag <210> 1306 <211> 90 <212> PRT <213> Canis familiaris

<400> 1306 Val Gly 5 Leu Ser Ile Ala Thr Gln Lys Gln Arg Leu Met Ile 1 Leu Lys 10 15 Lys Val Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Ile Phe 20 25 30 Tyr Val Pro Ile Phe Ser Leu Ala Val Ile Tyr Trp Phe Ala Lys His 35 40 45 Ser Ser Pro Val Ile Lys Ile Leu Met Ala Asp Val Phe Leu Leu Val 50 55 60 Pro Pro Leu Met Asn Pro Ile Asp Tyr Cys Val Lys Ser Gln Gln Ile 65 70 75 80 Lys Ser Ile Val Leu Arg Lys Leu Cys Gln 85 90

<210> 1307 <211> 963 <212> DNA <213> Canis familiaris <400> 1307 atgccaaggg tcaccatggt ggtctggaat aacaataaca ctctggagcc catatttatt ctgaagggat ttcctgggtt ggagtgtgtt cattcttggt tctcaatccc tttctgtctt gcgtacttgg tagcatttat tggtaatgtc accatcctct ctgtcatctg gatagagtcc

480

540

600

642

120

180

Page 1473

069269_0225_SL.TXT

tcactccacc agcccatgta ttactttctt tccatcttgg cactgactga cctaggcatg 240 tccatgtcca cacttcccac catgcttgct gtgttatggc tggatgctag agagatccag 300 gcaagtgctt gctatgctca gctcttcttc atccacacat tcacattcct ggagtcttcg 360 gtgctattgg ccatggcctt cgatcgtttt gttgctatct gccgtccact gcactacacc 420 accatcctta acaacagtgt aataggcaag attggcttgg cctgcttgct aagaagcatg 480 ggagttgtac ttcctacacc tttgctactg agacattatc actactgcca tgtcaatgcc 540 ctttcccatg ccttctgttt gcaccaagac gttctcaaat tgtcctgttc agatgccagg 600 atcagcagtg tctatggact gtgtgtagtc atcactacac tgggcatgga ttcagtcttc 660 atacttcttt cttatgtcct gattttgaat gctgtgctgg gcatagcatc tcatgaagag 720 cggctaaagg cactcaacac atgtgtgtcc catatctgcg tggtgctcat tttctttgtg 780 ccagttattg gggtgtcaat ggtccatcgc tttgggaaac atctgtctcc catagttcac 840 atcatcatgg ctgatattta cttgcttttc cccccagtac ttaaccctat tgtctatagt 900 gtcaggacaa agcagattcg tataagaatt ttccacaagt taagactagg gaggaggctt 960

taa 963 <210> 1308 <211> 320 <212> PRT <213> Canis familiaris

<400> 1308 Met Pro Arg Val 1 Thr 5 Met Val Val Trp Asn Asn Asn Asn Thr Leu Glu 10 15 Pro Ile Phe Ile Leu Lys Gly Phe Pro Gly Leu Glu Cys Val His Ser 20 25 30 Trp Phe Ser Ile Pro Phe Cys Leu Ala Tyr Leu Val Ala Phe Ile Gly 35 40 45 Asn Val Thr Ile Leu Ser Val Ile Trp Ile Glu Ser Ser Leu His Gln 50 55 60 Pro Met Tyr Tyr Phe Leu Ser Ile Leu Ala Leu Thr Asp Leu Gly Met Page 1474

069269_0225_SL.TXT

Ser Met Ser Thr Leu Pro Thr Met Leu Ala Val Leu Trp Leu Asp Ala 85 90 95 Arg Glu Ile Gln Ala Ser Ala Cys Tyr Ala Gln Leu Phe Phe Ile His 100 105 110 Thr Phe Thr Phe Leu Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp 115 120 125 Arg Phe Val Ala Ile Cys Arg Pro Leu His Tyr Thr Thr Ile Leu Asn 130 135 140 Asn Ser Val Ile Gly Lys Ile Gly Leu Ala Cys Leu Leu Arg Ser Met 145 150 155 160 Gly Val Val Leu Pro Thr Pro Leu Leu Leu Arg His Tyr His Tyr Cys 165 170 175 His Val Asn Ala Leu Ser His Ala Phe Cys Leu His Gln Asp Val Leu 180 185 190 Lys Leu Ser Cys Ser Asp Ala Arg Ile Ser Ser Val Tyr Gly Leu Cys 195 200 205 Val Val Ile Thr Thr Leu Gly Met Asp Ser Val Phe Ile Leu Leu Ser 210 215 220 Tyr Val Leu Ile Leu Asn Ala Val Leu Gly Ile Ala Ser His Glu Glu 225 230 235 240 Arg Leu Lys Ala Leu Asn Thr Cys Val Ser His Ile Cys Val Val Leu 245 250 255 Ile Phe Phe Val Pro Val Ile Gly Val Ser Met Val His Arg Phe Gly 260 265 270 Lys His Leu Ser Pro Ile Val His Ile Ile Met Ala Asp Ile Tyr Leu

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275 280 285 Leu Phe Pro Pro Val Leu Asn Pro Ile Val Tyr Ser Val Arg Thr Lys 290 295 300 Gln Ile Arg Ile Arg Ile Phe His Lys Leu Arg Leu Gly Arg Arg Leu 305 310 315 320

<210> 1309 <211> 942 <212> DNA <213> Canis familiaris <400> 1309

atgtctgtct tcaatagctc tgtcctatac cctcgcttcc tcctaacagg cctctcaggc 60 cttgaaagca gatatagctt gatttctatc cccatcttct tggtctatgc cacctcaatt 120 gtaggaaaca ttaccatcct agttatcatc agaactgagt cttccctcca ccaaccaatg 180 tactactttc tatcaatgct ggcactgact gatctgggcc tatccacgac aaccttgcct 240 acaatgttca gtgtcttctg gttccatgcc cgggagatct cctttaatgc ttgcctggtc 300 cagatgtact tcattcatgt tttctcaatt attgagtcag ctgtgctgtt ggccatggcc 360 tttgaccgct ttgtagcaat ccgagagccc ctgcgttatg tgaccattct aaccaatggt 420 gtgatcattg ggattgggtt ggcaattgct ggaagggcct tggctctggt ttttccagct 480 tccttcctcc taaagaggct tcaatatcgt cctgtcaata ttctctccta cccattctgc 540 ctacaccagg atctgataaa aacaactgta tccagtcgtt gggtcagcag catctatggc 600 ctcatggtgg tcatttgctc catgggactt gattcagtgc ttctcctcct ctcctatatc 660 ctcatccttg gcacagtgtt gagtatagcc tccaagacag agaggattaa agcgctcaac 720 acctgcatct cccacatatg tgctgtactc actttctata caccaatgat tgggctatct 780 atgatccgtc gctatgggca gaatgcttcc ccaattgtcc atgtgctcat ggccaatgtc 840 tacttgctgg ttccacccct catgaatcct attgtctaca gtgtcaagac caagcagatt 900 cgtgacagaa tcctcaggaa attcaagcaa cagaaagctt ag 942

<210> 1310 <211> 313

Page 1476

069269_0225_SL.TXT <212> PRT <213> Canis familiaris

<400> 1310 Leu 15 Thr Met 1 Ser Val Phe Asn Ser Ser Val 5 Leu Tyr 10 Pro Arg Phe Leu Gly Leu Ser Gly Leu Glu Ser Arg Tyr Ser Leu Ile Ser Ile Pro Ile 20 25 30 Phe Leu Val Tyr Ala Thr Ser Ile Val Gly Asn Ile Thr Ile Leu Val 35 40 45 Ile Ile Arg Thr Glu Ser Ser Leu His Gln Pro Met Tyr Tyr Phe Leu 50 55 60 Ser Met Leu Ala Leu Thr Asp Leu Gly Leu Ser Thr Thr Thr Leu Pro 65 70 75 80 Thr Met Phe Ser Val Phe Trp Phe His Ala Arg Glu Ile Ser Phe Asn 85 90 95 Ala Cys Leu Val Gln Met Tyr Phe Ile His Val Phe Ser Ile Ile Glu 100 105 110 Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Arg 115 120 125 Glu Pro Leu Arg Tyr Val Thr Ile Leu Thr Asn Gly Val Ile Ile Gly 130 135 140 Ile Gly Leu Ala Ile Ala Gly Arg Ala Leu Ala Leu Val Phe Pro Ala 145 150 155 160 Ser Phe Leu Leu Lys Arg Leu Gln Tyr Arg Pro Val Asn Ile Leu Ser 165 170 175 Tyr Pro Phe Cys Leu His Gln Asp Leu Ile Lys Thr Thr Val Ser Ser 180 185 190

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Arg Trp Val Ser Ser Ile Tyr Gly Leu Met 200 Val Val Ile 205 Cys Ser Met 195 Gly Leu Asp Ser Val Leu Leu Leu Leu Ser Tyr Ile Leu Ile Leu Gly 210 215 220 Thr Val Leu Ser Ile Ala Ser Lys Thr Glu Arg Ile Lys Ala Leu Asn 225 230 235 240 Thr Cys Ile Ser His Ile Cys Ala Val Leu Thr Phe Tyr Thr Pro Met 245 250 255 Ile Gly Leu Ser Met Ile Arg Arg Tyr Gly Gln Asn Ala Ser Pro Ile 260 265 270 Val His Val Leu Met Ala Asn Val Tyr Leu Leu Val Pro Pro Leu Met 275 280 285 Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile Arg Asp Arg Ile 290 295 300 Leu Arg Lys Phe Lys Gln Gln Lys Ala 305 310

<210> 1311 <211> 942 <212> DNA <213> Canis familiaris <400> 1311

atgtcagcct ttaacacttc tgaagtggaa atctctacct tcttcctcat tgggatccca 60 gggatgaagc atgctcacat ttgggtctcc atccccattt gcctcatgta cctccttgcc 120 atcctgggga actgcactat cctctttttc ataaaaacag agacctctct gcatgagcct 180 atgtattatt tcctctccat gctggccttt tctgacctgg gactgtccat ctcctccctt 240 ccaaccatgc tgagaatctt cttgttcaat gccactggaa tctcccctga tgcttgcttt 300 gcccaggagt tcttcattca tggattctca gccatggagt catcagtact tttcatcatg 360 tctatcgatc gcttgatagc catctgcaac cctctgaaat acacctccat tctgaatagt 420

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gtaagagtct ttaaaattgg ccttgtatct gctataaaaa gtctcttatt ggtcttccct 480 ttccccttta ttctgaagag gctgagattc tgtaagaaaa gccttctatc tcactcctac 540 tgtctccatc aggatgtcat gaaactggcc tgttctgaca acagagtcaa tgtcatctac 600 ggactgcttg tggctctaac agctatgtta gacttggtat gcattgctgt gtcttacatg 660 ctgatcatga agattgttct gggcatcacc tcacacaagg gctgtctcaa ggtcctcaac 720 acttgcatct cccacatctg tgctgtgctg atcttttacg tgcctattat taccttggct 780 attattcacc gctttgccaa aaacgtttct ccagttgtta gggtcgtcat agctgatacc 840 ttccttctgg ttccccctct aatgaatccc cttgtgtact ctgtgaagag tcatcagatt 900 agaaatctga ttctcatgaa attatgtgag ataaaaggtt ga 942

<210> 1312 <211> 313 <212> PRT <213> Canis familiaris

<400> 1312 Thr Ser Glu Val Glu Ile Ser Thr Phe Phe Leu Met Ser 1 Ala Phe Asn 5 10 15 Ile Gly Ile Pro Gly Met Lys His Ala His Ile Trp Val Ser Ile Pro 20 25 30 Ile Cys Leu Met Tyr Leu Leu Ala Ile Leu Gly Asn Cys Thr Ile Leu 35 40 45 Phe Phe Ile Lys Thr Glu Thr Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ala Phe Ser Asp Leu Gly Leu Ser Ile Ser Ser Leu 65 70 75 80 Pro Thr Met Leu Arg Ile Phe Leu Phe Asn Ala Thr Gly Ile Ser Pro 85 90 95 Asp Ala Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Ser Ala Met 100 105 110

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Glu Ser Ser 115 Val Leu Phe Ile Met Ser Ile Asp Arg Leu Ile Ala Ile 120 125 Cys Asn Pro Leu Lys Tyr Thr Ser Ile Leu Asn Ser Val Arg Val Phe 130 135 140 Lys Ile Gly Leu Val Ser Ala Ile Lys Ser Leu Leu Leu Val Phe Pro 145 150 155 160 Phe Pro Phe Ile Leu Lys Arg Leu Arg Phe Cys Lys Lys Ser Leu Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ser 180 185 190 Asp Asn Arg Val Asn Val Ile Tyr Gly Leu Leu Val Ala Leu Thr Ala 195 200 205 Met Leu Asp Leu Val Cys Ile Ala Val Ser Tyr Met Leu Ile Met Lys 210 215 220 Ile Val Leu Gly Ile Thr Ser His Lys Gly Cys Leu Lys Val Leu Asn 225 230 235 240 Thr Cys Ile Ser His Ile Cys Ala Val Leu Ile Phe Tyr Val Pro Ile 245 250 255 Ile Thr Leu Ala Ile Ile His Arg Phe Ala Lys Asn Val Ser Pro Val 260 265 270 Val Arg Val Val Ile Ala Asp Thr Phe Leu Leu Val Pro Pro Leu Met 275 280 285 Asn Pro Leu Val Tyr Ser Val Lys Ser His Gln Ile Arg Asn Leu Ile 290 295 300 Leu Met Lys Leu Cys Glu Ile Lys Gly

305 310

Page 1480

069269_0225_SL.TXT <210> 1313 <211> 456 <212> DNA <213> Canis familiaris <400> 1313 attttcatta tcaataagtc atatgttgaa atcaccacct tcctcttggt tggggtgcca gggctggaat atacacacac tctggatctc tatttccatc tgcagcatgt atctttttgt tattctggga aactgcacct ttttgtcatc aagacaaagc tttccttgaa tgagtgtatg tattacttcc tttccatgtt ggccatgtct gacctgggct tgtccctctc ttctctacct accatgggga ggatcttctt attcaatctt ctgaaatttc tgccaaatgc ctgctttccc caggaactct tcatccatgg attcacagta ttttagtccg caatgctcct gatcatgtcg cttgcctgtt tcctagccat ccacaaccct ctgagataca gcttctttct gactattgtc agagttgcca aaataggaat gatcttcttt ttcaga

120

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456 <210> 1314 <211> 111 <212> PRT <213> Canis familiaris <400> 1314

Ile Phe Ile Ile Asn Lys Ser Tyr Val Glu Ile Thr Thr Phe Leu Leu 1 5 10 15 Val Gly Val Pro Gly Leu Glu Tyr Thr His Thr Leu Asp Leu Tyr Phe 20 25 30 His Leu Gln His Val Ser Phe Cys Tyr Ser Gly Lys Leu His Leu Phe 35 40 45 Val Ile Lys Thr Lys Leu Ser Leu Asn Glu Cys Met Tyr Tyr Phe Leu 50 55 60 Ser Met Leu Ala Met Ser Asp Leu Gly Leu Ser Leu Ser Ser Leu Pro 65 70 75 80 Thr Met Gly Arg Ile Phe Leu Phe Asn Leu Leu Lys Phe Leu Pro Asn

85 90 95

Page 1481

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Ala Cys Phe Pro Gln Glu Leu Phe Ile His Gly Phe Thr Val Phe 100 105 110 <210> 1315 <211> 327 <212> DNA <213> Canis familiaris <400> 1315 tttgaagcac tctgccttgt ggtagacttt atgcttattg ctatgtctta catcctgatc 60 ctcaagactg tgctgggaat tgcatcctga aaggatcagc tcaaggtcct caatacttgt 120 gtttcacatt tctgtgcagt gatcatcttc tacttgccca tcatcaacct tgccattgtc 180 catcactttg tctgacatgt ctcacctctc ttcaatatgc tcatggcaag tgttctttta 240 cttgtgcctc caatgatgaa tcccatcgtg tactgtgtga aaactaggca aattagagtg 300 agaattgtag taaaattatg tcagaag 327 <210> 1316 <211> 37 <212> PRT <213> Canis familiaris <400> 1316

Met Leu Met Ala Ser Val Leu Leu Leu Val Pro Pro Met Met Asn Pro 1 5 10 15 Ile Val Tyr Cys Val Lys Thr Arg Gln Ile Arg Val Arg Ile Val Val 20 25 30 Lys Leu Cys Gln Lys

<210> 1317 <211> 309 <212> DNA <213> Canis familiaris <400> 1317 tcaattccat tttgtcttgc atacttggta gcatttatag gcaacatcat catcatctct 60 gttatctgga atgagtcttc actccaccag cccaggtatt atctgctgtc catcctggca 120

Page 1482

069269_0225_SL.TXT ataactgacc tgggcatgtc catgtctata ctccctacaa tattggctat gttatggtgg gaagcccagg aaatcagagg aggagcttgt tttgctcagc ttttcttcat ccacaccttc atgttcttgg agtcttcagt gctgctggcc atggcctttg actgattcat tgctatatgt catccactt <210> 1318 <211> 94 <212> PRT <213> Canis familiaris

<400> 1318 Leu Val Ala Phe Ile Gly Asn Ile Ser 1 Ile Pro Phe Cys 5 Leu Ala Tyr 10 15 Ile Ile Ile Ser Val Ile Trp Asn Glu Ser Ser Leu His Gln Pro Arg 20 25 30 Tyr Tyr Leu Leu Ser Ile Leu Ala Ile Thr Asp Leu Gly Met Ser Met 35 40 45 Ser Ile Leu Pro Thr Ile Leu Ala Met Leu Trp Trp Glu Ala Gln Glu 50 55 60 Ile Arg Gly Gly Ala Cys Phe Ala Gln Leu Phe Phe Ile His Thr Phe 65 70 75 80 Met Phe Leu Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp

85 90 <210> 1319 <211> 480 <212> DNA <213> Canis familiaris <400> 1319 atgcactact gaagcatcct caccaatgat ggtaatattg gcttgggctg cttgctacaa agtacaggag ttgtgatgcc cacccctata ctattgaggt gctaccatca ctgtcgtgct aatgtcctca gccacccctt ttgcttgcat caagatattc tgaaattatc ctgctatgat

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Page 1483

069269_0225_SL.TXT gccagtgtca acaacatcta tggattgtgt gtagtcatta tcacactggg cagagactca ttcctcatcc tcctctctta tgtcctaatt ttccatgctg tactaggcat tgcatctaat gacaagcaac taaaggcact caacacttgt ttatttcatg tatgtgtggt gcttatctgc tctgtacctc taataggggt atgcatggtc catcactttg ggaagcacct gcttcccata gtccacattc tcatggctga catttgcctg cttctcccac cagtacttaa tcccatcatc

240

300

360

420

480 <210> 1320 <211> 135 <212> PRT <213> Canis familiaris <400> 1320

Met 1 Pro Thr Pro Ile 5 Leu Leu Arg Cys Tyr His His Cys Arg Ala Asn 10 15 Val Leu Ser His Pro Phe Cys Leu His Gln Asp Ile Leu Lys Leu Ser 20 25 30 Cys Tyr Asp Ala Ser Val Asn Asn Ile Tyr Gly Leu Cys Val Val Ile 35 40 45 Ile Thr Leu Gly Arg Asp Ser Phe Leu Ile Leu Leu Ser Tyr Val Leu 50 55 60 Ile Phe His Ala Val Leu Gly Ile Ala Ser Asn Asp Lys Gln Leu Lys 65 70 75 80 Ala Leu Asn Thr Cys Leu Phe His Val Cys Val Val Leu Ile Cys Ser 85 90 95 Val Pro Leu Ile Gly Val Cys Met Val His His Phe Gly Lys His Leu 100 105 110 Leu Pro Ile Val His Ile Leu Met Ala Asp Ile Cys Leu Leu Leu Pro 115 120 125 Pro Val Leu Asn Pro Ile Ile

130 135

Page 1484

069269_0225_SL.TXT <210> 1321 <211> 945 <212> DNA <213> Canis familiaris <400> 1321

atggctagct tcaatcacac tggtgttaac catgtagtct tctacctgct gggcattcca 60 ggccgagaag acctacacat atggatttcc attcccttcc tcatctccta tatctttgcc 120 ctccttggaa atggtttgct tatcttcatt atcctcacca agagcagcct ccatgaacct 180 atgtatcttt ttctctgcat gctggctgga gttgacattg tctttgccac aaccacagaa 240 cccaaggcat tggccatttt ctggtgtaat agtaggaaga tctctcttaa tagctgcatt 300 gcccagctct acttccagca ttcctccttt attactgagt caggcatctt gctgattatg 360 gcatttgacc gctacattgc aatatgttac ccactaaggt acaccatgat actcactcac 420 tctctgatag ggaaaattgg tgtggctgtt ttcttgagag cacattgtac aatttttcct 480 atgatattcc tattgaagag gctgactttt tgcagaaata acatcctacc acatacattc 540 tgtgaacaca ttggcttggc caagtatgcc tgtgatgata tccgagtaaa catctggtat 600 ggattttttg tcctaatgtc aacagtgatt ctagatattg tcctcatttt tgtttcctat 660 gctctgatcc tccatgctgt cttccttttc ccttcacgag atgctcgcca caaagctctc 720 aacacctgcg gttcccatgt ctgtgtcatc attctttttt atgggcctgg gatcttctcg 780 gttctcactc agcgctttgg ccatcacatc ccgctacatg tccacatcct gttggccaat 840 gtcagcatgc ttgctccacc tatgctgaac cccatcattt atggggtcaa aacaaaacag 900 atacgagacc aagtgattta tgtgttgttt ccaaagcaga aatga 945

<210> 1322 <211> 314 <212> PRT <213> Canis familiaris <400> 1322

Met Ala Ser Phe Asn His Thr Gly Val Asn His Val Val Phe Tyr Leu 1 5 10 15 Leu Gly Ile Pro Gly Arg Glu Asp Leu His Ile Trp Ile Ser Ile Pro

20 25 30

Page 1485

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Phe Leu Ile 35 Ser Tyr Ile Phe Ala Leu Leu Gly Asn Gly Leu Leu Ile 40 45 Phe Ile Ile Leu Thr Lys Ser Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Cys Met Leu Ala Gly Val Asp Ile Val Phe Ala Thr Thr Thr Glu 65 70 75 80 Pro Lys Ala Leu Ala Ile Phe Trp Cys Asn Ser Arg Lys Ile Ser Leu 85 90 95 Asn Ser Cys Ile Ala Gln Leu Tyr Phe Gln His Ser Ser Phe Ile Thr 100 105 110 Glu Ser Gly Ile Leu Leu Ile Met Ala Phe Asp Arg Tyr Ile Ala Ile 115 120 125 Cys Tyr Pro Leu Arg Tyr Thr Met Ile Leu Thr His Ser Leu Ile Gly 130 135 140 Lys Ile Gly Val Ala Val Phe Leu Arg Ala His Cys Thr Ile Phe Pro 145 150 155 160 Met Ile Phe Leu Leu Lys Arg Leu Thr Phe Cys Arg Asn Asn Ile Leu 165 170 175 Pro His Thr Phe Cys Glu His Ile Gly Leu Ala Lys Tyr Ala Cys Asp 180 185 190 Asp Ile Arg Val Asn Ile Trp Tyr Gly Phe Phe Val Leu Met Ser Thr 195 200 205 Val Ile Leu Asp Ile Val Leu Ile Phe Val Ser Tyr Ala Leu Ile Leu 210 215 220 His Ala Val Phe Leu Phe Pro Ser Arg Asp Ala Arg His Lys Ala Leu 225 230 235 240

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Asn Thr Cys Gly Ser 245 His Gly Ile Phe Ser 260 Val Leu His Val His 275 Ile Leu Leu Leu Asn 290 Pro Ile Ile Tyr Val 305 Ile Tyr Val Leu Phe 310

Val Cys Val Ile 250 Ile Thr Gln Arg 265 Phe Gly Ala Asn 280 Val Ser Met Gly 295 Val Lys Thr Lys Pro Lys Gln Lys

Leu Phe Tyr Gly 255 Pro His His Ile 270 Pro Leu Leu Ala 285 Pro Pro Met Gln 300 Ile Arg Asp Gln

<210> 1323 <211> 939 <212> DNA <213> Canis familiaris <400> 1323 atgatatacc acaataggag ggtctggaag gggcccatgc ttactgggca atgccacaat cccatgttct attttctggc gtgccccgaa tgttgggaat gtggcccaga tgtttttgat atggcctttg atcgctatgt tcccgagtgc tggtcggcat cccatggtct tcctcatcta tactgtgagc acatgggcat tatgggcttt tcgtggtttc atgtacattc tccgagctgt catttttcac ccagccacat ctggatctcc ctgcctttct tttgctagtc atcaagatgg tctcctttca actattgatt cttctggttt gatgctcatg ccatactttt actggcatgg ggccatctgt gctcccctcc cagcatgtgc attgtgattc ccgcctaccc ttctgtcagg tgccaaactc tcctgtggaa cttctttgtc ctaaacctgg ctttcgcctc ccatcacagg tcttcctcgt tggaatccct gctctgttta ccttgtggct agcagaccct gcggagggag tggccctttc cacaacctct agattaactt tggagcttgt aggctgaggt cttgctggct actatacaac catcttgaca gtccagttgt gctgacactt ctcacgtgat agctcactcc acatccgtgt caatgccatc tccttattgg catctcctac atgctcggct aaaagcactc

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Page 1487

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agcacatgtg gttctcacgt tggggtcatc tgtgttttct atatcccctc agtgttctcc 780 ttcctcactc accgatttgg acacaacata ccacgctaca ttcacattct tgttgccaac 840 ctctatttgg ttatcccacc atcactcaac cccatcattt atggtgtaag gaccaaacag 900 attcgagagc gagtgctcca tgtctttata aaaaaataa 939

<210> 1324 <211> 312 <212> PRT <213> Canis familiaris

<400> 1324 His Asn 5 Arg Ser Ile Phe His Pro Ala Thr Phe Phe Leu Met 1 Ile Tyr 10 15 Val Gly Ile Pro Gly Leu Glu Gly Ala His Ala Trp Ile Ser Leu Pro 20 25 30 Phe Cys Ser Val Tyr Leu Val Ala Leu Leu Gly Asn Ala Thr Ile Leu 35 40 45 Leu Val Ile Lys Met Glu Gln Thr Leu Arg Arg Glu Pro Met Phe Tyr 50 55 60 Phe Leu Ala Leu Leu Ser Thr Ile Asp Leu Ala Leu Ser Thr Thr Ser 65 70 75 80 Val Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Glu Ile Asn 85 90 95 Phe Gly Ala Cys Val Ala Gln Met Phe Leu Ile His Thr Phe Thr Gly 100 105 110 Met Glu Ala Glu Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 Ile Cys Ala Pro Leu His Tyr Thr Thr Ile Leu Thr Ser Arg Val Leu 130 135 140

Val Gly Ile Ser Met

Cys

Ile Val

Ile Arg

Pro Val Val

Leu Thr Leu

Page 1488

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145 150 Pro 170 155 Phe Cys 160 Pro Met Val Phe Leu 165 Ile Tyr Arg Leu Gln Ala His Val 175 Ile Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ser Cys 180 185 190 Gly Asn Ile Arg Val Asn Ala Ile Tyr Gly Leu Phe Val Val Ser Phe 195 200 205 Phe Val Leu Asn Leu Val Leu Ile Gly Ile Ser Tyr Met Tyr Ile Leu 210 215 220 Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg Leu Lys Ala Leu 225 230 235 240 Ser Thr Cys Gly Ser His Val Gly Val Ile Cys Val Phe Tyr Ile Pro 245 250 255 Ser Val Phe Ser Phe Leu Thr His Arg Phe Gly His Asn Ile Pro Arg 260 265 270 Tyr Ile His Ile Leu Val Ala Asn Leu Tyr Leu Val Ile Pro Pro Ser 275 280 285 Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg 290 295 300 Val Leu His Val Phe Ile Lys Lys 305 310 <210> 1325 <211> 939 <212> DNA <213> Canis familiaris <400> 1325 atgctttacc ccaacaggag catttttcac ccagccacat tcttcctcgt tggaatccct ggtctggaag gggcccatgc ctggatctcc ctgcctttct gttctgttta ccttgtggct

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ttactgggca atgccacgat tttgctagtc atcaagatgg agcagaccct gcggagggag 180 cccatgttct attttctggc cctcctttca actattgatt tggccctttc cacaacctct 240 gtgccccgaa tgttgggaat cttctggttt gatgctcatg agattacctt tggagcttgt 300 gtggcccaga tgtttttaat ccatgccttc actggcatgg aggccgaggt cctggtagcc 360 atggcctttg atcgctatgt ggccatctgt gctcccctcc actatacaac catcttgaca 420 tcccgagtgc tggtcggcat cagcatgtgc attgtgattc gtccagtttt atttacactt 480 cccatagtct atctcatcta ccgcctaccc ttctgtcagg ctcatgtaat agctcactcc 540 tactgtgagc acatgggcat tgccaaactc tcctgtggaa acatccgtgt caatgccatc 600 tatgggctct ttgtggtctc tctctttctg ctgaacctgg tcctaattgg catctcttat 660 gtgtacattc tccgagctgt ctttcgcctc ccatcacagg atgctcggct aaaagcactc 720 agcacatgtg gttctcacgt tggggtcatc tgtgttttct atatcccctc agtgttctcc 780 ttcctcactc accgatttgg acataacata ccacgctaca ttcacattct tgttgccaac 840 ctctatttgg ttatcccacc atcactcaac cccatcattt atggtgtaag gaccaaacag 900 attcgagagc gagtgctccg tgtctttgct aaaaagtag 939

<210> 1326 <211> 312 <212> PRT <213> Canis familiaris <400> 1326

Met 1 Leu Tyr Pro Asn 5 Arg Ser Ile Phe His Pro Ala Thr Phe 10 Phe 15 Leu Val Gly Ile Pro Gly Leu Glu Gly Ala His Ala Trp Ile Ser Leu Pro 20 25 30 Phe Cys Ser Val Tyr Leu Val Ala Leu Leu Gly Asn Ala Thr Ile Leu 35 40 45 Leu Val Ile Lys Met Glu Gln Thr Leu Arg Arg Glu Pro Met Phe Tyr 50 55 60

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Phe 65 Leu Ala Leu Leu Ser Thr Ile Asp Leu Ala Leu Ser Thr Thr Ser 70 75 80 Val Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Glu Ile Thr 85 90 95 Phe Gly Ala Cys Val Ala Gln Met Phe Leu Ile His Ala Phe Thr Gly 100 105 110 Met Glu Ala Glu Val Leu Val Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 Ile Cys Ala Pro Leu His Tyr Thr Thr Ile Leu Thr Ser Arg Val Leu 130 135 140 Val Gly Ile Ser Met Cys Ile Val Ile Arg Pro Val Leu Phe Thr Leu 145 150 155 160 Pro Ile Val Tyr Leu Ile Tyr Arg Leu Pro Phe Cys Gln Ala His Val 165 170 175 Ile Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ser Cys 180 185 190 Gly Asn Ile Arg Val Asn Ala Ile Tyr Gly Leu Phe Val Val Ser Leu 195 200 205 Phe Leu Leu Asn Leu Val Leu Ile Gly Ile Ser Tyr Val Tyr Ile Leu 210 215 220 Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg Leu Lys Ala Leu 225 230 235 240 Ser Thr Cys Gly Ser His Val Gly Val Ile Cys Val Phe Tyr Ile Pro 245 250 255 Ser Val Phe Ser Phe Leu Thr His Arg Phe Gly His Asn Ile Pro Arg 260 265 270

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Tyr Ile His Ile Leu Val Ala Asn Leu Tyr Leu Val Ile Pro Pro Ser 275 280 285 Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg 290 295 300 Val Leu Arg Val Phe Ala Lys Lys 305 310

<210> 1327 <211> 732 <212> DNA <213> Canis familiaris <400> 1327 gtgttcaatt tgccaacatt ttttttttct ttctaggaat gaattggatc tcctcatatt 60 ccagccaaat tcagaattcc tcatcaaccc atcattctca ctttttcttt taggcatgcc 120 agggcttgag actaccaatg cctggatttc cttgctcttc tgttgtattt agattttagt 180 tcttatttga atgtaacaat ttaaatagtg atacaggcag acagaatcct tgtgacccct 240 gtattatttc tggttctata tttggctttc tccacatcct tggcaccaca tatcttttgg 300 ttgaacactc aagagattgg ctttggggtc tctggggccc agatgtttct catacacagg 360 aatggtgtct tcaggacttc tgcaatgact tttgaccatt cagtggcctt ctgtgcacca 420 ctccactaca caatcatcgt gatagtttat tgcccagaaa acagtgagca catgagcatt 480 gccaagttgg cttatgccaa ttttcaaatc aatgctatct gtggtctctt agccactttt 540 ttccttgtcc tcatcctggt actgctggga atctcctatg gctacatcct ctgggttgta 600 ttccacctca aattacaaat gcccatcaca agacactgag caattgtagc tcccatgcta 660 cagtcatgtt tgttttctac acaccctctc tcttcatttt ttaaaaaaat gtactctaca 720 tggatagaac tg 732 <210> 1328 <211> 56 <212> PRT <213> Canis familiaris <400> 1328

Cys Ser Ile Cys Gln His Phe Phe Phe Leu Ser Arg Asn Glu Leu Asp

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1 5 10 15 Leu Leu Ile Phe Gln Pro Asn Ser Glu Phe Leu Ile Asn Pro Ser Phe 20 25 30 Ser Leu Phe Leu Leu Gly Met Pro Gly Leu Glu Thr Thr Asn Ala Trp 35 40 45 Ile Ser Leu Leu Phe Cys Cys Ile

50 55 <210> 1329 <211> 936 <212> DNA <213> Canis familiaris <400> 1329

atgtctcttt ccaatcaaac tcagctccac ccttcctcct tcttgctggt aggaatccca 60 ggactagaaa cagtccacat ctggattggc tttccctttt gtgccatgta tctgattgca 120 ctcataggaa acttcaccat cttgttcatc atccagactg agcacagcct ccaccagccc 180 atgttttact ttctagcaat actggctacc attgacctgg gactgtccac aaccactatc 240 cctaagatgc tgggcatatt ctggtttggc ctcagggaga tcacttttga tgactgcctt 300 actcagatgt ttttcattca catttttact ggcatggaat caggagtcct tcttgccatg 360 gcttatgacc gttatgtagc tatctgtaac cctcttcgtt ataacacaat ccttactaac 420 aaagtagtat ctcttattgg ttttggggtg gttgcgagat cttttttcat tgtactcccc 480 tttgtattcc tcatcttgag actgcccttt tgtgaacatc atgtcatctc ccacacatac 540 tgtgagcata tgggtcttgc gcgtctggcc tgtgcaagta tcagaatcaa tattatatat 600 ggtctgggga ccatagcaat cctggggctt gacatcatgg ccatttctct gtcctatgtc 660 caaattctct gtgccgtttt ccatttcccc tcccatgagg ccaggctcaa gtctctcagc 720 acctgtggct cccatgtctg tgtaattttg gctttttaca ccccagccct cttctctttt 780 ttgacacatc gttttggcca aaatgttccc cactacatcc atatccttct ggccaatctg 840 tatgtagtga ttccaccaat gctcaaccct gtcatctatg gagtcagaac caagcagatt 900 catgaaaggg tgctcagaat atttagccag aagtaa 936

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069269_0225_SL.TXT <210> 1330 <211> 311 <212> PRT <213> Canis familiaris

<400> 1330 Leu Met 1 Ser Leu Ser Asn 5 Gln Thr Gln Leu His Pro Ser Ser Phe Leu 10 15 Val Gly Ile Pro Gly Leu Glu Thr Val His Ile Trp Ile Gly Phe Pro 20 25 30 Phe Cys Ala Met Tyr Leu Ile Ala Leu Ile Gly Asn Phe Thr Ile Leu 35 40 45 Phe Ile Ile Gln Thr Glu His Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Ile Leu Ala Thr Ile Asp Leu Gly Leu Ser Thr Thr Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Gly Leu Arg Glu Ile Thr Phe 85 90 95 Asp Asp Cys Leu Thr Gln Met Phe Phe Ile His Ile Phe Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Asn Thr Ile Leu Thr Asn Lys Val Val Ser 130 135 140 Leu Ile Gly Phe Gly Val Val Ala Arg Ser Phe Phe Ile Val Leu Pro 145 150 155 160 Phe Val Phe Leu Ile Leu Arg Leu Pro Phe Cys Glu His His Val Ile 165 170 175

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Ser His Thr Tyr 180 Cys Glu His Met Gly Leu Ala Arg Leu Ala Cys Ala 185 190 Ser Ile Arg Ile Asn Ile Ile Tyr Gly Leu Gly Thr Ile Ala Ile Leu 195 200 205 Gly Leu Asp Ile Met Ala Ile Ser Leu Ser Tyr Val Gln Ile Leu Cys 210 215 220 Ala Val Phe His Phe Pro Ser His Glu Ala Arg Leu Lys Ser Leu Ser 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Ile Leu Ala Phe Tyr Thr Pro Ala 245 250 255 Leu Phe Ser Phe Leu Thr His Arg Phe Gly Gln Asn Val Pro His Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Ile Pro Pro Met Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile His Glu Arg Val 290 295 300 Leu Arg Ile Phe Ser Gln Lys 305 310

<210> 1331 <211> 939 <212> DNA <213> Canis familiaris <400> 1331 atgttccctc ccaataacac ccaattccac ctcttttcct tcttgttgct ggggatccca gaaatggaaa cactgcacct ctggattggc tttccctttt gtgctgtgta cacagttgca ctcattggga acttcactat tctgtttgtc atccaggctg agagcagcct acaccagcct atgttctatt tcctggccat gttggctact attgatttgg gtctgtccac agctaccatc cccaagatgc ttggaatctt ctggttcaac ctcagagaga tcatctttgg agcttgcctc

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gtgcaaatgt ttttcattca cagcttcaca cttatggagt cagctgtcct gttggcaatg 360 gcttatgacc gctacgtggc catctgcaac ccacttcgat atagcaccat cctcaccaac 420 agggttgttt ctgtgattgg tgttggtgtg ttagtgaggg catttatttt tgtgattcct 480 tttgtatttc tgattttgcg attgcccttc tgtgggaatc gtgtcattgc ccatacctat 540 tgtgaacaca tgggtcttgc tcgtctctct tgtgccagca tcaagatcaa tattatttat 600 ggcttatgtg caatttgtaa tctagtattt gacatcatag gcattgccct ttcttatgtt 660 cagatactgc gagctgtttt ccgtcttcct tctcgtgaag cccgactcaa atccctcagc 720 acgtgcggtt ctcatgtttg tgtaattctt gccttctata caccggccct cttttccttt 780 atgacacatc gctttggaca taatgttccc cgctatatcc acatactcct ggctaatctt 840 tatgtcatag tgccaccaat gctcaaccct gtcatatatg gagtcaggac caagcagatc 900 tatgaccggg tgaagaaact attattacag aaaccatga 939

<210> 1332 <211> 312 <212> PRT <213> Canis familiaris <400> 1332

Met 1 Phe Pro Pro Asn Asn 5 Thr Gln Phe His 10 Leu Phe Ser Phe Leu 15 Leu Leu Gly Ile Pro Glu Met Glu Thr Leu His Leu Trp Ile Gly Phe Pro 20 25 30 Phe Cys Ala Val Tyr Thr Val Ala Leu Ile Gly Asn Phe Thr Ile Leu 35 40 45 Phe Val Ile Gln Ala Glu Ser Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Thr Ile Asp Leu Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Arg Glu Ile Ile Phe 85 90 95

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Gly Ala Cys Leu Val Gln Met Phe Phe Ile His Ser Phe Thr Leu Met 100 105 110 Glu Ser Ala Val Leu Leu Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn Arg Val Val Ser 130 135 140 Val Ile Gly Val Gly Val Leu Val Arg Ala Phe Ile Phe Val Ile Pro 145 150 155 160 Phe Val Phe Leu Ile Leu Arg Leu Pro Phe Cys Gly Asn Arg Val Ile 165 170 175 Ala His Thr Tyr Cys Glu His Met Gly Leu Ala Arg Leu Ser Cys Ala 180 185 190 Ser Ile Lys Ile Asn Ile Ile Tyr Gly Leu Cys Ala Ile Cys Asn Leu 195 200 205 Val Phe Asp Ile Ile Gly Ile Ala Leu Ser Tyr Val Gln Ile Leu Arg 210 215 220 Ala Val Phe Arg Leu Pro Ser Arg Glu Ala Arg Leu Lys Ser Leu Ser 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Ile Leu Ala Phe Tyr Thr Pro Ala 245 250 255 Leu Phe Ser Phe Met Thr His Arg Phe Gly His Asn Val Pro Arg Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Ile Val Pro Pro Met Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Tyr Asp Arg Val 290 295 300

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Lys Lys Leu Leu Leu Gln Lys Pro 305 310 <210> 1333 <211> 942 <212> DNA <213> Canis familiaris <400> 1333

atgacctcac ttaatactac cctatttcat ccctactctt tcttccttct ggggattcct 60 gggttggaac atatacatat ctggattggt ttccctttct ttgctgtgta cctgacagct 120 gttcttggaa atatcataat tctttctgtg attgacactg agagcagcct ccaccagccc 180 atgttctact tcttggccat tctgtcatct atcgatctgg gcctgtcaac atccaccatc 240 cccaagatgc ttggcatctt ctggttcaac ctgagagaaa tctcctttga aggatgcctc 300 atccagatgt tcttcatcca cctatacact ggcatggagt cagctgtgct tgtggctatg 360 gcctatgatc gctatgtggc catctgtaac cctcttcagt acacattggt gctgacaaac 420 agggtggtag tcgtcattgc attgataatc ctgctgagac ctttgtcttt tgccataccc 480 tttgttctac tcatcctacg gttaccattt tgtggacatc aaattattcc tcacacttac 540 tgtgagcaca tgggcattgc ccgcctgtct tgtgccagca tcaggatcaa catcatctat 600 ggcttatgtg ccatctctat tctggtgttt gacatcatag ctattgtcat ttcttatgtc 660 cagattcttc gtgctgtctt tcgactgcct tcccacgatg cccggctcaa agcactcagc 720 acctgtggct ctcatgtatg tgtcatgctg gctttctaca ctcctgcatt tttttcattt 780 atgacccaca ggtttggcca gaatatacca cgctatatcc acatcctttt ggctaatttc 840 tacgtagtca ttccacctgc cctcaaccct gtaatctacg gtgtcagaac aaaacagatt 900 agagaaaagg tgctgaaagt cttttccaag aaaaatacat aa 942

<210> 1334 <211> 313 <212> PRT <213> Canis familiaris <400> 1334

Met Thr Ser Leu Asn Thr Thr Leu Phe His Pro Tyr Ser Phe Phe Leu 1 5 10 15

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Leu Gly Ile Pro Gly Leu 20 Glu His Ile His Ile Trp Ile Gly Phe Pro 25 30 Phe Phe Ala Val Tyr Leu Thr Ala Val Leu Gly Asn Ile Ile Ile Leu 35 40 45 Ser Val Ile Asp Thr Glu Ser Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Ile Leu Ser Ser Ile Asp Leu Gly Leu Ser Thr Ser Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Arg Glu Ile Ser Phe 85 90 95 Glu Gly Cys Leu Ile Gln Met Phe Phe Ile His Leu Tyr Thr Gly Met 100 105 110 Glu Ser Ala Val Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Gln Tyr Thr Leu Val Leu Thr Asn Arg Val Val Val 130 135 140 Val Ile Ala Leu Ile Ile Leu Leu Arg Pro Leu Ser Phe Ala Ile Pro 145 150 155 160 Phe Val Leu Leu Ile Leu Arg Leu Pro Phe Cys Gly His Gln Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ser Cys Ala 180 185 190 Ser Ile Arg Ile Asn Ile Ile Tyr Gly Leu Cys Ala Ile Ser Ile Leu 195 200 205 Val Phe Asp Ile Ile Ala Ile Val Ile Ser Tyr Val Gln Ile Leu Arg 210 215 220

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Ala Val Phe Arg Leu Pro Ser His Asp Ala Arg Leu Lys Ala Leu Ser 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Met Leu Ala Phe Tyr Thr Pro Ala 245 250 255 Phe Phe Ser Phe Met Thr His Arg Phe Gly Gln Asn Ile Pro Arg Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Phe Tyr Val Val Ile Pro Pro Ala Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Lys Val 290 295 300 Leu Lys Val Phe Ser Lys Lys Asn Thr

305

310 <210> 1335 <211> 960 <212> DNA <213> Canis <400> 1335 atgctaggta ggcattcctg cttttggccc catgagccaa acagctgtac gcctgcctca ctggccatgg ctgacacagg ctcagtcctc cacacctact familiaris tgtcagcata ggctggaggc tcctgggaaa tgtacctctt caaaactcct ctcaagtgtt cttttgaccg ctgtaatagg acccctttct gtgagttcat caataagact agcccacatc ctgttctctt cctctgcatg tagccttttc cctgattcac ttatatagcc ggggatgggt gttacgttgg ggccctcatt gatgtccatc tggatctcca ctgtttatca ctggctgtgg tggttccatg tcttgctcca atttgtaacc ctaggtatag cttccctact aagattgcct catcaatctt tccccttttg tcaagacaga ctgatcttat atggagaaat ccatggaatc cattaagaca tactccgtgg gcagaaccaa gtgctgagac cattctcatt tgtggtctac ctccagcctc tgtgtgtact tcgtattgaa gggcttcttc ttcagctatt cacggtactt tattatttcc gagaatccgt

120

180

240

300

360

420

480

540

600

Page 1500

069269_0225_SL.TXT agagcataca gcctcattgt tgccttcctt actggtgggg tggacttcat attgattatt tgttcttatg ttctcatact ccacacagtc ttccacctcc catccaagga ggcccgactc aagaccttgg gcacctgtgg ctcccatatc tgtgtcatct tagtgtctta tactccagca ttcttctctt tcctcaccca caggtttggg catcatgtgg ctccccatgt ccacatattt gtggccaaca tctatcttct ggtcccaccc atggtgaacc ctattatcta tggagtaagg accaagagga tacgagacag gttccttaaa tttttcagtt tttcaaagtc tgtgaactaa

660

720

780

840

900

960 <210> 1336 <211> 319 <212> PRT <213> Canis familiaris

<400> 1336 Ser Ala Tyr 5 Asn Met 1 Leu Gly Met Phe Ile Leu Ile 20 Gly Ile Pro Gly Ser Ile Pro 35 Phe Cys Val Val Tyr 40 Ser Leu 50 Leu Phe Ile Ile Lys 55 Thr Tyr 65 Leu Phe Leu Cys Met 70 Leu Ala Thr Ala Val Pro Lys 85 Leu Leu Ser Ile Arg Ile Glu 100 Ala Cys Leu Thr Ser Thr Met 115 Glu Ser Gly Phe Phe 120 Ile Ala Ile Cys Asn Pro Leu Arg

Lys Thr 10 Asp Val His Pro Ser 15 Ile Leu 25 Glu Ala Ala His Ile 30 Trp Ile Leu Leu Ala Leu Leu 45 Gly Asn Cys Asp Ser Ser Leu 60 His Glu Pro Met Val Ala Asp 75 Leu Ile Val Cys Thr 80 Leu Phe 90 Trp Phe His Asp Gly 95 Glu Gln 105 Val Phe Leu Ile His 110 Ser Cys Leu Ala Met Ala Phe 125 Asp Arg Tyr His Ser Ala Ile Leu Thr Gln Ala

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130 135 140

Val Ile Gly Gly Met Gly Leu Gly Ile Val Leu Arg Gly Thr Val Leu 145 150 155 160 Leu Ser Pro His Pro Phe Leu Leu Arg Trp Leu Pro Tyr Cys Arg Thr 165 170 175 Asn Ile Ile Ser His Thr Tyr Cys Glu Phe Met Ala Leu Ile Lys Ile 180 185 190 Ala Cys Ala Glu Thr Arg Ile Arg Arg Ala Tyr Ser Leu Ile Val Ala 195 200 205 Phe Leu Thr Gly Gly Val Asp Phe Ile Leu Ile Ile Cys Ser Tyr Val 210 215 220 Leu Ile Leu His Thr Val Phe His Leu Pro Ser Lys Glu Ala Arg Leu 225 230 235 240 Lys Thr Leu Gly Thr Cys Gly Ser His Ile Cys Val Ile Leu Val Ser 245 250 255 Tyr Thr Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His His 260 265 270 Val Ala Pro His Val His Ile Phe Val Ala Asn Ile Tyr Leu Leu Val 275 280 285 Pro Pro Met Val Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Arg Ile 290 295 300 Arg Asp Arg Phe Leu Lys Phe Phe Ser Phe Ser Lys Ser Val Asn 305 310 315

<210> 1337 <211> 858 <212> DNA <213> Canis familiaris

Page 1502

069269_0225_SL.TXT <400> 1337 atgtggattg gctttccctt ttgtgctgtg tacatgattg cacttctagg aaacctcact 60 attctgtttg tcatccaggc tgagagcagc ctacaccaac caatgttcta cttcctagcc 120 atgttggcta ctattgattt gggtctgtcc acaactacca tccccaagat gcttggaatc 180 ttctggttta gtctcaggga gatactcttt gatgcttgtc tcactcagat gttttttatc 240 cacaacttca ctggtatgga gtcagctgtc ctgttggcaa tggcttatga ccgctacgtg 300 gccatctgca acccacttcg atatagcacc atcctcacca acagggttgt ttctgtgatt 360 ggtgttggtg tgttagtgag ggcatttatt tctgtgattc catttgtgtt tctgattttg 420 cgatcgccct tctgtgggaa tcgtgtcatt gcccatacct attgtgaaca tatgggtctt 480 gctcgtctct cttgtgccag catcaagatc aatattattt atggcttatg tgcaatttgt 540 aatctagtat ttgacatcat aggcattgtc ctttcttatg ttcagatact gcgagctgtt 600 ttccgtcttc cttctcgtga agcccgactc aaatccctca gcacatgcgg ttctcatgtt 660 tgtgtaattc ttgccttcta tacaccagcc ctcttttcct ttatgacaca tcgctttggc 720 cgaaatgttc cccgctatat ccacatactc ctggccaatc tctatgtcat agtgccacca 780 atgctcaacc ctgtcatata tggagtcagg accaagcaga tctatgaccg ggtgaagaaa 840 atattattgc aaagataa 858 <210> 1338 <211> 285 <212> PRT <213> Canis familiaris <400> 1338

Met Trp Ile Gly Phe Pro Phe Cys Ala Val Tyr Met Ile Ala Leu Leu 1 5 10 15 Gly Asn Leu Thr Ile Leu Phe Val Ile Gln Ala Glu Ser Ser Leu His 20 25 30 Gln Pro Met Phe Tyr Phe Leu Ala Met Leu Ala Thr Ile Asp Leu Gly 35 40 45 Leu Ser Thr Thr Thr Ile Pro Lys Met Leu Gly Ile Phe Trp Phe Ser

50 55 60

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Leu Arg 65 Glu Ile Leu Phe 70 Asp Ala Cys Leu Thr Gln Met Phe Phe Ile 75 80 His Asn Phe Thr Gly Met Glu Ser Ala Val Leu Leu Ala Met Ala Tyr 85 90 95 Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Ser Thr Ile Leu 100 105 110 Thr Asn Arg Val Val Ser Val Ile Gly Val Gly Val Leu Val Arg Ala 115 120 125 Phe Ile Ser Val Ile Pro Phe Val Phe Leu Ile Leu Arg Ser Pro Phe 130 135 140 Cys Gly Asn Arg Val Ile Ala His Thr Tyr Cys Glu His Met Gly Leu 145 150 155 160 Ala Arg Leu Ser Cys Ala Ser Ile Lys Ile Asn Ile Ile Tyr Gly Leu 165 170 175 Cys Ala Ile Cys Asn Leu Val Phe Asp Ile Ile Gly Ile Val Leu Ser 180 185 190 Tyr Val Gln Ile Leu Arg Ala Val Phe Arg Leu Pro Ser Arg Glu Ala 195 200 205 Arg Leu Lys Ser Leu Ser Thr Cys Gly Ser His Val Cys Val Ile Leu 210 215 220 Ala Phe Tyr Thr Pro Ala Leu Phe Ser Phe Met Thr His Arg Phe Gly 225 230 235 240 Arg Asn Val Pro Arg Tyr Ile His Ile Leu Leu Ala Asn Leu Tyr Val 245 250 255 Ile Val Pro Pro Met Leu Asn Pro Val Ile Tyr Gly Val Arg Thr Lys 260 265 270

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Gln Ile Tyr Asp Arg Val Lys Lys Ile Leu Leu Gln Arg 275 280 285 <210> 1339 <211> 936 <212> DNA <213> Canis familiaris <400> 1339

atgttccaca caaatacttc cactttccac ccagaaacct tttatcttat aggcattcca 60 ggacttgagg gttcccatgg ctggatctcc ctgccttttt gctccattta cttaatggct 120 ctgttgggca atgctacaat tttgctgatc atctggtctg atcgtgctct gcgggatcct 180 atgttctact ttctggccat cttatcagcc atagatttgg ccctttccac atcctcagtg 240 ccccgaatgt tgggtatctt ctggtttgat gcacatgaaa ttggttttgg aacatgtgtg 300 gctcagatgt tcctgataca cacttttaca ggaatggagt ctgccgttct gctggctatg 360 gcttttgacc gctatgtggc tatctgtgta ccactcctct acacaaccat cctgacaccc 420 cgagtgctag caggcattgg ggtgggtatt ataatgcgcc ctgtcctgct catgttgccc 480 attctctacc taacccatcg tctgcccttc tgtgagacac gaattattgc ccattcctac 540 tgtgagcaca tgggcattgc caagttggcc tgtgccaaca ttagagttaa tgccatttat 600 ggactctttg tggcctcttt tcttattttg gatgtggcgc tagttggaat ctcttatgcc 660 tacatccttc gagcagtttt ccgcctccca tctcaagatg ctcgtcacaa agctttgagc 720 acatgtgggt cacatgttgg ggtcatgtgt gttttctata caccttctct cttctccttc 780 ctcacccacc gatttggcaa aaaaattccc cgttatgtcc acatcctagt tgccaatctc 840 tatgtggtct tcccacctgc cctcaatcct attatctatg gtgtgaggac aaagcagatt 900 cgtgagcgtg taatccatac tttcacctca aagtag 936

<210> 1340 <211> 311 <212> PRT <213> Canis familiaris <400> 1340

Met Phe His Thr Asn Thr Ser Thr Phe His Pro Glu Thr Phe Tyr Leu

Page 1505

0 6926 9_02 25_S L.TX T 1 5 10 15 Ile Gly Ile Pro Gly Leu Glu Gly Ser His Gly Trp Ile Ser Leu Pro 20 25 30 Phe Cys Ser Ile Tyr Leu Met Ala Leu Leu Gly Asn Ala Thr Ile Leu 35 40 45 Leu Ile Ile Trp Ser Asp Arg Ala Leu Arg Asp Pro Met Phe Tyr Phe 50 55 60 Leu Ala Ile Leu Ser Ala Ile Asp Leu Ala Leu Ser Thr Ser Ser Val 65 70 75 80 Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Glu Ile Gly Phe 85 90 95 Gly Thr Cys Val Ala Gln Met Phe Leu Ile His Thr Phe Thr Gly Met 100 105 110 Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Val Pro Leu Leu Tyr Thr Thr Ile Leu Thr Pro Arg Val Leu Ala 130 135 140 Gly Ile Gly Val Gly Ile Ile Met Arg Pro Val Leu Leu Met Leu Pro 145 150 155 160 Ile Leu Tyr Leu Thr His Arg Leu Pro Phe Cys Glu Thr Arg Ile Ile 165 170 175 Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ala Cys Ala 180 185 190 Asn Ile Arg Val Asn Ala Ile Tyr Gly Leu Phe Val Ala Ser Phe Leu 195 200 205 Ile Leu Asp Val Ala Leu Val Gly Ile Ser Tyr Ala Tyr Ile Leu Arg

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210 215 220

Ala Val 225 Phe Arg Leu Pro Ser Gln Asp Ala Arg His Lys Ala Leu Ser 230 235 240 Thr Cys Gly Ser His Val Gly Val Met Cys Val Phe Tyr Thr Pro Ser 245 250 255 Leu Phe Ser Phe Leu Thr His Arg Phe Gly Lys Lys Ile Pro Arg Tyr 260 265 270 Val His Ile Leu Val Ala Asn Leu Tyr Val Val Phe Pro Pro Ala Leu 275 280 285 Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg Val 290 295 300 Ile His Thr Phe Thr Ser Lys

305 310

<210> 1341 <211> 921 <212> DNA <213> Canis familiaris <400> 1341 atggtgcctt ctaatgacac acaattccat cccaatttct ttctcttgct gggaattcca 60 gggctggaag acatgcatat gtggattggt tttccatttt gtgttatata tctgacagcc 120 ttattgggaa atcttacaat tctttttgtg attcagactg atcatagtct ccatcatcct 180 atgttctact ttttggccat tctctcctct gttgacatgg gcctatccac atccaccatc 240 cccaagatgg ttggcatttt ctggttcaac ttgagagaaa tcacttttga gggctgcctc 300 attcagatgt tcttcatcca cttatgtact ggtatggagt cagctgtgct cgtggccatc 360 gcctatgatc actacgtggc tatctttaac cctcttcggt acacactggt gttgacaaac 420 aatgtggtat ccattatagc attgatcatc cttctgagat ccataccctt tgttctgctc 480 atcttaagat tacctttctg tggacaccaa atcatctccc acacttactg tgagcacatg 540 ggcattgccc gcctgtcctg tgccagcata aaggtaaaca tcatctatgg cttatgtgct 600

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atctctattt tggtgtttga catcatagcc attatcatct cctatgtcta taccctccat 660 gctgtctttt gtctcccttc cagggatgtc caaatgaagg cactcagcac ttgtagctcc 720 catgtgtatg taatgttggc tttctacact ccagcatttt tctccttcat gacccaccga 780 tttggccaaa atgttcctca atacatccac attcttcttg ccaactttta tgtcatcatc 840 ccacctgctc tcaaccctgt aatttatgag gtcagaacta ggcagataag agaaaaagta 900 actagaattt taacatataa a 921

<210> 1342 <211> 307 <212> PRT <213> Canis familiaris <400> 1342

Met Val Pro Ser Asn Asp Thr Gln Phe His Pro Asn Phe Phe Leu Leu 1 5 10 15 Leu Gly Ile Pro Gly Leu Glu Asp Met His Met Trp Ile Gly Phe Pro 20 25 30 Phe Cys Val Ile Tyr Leu Thr Ala Leu Leu Gly Asn Leu Thr Ile Leu 35 40 45 Phe Val Ile Gln Thr Asp His Ser Leu His His Pro Met Phe Tyr Phe 50 55 60 Leu Ala Ile Leu Ser Ser Val Asp Met Gly Leu Ser Thr Ser Thr Ile 65 70 75 80 Pro Lys Met Val Gly Ile Phe Trp Phe Asn Leu Arg Glu Ile Thr Phe 85 90 95 Glu Gly Cys Leu Ile Gln Met Phe Phe Ile His Leu Cys Thr Gly Met 100 105 110 Glu Ser Ala Val Leu Val Ala Ile Ala Tyr Asp His Tyr Val Ala Ile 115 120 125

Page 1508

Phe Asn 130 Pro Leu Arg Tyr Thr 135 069269_0225_SL.TXT Leu Val Leu Thr Asn Asn 140 Val Val Ser Ile Ile Ala Leu Ile Ile Leu Leu Arg Ser Ile Pro Phe Val Leu Leu 145 150 155 160 Ile Leu Arg Leu Pro Phe Cys Gly His Gln Ile Ile Ser His Thr Tyr 165 170 175 Cys Glu His Met Gly Ile Ala Arg Leu Ser Cys Ala Ser Ile Lys Val 180 185 190 Asn Ile Ile Tyr Gly Leu Cys Ala Ile Ser Ile Leu Val Phe Asp Ile 195 200 205 Ile Ala Ile Ile Ile Ser Tyr Val Tyr Thr Leu His Ala Val Phe Cys 210 215 220 Leu Pro Ser Arg Asp Val Gln Met Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Val Tyr Val Met Leu Ala Phe Tyr Thr Pro Ala Phe Phe Ser Phe 245 250 255 Met Thr His Arg Phe Gly Gln Asn Val Pro Gln Tyr Ile His Ile Leu 260 265 270 Leu Ala Asn Phe Tyr Val Ile Ile Pro Pro Ala Leu Asn Pro Val Ile 275 280 285 Tyr Glu Val Arg Thr Arg Gln Ile Arg Glu Lys Val Thr Arg Ile Leu 290 295 300 Thr Tyr Lys

<210> 1343 <211> 960 <212> DNA <213> Canis familiaris

305

Page 1509

069269_0225_SL.TXT <400> 1343

atggcaaccc tcaaccacac tattatcagc cactcattct tcattctgct gggcatccct 60 ggcctggaag accagcacac atggatttct cttcctttct ttatttccta cctggttgct 120 gtccttggga atatcctcct tgtcttcatc atcatcactg aacgcagtct ccatgaacct 180 atgtacttct tcctctgcat gctagctgtg gccgacctca tcctgtccac taccactgtg 240 cccaaagcac tggccatatt ctggttccat gcaggggaga tctctcttga tggctgtgtt 300 actcaaatct ttttcatcca tgccacattc attgctgaat cagggattct gctggccatg 360 gcatttgacc gctatgtggc catctgtgac ccattgcgct atactatggt gctcagtcat 420 acagtaatca taagggttgg cttggctgtg gttctgagaa gcttctctgt gatactccca 480 gatgtgttcc tggtgaagag actgtctttc tgccatagca atgtgctacc acatacctac 540 tgcgagcaca tggctgttgc caagtttgct tgtgctgata ttcgtgtcaa tgtctggtac 600 ggcttgtctg ttctcctctc tactgtagtg gtagatgcct tgctcatctt ggtttcctac 660 accctcatcc tcaatgcagt cttccacctc ccttcccgag aagcccggca aaaggccctg 720 ggcacctgtg gctgccacct tggggtcatt tccatgttct acttgcctgg catttttaca 780 ataattaccc agcggtttgg gcaacatgtt cccctccaca ctcacattct gctggccaat 840 atctgcatgt tagctcctcc catgctgaac cctatcattt atggggtcaa gaccaaacag 900 attcgagagc gtgtggtcag tacttttcac agtggaacca tgctgagtct gtgtgactga 960

<210> 1344 <211> 319 <212> PRT <213> Canis familiaris <400> 1344

Met 1 Ala Thr Leu Asn His Thr Ile Ile Ser His Ser Phe Phe Ile Leu 5 10 15 Leu Gly Ile Pro Gly Leu Glu Asp Gln His Thr Trp Ile Ser Leu Pro 20 25 30 Phe Phe Ile Ser Tyr Leu Val Ala Val Leu Gly Asn Ile Leu Leu Val 35 40 45

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Phe Ile 50 Ile Ile Thr Glu Arg Ser 55 Leu His Glu Pro Met Tyr Phe 60 Phe Leu Cys Met Leu Ala Val Ala Asp Leu Ile Leu Ser Thr Thr Thr Val 65 70 75 80 Pro Lys Ala Leu Ala Ile Phe Trp Phe His Ala Gly Glu Ile Ser Leu 85 90 95 Asp Gly Cys Val Thr Gln Ile Phe Phe Ile His Ala Thr Phe Ile Ala 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg Tyr Thr Met Val Leu Ser His Thr Val Ile Ile 130 135 140 Arg Val Gly Leu Ala Val Val Leu Arg Ser Phe Ser Val Ile Leu Pro 145 150 155 160 Asp Val Phe Leu Val Lys Arg Leu Ser Phe Cys His Ser Asn Val Leu 165 170 175 Pro His Thr Tyr Cys Glu His Met Ala Val Ala Lys Phe Ala Cys Ala 180 185 190 Asp Ile Arg Val Asn Val Trp Tyr Gly Leu Ser Val Leu Leu Ser Thr 195 200 205 Val Val Val Asp Ala Leu Leu Ile Leu Val Ser Tyr Thr Leu Ile Leu 210 215 220 Asn Ala Val Phe His Leu Pro Ser Arg Glu Ala Arg Gln Lys Ala Leu 225 230 235 240 Gly Thr Cys Gly Cys His Leu Gly Val Ile Ser Met Phe Tyr Leu Pro 245 250 255

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Gly Ile Phe Thr Ile Ile Thr Gln Arg 265 Phe Gly Gln His Val 270 Pro Leu 260 His Thr His Ile Leu Leu Ala Asn Ile Cys Met Leu Ala Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Arg 290 295 300 Val Val Ser Thr Phe His Ser Gly Thr Met Leu Ser Leu Cys Asp 305 310 315

<210> 1345 <211> 939 <212> DNA <213> Canis familiaris <400> 1345

atgtcttctg tcaatgacag tgcctcatat ccctctgcct tccttctgtt gggtatacct 60 ggtttggaag ctttccatat ctggattgct ttccctttct ttgttgttta tctgatagca 120 cttgtgggga atgtcacaat cctgtttgtg attaagactg atcagagtct tcatcaaccc 180 atgttctatt ttctggctct cctctccttt attgacctag gcctctccac ttctaccatt 240 cccaagatgc tagctatatt ctggctcaac ttcagggaga taagatttga aggctgcctc 300 atccagatgt tctttatcca tacctatact ggtatggaat ctgtcgtact gctggccatg 360 gcaattgacc gctttgttgc tatctgttat ccactgagat acaccactat tctcaccaac 420 agagtggtag ccatcatggc ctcctttgta gtggggaggc cagtcctcct tgtcatcccc 480 ttctgccctc ttctcaaacg attgcccttt tgtggacact acattattcc tcacacttac 540 tgtgaacaca tgggaatcgc ccgtcttgcc tgtgctaata taagggtcaa catcatctat 600 ggtttattta ccattgctgc cctgattttt gacttgatcc ttattgccct ttcctatgtt 660 cagatcctac gagctgtttt ctgtcttcct tcgagggatg ccagactcaa agcacttagt 720 acatgtggtt cacatgtctg tgtcatccta gccttctaca caccagcatt tttctctttt 780 atgacacacc gatttggcag aaatattcct cgctacattc acatcctctt ggccaatctg 840 tacgtggttg ttcccccttg tttaaaccca gtcatttatg gggtcaggac aaagcaaatt 900

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069269_0225_SL.TXT cgggaccgag ttgtgaaaat atttgtaaag aaagagtga

939 <210> 1346 <211> 312 <212> PRT <213> Canis familiaris

<400> 1346 Met 1 Ser Ser Val Asn 5 Asp Ser Ala Ser Tyr Pro Ser Ala Phe Leu Leu 10 15 Leu Gly Ile Pro Gly Leu Glu Ala Phe His Ile Trp Ile Ala Phe Pro 20 25 30 Phe Phe Val Val Tyr Leu Ile Ala Leu Val Gly Asn Val Thr Ile Leu 35 40 45 Phe Val Ile Lys Thr Asp Gln Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Leu Leu Ser Phe Ile Asp Leu Gly Leu Ser Thr Ser Thr Ile 65 70 75 80 Pro Lys Met Leu Ala Ile Phe Trp Leu Asn Phe Arg Glu Ile Arg Phe 85 90 95 Glu Gly Cys Leu Ile Gln Met Phe Phe Ile His Thr Tyr Thr Gly Met 100 105 110 Glu Ser Val Val Leu Leu Ala Met Ala Ile Asp Arg Phe Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg Tyr Thr Thr Ile Leu Thr Asn Arg Val Val Ala 130 135 140 Ile Met Ala Ser Phe Val Val Gly Arg Pro Val Leu Leu Val Ile Pro 145 150 155 160 Phe Cys Pro Leu Leu Lys Arg Leu Pro Phe Cys Gly His Tyr Ile Ile 165 170 175

Page 1513

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Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala 180 185 190 Asn Ile Arg Val Asn Ile Ile Tyr Gly Leu Phe Thr Ile Ala Ala Leu 195 200 205 Ile Phe Asp Leu Ile Leu Ile Ala Leu Ser Tyr Val Gln Ile Leu Arg 210 215 220 Ala Val Phe Cys Leu Pro Ser Arg Asp Ala Arg Leu Lys Ala Leu Ser 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Ile Leu Ala Phe Tyr Thr Pro Ala 245 250 255 Phe Phe Ser Phe Met Thr His Arg Phe Gly Arg Asn Ile Pro Arg Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Cys Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Asp Arg Val 290 295 300 Val Lys Ile Phe Val Lys Lys Glu

305 310 <210> 1347 <211> 948 <212> DNA <213> Canis familiaris <400> 1347 atggttgact ttaactccac tacattcacc aatcctagta ccttcttcct gatgggcata cccggtctag aagacttgca catttggata tccatccctt tttgctcaat gtatattgtt gctctcctag gaaacatatt catccttttc atcatcaaaa ctgagactgc cctccatgaa cccatgttct attttctttc catgttagcc atcacagacc tcaccttgtc aacctccact

120

180

240

Page 1514

069269_0225_SL.TXT

cttcccaaga tgttgggtat attctggttc agtgatcatg aaatcagctt ccatgcctgc 300 ctcactcaga tgtttttcat ccatgctttt tctggggtgg agtcagggct tcttgtggcc 360 atggcacttg accggtatgt ggcaatctgc aacccactga gacactcatc cattcttaca 420 aattctgtgg tggctcatgt tggcatggtg gcacttctac gtggattagt actaatgaca 480 ccacatccct tcctggtgag gagatggcca tattgccagt ccaatgtagt tccccacaca 540 tactgtgagc acatggctgt ggtgaaattg gcttgtgctg acatttccat caatagtctt 600 tatagtttgg ctgtcatcat cttaattgtt gggactgatg tgacatgtat ctctctgtcc 660 tatgtacaaa tacttcgtac tgtatttaat ctcccttcta atgatgccag gttgaaaact 720 ctcagcactt gtgggtctca tgtatgtgtc atcctcacct tctacatccc tgctcttttc 780 tccttcctca cccaccgttt tagtaagcat ataccactgc acacccacac cctgctggcc 840 aacatgtact tgttggtacc tcctatgctg aaccctatca tctatggagt aaggaccaga 900 cacatccgag aatgtgttct acaattattt atgactaaaa tcaactga 948 <210> 1348 <211> 315 <212> PRT <213> Canis familiaris <400> 1348 Met Val Asp Phe Asn Ser Thr Thr Phe Thr Asn Pro Ser Thr Phe Phe 1 5 10 15 Leu Met Gly Ile Pro Gly Leu Glu Asp Leu His Ile Trp Ile Ser Ile 20 25 30 Pro Phe Cys Ser Met Tyr Ile Val Ala Leu Leu Gly Asn Ile Phe Ile 35 40 45 Leu Phe Ile Ile Lys Thr Glu Thr Ala Leu His Glu Pro Met Phe Tyr 50 55 60 Phe Leu Ser Met Leu Ala Ile Thr Asp Leu Thr Leu Ser Thr Ser Thr 65 70 75 80 Leu Pro Lys Met Leu Gly Ile Phe Trp Phe Ser Asp His Glu Ile Ser

Page 1515

069269_0225_SL.TXT

85 90 95

Phe His Ala Cys 100 Leu Thr Gln Met Phe Phe Ile His Ala Phe Ser Gly 105 110 Val Glu Ser Gly Leu Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala 115 120 125 Ile Cys Asn Pro Leu Arg His Ser Ser Ile Leu Thr Asn Ser Val Val 130 135 140 Ala His Val Gly Met Val Ala Leu Leu Arg Gly Leu Val Leu Met Thr 145 150 155 160 Pro His Pro Phe Leu Val Arg Arg Trp Pro Tyr Cys Gln Ser Asn Val 165 170 175 Val Pro His Thr Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys 180 185 190 Ala Asp Ile Ser Ile Asn Ser Leu Tyr Ser Leu Ala Val Ile Ile Leu 195 200 205 Ile Val Gly Thr Asp Val Thr Cys Ile Ser Leu Ser Tyr Val Gln Ile 210 215 220 Leu Arg Thr Val Phe Asn Leu Pro Ser Asn Asp Ala Arg Leu Lys Thr 225 230 235 240 Leu Ser Thr Cys Gly Ser His Val Cys Val Ile Leu Thr Phe Tyr Ile 245 250 255 Pro Ala Leu Phe Ser Phe Leu Thr His Arg Phe Ser Lys His Ile Pro 260 265 270 Leu His Thr His Thr Leu Leu Ala Asn Met Tyr Leu Leu Val Pro Pro 275 280 285 Met Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Arg His Ile Arg Glu

Page 1516

069269_0225_SL.TXT 290 295 300

Cys Val Leu Gln Leu Phe Met Thr Lys Ile Asn 305 310 315

<210> 1349 <211> 957 <212> DNA <213> Canis familiaris <400> 1349

atggaatatc tactgttaaa ttacaacagg accagtcttc gccctaccac cttcctacta 60 cttggcattc caggattgga ggctgtccac acatggattt ctgtcccttt ttgcctcgtc 120 tacttagtat cactgatggg aaatattgct cttctattaa ttgtcaagac agaccacaaa 180 ctgcatgaac ctatgtacct ctttctatgc atgttgtcag tagctgattt gatgcttact 240 tcttctacac ttcccaagat actcagcctc ttctggttca attacagaga gatctacttt 300 gaagcctgcc tccttcaaat gtacctcatt cattctttgt ctactatgga atctggattt 360 attttggcca tggcttttga ccgctacata gccatctgtc acccattaag acattccact 420 atcctaacac ctgcagtgat tgtaggtttg ggtttgggca ttgttttcag aggagctata 480 ctcctcagtc cacacccctt tttactgcgg tggctttcct attgcagaac taatgtcatc 540 tcccatacct actgtgagtt tatggcccta ataaaactgg tttgcactga gaccaagatt 600 cgtagagcct acagcctaat tgtggcattc cttacagggg ggttggattt catattgatc 660 atctgttcct atgtccttat tcttttcact gtctttaatc tcccatccaa agctgcccgc 720 ctcaagacct taagtacatg tgtctcccat gtatgggtca tcttagtgtt ttatacacca 780 gccttcttct cttttctcac tcataggttt ggtcaccaca ttgctccaca tattcatatt 840 tttgtagcca atatatatct tcttattcca cctatgatga accctattat ttatggtgtg 900 aagacaaaaa gaatcaggga gagatttttt aaattcttaa caatcaaatg tgtttga 957

<210> 1350 <211> 318 <212> PRT <213> Canis familiaris <400> 1350

Page 1517

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Met 1 Glu Tyr Leu Leu 5 Leu Asn Tyr Asn Arg Thr Ser Leu Arg Pro Thr 10 15 Thr Phe Leu Leu Leu Gly Ile Pro Gly Leu Glu Ala Val His Thr Trp 20 25 30 Ile Ser Val Pro Phe Cys Leu Val Tyr Leu Val Ser Leu Met Gly Asn 35 40 45 Ile Ala Leu Leu Leu Ile Val Lys Thr Asp His Lys Leu His Glu Pro 50 55 60 Met Tyr Leu Phe Leu Cys Met Leu Ser Val Ala Asp Leu Met Leu Thr 65 70 75 80 Ser Ser Thr Leu Pro Lys Ile Leu Ser Leu Phe Trp Phe Asn Tyr Arg 85 90 95 Glu Ile Tyr Phe Glu Ala Cys Leu Leu Gln Met Tyr Leu Ile His Ser 100 105 110 Leu Ser Thr Met Glu Ser Gly Phe Ile Leu Ala Met Ala Phe Asp Arg 115 120 125 Tyr Ile Ala Ile Cys His Pro Leu Arg His Ser Thr Ile Leu Thr Pro 130 135 140 Ala Val Ile Val Gly Leu Gly Leu Gly Ile Val Phe Arg Gly Ala Ile 145 150 155 160 Leu Leu Ser Pro His Pro Phe Leu Leu Arg Trp Leu Ser Tyr Cys Arg 165 170 175 Thr Asn Val Ile Ser His Thr Tyr Cys Glu Phe Met Ala Leu Ile Lys 180 185 190 Leu Val Cys Thr Glu Thr Lys Ile Arg Arg Ala Tyr Ser Leu Ile Val 195 200 205

Page 1518

Ala Phe 210 Leu Thr Gly Gly Leu 215 069269_0225_SL.TXT Asp Phe Ile Leu Ile Ile 220 Cys Ser Tyr Val Leu Ile Leu Phe Thr Val Phe Asn Leu Pro Ser Lys Ala Ala Arg 225 230 235 240 Leu Lys Thr Leu Ser Thr Cys Val Ser His Val Trp Val Ile Leu Val 245 250 255 Phe Tyr Thr Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His 260 265 270 His Ile Ala Pro His Ile His Ile Phe Val Ala Asn Ile Tyr Leu Leu 275 280 285 Ile Pro Pro Met Met Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Arg 290 295 300 Ile Arg Glu Arg Phe Phe Lys Phe Leu Thr Ile Lys Cys Val 305 310 315

<210> 1351 <211> 753 <212> DNA <213> Canis familiaris <400> 1351 atgcctcctt tcaacacctc ttctgtcacc ttcttattga tgagcatccc aggactagag 60 gacctgcata tctggattgg gatccccttc tgctccattt acatggtggc tgtggtgggg 120 aacgagacca tactggccgt ggtgagagca gagtgaagtc tccatgagcc tatgttcttc 180 tttctcagca tgctctccat cactgacctg gtcttctcct catccacgct tccctgcatg 240 ctctgtgtct tttggcttgg agcccatgac attgcctttg atgttttcct ggctcaaatg 300 ctttttattc acagttttac tgctatggaa tcgggctttt tcctggccat ggcctttgac 360 tgtcatgtgg ttatttgtca tccactgtgc cataccacca ttctcaccca tgctcacatc 420 accataatgg gcattattgt ggtgattcga ggtgtagcct tcttttctcc acatcccatc 480 ctgctcaaac agctgcctta ctgcagaaca cgaatcattg cccacactta ctatgagttc 540

Page 1519

069269_0225_SL.TXT atggctatag tgaagctggt gtgtgtggac ataggggcca ccaagagtta tagcctcagt atggcttcta tcattggctc atctgatgcc attctcattg ctatatccta tgccttcatc ctccactctg tgttcagcct gacatcccgg gaagctggct ttaaggcttt gggcacatgt gggtcacatg tctgtgttat tcctgttcta ttc

600

660

720

753 <210> 1352 <211> 194 <212> PRT <213> Canis familiaris <400> 1352

Met Phe 1 Phe Phe Leu 5 Ser Met Leu Ser Ile Thr Asp Leu Val Phe Ser 10 15 Ser Ser Thr Leu Pro Cys Met Leu Cys Val Phe Trp Leu Gly Ala His 20 25 30 Asp Ile Ala Phe Asp Val Phe Leu Ala Gln Met Leu Phe Ile His Ser 35 40 45 Phe Thr Ala Met Glu Ser Gly Phe Phe Leu Ala Met Ala Phe Asp Cys 50 55 60 His Val Val Ile Cys His Pro Leu Cys His Thr Thr Ile Leu Thr His 65 70 75 80 Ala His Ile Thr Ile Met Gly Ile Ile Val Val Ile Arg Gly Val Ala 85 90 95 Phe Phe Ser Pro His Pro Ile Leu Leu Lys Gln Leu Pro Tyr Cys Arg 100 105 110 Thr Arg Ile Ile Ala His Thr Tyr Tyr Glu Phe Met Ala Ile Val Lys 115 120 125 Leu Val Cys Val Asp Ile Gly Ala Thr Lys Ser Tyr Ser Leu Ser Met 130 135 140 Ala Ser Ile Ile Gly Ser Ser Asp Ala Ile Leu Ile Ala Ile Ser Tyr

Page 1520

06926 9_02 25_S L.TX T 145 150 155 160 Ala Phe Ile Leu His Ser Val Phe Ser Leu Thr Ser Arg Glu Ala Gly 165 170 175 Phe Lys Ala Leu Gly Thr Cys Gly Ser His Val Cys Val Ile Pro Val 180 185 190

Leu Phe <210> 1353 <211> 936 <212> DNA <213> Canis familiaris <400> 1353

atgacccatc aaaatacaac catgtttcat ccacccacat tttttctttt aggcattcca 60 gggcttgcaa ctgcccatgc ctggatttca ttgcccttct gttgtattta ctttattgct 120 ctcataggca atgtcacaat cttgatagtc atatggacag aaagaaccct ccgggatcca 180 atgttcttct tccttgtcat tctatcagcc atagacctgg ccctctccac aacctcagta 240 ccacgaatgt tgggtatctt ttggtttaat gctcatgaaa ttggctttgg agcttgcgtg 300 gcccagatgt ttctgataca caccttcaca ggaatggagt ctgctgttct gctggctatg 360 gcctttgacc gctatgttgc tatctgcgtc cccctccact acacaaccat cctgacagtc 420 cgagtgctgt caggaattgg agtgggtgtt gtcctgagta cagttgtgct cacattgccc 480 atgatctatc taatctaccg tctacccttc tgcaatgccc acattattgc ccacacctac 540 tgtgagcaca tgggcattgc caagttggct tgtgccagca ttcaaatcaa tgctatctat 600 ggtctctttg ttgcttcttt cctcgttctt gtcctggtac tggttggaat ctcctatggc 660 tacattctgt gtgccgtatt ccgcctcaaa tcacaagagg cccgtcacaa gacactgagc 720 acttgtacct ctcatgctgc agtcatgttt gttttctata caccctctct cttctccttc 780 cttactcacc gatttggccg aaaaatatcc ccttatatcc acattcttgt tgccaatatc 840 tatgtggtcc ttccaccagc tctcaatcct atcatctatg gagtaaggac taagcaaatc 900 agagagtgtg tgatccgagt atttactggc aagtaa 936

Page 1521

069269_0225_SL.TXT <210> 1354 <211> 311 <212> PRT <213> Canis familiaris

<400> 1354 Met 1 Thr His Gln Asn 5 Thr Thr Met Phe His Pro Pro Thr Phe Phe Leu 10 15 Leu Gly Ile Pro Gly Leu Ala Thr Ala His Ala Trp Ile Ser Leu Pro 20 25 30 Phe Cys Cys Ile Tyr Phe Ile Ala Leu Ile Gly Asn Val Thr Ile Leu 35 40 45 Ile Val Ile Trp Thr Glu Arg Thr Leu Arg Asp Pro Met Phe Phe Phe 50 55 60 Leu Val Ile Leu Ser Ala Ile Asp Leu Ala Leu Ser Thr Thr Ser Val 65 70 75 80 Pro Arg Met Leu Gly Ile Phe Trp Phe Asn Ala His Glu Ile Gly Phe 85 90 95 Gly Ala Cys Val Ala Gln Met Phe Leu Ile His Thr Phe Thr Gly Met 100 105 110 Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Val Pro Leu His Tyr Thr Thr Ile Leu Thr Val Arg Val Leu Ser 130 135 140 Gly Ile Gly Val Gly Val Val Leu Ser Thr Val Val Leu Thr Leu Pro 145 150 155 160 Met Ile Tyr Leu Ile Tyr Arg Leu Pro Phe Cys Asn Ala His Ile Ile 165 170 175

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Ala His Thr Tyr 180 Cys Glu His Met Gly 185 Ile Ala Lys Leu Ala 190 Cys Ala Ser Ile Gln Ile Asn Ala Ile Tyr Gly Leu Phe Val Ala Ser Phe Leu 195 200 205 Val Leu Val Leu Val Leu Val Gly Ile Ser Tyr Gly Tyr Ile Leu Cys 210 215 220 Ala Val Phe Arg Leu Lys Ser Gln Glu Ala Arg His Lys Thr Leu Ser 225 230 235 240 Thr Cys Thr Ser His Ala Ala Val Met Phe Val Phe Tyr Thr Pro Ser 245 250 255 Leu Phe Ser Phe Leu Thr His Arg Phe Gly Arg Lys Ile Ser Pro Tyr 260 265 270 Ile His Ile Leu Val Ala Asn Ile Tyr Val Val Leu Pro Pro Ala Leu 275 280 285 Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Cys Val 290 295 300 Ile Arg Val Phe Thr Gly Lys 305 310

<210> 1355 <211> 951 <212> DNA <213> Canis familiaris <400> 1355 atggcatcta tcaatacatc atatttgaac cccgaaacag taatcttgat tggaattcct ggactagaac atgtgcagtt ttggattggg tttcctttcc ttgctgtgtg cctagtggct cttttgggaa atatcgtttt actaatcatc attcctacag aacacagcct gcatcagccc atgtacatct tcctggcagt gctggcagcc accgacatag gactctgtgc agccattgct cccaagatgt tggccatctt ctggttcaga tcttgctcca tggcctttga cacctgccta

120

180

240

300

Page 1523

0 69269_0225_S L.TXT acccagttgt tcttcattca tgccttgcag tgcatggagt ctggcattct gttggccatg 360 gcttttgacc gctatgttgc catctgtgat ccactgagac acacatccat cctcacatct 420 tccattctgt gtcgcatgat agtaatagtg gcaattcgag ctacagtgct ggttggtctg 480 ttacccattc taatcaaaag attgcatgtt tttcattcca ttgtgattgc tcactcttac 540 tgtgagcaca tggctgtagt caagctagct gcagaagatg cccaagtcaa taaagcatgt 600 ggtctttttg tgggttttac catactggga tttgacatga tttttatcct catttcctat 660 atccttattt tccaggcagt ttttcatcta caccaaaagg aggcacggct caaagcattt 720 aacacatgta cagctcatat ttttgttttt cttgagtttt atattcttgc cttcttctcc 780 ttcttcagcc accgttttgg acatgttgct ccccctaccc acattcttct gtctactatc 840 tacctccttg tgccacctgc actcaaccct attgtctatg gtgtaaaaaa caaggtaatt 900 cgtaagcgtg tggcacagat ttttcttctg <210> 1356 <211> 316 <212> PRT <213> Canis familiaris <400> 1356 agtcatatat cccaccagtg a 951 Met Ala Ser Ile Asn Thr Ser Tyr 1 5 Leu Asn Pro 10 Glu Thr Val Ile Leu 15 Ile Gly Ile Pro Gly Leu Glu His 20 Val Gln Phe 25 Trp Ile Gly Phe Pro 30 Phe Leu Ala Val Cys Leu Val Ala 35 40 Leu Leu Gly Asn Ile Val Leu Leu 45 Ile Ile Ile Pro Thr Glu His Ser 50 55 Leu His Gln Pro Met Tyr Ile Phe 60 Leu Ala Val Leu Ala Ala Thr Asp 65 70 Ile Gly Leu 75 Cys Ala Ala Ile Ala 80 Pro Lys Met Leu Ala Ile Phe Trp 85 Phe Arg Ser 90 Cys Ser Met Ala Phe 95

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Asp Thr Cys Leu Thr Gln Leu Phe Phe Ile His Ala Leu Gln Cys Met 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Thr Ser Ile Leu Thr Ser Ser Ile Leu Cys 130 135 140 Arg Met Ile Val Ile Val Ala Ile Arg Ala Thr Val Leu Val Gly Leu 145 150 155 160 Leu Pro Ile Leu Ile Lys Arg Leu His Val Phe His Ser Ile Val Ile 165 170 175 Ala His Ser Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Ala Glu 180 185 190 Asp Ala Gln Val Asn Lys Ala Cys Gly Leu Phe Val Gly Phe Thr Ile 195 200 205 Leu Gly Phe Asp Met Ile Phe Ile Leu Ile Ser Tyr Ile Leu Ile Phe 210 215 220 Gln Ala Val Phe His Leu His Gln Lys Glu Ala Arg Leu Lys Ala Phe 225 230 235 240 Asn Thr Cys Thr Ala His Ile Phe Val Phe Leu Glu Phe Tyr Ile Leu 245 250 255 Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly His Val Ala Pro Pro 260 265 270 Thr His Ile Leu Leu Ser Thr Ile Tyr Leu Leu Val Pro Pro Ala Leu 275 280 285 Asn Pro Ile Val Tyr Gly Val Lys Asn Lys Val Ile Arg Lys Arg Val 290 295 300

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Ala Gln Ile Phe Leu Leu Ser His Ile Ser His Gln 305 310 315 <210> 1357 <211> 948 <212> DNA <213> Canis familiaris <400> 1357

atgggatcta taaacatgtc atatttgaac ccaaagacag tgaccctgat tgggatccct 60 ggactagagc atgtgcagtt ttggattgga tttcctttcc ttggagtgtg cctggtggct 120 ctgctgggga acatcttctt gttaatcatc atccctatag aacgttgtct tcaccaaccc 180 atgtacatct tcctggcagt tttggcagcc actgacctag gcctctgtgt agccattgct 240 cccaagatgt tggccatctt ctggtttggc tcttactcca tggcttttga tgcttgcctc 300 acccagctct tcttcatcca tgccttgcag ggcatggaat ctggtatcct gttggccatg 360 gcctttgacc gctatgttgc catctgtgat cccttgagac acacatccat tcttacacct 420 ctctttctag ttcaaatggt actgatggtg gccatccggg caacggtgct agttggaatt 480 ttacccattc tacttaaacg cttgcaactt ttccattctg tggttattgt tcattcctac 540 tgtgaacaca tggctgtggt caagctggtt gcagaagatg tccatattaa caaatcatat 600 gggctctttg tagcctttgc aattctaggt tttgatatga tctttgtctt catctcctac 660 attttgattt ttcaggctgt ttttcgtctt ccccagaaag aggcaagact caaagcattc 720 aatacttgta ctgcccatat tgctgtcttc ctggagtttt atatccttgc ctttttttcc 780 ttcttcagcc accgttttgg acatgtatca ccctatgttc atattctctt gtctaccatc 840 tatctgcttg tgccgcctgc ccttaacccc attatctatg gtgtgaagac caaggagatc 900 cgcatgcggg ttgctcagat ttgtattctg aggtctgaca atgagtag 948

<210> 1358 <211> 315 <212> PRT <213> Canis familiaris <400> 1358

Met Gly Ser Ile Asn Met Ser Tyr Leu Asn Pro Lys Thr Val Thr Leu 1 5 10 15

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Ile Gly Ile Pro 20 Gly Leu Glu His Val Gln Phe Trp Ile Gly Phe Pro 25 30 Phe Leu Gly Val Cys Leu Val Ala Leu Leu Gly Asn Ile Phe Leu Leu 35 40 45 Ile Ile Ile Pro Ile Glu Arg Cys Leu His Gln Pro Met Tyr Ile Phe 50 55 60 Leu Ala Val Leu Ala Ala Thr Asp Leu Gly Leu Cys Val Ala Ile Ala 65 70 75 80 Pro Lys Met Leu Ala Ile Phe Trp Phe Gly Ser Tyr Ser Met Ala Phe 85 90 95 Asp Ala Cys Leu Thr Gln Leu Phe Phe Ile His Ala Leu Gln Gly Met 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Thr Ser Ile Leu Thr Pro Leu Phe Leu Val 130 135 140 Gln Met Val Leu Met Val Ala Ile Arg Ala Thr Val Leu Val Gly Ile 145 150 155 160 Leu Pro Ile Leu Leu Lys Arg Leu Gln Leu Phe His Ser Val Val Ile 165 170 175 Val His Ser Tyr Cys Glu His Met Ala Val Val Lys Leu Val Ala Glu 180 185 190 Asp Val His Ile Asn Lys Ser Tyr Gly Leu Phe Val Ala Phe Ala Ile 195 200 205 Leu Gly Phe Asp Met Ile Phe Val Phe Ile Ser Tyr Ile Leu Ile Phe 210 215 220

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Gln 225 Ala Val Phe Arg Leu Pro Gln Lys Glu Ala Arg Leu Lys Ala Phe 230 235 240 Asn Thr Cys Thr Ala His Ile Ala Val Phe Leu Glu Phe Tyr Ile Leu 245 250 255 Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly His Val Ser Pro Tyr 260 265 270 Val His Ile Leu Leu Ser Thr Ile Tyr Leu Leu Val Pro Pro Ala Leu 275 280 285 Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Glu Ile Arg Met Arg Val 290 295 300 Ala Gln Ile Cys Ile Leu Arg Ser Asp Asn Glu 305 310 315

<210> 1359 <211> 945 <212> DNA <213> Canis familiaris <400> 1359 atgacctctt gcaacaactc cattcctcaa cctttgatat ttgttctggc tggaatccct 60 ggcctggaat cttcccatgg ctggttctct gtgccttttt tcttggtctt tgttgttaca 120 atttttggga ataccaccat cttatgcatc atccgagtag agaagagtct tcatgagccc 180 atgtttctcc tcctggccat gctatctgtt gttgacctgt ccctggtcag tgtcactgtg 240 ccccgcatgc tggatatctt ctggatgaat gccaaagaaa tcagcttcaa tgcctgcctc 300 acacaaatgt ttttcatccc ttccttttac gtcatggagt ctgggatcct cctagccatg 360 gcttttgaca gatttgtggc tatctggttt cctctgagat atacaaccat ccttgctaac 420 aaggtacttg tgaagatggc actgactgtc ctggcaaggg cagtggcagt gctgactcca 480 gcacccatcc tggcagaaag actggaaagg ttccaaaccc acatcatcgc ttactcctac 540 tgtgcctata tggctgtggt gaagatagcc tgtggagaca tctccaacca cattttctat 600

Page 1528

069269_0225_SL.TXT ggcctcatgg ttcttgtagc atccgtggga cttgatctat tttttatcat tctgtcatat 660 gggctgatcc ttcatgctgt ctttcagata ccctcttggg aggcacgggg caaagctctc 720 aatacatgtg gctcccacct ttgtgtcata gctctttttt attctcctgt tgtcttctct 780 gtcctggccc agattttagg ctaccatatg gctcctcatc tacaaattat cattgacaat 840 ctctacttcc tagtgcctcc catggtcaat cccttgattt atggggcccg aactaagcaa 900 atgcgggagc ggatgctgcg gatcttccac tgtcatagaa actga 945 <210> 1360 <211> 314 <212> PRT <213> Canis familiaris

<400> 1360 Asn Ser Ile Pro Gln Pro Leu Ile Phe Val Leu Met 1 Thr Ser Cys Asn 5 10 15 Ala Gly Ile Pro Gly Leu Glu Ser Ser His Gly Trp Phe Ser Val Pro 20 25 30 Phe Phe Leu Val Phe Val Val Thr Ile Phe Gly Asn Thr Thr Ile Leu 35 40 45 Cys Ile Ile Arg Val Glu Lys Ser Leu His Glu Pro Met Phe Leu Leu 50 55 60 Leu Ala Met Leu Ser Val Val Asp Leu Ser Leu Val Ser Val Thr Val 65 70 75 80 Pro Arg Met Leu Asp Ile Phe Trp Met Asn Ala Lys Glu Ile Ser Phe 85 90 95 Asn Ala Cys Leu Thr Gln Met Phe Phe Ile Pro Ser Phe Tyr Val Met 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125

Trp

Phe Pro Leu Arg

Tyr Thr Thr

Ile Leu Ala Asn

Lys Val Leu Val

Page 1529

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130 135 140 Lys Met Ala Leu Thr Val Leu Ala Arg Ala Val Ala Val Leu Thr Pro 145 150 155 160 Ala Pro Ile Leu Ala Glu Arg Leu Glu Arg Phe Gln Thr His Ile Ile 165 170 175 Ala Tyr Ser Tyr Cys Ala Tyr Met Ala Val Val Lys Ile Ala Cys Gly 180 185 190 Asp Ile Ser Asn His Ile Phe Tyr Gly Leu Met Val Leu Val Ala Ser 195 200 205 Val Gly Leu Asp Leu Phe Phe Ile Ile Leu Ser Tyr Gly Leu Ile Leu 210 215 220 His Ala Val Phe Gln Ile Pro Ser Trp Glu Ala Arg Gly Lys Ala Leu 225 230 235 240 Asn Thr Cys Gly Ser His Leu Cys Val Ile Ala Leu Phe Tyr Ser Pro 245 250 255 Val Val Phe Ser Val Leu Ala Gln Ile Leu Gly Tyr His Met Ala Pro 260 265 270 His Leu Gln Ile Ile Ile Asp Asn Leu Tyr Phe Leu Val Pro Pro Met 275 280 285 Val Asn Pro Leu Ile Tyr Gly Ala Arg Thr Lys Gln Met Arg Glu Arg 290 295 300 Met Leu Arg Ile Phe His Cys His Arg Asn

305 310 <210> 1361 <211> 945 <212> DNA <213> Canis familiaris

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<400> 1361 atgggactag ccaataaatc tcaaacatct ccagacacct tcttgctgat gggcatccca 60 ggactagagc acctgcatgt atggattggg atccccttct gctccatgta cgtggtggct 120 gtggtgggga atgtgaccat cctggctgtg gtgagggcag agcgaagtct ccatgagcct 180 atgttcttct ttctctgcat gctctccatc accgacctgg tcctctccac atccacgctg 240 ccccgcatgc tctgtctctt ctggcttgga gcccatgaca ttgcctttga tgcctgcctg 300 gctcaaatgt tcttcattca tagctttact gcgatggaat cgggcttttt cctagccatg 360 gcctttgacc gttatgtggc catttgtcat ccactgcgcc ataccacgat tctcacccat 420 gctcgcattg ccaaaatggg agcttctgtg gtactccggg gagtggcctt cttttcccca 480 catcccatcc tgctcaaaca gctgccctac tgcagaacac gaatcattgc ccacacctac 540 tgtgagttca tggctgtggt gaagctggcg tgtgtggaca caggagctac caaacgttac 600 agcctcagtg tggcctctgt cattggttcc tgtgatggct ttttcatcgc tgtctcttat 660 gtcctaatcc tccgtgcagt ctttcgcctt ccatcacggg aagcaagttt taaagctcta 720 ggcacctgtg gctcccatgt ctgtgtcatc cttgttttct actctacagc tgtctttacc 780 ttcctcactc accgctttgg ccacaatgtg gctccccaaa ttcatatctt tattgccaat 840 atgtacctcc tggtaccacc tttccttaat cccattgttt atggtattag gaccaaaaaa 900 attcgagacc atgtccttag ttctctaaag gtaaaagtca cttga 945

<210> 1362 <211> 314 <212> PRT <213> Canis familiaris <400> 1362

Met Gly Leu Ala Asn Lys Ser Gln Thr Ser Pro Asp Thr Phe Leu Leu 1 5 10 15 Met Gly Ile Pro Gly Leu Glu His Leu His Val Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ser Met Tyr Val Val Ala Val Val Gly Asn Val Thr Ile Leu

35 40 45

Page 1531

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Ala Val 50 Val Arg Ala Glu Arg Ser 55 Leu His Glu Pro Met Phe 60 Phe Phe Leu Cys Met Leu Ser Ile Thr Asp Leu Val Leu Ser Thr Ser Thr Leu 65 70 75 80 Pro Arg Met Leu Cys Leu Phe Trp Leu Gly Ala His Asp Ile Ala Phe 85 90 95 Asp Ala Cys Leu Ala Gln Met Phe Phe Ile His Ser Phe Thr Ala Met 100 105 110 Glu Ser Gly Phe Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg His Thr Thr Ile Leu Thr His Ala Arg Ile Ala 130 135 140 Lys Met Gly Ala Ser Val Val Leu Arg Gly Val Ala Phe Phe Ser Pro 145 150 155 160 His Pro Ile Leu Leu Lys Gln Leu Pro Tyr Cys Arg Thr Arg Ile Ile 165 170 175 Ala His Thr Tyr Cys Glu Phe Met Ala Val Val Lys Leu Ala Cys Val 180 185 190 Asp Thr Gly Ala Thr Lys Arg Tyr Ser Leu Ser Val Ala Ser Val Ile 195 200 205 Gly Ser Cys Asp Gly Phe Phe Ile Ala Val Ser Tyr Val Leu Ile Leu 210 215 220 Arg Ala Val Phe Arg Leu Pro Ser Arg Glu Ala Ser Phe Lys Ala Leu 225 230 235 240 Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Val Phe Tyr Ser Thr 245 250 255

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Ala Val Phe Thr Phe Leu Thr His Arg Phe 265 Gly His Asn Val 270 Ala Pro 260 Gln Ile His Ile Phe Ile Ala Asn Met Tyr Leu Leu Val Pro Pro Phe 275 280 285 Leu Asn Pro Ile Val Tyr Gly Ile Arg Thr Lys Lys Ile Arg Asp His 290 295 300 Val Leu Ser Ser Leu Lys Val Lys Val Thr 305 310

<210> 1363 <211> 945 <212> DNA <213> Canis familiaris <400> 1363

atgcctcctc tcaacacctc tcgtcccttt cctgtcacct tcttgctgat gggcatccca 60 ggactagagc acctgcatgt atggattggg atccccttct gctccatgta cgtggtggct 120 gtggtgggga atgtgaccat cctggctgtg gtgagggcag agcgaagtct ccatgagcct 180 atgttcttct ttctctgcat gctctccatc accgacctgg tcctctccac atccacgctg 240 ccccgcatgc tctgtctctt ctggcttgga gcccatgaca ttgccttcga tgcctgccta 300 gctcaaatgt tcttcattca tagctttact accatggaat cgggcttttt cctggccatg 360 gcctttgacc gttacgtggc catttgtcat ccactgcacc ataccacgat tctcacccat 420 gctcgcatca ccataatggg tattattgtg gtgattcggg gagtggcctt cttttcccca 480 catcccatcc tcctcaaaca gctgccctac tgcagaacac gaatcattgc ccacacctac 540 tgtgagttca tggctgtagt gaagctggca tgtgtagaca caggagccac cactcgttat 600 agcctcagtg tggcttctat cattggctcg tgtgatgcca ttctcactgt tgtatcctat 660 gccttcattc tccactctgt gttcagcctg ccatcccgag aagctggctt taaggctttg 720 ggcacatgtg gatcacatgt ctgtgttatt cttgtgttct attccacagc tggtttttcc 780 attttcactc accgttttgg gaagaatgtg cctgcacaca tccatatttt tattgcaaat 840 atgtaccttt tggtgccccc ttttctcaac cccattgtgt atggagtaag gaccaagaag 900

Page 1533

945

069269_0225_SL.TXT atacgggagc atgttcttag agtgctaaag gtcaatgttg cctga <210> 1364 <211> 314 <212> PRT <213> Canis familiaris <400> 1364

Met 1 Pro Pro Leu Asn 5 Thr Ser Arg Pro Phe Pro Val Thr Phe Leu Leu 10 15 Met Gly Ile Pro Gly Leu Glu His Leu His Val Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ser Met Tyr Val Val Ala Val Val Gly Asn Val Thr Ile Leu 35 40 45 Ala Val Val Arg Ala Glu Arg Ser Leu His Glu Pro Met Phe Phe Phe 50 55 60 Leu Cys Met Leu Ser Ile Thr Asp Leu Val Leu Ser Thr Ser Thr Leu 65 70 75 80 Pro Arg Met Leu Cys Leu Phe Trp Leu Gly Ala His Asp Ile Ala Phe 85 90 95 Asp Ala Cys Leu Ala Gln Met Phe Phe Ile His Ser Phe Thr Thr Met 100 105 110 Glu Ser Gly Phe Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu His His Thr Thr Ile Leu Thr His Ala Arg Ile Thr 130 135 140 Ile Met Gly Ile Ile Val Val Ile Arg Gly Val Ala Phe Phe Ser Pro 145 150 155 160 His Pro Ile Leu Leu Lys Gln Leu Pro Tyr Cys Arg Thr Arg Ile Ile 165 170 175

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Ala His Thr Tyr 180 Cys Glu Asp Thr Gly 195 Ala Thr Thr Gly Ser 210 Cys Asp Ala Ile His 225 Ser Val Phe Ser Leu 230 Gly Thr Cys Gly Ser 245 His Ala Gly Phe Ser 260 Ile Phe His Ile His 275 Ile Phe Ile Leu Asn 290 Pro Ile Val Tyr Val 305 Leu Arg Val Leu Lys 310

Phe Met Ala 185 Val Val Arg Tyr 200 Ser Leu Ser Leu 215 Thr Val Val Ser Pro Ser Arg Glu Ala 235 Val Cys Val Ile 250 Leu Thr His Arg 265 Phe Gly Ala Asn 280 Met Tyr Leu Gly 295 Val Arg Thr Lys Val Asn Val Ala

Lys Leu Ala 190 Cys Val Val Ala 205 Ser Ile Ile Tyr 220 Ala Phe Ile Leu Gly Phe Lys Ala Leu 240 Val Phe Tyr Ser 255 Thr Lys Asn Val 270 Pro Ala Leu Val 285 Pro Pro Phe Lys 300 Ile Arg Glu His

<210> 1365 <211> 954 <212> DNA <213> Canis familiaris <400> 1365 atgttctcct gcaacaccag ggcctggaag cctctcatca atcctgggta acagtatcat atgtattttt tcctatctat cccacgatga tgtggctctt cacttctggt cactctacgt ttgggtttcc atccctgtca ccttctcctg attcgtacag gttggcagcc tctgatctgg ctggctgaat gctcgtgagc ttctcctcac tggctttcca acctcacctg tgtggtttcc atccagcctt acatgaaccc gactcagtgc ctctaccttt ttccctttga tatctgtgca

120

180

240

300

Page 1535

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gcacaaatgt tcttcatcca tgccttcacc tatgtggaat ctggtgtgct actggccatg 360 gcctttgatc gttttgttgc catccgggaa cctctgcact atgccacaat tctgactcac 420 tcagctatgg ccagaatggg ggctgccatc cttgtgaggg ctgtcttgct caatctccca 480 ggacccatcc tcctgcgacg tctgcttttt ccccagatca gcgtactctc tcactgctac 540 tgcctgcact gtgaccttgt gggactggcc tgctcagaca cccagataaa cagcttggtt 600 ggcctagtct ccattctctt ctcactaggc cttgactcct tcctcattgt gctctcatat 660 gccctgatcc tacgaacagt ggtgagcatt gcatcacctg gggaaaggct caaggcactt 720 aacacgtgtg tctcacatct ctgcattgtt ctcatctttt atttgcccaa actagggcta 780 tctgtgttgc accgggtaga gaagcacaac taccctgctc tggcagtgct catggccaac 840 ctgcacttct tggtcccacc tttcatgaac cctattgttt actgcatcaa gtctaaacag 900 atacgtcagg gcctcctaaa gcgcttcaaa cggaagaggg ttgacgtctc ctag 954

<210> 1366 <211> 317 <212> PRT <213> Canis familiaris

<400> 1366 Asn Thr 5 Ser Thr Ser Gly His Ser Thr Phe Leu Leu Met Phe 1 Ser Cys 10 15 Thr Gly Phe Pro Gly Leu Glu Ala Ser His His Trp Val Ser Ile Pro 20 25 30 Val Asn Leu Thr Cys Val Val Ser Ile Leu Gly Asn Ser Ile Ile Leu 35 40 45 Leu Leu Ile Arg Thr Asp Pro Ala Leu His Glu Pro Met Tyr Phe Phe 50 55 60 Leu Ser Met Leu Ala Ala Ser Asp Leu Gly Leu Ser Ala Ser Thr Phe 65 70 75 80 Pro Thr Met Met Trp Leu Phe Trp Leu Asn Ala Arg Glu Leu Pro Phe 85 90 95

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Asp Ile Cys Ala 100 Ala Gln Met Phe Phe Ile His Ala Phe Thr Tyr Val 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Arg Glu Pro Leu His Tyr Ala Thr Ile Leu Thr His Ser Ala Met Ala 130 135 140 Arg Met Gly Ala Ala Ile Leu Val Arg Ala Val Leu Leu Asn Leu Pro 145 150 155 160 Gly Pro Ile Leu Leu Arg Arg Leu Leu Phe Pro Gln Ile Ser Val Leu 165 170 175 Ser His Cys Tyr Cys Leu His Cys Asp Leu Val Gly Leu Ala Cys Ser 180 185 190 Asp Thr Gln Ile Asn Ser Leu Val Gly Leu Val Ser Ile Leu Phe Ser 195 200 205 Leu Gly Leu Asp Ser Phe Leu Ile Val Leu Ser Tyr Ala Leu Ile Leu 210 215 220 Arg Thr Val Val Ser Ile Ala Ser Pro Gly Glu Arg Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Val Ser His Leu Cys Ile Val Leu Ile Phe Tyr Leu Pro 245 250 255 Lys Leu Gly Leu Ser Val Leu His Arg Val Glu Lys His Asn Tyr Pro 260 265 270 Ala Leu Ala Val Leu Met Ala Asn Leu His Phe Leu Val Pro Pro Phe 275 280 285 Met Asn Pro Ile Val Tyr Cys Ile Lys Ser Lys Gln Ile Arg Gln Gly 290 295 300

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Leu Leu Lys Arg Phe Lys Arg Lys Arg Val Asp Val Ser 305 310 315 <210> 1367 <211> 951 <212> DNA <213> Canis familiaris <400> 1367

atggcatcca ttaacatgtc atatctggac cccacaacag tgatgctaat tgggatccct 60 ggactagagc atgtgcaatt ttggattgga ttttccttct ttgtagtatg tgtggtggct 120 tttctgggaa acatcatttt actgatcatc attcctgcag aacgcagctt gcatcaaccc 180 atgtacatct tcctggcagt gctggcagcc actgacatag gactctgtgt agctattgct 240 cccaagatgt tggccatctt ctggtttggc tcccgctcca tggcttttga tgcttgctta 300 gcccagcttt tcttcatcca ttccttgcag ggcatggaat ctggcatcct gttggccatg 360 gcctttgacc gctatgttgc catctgtgat ccactgaggc acacatccat cctcactcct 420 ttcatcttgg ttactttggt gctggttgtg gcaattcggg caatggtgct cgttggcatt 480 ctacctgttt taatcaaaag actacacttt ttccattcca ttgtgattgc tcactcttac 540 tgtgagcaca tggctgtggt caagctagct gcagaagaca tccgagtcaa taaaacatgt 600 ggtctccttg taggttttac aatactgggg tttgacatga tttttattat tatttcttac 660 attcttattt tccaggctgt tttccgtcta catcaaaaag aggctcggct caaagcattt 720 aatacatgta cagctcacat ttttgttttc cttgaatttt atattcttgc cttcttttcc 780 ttcttcagcc accgttttgg acatgttgct ccccctaccc atattcttct gtctaccatc 840 tacctgcttg tgccacctgc actcaaccct atcgtctatg gtgtaaaaaa caaggtgatt 900 cgtagacgtg tggcacagat tttttttctg aattgtcaat cccggcagta a 951

<210> 1368 <211> 316 <212> PRT <213> Canis familiaris <400> 1368

Met Ala Ser Ile Asn Met Ser Tyr Leu Asp Pro Thr Thr Val Met Leu

Page 1538

0 6926 9_02 25_S L.TX T 1 5 10 15 Ile Gly Ile Pro Gly Leu Glu His Val Gln Phe Trp Ile Gly Phe Ser 20 25 30 Phe Phe Val Val Cys Val Val Ala Phe Leu Gly Asn Ile Ile Leu Leu 35 40 45 Ile Ile Ile Pro Ala Glu Arg Ser Leu His Gln Pro Met Tyr Ile Phe 50 55 60 Leu Ala Val Leu Ala Ala Thr Asp Ile Gly Leu Cys Val Ala Ile Ala 65 70 75 80 Pro Lys Met Leu Ala Ile Phe Trp Phe Gly Ser Arg Ser Met Ala Phe 85 90 95 Asp Ala Cys Leu Ala Gln Leu Phe Phe Ile His Ser Leu Gln Gly Met 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Thr Ser Ile Leu Thr Pro Phe Ile Leu Val 130 135 140 Thr Leu Val Leu Val Val Ala Ile Arg Ala Met Val Leu Val Gly Ile 145 150 155 160 Leu Pro Val Leu Ile Lys Arg Leu His Phe Phe His Ser Ile Val Ile 165 170 175 Ala His Ser Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Ala Glu 180 185 190 Asp Ile Arg Val Asn Lys Thr Cys Gly Leu Leu Val Gly Phe Thr Ile 195 200 205 Leu Gly Phe Asp Met Ile Phe Ile Ile Ile Ser Tyr Ile Leu Ile Phe

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210 215 220

Gln 225 Ala Val Phe Arg Leu 230 His Gln Lys Glu Ala Arg Leu Lys Ala Phe 235 240 Asn Thr Cys Thr Ala His Ile Phe Val Phe Leu Glu Phe Tyr Ile Leu 245 250 255 Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly His Val Ala Pro Pro 260 265 270 Thr His Ile Leu Leu Ser Thr Ile Tyr Leu Leu Val Pro Pro Ala Leu 275 280 285 Asn Pro Ile Val Tyr Gly Val Lys Asn Lys Val Ile Arg Arg Arg Val 290 295 300 Ala Gln Ile Phe Phe Leu Asn Cys Gln Ser Arg Gln

305 310 315 <210> 1369 <211> 510 <212> DNA <213> Canis familiaris <400> 1369 atggggtttc tgctatgggc tgtggctgtg atcctcccag gaccctttct cattaaacaa 60 ctcagctttt gtaaggctaa tgtgctctcc cactcatcct gcctacatcc agatatcatt 120 aagctctcct gttctgacca ccgaataaat agcatctatg gcctcatcat cattctcatc 180 atctttggag cagactctgt actcattctc ctctattatt tgaagattct gatcactgtg 240 caaggcattg cttcccggga agaactattc aaggccctta acacttgtgt gtcccacatt 300 tgtgctgtgc tgctggtgtc tgtccctgtg ctgggggtat ccattatcca ttgctttggg 360 aaacaggttc cacccatggt gcacactatc atgggttatg tatacctatt aattcctcct 420 gttctcgacc ctgttgtata ctgtgtggaa acccagggga tatgcacctg tattctggat 480 aatctactga aattattgca cagagtactt 510

Page 1540

069269_0225_SL.TXT <210> 1370 <211> 170 <212> PRT <213> Canis familiaris <400> 1370

Met Gly Phe Leu Leu Trp Ala Val Ala Val Ile Leu Pro Gly Pro Phe 1 5 10 15 Leu Ile Lys Gln Leu Ser Phe Cys Lys Ala Asn Val Leu Ser His Ser 20 25 30 Ser Cys Leu His Pro Asp Ile Ile Lys Leu Ser Cys Ser Asp His Arg 35 40 45 Ile Asn Ser Ile Tyr Gly Leu Ile Ile Ile Leu Ile Ile Phe Gly Ala 50 55 60 Asp Ser Val Leu Ile Leu Leu Tyr Tyr Leu Lys Ile Leu Ile Thr Val 65 70 75 80 Gln Gly Ile Ala Ser Arg Glu Glu Leu Phe Lys Ala Leu Asn Thr Cys 85 90 95 Val Ser His Ile Cys Ala Val Leu Leu Val Ser Val Pro Val Leu Gly 100 105 110 Val Ser Ile Ile His Cys Phe Gly Lys Gln Val Pro Pro Met Val His 115 120 125 Thr Ile Met Gly Tyr Val Tyr Leu Leu Ile Pro Pro Val Leu Asp Pro 130 135 140 Val Val Tyr Cys Val Glu Thr Gln Gly Ile Cys Thr Cys Ile Leu Asp 145 150 155 160 Asn Leu Leu Lys Leu Leu His Arg Val Leu

165 170 <210> 1371 <211> 960

Page 1541

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 1371

atggcaacct taaactccag taatagcctg tcctccacat tctatctcac aggtatccct 60 ggctatgagg aatttcacca ctggatatcc attccattct gtttcttcta ccttgtagga 120 ataatgggta actgcaccat cctgcatatt gttcggacag accccaggct ccatgagccc 180 atgtactact tcctggccat gctttccctt actgacatgg gcatgtccat gcccacaatg 240 atatcactct tcagggtgtt gtggtccatt tcccgggaaa tccagttcaa tatctgcgtg 300 gtgcaaatgt ttttcattca cactttctcc ttcactgaat catctgtgct cttggccatg 360 gcctttgacc gctatgtggc tatctgccac cctctacgat atgctatcat tctcacccca 420 agacttatca ttaaaattgg acttgcagct ctgcttagga gtgcctttgc catgattcca 480 cttttggcca ggttggcctt ctttcctttc tgccactccc acatcctttc tcattcctat 540 tgtctgcacc aggacatgat ttgtcttgcc tgtgctgaca caaagtttaa tgttatatac 600 gggttggttc ttattagtgc gctatggggc atggactctc tgggtatttt tgtgtcttat 660 atgtacattc tgcactcaat attaagaatt gcatcacgtg aggggaggct taaggccctc 720 aacacatgtg catcccacat ctgtgctgta ctcatcctat atgtgccgat gattgggctc 780 tctattgtcc atcgttttgc caaacactcc tctcccctca tccatatctt catggctcac 840 atctacttat tggttccacc cgtgcttaat ccaatcatct atagtgtgaa gaccaaacag 900 attcgccaag gagttctcca cctacttttc cccacaaaaa tcagttctac tatgatgtag 960

<210> 1372 <211> 319 <212> PRT <213> Canis familiaris

<400> 1372 Met Ala Thr Leu Asn Ser Ser Asn Ser Leu Ser Ser Thr Phe Tyr Leu 1 5 10 15 Thr Gly Ile Pro Gly Tyr Glu Glu Phe His His Trp Ile Ser Ile Pro 20 25 30 Phe Cys Phe Phe Tyr Leu Val Gly Ile Met Gly Asn Cys Thr Ile Leu Page 154; 2

069269_0225_SL.TXT 40 45

His Ile Val Arg Thr Asp Pro Arg Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Met Leu Ser Leu Thr Asp Met Gly Met Ser Met Pro Thr Met 65 70 75 80 Ile Ser Leu Phe Arg Val Leu Trp Ser Ile Ser Arg Glu Ile Gln Phe 85 90 95 Asn Ile Cys Val Val Gln Met Phe Phe Ile His Thr Phe Ser Phe Thr 100 105 110 Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg Tyr Ala Ile Ile Leu Thr Pro Arg Leu Ile Ile 130 135 140 Lys Ile Gly Leu Ala Ala Leu Leu Arg Ser Ala Phe Ala Met Ile Pro 145 150 155 160 Leu Leu Ala Arg Leu Ala Phe Phe Pro Phe Cys His Ser His Ile Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Met Ile Cys Leu Ala Cys Ala 180 185 190 Asp Thr Lys Phe Asn Val Ile Tyr Gly Leu Val Leu Ile Ser Ala Leu 195 200 205 Trp Gly Met Asp Ser Leu Gly Ile Phe Val Ser Tyr Met Tyr Ile Leu 210 215 220 His Ser Ile Leu Arg Ile Ala Ser Arg Glu Gly Arg Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Ala Ser His Ile Cys Ala Val Leu Ile Leu Tyr Val Pro

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245 250 255

Met Ile Gly Leu Ser Ile Val His Arg 265 Phe Ala Lys His Ser 270 Ser Pro 260 Leu Ile His Ile Phe Met Ala His Ile Tyr Leu Leu Val Pro Pro Val 275 280 285 Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Arg Gln Gly 290 295 300 Val Leu His Leu Leu Phe Pro Thr Lys Ile Ser Ser Thr Met Met 305 310 315

<210> 1373 <211> 990 <212> DNA <213> Canis familiaris <400> 1373

atggctacat gggacagact catgacaggc tctaactcca gtactgaaca gtctgttttg 60 ttttacctca ctgggattcc tggctatgag aatataaatc actttatttc catccctttt 120 tgcatgtgct acctgattgg agtagtgggc aactgcacaa tcctttacat catccgcaca 180 gacaagagtc tccacaagcc catgtactac ttcctggcca tgctgtccct tacggacatg 240 ggcatgtcct tttctaccct gcccacggta ttaaaaatct tctggtttga tgccagggaa 300 attgaggtga atgcttgtgt ggcccaaatg tattttattc atactttttc tctgatggag 360 tcagctgtgc ttctagccat ggcttttgac cggtatgttg ccatttgcca tcctttgagg 420 tattccagca aactcacccc acaatgcatt atctatatag gggtcttcat tatattcaga 480 tgctccattg tcctccctgt tgttcttgtt cgtattccta cattttcctt ctgtcattcc 540 catatcctct accactcttt ctgcttgcat caagaagtca tccatttggc ctgtgctgat 600 atctcattca acattttata tggcttgttt gtcattgcat tttattgggg tgtagattct 660 ctaggaattt tgttatctta tgctttcatc ttccattctg tcctaggcat tgcatcccag 720 ggagggaagc tcaaagctct caacacatgt gcttcccaca tttgtgctgt gctcattcta 780 tatgtgccca tgatagggct atccttggtg catcgtttcg caaaacactc ctctcccatt 840

Page 1544

069269_0225_SL.TXT gtccatataa ccatggctaa tatttacctg ctaattccac cagtacttaa tccaattatt tatagcatca agacaaagca gattcgtcaa ggttttctaa ggatattagc acccaaaaag gttgggtttt ctcacacttg gaagggataa

900

960

990 <210> 1374 <211> 329 <212> PRT <213> Canis familiaris

<400> 1374 Arg Leu Met Thr Gly Ser Asn Ser Ser Thr Glu Met Ala 1 Thr Trp Asp 5 10 15 Gln Ser Val Leu Phe Tyr Leu Thr Gly Ile Pro Gly Tyr Glu Asn Ile 20 25 30 Asn His Phe Ile Ser Ile Pro Phe Cys Met Cys Tyr Leu Ile Gly Val 35 40 45 Val Gly Asn Cys Thr Ile Leu Tyr Ile Ile Arg Thr Asp Lys Ser Leu 50 55 60 His Lys Pro Met Tyr Tyr Phe Leu Ala Met Leu Ser Leu Thr Asp Met 65 70 75 80 Gly Met Ser Phe Ser Thr Leu Pro Thr Val Leu Lys Ile Phe Trp Phe 85 90 95 Asp Ala Arg Glu Ile Glu Val Asn Ala Cys Val Ala Gln Met Tyr Phe 100 105 110 Ile His Thr Phe Ser Leu Met Glu Ser Ala Val Leu Leu Ala Met Ala 115 120 125 Phe Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Ser Ser Lys 130 135 140 Leu Thr Pro Gln Cys Ile Ile Tyr Ile Gly Val Phe Ile Ile Phe Arg 145 150 155 160

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Cys Ser Ile Val Leu Pro Val Val Leu Val Arg Ile Pro Thr Phe Ser 165 170 175 Phe Cys His Ser His Ile Leu Tyr His Ser Phe Cys Leu His Gln Glu 180 185 190 Val Ile His Leu Ala Cys Ala Asp Ile Ser Phe Asn Ile Leu Tyr Gly 195 200 205 Leu Phe Val Ile Ala Phe Tyr Trp Gly Val Asp Ser Leu Gly Ile Leu 210 215 220 Leu Ser Tyr Ala Phe Ile Phe His Ser Val Leu Gly Ile Ala Ser Gln 225 230 235 240 Gly Gly Lys Leu Lys Ala Leu Asn Thr Cys Ala Ser His Ile Cys Ala 245 250 255 Val Leu Ile Leu Tyr Val Pro Met Ile Gly Leu Ser Leu Val His Arg 260 265 270 Phe Ala Lys His Ser Ser Pro Ile Val His Ile Thr Met Ala Asn Ile 275 280 285 Tyr Leu Leu Ile Pro Pro Val Leu Asn Pro Ile Ile Tyr Ser Ile Lys 290 295 300 Thr Lys Gln Ile Arg Gln Gly Phe Leu Arg Ile Leu Ala Pro Lys Lys 305 310 315 320 Val Gly Phe Ser His Thr Trp Lys Gly

325 <210> 1375 <211> 960 <212> DNA <213> Canis familiaris <400> 1375

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atggcaacct taaactccag taatagcctg tcctccacat tctatctcac aggtatccct 60 ggctatgagg aatttcacca ttggatatcc attccattct gtctcctcta ccttgttgga 120 ataatgggta actgcaccat cctgcatatt gttcggacag accccaggct ccatgagccc 180 atgtactact tcctggccat gctttccctc actgacatgg gcatgtccat gcccacaatg 240 atatcactct tcagggtgtt gtggtccatt tcccgggaaa tccagttcaa tatctgtgtg 300 gtccaaatgt ttttcattca cactttctcc ttcactgaat catctgtgct cttggccatg 360 gcctttgacc gctatgtggc tatctgccac cctctacgat atgctaccat tctcacccca 420 agacttatca ttaaaattgg acttgcagcc ctgcttagga gtgcctttgc aatgattcca 480 cttttggcca ggttggcctt ctttcctttc tgccactccc acatcctttc tcattcctat 540 tgtctgcacc aggacatgat tcgtcttgcc tgtgctgaca caatgtttaa tattatatat 600 gggttgattc tggttattgt gctgtggggc atggactctc tgggtatttt tgtgtcttat 660 atgtacattc tgcactcaat attaagaatt gcatcacgtg aggggaggct taaggccctc 720 aacacatgtg catcccacat ctgtgtggta ctcatcctat atgtgccgat gattgggctc 780 tctattgtcc atcgttttgc caaacactcc tctcccctca tccacatctt catggctcac 840 atctacttat tagttccacc cgtgcttaat ccaatcatct atagtgtgaa gaccaaacag 900 attcgccaag gagttctcca ccttcttttc cccacaaaaa tcagttctac tatgatgtag 960

<210> 1376 <211> 319 <212> PRT <213> Canis familiaris

<400> 1376 Met 1 Ala Thr Leu Asn Ser Ser Asn Ser Leu Ser Ser Thr Phe Tyr Leu 5 10 15 Thr Gly Ile Pro Gly Tyr Glu Glu Phe His His Trp Ile Ser Ile Pro 20 25 30 Phe Cys Leu Leu Tyr Leu Val Gly Ile Met Gly Asn Cys Thr Ile Leu 35 40 45 His Ile Val Arg Thr Asp Pro Arg Leu His Glu Pro Met Tyr Tyr Phe Page 1547

069269_0225_SL.TXT

50 55 60 Leu Ala Met Leu Ser Leu Thr Asp Met Gly Met Ser Met Pro Thr Met 65 70 75 80 Ile Ser Leu Phe Arg Val Leu Trp Ser Ile Ser Arg Glu Ile Gln Phe 85 90 95 Asn Ile Cys Val Val Gln Met Phe Phe Ile His Thr Phe Ser Phe Thr 100 105 110 Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg Tyr Ala Thr Ile Leu Thr Pro Arg Leu Ile Ile 130 135 140 Lys Ile Gly Leu Ala Ala Leu Leu Arg Ser Ala Phe Ala Met Ile Pro 145 150 155 160 Leu Leu Ala Arg Leu Ala Phe Phe Pro Phe Cys His Ser His Ile Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Met Ile Arg Leu Ala Cys Ala 180 185 190 Asp Thr Met Phe Asn Ile Ile Tyr Gly Leu Ile Leu Val Ile Val Leu 195 200 205 Trp Gly Met Asp Ser Leu Gly Ile Phe Val Ser Tyr Met Tyr Ile Leu 210 215 220 His Ser Ile Leu Arg Ile Ala Ser Arg Glu Gly Arg Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Ala Ser His Ile Cys Val Val Leu Ile Leu Tyr Val Pro 245 250 255 Met Ile Gly Leu Ser Ile Val His Arg Phe Ala Lys His Ser Ser Pro

Page 1548

260

069269_0225_SL.TXT 265 270

Leu Ile His Ile Phe Met Ala His Ile Tyr Leu Leu Val Pro Pro Val 275 280 285 Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Arg Gln Gly 290 295 300 Val Leu His Leu Leu Phe Pro Thr Lys Ile Ser Ser Thr Met Met 305 310 315

<210> 1377 <211> 975 <212> DNA <213> Canis familiaris <400> 1377

atgtttcata taacagactt ggctcacctg tctgtaagaa tatccaactc tacatctgct 60 cacttcactg cctttctgct gactggagtc ccaggattag aagacttcca aatctggatc 120 tccatcccct tcagcttcat gtaccttttg gctgtgatag gcaatggtct ggttatggca 180 gtggtggcct gggacagaaa cctccatgaa cccatgtatc tcttcctggc catgttggca 240 ctcaatgatg ttttcctttg tacagtcaca gtgcccaaaa tgcttctcat cttctggcag 300 ggcccttccc catcaacgtt tcctgcatgt ctcacacaga tgttttttgt tcatgctctg 360 ttcctctctg agtctgctat tctcttggcc atggcttttg atcgctatgt ggctatctgt 420 gcaccactcc attatgcaac cctacttacc ggctctctta tcagcaaggt aggtctggct 480 ctggtggctc ggagtgtggc tgtggtcacc cctggtgtcc tcctcattct ccggttgcat 540 ttctgccgga gcaatgtcat ccaccatacc tactgtgaga acatgggcat tgccaagttg 600 gcctgtaata acatttccct taatagcatt tatgggctca ctgctgcact cctcaccaca 660 gggctagact ttgtcctcat ctccctgtcc tactgtctaa tcctgagaac agtcttccaa 720 ctaccttcta gagaagcccg gacaaaggcc tttggaacat gtggagctca tatatgtgtc 780 atcttgatat tttatactct agccttcttt tccttcttta cccatcgctt tggaaatcac 840 atacccaggc atgtccttat cctcctggca aacctctact tattggtgcc acctactatg 900 aaccctattg tttatggagt aaagacaaaa gagataagga tgcgtgtctt ggggctctgt 960

Page 1549

069269_0225_SL.TXT aaccaaccaa aatga

975 <210> 1378 <211> 324 <212> PRT <213> Canis familiaris

<400> 1378 Ile Thr Asp Leu Ala His 5 Leu Ser Val Arg Ile Ser Asn Met Phe 1 His 10 15 Ser Thr Ser Ala His Phe Thr Ala Phe Leu Leu Thr Gly Val Pro Gly 20 25 30 Leu Glu Asp Phe Gln Ile Trp Ile Ser Ile Pro Phe Ser Phe Met Tyr 35 40 45 Leu Leu Ala Val Ile Gly Asn Gly Leu Val Met Ala Val Val Ala Trp 50 55 60 Asp Arg Asn Leu His Glu Pro Met Tyr Leu Phe Leu Ala Met Leu Ala 65 70 75 80 Leu Asn Asp Val Phe Leu Cys Thr Val Thr Val Pro Lys Met Leu Leu 85 90 95 Ile Phe Trp Gln Gly Pro Ser Pro Ser Thr Phe Pro Ala Cys Leu Thr 100 105 110 Gln Met Phe Phe Val His Ala Leu Phe Leu Ser Glu Ser Ala Ile Leu 115 120 125 Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Ala Pro Leu His 130 135 140 Tyr Ala Thr Leu Leu Thr Gly Ser Leu Ile Ser Lys Val Gly Leu Ala 145 150 155 160 Leu Val Ala Arg Ser Val Ala Val Val Thr Pro Gly Val Leu Leu Ile 165 170 175

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Leu Arg Leu His Phe Cys Arg Ser Asn Val Ile His His Thr Tyr Cys 180 185 190 Glu Asn Met Gly Ile Ala Lys Leu Ala Cys Asn Asn Ile Ser Leu Asn 195 200 205 Ser Ile Tyr Gly Leu Thr Ala Ala Leu Leu Thr Thr Gly Leu Asp Phe 210 215 220 Val Leu Ile Ser Leu Ser Tyr Cys Leu Ile Leu Arg Thr Val Phe Gln 225 230 235 240 Leu Pro Ser Arg Glu Ala Arg Thr Lys Ala Phe Gly Thr Cys Gly Ala 245 250 255 His Ile Cys Val Ile Leu Ile Phe Tyr Thr Leu Ala Phe Phe Ser Phe 260 265 270 Phe Thr His Arg Phe Gly Asn His Ile Pro Arg His Val Leu Ile Leu 275 280 285 Leu Ala Asn Leu Tyr Leu Leu Val Pro Pro Thr Met Asn Pro Ile Val 290 295 300 Tyr Gly Val Lys Thr Lys Glu Ile Arg Met Arg Val Leu Gly Leu Cys 305 310 315 320

Asn Gln Pro Lys <210> 1379 <211> 945 <212> DNA <213> Canis familiaris <400> 1379 atggtctttt tcaatagtag tacctacaga ccctttcttc tgagtggttt ccctggtctg gaagactcac atccagtgat ttccattttg ttttgtgccc tctacctggt tgccctaatg

120

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gggaacatca tcatccttgt ggttattcgg gtggaacagt cacttcatgc acccatgtac 180 ttttttctct ccatgctggc tgctactgac ctgggactct gcactgccac cctacccacc 240 atgctccagc ttttctggtt taaagtttgt gaaatagact ttgatgcctg cctcacccag 300 atgttcttca ttcatgtgtt ttccttaatg gagtcaggca tcctcctcac catggctttt 360 gaccgctatg tggccatctc caacccactc aggtacacta ctattttgac tgagtccacc 420 atcaccaaga taggtgtggg gcttctgcta cgggctgtgg ctgtcatcct cccaggaccc 480 tttctcatta aacgactcag cttttgtaag gctaatgtgc tctcccactc atactgccta 540 catccagata tcattaagct ctcctgttct gaccaccgaa taaatagcat ctatggcctc 600 atcatcattc tcatcacctt tggagcagac tctgtactca tcctcttctc ttatttgaag 660 attctgatca ctgttcaagg cattgcctcc aaggaagaac aattcaaggc ccttaacact 720 tgtgtgtccc acatctgtgc tgtgctgctg gtgtatatcc ctatgctggg ggtatccatt 780 atccatcgct ttgggaaaca tgttccaccc atggtgcaca ttatcatggg ttatgtatac 840 ctattgattc ctcctgttct caaccctgtt gtatactgtg tgaaaaccca ggggatacgc 900 acccgtattc tgggtaatct gaaattacag cagagagtac tttag 945

<210> 1380 <211> 314 <212> PRT

<213> Canis familiaris <400> 1380 Met Val Phe Phe Asn Ser Ser Thr Tyr Arg Pro Phe Leu Leu Ser Gly 1 5 10 15 Phe Pro Gly Leu Glu Asp Ser His Pro Val Ile Ser Ile Leu Phe Cys 20 25 30 Ala Leu Tyr Leu Val Ala Leu Met Gly Asn Ile Ile Ile Leu Val Val 35 40 45 Ile Arg Val Glu Gln Ser Leu His Ala Pro Met Tyr Phe Phe Leu Ser 50 55 60 Met Leu Ala Ala Thr Asp Leu Gly Leu Cys Thr Ala Thr Leu Pro Thr

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Met Leu Gln Leu Phe Trp Phe Lys Val Cys Glu Ile Asp Phe Asp Ala 85 90 95 Cys Leu Thr Gln Met Phe Phe Ile His Val Phe Ser Leu Met Glu Ser 100 105 110 Gly Ile Leu Leu Thr Met Ala Phe Asp Arg Tyr Val Ala Ile Ser Asn 115 120 125 Pro Leu Arg Tyr Thr Thr Ile Leu Thr Glu Ser Thr Ile Thr Lys Ile 130 135 140 Gly Val Gly Leu Leu Leu Arg Ala Val Ala Val Ile Leu Pro Gly Pro 145 150 155 160 Phe Leu Ile Lys Arg Leu Ser Phe Cys Lys Ala Asn Val Leu Ser His 165 170 175 Ser Tyr Cys Leu His Pro Asp Ile Ile Lys Leu Ser Cys Ser Asp His 180 185 190 Arg Ile Asn Ser Ile Tyr Gly Leu Ile Ile Ile Leu Ile Thr Phe Gly 195 200 205 Ala Asp Ser Val Leu Ile Leu Phe Ser Tyr Leu Lys Ile Leu Ile Thr 210 215 220 Val Gln Gly Ile Ala Ser Lys Glu Glu Gln Phe Lys Ala Leu Asn Thr 225 230 235 240 Cys Val Ser His Ile Cys Ala Val Leu Leu Val Tyr Ile Pro Met Leu 245 250 255 Gly Val Ser Ile Ile His Arg Phe Gly Lys His Val Pro Pro Met Val 260 265 270 His Ile Ile Met Gly Tyr Val Tyr Leu Leu Ile Pro Pro Val Leu Asn

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275 280 285

Pro Val Val Tyr Cys Val Lys Thr Gln Gly Ile Arg Thr Arg Ile Leu 290 295 300

Gly Asn Leu Lys Leu Gln Gln Arg Val Leu 305 310 <210> 1381 <211> 906 <212> DNA <213> Canis familiaris <400> 1381

aataatacca atttccatcc caatactttt cttctccttg gcattccagg aatggaggct 60 atccacgctt gtctgtcaat gcctttctgt tttgtctacc tgagtgctct cctgggtatt 120 tttgctattc tatttataat cagaacagac tccaatctgc atgagcccat gttcttcttc 180 ctctgtatgc tctctgtgac tgacatgatc atctccacta ctgtcaggcc caaaatgcta 240 agcatatttt ggttccatgg cagtgagatc tattttgaag cccttgtaca agtgtttctc 300 attcatttca ttcattcatt atgcatcatg gcctcagggt ttatcttggc catggccttt 360 gacaggtatg tggcaatctg tgatcctctg agacattcta ctatcctgac acatggaatc 420 atcaagaact tggggctggt tattgtcttc cgtggggttt tgctcttcag tcctcaacca 480 tttatgcttc ggtggcttcc ttactgtaga attaatatca tcccccacac tatgaattta 540 tggcacggat caagcttgct tatgcagaga ccagaatcta cagaatctac acctgactgc 600 tgccttcttc actggaggtt tagatttctt attgatccta tgttcctgtt atcattctct 660 acactgtctt ccatcttcca ttcaaggctg ctcggctcaa gaccttaggc acatgtggat 720 cccatttgtg tgatctcagt agcctacact ccagcctttt tcttcttcct tactcacaga 780 tttggtcacc atatggctcc tcatactcat atctttgtgg ctaacatata tcttctagtt 840 ccacccatgg taaacccatt gatctatggc ataagaacca agaggatcag agatcgagtc 900

cttcaa 906 <210> 1382 <211> 235

Page 1554

069269_0225_SL.TXT familiaris <212> PRT <213> Canis <400> 1382 Asn Asn Thr 1

Gly Met Glu

Tyr Leu Ser 35

Thr Asp Ser 50

Ser Val Thr 65

Ser Ile Phe

Gln Val Phe

Gly Phe Ile 115

Pro Leu Arg 130

Gly Leu Val 145

Phe Met Leu

Thr Met Asn

Asn Phe His 5 Pro Asn Thr Phe Leu Leu Leu Gly Ile Pro 10 15 Ala Ile His Ala Cys Leu Ser Met Pro Phe Cys Phe Val 20 25 30 Ala Leu Leu Gly Ile Phe Ala Ile Leu Phe Ile Ile Arg 40 45 Asn Leu His Glu Pro Met Phe Phe Phe Leu Cys Met Leu 55 60 Asp Met Ile Ile Ser Thr Thr Val Arg Pro Lys Met Leu 70 75 80 Trp Phe His Gly Ser Glu Ile Tyr Phe Glu Ala Leu Val 85 90 95 Leu Ile His Phe Ile His Ser Leu Cys Ile Met Ala Ser 100 105 110 Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asp 120 125 His Ser Thr Ile Leu Thr His Gly Ile Ile Lys Asn Leu 135 140 Ile Val Phe Arg Gly Val Leu Leu Phe Ser Pro Gln Pro 150 155 160 Arg Trp Leu Pro Tyr Cys Arg Ile Asn Ile Ile Pro His 165 170 175 Leu Trp His Gly Ser Ser Leu Leu Met Gln Arg Pro Glu 180 185 190

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Ser Thr Glu Ser Thr Pro Asp Cys Cys Leu Leu His Trp Arg Phe Arg 195 200 205

Phe Leu Ile Asp Pro Met Phe Leu Leu Ser Phe Ser Thr Leu Ser Ser 210 215 220

Ile Phe His Ser Arg Leu Leu Gly Ser Arg Pro 225 230 235 <210> 1383 <211> 525 <212> DNA <213> Canis familiaris <400> 1383 cccccagaat gcagcttgaa tcaacccatg tacatcttcc tagcagtgct ggcagccact 60 gacataggac tctgtgtagc tattgctccc aagatggtgg ccatcttctg gtttggctgc 120 tgctccgtgg cttttgaggc ttgcttagcc cagcttttct tcatccacgc cttgcagggc 180 atggaatctg gcatcctgtt ggccatggcc tttgactgca atgttggcat ctatgatcca 240 ctgagtcaca catccatcct cacacctttc atcttggtta ctatggtgct gtttgtggaa 300 attcaagcaa tagtacttgt tgatattttt ccagttttaa tcaaaagact acatattttc 360 tattccagtg taactaccaa catggctgtg gtcaagctag ctgcagaaga catccaagtc 420 aataacacat gtggtctcct tgtagtttta catacagtga taaataaata aataacatac 480 atgttatttt cctcatccta tacccttatt ttccaggcca ttttt 525 <210> 1384 <211> 156 <212> PRT <213> Canis familiaris <400> 1384

Pro Pro Glu Cys Ser Leu Asn Gln Pro Met Tyr Ile Phe Leu Ala Val 1 5 10 15

Leu Ala Ala Thr Asp Ile Gly Leu Cys Val Ala Ile Ala Pro Lys Met 20 25 30

Val Ala Ile Phe Trp Phe Gly Cys Cys Ser Val Ala Phe Glu Ala Cys Page 1556

069269_0225_SL.TXT 40 45

Leu Ala Gln Leu Phe Phe Ile His Ala Leu Gln Gly Met Glu Ser Gly 50 55 60 Ile Leu Leu Ala Met Ala Phe Asp Cys Asn Val Gly Ile Tyr Asp Pro 65 70 75 80 Leu Ser His Thr Ser Ile Leu Thr Pro Phe Ile Leu Val Thr Met Val 85 90 95 Leu Phe Val Glu Ile Gln Ala Ile Val Leu Val Asp Ile Phe Pro Val 100 105 110 Leu Ile Lys Arg Leu His Ile Phe Tyr Ser Ser Val Thr Thr Asn Met 115 120 125 Ala Val Val Lys Leu Ala Ala Glu Asp Ile Gln Val Asn Asn Thr Cys 130 135 140 Gly Leu Leu Val Val Leu His Thr Val Ile Asn Lys 145 150 155

<210> 1385 <211> 942 <212> DNA <213> Canis familiaris <400> 1385

atgtctgctt cttctgcttc cattatcaat tcctccatat tcattctcac tggtttccct 60 ggcctagacc agtactaccc ctggttttca attccctttt cttttgtcta tgctatggtc 120 tttctgggaa actgcctggt gctgcacgtg atcaggactg agccgagcct gcaccagccc 180 atgttctact tcctggccat gctggccctc actgacctgt gcatggggct gtccacggtg 240 cacacggtgc tgggggtctt gtgggggctc aatcaagaag tcagtcagga tgcctgcatt 300 gcccaaactt acttcatcca tggtctgtca tgcatggagt ctggagtcct tcttgccatg 360 gcctttgatc gcttcactgc aatctgcaat cctctgcgct acacatccat cctgaccaac 420 agtagagtca ttcatttcat ggtgaccatt ctgatgaggg ctgctttgtc cattctccca 480

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gtcatcattc gcctgaagtt cttccattac tgccgccccc acatcctctc ccactctttc 540 tgcctgcacc aggacctact ccggctggcc tgctccgaca tccgcttcaa cagcttctat 600 gccctggctc tggtgatttg taccttgctg ttggatgctg tgctcattct catctcctac 660 attctcatct tgcacacagt gctggcgatt gcatcccagg aggagaggct taagtccttg 720 cagacctgtg tgtcccacat ctgtgctgtc ctggtctttt acatccccat cattggcctc 780 accatggtgc accgctttgg aaagcatctc tcaccttctg ttcatgtcct tatgggcaat 840 atctatattc ttttcccacc cctgatgaat cccatcatct acagtgtaaa gacccagcag 900 atccggggca ggatgaagaa gtggttttcc ctgaaaatgt ag 942

<210> 1386 <211> 313 <212> PRT <213> Canis familiaris <400> 1386

Met Ser Ala Ser Ser Ala Ser Ile Ile Asn Ser Ser Ile Phe Ile Leu 1 5 10 15 Thr Gly Phe Pro Gly Leu Asp Gln Tyr Tyr Pro Trp Phe Ser Ile Pro 20 25 30 Phe Ser Phe Val Tyr Ala Met Val Phe Leu Gly Asn Cys Leu Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Val 65 70 75 80 His Thr Val Leu Gly Val Leu Trp Gly Leu Asn Gln Glu Val Ser Gln 85 90 95 Asp Ala Cys Ile Ala Gln Thr Tyr Phe Ile His Gly Leu Ser Cys Met 100 105 110

Page 1558

Glu Ser Gly 115 Val Leu Leu Ala 069269_0225_SL.TXT Met Ala Phe Asp Arg Phe 120 125 Thr Ala Ile Cys Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr Asn Ser Arg Val Ile 130 135 140 His Phe Met Val Thr Ile Leu Met Arg Ala Ala Leu Ser Ile Leu Pro 145 150 155 160 Val Ile Ile Arg Leu Lys Phe Phe His Tyr Cys Arg Pro His Ile Leu 165 170 175 Ser His Ser Phe Cys Leu His Gln Asp Leu Leu Arg Leu Ala Cys Ser 180 185 190 Asp Ile Arg Phe Asn Ser Phe Tyr Ala Leu Ala Leu Val Ile Cys Thr 195 200 205 Leu Leu Leu Asp Ala Val Leu Ile Leu Ile Ser Tyr Ile Leu Ile Leu 210 215 220 His Thr Val Leu Ala Ile Ala Ser Gln Glu Glu Arg Leu Lys Ser Leu 225 230 235 240 Gln Thr Cys Val Ser His Ile Cys Ala Val Leu Val Phe Tyr Ile Pro 245 250 255 Ile Ile Gly Leu Thr Met Val His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Ser Val His Val Leu Met Gly Asn Ile Tyr Ile Leu Phe Pro Pro Leu 275 280 285 Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Gln Gln Ile Arg Gly Arg 290 295 300 Met Lys Lys Trp Phe Ser Leu Lys Met

305 310

Page 1559

069269_0225_SL.TXT <210> 1387 <211> 948 <212> DNA <213> Canis familiaris <400> 1387

atgcagttca caaactacag ccagcagaac ccaaactctt ttctgctcat gggaattcct 60 ggcctggagg catctcactt ttggattgca tttcccttct gctccatgta tgcactagca 120 gtgtttggca acatggcagt gctgctggtg gtgcgatcgg agcctgccct gcaccagccc 180 atgtacctat tcctatgtat gctgtccatc attgacctgg tactctgcac ttctactgtg 240 cccaagctcc ttgcactttt ttggacaaat gatactgaga tcaactttgg ggcctgtgct 300 acccagatgt tttttatcca tggcttttca gctgttgaat ctggtatcct gctagcaatg 360 gcctttgacc gctacttggc catctgccag ccactccact atgggtcatt gttgcctcca 420 gaggctgtgg gcaagctggc agctgctgct gtgtttcgtg gcttggggct catgacccca 480 ctcacctgct tactggcaag actgagctac tgtagccgag tggtggccca ttcctactgt 540 gagcatatgg ctgtggtaaa gctggcatgt gggggcacac ggccaaacaa catctatggc 600 atcactgctg ccacactagt tgtgggcaca gactcaattt gcatcgctgt ctcctatgcg 660 ctcatcctcc gggctgtgtt aggcctctcc tccaaagaag caagggctaa gacatttggt 720 acttgtggct cccacctggg tgtcattctt ctcttctata caccaggact cttctcattc 780 tacacacaac gctttggcca gcatgttccc cggcacatcc acatcctcct ggctgacctc 840 taccttgttg taccacccat gctcaaccct atcatctatg gcatgaagac caaacagatc 900 cgggttggag ccctccgact gctgaagcgg ggcattgttc agtcttaa 948

<210> 1388 <211> 315 <212> PRT <213> Canis familiaris <400> 1388

Met Gln Phe Thr Asn Tyr Ser Gln Gln Asn Pro Asn Ser Phe Leu Leu 1 5 10 15 Met Gly Ile Pro Gly Leu Glu Ala Ser His Phe Trp Ile Ala Phe Pro

20 25 30

Page 1560

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Phe Cys Ser 35 Met Tyr Ala Leu Ala Val Phe Gly Asn Met Ala Val Leu 40 45 Leu Val Val Arg Ser Glu Pro Ala Leu His Gln Pro Met Tyr Leu Phe 50 55 60 Leu Cys Met Leu Ser Ile Ile Asp Leu Val Leu Cys Thr Ser Thr Val 65 70 75 80 Pro Lys Leu Leu Ala Leu Phe Trp Thr Asn Asp Thr Glu Ile Asn Phe 85 90 95 Gly Ala Cys Ala Thr Gln Met Phe Phe Ile His Gly Phe Ser Ala Val 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Leu Ala Ile 115 120 125 Cys Gln Pro Leu His Tyr Gly Ser Leu Leu Pro Pro Glu Ala Val Gly 130 135 140 Lys Leu Ala Ala Ala Ala Val Phe Arg Gly Leu Gly Leu Met Thr Pro 145 150 155 160 Leu Thr Cys Leu Leu Ala Arg Leu Ser Tyr Cys Ser Arg Val Val Ala 165 170 175 His Ser Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys Gly Gly 180 185 190 Thr Arg Pro Asn Asn Ile Tyr Gly Ile Thr Ala Ala Thr Leu Val Val 195 200 205 Gly Thr Asp Ser Ile Cys Ile Ala Val Ser Tyr Ala Leu Ile Leu Arg 210 215 220 Ala Val Leu Gly Leu Ser Ser Lys Glu Ala Arg Ala Lys Thr Phe Gly 225 230 235 240

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Thr Cys Gly Ser His Leu Gly Val Ile Leu Leu Phe Tyr Thr Pro Gly 245 250 255 Leu Phe Ser Phe Tyr Thr Gln Arg Phe Gly Gln His Val Pro Arg His 260 265 270 Ile His Ile Leu Leu Ala Asp Leu Tyr Leu Val Val Pro Pro Met Leu 275 280 285 Asn Pro Ile Ile Tyr Gly Met Lys Thr Lys Gln Ile Arg Val Gly Ala 290 295 300 Leu Arg Leu Leu Lys Arg Gly Ile Val Gln Ser 305 310 315

<210> 1389 <211> 951 <212> DNA <213> Canis familiaris <400> 1389 atgtcagact ccaaccacac cggtaccttt ttcttcctag caggcctccc aggcattgag gctgtgcaca aatggctctt tatccctctg tgtgccatgt atgtggcctc cctggtaggg aacagtctga tcctgtgggt ggtgaggtca gagccctccc tgcaccagcc catgtactac ttcctattga tgctggcagt gaccgacctg ggtctgtctg cctccacact gcccactgtg ctccccatct acctgctggg tctcaggaaa gtggcaatgg atatgtgtct ggcccagctc ttcttcatcc acaccttctc catcatggag tcctctgtgc tgctgactat ggccttggac cgttttgtgg ccatcagcaa ccccctgcac tatggcacca tcctcacaag cccccgtgtt gctagcttag gcctggccag tgtggtgcgc agtgtcgggc ttcacatccc cgctcccatc atgctgagga aactgcctta ttgccagaat cgcctgcttt cccattccta ctgtctgcac ccggatgtca tgaagctggc ctgtgtagac acccacatca acagtgccta tggtcttttt gtagtgctct ctacactagg ggtggactcg gtgctcattg ttctctccta tgtgctgatc ctccaaacag cgctgtccat tgcctccaaa gctgagcgcc ttaaagccct caacacttgt gtctcccata tctgtgctgt gctgctcttc tacacaccga tgattggcct gtccatgatc

120

180

240

300

360

420

480

540

600

660

720

780

Page 1562

069269_0225_SL.TXT cacagatttg ggaggtgggc ttccccttcc agccgggtgc tgctctccta cgttcacttt ctcatacctc cagtgctcaa tccagtagtt tacaccatta agaccaagca gatccggctg aggatgctac gcttattggg gtcaggtggg gctggcatca gagacactta g

840

900

951 <210> 1390 <211> 316 <212> PRT <213> Canis familiaris

<400> 1390 His Thr Gly Thr Phe Phe Phe Leu Ala Gly Leu Met Ser 1 Asp Ser Asn 5 10 15 Pro Gly Ile Glu Ala Val His Lys Trp Leu Phe Ile Pro Leu Cys Ala 20 25 30 Met Tyr Val Ala Ser Leu Val Gly Asn Ser Leu Ile Leu Trp Val Val 35 40 45 Arg Ser Glu Pro Ser Leu His Gln Pro Met Tyr Tyr Phe Leu Leu Met 50 55 60 Leu Ala Val Thr Asp Leu Gly Leu Ser Ala Ser Thr Leu Pro Thr Val 65 70 75 80 Leu Pro Ile Tyr Leu Leu Gly Leu Arg Lys Val Ala Met Asp Met Cys 85 90 95 Leu Ala Gln Leu Phe Phe Ile His Thr Phe Ser Ile Met Glu Ser Ser 100 105 110 Val Leu Leu Thr Met Ala Leu Asp Arg Phe Val Ala Ile Ser Asn Pro 115 120 125 Leu His Tyr Gly Thr Ile Leu Thr Ser Pro Arg Val Ala Ser Leu Gly 130 135 140 Leu Ala Ser Val Val Arg Ser Val Gly Leu His Ile Pro Ala Pro Ile 145 150 155 160

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Met Leu Arg Lys Leu Pro Tyr Cys Gln Asn Arg Leu Leu Ser His Ser 165 170 175 Tyr Cys Leu His Pro Asp Val Met Lys Leu Ala Cys Val Asp Thr His 180 185 190 Ile Asn Ser Ala Tyr Gly Leu Phe Val Val Leu Ser Thr Leu Gly Val 195 200 205 Asp Ser Val Leu Ile Val Leu Ser Tyr Val Leu Ile Leu Gln Thr Ala 210 215 220 Leu Ser Ile Ala Ser Lys Ala Glu Arg Leu Lys Ala Leu Asn Thr Cys 225 230 235 240 Val Ser His Ile Cys Ala Val Leu Leu Phe Tyr Thr Pro Met Ile Gly 245 250 255 Leu Ser Met Ile His Arg Phe Gly Arg Trp Ala Ser Pro Ser Ser Arg 260 265 270 Val Leu Leu Ser Tyr Val His Phe Leu Ile Pro Pro Val Leu Asn Pro 275 280 285 Val Val Tyr Thr Ile Lys Thr Lys Gln Ile Arg Leu Arg Met Leu Arg 290 295 300 Leu Leu Gly Ser Gly Gly Ala Gly Ile Arg Asp Thr

305 310 315 <210> 1391 <211> 948 <212> DNA <213> Canis familiaris <400> 1391 atgacaattc ttaacaacaa taatgccagc agcttcatct ttatactgat ggatctccca ggactggagg ctgctcattg ctggacagct attcctatct gctctgtcta tgctctatct

120

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ttgctgggta acatcaccat aatgtacatt gtcaagtctg tgcccagcct ccacacaccc 180 atgtacctct tcctgtccat gctttcaatg gctgacttgg gcctctcagc ttctacacta 240 ccttcaatgg cagctgtttt tctcctaggc cagagaaagg tgggagctgc aacttgcttt 300 atgcaactct tcttcatcca tactttctca gttattgaat cagctgtgct cttggccatg 360 gctttcgacc gctgtgtggc tatccgagag cccttacgct atgccaccat tcttacaacc 420 aagcgcattg gtgccattgg gctagccatt gtcacccgta gtgctgctct ccatctgccc 480 cttcctgtgc tccttagaag actgcaattt cagcctgtga atgctctgtc tcattcatac 540 tgcgttcatc ctgatgtttt aaggctagcc agttctagca ctcttgtgaa cagtagcttt 600 gggctctttg tcatgctttc tacactagga ttggatgctg tactcattct cctctcctat 660 gtgctaatct taagaacagt attgagcatt gcttccaaca cggagcggct taaaaccctt 720 aacacctgca tttcccatat ctgtgctgta ttactatttt ataccccact ggtcagcctg 780 tcgatgattc atcgctttgg aaaaatgaag ctaccagctc aggtatatat gcttctctcc 840 tatctgcact ttcttgttcc tccgatgctc aacccaattg tctacagtgt gaaaaccaaa 900 gagattcggg tacgcattgt aaagatgctc ctcccaagaa aacactga 948

<210> 1392 <211> 315 <212> PRT <213> Canis familiaris

<400> 1392 Asn Asn Asn Ala Ser Ser Phe Ile Phe Ile Leu Met 1 Thr Ile Leu Asn 5 10 15 Met Asp Leu Pro Gly Leu Glu Ala Ala His Cys Trp Thr Ala Ile Pro 20 25 30 Ile Cys Ser Val Tyr Ala Leu Ser Leu Leu Gly Asn Ile Thr Ile Met 35 40 45 Tyr Ile Val Lys Ser Val Pro Ser Leu His Thr Pro Met Tyr Leu Phe 50 55 60

Leu Ser Met

Leu Ser Met Ala Asp

Leu Gly Leu Ser Ala Page 1565

Ser Thr

Leu

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Pro Ser Met Ala Ala Val Phe Leu Leu Gly Gln Arg Lys Val Gly Ala 85 90 95 Ala Thr Cys Phe Met Gln Leu Phe Phe Ile His Thr Phe Ser Val Ile 100 105 110 Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Cys Val Ala Ile 115 120 125 Arg Glu Pro Leu Arg Tyr Ala Thr Ile Leu Thr Thr Lys Arg Ile Gly 130 135 140 Ala Ile Gly Leu Ala Ile Val Thr Arg Ser Ala Ala Leu His Leu Pro 145 150 155 160 Leu Pro Val Leu Leu Arg Arg Leu Gln Phe Gln Pro Val Asn Ala Leu 165 170 175 Ser His Ser Tyr Cys Val His Pro Asp Val Leu Arg Leu Ala Ser Ser 180 185 190 Ser Thr Leu Val Asn Ser Ser Phe Gly Leu Phe Val Met Leu Ser Thr 195 200 205 Leu Gly Leu Asp Ala Val Leu Ile Leu Leu Ser Tyr Val Leu Ile Leu 210 215 220 Arg Thr Val Leu Ser Ile Ala Ser Asn Thr Glu Arg Leu Lys Thr Leu 225 230 235 240 Asn Thr Cys Ile Ser His Ile Cys Ala Val Leu Leu Phe Tyr Thr Pro 245 250 255 Leu Val Ser Leu Ser Met Ile His Arg Phe Gly Lys Met Lys Leu Pro 260 265 270 Ala Gln Val Tyr Met Leu Leu Ser Tyr Leu His Phe Leu Val Pro Pro

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275 280 285 Met Leu Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Glu Ile Arg Val 290 295 300 Arg Ile Val Lys Met Leu Leu Pro Arg Lys His 305 310 315

<210> 1393 <211> 969 <212> DNA <213> Canis familiaris <400> 1393

atgttgtcca tcaatagtac caaagccgtt ttctccacct ttctggtgac aggcatacct 60 ggactggaag ctgtgcacat ctggatctct atacccttct ccaccatgtt cttcattacc 120 ttggtgggca atgtgaccat tctgacagtt atttgcaggg aacggaccct ccatgtgcct 180 atgtacctct tcctggccat gctagcagtg tctgacctgg gtctgtccct cttcactttc 240 cccacaatgc tgaggatctt ctggctggat actcgagagc tcaccttctc tgcctgcttc 300 acccaaatgt tttttattca taccttccag gattttgagt cagctattat actggcaatg 360 gcctttgacc ggtatgtggc catttctcat ccattgcgct attcttccat tctcaccagc 420 agcgctattt ccaggatagg tttggccatt gtagtgcgaa ccttgactgt acaggtgcct 480 ctccccatcc ttttgcgaag gctgtgcttc tgtcattcca atgtactatc tcattcctac 540 tgcctgcacc ccgatattat aaagctctct tgctccaaca ccaggatcaa tagcatcttt 600 ggactgtttg tggtattatc cacgatggga cttgattttc tcctcattct cttttcatac 660 atcctgatac tgaaaactgt cctgagcatt gcatcctctg gtggccgcct caaggctctc 720 aacacctgta tttcccacat ctgtgctgtg attctcttct tcacacccat gatatgccta 780 tctattctgc accgctttgg cccaaaactt ccctcacata tctacgtgac catggctaac 840 atgcattttc tcattcctcc tgtaatgaac cccattgtgt atgtggcgaa aaccaaacag 900 atacgagata aaattctgaa agttttcatc aaaaaagaac cagaatccca agtcacattt 960

ataacatga 969

Page 1567

069269_0225_SL.TXT <210> 1394 <211> 322 <212> PRT <213> Canis familiaris

<400> 1394 Asn Ser Thr Lys Ala Val Phe Ser Thr Phe Leu Val Met 1 Leu Ser Ile 5 10 15 Thr Gly Ile Pro Gly Leu Glu Ala Val His Ile Trp Ile Ser Ile Pro 20 25 30 Phe Ser Thr Met Phe Phe Ile Thr Leu Val Gly Asn Val Thr Ile Leu 35 40 45 Thr Val Ile Cys Arg Glu Arg Thr Leu His Val Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Ala Val Ser Asp Leu Gly Leu Ser Leu Phe Thr Phe 65 70 75 80 Pro Thr Met Leu Arg Ile Phe Trp Leu Asp Thr Arg Glu Leu Thr Phe 85 90 95 Ser Ala Cys Phe Thr Gln Met Phe Phe Ile His Thr Phe Gln Asp Phe 100 105 110 Glu Ser Ala Ile Ile Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Ser His Pro Leu Arg Tyr Ser Ser Ile Leu Thr Ser Ser Ala Ile Ser 130 135 140 Arg Ile Gly Leu Ala Ile Val Val Arg Thr Leu Thr Val Gln Val Pro 145 150 155 160 Leu Pro Ile Leu Leu Arg Arg Leu Cys Phe Cys His Ser Asn Val Leu 165 170 175 Ser His Ser Tyr Cys Leu His Pro Asp Ile Ile Lys Leu Ser Cys Ser 180 185 190

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Asn Thr Arg 195 Ile Asn Ser Ile Phe Gly Leu Phe Val Val Leu Ser Thr 200 205 Met Gly Leu Asp Phe Leu Leu Ile Leu Phe Ser Tyr Ile Leu Ile Leu 210 215 220 Lys Thr Val Leu Ser Ile Ala Ser Ser Gly Gly Arg Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Ile Ser His Ile Cys Ala Val Ile Leu Phe Phe Thr Pro 245 250 255 Met Ile Cys Leu Ser Ile Leu His Arg Phe Gly Pro Lys Leu Pro Ser 260 265 270 His Ile Tyr Val Thr Met Ala Asn Met His Phe Leu Ile Pro Pro Val 275 280 285 Met Asn Pro Ile Val Tyr Val Ala Lys Thr Lys Gln Ile Arg Asp Lys 290 295 300 Ile Leu Lys Val Phe Ile Lys Lys Glu Pro Glu Ser Gln Val Thr Phe 305 310 315 320

Ile Thr <210> 1395 <211> 957 <212> DNA <213> Canis familiaris <400> 1395 atgttggctt ttaatagcac tgcctctaat tggcccactt tctccttcat tggtattcct ggtctggagg ctgcacatat atggatctcc atccccttct gtgtcctgta catcatggcc cttgggggca atgctcttct gcttatccta gttacagcag agcagaatct tcatgaacct cagttctatt ttttggctgt gcttgctctt actgacctag gtctttcatt gtctacaatg

120

180

240

Page 1569

069269_0225_SL.TXT cctagtgtct tggctgtctt ctggtttgat gcccgacaca ttggcctgga tgcctgctta acccaaatgt tcttcattca ctccctctcc tcagtagaat caggtattct tgtggccatg gcttttgacc gtttggtagc tatctgcgct ccattaaact acaccaggat ccttacccac tatactgttg cctgccttag tggagctgct gtcttacgag gcgccactct gctggctcct ctgccttttt tccttaagac ttttcctttc tgtgggacca atatcctctc acattcttat tgctactacc cagatatgct caacctggcc tgtggggatg tctctttcag cagtgcctat gggttggttt ttgtcctttg cacatttgca gtggatgttg tcttcatcat agcttcatat atgaagatct tgggcactat tatgaacctg gagactcaag acagaaactg gaaatcactg cacacttgtg cctgccacct gtgcacagtg cttgtgtttt acctgcccct catcagcttg gcagtgctgc atcgttacag ccgggatgct tctccagttc tgtataccac catgagtaat gcctacctcc tcatgacacc actactcaac cctcttgtct acagtgtcaa atccaggcag atccaggctg ctctgcgcaa gcgattttgg gtgcaacgtg tcattgctgg ggaatga <210> 1396 <211> 318 <212> PRT <213> Canis familiaris

300

360

420

480

540

600

660

720

780

840

900

957

<400> 1396 Met Leu Ala Phe Asn Ser Thr Ala Ser Asn Trp Pro Thr Phe Ser Phe 1 5 10 15

Ile Gly Ile Pro Gly Leu Glu Ala Ala His Ile Trp Ile Ser Ile Pro 20 25 30 Phe Cys Val Leu Tyr Ile Met Ala Leu Gly Gly Asn Ala Leu Leu Leu 35 40 45 Ile Leu Val Thr Ala Glu Gln Asn Leu His Glu Pro Gln Phe Tyr Phe 50 55 60 Leu Ala Val Leu Ala Leu Thr Asp Leu Gly Leu Ser Leu Ser Thr Met 65 70 75 80 Pro Ser Val Leu Ala Val Phe Trp Phe Asp Ala Arg His Ile Gly Leu

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85 90 95 Asp Ala Cys Leu Thr Gln Met Phe Phe Ile His Ser Leu Ser Ser Val 100 105 110 Glu Ser Gly Ile Leu Val Ala Met Ala Phe Asp Arg Leu Val Ala Ile 115 120 125 Cys Ala Pro Leu Asn Tyr Thr Arg Ile Leu Thr His Tyr Thr Val Ala 130 135 140 Cys Leu Ser Gly Ala Ala Val Leu Arg Gly Ala Thr Leu Leu Ala Pro 145 150 155 160 Leu Pro Phe Phe Leu Lys Thr Phe Pro Phe Cys Gly Thr Asn Ile Leu 165 170 175 Ser His Ser Tyr Cys Tyr Tyr Pro Asp Met Leu Asn Leu Ala Cys Gly 180 185 190 Asp Val Ser Phe Ser Ser Ala Tyr Gly Leu Val Phe Val Leu Cys Thr 195 200 205 Phe Ala Val Asp Val Val Phe Ile Ile Ala Ser Tyr Met Lys Ile Leu 210 215 220 Gly Thr Ile Met Asn Leu Glu Thr Gln Asp Arg Asn Trp Lys Ser Leu 225 230 235 240 His Thr Cys Ala Cys His Leu Cys Thr Val Leu Val Phe Tyr Leu Pro 245 250 255 Leu Ile Ser Leu Ala Val Leu His Arg Tyr Ser Arg Asp Ala Ser Pro 260 265 270 Val Leu Tyr Thr Thr Met Ser Asn Ala Tyr Leu Leu Met Thr Pro Leu 275 280 285 Leu Asn Pro Leu Val Tyr Ser Val Lys Ser Arg Gln Ile Gln Ala Ala

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290 295 300

Leu Arg Lys Arg Phe Trp Val Gln Arg Val Ile Ala Gly Glu 305 310 315 <210> 1397 <211> 921 <212> DNA <213> Canis familiaris <400> 1397

ttctatcagc cccccttctt ccttctttca ggaattccag agctagagga gtctcacatc 60 tggatctcca tcccactggg catcatgtac gtaactttca tcctgggaaa cagcatcatt 120 attcacataa tacctaagaa tcccagcctt catgagcctc aatatttgtt cttatcccta 180 ttggcagcca ctgacacagg cacatcagca tctataccaa ctactgtact taatatcttt 240 ctcttcaacc acagaaagat ggagttccat ggttgcttgg ctcctatgtt cttcatccat 300 atcttttcat atgttcttca tccatatctt ttcatggagt cagccattct gctggccatg 360 gctgttgacc cctttattgc catatgcaat tcactgcact acactgtggt cctgactcaa 420 tcccatgtta atcagatgca attggctact gtggctcgag gagaggtgct gatggcttcc 480 ttgcccatcc tgctcaaatg gcttcccttc tgtaagaaca tcatcctacc cactcattct 540 gcttcccccc tgatatggaa gcttgcttgt gggtccattc atgtgaacat cacttacagg 600 ctggcactgg atctctgctc ctttggtgtt gactccatct ttattgttct gttttatgtg 660 ttgatcaaga cagttttggg cattgtttct aggaaaggac agcttaagac agtcaacaca 720 tgtgtctccc ttaatgtcac tgtcctcatt ttctatgtcc cacttattgt cttaatcctc 780 atcctcagaa taggcaaata ccactcccct ctcccccatg tcactatgtc caacattttc 840 cttttcctca catctgtcct caaccatcta atttacagtg tgaaaacaaa acagatcaga 900 agggcactat gtagactatt t 921

<210> 1398 <211> 307 <212> PRT <213> Canis familiaris <400> 1398

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Phe 1 Tyr Gln Pro Pro 5 Phe Phe Leu Leu Ser Gly Ile Pro Glu Leu Glu 10 15 Glu Ser His Ile Trp Ile Ser Ile Pro Leu Gly Ile Met Tyr Val Thr 20 25 30 Phe Ile Leu Gly Asn Ser Ile Ile Ile His Ile Ile Pro Lys Asn Pro 35 40 45 Ser Leu His Glu Pro Gln Tyr Leu Phe Leu Ser Leu Leu Ala Ala Thr 50 55 60 Asp Thr Gly Thr Ser Ala Ser Ile Pro Thr Thr Val Leu Asn Ile Phe 65 70 75 80 Leu Phe Asn His Arg Lys Met Glu Phe His Gly Cys Leu Ala Pro Met 85 90 95 Phe Phe Ile His Ile Phe Ser Tyr Val Leu His Pro Tyr Leu Phe Met 100 105 110 Glu Ser Ala Ile Leu Leu Ala Met Ala Val Asp Pro Phe Ile Ala Ile 115 120 125 Cys Asn Ser Leu His Tyr Thr Val Val Leu Thr Gln Ser His Val Asn 130 135 140 Gln Met Gln Leu Ala Thr Val Ala Arg Gly Glu Val Leu Met Ala Ser 145 150 155 160 Leu Pro Ile Leu Leu Lys Trp Leu Pro Phe Cys Lys Asn Ile Ile Leu 165 170 175 Pro Thr His Ser Ala Ser Pro Leu Ile Trp Lys Leu Ala Cys Gly Ser 180 185 190 Ile His Val Asn Ile Thr Tyr Arg Leu Ala Leu Asp Leu Cys Ser Phe 195 200 205

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Gly Val 210 Asp Ser Ile Phe Ile 215 069269_0225_SL.TXT Val Leu Phe Tyr Val Leu 220 Ile Lys Thr Val Leu Gly Ile Val Ser Arg Lys Gly Gln Leu Lys Thr Val Asn Thr 225 230 235 240 Cys Val Ser Leu Asn Val Thr Val Leu Ile Phe Tyr Val Pro Leu Ile 245 250 255 Val Leu Ile Leu Ile Leu Arg Ile Gly Lys Tyr His Ser Pro Leu Pro 260 265 270 His Val Thr Met Ser Asn Ile Phe Leu Phe Leu Thr Ser Val Leu Asn 275 280 285 His Leu Ile Tyr Ser Val Lys Thr Lys Gln Ile Arg Arg Ala Leu Cys 290 295 300

Arg Leu Phe 305

<210> 1399 <211> 954 <212> DNA <213> Canis familiaris <400> 1399 atggaactta taaataagag ctttttccag ccacccactc tccttctaac aggcattcct 60 ggactggagg ctatacaaat atggatctct atcccattgt gtgtcatgta tctaatttct 120 ctcctgggga actgtatcat cctctttgtt atcaaaatga cctccaggct tcatgagcct 180 cagtacatct tcctatctat gctggcaacc acagatgtgg gtctgtcttt atcaactcta 240 cctacagtac tcatggtctt cctcttgaat cacagagaaa ttgagttcca ttcttgtcta 300 acacagatgt tcttcatcca taccttctcc tccatggagt cagccatcct attggccatg 360 gcctttgacc gatttgtggc tatttgcaac ccactgcact acaccatggt cttaacttct 420 cctcggatta ttgggatggg gattgcagcc atggttaggg gagtggtgtt gatggtaccc 480 ttgccaatcc tgctcaagcg attgtccttc tgcaaggatg ttattctatc acattgttac 540

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tgttatcatc ctgatgttat gaaactggcc tgtggccctg tcagagtcaa catcatctat 600 gggttgtccc ttgtcctctg ctcctttgga gttgatgctg tgttcattgt catttcatac 660 atccttattt tgaaaacagt gctggatatt gcctcagaag atggtcagct caaggcactt 720 aatacttgtg tttcccacat ttttactgtc tgcatctttt atgtgccact cattgtgctg 780 gctctaattc acaggtttgg gacattcacg tctcctcttc tccatgtcac catggccaat 840 ctctttctct tcttgacccc tgtccttaat cccttggttt atagcctgaa aaccaaacag 900 ataagatctg taatatacaa ggtattcaaa ggcaggggaa acttgttcaa gtag 954

<210> 1400 <211> 317 <212> PRT <213> Canis familiaris <400> 1400

Met Glu Leu Ile Asn Lys Ser Phe Phe Gln Pro Pro Thr Leu Leu Leu 1 5 10 15 Thr Gly Ile Pro Gly Leu Glu Ala Ile Gln Ile Trp Ile Ser Ile Pro 20 25 30 Leu Cys Val Met Tyr Leu Ile Ser Leu Leu Gly Asn Cys Ile Ile Leu 35 40 45 Phe Val Ile Lys Met Thr Ser Arg Leu His Glu Pro Gln Tyr Ile Phe 50 55 60 Leu Ser Met Leu Ala Thr Thr Asp Val Gly Leu Ser Leu Ser Thr Leu 65 70 75 80 Pro Thr Val Leu Met Val Phe Leu Leu Asn His Arg Glu Ile Glu Phe 85 90 95 His Ser Cys Leu Thr Gln Met Phe Phe Ile His Thr Phe Ser Ser Met 100 105 110 Glu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125

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Cys Asn Pro Leu His Tyr Thr Met Val Leu Thr Ser Pro Arg Ile Ile 130 135 140 Gly Met Gly Ile Ala Ala Met Val Arg Gly Val Val Leu Met Val Pro 145 150 155 160 Leu Pro Ile Leu Leu Lys Arg Leu Ser Phe Cys Lys Asp Val Ile Leu 165 170 175 Ser His Cys Tyr Cys Tyr His Pro Asp Val Met Lys Leu Ala Cys Gly 180 185 190 Pro Val Arg Val Asn Ile Ile Tyr Gly Leu Ser Leu Val Leu Cys Ser 195 200 205 Phe Gly Val Asp Ala Val Phe Ile Val Ile Ser Tyr Ile Leu Ile Leu 210 215 220 Lys Thr Val Leu Asp Ile Ala Ser Glu Asp Gly Gln Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Val Ser His Ile Phe Thr Val Cys Ile Phe Tyr Val Pro 245 250 255 Leu Ile Val Leu Ala Leu Ile His Arg Phe Gly Thr Phe Thr Ser Pro 260 265 270 Leu Leu His Val Thr Met Ala Asn Leu Phe Leu Phe Leu Thr Pro Val 275 280 285 Leu Asn Pro Leu Val Tyr Ser Leu Lys Thr Lys Gln Ile Arg Ser Val 290 295 300 Ile Tyr Lys Val Phe Lys Gly Arg Gly Asn Leu Phe Lys 305 310 315

<210> 1401 <211> 837 <212> DNA

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069269_0225_SL.TXT <213> Canis familiaris <400> 1401

cccatctgtt ccatgtacat agttgctgtt gtaggcaata ccctcttatt atttctgatc 60 ttcactgaaa cgcagtcttc atgagcccat gtgcctcttc ttgtccatgt tgtctctggc 120 agatatcttt ctctccacag tcaccacgcc aaagatgcta gcaatcttct ggttccaaga 180 tggggtattt cttttggttg ttgtgtgtcc cagaggtttt ttatacactt catctttgtg 240 gcagagtctg ccatattgct ggccatggca tttgaccact atgtagctat ttgttatcca 300 ctaagatata ctaccatttt aagcctctca atctttggaa aaatgggcat tgcatctgtg 360 attaggagtt ttttcatctg tttccctttg gtttttctgg tttatcagct tacttactgt 420 agaagaaata ttattgatca ttcatattgt gaacatttgg gcattgccag gtatgcctgt 480 gatagcatca aagtcaacat ctactatggg gtgattgtgg cactttctac atgcctggat 540 gtggtattta tcatcatttc ctatgccctt atactctgta tggtgtttag aatttcttct 600 caagatgccc aactcaaggc tctgggtgct tgtgactccc atgtctgtgt tattttactg 660 ttccatactc cagccttttt ttcattcttt gctcaccaat ttggaggcca gaatatacca 720 ctccatgtac atatcctcct tgccaatctt tatgtggtgg taccatccac tctcaaccca 780 atcatttatg gagttaagac caaggaaatt caggagaagt ttatccagat cttttct 837

<210> 1402 <211> 191 <212> PRT <213> Canis familiaris <400> 1402

Met Ala Phe Asp His Tyr Val Ala Ile Cys Tyr Pro Leu Arg Tyr Thr 1 5 10 15 Thr Ile Leu Ser Leu Ser Ile Phe Gly Lys Met Gly Ile Ala Ser Val 20 25 30 Ile Arg Ser Phe Phe Ile Cys Phe Pro Leu Val Phe Leu Val Tyr Gln 35 40 45 Leu Thr Tyr Cys Arg Arg Asn Ile Ile Asp His Ser Tyr Cys Glu His

50 55 60

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Leu Gly Ile Ala Arg Tyr Ala Cys Asp Ser Ile Lys Val Asn Ile Tyr 65 70 75 80 Tyr Gly Val Ile Val Ala Leu Ser Thr Cys Leu Asp Val Val Phe Ile 85 90 95 Ile Ile Ser Tyr Ala Leu Ile Leu Cys Met Val Phe Arg Ile Ser Ser 100 105 110 Gln Asp Ala Gln Leu Lys Ala Leu Gly Ala Cys Asp Ser His Val Cys 115 120 125 Val Ile Leu Leu Phe His Thr Pro Ala Phe Phe Ser Phe Phe Ala His 130 135 140 Gln Phe Gly Gly Gln Asn Ile Pro Leu His Val His Ile Leu Leu Ala 145 150 155 160 Asn Leu Tyr Val Val Val Pro Ser Thr Leu Asn Pro Ile Ile Tyr Gly 165 170 175 Val Lys Thr Lys Glu Ile Gln Glu Lys Phe Ile Gln Ile Phe Ser 180 185 190

<210> 1403 <211> 945 <212> DNA <213> Canis familiaris <400> 1403

atgtctccca tctctatctt gaatgtcagt agttccagat ttattctcac tggttttcct 60 ggcctcgaag ttcactatct ctggatctcc atccctttct cctccatcta tgctatggtc 120 ttcctgggaa actgcatggt gctgcatgtg atccggactg agccgagcct gcaccagccc 180 atgttctact tcctggccat gctggccctc actgacctgt gcatggggct gtccactatg 240 tacacggtac tgggggtgct gtgggggatc attcgtgaga tcagcctgga ttcctgcatt 300 gcccagtcct acttcatcca tggtctgtcc tttatggagt cctctgtcct ccttgctatg 360

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gcttttgacc gctacattgc catttgcaac ccattacgct actcttccat cctcactaat 420 gacaaaatca tgaaaatagg ggtgacaatc ttatgtagga gttctttact catacctcca 480 gttatcattc gtctaaagtt cttaaattat tgccaccccc atatcctttc tcattctttc 540 tgcctgcacc aagacttaat taggatggcc tgttcagaca tccgtttcaa cagcatttat 600 ggtctggccc tagtaatcag caacctattg ttggatgcag tgctcatact tatctcctat 660 atcatgatct tgcatgcagt cttagctatt gcatcacggg aggagagaat caaatctttg 720 cagacttgtg tatctcacat ctgtgctgtt tcagttttct acatcccaat cattggtctg 780 actatggtgc atcgctttgg gaaacacctc tcaccattgg ttcatgtcct catgggcaac 840 atctatatcc ttttcccacc cctgatgaac cccatcattt atagtatcaa gacccaacaa 900 atacgaagga gagtccagag attgttttat ctgaaaagaa tgtaa 945 <210> 1404 <211> 314 <212> PRT <213> Canis familiaris <400> 1404 Met Ser Pro Ile Ser Ile Leu Asn Val Ser Ser Ser Arg Phe Ile Leu 1 5 10 15 Thr Gly Phe Pro Gly Leu Glu Val His Tyr Leu Trp Ile Ser Ile Pro 20 25 30 Phe Ser Ser Ile Tyr Ala Met Val Phe Leu Gly Asn Cys Met Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Met 65 70 75 80 Tyr Thr Val Leu Gly Val Leu Trp Gly Ile Ile Arg Glu Ile Ser Leu 85 90 95 Asp Ser Cys Ile Ala Gln Ser Tyr Phe Ile His Gly Leu Ser Phe Met

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100

069269_0225_SL.TXT 105 110

Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ser Ser Ile Leu Thr Asn Asp Lys Ile Met 130 135 140 Lys Ile Gly Val Thr Ile Leu Cys Arg Ser Ser Leu Leu Ile Pro Pro 145 150 155 160 Val Ile Ile Arg Leu Lys Phe Leu Asn Tyr Cys His Pro His Ile Leu 165 170 175 Ser His Ser Phe Cys Leu His Gln Asp Leu Ile Arg Met Ala Cys Ser 180 185 190 Asp Ile Arg Phe Asn Ser Ile Tyr Gly Leu Ala Leu Val Ile Ser Asn 195 200 205 Leu Leu Leu Asp Ala Val Leu Ile Leu Ile Ser Tyr Ile Met Ile Leu 210 215 220 His Ala Val Leu Ala Ile Ala Ser Arg Glu Glu Arg Ile Lys Ser Leu 225 230 235 240 Gln Thr Cys Val Ser His Ile Cys Ala Val Ser Val Phe Tyr Ile Pro 245 250 255 Ile Ile Gly Leu Thr Met Val His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Leu Val His Val Leu Met Gly Asn Ile Tyr Ile Leu Phe Pro Pro Leu 275 280 285 Met Asn Pro Ile Ile Tyr Ser Ile Lys Thr Gln Gln Ile Arg Arg Arg 290 295 300

Val Gln Arg Leu Phe Tyr Leu Lys Arg Met

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305

310 <210> 1405 <211> 951 <212> DNA <213> Canis familiaris <400> 1405

atgttcaagc tcaatggcac aatcttcatg cccccggtgc tgacactgat tgggatcccc 60 agcttggagt ctgtgcagtt ctggattgga attcctttct gtgacatgta catcattgct 120 ctatttggga attccctgct cctgatcatc atcaaatcag aacgcagcct ccatgagccc 180 atgtatctct tcctggcaat gcttggagca acagacattg ctctcagcac ctgcatccta 240 ccaaaaatgc taggtatctt ctggtttcat ttgcctgaca tatactttga tgcctgtctc 300 tttcagatgt ggctaatcca caccttccaa ggcactaaat caggaattct gctggccatg 360 gccctggacc gctatgtggc catctgtgat cccctgagac atgcaaccat ctttacacac 420 aaacttctca ctcaaattgg agtgggggtg acgctcagag cagccctcct tgtagctcca 480 tgtctcatcc tcatcaaatg tcggctgaaa cacttccgga ccactgtggt ctcccattca 540 tactgtgagc acatggccat tgtgaagttg gcagcagaag acattcgagt caacaagatc 600 tgtggtctct ttgtggcctt cactctactt ggatttgaca taatcttcat caccctctcc 660 tacatccgaa tatttataac tgtcttcaat ctgcctcaga gggaagctag gctcaaagcc 720 gtcaacacct gcattgccca tatttgcgtc ttccttgagt tttatctcct tggtttcttc 780 tccttcttta cacacaggtt tgggttccat attccaccct acattcatat tcttctgtcc 840 aacctttacc tgcttgtccc tcctttgctc aatcctatag tgtatggggt gaagaccaaa 900 cagattcgag atcgagtgtc caaggttttc cactctaaag attcatcttg a 951

<210> 1406 <211> 316 <212> PRT <213> Canis familiaris <400> 1406

Met Phe Lys Leu Asn Gly Thr Ile Phe Met Pro Pro Val Leu Thr Leu 1 5 10 15

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Ile Gly Ile Pro 20 Ser Leu Glu Ser Val Gln Phe Trp Ile Gly Ile Pro 25 30 Phe Cys Asp Met Tyr Ile Ile Ala Leu Phe Gly Asn Ser Leu Leu Leu 35 40 45 Ile Ile Ile Lys Ser Glu Arg Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Gly Ala Thr Asp Ile Ala Leu Ser Thr Cys Ile Leu 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Leu Pro Asp Ile Tyr Phe 85 90 95 Asp Ala Cys Leu Phe Gln Met Trp Leu Ile His Thr Phe Gln Gly Thr 100 105 110 Lys Ser Gly Ile Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Ala Thr Ile Phe Thr His Lys Leu Leu Thr 130 135 140 Gln Ile Gly Val Gly Val Thr Leu Arg Ala Ala Leu Leu Val Ala Pro 145 150 155 160 Cys Leu Ile Leu Ile Lys Cys Arg Leu Lys His Phe Arg Thr Thr Val 165 170 175 Val Ser His Ser Tyr Cys Glu His Met Ala Ile Val Lys Leu Ala Ala 180 185 190 Glu Asp Ile Arg Val Asn Lys Ile Cys Gly Leu Phe Val Ala Phe Thr 195 200 205 Leu Leu Gly Phe Asp Ile Ile Phe Ile Thr Leu Ser Tyr Ile Arg Ile 210 215 220

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Phe Ile 225 Thr Val Phe Asn Leu Pro Gln Arg Glu Ala Arg Leu Lys Ala 230 235 240 Val Asn Thr Cys Ile Ala His Ile Cys Val Phe Leu Glu Phe Tyr Leu 245 250 255 Leu Gly Phe Phe Ser Phe Phe Thr His Arg Phe Gly Phe His Ile Pro 260 265 270 Pro Tyr Ile His Ile Leu Leu Ser Asn Leu Tyr Leu Leu Val Pro Pro 275 280 285 Leu Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 Arg Val Ser Lys Val Phe His Ser Lys Asp Ser Ser

305 310 315 <210> 1407 <211> 951 <212> DNA <213> Canis familiaris

<400> 1407 atgttcaagc tcaatggcac aatcttcatg cccccggtgc tgacactgat tgggatcccc 60 ggcttggagt ctgtgcagtt ctggattgga attcctttct gtgccatgta catcattgct 120 ctgtttggga attccttgat cttggtcatc atcaaatcag aacgcagcct ccatgagccc 180 atgtatctct tcttggcaat gcttggagca acagacattg ctctcagcac ctgcatccta 240 ccaaaaatgc taggcatctt ctggtttcat ctgcctgaca tatactttga tgcctgtctc 300 tttcagatgt ggctcataca taccttccaa ggcattgaat caggaattct gctggccatg 360 gccctggacc gctatgtggc catctgtgat cccctgagac acgcaaccat ctttacacac 420 aaacttctca ctcaaattgg agtgggagtg atgctcagag cagccctcct tggagctcca 480 tgtctcatcc tcatcaaatg tcggctgaaa cacttccgga ccactgtggt ctcccattca 540 tactgtgagc acatggccat tgtgaagttg gcagcagaag acattcgggt caacaagatc 600 tatggtctct ttgtggcttt cattatactt ggtttagaca taatttttat aacaatctcc 660

Page 1583

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tacatccgaa tatttataac tgtcttcaat ctgcctcaga gggaagctag gctcaaagcc 720 ttcaacacct gcattgccca tatttgtgtc ttccttgagt tttatctcct tggtttcttc 780 tccttcttta cacacaggtt tgggttccat attccaccct acattcatat tcttctgtcc 840 aacctttacc tgcttgtccc tcctttgctc aatcctatag tgtatggggt gaagaccaaa 900 cagattcgag atagggtgtc caagattttc cactctaaaa ttccatcttg a 951

<210> 1408 <211> 316 <212> PRT <213> Canis familiaris <400> 1408

Met 1 Phe Lys Leu Asn Gly 5 Thr Ile Phe Met Pro Pro Val Leu Thr Leu 10 15 Ile Gly Ile Pro Gly Leu Glu Ser Val Gln Phe Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ala Met Tyr Ile Ile Ala Leu Phe Gly Asn Ser Leu Ile Leu 35 40 45 Val Ile Ile Lys Ser Glu Arg Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Gly Ala Thr Asp Ile Ala Leu Ser Thr Cys Ile Leu 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Leu Pro Asp Ile Tyr Phe 85 90 95 Asp Ala Cys Leu Phe Gln Met Trp Leu Ile His Thr Phe Gln Gly Ile 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Ala Thr Ile Phe Thr His Lys Leu Leu Thr 130 135 140

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Gln Ile Gly Val Gly Val Met Leu Arg Ala Ala Leu Leu Gly Ala Pro 145 150 155 160 Cys Leu Ile Leu Ile Lys Cys Arg Leu Lys His Phe Arg Thr Thr Val 165 170 175 Val Ser His Ser Tyr Cys Glu His Met Ala Ile Val Lys Leu Ala Ala 180 185 190 Glu Asp Ile Arg Val Asn Lys Ile Tyr Gly Leu Phe Val Ala Phe Ile 195 200 205 Ile Leu Gly Leu Asp Ile Ile Phe Ile Thr Ile Ser Tyr Ile Arg Ile 210 215 220 Phe Ile Thr Val Phe Asn Leu Pro Gln Arg Glu Ala Arg Leu Lys Ala 225 230 235 240 Phe Asn Thr Cys Ile Ala His Ile Cys Val Phe Leu Glu Phe Tyr Leu 245 250 255 Leu Gly Phe Phe Ser Phe Phe Thr His Arg Phe Gly Phe His Ile Pro 260 265 270 Pro Tyr Ile His Ile Leu Leu Ser Asn Leu Tyr Leu Leu Val Pro Pro 275 280 285 Leu Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 Arg Val Ser Lys Ile Phe His Ser Lys Ile Pro Ser 305 310 315 <210> 1409 <211> 951 <212> DNA <213> Canis familiaris <400> 1409 atggccatgt cagcctccaa tatcagctca acctatccgg cactcttcat gttgatgggg 60

Page 1585

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atcccaggcc tggagcacct gcataactgg atctccattc cattctgctt tgcctatact 120 ctggccctgc taggcaactg cacccttctc ttcattattc aggctgatgc agccctccat 180 gagcccatgt acttctttct ggccatgttg gcagccattg acctggtcct ctcttctaca 240 acacttccca aaatgctggc tattttttgg ttcagagatc gggagatcag cttctatggc 300 tgtctggtcc agatgttctt tctccactcc ttctctatca tggagtcagc agtgctgctg 360 gccatggcct ttgaccgcta tgtggccatc tgcaagccat tgcactacac cacagtcctg 420 actaggcccc tgatcaccaa gattggcatg gcagctgtgg ctcgggctgt gacattaatg 480 actccgctcc cctttctgct cagatgcttc cactactgcc gaggcaccat gattgcccac 540 tgctactgtg agcatatggc tgtggtgagg ctggcctgtg gggatactcg cttcaacaat 600 atctatggca ttgctgtggc catgtttata gtggtgttgg acctgctgtt tgttatcttg 660 tcttacatct tcatccttcg ggcagtttta cagcttgcct ctcaagaggc ccgctacaag 720 gcctttggga catgtgtatc tcacataggt gccatcttag ccttttacac acctgtggtc 780 atctcctcag tcatgcatcg tgtggctcgc cgggctgccc ctcatgtcca catacttttt 840 gctaatttct atctgctctt cccgcccatg atcaatccca tcatctatgg tgtgaagacc 900 aagcagattc gtgagcgggt cttaggacta ttccaaagaa aggatgcata a 951

<210> 1410 <211> 316 <212> PRT <213> Canis familiaris

<400> 1410 Ser Asn Ile Ser Ser Thr Tyr Pro Ala Leu Phe Met 1 Ala Met Ser Ala 5 10 15 Met Leu Met Gly Ile Pro Gly Leu Glu His Leu His Asn Trp Ile Ser 20 25 30 Ile Pro Phe Cys Phe Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr 35 40 45 Leu Leu Phe Ile Ile Gln Ala Asp Ala Ala Leu His Glu Pro Met Tyr 50 55 60

Page 1586

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Phe 65 Phe Leu Ala Met Leu 70 Ala Ala Ile Asp Leu Val Leu Ser Ser Thr 75 80 Thr Leu Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile 85 90 95 Ser Phe Tyr Gly Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser 100 105 110 Ile Met Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val 115 120 125 Ala Ile Cys Lys Pro Leu His Tyr Thr Thr Val Leu Thr Arg Pro Leu 130 135 140 Ile Thr Lys Ile Gly Met Ala Ala Val Ala Arg Ala Val Thr Leu Met 145 150 155 160 Thr Pro Leu Pro Phe Leu Leu Arg Cys Phe His Tyr Cys Arg Gly Thr 165 170 175 Met Ile Ala His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala 180 185 190 Cys Gly Asp Thr Arg Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met 195 200 205 Phe Ile Val Val Leu Asp Leu Leu Phe Val Ile Leu Ser Tyr Ile Phe 210 215 220 Ile Leu Arg Ala Val Leu Gln Leu Ala Ser Gln Glu Ala Arg Tyr Lys 225 230 235 240 Ala Phe Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ala Phe Tyr 245 250 255 Thr Pro Val Val Ile Ser Ser Val Met His Arg Val Ala Arg Arg Ala 260 265 270

Page 1587

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Ala Pro His Val His Ile Leu Phe Ala Asn Phe Tyr Leu Leu Phe Pro 275 280 285 Pro Met Ile Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg 290 295 300 Glu Arg Val Leu Gly Leu Phe Gln Arg Lys Asp Ala 305 310 315

<210> 1411 <211> 951 <212> DNA <213> Canis familiaris <400> 1411

atgttcaagc tcaatggcac aatcttcatg cccccggtgc tgacactgat tgggattccc 60 ggcttggagt ctgtgcagtt ctggattgga attcctttct gtgccatgta catcattgct 120 ctgtttggga attccctgct cctggtcatc atcaaatcag aacgcagcct ccatgagccc 180 atgtatctct tcctggcaat gcttggagca acagacattg ctctcagcac ctgcatccta 240 ccaaaaatgc taggcatctt ctggtttcat ctgcctgaca tatactttga tgcctgtctc 300 tttcagatgt ggcttatcca caccttccaa tgcattgaat caggaattct gctggccatg 360 gccctggacc gctatgtggc catctgtgat cccctgagac atgcaaccat ctttacacac 420 aaacttctca ctcaaattgg agtgggagtg atgctcagag cagccctcct tggagctcca 480 tgtctcatcc tcatcaaatg tcggctgaaa cacttcggga ccactgtggt ctcccattca 540 tactgtgagc acatggccat tgtgaagttg gcagcagaag acattcgagt caacaagatc 600 tgtggtctct ttgtggcctt cactatactt ggatttgaca taatcttcat caccctctcc 660 tacatccgaa tatttataac tgtcttcaat ctgcctcaga gggaagctag gctcaaagcc 720 ttcaacacct acattgccca tatttgcgtc ttccttgagt tttatctcct tggtttcttc 780 tccttcttta cacacaggtt tgggttccat attccaccct acattcatat tcttctgtcc 840 aacctttacc tgcttgtccc tcctttgctc aatcctatag tgtatggggt gaagaccaaa 900 cagattcgag atcgagtgtc caaggttttc cactctaaag attcctcttg a 951

Page 1588

069269_0225_SL.TXT <210> 1412 <211> 316 <212> PRT <213> Canis familiaris

<400> 1412 Asn 5 Gly Thr Ile Phe Met Pro Pro Val Leu Thr Leu Met 1 Phe Lys Leu 10 15 Ile Gly Ile Pro Gly Leu Glu Ser Val Gln Phe Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ala Met Tyr Ile Ile Ala Leu Phe Gly Asn Ser Leu Leu Leu 35 40 45 Val Ile Ile Lys Ser Glu Arg Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Gly Ala Thr Asp Ile Ala Leu Ser Thr Cys Ile Leu 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Leu Pro Asp Ile Tyr Phe 85 90 95 Asp Ala Cys Leu Phe Gln Met Trp Leu Ile His Thr Phe Gln Cys Ile 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Ala Thr Ile Phe Thr His Lys Leu Leu Thr 130 135 140 Gln Ile Gly Val Gly Val Met Leu Arg Ala Ala Leu Leu Gly Ala Pro 145 150 155 160 Cys Leu Ile Leu Ile Lys Cys Arg Leu Lys His Phe Gly Thr Thr Val 165 170 175 Val Ser His Ser Tyr Cys Glu His Met Ala Ile Val Lys Leu Ala Ala

Page 1589

180

069269_0225_SL.TXT 185 190

Glu Asp Ile 195 Arg Val Asn Lys Ile Cys Gly Leu Phe Val Ala Phe Thr 200 205 Ile Leu Gly Phe Asp Ile Ile Phe Ile Thr Leu Ser Tyr Ile Arg Ile 210 215 220 Phe Ile Thr Val Phe Asn Leu Pro Gln Arg Glu Ala Arg Leu Lys Ala 225 230 235 240 Phe Asn Thr Tyr Ile Ala His Ile Cys Val Phe Leu Glu Phe Tyr Leu 245 250 255 Leu Gly Phe Phe Ser Phe Phe Thr His Arg Phe Gly Phe His Ile Pro 260 265 270 Pro Tyr Ile His Ile Leu Leu Ser Asn Leu Tyr Leu Leu Val Pro Pro 275 280 285 Leu Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 Arg Val Ser Lys Val Phe His Ser Lys Asp Ser Ser 305 310 315

<210> 1413 <211> 951 <212> DNA <213> Canis familiaris <400> 1413

atggcagaca atgctacaca tagctacatc tcatcttttt tcctggttgg tattcctggt 60 ttgcaagctt ttcactgctg gattggcatc cctgtctgcc tcctgtttgc cctggccctg 120 ctggggaaca gtgtaatcat catcaccatc aaaatagaac ccagcctcca cctgcctatg 180 tatttcttcc tttgtatgct ggcagtgaat gacatggctc ttgtctcttc cacagccccc 240 aagatgctgg gtatcttctg gttggatgct cacaagtttg actttagtat ctgtctagca 300 caaatgtatt ttatccacac attctgcata attgagtcag ccctcttggt tgccatggcc 360

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ttcgaccggt atgtagctat ttgtatccca ctgcgttata caaccatctt gacaacacca 420 attgtcacta aaatgggtct agctggtgtg atccgagcta cctttatggt tttgccctgt 480 cctcttctta ttaaaaggct accgtattac actaaatatg ttatcaatca tgcctactgt 540 gaacacatgg ctgtggtgaa gttggccagt gccaacaccc tcattaacag agcatatgga 600 atctctgtgg ccctttcagt gatggtgttg gacctagggc tcatagctac atcctatatc 660 aagatccttc aggcagtctt ccggctatct tctcagaatg cccgctctaa agctctgggc 720 acctgtgctg cccatgtctg cactctactt gtatcgtaca cacctgcact atttagtttc 780 ctaactcacc gtattggcaa gaaggtacct tcaagcattc atataatttt tgcaagtttg 840 tatcttttgg tgcctcccac agtcaatccc ctggtgtatg gtgtcaagac caaacagatt 900 cgtgaccgag tggctagtct cttcctctca aacaagatta tttctggaaa c 951

<210> 1414 <211> 317 <212> PRT <213> Canis familiaris <400> 1414

Met Ala Asp Asn Ala Thr His Ser Tyr Ile Ser Ser Phe Phe Leu Val 1 5 10 15 Gly Ile Pro Gly Leu Gln Ala Phe His Cys Trp Ile Gly Ile Pro Val 20 25 30 Cys Leu Leu Phe Ala Leu Ala Leu Leu Gly Asn Ser Val Ile Ile Ile 35 40 45 Thr Ile Lys Ile Glu Pro Ser Leu His Leu Pro Met Tyr Phe Phe Leu 50 55 60 Cys Met Leu Ala Val Asn Asp Met Ala Leu Val Ser Ser Thr Ala Pro 65 70 75 80 Lys Met Leu Gly Ile Phe Trp Leu Asp Ala His Lys Phe Asp Phe Ser 85 90 95

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Ile Cys Leu Ala Gln 100 Met Tyr Phe Ile His Thr Phe Cys Ile Ile Glu 105 110 Ser Ala Leu Leu Val Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Ile Pro Leu Arg Tyr Thr Thr Ile Leu Thr Thr Pro Ile Val Thr Lys 130 135 140 Met Gly Leu Ala Gly Val Ile Arg Ala Thr Phe Met Val Leu Pro Cys 145 150 155 160 Pro Leu Leu Ile Lys Arg Leu Pro Tyr Tyr Thr Lys Tyr Val Ile Asn 165 170 175 His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Ser Ala Asn 180 185 190 Thr Leu Ile Asn Arg Ala Tyr Gly Ile Ser Val Ala Leu Ser Val Met 195 200 205 Val Leu Asp Leu Gly Leu Ile Ala Thr Ser Tyr Ile Lys Ile Leu Gln 210 215 220 Ala Val Phe Arg Leu Ser Ser Gln Asn Ala Arg Ser Lys Ala Leu Gly 225 230 235 240 Thr Cys Ala Ala His Val Cys Thr Leu Leu Val Ser Tyr Thr Pro Ala 245 250 255 Leu Phe Ser Phe Leu Thr His Arg Ile Gly Lys Lys Val Pro Ser Ser 260 265 270 Ile His Ile Ile Phe Ala Ser Leu Tyr Leu Leu Val Pro Pro Thr Val 275 280 285 Asn Pro Leu Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp Arg Val 290 295 300

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Ala Ser Leu Phe Leu Ser Asn Lys Ile Ile Ser Gly Asn 305 310 315 <210> 1415 <211> 945 <212> DNA <213> Canis familiaris <400> 1415

atgcctgctt ttcctgctta tgacaccaat tcctccacct ttctactaac aggcttccct 60 ggcctggaac aggaatatcc ctggctgtcc atccctttct cctgtatcta tgctatggta 120 ctgtctggga actgcctggt gctgcatgtg atccggactg agccgagcct gcaccagccc 180 atgttctact tcctggccac gctggccctc actgacctgt gcatggggct gtccacggtg 240 cacacggtgc tgggcatcct gtggggactt agccaggaag tcagcctgga tgcctgcatt 300 gctcaaactt atttcatcca tggtctgtcc ctcacagagt ctggagtcct tctcgccatg 360 gctttggatc gctttacagc gatctgtaac cctctgaggt atacgtccat actaaccagt 420 gccaggatta ccaagattgg gctgggaatt ttagttagga gttttgtgtt cattatggct 480 cccataatcc gcctaaagtt tttccactat tgccattccc acatcctctc gcactctttt 540 tgccttcacc aagacttact aagactagca tgttctgaca ttcgctttaa cagtttctat 600 gccttggctc tggtgatttg cacacttttg tttgattcca tgctaattat tgtatcctac 660 attctgatcc tgcattctgt cttggctatt gcatcccggg aggagcggct taagtccttg 720 cagacctgtg tctcccatat ctgtgctgtc atggttttct atatcccaat aattggtctg 780 actatggtgc atcgttttgg gaaacacctc tctcctatgg tccatgtcct catgggcaac 840 atctatatca tcttcccacc cttgatgaac cccatcatct acagtgtcaa aacccaacaa 900 atccgtggca ggattcagaa gtggttttcc atgaaaaagg agtaa 945

<210> 1416 <211> 314 <212> PRT <213> Canis familiaris <400> 1416

Met Pro Ala Phe Pro Ala Tyr Asp Thr Asn Ser Ser Thr Phe Leu Leu 1 5 10 15

Page 1593

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Thr Gly Phe Pro 20 Gly Leu Glu Gln Glu Tyr Pro Trp Leu Ser Ile Pro 25 30 Phe Ser Cys Ile Tyr Ala Met Val Leu Ser Gly Asn Cys Leu Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Thr Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Val 65 70 75 80 His Thr Val Leu Gly Ile Leu Trp Gly Leu Ser Gln Glu Val Ser Leu 85 90 95 Asp Ala Cys Ile Ala Gln Thr Tyr Phe Ile His Gly Leu Ser Leu Thr 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Leu Asp Arg Phe Thr Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr Ser Ala Arg Ile Thr 130 135 140 Lys Ile Gly Leu Gly Ile Leu Val Arg Ser Phe Val Phe Ile Met Ala 145 150 155 160 Pro Ile Ile Arg Leu Lys Phe Phe His Tyr Cys His Ser His Ile Leu 165 170 175 Ser His Ser Phe Cys Leu His Gln Asp Leu Leu Arg Leu Ala Cys Ser 180 185 190 Asp Ile Arg Phe Asn Ser Phe Tyr Ala Leu Ala Leu Val Ile Cys Thr 195 200 205 Leu Leu Phe Asp Ser Met Leu Ile Ile Val Ser Tyr Ile Leu Ile Leu 210 215 220

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His 225 Ser Val Leu Ala Ile 230 Gln Thr Cys Val Ser 245 His Ile Ile Gly Leu 260 Thr Met Met Val His 275 Val Leu Met Met Asn 290 Pro Ile Ile Tyr Ile 305 Gln Lys Trp Phe Ser 310

Ala Ser Arg Glu Glu 235 Ile Cys Ala Val 250 Met Val His Arg 265 Phe Gly Gly Asn 280 Ile Tyr Ile Ser 295 Val Lys Thr Gln Met Lys Lys Glu

Arg Leu Lys Ser Leu 240 Val Phe Tyr Ile 255 Pro Lys His Leu 270 Ser Pro Ile Phe 285 Pro Pro Leu Gln 300 Ile Arg Gly Arg

<210> 1417 <211> 318 <212> DNA <213> Canis familiaris <400> 1417 atgtctgttc aatctgattc ggactggagc aagaatatcc ctgtctggga actgcctggt atgttctact tcctggccat tacacggtac tgggcatcct aaaacttcta tattcatg caaagtcagt aacttcacct ctggctgtcc atccctttct gctgcatgtg atccggactg gctggccctc actgacctgt gtgggggctc agccaggaga ttctacttac gggattccct cctgtatcta tgctatggta agccgagcct gcaccagccc gcatggggct gtccactatg tttggatgcc tgcattgcct

120

180

240

300

318 <210> 1418 <211> 106 <212> PRT <213> Canis familiaris <400> 1418

Met Ser Val Gln Ser Asp Ser Lys Val Ser Asn Phe Thr Phe Leu Leu 1 5 10 15

Page 1595

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Thr Gly Phe Pro 20 Gly Leu Glu Gln Glu Tyr Pro Trp Leu Ser Ile Pro 25 30 Phe Ser Cys Ile Tyr Ala Met Val Leu Ser Gly Asn Cys Leu Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Met 65 70 75 80 Tyr Thr Val Leu Gly Ile Leu Trp Gly Leu Ser Gln Glu Ile Trp Met 85 90 95 Pro Ala Leu Pro Lys Thr Ser Ile Phe Met 100 105

<210> 1419 <211> 951 <212> DNA <213> Canis familiaris <400> 1419

atgtccaagc tcaatggcac aatcttcatg cccccggtgc tgacactgat tgggatcccc 60 ggcttggagt ctgtgcagtt ctggattgga attcctttct gtgccatgta catcattgct 120 ctgtttggga attccctgct cctggtcatc atcaaatcag aacgcagcct ccatgagccc 180 atgtatctct tcctggcaat gcttggagtc acagacattg ctctcagcac ctgcatccta 240 ccaaaaatgc taggcatctt ctggtttcat ctgcctgaca tatactttga tgcctgtctc 300 tttcagatgt ggcttatcca caccttccaa tccattgaaa taggaattct gttcgccatg 360 gccctgtacc gctatgtggc catctgtgat cccctgagac acgcatccat ctttacacac 420 aaacttctca ctcagattgg agtgggagtg acactcagag cagccctcct tgtagctcca 480 tgtctcatcc tcatcaaatg tcggctgaaa cacttccgga ccactgtggt ctcccattca 540 tactgtgagc acatggccat tgtgaagttg gcagcagaag acattcgagt caacaagatc 600

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tatggtctct ttgtggcctt cactatactt ggatttgaca taatcttcat caccctctcc 660 tacatccgaa tatttataac tgtcttcaat ctgcctcaga gggaagctag gctcaaagcc 720 ttcaacacct gcattgccca tatttgcgtc ttccttgagt tttatctcct tggtttcttc 780 tccttcttta cacacaggtt tgggttccat attccaccct acattcatat tcttctgtcc 840 aacctttacc tgcttgtccc tcctttgctc aatcctatag tgtatggggt gaagaccaaa 900 cagattcgag atcgagtgtc caaggttttc cactctaaag attcatcttg a 951

<210> 1420 <211> 316 <212> PRT <213> Canis familiaris

<400> 1420 Ile Phe Met Pro Pro Val Leu Thr Leu Met Ser 1 Lys Leu Asn Gly Thr 5 10 15 Ile Gly Ile Pro Gly Leu Glu Ser Val Gln Phe Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ala Met Tyr Ile Ile Ala Leu Phe Gly Asn Ser Leu Leu Leu 35 40 45 Val Ile Ile Lys Ser Glu Arg Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Gly Val Thr Asp Ile Ala Leu Ser Thr Cys Ile Leu 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Leu Pro Asp Ile Tyr Phe 85 90 95 Asp Ala Cys Leu Phe Gln Met Trp Leu Ile His Thr Phe Gln Ser Ile 100 105 110 Glu Ile Gly Ile Leu Phe Ala Met Ala Leu Tyr Arg Tyr Val Ala Ile 115 120 125

Cys Asp

Pro Leu Arg

His Ala Ser

Ile Phe Thr His

Lys Leu Leu Thr

Page 1597

130 135 069269_0225_SL.TXT 140 Gln Ile Gly Val Gly Val Thr Leu Arg Ala Ala Leu Leu Val Ala Pro 145 150 155 160 Cys Leu Ile Leu Ile Lys Cys Arg Leu Lys His Phe Arg Thr Thr Val 165 170 175 Val Ser His Ser Tyr Cys Glu His Met Ala Ile Val Lys Leu Ala Ala 180 185 190 Glu Asp Ile Arg Val Asn Lys Ile Tyr Gly Leu Phe Val Ala Phe Thr 195 200 205 Ile Leu Gly Phe Asp Ile Ile Phe Ile Thr Leu Ser Tyr Ile Arg Ile 210 215 220 Phe Ile Thr Val Phe Asn Leu Pro Gln Arg Glu Ala Arg Leu Lys Ala 225 230 235 240 Phe Asn Thr Cys Ile Ala His Ile Cys Val Phe Leu Glu Phe Tyr Leu 245 250 255 Leu Gly Phe Phe Ser Phe Phe Thr His Arg Phe Gly Phe His Ile Pro 260 265 270 Pro Tyr Ile His Ile Leu Leu Ser Asn Leu Tyr Leu Leu Val Pro Pro 275 280 285 Leu Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 Arg Val Ser Lys Val Phe His Ser Lys Asp Ser Ser 305 310 315

<210> 1421 <211> 954 <212> DNA <213> Canis familiaris

Page 1598

069269_0225_SL.TXT <400> 1421 atggcagaca atgctacaca tagctacatc tcatcttttt tcctggttgg tattcctggt 60 ttgcaagctt ttcactgctg gattggcatc cctgtctgcc tcctgtttgc cctggccctg 120 ctggggaaca gtgtaatcat catcaccatc aaaatagaac ccagcctcca cctgcctgtg 180 tatttcttcc tttgtatgct ggcagtgaat gacatggctc ttgtctcttc cacagccccc 240 aagatgctgg gtatcttctg gttggatgct cacaagtttg actttagtat ctgtctagca 300 caaatgtatt ttatccacac attctgcata attgagtcag ccctcttggt tgccatggcc 360 ttcgaccggt atgtagctat ttgtatccca ctgcgttata caaccatctt gacaacacca 420 atggtcacta aaatgggtct agctggtgtg atccgagcta cctttatggt tttgccctgt 480 cctcttctta ttaaaaggct accgtattac actaaatatg ttatcaatca tgcctactgt 540 gaacacatgg ctgtggtgaa gttggccagt gccaacaccc tcattaacag agcatatgga 600 atctctgtgg ccctttcagt gatggtgttg gacctagggc tcatagctac atcctatatc 660 aagatccttc aggcagtctt ccggctatct tctcagaatg cccgctctaa agctctgggc 720 acctgtgctg cccatgtctg cactctactt ggattctaca cacctgcact atttagtttc 780 ctaactcacc gtattggcaa gaaggtacct tcaagcattc atataatctt tgcaagtttg 840 tatcttttgg tgcctcccac agtcaatccc ctggtgtatg gtgtcaagac caaacagatt 900 cgtgaccgtg tggtcagtct cttcctctca aacaagatta tttctggaaa ctaa 954 <210> 1422 <211> 317 <212> PRT <213> Canis familiaris <400> 1422

Met 1 Ala Asp Asn Ala Thr His Ser Tyr Ile Ser Ser Phe Phe Leu Val 5 10 15 Gly Ile Pro Gly Leu Gln Ala Phe His Cys Trp Ile Gly Ile Pro Val 20 25 30 Cys Leu Leu Phe Ala Leu Ala Leu Leu Gly Asn Ser Val Ile Ile Ile 35 40 45

Page 1599

Thr Ile 50 Lys Ile Glu Pro Ser 55 069269_0225_SL.TXT Phe Phe Leu Leu His Leu Pro Val Tyr 60 Cys Met Leu Ala Val Asn Asp Met Ala Leu Val Ser Ser Thr Ala Pro 65 70 75 80 Lys Met Leu Gly Ile Phe Trp Leu Asp Ala His Lys Phe Asp Phe Ser 85 90 95 Ile Cys Leu Ala Gln Met Tyr Phe Ile His Thr Phe Cys Ile Ile Glu 100 105 110 Ser Ala Leu Leu Val Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Ile Pro Leu Arg Tyr Thr Thr Ile Leu Thr Thr Pro Met Val Thr Lys 130 135 140 Met Gly Leu Ala Gly Val Ile Arg Ala Thr Phe Met Val Leu Pro Cys 145 150 155 160 Pro Leu Leu Ile Lys Arg Leu Pro Tyr Tyr Thr Lys Tyr Val Ile Asn 165 170 175 His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Ser Ala Asn 180 185 190 Thr Leu Ile Asn Arg Ala Tyr Gly Ile Ser Val Ala Leu Ser Val Met 195 200 205 Val Leu Asp Leu Gly Leu Ile Ala Thr Ser Tyr Ile Lys Ile Leu Gln 210 215 220 Ala Val Phe Arg Leu Ser Ser Gln Asn Ala Arg Ser Lys Ala Leu Gly 225 230 235 240 Thr Cys Ala Ala His Val Cys Thr Leu Leu Gly Phe Tyr Thr Pro Ala 245 250 255

Page 1600

Leu Phe Ser Phe 260 Leu Thr His 069269_0225_SL.TXT Pro 270 Ser Ser Arg Ile Gly Lys 265 Lys Val Ile His Ile Ile Phe Ala Ser Leu Tyr Leu Leu Val Pro Pro Thr Val 275 280 285 Asn Pro Leu Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp Arg Val 290 295 300 Val Ser Leu Phe Leu Ser Asn Lys Ile Ile Ser Gly Asn 305 310 315

<210> 1423 <211> 939 <212> DNA <213> Canis familiaris <400> 1423

atgtccatct ccaacattac aatcttcatg ccttctatgt tgacactaat agggatccca 60 ggcctagagt ctgtgcagtg ctggattggg attccattct gtgccatgta tctcattgct 120 atgattggaa attccttgct tctgttcatc atcaaatctg agcgcagact tcacgagccc 180 atgtatattt ttgtaggctt gctaggaatc acagatattg cacttgctac caccattatg 240 cccaagatgc ttggcatatt ctggtttcat gtgccacaga tttactttga ttcctgtttg 300 cttcaaatgg ggctcatcca tatgtttcag gggatagagt caggcatcct cctggccatg 360 gccctggacc gttatgtggc catctgttat ccactcagac acagtggcat cttcacccat 420 cagctggtgg cccaaatagg ggctattata acactcaggg ctgccattct agtggcccca 480 ggcctagtac tgataaagtg caagtttcaa ttttatcata caaccaccat ctcccactcc 540 tactgtgagc atatggccat tgtgaaactg gctgcagaaa atgtgcgggt caacaaaatc 600 tatggcttgt ttgtggcatt cgctgttgca gggttcgacc tcaccttcat cactttgtcc 660 tacatacaga tcttcttcac ggtttttcgt ttgccccaga aggaggcccg cttgaaagca 720 ttcaatacct gcattgccca catctgtgtc ttcctccagt tctacctcct cgccttcttc 780 tccttcttca cacataggtt tggtgctcat gtccctcctt atatccacat cctcttttct 840 agcctctact tgctggtccc cccatttctt aatccacttg tctatggtgc caagaccaag 900

Page 1601

939

069269_0225_SL.TXT cagatccgca ttcacgtggt aaagatgttc tgttcctaa <210> 1424 <211> 312 <212> PRT <213> Canis familiaris <400> 1424

Met 1 Ser Ile Ser Asn 5 Ile Thr Ile Phe Met Pro Ser Met 10 Leu Thr 15 Leu Ile Gly Ile Pro Gly Leu Glu Ser Val Gln Cys Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ala Met Tyr Leu Ile Ala Met Ile Gly Asn Ser Leu Leu Leu 35 40 45 Phe Ile Ile Lys Ser Glu Arg Arg Leu His Glu Pro Met Tyr Ile Phe 50 55 60 Val Gly Leu Leu Gly Ile Thr Asp Ile Ala Leu Ala Thr Thr Ile Met 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Val Pro Gln Ile Tyr Phe 85 90 95 Asp Ser Cys Leu Leu Gln Met Gly Leu Ile His Met Phe Gln Gly Ile 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg His Ser Gly Ile Phe Thr His Gln Leu Val Ala 130 135 140 Gln Ile Gly Ala Ile Ile Thr Leu Arg Ala Ala Ile Leu Val Ala Pro 145 150 155 160 Gly Leu Val Leu Ile Lys Cys Lys Phe Gln Phe Tyr His Thr Thr Thr 165 170 175

Page 1602

069269_0225_SL.TXT

Ile Ser His Ser 180 Tyr Cys Glu Asn Val 195 Arg Val Asn Val Ala 210 Gly Phe Asp Leu Phe 225 Phe Thr Val Phe Arg 230 Phe Asn Thr Cys Ile 245 Ala Leu Ala Phe Phe 260 Ser Phe Pro Tyr Ile 275 His Ile Leu Phe Leu 290 Asn Pro Leu Val His 305 Val Val Lys Met Phe 310

Glu His Met 185 Ala Ile Lys Ile 200 Tyr Gly Leu Thr 215 Phe Ile Thr Leu Leu Pro Gln Lys Glu 235 His Ile Cys Val 250 Phe Phe Thr His 265 Arg Phe Phe Ser 280 Ser Leu Tyr Tyr 295 Gly Ala Lys Thr Cys Ser

Val Lys Leu 190 Ala Ala Phe Val 205 Ala Phe Ala Ser 220 Tyr Ile Gln Ile Ala Arg Leu Lys Ala 240 Leu Gln Phe Tyr 255 Leu Gly Ala His 270 Val Pro Leu Leu 285 Val Pro Pro Lys 300 Gln Ile Arg Ile

<210> 1425 <211> 1095 <212> DNA <213> Canis familiaris <400> 1425 atgctcactc ccaatgcttc gggctggagt cagtgcagca gtattcggga attccctaat atgtacatat ttttggccat cccaaaatgt taggcatctt catcttcatg cccgctgtgc ttggattggg attccattct tttaggtata atcaaatatg gttgggggcc acagacattg ctggtttcat ttgccagaga taacactcac tgggattcct gtgtcatgta tttcattgct agcacagcct ccataagccc cacttagcac ctgtattctt tttcctgtgc agcctgcctt

120

180

240

300

Page 1603

069269_0225_SL.TXT

ctacaaatgt ggcttattca ctcattccag gcaattgaat caggcatcct actggcaatg 360 gccctagatc gttatgtggc catctgtgac cccttgagac acaccaccat cttctcccaa 420 caacttttga ctcacactgg agttggggtg acactcagga ctgccattct tattttttaa 480 aaagatttta tttatttatt cacgagggac acacagagag aggtagagac ataggcagag 540 ggagaaacag gctccctgag ggaagcctga tgcaggattc aatcccagga caccagatca 600 tgacctgaac agaaggtaga tccttaacca ctgagccacc caggcatccc agggctgcca 660 ttcctgtagc accatgccta gtactcctca aatgtcatct taaattctac cgaactacag 720 tcaagtccca tacttattgt gagcacatgg ccattgtgaa ggtggccact gaagagatct 780 gtccaggtca acaagatata tggtcttttt attgccttca gtatcttggg gtttgacaca 840 atcttcatca ccttgtctta tgttcaggtc tttatcactg tgtttcaatt gccccagaag 900 gaggcacgat ttaaggcctt taatacctgc attgtccaca tctgtgtctt cttacagttc 960 tacctccttg ccttcttctc cttcttcaca cataggtttg gttctcacat accactatat 1020 gttcatatca tcttgtcaaa cctttacctg ttagtccctc ctttcctcaa ccctatagtc 1080 tatggtatga agtcc 1095

<210> 1426 <211> 159 <212> PRT <213> Canis familiaris <400> 1426

Met 1 Leu Thr Pro Asn 5 Ala Ser Ile Phe Met Pro Ala Val Leu 10 Thr 15 Leu Thr Gly Ile Pro Gly Leu Glu Ser Val Gln His Trp Ile Gly Ile Pro 20 25 30 Phe Cys Val Met Tyr Phe Ile Ala Val Phe Gly Asn Ser Leu Ile Leu 35 40 45 Gly Ile Ile Lys Tyr Glu His Ser Leu His Lys Pro Met Tyr Ile Phe 50 55 60

Page 1604

Leu 65 Ala Met Leu Gly Ala 70 Thr 069269_0225_SL.TXT Asp Ile Ala Leu Ser Thr 75 Cys Ile Leu 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Leu Pro Glu Ile Ser Cys 85 90 95 Ala Ala Cys Leu Leu Gln Met Trp Leu Ile His Ser Phe Gln Ala Ile 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Thr Thr Ile Phe Ser Gln Gln Leu Leu Thr 130 135 140 His Thr Gly Val Gly Val Thr Leu Arg Thr Ala Ile Leu Ile Phe 145 150 155

<210> 1427 <211> 942 <212> DNA <213> Canis familiaris <400> 1427

atgtctgttc aatctgtttc caaagtcaat aacttcacct ttctacttac gggattccct 60 ggactggagc aagaatatcc ctggctgtcc atccctttct cctgtatcta tgctatggta 120 ctgtctggga actgcctggt gctgcatgtg atccggactg aaccgagcct gcaccagccc 180 atgttctact tcctggccat gctggccctc actgacctgt gcatggggct gtccacagtg 240 cacacggtgc tgggcatcct gtgggggctc agccaggaga taggtctgga tgcctgcatt 300 gctcaaacct tctttgttca tggtctgtca tgcatggagt ctggagtcct tcttgccatg 360 gcctttgatc gctttactgc catctgcaat cctctgaggt atacatccat cctcaccaat 420 accagaatca tcaacatggg catggccatc gtagggagga gtttcctgtt catcactgct 480 cccattgtcc gcctaaagtt cttccattac tgccgtcctc atatcctctc ccactctttc 540 tgcctgcacc aggacctact tcggctggcc tgctctgaca ttcgcttcaa cagcttctat 600 gccttagccc tggtgatctg cacactgttg ttggattcag tgctcattct catctcctac 660

Page 1605

069269_0225_SL.TXT

gtcttgatcc tgcactcagt tttgactatt gcatcccggg aggagcgctt caagtccttg 720 cagacctgtg tctcccacat ctgtgcagtg ctagttttct atatcccaat cattggtctg 780 accatggtgc accgctttgg aaagcatctg tctcctgtgg tccatgttct catgggcaac 840 atctatatcc ttttcccacc cttgatgaac cccatcatct acagtgtcaa aacccaacaa 900 atacgcagca ggttccagag atggttcacc aaacaaaact ga 942

<210> 1428 <211> 313 <212> PRT <213> Canis familiaris <400> 1428

Met Ser Val Gln 1 Ser 5 Val Ser Lys Val Asn Asn Phe Thr Phe Leu Leu 10 15 Thr Gly Phe Pro Gly Leu Glu Gln Glu Tyr Pro Trp Leu Ser Ile Pro 20 25 30 Phe Ser Cys Ile Tyr Ala Met Val Leu Ser Gly Asn Cys Leu Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Val 65 70 75 80 His Thr Val Leu Gly Ile Leu Trp Gly Leu Ser Gln Glu Ile Gly Leu 85 90 95 Asp Ala Cys Ile Ala Gln Thr Phe Phe Val His Gly Leu Ser Cys Met 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Phe Asp Arg Phe Thr Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr Asn Thr Arg Ile Ile 130 135 140

Page 1606

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Asn Met Gly 145 Met Ala Ile Val Gly Arg Ser Phe Leu Phe Ile Thr Ala 150 155 160 Pro Ile Val Arg Leu Lys Phe Phe His Tyr Cys Arg Pro His Ile Leu 165 170 175 Ser His Ser Phe Cys Leu His Gln Asp Leu Leu Arg Leu Ala Cys Ser 180 185 190 Asp Ile Arg Phe Asn Ser Phe Tyr Ala Leu Ala Leu Val Ile Cys Thr 195 200 205 Leu Leu Leu Asp Ser Val Leu Ile Leu Ile Ser Tyr Val Leu Ile Leu 210 215 220 His Ser Val Leu Thr Ile Ala Ser Arg Glu Glu Arg Phe Lys Ser Leu 225 230 235 240 Gln Thr Cys Val Ser His Ile Cys Ala Val Leu Val Phe Tyr Ile Pro 245 250 255 Ile Ile Gly Leu Thr Met Val His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Val Val His Val Leu Met Gly Asn Ile Tyr Ile Leu Phe Pro Pro Leu 275 280 285 Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Gln Gln Ile Arg Ser Arg 290 295 300 Phe Gln Arg Trp Phe Thr Lys Gln Asn 305 310 <210> 1429 <211> 951 <212> DNA <213> Canis familiaris <400> 1429 atgcctatta caaatggcac catgttcatg ccctctgtgc tgatcttcat tgggatccct 60

Page 1607

069269_0225_SL.TXT

ggtctagaaa gtatacagtg ttggattggg attccattct gtgctatgta cgtcattgct 120 ttggtgggaa attctctgct attgatcatc atcatatctg aacccagtct ccatgagcct 180 atgtatatct ttctggccat gttgggagcc acagacattg cacttagcac catctttgtc 240 cccaagatgc ttggaacttt ttggttccac ttgccagaga tcttttttga tgtttgcctc 300 tttcagatgt ggctcatcca cacatttcag ggtattgaat caggagtcct gctggctatg 360 gctctggacc gctatgtagc aatctgttac cctctgaggc atgctaccat attcactcga 420 caactagtca ctcacattgg agttgcagtg acactgcggc ctgccattct ggtcatccca 480 tgtctgttgc tcataaagtg tcgtctgaca ctttatcgaa ccaagttaat atcccacact 540 tactgtgaac acatggccgt cgtgaagctt gctgctgaag acgtttacat taataaattc 600 tatggtctcc ttggggcttt tattgttggt ggcctggact tcatgttgat tgccctctcc 660 tatgtacaaa tatttatcac tgtcttccgc ctgcctcaga aagaggcacg tcttaaagca 720 tttaatacat gtattcccca cctatgtgtc ttcttccaat tctatctcct tgcttttttt 780 tcctttttca ctcacagatc tggatcttat attccatcat acatacatat caccctgtcc 840 aacctttacc tactggttcc acctttcttc aatcctcttg tctatggggt gaagaccaaa 900 cacatccgag agaaagtagt aaaaatgttc cattgcaaag accaggtttg a 951

<210> 1430 <211> 316 <212> PRT <213> Canis familiaris

<400> 1430 Gly Thr Met Phe Met Pro Ser Val Leu Ile Phe Met 1 Pro Ile Thr Asn 5 10 15 Ile Gly Ile Pro Gly Leu Glu Ser Ile Gln Cys Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ala Met Tyr Val Ile Ala Leu Val Gly Asn Ser Leu Leu Leu 35 40 45 Ile Ile Ile Ile Ser Glu Pro Ser Leu His Glu Pro Met Tyr Ile Phe 50 55 60

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Leu 65 Ala Met Leu Gly Ala Thr Asp Ile Ala Leu Ser Thr Ile Phe Val 70 75 80 Pro Lys Met Leu Gly Thr Phe Trp Phe His Leu Pro Glu Ile Phe Phe 85 90 95 Asp Val Cys Leu Phe Gln Met Trp Leu Ile His Thr Phe Gln Gly Ile 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg His Ala Thr Ile Phe Thr Arg Gln Leu Val Thr 130 135 140 His Ile Gly Val Ala Val Thr Leu Arg Pro Ala Ile Leu Val Ile Pro 145 150 155 160 Cys Leu Leu Leu Ile Lys Cys Arg Leu Thr Leu Tyr Arg Thr Lys Leu 165 170 175 Ile Ser His Thr Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Ala 180 185 190 Glu Asp Val Tyr Ile Asn Lys Phe Tyr Gly Leu Leu Gly Ala Phe Ile 195 200 205 Val Gly Gly Leu Asp Phe Met Leu Ile Ala Leu Ser Tyr Val Gln Ile 210 215 220 Phe Ile Thr Val Phe Arg Leu Pro Gln Lys Glu Ala Arg Leu Lys Ala 225 230 235 240 Phe Asn Thr Cys Ile Pro His Leu Cys Val Phe Phe Gln Phe Tyr Leu 245 250 255 Leu Ala Phe Phe Ser Phe Phe Thr His Arg Ser Gly Ser Tyr Ile Pro 260 265 270

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Ser Tyr Ile His Ile Thr Leu Ser Asn Leu Tyr Leu Leu Val Pro Pro 275 280 285 Phe Phe Asn Pro Leu Val Tyr Gly Val Lys Thr Lys His Ile Arg Glu 290 295 300 Lys Val Val Lys Met Phe His Cys Lys Asp Gln Val 305 310 315

<210> 1431 <211> 924 <212> DNA <213> Canis familiaris <400> 1431 atgggagaag gaaaccaaac tactgtggct gaatttatct tgctgggtct ttcacaggat 60 ccaaagatcc agatcttgct gttctgtgtt ttcctgatca tttacctcct ctctatgttt 120 ggaaacctgc tcataataat ccttattcag actgactctc gacttcacac tcccatgtac 180 ttcttcctca aaaacttgtc ctttgctgac ctctgtttct ctacaagcat tgtgcctcag 240 atgttggtcc acttccttgt aaaaaggaaa agcatttcct ttgctggatg ctcactacag 300 atcattgtct tccttcttgc agggtgtaca gagtgtgcac ttctggcagt gatgtcttat 360 gaccgctatg tggctgtctg caagcccctg cattattcca ctgtcatgac ccaaaaagtt 420 tgtgtccagt ttgctatagt gtcttgggtc agtggggcat ttgtatgttc agtggacagt 480 gcatttacac tgtgtctccc ttaccaggga cagaatgtaa ttagtcatta tttttgtgaa 540 cctcctgcac tcctgaagct ggcttcagca gacacctaca aggctgagat ggccctcttt 600 tcaatgggtg tcattatcct cttagcacct ctctccctca tccttgtctc ctactggcat 660 attatctcca cagtgattca gatgcagtct gtagaaggga ggctcaaggt cttctctact 720 tgtggctccc atctcactgt tgtggttctc tactatgggt ctgggatatt tgcctatatg 780 agaccgaatt ccaagacaat gaatgaaaag gatcaggtca tctctgtgtt ctattcagtt 840 atgacttcca tgttgaaccc catcatttac agcttgagga acaaggatgt gaagggggct 900 ctcaggaacc tgtttagaag atag 924

Page 1610

069269_0225_SL.TXT <210> 1432 <211> 307 <212> PRT <213> Canis familiaris

<400> 1432 Met 1 Gly Glu Gly Asn Gln 5 Thr Thr Val Ala 10 Glu Phe Ile Leu Leu 15 Gly Leu Ser Gln Asp Pro Lys Ile Gln Ile Leu Leu Phe Cys Val Phe Leu 20 25 30 Ile Ile Tyr Leu Leu Ser Met Phe Gly Asn Leu Leu Ile Ile Ile Leu 35 40 45 Ile Gln Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Lys 50 55 60 Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln 65 70 75 80 Met Leu Val His Phe Leu Val Lys Arg Lys Ser Ile Ser Phe Ala Gly 85 90 95 Cys Ser Leu Gln Ile Ile Val Phe Leu Leu Ala Gly Cys Thr Glu Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Val Met Thr Gln Lys Val Cys Val Gln Phe 130 135 140 Ala Ile Val Ser Trp Val Ser Gly Ala Phe Val Cys Ser Val Asp Ser 145 150 155 160 Ala Phe Thr Leu Cys Leu Pro Tyr Gln Gly Gln Asn Val Ile Ser His 165 170 175 Tyr Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Ala Asp Thr

Page 1611

180

069269_0225_SL.TXT 185 190

Tyr Lys Ala Glu Met Ala Leu Phe Ser Met Gly Val Ile Ile Leu Leu 195 200 205

Ala Pro Leu Ser Leu Ile Leu Val Ser Tyr Trp His Ile Ile Ser Thr 210 215 220

Val Ile Gln Met Gln Ser Val Glu Gly Arg Leu Lys Val Phe Ser Thr 225 230 235 240

Cys Gly Ser His Leu Thr Val Val Val Leu Tyr Tyr Gly Ser Gly Ile 245 250 255

Phe Ala Tyr Met Arg Pro Asn Ser Lys Thr Met Asn Glu Lys Asp Gln 260 265 270

Val Ile Ser Val Phe Tyr Ser Val Met Thr Ser Met Leu Asn Pro Ile 275 280 285

Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Asn Leu 290 295 300

Phe Arg Arg 305 <210> 1433 <211> 957 <212> DNA <213> Canis familiaris <400> 1433

atgtcaaagg aaaatatcac ccatattcat gaattcatcc tggtgggctt ccctacttcc 60 ccttggctac aggttctgct tttcctcctc ttcctcatca cctacctgtt tgtcctattg 120 gagaatatga tcatcattct cactgtatgg gtcactgggt ccctgcacaa gcccatgtac 180 tattttctgg gcactatgtc ctttctggag acttggtatg tatctgtcac agtccctaag 240 atgttggctg gattcctact tcatcccaat accatctcct tcctgggatg catgatccaa 300 ctctattttt tcatctcact tgcctgtact gaatgtgtgc tcttggctgc catggcctat 360

Page 1612

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gaccgttacg tggctatatg ttgtcctctt cgttatccag ctatgatgac cacagaattt 420 tgtgtgcagc tgaccataag ttcctgggtg agtggtttca gcatctccat ggcaaaggta 480 tacttcattt cccaagttgc cttctgtggc aataatatct tgaatcattt tttctgtgat 540 gtttccccca tcctcaaact ggcctgcatg gacttttcta tggctgagat ggtagacttt 600 gtgctagcca ttctcatcct tgtgtttcct ctctcagcca ctgttctttc ctatggcttc 660 attgtttcta ccatcctgca cattccctca gccactgggc agcagaaggc cttctccacc 720 tgtgcctctc acctcacagt ggtgatcatc ttctatacag ctgtgatctt catgtatgtc 780 cgacctcggg ccattgcttc attcaattct aacaagttga tctcagccat atatgcagtt 840 tttactccca tgctcaaccc tattatctac tgcctgagga acaaggaagt caaagatgcc 900 atcagaaaaa ccatgtcaag tggccaagcc ctttttttga gagattcttt ttgctaa 957

<210> 1434 <211> 318 <212> PRT <213> Canis familiaris <400> 1434

Met Ser Lys Glu Asn Ile Thr His Ile His Glu Phe Ile Leu Val Gly 1 5 10 15 Phe Pro Thr Ser Pro Trp Leu Gln Val Leu Leu Phe Leu Leu Phe Leu 20 25 30 Ile Thr Tyr Leu Phe Val Leu Leu Glu Asn Met Ile Ile Ile Leu Thr 35 40 45 Val Trp Val Thr Gly Ser Leu His Lys Pro Met Tyr Tyr Phe Leu Gly 50 55 60 Thr Met Ser Phe Leu Glu Thr Trp Tyr Val Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Ala Gly Phe Leu Leu His Pro Asn Thr Ile Ser Phe Leu Gly 85 90 95

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Cys Met Ile Gln 100 Leu Tyr Phe Phe Ile Ser Leu Ala Cys Thr Glu Cys 105 110 Val Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Cys 115 120 125 Pro Leu Arg Tyr Pro Ala Met Met Thr Thr Glu Phe Cys Val Gln Leu 130 135 140 Thr Ile Ser Ser Trp Val Ser Gly Phe Ser Ile Ser Met Ala Lys Val 145 150 155 160 Tyr Phe Ile Ser Gln Val Ala Phe Cys Gly Asn Asn Ile Leu Asn His 165 170 175 Phe Phe Cys Asp Val Ser Pro Ile Leu Lys Leu Ala Cys Met Asp Phe 180 185 190 Ser Met Ala Glu Met Val Asp Phe Val Leu Ala Ile Leu Ile Leu Val 195 200 205 Phe Pro Leu Ser Ala Thr Val Leu Ser Tyr Gly Phe Ile Val Ser Thr 210 215 220 Ile Leu His Ile Pro Ser Ala Thr Gly Gln Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ile Ile Phe Tyr Thr Ala Val Ile 245 250 255 Phe Met Tyr Val Arg Pro Arg Ala Ile Ala Ser Phe Asn Ser Asn Lys 260 265 270 Leu Ile Ser Ala Ile Tyr Ala Val Phe Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Cys Leu Arg Asn Lys Glu Val Lys Asp Ala Ile Arg Lys Thr 290 295 300

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Met Ser Ser Gly Gln Ala Leu Phe Leu Arg Asp Ser Phe Cys 305 310 315 <210> 1435 <211> 945 <212> DNA <213> Canis familiaris <400> 1435

atgctggaga aaaacatcac tctggtcagt gagttcatcc tggtgggctt ccccactgcc 60 ccgtggatac aagtcctgct cttcttcctt ttccttgtgg tctacttgct ggtggtagta 120 gagaatctta tcatcatgct cactgtttgg atcactgcct ccctccataa acccaagtac 180 tatttcctga gtagcttgtc ttttctggag gtctggtatg tttccgtcac agttcccaag 240 atgctggatg gattccttct gcagagacga cacatctcct tcacaggttg catgacccag 300 ctctacttct ttatctcatt agcctgcaca gagtgtgtgc ttctggcagc catggcctat 360 gaccgctatg tggccatctg ccaccctctc caatacccaa tcattatgac cacaggctat 420 tgtgtacagc tggtggcttt ctcctatgtg agtggtttca tggtctctgt catcaaggtt 480 tatttcattt cacatgttgc cttttgtggt tccaatgtca tgaaccactt tttctgtgat 540 atctccccaa ttctcaagct ggcttgcaaa gacatgtcta cagctgagtt agtggacttt 600 gctttggcta tcatcattct tgtcttgcca ctcttcacca ctatcctttc ctatgtctac 660 attgtctcca ccattctgcg gataccctcc acccaaggaa ggaagaaagc cttctctacc 720 tgtgcatcac acctcactgt agtcataatt tattatacag ccatgatttt tatgtatgtt 780 cggcccagag ctattgcatc atttaattcc aacaaactaa tctcagctgt gtatgcagtg 840 ctcacaccaa tgctaaatcc tttcatctac tgccttagga accaggaagt taaaaatgct 900 atcaaaaaga ctatgggggt tggacagtgc ctcctgttta gctaa 945

<210> 1436 <211> 314 <212> PRT <213> Canis familiaris <400> 1436

Met Leu Glu Lys Asn Ile Thr Leu Val Ser Glu Phe Ile Leu Val Gly 1 5 10 15

Page 1615

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Phe Pro Thr Ala 20 Pro Trp Ile Gln Val Leu Leu Phe Phe Leu Phe Leu 25 30 Val Val Tyr Leu Leu Val Val Val Glu Asn Leu Ile Ile Met Leu Thr 35 40 45 Val Trp Ile Thr Ala Ser Leu His Lys Pro Lys Tyr Tyr Phe Leu Ser 50 55 60 Ser Leu Ser Phe Leu Glu Val Trp Tyr Val Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Asp Gly Phe Leu Leu Gln Arg Arg His Ile Ser Phe Thr Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Ile Ser Leu Ala Cys Thr Glu Cys 100 105 110 Val Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Gln Tyr Pro Ile Ile Met Thr Thr Gly Tyr Cys Val Gln Leu 130 135 140 Val Ala Phe Ser Tyr Val Ser Gly Phe Met Val Ser Val Ile Lys Val 145 150 155 160 Tyr Phe Ile Ser His Val Ala Phe Cys Gly Ser Asn Val Met Asn His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Ile Leu Lys Leu Ala Cys Lys Asp Met 180 185 190 Ser Thr Ala Glu Leu Val Asp Phe Ala Leu Ala Ile Ile Ile Leu Val 195 200 205 Leu Pro Leu Phe Thr Thr Ile Leu Ser Tyr Val Tyr Ile Val Ser Thr 210 215 220

Page 1616

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Ile 225 Leu Arg Ile Pro Ser Thr Gln Gly Arg Lys Lys Ala Phe Ser Thr 240 230 235 Cys Ala Ser His Leu Thr Val Val Ile Ile Tyr Tyr Thr Ala Met Ile 245 250 255 Phe Met Tyr Val Arg Pro Arg Ala Ile Ala Ser Phe Asn Ser Asn Lys 260 265 270 Leu Ile Ser Ala Val Tyr Ala Val Leu Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Cys Leu Arg Asn Gln Glu Val Lys Asn Ala Ile Lys Lys Thr 290 295 300 Met Gly Val Gly Gln Cys Leu Leu Phe Ser 305 310

<210> 1437 <211> 984 <212> DNA <213> Canis familiaris <400> 1437

atggagcaga gcaaccagag tggaagggta agtgagtttg tgttgctggg cttcccagct 60 cctgcaccac tgcgggcact tttatttgcc ctttctctgc tagcctatgt gttggtgctg 120 actgaaaata cactcatcat tgtggcaatt aggagccatc ccacccttca caaacccatg 180 tacttttttc tggcgaatat gtccttcttg gagatatggt atgttactgt cactattccg 240 aagatgttag ctggctttgt tgggtcaaaa cagagccatg gacagctaat ctcctttgag 300 ggctgcatga cacagctcta ctttttcctg ggactgggct gcactgagtg tgtccttctt 360 gctgttatgg cctatgatcg ttatgtggcc atctgtcatc ctctccacta tggtgtcatt 420 gtcagtggcc ggctgtgtgt gcagctagca actggctcct ggactggagg ctttggcatc 480 tccatggtca aagtttttct catttctcgc ctctcctact gtggacccaa catcatcaac 540 cactttttct gtgatgtctc cccattgctc aatctttcat gcactgacat gtcaacagca 600 gagcttacag actttgttct ggccattttt atcctgctgg ggccactctc tgtcactggg 660

Page 1617

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gcctcctaca tggccatcac tggtgctgta gtgcgcattc cttcagctgc tgggcgccat 720 aaagcctttt ccacctgtgc ctctcacctt actgttgtga tcatcttcta tgcagccagt 780 atcttcatct acgcccggcc aaaggcactc tcagcttttg acaccaacaa gctagtttct 840 gtactctatg ctgtcattgt accattgctt aaccctatca tttactgctt gcgcaatcaa 900 gaggtgaaga gagccctacg ccgcactctg cacctctacc agggccagga tactaagcac 960 aggaaagcta gtagaggtgg atag 984

<210> 1438 <211> 327 <212> PRT <213> Canis familiaris <400> 1438

Met Glu Gln Ser Asn Gln Ser Gly Arg Val Ser Glu Phe Val Leu Leu 1 5 10 15 Gly Phe Pro Ala Pro Ala Pro Leu Arg Ala Leu Leu Phe Ala Leu Ser 20 25 30 Leu Leu Ala Tyr Val Leu Val Leu Thr Glu Asn Thr Leu Ile Ile Val 35 40 45 Ala Ile Arg Ser His Pro Thr Leu His Lys Pro Met Tyr Phe Phe Leu 50 55 60 Ala Asn Met Ser Phe Leu Glu Ile Trp Tyr Val Thr Val Thr Ile Pro 65 70 75 80 Lys Met Leu Ala Gly Phe Val Gly Ser Lys Gln Ser His Gly Gln Leu 85 90 95 Ile Ser Phe Glu Gly Cys Met Thr Gln Leu Tyr Phe Phe Leu Gly Leu 100 105 110 Gly Cys Thr Glu Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr 115 120 125

Page 1618

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Val Ala 130 Ile Cys His Pro Leu His 135 Tyr Gly Val Ile Val Ser Gly 140 Arg Leu Cys Val Gln Leu Ala Thr Gly Ser Trp Thr Gly Gly Phe Gly Ile 145 150 155 160 Ser Met Val Lys Val Phe Leu Ile Ser Arg Leu Ser Tyr Cys Gly Pro 165 170 175 Asn Ile Ile Asn His Phe Phe Cys Asp Val Ser Pro Leu Leu Asn Leu 180 185 190 Ser Cys Thr Asp Met Ser Thr Ala Glu Leu Thr Asp Phe Val Leu Ala 195 200 205 Ile Phe Ile Leu Leu Gly Pro Leu Ser Val Thr Gly Ala Ser Tyr Met 210 215 220 Ala Ile Thr Gly Ala Val Val Arg Ile Pro Ser Ala Ala Gly Arg His 225 230 235 240 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Ile Phe 245 250 255 Tyr Ala Ala Ser Ile Phe Ile Tyr Ala Arg Pro Lys Ala Leu Ser Ala 260 265 270 Phe Asp Thr Asn Lys Leu Val Ser Val Leu Tyr Ala Val Ile Val Pro 275 280 285 Leu Leu Asn Pro Ile Ile Tyr Cys Leu Arg Asn Gln Glu Val Lys Arg 290 295 300 Ala Leu Arg Arg Thr Leu His Leu Tyr Gln Gly Gln Asp Thr Lys His 305 310 315 320 Arg Lys Ala Ser Arg Gly Gly 325

Page 1619

069269_0225_SL.TXT <210> 1439 <211> 954 <212> DNA <213> Canis familiaris <400> 1439

atggctggag gaaactggac aagagttgag gaatttatcc tcatgagctt ctcttctcta 60 cctactgaaa tacagtcgtt actcttcctg acattcctaa taatctacct ggtcaccctg 120 atgggaaaca ccctcatcat tctagttact ttggctgacc ccatgctgca cagtcccatg 180 tacttcttcc tcaggaacct gtccttcttg gagattggct tcaacctagt cattgtgccc 240 aagatgctgg ggaccctgct tgcctgggac acaaccatct cctttcttgg ctgtgccaca 300 cagatgtatt tcttcttctt ctttggagtt gatgaatgct tcctcctggc caccatggca 360 tatgaccgct atgtagccat ctgcagtccc ttgcactacc cagtcatcat gaaccaaagg 420 acacgtgcca aattggctgt cgcttcttgg tttccaggct ttcctgttgc tactgtgcag 480 accacgtggc tcttcagttt tccattctgt ggcaccaaca aggtgaacca cttcttctgt 540 gacagcccac ctgtgctgag actggtctgt gcagacacag cactgtttga aatctatgca 600 attgttggaa ccattctgtt tgtcatgaca ccttgcttgc tgatcctgtg ctcctatact 660 cgcattgctg ctgccatcct caaaattcca tcagctaaag ggaagcataa agccttctct 720 acatgctcct ctcacctcct tgttgtgtcc ctgttctatg tatctttaag cctcacttac 780 ttccggccta aatccaataa ttctcctgaa agcaaaaagc tgctgtcatt gtcctacact 840 gttgtgactc ccatgttgaa ccccatcatt tatagcctga gaaataatga agtgaagaat 900 gcctttggcc ggaccttccg taaggcttta ggccttagaa actgcatctc atag 954

<210> 1440 <211> 317 <212> PRT <213> Canis familiaris <400> 1440

Met Ala Gly Gly Asn Trp Thr Arg Val Glu Glu Phe Ile Leu Met Ser 1 5 10 15 Phe Ser Ser Leu Pro Thr Glu Ile Gln Ser Leu Leu Phe Leu Thr Phe

20 25 30

Page 1620

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Leu Ile Ile 35 Tyr Leu Val Thr Leu Met Gly Asn Thr Leu Ile Ile Leu 40 45 Val Thr Leu Ala Asp Pro Met Leu His Ser Pro Met Tyr Phe Phe Leu 50 55 60 Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile Val Pro 65 70 75 80 Lys Met Leu Gly Thr Leu Leu Ala Trp Asp Thr Thr Ile Ser Phe Leu 85 90 95 Gly Cys Ala Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Val Asp Glu 100 105 110 Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Ser Pro Leu His Tyr Pro Val Ile Met Asn Gln Arg Thr Arg Ala Lys 130 135 140 Leu Ala Val Ala Ser Trp Phe Pro Gly Phe Pro Val Ala Thr Val Gln 145 150 155 160 Thr Thr Trp Leu Phe Ser Phe Pro Phe Cys Gly Thr Asn Lys Val Asn 165 170 175 His Phe Phe Cys Asp Ser Pro Pro Val Leu Arg Leu Val Cys Ala Asp 180 185 190 Thr Ala Leu Phe Glu Ile Tyr Ala Ile Val Gly Thr Ile Leu Phe Val 195 200 205 Met Thr Pro Cys Leu Leu Ile Leu Cys Ser Tyr Thr Arg Ile Ala Ala 210 215 220 Ala Ile Leu Lys Ile Pro Ser Ala Lys Gly Lys His Lys Ala Phe Ser 225 230 235 240

Page 1621

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Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Val Ser Leu 245 250 255 Ser Leu Thr Tyr Phe Arg Pro Lys Ser Asn Asn Ser Pro Glu Ser Lys 260 265 270 Lys Leu Leu Ser Leu Ser Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285 Ile Ile Tyr Ser Leu Arg Asn Asn Glu Val Lys Asn Ala Phe Gly Arg 290 295 300 Thr Phe Arg Lys Ala Leu Gly Leu Arg Asn Cys Ile Ser 305 310 315

<210> 1441 <211> 954 <212> DNA <213> Canis familiaris <400> 1441

atggctggag gaaactggac aaaagttgag gagtttatcc tcataagctt ctcttctcta 60 cctactgaaa tacaattgtt actcttcctg acattcctaa tcatctacct ggccaccctg 120 atggggaaca ccctcatcat tctggttact ttggctgacc ccatgctgca cagtcccatg 180 tacttcttcc tcaggaactt gtccttcttg gagattggct tcaacctagt cattgtgccc 240 aagatgctgg ggaccctgct tgcctgggac acaaccatct cctttcttgg ctgtgccacg 300 cagatgtatt tctccttctt ctttggagtt gatgaatgct tcctcctggc caccatggca 360 tatgaccgct atgtagccat ctgcagtccc ttgcactacc cagtcatcat gaaccaaagg 420 acacgtgcca aattggctgt cgcttcttgg tttccaggct ttcctgttgc tactgtgcag 480 actacatggc tcttcagttt tccattctgt ggcaccaacg aggtgaacca cttcttctgt 540 gacagtccac ctgtgctgag gctggtctgt gcagacacaa cactgtttga aatctatgca 600 attgttggaa ctattctggt cgtcatgaca ccctgcttgc tgatcctgtg ctcctatact 660 cgcattgctg ctgccattct caaaattcca tcagctaaag ggaagcataa agccttctct 720 acatgctcct ctcacctcct tgttgtgtcc ctgttctatg tatctttaag cctcacctac 780

Page 1622

069269_0225_SL.TXT ttccggccta aatccaataa ttctcctgaa agcaaaaagc tgctgtcatt gtcctacact gttgtgactc ccatgttgaa ccccatcatt tatagcctga gaaataatga agtgaagaat gcccttggcc ggaccttcca caaggcttta ggccttagaa actgcattcc atag

840

900

954 <210> 1442 <211> 317 <212> PRT <213> Canis familiaris

<400> 1442 Trp Thr Lys Val Glu Glu Phe Ile Leu Ile Ser Met Ala 1 Gly Gly Asn 5 10 15 Phe Ser Ser Leu Pro Thr Glu Ile Gln Leu Leu Leu Phe Leu Thr Phe 20 25 30 Leu Ile Ile Tyr Leu Ala Thr Leu Met Gly Asn Thr Leu Ile Ile Leu 35 40 45 Val Thr Leu Ala Asp Pro Met Leu His Ser Pro Met Tyr Phe Phe Leu 50 55 60 Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile Val Pro 65 70 75 80 Lys Met Leu Gly Thr Leu Leu Ala Trp Asp Thr Thr Ile Ser Phe Leu 85 90 95 Gly Cys Ala Thr Gln Met Tyr Phe Ser Phe Phe Phe Gly Val Asp Glu 100 105 110 Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Ser Pro Leu His Tyr Pro Val Ile Met Asn Gln Arg Thr Arg Ala Lys 130 135 140 Leu Ala Val Ala Ser Trp Phe Pro Gly Phe Pro Val Ala Thr Val Gln 145 150 155 160

Page 1623

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Thr Thr Trp Leu Phe Ser Phe Pro Phe Cys Gly Thr Asn Glu Val Asn 165 170 175 His Phe Phe Cys Asp Ser Pro Pro Val Leu Arg Leu Val Cys Ala Asp 180 185 190 Thr Thr Leu Phe Glu Ile Tyr Ala Ile Val Gly Thr Ile Leu Val Val 195 200 205 Met Thr Pro Cys Leu Leu Ile Leu Cys Ser Tyr Thr Arg Ile Ala Ala 210 215 220 Ala Ile Leu Lys Ile Pro Ser Ala Lys Gly Lys His Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Val Ser Leu 245 250 255 Ser Leu Thr Tyr Phe Arg Pro Lys Ser Asn Asn Ser Pro Glu Ser Lys 260 265 270 Lys Leu Leu Ser Leu Ser Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285 Ile Ile Tyr Ser Leu Arg Asn Asn Glu Val Lys Asn Ala Leu Gly Arg 290 295 300 Thr Phe His Lys Ala Leu Gly Leu Arg Asn Cys Ile Pro

305 310 315 <210> 1443 <211> 975 <212> DNA <213> Canis familiaris <400> 1443 atgctcagtg aaatcctggg cagaagaatg acttggagaa actggacagt tgtcagtgag tttgttcttg tgagcttttc aactttgtcc tctgagattc aagctctgct ctttttcctg

120

Page 1624

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tttttgacta tttacttggt tactctaatg ggaaatgttc tcatcatcct ggtcactaca 180 gctgactctg ctctacaaaa tcccatgtac ttcttcctca ggaacttgtc cttcttggag 240 ataggcttca acttagtcat tgtgcccaag atgctggata ctctgatcat ccaggatgca 300 accatctcct tccttggctg tgccactcag atgtatttct tcttcttctt tggggctgct 360 gagtgctgtc tcttggccac tatggcatat gaccgctatg tggccatctg tgaccctttg 420 cgttacccaa tcattatgaa ccgcagagcc tgtgcccagc tagcagctgc ctcttggttc 480 tcaggatttc cagtggccac tgtgcaaacc acatggattt ttagcttccc tttttgtggc 540 cccaacagag tgaaccactt tttctgtgac agcccccctg tcattgcact ggtctgtgct 600 gatacctctc tgtttgaact ggaggctctg acagccactg tcctatttat cctcttccca 660 ttcttgctga tcctggggtc ctatgtccgc atcctctcca ctatcttcag gatgccctca 720 gctgagggaa aacgtaaggc cttctctacc tgttcctccc acctcctggt tgtctccctc 780 ttctacagca ccgccatcct cacatacttc cgaccccgat cgagtacctc tcctgagagc 840 aagaaactgc tatccctctc ctacaccgtg gtgactccca tgttgaaccc catcatttac 900 agcttaagga atagtgaagt gaaggctgca ctgaggcgag tcctccacag gaccttgggc 960 cctcagaaaa tctga 975

<210> 1444 <211> 324 <212> PRT <213> Canis familiaris <400> 1444

Met 1 Leu Ser Glu Ile 5 Leu Gly Arg Arg Met Thr Trp Arg Asn 10 Trp 15 Thr Val Val Ser Glu Phe Val Leu Val Ser Phe Ser Thr Leu Ser Ser Glu 20 25 30 Ile Gln Ala Leu Leu Phe Phe Leu Phe Leu Thr Ile Tyr Leu Val Thr 35 40 45 Leu Met Gly Asn Val Leu Ile Ile Leu Val Thr Thr Ala Asp Ser Ala 50 55 60

Page 1625

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Leu 65 Gln Asn Pro Met Tyr Phe Phe Leu Arg Asn Leu Ser Phe Leu Glu 70 75 80 Ile Gly Phe Asn Leu Val Ile Val Pro Lys Met Leu Asp Thr Leu Ile 85 90 95 Ile Gln Asp Ala Thr Ile Ser Phe Leu Gly Cys Ala Thr Gln Met Tyr 100 105 110 Phe Phe Phe Phe Phe Gly Ala Ala Glu Cys Cys Leu Leu Ala Thr Met 115 120 125 Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asp Pro Leu Arg Tyr Pro Ile 130 135 140 Ile Met Asn Arg Arg Ala Cys Ala Gln Leu Ala Ala Ala Ser Trp Phe 145 150 155 160 Ser Gly Phe Pro Val Ala Thr Val Gln Thr Thr Trp Ile Phe Ser Phe 165 170 175 Pro Phe Cys Gly Pro Asn Arg Val Asn His Phe Phe Cys Asp Ser Pro 180 185 190 Pro Val Ile Ala Leu Val Cys Ala Asp Thr Ser Leu Phe Glu Leu Glu 195 200 205 Ala Leu Thr Ala Thr Val Leu Phe Ile Leu Phe Pro Phe Leu Leu Ile 210 215 220 Leu Gly Ser Tyr Val Arg Ile Leu Ser Thr Ile Phe Arg Met Pro Ser 225 230 235 240 Ala Glu Gly Lys Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu 245 250 255 Val Val Ser Leu Phe Tyr Ser Thr Ala Ile Leu Thr Tyr Phe Arg Pro 260 265 270

Page 1626

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Arg Ser Ser Thr Ser Pro Glu Ser 280 Lys Lys Leu Leu Ser 285 Leu Ser Tyr 275 Thr Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn 290 295 300 Ser Glu Val Lys Ala Ala Leu Arg Arg Val Leu His Arg Thr Leu Gly 305 310 315 320

Pro Gln Lys Ile <210> 1445 <211> 948 <212> DNA <213> Canis familiaris <400> 1445

atgagagaag caaatcagac gaaggtgaca gagttcctcc tcctgggact ctctgatgac 60 ccccacactc agaagctcct atttatttta ttcctgggtg tctacctggt tactgtgctt 120 gcaaatctgc ttctcatgca ccttgttcag gctgactctc ggcttcacac acccatgtat 180 tttttcctct gcaacttatc tttggctgac ctctgttttt ctaccaacat cgttcctcag 240 gcgctggttc atctgctatc caggaagaaa atcatttcat tcacacgttg tgcagctcag 300 cttttactct tcctcatttt tgggggtaca cagtgtgcct tgctggcggt gatgtcctat 360 gatcgatatg tggccatttg caaccctttg cattacccta gaatcatgac ttggagggtg 420 tgtgttcagc tggctgtggg atcatggacc agcggcattc tggtgtctgt ggtagattcc 480 acttttacac taaggctacc ctaccgaggc agcaatagta ttgctcattt cttttgtgag 540 gcccctgcac tgttgatgct ggcatccaca gacacccaca cttcagagat ggccattttc 600 ctcatgggtg ttgtgattct cctcatacct gtatccctaa ttctggtatc ctatggccac 660 atcatagtga ctgtgttcag gatgaagtca gccattggta ggcgcaaggc attctctacc 720 tgtggttccc acctcatggt ggtcatcctc ttttacgggt cagcaatttt cacttacatg 780 ataccaaagt cttccaaaga acaggaaaaa ctggtgtctg tgttctatgc aatgatgaca 840 cccatgctca atcccctcat ctatagcttg aggaacaagg atgtgaaggg agctctgagg 900

Page 1627

069269_0225_SL.TXT aaagtggcca caaggaattt cccatgcagg cttgaaatct gccactga

948 <210> 1446 <211> 315 <212> PRT <213> Canis familiaris <400> 1446

Met 1 Arg Glu Ala Asn 5 Gln Thr Lys Val Thr Glu Phe Leu Leu Leu Gly 10 15 Leu Ser Asp Asp Pro His Thr Gln Lys Leu Leu Phe Ile Leu Phe Leu 20 25 30 Gly Val Tyr Leu Val Thr Val Leu Ala Asn Leu Leu Leu Met His Leu 35 40 45 Val Gln Ala Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60 Asn Leu Ser Leu Ala Asp Leu Cys Phe Ser Thr Asn Ile Val Pro Gln 65 70 75 80 Ala Leu Val His Leu Leu Ser Arg Lys Lys Ile Ile Ser Phe Thr Arg 85 90 95 Cys Ala Ala Gln Leu Leu Leu Phe Leu Ile Phe Gly Gly Thr Gln Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu His Tyr Pro Arg Ile Met Thr Trp Arg Val Cys Val Gln Leu 130 135 140 Ala Val Gly Ser Trp Thr Ser Gly Ile Leu Val Ser Val Val Asp Ser 145 150 155 160 Thr Phe Thr Leu Arg Leu Pro Tyr Arg Gly Ser Asn Ser Ile Ala His 165 170 175

Page 1628

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Phe Phe Cys Glu 180 Ala Pro Ala Leu His Thr Ser 195 Glu Met Ala Ile Phe 200 Ile Pro 210 Val Ser Leu Ile Leu 215 Val Val 225 Phe Arg Met Lys Ser 230 Ala Ile Cys Gly Ser His Leu 245 Met Val Val Phe Thr Tyr Met 260 Ile Pro Lys Ser Ser Val Phe 275 Tyr Ala Met Met Thr 280 Ser Leu 290 Arg Asn Lys Asp Val 295 Lys Arg 305 Asn Phe Pro Cys Arg 310 Leu Glu

Leu 185 Met Leu Ala Ser Thr 190 Asp Thr Leu Met Gly Val Val 205 Ile Leu Leu Ser Tyr Gly His 220 Ile Ile Val Thr Gly Arg Arg 235 Lys Ala Phe Ser Thr 240 Ile Leu 250 Phe Tyr Gly Ser Ala 255 Ile Ser 265 Lys Glu Gln Glu Lys 270 Leu Val Pro Met Leu Asn Pro 285 Leu Ile Tyr Gly Ala Leu Arg 300 Lys Val Ala Thr Ile Cys His

315 <210> 1447 <211> 948 <212> DNA <213> Canis familiaris <400> 1447 atgggagagg aaaaccaaac ctctgtggct ttgcagaccc agatcctgct gtttgttcat gggaacctgc tcatcatcat tctcatcttc ttttttctta gaaacctctc tttcacagat gagtttattt tcctgggcct ttcacaagac tttctcatca tttatctttt gactgtgctt atggactctc gacttcacac tcccatgtac ctctgtttct ctaccagcat cgtccctcaa

120

180

240

Page 1629

069269_0225_SL.TXT gtgttggtcc atttcctggt aaagaggaaa acaatttctt ttcttgggtg tatggcacag atagttgttt cccttctggc tgggtgtaca gagtgtgctc tgctggcggt gatgtcttat gactggtacg tggctgtctg caagcccctg cactactcta gcatcatgac ccaacaggtg tgtctccagt tggccatacg atcctgggcc agtggagcac ttgtgtctct gatggatacc acctttactt tccaactacc ctatcaaggg cagaacacta ttaatcacta cttttgtgaa cttcctgccc ttctgaaggt ggcttcagca gatacttaca gcacagaaat ggccatcttt gcaatgagcg tggacatcct tttagctcct gtctgcctga ttctggtttc ctactggaat attatctcca ctgtaatccc gatgcagtct ggggagggga ggcttaaggt tttctctacc tgtggttccc atctcattgt tgttgtcttc ttctttggct caggaatgtt caactacatg aagccaaact ccaagaaaat gaatgaaagg gataaaatga tctgtgtttc tgtgttctat gcagtggtga ctccaatgtt gaaccccata atttatagcc tgagaaacaa ggatgttaaa ggagctttca gaaacctagc aggaagaaag cccttttctg agagatgg <210> 1448 <211> 316 <212> PRT <213> Canis familiaris

300

360

420

480

540

600

660

720

780

840

900

948

<400> 1448 Asn Gln 5 Thr Ser Val Ala Glu Phe Ile Phe Leu Gly Met Gly 1 Glu Glu 10 15 Leu Ser Gln Asp Leu Gln Thr Gln Ile Leu Leu Phe Val His Phe Leu 20 25 30 Ile Ile Tyr Leu Leu Thr Val Leu Gly Asn Leu Leu Ile Ile Ile Leu 35 40 45 Ile Phe Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Phe Thr Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln 65 70 75 80 Val Leu Val His Phe Leu Val Lys Arg Lys Thr Ile Ser Phe Leu Gly Page 1630

069269_0225_SL.TXT

85 90 95

Cys Met Ala Gln Ile Val Val Ser Leu Leu Ala Gly Cys Thr Glu Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Trp Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Ser Ile Met Thr Gln Gln Val Cys Leu Gln Leu 130 135 140 Ala Ile Arg Ser Trp Ala Ser Gly Ala Leu Val Ser Leu Met Asp Thr 145 150 155 160 Thr Phe Thr Phe Gln Leu Pro Tyr Gln Gly Gln Asn Thr Ile Asn His 165 170 175 Tyr Phe Cys Glu Leu Pro Ala Leu Leu Lys Val Ala Ser Ala Asp Thr 180 185 190 Tyr Ser Thr Glu Met Ala Ile Phe Ala Met Ser Val Asp Ile Leu Leu 195 200 205 Ala Pro Val Cys Leu Ile Leu Val Ser Tyr Trp Asn Ile Ile Ser Thr 210 215 220 Val Ile Pro Met Gln Ser Gly Glu Gly Arg Leu Lys Val Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Val Phe Phe Phe Gly Ser Gly Met 245 250 255 Phe Asn Tyr Met Lys Pro Asn Ser Lys Lys Met Asn Glu Arg Asp Lys 260 265 270 Met Ile Cys Val Ser Val Phe Tyr Ala Val Val Thr Pro Met Leu Asn 275 280 285 Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Phe Arg

Page 1631

069269_0225_SL.TXT

290 295 300

Asn Leu Ala Gly Arg Lys Pro Phe Ser Glu Arg Trp 305 310 315 <210> 1449 <211> 954 <212> DNA <213> Canis familiaris <400> 1449

atggctggag gaaactggac aagagttgag gaatttatcc tcatgagctt ctcttctcta 60 cctactgaaa tacaattgtt actcttcctg acattcctaa tcatctacct ggtcaccctg 120 atgggaaaca ccctcatcat tctggttact ttggctgatc ccatgctgca cagtcccatg 180 tacttcttcc tcaggaactt gtccttcttg gagattggct tcaacctagt cattgtgccc 240 aagatgctgg ggaccctgct tgcctgggac acaaccatct cctttcttgg ctgtgccaca 300 cagatgtatt tcttcttctt ctttggaggt gctgaatgct tcctcctggc caccatggca 360 tatgaccgct atgtagccat ctgcagtccc ttgcactacc cagtcatcat gaaccaaaag 420 acacgtgcca aattggctgt cgcttcttgg tttccaggct ttcctgttgc taccgtgcag 480 accacgtggc tcttcagttt tccattctgt ggcaccaaca aggtgaacca cttcttctgt 540 gacagcccac ctgtgttgag gctggtctgt gcagacacag cactgtttga aatctatgca 600 attgttggaa ccattctggt cgtcatgaca ccctgcttgc tgatcctgtg ctcctatact 660 cgcattgctg ctgccatcct caaaattcca tcagctaaag ggaagcataa agccttctct 720 acatgctcct ctcacctcct tgttgtgtcc ctgttctatg tatctttaag cctcacctac 780 ttccggccta aatccaataa ttctcctgaa agcaaaaagc tgctgtcatt gtcctacact 840 gttgtgactc ccatgttgaa ccccatcatt tatagcctga gaaataatga agtgaagaat 900 gcctttagcc ggaccttccg taaggcttta ggccttagaa actgcatccc atag 954

<210> 1450 <211> 317 <212> PRT <213> Canis familiaris <400> 1450

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Met 1 Ala Gly Gly Asn 5 Trp Thr Arg Val Glu Glu Phe Ile Leu Met Ser 10 15 Phe Ser Ser Leu Pro Thr Glu Ile Gln Leu Leu Leu Phe Leu Thr Phe 20 25 30 Leu Ile Ile Tyr Leu Val Thr Leu Met Gly Asn Thr Leu Ile Ile Leu 35 40 45 Val Thr Leu Ala Asp Pro Met Leu His Ser Pro Met Tyr Phe Phe Leu 50 55 60 Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile Val Pro 65 70 75 80 Lys Met Leu Gly Thr Leu Leu Ala Trp Asp Thr Thr Ile Ser Phe Leu 85 90 95 Gly Cys Ala Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Gly Ala Glu 100 105 110 Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Ser Pro Leu His Tyr Pro Val Ile Met Asn Gln Lys Thr Arg Ala Lys 130 135 140 Leu Ala Val Ala Ser Trp Phe Pro Gly Phe Pro Val Ala Thr Val Gln 145 150 155 160 Thr Thr Trp Leu Phe Ser Phe Pro Phe Cys Gly Thr Asn Lys Val Asn 165 170 175 His Phe Phe Cys Asp Ser Pro Pro Val Leu Arg Leu Val Cys Ala Asp 180 185 190 Thr Ala Leu Phe Glu Ile Tyr Ala Ile Val Gly Thr Ile Leu Val Val 195 200 205

Page 1633

Met Thr 210 Pro Cys Leu Leu Ile 215 069269_0225_SL.TXT Leu Cys Ser Tyr Thr Arg 220 Ile Ala Ala Ala Ile Leu Lys Ile Pro Ser Ala Lys Gly Lys His Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Val Ser Leu 245 250 255 Ser Leu Thr Tyr Phe Arg Pro Lys Ser Asn Asn Ser Pro Glu Ser Lys 260 265 270 Lys Leu Leu Ser Leu Ser Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285 Ile Ile Tyr Ser Leu Arg Asn Asn Glu Val Lys Asn Ala Phe Ser Arg 290 295 300 Thr Phe Arg Lys Ala Leu Gly Leu Arg Asn Cys Ile Pro 305 310 315

<210> 1451 <211> 954 <212> DNA <213> Canis familiaris <400> 1451 atggctggag gaaactggac aagagttgag gaatttatcc tcatgagctt ctcttctcta 60 cctactgaaa tacaattgtt actcttcctg acattcctaa tcatctacct ggtcaccctg 120 atgggaaaca ctctcatcat tctggttact ttagctgacc ccatgctgca cagtcccatg 180 tacttcttcc tcaggaaact gtccttcttg gagattggct tcaacctagt cattgtgccc 240 aagatgctgg ggaccctgct tgcctgggac acaaccatct cctttcttgg ctgtgccaca 300 cagatgtatt tcttcttctt ctttggagtt gatgaatgct tcctcctggc caccatggca 360 tatgaccgct atgtagccat ctgcagtccc ttgcactacc cagtcatcat gaaccaaagg 420 acacgtgcca aattgactgt cgcttcttgg ttaccaggct ttcctgttgc tactgtgcag 480 accacgtggc tcttcagttt tccattctgt ggcaccaaca aggtgaacca cttcttctgt 540

Page 1634

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gacagcccac ctgtgctaag gctggtctgt gcagacacaa cactgtttga gatttatgca 600 attgttggaa ccattctggt catcatgaca ccctgcttgc tgatcctgtg ctcttacact 660 cgcattgctg ctgccatcct caaaattcca tcagctaaag ggaagcataa agccttctct 720 acatgctcct ctcacctcct tgttgtgtcc ctgttctatg tatctttaag cctcacctac 780 ttccggccta aatccaataa ttctcctgaa agcaaaaagc tgctgtcatt gtcctacact 840 gttgtgactc ccatgttgaa ccccatcatt tatagcctga gaaatgatga agtgaagaat 900 gcccttggcc cgactgtcca caaggcttta ggccttagaa actgcatccc atag 954

<210> 1452 <211> 317 <212> PRT <213> Canis familiaris <400> 1452

Met Ala Gly Gly Asn Trp Thr Arg Val Glu Glu Phe Ile Leu Met Ser 1 5 10 15 Phe Ser Ser Leu Pro Thr Glu Ile Gln Leu Leu Leu Phe Leu Thr Phe 20 25 30 Leu Ile Ile Tyr Leu Val Thr Leu Met Gly Asn Thr Leu Ile Ile Leu 35 40 45 Val Thr Leu Ala Asp Pro Met Leu His Ser Pro Met Tyr Phe Phe Leu 50 55 60 Arg Lys Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile Val Pro 65 70 75 80 Lys Met Leu Gly Thr Leu Leu Ala Trp Asp Thr Thr Ile Ser Phe Leu 85 90 95 Gly Cys Ala Thr Gln Met Tyr Phe Phe Phe Phe Phe Gly Val Asp Glu 100 105 110 Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125

Page 1635

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Ser Pro 130 Leu His Tyr Pro Val Ile Met Asn Gln Arg Thr Arg Ala Lys 135 140 Leu Thr Val Ala Ser Trp Leu Pro Gly Phe Pro Val Ala Thr Val Gln 145 150 155 160 Thr Thr Trp Leu Phe Ser Phe Pro Phe Cys Gly Thr Asn Lys Val Asn 165 170 175 His Phe Phe Cys Asp Ser Pro Pro Val Leu Arg Leu Val Cys Ala Asp 180 185 190 Thr Thr Leu Phe Glu Ile Tyr Ala Ile Val Gly Thr Ile Leu Val Ile 195 200 205 Met Thr Pro Cys Leu Leu Ile Leu Cys Ser Tyr Thr Arg Ile Ala Ala 210 215 220 Ala Ile Leu Lys Ile Pro Ser Ala Lys Gly Lys His Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Val Ser Leu 245 250 255 Ser Leu Thr Tyr Phe Arg Pro Lys Ser Asn Asn Ser Pro Glu Ser Lys 260 265 270 Lys Leu Leu Ser Leu Ser Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285 Ile Ile Tyr Ser Leu Arg Asn Asp Glu Val Lys Asn Ala Leu Gly Pro 290 295 300 Thr Val His Lys Ala Leu Gly Leu Arg Asn Cys Ile Pro

305 310 315 <210> 1453 <211> 951 <212> DNA

Page 1636

069269_0225_SL.TXT <213> Canis familiaris <400> 1453

atggagtact ggaactccac cttgggcagt ggctttatat tgatggggat tctgaatgac 60 agtgggtctc ctgaactgct ctgtgccaca atcactgtcc tatacatgtt ggctctgacc 120 agcaatggcc tgctgctctt ggtcatcaca gtggattccc ggctccatgt gcccatgtac 180 ttcctgctcg gccagctctc actcatggac ctcctcttca catctgttgt cactcccaag 240 gccctcgtgg atattctgca gagtgaaaac acgatctcct ttggaggctg tgcccttcag 300 atgtttctgg cattgacgct gggtggtgca gaggacttgc tgctggcctt catggcctat 360 gacagatatg tggccatatg tcatcctctg aactacatgg ttttcatgag gccaagggtc 420 tgctcactca tggtggccac ggcctggatc ctggcatttc tgagtgctct aggccatacc 480 ttgtatacca tgcactaccc tttctgtaaa gttcggaaga tcaggcacct gctctgtgag 540 atccctcctt tgctgaagtt ggcctgtgca gatacctccc gatatgaact cttggtgtat 600 gtgacaggag tgactttcct tttgatgcct ctttctgcca ttgttgcctc ctatgtacta 660 attctgtgta ctgtgcttca catgccctca aatgagggga agcagaaagc cctagtcacc 720 tgcttctccc acctgacagt cgttgggatt ttctatggag ctgccacatt catgtatgtc 780 ctgcccagtt ccctccacag ccccaggcag gacaacatca tctctctttt ctacacggtt 840 gtcactccag cgctgaaccc ccttatctat agcctgagga atcaggaggt catgggggcc 900 ttgagaaggg tcctgggaaa atatatgttg ccaacacact gtaccttcta a 951

<210> 1454 <211> 316 <212> PRT <213> Canis familiaris

<400> 1454 Met Glu Tyr Trp Asn Ser Thr Leu Gly Ser Gly Phe Ile Leu Met Gly 1 5 10 15

Ile Leu Asn Asp Ser Gly Ser Pro Glu Leu Leu Cys Ala Thr Ile Thr 20 25 30

Val Leu Tyr Met Leu Ala Leu Thr Ser Asn Gly Leu Leu Leu Leu Val 35 40 45

Page 1637

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Ile Thr 50 Val Asp Ser Arg Leu His 55 Val Pro Met Tyr Phe Leu Leu 60 Gly Gln Leu Ser Leu Met Asp Leu Leu Phe Thr Ser Val Val Thr Pro Lys 65 70 75 80 Ala Leu Val Asp Ile Leu Gln Ser Glu Asn Thr Ile Ser Phe Gly Gly 85 90 95 Cys Ala Leu Gln Met Phe Leu Ala Leu Thr Leu Gly Gly Ala Glu Asp 100 105 110 Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Asn Tyr Met Val Phe Met Arg Pro Arg Val Cys Ser Leu Met 130 135 140 Val Ala Thr Ala Trp Ile Leu Ala Phe Leu Ser Ala Leu Gly His Thr 145 150 155 160 Leu Tyr Thr Met His Tyr Pro Phe Cys Lys Val Arg Lys Ile Arg His 165 170 175 Leu Leu Cys Glu Ile Pro Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr 180 185 190 Ser Arg Tyr Glu Leu Leu Val Tyr Val Thr Gly Val Thr Phe Leu Leu 195 200 205 Met Pro Leu Ser Ala Ile Val Ala Ser Tyr Val Leu Ile Leu Cys Thr 210 215 220 Val Leu His Met Pro Ser Asn Glu Gly Lys Gln Lys Ala Leu Val Thr 225 230 235 240 Cys Phe Ser His Leu Thr Val Val Gly Ile Phe Tyr Gly Ala Ala Thr 245 250 255

Page 1638

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Phe Met Tyr Val Leu Pro Ser Ser Leu 265 His Ser Pro Arg Gln 270 Asp Asn 260 Ile Ile Ser Leu Phe Tyr Thr Val Val Thr Pro Ala Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Val Met Gly Ala Leu Arg Arg Val 290 295 300 Leu Gly Lys Tyr Met Leu Pro Thr His Cys Thr Phe 305 310 315

<210> 1455 <211> 972 <212> DNA <213> Canis familiaris <400> 1455

atgtccagtg aaatcctggg cagaagaatg acgtggggaa actggacgat tgtcagtgag 60 tttgttcctg tgagcttttt aactttgtcc tttgagctcc acgctctgct ctttctcttt 120 tttttttttt ttttttttga ctatttactt ggttactcta atgggcaatg ttatcattct 180 ggtcactaca gctgactccg ctctacaaaa tcctatgtac tgcttcctca ggaacttgtc 240 cttcttggag ataggcttca acttagtcat tgtgcccaag atgctggata ctctgatcat 300 ccaagacgca accatctcct tccttggctt gccactcaga tgtatttctt cttcttcgtt 360 ggggctgctg agtgctgtct cctggccaca atggcatatg accgctatgt ggccatctgt 420 gaccctttgc gttacccagt cattatgaat cacagagcct gtgcccagct agcagctgcc 480 tcttggttct caggattacc agtggccact gtgcaaacca catgggtttt tagcttccct 540 ttttgtgccc ccaacagagt gaaccacttt ttctgtgaca gcccccctgt cattgcactg 600 gtctgtgctg attcctctct gaactggagg ctctgacacc cactgtccta tttatcctct 660 tccttttctt gctgatccta gagtactatg tccgcatcct ctccattttc aggatgccct 720 cagctgaggg gaaacgtaag gccttctcta cctgttcctc ccacctcctg gttgtctccc 780 tcttctacag cactgccatc ttcacatact tcctatccct atccaacacc tctcctgacc 840

Page 1639

069269_0225_SL.TXT aagagactgc tgtccctttc ctacaccgtg gtgactctca tgttgaagcc aatcatctac agtttaagga atagtgaagt gaaggctaca ctgaggcaag tcctccacag gactctgggc cctcagaaac tc <210> 1456 <211> 95 <212> PRT

900

960

972

<213> Canis familiaris <400> 1456 Met Ser Ala Ser Ser Pro Phe Ser Gly Cys Pro Gln Leu Arg Gly Asn 1 5 10 15 Val Arg Pro Ser Leu Pro Val Pro 20 Pro Thr Ser 25 Trp Leu Ser 30 Pro Ser Ser Thr Ala 35 Leu Pro Ser Ser His 40 Thr Ser Tyr Pro Tyr Pro 45 Thr Pro Leu Leu Thr 50 Lys Arg Leu Leu Ser 55 Leu Ser Tyr Thr Val Val 60 Thr Leu Met Leu Lys Pro Ile Ile Tyr Ser Leu Arg Asn Ser Glu Val Lys Ala 65 70 75 80 Thr Leu Arg <210> 1457 <211> 861 <212> DNA <213> Canis Gln Val Leu His Arg 85 familiaris Thr Leu Gly 90 Pro Gln Lys Leu 95 <400> 1457 atgagagcag caaatcagac gcaggtgaca gagttcctcc tcctgggact ctctgatgac ccccacactc agaagctcct atttatttta ttcctgggtg tctacctggt tactgtgctt gcaaatctgc ttctcatgca ccttgttcag gctgactctc ggcttcacaa acccatgtat tttttcctct gcaacttatc tttggctgac ctctgttttt ctaccaacat cgttcctcag gccctggtcc atctgctatc caggaaaaag ataatttcat tcacatgatg tgcagctcag

120

180

240

300

Page 1640

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cttttactct tcctcatttt tgggggtaca cagtgtgcct ttctggcggt gatgtcctat 360 gatcgatatg tggccatctg caaccatttg cattactcta gcatcatgac ttggtgggtg 420 tgtattcagc tggctgcagg atcatggacc agtggcattt tggtgtctgt ggtagatacc 480 acttttatgc taaggctacc ctatcaagac agcaatagca ttgctcattt cttttgtgag 540 gcccctgcac tgttgatgct ggcatccaca gacacccaca cttcagagat ggccattttc 600 ctcatgggtg ttgtgattct cctcatacct gtatccctaa ttctggtatc ctatggccac 660 atcatagtga ttgtattcag gatgaagtca gccattggta ggtgcaagga attctctacc 720 tgtggttccc acctcatggt ggtcttcctc ttttatgggc cagcaatttt cacttacatg 780 accccaaagt gttccaaaga acaggaaaaa cttgtgtctg tgttctatgc aatggtgaca 840 cccacagtca atcctcttat c 861

<210> 1458 <211> 170 <212> PRT <213> Canis familiaris <400> 1458

Met Ser 1 Tyr Asp Arg 5 Tyr Val Ala Ile Cys Asn His 10 Leu His Tyr 15 Ser Ser Ile Met Thr Trp Trp Val Cys Ile Gln Leu Ala Ala Gly Ser Trp 20 25 30 Thr Ser Gly Ile Leu Val Ser Val Val Asp Thr Thr Phe Met Leu Arg 35 40 45 Leu Pro Tyr Gln Asp Ser Asn Ser Ile Ala His Phe Phe Cys Glu Ala 50 55 60 Pro Ala Leu Leu Met Leu Ala Ser Thr Asp Thr His Thr Ser Glu Met 65 70 75 80 Ala Ile Phe Leu Met Gly Val Val Ile Leu Leu Ile Pro Val Ser Leu 85 90 95

Page 1641

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Ile Leu Val Ser Tyr 100 Gly His Ile Ile Val 105 Ile Val Phe Arg 110 Met Lys Ser Ala Ile Gly Arg Cys Lys Glu Phe Ser Thr Cys Gly Ser His Leu 115 120 125 Met Val Val Phe Leu Phe Tyr Gly Pro Ala Ile Phe Thr Tyr Met Thr 130 135 140 Pro Lys Cys Ser Lys Glu Gln Glu Lys Leu Val Ser Val Phe Tyr Ala 145 150 155 160 Met Val Thr Pro Thr Val Asn Pro Leu Ile 165 170

<210> 1459 <211> 945 <212> DNA <213> Canis familiaris <400> 1459

atgggaaagg aaaaccaaac ctttgtgact gaatttattt tactgggcct ttcacaagac 60 ttgcagaccc agatcctgct gtttgttctt ttcctcatca tttatctttt gactgtgctt 120 gggaacctgc tcatcatcat tctcatcttc atggactctc gacttcacac tcccatgtac 180 ttttttctta gaaacctctc tttcgcagat ctctgtttct ctactagcat cgtccctcaa 240 gtgttgttcc atttcctggt aaagaggaaa acaatttctt ttcttgggtg tatgacgcag 300 attgttgtct tccttctggc tggatgtaca gagtgtgcac tgctggcggt gatgtcttat 360 gaccggtacg tggctgtctg caagcccctg cactactcta gcatcatgac ccaaaaggtg 420 tgtcttcagt tggccatagg atcctgggcc agtggagcac tcgtgtctct ggtggataac 480 acctttactt tccaactacc ctatcaagga cagaacatta ttaatcacta cttttgtgaa 540 cttcctgccc ttctgaaggt ggcttcagca gatacttaca gcacagaaat ggccatcttt 600 gcaatgggtg tagtcatgct cttagttcct gtctgcctga ttctggtctc ctactggaat 660 attatctcca ctgtgatcca gatgcagtct ggggaaggga ggctaaaggc cttctctacc 720 tgtggctccc atctcattgt tgttgtcctc ttctatggct caggaatatt cgactacatg 780

Page 1642

069269_0225_SL.TXT aggccaaact ccaagaccac aaaagagcag gataaaatgg tatctgtgtt ctatacagtg gtgactccaa tgttgaaccc cataatatat agcctgagaa acaaggatgt taaaggggct ctcagaaaac tagctggaag aaagtccttt tctcagaggc agtga

840

900

945 <210> 1460 <211> 314 <212> PRT <213> Canis familiaris <400> 1460

Met Gly 1 Lys Glu Asn Gln Thr Phe Val Thr Glu Phe Ile Leu Leu Gly 5 10 15 Leu Ser Gln Asp Leu Gln Thr Gln Ile Leu Leu Phe Val Leu Phe Leu 20 25 30 Ile Ile Tyr Leu Leu Thr Val Leu Gly Asn Leu Leu Ile Ile Ile Leu 35 40 45 Ile Phe Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln 65 70 75 80 Val Leu Phe His Phe Leu Val Lys Arg Lys Thr Ile Ser Phe Leu Gly 85 90 95 Cys Met Thr Gln Ile Val Val Phe Leu Leu Ala Gly Cys Thr Glu Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Ser Ile Met Thr Gln Lys Val Cys Leu Gln Leu 130 135 140 Ala Ile Gly Ser Trp Ala Ser Gly Ala Leu Val Ser Leu Val Asp Asn 145 150 155 160

Page 1643

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Thr Phe Thr Phe Gln Leu Pro Tyr Gln Gly Gln Asn Ile Ile Asn His 165 170 175 Tyr Phe Cys Glu Leu Pro Ala Leu Leu Lys Val Ala Ser Ala Asp Thr 180 185 190 Tyr Ser Thr Glu Met Ala Ile Phe Ala Met Gly Val Val Met Leu Leu 195 200 205 Val Pro Val Cys Leu Ile Leu Val Ser Tyr Trp Asn Ile Ile Ser Thr 210 215 220 Val Ile Gln Met Gln Ser Gly Glu Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Val Leu Phe Tyr Gly Ser Gly Ile 245 250 255 Phe Asp Tyr Met Arg Pro Asn Ser Lys Thr Thr Lys Glu Gln Asp Lys 260 265 270 Met Val Ser Val Phe Tyr Thr Val Val Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Lys Leu 290 295 300 Ala Gly Arg Lys Ser Phe Ser Gln Arg Gln 305 310 <210> 1461 <211> 945 <212> DNA <213> Canis familiaris <400> 1461 atgggagagg aaaatcaaac ctctgtggct gagtttattt tcctgggtct ttcccaggat ttgcagaccc agatcctgat gtttgttctt tttctcatca tttatctttt gactgtactt gggaacctgc tcatcatcat tctcatcttc atggactctc gacttcacac tcccatgtac

120

180

Page 1644

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ttttttctta gaaacctctc tttcgcagat ctctgtcttt ctagcagcat cgtccctcaa 240 gtgttgttcc atttcctggc aaagaggaaa gctatttctt ttcttgggtg tatgacacag 300 atagttgtct ctcttatgat tgggtgtgca gagtgtgcac tgctggcggt gatgtcttat 360 gaccggtacg tggctgtctg caagcccctg cactactcta gcatcatgac ccaaaaggtg 420 tgtctccagt tggccatagg atcctgggcc agtggagcac tcatgtctct ggtggatacc 480 acctttactt tccaactacc ctaccaagga cagaagatta ttaatcacta cttttgtgaa 540 cttcctgccc ttctgaaggt ggcttcagga gatacttaca gcacagaaat ggccgtcttt 600 gcagtgggtg tggtcatgct cttagttcct gtctgcctga ttctggtctc ctactggaat 660 attatctcca ctgtgatcca gatgcagtct ggggagggga ggctcaaggc tttctctacc 720 tgtggttccc atctcattgt tgttgtcctc ttctatggat cagcgatatt caactacatg 780 aagccaaact ccaaaatagt caatgaaagt gataaagtga tctctacatt ctatgcagtg 840 gtgactccaa tattgaaccc cataatttat agcctgagaa ataaggatgt taaagatggt 900 ttcagaaaac tagctggaag aaagctcttt tctgagagat ggtga 945

<210> 1462 <211> 314 <212> PRT <213> Canis familiaris

<400> 1462 Met Gly Glu Glu 1 Asn 5 Gln Thr Ser Val Ala Glu Phe Ile Phe Leu Gly 10 15 Leu Ser Gln Asp Leu Gln Thr Gln Ile Leu Met Phe Val Leu Phe Leu 20 25 30 Ile Ile Tyr Leu Leu Thr Val Leu Gly Asn Leu Leu Ile Ile Ile Leu 35 40 45 Ile Phe Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Phe Ala Asp Leu Cys Leu Ser Ser Ser Ile Val Pro Gln 65 70 75 80

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Val Leu Phe His Phe 85 Leu Ala Lys Arg Lys Ala Ile Ser Phe Leu Gly 90 95 Cys Met Thr Gln Ile Val Val Ser Leu Met Ile Gly Cys Ala Glu Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Ser Ile Met Thr Gln Lys Val Cys Leu Gln Leu 130 135 140 Ala Ile Gly Ser Trp Ala Ser Gly Ala Leu Met Ser Leu Val Asp Thr 145 150 155 160 Thr Phe Thr Phe Gln Leu Pro Tyr Gln Gly Gln Lys Ile Ile Asn His 165 170 175 Tyr Phe Cys Glu Leu Pro Ala Leu Leu Lys Val Ala Ser Gly Asp Thr 180 185 190 Tyr Ser Thr Glu Met Ala Val Phe Ala Val Gly Val Val Met Leu Leu 195 200 205 Val Pro Val Cys Leu Ile Leu Val Ser Tyr Trp Asn Ile Ile Ser Thr 210 215 220 Val Ile Gln Met Gln Ser Gly Glu Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Val Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Phe Asn Tyr Met Lys Pro Asn Ser Lys Ile Val Asn Glu Ser Asp Lys 260 265 270 Val Ile Ser Thr Phe Tyr Ala Val Val Thr Pro Ile Leu Asn Pro Ile 275 280 285

Page 1646

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Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Gly Phe Arg Lys Leu 290 295 300

Ala Gly Arg Lys Leu Phe Ser Glu Arg Trp

305 310 <210> 1463 <211> 945 <212> DNA <213> Canis familiaris <400> 1463

atggaagagg aaaaccaaac cactgtggct gagtttattt tcctgggcct ttcacaggac 60 ttgcagactc agatcctgct gtttgttctt tttctcatca tttatctttt gactgtgctt 120 gggaacctgc tcatcatcat tctcatcttc atggactctc gacttcacac tcccatgtac 180 ttttttctta gaaacctctc ttttgcagat ctctgtttct ctaccagcat cgtccctcaa 240 gtcttggtcc atttcctggc aaagaagaaa atgatttctt ttcttgggtg tatggcacag 300 atagttgtct cccttctgat tgggtgtaca gagtgtgcac tgctggcggt gatgtcttat 360 gaccggtacg tggctgtctg caagcccctg cactactcta gcatcatgac ccaaaaggtg 420 tgtctccagt tggccatagg atcctgggcc agtggagcac tcgtgtctct ggtggatacc 480 acctttactt tccaactacc ctatcaaggg cagaacatta ttaatcacta cttttgtgaa 540 cttcctgccc ttctgaaggt ggcttcagca gatacttaca gcacagaaat ggccatcttt 600 gcaatgggtg tggtcatcct cttagctcct gtctgcctga ttctggtctc ctactggaat 660 attatctcca ccgtgatccc gatgcagtct ggggagggga ggctcaaagc tttctctacc 720 tgtggctccc atctcattgt tgttgtcctc ttctatggat cagcaatatt caactacatg 780 aagccaaact ccaaaataat gaatgaaagg gataaagtag tctctgtgtt ctatgcagtg 840 gtgactccaa tgttgaaccc cataatttat agcctgagaa ataaagatgt taaagagggt 900 ctcagaaaac tagctggaag aaagcccttt tctcagagat ggtga 945

<210> 1464 <211> 314 <212> PRT

Page 1647

069269_0225_SL.TXT <213> Canis familiaris <400> 1464

Met Glu Glu Glu Asn Gln Thr Thr Val Ala Glu Phe Ile Phe Leu Gly 1 5 10 15 Leu Ser Gln Asp Leu Gln Thr Gln Ile Leu Leu Phe Val Leu Phe Leu 20 25 30 Ile Ile Tyr Leu Leu Thr Val Leu Gly Asn Leu Leu Ile Ile Ile Leu 35 40 45 Ile Phe Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln 65 70 75 80 Val Leu Val His Phe Leu Ala Lys Lys Lys Met Ile Ser Phe Leu Gly 85 90 95 Cys Met Ala Gln Ile Val Val Ser Leu Leu Ile Gly Cys Thr Glu Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Ser Ile Met Thr Gln Lys Val Cys Leu Gln Leu 130 135 140 Ala Ile Gly Ser Trp Ala Ser Gly Ala Leu Val Ser Leu Val Asp Thr 145 150 155 160 Thr Phe Thr Phe Gln Leu Pro Tyr Gln Gly Gln Asn Ile Ile Asn His 165 170 175 Tyr Phe Cys Glu Leu Pro Ala Leu Leu Lys Val Ala Ser Ala Asp Thr 180 185 190 Tyr Ser Thr Glu Met Ala Ile Phe Ala Met Gly Val Val Ile Leu Leu

Page 1648

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Ala 195 200 Ser Tyr Trp 205 Ser Thr Pro Val 210 Cys Leu Ile Leu 215 Val Asn 220 Ile Ile Val Ile Pro Met Gln Ser Gly Glu Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Val Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Phe Asn Tyr Met Lys Pro Asn Ser Lys Ile Met Asn Glu Arg Asp Lys 260 265 270 Val Val Ser Val Phe Tyr Ala Val Val Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Gly Leu Arg Lys Leu 290 295 300 Ala Gly Arg Lys Pro Phe Ser Gln Arg Trp 305 310

<210> 1465 <211> 858 <212> DNA <213> Canis familiaris <400> 1465

atgcctgggg aattcctgag cagaaaaatg acatgggaaa actggacagt tgacagtgaa 60 tttgtttctg tgaacttttc agccttgtcc tctgagctcc aagctctact ctttctcctt 120 ttttggacta tttactggca ccgtagtggg caatgttctt atcatcctgc tctgctctac 180 aaagtcttac ctgcttcttc cccaggaatt ttttaccacc tggaggtagg ttttaacttg 240 attattgtgc cctagatgca gcgactctga tcatccaaga tacaaccaac tccttccatg 300 gctatgccac tcagtgtatt tcttcttctt tggggctgct gagtgctgcc tcctggccac 360 aatgacatat gaccgctgtg tggccaactg tgaccctttg cgttacccag tcattatgaa 420 ctgcagagcc tgtgcccagc tagcaggtac atcttggttc tcagagtttc ctgtggccct 480

Page 1649

069269_0225_SL.TXT

gtgcaaacca catggatttt ccacttccct ttttgtgacc ccaacagagt gaaccacttt 540 ttctgtgaca gcccccctgt cattgcactg gtctgtgctg atacctctct gtttgaactg 600 gaggctctga cagccactgt cttatttatc ctcttccctt tcctgctgat cctagggtcc 660 tatgtccaca tcctctctac tatcttcagg atgccctcag ctgaggggaa acctaaggcc 720 ttttccacct attcctccca cctccttgtt gtctccctct tctacagcac cgccatcctc 780 acgtacttca atccaccacc tctcctgaga tagcctaaca ctaacacttc tccacgtcac 840 caccacccca ttagcctg 858

<210> 1466 <211> 84 <212> PRT <213> Canis familiaris

<400> 1466 Met Pro Gly Glu 1 Phe 5 Leu Ser Arg Lys Met Thr Trp Glu Asn Trp Thr 10 15 Val Asp Ser Glu Phe Val Ser Val Asn Phe Ser Ala Leu Ser Ser Glu 20 25 30 Leu Gln Ala Leu Leu Phe Leu Leu Phe Trp Thr Ile Tyr Trp His Arg 35 40 45 Ser Gly Gln Cys Ser Tyr His Pro Ala Leu Leu Tyr Lys Val Leu Pro 50 55 60 Ala Ser Ser Pro Gly Ile Phe Tyr His Leu Glu Val Gly Phe Asn Leu 65 70 75 80

Ile Ile Val Pro <210> 1467 <211> 948 <212> DNA <213> Canis familiaris <400> 1467

Page 1650

069269_0225_SL.TXT

atgagagcag caaatcagac gcaggtgaca gagttcctcc tcctgggact ctctgatgac 60 ccccacactc agaagctcct atttatttta ttcctgggtg tctacctggt tactgtgctt 120 gcaaatctgc ttctcatgcg ccttgttcag gctgactctc ggcttcacac acctatgtat 180 tttttcctct gcaacttatc tttggctgac ctctgttttt ctaccaacat tgttcctcag 240 gcgctggttc atctgctatc caggaaaaag atcatttcat tcacacgttg tgcagctcag 300 cttttactct tcctcatttt tgggggtaca cagtgtgcct tgctggcagt gatgtcctat 360 gatcgatacg tggccatctg caaccctttg cattacccta gcattatgac ttggagggtg 420 tgtgttcagc tggctgcggg atcatggacc agcggcattc tggtgtctgt ggtagatacc 480 acttttatac taaggctgcc ttaccgagag agcaatagta ttgctcattt cttttgtgag 540 gcccctgcac tcttgatcct ggcatccaca gacacccaca cttcagagat ggccattttc 600 ctcatgggtg tcataattct cctcatacct gtctccctaa ttctagtatc ctatggccac 660 atcatagtga ctgtggtcag gatgaagtca tctgtgagga ggctcaaggc attctctacc 720 tgtggttccc acctcatggt ggtcatcctc ttttatgggt caggaattgt cacttacatg 780 acaccaaagt cttccaaaga acagaaaaaa cttgtgtctg tgttctatgc aatggtgaca 840 cccatgctca atcccctcat ctatagcttg aggaacaagg atgtgaaggg agctctgagg 900 aaagtggcca caaggaattt cccatgcagg cttgaaatct gccactga 948

<210> 1468 <211> 315 <212> PRT <213> Canis familiaris

<400> 1468 Met 1 Arg Ala Ala Asn Gln Thr Gln Val Thr Glu Phe Leu Leu Leu Gly 5 10 15 Leu Ser Asp Asp Pro His Thr Gln Lys Leu Leu Phe Ile Leu Phe Leu 20 25 30 Gly Val Tyr Leu Val Thr Val Leu Ala Asn Leu Leu Leu Met Arg Leu 35 40 45 Val Gln Ala Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Cys Page 1651

069269_0225_SL.TXT

50 55 60

Asn 65 Leu Ser Leu Ala Asp Leu Cys Phe Ser Thr Asn Ile Val Pro Gln 70 75 80 Ala Leu Val His Leu Leu Ser Arg Lys Lys Ile Ile Ser Phe Thr Arg 85 90 95 Cys Ala Ala Gln Leu Leu Leu Phe Leu Ile Phe Gly Gly Thr Gln Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu His Tyr Pro Ser Ile Met Thr Trp Arg Val Cys Val Gln Leu 130 135 140 Ala Ala Gly Ser Trp Thr Ser Gly Ile Leu Val Ser Val Val Asp Thr 145 150 155 160 Thr Phe Ile Leu Arg Leu Pro Tyr Arg Glu Ser Asn Ser Ile Ala His 165 170 175 Phe Phe Cys Glu Ala Pro Ala Leu Leu Ile Leu Ala Ser Thr Asp Thr 180 185 190 His Thr Ser Glu Met Ala Ile Phe Leu Met Gly Val Ile Ile Leu Leu 195 200 205 Ile Pro Val Ser Leu Ile Leu Val Ser Tyr Gly His Ile Ile Val Thr 210 215 220 Val Val Arg Met Lys Ser Ser Val Arg Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Met Val Val Ile Leu Phe Tyr Gly Ser Gly Ile 245 250 255 Val Thr Tyr Met Thr Pro Lys Ser Ser Lys Glu Gln Lys Lys Leu Val

Page 1652

260

069269_0225_SL.TXT 265 270

Ser Val Phe Tyr Ala Met Val Thr Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Lys Val Ala Thr 290 295 300 Arg Asn Phe Pro Cys Arg Leu Glu Ile Cys His 305 310 315

<210> 1469 <211> 903 <212> DNA <213> Canis familiaris <220>

<221> modified_base <222> (891)..(891) <223> a, c, t, g, unknown or other <400> 1469

atgggagagg aaaaccaaac ctctgtggct gagtttattt tcctgggcct ttcacaggac 60 ttgcagaccc agatcctgct gtttgttctt tttctcctca tttatctttt gactgtgctt 120 gggaacctgc tcatcatcat tctcatcttc atggactctc gacttcacac tcccatgtac 180 ttttttctta gaaacctctc tttcgcagat ctctgtttct ctactagcat cgtccctcag 240 gtgttggtcc atttcctggt aaaaaggaaa acgatttctc ttcttgggtg tatggcacaa 300 atagttgtct tccttctggc tgggtgtaca gagtgtgcac tgctggcagt gatgtcttat 360 gaccggtacg tggctgtctg caagcccctg cactactcta gcatcatgac ccaacaggtg 420 tgtctccagt tggccattgg atcctgggcc agtggagcac tcgtgtctct ggtggatacc 480 acctttactt ttcaactacc ctatcaagga cagaagatta ttaatcacta cttttgtgaa 540 cctcctgccc tcctgaagct ggcttcagca gatacctaca gcacagaaat ggccatcttt 600 gcaatgggcg tggtcatcct cttagctcct gtctgcctga ttctggtctc ctactggaat 660 attatctcca ctgtgatcca gatgcagtct ggggagggga ggctcaaggc tttctctacc 720 tgtggctccc atctcattgt tgttgtcctg ttctatggct caggcatatt cgcctacatg 780

Page 1653

069269_0225_SL.TXT cggccaaact ccaagaccac aaaagagcat gataaaatga tctctgtgtt ctatacagtg gtgactccaa tgttgaaccc cattatttat agcctgagaa ataaggatgt ngctggtgga ttg

840

900

903 <210> 1470 <211> 301 <212> PRT <213> Canis familiaris

<400> 1470 Gln Thr Ser Val Ala Glu Phe Ile Phe Leu Gly Met Gly 1 Glu Glu Asn 5 10 15 Leu Ser Gln Asp Leu Gln Thr Gln Ile Leu Leu Phe Val Leu Phe Leu 20 25 30 Leu Ile Tyr Leu Leu Thr Val Leu Gly Asn Leu Leu Ile Ile Ile Leu 35 40 45 Ile Phe Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln 65 70 75 80 Val Leu Val His Phe Leu Val Lys Arg Lys Thr Ile Ser Leu Leu Gly 85 90 95 Cys Met Ala Gln Ile Val Val Phe Leu Leu Ala Gly Cys Thr Glu Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Ser Ile Met Thr Gln Gln Val Cys Leu Gln Leu 130 135 140 Ala Ile Gly Ser Trp Ala Ser Gly Ala Leu Val Ser Leu Val Asp Thr 145 150 155 160

Page 1654

069269_0225_SL.TXT

Thr Phe Thr Phe Gln 165 Leu Pro Tyr Gln Gly Gln Lys Ile Ile Asn His 170 175 Tyr Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Ala Asp Thr 180 185 190 Tyr Ser Thr Glu Met Ala Ile Phe Ala Met Gly Val Val Ile Leu Leu 195 200 205 Ala Pro Val Cys Leu Ile Leu Val Ser Tyr Trp Asn Ile Ile Ser Thr 210 215 220 Val Ile Gln Met Gln Ser Gly Glu Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Val Leu Phe Tyr Gly Ser Gly Ile 245 250 255 Phe Ala Tyr Met Arg Pro Asn Ser Lys Thr Thr Lys Glu His Asp Lys 260 265 270 Met Ile Ser Val Phe Tyr Thr Val Val Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Ala Gly Gly Leu 290 295 300 <210> 1471 <211> 951 <212> DNA <213> Canis familiaris <400> 1471 atggagtact ggaactccac cttgggcagt ggctttatat tgatggggat tctgaatgac agtgggtctc ctgaactgct ctgtgccaca atcactgtcc tatacatgtt ggctctgacc agcaatggcc tgctgctctt ggtcatcaca gtggattccc ggctccatgt gcccatgtac ttcctgctcg gccagctctc actcatggac ctcctcttca catctgttgt cactcccaag

120

180

240

Page 1655

069269_0225_SL.TXT gccctcgtgg atgtttctgg gacagatatg tgctcactca ttgtatacca atccctcctt gtgacgggag attctgtgta tgctcctccc ctgcccagtt gtcactccag ttgagaaggg atattctgca cattgacgct tggccatatg tggtggccac tgcactaccc tgctgaagtt tgactttcct ctgtgcttca acctgacagt ccctccacaa cactgaaccc tcctgggaaa gagtgaaaac gggtggtgca tcatcctctg ggcctggatc tttctgtaaa ggcctgtgca tttgatgcct catgccctca cgttgtgatg ccccaggcag ccttatctat atatatgttg acgatctcct gaggacttgc aactacatgg ctggcatttc gttcggaaga gatacctccc ctttctgcca aatgagggga tactatggag gacaacatca agcctgagga ccaacacact ttggaggctg tgctggcctt ttttcatgag tgagtgctct tcaggcacct gatatgaact ttgttgcctc agcagaaagc ctgccacatt tctctctttt atcaggaggt gtaccttcta tgcccttcag catggcctat gccaagggtc aggccatacc gctctgtgag cttggtgtat ctatgcacta cctagtcacc catgtatgtc ctctacggtt catgggggcc a

300

360

420

480

540

600

660

720

780

840

900

951 <210> 1472 <211> 316 <212> PRT <213> Canis familiaris <400> 1472

Met Glu Tyr Trp Asn Ser Thr Leu Gly Ser Gly Phe Ile Leu Met Gly 1 5 10 15 Ile Leu Asn Asp Ser Gly Ser Pro Glu Leu Leu Cys Ala Thr Ile Thr 20 25 30 Val Leu Tyr Met Leu Ala Leu Thr Ser Asn Gly Leu Leu Leu Leu Val 35 40 45 Ile Thr Val Asp Ser Arg Leu His Val Pro Met Tyr Phe Leu Leu Gly 50 55 60 Gln Leu Ser Leu Met Asp Leu Leu Phe Thr Ser Val Val Thr Pro Lys 65 70 75 80 Ala Leu Val Asp Ile Leu Gln Ser Glu Asn Thr Ile Ser Phe Gly Gly Page 165 6

069269_0225_SL.TXT

85 90 95

Cys Ala Leu Gln Met Phe Leu Ala Leu Thr Leu Gly Gly Ala Glu Asp 100 105 110 Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Asn Tyr Met Val Phe Met Arg Pro Arg Val Cys Ser Leu Met 130 135 140 Val Ala Thr Ala Trp Ile Leu Ala Phe Leu Ser Ala Leu Gly His Thr 145 150 155 160 Leu Tyr Thr Met His Tyr Pro Phe Cys Lys Val Arg Lys Ile Arg His 165 170 175 Leu Leu Cys Glu Ile Pro Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr 180 185 190 Ser Arg Tyr Glu Leu Leu Val Tyr Val Thr Gly Val Thr Phe Leu Leu 195 200 205 Met Pro Leu Ser Ala Ile Val Ala Ser Tyr Ala Leu Ile Leu Cys Thr 210 215 220 Val Leu His Met Pro Ser Asn Glu Gly Lys Gln Lys Ala Leu Val Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Val Met Tyr Tyr Gly Ala Ala Thr 245 250 255 Phe Met Tyr Val Leu Pro Ser Ser Leu His Asn Pro Arg Gln Asp Asn 260 265 270 Ile Ile Ser Leu Phe Ser Thr Val Val Thr Pro Ala Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Val Met Gly Ala Leu Arg Arg Val

Page 1657

069269_0225_SL.TXT 290 295 300

Leu Gly Lys Tyr Met Leu Pro Thr His Cys Thr Phe 305 310 315

<210> 1473 <211> 951 <212> DNA <213> Canis familiaris <400> 1473

atggagtact ggaactccac cttgggcagt ggctttatat tgatggggat tctgaatgac 60 agtgggtctc ctgaactgct ctgtgccaca atcactgtcc tatacatgtt ggctctgacc 120 agcaatggcc tgctgctctt ggtcatcaca gtggattccc ggctccatgt gcccatgtac 180 ttcctgctcg gccagctctc actcatggac ctcctcttcc catctgtttt cactcccaag 240 accctcatgg attttctgca gagtgaaaac atgatatcct ttggaggctg tgcccttcag 300 atgtttctgg tattgacact gggtggtaca gaggacttgc tgctggcctt catggcctat 360 gacagatatg tagccatatg tcatcctctg aactacatgg ttttcatgag gccaagggtc 420 tgctggctca tggtggccac ggcctggatc ctggcatttc tgagtgctct aggccatacc 480 ttgtatacca tgcactaccc tttctgtaaa gttcggaaga tcaggcacct gctctgtgag 540 atccctcctt tgctgaagtt ggcctgtgca gatacctccc gatatgaact cttggtgtat 600 gtgacgggag tgactttcct tttgatgcct ctttctgcca ttgttgcctc ctatgcacta 660 attctgtgta ctgtgcttca catgccctct aatgaaggga agcagaaagc cctagtcacc 720 tgctcctccc acctgacagt cgttgtgatg tactatggag ctgccacatt catgtatgtc 780 ctgcccagtt ccctccacag ccccaggcag gacaacatca tctctctttt ctacacggtt 840 gtcactccag cactgaaccc ccttatctat agcctgagga atcaggaggt catgggagcc 900 ttgagaaggg tcctgggaaa atatatgttg ccaacacact gtaccttcta a 951

<210> 1474 <211> 316 <212> PRT <213> Canis familiaris <400> 1474

Page 1658

Met 1 Glu Tyr Trp Asn 5 Ser Thr 069269_0225_SL.TXT Leu Gly Ser Gly Phe Ile 10 Leu Met 15 Gly Ile Leu Asn Asp Ser Gly Ser Pro Glu Leu Leu Cys Ala Thr Ile Thr 20 25 30 Val Leu Tyr Met Leu Ala Leu Thr Ser Asn Gly Leu Leu Leu Leu Val 35 40 45 Ile Thr Val Asp Ser Arg Leu His Val Pro Met Tyr Phe Leu Leu Gly 50 55 60 Gln Leu Ser Leu Met Asp Leu Leu Phe Pro Ser Val Phe Thr Pro Lys 65 70 75 80 Thr Leu Met Asp Phe Leu Gln Ser Glu Asn Met Ile Ser Phe Gly Gly 85 90 95 Cys Ala Leu Gln Met Phe Leu Val Leu Thr Leu Gly Gly Thr Glu Asp 100 105 110 Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Asn Tyr Met Val Phe Met Arg Pro Arg Val Cys Trp Leu Met 130 135 140 Val Ala Thr Ala Trp Ile Leu Ala Phe Leu Ser Ala Leu Gly His Thr 145 150 155 160 Leu Tyr Thr Met His Tyr Pro Phe Cys Lys Val Arg Lys Ile Arg His 165 170 175 Leu Leu Cys Glu Ile Pro Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr 180 185 190 Ser Arg Tyr Glu Leu Leu Val Tyr Val Thr Gly Val Thr Phe Leu Leu 195 200 205

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Met Pro Leu Ser Ala Ile Val Ala Ser Tyr Ala Leu Ile Leu Cys Thr 210 215 220 Val Leu His Met Pro Ser Asn Glu Gly Lys Gln Lys Ala Leu Val Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Val Met Tyr Tyr Gly Ala Ala Thr 245 250 255 Phe Met Tyr Val Leu Pro Ser Ser Leu His Ser Pro Arg Gln Asp Asn 260 265 270 Ile Ile Ser Leu Phe Tyr Thr Val Val Thr Pro Ala Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Val Met Gly Ala Leu Arg Arg Val 290 295 300 Leu Gly Lys Tyr Met Leu Pro Thr His Cys Thr Phe 305 310 315

<210> 1475 <211> 951 <212> DNA <213> Canis familiaris <400> 1475 atggagtact ggaactccac cttgggcagt ggctttatat tgatggggat tctgaatgac 60 agtgggtctc ctgaactgct ctgtgccaca atcactgtcc tatacatgtt ggctctgacc 120 agcaatggcc tgctgctctt ggtcatcaca gtggattcct ggctccatgt gcccatgtac 180 ttcctgctcg gccagctctc actcatggac ctcctcttca catctgttgt cactcccaag 240 gccctcgtgg attttctgca gagtgaatac acgatctcct ttggaggctg tgcccttcag 300 atgtttctgg cattggcgct gggtagtgca gaggacttgc tgctggcctt catggcctat 360 gacagatacg tggccatatg tcatcctctg aactacatgg ttttcatgag gccaagggtc 420 tgctggctca tggtggccac ggcctggatc ctggcatttc tgaatgctct aggccatacc 480 ttgtatacca tgcactaccc tttctgtaaa gttcggaaga tcaggcacct gctctgtgag 540

Page 1660

069269_0225_SL.TXT

attcctcctt tgctgaagtt ggcctgtgca gatacctccc gatatgaact cttggtgtat 600 gtgacaggag tgactttcct tttgatgcct ctttctgcca ttgttgcctc ctatgtacta 660 atcctgtgta ctgtgcttca catgccctca aatgagggga agcagaaagc cctagtcacc 720 tgctcctccc atctgacagt ggttgtgatg tactatggag ctgccacgtt catgtatgtc 780 ctgcccagtt ccctccacag ccccaggcag gacaacatca tctctctttt ctacacggtt 840 gtcactccag cactgaaccc ccttatctat agcctgagga atcaggaggt catgggggcc 900 ttgagaaggg tcctgggaaa atatatgttg ccaacacact gtaccttcta a 951

<210> 1476 <211> 316 <212> PRT <213> Canis familiaris <400> 1476

Met Glu Tyr Trp Asn Ser Thr Leu Gly Ser Gly Phe Ile Leu Met Gly 1 5 10 15 Ile Leu Asn Asp Ser Gly Ser Pro Glu Leu Leu Cys Ala Thr Ile Thr 20 25 30 Val Leu Tyr Met Leu Ala Leu Thr Ser Asn Gly Leu Leu Leu Leu Val 35 40 45 Ile Thr Val Asp Ser Trp Leu His Val Pro Met Tyr Phe Leu Leu Gly 50 55 60 Gln Leu Ser Leu Met Asp Leu Leu Phe Thr Ser Val Val Thr Pro Lys 65 70 75 80 Ala Leu Val Asp Phe Leu Gln Ser Glu Tyr Thr Ile Ser Phe Gly Gly 85 90 95 Cys Ala Leu Gln Met Phe Leu Ala Leu Ala Leu Gly Ser Ala Glu Asp 100 105 110 Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125

Page 1661

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Pro Leu 130 Asn Tyr Met Val Phe Met Arg Pro Arg Val Cys Trp Leu Met 135 140 Val Ala Thr Ala Trp Ile Leu Ala Phe Leu Asn Ala Leu Gly His Thr 145 150 155 160 Leu Tyr Thr Met His Tyr Pro Phe Cys Lys Val Arg Lys Ile Arg His 165 170 175 Leu Leu Cys Glu Ile Pro Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr 180 185 190 Ser Arg Tyr Glu Leu Leu Val Tyr Val Thr Gly Val Thr Phe Leu Leu 195 200 205 Met Pro Leu Ser Ala Ile Val Ala Ser Tyr Val Leu Ile Leu Cys Thr 210 215 220 Val Leu His Met Pro Ser Asn Glu Gly Lys Gln Lys Ala Leu Val Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Val Met Tyr Tyr Gly Ala Ala Thr 245 250 255 Phe Met Tyr Val Leu Pro Ser Ser Leu His Ser Pro Arg Gln Asp Asn 260 265 270 Ile Ile Ser Leu Phe Tyr Thr Val Val Thr Pro Ala Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Val Met Gly Ala Leu Arg Arg Val 290 295 300 Leu Gly Lys Tyr Met Leu Pro Thr His Cys Thr Phe

305 310 315 <210> 1477 <211> 933 <212> DNA

Page 1662

069269_0225_SL.TXT <213> Canis familiaris <400> 1477

atggagtact ggaactccac cttgggcagt ggctttatat tgatggggat tctgaatgac 60 agtgggtctc ctgaactgct ctgtgccaca atcactgtcc tatacatgtt ggctctgacc 120 agcaatggcc tgctgctctt ggtcatcaca gtggattccc ggctccatgt gcccatgtac 180 ttcctgctcg gccagctctc actcatggac ctcctcttca catctgttgt cactcccaag 240 gccctcgtgg attttctgca gagtgaatac acgatctcct ttggaggctg tgcccttcag 300 atgtttctgg cattgacgct gggtagtgca gaggacttgc tgctggcctt catggcctat 360 gacagatacg tggccatatg tcatcctctg aactacatgg tcttcatgag gccaagggtc 420 tgctggctca tggtggccac ggcctggatc ctggcatccc taagtgcctt tgtttatacc 480 acatatacca tgcactaccc tttctgtaaa gttcggaaga tcaggcacct gctctgtgag 540 atcccacctt tactgaagtt ggcctgtgca gatacctccc gatatgaact cttggtgtat 600 gtgatgggtg tgaccttcct tatgccccct ctctttacta tcatttcttc atatacacta 660 attctgtgta ctgtgcttca catgccctca aatgaaggga agcagaaagc cctagtcacc 720 tgctcctccc acctgacagt cgttgggatg ttctatggag ctgccacgtt catgtatgtc 780 ctgcccagtt ccctccacaa ccccaggcag gacaacatca tctctctttt ctacacggtt 840 gtcactccag cgttgaaccc ccttatctat agcctgcgaa ataaggaggt catgggagct 900 ttgaagagag tcctggcaaa atacatggcc tga 933

<210> 1478 <211> 310 <212> PRT <213> Canis familiaris

<400> 1478 Ser Thr Leu Gly Ser Gly Phe Ile Leu Met Gly Met 1 Glu Tyr Trp Asn 5 10 15 Ile Leu Asn Asp Ser Gly Ser Pro Glu Leu Leu Cys Ala Thr Ile Thr 20 25 30 Val Leu Tyr Met Leu Ala Leu Thr Ser Asn Gly Leu Leu Leu Leu Val 35 40 45

Page 1663

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Ile Thr 50 Val Asp Ser Arg Leu His 55 Val Pro Met Tyr Phe Leu Leu 60 Gly Gln Leu Ser Leu Met Asp Leu Leu Phe Thr Ser Val Val Thr Pro Lys 65 70 75 80 Ala Leu Val Asp Phe Leu Gln Ser Glu Tyr Thr Ile Ser Phe Gly Gly 85 90 95 Cys Ala Leu Gln Met Phe Leu Ala Leu Thr Leu Gly Ser Ala Glu Asp 100 105 110 Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Asn Tyr Met Val Phe Met Arg Pro Arg Val Cys Trp Leu Met 130 135 140 Val Ala Thr Ala Trp Ile Leu Ala Ser Leu Ser Ala Phe Val Tyr Thr 145 150 155 160 Thr Tyr Thr Met His Tyr Pro Phe Cys Lys Val Arg Lys Ile Arg His 165 170 175 Leu Leu Cys Glu Ile Pro Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr 180 185 190 Ser Arg Tyr Glu Leu Leu Val Tyr Val Met Gly Val Thr Phe Leu Met 195 200 205 Pro Pro Leu Phe Thr Ile Ile Ser Ser Tyr Thr Leu Ile Leu Cys Thr 210 215 220 Val Leu His Met Pro Ser Asn Glu Gly Lys Gln Lys Ala Leu Val Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Gly Met Phe Tyr Gly Ala Ala Thr 245 250 255

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Phe Met Tyr Val Leu Pro Ser Ser Leu His Asn Pro Arg Gln Asp Asn 260 265 270 Ile Ile Ser Leu Phe Tyr Thr Val Val Thr Pro Ala Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Lys Arg Val 290 295 300 Leu Ala Lys Tyr Met Ala

305 310 <210> 1479 <211> 933 <212> DNA <213> Canis familiaris <400> 1479

atgggagaag aaaaccaaac ctatgtgact gaatttgtct tcctgggcct ctcacaggat 60 ccagagacac aagtcctgct ctttttcctt tttcagataa tctacctgct gactgtactg 120 ggaaatctgc ttatcattgt gcttgttcat gtagactcta gacttcacac accaatgtac 180 tttttccttg gaaacttgtc ctttgctgat ctctgttttt ctaccaccac ggtgccccag 240 gtgctggtcc acttcttggt aaagagtaaa accatttctt ttgctggatg ctcaacacag 300 atatttgttt tacttcttgt tgggtgtaca gagtgtgcac tgctggcagt gatgtcctat 360 gaccgatatg tggctgtctg caagcccctg cactactcca ccatcatgac acattggtta 420 tgtgtccagc tggccatagg gtcctgggtt agtggaacat ttgtgtcact ggtggacacc 480 acattcacac tgcgcctgcc ctacagaggg aacaatatca ttaaccattt tttttgtgaa 540 cctcctgccc tcctgaagct ggcttcagca gatacctaca gcacagaaat ggccatcttt 600 gcaatgggtg tggtcatcct cttagctcct gtctgcctga ttctggtctc ctactggaat 660 attatctcca ctgtgattca gatgcagtct ggggagggga gactcaaggc tttctctacc 720 tgtggtaccc atctcattgt tgttgtcctc ttctatgggt cagcaatatt tgcctacatg 780 agaccaaact ccaagataat gaatgaaagg gataaaatga tctctgtgtt ctactcagca 840

Page 1665

900

933

069269_0225_SL.TXT gtgacaccca tgttgaaccc catcatttat agtctgagaa acaaggatgt caaaggtgct ctcaggagag tgactgcaaa attgtctttt tga <210> 1480 <211> 310 <212> PRT <213> Canis familiaris <400> 1480

Met Gly Glu Glu Asn Gln Thr Tyr Val Thr Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Ser Gln Asp Pro Glu Thr Gln Val Leu Leu Phe Phe Leu Phe Gln 20 25 30 Ile Ile Tyr Leu Leu Thr Val Leu Gly Asn Leu Leu Ile Ile Val Leu 35 40 45 Val His Val Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Thr Thr Val Pro Gln 65 70 75 80 Val Leu Val His Phe Leu Val Lys Ser Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Ser Thr Gln Ile Phe Val Leu Leu Leu Val Gly Cys Thr Glu Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Ile Met Thr His Trp Leu Cys Val Gln Leu 130 135 140 Ala Ile Gly Ser Trp Val Ser Gly Thr Phe Val Ser Leu Val Asp Thr 145 150 155 160 Thr Phe Thr Leu Arg Leu Pro Tyr Arg Gly Asn Asn Ile Ile Asn His

Page 1666

165

175

069269_0225_SL.TXT

170

Phe Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Ala 190 Asp Thr 180 185 Tyr Ser Thr Glu Met Ala Ile Phe Ala Met Gly Val Val Ile Leu Leu 195 200 205 Ala Pro Val Cys Leu Ile Leu Val Ser Tyr Trp Asn Ile Ile Ser Thr 210 215 220 Val Ile Gln Met Gln Ser Gly Glu Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Thr His Leu Ile Val Val Val Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Phe Ala Tyr Met Arg Pro Asn Ser Lys Ile Met Asn Glu Arg Asp Lys 260 265 270 Met Ile Ser Val Phe Tyr Ser Ala Val Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Arg Val 290 295 300 Thr Ala Lys Leu Ser Phe

305 310 <210> 1481 <211> 924 <212> DNA <213> Canis familiaris <400> 1481 atgggcacag aaaaccgaac ttatctgact gaatttattt tgctgggcct ttcttcagat 60 tggcagatcc agatcctact gtttgtggtg tttctcatca tctacctact aactctgttt 120 gggaatctta tcatcatagt gctaattcat attgactctc gacttcatac accaatgtac 180 ttcttcctta aaaacctgtc atttactgat ctctgcttct ctacaacgat catcccccag 240

Page 1667

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atgttattcc atttgctggt aataagaaag accatttcct ttgctggatg ttcaattcag 300 atgatttttt tcctagtagc tgggtgtaca gaaagttccc tcctagcagt gatgtcctat 360 gatcgctatg tggctgtctg caagcccctt cactactcca ccctcatgac ccagaaggtg 420 tgtgtacagc tgaccatagg gtcctgggcc actggaatat ttgtgtctct agtagacaca 480 tcatttactt tatgtctctc ataccatggg cagaacataa ttaatcatta tttttgtgaa 540 cctcctgcac tcttgaagtt ggcttcagaa gaaacctaca gagctgagat ggccatcttt 600 gccatgggtg tagtaattct ccttggtcct gtctccctca tccttttctc ctattggaat 660 attatctcta ctgtgattca gatacagtca ggtgagggga ggctcaaggt cttttctacc 720 tgtggttctc atctcatcgt tgttgtcttc ttctatggct caacaatatt tacctacatg 780 cgtccaaatt ccaagaaaat aaatgaaggg gataaggtga tctctgtgtt ctattcagtc 840 ataacatcca tgatgaaccc attcatttat agcctgagaa acaaggatgt gaagaaggca 900 tttaggaaag tatttggaag atag 924 <210> 1482 <211> 307 <212> PRT <213> Canis familiaris <400> 1482 Met Gly Thr Glu Asn Arg Thr Tyr Leu Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Ser Asp Trp Gln Ile Gln Ile Leu Leu Phe Val Val Phe Leu 20 25 30 Ile Ile Tyr Leu Leu Thr Leu Phe Gly Asn Leu Ile Ile Ile Val Leu 35 40 45 Ile His Ile Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Lys 50 55 60 Asn Leu Ser Phe Thr Asp Leu Cys Phe Ser Thr Thr Ile Ile Pro Gln 65 70 75 80

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Met Leu Phe His Leu 85 Leu Val Ile Arg Lys Thr Ile Ser Phe Ala Gly 90 95 Cys Ser Ile Gln Met Ile Phe Phe Leu Val Ala Gly Cys Thr Glu Ser 100 105 110 Ser Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Leu Met Thr Gln Lys Val Cys Val Gln Leu 130 135 140 Thr Ile Gly Ser Trp Ala Thr Gly Ile Phe Val Ser Leu Val Asp Thr 145 150 155 160 Ser Phe Thr Leu Cys Leu Ser Tyr His Gly Gln Asn Ile Ile Asn His 165 170 175 Tyr Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Glu Glu Thr 180 185 190 Tyr Arg Ala Glu Met Ala Ile Phe Ala Met Gly Val Val Ile Leu Leu 195 200 205 Gly Pro Val Ser Leu Ile Leu Phe Ser Tyr Trp Asn Ile Ile Ser Thr 210 215 220 Val Ile Gln Ile Gln Ser Gly Glu Gly Arg Leu Lys Val Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Val Phe Phe Tyr Gly Ser Thr Ile 245 250 255 Phe Thr Tyr Met Arg Pro Asn Ser Lys Lys Ile Asn Glu Gly Asp Lys 260 265 270 Val Ile Ser Val Phe Tyr Ser Val Ile Thr Ser Met Met Asn Pro Phe 275 280 285

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Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Phe Arg Lys Val 290 295 300

Phe Gly Arg 305 <210> 1483 <211> 234 <212> DNA <213> Canis familiaris <400> 1483 atggagctct ggaactccaa tttgggaaat ggcttcatct tggtggggat tctgaatgat 60 aatggagctc ctaaacttct ctatgccaca attgctgtcc tgtacatgtt ggccgtaacc 120 agtagtggcc ttctgctctt ggtcattata atggatgctt ggctctatgt acccatatac 180 ctcctgctca gccagctatc tctcatggac ttaatgtttg catctgttgc atct 234 <210> 1484 <211> 78 <212> PRT <213> Canis familiaris <400> 1484

Met Glu Leu Trp Asn Ser Asn Leu Gly Asn Gly Phe Ile Leu Val Gly 1 5 10 15 Ile Leu Asn Asp Asn Gly Ala Pro Lys Leu Leu Tyr Ala Thr Ile Ala 20 25 30 Val Leu Tyr Met Leu Ala Val Thr Ser Ser Gly Leu Leu Leu Leu Val 35 40 45 Ile Ile Met Asp Ala Trp Leu Tyr Val Pro Ile Tyr Leu Leu Leu Ser 50 55 60 Gln Leu Ser Leu Met Asp Leu Met Phe Ala Ser Val Ala Ser 65 70 75

<210> 1485 <211> 939 <212> DNA

Page 1670

069269_0225_SL.TXT <213> Canis familiaris <400> 1485 atggagactg aaaaccatac aatggtgaca gagttcatta ttttggggtt aacagaggat 60 cctacacttt gtaccatctt ctttgtggtt tttctaggaa tctatgtcgc taccctactg 120 ggcaatgtca gcataatcat gctgatccac agaagtcctc agcttcacac cccaatgtat 180 cttttcctca gccatttagc ctttgtggat atcgggtatt ccacgtcagt cacacccatt 240 atgattgtgg gtttcttaag agagagaact actatccctg ttgctggctg catagctcag 300 cttggctctg atgttatctt tggaacagct gagtgcttcc tgctggccgc catggcctat 360 gatcgctatg tggccatctg ctctccactt ctctactcta cacacatgtc ttccagagtc 420 tgcatcatcc tcttggctgc ttcctatctg gggggatgtg tgaatgcttc atcatttact 480 ggctgtctac tgagcttgac tttctgtgga ccaaataaaa tcaatcattt cttttgtgac 540 ttcccaccac tagtaaagct ttcttgtacc catatttatg ttgctgaaac atcacctgct 600 atcctagccg ggtccatcat tgtaatcaca ctgtttatca tagctatttc atatctatac 660 atcctgcatt cagtcctaaa tatgcgctcc cctgaaggaa gacacaaggc cttctccact 720 tgtacttctc acctcagtgc agtcactttg ttttatggga cagtcacatt tgtttatgtc 780 atacccaagt cagattactc gtctgatcat attaaagtgg tgtctgtgtt ctacacagtg 840 gtgatcccca tgttgaaccc cttgatctat agtctgagaa acaaagaggt taaagaggcc 900 acgagaaaat tgatggctag aagacattgg ttattttga 939 <210> 1486 <211> 312 <212> PRT <213> Canis familiaris

<400> 1486 His Thr Met Val Thr Glu Phe Ile Ile Leu Gly Met 1 Glu Thr Glu Asn 5 10 15 Leu Thr Glu Asp Pro Thr Leu Cys Thr Ile Phe Phe Val Val Phe Leu 20 25 30 Gly Ile Tyr Val Ala Thr Leu Leu Gly Asn Val Ser Ile Ile Met Leu 35 40 45

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Ile His 50 Arg Ser Pro Gln Leu His 55 Thr Pro Met Tyr Leu Phe Leu 60 Ser His Leu Ala Phe Val Asp Ile Gly Tyr Ser Thr Ser Val Thr Pro Ile 65 70 75 80 Met Ile Val Gly Phe Leu Arg Glu Arg Thr Thr Ile Pro Val Ala Gly 85 90 95 Cys Ile Ala Gln Leu Gly Ser Asp Val Ile Phe Gly Thr Ala Glu Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr Ser Thr His Met Ser Ser Arg Val Cys Ile Ile Leu 130 135 140 Leu Ala Ala Ser Tyr Leu Gly Gly Cys Val Asn Ala Ser Ser Phe Thr 145 150 155 160 Gly Cys Leu Leu Ser Leu Thr Phe Cys Gly Pro Asn Lys Ile Asn His 165 170 175 Phe Phe Cys Asp Phe Pro Pro Leu Val Lys Leu Ser Cys Thr His Ile 180 185 190 Tyr Val Ala Glu Thr Ser Pro Ala Ile Leu Ala Gly Ser Ile Ile Val 195 200 205 Ile Thr Leu Phe Ile Ile Ala Ile Ser Tyr Leu Tyr Ile Leu His Ser 210 215 220 Val Leu Asn Met Arg Ser Pro Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Thr Ser His Leu Ser Ala Val Thr Leu Phe Tyr Gly Thr Val Thr 245 250 255

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Phe Val Tyr Val Ile Pro Lys Ser Asp Tyr Ser Ser Asp His Ile Lys 260 265 270 Val Val Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Thr Arg Lys Leu 290 295 300 Met Ala Arg Arg His Trp Leu Phe

305 310 <210> 1487 <211> 939 <212> DNA <213> Canis familiaris <400> 1487

atggagaatg aaaatcatac aacagtgaca gagttcatta ttctgggatt aacagataat 60 cccacactat gtgccatctt ctttgtgatt ttcctgggag tttatataat taccatagtg 120 ggaaatatca gtataatcat cctaatccga agcagcccac agcttcacac cccgatgtac 180 ctttttctca gccatttggc ctttgtagac attgggtatt ccacctcagt gactccgatc 240 atgctaatga gtttcttaag agagaaaacg actatccctg tcactggctg tatagcccag 300 cttggctctg atgtcacttt tgggactaca gagtgcttcc tgctggccac catggcctat 360 gatcgctatg tggccatctg ctctcccttg ctctactcca cccagatgtc cccagtggtc 420 tgcttcctcc tattgggggc ttcctacctg ggtggatgca tgaacgcttc atcatttact 480 ggctgtttga tgaatctaac cttctgtgga ccaaacaaaa tcaaccattt cttctgtgac 540 ctctttccac tcttgaagct ttcttgtggc catgtttata ttgccgaaat atcgcccgcc 600 atctcttccg catccgtcct cataagcaca ctgtttacca taattgtgtc ctatacctac 660 attctccact caatcctgaa tatgcgctct actgagggga gaaagaaggc cttctcaacc 720 tgcacctccc acctcaccgc agtcactttg ttttatggga cagttttgtt cgtttatgtg 780 atgcccaagt caacttattc agctgatcag gtcaaagtgg catctgtgat ctatacagtg 840

Page 1673

900

939

069269_0225_SL.TXT gtagtcccca tgttgaaccc cctcatctat agcctgagaa acaaggaggt aaaaggagcc atgcgaaaac taatggctaa aatgcattgg ttctcctga <210> 1488 <211> 312 <212> PRT <213> Canis familiaris <400> 1488

Met Glu Asn Glu Asn His Thr Thr Val Thr Glu Phe Ile Ile Leu Gly 1 5 10 15 Leu Thr Asp Asn Pro Thr Leu Cys Ala Ile Phe Phe Val Ile Phe Leu 20 25 30 Gly Val Tyr Ile Ile Thr Ile Val Gly Asn Ile Ser Ile Ile Ile Leu 35 40 45 Ile Arg Ser Ser Pro Gln Leu His Thr Pro Met Tyr Leu Phe Leu Ser 50 55 60 His Leu Ala Phe Val Asp Ile Gly Tyr Ser Thr Ser Val Thr Pro Ile 65 70 75 80 Met Leu Met Ser Phe Leu Arg Glu Lys Thr Thr Ile Pro Val Thr Gly 85 90 95 Cys Ile Ala Gln Leu Gly Ser Asp Val Thr Phe Gly Thr Thr Glu Cys 100 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr Ser Thr Gln Met Ser Pro Val Val Cys Phe Leu Leu 130 135 140 Leu Gly Ala Ser Tyr Leu Gly Gly Cys Met Asn Ala Ser Ser Phe Thr 145 150 155 160 Gly Cys Leu Met Asn Leu Thr Phe Cys Gly Pro Asn Lys Ile Asn His

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165 170 175

Phe Phe Cys Asp Leu Phe Pro Leu Leu Lys Leu Ser Cys Gly 190 His Val 180 185 Tyr Ile Ala Glu Ile Ser Pro Ala Ile Ser Ser Ala Ser Val Leu Ile 195 200 205 Ser Thr Leu Phe Thr Ile Ile Val Ser Tyr Thr Tyr Ile Leu His Ser 210 215 220 Ile Leu Asn Met Arg Ser Thr Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Thr Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Thr Val Leu 245 250 255 Phe Val Tyr Val Met Pro Lys Ser Thr Tyr Ser Ala Asp Gln Val Lys 260 265 270 Val Ala Ser Val Ile Tyr Thr Val Val Val Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Met Arg Lys Leu 290 295 300 Met Ala Lys Met His Trp Phe Ser

305 310 <210> 1489 <211> 969 <212> DNA <213> Canis familiaris <400> 1489 atgatgggca atcataccac agtgagcaca ttccttctgt gggggttttc tagtttccca gacttgcaga ctctcctctt tgtgatgatt ttcttctccc atgtgaccat cctagccgca aatgtgtccg taatggtggc catcaggctc agtcacaacc ttcacacccc tatgtacttt ttcctctgcg gcctgtcctt ttcagaaacg tgtaccacga tggcaatcat accccgcatg

120

180

240

Page 1675

069269_0225_SL.TXT ttagtggact tgctagcaga tttttcttct ttggcttggg cgttatattg ccattcacaa tttcagctcc tcatggcctc attgtattca acttgtcttt tcacctgtgg tctgccttgc ttcactgcct ttgtgttggt gcatccactg ttgcgaagat tcctcccacc tcactgtggt cccaaggaca gggacttgtt acccctctgc ttaacccgat aggaaggttc taggcaagac gacagttaa <210> 1490 <211> 322 <212> PRT <213> Canis familiaris ctgcaagacc atttctcttc agccaataac tgcttcatca cccgctgcac taccccatct ttggatggct gggttcctgg ctgtgactcc aacatcatcc ctgtgattac accttttttc gggcagcttt gtctttatta gccctctgcc aaggggaggt gtgcatacac tatggatttg ccgtgaggac atgttgatgg tgtttatagt ctcagaaaca agataggttc atccctcaga ctgagtgtgc cacacagatg tggctgccat gtcctatgac tgatgaccca taagatctgc tttctctgtg catcgtcatc agcacttctt ctgtgatatc aaaaaatggt tctttttgca tgatgtccta tgtcttcatt ataaggcctt ttccacttgc ctggctttgt ctacttgagg ctgtcacata tacggtgctg aagaaatgca gactgcccta tggtgaataa acgaacaccg

300

360

420

480

540

600

660

720

780

840

900

960

969

<400> 1490 Met Met Gly Asn His Thr 1 5 Ser Ser Phe Pro 20 Asp Leu Ser His Val Thr 35 Ile Leu Arg Leu Ser His 50 Asn Leu Leu Ser Phe Ser 65 Glu Thr 70

Thr Val Ser Thr 10 Phe Gln Thr Leu 25 Leu Phe Ala Ala 40 Asn Val Ser His 55 Thr Pro Met Tyr Cys Thr Thr Met Ala 75

Leu Leu Trp Gly 15 Phe Val Met Ile 30 Phe Phe Val Met 45 Val Ala Ile Phe 60 Phe Leu Cys Gly Ile Ile Pro Arg Met 80

Page 1676

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Leu Val Asp Leu Leu Ala Asp Cys 85 Lys Thr Ile Ser Leu Pro Glu Cys 90 95 Ala Thr Gln Met Phe Phe Phe Phe Gly Leu Gly Ala Asn Asn Cys Phe 100 105 110 Ile Met Ala Ala Met Ser Tyr Asp Arg Tyr Ile Ala Ile His Asn Pro 115 120 125 Leu His Tyr Pro Ile Leu Met Thr His Lys Ile Cys Phe Gln Leu Leu 130 135 140 Met Ala Ser Trp Met Ala Gly Phe Leu Val Ser Leu Cys Ile Val Ile 145 150 155 160 Ile Val Phe Asn Leu Ser Phe Cys Asp Ser Asn Ile Ile Gln His Phe 165 170 175 Phe Cys Asp Ile Ser Pro Val Val Cys Leu Ala Cys Asp Tyr Thr Phe 180 185 190 Phe Gln Lys Met Val Leu Phe Ala Phe Thr Ala Phe Val Leu Val Gly 195 200 205 Ser Phe Val Phe Ile Met Met Ser Tyr Val Phe Ile Ala Ser Thr Val 210 215 220 Ala Lys Met Pro Ser Ala Lys Gly Arg Tyr Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Thr Val Val Cys Ile His Tyr Gly Phe Ala Gly Phe 245 250 255 Val Tyr Leu Arg Pro Lys Asp Arg Asp Leu Phe Arg Glu Asp Met Leu 260 265 270 Met Ala Val Thr Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Ile Val 275 280 285

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Tyr Ser Leu Arg Asn Lys Glu Met Gln Thr Ala Leu Arg Lys Val Leu 290 295 300 Gly Lys Thr Asp Arg Phe Ile Pro Gln Met Val Asn Lys Arg Thr Pro 305 310 315 320 Asp Ser

<210> 1491 <211> 966 <212> DNA <213> Canis familiaris <400> 1491

atgggcaatc ataccacagt gagcacattc cttctgtggg ggttttccag tttcccagac 60 ttgcagactc tcctctttgt gatgattttc ttctcccatg tgaccatcct agccgcaaat 120 gtgtccgtaa tggtggccat caggctcagt cacaaccttc acacccctat gtactttttc 180 ctctgcggcc tgtccttttc agaaacgtgt accacgatgg caatcatacc ccgcatgtta 240 gtggacttgc tagcagactg caagaccatt tctcttcctg agtgtgccac acagatgttt 300 ttcttctttg gcttagcagc caataattgc ttcatcatgg ctgccatgtc ctatgaccgt 360 tatattgcca ttcacaaccc gctgcactac cccatcttga tgacccataa gatctgcttt 420 cagctcctca tggcctcttg gatggctggg ttcctggttt ctctgtgcat cgtcatcatt 480 gtattcaact tgtctttctg tgactccaac atcatccagc acttcttctg tgatatctca 540 cctgtggtct gccttgcctg tgattacacc tcccatcaag aaatggctat ttttgtgctc 600 tctgcctttg tgttggtggg cagctttgtc ttcattatga tgtcctatgt cttcattgtg 660 tccaccgttg tgaagatgcc ctctgccaag gggaggtata aggccttttc cacttgctcc 720 tcccacctca ctgtggtgtg catacactat ggatttgctg gctttgtcta cttgaggccc 780 aaggacaggg actcgttccg tgaggacatg ctgatggctg tcacatatac ggtgctgacc 840 cctctgctta acccgattgt ttatagtctc agaaacaaag aaatgcagac tgccctaagg 900 aaggtgctag gcaggacaga taggttcatc cctcagatgg tgaataaacg aacaccgcac 960

Page 1678

069269_0225_SL.TXT agttaa

966 <210> 1492 <211> 321 <212> PRT <213> Canis familiaris

<400> 1492 Met 1 Gly Asn His Thr 5 Thr Val Ser Thr Phe 10 Leu Leu Trp Gly Phe 15 Ser Ser Phe Pro Asp Leu Gln Thr Leu Leu Phe Val Met Ile Phe Phe Ser 20 25 30 His Val Thr Ile Leu Ala Ala Asn Val Ser Val Met Val Ala Ile Arg 35 40 45 Leu Ser His Asn Leu His Thr Pro Met Tyr Phe Phe Leu Cys Gly Leu 50 55 60 Ser Phe Ser Glu Thr Cys Thr Thr Met Ala Ile Ile Pro Arg Met Leu 65 70 75 80 Val Asp Leu Leu Ala Asp Cys Lys Thr Ile Ser Leu Pro Glu Cys Ala 85 90 95 Thr Gln Met Phe Phe Phe Phe Gly Leu Ala Ala Asn Asn Cys Phe Ile 100 105 110 Met Ala Ala Met Ser Tyr Asp Arg Tyr Ile Ala Ile His Asn Pro Leu 115 120 125 His Tyr Pro Ile Leu Met Thr His Lys Ile Cys Phe Gln Leu Leu Met 130 135 140 Ala Ser Trp Met Ala Gly Phe Leu Val Ser Leu Cys Ile Val Ile Ile 145 150 155 160 Val Phe Asn Leu Ser Phe Cys Asp Ser Asn Ile Ile Gln His Phe Phe 165 170 175

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Cys Asp Ile Ser Pro Val Val Cys Leu Ala Cys Asp Tyr Thr Ser His 180 185 190 Gln Glu Met Ala Ile Phe Val Leu Ser Ala Phe Val Leu Val Gly Ser 195 200 205 Phe Val Phe Ile Met Met Ser Tyr Val Phe Ile Val Ser Thr Val Val 210 215 220 Lys Met Pro Ser Ala Lys Gly Arg Tyr Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Leu Thr Val Val Cys Ile His Tyr Gly Phe Ala Gly Phe Val 245 250 255 Tyr Leu Arg Pro Lys Asp Arg Asp Ser Phe Arg Glu Asp Met Leu Met 260 265 270 Ala Val Thr Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Ile Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Met Gln Thr Ala Leu Arg Lys Val Leu Gly 290 295 300 Arg Thr Asp Arg Phe Ile Pro Gln Met Val Asn Lys Arg Thr Pro His 305 310 315 320

Ser <210> 1493 <211> 945 <212> DNA <213> Canis familiaris <400> 1493 atggattccc tggtggatgg gaaccacact gcagtgacag ggttcatttt attgggccta actgaggacc ctgtccttcg agtcatcctc ttcatgacca tcctctgcat ctacctggtg accgtatctg gcaaccttag cacgatcatt ctgatcaggt tctcctctca gctccaccac

120

180

Page 1680

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cccatgtatt tttttctgag ccacttggcc ttggctgacc taggctattc ctcttctgtc 240 acacccaaca tgcttataaa cttcctggtg gagagaaata tgatctccta tcttggatgt 300 gctatccagc tgggttcagt tgttttcttt gggtcaagtg agtgcttcct tctggctgca 360 atggcatatg atcgcttcat ggccatctgc aacccactgc tttattcaac caaaatgtgc 420 acacaggttt atgttcgcct actcacagtg acttacctag gtggttttct caatgcttgc 480 tctttcacta tttccttctc ttttttactt ttctgtggac caaatcaagt caatcatttt 540 ttctgtgatt ttgctccttt agttaaactc tcctgctctg atagtagaat ccctgcggtt 600 gtcccctcat ttacagctgg ctccatcatt gtggtcacga tgtgtgtcat agtcatctcc 660 tatatctgta tcctcatcac catcctgaag atgagctcca ctgagggacg ccacaaggcc 720 ttctccacct gcacatccca cctcacagtg gtgactctgt tctttgggac cattacattc 780 atttatgtga tgcccaagtc ctgctactcg actgaccaga acaaggtggt gtctttgttc 840 tacatggtgg tggtccccat gttgaacccc ctcatctata gcctcaggaa caatgagatg 900 aagggggctc tgaagagaga gcttggcaga aaaatatttc cttag 945

<210> 1494 <211> 314 <212> PRT <213> Canis familiaris

<400> 1494 Met Asp Ser Leu 1 Val 5 Asp Gly Asn His Thr Ala Val Thr Gly Phe Ile 10 15 Leu Leu Gly Leu Thr Glu Asp Pro Val Leu Arg Val Ile Leu Phe Met 20 25 30 Thr Ile Leu Cys Ile Tyr Leu Val Thr Val Ser Gly Asn Leu Ser Thr 35 40 45 Ile Ile Leu Ile Arg Phe Ser Ser Gln Leu His His Pro Met Tyr Phe 50 55 60 Phe Leu Ser His Leu Ala Leu Ala Asp Leu Gly Tyr Ser Ser Ser Val 65 70 75 80

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Thr Pro Asn Met Leu 85 Ile Asn Phe Leu Val Glu Arg Asn Met Ile Ser 90 95 Tyr Leu Gly Cys Ala Ile Gln Leu Gly Ser Val Val Phe Phe Gly Ser 100 105 110 Ser Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Met Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Ser Thr Lys Met Cys Thr Gln Val Tyr 130 135 140 Val Arg Leu Leu Thr Val Thr Tyr Leu Gly Gly Phe Leu Asn Ala Cys 145 150 155 160 Ser Phe Thr Ile Ser Phe Ser Phe Leu Leu Phe Cys Gly Pro Asn Gln 165 170 175 Val Asn His Phe Phe Cys Asp Phe Ala Pro Leu Val Lys Leu Ser Cys 180 185 190 Ser Asp Ser Arg Ile Pro Ala Val Val Pro Ser Phe Thr Ala Gly Ser 195 200 205 Ile Ile Val Val Thr Met Cys Val Ile Val Ile Ser Tyr Ile Cys Ile 210 215 220 Leu Ile Thr Ile Leu Lys Met Ser Ser Thr Glu Gly Arg His Lys Ala 225 230 235 240 Phe Ser Thr Cys Thr Ser His Leu Thr Val Val Thr Leu Phe Phe Gly 245 250 255 Thr Ile Thr Phe Ile Tyr Val Met Pro Lys Ser Cys Tyr Ser Thr Asp 260 265 270 Gln Asn Lys Val Val Ser Leu Phe Tyr Met Val Val Val Pro Met Leu 275 280 285

Page 1682

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Asn Pro Leu Ile Tyr Ser Leu Arg Asn Asn Glu Met Lys Gly Ala Leu 290 295 300

Lys Arg Glu Leu Gly Arg Lys Ile Phe Pro

305 310 <210> 1495 <211> 951 <212> DNA <213> Canis familiaris <400> 1495

atgagagaga acaaaatggc aagaggcaac cgtaccacag tgacagaatt tgtccttatg 60 ggattcacag accgcccaga gctccagctt cccctctttg tggtgttcct ggcaatgtat 120 ctcatcacct tggtggggaa cctgggcatg attcttctca tcaaggtgga ttggaggctc 180 cataccccca tgtactattt cctcagccac ctggcattca tcgatatctg ttactcatct 240 accattgggc ccaagatgct acaaaactta ttggtgaaga aaaaaaccat ctccttctca 300 ggctgctttg cccagctgta cttctccagt gctttggcca ctactgaatg cttcctcttg 360 gccacaatgg cctatgaccg ctacatggct atctgcaacc cgctgattta cacagccatt 420 atgactcagc gggtctgcaa ggagttggtg gtaggggtct acacctacgg cttcttaaac 480 tctgtaatac aaacagttct gacattccag ttgtctttct gcgactccaa catcatccac 540 cacttctact gtgctgaccc tcctctcctt gccctctcct gctctgacac cggcaacaaa 600 gaaaagcagc tcttgatctt ctctgcagtg aatctcactg gatccctcct gactgtcctc 660 atctcctaca tttgcatcct ctttgccatt ataaaaatcc agtcttccga aggcaaatgt 720 aaagcctttt ccacctgtgc ctctcacctc actgtggtca tcatcttcta tggaacgttg 780 tttttcatgt atctacagca acctaaagca ggggattcgt ggaagtacaa caaagtggtc 840 tctgtgtttt atagtcttgt aattcccctg ctcaaccccc tgatctatac cctgaggaac 900 acagaagtaa aggacaccct gaaaaagatg ctacacggca gagggccata g 951

<210> 1496 <211> 316 <212> PRT

Page 1683

069269_0225_SL.TXT <213> Canis familiaris <400> 1496

Met Arg Glu Asn Lys Met Ala Arg Gly Asn Arg Thr Thr Val Thr Glu 1 5 10 15 Phe Val Leu Met Gly Phe Thr Asp Arg Pro Glu Leu Gln Leu Pro Leu 20 25 30 Phe Val Val Phe Leu Ala Met Tyr Leu Ile Thr Leu Val Gly Asn Leu 35 40 45 Gly Met Ile Leu Leu Ile Lys Val Asp Trp Arg Leu His Thr Pro Met 50 55 60 Tyr Tyr Phe Leu Ser His Leu Ala Phe Ile Asp Ile Cys Tyr Ser Ser 65 70 75 80 Thr Ile Gly Pro Lys Met Leu Gln Asn Leu Leu Val Lys Lys Lys Thr 85 90 95 Ile Ser Phe Ser Gly Cys Phe Ala Gln Leu Tyr Phe Ser Ser Ala Leu 100 105 110 Ala Thr Thr Glu Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr 115 120 125 Met Ala Ile Cys Asn Pro Leu Ile Tyr Thr Ala Ile Met Thr Gln Arg 130 135 140 Val Cys Lys Glu Leu Val Val Gly Val Tyr Thr Tyr Gly Phe Leu Asn 145 150 155 160 Ser Val Ile Gln Thr Val Leu Thr Phe Gln Leu Ser Phe Cys Asp Ser 165 170 175 Asn Ile Ile His His Phe Tyr Cys Ala Asp Pro Pro Leu Leu Ala Leu 180 185 190 Ser Cys Ser Asp Thr Gly Asn Lys Glu Lys Gln Leu Leu Ile Phe Ser

Page 1684

195 069269_0225_SL.TXT 200 205 Ala Val Asn Leu Thr Gly Ser Leu Leu Thr Val Leu Ile Ser Tyr Ile 210 215 220 Cys Ile Leu Phe Ala Ile Ile Lys Ile Gln Ser Ser Glu Gly Lys Cys 225 230 235 240 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Ile Phe 245 250 255 Tyr Gly Thr Leu Phe Phe Met Tyr Leu Gln Gln Pro Lys Ala Gly Asp 260 265 270 Ser Trp Lys Tyr Asn Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile 275 280 285 Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Thr Glu Val Lys 290 295 300 Asp Thr Leu Lys Lys Met Leu His Gly Arg Gly Pro 305 310 315

<210> 1497 <211> 945 <212> DNA <213> Canis familiaris <400> 1497

atgaaaaggc aaaatcaaag ctctgtggtt gaattcatcc tcttgggctt ttccaacttt 60 cctgaactcc aagagcagct ctttggggtt ttcctggctg tttacctggt gactctgatg 120 ggaaatgcca tcattatagt catcatcacc ttggaacaga cgctccacgt gcccatgtat 180 ctgttcctcc agaacctgtc tgtggtggac atgagtttca gcgcagtcat tatgcctgaa 240 atgctggtgg tcctcaccag ggagaaaacg tccatttcat ttgtgagcta ttttgcacag 300 atgtatttca tccttttctt tggtggcact gaatgttttc tcctgggggc gatggcttat 360 gaccgatttg ctgcaatctg tcaccctctg agctacccaa tgataatgaa caaaagggtt 420 ttcatgaaat tacttataac atcatgggcc ttaggcttca tgttaggtac tgtgcaaaca 480

Page 1685

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tcatgggttt ccagttttcc cttttgtggc cccaatgaaa tcaatcatat ctcttgtgaa 540 accccagcag tgctagaact tgcatgtgca gacacgtttc tgtttgaaat ctatgcattc 600 actggcacca ttttgattat catggttcct ttcgtgttga tactcttgtc atacatttgg 660 attctctttg ccatcctgag gatgccatca gctactggga ggcaaaaggc cttttccact 720 tgtgcctccc atctcacgtc tgtgaccctc ttctatggca cagccagtat gacttattta 780 caacccaaat ctggctactc ccctgaaacc aagaagctga tgtcattgtc ttactcactt 840 cttacacctc tgctgaatcc actgatctat agcttcagaa atagtgagat gaaaagagct 900 ttgatgaaac tatggcgaag aagagtggat ttacacacat tctga 945

<210> 1498 <211> 314 <212> PRT <213> Canis familiaris <400> 1498

Met Lys Arg Gln Asn Gln Ser Ser Val Val Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asn Phe Pro Glu Leu Gln Glu Gln Leu Phe Gly Val Phe Leu 20 25 30 Ala Val Tyr Leu Val Thr Leu Met Gly Asn Ala Ile Ile Ile Val Ile 35 40 45 Ile Thr Leu Glu Gln Thr Leu His Val Pro Met Tyr Leu Phe Leu Gln 50 55 60 Asn Leu Ser Val Val Asp Met Ser Phe Ser Ala Val Ile Met Pro Glu 65 70 75 80 Met Leu Val Val Leu Thr Arg Glu Lys Thr Ser Ile Ser Phe Val Ser 85 90 95 Tyr Phe Ala Gln Met Tyr Phe Ile Leu Phe Phe Gly Gly Thr Glu Cys 100 105 110

Page 1686

Phe Leu Leu 115 Gly Ala Met Ala 069269_0225_SL.TXT Tyr Asp Arg Phe Ala Ala 120 125 Ile Cys His Pro Leu Ser Tyr Pro Met Ile Met Asn Lys Arg Val Phe Met Lys Leu 130 135 140 Leu Ile Thr Ser Trp Ala Leu Gly Phe Met Leu Gly Thr Val Gln Thr 145 150 155 160 Ser Trp Val Ser Ser Phe Pro Phe Cys Gly Pro Asn Glu Ile Asn His 165 170 175 Ile Ser Cys Glu Thr Pro Ala Val Leu Glu Leu Ala Cys Ala Asp Thr 180 185 190 Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Ile Leu Ile Ile Met 195 200 205 Val Pro Phe Val Leu Ile Leu Leu Ser Tyr Ile Trp Ile Leu Phe Ala 210 215 220 Ile Leu Arg Met Pro Ser Ala Thr Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Ser 245 250 255 Met Thr Tyr Leu Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys 260 265 270 Leu Met Ser Leu Ser Tyr Ser Leu Leu Thr Pro Leu Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Phe Arg Asn Ser Glu Met Lys Arg Ala Leu Met Lys Leu 290 295 300 Trp Arg Arg Arg Val Asp Leu His Thr Phe

305 310

Page 1687

069269_0225_SL.TXT <210> 1499 <211> 945 <212> DNA <213> Canis familiaris <400> 1499

atgaaaaggc aaaatcaaag ctctgtggtt gaattcatcc tcttgggctt ttccaacttt 60 cctgaactcc aagagcagct ctttggggtt ttcctggctg tttacctggt gactctgatg 120 ggaaatgcca tcattatagt catcatcacc ttggaacaga ccctccacgt gcccatgtat 180 ctgttcctcc agaacctgtc tgtggtggac gtgagtttca gcgcagtcat tatgcctgaa 240 atgctggtgg tcctcaccag ggagaaaacg tccatttcat ttatgagctg ttttgcacag 300 atgtatttca tccttttctt tggtggcact gaatgttttc tcctggggac gatggcttat 360 gaccgatttg ctgcaatctg tcaccctctg agctacccaa tgattatgaa caaaagagtt 420 ttcatgaaat tagtaatgtt ctcatgggtc tcagggatca tggtggctac tgtgcagacc 480 acatgggttt tcagttttcc tttttgtggc cccaatgtaa tcaatcatct cttttgtgag 540 actcccccag tgctagaact tgcatgtgca gacacgtttc tgtttgaaat ctatgcattc 600 actggcacca ttttgattgt catggttcct ttcgtgttga tactcttgtc atacattcgg 660 attctctttg ccatcctgag gatgccatca gccacgggga ggcaaaaggc cttttccact 720 tgtgcctccc atctcacttc tgtgaccctc ttctatggca cagccagtat gacttattta 780 caacccaaat ctggctactc ccctgaaacc aagaagctga tgtcattgtc ttactcactt 840 cttacacctc tgctgaatcc actgatctac agcttcagaa atagtgagat gaaaagagct 900 ttgatgaaac tatggcgaag aagagtggat atacatgcat tctga 945

<210> 1500 <211> 314 <212> PRT <213> Canis familiaris <400> 1500

Met Lys Arg Gln Asn Gln Ser Ser Val Val Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asn Phe Pro Glu Leu Gln Glu Gln Leu Phe Gly Val Phe Leu

20 25 30

Page 1688

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Ala Val Tyr 35 Leu Val Thr Leu Met Gly Asn Ala Ile Ile Ile Val Ile 40 45 Ile Thr Leu Glu Gln Thr Leu His Val Pro Met Tyr Leu Phe Leu Gln 50 55 60 Asn Leu Ser Val Val Asp Val Ser Phe Ser Ala Val Ile Met Pro Glu 65 70 75 80 Met Leu Val Val Leu Thr Arg Glu Lys Thr Ser Ile Ser Phe Met Ser 85 90 95 Cys Phe Ala Gln Met Tyr Phe Ile Leu Phe Phe Gly Gly Thr Glu Cys 100 105 110 Phe Leu Leu Gly Thr Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His 115 120 125 Pro Leu Ser Tyr Pro Met Ile Met Asn Lys Arg Val Phe Met Lys Leu 130 135 140 Val Met Phe Ser Trp Val Ser Gly Ile Met Val Ala Thr Val Gln Thr 145 150 155 160 Thr Trp Val Phe Ser Phe Pro Phe Cys Gly Pro Asn Val Ile Asn His 165 170 175 Leu Phe Cys Glu Thr Pro Pro Val Leu Glu Leu Ala Cys Ala Asp Thr 180 185 190 Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Ile Leu Ile Val Met 195 200 205 Val Pro Phe Val Leu Ile Leu Leu Ser Tyr Ile Arg Ile Leu Phe Ala 210 215 220 Ile Leu Arg Met Pro Ser Ala Thr Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240

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Cys Ala Ser His Leu 245 Thr Met Thr Tyr Leu 260 Gln Pro Leu Met Ser 275 Leu Ser Tyr Ile Tyr 290 Ser Phe Arg Asn Trp 305 Arg Arg Arg Val Asp 310

Ser Val Thr Leu 250 Phe Lys Ser Gly 265 Tyr Ser Ser Leu 280 Leu Thr Pro Ser 295 Glu Met Lys Arg Ile His Ala Phe

Tyr Gly Thr Ala 255 Ser Pro Glu Thr 270 Lys Lys Leu Leu 285 Asn Pro Leu Ala Leu Met Lys Leu

300 <210> 1501 <211> 945 <212> DNA <213> Canis familiaris <400> 1501 atgaaaaggc aaaatcaaag cctgaactcc aagagcagct ggaaatgcca tcattatagt ctgttcctcc agaacctgtc atgctggtgg tcctcaccag atgtatttca tccttttctt gaccgatttg ttgcaatctg ttcatgaaat tagtaatgtt acatgggttt tcagttttcc actcccccag tgctagaact actggtacca ttttgattgt attctctttg ccatcctgag tgtgcctccc atctcacgtc ctctgtggtt gaattcatcc ccttggggtt ttcctggctg catcatcgcc ttggaacaga tgtggtggac atgagtttca ggagaaaacg tccatttcat tggtggcact gaatgttttc tcaccctctg agctacccaa ctcatgggtc tcagggatca tttttgtggt cccaacgaaa tgcatgtgca gacacgtttc catggttcct tttgtgttga gatgccatca gccactggga tgtgaccctc ttctatggca

Page 1690 tcttgggctt ttctaacttt tttacctggt gactctgatg ccctccacgt gcccatgtat gcgcagtcat tatgcctgaa ttgtgagctg ttttgcacag tcctggggac gatggcttat tgattatgaa caaaagggtt tggtggctac tgtgcagacc tcaatcatct cttctgtgag tgtttgaaat ctatgcattc tactcctgtc ttatattcgg ggcaaaaggc cttttccact cagccagtat gacttattta

120

180

240

300

360

420

480

540

600

660

720

780

069269_0225_SL.TXT caacccaaat ctggctactc cccagaaact aagaaactca tgtcattggc ttacacatca cttacacctc tgctgaatcc actgatctac agtttgagaa acagtgagat gaaaaaagct ttgatgaaac tatggcgaag aagagtggat tcacacacat tctga <210> 1502 <211> 314 <212> PRT

840

900

945

<213> Canis familiaris <400> 1502 Met Lys Arg Gln Asn Gln Ser Ser Val Val Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asn Phe Pro Glu Leu Gln Glu Gln Leu Leu Gly Val Phe Leu 20 25 30 Ala Val Tyr Leu Val Thr Leu Met Gly Asn Ala Ile Ile Ile Val Ile 35 40 45 Ile Ala Leu Glu Gln Thr Leu His Val Pro Met Tyr Leu Phe Leu Gln 50 55 60 Asn Leu Ser Val Val Asp Met Ser Phe Ser Ala Val Ile Met Pro Glu 65 70 75 80 Met Leu Val Val Leu Thr Arg Glu Lys Thr Ser Ile Ser Phe Val Ser

85 90 95

Cys Phe Ala Gln Met Tyr Phe Ile Leu Phe Phe Gly Gly Thr Glu Cys 100 105 110

Phe Leu Leu Gly Thr Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125

Pro Leu Ser Tyr Pro Met Ile Met Asn Lys Arg Val Phe Met Lys Leu 130 135 140

Val Met Phe Ser Trp Val Ser Gly Ile Met Val Ala Thr Val Gln Thr 145 150 155 160

Page 1691

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Thr Trp Val Phe Ser Phe Pro Phe Cys Gly Pro Asn Glu Ile Asn His 165 170 175 Leu Phe Cys Glu Thr Pro Pro Val Leu Glu Leu Ala Cys Ala Asp Thr 180 185 190 Phe Leu Phe Glu Ile Tyr Ala Phe Thr Gly Thr Ile Leu Ile Val Met 195 200 205 Val Pro Phe Val Leu Ile Leu Leu Ser Tyr Ile Arg Ile Leu Phe Ala 210 215 220 Ile Leu Arg Met Pro Ser Ala Thr Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Ser 245 250 255 Met Thr Tyr Leu Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys 260 265 270 Leu Met Ser Leu Ala Tyr Thr Ser Leu Thr Pro Leu Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Ser Glu Met Lys Lys Ala Leu Met Lys Leu 290 295 300 Trp Arg Arg Arg Val Asp Ser His Thr Phe

305 310 <210> 1503 <211> 576 <212> DNA <213> Canis familiaris <400> 1503 ataaaaaatg aaaattaaac tttgatatct gactatattc tcttaggagt gttacccaga atggaaaata tcttttccgt ctctataatt ctccttacat atacaatatg gcccccacag

120

Page 1692

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ggacgtttat cctgattttc ttaatttgga aagattcctg gcttcacaaa tctatatact 180 tcttgtttag ctctcattga tttagctctg atagccactt ctgtttctaa aatgggtatt 240 gactttttct ttggaagaag aaacgtatca cacgctgggt gcaaagttca catctttttc 300 tggacctcgt gatgtcccgg tgtgtccttc tcactcacga ggcttacagt gatgtacata 360 gtgtggctat ttgcttcagg gcacccaccc ttggtgaggt atcagatctt ccaacaactg 420 gcagtagggg cttggtttgg aggatcactg tcttccttgg cccataccgt ctacattttg 480 catttcccca tctgtaaagc taaggaaatt aacctcttcc tgtgtgaggt ccaagttctt 540 ctaaagttct cctatgagaa ccttaatata tataag 576 <210> 1504 <211> 75 <212> PRT <213> Canis familiaris <400> 1504 Met Tyr Ile Val Trp Leu Phe Ala Ser Gly His Pro Pro Leu Val Arg 1 5 10 15 Tyr Gln Ile Phe Gln Gln Leu Ala Val Gly Ala Trp Phe Gly Gly Ser 20 25 30 Leu Ser Ser Leu Ala His Thr Val Tyr Ile Leu His Phe Pro Ile Cys 35 40 45 Lys Ala Lys Glu Ile Asn Leu Phe Leu Cys Glu Val Gln Val Leu Leu 50 55 60 Lys Phe Ser Tyr Glu Asn Leu Asn Ile Tyr Lys 65 70 75 <210> 1505 <211> 576 <212> DNA <213> Canis familiaris <400> 1505 ttaaagaaaa ttatatttgt tctagtttcc aacatctaca tcatttctgt ggtaggaaat 60 gtgctcattg tggccaccat cactgccagc ccgtcatgga ggcctcccat gtaccttttc 120

Page 1693

069269_0225_SL.TXT ctggcctatc tcttctttac tgatggttgc tgttcttcta taaatattcc taaactgatt 180 atagatttac tctatgaaag accatcctat tgaatgagta tatgacctga atctttggag 240 aacatttctt tggagctgct gacaccatcc tacctagtgt gatggcctct gttatgtggc 300 catctgcaag ccgttgcgtt atacaaccat catgcactgg cggatgtgtg gcctgctagt 360 tggagtggtg tgggtgggag gctttcttca tgcaaccaca tagatcctct tcagttctgg 420 ttatccttct ataaccctaa catcacagat cactctatgt gtaatttgaa ccctttgctc 480 aatcttgccc gcacagatac ccaactcttt gttgcagcca acagtggatt gatctatgtg 540 ctaaacttcc ttttctttta aaaagatttc attatt 576 <210> 1506 <211> 70 <212> PRT <213> Canis familiaris <400> 1506

Leu Lys 1 Lys Ile Ile Phe 5 Val Leu Val Ser Asn Ile Tyr Ile Ile Ser 10 15 Val Val Gly Asn Val Leu Ile Val Ala Thr Ile Thr Ala Ser Pro Ser 20 25 30 Trp Arg Pro Pro Met Tyr Leu Phe Leu Ala Tyr Leu Phe Phe Thr Asp 35 40 45 Gly Cys Cys Ser Ser Ile Asn Ile Pro Lys Leu Ile Ile Asp Leu Leu 50 55 60 Tyr Glu Arg Pro Ser Tyr

65 70 <210> 1507 <211> 354 <212> DNA <213> Canis familiaris <400> 1507 ctcatctcaa tgttaatttc cttaatttga ttattatggt attgtggtta tctaagagaa 60

Page 1694

069269_0225_SL.TXT tgcctttatt ttaggaaatt gactgaagta tttaagatgt ctgtaacttg ctctcacttg 120 ttacagaaaa acataatacg ttgtggggtg tctgtgacac tcttctatgg cacagccagt 180 atgacctatt tacaacccaa atctggctat tccccagaaa ctaagaaact catatcattg 240 gcttacacat cacttacacc tctgctgaat ctactgatct acagtttgag aaacagtgag 300 atgaaaaaaa ctttgatgaa actatggcaa agaaaagtgg attcacacac attc 354 <210> 1508 <211> 86 <212> PRT <213> Canis familiaris <400> 1508

Met Ser 1 Val Thr Cys 5 Ser His Leu Leu Gln Lys Asn Ile Ile Arg Cys 10 15 Gly Val Ser Val Thr Leu Phe Tyr Gly Thr Ala Ser Met Thr Tyr Leu 20 25 30 Gln Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys Leu Ile Ser Leu 35 40 45 Ala Tyr Thr Ser Leu Thr Pro Leu Leu Asn Leu Leu Ile Tyr Ser Leu 50 55 60 Arg Asn Ser Glu Met Lys Lys Thr Leu Met Lys Leu Trp Gln Arg Lys 65 70 75 80 Val Asp Ser His Thr Phe

<210> 1509 <211> 939 <212> DNA <213> Canis familiaris <400> 1509 atgcggggac ggaacgccac caaggtcagc gtcttcgtcc tgctgggctt ccccacggcc 60 cctcagctgc agtacgtgct cttcctcgtc ttcctgctca cctacctctt catcctggtg 120 gagaacctgg tcatcatcgt caccgtccgc cgcagcgccc ccctccacag gcccatgtac 180

Page 1695

069269_0225_SL.TXT tacttcctgg gcgccctgtc tgtcctggag gtctggtacg tgtctgacat cgtccccaag atgctggggg ggctcctcct gcagcagaaa ctcatctcct ttgccggctg catgacccag ctctacttct tcagctccct ggtgtgcacc gaatgcgtgc tcctggcctc catggcctac gaccgctacg tggccatctg ccaccccttg cgctaccaag tcatcatgac cacggggctc tgcgtccggc tggtggcctt ctccttcgtc agcggcttct ccatctctgt gatcaaggtg tgctttatct ccagggccac gttttgtggc tccaacgtcc tgaaccactt cttctgtgac atttccccca tcctcaagct ggcctgcacc gacttctcga ccgcggagct ggtggacttc atcctggcct tcatcatcct ggtgtcgccc ctggtggcca ccgtgctgtc ttacgggcac atcaccctgg ccgtcctgcg catcccctcg gccacgggcc gctggagggc cttctccacc tgcgcctccc acctcaccgt ggtcaccatc ttctacacgg ccatgatctt catgtacgtc cggccccagg ccatcgattc ccggagctcc aacaagctca tctctgcggt gtacactgtc ctcaccccga taatcaaccc cttgatctac tgcctgagga acaaagaatt taaggctgcc ttgaaaaagg ctctgggctt tggtccatct tcacggtag <210> 1510 <211> 312 <212> PRT <213> Canis familiaris

240

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540

600

660

720

780

840

900

939

<400> 1510 Met Arg Gly Arg 1 Asn 5 Ala Thr Lys Val Ser Val Phe Val Leu Leu Gly 10 15 Phe Pro Thr Ala Pro Gln Leu Gln Tyr Val Leu Phe Leu Val Phe Leu 20 25 30 Leu Thr Tyr Leu Phe Ile Leu Val Glu Asn Leu Val Ile Ile Val Thr 35 40 45 Val Arg Arg Ser Ala Pro Leu His Arg Pro Met Tyr Tyr Phe Leu Gly 50 55 60 Ala Leu Ser Val Leu Glu Val Trp Tyr Val Ser Asp Ile Val Pro Lys 65 70 75 80

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Met Leu Gly Gly Leu Leu Leu Gln Gln Lys Leu Ile Ser Phe Ala 95 Gly 85 90 Cys Met Thr Gln Leu Tyr Phe Phe Ser Ser Leu Val Cys Thr Glu Cys 100 105 110 Val Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Gln Val Ile Met Thr Thr Gly Leu Cys Val Arg Leu 130 135 140 Val Ala Phe Ser Phe Val Ser Gly Phe Ser Ile Ser Val Ile Lys Val 145 150 155 160 Cys Phe Ile Ser Arg Ala Thr Phe Cys Gly Ser Asn Val Leu Asn His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Ile Leu Lys Leu Ala Cys Thr Asp Phe 180 185 190 Ser Thr Ala Glu Leu Val Asp Phe Ile Leu Ala Phe Ile Ile Leu Val 195 200 205 Ser Pro Leu Val Ala Thr Val Leu Ser Tyr Gly His Ile Thr Leu Ala 210 215 220 Val Leu Arg Ile Pro Ser Ala Thr Gly Arg Trp Arg Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Thr Ile Phe Tyr Thr Ala Met Ile 245 250 255 Phe Met Tyr Val Arg Pro Gln Ala Ile Asp Ser Arg Ser Ser Asn Lys 260 265 270 Leu Ile Ser Ala Val Tyr Thr Val Leu Thr Pro Ile Ile Asn Pro Leu 275 280 285

Page 1697

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Ile Tyr Cys Leu Arg Asn Lys Glu Phe Lys Ala Ala Leu Lys Lys Ala 290 295 300

Leu Gly Phe Gly Pro Ser Ser Arg

305 310 <210> 1511 <211> 951 <212> DNA <213> Canis familiaris <400> 1511

atgccacctc acagtaatgg aaacctctcc atggcctact ttcaagattt tgtgctggaa 60 ggatttggag ttggccttga gacccaggcc ctgctctttg ctgtgttcct ggccctgtat 120 atggtgactg tactgggcaa catcctcatg atcattgtta tcaccctgga tgcccgcctg 180 cactccccaa tgtacttctt cctcaagaac ctctcctttg tggacttgtg ctactcatct 240 gtcattgccc ccaatgcact ggccaacttc ttctcctcgt ccaaggtcat cacctttgca 300 ggatgtgcca tgcagttttc ctttttgtcc ttgctgggca caactgaagc tttcctcctg 360 ggtgtcatgg cctatgaccg cttcatggcc atctgtaacc ccttgcgtta ccccatcacc 420 atgtgccagt ctgcctgcac tcgcctggtg ctgggcgcct actgtggagg ctgcttcaac 480 tctgttgtgc agaccagctt cacattccac ctctcattct gcagctccaa ccgcatcaac 540 cacttcttct gtgatgtgcc ccctctgctc cagatagcct gtggcaacac agccatcaat 600 aaacttctca tgtttggcat ctgtgggttc atgattgtgg gtttggcatt tgtgatcctc 660 atctcctatg gctacatcat agcgaccatc ctgaggatgc agtcaggagc tgggagacgc 720 aagatcttct ccacctgtgg ctcccacatg actgtagtaa ctctcttttt tgggactctc 780 tttgtcatgt atgcccagcc aggagcaatt gagtccatgg agcagggcaa ggtggtctct 840 gtcttctaca cgctggtcat cccaatgctc aatcctctca tctacagtct gcgaaacaag 900 gatgtgaagg aggctgtgca gaggctgggc cagaaacaca tgaccatgta a 951

<210> 1512 <211> 316 <212> PRT

Page 1698

069269_0225_SL.TXT <213> Canis familiaris

<400> 1512 Gly Asn Leu Ser Met Ala Tyr Phe Gln Asp Met 1 Pro Pro His Ser Asn 5 10 15 Phe Val Leu Glu Gly Phe Gly Val Gly Leu Glu Thr Gln Ala Leu Leu 20 25 30 Phe Ala Val Phe Leu Ala Leu Tyr Met Val Thr Val Leu Gly Asn Ile 35 40 45 Leu Met Ile Ile Val Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser 65 70 75 80 Val Ile Ala Pro Asn Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Ala Gly Cys Ala Met Gln Phe Ser Phe Leu Ser Leu Leu 100 105 110 Gly Thr Thr Glu Ala Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125 Met Ala Ile Cys Asn Pro Leu Arg Tyr Pro Ile Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Arg Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Phe Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Ser Phe Cys Ser Ser 165 170 175 Asn Arg Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Gln Ile 180 185 190 Ala Cys Gly Asn Thr Ala Ile Asn Lys Leu Leu Met Phe Gly Ile Cys

Page 1699

195 069269_0225_SL.TXT 200 205 Gly Phe Met Ile Val Gly Leu Ala Phe Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Ile Ala Thr Ile Leu Arg Met Gln Ser Gly Ala Gly Arg Arg 225 230 235 240 Lys Ile Phe Ser Thr Cys Gly Ser His Met Thr Val Val Thr Leu Phe 245 250 255 Phe Gly Thr Leu Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Val Gln Arg Leu Gly Gln Lys His Met Thr Met 305 310 315

<210> 1513 <211> 867 <212> DNA <213> Canis familiaris <400> 1513

aacagctcca tgatccactt tcaagatttt gtactagagg gatttagggg tggtctggag 60 actcaagcca tgctcttcac tgtgctcttg gccctgtata tggtgcctat actgggaaac 120 ttcctcaata tcatctttag catcctggat gcctgcctac acttcccaat gtactacttc 180 ctcaagaacc tctcctttgt ggacttgtgc tactcatctg tcattgcccc atgccaccca 240 gtttttcttt ttatcccttt ggccaccact gaatgcttcc tcctgggtgt tatgttctac 300 gaccgcttca tagccatctg tagccccttg cgctacccca gcaccatgtg ccagtctgcc 360 tgcactcgcc tggtgctggg cgcctactgt ggaggctgct ccaactctgt tgtgcagacc 420 agcttcacat tccacctccc attctgcagc tccaaccgca tcaaccactt cttctgtgat 480

Page 1700

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gtgccccctc tactccagat cgcctgtggc aacacggcca tcaatgaact tctcttattt 540 ggcatctgtg ggctcatgat tgtgggtgtg acatttgttg tcctcatctc ctatggttac 600 ataatagtga ccatcctgag catgggctca ggagctggga gacgcaagat cttctccacc 660 tgtggctccc atatgactgc agtgtctctt tttggggact gtctttgtca tgtatgccca 720 gacaggagca attgagtcca tggagcaggg ctaggtggtc tccgtcttct acacattggt 780 catcccaatg ctcaatccct cacctacaga ctgcaaaaca aggatgtgaa ggaggctgtg 840 tggaggctag gccaggaaca cttggcc 867 <210> 1514 <211> 244 <212> PRT <213> Canis familiaris <400> 1514 Asn Ser Ser Met Ile His Phe Gln Asp Phe Val Leu Glu Gly Phe Arg 1 5 10 15 Gly Gly Leu Glu Thr Gln Ala Met Leu Phe Thr Val Leu Leu Ala Leu 20 25 30 Tyr Met Val Pro Ile Leu Gly Asn Phe Leu Asn Ile Ile Phe Ser Ile 35 40 45 Leu Asp Ala Cys Leu His Phe Pro Met Tyr Tyr Phe Leu Lys Asn Leu 50 55 60 Ser Phe Val Asp Leu Cys Tyr Ser Ser Val Ile Ala Pro Cys His Pro 65 70 75 80 Val Phe Leu Phe Ile Pro Leu Ala Thr Thr Glu Cys Phe Leu Leu Gly 85 90 95 Val Met Phe Tyr Asp Arg Phe Ile Ala Ile Cys Ser Pro Leu Arg Tyr 100 105 110 Pro Ser Thr Met Cys Gln Ser Ala Cys Thr Arg Leu Val Leu Gly Ala

115 120 125

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Tyr Cys 130 Gly Gly Cys Ser His 145 Leu Pro Phe Cys Ser 150 Val Pro Pro Leu Leu 165 Gln Leu Leu Leu Phe 180 Gly Ile Val Val Leu 195 Ile Ser Tyr Gly Ser 210 Gly Ala Gly Arg Met 225 Thr Ala Val Ser Leu 230 Asp Arg Ser Asn

Asn 135 Ser Val Val Gln Ser Asn Arg Ile Asn 155 Ile Ala Cys Gly 170 Asn Cys Gly Leu 185 Met Ile Gly Tyr 200 Ile Ile Val Arg 215 Lys Ile Phe Ser Phe Gly Asp Cys Leu 235

Thr 140 Ser Phe Thr Phe His Phe Phe Cys Asp 160 Thr Ala Ile Asn 175 Glu Val Gly Val 190 Thr Phe Thr Ile 205 Leu Ser Met Thr 220 Cys Gly Ser His Cys His Val Cys Pro 240

<210> 1515 <211> 951 <212> DNA <213> Canis familiaris <400> 1515 atgccatccc acagttatgg ggattttcag gtggtctgga atggtgactg tgctgggcaa cactccccaa tgtacttctt ttcattgccc ccaatgcact ggatgtgcca tgcagttttt aaacctctcc aaggtctact aacccaggcg ctgctctttg cctcctcatg atcattgtta cctcaagaac ctctccttcg ggccaacttc ttctcctcgt ctttttgtcc attctggcca ttcaagattt tgtgctggag ctgtgttcct ggccctgtac tcaccctgga tgcccgcctg tggacttgtg gtactcatct ccaaggtcat caccttcaca ccactgaatg cttcctcctg

120

180

240

300

360

Page 1702

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ggtgtcatgg cctatgaccg cttcatggcc atctgtaacc ccttgcgcta ccccatcacc 420 atgtgccagt ctgcctgcac tcgcctggtg ctgggcgcct actgtggagg ctgcttcaac 480 tctattgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccgcatcaac 540 cacttcttct gtgatgtgcc ccctctactc cagatcgcct gtggcaacat agccatcaat 600 aaacttctct tgtttggcat ctgtgggctc atcattgtgg gtgtgatgtt tgtgatcctc 660 atctcctatg gctacatcat agcgaccatc ctgaggatgc ggtcaggagc tgggagacgc 720 aagatcttct ccacctgtgg ctcccacatg actgcagtga ctctcttttt tgggactctc 780 tttgtcatgt atgcccagcc aggagcaatt gagtccatgg agcagggcaa ggtggtctct 840 gtcttctaca cgctggtcat cccaatgctc aatcccctca tctacagtct gcgaaacaag 900 gatgtgaagg aggctgtgca gaggctgggc cagaaacaca tgaccatgtg a 951 <210> 1516 <211> 316 <212> PRT <213> Canis familiaris <400> 1516 Met Pro Ser His Ser Tyr Gly Asn Leu Ser Lys Val Tyr Phe Gln Asp 1 5 10 15 Phe Val Leu Glu Gly Phe Ser Gly Gly Leu Glu Thr Gln Ala Leu Leu 20 25 30 Phe Ala Val Phe Leu Ala Leu Tyr Met Val Thr Val Leu Gly Asn Leu 35 40 45 Leu Met Ile Ile Val Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Trp Tyr Ser Ser 65 70 75 80 Phe Ile Ala Pro Asn Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Thr Gly Cys Ala Met Gln Phe Phe Phe Leu Ser Ile Leu

Page 1703

100

069269_0225_SL.TXT 105 110

Ala Thr Thr 115 Glu Cys Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 120 125 Met Ala Ile Cys Asn Pro Leu Arg Tyr Pro Ile Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Arg Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Phe Asn 145 150 155 160 Ser Ile Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser Ser 165 170 175 Asn Arg Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Gln Ile 180 185 190 Ala Cys Gly Asn Ile Ala Ile Asn Lys Leu Leu Leu Phe Gly Ile Cys 195 200 205 Gly Leu Ile Ile Val Gly Val Met Phe Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Ile Ala Thr Ile Leu Arg Met Arg Ser Gly Ala Gly Arg Arg 225 230 235 240 Lys Ile Phe Ser Thr Cys Gly Ser His Met Thr Ala Val Thr Leu Phe 245 250 255 Phe Gly Thr Leu Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Val Gln Arg Leu Gly Gln Lys His Met Thr Met

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305 310 315 <210> 1517 <211> 969 <212> DNA <213> Canis familiaris <400> 1517

atgccatccc acagtaatga aaacctctcc atggtctact ttcaagattt tgtgctggag 60 ggatttgggg gtggcctgga gacccaggcg ctactcttca cactgtttct ggccctgtac 120 atggtgactc tgctggggaa cattctcatg atcatcataa ttaccctgga tgcccgcctg 180 cactccccaa tgtacttctt cctcaagaac ctctccttcg tggacttgtg ctactcatct 240 gtgatcgccc ccaatgcact ggccaacttc ttctcctcat ccaaggtcat cacctttgca 300 ggatgtgcca cccagttttt ctttatctcc ctgctggcca ccactgaatg cttcttcctg 360 ggtgtgatgg cgtatgaccg cttcatggcc atctgtagcc ctttgcgcta cccaagtacc 420 atgtgccagt ctgcctgcac tcgcctggtg ctgggcgcct actgtggagg ctgcttcaac 480 tctgttgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccgcatcaac 540 cacttcttct gtgatgtgcc ccctctgctc cagatcgcct gtggcaacac ggccatcaat 600 gaacttcttc tgtttggcat ctgtgggctc atcattgtgg gtgtgatgtt tgtgatcctc 660 atctcctatg gctacatcac agtgaccatc ctgaggatgc ggtcaggaac tgggagacac 720 aagatcttct ccacctgtgg ctcccacatg actgtagtga ctctcttttt tgggactgcc 780 tttgtcatgt atgcccagcc aggagcaatt gaatccatgg agcagggcaa ggtggtctct 840 gtcttctaca cgctggtcat cccaatgctc aatcccctca tctacagtct gcgaaacaag 900 gatgtgaagg aggctgtgca gaggctgggc cagaaacaca tggccatacg aaggatgtgc 960

tgttggtag 969 <210> 1518 <211> 322 <212> PRT <213> Canis familiaris <400> 1518

Met Pro Ser His Ser Asn Glu Asn Leu Ser Met Val Tyr Phe Gln Asp 1 5 10 15

Page 1705

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Phe Val Leu Glu 20 Gly Phe Gly Gly Gly Leu Glu Thr Gln Ala Leu Leu 25 30 Phe Thr Leu Phe Leu Ala Leu Tyr Met Val Thr Leu Leu Gly Asn Ile 35 40 45 Leu Met Ile Ile Ile Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser 65 70 75 80 Val Ile Ala Pro Asn Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Ala Gly Cys Ala Thr Gln Phe Phe Phe Ile Ser Leu Leu 100 105 110 Ala Thr Thr Glu Cys Phe Phe Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125 Met Ala Ile Cys Ser Pro Leu Arg Tyr Pro Ser Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Arg Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Phe Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser Ser 165 170 175 Asn Arg Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Gln Ile 180 185 190 Ala Cys Gly Asn Thr Ala Ile Asn Glu Leu Leu Leu Phe Gly Ile Cys 195 200 205 Gly Leu Ile Ile Val Gly Val Met Phe Val Ile Leu Ile Ser Tyr Gly 210 215 220

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Tyr 225 Ile Thr Val Thr Ile Leu Arg Met Arg Ser Gly Thr Gly Arg His 230 235 240 Lys Ile Phe Ser Thr Cys Gly Ser His Met Thr Val Val Thr Leu Phe 245 250 255 Phe Gly Thr Ala Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Val Gln Arg Leu Gly Gln Lys His Met Ala Ile Arg Arg Met Cys 305 310 315 320

Cys Trp <210> 1519 <211> 951 <212> DNA <213> Canis familiaris <400> 1519

atgccatccc acagtaatga aaacctctcc aaggtctaca ttcaagattt tgtgctggag 60 ggatttgggg gtggcctgga gacccaggtg ctactcttca ctctgtttct ggccctgtac 120 atggtgactc tgctggggaa cattctcatg atcatcataa ttaccctgga tgcccgcctg 180 cactccccaa tgtacttctt cctcaagaac ctctccttcg tggacttgtg ctactcatct 240 gtgatcgccc ccaatgcact ggccaacttc ttctcctcat ccaaggtcat cacctttgca 300 ggatgtgcca cccagttttt ctttttctcc ctcctggcca gcactgaatg cttcctcctg 360 ggtgtcatgg cctatgaccg cttcatggcc atctgtaacc ccttacatta ccccagcacc 420 atgtgccagt ctgcctgcac tcgcctggtg ctgggcacct attgtggagg ctgcctcaac 480

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tctgttgtgc agaccagctt cacattccac ctctcattct gcagctccaa ccgcatcaac 540 cacttcttct gtgatgtgcc ccctctgctc ctgatcgcct gtggcaacac ggccatcaat 600 gaacttcttc tgtttggcat ctgtgggctc atcattgtgg gtgtgacatt tgtgatcctc 660 atctcctatg gctacatcac agtgaccatc ctgaggatgc ggtcaggagc tgggagacgc 720 aagatcttct ccacctgtgg ctcccacatg actgcagtga ccctcttttt tgggactctc 780 tttgtcatgt atgcccagcc aggagcaatt gagtccatgg agcagggcaa ggtggtctct 840 gtcttctaca cgctggtcat cccaatgctc aatcctctca tctacagtct gcgaaacaag 900 gatgtgaagg aagctgtgca gaggttgggc cagaaacaca cagtcacgtg a 951

<210> 1520 <211> 316 <212> PRT <213> Canis familiaris

<400> 1520 Asn Glu Asn Leu Ser Lys Val Tyr Ile Gln Asp Met 1 Pro Ser His Ser 5 10 15 Phe Val Leu Glu Gly Phe Gly Gly Gly Leu Glu Thr Gln Val Leu Leu 20 25 30 Phe Thr Leu Phe Leu Ala Leu Tyr Met Val Thr Leu Leu Gly Asn Ile 35 40 45 Leu Met Ile Ile Ile Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser 65 70 75 80 Val Ile Ala Pro Asn Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Ala Gly Cys Ala Thr Gln Phe Phe Phe Phe Ser Leu Leu 100 105 110 Ala Ser Thr Glu Cys Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe Page 1708

115 069269_0225_SL.TXT 120 125 Met Ala Ile Cys Asn Pro Leu His Tyr Pro Ser Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Arg Leu Val Leu Gly Thr Tyr Cys Gly Gly Cys Leu Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Ser Phe Cys Ser Ser 165 170 175 Asn Arg Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Leu Ile 180 185 190 Ala Cys Gly Asn Thr Ala Ile Asn Glu Leu Leu Leu Phe Gly Ile Cys 195 200 205 Gly Leu Ile Ile Val Gly Val Thr Phe Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Thr Val Thr Ile Leu Arg Met Arg Ser Gly Ala Gly Arg Arg 225 230 235 240 Lys Ile Phe Ser Thr Cys Gly Ser His Met Thr Ala Val Thr Leu Phe 245 250 255 Phe Gly Thr Leu Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Val Gln Arg Leu Gly Gln Lys His Thr Val Thr 305 310 315

<210> 1521

Page 1709

069269_0225_SL.TXT <211> 951 <212> DNA <213> Canis familiaris <400> 1521

atgccatccc acagtaatga aaatctctct aaggtctaca ttcaagattt tgtgctggag 60 ggatttgggg gtggcctgga gacccaggcg ctactcttca ctctgtttct ggccctgtac 120 atggtgactc ttctggggaa catcctcatg atcatcataa ttaccctgga tgcccgcctg 180 cactccccaa tgtacttctt cctcaagaac ctctccttcg tggacttgtg ctactcatct 240 gtcattgccc ccaatgcact ggccaacttc ttctcctcat ccaaggtcat cacctttgca 300 ggatgtgcca cccagttttt ctttatctcc cttatggcaa ccactgaatg cttcctcctg 360 ggtgtcatgg cgtatgaccg cttcatggcc atctgtagcc ctttgcgcta cccgagcacc 420 atgtgccagt ctgcctgcac tcgcctggtg ctgggcgcct actgtggagg ctgcttcaac 480 tctgttgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccacatcaac 540 cacttcttct gtgatgtgcc ccctctgctc cagatcgcct gtggcaacac ggccatcaat 600 gaacttctct tgtttggcat ctgtgggctc atcattgtgg gtgtgacgtt tgtgatcctc 660 atctcctatg gctacatcac agtgaccatc ctgaggatgg gatcaggagc tgggagacac 720 aagatcttct ccacctgtgg ctcccacatg actgcagtga ctctcttttt tgggactctc 780 tttgtcatgt atgcccagcc aggagcaatt gagtccatgg agcagggcaa ggtggtctct 840 gtcttctaca cgctggtcat cccaatgctc aatcctctca tctacagtct gcgaaacaag 900 gatgtgaagg aggctgtgca gaggctgggc cagaaacaca cagtcatgtg a 951

<210> 1522 <211> 316 <212> PRT <213> Canis familiaris <400> 1522

Met Pro Ser His Ser Asn Glu Asn Leu Ser Lys Val Tyr Ile Gln Asp 1 5 10 15 Phe Val Leu Glu Gly Phe Gly Gly Gly Leu Glu Thr Gln Ala Leu Leu 20 25 30

Page 1710

Phe Thr Leu 35 Phe Leu Ala Leu 069269_0225_SL.TXT Tyr Met Val Thr Leu Leu 40 45 Gly Asn Ile Leu Met Ile Ile Ile Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser 65 70 75 80 Val Ile Ala Pro Asn Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Ala Gly Cys Ala Thr Gln Phe Phe Phe Ile Ser Leu Met 100 105 110 Ala Thr Thr Glu Cys Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125 Met Ala Ile Cys Ser Pro Leu Arg Tyr Pro Ser Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Arg Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Phe Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser Ser 165 170 175 Asn His Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Gln Ile 180 185 190 Ala Cys Gly Asn Thr Ala Ile Asn Glu Leu Leu Leu Phe Gly Ile Cys 195 200 205 Gly Leu Ile Ile Val Gly Val Thr Phe Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Thr Val Thr Ile Leu Arg Met Gly Ser Gly Ala Gly Arg His 225 230 235 240

Page 1711

Lys Ile Phe Ser Thr 245 Cys Gly 069269_0225_SL.TXT Ser His Met Thr Ala Val 250 Thr Leu 255 Phe Phe Gly Thr Leu Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Val Gln Arg Leu Gly Gln Lys His Thr Val Met 305 310 315

<210> 1523 <211> 951 <212> DNA <213> Canis familiaris <400> 1523

atgccatccc acagtaatgg aaaccactcc aaggtctact ttcaagattt tgtgctggag 60 ggatttgcag gtggccttga gacccaggcc ctgctctttg ctgttttcct ggccctgtac 120 atggtgactg tcctgggtaa cctcctcatg atcatcgtta tcaccctgga tgcccgcctg 180 cactccccaa tgtacttctt cctcaagaac ctctcctttg tggacttgtg ctactcatct 240 gtcattgccc ccaatgcact ggccaacttc ttctcctcat ccaaggtcat cacctttgca 300 ggatgtgcca cccagttttt ctttttatcc ctgctggcca caactgaagg cttcctcctg 360 ggtgtcatgg cctacgaccg cttcatggct atctgtagcc ccttgcgtta ccccaccacc 420 atgtgccagt ctgcctgcac tcgcctggtg ctgggcgcct actgtggagg ctgcttcaac 480 tctgttgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccgcatcaac 540 cacttcttct gtgatgtgcc ccctctgctc cagatcgcct gtggcaacac ggccatcaat 600 gaacttctct tgtttggcat ctgtgggctc atcatagtgg ctgtgacgat tgtgatcctc 660 atctcctatg gctacatcac agtgaccatc ctgaggatgg gatcaggagc tgggagacgc 720 aagatcttct ccacctgtgg ctcccacatg actgcagtga ctctcttttt tgggactctc 780

Page 1712

069269_0225_SL.TXT tttgtcatgt atgcccagcc aggagcaatt gagtccatgg agcagggcaa ggtggtctct gtcttctaca cgctggtcat cccaatgctc aatcccctca tctacagtct gcgaaacaag gatgtgaagg aggccctgcg gaggctgggc cagaagcaca cggccatgtg a

840

900

951 <210> 1524 <211> 316 <212> PRT <213> Canis familiaris

<400> 1524 Asn Gly Asn His Ser Lys Val Tyr Phe Gln Asp Met Pro 1 Ser His Ser 5 10 15 Phe Val Leu Glu Gly Phe Ala Gly Gly Leu Glu Thr Gln Ala Leu Leu 20 25 30 Phe Ala Val Phe Leu Ala Leu Tyr Met Val Thr Val Leu Gly Asn Leu 35 40 45 Leu Met Ile Ile Val Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser 65 70 75 80 Val Ile Ala Pro Asn Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Ala Gly Cys Ala Thr Gln Phe Phe Phe Leu Ser Leu Leu 100 105 110 Ala Thr Thr Glu Gly Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125 Met Ala Ile Cys Ser Pro Leu Arg Tyr Pro Thr Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Arg Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Phe Asn 145 150 155 160

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Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser 175 Ser 165 170 Asn Arg Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Gln Ile 180 185 190 Ala Cys Gly Asn Thr Ala Ile Asn Glu Leu Leu Leu Phe Gly Ile Cys 195 200 205 Gly Leu Ile Ile Val Ala Val Thr Ile Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Thr Val Thr Ile Leu Arg Met Gly Ser Gly Ala Gly Arg Arg 225 230 235 240 Lys Ile Phe Ser Thr Cys Gly Ser His Met Thr Ala Val Thr Leu Phe 245 250 255 Phe Gly Thr Leu Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Leu Arg Arg Leu Gly Gln Lys His Thr Ala Met 305 310 315

<210> 1525 <211> 951 <212> DNA <213> Canis familiaris <400> 1525 atgccattgc acaataatgg aaacctctcc aaggtctact ttcaagattt tgtgctggag ggatttgcag gtggccttag gacccaggcc ctgctctttg ctgtgttcct tgccctgtac atggtgactg tgctgggtaa cctcctcatg atcatcgtta tcaccctgga tgcccgcctg

120

180

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cactccccaa tgtacttctt tctcaagaac ctctcctttg tggacttgtg ctactcatct 240 gtcattgccc caaatgcact ggccaacttc ttctcctcgt ccaaggtcat cacctttgca 300 ggatgtgcca cccagttttt ctttttctcc ttgctggcca caactgaagg cttcctcctg 360 ggtgtcatgg cctatgaccg cttcatggcc atctgtaacc ccttgcgtta ccccatcacc 420 atgtgccagt ctgcctgcac tcgcctgctg ctgggtgcct actgtggagg ctgcttcaac 480 tctgttgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccgcatcaac 540 cacttcttct gtgatgtgcc ccctctgctc cagatcgcct gtggcaacac ggccatcaat 600 gaacttctct tgtttggcat ctgtgggctc atcatagtgg ctgtgacgat tgtgatcctc 660 atctcctatg gctacatcac agtgaccatc ctgaggatgc gctcaggaac tgggagacgc 720 aagatcttct ccacctgtgg ctcccacatg actgcagtga ctctcttttt tgggactctc 780 tttgtcatgt atgcccagcc aggagcaatt gagtccatgg agcagggcaa ggtggtctct 840 gtcttctaca cgctggtcat cccaatgctc aatcccctca tctacagtct acgaaacaag 900 gatgtgaagg aggccctgcg gaggctgggc cagaagcaca cgaccatgtg a 951 <210> 1526 <211> 316 <212> PRT <213> Canis familiaris <400> 1526 Met Pro Leu His Asn Asn Gly Asn Leu Ser Lys Val Tyr Phe Gln Asp 1 5 10 15 Phe Val Leu Glu Gly Phe Ala Gly Gly Leu Arg Thr Gln Ala Leu Leu 20 25 30 Phe Ala Val Phe Leu Ala Leu Tyr Met Val Thr Val Leu Gly Asn Leu 35 40 45 Leu Met Ile Ile Val Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser 65 70 75 80

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Val Ile Ala Pro Asn 85 Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 90 95 Ile Thr Phe Ala Gly Cys Ala Thr Gln Phe Phe Phe Phe Ser Leu Leu 100 105 110 Ala Thr Thr Glu Gly Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125 Met Ala Ile Cys Asn Pro Leu Arg Tyr Pro Ile Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Arg Leu Leu Leu Gly Ala Tyr Cys Gly Gly Cys Phe Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser Ser 165 170 175 Asn Arg Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Gln Ile 180 185 190 Ala Cys Gly Asn Thr Ala Ile Asn Glu Leu Leu Leu Phe Gly Ile Cys 195 200 205 Gly Leu Ile Ile Val Ala Val Thr Ile Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Thr Val Thr Ile Leu Arg Met Arg Ser Gly Thr Gly Arg Arg 225 230 235 240 Lys Ile Phe Ser Thr Cys Gly Ser His Met Thr Ala Val Thr Leu Phe 245 250 255 Phe Gly Thr Leu Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285

Page 1716

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Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Leu Arg Arg Leu Gly Gln Lys His Thr Thr Met

305 310 315 <210> 1527 <211> 966 <212> DNA <213> Canis familiaris <400> 1527

atgccatcct acagtaatgg aaacctctcc atggtctacc ttcaagattt tgtgctggag 60 ggatttgaag gtggtctgga gacccaggcc ctgctctttg ctgtgttcct ggccctgtac 120 atggtgactg tcctgggtaa cctcctcatg atcatcgtta tcaccctgga tgcccgactg 180 cactccccaa tgtacttctt cctcaagaac ctctccttcc tggacttgtg ctactcatct 240 gtcatcgccc ccaatgcact ggccaacttc ttctcctcat ccaaggtcat cacctttaca 300 ggatgtgcca cccagttatt ctttttctcc ctgctggtca caactgaagg tttcctcttg 360 ggtgtcatgg cctatgaccg cttcatggcc atctgtagcc ccttgcgcta ccccatcacc 420 atgtgccagt ctgcctgcac tcgcctggtg ctgggcgcct actgtggagg ctgcctcaac 480 tctgttgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccgcatcaac 540 catttcttct gtgatgtgcc ccctctgctc cagatcgcct gtggcaacac ggccatcaat 600 gaacttctct tgtttggcat ctgtgggctc atcatagtgg ctgtgacgat tgtgatcctc 660 atctcctatg gctacatcac agtgaccatc ctgaggatgc ggtcaggagc tgggagacgc 720 aagatcttct ccacctgtgg ctcccacatg actgcagtga ccctattttt tggggactgt 780 ttttttttgg ggactgtttt tgtcatgtat gcccagccag gagcaattga gtccatggag 840 cagggcaagg tagtctctgt cttctacacg ctggtcatcc caatgctcaa tcccctcatc 900 tacagtctgc gaaacaagga tgtgaaggag gccctgcgga ggctgggcca gaaacacacg 960

gccatg 966 <210> 1528

Page 1717

069269_0225_SL.TXT <211> 322 <212> PRT <213> Canis familiaris

<400> 1528 Tyr Leu Gln 15 Asp Met 1 Pro Ser Tyr Ser Asn Gly Asn 5 Leu Ser 10 Met Val Phe Val Leu Glu Gly Phe Glu Gly Gly Leu Glu Thr Gln Ala Leu Leu 20 25 30 Phe Ala Val Phe Leu Ala Leu Tyr Met Val Thr Val Leu Gly Asn Leu 35 40 45 Leu Met Ile Ile Val Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Leu Asp Leu Cys Tyr Ser Ser 65 70 75 80 Val Ile Ala Pro Asn Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Thr Gly Cys Ala Thr Gln Leu Phe Phe Phe Ser Leu Leu 100 105 110 Val Thr Thr Glu Gly Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125 Met Ala Ile Cys Ser Pro Leu Arg Tyr Pro Ile Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Arg Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Leu Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser Ser 165 170 175 Asn Arg Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Gln Ile 180 185 190

Page 1718

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Ala Cys Gly 195 Asn Thr Ala Ile Asn Glu Leu Leu Leu Phe Gly Ile Cys 200 205 Gly Leu Ile Ile Val Ala Val Thr Ile Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Thr Val Thr Ile Leu Arg Met Arg Ser Gly Ala Gly Arg Arg 225 230 235 240 Lys Ile Phe Ser Thr Cys Gly Ser His Met Thr Ala Val Thr Leu Phe 245 250 255 Phe Gly Asp Cys Phe Phe Leu Gly Thr Val Phe Val Met Tyr Ala Gln 260 265 270 Pro Gly Ala Ile Glu Ser Met Glu Gln Gly Lys Val Val Ser Val Phe 275 280 285 Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg 290 295 300 Asn Lys Asp Val Lys Glu Ala Leu Arg Arg Leu Gly Gln Lys His Thr 305 310 315 320

Ala Met <210> 1529 <211> 939 <212> DNA <213> Canis familiaris <400> 1529 atgcggggac ggaacgccac caaggtcagc gtcttcgtcc tgctgggctt ccccacggcc cctcggctgc agtacgtgct cttcctcgtc ttcctgctca cctacctctt catcctggtg gagaacctcg tcatcatcgt caccgtccgc cgcagcgccc ccctccacag gcccatgtac tacttcctgg gcgccctgtc tgtcctggag gtctggtacg tgtcggtcat catccccaag atgctggggg ggctcctcct gcagcagaaa ctcatctcct ttgccggctg catgacccag

120

180

240

300

Page 1719

069269_0225_SL.TXT

ctctacttct tcagctccct ggtgtgcacc gaatgcgtgc tcctggcctc catggcctac 360 gaccgctacg tggccatctg ccaccccctg cgctaccaag tcatcatgac cacgaggctc 420 tgcgtccggc tggtggcctt ctccttcgtc agcggcttct ccatctctat gatcaaggtg 480 ttctttgtct ccagggccac gttctgtggc tccaacgtcc tgaaccactt cttctgtgac 540 atttccccca tcctcaagct ggcctgcacc gacttctcga ccgcggagct ggtggacttc 600 atcctggcct tcatcatcct ggtgtcgccc ctggtggcca ccgtgctgtc ctacgggcac 660 atcaccctgg ccgtcctgcg catcccctcg gccacgggcc gctggagggc cttctccacc 720 tgcgcctccc acctcaccgt ggtcaccatc ttctacacgg ccatgatctt catgtacgtc 780 cggccccagg ccatcgattc ccggagctcc aataagctca tctctgcggt gtacactgtc 840 ctcaccccga taatcaaccc cttgatctac tgcctgagga acaaagaatt taaggctgcc 900 ttgaaaaagg ctctgggctt tggtcaaatt cccacatag 939

<210> 1530 <211> 313 <212> PRT <213> Canis familiaris

<400> 1530 Leu Thr 5 Lys Ala Gln Ser Leu Phe Gln Gly Ser Leu Leu Cys 1 Gly Asn 10 15 Lys Phe Phe Val Pro Gln Ala Val Asp Gln Gly Val Asp Tyr Arg Gly 20 25 30 Glu Asp Ser Val His Arg Arg Asp Glu Leu Ile Gly Ala Pro Gly Ile 35 40 45 Asp Gly Leu Gly Pro Asp Val His Glu Asp His Gly Arg Val Glu Asp 50 55 60 Gly Asp His Gly Glu Val Gly Gly Ala Gly Gly Glu Gly Pro Pro Ala 65 70 75 80 Ala Arg Gly Arg Gly Asp Ala Gln Asp Gly Gln Gly Asp Val Pro Val 85 90 95

Page 1720

069269_0225_SL.TXT

Gly Gln His Gly 100 Gly His Gln Gly Arg His Gln Asp Asp Glu Gly Gln 105 110 Asp Glu Val His Gln Leu Arg Gly Arg Glu Val Gly Ala Gly Gln Leu 115 120 125 Glu Asp Gly Gly Asn Val Thr Glu Glu Val Val Gln Asp Val Gly Ala 130 135 140 Thr Glu Arg Gly Pro Gly Asp Lys Glu His Leu Asp His Arg Asp Gly 145 150 155 160 Glu Ala Ala Asp Glu Gly Glu Gly His Gln Pro Asp Ala Glu Pro Arg 165 170 175 Gly His Asp Asp Leu Val Ala Gln Gly Val Ala Asp Gly His Val Ala 180 185 190 Val Val Gly His Gly Gly Gln Glu His Ala Phe Gly Ala His Gln Gly 195 200 205 Ala Glu Glu Val Glu Leu Gly His Ala Ala Gly Lys Gly Asp Glu Phe 210 215 220 Leu Leu Gln Glu Glu Pro Pro Gln His Leu Gly Asp Asp Asp Arg His 225 230 235 240 Val Pro Asp Leu Gln Asp Arg Gln Gly Ala Gln Glu Val Val His Gly 245 250 255 Pro Val Glu Gly Gly Ala Ala Ala Asp Gly Asp Asp Asp Asp Glu Val 260 265 270 Leu His Gln Asp Glu Glu Val Gly Glu Gln Glu Asp Glu Glu Glu His 275 280 285 Val Leu Gln Pro Arg Gly Arg Gly Glu Ala Gln Gln Asp Glu Asp Ala 290 295 300

Page 1721

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Asp Leu Gly Gly Val Pro Ser Pro His 305 310 <210> 1531 <211> 951 <212> DNA <213> Canis familiaris <400> 1531

atgccaccca aaagaaatgg aaacctctcc atggtccact ttcaagattt tgttctggag 60 ggatttgagg gtggcctgga gacccaggcc ctgctctttg ctgtgttcct ggctctatac 120 atggtgactg tactgggtaa cctcctcatg atcatcgtta tcaccctgga tgcccgcctg 180 cactccccaa tgtacttctt cctcaagaac ctctccttcg ttgacttgtg ctactcatct 240 gtcattgccc ccaaagcact ggccaacttc ttctcctcat ccaaggtcat cacctttgca 300 ggatgtgcca tgcagttttt ctttttctcc ttgctgggca caactggagc tttcctcctg 360 ggtgtcatgg cctatgaccg cttcatggcc atctgtaacc ccttgcgtta ccccatcacc 420 atgtgccagt ctgcctgcac ttgcctggtg ctgggcgcct actgtggagg gtgcttcaac 480 tctgttgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccgcatcaac 540 cacttcttct gtgatgtggt ccccttgctc aaactctcct gtggcaacac agccatcaat 600 gaacttctct tgtttggcat ctgtgggctc atcattgtgg gtttggcatt tatggtcctc 660 atctcctatg gctacatcat agtgaccatc ctgaggatgg gatcaggagc taggagacgt 720 aaggtcttct ctacctgtgg ctcccacatg actgcagtga ctctcttttt tgggaccgtc 780 tttgtcatgt atgcccagcc aggagcaatt gagtctatgg agcagggcaa ggtggtctct 840 gtcttctaca cgctggtcat cccaatgctc aatcccctca tctacagtct gcgaaacaag 900 gatgtgaagg aggccctgcg gaggctgggc cagaaaccca tggccttgtg a 951

<210> 1532 <211> 316 <212> PRT <213> Canis familiaris <400> 1532

Met Pro Pro Lys Arg Asn Gly Asn Leu Ser Met Val His Phe Gln Asp

Page 1722

0 6926 i9_02 25_S iL.TX T 1 5 10 15 Phe Val Leu Glu Gly Phe Glu Gly Gly Leu Glu Thr Gln Ala Leu Leu 20 25 30 Phe Ala Val Phe Leu Ala Leu Tyr Met Val Thr Val Leu Gly Asn Leu 35 40 45 Leu Met Ile Ile Val Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser 65 70 75 80 Val Ile Ala Pro Lys Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Ala Gly Cys Ala Met Gln Phe Phe Phe Phe Ser Leu Leu 100 105 110 Gly Thr Thr Gly Ala Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125 Met Ala Ile Cys Asn Pro Leu Arg Tyr Pro Ile Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Cys Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Phe Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser Ser 165 170 175 Asn Arg Ile Asn His Phe Phe Cys Asp Val Val Pro Leu Leu Lys Leu 180 185 190 Ser Cys Gly Asn Thr Ala Ile Asn Glu Leu Leu Leu Phe Gly Ile Cys 195 200 205 Gly Leu Ile Ile Val Gly Leu Ala Phe Met Val Leu Ile Ser Tyr Gly

Page 1723

210 215 069269_0225_SL.TXT 220 Tyr Ile Ile Val Thr Ile Leu Arg Met Gly Ser Gly Ala Arg Arg Arg 225 230 235 240 Lys Val Phe Ser Thr Cys Gly Ser His Met Thr Ala Val Thr Leu Phe 245 250 255 Phe Gly Thr Val Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Leu Arg Arg Leu Gly Gln Lys Pro Met Ala Leu 305 310 315

<210> 1533 <211> 951 <212> DNA <213> Canis familiaris <400> 1533

atgccaccca aaagaaatgg aaacctctcc atggtccact ttcaagattt tgtgctggag 60 ggatttgaag gtggcctgga aacccaggcc ctgctctttg ctgtgttcct ggctctatac 120 atggtgactg tactgggtaa cctcctcatg atcatcgtta tcaccctgga tgcccgcctg 180 cactccccaa tgtacttctt cctcaagaac ctctccttcg ttgacttgtg ctactcatct 240 gtcattgccc ccaaagcact ggccaacttc ttctcctcat ccaaggtcat cacctttgca 300 ggatgtgcca tgcagttttc ctttttgtcc ttgctgggca caactgaagc tttcctcctg 360 ggtgtcatgg cctatgaccg cttcatggcc atctgtaacc ccttgcgtta ccccatcacc 420 atgtgccagt ctgcctgcac tcgcctggtg ctgggcgcct actgtggagg ctgcttcaac 480 tctgttgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccgcatcaac 540 cacttcttct gtgatgtggt ccccttgctc aaactctcct gtggcaacac ggccatcaat 600

Page 1724

069269_0225_SL.TXT gaacttctct tgtttggcat ctgtgggctc atcatcgtga gcgtgacatt tgtgattctc atctcctatg gctacatcat agcgaccatc ctgaggatgg gatcaggagc tgggagaagc aagatcttct ccacctgtgg ctcccacatg actgcagtga ctctcttttt tgggactgcc tttttcatgt atgcccagcc acgagcaatt gagtctatgg agcagggcaa ggtggtctct gtcttctaca cgctggtcat cccaatgctc aatcccctca tctacagtgt gcgaaacaag gatgtgaagg aggccctgcg gaggctgggc cagaaacaca cggccacgtg a

660

720

780

840

900

951 <210> 1534 <211> 316 <212> PRT <213> Canis familiaris

<400> 1534 Asn Gly Asn Leu Ser Met Val His Phe Gln Asp Met 1 Pro Pro Lys Arg 5 10 15 Phe Val Leu Glu Gly Phe Glu Gly Gly Leu Glu Thr Gln Ala Leu Leu 20 25 30 Phe Ala Val Phe Leu Ala Leu Tyr Met Val Thr Val Leu Gly Asn Leu 35 40 45 Leu Met Ile Ile Val Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser 65 70 75 80 Val Ile Ala Pro Lys Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Ala Gly Cys Ala Met Gln Phe Ser Phe Leu Ser Leu Leu 100 105 110 Gly Thr Thr Glu Ala Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125

Page 1725

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Met Ala 130 Ile Cys Asn Pro Leu Arg Tyr Pro Ile Thr Met Cys Gln Ser 135 140 Ala Cys Thr Arg Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Phe Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser Ser 165 170 175 Asn Arg Ile Asn His Phe Phe Cys Asp Val Val Pro Leu Leu Lys Leu 180 185 190 Ser Cys Gly Asn Thr Ala Ile Asn Glu Leu Leu Leu Phe Gly Ile Cys 195 200 205 Gly Leu Ile Ile Val Ser Val Thr Phe Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Ile Ala Thr Ile Leu Arg Met Gly Ser Gly Ala Gly Arg Ser 225 230 235 240 Lys Ile Phe Ser Thr Cys Gly Ser His Met Thr Ala Val Thr Leu Phe 245 250 255 Phe Gly Thr Ala Phe Phe Met Tyr Ala Gln Pro Arg Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Val Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Leu Arg Arg Leu Gly Gln Lys His Thr Ala Thr

305 310 315 <210> 1535 <211> 951 <212> DNA <213> Canis familiaris

Page 1726

069269_0225_SL.TXT <400> 1535

atgctatccc acagaaatgg aaacctctcc atggtctact ttcaagattt tgttctggag 60 ggatttgaaa gtggcctgga aacccaggcc ctgctctttg ctgtgttcct ggccctgtat 120 atggtgactg tactgggcaa cttcctcatg atcatcgtta tcaccctgga ttcccacctg 180 cactccccaa tgtacttctt cctcaagaac ctctccttcg tggatttgtg ctactcatct 240 gtcattgccc ccaatgcact ggccaactac ttctcctcat caaaggtcat cacctttgca 300 ggatgtgcca cccagttatt ctttttctct ttgctgggaa caactgaatg cttcctcctg 360 ggtgtcatgg cctacgaccg cttcatggcc atctgtagcc ccttgcgtta ccccatcacc 420 atgtgccagt ctgtctgcac ttgcctggtg ctgggcgcct actgtggagg gtgcttcaac 480 tctgttgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccgcatcaac 540 cacttcttct gtgatgtgcc ccctctgctc cagatcgcct gtggcaacac ggccatcaat 600 gaacttcttt tgtttggcat ctgtgggctc atcattgtgg gggtgacgtt tgtgatcctc 660 atctcctatg gctacatcac agtgaccatc ctgaggatgc gaacaggagc tgggagacgc 720 aaggtcttct ccacctgtgg ctcccacatg actgcagtga ccctcttttt tgggactgcc 780 tttgtcatgt atgcccagcc aggagcaatt gagtccatgg agcagggcaa ggtggtctct 840 gtcttctaca cgctggtcat cccaatgctc aatcccctca tctacagtct gcgaaacaag 900 gatgtgaagg aggccctggg gaggctgggc cagaaacaca tggccatatg a 951

<210> 1536 <211> 316 <212> PRT <213> Canis familiaris <400> 1536

Met 1 Leu Ser His Arg 5 Asn Gly Asn Leu Ser Met Val Tyr Phe Gln Asp 10 15 Phe Val Leu Glu Gly Phe Glu Ser Gly Leu Glu Thr Gln Ala Leu Leu 20 25 30 Phe Ala Val Phe Leu Ala Leu Tyr Met Val Thr Val Leu Gly Asn Phe 35 40 45

Page 1727

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Leu Met 50 Ile Ile Val Ile Thr Leu 55 Asp Ser His Leu 60 His Ser Pro Met Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser 65 70 75 80 Val Ile Ala Pro Asn Ala Leu Ala Asn Tyr Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Ala Gly Cys Ala Thr Gln Leu Phe Phe Phe Ser Leu Leu 100 105 110 Gly Thr Thr Glu Cys Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125 Met Ala Ile Cys Ser Pro Leu Arg Tyr Pro Ile Thr Met Cys Gln Ser 130 135 140 Val Cys Thr Cys Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Phe Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser Ser 165 170 175 Asn Arg Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Gln Ile 180 185 190 Ala Cys Gly Asn Thr Ala Ile Asn Glu Leu Leu Leu Phe Gly Ile Cys 195 200 205 Gly Leu Ile Ile Val Gly Val Thr Phe Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Thr Val Thr Ile Leu Arg Met Arg Thr Gly Ala Gly Arg Arg 225 230 235 240 Lys Val Phe Ser Thr Cys Gly Ser His Met Thr Ala Val Thr Leu Phe 245 250 255

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Phe Gly Thr Ala Phe Val Met Tyr Ala 265 Gln Pro Gly Ala Ile 270 Glu Ser 260 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Leu Gly Arg Leu Gly Gln Lys His Met Ala Ile 305 310 315

<210> 1537 <211> 951 <212> DNA <213> Canis familiaris <400> 1537

atgccatccc acagtagtga aaacctctct atggtctact ttcaagattt tgtgctggag 60 ggatttgagg gtggcctgga aacccaggcc ctgctctttg ctgtgttcct ggccctgtac 120 atggtgactc tgctgggcaa cttcctcatg atcatcgtta tcaccctgga tgcccgcctg 180 cactccccaa tgtacttctt cctcaagaac ctctcctttg tggacttgtg ctactcatct 240 ttcattgctc ccaaagcact ggccaacttc ttctcctcat ccaaggtcat cacctttgca 300 ggatgtgcca cccagttatt atttttctcc ttgctgggaa caactgaatg cttcctcctg 360 ggtgtcatgg cctacgaccg cttcatggcc atttgtaacc ccttgcgtta ccccatcacc 420 atgtgccagt ctgcctgcac tcgcctggtg ctgggcgcct actgtggagg ctgcttcaac 480 tctgttgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccacatcaac 540 cacttcttct gtgatgtgcc tcccttgctc aaactctcct gtggcgacac ggccatcaat 600 gaactattct tgtttggcat ctgtgggctc atcattgtgg gtgtaacaat tgtgatcctc 660 atctcctatg gctacatcac agtgaccatc ctgaggatgc gctcaggagc tgggagacgc 720 aagatcttct ccacctgtgg ctcccacatg actgcagtga ctctcttttt tgggactctc 780 tttgtcatgt atgcccagcc aggagcaatt gagtccatgg agcagggcaa ggtggtctct 840 gtcttctaca cgctggtcat cccaatgctc aatcccctca tctacagtct gcgaaacaag 900

Page 1729

069269_0225_SL.TXT gatgtgaagg aggccttgtg gaggctgggc cagaaacaca tggccttgtg a

951 <210> 1538 <211> 316 <212> PRT <213> Canis familiaris

<400> 1538 Met 1 Pro Ser His Ser 5 Ser Glu Asn Leu Ser Met Val Tyr Phe Gln Asp 10 15 Phe Val Leu Glu Gly Phe Glu Gly Gly Leu Glu Thr Gln Ala Leu Leu 20 25 30 Phe Ala Val Phe Leu Ala Leu Tyr Met Val Thr Leu Leu Gly Asn Phe 35 40 45 Leu Met Ile Ile Val Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser 65 70 75 80 Phe Ile Ala Pro Lys Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Ala Gly Cys Ala Thr Gln Leu Leu Phe Phe Ser Leu Leu 100 105 110 Gly Thr Thr Glu Cys Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125 Met Ala Ile Cys Asn Pro Leu Arg Tyr Pro Ile Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Arg Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Phe Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser Ser 165 170 175

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Asn His Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Lys Leu 180 185 190 Ser Cys Gly Asp Thr Ala Ile Asn Glu Leu Phe Leu Phe Gly Ile Cys 195 200 205 Gly Leu Ile Ile Val Gly Val Thr Ile Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Thr Val Thr Ile Leu Arg Met Arg Ser Gly Ala Gly Arg Arg 225 230 235 240 Lys Ile Phe Ser Thr Cys Gly Ser His Met Thr Ala Val Thr Leu Phe 245 250 255 Phe Gly Thr Leu Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Leu Trp Arg Leu Gly Gln Lys His Met Ala Leu 305 310 315

<210> 1539 <211> 951 <212> DNA <213> Canis <400> 1539 atgctatccc ggatttggag atggtgactg cactccccaa familiaris acagtaatga gtggtctgga tgctggggaa tgtacttctt aaacctctcc gacccaggcc catcctcatg cctcaagaac aaggtctact atgctcttca atcatcgtta ctctccttcc ttcaagattt ctgtgttcct tcaccctgga tagacttgtg tgtgctggag agccctgtac tgcccgcctg ctactcatct

120

180

240

Page 1731

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gtgatcaccc ccaatgcact ggccaacttc ttctcatcat caaagatcat cacctttgca 300 ggatgtgcca cccagttatt ctttttctcc ctgctagcca caactgaagc cttcctccta 360 ggtgtcatgg cctacgaccg cttcatggcc atctgtagcc ccttgcgcta ccccatcacc 420 atgtgccagt ctgcctgcac tcgcctggtg ctgggcgcct actgcggagg ctgcctcaac 480 tctgttgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccgcatcaac 540 cacttcttct gtgatgtgcc ccctctgctc cagatcgcct gtggcaacac gaccatcaat 600 gaacttctct tgtttggcat ctgtgggctc atcattgtgg gggtgacgtt tgtgatcctc 660 atctcctatg gctacatcat agtgaccatc ctgaggatga gctcaggagc tgggagacgc 720 aaggtcttct ccacctgtgg ctcccacatg actgcagtga ccctcttttt tgggaccgtc 780 tttgtcatgt atgcccagcc aggagcaatt gagtccatgg agcagggcaa ggtggtctct 840 gtcttctaca cactggtcat cccaatgctc aatcccctca tctacagtct gcgaaacaag 900 gatgtgaagg aggccttgtg gaggctgggc cagaaacaca tggccatgtg a 951

<210> 1540 <211> 316 <212> PRT <213> Canis familiaris <400> 1540

Met 1 Leu Ser His Ser Asn 5 Glu Asn Leu Ser Lys Val Tyr Phe Gln Asp 10 15 Phe Val Leu Glu Gly Phe Gly Gly Gly Leu Glu Thr Gln Ala Met Leu 20 25 30 Phe Thr Val Phe Leu Ala Leu Tyr Met Val Thr Val Leu Gly Asn Ile 35 40 45 Leu Met Ile Ile Val Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Leu Asp Leu Cys Tyr Ser Ser 65 70 75 80 Val Ile Thr Pro Asn Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Ile Page 1732

069269_0225_SL.TXT

85 90 95

Ile Thr Phe Ala Gly Cys Ala Thr Gln Leu Phe Phe Phe Ser Leu Leu 100 105 110 Ala Thr Thr Glu Ala Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125 Met Ala Ile Cys Ser Pro Leu Arg Tyr Pro Ile Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Arg Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Leu Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser Ser 165 170 175 Asn Arg Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Gln Ile 180 185 190 Ala Cys Gly Asn Thr Thr Ile Asn Glu Leu Leu Leu Phe Gly Ile Cys 195 200 205 Gly Leu Ile Ile Val Gly Val Thr Phe Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Ile Val Thr Ile Leu Arg Met Ser Ser Gly Ala Gly Arg Arg 225 230 235 240 Lys Val Phe Ser Thr Cys Gly Ser His Met Thr Ala Val Thr Leu Phe 245 250 255 Phe Gly Thr Val Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu

Page 1733

290 295 069269_0225_SL.TXT 300 Ala Leu Trp Arg Leu Gly Gln Lys His Met Ala Met 305 310 315

<210> 1541 <211> 951 <212> DNA <213> Canis familiaris <400> 1541

atgccatccc acagtaatgg aaacctctcc atggcctact ttcaagattt tgtgctggaa 60 ggatttggag gtggccttga gacccaggcc ctgctctttg ctgtgttcct ggccctgtat 120 atggtgactg tactgggcaa cattctcatg atcattgtta tcaccctgga tgcccgcctg 180 cactccccaa tgtacttctt cctcaagaac ctctcctttg tggacttgtg ctactcatct 240 gtgatcgccc caaatgcact ggccaacttc ttctcctcgt ccaaggtcat cacctttgca 300 ggatgtgcca cccagttttt ctttttatcc ctgctggcca caacagaagg cttcctcctg 360 ggtgtcatgg cctacgaccg cttcatggcc atctgtagcc ccttgcgcta ccccagcacc 420 atgtgccagt ctgcctgcac tcgcctggtg ctgggcgcct actgtggagg ctgcttcaac 480 tctgttgtgc agaccagctt cacattccac ctcccattct gcagctccaa ccgcatcaac 540 cacttcttct gtgatgtgcc ccctctgctc cagatcgcct gtggcaatac ggccatcaat 600 gaacttctct tgtttggcat ttgtgggttc atgattgtgg gtttggcaat tgtgatcctc 660 atctcctatg gctacatcat agcgaccatc ctgaggatgc ggtcaggagc tgggagacgc 720 aagatcttct ccacctgtgg ctcccacatg actgtagtaa ctctcttttt tgggactctc 780 tttgtcatgt atgcccagcc aggagcaatt gagtccatgg agcagggcaa ggtggtctct 840 gtcttctaca cgctggtcat cccaatgctc aatcccctca tctacagtct gcgaaacaag 900 gatgtgaagg aggctgtgca gaggctgggc cagaaacaca tgaccatgtg a 951

<210> 1542 <211> 316 <212> PRT <213> Canis familiaris <400> 1542

Page 1734

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Met 1 Pro Ser His Ser 5 Asn Gly Asn Leu Ser Met Ala Tyr Phe Gln Asp 10 15 Phe Val Leu Glu Gly Phe Gly Gly Gly Leu Glu Thr Gln Ala Leu Leu 20 25 30 Phe Ala Val Phe Leu Ala Leu Tyr Met Val Thr Val Leu Gly Asn Ile 35 40 45 Leu Met Ile Ile Val Ile Thr Leu Asp Ala Arg Leu His Ser Pro Met 50 55 60 Tyr Phe Phe Leu Lys Asn Leu Ser Phe Val Asp Leu Cys Tyr Ser Ser 65 70 75 80 Val Ile Ala Pro Asn Ala Leu Ala Asn Phe Phe Ser Ser Ser Lys Val 85 90 95 Ile Thr Phe Ala Gly Cys Ala Thr Gln Phe Phe Phe Leu Ser Leu Leu 100 105 110 Ala Thr Thr Glu Gly Phe Leu Leu Gly Val Met Ala Tyr Asp Arg Phe 115 120 125 Met Ala Ile Cys Ser Pro Leu Arg Tyr Pro Ser Thr Met Cys Gln Ser 130 135 140 Ala Cys Thr Arg Leu Val Leu Gly Ala Tyr Cys Gly Gly Cys Phe Asn 145 150 155 160 Ser Val Val Gln Thr Ser Phe Thr Phe His Leu Pro Phe Cys Ser Ser 165 170 175 Asn Arg Ile Asn His Phe Phe Cys Asp Val Pro Pro Leu Leu Gln Ile 180 185 190 Ala Cys Gly Asn Thr Ala Ile Asn Glu Leu Leu Leu Phe Gly Ile Cys 195 200 205

Page 1735

069269_0225_SL.TXT

Gly Phe Met Ile Val Gly Leu Ala Ile Val Ile Leu Ile Ser Tyr Gly 210 215 220 Tyr Ile Ile Ala Thr Ile Leu Arg Met Arg Ser Gly Ala Gly Arg Arg 225 230 235 240 Lys Ile Phe Ser Thr Cys Gly Ser His Met Thr Val Val Thr Leu Phe 245 250 255 Phe Gly Thr Leu Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 260 265 270 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 275 280 285 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Ala Val Gln Arg Leu Gly Gln Lys His Met Thr Met

305 310 315 <210> 1543 <211> 861 <212> DNA <213> Canis familiaris <400> 1543

cactttcaag attttgtact agagggattt aggggtggtc tggagaccca agccatgctc 60 ttcactgtgt tcttggcctt gtacatggtg actatactgg gcaacttcct catgatcatc 120 tctagcaccc tggatgcctg cctacacttc ccaatgtatg tcttcctcaa gaacccctcc 180 ttcgtggact tgtgctactc atctgtcatt gcccccaatg caccggccaa ctacttctcc 240 tcatccaagg tcatcacctt tacagaatgt gccacccagt ttttcttttt atccctggtg 300 gctaccactg aatgcttcct cctgggtgtt atgtcctacg accacttcat gaccatttgt 360 agacccttga gctaccctag caccatgtgc cagtctggct gcactcgcct ggtgctgtgc 420 acctactgtg gaggctgctt caactcttca actctggtgc agagaagctt cacattcaac 480 ctctcattct gcagctccaa ctgcatcaac cacgtcctct gtgatgtgcc ccctctgttc 540

Page 1736

069269_0225_SL.TXT catatcgcct gtggcaagac ggccatcaat gaacttctct tgtttggcat ctgtgggctc atgattgtgt gtgtgacata tatggtcctc atctcctatg gttacataat agtgtccatc ctgaggatgg gctcaggagc gtttgggacc gtctttgtaa tatataccca gccaggagca actgagtcca tggagcaggg caaggtggtc tctgtcttct acacgctggt catcccagag ctcaatcccc tcatctacag tctgcaaaac aaggatgtga aggaggctgt gtggaggctg ggccagaaac acatggccac g

600

660

720

780

840

861 <210> 1544 <211> 287 <212> PRT <213> Canis familiaris

<400> 1544 His 1 Phe Gln Asp Phe Val 5 Leu Glu Gly Phe 10 Arg Gly Gly Leu Glu Thr 15 Gln Ala Met Leu Phe Thr Val Phe Leu Ala Leu Tyr Met Val Thr Ile 20 25 30 Leu Gly Asn Phe Leu Met Ile Ile Ser Ser Thr Leu Asp Ala Cys Leu 35 40 45 His Phe Pro Met Tyr Val Phe Leu Lys Asn Pro Ser Phe Val Asp Leu 50 55 60 Cys Tyr Ser Ser Val Ile Ala Pro Asn Ala Pro Ala Asn Tyr Phe Ser 65 70 75 80 Ser Ser Lys Val Ile Thr Phe Thr Glu Cys Ala Thr Gln Phe Phe Phe 85 90 95 Leu Ser Leu Val Ala Thr Thr Glu Cys Phe Leu Leu Gly Val Met Ser 100 105 110 Tyr Asp His Phe Met Thr Ile Cys Arg Pro Leu Ser Tyr Pro Ser Thr 115 120 125 Met Cys Gln Ser Gly Cys Thr Arg Leu Val Leu Cys Thr Tyr Cys Gly

Page 1737

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130 135 140

Gly 145 Cys Phe Asn Ser Ser Thr Leu Val Gln Arg Ser Phe Thr Phe Asn 150 155 160 Leu Ser Phe Cys Ser Ser Asn Cys Ile Asn His Val Leu Cys Asp Val 165 170 175 Pro Pro Leu Phe His Ile Ala Cys Gly Lys Thr Ala Ile Asn Glu Leu 180 185 190 Leu Leu Phe Gly Ile Cys Gly Leu Met Ile Val Cys Val Thr Tyr Met 195 200 205 Val Leu Ile Ser Tyr Gly Tyr Ile Ile Val Ser Ile Leu Arg Met Gly 210 215 220 Ser Gly Ala Phe Gly Thr Val Phe Val Ile Tyr Thr Gln Pro Gly Ala 225 230 235 240 Thr Glu Ser Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu 245 250 255 Val Ile Pro Glu Leu Asn Pro Leu Ile Tyr Ser Leu Gln Asn Lys Asp 260 265 270 Val Lys Glu Ala Val Trp Arg Leu Gly Gln Lys His Met Ala Thr 275 280 285

<210> 1545 <211> 567 <212> DNA <213> Canis familiaris <400> 1545 atggctatct gtcaccccct gcattacatg gttatcatga atccctggct ctgtggactg ctggttctag tgtcctgaat tccttattac agagcttaat ggtgttgtgg gtgtccttct gtacaggcac agaaatcctt catttttttt taactcaatc aagtaatcag gaatgcctgt tctgacactt ttcttaatga catggtgata tattttatga ctgtgctgct ggcaggtggt Page 1738

120

180

240

069269_0225_SL.TXT cctttcactg ggttccttta ctcttgtttc ccccgtacat agaatctcat catcttagag 300 caagtataaa gcattttcta cctgtgcatc tcacctcttg gttgtctcct tattttactc 360 tacaagcctt gaagtgtact ttagctctgc tgctccccag agctcccaca caagtgcagt 420 ggcctcggtg atatacacat agtcataccc atgctgaacc ccttcatcta tagtctgaag 480 aacagagaca taaagagggc tctgaaaaga atctttgggg ttccagtgat gcagtggcca 540 gtcatcctgg ggctgaagat gtgccca 567 <210> 1546 <211> 70 <212> PRT <213> Canis familiaris <400> 1546

Trp 1 Ala His Leu Gln Pro Gln Asp Asp Trp Pro Leu His His Trp Asn 5 10 15 Pro Lys Asp Ser Phe Gln Ser Pro Leu Tyr Val Ser Val Leu Gln Thr 20 25 30 Ile Asp Glu Gly Val Gln His Gly Tyr Asp Tyr Val Tyr Ile Thr Glu 35 40 45 Ala Thr Ala Leu Val Trp Glu Leu Trp Gly Ala Ala Glu Leu Lys Tyr 50 55 60 Thr Ser Arg Leu Val Glu

65 70 <210> 1547 <211> 939 <212> DNA <213> Canis familiaris <400> 1547 atgaggaatc agtcaacaaa gattgagttc tttctcctgg ggctgaccga tgacccacaa 60 ctgcaaattg tgatttttac gtttctcttc atcaactatg tgctgagcat gactggaaac 120 ttaaccatca tccttctcac cctgctacat cccagcctca agactcccat gtattttttc 180

Page 1739

069269_0225_SL.TXT

ctccgaaatt tctcctttat ggaagcttca atgacaacag tctgtattcc cagattcctg 240 ataagcctca taactaaaaa caaagtcatt tcctacaatt gttgtgcatc tcagttattc 300 tttttcctcc aattagaaat tgcagaattt tacctgctgg ctgccatgtc ctttgaccgt 360 tatgtagcaa tctgcaaacc cctgcattac ctgatcatca tgaacaacaa aatgtgctac 420 caactcctgt tcagctcatg ggccgtgggc tttctgctgt cgttttcacc attagctgtg 480 ggcctcacac tggatttctg tgtttccgga ataattgatc atttcatgtg tgacatttcc 540 cctgtgctgc agctttcctg cactgacact cgtttcttgg aattgctttc gtttgcctta 600 gctattgtaa cacttctggt gaccttacta ttagtgattc tttcttacac atacattatc 660 aagaccattc tcaagatccc ctctgctcag aaaagaacca aggctttttc tacttgttct 720 tctcatatga ttgtggtctc ccttacgtat ggtagctgca tctttaatta cataaagcca 780 acagcgaagg aaagggtgac tttgtccaaa ggtgtaagtg ttatttatac ctcggttgcc 840 cctttattaa accctttcat ttacagtctc agaaaccagc aagtcaaaca agccttcaag 900 gacacactcc aaaagatttt ctctctttcc agaaaataa 939

<210> 1548 <211> 312 <212> PRT <213> Canis familiaris <400> 1548

Met Arg Asn Gln Ser Thr Lys Ile Glu Phe Phe Leu Leu Gly Leu Thr 1 5 10 15 Asp Asp Pro Gln Leu Gln Ile Val Ile Phe Thr Phe Leu Phe Ile Asn 20 25 30 Tyr Val Leu Ser Met Thr Gly Asn Leu Thr Ile Ile Leu Leu Thr Leu 35 40 45 Leu His Pro Ser Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Met Glu Ala Ser Met Thr Thr Val Cys Ile Pro Arg Phe Leu 65 70 75 80

Page 1740

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Ile Ser Leu Ile Thr 85 Lys Asn Lys Val Ile Ser Tyr Asn Cys Cys Ala 90 95 Ser Gln Leu Phe Phe Phe Leu Gln Leu Glu Ile Ala Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Ile Ile Met Asn Asn Lys Met Cys Tyr Gln Leu Leu Phe 130 135 140 Ser Ser Trp Ala Val Gly Phe Leu Leu Ser Phe Ser Pro Leu Ala Val 145 150 155 160 Gly Leu Thr Leu Asp Phe Cys Val Ser Gly Ile Ile Asp His Phe Met 165 170 175 Cys Asp Ile Ser Pro Val Leu Gln Leu Ser Cys Thr Asp Thr Arg Phe 180 185 190 Leu Glu Leu Leu Ser Phe Ala Leu Ala Ile Val Thr Leu Leu Val Thr 195 200 205 Leu Leu Leu Val Ile Leu Ser Tyr Thr Tyr Ile Ile Lys Thr Ile Leu 210 215 220 Lys Ile Pro Ser Ala Gln Lys Arg Thr Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Val Ser Leu Thr Tyr Gly Ser Cys Ile Phe Asn 245 250 255 Tyr Ile Lys Pro Thr Ala Lys Glu Arg Val Thr Leu Ser Lys Gly Val 260 265 270 Ser Val Ile Tyr Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285

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069269_0225_SL.TXT

Ser Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asp Thr Leu Gln 290 295 300

Lys Ile Phe Ser Leu Ser Arg Lys

305 310 <210> 1549 <211> 936 <212> DNA <213> Canis familiaris <400> 1549

atggaaaacc atacaactgt gacagtattt atcttagcag gattgacgga ggacccaaaa 60 ctgaagattg tgctatttgt cttcctgctc ctcacctatt tgctaagcat ctcaggcaac 120 ttagtcatta ttaccctcac tttgctggac tcccatctca agacccctat gtatttcttt 180 cttcgaaatt tttctttctt agaaatttct tatacgacag tctgcatccc caaattgctt 240 gtaagcatgg caaccggtga caaaaccatt tcctataact gttgtgcaac tcagttattt 300 tttgccttcc ttcttggagc atctgaattt tacctcctgg ctgtcatgtc ctatgatcgt 360 tatgtcgcca tctgcaagcc cctgcattac acaaccatta tgagcagcaa aatctgtatc 420 cagctagtcc ttagctcttg gatcactggt ttcctcatca tctttccagg actcatttta 480 ggcttaagcc tggacttctg tgattccaat gtcattgatc atttctactg tgacacggct 540 cccctcctgc agatctcctg cacagacaca cacgtgttgg aaatgatgag tttcatctta 600 gctttggtga ctctgctggt cactttggcc ttagtgattc tatcgtacac atatatcgcc 660 ctgacaattt taaaaattcc ttctgccaac cagagaaaaa aggctttctc cacctgttct 720 tctcacatga ttgtcatctc cctctcatac ggcagctgca tctttatgta cattaaaccc 780 tcggtcaaac agaggatatc cttgatgaag ggggtggcag ttctcaatac ttctgttgct 840 ccacttttga atccctttat ctatactcta aggaaccagc aggtgaagca agcatttaag 900 aacttgctac aaagagttct gtctttattc aaatag 936

<210> 1550 <211> 311 <212> PRT <213> Canis familiaris

Page 1742

069269_0225_SL.TXT

<400> 1550 Thr Thr Val Thr Val Phe Ile Leu Ala Gly Leu Thr 15 Met 1 Glu Asn His 5 10 Glu Asp Pro Lys Leu Lys Ile Val Leu Phe Val Phe Leu Leu Leu Thr 20 25 30 Tyr Leu Leu Ser Ile Ser Gly Asn Leu Val Ile Ile Thr Leu Thr Leu 35 40 45 Leu Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Tyr Thr Thr Val Cys Ile Pro Lys Leu Leu 65 70 75 80 Val Ser Met Ala Thr Gly Asp Lys Thr Ile Ser Tyr Asn Cys Cys Ala 85 90 95 Thr Gln Leu Phe Phe Ala Phe Leu Leu Gly Ala Ser Glu Phe Tyr Leu 100 105 110 Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Ser Ser Lys Ile Cys Ile Gln Leu Val Leu 130 135 140 Ser Ser Trp Ile Thr Gly Phe Leu Ile Ile Phe Pro Gly Leu Ile Leu 145 150 155 160 Gly Leu Ser Leu Asp Phe Cys Asp Ser Asn Val Ile Asp His Phe Tyr 165 170 175 Cys Asp Thr Ala Pro Leu Leu Gln Ile Ser Cys Thr Asp Thr His Val 180 185 190 Leu Glu Met Met Ser Phe Ile Leu Ala Leu Val Thr Leu Leu Val Thr 195 200 205

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Leu Ala Leu Val Ile Leu Ser Tyr Thr Tyr Ile Ala Leu Thr Ile Leu 210 215 220 Lys Ile Pro Ser Ala Asn Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Ile Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Lys Pro Ser Val Lys Gln Arg Ile Ser Leu Met Lys Gly Val 260 265 270 Ala Val Leu Asn Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asn Leu Leu Gln 290 295 300 Arg Val Leu Ser Leu Phe Lys

305 310 <210> 1551 <211> 948 <212> DNA <213> Canis familiaris <400> 1551

atgatgggaa accagacatc ggtgatagaa ttcattcttc ttggactgac gaatgacgct 60 gagcttcaag ctgtgctttt cccttttctg ctgctaactt acgtcttgag catcatggga 120 aacttgacca tcatcattct gaccctgttg gattatcgcc tgcagactcc tatgtatttc 180 tttctccgga atttttctgt tttggaaata tcttttactt ctgtctttgt tcccaaaatg 240 ctagtcaaca ttgcaactgg agacaagact atctccttcg ctggttgttt cactcagtat 300 ttttttgcca tccttctggg ggcaactgaa ttttatcttt tagctgccat gtcctacgat 360 cgctatgttg ccatttgtaa acccctgcac tatacaactg taatgagcag gaaactctgc 420 attcagcttg ttctgtgttc ctggttctct ggttttttgg ttgtcgttgt gccacatgca 480

Page 1744

069269_0225_SL.TXT

atgactctcc agctgccttt ctgtgcctcc aatgtcatca accattattg ctgtgactat 540 accgttctgc tgcatctgtc ctgttcagac acacagttca tagaagtgat ggagtttatc 600 tttgcagcag ttaccctcat cttgactttg gtgccggtga ctctttccta cacgtacatc 660 atcaggacaa ttctgagaat cccctctgtt caacaaagaa aaaaagcctt ttctacatgc 720 tcctctcata tgattgtggt ctcactttct tatggaagtt gtatctttat gtacataaat 780 ccttctgtta aggatgcaga aacgtttaat aagagagtgg ctgttttaaa tacctcagtt 840 gcccctctgt tgaacccttt catctatacc ctaaggaaca agcaggtgaa aatagccttc 900 aaagacatgg tcagcaagat aacgatgttt tcaggaaaac gaaagtga 948 <210> 1552 <211> 315 <212> PRT <213> Canis familiaris <400> 1552 Met Met Gly Asn Gln Thr Ser Val Ile Glu Phe Ile Leu Leu Gly Leu 1 5 10 15 Thr Asn Asp Ala Glu Leu Gln Ala Val Leu Phe Pro Phe Leu Leu Leu 20 25 30 Thr Tyr Val Leu Ser Ile Met Gly Asn Leu Thr Ile Ile Ile Leu Thr 35 40 45 Leu Leu Asp Tyr Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn 50 55 60 Phe Ser Val Leu Glu Ile Ser Phe Thr Ser Val Phe Val Pro Lys Met 65 70 75 80 Leu Val Asn Ile Ala Thr Gly Asp Lys Thr Ile Ser Phe Ala Gly Cys 85 90 95 Phe Thr Gln Tyr Phe Phe Ala Ile Leu Leu Gly Ala Thr Glu Phe Tyr 100 105 110 Leu Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro

Page 1745

115 069269_0225_SL.TXT 120 125 Leu His Tyr Thr Thr Val Met Ser Arg Lys Leu Cys Ile Gln Leu Val 130 135 140 Leu Cys Ser Trp Phe Ser Gly Phe Leu Val Val Val Val Pro His Ala 145 150 155 160 Met Thr Leu Gln Leu Pro Phe Cys Ala Ser Asn Val Ile Asn His Tyr 165 170 175 Cys Cys Asp Tyr Thr Val Leu Leu His Leu Ser Cys Ser Asp Thr Gln 180 185 190 Phe Ile Glu Val Met Glu Phe Ile Phe Ala Ala Val Thr Leu Ile Leu 195 200 205 Thr Leu Val Pro Val Thr Leu Ser Tyr Thr Tyr Ile Ile Arg Thr Ile 210 215 220 Leu Arg Ile Pro Ser Val Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Met Ile Val Val Ser Leu Ser Tyr Gly Ser Cys Ile Phe 245 250 255 Met Tyr Ile Asn Pro Ser Val Lys Asp Ala Glu Thr Phe Asn Lys Arg 260 265 270 Val Ala Val Leu Asn Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Gln Val Lys Ile Ala Phe Lys Asp Met Val 290 295 300 Ser Lys Ile Thr Met Phe Ser Gly Lys Arg Lys 305 310 315

<210> 1553

Page 1746

069269_0225_SL.TXT <211> 948 <212> DNA <213> Canis familiaris <400> 1553

atgatttgtg aaaatcacac cagagtcact gaatttgttc ttctcggttt tacaaataac 60 cctgagatgc aagtttccct ctttattttg ttcctcatca tctatacagt cactttgttg 120 ggcaatttcc ttattatcac agttaccagt gtggatcctg ctcttcaaac acccatgtac 180 ttctttctcc gaaacctatc acttcttgaa gtctgtttta ccttggtcat ggtgccgaag 240 atgctggtgg atctagtgtc cctaaggaag atcatctctt ttgtgggctg tggtatccag 300 atgtactttt tctttttctt cggcagctcc gaatgttttc tcctgtctat gatggcatat 360 gatcgctttg tggccattgg taaccctctc cgttattcag tcataatgaa taggtcccta 420 tgtttatgga tggctgtcgg ctcttggatg tctggggttc ctgtctctat gctacaaaca 480 gcttggttga tggcccttcc tttctgtgga ccaaatacca tagaccactt tttttgtgat 540 ggtcccccag tgctgaaact agtcactcaa gatacaacca tgtatgaaat gcaagcactt 600 gcttccacac tactgtttat catgtttccc ttttccctca ttttggtctc ctacacccgc 660 attatcataa ccatcctgaa gatgccctct gctaccggtc gtcagaaggc attctccact 720 tgttcatcac acctcattgt ggtatccctt ttctatggaa cagccagctt gacctacctg 780 cgacccaaat ccaaccagtc cccagagagc aagaagctag tgtcattgtc ctacactgtc 840 atcactccta tgttaaaccc catcatctac agcctaagga acaatgaagt gaagggggca 900 gtcaagagga cagttacccg aaaagtcttg aagttagatg cgttttga 948

<210> 1554 <211> 315 <212> PRT <213> Canis familiaris <400> 1554

Met 1 Ile Cys Glu Asn His Thr Arg Val Thr Glu Phe Val Leu Leu Gly 5 10 15 Phe Thr Asn Asn Pro Glu Met Gln Val Ser Leu Phe Ile Leu Phe Leu 20 25 30

Page 1747

Ile Ile Tyr 35 Thr Val Thr Leu 069269_0225_SL.TXT Leu Gly Asn Phe Leu Ile 40 45 Ile Thr Val Thr Ser Val Asp Pro Ala Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Leu Leu Glu Val Cys Phe Thr Leu Val Met Val Pro Lys 65 70 75 80 Met Leu Val Asp Leu Val Ser Leu Arg Lys Ile Ile Ser Phe Val Gly 85 90 95 Cys Gly Ile Gln Met Tyr Phe Phe Phe Phe Phe Gly Ser Ser Glu Cys 100 105 110 Phe Leu Leu Ser Met Met Ala Tyr Asp Arg Phe Val Ala Ile Gly Asn 115 120 125 Pro Leu Arg Tyr Ser Val Ile Met Asn Arg Ser Leu Cys Leu Trp Met 130 135 140 Ala Val Gly Ser Trp Met Ser Gly Val Pro Val Ser Met Leu Gln Thr 145 150 155 160 Ala Trp Leu Met Ala Leu Pro Phe Cys Gly Pro Asn Thr Ile Asp His 165 170 175 Phe Phe Cys Asp Gly Pro Pro Val Leu Lys Leu Val Thr Gln Asp Thr 180 185 190 Thr Met Tyr Glu Met Gln Ala Leu Ala Ser Thr Leu Leu Phe Ile Met 195 200 205 Phe Pro Phe Ser Leu Ile Leu Val Ser Tyr Thr Arg Ile Ile Ile Thr 210 215 220 Ile Leu Lys Met Pro Ser Ala Thr Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240

Page 1748

Cys Ser Ser His Leu 245 Ile Val 069269_0225_SL.TXT Val Ser Leu Phe Tyr Gly 250 Thr Ala 255 Ser Leu Thr Tyr Leu Arg Pro Lys Ser Asn Gln Ser Pro Glu Ser Lys Lys 260 265 270 Leu Val Ser Leu Ser Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Asn Glu Val Lys Gly Ala Val Lys Arg Thr 290 295 300 Val Thr Arg Lys Val Leu Lys Leu Asp Ala Phe

305 310 315 <210> 1555 <211> 948 <212> DNA <213> Canis familiaris <400> 1555

atgaagagcg agctgagccg gaattcctca ggagtgactg agttcattct gctgggcttc 60 agaacagctc cagacataca gatcctctta ttcctattct tcttgctggt ctacgtggtc 120 atcgtggtgg gaaatagcag catgataatt gtcatcagga tggactcgag gcttcacaca 180 cctatgtatt tcttccttag aaacttgtcc tatttagatc tctgctactc cacagtcatt 240 gctcccaaag ctctggctac tttcttgtcc aaggacaaga aaatttccta caatggctgc 300 gcagcacagt tctttttctt tgctctctgt gttgggactg agggctttct tctggccgtg 360 atggcctatg atcgtttctc agccatttgc tcgccattcc tctatcctgt ccgtatgtct 420 caacaggttt gtgttcactt agtaattggc tcctacatct gtggaggcct caactccatg 480 gtccaaacag gattcacctt cagcttgcgt ttctgtggag aaaaccgcct ggaccacttc 540 ttctgtgacg tcccagccct gatcaagatc tcatgtgttg acacgtctgt gaacgagatg 600 gtgctgttca tcctctcctc cctcatcatt gtcaccacca cgactgtcat cctggtttcc 660 tatgcttaca tactctccac tgtcctgaag atcccctcca cccacggcag gggtaagacc 720 ttctccacct gtagctctca catcactgtg gtgagtttgt tctatgggac cgtgttcttc 780

Page 1749

069269_0225_SL.TXT atgtacgccc agcccggggc catctcctcc ccagagaaaa gcaagattat agctgtgttc tacactctta tcatccctat gttgaatcca ctgatttata gtctaaggaa taaggaggtg aaaaatgctg taaaaagggt attgttgaga agattatctt tccattga

840

900

948 <210> 1556 <211> 315 <212> PRT <213> Canis familiaris

<400> 1556 Met 1 Lys Ser Glu Leu Ser 5 Arg Asn Ser Ser Gly Val Thr Glu Phe Ile 10 15 Leu Leu Gly Phe Arg Thr Ala Pro Asp Ile Gln Ile Leu Leu Phe Leu 20 25 30 Phe Phe Leu Leu Val Tyr Val Val Ile Val Val Gly Asn Ser Ser Met 35 40 45 Ile Ile Val Ile Arg Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Arg Asn Leu Ser Tyr Leu Asp Leu Cys Tyr Ser Thr Val Ile 65 70 75 80 Ala Pro Lys Ala Leu Ala Thr Phe Leu Ser Lys Asp Lys Lys Ile Ser 85 90 95 Tyr Asn Gly Cys Ala Ala Gln Phe Phe Phe Phe Ala Leu Cys Val Gly 100 105 110 Thr Glu Gly Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Ser Ala 115 120 125 Ile Cys Ser Pro Phe Leu Tyr Pro Val Arg Met Ser Gln Gln Val Cys 130 135 140 Val His Leu Val Ile Gly Ser Tyr Ile Cys Gly Gly Leu Asn Ser Met 145 150 155 160

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Val Gln Thr Gly Phe Thr Phe Ser Leu Arg Phe Cys Gly Glu Asn Arg 165 170 175 Leu Asp His Phe Phe Cys Asp Val Pro Ala Leu Ile Lys Ile Ser Cys 180 185 190 Val Asp Thr Ser Val Asn Glu Met Val Leu Phe Ile Leu Ser Ser Leu 195 200 205 Ile Ile Val Thr Thr Thr Thr Val Ile Leu Val Ser Tyr Ala Tyr Ile 210 215 220 Leu Ser Thr Val Leu Lys Ile Pro Ser Thr His Gly Arg Gly Lys Thr 225 230 235 240 Phe Ser Thr Cys Ser Ser His Ile Thr Val Val Ser Leu Phe Tyr Gly 245 250 255 Thr Val Phe Phe Met Tyr Ala Gln Pro Gly Ala Ile Ser Ser Pro Glu 260 265 270 Lys Ser Lys Ile Ile Ala Val Phe Tyr Thr Leu Ile Ile Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Val 290 295 300 Lys Arg Val Leu Leu Arg Arg Leu Ser Phe His 305 310 315

<210> 1557 <211> 963 <212> DNA <213> Canis familiaris <400> 1557 atgggtgaca ggggaaccag caatcgctca gaagtgactg acttcattct tgtaggcttc agggtccgcc ccgagctcta cattctcctc ttcctgctct tcctgcttgt gtatgccatg

120 atcctgctgg ggaatgttgg gatggtggcc gttatcctga ctgatcccag gctgaacaca Page 1751

180

069269_0225_SL.TXT

ccgatgtact tcctcctggg caacctctcc ttcattgacc tcttctactc ctctgtaatt 240 gcccccaagg ctatgatcaa cttctggtct gagagcaagt ccatctcctt tgcaggctgt 300 gcgacccagc tctttctctt tgccctcttc attgtggctg aggggtttct cctggctgcc 360 atggcttatg accgcttcat tgccatctgc aacccactcc tctactccgt ccagatgtca 420 acgcgtctct gcatccagtt ggtggctggt tcctattttt gtggctgcat cagctcggtt 480 cttcagacga gtatgacatt tagtatgtcc ttttgtgctt cccgggccat tgaccacttt 540 tactgtgatg accgtccact tcaaaggatt tcttgctctg atctctactt tcataagata 600 gtttcctttc tcttatgcag cattattatt ttgcccacca tcattgtcat tctcgtgtcc 660 tatatgtata ttgtgtccac agttctaaag ataagatcca ctgagggacg taagaaagcc 720 ttctccactt gcagctctca cctaggggtc gtgagcgtcc tgtacggtgc catcattttt 780 atgtatttca tccctgacag attccctgag ctgagtaaag tggcttcctt atgttatacg 840 ttagtcactc ccatgttgaa tcctttgatt tactccctga gaaacaaaga tgtcaaagag 900 gctctgagaa agatcctggg gaaaaaaata tttttattta attctatctt aacagtgata 960

taa 963 <210> 1558 <211> 320 <212> PRT <213> Canis familiaris <400> 1558

Met Gly Asp Arg Gly Thr Ser Asn Arg Ser Glu Val Thr Asp Phe Ile 1 5 10 15 Leu Val Gly Phe Arg Val Arg Pro Glu Leu Tyr Ile Leu Leu Phe Leu 20 25 30 Leu Phe Leu Leu Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 35 40 45 Val Ala Val Ile Leu Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60

Page 1752

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Leu 65 Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 70 75 80 Ala Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Ser Lys Ser Ile Ser 85 90 95 Phe Ala Gly Cys Ala Thr Gln Leu Phe Leu Phe Ala Leu Phe Ile Val 100 105 110 Ala Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Ser Thr Arg Leu Cys 130 135 140 Ile Gln Leu Val Ala Gly Ser Tyr Phe Cys Gly Cys Ile Ser Ser Val 145 150 155 160 Leu Gln Thr Ser Met Thr Phe Ser Met Ser Phe Cys Ala Ser Arg Ala 165 170 175 Ile Asp His Phe Tyr Cys Asp Asp Arg Pro Leu Gln Arg Ile Ser Cys 180 185 190 Ser Asp Leu Tyr Phe His Lys Ile Val Ser Phe Leu Leu Cys Ser Ile 195 200 205 Ile Ile Leu Pro Thr Ile Ile Val Ile Leu Val Ser Tyr Met Tyr Ile 210 215 220 Val Ser Thr Val Leu Lys Ile Arg Ser Thr Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 245 250 255 Ala Ile Ile Phe Met Tyr Phe Ile Pro Asp Arg Phe Pro Glu Leu Ser 260 265 270

Page 1753

Lys Val Ala 275 Ser Leu Cys Tyr 069269_0225_SL.TXT Thr Leu Val Thr Pro Met 280 285 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys 290 295 300 Ile Leu Gly Lys Lys Ile Phe Leu Phe Asn Ser Ile Leu Thr Val Ile 305 310 315 320

<210> 1559 <211> 897 <212> DNA <213> Canis familiaris <400> 1559

atgagaaatc acacaaaggt aacagagttt attcttctcg ggttgaccga tgacccaaag 60 tggcaggttg tacttttcat atttctcctg gtcacctaca tgtgcagtgt gactgggaac 120 ctggtcatta tcttcctcac cctttacgat ccccacctga agactccaat gtattcttcc 180 cttcgaattc ccagattcct tgtcactgtt gtgacgggag acagaaccat ttcctacaat 240 gactgtctgg ctcaggtatt cttcgtcatc ttattggggg tgacagagtt ttacctcctg 300 accgccatgt cctatgaccg ctacatggcc atctgcaaac ctctgcatta catgaccatc 360 atgagcagca gagtctgcat cctccttgtc tttagctcat ggcttgcagg attcctggtc 420 atctttccac ctgtaattct ggtgctgaag ttggatttct gtgcctccaa tataatcgat 480 cattttgtct gtgactcttc accaattcta cagctttctt gcacaaacac tcactttcta 540 gaactcatgg catttgtttt agcggtggta acgcttatgg tcaccttaac cctagttatg 600 ctctcctaca cacacatcat ccgcacaatt ctgagaattc cttccacgag tcaaaggaaa 660 aaagcctttt ccacgtgttc ctcccacatg atagtggtct ccctctctta tggcagctgc 720 atcttcatgt acatcaagcc ttctgcaaag gaaagggtga gtttaaacaa aggcgtagct 780 gtgatcatta cctcagtgac tcctcttctc aatcctttca tatatacctt aagaaaccag 840 caggtgaaac aagccttcaa aaacatggtc cacagaatgg tcttttcttc atataaa 897

<210> 1560 <211> 299 <212> PRT

Page 1754

069269_0225_SL.TXT <213> Canis familiaris <400> 1560

Met Arg Asn His Thr Lys Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asp Asp Pro Lys Trp Gln Val Val Leu Phe Ile Phe Leu Leu Val Thr 20 25 30 Tyr Met Cys Ser Val Thr Gly Asn Leu Val Ile Ile Phe Leu Thr Leu 35 40 45 Tyr Asp Pro His Leu Lys Thr Pro Met Tyr Ser Ser Leu Arg Ile Pro 50 55 60 Arg Phe Leu Val Thr Val Val Thr Gly Asp Arg Thr Ile Ser Tyr Asn 65 70 75 80 Asp Cys Leu Ala Gln Val Phe Phe Val Ile Leu Leu Gly Val Thr Glu 85 90 95 Phe Tyr Leu Leu Thr Ala Met Ser Tyr Asp Arg Tyr Met Ala Ile Cys 100 105 110 Lys Pro Leu His Tyr Met Thr Ile Met Ser Ser Arg Val Cys Ile Leu 115 120 125 Leu Val Phe Ser Ser Trp Leu Ala Gly Phe Leu Val Ile Phe Pro Pro 130 135 140 Val Ile Leu Val Leu Lys Leu Asp Phe Cys Ala Ser Asn Ile Ile Asp 145 150 155 160 His Phe Val Cys Asp Ser Ser Pro Ile Leu Gln Leu Ser Cys Thr Asn 165 170 175 Thr His Phe Leu Glu Leu Met Ala Phe Val Leu Ala Val Val Thr Leu 180 185 190 Met Val Thr Leu Thr Leu Val Met Leu Ser Tyr Thr His Ile Ile Arg

Page 1755

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195 200 205 Thr Ile Leu Arg Ile Pro Ser Thr Ser Gln Arg Lys Lys Ala Phe Ser 210 215 220 Thr Cys Ser Ser His Met Ile Val Val Ser Leu Ser Tyr Gly Ser Cys 225 230 235 240 Ile Phe Met Tyr Ile Lys Pro Ser Ala Lys Glu Arg Val Ser Leu Asn 245 250 255 Lys Gly Val Ala Val Ile Ile Thr Ser Val Thr Pro Leu Leu Asn Pro 260 265 270 Phe Ile Tyr Thr Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asn 275 280 285 Met Val His Arg Met Val Phe Ser Ser Tyr Lys 290 295 <210> 1561 <211> 939 <212> DNA <213> Canis familiaris <400> 1561 atgagaaatc acacaaaggt aacagagttt attcttctcg ggttgaccga tgacccaaag 60 tggcaggttg tacttttcat atttctcctg gtcacctaca tgtgcagtgt gactgggaac 120 ctggtcatta tcttcctcac ccttacggat ccccacctga agactccaat gtatttcttc 180 cttcgaaact tctcattcct agaaatgtca ttcacgtctg ccacaattcc cagattcctt 240 gtcactgttg tgacgggaga cagaaccatt tcctacaatg actgtctggc tcaggtattt 300 ttcgtcatct tattgggggt gacagagttt tacctcctga ccgccatgtc ctatgaccgc 360 tacgtggcca tctgcaaacc tctgcattac atgaccatca tgagcaccag agtctgcatc 420 ctccttgtct ttagctcatg gcttgcagga ttcctggtca tctttccacc tgtaattctg 480 atgctgaagt tggatttctg tgcctccaat ataatcgatc attttgtctg tgactcttca 540 ccaattatac agctttcttg cacaaacact cactttctag aactcatggc atttgtttta 600

Page 1756

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gcggtggtaa cgcttatggt caccttaacc ctagttatgc tctcctacac acacatcatc 660 cgcacaattc tgagaattcc ttccacgagt caaaggaaaa aagccttttc cacgtgttcc 720 tcccacatga tagtagtctc cctctcttat ggcagctgca tcttcatgta catcaagcct 780 tctgcaaagg aaagggtgag tttaaacaaa ggcgtagctg tgatcattac ctcagtgact 840 cccctcctca atcctttcat atatacctta agaaaccagc aggtgaagca agccttcaag 900 aacatggtcc acagaatggt cttttcttca tataaatga 939 <210> 1562 <211> 312 <212> PRT <213> Canis familiaris <400> 1562 Met Arg Asn His Thr Lys Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asp Asp Pro Lys Trp Gln Val Val Leu Phe Ile Phe Leu Leu Val Thr 20 25 30 Tyr Met Cys Ser Val Thr Gly Asn Leu Val Ile Ile Phe Leu Thr Leu 35 40 45 Thr Asp Pro His Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Leu Glu Met Ser Phe Thr Ser Ala Thr Ile Pro Arg Phe Leu 65 70 75 80 Val Thr Val Val Thr Gly Asp Arg Thr Ile Ser Tyr Asn Asp Cys Leu 85 90 95 Ala Gln Val Phe Phe Val Ile Leu Leu Gly Val Thr Glu Phe Tyr Leu 100 105 110 Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu

115 120 125

Page 1757

His Tyr 130 Met Thr Ile Met Ser 135 069269_0225_SL.TXT Thr Arg Val Cys Ile Leu 140 Leu Val Phe Ser Ser Trp Leu Ala Gly Phe Leu Val Ile Phe Pro Pro Val Ile Leu 145 150 155 160 Met Leu Lys Leu Asp Phe Cys Ala Ser Asn Ile Ile Asp His Phe Val 165 170 175 Cys Asp Ser Ser Pro Ile Ile Gln Leu Ser Cys Thr Asn Thr His Phe 180 185 190 Leu Glu Leu Met Ala Phe Val Leu Ala Val Val Thr Leu Met Val Thr 195 200 205 Leu Thr Leu Val Met Leu Ser Tyr Thr His Ile Ile Arg Thr Ile Leu 210 215 220 Arg Ile Pro Ser Thr Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Val Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Lys Pro Ser Ala Lys Glu Arg Val Ser Leu Asn Lys Gly Val 260 265 270 Ala Val Ile Ile Thr Ser Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asn Met Val His 290 295 300 Arg Met Val Phe Ser Ser Tyr Lys 305 310

<210> 1563 <211> 942 <212> DNA <213> Canis familiaris

Page 1758

069269_0225_SL.TXT <400> 1563 atgaacgaca agggagcggg caactactca gatgtaactg acttcactct tgtaggcttc 60 agggtccgtc cagagctcca cattctcctc ttcctcctat tcctgctggt ctatagcatg 120 gtccttttgg ggaactttag tatgattggc atcattgtga ctgactccca gctgaacaca 180 ccaatgtatt tctttctagg caatctctcc ttcattgacc tctcctactc cactattatt 240 gccccgaaag ccatggtcaa cttcctgtct gagaaaaata ctgtctcctt tttggggtgt 300 gctacccagc tcttcttttt taccttcttt attgtaacag aaggtttcat cctggcagtc 360 atggcctatg accgcttcat cgccatctgc aatcctcttc tttatagtat ccacatgtca 420 agacaccttt gcgctcagct ggtgactggc tcctatctct gtggctgggt cagttccatc 480 atccaagtca gcacaacatt ctcagtgtct ttctgtgctt cccgagtcat tgatcacttc 540 tactgtgatt cttaccaaat tgagaagatc tcctgttcca atctctctgt aaacaagatg 600 atatctcttt gtttggctgc cttcatcatt ttgcctacga tagttgttat tgtcgtgtct 660 tacatgtaca ttgtgaccac agtcctgagg attccctcca gtgaagggag aaagaaagcc 720 ttctccacct gcagctccca tttgggagtg gtaagtttgc tgtacgggac agtctccttt 780 gtgtatctca cacctccaag caatcctgaa cttcgtaaag tggcttcggt gttttacata 840 ttggtcacgc ccatgttaaa ccctctgatc tactctctaa gaaacaaaga tgtcaaacaa 900 gcattgggga aaatcctgtg gaagaaaacc actttatatt aa 942 <210> 1564 <211> 313 <212> PRT <213> Canis familiaris <400> 1564

Met Asn Asp Lys Gly Ala Gly Asn Tyr Ser Asp Val Thr Asp Phe Thr 1 5 10 15

Leu Val Gly Phe Arg Val Arg Pro Glu Leu His Ile Leu Leu Phe Leu 20 25 30

Leu Phe Leu Leu Val Tyr Ser Met Val Leu Leu Gly Asn Phe Ser Met 35 40 45

Page 1759

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Ile Gly 50 Ile Ile Val Thr Asp Ser 55 Gln Leu Asn Thr Pro Met Tyr 60 Phe Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Ser Tyr Ser Thr Ile Ile 65 70 75 80 Ala Pro Lys Ala Met Val Asn Phe Leu Ser Glu Lys Asn Thr Val Ser 85 90 95 Phe Leu Gly Cys Ala Thr Gln Leu Phe Phe Phe Thr Phe Phe Ile Val 100 105 110 Thr Glu Gly Phe Ile Leu Ala Val Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Ser Ile His Met Ser Arg His Leu Cys 130 135 140 Ala Gln Leu Val Thr Gly Ser Tyr Leu Cys Gly Trp Val Ser Ser Ile 145 150 155 160 Ile Gln Val Ser Thr Thr Phe Ser Val Ser Phe Cys Ala Ser Arg Val 165 170 175 Ile Asp His Phe Tyr Cys Asp Ser Tyr Gln Ile Glu Lys Ile Ser Cys 180 185 190 Ser Asn Leu Ser Val Asn Lys Met Ile Ser Leu Cys Leu Ala Ala Phe 195 200 205 Ile Ile Leu Pro Thr Ile Val Val Ile Val Val Ser Tyr Met Tyr Ile 210 215 220 Val Thr Thr Val Leu Arg Ile Pro Ser Ser Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Leu Leu Tyr Gly 245 250 255

Page 1760

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Thr Val Ser Phe Val Tyr Leu Thr Pro 265 Pro Ser Asn Pro Glu 270 Leu Arg 260 Lys Val Ala Ser Val Phe Tyr Ile Leu Val Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gln Ala Leu Gly Lys 290 295 300 Ile Leu Trp Lys Lys Thr Thr Leu Tyr 305 310

<210> 1565 <211> 936 <212> DNA <213> Canis familiaris <400> 1565

atgaagagca agctgagcag gaattcctca ggagtgactg agttcattct gctgggcttc 60 agaacagctc cagacataca gatcctctta ttcctattct tcttgctggt ctacgtggtc 120 actgtggtgg gaaatgtcag catgataatt gtcatcagga tggactcgag gcttcacacg 180 cctatgtatt tcttccttag acacttgtcc tatgtagatc tctgctactc cacagtcatt 240 gctcccaaaa ctttagccaa cttcctgtct catgaaaaga agatttccta caatggctgt 300 gcagcccaat ttttcttctt tgctctgttt gtcacaactg aaagcattct tttggctgtc 360 atggccttcg atcgattctc agccatttgc tcccctctcc tttaccctgt gcacatgtcc 420 cagaaagtgt gcgctcagct ggtgactggc tcctacatct gtggaggcct taactccatg 480 gtccacacag gattcacctt cagcttgcgt ttctgtggag aaaaccacct ggatcacttc 540 ttctgtgacg tctcagccct gatcaagatc tcatgtgtag acacgtctgt gaacgagatg 600 gtgctgttca tcctctccgc cctcatcatt gtcaccacca cgactgtcat cctggtttcc 660 tatgcttaca tactctccac tgtcctgaag atcccctcca cccacggcag gggtaagacc 720 ttctccacct gtggctccca catggccacg gtgactttgt tctatgggac cgtgttcttc 780 atgtacgccc agcccggggc catctcctcc ccagggcaaa acaaggtcgt ggctgtgctc 840 tacacactca tcatcccaat gctaaaccct ctgatataca gtctgagaaa cagagacgtg 900

Page 1761

069269_0225_SL.TXT aaagatgctg tgagaagagt gctgcacagg aagtga

936 <210> 1566 <211> 311 <212> PRT <213> Canis familiaris <400> 1566

Met 1 Lys Ser Lys Leu Ser 5 Arg Asn Ser Ser Gly Val Thr Glu Phe Ile 10 15 Leu Leu Gly Phe Arg Thr Ala Pro Asp Ile Gln Ile Leu Leu Phe Leu 20 25 30 Phe Phe Leu Leu Val Tyr Val Val Thr Val Val Gly Asn Val Ser Met 35 40 45 Ile Ile Val Ile Arg Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Arg His Leu Ser Tyr Val Asp Leu Cys Tyr Ser Thr Val Ile 65 70 75 80 Ala Pro Lys Thr Leu Ala Asn Phe Leu Ser His Glu Lys Lys Ile Ser 85 90 95 Tyr Asn Gly Cys Ala Ala Gln Phe Phe Phe Phe Ala Leu Phe Val Thr 100 105 110 Thr Glu Ser Ile Leu Leu Ala Val Met Ala Phe Asp Arg Phe Ser Ala 115 120 125 Ile Cys Ser Pro Leu Leu Tyr Pro Val His Met Ser Gln Lys Val Cys 130 135 140 Ala Gln Leu Val Thr Gly Ser Tyr Ile Cys Gly Gly Leu Asn Ser Met 145 150 155 160 Val His Thr Gly Phe Thr Phe Ser Leu Arg Phe Cys Gly Glu Asn His 165 170 175

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Leu Asp His Phe Phe Cys Asp Val Ser Ala Leu Ile Lys Ile Ser Cys 180 185 190 Val Asp Thr Ser Val Asn Glu Met Val Leu Phe Ile Leu Ser Ala Leu 195 200 205 Ile Ile Val Thr Thr Thr Thr Val Ile Leu Val Ser Tyr Ala Tyr Ile 210 215 220 Leu Ser Thr Val Leu Lys Ile Pro Ser Thr His Gly Arg Gly Lys Thr 225 230 235 240 Phe Ser Thr Cys Gly Ser His Met Ala Thr Val Thr Leu Phe Tyr Gly 245 250 255 Thr Val Phe Phe Met Tyr Ala Gln Pro Gly Ala Ile Ser Ser Pro Gly 260 265 270 Gln Asn Lys Val Val Ala Val Leu Tyr Thr Leu Ile Ile Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Arg Asp Val Lys Asp Ala Val 290 295 300 Arg Arg Val Leu His Arg Lys

305 310 <210> 1567 <211> 963 <212> DNA <213> Canis familiaris <400> 1567 atgggtgaca ggggaaccag caatcgctca gaagtgactg acttcattct tgtaggtttc agggtccgcc ccgagctcta cattctcctc ttcctgctct tcctccttgt gtatgccatg atcctgctgg ggaatgttgg gatggtggcc gttatcctga ctgatcccag gctgaacaca ccgatgtatt tcttcctggg caacctctcc ttcattgacc tcttctactc ctccgtaatt

120

180

240

Page 1763

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gcccccaagg ctatgatcaa cttctggtct gagagcaagt ccatctcctt tgcaggctgt 300 gtgacccagc tctttctctt tgccctcttc attgtggctg aggggtttct cctggctgcc 360 atggcttatg accgcttcat tgccatctgc aacccactcc tctactccgt ccagatgtca 420 acacgcctct gcatccagtt ggtggctggt tcctattttt gtggctgctt cagttctatt 480 cttttgacca gtgtgacatt tactttgtcc ttttgtgctt cccgagccat cgaccacttt 540 tactgtgatt accgtccact tcaaaggatt tcttgctctg atctctactt tcataagata 600 gtttcttttt tcttatgcag cattattatt ttgcccacca tcattgtcat tctcgtgtcc 660 tatatgtata ttgtgtccac agttctaaag ataagatcca ctgagggacg taagaaagcc 720 ttctccactt gcagctctca cctaggagtc gtgagcgtcc tgtacggtgc catcattttt 780 atgtatttca tccctgacag attccctgag ctgagtaaag tggcttcttt atgttatacg 840 ttagtcactc ccatgttgaa tcctttgatt tactccctga gaaacaaaga tgtcaaagag 900 gctctgagaa agatcctggg gaaaaagata tttttattta attccatctt aacagtgata 960

taa 963 <210> 1568 <211> 320 <212> PRT <213> Canis familiaris <400> 1568

Met Gly Asp Arg Gly Thr Ser Asn Arg Ser Glu Val Thr Asp Phe Ile 1 5 10 15 Leu Val Gly Phe Arg Val Arg Pro Glu Leu Tyr Ile Leu Leu Phe Leu 20 25 30 Leu Phe Leu Leu Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 35 40 45 Val Ala Val Ile Leu Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 65 70 75 80

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Ala Pro Lys Ala Met 85 Ile Asn Phe Trp Ser Glu Ser Lys Ser Ile Ser 90 95 Phe Ala Gly Cys Val Thr Gln Leu Phe Leu Phe Ala Leu Phe Ile Val 100 105 110 Ala Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Ser Thr Arg Leu Cys 130 135 140 Ile Gln Leu Val Ala Gly Ser Tyr Phe Cys Gly Cys Phe Ser Ser Ile 145 150 155 160 Leu Leu Thr Ser Val Thr Phe Thr Leu Ser Phe Cys Ala Ser Arg Ala 165 170 175 Ile Asp His Phe Tyr Cys Asp Tyr Arg Pro Leu Gln Arg Ile Ser Cys 180 185 190 Ser Asp Leu Tyr Phe His Lys Ile Val Ser Phe Phe Leu Cys Ser Ile 195 200 205 Ile Ile Leu Pro Thr Ile Ile Val Ile Leu Val Ser Tyr Met Tyr Ile 210 215 220 Val Ser Thr Val Leu Lys Ile Arg Ser Thr Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 245 250 255 Ala Ile Ile Phe Met Tyr Phe Ile Pro Asp Arg Phe Pro Glu Leu Ser 260 265 270 Lys Val Ala Ser Leu Cys Tyr Thr Leu Val Thr Pro Met Leu Asn Pro 275 280 285

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Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys 290 295 300 Ile Leu Gly Lys Lys Ile Phe Leu Phe Asn Ser Ile Leu Thr Val Ile

305 310 315 320 <210> 1569 <211> 942 <212> DNA <213> Canis familiaris <400> 1569

atgggtgaca ggggaacaag caatggctca gaagtgactg acttcattct tgtaggcttc 60 agggtccgcc ccgagctcta cattctcctc ttcctgctct tcctgcttgt gtatgccatg 120 atcctgctgg ggaatgttgg aatggtggcc gttatcctga ctgatcccag gctgaacaca 180 ccgatgtatt tctttctggg caacctctcc ttcattgacc tcttctactc ctctgtaatt 240 gcccccaagg ctatgatcaa cttctggtct gagagcaagt ccatctcctt tgcaggctgt 300 gcgacccagc tctttctctt tgccctcttc attgtggctg aggggtttct cctggctgcc 360 atggcttatg accgcttcat tgccatctgc aacccactcc tctactccgt ccagatgtca 420 acgcgtctct gcattcagtt ggtggctggt tcctattttt gtggctgcat cagctcggtt 480 cttcagacaa gcttgacatt tactttgtct ttttgtgctt cccgggccat tgaccacttt 540 tactgtgaca ctcgtccact tcagaggata tcttgttctg atctgttcat caacaggata 600 atttctttct ccttatctgc catcattatt ttgcctacta tcatagttat tcttatttct 660 tacttgtata ttgtgtccac agttctaaag ataagatcca ctgagggacg taagaaagtt 720 ttctccactt gcagctctca cctaggagtc gtgagtgtcc tgtatggtgc tgtctttttt 780 atgtatctca ctcctgacag atttcctgag ctgagtaaag tggcttcttt atgttatacg 840 ttagtcactc ccatgttgaa tcctttgatt tactccctga gaaacaaaga tgttaaagaa 900 gctctaaaaa aacttcttga gaagaaaaat acaattgttt ga 942

<210> 1570 <211> 313 <212> PRT <213> Canis familiaris

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<400> 1570 Gly Thr Ser Asn Gly Ser Glu Val Thr Asp Phe 15 Ile Met 1 Gly Asp Arg 5 10 Leu Val Gly Phe Arg Val Arg Pro Glu Leu Tyr Ile Leu Leu Phe Leu 20 25 30 Leu Phe Leu Leu Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 35 40 45 Val Ala Val Ile Leu Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 65 70 75 80 Ala Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Ser Lys Ser Ile Ser 85 90 95 Phe Ala Gly Cys Ala Thr Gln Leu Phe Leu Phe Ala Leu Phe Ile Val 100 105 110 Ala Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Ser Thr Arg Leu Cys 130 135 140 Ile Gln Leu Val Ala Gly Ser Tyr Phe Cys Gly Cys Ile Ser Ser Val 145 150 155 160 Leu Gln Thr Ser Leu Thr Phe Thr Leu Ser Phe Cys Ala Ser Arg Ala 165 170 175 Ile Asp His Phe Tyr Cys Asp Thr Arg Pro Leu Gln Arg Ile Ser Cys 180 185 190 Ser Asp Leu Phe Ile Asn Arg Ile Ile Ser Phe Ser Leu Ser Ala Ile 195 200 205

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Ile Ile Leu Pro Thr Ile Ile Val Ile Leu Ile Ser Tyr Leu Tyr Ile 210 215 220 Val Ser Thr Val Leu Lys Ile Arg Ser Thr Glu Gly Arg Lys Lys Val 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 245 250 255 Ala Val Phe Phe Met Tyr Leu Thr Pro Asp Arg Phe Pro Glu Leu Ser 260 265 270 Lys Val Ala Ser Leu Cys Tyr Thr Leu Val Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys 290 295 300 Leu Leu Glu Lys Lys Asn Thr Ile Val

305 310 <210> 1571 <211> 942 <212> DNA <213> Canis familiaris <400> 1571

atgggtgaca agggaggaga caaccactca gaagtgactg acttcattct tgtaggcatc 60 agggtccgtc cagagctcca cagtctcctc ttcctactat tcctggttgt ttatgggatg 120 gtcctcctgg ggaaccttag catgattggc atcattgtga ccgacccccg gctgaacaca 180 ccaatgtatt tcttcctagg caatctttcc atcattgacc tctcctactc cactgttatt 240 gtacccaaag ccatggtcaa catcctgtct cagaaaaaga ccatctcctt tgcaggctgt 300 gtggctcagc tatttcttta cgcgcttttc atggtcacag aggcctttgt cctggcagcc 360 atggcctatg accgcttcat cgccatctgc aacccgctcc tctacactat ccgcatgtca 420 agaagcctct gtatccagtt ggtggctggc tcctatctct gcggctgggt cagctccatc 480

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cttcaaatca gtgtaacctt ctcaatgtct ttctgtgctt cccgagtcat tgatcacttc 540 tactgtgatt caaacccaat tgagaagatc tcctgttcca atatctttat gaataagatg 600 gtgtcattta gtctggctgt cctcattatt ttgcccacga tagttgttat tgtggtatcg 660 tatatgtata ttgtgtctgc agttttaaaa atccgctcta gtgaagggag gaagaaagcc 720 ttctccacct gcagctccca cctgggggtt gtaagtttgc tctatgggac agtctccttt 780 gtctatctca cacccccaag taaccctgaa cttcgtaaag tggcttcagt atgttacatt 840 ttgttcacac ctatgctgaa ccctttaatc tactctctaa gaaataagga tgttaaagat 900 gccatgaaaa aagtcctatg gaagaaaaaa gttttacttt aa 942

<210> 1572 <211> 313 <212> PRT <213> Canis familiaris

<400> 1572 Gly Asp Asn His Ser Glu Val Thr Asp Phe Ile Met Gly 1 Asp Lys Gly 5 10 15 Leu Val Gly Ile Arg Val Arg Pro Glu Leu His Ser Leu Leu Phe Leu 20 25 30 Leu Phe Leu Val Val Tyr Gly Met Val Leu Leu Gly Asn Leu Ser Met 35 40 45 Ile Gly Ile Ile Val Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Ile Ile Asp Leu Ser Tyr Ser Thr Val Ile 65 70 75 80 Val Pro Lys Ala Met Val Asn Ile Leu Ser Gln Lys Lys Thr Ile Ser 85 90 95 Phe Ala Gly Cys Val Ala Gln Leu Phe Leu Tyr Ala Leu Phe Met Val 100 105 110

Thr Glu Ala Phe Val

Leu Ala Ala

Met Ala Tyr Asp Arg Page 1769

Phe

Ile Ala

069269_0225_SL.TXT

115 120 125 Ile Cys Asn Pro Leu Leu Tyr Thr Ile Arg Met Ser Arg Ser Leu Cys 130 135 140 Ile Gln Leu Val Ala Gly Ser Tyr Leu Cys Gly Trp Val Ser Ser Ile 145 150 155 160 Leu Gln Ile Ser Val Thr Phe Ser Met Ser Phe Cys Ala Ser Arg Val 165 170 175 Ile Asp His Phe Tyr Cys Asp Ser Asn Pro Ile Glu Lys Ile Ser Cys 180 185 190 Ser Asn Ile Phe Met Asn Lys Met Val Ser Phe Ser Leu Ala Val Leu 195 200 205 Ile Ile Leu Pro Thr Ile Val Val Ile Val Val Ser Tyr Met Tyr Ile 210 215 220 Val Ser Ala Val Leu Lys Ile Arg Ser Ser Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Leu Leu Tyr Gly 245 250 255 Thr Val Ser Phe Val Tyr Leu Thr Pro Pro Ser Asn Pro Glu Leu Arg 260 265 270 Lys Val Ala Ser Val Cys Tyr Ile Leu Phe Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Met Lys Lys 290 295 300 Val Leu Trp Lys Lys Lys Val Leu Leu 305 310

<210> 1573

Page 1770

069269_0225_SL.TXT <211> 447 <212> DNA <213> Canis familiaris <400> 1573 tttctttgaa tactgatgac taaagagctg aaagtttgag ggcagttgtt ggtatttgct 60 ataaactgct agagattcaa tccctccacc cactcagtgg gttctctaga ggagtctttg 120 cttctttcag gccaagagaa gttcttagag aaaacatctc atggcctaaa gcccagaata 180 ttgagtagct ccagtaacgt ttgcattgtt cagttattgt ttttcattct gttgggagtc 240 actgaatttt acctgctggc tgccatgtcc tatgaccaat acaatgccat ctgcaaacct 300 gtgcattaca tgaccatcat gaatcagagt ctgcatactc cttgcttact cttcatggct 360 gatttccttc ttaatcatat tccctgtgct catgttgctc ttaattactg taggcctgat 420 attattgacc atttcacctg tgattat 447 <210> 1574 <211> 61 <212> PRT <213> Canis familiaris

<400> 1574 Tyr Met 15 Met 1 Ser Tyr Asp Gln 5 Tyr Asn Ala Ile Cys 10 Lys Pro Val His Thr Ile Met Asn Gln Ser Leu His Thr Pro Cys Leu Leu Phe Met Ala 20 25 30 Asp Phe Leu Leu Asn His Ile Pro Cys Ala His Val Ala Leu Asn Tyr 35 40 45 Cys Arg Pro Asp Ile Ile Asp His Phe Thr Cys Asp Tyr 50 55 60

<210> 1575 <211> 975 <212> DNA <213> Canis familiaris <400> 1575 atgagaaacc atacaatgat tacagagttc gttctcttgg gcatctcaga tgacccacag 60

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cttcaggttg taatctttat ctttttattt atggcttatg tattaagtgt cactggaaac 120 ctaaccatca tcatcctcac cttgatagac tgtcatctca agactcctat ttattatttc 180 ctgcagaatt tctccttctt agaaattaca ttcaccagtg tttgtatccc cagatttttg 240 gggacaatcg ttactaaaat caagactgtt tcctataaca gttgtgtagc tcaactattt 300 tttatcatcc tcacgggtgt tactgaattt ccccttctca ctgtcatggc ttttgatcgt 360 tatgttgcca tctgtaagcc tcttcattat atcatcatca tgaacaagaa aatctgtacc 420 ctgcttgtct ttgggtcctg gttactagga tttcttacca ttttcccacc actcatcctc 480 atcctccagc tagatttctg tgcttccaac gtaattgatc atttctgttg tgactatttc 540 cccattttac aactctcatg ctcagataca tggcttttag agatgattgg cttttacttc 600 gcttttgtta ttcttttctt cacattggca ttagtgattc aatcctacgt gagcatcctt 660 agcaccattc tgagactccc atctgctagt caaaggaaaa aggctttatc cacgtgttcc 720 tctcacttga ttgtcatttc catctcttat gggagctgta tattcatgta tgtcaagcct 780 tcagcaaaag aaagagcatc actgaccaaa ggagtagcta ttctcaacac ctcgattgcc 840 cccatgttga acccttttat ttataccctg aggaaccagc aagttaaaca agctttgaag 900 aacttgcttc acaaagtagc attttctatc agagagggag acaaaacatg gaagactcct 960 aactctggga aatga 975

<210> 1576 <211> 324 <212> PRT <213> Canis familiaris <400> 1576

Met Arg Asn His Thr Met Ile Thr Glu Phe Val Leu Leu Gly Ile Ser 1 5 10 15 Asp Asp Pro Gln Leu Gln Val Val Ile Phe Ile Phe Leu Phe Met Ala 20 25 30 Tyr Val Leu Ser Val Thr Gly Asn Leu Thr Ile Ile Ile Leu Thr Leu 35 40 45 Ile Asp Cys His Leu Lys Thr Pro Ile Tyr Tyr Phe Leu Gln Asn Phe Page 1772

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50 55 60 Ser Phe Leu Glu Ile Thr Phe Thr Ser Val Cys Ile Pro Arg Phe Leu 65 70 75 80 Gly Thr Ile Val Thr Lys Ile Lys Thr Val Ser Tyr Asn Ser Cys Val 85 90 95 Ala Gln Leu Phe Phe Ile Ile Leu Thr Gly Val Thr Glu Phe Pro Leu 100 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Ile Ile Ile Met Asn Lys Lys Ile Cys Thr Leu Leu Val Phe 130 135 140 Gly Ser Trp Leu Leu Gly Phe Leu Thr Ile Phe Pro Pro Leu Ile Leu 145 150 155 160 Ile Leu Gln Leu Asp Phe Cys Ala Ser Asn Val Ile Asp His Phe Cys 165 170 175 Cys Asp Tyr Phe Pro Ile Leu Gln Leu Ser Cys Ser Asp Thr Trp Leu 180 185 190 Leu Glu Met Ile Gly Phe Tyr Phe Ala Phe Val Ile Leu Phe Phe Thr 195 200 205 Leu Ala Leu Val Ile Gln Ser Tyr Val Ser Ile Leu Ser Thr Ile Leu 210 215 220 Arg Leu Pro Ser Ala Ser Gln Arg Lys Lys Ala Leu Ser Thr Cys Ser 225 230 235 240 Ser His Leu Ile Val Ile Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Val Lys Pro Ser Ala Lys Glu Arg Ala Ser Leu Thr Lys Gly Val

Page 1773

260

069269_0225_SL.TXT 265 270

Ala Ile Leu Asn Thr Ser Ile Ala Pro Met 280 Leu Asn Pro 285 Phe Ile Tyr 275 Thr Leu Arg Asn Gln Gln Val Lys Gln Ala Leu Lys Asn Leu Leu His 290 295 300 Lys Val Ala Phe Ser Ile Arg Glu Gly Asp Lys Thr Trp Lys Thr Pro 305 310 315 320

Asn Ser Gly Lys <210> 1577 <211> 939 <212> DNA <213> Canis familiaris <400> 1577

atgaggaatc agtcaacaaa gatcgagttc attctcctgg gactgaccga tgacccacaa 60 ctgcaaattg tgatttttac atttctcttc atcaactatg tgctgagcat gactggaaac 120 ttaaccatca tccttctcac cctgctacat cccagcctca agactcccat gtattttttc 180 ctccgaaatt tctcctttat ggaagcttca ctgacaacag tctgtattcc cagattcctg 240 ataagcctca taactaaaaa caaagtcatt tcctacaatt gttgtgcatc tcagttattc 300 tttttcctcc aattagaaat tgcagaattt tacctgctgg ctgccatgtc ctttgaccgt 360 tatgtagcaa tctgcaaacc cctgcattac ctgatcatca tgaacaacaa aatgtgctac 420 caactcctgt tcagctcatg ggccgtgggc tttctgctat cgtttccacc attggctgtg 480 ggcctcacac tggatttctg tgcttccaga gtaatcgatc atttcatgtg tgacatttcc 540 cctgtgctgc agctttcctg cactgacact cgtttcttgg aattgctttc gtttgtctta 600 tctcttgtaa cacttctgat cacgttgctg ttactgattc tttcttacac atacattatc 660 aagaccattc tcaagatccc ctctgctcag aaaagaacca aggctttttc tacttgttct 720 tctcatatga ttgtggtctc ccttacgtat ggtagctgca tctttaatta cctaaagcca 780 acagcgaagg aaagggtgac tttgtccaaa ggtgtaagtg ttatttatac ctcggttgcc 840

Page 1774

069269_0225_SL.TXT cctttattaa accctttcat ttacagtctc agaaaccaac aagtcaaaca agccttcaag gatgcacgcc aaaagatttg ctctttttcc aaaaaatga

900

939 <210> 1578 <211> 312 <212> PRT <213> Canis familiaris

<400> 1578 Thr Lys Ile Glu Phe Ile Leu Leu Gly Leu Thr Met Arg 1 Asn Gln Ser 5 10 15 Asp Asp Pro Gln Leu Gln Ile Val Ile Phe Thr Phe Leu Phe Ile Asn 20 25 30 Tyr Val Leu Ser Met Thr Gly Asn Leu Thr Ile Ile Leu Leu Thr Leu 35 40 45 Leu His Pro Ser Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Met Glu Ala Ser Leu Thr Thr Val Cys Ile Pro Arg Phe Leu 65 70 75 80 Ile Ser Leu Ile Thr Lys Asn Lys Val Ile Ser Tyr Asn Cys Cys Ala 85 90 95 Ser Gln Leu Phe Phe Phe Leu Gln Leu Glu Ile Ala Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Ile Ile Met Asn Asn Lys Met Cys Tyr Gln Leu Leu Phe 130 135 140 Ser Ser Trp Ala Val Gly Phe Leu Leu Ser Phe Pro Pro Leu Ala Val 145 150 155 160

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Gly Leu Thr Leu Asp Phe Cys Ala Ser Arg 170 Val Ile Asp His Phe 175 Met 165 Cys Asp Ile Ser Pro Val Leu Gln Leu Ser Cys Thr Asp Thr Arg Phe 180 185 190 Leu Glu Leu Leu Ser Phe Val Leu Ser Leu Val Thr Leu Leu Ile Thr 195 200 205 Leu Leu Leu Leu Ile Leu Ser Tyr Thr Tyr Ile Ile Lys Thr Ile Leu 210 215 220 Lys Ile Pro Ser Ala Gln Lys Arg Thr Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Val Ser Leu Thr Tyr Gly Ser Cys Ile Phe Asn 245 250 255 Tyr Leu Lys Pro Thr Ala Lys Glu Arg Val Thr Leu Ser Lys Gly Val 260 265 270 Ser Val Ile Tyr Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asp Ala Arg Gln 290 295 300 Lys Ile Cys Ser Phe Ser Lys Lys 305 310 <210> 1579 <211> 945 <212> DNA <213> Canis familiaris <400> 1579 atgaaaaacc attcaacgga aatagagttt attctcctag gactgacaga tgacccacaa ttgcaagttg tgatttttgt gtttttattt cttaattaca ctttgagcct gatggggaac ttaaccatta tcctcctcac cctgctggat cctcgcctca agatgccaat gtatttcttt

120

180

Page 1776

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ctccgtaatt tctcatttct agaaatcata ttcacaacgg tatgtattcc cagatacttg 240 aaaaccatag tgactaaaga aaaaaccatc tcatataata attgtgcggc tcaattattt 300 tttattcttt tactgggagt tacagagttt taccttctgg ctgctatgtc ctatgaccgc 360 tatgttgcca tctgcaaacc cttgcattac ccaatcatta tgaacagccg agtgtgctat 420 cagcttgtac ttgcttcttg gctgactgga ttcctaatca tctttccccc attgctcatg 480 ggactcaagc tggatttctg tgcttccaaa acgattgatc actttatgtg tgaaacttcc 540 cccatcctgc agatatcctg cacagacaca catgtcctag aattgatgtc tttcatcttc 600 gccgtggtga cacttgtggt cacattggtg ttagtggttc tctcctacac ttgcatcatg 660 aagaccatta tgaaattccc ttctgcacag caaagggcca aagctttttc cacctgtact 720 tcccatatga ttgttgtctc catgacatat gggagctgca tctttatgta tattaagcca 780 tctgccaaag aaagggtgac tgtatccaaa ggtgtagctt tgctgtatac ctcaatcgcc 840 cctttactaa atcccttcat ttatacccta aggaaccagc aggtgaaaga agtcttctgg 900 gatatgttac aaaaaaggtt gtatttttca aaaaaaaaat tgtga 945

<210> 1580 <211> 314 <212> PRT <213> Canis familiaris <400> 1580

Met 1 Lys Asn His Ser Thr 5 Glu Ile Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Asp Asp Pro Gln Leu Gln Val Val Ile Phe Val Phe Leu Phe Leu Asn 20 25 30 Tyr Thr Leu Ser Leu Met Gly Asn Leu Thr Ile Ile Leu Leu Thr Leu 35 40 45 Leu Asp Pro Arg Leu Lys Met Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ile Phe Thr Thr Val Cys Ile Pro Arg Tyr Leu 65 70 75 80

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Lys Thr Ile Val Thr 85 Lys Glu Lys Thr Ile Ser Tyr Asn Asn Cys Ala 90 95 Ala Gln Leu Phe Phe Ile Leu Leu Leu Gly Val Thr Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Pro Ile Ile Met Asn Ser Arg Val Cys Tyr Gln Leu Val Leu 130 135 140 Ala Ser Trp Leu Thr Gly Phe Leu Ile Ile Phe Pro Pro Leu Leu Met 145 150 155 160 Gly Leu Lys Leu Asp Phe Cys Ala Ser Lys Thr Ile Asp His Phe Met 165 170 175 Cys Glu Thr Ser Pro Ile Leu Gln Ile Ser Cys Thr Asp Thr His Val 180 185 190 Leu Glu Leu Met Ser Phe Ile Phe Ala Val Val Thr Leu Val Val Thr 195 200 205 Leu Val Leu Val Val Leu Ser Tyr Thr Cys Ile Met Lys Thr Ile Met 210 215 220 Lys Phe Pro Ser Ala Gln Gln Arg Ala Lys Ala Phe Ser Thr Cys Thr 225 230 235 240 Ser His Met Ile Val Val Ser Met Thr Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Lys Pro Ser Ala Lys Glu Arg Val Thr Val Ser Lys Gly Val 260 265 270 Ala Leu Leu Tyr Thr Ser Ile Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285

Page 1778

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Thr Leu Arg Asn Gln Gln Val Lys Glu Val Phe Trp Asp Met Leu Gln 290 295 300

Lys Arg Leu Tyr Phe Ser Lys Lys Lys Leu

305 310 <210> 1581 <211> 939 <212> DNA <213> Canis familiaris <400> 1581

atgggaaatc acacacaagg gatagtgttt atcctggcag gtctgactga tgatccacaa 60 ctgaaagtta cgctatttgt cttcctgctt ctcacctact tgctgagcat ctctggcaac 120 ttaaccatca tcacactcac cctggtggat actcatctca agacccccat gtattttttc 180 cttcggaatt tttccttctt agaaatttcc tatactacta catgcatccc taaattgttg 240 gttactatgg caactggaga caaaaccatt tcctataata attgcattac tcaattgttt 300 tttgccttcc ttcttggtgc atctgaattt tacttgctgg cagctatgtc ctatgaccgc 360 tatgttgcca tttgtaagcc cctgcattac acaaccatca tgagcagtaa gatctgcatg 420 caacttgtct tctgttgttg gcttgcagga ttctttacca tctttgtacc cctcctattg 480 ggtctaaacc ttgacttctg tgcttcccac attgttgatc acttctactg tgacacaaca 540 cccctgctgc agatctcctg ctcggacaca cagctcttag agacaatggg atttatttct 600 gcatcgatga cacttgtggt cacattaatc atggtgataa tatcctatac ctttattgca 660 ttaacaatcc taaaaatacc ttcaactaaa cagaagaaaa aggctttttc aacatgttct 720 tctcacatga ttgtgatatc cctttcttac ggcagctgca tcttcatgta tgttaagcca 780 tcggtcaaac aaagaatatc tttctccaag ggaattgcag tgctcaacac ctccgtggct 840 ccacttttga atcctttcat ctatactctg aggaaccagc aagtaaaaac agccttcatg 900 aacatggtac aaagggttgt ttctttctta agcaaatga 939

<210> 1582 <211> 312 <212> PRT <213> Canis familiaris

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<400> 1582 Thr Gln Gly Ile Val Phe Ile Leu Ala Gly Leu 15 Thr Met 1 Gly Asn His 5 10 Asp Asp Pro Gln Leu Lys Val Thr Leu Phe Val Phe Leu Leu Leu Thr 20 25 30 Tyr Leu Leu Ser Ile Ser Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Val Asp Thr His Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Tyr Thr Thr Thr Cys Ile Pro Lys Leu Leu 65 70 75 80 Val Thr Met Ala Thr Gly Asp Lys Thr Ile Ser Tyr Asn Asn Cys Ile 85 90 95 Thr Gln Leu Phe Phe Ala Phe Leu Leu Gly Ala Ser Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Ser Ser Lys Ile Cys Met Gln Leu Val Phe 130 135 140 Cys Cys Trp Leu Ala Gly Phe Phe Thr Ile Phe Val Pro Leu Leu Leu 145 150 155 160 Gly Leu Asn Leu Asp Phe Cys Ala Ser His Ile Val Asp His Phe Tyr 165 170 175 Cys Asp Thr Thr Pro Leu Leu Gln Ile Ser Cys Ser Asp Thr Gln Leu 180 185 190 Leu Glu Thr Met Gly Phe Ile Ser Ala Ser Met Thr Leu Val Val Thr 195 200 205

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Leu Ile Met Val Ile Ile Ser Tyr Thr Phe Ile Ala Leu Thr Ile Leu 210 215 220 Lys Ile Pro Ser Thr Lys Gln Lys Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Ile Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Val Lys Pro Ser Val Lys Gln Arg Ile Ser Phe Ser Lys Gly Ile 260 265 270 Ala Val Leu Asn Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Gln Gln Val Lys Thr Ala Phe Met Asn Met Val Gln 290 295 300 Arg Val Val Ser Phe Leu Ser Lys

305 310 <210> 1583 <211> 645 <212> DNA <213> Canis familiaris <400> 1583

caactgtttt ttaccttcct tcttggtgca tctgaatttt gcttgctgcc agctatgtcc 60 tatgaccgct atgttgccat ttgtaagccc ctgcattaca caaccatcat gagcagtaag 120 atctgcatgc aacttgtctt ctgttgttgg cttgctgggt cttttgtcat ctttccacct 180 ctcctcttag gcttaaattt tgacttctct gctttcaata ttgttgatca tttctactgt 240 gccacaacct ccctgctgca gatctcctgc tcagacacac agctcttagt gacaatggga 300 tccatctctg ctttggtgac actcatagtc acattggtaa tggtgataat atcatatacc 360 tatattgcat taagaattct aaaaatcctt tcagtcaatc agaggaaaaa ggctttttca 420 acatgttctt ctcacatgat tatgatatcc ctttcttacg gcagctgcat cttcatgtat 480

Page 1781

069269_0225_SL.TXT gttaagccat tagtcaaaca aagaacatct ttttccaagg gaattgcagt gctcaacacc tccgtggctc cacttttgaa tcctttcatc tacattttgt ggaaccagca agtaaaaacg gccttcatga acatggtaca caaaattgtt tctttcccaa acaaa

540

600

645 <210> 1584 <211> 215 <212> PRT <213> Canis familiaris

<400> 1584 Ala Ser 10 Glu Phe Cys Leu Leu 15 Gln Leu 1 Phe Phe Thr Phe 5 Leu Leu Gly Pro Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His 20 25 30 Tyr Thr Thr Ile Met Ser Ser Lys Ile Cys Met Gln Leu Val Phe Cys 35 40 45 Cys Trp Leu Ala Gly Ser Phe Val Ile Phe Pro Pro Leu Leu Leu Gly 50 55 60 Leu Asn Phe Asp Phe Ser Ala Phe Asn Ile Val Asp His Phe Tyr Cys 65 70 75 80 Ala Thr Thr Ser Leu Leu Gln Ile Ser Cys Ser Asp Thr Gln Leu Leu 85 90 95 Val Thr Met Gly Ser Ile Ser Ala Leu Val Thr Leu Ile Val Thr Leu 100 105 110 Val Met Val Ile Ile Ser Tyr Thr Tyr Ile Ala Leu Arg Ile Leu Lys 115 120 125 Ile Leu Ser Val Asn Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser 130 135 140 His Met Ile Met Ile Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met Tyr 145 150 155 160

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Val Lys Pro Leu Val Lys Gln Arg Thr Ser Phe Ser Lys Gly Ile Ala 165 170 175 Val Leu Asn Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr Ile 180 185 190 Leu Trp Asn Gln Gln Val Lys Thr Ala Phe Met Asn Met Val His Lys 195 200 205 Ile Val Ser Phe Pro Asn Lys 210 215

<210> 1585 <211> 201 <212> DNA <213> Canis familiaris <400> 1585

gtgggaaacc acatgcaagg gatagtgttt atcctggcag gtctgactga tgatccacaa 60 ttgaaagttg tgttatttgt cttcctgctt ctcacctact tgctgagcat ctttggcaac 120 ttaaccatca tcacactcac cctggtggat actcatctca agacccccat gtattttttc 180 cttctcaaaa atttcctata c 201

<210> 1586 <211> 67 <212> PRT <213> Canis familiaris <400> 1586

Val Gly Asn His Met Gln Gly Ile Val Phe Ile Leu Ala Gly Leu Thr 1 5 10 15 Asp Asp Pro Gln Leu Lys Val Val Leu Phe Val Phe Leu Leu Leu Thr 20 25 30 Tyr Leu Leu Ser Ile Phe Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Val Asp Thr His Leu Lys Thr Pro Met Tyr Phe Phe Leu Leu Lys Asn 50 55 60

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Phe Leu Tyr <210> 1587 <211> 939 <212> DNA <213> Canis familiaris <400> 1587

atgagaaacc acaccacagt aacaactttt attcttcttg gactgactga taatccacaa 60 ttgcaagtgg tcattttcct tctcctgttt ttcacataca tgttgagtgt cactatgaat 120 ctaaccataa tcatcctcac cctactggat tctcatctaa aaacacccat gtatttcttc 180 ctccgaagtt tctcattttt agaggtctca ttcacaactg tctgcatccc caaatttctt 240 gtcagcatgg caacgggtga taggaccatt tcttacaaca gttgtgcgac acagctgttt 300 tttactattg tcttgggtgc aattgaattt tttcttctgg ctgccatgtc ttatgaccgc 360 tatgttgcca tttgcaaacc cctgcattac accaccatca tgaatgacag agtctgcaac 420 ttgttggtct ttgcttcatg gttagctggt tttatagtag tcgttccacc actccttgtg 480 ggtctccagc tagatttctg tgccgccaac actatagatc atttcttctg tgatttttct 540 cctatattac agctctcttg cacagataca gatgtaatag aattaatggc gcttctctca 600 gccattttga ccctcctggt tacactggta ttagtgatcc tctcctatgc aaacatcatc 660 aggactattc tgaagatacc ttcttctcaa caaaggaaga aagccttttc tacatgttct 720 tctcacatgg tggttgtatc catttcatat ggcagctgca tcttcatgta tgtgaaaccc 780 tctgcaaagg atagagtatc tttaaataaa gggatagccc tgctcagtac ctctgttgcc 840 cccatgttga atcccttcat ttatacactg agaaacaaac aagtgaaaga tgcttttatg 900 cacatgacca aaaagatgga gattttctca gtgaagtga 939

<210> 1588 <211> 312 <212> PRT <213> Canis familiaris <400> 1588

Met Arg Asn His Thr Thr Val Thr Thr Phe Ile Leu Leu Gly Leu Thr Page 1784

0 6926 9_02 25_S L.TX T 1 5 10 15 Asp Asn Pro Gln Leu Gln Val Val Ile Phe Leu Leu Leu Phe Phe Thr 20 25 30 Tyr Met Leu Ser Val Thr Met Asn Leu Thr Ile Ile Ile Leu Thr Leu 35 40 45 Leu Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Ser Phe 50 55 60 Ser Phe Leu Glu Val Ser Phe Thr Thr Val Cys Ile Pro Lys Phe Leu 65 70 75 80 Val Ser Met Ala Thr Gly Asp Arg Thr Ile Ser Tyr Asn Ser Cys Ala 85 90 95 Thr Gln Leu Phe Phe Thr Ile Val Leu Gly Ala Ile Glu Phe Phe Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Asn Asp Arg Val Cys Asn Leu Leu Val Phe 130 135 140 Ala Ser Trp Leu Ala Gly Phe Ile Val Val Val Pro Pro Leu Leu Val 145 150 155 160 Gly Leu Gln Leu Asp Phe Cys Ala Ala Asn Thr Ile Asp His Phe Phe 165 170 175 Cys Asp Phe Ser Pro Ile Leu Gln Leu Ser Cys Thr Asp Thr Asp Val 180 185 190 Ile Glu Leu Met Ala Leu Leu Ser Ala Ile Leu Thr Leu Leu Val Thr 195 200 205 Leu Val Leu Val Ile Leu Ser Tyr Ala Asn Ile Ile Arg Thr Ile Leu

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210 215 Lys Lys 220 Ala Phe Ser Thr Cys Ser Lys 225 Ile Pro Ser Ser Gln 230 Gln Arg 235 240 Ser His Met Val Val Val Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Val Lys Pro Ser Ala Lys Asp Arg Val Ser Leu Asn Lys Gly Ile 260 265 270 Ala Leu Leu Ser Thr Ser Val Ala Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Lys Asp Ala Phe Met His Met Thr Lys 290 295 300 Lys Met Glu Ile Phe Ser Val Lys 305 310

<210> 1589 <211> 936 <212> DNA <213> Canis familiaris <400> 1589 atggctttga ggaaccacag caccatcaca gagttcatcc tccttgggct gtctgttgac 60 tctcacatcc aggttctgct ctttgtgctt ttccttggga tttacctctt gactattttg 120 ggaaatttat tgatgctgtt ggtcatcaag gctgattccc acctccacac acctatgtac 180 ttcttcctga gtcacctctc tctcacggac ttttgtttct ctactgccat agtgcccagg 240 ttgctggaga acctcctgtc ccagaggaaa accatctcag tggagggctg cctggctcaa 300 gtcttctttc tgtttgactt tggaggaaca gaagtctgcc tactgtcagc aatggcctat 360 gatcgttatg ctgctatctg tcatccactc ctctatggcc aggtgatgaa taatcagctg 420 tatatgcagc ttgtatgggg ttcatggagc ctggggtttc tagatgcact cattaacatc 480 accttagtaa caaacctgga tttctgtaag gcccatacca tcccccacta tagctgtgag 540 ctgccctccc ttttcccttt gtcctgctct gatgtctcta ccaacctcac tgtcctgctc 600

Page 1786

069269_0225_SL.TXT tgttccacac tcctgcatgg ctttggtaca ttcttcctga tattcttctc ctatgcacgc attgtctcca ccatcctgag catcagctcc tcctcaggca gaagcaaggc cttctccacc tgctcctccc acctcactgc agtgagcttc ttctatggct cagctttcct gcgtcatctc atgccaacct caggctcacc tctggagctg atcttctcca tacagtatag tgtggtaact cccctagtaa accccttcat ctacagcctg aaaaacaggg agattaaaaa tgcactgaga agaaccttgg ggaagttttt gcaacagtac aggtag

660

720

780

840

900

936 <210> 1590 <211> 311 <212> PRT <213> Canis familiaris <400> 1590

Met Ala Leu Arg Asn His Ser Thr Ile Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Val Asp Ser His Ile Gln Val Leu Leu Phe Val Leu Phe Leu 20 25 30 Gly Ile Tyr Leu Leu Thr Ile Leu Gly Asn Leu Leu Met Leu Leu Val 35 40 45 Ile Lys Ala Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Leu Thr Asp Phe Cys Phe Ser Thr Ala Ile Val Pro Arg 65 70 75 80 Leu Leu Glu Asn Leu Leu Ser Gln Arg Lys Thr Ile Ser Val Glu Gly 85 90 95 Cys Leu Ala Gln Val Phe Phe Leu Phe Asp Phe Gly Gly Thr Glu Val 100 105 110 Cys Leu Leu Ser Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125

Page 1787

Pro Leu 130 Leu Tyr Gly Gln Val 135 069269_0225_SL.TXT Met Asn Asn Gln Leu Tyr 140 Met Gln Leu Val Trp Gly Ser Trp Ser Leu Gly Phe Leu Asp Ala Leu Ile Asn Ile 145 150 155 160 Thr Leu Val Thr Asn Leu Asp Phe Cys Lys Ala His Thr Ile Pro His 165 170 175 Tyr Ser Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Ser Asp Val 180 185 190 Ser Thr Asn Leu Thr Val Leu Leu Cys Ser Thr Leu Leu His Gly Phe 195 200 205 Gly Thr Phe Phe Leu Ile Phe Phe Ser Tyr Ala Arg Ile Val Ser Thr 210 215 220 Ile Leu Ser Ile Ser Ser Ser Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ser Phe Phe Tyr Gly Ser Ala Phe 245 250 255 Leu Arg His Leu Met Pro Thr Ser Gly Ser Pro Leu Glu Leu Ile Phe 260 265 270 Ser Ile Gln Tyr Ser Val Val Thr Pro Leu Val Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Lys Asn Arg Glu Ile Lys Asn Ala Leu Arg Arg Thr Leu Gly 290 295 300 Lys Phe Leu Gln Gln Tyr Arg

305 310 <210> 1591 <211> 936 <212> DNA <213> Canis familiaris

Page 1788

069269_0225_SL.TXT <400> 1591

atggccttgg gaaaccacag caccatcact gaattcctcc ttcttggact gcctgctgat 60 catcataccc aggccctaat ctttgtgctt ttcctggtaa tttacctcct gactctgtca 120 gggaacctgc tgatgatctt ggttatcaga gctaactcac actttcacac acccatgtac 180 ttcttcttga atcacctctc cttcctggat ctctgttact cttcggtcac tgttcccaag 240 atgctagaga acctcctgtc tgagaagaaa accatttcag tggaggactg tttgacgcag 300 gccttctttg tgcttgcctc tgggggaaca gagctctgcc tccttgcagt gatggcatat 360 gaccgctatg ctgccatttg ctaccctcta ctctatggtc agatgatgaa caatgagctg 420 tgtgtgggac tggtatgggg atcttggggt ctggcctttt tggatgcatt catcaatacc 480 ctcctagctt ggaatttgga cttctgtgag actcaagtca tctcgaattt catttgtgag 540 attccttctc tgttccctct atcctgttcc aatagctctg ttaactttgt agtcctgctc 600 tgctctgccc tcctgcatgc ctttgggacc ttcattctgg tcttcttctc ttatacacgc 660 attgttgcca ccatcctaag catcagctct acctcaggca gacacaaggc cttctccacc 720 tgctcctccc acctcaccac agtgagctta ttttatggct caggttttct tcgctatctc 780 atgccaacct caggttctcc atgggagttg gttttttcca tgcagtacag tgtggtcact 840 cccctagtga atccccttgt ctacagcctt aaaaacaagg aagttaaagc agctctgaaa 900 aacatgttgc agaaacattt aaaacgtctt agatag 936

<210> 1592 <211> 311 <212> PRT <213> Canis familiaris <400> 1592

Met 1 Ala Leu Gly Asn His Ser Thr Ile Thr Glu Phe Leu Leu Leu 15 Gly 5 10 Leu Pro Ala Asp His His Thr Gln Ala Leu Ile Phe Val Leu Phe Leu 20 25 30 Val Ile Tyr Leu Leu Thr Leu Ser Gly Asn Leu Leu Met Ile Leu Val

35 40 45

Page 1789

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Ile Arg 50 Ala Asn Ser His Phe His 55 Thr Pro Met Tyr Phe Phe Leu 60 Asn His Leu Ser Phe Leu Asp Leu Cys Tyr Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Asn Leu Leu Ser Glu Lys Lys Thr Ile Ser Val Glu Asp 85 90 95 Cys Leu Thr Gln Ala Phe Phe Val Leu Ala Ser Gly Gly Thr Glu Leu 100 105 110 Cys Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Tyr 115 120 125 Pro Leu Leu Tyr Gly Gln Met Met Asn Asn Glu Leu Cys Val Gly Leu 130 135 140 Val Trp Gly Ser Trp Gly Leu Ala Phe Leu Asp Ala Phe Ile Asn Thr 145 150 155 160 Leu Leu Ala Trp Asn Leu Asp Phe Cys Glu Thr Gln Val Ile Ser Asn 165 170 175 Phe Ile Cys Glu Ile Pro Ser Leu Phe Pro Leu Ser Cys Ser Asn Ser 180 185 190 Ser Val Asn Phe Val Val Leu Leu Cys Ser Ala Leu Leu His Ala Phe 195 200 205 Gly Thr Phe Ile Leu Val Phe Phe Ser Tyr Thr Arg Ile Val Ala Thr 210 215 220 Ile Leu Ser Ile Ser Ser Thr Ser Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Thr Val Ser Leu Phe Tyr Gly Ser Gly Phe 245 250 255

Page 1790

069269_0225_SL.TXT

Leu Arg Tyr Leu 260 Met Pro Thr Ser Gly Ser Pro Trp Glu Leu Val Phe 265 270 Ser Met Gln Tyr Ser Val Val Thr Pro Leu Val Asn Pro Leu Val Tyr 275 280 285 Ser Leu Lys Asn Lys Glu Val Lys Ala Ala Leu Lys Asn Met Leu Gln 290 295 300 Lys His Leu Lys Arg Leu Arg

305 310 <210> 1593 <211> 639 <212> DNA <213> Canis familiaris <400> 1593

gatccccatt tccctgcctc catgtacttc ttcctcaatc acttctcttt actggatctt 60 tgctattcct tagtcaccat acccaaaatg ctggagaaac tcttgtttca gaggaaatca 120 atctcagtag aggctgactc aggtttatgt atgtgtgtgt gttgtactgc agggattgag 180 gcttttctgc tctaagtgat gacttataac cactctactg cctgccatct gccacctcct 240 gctctgtggt cagcctatga gtaaacagtt gtgtaggtct catggagact agaatttggg 300 atgttcatgg cttggaattt ggacttctgt gaggctcacg ttatgcctta cttcagttgt 360 cagctgcctc ttctatttcc tctgttctgc tctgatatct ccaccaaatt tgcagtcctc 420 atgtgctctg ccatcattca tgcccttttg accatcctcc taatcctctt ctcttccact 480 tacattatta ccatcctcct gagcattagc tccatcacag gcagaagcaa ggccttctcc 540 acctgctcct cccacctcaa tgcaacgact ttttcttaag gctcaagttt tctttactat 600 ctcaggctaa cctctggttc cccactggag gtggttttt 639

<210> 1594 <211> 64 <212> PRT <213> Canis familiaris <400> 1594

Page 1791

Asp 1 Pro His Phe Pro 5 Ala Ser 069269_0225_SL.TXT Met Tyr Phe Phe Leu Asn 10 His Phe 15 Ser Leu Leu Asp Leu Cys Tyr Ser Leu Val Thr Ile Pro Lys Met Leu Glu 20 25 30 Lys Leu Leu Phe Gln Arg Lys Ser Ile Ser Val Glu Ala Asp Ser Gly 35 40 45 Leu Cys Met Cys Val Cys Cys Thr Ala Gly Ile Glu Ala Phe Leu Leu 50 55 60

<210> 1595 <211> 939 <212> DNA <213> Canis familiaris <400> 1595

atggacttgg ggaaccacag caccatcacg gagtttatcc tccttgggct ctctgctgac 60 cctcacatcc aggttgcact ctttgttctc ttcctgggga tttacctcct gactgtgatg 120 gggaacctga ttatgctgct ggtgatcagg actgattccc acctccatac acccatgtac 180 ttcttcctga gtcacctctc ttttgttgat atctgcttct cttcggtcac tgtgcccaag 240 atgctggaga accttctttc tcaaaagaaa accatctcag tagagtgctg cctcactcaa 300 gtcttcttcg tgtttgttgc tgcaggaact gaagcctgtc tgctctcagt gatggcctat 360 gaccgctatg ctgccatctg ccacccactg ctctatggac agatcatgaa taaacagctg 420 tatatgcagc ttgtatgggg atcatgggga ctgagctttc tggatgcact catcaacatc 480 tttctagcta tgaagatggt cttctgcaaa gcccaaatca tcccccacta cagctgtgaa 540 atgccctctc tcctctcatt gtcctgttct gatacctcca aaaacctcat tgccttgctc 600 tgctccactc ttctgcatgg gctgggaacc ttccttttgg tcttcttatc ctatgcccgt 660 attattgcca ctatcctgag catcagctcc acctcaggca gaagcaaggc cttctccacc 720 tgctcctcac acctcactgc agtgactctt tattatggct caggtttgct ccgccatctc 780 atgccaaatt caggatcccc cctcgagttg atcttttctg tacagtatac tgtagtcact 840 cctgtgctga atcctctcat ctacagcctg aagaacaagg aggtgaaggc agctctgaca 900

Page 1792

939

069269_0225_SL.TXT cgaactatgg aaaagtattt gcaacatatc aggtgctga <210> 1596 <211> 312 <212> PRT <213> Canis familiaris <400> 1596

Met 1 Asp Leu Gly Asn 5 His Ser Thr Ile Thr Glu Phe Ile Leu Leu Gly 10 15 Leu Ser Ala Asp Pro His Ile Gln Val Ala Leu Phe Val Leu Phe Leu 20 25 30 Gly Ile Tyr Leu Leu Thr Val Met Gly Asn Leu Ile Met Leu Leu Val 35 40 45 Ile Arg Thr Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Ile Cys Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Asn Leu Leu Ser Gln Lys Lys Thr Ile Ser Val Glu Cys 85 90 95 Cys Leu Thr Gln Val Phe Phe Val Phe Val Ala Ala Gly Thr Glu Ala 100 105 110 Cys Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Gly Gln Ile Met Asn Lys Gln Leu Tyr Met Gln Leu 130 135 140 Val Trp Gly Ser Trp Gly Leu Ser Phe Leu Asp Ala Leu Ile Asn Ile 145 150 155 160 Phe Leu Ala Met Lys Met Val Phe Cys Lys Ala Gln Ile Ile Pro His 165 170 175

Page 1793

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Tyr Ser Cys Glu 180 Met Pro Ser Lys Asn 195 Leu Ile Ala Gly Thr 210 Phe Leu Leu Val Ile 225 Leu Ser Ile Ser Ser 230 Cys Ser Ser His Leu 245 Thr Leu Arg His Leu 260 Met Pro Ser Val Gln 275 Tyr Thr Val Ser Leu 290 Lys Asn Lys Glu Lys 305 Tyr Leu Gln His Ile 310

Ser Leu Leu 185 Ser Leu Leu Leu 200 Cys Ser Thr Phe 215 Leu Ser Tyr Ala Thr Ser Gly Arg Ser 235 Ala Val Thr Leu 250 Tyr Asn Ser Gly 265 Ser Pro Val Thr 280 Pro Val Leu Val 295 Lys Ala Ala Leu Arg Cys

Ser Cys Ser 190 Asp Thr Leu Leu 205 His Gly Leu Arg 220 Ile Ile Ala Thr Lys Ala Phe Ser Thr 240 Tyr Gly Ser Gly 255 Leu Leu Glu Leu 270 Ile Phe Asn Pro 285 Leu Ile Tyr Thr 300 Arg Thr Met Glu

<210> 1597 <211> 906 <212> DNA <213> Canis familiaris <400> 1597 atgggcttgt ggaaccacag cccccatgcc caggctgcac ggggaacctg ctgctgctga ctttttcctt gtcatctctc atgctgaaag acctcctagc aaccatcacc caattccttc tctttgtgct gttcctgaac tggtgatcag agctgactct tttcctgggc ttttgtttat agagataaaa accatctcag tccttgggct atctactgac atttacctgc tgaccatcat cacctccacg tgcccgtgta cttcagttat tgtgcctaag taaggggctg cctggctcaa

120

180

240

300

Page 1794

069269_0225_SL.TXT

ggtttctttg tgtttatccc tgcaggaact gagggctttc tactctcagt gatggcctat 360 gaccactttg ctgacatccg ccatcctctg ctctatggac agatgatgag gaaacagctg 420 tgtgtacagc ttgtgtgggt ctcatgggtc gtgggtggtt tgaatacgct catcaacatc 480 ctccgagcta cccacttgga cttctgtgag agccatacca ccagccacta cagctatgag 540 gtgccctctc tcttcccttt gtcttgctct gatgtcttca ccaacctcat agtgctgttc 600 tgctccactc tgcttcatgg ggttgggacc ttcttcccaa tcatttcatc ctatgcctgc 660 attgtctcca ccatcctgag catcagctcc tcctcaggca gaagcaaagc cttctccacc 720 tgcccctctc acctcattgt ggtgagcttc ttctatggat ctgcttttct cagctatctc 780 atgccaaatt ctggataccc cctagagttg atctctatac agtatggtgt ggtcattccc 840 atgctgaatc ctctcatcta cagcctgaag aacaaggagg tgaaggcagc tgtgagaagg 900

aaattg 906 <210> 1598 <211> 222 <212> PRT <213> Canis familiaris

<400> 1598 Leu Leu 5 Ala Glu Ile Lys Thr Ile Ser Val Arg Gly Met Leu 1 Lys Asp 10 15 Cys Leu Ala Gln Gly Phe Phe Val Phe Ile Pro Ala Gly Thr Glu Gly 20 25 30 Phe Leu Leu Ser Val Met Ala Tyr Asp His Phe Ala Asp Ile Arg His 35 40 45 Pro Leu Leu Tyr Gly Gln Met Met Arg Lys Gln Leu Cys Val Gln Leu 50 55 60 Val Trp Val Ser Trp Val Val Gly Gly Leu Asn Thr Leu Ile Asn Ile 65 70 75 80 Leu Arg Ala Thr His Leu Asp Phe Cys Glu Ser His Thr Thr Ser His 85 90 95

Page 1795

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Tyr Ser Tyr Glu 100 Val Pro Ser Leu Phe Thr Asn 115 Leu Ile Val Leu Phe 120 Gly Thr 130 Phe Phe Pro Ile Ile 135 Ser Ile 145 Leu Ser Ile Ser Ser 150 Ser Ser Cys Pro Ser His Leu 165 Ile Val Val Leu Ser Tyr Leu 180 Met Pro Asn Ser Ile Gln Tyr 195 Gly Val Val Ile Pro 200 Leu Lys 210 Asn Lys Glu Val Lys 215 Ala

Phe Pro Leu Ser Cys Ser Asp Val 105 110 Cys Ser Thr Leu Leu 125 His Gly Val Ser Tyr Ala Cys 140 Ile Val Ser Thr Gly Arg Ser 155 Lys Ala Phe Ser Thr 160 Ser Phe 170 Phe Tyr Gly Ser Ala 175 Phe Gly 185 Tyr Pro Leu Glu Leu 190 Ile Ser Met Leu Asn Pro Leu 205 Ile Tyr Ser Ala Val Arg Arg 220 Lys Leu

<210> 1599 <211> 918 <212> DNA <213> Canis familiaris <400> 1599 atgagaaacc acagtgttgt ttctgagttc atccaggctc tgctctttat gctgttcctt ctgctactgc tgctggtgat tagagctgat ctgggacagt tgtccttcct ggatctctgc gagaaccttc tgtctgagaa gaaaaccatc tttgtgtttg ccactggggg cactgaatcc attctccttg ggctgtctgc tgacccccag gttatttacc tcctgaccct gatggggaac tctcaccttc acagccccat gtacttcttc cactcctctg tcactgtgcc caagcttttg tcagtagagg gctgcctcgc tcaggtcttc tgcctacttg ctgtcatggc ctatgaccgc

120

180

240

300

360

Page 1796

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tatgttgcca tcagctcccc tctgctctat ggccagatga tgaacagacc actgtgtatg 420 gggctggttt ggggctcatg gagcttagct tttctggatg ctcttatcaa tatccttgta 480 gctctcaatt tagacttctg tgaggctcag aatatacacc acttcagctg tgagctgcca 540 tctctctacc ctttgtcttg ctctgatgtg tctgcaagtt ttactgccct gctctgctcc 600 agcctcctgc atttctttgg aaatttcctc ctgatatttt tctcctatgt tcgcatttta 660 tccaccatcc tgagcatcag ttctaccaca ggcagaagca aggccttctc cacctgctcc 720 tcccacctca ctgcagtgat cttcttttat ggctcagggt tactccgtta tctcatgcca 780 aattcaggat ccactcaaga gttaatcttt tccttgcagt atagcgtggt cactcctatg 840 ctgaatcctc tcatctatag cctgaagaac aaagaggtga aggcagctgt gagaagaatt 900 ttgagaaaat gtgtctag 918 <210> 1600 <211> 305 <212> PRT <213> Canis familiaris <400> 1600 Met Arg Asn His Ser Val Val Ser Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15 Ala Asp Pro Gln Ile Gln Ala Leu Leu Phe Met Leu Phe Leu Val Ile 20 25 30 Tyr Leu Leu Thr Leu Met Gly Asn Leu Leu Leu Leu Leu Val Ile Arg 35 40 45 Ala Asp Ser His Leu His Ser Pro Met Tyr Phe Phe Leu Gly Gln Leu 50 55 60 Ser Phe Leu Asp Leu Cys His Ser Ser Val Thr Val Pro Lys Leu Leu 65 70 75 80 Glu Asn Leu Leu Ser Glu Lys Lys Thr Ile Ser Val Glu Gly Cys Leu 85 90 95 Ala Gln Val Phe Phe Val Phe Ala Thr Gly Gly Thr Glu Ser Cys Leu

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100

069269_0225_SL.TXT 105 110

Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser Ser Pro Leu 115 120 125 Leu Tyr Gly Gln Met Met Asn Arg Pro Leu Cys Met Gly Leu Val Trp 130 135 140 Gly Ser Trp Ser Leu Ala Phe Leu Asp Ala Leu Ile Asn Ile Leu Val 145 150 155 160 Ala Leu Asn Leu Asp Phe Cys Glu Ala Gln Asn Ile His His Phe Ser 165 170 175 Cys Glu Leu Pro Ser Leu Tyr Pro Leu Ser Cys Ser Asp Val Ser Ala 180 185 190 Ser Phe Thr Ala Leu Leu Cys Ser Ser Leu Leu His Phe Phe Gly Asn 195 200 205 Phe Leu Leu Ile Phe Phe Ser Tyr Val Arg Ile Leu Ser Thr Ile Leu 210 215 220 Ser Ile Ser Ser Thr Thr Gly Arg Ser Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Leu Thr Ala Val Ile Phe Phe Tyr Gly Ser Gly Leu Leu Arg 245 250 255 Tyr Leu Met Pro Asn Ser Gly Ser Thr Gln Glu Leu Ile Phe Ser Leu 260 265 270 Gln Tyr Ser Val Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu 275 280 285 Lys Asn Lys Glu Val Lys Ala Ala Val Arg Arg Ile Leu Arg Lys Cys 290 295 300

Val

Page 1798

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305 <210> 1601 <211> 936 <212> DNA <213> Canis familiaris <400> 1601

atggcaatga aaaactacag tgctatcagt gagttcattc ttcttggact atctattgac 60 cccagtattc aggtaatact ctttgtgcta ttccttctga tttatctctt cactctgatg 120 ggaaatttct tgatgctctt ggtgattagg gctgattctc acctccacat acccatgtac 180 ttctttttgc aacaactctc cttcctggac ctctgccact catctgtcac agtccccaag 240 atgctggaga atctactttc tgagagtaaa actatctttg tagaaagctg cctagctcag 300 gccttctttg tgtttgccac agggggcact gaggcctgtc tgctggctgt gatggcctat 360 gaccgctgta tagccatcac ctcccctctg ctctatggcc aggtgatgaa caaccaactc 420 tgtgttggga tggtgtggag ttcctggggc ctggcctttg ctgatgctct catcaatatc 480 ctcttggctg tcaatttaga ctattgtgag gaccagacta ttccccattt cagctgtgag 540 ctgtcttctc tcttccctct gtcttgctct gatacctcca ccaatttcac acttctgctc 600 tgctcctctt tcctgcattt ctttggaacc ttcctaatga ttgttttgtc ctatgcccgc 660 attgtcttca ccatcctgag catcagctct acctcaggca gaggcaaggc tttctccacc 720 tgctcctccc accttactac tgtgatcttg ttctatggct caggtttcct cagctatctc 780 ttgccaactt caggctcccc tctggagatg atgttctcct tgcaatatag tgtcattact 840 cccatgctga acccgctcat ttacagcttg cagaacaagg aggtgaaggc agctatggga 900 agaatcttca gaaaatattt ctattcttta atgtag 936

<210> 1602 <211> 311 <212> PRT <213> Canis familiaris <400> 1602

Met Ala Met Lys Asn Tyr Ser Ala Ile Ser Glu Phe Ile Leu Leu Gly 1 5 10 15

Page 1799

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Leu Ser Ile Asp 20 Pro Ser Ile Gln Val Ile Leu Phe Val Leu Phe Leu 25 30 Leu Ile Tyr Leu Phe Thr Leu Met Gly Asn Phe Leu Met Leu Leu Val 35 40 45 Ile Arg Ala Asp Ser His Leu His Ile Pro Met Tyr Phe Phe Leu Gln 50 55 60 Gln Leu Ser Phe Leu Asp Leu Cys His Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Asn Leu Leu Ser Glu Ser Lys Thr Ile Phe Val Glu Ser 85 90 95 Cys Leu Ala Gln Ala Phe Phe Val Phe Ala Thr Gly Gly Thr Glu Ala 100 105 110 Cys Leu Leu Ala Val Met Ala Tyr Asp Arg Cys Ile Ala Ile Thr Ser 115 120 125 Pro Leu Leu Tyr Gly Gln Val Met Asn Asn Gln Leu Cys Val Gly Met 130 135 140 Val Trp Ser Ser Trp Gly Leu Ala Phe Ala Asp Ala Leu Ile Asn Ile 145 150 155 160 Leu Leu Ala Val Asn Leu Asp Tyr Cys Glu Asp Gln Thr Ile Pro His 165 170 175 Phe Ser Cys Glu Leu Ser Ser Leu Phe Pro Leu Ser Cys Ser Asp Thr 180 185 190 Ser Thr Asn Phe Thr Leu Leu Leu Cys Ser Ser Phe Leu His Phe Phe 195 200 205 Gly Thr Phe Leu Met Ile Val Leu Ser Tyr Ala Arg Ile Val Phe Thr 210 215 220

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069269_0225_SL.TXT

Ile 225 Leu Ser Ile Ser Ser Thr Ser Gly Arg Gly Lys Ala Phe Ser Thr 230 235 240 Cys Ser Ser His Leu Thr Thr Val Ile Leu Phe Tyr Gly Ser Gly Phe 245 250 255 Leu Ser Tyr Leu Leu Pro Thr Ser Gly Ser Pro Leu Glu Met Met Phe 260 265 270 Ser Leu Gln Tyr Ser Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Gln Asn Lys Glu Val Lys Ala Ala Met Gly Arg Ile Phe Arg 290 295 300 Lys Tyr Phe Tyr Ser Leu Met 305 310

<210> 1603 <211> 738 <212> DNA <213> Canis familiaris <400> 1603

atcactatgg gaaaccatag catgttcagt gagtccatcc tccttaggtt gtctgctgac 60 cctcagacct ggattctgct ctccatgttg tttctggtgc tttacctcct cactctgatg 120 ggaaacctgg tgatgctgct ggtgatgagg gctaattctc accttccctg tacttctcct 180 atgcccatgt acttcttttt gagacaactc cccttcctgg acctctgcca ctcatctatc 240 acagtcccca agatgatgga gactatccta tcttctgaaa gcacagtcat ctttgtagag 300 agctgtctgg ctcaagcctt ctttgtgttt gccacagggg gcactgaggc ctttctgcag 360 gctgtggtgg cctatgacca ctttgtagcc atcacctccc ctctgctcta gggccaggtg 420 atgaacaacc agctctgtgt tgggatggtg tggagttcct ggggcctggc ctttgctgat 480 gctctcatca atatcctctt ggttgtcaat ttagactatt gtgaggacca gactattccc 540 catttcagct gtgagcggtc ttctctcttc cctttgtctt gctctgatac ctccaccaat 600 ttcgcactcc tgctctgctc ctctgtcttg catttctttg gaaccttcct aatgattgtt 660

Page 1801

720

738

069269_0225_SL.TXT tcttcccatg cctgcattgt ttccaccatc ctcagcatca gctccatctc ttgtaggtgt gaggcctttt ttacttgt <210> 1604 <211> 136 <212> PRT <213> Canis familiaris <400> 1604

Ile Thr 1 Met Gly Asn 5 His Ser Met Phe Ser Glu Ser Ile Leu 10 Leu 15 Arg Leu Ser Ala Asp Pro Gln Thr Trp Ile Leu Leu Ser Met Leu Phe Leu 20 25 30 Val Leu Tyr Leu Leu Thr Leu Met Gly Asn Leu Val Met Leu Leu Val 35 40 45 Met Arg Ala Asn Ser His Leu Pro Cys Thr Ser Pro Met Pro Met Tyr 50 55 60 Phe Phe Leu Arg Gln Leu Pro Phe Leu Asp Leu Cys His Ser Ser Ile 65 70 75 80 Thr Val Pro Lys Met Met Glu Thr Ile Leu Ser Ser Glu Ser Thr Val 85 90 95 Ile Phe Val Glu Ser Cys Leu Ala Gln Ala Phe Phe Val Phe Ala Thr 100 105 110 Gly Gly Thr Glu Ala Phe Leu Gln Ala Val Val Ala Tyr Asp His Phe 115 120 125 Val Ala Ile Thr Ser Pro Leu Leu 130 135

<210> 1605 <211> 822 <212> DNA <213> Canis familiaris

Page 1802

069269_0225_SL.TXT <400> 1605

ctggtgattt acctcttgac cttgatgggg aatctgatga tgatcctggt gatcagaaat 60 gattctcacc ttaaaacacc catgtacttc ttcctaggtc acctgtcatt tctagatctc 120 tgcctttctt cagtaacgat gcctaagatg ctgcagaatt tattagctca aaagaaaact 180 atttctacat ggggctgtgt gacccagagt ttctttctca tattttctgg gagcacagag 240 gcctgcttac tgtcagccat ggcctatgac cgctatgctg ccatctgcca ccctctccta 300 tatagtgtgg ttatgaatag gcctctctgt gttgggatga taattgcagc atgggcagtg 360 gggttcctaa actccttgcc aaatagtctt ttcacctaca acttacattt ctgtggcccc 420 aatgtcatcc ctcacttttg ctgtgagctt ccttctctct tccctctgtc ctgcactgac 480 gctactgcca atgaggtcct tcttgctggg tcatgtgcat tgttgggatt tgtgacactt 540 cccctcatcc tcttctctta ttctagaatc atctctgcca tcctagtcat ccgttcttct 600 gggggtcaag gcaaagcctt ctctacctgt tcttcccacc tcactgtggt gcttttgtac 660 tatggcacag ctttattcag gtacatgact cccctctcag gctctaagtt ggaacaagtg 720 gtttccattc agtacagtgt gatcacatct ttgctgaacc ccctcatcta tagcctcaag 780 aaccaggagg tgaaggcagc tctgcataaa atgttgaagc aa 822

<210> 1606 <211> 274 <212> PRT <213> Canis familiaris <400> 1606

Leu Val Ile Tyr Leu Leu Thr Leu Met Gly Asn Leu Met Met Ile Leu 1 5 10 15 Val Ile Arg Asn Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu 20 25 30 Gly His Leu Ser Phe Leu Asp Leu Cys Leu Ser Ser Val Thr Met Pro 35 40 45 Lys Met Leu Gln Asn Leu Leu Ala Gln Lys Lys Thr Ile Ser Thr Trp 50 55 60

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Gly 65 Cys Val Thr Gln Ser Phe Phe Leu Ile Phe Ser Gly Ser Thr Glu 70 75 80 Ala Cys Leu Leu Ser Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys 85 90 95 His Pro Leu Leu Tyr Ser Val Val Met Asn Arg Pro Leu Cys Val Gly 100 105 110 Met Ile Ile Ala Ala Trp Ala Val Gly Phe Leu Asn Ser Leu Pro Asn 115 120 125 Ser Leu Phe Thr Tyr Asn Leu His Phe Cys Gly Pro Asn Val Ile Pro 130 135 140 His Phe Cys Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Thr Asp 145 150 155 160 Ala Thr Ala Asn Glu Val Leu Leu Ala Gly Ser Cys Ala Leu Leu Gly 165 170 175 Phe Val Thr Leu Pro Leu Ile Leu Phe Ser Tyr Ser Arg Ile Ile Ser 180 185 190 Ala Ile Leu Val Ile Arg Ser Ser Gly Gly Gln Gly Lys Ala Phe Ser 195 200 205 Thr Cys Ser Ser His Leu Thr Val Val Leu Leu Tyr Tyr Gly Thr Ala 210 215 220 Leu Phe Arg Tyr Met Thr Pro Leu Ser Gly Ser Lys Leu Glu Gln Val 225 230 235 240 Val Ser Ile Gln Tyr Ser Val Ile Thr Ser Leu Leu Asn Pro Leu Ile 245 250 255 Tyr Ser Leu Lys Asn Gln Glu Val Lys Ala Ala Leu His Lys Met Leu 260 265 270

Page 1804

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Lys Gln <210> 1607 <211> 912 <212> DNA <213> Canis familiaris <400> 1607 atgaacaact tcactttctt cactgagttc atcctccttg ggctgtctgc tgactgccac 60 gtccagactc tgctctttgt gctgtttctg ggaatttacc tcctgactct gatggggaat 120 ctggtgatga tcctcgtgat caggggggat tctcacctcc atatccccat gtattttttc 180 cttggacacc tgtccttcct agatatctgc ttctcctcag ttactatgcc caaaatgctg 240 cagaacttcc tgtctgagaa gaaaagcatc tcggtctggg gctgcatcac ccagagtttc 300 ttttttcttc tctctgggtg tgctgaagcc agtcttctct ctgccatggc ctatgaccgc 360 tatgctgctg tctgctaccc tctgctctat accatggtca tgaacagatc tctttgcata 420 gtaatggtta gtgcagcatg ggtgatgggg tttctgaact cactagtgaa taatcttttc 480 atccacaagt tacatttttg tgggtccaat gtcatctccc acttctgctg cgagctaccc 540 tcactcttcc ctctgtcatg tactgatccc actgccaaca aattccttct gtcagggtcc 600 agtgcatttc tgggactgct gacacttccc ctgatcctct tctcttactc cagaatcatt 660 tctgccattc tgaacatccg ctcctctgag ggccaagcca aagccttctc cacctgctcc 720 tcccacctca ccgtggtact cttgttctat gggacagctc tattcaggta catcagccct 780 gcctcaggct cggtgttgga gcgagtggtc tccattcagt acagtgtgat cacatctttg 840 gtgaaccccc tcatctacag tctcaagaac caagaggtga aggcagctct gcagaggctg 900 ctgaggcaat aa 912 <210> 1608 <211> 303 <212> PRT <213> Canis familiaris <400> 1608

Met Asn Asn Phe Thr Phe Phe Thr Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15

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Ala Asp Cys His 20 Val Gln Thr Leu Leu Phe Val Leu Phe Leu Gly Ile 25 30 Tyr Leu Leu Thr Leu Met Gly Asn Leu Val Met Ile Leu Val Ile Arg 35 40 45 Gly Asp Ser His Leu His Ile Pro Met Tyr Phe Phe Leu Gly His Leu 50 55 60 Ser Phe Leu Asp Ile Cys Phe Ser Ser Val Thr Met Pro Lys Met Leu 65 70 75 80 Gln Asn Phe Leu Ser Glu Lys Lys Ser Ile Ser Val Trp Gly Cys Ile 85 90 95 Thr Gln Ser Phe Phe Phe Leu Leu Ser Gly Cys Ala Glu Ala Ser Leu 100 105 110 Leu Ser Ala Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Tyr Pro Leu 115 120 125 Leu Tyr Thr Met Val Met Asn Arg Ser Leu Cys Ile Val Met Val Ser 130 135 140 Ala Ala Trp Val Met Gly Phe Leu Asn Ser Leu Val Asn Asn Leu Phe 145 150 155 160 Ile His Lys Leu His Phe Cys Gly Ser Asn Val Ile Ser His Phe Cys 165 170 175 Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Thr Asp Pro Thr Ala 180 185 190 Asn Lys Phe Leu Leu Ser Gly Ser Ser Ala Phe Leu Gly Leu Leu Thr 195 200 205 Leu Pro Leu Ile Leu Phe Ser Tyr Ser Arg Ile Ile Ser Ala Ile Leu 210 215 220

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Asn Ile 225 Arg Ser Ser Glu Gly 230 Gln Ala Lys Ala Phe Ser Thr Cys Ser 235 240 Ser His Leu Thr Val Val Leu Leu Phe Tyr Gly Thr Ala Leu Phe Arg 245 250 255 Tyr Ile Ser Pro Ala Ser Gly Ser Val Leu Glu Arg Val Val Ser Ile 260 265 270 Gln Tyr Ser Val Ile Thr Ser Leu Val Asn Pro Leu Ile Tyr Ser Leu 275 280 285 Lys Asn Gln Glu Val Lys Ala Ala Leu Gln Arg Leu Leu Arg Gln 290 295 300

<210> 1609 <211> 912 <212> DNA <213> Canis familiaris <400> 1609 gaaaaccaga ccacctggct gatcctggtt ggctttgggg atctgcaaca cctaggcttc ctccccttca ccttcttttt ggccatttat gtggtaacag ttgggggcaa cgccctcatc gtgctggctg tggcctccag tcggacactc cacacaccca tgtatttctt cctctgccac ttctccttgc tggagattgg ttatacctcc aacatcatgc ctcagctgct gtggagcttt ctggaaggga gggaagccat ctcactggtc agctgtctgg tccagttcta cgtgtttgcc tccctggctg ctgttgagtg cctcctgcta tctgctatgt cctatgaccg ttacttggcc atctgccacc ctcttcgcta ccctgccctg atgagcacct ggttgtgtgg ctgcctcgct gctggagcct gggtcagtgg cttttctttc tctgccttca ctctggccct ggcagcccct cttcccctct gccctggcag cagggagatc gaccactact tctgtgactt tgctccagtt gtagggctgt tctgtgggga tgtgggggtc atgtggggag ctggggtgag catctcaggc tttctgacat tggccccctt cctgttgatt gtggcacccc ttcctgttga ttgtggcacc tatgccttca tcttgaggac tgtgctgcaa ataccttcag gccatggtag gcagaaagcc ttctccacct gttcctccca cctcagcgtg gtcggggtgt tttatggcac cctcattgtg

120

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Page 1807

069269_0225_SL.TXT gtctatgtag ccccaacaga ccacatggcc cccttgctcc gaaaggcctt ctctgtcctc tatactgtat tcactcctat ggtcaacccc atcatttaca gcctcaagaa ccaagaggta aagggggccc tt

840

900

912 <210> 1610 <211> 304 <212> PRT <213> Canis familiaris

<400> 1610 Trp Leu Ile Leu Val Gly Phe Gly Asp Leu Gln Glu Asn 1 Gln Thr Thr 5 10 15 His Leu Gly Phe Leu Pro Phe Thr Phe Phe Leu Ala Ile Tyr Val Val 20 25 30 Thr Val Gly Gly Asn Ala Leu Ile Val Leu Ala Val Ala Ser Ser Arg 35 40 45 Thr Leu His Thr Pro Met Tyr Phe Phe Leu Cys His Phe Ser Leu Leu 50 55 60 Glu Ile Gly Tyr Thr Ser Asn Ile Met Pro Gln Leu Leu Trp Ser Phe 65 70 75 80 Leu Glu Gly Arg Glu Ala Ile Ser Leu Val Ser Cys Leu Val Gln Phe 85 90 95 Tyr Val Phe Ala Ser Leu Ala Ala Val Glu Cys Leu Leu Leu Ser Ala 100 105 110 Met Ser Tyr Asp Arg Tyr Leu Ala Ile Cys His Pro Leu Arg Tyr Pro 115 120 125 Ala Leu Met Ser Thr Trp Leu Cys Gly Cys Leu Ala Ala Gly Ala Trp 130 135 140 Val Ser Gly Phe Ser Phe Ser Ala Phe Thr Leu Ala Leu Ala Ala Pro 145 150 155 160

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Leu Pro Leu Cys Pro 165 Gly Ser Arg Phe Ala Pro Val 180 Val Gly Leu Phe Gly Ala Gly 195 Val Ser Ile Ser Gly 200 Leu Ile 210 Val Ala Pro Leu Pro 215 Val Leu 225 Arg Thr Val Leu Gln 230 Ile Pro Phe Ser Thr Cys Ser 245 Ser His Leu Thr Leu Ile Val 260 Val Tyr Val Ala Leu Arg Lys 275 Ala Phe Ser Val Leu 280 Asn Pro 290 Ile Ile Tyr Ser Leu 295 Lys

Glu Ile 170 Asp His Tyr Phe Cys 175 Asp Cys 185 Gly Asp Val Gly Val 190 Met Trp Phe Leu Thr Leu Ala 205 Pro Phe Leu Asp Cys Gly Thr 220 Tyr Ala Phe Ile Ser Gly His 235 Gly Arg Gln Lys Ala 240 Ser Val 250 Val Gly Val Phe Tyr 255 Gly Pro 265 Thr Asp His Met Ala 270 Pro Leu Tyr Thr Val Phe Thr 285 Pro Met Val Asn Gln Glu Val 300 Lys Gly Ala Leu

<210> 1611 <211> 930 <212> DNA <213> Canis familiaris <400> 1611 atgaaaaacg tcagtataat tactgaattt atccagacta tgctctttgt gctgttcctg ctggtgatga tcctggtgat cagggttgat ctcggacact tatccttcct ggatctcagt gtccttctgg gattgtctag tgatccccag gggatttacc ttctgacttt gatgggaaat tctcatctcc aaacacccat gtacttcttc ttctcctcag tcactgtgcc caaaatgcta

120

180

240

Page 1809

069269_0225_SL.TXT cagaacttct tatctcagaa gaaaagcatc tcggtgtggg gttgcatcac tcagagtttc tttttcactc tctctggagg aacagaagct tgtctgctct ctgccatggc ctatgaccgc tatgctgcca tctgctaccc tctggtctac accatggtca taaacaggcc tctctgtatt gtgactgtga gtatagcttg gacagtggga tttctgattt ccttgatgaa tattcttttc atctacaagt tacatttctg tgggtccaac attatccccc atttcagctg tgagctacct ccgctctttc ctctgtcctg tacagatccc attgtcaatg agattcttct agcagtgtca tgtgcgtttc tgggactgct gacacttccc ctaatcctct tctcttactc cagaatcatt tctgccattc tgaacatccg ctcctctgag ggccaagcca aagccttctc cacctgctcc tcccacctca ccgtggtact cttgttctat gggacagctc tattcaggta catcagccct gcctcaggct cagtgttgga gcgagtggtc tccattcagt acagtgtgat cacatctttg gtgaaccccc tcatctacag tctcaagaac caagaggtga aggcagctct gcagaggatg ctaaagcaac aaaagtgtgc cctggggtag <210> 1612 <211> 309 <212> PRT <213> Canis familiaris <400> 1612

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930

Met 1 Lys Asn Val Ser Ile 5 Ile Thr Glu Phe Val Leu Leu Gly Leu Ser 10 15 Ser Asp Pro Gln Ile Gln Thr Met Leu Phe Val Leu Phe Leu Gly Ile 20 25 30 Tyr Leu Leu Thr Leu Met Gly Asn Leu Val Met Ile Leu Val Ile Arg 35 40 45 Val Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Gly His Leu 50 55 60 Ser Phe Leu Asp Leu Ser Phe Ser Ser Val Thr Val Pro Lys Met Leu 65 70 75 80 Gln Asn Phe Leu Ser Gln Lys Lys Ser Ile Ser Val Trp Gly Cys Ile Page 1810

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85 90 95

Thr Gln Ser Phe Phe Phe Thr Leu Ser Gly Gly Thr Glu Ala Cys Leu 100 105 110 Leu Ser Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Tyr Pro Leu 115 120 125 Val Tyr Thr Met Val Ile Asn Arg Pro Leu Cys Ile Val Thr Val Ser 130 135 140 Ile Ala Trp Thr Val Gly Phe Leu Ile Ser Leu Met Asn Ile Leu Phe 145 150 155 160 Ile Tyr Lys Leu His Phe Cys Gly Ser Asn Ile Ile Pro His Phe Ser 165 170 175 Cys Glu Leu Pro Pro Leu Phe Pro Leu Ser Cys Thr Asp Pro Ile Val 180 185 190 Asn Glu Ile Leu Leu Ala Val Ser Cys Ala Phe Leu Gly Leu Leu Thr 195 200 205 Leu Pro Leu Ile Leu Phe Ser Tyr Ser Arg Ile Ile Ser Ala Ile Leu 210 215 220 Asn Ile Arg Ser Ser Glu Gly Gln Ala Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Leu Thr Val Val Leu Leu Phe Tyr Gly Thr Ala Leu Phe Arg 245 250 255 Tyr Ile Ser Pro Ala Ser Gly Ser Val Leu Glu Arg Val Val Ser Ile 260 265 270 Gln Tyr Ser Val Ile Thr Ser Leu Val Asn Pro Leu Ile Tyr Ser Leu 275 280 285 Lys Asn Gln Glu Val Lys Ala Ala Leu Gln Arg Met Leu Lys Gln Gln

Page 1811

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290 295 300

Lys Cys Ala Leu Gly 305 <210> 1613 <211> 363 <212> DNA <213> Canis familiaris <400> 1613

cagagtttat cctcatgggc tttgagcaga gctcctcttc cactcaggca ctactctttg 60 ctccccatgt ccatgaatgg ccttatcatc ttcatcacct ggacagaccc caggctcaac 120 agccccatgt acttcttcct tggccacctg tccttcctgg atgtctgctt catcaccacc 180 actatcccac agatgctgat ccacctggtg atcaaggaat atctcctttg cctctgcttg 240 acccaaatgt atctggtttt tggtgtaggt gtggccaagt gcaccctctt ggcttttatg 300 gcctatgacg gttatgttgc tatctgccac ccactcagct atgcccagat catgagtcac 360

agg 363 <210> 1614 <211> 121 <212> PRT <213> Canis familiaris

<400> 1614 Gln Ser Leu Ser 1 Ser 5 Trp Ala Leu Ser Arg Ala Pro Leu Pro Leu Arg 10 15 His Tyr Ser Leu Leu Pro Met Ser Met Asn Gly Leu Ile Ile Phe Ile 20 25 30 Thr Trp Thr Asp Pro Arg Leu Asn Ser Pro Met Tyr Phe Phe Leu Gly 35 40 45 His Leu Ser Phe Leu Asp Val Cys Phe Ile Thr Thr Thr Ile Pro Gln 50 55 60 Met Leu Ile His Leu Val Ile Lys Glu Tyr Leu Leu Cys Leu Cys Leu 65 70 75 80

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Thr Gln Met Tyr Leu Val Phe Gly Val Gly Val Ala Lys Cys Thr Leu 85 90 95 Leu Ala Phe Met Ala Tyr Asp Gly Tyr Val Ala Ile Cys His Pro Leu 100 105 110 Ser Tyr Ala Gln Ile Met Ser His Arg 115 120

<210> 1615 <211> 1029 <212> DNA <213> Canis familiaris <400> 1615

ctgggtctct gggctcaagt gagtacctta cattccctac aaactatctc acctgtgctt 60 tcctgtcctc cctcctcaag caggtccaag acagtggacc taaggaatgg cagcacagtg 120 acagagttca tcctcgtggg ctttgagcag agctcctctt ccactcaggc attactcttt 180 gtcctcttcc tagccctcta cagccttgcc atggccatga atggcctcat catcttcatc 240 acctggacag accccaggct caacagcccc atgtacttct tccttggcca cctgtccttc 300 ctggatgtct gcttcatcac caccactatc ccgcagatgc tgatccactt ggtggtcaag 360 aaccacattg tctcttttgt ctcttgcttg acccagatgt acttggtctt ctgtgtgggt 420 gtggctgagt gcatcctctt ggcttttatg gcctatgacc gttatgttgc tatctgccac 480 ccactcagct atgcccagat catgagccgg caggtctgtg tgaagctggt gagtactgcc 540 tggctctttg ggctgatcaa tggcatcttt cttgagtata tgtcattccg gaatcccttc 600 tgtagagaca accacataga gaacttcttc tgtgaggccc ccatagtgat tgccctgtct 660 tgtggagacc cccaatttag tctgagaatg atctttgccg atgcaatcgt ggtgctactc 720 agccccatgg tgctcattgt catctcctat gcccgcatcc tggcctccat ccttggaaga 780 gcctcctcct caggtcgagg gaagaccttc tctacttgtg cctcccatct gactgtggtc 840 atctttttct acacctctgc catgttctct tatatgaacc ctcgcagcac acatggccct 900 gacaaagaca agcctttctc cctcctctac accatcatca cccccatgtg caaccccatc 960

Page 1813

1020

1029

069269_0225_SL.TXT atctatagtt ttcgaaacaa ggaaatgaag ggagccatgg tgagggccct tgggaggacc agcctggct <210> 1616 <211> 343 <212> PRT <213> Canis familiaris <400> 1616

Leu 1 Gly Leu Trp Ala 5 Gln Val Ser Thr Leu His Ser Leu Gln Thr Ile 10 15 Ser Pro Val Leu Ser Cys Pro Pro Ser Ser Ser Arg Ser Lys Thr Val 20 25 30 Asp Leu Arg Asn Gly Ser Thr Val Thr Glu Phe Ile Leu Val Gly Phe 35 40 45 Glu Gln Ser Ser Ser Ser Thr Gln Ala Leu Leu Phe Val Leu Phe Leu 50 55 60 Ala Leu Tyr Ser Leu Ala Met Ala Met Asn Gly Leu Ile Ile Phe Ile 65 70 75 80 Thr Trp Thr Asp Pro Arg Leu Asn Ser Pro Met Tyr Phe Phe Leu Gly 85 90 95 His Leu Ser Phe Leu Asp Val Cys Phe Ile Thr Thr Thr Ile Pro Gln 100 105 110 Met Leu Ile His Leu Val Val Lys Asn His Ile Val Ser Phe Val Ser 115 120 125 Cys Leu Thr Gln Met Tyr Leu Val Phe Cys Val Gly Val Ala Glu Cys 130 135 140 Ile Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 145 150 155 160 Pro Leu Ser Tyr Ala Gln Ile Met Ser Arg Gln Val Cys Val Lys Leu Page 1814

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165 170 175

Val Ser Thr Ala 180 Trp Leu Phe Gly Leu Ile Asn Gly Ile Phe Leu Glu 185 190 Tyr Met Ser Phe Arg Asn Pro Phe Cys Arg Asp Asn His Ile Glu Asn 195 200 205 Phe Phe Cys Glu Ala Pro Ile Val Ile Ala Leu Ser Cys Gly Asp Pro 210 215 220 Gln Phe Ser Leu Arg Met Ile Phe Ala Asp Ala Ile Val Val Leu Leu 225 230 235 240 Ser Pro Met Val Leu Ile Val Ile Ser Tyr Ala Arg Ile Leu Ala Ser 245 250 255 Ile Leu Gly Arg Ala Ser Ser Ser Gly Arg Gly Lys Thr Phe Ser Thr 260 265 270 Cys Ala Ser His Leu Thr Val Val Ile Phe Phe Tyr Thr Ser Ala Met 275 280 285 Phe Ser Tyr Met Asn Pro Arg Ser Thr His Gly Pro Asp Lys Asp Lys 290 295 300 Pro Phe Ser Leu Leu Tyr Thr Ile Ile Thr Pro Met Cys Asn Pro Ile 305 310 315 320 Ile Tyr Ser Phe Arg Asn Lys Glu Met Lys Gly Ala Met Val Arg Ala 325 330 335 Leu Gly Arg Thr Ser Leu Ala

340 <210> 1617 <211> 1047 <212> DNA <213> Canis familiaris

Page 1815

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<400> 1617 atgggtctct gggctcaagt gagtacctta cattccctac aaactatctc acctgtgctt 60 tcctgtcctc cctcctcaag caggtccaag acagtggacc taaggaatgg cagcacagta 120 acagagttca tcctcgtggg ctttgagcag agctcctctt ccactcgggc attactcttt 180 gctctcttcc tagccctcta cagccttgcc atggccatga atggcctcat catcttcatc 240 acctggacag accccaggct caacagcccc atgtacttct tccttggcca cctgtccttc 300 ctggatgtct gcttcatcac caccactatc ccgcagatgc tgatccactt ggtggtcaag 360 aaccacattg tctcttttgt ctcttgcttg acccagatgt acttggtctt ctgtgtgggt 420 gtggctgagt gcatcctctt ggcttttatg gcctatgacc gttatgttgc tatctgccac 480 ccactcagct atgcccagat catgagccag caggtctgtg tgaagctggt gagtactgcc 540 tggctctttg ggctgatcaa tggcatcttt cttgagtata tgtcattccg gaatcccttc 600 tgtagagaca accacataga gaacttcttc tgtgaggccc ccatagtgat tgccctgtct 660 tgtggagaca cccggtttag tctgaggatg atctttgtcg atgccatttt ggtgctgctc 720 agccccatgg tgctcattgt catctcctat gcccgcatcc tggcctccat ccttggcaga 780 gcctcctcct caggtcgagg gaagaccttc tctacttgtg cctcccatct gactgtggtc 840 ctccttctgt atacctctgc catgttctct tacatgaacc ctcgcagcac acatggccct 900 gacaaagaca agcctttctc cctcctctac accatcatca cccccatgtg caaccccatc 960 atctatagtt ttcgaaacaa agaaatgttg ggagccatgg tgagggccct tgggaggatc 1020 agcctggccc aggatgagtc tgtctag 1047

<210> 1618 <211> 348 <212> PRT <213> Canis familiaris <400> 1618

Met Gly Leu Trp Ala Gln Val Ser Thr Leu His Ser Leu Gln Thr Ile 1 5 10 15

Ser Pro Val Leu Ser Cys Pro Pro Ser Ser Ser Arg Ser Lys Thr Val 20 25 30

Page 1816

Asp Leu Arg 35 Asn Gly Ser Thr 069269_0225_SL.TXT Val Thr Glu Phe Ile Leu 40 45 Val Gly Phe Glu Gln Ser Ser Ser Ser Thr Arg Ala Leu Leu Phe Ala Leu Phe Leu 50 55 60 Ala Leu Tyr Ser Leu Ala Met Ala Met Asn Gly Leu Ile Ile Phe Ile 65 70 75 80 Thr Trp Thr Asp Pro Arg Leu Asn Ser Pro Met Tyr Phe Phe Leu Gly 85 90 95 His Leu Ser Phe Leu Asp Val Cys Phe Ile Thr Thr Thr Ile Pro Gln 100 105 110 Met Leu Ile His Leu Val Val Lys Asn His Ile Val Ser Phe Val Ser 115 120 125 Cys Leu Thr Gln Met Tyr Leu Val Phe Cys Val Gly Val Ala Glu Cys 130 135 140 Ile Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 145 150 155 160 Pro Leu Ser Tyr Ala Gln Ile Met Ser Gln Gln Val Cys Val Lys Leu 165 170 175 Val Ser Thr Ala Trp Leu Phe Gly Leu Ile Asn Gly Ile Phe Leu Glu 180 185 190 Tyr Met Ser Phe Arg Asn Pro Phe Cys Arg Asp Asn His Ile Glu Asn 195 200 205 Phe Phe Cys Glu Ala Pro Ile Val Ile Ala Leu Ser Cys Gly Asp Thr 210 215 220 Arg Phe Ser Leu Arg Met Ile Phe Val Asp Ala Ile Leu Val Leu Leu 225 230 235 240

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Ser Pro Met Val Leu Ile Val Ile Ser Tyr Ala Arg Ile Leu Ala Ser 245 250 255 Ile Leu Gly Arg Ala Ser Ser Ser Gly Arg Gly Lys Thr Phe Ser Thr 260 265 270 Cys Ala Ser His Leu Thr Val Val Leu Leu Leu Tyr Thr Ser Ala Met 275 280 285 Phe Ser Tyr Met Asn Pro Arg Ser Thr His Gly Pro Asp Lys Asp Lys 290 295 300 Pro Phe Ser Leu Leu Tyr Thr Ile Ile Thr Pro Met Cys Asn Pro Ile 305 310 315 320 Ile Tyr Ser Phe Arg Asn Lys Glu Met Leu Gly Ala Met Val Arg Ala 325 330 335 Leu Gly Arg Ile Ser Leu Ala Gln Asp Glu Ser Val

340 345 <210> 1619 <211> 1044 <212> DNA <213> Canis familiaris <400> 1619

ctgggtctct gggctcaagt gagtacctta cattccctac aaactatctc acctgtgctt 60 tcttgtcctc cctcctcaag caggtccaag acagtggacc taaggaatgg cagcacagtg 120 acagagttca tcctcgtggg ctttgagcag agctcctctt ccactcaggc attactcttt 180 gctctcttcc tagccctcta cagccttgcc atggccatga atggcctcat catcttcatc 240 acctggacag accccaggct caacagcccc atgtacttct tccttggcca cctgtccttc 300 ctggatgtct gcttcatcac caccactatc ccacagatgc tgatccacct ggtggtcaag 360 aaccacattg tctcctttgc ctcttgcttg acccagatgt atctggtttt tggtgtaggt 420 gttgctgagt gcatcctctt ggcctttatg gcctatgacc gttatgttgc tatctgccac 480 ccgctcagct atgcccagat catgagccgg caggtctgtg tgaagctggt gagtactgcc 540

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tggttctttg ggctgatcaa tgggattctg ctggattata tgacatttcg tggtcccttc 600 tgtagagaca accacataga gaacttcttc tgtgaggccc ccatagtgat tgccctgtct 660 tgtggagacc cccagtttag tctcaggaca atctttgctg atgccgtcgt ggtgctgctc 720 agccccatgg tgctcattgt catctcctat gcccgcatcc tggcctccat ccttggcaga 780 gcctcctcct caggtcgagg gaagaccttc tctacttgtg cctcccatct gactgtggtc 840 atctttttct acacctctgc catgttctct tacatgaacc ctcgcagcac acatggccct 900 gacaaagaca agcctttctc cctcctctac accatcatca cccccatgtg caaccccatc 960 atctatagtt ttcgaaacaa ggaaatgaaa ggagccatgg tgagggccct tgggaggacc 1020 agcctggcac aggcagagtc tgtc 1044

<210> 1620 <211> 348 <212> PRT <213> Canis familiaris

<400> 1620 Gln Val Ser Thr Leu His Ser Leu Gln Thr Ile Leu Gly 1 Leu Trp Ala 5 10 15 Ser Pro Val Leu Ser Cys Pro Pro Ser Ser Ser Arg Ser Lys Thr Val 20 25 30 Asp Leu Arg Asn Gly Ser Thr Val Thr Glu Phe Ile Leu Val Gly Phe 35 40 45 Glu Gln Ser Ser Ser Ser Thr Gln Ala Leu Leu Phe Ala Leu Phe Leu 50 55 60 Ala Leu Tyr Ser Leu Ala Met Ala Met Asn Gly Leu Ile Ile Phe Ile 65 70 75 80 Thr Trp Thr Asp Pro Arg Leu Asn Ser Pro Met Tyr Phe Phe Leu Gly 85 90 95 His Leu Ser Phe Leu Asp Val Cys Phe Ile Thr Thr Thr Ile Pro Gln 100 105 110

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Met Leu Ile 115 His Leu Val Val Lys Asn His Ile Val Ser Phe Ala Ser 120 125 Cys Leu Thr Gln Met Tyr Leu Val Phe Gly Val Gly Val Ala Glu Cys 130 135 140 Ile Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 145 150 155 160 Pro Leu Ser Tyr Ala Gln Ile Met Ser Arg Gln Val Cys Val Lys Leu 165 170 175 Val Ser Thr Ala Trp Phe Phe Gly Leu Ile Asn Gly Ile Leu Leu Asp 180 185 190 Tyr Met Thr Phe Arg Gly Pro Phe Cys Arg Asp Asn His Ile Glu Asn 195 200 205 Phe Phe Cys Glu Ala Pro Ile Val Ile Ala Leu Ser Cys Gly Asp Pro 210 215 220 Gln Phe Ser Leu Arg Thr Ile Phe Ala Asp Ala Val Val Val Leu Leu 225 230 235 240 Ser Pro Met Val Leu Ile Val Ile Ser Tyr Ala Arg Ile Leu Ala Ser 245 250 255 Ile Leu Gly Arg Ala Ser Ser Ser Gly Arg Gly Lys Thr Phe Ser Thr 260 265 270 Cys Ala Ser His Leu Thr Val Val Ile Phe Phe Tyr Thr Ser Ala Met 275 280 285 Phe Ser Tyr Met Asn Pro Arg Ser Thr His Gly Pro Asp Lys Asp Lys 290 295 300 Pro Phe Ser Leu Leu Tyr Thr Ile Ile Thr Pro Met Cys Asn Pro Ile 305 310 315 320

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Ile Tyr Ser Phe Arg Asn Lys Glu Met Lys Gly Ala Met Val Arg Ala 325 330 335

Leu Gly Arg Thr Ser Leu Ala Gln Ala Glu Ser Val 340 345 <210> 1621 <211> 780 <212> DNA <213> Canis familiaris <400> 1621

atggaagttg gcaacataac cacagtcaca tttgtcctcc taggactatc caacaatcct 60 cagatccagg ctctgctctt tgtgctcttc ctggggattt acctcctgac cattctgggg 120 aacctggcga tgctgctggt caccagggct gattctcacc tccacacacc catgtacttc 180 ttcctgagtc acctctcctt cttggatgct ttctattcct caatcattgt gcctaaattg 240 ctagagaacc tcctttccaa gtggaagact gtttcctctg ttgaatgttt cacccagatc 300 tccttggtca tattttctgg ggccactgaa acttgcctcc tttcagtcat ggcctatgac 360 cggttccagg ctgtgtgcca cccactgttg tatgtggtgg ctatgaacaa gaagctatgt 420 actggcctgg tggtagcatc ctgggccata ggagtaggga ctagcctggt taacagcatc 480 cttctggctc agcagcactt ctgtgggccc aatcttgtcc gtagttttgc ctgtgagctt 540 cccccagtgc tcctgctgac ctgttctgac ccctatgtta gtgttgcctc caatctgacc 600 accatggcag tcctgggcct tggtgccttt gtcctattgc tgggctccta cacccgtatc 660 atcatgacag ccctaggaat caactctgcc actggtcgga gaaagatctt ttccacctgc 720 tcttctcatc ttcttgtgat caccaacttt tatggttcag gagttatcag gtatgtcata 780

<210> 1622 <211> 260 <212> PRT <213> Canis familiaris <400> 1622

Met Glu Val Gly Asn Ile Thr Thr Val Thr Phe Val Leu Leu Gly Leu 1 5 10 15

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Ser Asn Asn Pro 20 Gln Ile Gln Ala Leu Leu Phe Val Leu Phe Leu Gly 25 30 Ile Tyr Leu Leu Thr Ile Leu Gly Asn Leu Ala Met Leu Leu Val Thr 35 40 45 Arg Ala Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ser Phe Leu Asp Ala Phe Tyr Ser Ser Ile Ile Val Pro Lys Leu 65 70 75 80 Leu Glu Asn Leu Leu Ser Lys Trp Lys Thr Val Ser Ser Val Glu Cys 85 90 95 Phe Thr Gln Ile Ser Leu Val Ile Phe Ser Gly Ala Thr Glu Thr Cys 100 105 110 Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Gln Ala Val Cys His Pro 115 120 125 Leu Leu Tyr Val Val Ala Met Asn Lys Lys Leu Cys Thr Gly Leu Val 130 135 140 Val Ala Ser Trp Ala Ile Gly Val Gly Thr Ser Leu Val Asn Ser Ile 145 150 155 160 Leu Leu Ala Gln Gln His Phe Cys Gly Pro Asn Leu Val Arg Ser Phe 165 170 175 Ala Cys Glu Leu Pro Pro Val Leu Leu Leu Thr Cys Ser Asp Pro Tyr 180 185 190 Val Ser Val Ala Ser Asn Leu Thr Thr Met Ala Val Leu Gly Leu Gly 195 200 205 Ala Phe Val Leu Leu Leu Gly Ser Tyr Thr Arg Ile Ile Met Thr Ala 210 215 220

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Leu Gly Ile Asn Ser Ala Thr Gly Arg Arg Lys Ile Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Leu Val Ile Thr Asn Phe Tyr Gly Ser Gly Val Ile

245 250 255

Arg Tyr Val Ile 260 <210> 1623 <211> 930 <212> DNA <213> Canis familiaris <400> 1623 atggcctgga ggaaccacag caccatcacg gagttcattc tccttgggct gtccgacgac 60 ccctacatcg aagctctgct ctttgtgttc ttcctgggga tctacctcct gactatgatg 120 gggaacctga tgatgctgct ggtgatcagg gctgattccc gcctccacac tcccatgtac 180 ttcttcctga gtaacctgtc cttcctagac ctctgcttct cttctgtcac tgtgcccaag 240 ctcctgaagg accttctgtc tgagaagaga accatctcag tggagggctg cctcacccag 300 gtgttctttg tgtttatcac tgcagggacc gaagcctttc tgctctcagt gatggcctat 360 gaccgctatg ctgccatctg ccacccactg ctctatggcc aggtgatgag cacccagttc 420 tgtgtgaagc tcgtgttgat ctcatggggt ctggcctgcc tgaattcggt tgtgattgtg 480 ttcttggcta ttaacctgga cttctgtgag gcccaaacta tacatcatta catctgtgag 540 ctgccctccc tcttccctct ctcttgctca gatatttcta tcaatgttga catcttgatc 600 tgctccatct tactgcatgg gcttgggacc ttcctcccaa tcttcttctc ctatgcccgt 660 attgtctcca ccatcctgag catcagctct acctcaggca gaagcaagac cttctccacc 720 tgctcttccc acctcattgc agtgactctg ttctttggct caggtttgat tcgctacctt 780 atgcccacct ccggttcctc cctggatttg ctctcctcct tgcagtacag tgcagtcaca 840 cccttgctga atcccctcat ctacagccta aagaataaag aagtgaaggc agctgtgaga 900 aggacactag gaaaatacct acactcttag 930 <210> 1624

Page 1823

069269_0225_SL.TXT <211> 309 <212> PRT <213> Canis familiaris

<400> 1624 Leu 15 Gly Met 1 Ala Trp Arg Asn His Ser Thr 5 Ile Thr 10 Glu Phe Ile Leu Leu Ser Asp Asp Pro Tyr Ile Glu Ala Leu Leu Phe Val Phe Phe Leu 20 25 30 Gly Ile Tyr Leu Leu Thr Met Met Gly Asn Leu Met Met Leu Leu Val 35 40 45 Ile Arg Ala Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Leu Leu Lys Asp Leu Leu Ser Glu Lys Arg Thr Ile Ser Val Glu Gly 85 90 95 Cys Leu Thr Gln Val Phe Phe Val Phe Ile Thr Ala Gly Thr Glu Ala 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Gly Gln Val Met Ser Thr Gln Phe Cys Val Lys Leu 130 135 140 Val Leu Ile Ser Trp Gly Leu Ala Cys Leu Asn Ser Val Val Ile Val 145 150 155 160 Phe Leu Ala Ile Asn Leu Asp Phe Cys Glu Ala Gln Thr Ile His His 165 170 175 Tyr Ile Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Ser Asp Ile 180 185 190

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Ser Ile Asn Val Asp Ile Leu Ile Cys Ser Ile Leu Leu His Gly Leu 195 200 205 Gly Thr Phe Leu Pro Ile Phe Phe Ser Tyr Ala Arg Ile Val Ser Thr 210 215 220 Ile Leu Ser Ile Ser Ser Thr Ser Gly Arg Ser Lys Thr Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ile Ala Val Thr Leu Phe Phe Gly Ser Gly Leu 245 250 255 Ile Arg Tyr Leu Met Pro Thr Ser Gly Ser Ser Leu Asp Leu Leu Ser 260 265 270 Ser Leu Gln Tyr Ser Ala Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Lys Asn Lys Glu Val Lys Ala Ala Val Arg Arg Thr Leu Gly 290 295 300 Lys Tyr Leu His Ser

305 <210> 1625 <211> 1005 <212> DNA <213> Canis familiaris <400> 1625

atggcctgga ggaaccacag caccatcacg gagttcattc tcattgggct gtccgacgac 60 ccctacatcg aagctctgct ctttgtgttc ttcctgggga tctacctcct gactgtgatg 120 gggaacctga taatgctgct ggtgatcagg gctgattccc gcctccacac tcccatgtac 180 ttcttcctga gtaacctgtc cttcctagac ctctgcttct cttctgtcac tgtgcccaag 240 ctcctaaagg accttctgtc tgagaagaga accatctcag tggagggctg cctcacccag 300 gtgttctttg tgtttatcac accagggacc gaagcctttc tgctctcagt gatggcctat 360 gaccgctatg ctgccatctg ccacccactg ctctatgacc aggtgatgag cacccagttc Page 1825 420

069269_0225_SL.TXT

tgtgtgaagc tggtgttgat ctcatggggt ctggcctgtc tcaatgcatt tatcattgtg 480 ctcttggcta ttaacctgga cttctgtgag gcccaaacca tacagcacta cacctgcgaa 540 ctgccctccc tcttccctct ctcttgctca gatatttcca tcaatgttga catcttgatc 600 tgctccacct tactgcatgg ccttgggacc ttcctcccaa tcttcttctc ctatgcccgt 660 atcgtctcca ccatcctgag catcagctcc acctcaggca gaagcaagac tttctccacc 720 tgctcttccc acctcattgc agtgacccta ttttttggct caggtttgat tcgctacctt 780 atgcccacaa ctggttcctc cctggatttg ctcctgtcct tgcagtacag tgctgtaaca 840 cccttgctga atcccctcat ctacagccta aagaataaag aggtgaaggc agctgtgaga 900 aggacactgg gaaaatatct cttaagtagt gacagacaca tggttacaaa gaccgggttc 960 ctttgcattt ctttttttgt tcccaccttc tcccacacac agtga 1005

<210> 1626 <211> 334 <212> PRT <213> Canis familiaris <400> 1626

Met Ala Trp Arg Asn His Ser Thr Ile Thr Glu Phe Ile Leu Ile Gly 1 5 10 15 Leu Ser Asp Asp Pro Tyr Ile Glu Ala Leu Leu Phe Val Phe Phe Leu 20 25 30 Gly Ile Tyr Leu Leu Thr Val Met Gly Asn Leu Ile Met Leu Leu Val 35 40 45 Ile Arg Ala Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Leu Leu Lys Asp Leu Leu Ser Glu Lys Arg Thr Ile Ser Val Glu Gly 85 90 95

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Cys Leu Thr Gln Val Phe Phe Val Phe Ile Thr Pro Gly Thr Glu Ala 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Asp Gln Val Met Ser Thr Gln Phe Cys Val Lys Leu 130 135 140 Val Leu Ile Ser Trp Gly Leu Ala Cys Leu Asn Ala Phe Ile Ile Val 145 150 155 160 Leu Leu Ala Ile Asn Leu Asp Phe Cys Glu Ala Gln Thr Ile Gln His 165 170 175 Tyr Thr Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Ser Asp Ile 180 185 190 Ser Ile Asn Val Asp Ile Leu Ile Cys Ser Thr Leu Leu His Gly Leu 195 200 205 Gly Thr Phe Leu Pro Ile Phe Phe Ser Tyr Ala Arg Ile Val Ser Thr 210 215 220 Ile Leu Ser Ile Ser Ser Thr Ser Gly Arg Ser Lys Thr Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ile Ala Val Thr Leu Phe Phe Gly Ser Gly Leu 245 250 255 Ile Arg Tyr Leu Met Pro Thr Thr Gly Ser Ser Leu Asp Leu Leu Leu 260 265 270 Ser Leu Gln Tyr Ser Ala Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Lys Asn Lys Glu Val Lys Ala Ala Val Arg Arg Thr Leu Gly 290 295 300

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Lys Tyr Leu Leu Ser Ser Asp Arg His Met Val Thr Lys Thr Gly Phe 305 310 315 320

Leu Cys Ile Ser Phe Phe Val Pro Thr Phe Ser His Thr Gln 325 330 <210> 1627 <211> 924 <212> DNA <213> Canis familiaris <400> 1627

atggcctgga ggaaccacag caccatcacg gagttcattc tcattgggct gtccgacgac 60 ccctatatcg aagctctgct ctttgtgttc ttcctgggga tctacctcct gactgtgatg 120 gggaacctga tgatgctgct ggtgatcagg gctgattccc gcctccacac tcccatgtac 180 ttcttcctga gtaacctgtc cttcctagac ctctgcttct cttctgtcac tgtgcccaag 240 ctcctgaagg accttctgtc tgagaagaga accatctcag tggagggctg cctcacccag 300 gtgttctttg tgtttatcac accagggact gaagcctttc tgctctcagt gatggcctat 360 gaccgctatg ctgccatctg ccacccactg ctctatggcc aggtgatgag cccccagttc 420 tgtgtgaagc tggtgttgat ctcatggggt ctggcctgtc tcaatgcatt tgtcattgtg 480 ttcttggcta ttaacctgga cttctgtgag gcccaaacca tacatcatta catctgtgag 540 ctgccctccc tcttccctct ctcttgctca gatatttcca tcagtgttga catcttgatc 600 tgctccatct tactacatgg gcttgggacc ttcctcccaa tcttcttctc ctatgcccgt 660 atcgtctcca ccatcctgag catcagctcc acctcaggca gaagcaagac tttctccacc 720 tgctcctccc acctcattgc agtgaccctg ttctttggct caggtgtgat tcgctacctt 780 atgcccacaa ctgattcctc cctggttttg ctcctgtcct tgcagtacag tgcagtcaca 840 cccttgctga atcccctcat ctacagccta aagaataaag aggtgaaggc agctgtgaga 900 aggacactgg ggaaatattt ctaa 924

<210> 1628 <211> 307 <212> PRT <213> Canis familiaris

Page 1828

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<400> 1628 Asn His Ser Thr Ile Thr Glu Phe Ile Leu Ile Gly 15 Met 1 Ala Trp Arg 5 10 Leu Ser Asp Asp Pro Tyr Ile Glu Ala Leu Leu Phe Val Phe Phe Leu 20 25 30 Gly Ile Tyr Leu Leu Thr Val Met Gly Asn Leu Met Met Leu Leu Val 35 40 45 Ile Arg Ala Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Leu Leu Lys Asp Leu Leu Ser Glu Lys Arg Thr Ile Ser Val Glu Gly 85 90 95 Cys Leu Thr Gln Val Phe Phe Val Phe Ile Thr Pro Gly Thr Glu Ala 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Gly Gln Val Met Ser Pro Gln Phe Cys Val Lys Leu 130 135 140 Val Leu Ile Ser Trp Gly Leu Ala Cys Leu Asn Ala Phe Val Ile Val 145 150 155 160 Phe Leu Ala Ile Asn Leu Asp Phe Cys Glu Ala Gln Thr Ile His His 165 170 175 Tyr Ile Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Ser Asp Ile 180 185 190 Ser Ile Ser Val Asp Ile Leu Ile Cys Ser Ile Leu Leu His Gly Leu 195 200 205

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Gly Thr 210 Phe Leu Pro Ile Phe Phe Ser Tyr Ala Arg Ile Val Ser Thr 215 220 Ile Leu Ser Ile Ser Ser Thr Ser Gly Arg Ser Lys Thr Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ile Ala Val Thr Leu Phe Phe Gly Ser Gly Val 245 250 255 Ile Arg Tyr Leu Met Pro Thr Thr Asp Ser Ser Leu Val Leu Leu Leu 260 265 270 Ser Leu Gln Tyr Ser Ala Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Lys Asn Lys Glu Val Lys Ala Ala Val Arg Arg Thr Leu Gly 290 295 300

Lys Tyr Phe 305 <210> 1629 <211> 924 <212> DNA <213> Canis familiaris <400> 1629

atggcctgga ggaaccacag caccatcacg gagttcattc tcattgggct gtccgacgac 60 ccctacatcg aagctctgct ctttgtgttc ttcctgggga tctacctcct gactgtgatg 120 gggaacctga tgctgctgct agtgatcagg gctgattctc gcctccacac tcccatgtac 180 ttcttcctga gtaacctgtc cttcatggac ctctgcttct cttctgtcac tgtgcccaag 240 ctactgaagg accttctgtc tgaaaagaaa accatctcag tggagggctg cctcacccag 300 gtgttctttg tgtttttctc ttcagggact gaagcttgtc tgctctcggt gatggcctat 360 gaccgctatg ctgccatctg ccacccactg ctctatggcc aggtgatgag cggccagttc 420 tgtgtgaagc tggtgttgat ctcatggggt ctggcctgtc tcaatgcatt tgtcattgtg 480 ctcttggcta ttaacctgga cttctgtgag gcccaaacca tacaccacta cacctgtgag 540

Page 1830

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ctgcctgccc ttttccctct gtcttgttcg gatatctcca tcactaccga tatcctgctg 600 tcctccagtt tattgcatgg gcttgggacc ttcctcccaa tcttcttctc ctatgctcgc 660 atcatctcca ccatcctgag catcagctcc acctcaggca gaagcaagac cttctccacc 720 tgctcctccc acctcattgc agtgaccttg ttctttggct caggttttct ttgttatctc 780 atgcctccct caggttcctc cctggatttt ctcatctcct tgcagtacag tgcagtcaca 840 cccctgctga atcccctcat ctacagctta aagaataaag aggtgaaggc ggctgtgaga 900 aggacactgg ggaaatatct ctaa 924

<210> 1630 <211> 307 <212> PRT <213> Canis familiaris

<400> 1630 His Ser Thr Ile Thr Glu Phe Ile Leu Ile Gly Met 1 Ala Trp Arg Asn 5 10 15 Leu Ser Asp Asp Pro Tyr Ile Glu Ala Leu Leu Phe Val Phe Phe Leu 20 25 30 Gly Ile Tyr Leu Leu Thr Val Met Gly Asn Leu Met Leu Leu Leu Val 35 40 45 Ile Arg Ala Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Met Asp Leu Cys Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Leu Leu Lys Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Val Glu Gly 85 90 95 Cys Leu Thr Gln Val Phe Phe Val Phe Phe Ser Ser Gly Thr Glu Ala 100 105 110 Cys Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125

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Pro Leu 130 Leu Tyr Gly Gln Val Met Ser Gly Gln Phe Cys Val Lys Leu 135 140 Val Leu Ile Ser Trp Gly Leu Ala Cys Leu Asn Ala Phe Val Ile Val 145 150 155 160 Leu Leu Ala Ile Asn Leu Asp Phe Cys Glu Ala Gln Thr Ile His His 165 170 175 Tyr Thr Cys Glu Leu Pro Ala Leu Phe Pro Leu Ser Cys Ser Asp Ile 180 185 190 Ser Ile Thr Thr Asp Ile Leu Leu Ser Ser Ser Leu Leu His Gly Leu 195 200 205 Gly Thr Phe Leu Pro Ile Phe Phe Ser Tyr Ala Arg Ile Ile Ser Thr 210 215 220 Ile Leu Ser Ile Ser Ser Thr Ser Gly Arg Ser Lys Thr Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ile Ala Val Thr Leu Phe Phe Gly Ser Gly Phe 245 250 255 Leu Cys Tyr Leu Met Pro Pro Ser Gly Ser Ser Leu Asp Phe Leu Ile 260 265 270 Ser Leu Gln Tyr Ser Ala Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Lys Asn Lys Glu Val Lys Ala Ala Val Arg Arg Thr Leu Gly 290 295 300

Lys Tyr Leu 305 <210> 1631 <211> 936

Page 1832

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 1631

atggccttga gaaaccacag caccagcact gagttcatcc tcctcgggct gtctgctgac 60 cccaaagtcc aggctctgct ctttgtgctc ttcctgggga tttatctcct gactgtgatg 120 gggaacctgg caatgctgct ggtgatcagt gctgatttcc acctccacac acccatgtac 180 ttcttcctga gtaacctgtc cttcctagac ctctgctttt cctcggtcac tgtgcccaag 240 atgctggaga acctcctatc taaaaggaaa atcatttcaa tagaaggatg cctgactcaa 300 gccttctttg tgtttgacgt tggaggaaca gaaattttcc tgctctctgc catggcctat 360 gaccgctatg cagccatctg ccaccctctg ctctacagcc gcatgatgag caaccagctg 420 tgtgtgaggc tggtatgggc ttcatggagc ctaggtttcc tggatgcagt tatcaacatc 480 cccctggcta tgaacttgaa cttctgtgag gcccatacca tcccccacta cagctgtgag 540 ctgccctccc tcttcccttt gtcctgctct gatgtctcta ccaacctcac tgtcctgctc 600 tgttccacac tcttgcatgg ctttggtaca ttcttcctga tattcttctc ttatgcacgc 660 attgtctcca ccatcctgag catcagctcc tccttgggca gaagcaaggc cttctccacc 720 tgctcctccc acctcactgc agtgagcttc ttctatggct cagctttcct ccgtcatctc 780 ataccaacct caggctcacc tctggagctg atcttctcca tacagtatgg tgtgatcact 840 cccctagtga atcccctcat ttacagcctg aaaaacaaag aagtaaaggc agctctaaga 900 agaaccttgg gaaagtgttt gcaatggcac aggtag 936

<210> 1632 <211> 311 <212> PRT <213> Canis familiaris <400> 1632

Met Ala Leu Arg Asn His Ser Thr Ser Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Ala Asp Pro Lys Val Gln Ala Leu Leu Phe Val Leu Phe Leu 20 25 30 Gly Ile Tyr Leu Leu Thr Val Met Gly Asn Leu Ala Met Leu Leu Val Page 183 3

069269_0225_SL.TXT 40 45

Ile Ser 50 Ala Asp Phe His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Asn Leu Leu Ser Lys Arg Lys Ile Ile Ser Ile Glu Gly 85 90 95 Cys Leu Thr Gln Ala Phe Phe Val Phe Asp Val Gly Gly Thr Glu Ile 100 105 110 Phe Leu Leu Ser Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Ser Arg Met Met Ser Asn Gln Leu Cys Val Arg Leu 130 135 140 Val Trp Ala Ser Trp Ser Leu Gly Phe Leu Asp Ala Val Ile Asn Ile 145 150 155 160 Pro Leu Ala Met Asn Leu Asn Phe Cys Glu Ala His Thr Ile Pro His 165 170 175 Tyr Ser Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Ser Asp Val 180 185 190 Ser Thr Asn Leu Thr Val Leu Leu Cys Ser Thr Leu Leu His Gly Phe 195 200 205 Gly Thr Phe Phe Leu Ile Phe Phe Ser Tyr Ala Arg Ile Val Ser Thr 210 215 220 Ile Leu Ser Ile Ser Ser Ser Leu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ser Phe Phe Tyr Gly Ser Ala Phe

Page 1834

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245 250 255

Leu Arg His Leu 260 Ile Pro Thr Ser Gly Ser Pro Leu Glu Leu Ile Phe 265 270 Ser Ile Gln Tyr Gly Val Ile Thr Pro Leu Val Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Lys Asn Lys Glu Val Lys Ala Ala Leu Arg Arg Thr Leu Gly 290 295 300 Lys Cys Leu Gln Trp His Arg 305 310

<210> 1633 <211> 948 <212> DNA <213> Canis familiaris <400> 1633 atggcctcag cgaatcacag cagaatcacg gagttcatcc ttcttgggct gtctgctgac 60 ccctatgtcc aggctctact ctttgttctg ttcctgatga tttaccttct gactctactg 120 gggaatcttc tgataatact tgtgatccat acagatgcta acctccacat gcccatgtac 180 ttctttctgg gccatctctc cttccaagac ctcttctact ctacagtcac tgtgcccaag 240 ctgctggaga acctcctgtc tcagaggaaa accatctcag tggagggctg cctggctcag 300 gtgttctttg tgtttgccac tacagggatt gaagcctgcc tgctttcggt gatggcctat 360 gaccgctatg ctgccatctg ccaccctctg ctttatggcc aggtgatgag taaacagcta 420 tgtgagaggt tggtgtgggg ctcttgggtc gtggcctttc tggatgcact catgaacatc 480 ctcctggctt tgaatatgga cttctgtgag gctcaaacca tccaccacta ctcctgtgag 540 ctgccttccc tcttccctct ctcctgctct gatgtctcca ccaactctgc aatgctactc 600 tgctctgccc tcctgcatgc cattgggaca tgcctcctga tcttcttctc ttatgtgcgc 660 attgtctcta ccatcctgag catcagctcc accacaggca gaagcaaggc cttctccacc 720 tgctcctccc acctcactgc agtgatcctg ttctatggct cagcccttct tcgctatctc 780 atgccaacct cagggtcacc tctagagttg atcctctcca tacaatacag tgtaatcact 840

Page 1835

069269_0225_SL.TXT cccttggtga atccactcat ctacagctgg aagaacaagg aggtgaaagc agctctgaga agaatgatga taaaatactt acgatgtctc agcacagaag agatataa

900

948 <210> 1634 <211> 315 <212> PRT <213> Canis familiaris

<400> 1634 His Ser Arg Ile Thr Glu Phe Ile Leu Leu Gly Met Ala 1 Ser Ala Asn 5 10 15 Leu Ser Ala Asp Pro Tyr Val Gln Ala Leu Leu Phe Val Leu Phe Leu 20 25 30 Met Ile Tyr Leu Leu Thr Leu Leu Gly Asn Leu Leu Ile Ile Leu Val 35 40 45 Ile His Thr Asp Ala Asn Leu His Met Pro Met Tyr Phe Phe Leu Gly 50 55 60 His Leu Ser Phe Gln Asp Leu Phe Tyr Ser Thr Val Thr Val Pro Lys 65 70 75 80 Leu Leu Glu Asn Leu Leu Ser Gln Arg Lys Thr Ile Ser Val Glu Gly 85 90 95 Cys Leu Ala Gln Val Phe Phe Val Phe Ala Thr Thr Gly Ile Glu Ala 100 105 110 Cys Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Gly Gln Val Met Ser Lys Gln Leu Cys Glu Arg Leu 130 135 140 Val Trp Gly Ser Trp Val Val Ala Phe Leu Asp Ala Leu Met Asn Ile 145 150 155 160

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Leu Leu Ala Leu Asn Met Asp Phe Cys Glu 170 Ala Gln Thr Ile His His 175 165 Tyr Ser Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Ser Asp Val 180 185 190 Ser Thr Asn Ser Ala Met Leu Leu Cys Ser Ala Leu Leu His Ala Ile 195 200 205 Gly Thr Cys Leu Leu Ile Phe Phe Ser Tyr Val Arg Ile Val Ser Thr 210 215 220 Ile Leu Ser Ile Ser Ser Thr Thr Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ile Leu Phe Tyr Gly Ser Ala Leu 245 250 255 Leu Arg Tyr Leu Met Pro Thr Ser Gly Ser Pro Leu Glu Leu Ile Leu 260 265 270 Ser Ile Gln Tyr Ser Val Ile Thr Pro Leu Val Asn Pro Leu Ile Tyr 275 280 285 Ser Trp Lys Asn Lys Glu Val Lys Ala Ala Leu Arg Arg Met Met Ile 290 295 300 Lys Tyr Leu Arg Cys Leu Ser Thr Glu Glu Ile 305 310 315 <210> 1635 <211> 957 <212> DNA <213> Canis familiaris <400> 1635 atggtcttag gaaaccacag caccatcaca gaattcatct tccttggact gtctgctgac ccccacatcc ί agattctgct ctttgtgctt ttcctagcaa tttacctcct gactatcatg gggaacctga tgataatgat agtgactatg actgataccc atctccacac ccccatgtac

120

180

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ttcttcttga gccacctctc cttcctggat ctttgtttaa cttcagtaat tgtgcccaag 240 atgctggaga atctcgtatc tcacaagaaa tcagtatcag tagaaggctg cctcactcag 300 gcatttttcg tgttttccat cgctggaact gaagtttttg tgctctctgc catggcctat 360 gaccgctata ctgccatctg ctaccccctg ctctatggcc agctgatgag taaacagttg 420 tgtgggggtc tggtatgggt ctcatgggca ctgggctttc tggatgctct cattaacacc 480 ctcatggctt ggaatttgga cttctgtgag gttcaggtca tccctcactt cagctgtgaa 540 ctgccatctc tattccctct atcttgctct gacatctcca ccaactttac agtcctggtg 600 tgctctgcca tcattcatgc ctctggaacc ttgcttctgg tcttcttctc atatactcgc 660 attgtctcca ccatcctgag catcagctcc acctcaggca gaagtaaagc cttctccacc 720 tgctcctccc acctcactgc agtgagcttt ttctatggat ctgcttttct tcgctatttc 780 atgccaatct caggctcacc tctggagctg attttctcca tacagtacag tgtggtcact 840 cctctaataa atccccttat ttacagcttg aagaacaagg aagtaaaatc agctctgaaa 900 agaatgctgc aaaaaggttt aaaacagctc agagagcaga gaacaggcag tggatga 957

<210> 1636 <211> 318 <212> PRT <213> Canis familiaris <400> 1636

Met 1 Val Leu Gly Asn His Ser Thr Ile Thr Glu Phe Ile Phe Leu Gly 5 10 15 Leu Ser Ala Asp Pro His Ile Gln Ile Leu Leu Phe Val Leu Phe Leu 20 25 30 Ala Ile Tyr Leu Leu Thr Ile Met Gly Asn Leu Met Ile Met Ile Val 35 40 45 Thr Met Thr Asp Thr His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Leu Asp Leu Cys Leu Thr Ser Val Ile Val Pro Lys 65 70 75 80

Page 1838

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Met Leu Glu Asn Leu Val Ser His 85 Lys Lys Ser Val Ser Val Glu Gly 90 95 Cys Leu Thr Gln Ala Phe Phe Val Phe Ser Ile Ala Gly Thr Glu Val 100 105 110 Phe Val Leu Ser Ala Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys Tyr 115 120 125 Pro Leu Leu Tyr Gly Gln Leu Met Ser Lys Gln Leu Cys Gly Gly Leu 130 135 140 Val Trp Val Ser Trp Ala Leu Gly Phe Leu Asp Ala Leu Ile Asn Thr 145 150 155 160 Leu Met Ala Trp Asn Leu Asp Phe Cys Glu Val Gln Val Ile Pro His 165 170 175 Phe Ser Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Ser Asp Ile 180 185 190 Ser Thr Asn Phe Thr Val Leu Val Cys Ser Ala Ile Ile His Ala Ser 195 200 205 Gly Thr Leu Leu Leu Val Phe Phe Ser Tyr Thr Arg Ile Val Ser Thr 210 215 220 Ile Leu Ser Ile Ser Ser Thr Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ser Phe Phe Tyr Gly Ser Ala Phe 245 250 255 Leu Arg Tyr Phe Met Pro Ile Ser Gly Ser Pro Leu Glu Leu Ile Phe 260 265 270 Ser Ile Gln Tyr Ser Val Val Thr Pro Leu Ile Asn Pro Leu Ile Tyr 275 280 285

Page 1839

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Ser Leu Lys Asn Lys Glu Val Lys Ser Ala Leu Lys Arg Met Leu Gln 290 295 300

Lys Gly Leu Lys Gln Leu Arg Glu Gln Arg Thr Gly Ser Gly 305 310 315 <210> 1637 <211> 537 <212> DNA <213> Canis familiaris <400> 1637 atggaagaca atatgacatc tatcacagag ttcaccctac tgggatttcc tcttggccca 60 aggattcaga tggttctctt tgggctcttc accctgttct acaccttcac cctgctgggg 120 aatgggctca tcctggggct catctcactg gaccccagac tgcacacccc catgtacttc 180 ttcctctccc acctggccat cgtcgatata gcctatgcct gcaacacggt gccccagatg 240 ctggtgaacc tcctgaggcc agacaagccc atctcctttg ctggctgtct gacacagacc 300 tttctctttc tgacctttgc tgtcacagaa tgtcttctcc tggtggtgat gtcctatgac 360 cggtatgtgg ccatctgcca ccccctccgc tattctgtga tcatgagctg gagagtctgc 420 atcaccctgg tgctgacttc ttggaccatt ggagtccttc tgtttttggt acatctcatg 480 ttacttctcc ccttaccctt ctgtagattc cagaaaatca atcacttttt ctgtgaa 537 <210> 1638 <211> 179 <212> PRT <213> Canis familiaris <400> 1638

Met Glu Asp Asn Met Thr Ser Ile Thr Glu Phe Thr Leu Leu Gly Phe 1 5 10 15 Pro Leu Gly Pro Arg Ile Gln Met Val Leu Phe Gly Leu Phe Thr Leu 20 25 30 Phe Tyr Thr Phe Thr Leu Leu Gly Asn Gly Leu Ile Leu Gly Leu Ile

35 40 45

Page 1840

Ser Leu 50 Asp Pro Arg Leu His 55 069269_0225_SL.TXT Thr Pro Met Tyr Phe Phe 60 Leu Ser His Leu Ala Ile Val Asp Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met 65 70 75 80 Leu Val Asn Leu Leu Arg Pro Asp Lys Pro Ile Ser Phe Ala Gly Cys 85 90 95 Leu Thr Gln Thr Phe Leu Phe Leu Thr Phe Ala Val Thr Glu Cys Leu 100 105 110 Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu Arg Tyr Ser Val Ile Met Ser Trp Arg Val Cys Ile Thr Leu Val 130 135 140 Leu Thr Ser Trp Thr Ile Gly Val Leu Leu Phe Leu Val His Leu Met 145 150 155 160 Leu Leu Leu Pro Leu Pro Phe Cys Arg Phe Gln Lys Ile Asn His Phe 165 170 175

Phe Cys Glu <210> 1639 <211> 927 <212> DNA <213> Canis familiaris <400> 1639 atgagtaaca agacgctagt aacagagttt atcctgcagg gcttttcaga gcacccagaa taccatatgc tcttattcag ctgtttcctc tccctctact ctgtggccct cacaggtaat atcctcatca ttttggccat caccttcaac cctgggctcc atacccccat gtactttttt ctcttcaact tggctactat ggatattatc tgcacctctt ccatcatgcc caaagcactg gagggtctgg tatcagagga gagctctatc tcttatgggg cctgcatggc ccagctctat

120

180

240

300

Page 1841

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tttctcacat gggctgcatc ctccgagctg ctcctcctca cggtcatggc ctatgaccgg 360 tatgcagcca tctgccaccc tctgcactac agcacgacaa tgagcatggc attctgcagt 420 aagctggcca caggtgtatg ggtgctttgt gccttcaaca cagccatcca cactgggctg 480 atgctgcggt taaatttctg tggccctaac gtcattaccc attttttctg tgaggtccct 540 cctctgttgc ttctctcctg tagctccacc tatgtgaaca gcatcatgat tgtcctagct 600 gatgcctttt atggcatatt gaacttcctg atgaccattg tgtcatacgg ctttattatc 660 tctagcatcc taaaaatgcg gactgcagag gggaagaaaa aagccttttc cacttgctct 720 tctcacctca ttgtggtgtg tatgtattat actgctgtct tctatgccta cataagccct 780 gtctccagct atagtccagg gaagagcaag ttggctggtg tactgtacac catattgagc 840 cctacactca accccctcat ctatactttg agaaacaagg aggtcaaggc agccctcagg 900 aagcttttct ccttctccag aaattaa 927

<210> 1640 <211> 308 <212> PRT <213> Canis familiaris <400> 1640

Met Ser 1 Asn Lys Thr 5 Leu Val Thr Glu Phe Ile Leu Gln Gly Phe Ser 10 15 Glu His Pro Glu Tyr His Met Leu Leu Phe Ser Cys Phe Leu Ser Leu 20 25 30 Tyr Ser Val Ala Leu Thr Gly Asn Ile Leu Ile Ile Leu Ala Ile Thr 35 40 45 Phe Asn Pro Gly Leu His Thr Pro Met Tyr Phe Phe Leu Phe Asn Leu 50 55 60 Ala Thr Met Asp Ile Ile Cys Thr Ser Ser Ile Met Pro Lys Ala Leu 65 70 75 80 Glu Gly Leu Val Ser Glu Glu Ser Ser Ile Ser Tyr Gly Ala Cys Met 85 90 95

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Ala Gln Leu Tyr 100 Phe Leu Thr Trp Ala Ala Ser Ser Glu Leu Leu Leu 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His Pro Leu 115 120 125 His Tyr Ser Thr Thr Met Ser Met Ala Phe Cys Ser Lys Leu Ala Thr 130 135 140 Gly Val Trp Val Leu Cys Ala Phe Asn Thr Ala Ile His Thr Gly Leu 145 150 155 160 Met Leu Arg Leu Asn Phe Cys Gly Pro Asn Val Ile Thr His Phe Phe 165 170 175 Cys Glu Val Pro Pro Leu Leu Leu Leu Ser Cys Ser Ser Thr Tyr Val 180 185 190 Asn Ser Ile Met Ile Val Leu Ala Asp Ala Phe Tyr Gly Ile Leu Asn 195 200 205 Phe Leu Met Thr Ile Val Ser Tyr Gly Phe Ile Ile Ser Ser Ile Leu 210 215 220 Lys Met Arg Thr Ala Glu Gly Lys Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Leu Ile Val Val Cys Met Tyr Tyr Thr Ala Val Phe Tyr Ala 245 250 255 Tyr Ile Ser Pro Val Ser Ser Tyr Ser Pro Gly Lys Ser Lys Leu Ala 260 265 270 Gly Val Leu Tyr Thr Ile Leu Ser Pro Thr Leu Asn Pro Leu Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Leu Arg Lys Leu Phe Ser 290 295 300

Page 1843

069269_0225_SL.TXT

Phe Ser Arg Asn

305 <210> 1641 <211> 954 <212> DNA <213> Canis familiaris <400> 1641

atggaaaagt cggtgatgga ggatgcaaga aaccacacag aagttcagga attcaccttg 60 gaaggttttc ctggtgtcca gcaccctgga aagattctct tcctggtgca tctgttggca 120 tacctggcct ccatcatggg aaacatactc ataatcacca ttacctgggc tgaccatcac 180 ctccagacac ccatgtactt cttcctcagc agtttctcct tttctgaatg ctgttttata 240 accactgtta ttccaaaatt gctggctatc tttctggtag ggaggcaatc aatttacttt 300 gctgcctgcc tcacacaaga ctttatcttt cttttcctgg gaataactgt tttcttcctt 360 atggctatat tatccctaga tcggtacttg gccatttgca aacctctgta ttacccaacc 420 atcatgaacc caaggatgtg tttccttctg gtcattgcct gtttagcttt gggattcatc 480 cttatggtgg ttccagttgt aatgctttcc cattcatcct tctgtggttc ccatatcata 540 tctcacttct gtaattttgg gcccctggtt tatctctcct gttctgatac cagatttact 600 gagatgttgg cctttgtcct tgatttgttt atccttttga catcccttat cataaccatc 660 attacctaca gcaacatagt aatcacaatt gtgcaactcc tatcagccaa ggagaaaaag 720 aaagctttct ccacctgctc ctctcacctc atagtcctct ctctgatgta tggcagctgt 780 gtctttatat atatgaaacc aaagcaaact aaagggctag actccaacag agaggctacc 840 cttgtgaaca tggtggtaac cacactgctc aaccctgtca tctctactct gcagaacaag 900 caggtccact gggctgtaag ggatactctg tccagggtta gactgaagaa atag 954

<210> 1642 <211> 317 <212> PRT <213> Canis familiaris <400> 1642

Met Glu Lys Ser Val Met Glu Asp Ala Arg Asn His Thr Glu Val Gln 1 5 10 15

Page 1844

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Glu Phe Thr Leu 20 Glu Gly Phe Pro Gly Val Gln His Pro Gly Lys Ile 25 30 Leu Phe Leu Val His Leu Leu Ala Tyr Leu Ala Ser Ile Met Gly Asn 35 40 45 Ile Leu Ile Ile Thr Ile Thr Trp Ala Asp His His Leu Gln Thr Pro 50 55 60 Met Tyr Phe Phe Leu Ser Ser Phe Ser Phe Ser Glu Cys Cys Phe Ile 65 70 75 80 Thr Thr Val Ile Pro Lys Leu Leu Ala Ile Phe Leu Val Gly Arg Gln 85 90 95 Ser Ile Tyr Phe Ala Ala Cys Leu Thr Gln Asp Phe Ile Phe Leu Phe 100 105 110 Leu Gly Ile Thr Val Phe Phe Leu Met Ala Ile Leu Ser Leu Asp Arg 115 120 125 Tyr Leu Ala Ile Cys Lys Pro Leu Tyr Tyr Pro Thr Ile Met Asn Pro 130 135 140 Arg Met Cys Phe Leu Leu Val Ile Ala Cys Leu Ala Leu Gly Phe Ile 145 150 155 160 Leu Met Val Val Pro Val Val Met Leu Ser His Ser Ser Phe Cys Gly 165 170 175 Ser His Ile Ile Ser His Phe Cys Asn Phe Gly Pro Leu Val Tyr Leu 180 185 190 Ser Cys Ser Asp Thr Arg Phe Thr Glu Met Leu Ala Phe Val Leu Asp 195 200 205 Leu Phe Ile Leu Leu Thr Ser Leu Ile Ile Thr Ile Ile Thr Tyr Ser 210 215 220

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Asn 225 Ile Val Ile Thr Ile 230 Val Gln Leu Leu Ser Ala Lys Glu Lys 235 Lys 240 Lys Ala Phe Ser Thr Cys Ser Ser His Leu Ile Val Leu Ser Leu Met 245 250 255 Tyr Gly Ser Cys Val Phe Ile Tyr Met Lys Pro Lys Gln Thr Lys Gly 260 265 270 Leu Asp Ser Asn Arg Glu Ala Thr Leu Val Asn Met Val Val Thr Thr 275 280 285 Leu Leu Asn Pro Val Ile Ser Thr Leu Gln Asn Lys Gln Val His Trp 290 295 300 Ala Val Arg Asp Thr Leu Ser Arg Val Arg Leu Lys Lys

305 310 315 <210> 1643 <211> 954 <212> DNA <213> Canis familiaris <400> 1643

atggaggtga ggaatgagac agtaatccga ggattcattc tggaagggtt tcctaccatc 60 cagtacttgg gaaacctctt cttcctggta catctgctgg catacgtggc ctctatcaca 120 ggaaatatgg tgatcatcat catcacttgg gttgattatc gtctccagac acccatgtat 180 attttactta gcactttctc cttctttgaa tgctgtttta tcaccacagt tgttcctaaa 240 ctgctgtcca tctttctttc aggaaggcaa acaatttcct ttactgcttg tgtcacacaa 300 gccttttctt ttctgttttt tgggtcaata attttcttcc tcatggctgt aatgtccttg 360 gatcgatact tggccatttg caagcctctg cattacccaa ccatcatgaa cctgaagact 420 tgcttcctcc tggtcatgat ctgttgtgct ttgcccttct ctctcatcac tggtctggta 480 gtaaaggtgt tccagttatc cttctgtggt cctcatgtca tcccccattt tttctgtgac 540 cttggccccc tgattcatct ctcctgttct gacaccaggt ctattgaaat gttggccttt 600

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gtcctcactt cctttatcct tttgacatca cttatcataa ccatcattgc ctatagcaac 660 atagtagtca caatcctgca actcccatca gccaaggaga aaaagaaagc tttctccacc 720 tgctcatctc acctcatagt cctctctctg atgtatggca gttgtgtctt tatatatgtg 780 aaaccaaaac aaacgaacag gatggactcc aacagggagg ctgcccttgt gaacacagta 840 gtgaccccgc tgctcaaccc tgttatttat actctgcgga acaagcaggt ccaccaggct 900 ttgagggatg ctctgtcctg ggtgaggttg <210> 1644 <211> 317 <212> PRT <213> Canis familiaris <400> 1644 cataaacaga gctttagagg gtaa 954 Met Glu Val Arg Asn Glu Thr Val Ile Arg Gly Phe Ile Leu Glu Gly 1 5 10 15 Phe Pro Thr Ile Gln Tyr Leu Gly Asn Leu Phe Phe Leu Val His Leu 20 25 30 Leu Ala Tyr Val Ala Ser Ile Thr 35 40 Gly Asn Met Val Ile Ile Ile Ile 45 Thr Trp Val Asp Tyr Arg Leu Gln 50 55 Thr Pro Met Tyr Ile Leu Leu Ser 60 Thr Phe Ser Phe Phe Glu Cys Cys Phe Ile Thr Thr Val Val Pro Lys 65 70 75 80 Leu Leu Ser Ile Phe Leu Ser Gly Arg Gln Thr Ile Ser Phe Thr Ala 85 90 95 Cys Val Thr Gln Ala Phe Ser Phe Leu Phe Phe Gly Ser Ile Ile Phe 100 105 110 Phe Leu Met Ala Val Met Ser Leu 115 120 Asp Arg Tyr Leu Ala Ile Cys Lys 125 Pro Leu His Tyr Pro Thr Ile Met Asn Leu Lys Thr Cys Phe Leu Leu

Page 1847

130 135 069269_0225_SL.TXT 140 Val Met Ile Cys Cys Ala Leu Pro Phe Ser Leu Ile Thr Gly Leu Val 145 150 155 160 Val Lys Val Phe Gln Leu Ser Phe Cys Gly Pro His Val Ile Pro His 165 170 175 Phe Phe Cys Asp Leu Gly Pro Leu Ile His Leu Ser Cys Ser Asp Thr 180 185 190 Arg Ser Ile Glu Met Leu Ala Phe Val Leu Thr Ser Phe Ile Leu Leu 195 200 205 Thr Ser Leu Ile Ile Thr Ile Ile Ala Tyr Ser Asn Ile Val Val Thr 210 215 220 Ile Leu Gln Leu Pro Ser Ala Lys Glu Lys Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ile Val Leu Ser Leu Met Tyr Gly Ser Cys Val 245 250 255 Phe Ile Tyr Val Lys Pro Lys Gln Thr Asn Arg Met Asp Ser Asn Arg 260 265 270 Glu Ala Ala Leu Val Asn Thr Val Val Thr Pro Leu Leu Asn Pro Val 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Gln Val His Gln Ala Leu Arg Asp Ala 290 295 300 Leu Ser Trp Val Arg Leu His Lys Gln Ser Phe Arg Gly 305 310 315

<210> 1645 <211> 723 <212> DNA <213> Canis familiaris

Page 1848

069269_0225_SL.TXT <400> 1645

tttcctcaca tccagcacct gggaaagttt ctcttcctgg tgcacctgct gacatacctg 60 gcatccattg caggcaatgc tgtcatagtc accatcatct gtgctaattc ccggctccag 120 acaccgatgt actttttcct cagcattttc tccttcttgg agtgttactt cataaatact 180 gttattccta agttattggt catctttctt tcaggtaagc aaaccatttc ttttcctgcc 240 tgtttcatac aagcctttgt ctttgtattt ctggaagcag caggtttctt cctcatagca 300 gtgatgtctc tggattggta tgtggccatt tgcaagcccc tgcattaccc gaccatcatg 360 aacctgaaga ctagttccct cctggtcact gcctgctgtg ctttggggtt ctctctaatc 420 actggtctgg tagtaaaggt ttcccagtta tccttctgtg gtccccatgt catcccccac 480 tttttttgtg accttggccc cctgattcat ctcttctgtt ctgacaccaa gtctgttgaa 540 atgttgatct ctgtccttgc tttgttaatc cttttgacat cccttatcat aaccatcatt 600 gactatagca acatagtagt cacaatcctg aaactcccat cagccaagga gaaaaagaaa 660 gctttctcca ccggctcctc tcacctcata gtcctctctc gaatgtatgg aagctgtgtc 720

ttt 723 <210> 1646 <211> 241 <212> PRT <213> Canis familiaris

<400> 1646 Phe Pro His Ile Gln His Leu Gly Lys Phe Leu Phe Leu Val His Leu 1 5 10 15 Leu Thr Tyr Leu Ala Ser Ile Ala Gly Asn Ala Val Ile Val Thr Ile 20 25 30 Ile Cys Ala Asn Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 35 40 45 Ile Phe Ser Phe Leu Glu Cys Tyr Phe Ile Asn Thr Val Ile Pro Lys 50 55 60 Leu Leu Val Ile Phe Leu Ser Gly Lys Gln Thr Ile Ser Phe Pro Ala 65 70 75 80

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Cys Phe Ile Gln Ala Phe Val Phe Val Phe Leu Glu Ala Ala Gly Phe 85 90 95 Phe Leu Ile Ala Val Met Ser Leu Asp Trp Tyr Val Ala Ile Cys Lys 100 105 110 Pro Leu His Tyr Pro Thr Ile Met Asn Leu Lys Thr Ser Ser Leu Leu 115 120 125 Val Thr Ala Cys Cys Ala Leu Gly Phe Ser Leu Ile Thr Gly Leu Val 130 135 140 Val Lys Val Ser Gln Leu Ser Phe Cys Gly Pro His Val Ile Pro His 145 150 155 160 Phe Phe Cys Asp Leu Gly Pro Leu Ile His Leu Phe Cys Ser Asp Thr 165 170 175 Lys Ser Val Glu Met Leu Ile Ser Val Leu Ala Leu Leu Ile Leu Leu 180 185 190 Thr Ser Leu Ile Ile Thr Ile Ile Asp Tyr Ser Asn Ile Val Val Thr 195 200 205 Ile Leu Lys Leu Pro Ser Ala Lys Glu Lys Lys Lys Ala Phe Ser Thr 210 215 220 Gly Ser Ser His Leu Ile Val Leu Ser Arg Met Tyr Gly Ser Cys Val 225 230 235 240

Phe <210> 1647 <211> 963 <212> DNA <213> Canis familiaris <400> 1647

Page 1850

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atgatgctgt ggaaagagat gcccatggaa atggagaatg ggacagctgt ccaggaattc 60 accttggaag ggttccctga catccagcac ctgggaaagt ttctcttcct ggtgcacctg 120 ctgacatacc tggcatccat tgcaggcaat gctgtcatag tcaccatcat ctgtgctaat 180 tcccggctcc agacacctat gtactttttc ctcagcattt tctcctttgt agagtgttgt 240 ttcataaata ctgttattcc taagttgtta gtcatctttc ttttaggcaa gcaaaacatt 300 tcctttcctg cctgtttcat acaagccttt ttctttttct ttctgggagc agcagatttc 360 tttctcatag cagtgatgtc tctggatcgg tatgtggcca tttgcaagcc cctgcattac 420 ttgaccatca tgaacctgaa gacttgctcc tttctggtca ctacctgctt cactttggcc 480 ttcactctca tcactggttt ggtagtgaaa gtttcccagt tatccttctg tggcccctat 540 gtcatccctc actttttctg tgacattggc cccctgattc atctttcctg ttctgacact 600 aaacctactg aaatgttggc ttttgtcctc gctttgttta tccttttgac atcccttatc 660 ataaccatca ttgcctacag caacataata gtcacaattg tacaactccc atcagctagg 720 gaacgacaga aagctttctc cacctgctcc tctcacctta tagtcctctc tctgatgtat 780 ggcagctgtg tctttatata tgtaaaacta aagcaaacga acaggatgga ctccaacagg 840 gaggctgccc ttgtgaacac ggtggtgacc ccgctgctca accctgtcat ttacactctg 900 cggaacaagc aggtccacca ggctctgaga gagacaatgt gcagaatgaa aatgtcaaga 960

tga 963 <210> 1648 <211> 320 <212> PRT <213> Canis familiaris <400> 1648

Met Met 1 Leu Trp Lys Glu 5 Met Pro Met Glu Met Glu Asn Gly Thr Ala 10 15 Val Gln Glu Phe Thr Leu Glu Gly Phe Pro Asp Ile Gln His Leu Gly 20 25 30 Lys Phe Leu Phe Leu Val His Leu Leu Thr Tyr Leu Ala Ser Ile Ala 35 40 45

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Gly Asn 50 Ala Val Ile Val Thr Ile 55 Ile Cys Ala Asn Ser Arg Leu 60 Gln Thr Pro Met Tyr Phe Phe Leu Ser Ile Phe Ser Phe Val Glu Cys Cys 65 70 75 80 Phe Ile Asn Thr Val Ile Pro Lys Leu Leu Val Ile Phe Leu Leu Gly 85 90 95 Lys Gln Asn Ile Ser Phe Pro Ala Cys Phe Ile Gln Ala Phe Phe Phe 100 105 110 Phe Phe Leu Gly Ala Ala Asp Phe Phe Leu Ile Ala Val Met Ser Leu 115 120 125 Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Leu Thr Ile Met 130 135 140 Asn Leu Lys Thr Cys Ser Phe Leu Val Thr Thr Cys Phe Thr Leu Ala 145 150 155 160 Phe Thr Leu Ile Thr Gly Leu Val Val Lys Val Ser Gln Leu Ser Phe 165 170 175 Cys Gly Pro Tyr Val Ile Pro His Phe Phe Cys Asp Ile Gly Pro Leu 180 185 190 Ile His Leu Ser Cys Ser Asp Thr Lys Pro Thr Glu Met Leu Ala Phe 195 200 205 Val Leu Ala Leu Phe Ile Leu Leu Thr Ser Leu Ile Ile Thr Ile Ile 210 215 220 Ala Tyr Ser Asn Ile Ile Val Thr Ile Val Gln Leu Pro Ser Ala Arg 225 230 235 240 Glu Arg Gln Lys Ala Phe Ser Thr Cys Ser Ser His Leu Ile Val Leu 245 250 255

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Ser Leu Met Tyr Gly Ser Cys Val Phe 265 Ile Tyr Val Lys Leu 270 Lys Gln 260 Thr Asn Arg Met Asp Ser Asn Arg Glu Ala Ala Leu Val Asn Thr Val 275 280 285 Val Thr Pro Leu Leu Asn Pro Val Ile Tyr Thr Leu Arg Asn Lys Gln 290 295 300 Val His Gln Ala Leu Arg Glu Thr Met Cys Arg Met Lys Met Ser Arg 305 310 315 320

<210> 1649 <211> 903 <212> DNA <213> Canis familiaris <400> 1649

acggagttca tcctgctggg cttcccagag ctgtgccacc ttcggggact gcttttcggg 60 ttattcctcg ccacctacct ggtgaccgtc ctggagaacc tggtcatcgt ggtgaccatc 120 cgagccagcc gccaactgca cacgcccatg tacttcttcc tggccaacct gtcagtgctg 180 gagaccctct acatctcggt caccgtcccc aagctgctgg cgggcctcct ggcgcgggcg 240 aggaccatct ccttcgcagg gtgcctcacg cagctgtttc tcttcctctc gctcggctcc 300 tccgagtgct tcctcctgac caccatggcc tgtgaccggt acctggccat ctgtcgcccg 360 ctgcgctacc cggccaccat gaaccggggg ctctgcctgt ggctggccct gggcgcctgg 420 ctgggcggct tcctggcctc gttcgtgtcc gtggctctca tctcgcgcct caggttctgt 480 ggccccaacg tcctcaacca cttcttctgc gacgtctcac ccctgctgca gctctcgtgc 540 tctgacacca gtgccgtgga agttctagac ttcgtggcag ccctggctgt gctcgccacc 600 tccctgctgg tgaccacggt gtcctacgtg cacatcctgg ccaccgtgct gaggatcccg 660 gggtgggcca gacgccggag agccttctcc acctgcgcct cccacctgct ggtggtggcc 720 gtcttctaca gcaccaccat cttcatgtac gcccggcctc gcgccgccag ctccatcgac 780 ctcaacaagc gggtgtccgt ggtctactca ctcgtgaccc cgctgctcaa ccccgtcttc 840 tactgcctgc gcaaccggga catcagggcg gctctggcca aactcctaca cgccccgggc 900

Page 1853

069269_0225_SL.TXT ctg

903 <210> 1650 <211> 301 <212> PRT <213> Canis familiaris

<400> 1650 Thr 1 Glu Phe Ile Leu Leu Gly Phe Pro Glu Leu Cys His Leu Arg Gly 15 5 10 Leu Leu Phe Gly Leu Phe Leu Ala Thr Tyr Leu Val Thr Val Leu Glu 20 25 30 Asn Leu Val Ile Val Val Thr Ile Arg Ala Ser Arg Gln Leu His Thr 35 40 45 Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser Val Leu Glu Thr Leu Tyr 50 55 60 Ile Ser Val Thr Val Pro Lys Leu Leu Ala Gly Leu Leu Ala Arg Ala 65 70 75 80 Arg Thr Ile Ser Phe Ala Gly Cys Leu Thr Gln Leu Phe Leu Phe Leu 85 90 95 Ser Leu Gly Ser Ser Glu Cys Phe Leu Leu Thr Thr Met Ala Cys Asp 100 105 110 Arg Tyr Leu Ala Ile Cys Arg Pro Leu Arg Tyr Pro Ala Thr Met Asn 115 120 125 Arg Gly Leu Cys Leu Trp Leu Ala Leu Gly Ala Trp Leu Gly Gly Phe 130 135 140 Leu Ala Ser Phe Val Ser Val Ala Leu Ile Ser Arg Leu Arg Phe Cys 145 150 155 160 Gly Pro Asn Val Leu Asn His Phe Phe Cys Asp Val Ser Pro Leu Leu 165 170 175

Page 1854

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Gln Leu Ser Cys Ser Asp Thr 180 Ser Ala Val Glu Val Leu Asp Phe Val 185 190 Ala Ala Leu Ala Val Leu Ala Thr Ser Leu Leu Val Thr Thr Val Ser 195 200 205 Tyr Val His Ile Leu Ala Thr Val Leu Arg Ile Pro Gly Trp Ala Arg 210 215 220 Arg Arg Arg Ala Phe Ser Thr Cys Ala Ser His Leu Leu Val Val Ala 225 230 235 240 Val Phe Tyr Ser Thr Thr Ile Phe Met Tyr Ala Arg Pro Arg Ala Ala 245 250 255 Ser Ser Ile Asp Leu Asn Lys Arg Val Ser Val Val Tyr Ser Leu Val 260 265 270 Thr Pro Leu Leu Asn Pro Val Phe Tyr Cys Leu Arg Asn Arg Asp Ile 275 280 285 Arg Ala Ala Leu Ala Lys Leu Leu His Ala Pro Gly Leu 290 295 300

<210> 1651 <211> 936 <212> DNA <213> Canis familiaris <400> 1651

atggcctggg gccgcagcca gaaccagtct gcgcaggagc ccttcatcct gctgggcttc 60 ccggggccgc tggggctgca cgtggggctc ttcgccctct tcctgctcat gtacgtgctg 120 gcggtggcgg gcaacctggc catcatcggc ctggtcgggg cgcacccgcg cctccggacg 180 cccatgtact tcttcctctg ccacctggcc ttcctggagg tctggttcac cacggcctgc 240 gtgcccaagg ccctggccac gctcgcctcc cgccgcggag ccatctcccc ggccggctgc 300 gcggcgcaga tgtacttcgt gttctcgctg ggctgcacgg agtacttcct gctggccgcg 360

Page 1855

069269_0225_SL.TXT

atggcctacg accgctacct ggccatctgc cggccgctgc gctatggcag cgtcatgacg 420 cccggcctgt gcgcccgcct ggcgctcggc tgctggctgt gcggcttctc ggccatcgcc 480 gtgcccgccg ccctcatcgc ccgcctctcc ttctgcggcg cccgcgtcat caaccacttc 540 ttctgcgaca tcgcgccctg gatcgcgctg tcctgcagcg acacgcgcgt ggtggagctg 600 gcgtccttcg gcatcgcctt ctgcgtcatc ctgggctcct gctccgtcac gctgctctcc 660 tacgcctgca tcatcgccac cgtcgtcagg atcccggccg gcgaggggcg gtgcagggcc 720 ttctccacct gctcctccca cctcactgtg gtcctcgtct ggtacggctc caccatcttc 780 ctgcacgtga ggatgtcggc ggagagctcg ctggacctca ccaaggccgt caccgtgctc 840 aacaccgctg tgaccccggt gctgaacccc ttcatttaca ccctgaggaa cagggaggtc 900 agggaggccc tgtggggctg ggtgcagggc aagtga 936

<210> 1652 <211> 312 <212> PRT <213> Canis familiaris <220>

<221> MOD_RES <222> (312)..(312) <223> Any amino acid <400> 1652

Gly Leu Gly Pro Gln Pro Glu Pro Val Cys Ala Gly Ala Leu His Pro 1 5 10 15 Ala Gly Leu Pro Gly Ala Ala Gly Ala Ala Arg Gly Ala Leu Arg Pro 20 25 30 Leu Pro Ala His Val Arg Ala Gly Gly Gly Gly Gln Pro Gly His His 35 40 45 Arg Pro Gly Arg Gly Ala Pro Ala Pro Pro Asp Ala His Val Leu Leu 50 55 60 Pro Leu Pro Pro Gly Leu Pro Gly Gly Leu Val His His Gly Leu Arg 65 70 75 80

Page 1856

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Ala Gln Gly Pro Gly 85 His Ala Arg Leu Pro Pro Arg Ser His Leu Pro 90 95 Gly Arg Leu Arg Gly Ala Asp Val Leu Arg Val Leu Ala Gly Leu His 100 105 110 Gly Val Leu Pro Ala Gly Arg Asp Gly Leu Arg Pro Leu Pro Gly His 115 120 125 Leu Pro Ala Ala Ala Leu Trp Gln Arg His Asp Ala Arg Pro Val Arg 130 135 140 Pro Pro Gly Ala Arg Leu Leu Ala Val Arg Leu Leu Gly His Arg Arg 145 150 155 160 Ala Arg Arg Pro His Arg Pro Pro Leu Leu Leu Arg Arg Pro Arg His 165 170 175 Gln Pro Leu Leu Leu Arg His Arg Ala Leu Asp Arg Ala Val Leu Gln 180 185 190 Arg His Ala Arg Gly Gly Ala Gly Val Leu Arg His Arg Leu Leu Arg 195 200 205 His Pro Gly Leu Leu Leu Arg His Ala Ala Leu Leu Arg Leu His His 210 215 220 Arg His Arg Arg Gln Asp Pro Gly Arg Arg Gly Ala Val Gln Gly Leu 225 230 235 240 Leu His Leu Leu Leu Pro Pro His Cys Gly Pro Arg Leu Val Arg Leu 245 250 255 His His Leu Pro Ala Arg Glu Asp Val Gly Gly Glu Leu Ala Gly Pro 260 265 270 His Gln Gly Arg His Arg Ala Gln His Arg Cys Asp Pro Gly Ala Glu 275 280 285

Page 1857

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Pro Leu His Leu His Pro Glu Glu Gln Gly Gly Gln Gly Gly Pro Val 290 295 300

Gly Leu Gly Ala Gly Gln Val Xaa 305 310 <210> 1653 <211> 957 <212> DNA <213> Canis familiaris <400> 1653

atgtgcgccc cggacaacgg ctccgaagtg acggagttca tcctggtggg cttcccgggc 60 ccggcgggct tccacgcggg cctgctggcg ctcttctcgc tggcctacgc gctcacggtc 120 acagagaacg cgctcatcgt ggcggtgatc cgcgtcagcc ccgcgctgca caagcccatg 180 tacgtcttcc tgggccacct gtccttcctg gagctgtggt acgtgtcggt cacggagccc 240 aagatgctgc tgggcctggc ggcgccgcgc ttccggcgca tctcgttcgc gggctgcatg 300 gcgcagctgt acttcttcct ggcgctggcc tgcaccgagt gcgcgctcct gggcgtcatg 360 gcctacgacc gctacgtggc catctgccgc ccgctgcgct acccggtcgt catgagcggc 420 cgcctctgcc gcctgctggc cgctggctcg tggctctcgg gcttcagcgt gtcgctgggg 480 aaggtcttct tcatctcgcg cctgggctac tgcggcccca acgtcatgaa ccacttcttc 540 tgcgacgtgt ccccgctgct gaacctggcg tgctccgaca tgtcgcgggc cgagctcgtg 600 gacttcctcc tggcgctgct ggtgctgctg ggcccgctgc tgctcaccgt gctgtcctac 660 ggcgccatcg tgagcgccgt gctgcgcgcc cgctccgccg ccggccgccg caaggccttc 720 tccacctgcg ccgcgcacct ggccgtggtg ctcgtcttct actcggcctc gctcttcatc 780 tacgcccggc cccgcgccat ctactccttc gacttcaaca agctggtgtc cgtggtctac 840 acggtgctca cgccgctgct caaccccatc atctactgcc tgcggaaccg ggaggtgaag 900 gacgcgctgc gcaaggcggc cgggagggcg gcctgggccc tgggtgcccg gtcttag 957

<210> 1654 <211> 319 <212> PRT <213> Canis familiaris

Page 1858

069269_0225_SL.TXT <220>

<221> MOD_RES <222> (319)..(319) <223> Any amino acid

<400> 1654 Val 1 Arg Pro Gly Gln 5 Arg Leu Arg Ser Asp Gly Val His Pro Gly Gly 10 15 Leu Pro Gly Pro Gly Gly Leu Pro Arg Gly Pro Ala Gly Ala Leu Leu 20 25 30 Ala Gly Leu Arg Ala His Gly His Arg Glu Arg Ala His Arg Gly Gly 35 40 45 Asp Pro Arg Gln Pro Arg Ala Ala Gln Ala His Val Arg Leu Pro Gly 50 55 60 Pro Pro Val Leu Pro Gly Ala Val Val Arg Val Gly His Gly Ala Gln 65 70 75 80 Asp Ala Ala Gly Pro Gly Gly Ala Ala Leu Pro Ala His Leu Val Arg 85 90 95 Gly Leu His Gly Ala Ala Val Leu Leu Pro Gly Ala Gly Leu His Arg 100 105 110 Val Arg Ala Pro Gly Arg His Gly Leu Arg Pro Leu Arg Gly His Leu 115 120 125 Pro Pro Ala Ala Leu Pro Gly Arg His Glu Arg Pro Pro Leu Pro Pro 130 135 140 Ala Gly Arg Trp Leu Val Ala Leu Gly Leu Gln Arg Val Ala Gly Glu 145 150 155 160 Gly Leu Leu His Leu Ala Pro Gly Leu Leu Arg Pro Gln Arg His Glu 165 170 175

Page 1859

069269_0225_SL.TXT

Pro Leu Leu Leu Arg Arg Val Pro Ala Ala Glu Pro Gly Val 190 Leu Arg 180 185 His Val Ala Gly Arg Ala Arg Gly Leu Pro Pro Gly Ala Ala Gly Ala 195 200 205 Ala Gly Pro Ala Ala Ala His Arg Ala Val Leu Arg Arg His Arg Glu 210 215 220 Arg Arg Ala Ala Arg Pro Leu Arg Arg Arg Pro Pro Gln Gly Leu Leu 225 230 235 240 His Leu Arg Arg Ala Pro Gly Arg Gly Ala Arg Leu Leu Leu Gly Leu 245 250 255 Ala Leu His Leu Arg Pro Ala Pro Arg His Leu Leu Leu Arg Leu Gln 260 265 270 Gln Ala Gly Val Arg Gly Leu His Gly Ala His Ala Ala Ala Gln Pro 275 280 285 His His Leu Leu Pro Ala Glu Pro Gly Gly Glu Gly Arg Ala Ala Gln 290 295 300 Gly Gly Arg Glu Gly Gly Leu Gly Pro Gly Cys Pro Val Leu Xaa 305 310 315 <210> 1655 <211> 933 <212> DNA <213> Canis familiaris <400> 1655 atgagcaacc ggacgctgct gacggagttc atcctgcagg gcttctccga cgcgccgcgg ctgcgcggcc ccttcttcgc gctcttcctc tgcctcttcg tggcggcgct gggcgggaat ctcctcatcg tggcggccat cgcctccagc ccgcggctcc acacgcccat gtacttcttc ctggtcaacc tgtctgtgct ggacgtcacc tgcgcgtgca ccgtggtgcc caagctgctg gacatcctgc tggcagagag gaggagcatc tcctacgggg gctgcatggc ccagatgtac

120

180

240

300

Page 1860

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ttcctgtcgt ggtcggtggc gggggaggtg ctgctcttca cggccatggc ctacgaccgc 360 tacgtggcca tctgccggcc gctgcgctac ggctccctca tgagccccag ggtgtgcgcg 420 gcgctggccg gcgccgtgtg gggcatcagc gtgctgggcg ccggggtcaa cacctgcctg 480 atgacgcggc tcagcttctg cgggcccaac gtgatcgatc acttcttctg cgagatcccc 540 cccgtgctgg tgctctcctg ctcctccacg ctcgtgaacg acatcatggc cgtgatggcc 600 gacatcttct tcgccatgct gaacttcctg ctcaccgtgg tgtcctacgg cttcatcatc 660 tccaccatcc tgaagatccg cacagccgag gggaagcagc gagccttctc cacctgctcc 720 tcccacctca ccgccgtcac cttgtactac tccaccatca tctacaccta cctgagccct 780 ggctccagct actccccagg gatgggcaag gtcatggccg tactgtactc cactgtgagc 840 cccaccctga accctctcat ctactccctc aagaacaagg aggtcaaggc agccctcagg 900 aaagtcttga cgctcgtggt caaaagcctg taa 933

<210> 1656 <211> 311 <212> PRT <213> Canis familiaris <220>

<221> MOD_RES <222> (311)..(311) <223> Any amino acid

<400> 1656 Glu Gln Pro Asp 1 Ala 5 Ala Asp Gly Val His Pro Ala Gly Leu Leu Arg 10 15 Arg Ala Ala Ala Ala Arg Pro Leu Leu Arg Ala Leu Pro Leu Pro Leu 20 25 30 Arg Gly Gly Ala Gly Arg Glu Ser Pro His Arg Gly Gly His Arg Leu 35 40 45 Gln Pro Ala Ala Pro His Ala His Val Leu Leu Pro Gly Gln Pro Val 50 55 60 Cys Ala Gly Arg His Leu Arg Val His Arg Gly Ala Gln Ala Ala Gly Page 1861

069269_0225_SL.TXT

His Pro Ala Gly Arg Glu Glu Glu His Leu Leu Arg Gly Leu His Gly 85 90 95 Pro Asp Val Leu Pro Val Val Val Gly Gly Gly Gly Gly Ala Ala Leu 100 105 110 His Gly His Gly Leu Arg Pro Leu Arg Gly His Leu Pro Ala Ala Ala 115 120 125 Leu Arg Leu Pro His Glu Pro Gln Gly Val Arg Gly Ala Gly Arg Arg 130 135 140 Arg Val Gly His Gln Arg Ala Gly Arg Arg Gly Gln His Leu Pro Asp 145 150 155 160 Asp Ala Ala Gln Leu Leu Arg Ala Gln Arg Asp Arg Ser Leu Leu Leu 165 170 175 Arg Asp Pro Pro Arg Ala Gly Ala Leu Leu Leu Leu His Ala Arg Glu 180 185 190 Arg His His Gly Arg Asp Gly Arg His Leu Leu Arg His Ala Glu Leu 195 200 205 Pro Ala His Arg Gly Val Leu Arg Leu His His Leu His His Pro Glu 210 215 220 Asp Pro His Ser Arg Gly Glu Ala Ala Ser Leu Leu His Leu Leu Leu 225 230 235 240 Pro Pro His Arg Arg His Leu Val Leu Leu His His His Leu His Leu 245 250 255 Pro Glu Pro Trp Leu Gln Leu Leu Pro Arg Asp Gly Gln Gly His Gly 260 265 270 Arg Thr Val Leu His Cys Glu Pro His Pro Glu Pro Ser His Leu Leu

Page 1862

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275 280 285

Pro Gln Glu Gln Gly Gly Gln Gly Ser Pro Gln Glu Ser Leu Asp Ala 290 295 300

Arg Gly Gln Lys Pro Val Xaa 305 310 <210> 1657 <211> 939 <212> DNA <213> Canis familiaris <400> 1657

atgagaaatc acacaaaggt aacagagttt attcttctcg ggttgaccga tgacccaaag 60 tggcaggttg tacttttcat atttcttctt gttacctaca tgttcagtgt gactgggaac 120 ctggtcatta tcatcctcac cctaacagat ccccacctga agactccaat gtatttcttc 180 cttcgaaact tctcattcct agaaatgtca ttcacctctg ttgcaattcc cagattcctt 240 gtcactgttg tgacgggaga cagaaccatt tcctacaatg actgtctggc tcaggtattt 300 ttcttcatct tattgggggc cacagagttt tacctcctga ctgccatgtc ctatgaccgc 360 tacattgcca tctgcaaacc tctgcattac atgaccatca tgagcagcag agtctgcatc 420 cttcttgtct ttagctcatg gcttgcagga ttcctgatca tctttccacc agtaattctg 480 gcgctgaagt tggatttctg tgcctccaat ataattgacc attttatctg tgactcttct 540 ccaattctac agctttcttg cacaaacact cactttctag aactcatggc atttatttta 600 gcggtggtaa cacttatggt caccttaacc ctagttatgc tctcctacat atacatcatc 660 cgcacaattc tgagaattcc ttccaggagt caaaggaaaa aagccttttc cacgtgttcc 720 tcccacatga tagtagtctc cctctcttat ggaagctgca tcttcatgta cattaagcct 780 tctgcaaagg aaagggtgag tttaaacaaa ggagtagctg tgatcattac ctcagtgact 840 cctctcttga atcctttcat atatacatta agaaaccagc aggtgaagca agccttcaag 900 aacatggtcc acagaatggc cttttcttca tataaatga 939

<210> 1658 <211> 312

Page 1863

069269_0225_SL.TXT <212> PRT <213> Canis familiaris <400> 1658

Met Arg Asn His Thr Lys Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asp Asp Pro Lys Trp Gln Val Val Leu Phe Ile Phe Leu Leu Val Thr 20 25 30 Tyr Met Phe Ser Val Thr Gly Asn Leu Val Ile Ile Ile Leu Thr Leu 35 40 45 Thr Asp Pro His Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Leu Glu Met Ser Phe Thr Ser Val Ala Ile Pro Arg Phe Leu 65 70 75 80 Val Thr Val Val Thr Gly Asp Arg Thr Ile Ser Tyr Asn Asp Cys Leu 85 90 95 Ala Gln Val Phe Phe Phe Ile Leu Leu Gly Ala Thr Glu Phe Tyr Leu 100 105 110 Leu Thr Ala Met Ser Tyr Asp Arg Tyr Ile Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Ser Ser Arg Val Cys Ile Leu Leu Val Phe 130 135 140 Ser Ser Trp Leu Ala Gly Phe Leu Ile Ile Phe Pro Pro Val Ile Leu 145 150 155 160 Ala Leu Lys Leu Asp Phe Cys Ala Ser Asn Ile Ile Asp His Phe Ile 165 170 175 Cys Asp Ser Ser Pro Ile Leu Gln Leu Ser Cys Thr Asn Thr His Phe 180 185 190

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Leu Glu Leu Met Ala Phe Ile Leu Ala Val 200 Val Thr Leu 205 Met Val Thr 195 Leu Thr Leu Val Met Leu Ser Tyr Ile Tyr Ile Ile Arg Thr Ile Leu 210 215 220 Arg Ile Pro Ser Arg Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Val Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Lys Pro Ser Ala Lys Glu Arg Val Ser Leu Asn Lys Gly Val 260 265 270 Ala Val Ile Ile Thr Ser Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asn Met Val His 290 295 300 Arg Met Ala Phe Ser Ser Tyr Lys 305 310

<210> 1659 <211> 822 <212> DNA <213> Canis familiaris <400> 1659

gtgacccagc tctttctctt tgccctcttc attgtggctg aagggtttct cctggctgcc 60 atggcttatg accgcttcat tgccatctgc aactcactcc tctactccgt ccagatgtca 120 acgtgcctct gcattcagtt ggtggctggt tcctattttt ttaatttctt tttattttta 180 tttattttta tttttttata ataaatttat tttttattgg tgttcaattt accaacatac 240 agaataacac ccagtgctca tcccgtcaag tgctcccctc agtgcccgac tcccattcac 300 ccccaccccc caccctccta tttttgtggc tgcatcagct cggttcttca gacgagaatg 360 acatttactt tgtccttttg tgcttcccaa gccatcgacc acttttactg tgatgaccat 420

Page 1865

069269_0225_SL.TXT ccacttcaaa agattacttg ctctgatctc tactttcata ggatagtttc ctttccctta 480 tgcagcatta ttattttgcc taccatcatt gtcattctcg tgtcctatat gtatattgtg 540 tccacagttc taaagataag atccactgag ggatgtaaga aagccttctc cacttgcagc 600 tctcatctag gagtcgtgag catcctgtac ggtgccatta tttttatgta tttcatccct 660 gacagattcc ctgagctgag taaagtggct ccttatgtta tacgttagtc actctcatgt 720 tgaatccttt gatttactcc ctgagaaaca aagatgtcaa agaggctctg agaaagatcc 780 tggggaaaaa tatttttatt taattctatc ttaacagtga ta 822 <210> 1660 <211> 66 <212> PRT <213> Canis familiaris

<400> 1660 Leu Phe Ala Leu Phe Ile Val Ala Glu Gly Phe Val 1 Thr Gln Leu Phe 5 10 15 Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Cys Asn Ser 20 25 30 Leu Leu Tyr Ser Val Gln Met Ser Thr Cys Leu Cys Ile Gln Leu Val 35 40 45 Ala Gly Ser Tyr Phe Phe Asn Phe Phe Leu Phe Leu Phe Ile Phe Ile 50 55 60

Phe Leu 65 <210> 1661 <211> 639 <212> DNA <213> Canis familiaris <400> 1661 gtaatttttt ttgtcctctt tggagcaaca gaattttttc tccttgccgc catgtcctat 60 gaccgctatg tggtcatttg caagcccctg cattatacaa cgatcatgaa taacagagtc 120 tgcactaccc tcgttctctg ctgttggttt gctggcctgt taatcatcct cccgcctctt 180

Page 1866

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ggcctgggcc tccagctgga attctgtgac tcaaatgtga ttgatcattt tggctgtgat 240 gcatctccaa ttttacagat aacctgctca gacacagtct taatagagag aattgttctg 300 agttttgccg tgctgacact cattatcacc ttagtgtgtg tagtcctctc ttatacctac 360 atcaagacca ttctaagatt cccttctgcc caacaaagga aaaaggtctt ttccacctgc 420 tcttcccata tgattgtggt ttccatcact tatggcagct gcatcttcat ctacatcaaa 480 ccttcagcaa aggaaggagt agctattaat aaagtggtgt ctgtgctcac tacttcagtt 540 gctcctttgt ttaacccatt catttataca cttcgaaaca aacaagtgaa agatgccttc 600 aaagacacag taaaatggat tgtatttctc acaaagaag 639

<210> 1662 <211> 213 <212> PRT <213> Canis familiaris

<400> 1662 Leu Phe Gly Ala Thr Glu Phe Phe Leu Leu Ala Val Ile 1 Phe Phe Val 5 10 15 Ala Met Ser Tyr Asp Arg Tyr Val Val Ile Cys Lys Pro Leu His Tyr 20 25 30 Thr Thr Ile Met Asn Asn Arg Val Cys Thr Thr Leu Val Leu Cys Cys 35 40 45 Trp Phe Ala Gly Leu Leu Ile Ile Leu Pro Pro Leu Gly Leu Gly Leu 50 55 60 Gln Leu Glu Phe Cys Asp Ser Asn Val Ile Asp His Phe Gly Cys Asp 65 70 75 80 Ala Ser Pro Ile Leu Gln Ile Thr Cys Ser Asp Thr Val Leu Ile Glu 85 90 95 Arg Ile Val Leu Ser Phe Ala Val Leu Thr Leu Ile Ile Thr Leu Val 100 105 110

Page 1867

Cys Val Val 115 Leu Ser Tyr Thr 069269_0225_SL.TXT Tyr Ile Lys Thr Ile Leu 120 125 Arg Phe Pro Ser Ala Gln Gln Arg Lys Lys Val Phe Ser Thr Cys Ser Ser His Met 130 135 140 Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile Tyr Ile Lys 145 150 155 160 Pro Ser Ala Lys Glu Gly Val Ala Ile Asn Lys Val Val Ser Val Leu 165 170 175 Thr Thr Ser Val Ala Pro Leu Phe Asn Pro Phe Ile Tyr Thr Leu Arg 180 185 190 Asn Lys Gln Val Lys Asp Ala Phe Lys Asp Thr Val Lys Trp Ile Val 195 200 205 Phe Leu Thr Lys Lys

210

<210> 1663 <211> 933 <212> DNA <213> Canis familiaris <400> 1663 atgaaaaatc attctgcaat aacattcatc ctactaggat taacagatga tccacgacta 60 caggtttttc tttcattatt tctgtttttc acctacattt tcactgttgc tggaaatcta 120 atcattatcc tcctcactct tgtagactct cacctcaaaa cacccatgta ctttttcctt 180 cggaattttt ccatcttaga aataatattt acaactgtct gtgttcctcg attcttatac 240 agcctgacaa ctggggacaa aagtgttacc tataatgctt gtgtcatcca attgtttttt 300 gttatcctca ttggagcaac agaatttttt cttctaaccg ccatgtgcta tgaccgctat 360 gtcgccatct gcaagccctt gcactacact atcatcatga atgaaagggt atgcacaatt 420 cttgtccttt gctgttggct gattgggtta attgtcatac tcccaccact tagcttggga 480 gttcagctag atttctgtaa ctccaatctc attgaccatt ttggttgtga tgcatctcct 540

Page 1868

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ctcctgaaga ttgtatgctc agacactcaa tttgtagagc aacttgtttt aatcatggct 600 gtgttgaccc tcatagtcac attagtctgt gtatttgtgt catacacata tattgtcaag 660 accattttaa gactcccttc agttcagcaa aggaaaaagg ctttctccac ttgttcttcc 720 catatgattg tagtttctat cacctatgga agttgcatct tcatctatat caaacctgca 780 aaggaaggag tggctcttaa taaggtagtg tcattgctca atacctcaat catccctttg 840 atgaaccctt tcatttatac actacggaat aagcaagtca aacaagcctt taaggactca 900 attaaaaaga tggcctttct ttcaaaggat tag 933

<210> 1664 <211> 310 <212> PRT <213> Canis familiaris <400> 1664

Met 1 Lys Asn His Ser 5 Ala Ile Thr Phe Ile Leu Leu Gly Leu Thr Asp 10 15 Asp Pro Arg Leu Gln Val Phe Leu Ser Leu Phe Leu Phe Phe Thr Tyr 20 25 30 Ile Phe Thr Val Ala Gly Asn Leu Ile Ile Ile Leu Leu Thr Leu Val 35 40 45 Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe Ser 50 55 60 Ile Leu Glu Ile Ile Phe Thr Thr Val Cys Val Pro Arg Phe Leu Tyr 65 70 75 80 Ser Leu Thr Thr Gly Asp Lys Ser Val Thr Tyr Asn Ala Cys Val Ile 85 90 95 Gln Leu Phe Phe Val Ile Leu Ile Gly Ala Thr Glu Phe Phe Leu Leu 100 105 110 Thr Ala Met Cys Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His 115 120 125

Page 1869

069269_0225_SL.TXT

Tyr Thr 130 Ile Ile Met Asn Glu Arg Val Cys Thr Ile Leu Val Leu Cys 135 140 Cys Trp Leu Ile Gly Leu Ile Val Ile Leu Pro Pro Leu Ser Leu Gly 145 150 155 160 Val Gln Leu Asp Phe Cys Asn Ser Asn Leu Ile Asp His Phe Gly Cys 165 170 175 Asp Ala Ser Pro Leu Leu Lys Ile Val Cys Ser Asp Thr Gln Phe Val 180 185 190 Glu Gln Leu Val Leu Ile Met Ala Val Leu Thr Leu Ile Val Thr Leu 195 200 205 Val Cys Val Phe Val Ser Tyr Thr Tyr Ile Val Lys Thr Ile Leu Arg 210 215 220 Leu Pro Ser Val Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Met Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile Tyr 245 250 255 Ile Lys Pro Ala Lys Glu Gly Val Ala Leu Asn Lys Val Val Ser Leu 260 265 270 Leu Asn Thr Ser Ile Ile Pro Leu Met Asn Pro Phe Ile Tyr Thr Leu 275 280 285 Arg Asn Lys Gln Val Lys Gln Ala Phe Lys Asp Ser Ile Lys Lys Met 290 295 300 Ala Phe Leu Ser Lys Asp

305 310 <210> 1665 <211> 939 <212> DNA

Page 1870

069269_0225_SL.TXT <213> Canis familiaris <400> 1665

atgagaaatc acacagcaat aacaacattc atcttgttgg gacttacaga ggacccacag 60 ctgcaagttc ttctttttat cttcttattt ctcagctacg tgctgagcat tactggaaat 120 ttgaccatta tcattcttac atttatggat tctcatctta aaacacctat gtattttttt 180 ctctgcaatt tctccatctt agaaatctca ttcacaacag tatgcattcc cagattcttg 240 tacagtataa caactggaga caacactatt acgtataatg cttgcgcttg ccaaatattt 300 tttattgggc tttttggggt cacagaattt tttctcctgg cagccatgtc ctatgaccgc 360 tatgtggcca tctgcaaacc ccttcattat atgaccatca tgaataacaa agtctgtacc 420 atccttgtcc tctgttgctg gatttctggg ctgctgatca tcatcacacc ccttggtatg 480 ggcctccagc tggaattctg tgactccaat gccattgatc attttggctg tgatgcatct 540 cctcttttta agatttcatg ctcggataca tgggttatag aacaggtggt tataatctgt 600 gcagtactga cattcattat tacactgata ggtgtcattc tttcctatat atatatcatc 660 aggacaattc taagattttc ttctgcttct caaagaaaaa aagctttctc cacctgttct 720 tcacacatgc ttgttgtttc cattacatac ggcagctgta ttttcatcta tatcaagcct 780 tcggccaaag aagaggtgga tatcaataaa ggggtatccg tgctcactac atctgttgct 840 cctttgttga accctttcat ttatactttg aggaacaagc aagtgaaacg agctttcaat 900 gacacaatca aaaaaattgc atttatctta cacaaataa 939

<210> 1666 <211> 312 <212> PRT <213> Canis familiaris

<400> 1666 Met Arg Asn His Thr Ala Ile Thr Thr Phe Ile Leu Leu Gly Leu Thr 1 5 10 15

Glu Asp Pro Gln Leu Gln Val Leu Leu Phe Ile Phe Leu Phe Leu Ser 20 25 30

Tyr Val Leu Ser Ile Thr Gly Asn Leu Thr Ile Ile Ile Leu Thr Phe 35 40 45

Page 1871

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Met Asp 50 Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Cys Asn Phe 55 60 Ser Ile Leu Glu Ile Ser Phe Thr Thr Val Cys Ile Pro Arg Phe Leu 65 70 75 80 Tyr Ser Ile Thr Thr Gly Asp Asn Thr Ile Thr Tyr Asn Ala Cys Ala 85 90 95 Cys Gln Ile Phe Phe Ile Gly Leu Phe Gly Val Thr Glu Phe Phe Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Asn Lys Val Cys Thr Ile Leu Val Leu 130 135 140 Cys Cys Trp Ile Ser Gly Leu Leu Ile Ile Ile Thr Pro Leu Gly Met 145 150 155 160 Gly Leu Gln Leu Glu Phe Cys Asp Ser Asn Ala Ile Asp His Phe Gly 165 170 175 Cys Asp Ala Ser Pro Leu Phe Lys Ile Ser Cys Ser Asp Thr Trp Val 180 185 190 Ile Glu Gln Val Val Ile Ile Cys Ala Val Leu Thr Phe Ile Ile Thr 195 200 205 Leu Ile Gly Val Ile Leu Ser Tyr Ile Tyr Ile Ile Arg Thr Ile Leu 210 215 220 Arg Phe Ser Ser Ala Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Leu Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile 245 250 255

Page 1872

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Tyr Ile Lys Pro Ser Ala Lys Glu Glu Val Asp Ile Asn Lys Gly Val 260 265 270 Ser Val Leu Thr Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Lys Arg Ala Phe Asn Asp Thr Ile Lys 290 295 300 Lys Ile Ala Phe Ile Leu His Lys

305 310 <210> 1667 <211> 972 <212> DNA <213> Canis familiaris <400> 1667

atggttagat ttcaaaagtc agtgatgaga aactatacag caataacaac ttttatcctg 60 ctgggactga cagacgaccc acaactgcaa atcctgctct ttatctttct atttctcacc 120 tacatcttga gcgtaacagg gaaccggact attatcaccc tcacactggt gaactcccat 180 cttaaaactc ctatgtactt ttttctgaga aatgtttcct tcttagaagt gtcattcacc 240 actgtctgca ttcctagatt cctgtatagc atatcaacag gggccaatac tattacctac 300 aatgcttgtg caagtcaaat atcttttgtt attctctttg gagcaactga attttttctc 360 ctggcagcca tgtcctatga tcgctatgtt gctatctgta aaccacttca ttacatgacc 420 atcatgagca atagggtgtg tagcttatta gtcttctgct gttgggtgtc tggcttgatg 480 atcattctcc caccccttag cttgtgcctc cagctggaat tctgtgactc gaatgccatc 540 gatcatttta gctgtgatgc aggtcccctc ctgaagatct catgttcaga tacatggatg 600 atagaacaaa tggttatcct tgtggctgta tttgcactca ttatcacctt agtgtgtgta 660 tttctgtcct acacatacat catcaggaca attctgagat tcccctctgt ccaacaaaga 720 aaaaaggcct tttccacctg ctcatcccac atgattgtag tttccatcac ctatggaagc 780 ggcatcttca tctatatcaa gtcatcagca aaagaagaga tagccataaa taaaggtgtt 840

Page 1873

069269_0225_SL.TXT tcggtgctca ctacttctgt tgcacccttg ctgaacccct tcttttacac cttgagaaat aagcaagtga aacaagcttt taatgacttc ataaagaaga tgacatttca ctcaaagaaa ctgaagtttt ga

900

960

972 <210> 1668 <211> 323 <212> PRT <213> Canis familiaris <400> 1668

Met Val 1 Arg Phe Gln Lys Ser Val Met Arg Asn Tyr Thr Ala Ile Thr 5 10 15 Thr Phe Ile Leu Leu Gly Leu Thr Asp Asp Pro Gln Leu Gln Ile Leu 20 25 30 Leu Phe Ile Phe Leu Phe Leu Thr Tyr Ile Leu Ser Val Thr Gly Asn 35 40 45 Arg Thr Ile Ile Thr Leu Thr Leu Val Asn Ser His Leu Lys Thr Pro 50 55 60 Met Tyr Phe Phe Leu Arg Asn Val Ser Phe Leu Glu Val Ser Phe Thr 65 70 75 80 Thr Val Cys Ile Pro Arg Phe Leu Tyr Ser Ile Ser Thr Gly Ala Asn 85 90 95 Thr Ile Thr Tyr Asn Ala Cys Ala Ser Gln Ile Ser Phe Val Ile Leu 100 105 110 Phe Gly Ala Thr Glu Phe Phe Leu Leu Ala Ala Met Ser Tyr Asp Arg 115 120 125 Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Ile Met Ser Asn 130 135 140 Arg Val Cys Ser Leu Leu Val Phe Cys Cys Trp Val Ser Gly Leu Met 145 150 155 160

Page 1874

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Ile Ile Leu Pro Pro 165 Leu Ser Leu Cys Leu Gln Leu Glu Phe Cys Asp 170 175 Ser Asn Ala Ile Asp His Phe Ser Cys Asp Ala Gly Pro Leu Leu Lys 180 185 190 Ile Ser Cys Ser Asp Thr Trp Met Ile Glu Gln Met Val Ile Leu Val 195 200 205 Ala Val Phe Ala Leu Ile Ile Thr Leu Val Cys Val Phe Leu Ser Tyr 210 215 220 Thr Tyr Ile Ile Arg Thr Ile Leu Arg Phe Pro Ser Val Gln Gln Arg 225 230 235 240 Lys Lys Ala Phe Ser Thr Cys Ser Ser His Met Ile Val Val Ser Ile 245 250 255 Thr Tyr Gly Ser Gly Ile Phe Ile Tyr Ile Lys Ser Ser Ala Lys Glu 260 265 270 Glu Ile Ala Ile Asn Lys Gly Val Ser Val Leu Thr Thr Ser Val Ala 275 280 285 Pro Leu Leu Asn Pro Phe Phe Tyr Thr Leu Arg Asn Lys Gln Val Lys 290 295 300 Gln Ala Phe Asn Asp Phe Ile Lys Lys Met Thr Phe His Ser Lys Lys 305 310 315 320

Leu Lys Phe <210> 1669 <211> 936 <212> DNA <213> Canis familiaris <400> 1669 atgaaaaatt atacagcaat aacaacattc atcttggtgg gattaacaaa tgacccacat

Page 1875

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ctacagattc tgctttttat ttttctattt ctaacctact tgttgagtgt tgtagggaat 120 ctgaccatta tcagcctcac gttggtggat tcccacctta aaacacccat gtattttttc 180 ctccagaatt tctccatctt ggaagtgttc tttaccactg tctgcattcc tagattcctc 240 tacacaatgg catctgggga caataccgtt acctacgatg catgtgccac tcaattattt 300 tttgttgtca tattgggtgt gactgaattt ttcctcctca cagccatgtc ctatgaccgc 360 tatgtggcca tctgcaaacc cctgcattac atgaccatca tgaacaacag ggtctgcatc 420 aagttcctta ttggatgtta tatgttagct ctgctcatcg tcctcccacc ctatatcatg 480 ggcttcaagc tcgagttttg tgactccaat gtcatagatc actttggctg tgatgctgct 540 cccatcctga agattacctg ctcagacaca gagtttatcg agcgatttgt cttggtcctg 600 gctgtgttga ccctcatttt caccttggtg tgtgtaattc tgtcctacac atacatcatt 660 aggaccattc tcagatttcc ttctgtccag caaaggaaaa aggctttttc tacttgttct 720 tcccatataa ttgtggtttc tattacttat ggaagctgca tctttatcta tatcaaacct 780 catgcaaaag aaggggttgc tattaataag gtggtgtcag tgcttaccac ttcagttgcc 840 ccagtgatga atccctttat ttatactctg aggaacaagc aagtggtaca agctttcaaa 900 gacatgatca aaagagttgc atctatctca aagaat 936

<210> 1670 <211> 312 <212> PRT <213> Canis familiaris <400> 1670

Met 1 Lys Asn Tyr Thr 5 Ala Ile Thr Thr Phe Ile Leu 10 Val Gly Leu 15 Thr Asn Asp Pro His Leu Gln Ile Leu Leu Phe Ile Phe Leu Phe Leu Thr 20 25 30 Tyr Leu Leu Ser Val Val Gly Asn Leu Thr Ile Ile Ser Leu Thr Leu 35 40 45 Val Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Gln Asn Phe 50 55 60

Page 1876

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Ser 65 Ile Leu Glu Val Phe Phe Thr Thr Val Cys Ile Pro Arg Phe Leu 70 75 80 Tyr Thr Met Ala Ser Gly Asp Asn Thr Val Thr Tyr Asp Ala Cys Ala 85 90 95 Thr Gln Leu Phe Phe Val Val Ile Leu Gly Val Thr Glu Phe Phe Leu 100 105 110 Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Asn Arg Val Cys Ile Lys Phe Leu Ile 130 135 140 Gly Cys Tyr Met Leu Ala Leu Leu Ile Val Leu Pro Pro Tyr Ile Met 145 150 155 160 Gly Phe Lys Leu Glu Phe Cys Asp Ser Asn Val Ile Asp His Phe Gly 165 170 175 Cys Asp Ala Ala Pro Ile Leu Lys Ile Thr Cys Ser Asp Thr Glu Phe 180 185 190 Ile Glu Arg Phe Val Leu Val Leu Ala Val Leu Thr Leu Ile Phe Thr 195 200 205 Leu Val Cys Val Ile Leu Ser Tyr Thr Tyr Ile Ile Arg Thr Ile Leu 210 215 220 Arg Phe Pro Ser Val Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Ile Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile 245 250 255 Tyr Ile Lys Pro His Ala Lys Glu Gly Val Ala Ile Asn Lys Val Val 260 265 270

Page 1877

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Ser Val Leu Thr Thr Ser Val Ala Pro Val Met Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Val Gln Ala Phe Lys Asp Met Ile Lys 290 295 300 Arg Val Ala Ser Ile Ser Lys Asn 305 310

<210> 1671 <211> 942 <212> DNA <213> Canis familiaris <400> 1671

atgttagcaa tgaaaaacca aacccttctg acagaattca ttctcctggg actaacagaa 60 atcccagaga tccaatttgt agtctttcta tttctcttcc tcacctacat attcagcatc 120 attggaaacc tcacaatcat cacacttaca ctactggact cacacctcca gactcccatg 180 tatttcttcc tccggaattt ctccttccta gaaatttcct ttacaaccac ctttactcct 240 aggctgctgt tcagcatcac aactggcaac aagagcatta gctttgctgg ctgcttcact 300 cagtatttct ttgccatctt ctttggagcc acagagtttt accttctggc tgccatgtcc 360 tatgaccgct atgtggctat atgcaaaccc ctgcattaca tgaccattat gagcaacaga 420 gtctgcattc agctggtttt cttctcttgg ttggctggat ttctaatcat catatcccca 480 atcatcctga ccagtcagct ggatttctgt gcctccaaca tactgaatca ttattattgt 540 gactacggac ccctgctaga aatatcttgc tcagacacaa gactcttaga gctggttgac 600 tttatcttag cagctgtgac gttggtggtc accctggtgc tggtgattct ctcctacaca 660 agcatcatct ggaccatcct caagatccca tctgctcagc aaaggaaaaa ggccttttcc 720 acatgttttt cccacatgat tgtcattgcc ctttcttatg gcagctgcat cttcatgtat 780 ataaaaccct cagccaaaga aggagttgcc ttcaataagg gggtagctgt gctcaatacc 840 tcagttgccc ctttattgaa cccattcatt tacactttaa ggaataaaca agtaaaacag 900 gccttcaagg atgtcatcaa aaaggttatg agcatttggt ga 942

Page 1878

069269_0225_SL.TXT <210> 1672 <211> 313 <212> PRT <213> Canis familiaris

<400> 1672 Asn Gln Thr Leu Leu Thr Glu Phe Ile Leu Leu Met 1 Leu Ala Met Lys 5 10 15 Gly Leu Thr Glu Ile Pro Glu Ile Gln Phe Val Val Phe Leu Phe Leu 20 25 30 Phe Leu Thr Tyr Ile Phe Ser Ile Ile Gly Asn Leu Thr Ile Ile Thr 35 40 45 Leu Thr Leu Leu Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu 50 55 60 Arg Asn Phe Ser Phe Leu Glu Ile Ser Phe Thr Thr Thr Phe Thr Pro 65 70 75 80 Arg Leu Leu Phe Ser Ile Thr Thr Gly Asn Lys Ser Ile Ser Phe Ala 85 90 95 Gly Cys Phe Thr Gln Tyr Phe Phe Ala Ile Phe Phe Gly Ala Thr Glu 100 105 110 Phe Tyr Leu Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Lys Pro Leu His Tyr Met Thr Ile Met Ser Asn Arg Val Cys Ile Gln 130 135 140 Leu Val Phe Phe Ser Trp Leu Ala Gly Phe Leu Ile Ile Ile Ser Pro 145 150 155 160 Ile Ile Leu Thr Ser Gln Leu Asp Phe Cys Ala Ser Asn Ile Leu Asn 165 170 175 His Tyr Tyr Cys Asp Tyr Gly Pro Leu Leu Glu Ile Ser Cys Ser Asp

Page 1879

180

069269_0225_SL.TXT 185 190

Thr Arg Leu Leu Glu Leu Val Asp Phe Ile Leu Ala Ala Val Thr Leu 195 200 205 Val Val Thr Leu Val Leu Val Ile Leu Ser Tyr Thr Ser Ile Ile Trp 210 215 220 Thr Ile Leu Lys Ile Pro Ser Ala Gln Gln Arg Lys Lys Ala Phe Ser 225 230 235 240 Thr Cys Phe Ser His Met Ile Val Ile Ala Leu Ser Tyr Gly Ser Cys 245 250 255 Ile Phe Met Tyr Ile Lys Pro Ser Ala Lys Glu Gly Val Ala Phe Asn 260 265 270 Lys Gly Val Ala Val Leu Asn Thr Ser Val Ala Pro Leu Leu Asn Pro 275 280 285 Phe Ile Tyr Thr Leu Arg Asn Lys Gln Val Lys Gln Ala Phe Lys Asp 290 295 300 Val Ile Lys Lys Val Met Ser Ile Trp

305 310 <210> 1673 <211> 891 <212> DNA <213> Canis familiaris <400> 1673

atgaaaaatc attctgcaat aacattcatc ctactaggat taacagatga tccacgacta 60 caggtttttc tttcattatt tctgttttta acctacattt tcactgttgc tggaaatcta 120 atcattatcc tcctcactct tgtagactct cacctcaaaa catccatgta ctttttcctt 180 cggaattttt ccatcttaga aataatattt acaactgtct gtgttcctcg attcttatac 240 agcctgacaa ctggggacaa aagtgttacc tataatgctt gtgtcatcca attatttttt 300 gttatcctca ttggagcaac agaatttttt cttctaaccg ccatgtgcta tgactgctat 360

Page 1880

069269_0225_SL.TXT

gttgccatct gcaagccctt gcactacact atcatcatga atgaaagagg atgcacaatt 420 cttgtccttt gctgttggct gattgggtta attgtcatac tcccaccact tatcctggga 480 gttcagctag atttctgtaa ctccaatctc attgaccatt ttggttgtga tgcatctcct 540 ctcctgaata ttgtatgctc agacgctcaa tttgtagagc aacttgtttt aatcatggct 600 gtgttgaccc tcatagtcac attagtctgt gtatttgtgt catacacata tattgtcaag 660 accattttaa gactcccttc agctcagcaa aggaagaagg ctttcttcac ttgttcttcc 720 catatgattg taatttccat cacctatgga agttgcatct tcatcttcat ttcattgctc 780 aatacctcaa tcatcccttt gatgaaccct ttcatttata cactacggaa taagcaagtc 840 aaacaagcct ttaaggactc aattaaaaag atggcatttc tttcaaagga t 891

<210> 1674 <211> 297 <212> PRT <213> Canis familiaris <400> 1674

Met Lys Asn His Ser Ala Ile Thr Phe Ile Leu Leu Gly Leu Thr Asp 1 5 10 15 Asp Pro Arg Leu Gln Val Phe Leu Ser Leu Phe Leu Phe Leu Thr Tyr 20 25 30 Ile Phe Thr Val Ala Gly Asn Leu Ile Ile Ile Leu Leu Thr Leu Val 35 40 45 Asp Ser His Leu Lys Thr Ser Met Tyr Phe Phe Leu Arg Asn Phe Ser 50 55 60 Ile Leu Glu Ile Ile Phe Thr Thr Val Cys Val Pro Arg Phe Leu Tyr 65 70 75 80 Ser Leu Thr Thr Gly Asp Lys Ser Val Thr Tyr Asn Ala Cys Val Ile 85 90 95 Gln Leu Phe Phe Val Ile Leu Ile Gly Ala Thr Glu Phe Phe Leu Leu 100 105 110

Page 1881

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Thr Ala Met Cys Tyr Asp Cys Tyr Val Ala Ile Cys Lys Pro Leu 125 His 115 120 Tyr Thr Ile Ile Met Asn Glu Arg Gly Cys Thr Ile Leu Val Leu Cys 130 135 140 Cys Trp Leu Ile Gly Leu Ile Val Ile Leu Pro Pro Leu Ile Leu Gly 145 150 155 160 Val Gln Leu Asp Phe Cys Asn Ser Asn Leu Ile Asp His Phe Gly Cys 165 170 175 Asp Ala Ser Pro Leu Leu Asn Ile Val Cys Ser Asp Ala Gln Phe Val 180 185 190 Glu Gln Leu Val Leu Ile Met Ala Val Leu Thr Leu Ile Val Thr Leu 195 200 205 Val Cys Val Phe Val Ser Tyr Thr Tyr Ile Val Lys Thr Ile Leu Arg 210 215 220 Leu Pro Ser Ala Gln Gln Arg Lys Lys Ala Phe Phe Thr Cys Ser Ser 225 230 235 240 His Met Ile Val Ile Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile Phe 245 250 255 Ile Ser Leu Leu Asn Thr Ser Ile Ile Pro Leu Met Asn Pro Phe Ile 260 265 270 Tyr Thr Leu Arg Asn Lys Gln Val Lys Gln Ala Phe Lys Asp Ser Ile 275 280 285 Lys Lys Met Ala Phe Leu Ser Lys Asp 290 295

<210> 1675 <211> 936

Page 1882

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 1675

atgaatcaca cagtgatcac caagtttgtc ctgctaggcc tttctgatga tcctgacctt 60 cagattgtga ttttcctctt cttattcgtc acatacttac taagtgtcac tggaaacctg 120 actatcatca ccctaacctt ggtggactct catctacaga cgccaatgta tttcttcctc 180 cgaaacttct ctttcttaga aatcttattt acaactgtat gtattcctag atttctgggg 240 gcaattatca ccagggataa gactatttcc tataacgact ctgcagtcca gctgtttttc 300 tttattttaa tgggggtgat ggaattttac attctcactg ccatgtctta tgacggctat 360 gttgccatct gcaagcccct tcattacacc accatcatga tcaggaaggt ctgcactcta 420 cttgtgctct gtgcatggct cggtgggttc ttgaccattt tcccacccct tatgcttcta 480 ctccagctga attactgtgc ttccaatgtc attgaccact ttgcatgtga ctattttccc 540 cttttacaac tgtcttgttc agatacgtgg ctcctagagg taattggttt ctactttgat 600 ttagttgcct tgctattcac tttggccttg gtgattttat cttatctgta tataatcaga 660 actattttga gaatcccatc tgccagtcag agaaaaaagg ctttctccac atgttcttct 720 catatgattg tcatttccat ttcttatggg agctgtatat ttatgtatgc taatccctct 780 gcaaaagaaa gggcatcatt gaccaaagga gtagctattc tcaatacttc tgttgccccc 840 atgctgaacc cttttattta cactctgaga aaccagcaag taaaacaagc tttcaaagat 900 atggtccata aagtagtatt ttcttcaagt aaatga 936

<210> 1676 <211> 311 <212> PRT <213> Canis familiaris <400> 1676

Met Asn His Thr Val Ile Thr Lys Phe Val Leu Leu Gly Leu Ser Asp

1 5 10 15

Asp Pro Asp Leu Gln Ile Val Ile Phe Leu Phe Leu Phe Val Thr Tyr

20 25 30

Leu Leu Ser Val Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu Val Page 1883

069269_0225_SL.TXT 40 45

Asp Ser 50 His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe Ser 55 60 Phe Leu Glu Ile Leu Phe Thr Thr Val Cys Ile Pro Arg Phe Leu Gly 65 70 75 80 Ala Ile Ile Thr Arg Asp Lys Thr Ile Ser Tyr Asn Asp Ser Ala Val 85 90 95 Gln Leu Phe Phe Phe Ile Leu Met Gly Val Met Glu Phe Tyr Ile Leu 100 105 110 Thr Ala Met Ser Tyr Asp Gly Tyr Val Ala Ile Cys Lys Pro Leu His 115 120 125 Tyr Thr Thr Ile Met Ile Arg Lys Val Cys Thr Leu Leu Val Leu Cys 130 135 140 Ala Trp Leu Gly Gly Phe Leu Thr Ile Phe Pro Pro Leu Met Leu Leu 145 150 155 160 Leu Gln Leu Asn Tyr Cys Ala Ser Asn Val Ile Asp His Phe Ala Cys 165 170 175 Asp Tyr Phe Pro Leu Leu Gln Leu Ser Cys Ser Asp Thr Trp Leu Leu 180 185 190 Glu Val Ile Gly Phe Tyr Phe Asp Leu Val Ala Leu Leu Phe Thr Leu 195 200 205 Ala Leu Val Ile Leu Ser Tyr Leu Tyr Ile Ile Arg Thr Ile Leu Arg 210 215 220 Ile Pro Ser Ala Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Met Ile Val Ile Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met Tyr

Page 1884

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245 250 255

Ala Asn Pro Ser Ala Lys Glu Arg Ala Ser Leu Thr Lys Gly Val Ala 260 265 270 Ile Leu Asn Thr Ser Val Ala Pro Met Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asp Met Val His Lys 290 295 300 Val Val Phe Ser Ser Ser Lys 305 310

<210> 1677 <211> 939 <212> DNA <213> Canis familiaris <400> 1677

atgagaaacc acacagaaat aacagatttt attctcctgg gattgtcaga tgacccacag 60 cttcaggagg tgatctttgt ctttctgctt atcacctaca tgctcagcat cactgggaac 120 ctgaccatta tcaccctcac cctgctggat tcccacctcc agacccccat gtatttcttc 180 ctcagaaact tctccttact cgagatttca ttcacaactg tgagcatacc caagttcctg 240 agcaccctga ttacaggaga taaaaacatt tcctttaaag attgcatggc tcagttcttt 300 tttctcatct tattgggagt cactgaattt tgccttctgg ctgccatgtc ctatgaccga 360 tacattgcca tctgcaaacc tctgcattac atgaccatca tgaatcccag agtctgcaca 420 ctccttgtct ttgcttcttg gtcggcttca ttcttaatca tattcccatt actcatgctg 480 ttcatacagc ttgattattg taagtccaat gttatagacc attttacctg tgactatttc 540 cccttactac atctttcttg ttcagacact agattcttag agatagtggg tttttcctgt 600 gctgttttta cattaatgtt cacattggca ttaataattc tgtcctacat atatatcctc 660 agaacaattt tgaggattcc ttctactagt cagaggacaa aggccttttc cacctgttct 720 tcccacatga ttgtcatctc catctcctat ggcagctgca ttttcatgta tattaaccca 780 gcagcaaaag acagagtgtc tctgagcaag ggagttgctg tgctaaacac ctcggtagcc 840

Page 1885

069269_0225_SL.TXT cccatgctga acccctttat ttacagccta aggaaccagc aagtcaagcg agccttcctg gacagggcaa ggaagattgt atttttctca agcaaatga

900

939 <210> 1678 <211> 312 <212> PRT <213> Canis familiaris

<400> 1678 Glu Ile Thr Asp Phe Ile Leu Leu Gly Leu Ser Met Arg 1 Asn His Thr 5 10 15 Asp Asp Pro Gln Leu Gln Glu Val Ile Phe Val Phe Leu Leu Ile Thr 20 25 30 Tyr Met Leu Ser Ile Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Leu Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Leu Leu Glu Ile Ser Phe Thr Thr Val Ser Ile Pro Lys Phe Leu 65 70 75 80 Ser Thr Leu Ile Thr Gly Asp Lys Asn Ile Ser Phe Lys Asp Cys Met 85 90 95 Ala Gln Phe Phe Phe Leu Ile Leu Leu Gly Val Thr Glu Phe Cys Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Ile Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Pro Arg Val Cys Thr Leu Leu Val Phe 130 135 140 Ala Ser Trp Ser Ala Ser Phe Leu Ile Ile Phe Pro Leu Leu Met Leu 145 150 155 160

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Phe Ile Gln Leu Asp Tyr Cys Lys Ser Asn 170 Val Ile Asp His Phe 175 Thr 165 Cys Asp Tyr Phe Pro Leu Leu His Leu Ser Cys Ser Asp Thr Arg Phe 180 185 190 Leu Glu Ile Val Gly Phe Ser Cys Ala Val Phe Thr Leu Met Phe Thr 195 200 205 Leu Ala Leu Ile Ile Leu Ser Tyr Ile Tyr Ile Leu Arg Thr Ile Leu 210 215 220 Arg Ile Pro Ser Thr Ser Gln Arg Thr Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Ile Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Asn Pro Ala Ala Lys Asp Arg Val Ser Leu Ser Lys Gly Val 260 265 270 Ala Val Leu Asn Thr Ser Val Ala Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Gln Gln Val Lys Arg Ala Phe Leu Asp Arg Ala Arg 290 295 300 Lys Ile Val Phe Phe Ser Ser Lys 305 310 <210> 1679 <211> 882 <212> DNA <213> Canis familiaris <400> 1679 ccagagtttc agattgtgat ttttctcttt ttaattctca catacatatt cagtgtcact ggaaatttga ccatcatcac tctcaccttg gtggactccc atctacagac ccctatgtat tttttcctca ggaacttctc tgtattagaa atatccttta caaccatctg tattcctaga

120

180

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tttctgggca caattatcac cagagactaa actatttcat acaatgattg tacagctcag 240 ttgtttttct tcatcttcat gggcataact gagttttatc ttctaactgc tatgtcctat 300 gatcgctatg tagccatctg taaacccttg cattacacga ctatcatgaa caaaagagtc 360 tgcattttac ttgtcttttg tgcatggctg gcaggattct taaatatctt cccgccaatt 420 attcttttcc tccagttaga ttactgtggc tccaatgtca ttgatcactt tgcttgtgac 480 tattttcccc tcttgcaatt atcttgctca gacacatggc tcctagaagt gattggtttt 540 tactctgcaa tagtgattct gcttttcact ctggcactaa taattctatc ctacatgttc 600 atcattagaa caattctgaa actgccatct gccagtcaga gaaaaaaggc attttctaca 660 tgctcctcgc acatgattgt catttccatc tcttatggaa gctgcatatt catgtatgcc 720 aacccctctg caaaagaaaa ggcatccttg accaaaggag tagctattct taatacttct 780 gttgctccta tgatgaatcc atttatatat accctgagga atcagcaagt aaagcaagcc 840 tttaaggata ctatccaaaa ggttctgttt ttctccagta aa 882 <210> 1680 <211> 208 <212> PRT <213> Canis familiaris <400> 1680 Met Gly Ile Thr Glu Phe Tyr Leu Leu Thr Ala Met Ser Tyr Asp Arg 1 5 10 15 Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Thr Thr Ile Met Asn Lys 20 25 30 Arg Val Cys Ile Leu Leu Val Phe Cys Ala Trp Leu Ala Gly Phe Leu 35 40 45 Asn Ile Phe Pro Pro Ile Ile Leu Phe Leu Gln Leu Asp Tyr Cys Gly 50 55 60 Ser Asn Val Ile Asp His Phe Ala Cys Asp Tyr Phe Pro Leu Leu Gln 65 70 75 80 Leu Ser Cys Ser Asp Thr Trp Leu Leu Glu Val Ile Gly Phe Tyr Ser

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85 90 95 Ala Ile Val Ile Leu Leu Phe Thr Leu Ala Leu Ile Ile Leu Ser Tyr 100 105 110 Met Phe Ile Ile Arg Thr Ile Leu Lys Leu Pro Ser Ala Ser Gln Arg 115 120 125 Lys Lys Ala Phe Ser Thr Cys Ser Ser His Met Ile Val Ile Ser Ile 130 135 140 Ser Tyr Gly Ser Cys Ile Phe Met Tyr Ala Asn Pro Ser Ala Lys Glu 145 150 155 160 Lys Ala Ser Leu Thr Lys Gly Val Ala Ile Leu Asn Thr Ser Val Ala 165 170 175 Pro Met Met Asn Pro Phe Ile Tyr Thr Leu Arg Asn Gln Gln Val Lys 180 185 190 Gln Ala Phe Lys Asp Thr Ile Gln Lys Val Leu Phe Phe Ser Ser Lys 195 200 205

<210> 1681 <211> 933 <212> DNA <213> Canis familiaris <400> 1681

atgaataata gaacatcagt gaccaacttc atcctcctgg gtctgaccga caatccagaa 60 atacaggctg taaatttcct ctttctattt ctcacctacg tactgagtgt tactggaaat 120 ctcaccatca tcattcttac cctgctggat tcccacctgg aggctcccat gtattttttc 180 ctccgatttt ttcctccgaa tttctcctta gaaatttcat tcacttctgt ctgtaatcct 240 agatttttca tcagcatcgt aactggagac aaatctattt cctataatgc ttgtgcagct 300 cagctatttt tctttgtcct ccttggctaa ccagtttttc ttctggctgc tatgtcctat 360 gatcattatg cggctatctg caagcttcta cattatacaa ccaccatgag taacaagatt 420 tgctaccagc ttgtagtcag ctcttgggtg gctggtttct tggtaatctt cccaccacta 480

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gccatgggtc tgcagttgga tttctgtgac tccaatgtca ttgaccactt cacctatgat 540 tctgctcctt tactccaaat gtcttgcaca gacacaagta ctctagagct catgagcttt 600 gttttagcca tacttactct tatgtccact ttgatgttag taattctctc ccactcttac 660 atccttagaa caattctgaa aatcccttca gctcaacaaa gaaaaaaggc cttctcaacc 720 tgctcctccc atatgatagt tgtctctatc tcttatggga gctgcatctt catgtatgtc 780 aaaacatcag caaaggaagg ggttgctttg acaaaaggtg tggctatgct cagtacctct 840 gttgctctca tgctgaatcc atttatttac actttaagga accagcaggt gaaagaagca 900 tttaaggacg ttgtgaaaaa gatacttttc tca 933

<210> 1682 <211> 194 <212> PRT <213> Canis familiaris

<400> 1682 Met Ser Tyr 1 Asp His Tyr Ala Ala Ile Cys Lys Leu Leu His Tyr 15 Thr 5 10 Thr Thr Met Ser Asn Lys Ile Cys Tyr Gln Leu Val Val Ser Ser Trp 20 25 30 Val Ala Gly Phe Leu Val Ile Phe Pro Pro Leu Ala Met Gly Leu Gln 35 40 45 Leu Asp Phe Cys Asp Ser Asn Val Ile Asp His Phe Thr Tyr Asp Ser 50 55 60 Ala Pro Leu Leu Gln Met Ser Cys Thr Asp Thr Ser Thr Leu Glu Leu 65 70 75 80 Met Ser Phe Val Leu Ala Ile Leu Thr Leu Met Ser Thr Leu Met Leu 85 90 95 Val Ile Leu Ser His Ser Tyr Ile Leu Arg Thr Ile Leu Lys Ile Pro 100 105 110

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Ser Ala Gln 115 Gln Arg Lys Lys 069269_0225_SL.TXT Ala Phe Ser Thr Cys Ser 120 125 Ser His Met Ile Val Val Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met Tyr Val Lys 130 135 140 Thr Ser Ala Lys Glu Gly Val Ala Leu Thr Lys Gly Val Ala Met Leu 145 150 155 160 Ser Thr Ser Val Ala Leu Met Leu Asn Pro Phe Ile Tyr Thr Leu Arg 165 170 175 Asn Gln Gln Val Lys Glu Ala Phe Lys Asp Val Val Lys Lys Ile Leu 180 185 190

Phe Ser <210> 1683 <211> 972 <212> DNA <213> Canis familiaris <400> 1683

atggttagat ttcaaaagtc agtgatgaga aactatacag caataacaac ttttatcctg 60 ctgggactga cagacgaccc acaactgcaa atcctgctct ttatctttct atttctcacc 120 tacatcttga gcgtaacagg gaaccggact attatcaccc tcactctggt gaactcccat 180 cttaaaactc ctatgtactt ttttctgaga aatgtttcct tcttagaagt gtcattcacc 240 actgtctgca ttcctagatt cctgtatagc atatcaacag gggccaatac tattacctac 300 aatgcttgtg caagtcaaat atcttttgtt attctctttg gagcaactga attttttctc 360 ctggcagcca tgtcctatga tcgctatgtt gctatctgta aaccacttca ttacatgacc 420 atcatgagca atagggtgtg tagcttatta gtcttctgct gttgggtgtc tggcttgatg 480 atcattctcc caccccttag cttgtgcctc cagctggaat tctgtgactc gaatgccatc 540 gatcatttta gctgtgatgc aggtcccctc ctgaagatct catgttcaga tacatggatg 600 atagaacaaa tggttatcct tgtggctgta tttgcactca ttatcacctt agtgtgtgta 660

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tttctgtcct acacatacat catcaggaca attctgagat tcccctctgt ccaacaaaga 720 aaaaaggcct tttccacctg ctcatcccac atgattgtag tttccatcac ctatggaagc 780 ggcatcttca tctatatcaa gtcatcagca aaagaagaga tagccataaa taaaggtgtt 840 tcggtgctca ctacttctgt tgcacccttg ctgaacccct tcttttacac cttgagaaat 900 aagcaagtga aacaagcttt taatgacttc ataaagaaga tgacatttca ctcaaagaaa 960 ctgaagtttt ga 972

<210> 1684 <211> 323 <212> PRT <213> Canis familiaris <400> 1684

Met 1 Val Arg Phe Gln Lys Ser Val Met Arg Asn Tyr Thr Ala Ile Thr 5 10 15 Thr Phe Ile Leu Leu Gly Leu Thr Asp Asp Pro Gln Leu Gln Ile Leu 20 25 30 Leu Phe Ile Phe Leu Phe Leu Thr Tyr Ile Leu Ser Val Thr Gly Asn 35 40 45 Arg Thr Ile Ile Thr Leu Thr Leu Val Asn Ser His Leu Lys Thr Pro 50 55 60 Met Tyr Phe Phe Leu Arg Asn Val Ser Phe Leu Glu Val Ser Phe Thr 65 70 75 80 Thr Val Cys Ile Pro Arg Phe Leu Tyr Ser Ile Ser Thr Gly Ala Asn 85 90 95 Thr Ile Thr Tyr Asn Ala Cys Ala Ser Gln Ile Ser Phe Val Ile Leu 100 105 110 Phe Gly Ala Thr Glu Phe Phe Leu Leu Ala Ala Met Ser Tyr Asp Arg 115 120 125 Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Ile Met Ser Asn

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130 135 140

Arg 145 Val Cys Ser Leu Leu Val Phe Cys Cys Trp Val Ser Gly Leu Met 150 155 160 Ile Ile Leu Pro Pro Leu Ser Leu Cys Leu Gln Leu Glu Phe Cys Asp 165 170 175 Ser Asn Ala Ile Asp His Phe Ser Cys Asp Ala Gly Pro Leu Leu Lys 180 185 190 Ile Ser Cys Ser Asp Thr Trp Met Ile Glu Gln Met Val Ile Leu Val 195 200 205 Ala Val Phe Ala Leu Ile Ile Thr Leu Val Cys Val Phe Leu Ser Tyr 210 215 220 Thr Tyr Ile Ile Arg Thr Ile Leu Arg Phe Pro Ser Val Gln Gln Arg 225 230 235 240 Lys Lys Ala Phe Ser Thr Cys Ser Ser His Met Ile Val Val Ser Ile 245 250 255 Thr Tyr Gly Ser Gly Ile Phe Ile Tyr Ile Lys Ser Ser Ala Lys Glu 260 265 270 Glu Ile Ala Ile Asn Lys Gly Val Ser Val Leu Thr Thr Ser Val Ala 275 280 285 Pro Leu Leu Asn Pro Phe Phe Tyr Thr Leu Arg Asn Lys Gln Val Lys 290 295 300 Gln Ala Phe Asn Asp Phe Ile Lys Lys Met Thr Phe His Ser Lys Lys 305 310 315 320 Leu Lys Phe <210> 1685

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069269_0225_SL.TXT <211> 939 <212> DNA <213> Canis familiaris <400> 1685

atgagaaatc acacagcaat aacaacattc atcttgttgg gacttacaga ggacccacag 60 ctgcaagttc ttctttttat cttcttattt ctcagctacg tgctgagcat tactggaaat 120 ttgaccatta tcattcttac atttatggat tctcatctta aaacacctat gtattttttt 180 ctccgcaatt tctccatctt agaaatctca ttcacaacag tatgcattcc cagattcttg 240 tacagtataa caactggaga caacactatt acgtataatg cttgcgcttg ccaaatattt 300 tttattgggc tttttggggt cacagaattt tttctcctgg cagccatgtc ctatgaccgc 360 tatgtggcca tctgcaaacc ccttcattac atgaccatca tgaataacaa agtctgtacc 420 atccttgtcc tctgttgctg gatttctggg ctgctgatca tcatcacacc ccttggtatg 480 ggcctccagc tggaattctg tgactccaat gccattgatc attttggctg tgatgcatct 540 cctcttttta agatttcatg ctcggataca tgggttatag aacaggtggt tataatctgt 600 gcagtactga cattcattat tacactgata ggtgtcattc tttcctatat atatatcatc 660 aggacaattc taagattttc ttctgcttct caaagaaaaa aagctttctc cacctgttct 720 tcacacatgc ttgttgtttc cattacatac ggcagctgta ttttcatcta tatcaagcct 780 tcggccaaag aagaggtgga tatcaataaa ggggtatccg tgctcactac atctgttgct 840 cctttgttga accctttcat ttatactttg aggaacaagc aagtgaaacg agctttcaat 900 gacacaatca aaaaaattgc atttatctta cacaaataa 939

<210> 1686 <211> 312 <212> PRT <213> Canis familiaris

<400> 1686 Met Arg Asn His Thr Ala Ile Thr Thr Phe Ile Leu Leu Gly Leu Thr 1 5 10 15

Glu Asp Pro Gln Leu Gln Val Leu Leu Phe Ile Phe Leu Phe Leu Ser 20 25 30

Page 1894

Tyr Val Leu 35 Ser Ile Thr Gly 069269_0225_SL.TXT Asn Leu Thr Ile Ile Ile 40 45 Leu Thr Phe Met Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Ile Leu Glu Ile Ser Phe Thr Thr Val Cys Ile Pro Arg Phe Leu 65 70 75 80 Tyr Ser Ile Thr Thr Gly Asp Asn Thr Ile Thr Tyr Asn Ala Cys Ala 85 90 95 Cys Gln Ile Phe Phe Ile Gly Leu Phe Gly Val Thr Glu Phe Phe Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Asn Lys Val Cys Thr Ile Leu Val Leu 130 135 140 Cys Cys Trp Ile Ser Gly Leu Leu Ile Ile Ile Thr Pro Leu Gly Met 145 150 155 160 Gly Leu Gln Leu Glu Phe Cys Asp Ser Asn Ala Ile Asp His Phe Gly 165 170 175 Cys Asp Ala Ser Pro Leu Phe Lys Ile Ser Cys Ser Asp Thr Trp Val 180 185 190 Ile Glu Gln Val Val Ile Ile Cys Ala Val Leu Thr Phe Ile Ile Thr 195 200 205 Leu Ile Gly Val Ile Leu Ser Tyr Ile Tyr Ile Ile Arg Thr Ile Leu 210 215 220 Arg Phe Ser Ser Ala Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240

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Ser His Met Leu Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe 255 Ile 245 250 Tyr Ile Lys Pro Ser Ala Lys Glu Glu Val Asp Ile Asn Lys Gly Val 260 265 270 Ser Val Leu Thr Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Lys Arg Ala Phe Asn Asp Thr Ile Lys 290 295 300 Lys Ile Ala Phe Ile Leu His Lys 305 310

<210> 1687 <211> 963 <212> DNA <213> Canis familiaris <400> 1687

atgagaaacc aaacagcact aacaactttc atcttgctgg gactcaccga ggaccctcaa 60 ctaaaaattt tgctttttat gtttctgttt ctttcctaca tgttgaatgt atctggaaac 120 ctaaccatca tcatcctcac tctgattgat tcccacctta aaacaccaat gtatcttttc 180 ctccaaaatt tctccttcct agaaatttca ttcacaactt cttgtgtccc cagattttta 240 tatagcatat catcggggga caaatccatt acctataatg cttgtgtcag tcaactgttg 300 tttacagacc tctttgcagt aacagaattt tttctctttg ctactatgtc ctatgatcgc 360 tatgtggcca tctgcaaacc cctgcattac atgaccatca tgagcagaag agtctgcaag 420 aacttcatcg tcttctgttg ggtagcagca ctgatcatca ttctcccacc aattagtcta 480 gttttgggcc tggaattctg tgattcaaac atcattgatc atttttgttg tgatgcatct 540 cctatcctga agatctcttg ctcagacaca tggttgatag aacagatggt tatagtctgt 600 gctgtgttga cattcatcat caccctcatg tgtgtagttc tttcttacat ttatattata 660 gggaccattc taaggtttcc ctttgctcag caaaggaaaa aggccttttc cacttgttct 720 tcccacatga ttgttgtttc cattacttat ggtagctgta tcttcattta tgtcaaacct 780

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tcagccaagg atgaggtagc tattaataaa gggatttcac tccttattac ttctatctca 840 ccaatgttga atccctttat ttacacactg agaaacaagc aagtgaagaa agcttttcat 900 gattcaatta aaaaattgca ttcctatcaa agatgtaaag gagaaatgag tcaattaatc 960 taa 963

<210> 1688 <211> 320 <212> PRT <213> Canis familiaris

<400> 1688 Met Arg Asn 1 Gln Thr Ala Leu Thr Thr Phe Ile Leu Leu Gly Leu 15 Thr 5 10 Glu Asp Pro Gln Leu Lys Ile Leu Leu Phe Met Phe Leu Phe Leu Ser 20 25 30 Tyr Met Leu Asn Val Ser Gly Asn Leu Thr Ile Ile Ile Leu Thr Leu 35 40 45 Ile Asp Ser His Leu Lys Thr Pro Met Tyr Leu Phe Leu Gln Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Phe Thr Thr Ser Cys Val Pro Arg Phe Leu 65 70 75 80 Tyr Ser Ile Ser Ser Gly Asp Lys Ser Ile Thr Tyr Asn Ala Cys Val 85 90 95 Ser Gln Leu Leu Phe Thr Asp Leu Phe Ala Val Thr Glu Phe Phe Leu 100 105 110 Phe Ala Thr Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Ser Arg Arg Val Cys Lys Asn Phe Ile Val 130 135 140 Phe Cys Trp Val Ala Ala Leu Ile Ile Ile Leu Pro Pro Ile Ser Leu

Page 1897

0 6926 9_02 25_S L.TX T 145 150 155 160 Val Leu Gly Leu Glu Phe Cys Asp Ser Asn Ile Ile Asp His Phe Cys 165 170 175 Cys Asp Ala Ser Pro Ile Leu Lys Ile Ser Cys Ser Asp Thr Trp Leu 180 185 190 Ile Glu Gln Met Val Ile Val Cys Ala Val Leu Thr Phe Ile Ile Thr 195 200 205 Leu Met Cys Val Val Leu Ser Tyr Ile Tyr Ile Ile Gly Thr Ile Leu 210 215 220 Arg Phe Pro Phe Ala Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile 245 250 255 Tyr Val Lys Pro Ser Ala Lys Asp Glu Val Ala Ile Asn Lys Gly Ile 260 265 270 Ser Leu Leu Ile Thr Ser Ile Ser Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Lys Lys Ala Phe His Asp Ser Ile Lys 290 295 300 Lys Leu His Ser Tyr Gln Arg Cys Lys Gly Glu Met Ser Gln Leu Ile 305 310 315 320

<210> 1689 <211> 936 <212> DNA <213> Canis familiaris <400> 1689 atgagaaacg gtacaataac aacattcatt ctgctgggac tgacagatga ccctgagctg caagttctga tttttatctt tctatttctc acctacactt tgagtataac tggaaacctg

120

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gccatcatca tactcacttt tgtggatccc caccttaaaa cacccatgta ctttttctta 180 aaaaatttct ccttcttgga gatctcattc acatctgcca ttattcccag atatttgtat 240 agcatagcaa caggtgacaa tgttattacc tataatgctt gtgtcattca agtgtttttt 300 actgacctct gtggagtatc agagtttttt ctgctggccg ccatgtccta tgaccgctat 360 gttgccatct gcaaaccctt gcattatgtg atcataatga gtaacagcgt ctgcaggatt 420 ctcaatatct gttgttgggt ggctggttta tgtatcataa tcccaccact tagcctgggt 480 ttaaatctaa aattttgtga ctctaacata attgatcatt ttggctgtga tgcatttccc 540 ttagtgaaaa tctcatgttc agatacaagg ttcatggaat ggacagttat aatatgtgcc 600 atagtgacct tgaatatgac tcttacctgt gtggttctgt catatgctta catcatcaag 660 acaattttta gattcccttc tgttcaacaa aggaaaaagg ccttttcgac gtgttcttcc 720 cacatgattg tggtatccat cacctatggc acatgcattt tcatctatat gaatcctaca 780 gcaaaggaaa aagtgaccat taataaagtg gtttcactgc tcatttcttc tatttcacct 840 acattgaacc catttattta taccttgaga aacaatcaag ttaagaaagc cttcgaggac 900 tcaatcaaaa gaattgcctt gctctcaact aagtaa 936

<210> 1690 <211> 311 <212> PRT <213> Canis familiaris

<400> 1690 Ile Thr Thr Phe Ile Leu Leu Gly Leu Thr Asp Met 1 Arg Asn Gly Thr 5 10 15 Asp Pro Glu Leu Gln Val Leu Ile Phe Ile Phe Leu Phe Leu Thr Tyr 20 25 30 Thr Leu Ser Ile Thr Gly Asn Leu Ala Ile Ile Ile Leu Thr Phe Val 35 40 45 Asp Pro His Leu Lys Thr Pro Met Tyr Phe Phe Leu Lys Asn Phe Ser 50 55 60

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Phe 65 Leu Glu Ile Ser Phe 70 Thr Ser Ala Ile Ile Pro Arg 75 Tyr Leu Tyr 80 Ser Ile Ala Thr Gly Asp Asn Val Ile Thr Tyr Asn Ala Cys Val Ile 85 90 95 Gln Val Phe Phe Thr Asp Leu Cys Gly Val Ser Glu Phe Phe Leu Leu 100 105 110 Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His 115 120 125 Tyr Val Ile Ile Met Ser Asn Ser Val Cys Arg Ile Leu Asn Ile Cys 130 135 140 Cys Trp Val Ala Gly Leu Cys Ile Ile Ile Pro Pro Leu Ser Leu Gly 145 150 155 160 Leu Asn Leu Lys Phe Cys Asp Ser Asn Ile Ile Asp His Phe Gly Cys 165 170 175 Asp Ala Phe Pro Leu Val Lys Ile Ser Cys Ser Asp Thr Arg Phe Met 180 185 190 Glu Trp Thr Val Ile Ile Cys Ala Ile Val Thr Leu Asn Met Thr Leu 195 200 205 Thr Cys Val Val Leu Ser Tyr Ala Tyr Ile Ile Lys Thr Ile Phe Arg 210 215 220 Phe Pro Ser Val Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Met Ile Val Val Ser Ile Thr Tyr Gly Thr Cys Ile Phe Ile Tyr 245 250 255 Met Asn Pro Thr Ala Lys Glu Lys Val Thr Ile Asn Lys Val Val Ser 260 265 270

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Leu Leu Ile Ser Ser Ile Ser Pro Thr Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Asn Gln Val Lys Lys Ala Phe Glu Asp Ser Ile Lys Arg 290 295 300 Ile Ala Leu Leu Ser Thr Lys 305 310

<210> 1691 <211> 960 <212> DNA <213> Canis familiaris <400> 1691

atggaggagt tcaaccattc tagagtgtct gaatttgtgt tacttggact tacggattct 60 cctgagctcc agattttttt ctttgtgata ttttctgttt tctatttgat aactatgttg 120 ggcaactgtc ttattttgct cacagttcta tccaccccac accttcactc ccctatgtat 180 ttcctcctca gcaacctgtc tctcattgac atatgcctgt cctcctttgc cactccaaag 240 atgatcatgg acttctttgc taaacataag accatctcct ttgagggctg tatttctcag 300 atcttctttt tgcacctctt cactgggact gagattgtac tattgatctc catgtctttt 360 gacaggtaca ttgccatatg taaacctctc cattattcaa caattatgaa ccaaagagtg 420 tgtgttgggc ttgtggtaac ttcttggaca gtgggcttcc tgcatacaac aagccagtta 480 gcttttaccc tctatttacc cttctgtggt cccaatgttg tagacagttt cttctgtgac 540 cttcctttgg tcatccagct cgcttgtata gatatatatg ttcttggaat cttcatgatc 600 tcaaccagtg gtgtgattgc tcttgtaagt tttctgcttt tgctcacctc ctatatcatt 660 gtgcttgtca ctattaagga ccgctccttt acaggaacat ctaaggcttt ttctacctgc 720 actgcacatt tcatagttgt gttaatgttc tttgggcctt gtatctttat ttatgtgtgg 780 cctttcacca acttcctgat ggacaaagtt ctgtccgttt tctataccat tttcaccccc 840 tttctgaatc cacttatcta tactttgaga aatcaggaag tgaagatagc tgtgaagaag 900 aaactaacta atcaaagctt aaatcttggg aaaactagtc caaattaccc agtgcagtga 960

<210> 1692

Page 1901

069269_0225_SL.TXT <211> 319 <212> PRT <213> Canis familiaris

<400> 1692 Leu 15 Gly Met 1 Glu Glu Phe Asn His Ser Arg 5 Val Ser 10 Glu Phe Val Leu Leu Thr Asp Ser Pro Glu Leu Gln Ile Phe Phe Phe Val Ile Phe Ser 20 25 30 Val Phe Tyr Leu Ile Thr Met Leu Gly Asn Cys Leu Ile Leu Leu Thr 35 40 45 Val Leu Ser Thr Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ser 50 55 60 Asn Leu Ser Leu Ile Asp Ile Cys Leu Ser Ser Phe Ala Thr Pro Lys 65 70 75 80 Met Ile Met Asp Phe Phe Ala Lys His Lys Thr Ile Ser Phe Glu Gly 85 90 95 Cys Ile Ser Gln Ile Phe Phe Leu His Leu Phe Thr Gly Thr Glu Ile 100 105 110 Val Leu Leu Ile Ser Met Ser Phe Asp Arg Tyr Ile Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Ile Met Asn Gln Arg Val Cys Val Gly Leu 130 135 140 Val Val Thr Ser Trp Thr Val Gly Phe Leu His Thr Thr Ser Gln Leu 145 150 155 160 Ala Phe Thr Leu Tyr Leu Pro Phe Cys Gly Pro Asn Val Val Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Leu Val Ile Gln Leu Ala Cys Ile Asp Ile 180 185 190

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Tyr Val Leu 195 Gly Ile Phe Met Ile Ser Thr Ser Gly Val Ile Ala Leu 200 205 Val Ser Phe Leu Leu Leu Leu Thr Ser Tyr Ile Ile Val Leu Val Thr 210 215 220 Ile Lys Asp Arg Ser Phe Thr Gly Thr Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 Thr Ala His Phe Ile Val Val Leu Met Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Val Trp Pro Phe Thr Asn Phe Leu Met Asp Lys Val Leu Ser 260 265 270 Val Phe Tyr Thr Ile Phe Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Ile Ala Val Lys Lys Lys Leu Thr Asn 290 295 300 Gln Ser Leu Asn Leu Gly Lys Thr Ser Pro Asn Tyr Pro Val Gln 305 310 315

<210> 1693 <211> 273 <212> DNA <213> Canis familiaris <400> 1693 atggatggag caaatcactc tgtggtgtca gagtttgtgt tcctgggact caccaactcc 60 tgggagatcc agcttctcct ctttgtgttt tcctccacgt tttatatggc aagcatgatg 120 ggaaactccc tcatcatgct cactgtgact tctgaccctc acctgcactc ccccatgtac 180 tttctgttgg ccaacctctc cttcattgac ctgggagttt cttcagtcac ttctcccaag 240 atgatttatg atctttcaga aaagatacaa att 273 <210> 1694 <211> 91

Page 1903

069269_0225_SL.TXT <212> PRT <213> Canis familiaris

<400> 1694 Ala Asn His Ser Val Val Ser Glu Phe Val Phe Leu Gly Met Asp 1 Gly 5 10 15 Leu Thr Asn Ser Trp Glu Ile Gln Leu Leu Leu Phe Val Phe Ser Ser 20 25 30 Thr Phe Tyr Met Ala Ser Met Met Gly Asn Ser Leu Ile Met Leu Thr 35 40 45 Val Thr Ser Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ala

50 55 60

Asn Leu Ser Phe Ile Asp Leu Gly Val Ser Ser Val Thr Ser Pro Lys

65 70 75 80 Met Ile Tyr Asp Leu Ser Glu Lys Ile Gln Ile 85 90

<210> 1695 <211> 429 <212> DNA <213> Canis familiaris <400> 1695 cccttctgtg gtcctaatgt gctggacagc ttttactgtg accttccttg gttcatcaga 60 cttgcctgca cagagactta ccgactagag tttatggtca tagccaatag tggagttggc 120 tccttcttca tactgatcat ttcctatatc atcatcattc tctctgttca gaaacactct 180 tcagctggtt catccaagtc tctgtccaca ctgtcagctc acatcactgt ggtattcttg 240 ttctttagtc ctttgatatt tgtctatatg tggccatttc cctccataca cctggataaa 300 tttctggcca tctttgatgc tgttctcact ccctttctga atccagtcat ctatacattc 360 aggaatcaag aaatgaaggt ggcaatgagg agagtatgca gacagctagt gaattacagg 420 aagatctct 429 <210> 1696

Page 1904

069269_0225_SL.TXT <211> 143 <212> PRT <213> Canis familiaris

<400> 1696 Gly Pro 5 Asn Val Leu Asp Ser Phe Tyr Cys Asp Leu Pro Pro 1 Phe Cys 10 15 Trp Phe Ile Arg Leu Ala Cys Thr Glu Thr Tyr Arg Leu Glu Phe Met 20 25 30 Val Ile Ala Asn Ser Gly Val Gly Ser Phe Phe Ile Leu Ile Ile Ser 35 40 45 Tyr Ile Ile Ile Ile Leu Ser Val Gln Lys His Ser Ser Ala Gly Ser 50 55 60 Ser Lys Ser Leu Ser Thr Leu Ser Ala His Ile Thr Val Val Phe Leu 65 70 75 80 Phe Phe Ser Pro Leu Ile Phe Val Tyr Met Trp Pro Phe Pro Ser Ile 85 90 95 His Leu Asp Lys Phe Leu Ala Ile Phe Asp Ala Val Leu Thr Pro Phe 100 105 110 Leu Asn Pro Val Ile Tyr Thr Phe Arg Asn Gln Glu Met Lys Val Ala 115 120 125 Met Arg Arg Val Cys Arg Gln Leu Val Asn Tyr Arg Lys Ile Ser 130 135 140

<210> 1697 <211> 939 <212> DNA <213> Canis familiaris <400> 1697 atgggtggag cgaatcactc tgtggtgtca gagtttgtgt tcctgggact caccaactcc tgggagatcc agcttctcct ctttgtgttc tcctccatgt tttatgtggc aagcatgatg ggaaactccc tcatcatgct cactgtgact tttgaccctc acctgcactc tcccatgtac Page 1905

120

180

069269_0225_SL.TXT

tttctgttgg ccaacctctc cttcattgac ctgggagttt cttcagtcat ttctcctaag 240 atgatttacg accttttcag aaaacgtaaa gtcatctcct ttggtggttg catcactcag 300 atcttctttc tccatgtcat tggtggtgtg gagatgatgc tgctcatcgc catggccttt 360 gacagacatg tggccatatg taagcctctc cactatttga ccattattaa ccgaaaaatg 420 tgtattttgc ttctggttgc tgcttgggta gttggcttgg cccactctat gattcaactg 480 gtttttgtta taaaattgcc attctgtggc cctaatgtgc tggacagctt ttactgtgac 540 ttccctcggt tcatcaaact tgcctgcaca gatactttca gtctagagtt catggtcaca 600 gccaacagtg gttttatatc tctggggtca ttcttcatat tgattgtctc ctatagtttt 660 atcctgatca ctgttaggaa acactcctca agaggctcat ccaaggccct ctccactttg 720 tcagctcata tcatggtggt gattttgttc tttggtcctt gcatctttgt ttatatctgg 780 cctcacccca catcatgctt agacaaattt cttgctgttt ttgatgcagt tcttactccc 840 ttttttaatt cagtcatcta tacattaagg aacaaagaaa tgaaagtggc aatgagtaaa 900 atatgcagtc aatttattat ttatagaagg atttcttaa 939

<210> 1698 <211> 312 <212> PRT <213> Canis familiaris

<400> 1698 Met Gly Gly Ala 1 Asn 5 His Ser Val Val Ser Glu Phe Val Phe Leu Gly 10 15 Leu Thr Asn Ser Trp Glu Ile Gln Leu Leu Leu Phe Val Phe Ser Ser 20 25 30 Met Phe Tyr Val Ala Ser Met Met Gly Asn Ser Leu Ile Met Leu Thr 35 40 45 Val Thr Phe Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Phe Ile Asp Leu Gly Val Ser Ser Val Ile Ser Pro Lys 65 70 75 80

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Met Ile Tyr Asp Leu 85 Phe Arg Lys Arg Lys Val Ile Ser Phe Gly Gly 90 95 Cys Ile Thr Gln Ile Phe Phe Leu His Val Ile Gly Gly Val Glu Met 100 105 110 Met Leu Leu Ile Ala Met Ala Phe Asp Arg His Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Thr Ile Ile Asn Arg Lys Met Cys Ile Leu Leu 130 135 140 Leu Val Ala Ala Trp Val Val Gly Leu Ala His Ser Met Ile Gln Leu 145 150 155 160 Val Phe Val Ile Lys Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Ser 165 170 175 Phe Tyr Cys Asp Phe Pro Arg Phe Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Ser Leu Glu Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Leu 195 200 205 Gly Ser Phe Phe Ile Leu Ile Val Ser Tyr Ser Phe Ile Leu Ile Thr 210 215 220 Val Arg Lys His Ser Ser Arg Gly Ser Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Ile Met Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Val Tyr Ile Trp Pro His Pro Thr Ser Cys Leu Asp Lys Phe Leu Ala 260 265 270 Val Phe Asp Ala Val Leu Thr Pro Phe Phe Asn Ser Val Ile Tyr Thr 275 280 285

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069269_0225_SL.TXT

Leu Arg Asn Lys Glu Met Lys Val Ala Met Ser Lys Ile Cys Ser Gln 290 295 300

Phe Ile Ile Tyr Arg Arg Ile Ser

305 310 <210> 1699 <211> 936 <212> DNA <213> Canis familiaris <400> 1699

atggatggag ggaatcactc ggctgtgtct gagtttgtgt tcctgggact cactcactca 60 tgggagatcc agcttctcct tctggtgttc tcctctgtgc tctacgtggc aagcatgact 120 ggaaacatcc tcattgtgtt ttctgtgacc attgatcctc acttacactc ccccatgtac 180 tttctcctgg ccagtctctc tttcactgac ttgggagcct gctctgctac ctcacccaag 240 atgatttatg accttttcag aaagcacaaa gtcatcccct ttggcggctg catcgcccag 300 atcttcttca tccatgtcat tggtggcgtg gaaatggtgc tgctcattgc catggccttt 360 gacagatatg tggccacatg caagcccctc cactatctga ccatcatgag cccacagagg 420 tgcatcttat ttctggctgc tgcttgggcc cttggtgtca gtcactcact gttccaactg 480 gcatttgttg ttaatctacc cttctgtggt cctaatgtgc tggacagctt ttactgtgac 540 cttcctcgtc tcctcagact ggcctgtaca gacacctaca ggttgcagtt catggtcact 600 gtcaacagtg ggtttatctg tgttggttcc ttcttcatac tcctcatctc ctacgtcttc 660 atcctgttta ctgtttggaa acattcctca ggtggctcat ccaaggccct ctccactttg 720 tcagctcaca tcactgtggt aatttttttc tttggtccaa ccatgtttgt ctatacatgg 780 ctacacccca attcccagat ggacagattt cttgctctct ctgatgcagt tctcactcct 840 tttttaaatc ctgttatcta cacattcagg aataaagtga tgaaggcagc aatgaaaaga 900 gctttcagac cattaatgat ttttagaaag atttca 936

<210> 1700 <211> 312 <212> PRT

Page 1908

069269_0225_SL.TXT <213> Canis familiaris <400> 1700

Met Asp Gly Gly Asn His Ser Ala Val Ser Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Thr His Ser Trp Glu Ile Gln Leu Leu Leu Leu Val Phe Ser Ser 20 25 30 Val Leu Tyr Val Ala Ser Met Thr Gly Asn Ile Leu Ile Val Phe Ser 35 40 45 Val Thr Ile Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Ser Leu Ser Phe Thr Asp Leu Gly Ala Cys Ser Ala Thr Ser Pro Lys 65 70 75 80 Met Ile Tyr Asp Leu Phe Arg Lys His Lys Val Ile Pro Phe Gly Gly 85 90 95 Cys Ile Ala Gln Ile Phe Phe Ile His Val Ile Gly Gly Val Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Thr Cys Lys 115 120 125 Pro Leu His Tyr Leu Thr Ile Met Ser Pro Gln Arg Cys Ile Leu Phe 130 135 140 Leu Ala Ala Ala Trp Ala Leu Gly Val Ser His Ser Leu Phe Gln Leu 145 150 155 160 Ala Phe Val Val Asn Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Ser 165 170 175 Phe Tyr Cys Asp Leu Pro Arg Leu Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 Tyr Arg Leu Gln Phe Met Val Thr Val Asn Ser Gly Phe Ile Cys Val

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195 200 205 Gly Ser Phe Phe Ile Leu Leu Ile Ser Tyr Val Phe Ile Leu Phe Thr 210 215 220 Val Trp Lys His Ser Ser Gly Gly Ser Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Ile Phe Phe Phe Gly Pro Thr Met Phe 245 250 255 Val Tyr Thr Trp Leu His Pro Asn Ser Gln Met Asp Arg Phe Leu Ala 260 265 270 Leu Ser Asp Ala Val Leu Thr Pro Phe Leu Asn Pro Val Ile Tyr Thr 275 280 285 Phe Arg Asn Lys Val Met Lys Ala Ala Met Lys Arg Ala Phe Arg Pro 290 295 300 Leu Met Ile Phe Arg Lys Ile Ser

305 310 <210> 1701 <211> 939 <212> DNA <213> Canis familiaris <400> 1701

atggatggag ggaatcactc ggctgtatct gagtttgtgt tcctgggact cactcactca 60 tgggagatcc agcttctcct tctggtgttc tcctctgtgc tctacgtggc aagcatgact 120 ggaaacatcc tcattgtgtt ttctgtgacc attgatcctc acttacactc ccccatgtac 180 tttctcctgg ccagtctctc tttcattgac ttgggagcct gctctgctac ctcacccaag 240 atgatttatg accttttcag aaagcacaaa gtcatctcct ttggcggctg catcgcccag 300 atcttcttca tccatgtcat tggtggcgtg gagatggtgc tgctcattgc catggccttt 360 gacagatatg tggccatatg caagcccctc cattatctga ccatcatgag cccacggagg 420 tgcatcttat ttctggctgc tgcttgggcc cttggtgtca gtcactcact gttccaactg 480

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069269_0225_SL.TXT

gcatttgttg ttaatctacc cttctgtggt cctaatgtgc tggacagctt ttactgtgac 540 cttcctcgtc tcctcagact ggcctgtaca gacacctaca ggttgcagtt catggtcact 600 gtcaacagtg ggtttatctg tgttggttcc ttcttcatac tcctcatctc ctacgtcttc 660 atcctgttta ctgtttggaa acattcctca ggtggctcat ccaaggccct ctccactttg 720 tcagctcaca tcatggtggt ccttttgttc tttggtccaa ccatgtttgt ctatacatgg 780 ccacacccca aatcccagat ggacaaattt cttgctattt ttgatgcagt tctcactcct 840 tttttaaatc ctgttatcta cacattcagg aataaagaca tgaagtcagc aatgaaaaga 900 gtatgcagac agctagtgat ttacaggaag atctcatag 939

<210> 1702 <211> 312 <212> PRT <213> Canis familiaris <400> 1702

Met Asp Gly Gly Asn His Ser Ala Val Ser Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Thr His Ser Trp Glu Ile Gln Leu Leu Leu Leu Val Phe Ser Ser 20 25 30 Val Leu Tyr Val Ala Ser Met Thr Gly Asn Ile Leu Ile Val Phe Ser 35 40 45 Val Thr Ile Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Ser Leu Ser Phe Ile Asp Leu Gly Ala Cys Ser Ala Thr Ser Pro Lys 65 70 75 80 Met Ile Tyr Asp Leu Phe Arg Lys His Lys Val Ile Ser Phe Gly Gly 85 90 95 Cys Ile Ala Gln Ile Phe Phe Ile His Val Ile Gly Gly Val Glu Met 100 105 110

Page 1911

Val Leu Leu 115 Ile Ala Met Ala 069269_0225_SL.TXT Phe Asp Arg Tyr Val Ala 120 125 Ile Cys Lys Pro Leu His Tyr Leu Thr Ile Met Ser Pro Arg Arg Cys Ile Leu Phe 130 135 140 Leu Ala Ala Ala Trp Ala Leu Gly Val Ser His Ser Leu Phe Gln Leu 145 150 155 160 Ala Phe Val Val Asn Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Ser 165 170 175 Phe Tyr Cys Asp Leu Pro Arg Leu Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 Tyr Arg Leu Gln Phe Met Val Thr Val Asn Ser Gly Phe Ile Cys Val 195 200 205 Gly Ser Phe Phe Ile Leu Leu Ile Ser Tyr Val Phe Ile Leu Phe Thr 210 215 220 Val Trp Lys His Ser Ser Gly Gly Ser Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Ile Met Val Val Leu Leu Phe Phe Gly Pro Thr Met Phe 245 250 255 Val Tyr Thr Trp Pro His Pro Lys Ser Gln Met Asp Lys Phe Leu Ala 260 265 270 Ile Phe Asp Ala Val Leu Thr Pro Phe Leu Asn Pro Val Ile Tyr Thr 275 280 285 Phe Arg Asn Lys Asp Met Lys Ser Ala Met Lys Arg Val Cys Arg Gln 290 295 300 Leu Val Ile Tyr Arg Lys Ile Ser

305 310

Page 1912

069269_0225_SL.TXT <210> 1703 <211> 840 <212> DNA <213> Canis familiaris <400> 1703

tttctcatgt tgatattctc cttaatctct ttaagagatc atccaaggaa atctcttcat 60 tttctttttg gtaattttag acttccgtta cattttccaa tgtacttcct cctggctaat 120 ctgcacctca ttgatatgga tcttttcttt atcacagtgt ctaagatgat tacagacctt 180 ttaaatgaat gcaagataat tcctttccaa agctgcatga cacagatatg cttcatccac 240 atcatgggag gagtagagat gatgctgctc ataaccatgg catttgacag gtacattgca 300 atctgtaggc ctcttcacta cctgaacatc aggaatccta caatatgtgt ttcatttgta 360 actactagct gggtcattgg gctgatctac gtgtgtctca ctttgttttc attatgaact 420 tgtacttttg aggtcctaat aaagcaaaaa gcttctgtta taactctcct agaataaaaa 480 aacttgcatg catgtctgga gccaagtttg agtttattat tgctgccagc agtaatgtca 540 tgagcatgag caccttcttt ctgctaatct ttcctatacc ttcattttag tcactgtctg 600 gaaatgttct tcaaaagact tatccaggta cttgtcactg agtcagctca cgtcactgtg 660 atggttctat ttttcagtcc atatatattt ctctatgtct ggtcttttcc caaatcatca 720 agtgataaat gcctgttcac tgctgacttt gctatcaacc atgtcttgaa tcctgccatc 780 tatacattat agaacaaaga tgtaaaggta gcaacaagaa gattgtacaa gcagggacat 840

<210> 1704 <211> 138 <212> PRT <213> Canis familiaris

<400> 1704 Phe Ser Leu Ile Ser Leu Arg Asp 10 His Pro Arg 15 Phe 1 Leu Met Leu Ile 5 Lys Ser Leu His Phe Leu Phe Gly Asn Phe Arg Leu Pro Leu His Phe 20 25 30 Pro Met Tyr Phe Leu Leu Ala Asn Leu His Leu Ile Asp Met Asp Leu 35 40 45

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Phe Phe 50 Ile Thr Val Ser Lys Met Ile Thr Asp Leu Leu Asn Glu Cys 55 60 Lys Ile Ile Pro Phe Gln Ser Cys Met Thr Gln Ile Cys Phe Ile His 65 70 75 80 Ile Met Gly Gly Val Glu Met Met Leu Leu Ile Thr Met Ala Phe Asp 85 90 95 Arg Tyr Ile Ala Ile Cys Arg Pro Leu His Tyr Leu Asn Ile Arg Asn 100 105 110 Pro Thr Ile Cys Val Ser Phe Val Thr Thr Ser Trp Val Ile Gly Leu 115 120 125 Ile Tyr Val Cys Leu Thr Leu Phe Ser Leu

130 135 <210> 1705 <211> 933 <212> DNA <213> Canis familiaris <400> 1705

atgaattact ccatggtgac tgagttcatt tttctgagac tctctaattc tcaggaattg 60 cagattttcc cttttgtgtt ctttgttgta ttctatgtag gaattgtgtg tggaaacctt 120 cctattgtca taactgtggc ctctgactcc taccttcact cccccttgta cttcctgctg 180 gctaacctct cactcattga cctatgtctg tcttcagtca cagcccccaa gatgattgct 240 gacattttta gtaaacacaa agtcatttct ttcaagggct gccttgctca gctatttatc 300 ctttactttt ttggtgggag caagctggtg atccttatag ccatggcctt tgacagatat 360 gtaacaatct gtaaaccacc tcgctacact acagttatgc tacactacag ttatgtgtgt 420 gttggccttg tggctgctgc atggggaact ggcttcctcc attcagtcag ccagctggcc 480 tttgcagtga acttaccttt ctgtggtccc aatgaggttg acagttttta ttgtgacctc 540 cctagggtta tcaaacttcc ttgtacagat atctataggt tggatatcat ggtcattgct 600 aacactggtg tgctcactgt gtgttcttta ttttccttta ttttcctaat catctcctat 660

Page 1914

069269_0225_SL.TXT gctatcatcc tagtgaccat ccagcaacac ccttcagaca agtcatccaa ggcactgtcc actttgactg ctcacgtcac agtagttctt ttgttctttg gaccatgtat cttcatttat gcctggccat tccccatgaa gtcattagat gaattccttc ctgtgtttta ttatgtggtc actcctgtct tgaacccaat tatatataca ctgaggaaca aggacatgaa gactgcactg aaatggctga gaaaatggca tgtaaactct agg

720

780

840

900

933 <210> 1706 <211> 311 <212> PRT <213> Canis familiaris

<400> 1706 Ser Met 5 Val Thr Glu Phe Ile Phe Leu Arg Leu Ser Asn Met 1 Asn Tyr 10 15 Ser Gln Glu Leu Gln Ile Phe Pro Phe Val Phe Phe Val Val Phe Tyr 20 25 30 Val Gly Ile Val Cys Gly Asn Leu Pro Ile Val Ile Thr Val Ala Ser 35 40 45 Asp Ser Tyr Leu His Ser Pro Leu Tyr Phe Leu Leu Ala Asn Leu Ser 50 55 60 Leu Ile Asp Leu Cys Leu Ser Ser Val Thr Ala Pro Lys Met Ile Ala 65 70 75 80 Asp Ile Phe Ser Lys His Lys Val Ile Ser Phe Lys Gly Cys Leu Ala 85 90 95 Gln Leu Phe Ile Leu Tyr Phe Phe Gly Gly Ser Lys Leu Val Ile Leu 100 105 110 Ile Ala Met Ala Phe Asp Arg Tyr Val Thr Ile Cys Lys Pro Pro Arg 115 120 125 Tyr Thr Thr Val Met Leu His Tyr Ser Tyr Val Cys Val Gly Leu Val 130 135 140

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Ala 145 Ala Ala Trp Gly Thr 150 Gly Phe Leu His Ser Val 155 Ser Gln Leu Ala 160 Phe Ala Val Asn Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Ser Phe 165 170 175 Tyr Cys Asp Leu Pro Arg Val Ile Lys Leu Pro Cys Thr Asp Ile Tyr 180 185 190 Arg Leu Asp Ile Met Val Ile Ala Asn Thr Gly Val Leu Thr Val Cys 195 200 205 Ser Leu Phe Ser Phe Ile Phe Leu Ile Ile Ser Tyr Ala Ile Ile Leu 210 215 220 Val Thr Ile Gln Gln His Pro Ser Asp Lys Ser Ser Lys Ala Leu Ser 225 230 235 240 Thr Leu Thr Ala His Val Thr Val Val Leu Leu Phe Phe Gly Pro Cys 245 250 255 Ile Phe Ile Tyr Ala Trp Pro Phe Pro Met Lys Ser Leu Asp Glu Phe 260 265 270 Leu Pro Val Phe Tyr Tyr Val Val Thr Pro Val Leu Asn Pro Ile Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Asp Met Lys Thr Ala Leu Lys Trp Leu Arg 290 295 300 Lys Trp His Val Asn Ser Arg

305 310 <210> 1707 <211> 939 <212> DNA <213> Canis familiaris <400> 1707

Page 1916

069269_0225_SL.TXT atggaccaag taaatggctc tttggtaact gaatttgtgt tactgggact tgcacaatcc 60 ttgggaatgc agattttcct ttttgttttt ttctctttat tctatgttgg aattatctta 120 ggaaacctct tcattatgtt aacagtgatt tttgattctc acttacactc cccaatgtat 180 atcctgctgg ccaacctatc actcattgat gtgggccttt catccaccac agttcctaga 240 atgatctctg atcttttcag tggttgtaaa atcatttcct tccacaactg catgatacaa 300 atgttcttta ttcatgttat gggaggagtt gagatggtgt tgctcatagc catggcattt 360 gacaggtaca cagcgatctg caagcctctc cactatctca ctaccatgaa taccaaaacg 420 tgcatgcttt tggtagtggc tgcttggatc attggggtga ttcatgctgt atctcagttt 480 gtttttgtca taaatttacc tttttgtggc cctaataatg tagggagctt ttattgtgat 540 tttcctaggg ttattaaact tgcatgcatg gacacataca gactagaatt tgtggtcact 600 gccaacagtg gcttcatatc tatgggcaca ttctttttct taattgtatc atacatcttt 660 attctggcca ctgttagaca gcattcttca aaagacttgt ccaaagcatt tgtcactctg 720 tcagctcaca tcactgtgtt ggttttgttt ttcactccat gcatgtttct ctatgtgtgg 780 cctttcccta ccaagtcaat ggataaattt tttgccattg tggattttgt tatcactcct 840 gtattaaatc ctgccatcta tactctaagg aacagagata tgaaggtggc aatgggaagg 900 ctgagtcgac aagttgtaag ttctagagac ataccataa 939 <210> 1708 <211> 312 <212> PRT <213> Canis familiaris

<400> 1708 Met 1 Asp Gln Val Asn Gly Ser Leu Val Thr Glu Phe Val Leu Leu Gly 5 10 15 Leu Ala Gln Ser Leu Gly Met Gln Ile Phe Leu Phe Val Phe Phe Ser 20 25 30 Leu Phe Tyr Val Gly Ile Ile Leu Gly Asn Leu Phe Ile Met Leu Thr 35 40 45 Val Ile Phe Asp Ser His Leu His Ser Pro Met Tyr Ile Leu Leu Ala Page 1917

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50 55 60

Asn 65 Leu Ser Leu Ile Asp Val Gly Leu Ser Ser Thr Thr Val Pro Arg 70 75 80 Met Ile Ser Asp Leu Phe Ser Gly Cys Lys Ile Ile Ser Phe His Asn 85 90 95 Cys Met Ile Gln Met Phe Phe Ile His Val Met Gly Gly Val Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Thr Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Thr Thr Met Asn Thr Lys Thr Cys Met Leu Leu 130 135 140 Val Val Ala Ala Trp Ile Ile Gly Val Ile His Ala Val Ser Gln Phe 145 150 155 160 Val Phe Val Ile Asn Leu Pro Phe Cys Gly Pro Asn Asn Val Gly Ser 165 170 175 Phe Tyr Cys Asp Phe Pro Arg Val Ile Lys Leu Ala Cys Met Asp Thr 180 185 190 Tyr Arg Leu Glu Phe Val Val Thr Ala Asn Ser Gly Phe Ile Ser Met 195 200 205 Gly Thr Phe Phe Phe Leu Ile Val Ser Tyr Ile Phe Ile Leu Ala Thr 210 215 220 Val Arg Gln His Ser Ser Lys Asp Leu Ser Lys Ala Phe Val Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Leu Val Leu Phe Phe Thr Pro Cys Met Phe 245 250 255 Leu Tyr Val Trp Pro Phe Pro Thr Lys Ser Met Asp Lys Phe Phe Ala

Page 1918

260

069269_0225_SL.TXT 265 270

Ile Val Asp Phe Val Ile Thr Pro Val Leu Asn Pro Ala Ile Tyr Thr 275 280 285

Leu Arg Asn Arg Asp Met Lys Val Ala Met Gly Arg Leu Ser Arg Gln 290 295 300

Val Val Ser Ser Arg Asp Ile Pro

305 310 <210> 1709 <211> 939 <212> DNA <213> Canis familiaris <400> 1709

atggatgcag caaatgactc tgtggtatct gaatttgtat tgattggact ttcaaattca 60 tgggacatgc acctttttct ctttttattc ttctctgtgt tctatgtggg aattatctta 120 ggaaacctct tcattgtgtt cacggtaatt attgactgtc atttacacac ccccatgtac 180 ttcttactgg ccaatctctc cctacttgat ctaggtttat catctactac agtccccaaa 240 atgatctctg atcttttcac tgaccacaac atcatttcct ttccaaaatg catgatacag 300 atatttttta ttcatgtcat gggtggagct gagatggtgc tgctcatagc catggcatat 360 gaccggtaca ctgcaatctg taagcctctc cactacctga ccatcatgag ctctaaaatg 420 tgtgtctcct ttgtagcggc tgcctggata gtggggatag ttcatgctgt atctcagttt 480 gtttttgtca taaacttgcc cttttgtggc cctaatgaag tagatagttt ttactgtgat 540 tttcctcggg tcatgaaact tgcttgtgta gacacttata agctagagtt tgtaatcatt 600 gctaacagtg ggtttatatc catggctacc ttcttctctt taattatatc ctatatcttc 660 attttggtca ctgtctggaa acgttcttca ggggatttat ccaaagcatt tgtcacactg 720 tcagctcaca tcactgtagt gattttgttt tttatgccat gcatgtttct ctatgtgtgg 780 cctttcccta caacatcact ggataagtat ttattcattg tggacttcgc tatcacaccc 840 ctcttgaatc ctgccatcta tacattaaga aacaaagaca tgagagtggc catgagaaga 900 ctggccaaaa ggattgtggg tcttcatggg atctcataa 939

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069269_0225_SL.TXT <210> 1710 <211> 312 <212> PRT <213> Canis familiaris

<400> 1710 Gly Met 1 Asp Ala Ala Asn 5 Asp Ser Val Val Ser 10 Glu Phe Val Leu Ile 15 Leu Ser Asn Ser Trp Asp Met His Leu Phe Leu Phe Leu Phe Phe Ser 20 25 30 Val Phe Tyr Val Gly Ile Ile Leu Gly Asn Leu Phe Ile Val Phe Thr 35 40 45 Val Ile Ile Asp Cys His Leu His Thr Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Leu Leu Asp Leu Gly Leu Ser Ser Thr Thr Val Pro Lys 65 70 75 80 Met Ile Ser Asp Leu Phe Thr Asp His Asn Ile Ile Ser Phe Pro Lys 85 90 95 Cys Met Ile Gln Ile Phe Phe Ile His Val Met Gly Gly Ala Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Thr Ile Met Ser Ser Lys Met Cys Val Ser Phe 130 135 140 Val Ala Ala Ala Trp Ile Val Gly Ile Val His Ala Val Ser Gln Phe 145 150 155 160 Val Phe Val Ile Asn Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Ser 165 170 175

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Phe Tyr Cys Asp Phe Pro Arg Val Met 185 Lys Leu Ala Cys Val Asp 190 Thr 180 Tyr Lys Leu Glu Phe Val Ile Ile Ala Asn Ser Gly Phe Ile Ser Met 195 200 205 Ala Thr Phe Phe Ser Leu Ile Ile Ser Tyr Ile Phe Ile Leu Val Thr 210 215 220 Val Trp Lys Arg Ser Ser Gly Asp Leu Ser Lys Ala Phe Val Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Ile Leu Phe Phe Met Pro Cys Met Phe 245 250 255 Leu Tyr Val Trp Pro Phe Pro Thr Thr Ser Leu Asp Lys Tyr Leu Phe 260 265 270 Ile Val Asp Phe Ala Ile Thr Pro Leu Leu Asn Pro Ala Ile Tyr Thr 275 280 285 Leu Arg Asn Lys Asp Met Arg Val Ala Met Arg Arg Leu Ala Lys Arg 290 295 300 Ile Val Gly Leu His Gly Ile Ser 305 310

<210> 1711 <211> 936 <212> DNA <213> Canis familiaris <400> 1711 atggctcata caaatgaatc agtggtgtct gagtttgtgc ttctgggact ttctaattct tgggaacttc agcttttctt ttttgccatc ttctctttag tgtatgtgac atcagtgctg ggcaacatta tgatcattgt tataatttcc tctgattccc atttgaactc tcctatgtat tttctgctcg gtaacctttc tttcattgat atctgccaat ctaattttgc cacccccaag atgcttatgg acttctttgt tgaacacaag actatctctt ttgagggctg tatggcccag

120

180

240

300

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atattccttc ttcatagttt tgttgggagt gagatgctgc tgcttgttgg tatggcatat 360 gatagattta tagccatctg taagccccta cactatagca caattatgaa tcggagccta 420 tgtataattt ttgtgtttat ttcctgggct gtgggtattc ttcattctat aagtcacttg 480 gcttttacag tggatctgcc attctgtggc cccaatgagg taaatagctt cttttgtgac 540 cttcccctgg tgatagagct ggcttgtatg gatacttatg aaatggaaat tatgacccta 600 actaacagta gcctgatatc attgggctgt tttctagctt tagttatttc ctacaccata 660 attttgatta ctgttcgtca ccggtcctct agtgggtcat ccaaggcact ttctacatta 720 actgctcaca tcacagtagt gattcttttc tttgggccct gcatttactt ctatatatgg 780 ccttttagca ggctttctgt ggataagttc ctttctgtat tctacactgt ctgtacaccc 840 ttgttgaatc ccatcatcta ctctctaagg aatgaggatg ttaaatcagc catgcgaagg 900 ctgagaaacc atcatgtgaa ctcctggaaa aactag 936

<210> 1712 <211> 311 <212> PRT <213> Canis familiaris <400> 1712

Met 1 Ala His Thr Asn 5 Glu Ser Val Val Ser Glu Phe Val Leu Leu Gly 10 15 Leu Ser Asn Ser Trp Glu Leu Gln Leu Phe Phe Phe Ala Ile Phe Ser 20 25 30 Leu Val Tyr Val Thr Ser Val Leu Gly Asn Ile Met Ile Ile Val Ile 35 40 45 Ile Ser Ser Asp Ser His Leu Asn Ser Pro Met Tyr Phe Leu Leu Gly 50 55 60 Asn Leu Ser Phe Ile Asp Ile Cys Gln Ser Asn Phe Ala Thr Pro Lys 65 70 75 80 Met Leu Met Asp Phe Phe Val Glu His Lys Thr Ile Ser Phe Glu Gly

85 90 95

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Cys Met Ala Gln 100 Ile Phe Leu Leu His Ser Phe Val Gly Ser Glu Met 105 110 Leu Leu Leu Val Gly Met Ala Tyr Asp Arg Phe Ile Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Ile Met Asn Arg Ser Leu Cys Ile Ile Phe 130 135 140 Val Phe Ile Ser Trp Ala Val Gly Ile Leu His Ser Ile Ser His Leu 145 150 155 160 Ala Phe Thr Val Asp Leu Pro Phe Cys Gly Pro Asn Glu Val Asn Ser 165 170 175 Phe Phe Cys Asp Leu Pro Leu Val Ile Glu Leu Ala Cys Met Asp Thr 180 185 190 Tyr Glu Met Glu Ile Met Thr Leu Thr Asn Ser Ser Leu Ile Ser Leu 195 200 205 Gly Cys Phe Leu Ala Leu Val Ile Ser Tyr Thr Ile Ile Leu Ile Thr 210 215 220 Val Arg His Arg Ser Ser Ser Gly Ser Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Thr Ala His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Cys Ile Tyr 245 250 255 Phe Tyr Ile Trp Pro Phe Ser Arg Leu Ser Val Asp Lys Phe Leu Ser 260 265 270 Val Phe Tyr Thr Val Cys Thr Pro Leu Leu Asn Pro Ile Ile Tyr Ser 275 280 285 Leu Arg Asn Glu Asp Val Lys Ser Ala Met Arg Arg Leu Arg Asn His 290 295 300

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His Val Asn Ser Trp Lys Asn 305 310 <210> 1713 <211> 951 <212> DNA <213> Canis familiaris <400> 1713

atggatgcgg ccaataagtc tgtttctgaa tttgttttgc tgggactctc taaatcctgg 60 gaactacagc tgtttttctt catggtgttt tcactgtttt atgtggcaac aatcattggt 120 aatagcctca tagtcatcac agttatagcc gactctcacc tacactctcc tatgtatttc 180 ctgcttacta acctttctgt tcttgatatg tcacttgctt cctttgccac ccctaagatg 240 gttacagact acctcactgg acataaaact atctcctttg atggctgtat cacccagata 300 ttttttctac acctttttac tggtactgag ataattttac ttatggccat gtcctttgat 360 aggtatattg caatatgcaa acctctccgc tatgcttcag tcataagtcc ctgggtgtgt 420 gttgccctcg tggtggcttc ctggattgtg ggagtcatgc attcaatgag ccaggtcata 480 tttgctctca cattaccatt ctgtggtccc aatgaagtag acagcttttt ctgtgacctt 540 cctgtggtgt tccagctggc ttgtgtggat acttatgttc tgggcctctt tatgatctca 600 actagtggca taattgcctt atcctgcttt attattttat tcaattcata tgttattgtc 660 ctggttacta tcaaacatca ttcttcaaaa ggatcatcta aggctcttac tacatgcaca 720 gctcatttca ttgttgtcct tatgtttttt gggccatgca ttcttatcta tatgtggcca 780 ctaaacagtt ttcttataga taagattctg tctgtgtttt ataccatctt cactcccatt 840 ctgaacccag taatatatac cttaaggaat caagaagtga agacagctat gaggaaactg 900 aaaaataggc ttctaaatcc caacaagaca actcctttgc attattttta g 951

<210> 1714 <211> 316 <212> PRT <213> Canis familiaris <400> 1714

Met Asp Ala Ala Asn Lys Ser Val Ser Glu Phe Val Leu Leu Gly Leu 1 5 10 15

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Ser Lys Ser Trp 20 Glu Leu Gln Leu Phe Phe Phe Met Val Phe Ser Leu 25 30 Phe Tyr Val Ala Thr Ile Ile Gly Asn Ser Leu Ile Val Ile Thr Val 35 40 45 Ile Ala Asp Ser His Leu His Ser Pro Met Tyr Phe Leu Leu Thr Asn 50 55 60 Leu Ser Val Leu Asp Met Ser Leu Ala Ser Phe Ala Thr Pro Lys Met 65 70 75 80 Val Thr Asp Tyr Leu Thr Gly His Lys Thr Ile Ser Phe Asp Gly Cys 85 90 95 Ile Thr Gln Ile Phe Phe Leu His Leu Phe Thr Gly Thr Glu Ile Ile 100 105 110 Leu Leu Met Ala Met Ser Phe Asp Arg Tyr Ile Ala Ile Cys Lys Pro 115 120 125 Leu Arg Tyr Ala Ser Val Ile Ser Pro Trp Val Cys Val Ala Leu Val 130 135 140 Val Ala Ser Trp Ile Val Gly Val Met His Ser Met Ser Gln Val Ile 145 150 155 160 Phe Ala Leu Thr Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Ser Phe 165 170 175 Phe Cys Asp Leu Pro Val Val Phe Gln Leu Ala Cys Val Asp Thr Tyr 180 185 190 Val Leu Gly Leu Phe Met Ile Ser Thr Ser Gly Ile Ile Ala Leu Ser 195 200 205 Cys Phe Ile Ile Leu Phe Asn Ser Tyr Val Ile Val Leu Val Thr Ile 210 215 220

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Lys 225 His His Ser Ser Lys Gly Ser Ser Lys Ala Leu Thr Thr Cys Thr 230 235 240 Ala His Phe Ile Val Val Leu Met Phe Phe Gly Pro Cys Ile Leu Ile 245 250 255 Tyr Met Trp Pro Leu Asn Ser Phe Leu Ile Asp Lys Ile Leu Ser Val 260 265 270 Phe Tyr Thr Ile Phe Thr Pro Ile Leu Asn Pro Val Ile Tyr Thr Leu 275 280 285 Arg Asn Gln Glu Val Lys Thr Ala Met Arg Lys Leu Lys Asn Arg Leu 290 295 300 Leu Asn Pro Asn Lys Thr Thr Pro Leu His Tyr Phe 305 310 315

<210> 1715 <211> 936 <212> DNA <213> Canis familiaris <400> 1715 atgggtggat taaatgattc tgtggtcaca gagattgtgt tactggccct ttcttgttct 60 tgggagaaaa agctctttct catcttggta tgttctttgc tctatttagc agtcatcttg 120 ggaaatcttt ttattttgtt tttggtaatt tttgattctc acctacattc tcccatgtac 180 tttctgctgg ccaacctgtc cctcattgat gtgtgtcttt cctctaccac agttcccaaa 240 ataatcaaag acctcttaaa tgaatacaaa gtaatttctt tccaaggttg tatggcacag 300 atatgcttca tccacatcat aggaggagtg gagatggtat tactcatagc catggcattt 360 gacagatgta cagcaatatg taaacctctt cactacttga aaatcatgaa ctctaaaata 420 tgtatttcat tcgtaatcac tggatgggta acgggagtga ttcatgctat gtctcagttt 480 ttatttgtta taaacttgcc tttttgtggg cctaataaag tagacagctt ttactgtgac 540 tttcctaaga tcataaaact tgcatgcaca gatgcagtca agtttgagtt tatcgttact 600

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gccaacagtg gcttcatgag catgggcacc ttcttcctgc taatcctttc ctactcattc 660 attttgatta cagtctggaa acgttcttca ggagaattat ccaaggcatt tgttactttg 720 tcagctcaca tcactgtggt ttttttgttt ttcaccccat gcatgtttct gtacgtctgg 780 ccttctcccc caccttcaat tgataaaaat ctgttcattg tggattttgc tatcatccct 840 gccctgaatc ctaccatcta tacactaagg aacaaagaca caaaggtagc tataaaaaga 900 ctgagcaaaa agatatctta ttccagattt tgttga 936

<210> 1716 <211> 311 <212> PRT <213> Canis familiaris <400> 1716

Met Gly Gly Leu Asn Asp Ser Val Val Thr Glu Ile Val Leu Leu Ala 1 5 10 15 Leu Ser Cys Ser Trp Glu Lys Lys Leu Phe Leu Ile Leu Val Cys Ser 20 25 30 Leu Leu Tyr Leu Ala Val Ile Leu Gly Asn Leu Phe Ile Leu Phe Leu 35 40 45 Val Ile Phe Asp Ser His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Leu Ile Asp Val Cys Leu Ser Ser Thr Thr Val Pro Lys 65 70 75 80 Ile Ile Lys Asp Leu Leu Asn Glu Tyr Lys Val Ile Ser Phe Gln Gly 85 90 95 Cys Met Ala Gln Ile Cys Phe Ile His Ile Ile Gly Gly Val Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Cys Thr Ala Ile Cys Lys 115 120 125

Pro Leu His Tyr Leu Lys Ile Met Asn Ser Lys Ile Cys Ile Ser Phe Page 1927

130 135 069269_0225_SL.TXT 140 Val Ile Thr Gly Trp Val Thr Gly Val Ile His Ala Met Ser Gln Phe 145 150 155 160 Leu Phe Val Ile Asn Leu Pro Phe Cys Gly Pro Asn Lys Val Asp Ser 165 170 175 Phe Tyr Cys Asp Phe Pro Lys Ile Ile Lys Leu Ala Cys Thr Asp Ala 180 185 190 Val Lys Phe Glu Phe Ile Val Thr Ala Asn Ser Gly Phe Met Ser Met 195 200 205 Gly Thr Phe Phe Leu Leu Ile Leu Ser Tyr Ser Phe Ile Leu Ile Thr 210 215 220 Val Trp Lys Arg Ser Ser Gly Glu Leu Ser Lys Ala Phe Val Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Phe Leu Phe Phe Thr Pro Cys Met Phe 245 250 255 Leu Tyr Val Trp Pro Ser Pro Pro Pro Ser Ile Asp Lys Asn Leu Phe 260 265 270 Ile Val Asp Phe Ala Ile Ile Pro Ala Leu Asn Pro Thr Ile Tyr Thr 275 280 285 Leu Arg Asn Lys Asp Thr Lys Val Ala Ile Lys Arg Leu Ser Lys Lys 290 295 300 Ile Ser Tyr Ser Arg Phe Cys 305 310

<210> 1717 <211> 849 <212> DNA <213> Canis familiaris

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069269_0225_SL.TXT <400> 1717

ttgatatttt ccttgatcta tttagggatc atcctgaaaa atctcttcat tttctttttg 60 ataatctttg attctcacct acattctcct atgtacttcc tacgggccaa cctgtccctc 120 attgatgtgg gactttcctc tacaacagtc ccaaagatga ttggggacct tttaaatgaa 180 tacaagataa tttccttcca aggttgcatg acacagatat gcttcatcca catcatggga 240 ggagtggaga tggtgctgct catagccatg gaatttgaca ggtacacggt gatctgtaag 300 cctcttcact atctgaacat catgaactct aaaatatgtg tttcatttgt aatcactggc 360 tgagtgattg gagtgatcca tgctatgtct cagtttgatt tcattataaa cttgcctttt 420 tgtggtccta atgaagtaga cagcttttac tgtgactttc tcaggatcat aaagcttgtg 480 tgcacagatg gagccaagtt tgagtttatt attgctgcca acagtggctt catgactatg 540 ggtgccttct tcctgctaat cctttcctat gtcttcattt tggtcattgt ctggaaatgt 600 gcttcaggag atgtgtccaa agcgtttgtc acactgtcat ctcacatctc tgtggtggtt 660 ctatttttca ctccatgcat gtttctctat gtctggcctt tccccatatc atcaattgac 720 aaatacttgt tcattgctga ctttgctatc accccggtct tgaatcctgc catctataca 780 ttaaaaaaca aagacataaa ggtagccata aaaagactga gcaaatgggg acattatctc 840

aaattttgc 849 <210> 1718 <211> 155 <212> PRT <213> Canis familiaris <400> 1718

Met 1 Ser Gln Phe Asp Phe Ile Ile Asn Leu Pro Phe Cys Gly Pro Asn 5 10 15 Glu Val Asp Ser Phe Tyr Cys Asp Phe Leu Arg Ile Ile Lys Leu Val 20 25 30 Cys Thr Asp Gly Ala Lys Phe Glu Phe Ile Ile Ala Ala Asn Ser Gly 35 40 45 Phe Met Thr Met Gly Ala Phe Phe Leu Leu Ile Leu Ser Tyr Val Phe

50 55 60

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Ile 65 Leu Val Ile Val Trp Lys Cys Ala Ser Gly Asp Val Ser Lys Ala 70 75 80 Phe Val Thr Leu Ser Ser His Ile Ser Val Val Val Leu Phe Phe Thr 85 90 95 Pro Cys Met Phe Leu Tyr Val Trp Pro Phe Pro Ile Ser Ser Ile Asp 100 105 110 Lys Tyr Leu Phe Ile Ala Asp Phe Ala Ile Thr Pro Val Leu Asn Pro 115 120 125 Ala Ile Tyr Thr Leu Lys Asn Lys Asp Ile Lys Val Ala Ile Lys Arg 130 135 140 Leu Ser Lys Trp Gly His Tyr Leu Lys Phe Cys 145 150 155

<210> 1719 <211> 942 <212> DNA <213> Canis familiaris <400> 1719

atgtcaatgg atggactaaa taattctgtg gtttctgagt ttgtgttgct gggactctct 60 acttcttggg aaactaaagt ttttctcatg ttgacatttt ccttgatcta tttagggata 120 atcctgggaa atctcttcat tttctttttg gtaatttttg attctcacct acattctccc 180 atgtacttcc tcctggccaa tctgtccttc attgacatgg gggttgcctc tacaacagtc 240 ccaaagatga ttggggacct tttaaatgaa tacaagataa tttccttcca aggttgcatg 300 acacagatgt gcttcattca catcatggga ggagtggaga tggtgctgct catagccatg 360 gcatttgaca ggtacatcgc aatttgtaag cctcttcact atctgaacat catgaaccct 420 aaaatatgtg tttcgtttgt aatcactggc tgggtgattg gagtgatcca tgctatgtct 480 cagtttgctt tcattataaa cttgcctttt tgtggtccta atgaggtaga cagcttttac 540 tgtgactttc ccaggatcat aaagcttgcg tgcactgatg gagttaaatt tgagtttatt 600

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attgctgcta acagtggctt catgagcatg ggcaccttct tcctgctaat cctttcctat 660 gtcttcattt tggtcactgt ctggaaacgt gcttcaggag atttatccaa agcatttgtc 720 acactgtcat ctcacatcac tgtggtggtt ctatttttca ctccatgcat gtttctctat 780 gtctggcctt tccccacatc atcaattgac aaatacctgt tcattgctga ctttgctatc 840 acccccattt taaatcccat aatatataca ttaaggaaca aagacataaa ggtatctgta 900 aagcgactga gcaaatgggg acattatggc agacgttgct aa 942

<210> 1720 <211> 313 <212> PRT <213> Canis familiaris <400> 1720

Met 1 Ser Met Asp Gly Leu Asn Asn Ser Val Val Ser Glu Phe Val Leu 5 10 15 Leu Gly Leu Ser Thr Ser Trp Glu Thr Lys Val Phe Leu Met Leu Thr 20 25 30 Phe Ser Leu Ile Tyr Leu Gly Ile Ile Leu Gly Asn Leu Phe Ile Phe 35 40 45 Phe Leu Val Ile Phe Asp Ser His Leu His Ser Pro Met Tyr Phe Leu 50 55 60 Leu Ala Asn Leu Ser Phe Ile Asp Met Gly Val Ala Ser Thr Thr Val 65 70 75 80 Pro Lys Met Ile Gly Asp Leu Leu Asn Glu Tyr Lys Ile Ile Ser Phe 85 90 95 Gln Gly Cys Met Thr Gln Met Cys Phe Ile His Ile Met Gly Gly Val 100 105 110 Glu Met Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile 115 120 125 Cys Lys Pro Leu His Tyr Leu Asn Ile Met Asn Pro Lys Ile Cys Val

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130 135 069269_0225_SL.TXT 140 Ser Phe Val Ile Thr Gly Trp Val Ile Gly Val Ile His Ala Met Ser 145 150 155 160 Gln Phe Ala Phe Ile Ile Asn Leu Pro Phe Cys Gly Pro Asn Glu Val 165 170 175 Asp Ser Phe Tyr Cys Asp Phe Pro Arg Ile Ile Lys Leu Ala Cys Thr 180 185 190 Asp Gly Val Lys Phe Glu Phe Ile Ile Ala Ala Asn Ser Gly Phe Met 195 200 205 Ser Met Gly Thr Phe Phe Leu Leu Ile Leu Ser Tyr Val Phe Ile Leu 210 215 220 Val Thr Val Trp Lys Arg Ala Ser Gly Asp Leu Ser Lys Ala Phe Val 225 230 235 240 Thr Leu Ser Ser His Ile Thr Val Val Val Leu Phe Phe Thr Pro Cys 245 250 255 Met Phe Leu Tyr Val Trp Pro Phe Pro Thr Ser Ser Ile Asp Lys Tyr 260 265 270 Leu Phe Ile Ala Asp Phe Ala Ile Thr Pro Ile Leu Asn Pro Ile Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Asp Ile Lys Val Ser Val Lys Arg Leu Ser 290 295 300 Lys Trp Gly His Tyr Gly Arg Arg Cys 305 310

<210> 1721 <211> 918 <212> DNA <213> Canis familiaris

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069269_0225_SL.TXT <400> 1721 atggatgatg caaatcagtc tgtggtgtcc gagttcattt ttcatggact ttgtgattca 60 agggagctcc agaccttcct cctactgacc tcctctatgc tctatctgat gactgtggtg 120 ggcaacctca tcgtagtgat cttattcatc acggaccctc atctccattt ccaaatgtac 180 ttcttagcca atctctcatt tgtggacttc tgccttacct cagtaactac ccccaaactg 240 accacagact tcctaaagcg tcataaaacc atctattttg gtagatgcac gagccagatc 300 ctctgtgtgc atttatttgc aggaattgag atggtgcttc ttgtgacagt ggcccatgat 360 tgttacatgg ccatctgcaa gccactccgt tactccagca tcatggacag acaaaagtac 420 atctggctag ttttgatatc atgcatcatt ggttttgtgc atgtcatgag ccgactggct 480 atgattttag atctgccctt ctgtggaccc agaagagtgg gtcacagttt tttctgtgac 540 attcctttgg tgagcaaact ggcctgcacg gacacacata ctctgaaaat gttgataaat 600 tctgacagtg gggtcttggc aacaacttgc ttccttctct tactggcctc ctacatctac 660 atcctagtaa cagtctgtct tcactctgag gatggaacat ccaagtctac atgcacctcc 720 cacattacag tgatgcttct cttctttgta ccctgcatgt tcatctatct gtggctactt 780 agcatcactt gggtggacaa gttgcttgct gtgttttaca cagtaatcac atctctcctg 840 aatccagcca cttatactct gagaaataaa gagattagga atgccatcaa gagactgata 900 agtaggttta caaatcca 918 <210> 1722 <211> 306 <212> PRT <213> Canis familiaris <400> 1722

Met 1 Asp Asp Ala Asn Gln Ser Val Val Ser Glu Phe Ile Phe His Gly 5 10 15 Leu Cys Asp Ser Arg Glu Leu Gln Thr Phe Leu Leu Leu Thr Ser Ser 20 25 30 Met Leu Tyr Leu Met Thr Val Val Gly Asn Leu Ile Val Val Ile Leu 35 40 45

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Phe Ile 50 Thr Asp Pro His Leu His Phe Gln Met Tyr Phe Leu Ala Asn 55 60 Leu Ser Phe Val Asp Phe Cys Leu Thr Ser Val Thr Thr Pro Lys Leu 65 70 75 80 Thr Thr Asp Phe Leu Lys Arg His Lys Thr Ile Tyr Phe Gly Arg Cys 85 90 95 Thr Ser Gln Ile Leu Cys Val His Leu Phe Ala Gly Ile Glu Met Val 100 105 110 Leu Leu Val Thr Val Ala His Asp Cys Tyr Met Ala Ile Cys Lys Pro 115 120 125 Leu Arg Tyr Ser Ser Ile Met Asp Arg Gln Lys Tyr Ile Trp Leu Val 130 135 140 Leu Ile Ser Cys Ile Ile Gly Phe Val His Val Met Ser Arg Leu Ala 145 150 155 160 Met Ile Leu Asp Leu Pro Phe Cys Gly Pro Arg Arg Val Gly His Ser 165 170 175 Phe Phe Cys Asp Ile Pro Leu Val Ser Lys Leu Ala Cys Thr Asp Thr 180 185 190 His Thr Leu Lys Met Leu Ile Asn Ser Asp Ser Gly Val Leu Ala Thr 195 200 205 Thr Cys Phe Leu Leu Leu Leu Ala Ser Tyr Ile Tyr Ile Leu Val Thr 210 215 220 Val Cys Leu His Ser Glu Asp Gly Thr Ser Lys Ser Thr Cys Thr Ser 225 230 235 240 His Ile Thr Val Met Leu Leu Phe Phe Val Pro Cys Met Phe Ile Tyr 245 250 255

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069269_0225_SL.TXT Leu Trp Leu Leu Ser Ile Thr Trp Val Asp Lys Leu Leu Ala Val Phe 260 265 270

Tyr Thr Val Ile Thr Ser Leu Leu Asn Pro Ala Thr Tyr Thr Leu Arg 275 280 285

Asn Lys Glu Ile Arg Asn Ala Ile Lys Arg Leu Ile Ser Arg Phe Thr 290 295 300

Asn Pro 305 <210> 1723 <211> 939 <212> DNA <213> Canis familiaris <400> 1723

atgtatgaag cgaattattc tgaagtgtct cagtttgtat tcttgggact ttctacctat 60 agaccagtgc agcattttct ccttgccttc tctacagtgt tttatgtaac aattgttttg 120 ggaaatctcc ttgtagtctt tacagtgacc tttgatcctt acttacattc ccctatgtac 180 ttccttttag ccaatctttc attcgttgac ttgtgtcttt ccaccttaac ggttcccaag 240 atgatatctg accttcaatc agggcacaaa actatatcct ttcaaggatg tgtcatccag 300 atatttgccc ttcatgtcct gggtggatct gagatggtgc tgctcatctc catggccttg 360 gatcgatatg tggccatatg taagcccctc cactacctga ctatcatgag cccgcagatg 420 tgcattttgc ttctgtctgg tgcttgggct gttggcctca ttcattcagt ggtccagtta 480 gcttttgtta tccatttgcc tttttgtggt cctaatgaga tagacagctt ttactgtgac 540 cttccttggt tcatcaaact tgcctgtgca gacacttaca gaatggaatt catggtgact 600 gccaacagtg ggttcatttc catgggcacc ttcttctcgt tgcttatctc ctatgtcttc 660 attctggtca ctgtctggaa acgttcctca gctggtttgt ctaaggcctt ttcaactctg 720 tcagcgcaca tcactgtggt ggttttgttc tttgtaccgt gcatctttgt ttacgtgtgg 780 ccatttccct cagtgccagt ggataagttt cttgccgttt tgaactttgt gattacaccc 840 attctgaatc ctattatcta cacattgagg aacaaagaca tgaagatggc actgaagaga 900

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939

069269_0225_SL.TXT ctgagtagtc agctcctgag tttgagaatg atctcctaa <210> 1724 <211> 312 <212> PRT <213> Canis familiaris <400> 1724

Met 1 Tyr Glu Ala Asn 5 Tyr Ser Glu Val Ser Gln Phe Val Phe Leu Gly 10 15 Leu Ser Thr Tyr Arg Pro Val Gln His Phe Leu Leu Ala Phe Ser Thr 20 25 30 Val Phe Tyr Val Thr Ile Val Leu Gly Asn Leu Leu Val Val Phe Thr 35 40 45 Val Thr Phe Asp Pro Tyr Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Leu Cys Leu Ser Thr Leu Thr Val Pro Lys 65 70 75 80 Met Ile Ser Asp Leu Gln Ser Gly His Lys Thr Ile Ser Phe Gln Gly 85 90 95 Cys Val Ile Gln Ile Phe Ala Leu His Val Leu Gly Gly Ser Glu Met 100 105 110 Val Leu Leu Ile Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Thr Ile Met Ser Pro Gln Met Cys Ile Leu Leu 130 135 140 Leu Ser Gly Ala Trp Ala Val Gly Leu Ile His Ser Val Val Gln Leu 145 150 155 160 Ala Phe Val Ile His Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp Ser 165 170 175

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Phe Tyr Cys Asp Leu Pro Trp Phe Ile Lys Leu Ala Cys Ala 190 Asp Thr 180 185 Tyr Arg Met Glu Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Met 195 200 205 Gly Thr Phe Phe Ser Leu Leu Ile Ser Tyr Val Phe Ile Leu Val Thr 210 215 220 Val Trp Lys Arg Ser Ser Ala Gly Leu Ser Lys Ala Phe Ser Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe 245 250 255 Val Tyr Val Trp Pro Phe Pro Ser Val Pro Val Asp Lys Phe Leu Ala 260 265 270 Val Leu Asn Phe Val Ile Thr Pro Ile Leu Asn Pro Ile Ile Tyr Thr 275 280 285 Leu Arg Asn Lys Asp Met Lys Met Ala Leu Lys Arg Leu Ser Ser Gln 290 295 300 Leu Leu Ser Leu Arg Met Ile Ser

305 310 <210> 1725 <211> 879 <212> DNA <213> Canis familiaris <400> 1725 ggggacttga gattttctct ttttttcata tttttgtagt cctatgcagc gattgtggca ggaaaccttc ccatcatggt cactgtgacc tctgactcac ttctgtactc cacaccaatg tacttcctct ttggaaacct ctcctttctg gatatgtcta tttccacaat cacaacccct aagatggtca tagatctcct cagggagaac agaacgattt ctttgtatgg ctcagatgtt ctaactccac ctcttagggg gcactgaatg actcttctca tagtcatggc tgttgatcgg

120

180

240

300

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069269_0225_SL.TXT tacattgcaa tatgcaaacc tcttcactac acacccatca taaactgcca ggtccttgtg 360 ggctctgtgc tgctatcctg ggctgttggc tttgtgcata cgatgagcca gatgattttt 420 actgtcacct tgaccttctg tggctccaac atagtggaca atattttttg tatatttttt 480 gtccttcctc tcattcaaaa acttgcctgc actgagacct atgttctgga gttgctagta 540 attgctgaca gtggcctgtt gtctttcacc tgctttatgc tcctgcttat ttcctacact 600 gtcattctgg taaccatccg atggcaatcc tctagtgccc tctcaaaggc tctgtccaca 660 ctgtctcttc acattactgt ggtcactctg ttctttgggc catgtatctt catttaagct 720 tggccattca gtggcttttc agtggataga tttctttctg tgttttattc agttatcaca 780 cccttagtga accccattat ttacactctg aggaaccagg agatgaaagc agtcatgaat 840 agactgagga ccaaacacat cagatccaga cagaccttc 879 <210> 1726 <211> 31 <212> PRT <213> Canis familiaris

<400> 1726 Glu Gly Leu Ser Gly Ser Asp Val Phe Gly Pro Gln Ser Ile His Asp 1 5 10 15

Cys Phe His Leu Leu Val Pro Gln Ser Val Asn Asn Gly Val His 20 25 30

<210> 1727 <211> 927 <212> DNA <213> Canis familiaris <400> 1727 atggagacag agaacagcac agtgttgaca gacttcattc tcttgggtct gacccagtct 60 caacatgttc agctcctggt cttcgtgctt gtcttaggtt tctatctcat catcctccct 120 ggaaacttcc ttatcatcct caccatcaga tcagaccctg gcctcacagc ccccctctac 180 ttctttctgg gaaacttggc tttcctggat gcatcctact ctttcattgt ggctcccagg 240 atgctggtgg acttcctctc caagaagaaa ataatctcct acagaggttg catcactcag 300

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ctctttttct tgcacttcct gggggcgggg gaaatgttcc ttcttgttgt gatggccttt 360 gaccgctaca tcgccatctg tcatcccttg cactattcca ccatcatgaa ccctagagtc 420 tgctacacct tgctgctggc cctgtggctt gggggatttg ctcattccat tgtacaagta 480 gcccttattc tccacttgcc gttctgtggc cccaaccagt tggataactt cttctgtgat 540 gtgccgcaag tcatcaagct ggcctgcaca gacacctttg tggtggagct cctgatggtc 600 tccaacagtg gcctgctcac tctgctgtgc ttcctgggac ttctggcctc ctatgcagtc 660 atcctctgcc gtgtgaaggg acactcctct gaagggaaga acaaggctct ttccacatgt 720 actacacaca ttatcattgt gtttctcatg tttggacctg ccatcttcat ctacactcga 780 cccttcagag ccttcccagc tgacaaagta gtttctctct ttcacacagt catctttcct 840 ttgatgaacc ctgtgattta tacgcttcgc aaccaagaag tgaaagcttc catgaagagg 900 ttattgagtc gtcacatggc ttgctga 927

<210> 1728 <211> 308 <212> PRT <213> Canis familiaris <400> 1728

Met Glu Thr Glu Asn Ser Thr Val Leu Thr Asp Phe Ile Leu Leu Gly 1 5 10 15 Leu Thr Gln Ser Gln His Val Gln Leu Leu Val Phe Val Leu Val Leu 20 25 30 Gly Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Leu Thr 35 40 45 Ile Arg Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg 65 70 75 80 Met Leu Val Asp Phe Leu Ser Lys Lys Lys Ile Ile Ser Tyr Arg Gly 85 90 95

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Cys Ile Thr Gln 100 Leu Phe Phe Leu His Phe Leu Gly Ala Gly Glu Met 105 110 Phe Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys His 115 120 125 Pro Leu His Tyr Ser Thr Ile Met Asn Pro Arg Val Cys Tyr Thr Leu 130 135 140 Leu Leu Ala Leu Trp Leu Gly Gly Phe Ala His Ser Ile Val Gln Val 145 150 155 160 Ala Leu Ile Leu His Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 165 170 175 Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Val Val Glu Leu Leu Met Val Ser Asn Ser Gly Leu Leu Thr Leu 195 200 205 Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg 210 215 220 Val Lys Gly His Ser Ser Glu Gly Lys Asn Lys Ala Leu Ser Thr Cys 225 230 235 240 Thr Thr His Ile Ile Ile Val Phe Leu Met Phe Gly Pro Ala Ile Phe 245 250 255 Ile Tyr Thr Arg Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser 260 265 270 Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Val Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Ala Ser Met Lys Arg Leu Leu Ser Arg 290 295 300

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His Met Ala Cys

305 <210> 1729 <211> 897 <212> DNA <213> Canis familiaris <400> 1729 atggatctta aaaatggatc tgtagtgact gagtttattt tactaggatt ttctggacga 60 tgggaacttc agattttcct ctttgtaaca ttctccttta tctacagcgc taccgtgtgg 120 ggaaatattc tcattatggt cacagtaaca tttgattcca cccttcattc tcccatgtac 180 ttcctccttg gaaacctctt tttttttgga tacgtgtctc ttcactgcca ccacacctga 240 tcatggactt gctcaatgaa cacaagacca tttccatacg gggctgcatg actcatgttc 300 tttatgcact tgtttggggg tgctgaggca actcttttga tagccatggc cttcgacaga 360 tatgtagcca tatgtaaccc cctgcactat aggacaatca tgagccacag gctgatgagt 420 gggtttataa tactatcatg gacaattggt tttgtacaca acatgagcca gatggtttta 480 acagtcaact tgcctttctg tggccccaat gtcatagaca atatattctg tgaccttgtg 540 attaggcttg ctgcttgctt gatggacaca tataccctgg aattctttgt cattgctgac 600 agagggctgc tctcattcat ctgtttcatc ttgctgcttg tctcctacac tgtcatcctg 660 atcactgtac aacaaagatc atccaggggg ctcgccaagg ctctgccaac actgtctgca 720 cacatcattg tggtcactct gttctttggg ccttgtatct ttatctatgc ctggtcattc 780 aatagttttg caagcaataa agtccttgct ttattttaca ctgttatcac acccttactg 840 aatcctatta tttatacact aagaaatcag aagatgcaag gggccatgag aaaattg 897 <210> 1730 <211> 201 <212> PRT <213> Canis familiaris <400> 1730

Met Phe Phe Met His Leu Phe Gly Gly Ala Glu Ala Thr Leu Leu Ile 1 5 10 15

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Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu His Tyr 20 25 30 Arg Thr Ile Met Ser His Arg Leu Met Ser Gly Phe Ile Ile Leu Ser 35 40 45 Trp Thr Ile Gly Phe Val His Asn Met Ser Gln Met Val Leu Thr Val 50 55 60 Asn Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Asn Ile Phe Cys Asp 65 70 75 80 Leu Val Ile Arg Leu Ala Ala Cys Leu Met Asp Thr Tyr Thr Leu Glu 85 90 95 Phe Phe Val Ile Ala Asp Arg Gly Leu Leu Ser Phe Ile Cys Phe Ile 100 105 110 Leu Leu Leu Val Ser Tyr Thr Val Ile Leu Ile Thr Val Gln Gln Arg 115 120 125 Ser Ser Arg Gly Leu Ala Lys Ala Leu Pro Thr Leu Ser Ala His Ile 130 135 140 Ile Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr Ala Trp 145 150 155 160 Ser Phe Asn Ser Phe Ala Ser Asn Lys Val Leu Ala Leu Phe Tyr Thr 165 170 175 Val Ile Thr Pro Leu Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Gln 180 185 190 Lys Met Gln Gly Ala Met Arg Lys Leu

195 200 <210> 1731 <211> 942 <212> DNA <213> Canis familiaris

Page 1942

069269_0225_SL.TXT <400> 1731

atggatgaaa accaaacaga gatggtgaga aactttgtcc tggcaggctt ctcacagacc 60 ccatctattg aggcagggtt atttgtacta tttcttttct tctacatgtc cacttgggta 120 ggcaatgtgc tcatcatggt cacagtggcc tctgataact atctgaattc atcacccatg 180 tatttccttc ttggcaacct ctctttcctg gacttatgtt attcaacagt aactacccct 240 aagcttctgg ctgatcttct gaataatgag aagctcattc gctatgacca atgcatcgtg 300 cagctcttct ttctgcattt tgtaggggca gctgagatgt tcctgctcac agtaatggcc 360 tatgatcgtt atgttgcaat atgtcgccct ctgcattata ccactattat gagtcgagga 420 ttatgctgta tgttggtagc tgcctcctgg atgggagggt ttgtgcactc tactgtccag 480 atgatcctca ctatccattt gcctttttgt ggaccaaacc atgtggacaa cttcttttgt 540 gatgttcccc ctgtcatcaa acttgcctgc gcagacacat ttgttattga attgctaatg 600 gtatctaaca gtgggttgat ctccaccagt tcctttgtgg tactgctttc ttcctattcc 660 actatcctgg tcaagattcg ctccaaggag ggaaggcgaa aggcactcgc cacctgtggc 720 tcccacctta tggtggtaac actcttcttt ggaccctgta ttttcatcta tgctcgtccc 780 ttctccacat tttctgtgga caaaatggtg tctgtactct acaatgttat tacacccatg 840 ctgaatcccc tcatctacac acttcggaac aaagaggtca agtcagccat gcggaaactg 900 tgggacagga gtgaacttac ttggaaaaag caggagacat aa 942

<210> 1732 <211> 313 <212> PRT <213> Canis familiaris <400> 1732

Met 1 Asp Glu Asn Gln Thr Glu Met Val Arg Asn Phe Val Leu Ala Gly 5 10 15 Phe Ser Gln Thr Pro Ser Ile Glu Ala Gly Leu Phe Val Leu Phe Leu 20 25 30 Phe Phe Tyr Met Ser Thr Trp Val Gly Asn Val Leu Ile Met Val Thr 35 40 45

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Val Ala 50 Ser Asp Asn Tyr Leu Asn 55 Ser Ser Pro Met Tyr Phe Leu 60 Leu Gly Asn Leu Ser Phe Leu Asp Leu Cys Tyr Ser Thr Val Thr Thr Pro 65 70 75 80 Lys Leu Leu Ala Asp Leu Leu Asn Asn Glu Lys Leu Ile Arg Tyr Asp 85 90 95 Gln Cys Ile Val Gln Leu Phe Phe Leu His Phe Val Gly Ala Ala Glu 100 105 110 Met Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Arg Pro Leu His Tyr Thr Thr Ile Met Ser Arg Gly Leu Cys Cys Met 130 135 140 Leu Val Ala Ala Ser Trp Met Gly Gly Phe Val His Ser Thr Val Gln 145 150 155 160 Met Ile Leu Thr Ile His Leu Pro Phe Cys Gly Pro Asn His Val Asp 165 170 175 Asn Phe Phe Cys Asp Val Pro Pro Val Ile Lys Leu Ala Cys Ala Asp 180 185 190 Thr Phe Val Ile Glu Leu Leu Met Val Ser Asn Ser Gly Leu Ile Ser 195 200 205 Thr Ser Ser Phe Val Val Leu Leu Ser Ser Tyr Ser Thr Ile Leu Val 210 215 220 Lys Ile Arg Ser Lys Glu Gly Arg Arg Lys Ala Leu Ala Thr Cys Gly 225 230 235 240 Ser His Leu Met Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe Ile 245 250 255

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Tyr Ala Arg Pro Phe Ser Thr Phe Ser 265 Val Asp Lys Met Val 270 Ser Val 260 Leu Tyr Asn Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu 275 280 285 Arg Asn Lys Glu Val Lys Ser Ala Met Arg Lys Leu Trp Asp Arg Ser 290 295 300 Glu Leu Thr Trp Lys Lys Gln Glu Thr 305 310

<210> 1733 <211> 972 <212> DNA <213> Canis familiaris <400> 1733

atggatggag gaaatcactc tgtggtgtct gaatttttgt tactgggact caccagttct 60 tgggagattc agattcttct ttttttgttt tttactatat tttacatagc aagtatgcta 120 ggaaaccttc tcattgtggt cactatcatc tcagaccatc acttacattc acctatgtat 180 tttttgctgg caaatctttc catcatcgac acaggtgttt ctagcattgc aagcccaaag 240 atgatttatg accttttcag aaaacataaa gtcatctcct tgacagggtg cattactcag 300 atgtttttca ttcacactgt tgggggtaca gagatggtgc tgctcattgt catggcctat 360 gaccgataca ttgctatctg taagcccctc cactacctga gcattatgag cctaagaatg 420 tgcatttctc ttctggctgt tgcttggacc attggactca tccattctgt ggcccaactg 480 gcttttgttg taaacttgcc cttttgtggt cccaacacaa tggatagttt ttattgtgat 540 tttcctcggt tcatcaaact tgcatgtaca gacacataca gactggagtt tctggtcact 600 gccaacagtg ggttcatctc tatgggtacc ttcttcatct tgattgtgtc ttatatcttc 660 atcctggtca cagtttgcaa acattcttca ggtggtccat ccaaggccct ctccactctc 720 tctgctcaca tcaccgtggt ggtctttttc tttggtcctt gcattattgt ctatgtgtgg 780 ccattcccta ccttacccat agataaattt ttagccatct ttgatgccct tatcactcct 840 ttcatgaatc ctgttatcta tactttcaga aataaggata tgaaagtggc aatgaggaga 900

Page 1945

069269_0225_SL.TXT ctgtttggta aggttttaaa tttcaggaag agttctttca tgaccagtca aagacattca gattcatctt ga

960

972 <210> 1734 <211> 323 <212> PRT <213> Canis familiaris <400> 1734

Met Asp 1 Gly Gly Asn His Ser Val Val Ser Glu Phe Leu Leu Leu Gly 5 10 15 Leu Thr Ser Ser Trp Glu Ile Gln Ile Leu Leu Phe Leu Phe Phe Thr 20 25 30 Ile Phe Tyr Ile Ala Ser Met Leu Gly Asn Leu Leu Ile Val Val Thr 35 40 45 Ile Ile Ser Asp His His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Ile Ile Asp Thr Gly Val Ser Ser Ile Ala Ser Pro Lys 65 70 75 80 Met Ile Tyr Asp Leu Phe Arg Lys His Lys Val Ile Ser Leu Thr Gly 85 90 95 Cys Ile Thr Gln Met Phe Phe Ile His Thr Val Gly Gly Thr Glu Met 100 105 110 Val Leu Leu Ile Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Ser Ile Met Ser Leu Arg Met Cys Ile Ser Leu 130 135 140 Leu Ala Val Ala Trp Thr Ile Gly Leu Ile His Ser Val Ala Gln Leu 145 150 155 160

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Ala Phe Val Val Asn Leu Pro Phe Cys Gly Pro Asn Thr Met Asp Ser 165 170 175 Phe Tyr Cys Asp Phe Pro Arg Phe Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Tyr Arg Leu Glu Phe Leu Val Thr Ala Asn Ser Gly Phe Ile Ser Met 195 200 205 Gly Thr Phe Phe Ile Leu Ile Val Ser Tyr Ile Phe Ile Leu Val Thr 210 215 220 Val Cys Lys His Ser Ser Gly Gly Pro Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Val Phe Phe Phe Gly Pro Cys Ile Ile 245 250 255 Val Tyr Val Trp Pro Phe Pro Thr Leu Pro Ile Asp Lys Phe Leu Ala 260 265 270 Ile Phe Asp Ala Leu Ile Thr Pro Phe Met Asn Pro Val Ile Tyr Thr 275 280 285 Phe Arg Asn Lys Asp Met Lys Val Ala Met Arg Arg Leu Phe Gly Lys 290 295 300 Val Leu Asn Phe Arg Lys Ser Ser Phe Met Thr Ser Gln Arg His Ser 305 310 315 320

Asp Ser Ser <210> 1735 <211> 972 <212> DNA <213> Canis familiaris <400> 1735 atggataagg tcaattcttc agtggtgtct gaatttgtat tgctgggact ctccagttct

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caggagctcc agcttttctt ttttgttttt ttctctgtgt tatatgtcat cattgtgctg 120 ggaaaccttc tcataatcat cacagtaact tctgataaca gtctgcactc ccccatgtac 180 ttcctcctag gaaatctctc ctttgtggac atctgtcagg cttcttttgc tacccctaag 240 atgattgtag atttcctgag tgaacataag accatttcct tcaatggctg catagctcag 300 atattcttca ttcacctttt tactggagga gagatggtac tacttgtctc catggcctat 360 gatagatatg tagccatatg caaacctcta cactatgtag tcatcatgag tcaaaggacg 420 tgcactgtcc tggtaatagt ctcctgggct gtgggcttgg tgcacacatt aagtcagtta 480 tcgtttaccg tgaccctacc tttttgtgga cctaatgtag tagacagctt tttttgtgat 540 cttcctcgag tgaccaaact tgcctgcctg gactcttaca tcattgaaat actcattgta 600 gtcaatagtg gtattctctc cgtaagcact ttctctctct tagttggctc tgacatcatt 660 attcttgtca ctgtctggtt taagtcttcc gctgcaatgg ccaaggcatt ttctacactg 720 gctgcccata tcactgtagt aattttgttc tttggacctt gcattttcat ctatgtgtgg 780 ccctttacca cttaccctgt ggataaactt cttgccatat tttacactgt gttcactccc 840 attctaaacc ccattatcta tacactaagg aacagggata tgaaggctgc catgaggaat 900 attatgacct attacctgag gcccaagaaa atttctgaaa ttccactagc agtgaggagt 960 tctctttatt aa 972

<210> 1736 <211> 323 <212> PRT <213> Canis familiaris

<400> 1736 Met 1 Asp Lys Val Asn Ser Ser Val Val Ser Glu Phe Val Leu Leu Gly 5 10 15 Leu Ser Ser Ser Gln Glu Leu Gln Leu Phe Phe Phe Val Phe Phe Ser 20 25 30 Val Leu Tyr Val Ile Ile Val Leu Gly Asn Leu Leu Ile Ile Ile Thr 35 40 45 Val Thr Ser Asp Asn Ser Leu His Ser Pro Met Tyr Phe Leu Leu Gly Page 1948

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50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Gln Ala Ser Phe Ala Thr Pro Lys 65 70 75 80 Met Ile Val Asp Phe Leu Ser Glu His Lys Thr Ile Ser Phe Asn Gly 85 90 95 Cys Ile Ala Gln Ile Phe Phe Ile His Leu Phe Thr Gly Gly Glu Met 100 105 110 Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Val Val Ile Met Ser Gln Arg Thr Cys Thr Val Leu 130 135 140 Val Ile Val Ser Trp Ala Val Gly Leu Val His Thr Leu Ser Gln Leu 145 150 155 160 Ser Phe Thr Val Thr Leu Pro Phe Cys Gly Pro Asn Val Val Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Arg Val Thr Lys Leu Ala Cys Leu Asp Ser 180 185 190 Tyr Ile Ile Glu Ile Leu Ile Val Val Asn Ser Gly Ile Leu Ser Val 195 200 205 Ser Thr Phe Ser Leu Leu Val Gly Ser Asp Ile Ile Ile Leu Val Thr 210 215 220 Val Trp Phe Lys Ser Ser Ala Ala Met Ala Lys Ala Phe Ser Thr Leu 225 230 235 240 Ala Ala His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Val Trp Pro Phe Thr Thr Tyr Pro Val Asp Lys Leu Leu Ala

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260

069269_0225_SL.TXT 265 270

Ile Phe Tyr Thr Val Phe Thr Pro Ile Leu Asn Pro Ile Ile Tyr Thr 275 280 285

Leu Arg Asn Arg Asp Met Lys Ala Ala Met Arg Asn Ile Met Thr Tyr 290 295 300

Tyr Leu Arg Pro Lys Lys Ile Ser Glu Ile Pro Leu Ala Val Arg Ser 305 310 315 320

Ser Leu Tyr <210> 1737 <211> 942 <212> DNA <213> Canis familiaris <400> 1737 atggggggag gaaataattc ggtagtgtct ttggagatgc agcttgtcct atttctagtt ggaaacctcc tcattgtgct cacagtgatt ctcctgctgg ccaacctctc ctttattgac atgatctctg attttttcaa ggagagaaaa atgttcttca ttcatgttat tggaggaact gaccgttatg ttgctatatg caggcctctc tgcatttcac tcctggtggt ggcctgggcc gtgtttgttg taaacctgcc attttgtggc cttcctcgat ttattaggct tgcctgcaca gccaatagtg gcttcatctc tctgggaact atcttggtca tcgtttggca acgttcctca tcagctcaca taacagtggt ggtcttattt ccatttccca cagtgccagt ggataagttc gagattgtgt ttctctgtgt tctgactcac atatgggttt gtaatctctt gagatggttc cactatctag attgggatca cccaatgagg gacacctaca ttttccattt ggtggcttgt tttggtccat cttgccattt

tggtgggact caccagttct 60 tctatgtaac aggtatttta 120 atttacattc ccccatgtac 180 cctccattgc agctcccaag 240 tccaaggctg cattgctcag 300 tgctcatttt catggccctt 360 ccatcatgaa cttcagaact 420 tccactcatt gatccaactg 480 tggacagctt ttactgtgat 540 gattagagct catggtcact 600 tggttatttc ctatatcttc 660 ccaaggccct ctctacactg 720 gtatttttgt gtactcatgg 780 ttgatgtaat tattactcca 840

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069269_0225_SL.TXT tttctgaacc ctgccatcta cacttttagg aataaagaga tgaaagtggc catgaggaga atattcagtc aggtgttgag cttccagaag ctgtttaagt ga

900

942 <210> 1738 <211> 313 <212> PRT <213> Canis familiaris <400> 1738

Met Gly 1 Gly Gly Asn Asn Ser Val Val Ser Glu Ile Val Leu Val Gly 5 10 15 Leu Thr Ser Ser Leu Glu Met Gln Leu Val Leu Phe Leu Val Phe Ser 20 25 30 Val Phe Tyr Val Thr Gly Ile Leu Gly Asn Leu Leu Ile Val Leu Thr 35 40 45 Val Ile Ser Asp Ser His Leu His Ser Pro Met Tyr Leu Leu Leu Ala 50 55 60 Asn Leu Ser Phe Ile Asp Ile Trp Val Ser Ser Ile Ala Ala Pro Lys 65 70 75 80 Met Ile Ser Asp Phe Phe Lys Glu Arg Lys Val Ile Ser Phe Gln Gly 85 90 95 Cys Ile Ala Gln Met Phe Phe Ile His Val Ile Gly Gly Thr Glu Met 100 105 110 Val Leu Leu Ile Phe Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Leu Ala Ile Met Asn Phe Arg Thr Cys Ile Ser Leu 130 135 140 Leu Val Val Ala Trp Ala Ile Gly Ile Ile His Ser Leu Ile Gln Leu 145 150 155 160

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Val Phe Val Val Asn Leu Pro Phe Cys Gly 170 Pro Asn Glu Val Asp 175 Ser 165 Phe Tyr Cys Asp Leu Pro Arg Phe Ile Arg Leu Ala Cys Thr Asp Thr 180 185 190 Tyr Arg Leu Glu Leu Met Val Thr Ala Asn Ser Gly Phe Ile Ser Leu 195 200 205 Gly Thr Phe Ser Ile Leu Val Ile Ser Tyr Ile Phe Ile Leu Val Ile 210 215 220 Val Trp Gln Arg Ser Ser Gly Gly Leu Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Val Tyr Ser Trp Pro Phe Pro Thr Val Pro Val Asp Lys Phe Leu Ala 260 265 270 Ile Phe Asp Val Ile Ile Thr Pro Phe Leu Asn Pro Ala Ile Tyr Thr 275 280 285 Phe Arg Asn Lys Glu Met Lys Val Ala Met Arg Arg Ile Phe Ser Gln 290 295 300 Val Leu Ser Phe Gln Lys Leu Phe Lys 305 310 <210> 1739 <211> 936 <212> DNA <213> Canis familiaris <400> 1739 atggctcata caaatgaatc agtggtgtct gagtttgtgc ttctgggact ttctaattct tgggaacttc agcttttctt ttttgccatc ttctctttag tgtatgtgac atcagtgctg ggcaacatta tgatcattgt tataatttcc tctgattccc atttgaactc tcctatgtat

120

180

Page 1952

069269_0225_SL.TXT

tttctgctcg gtaacctttc tttcattgat atctgccaat ctaattttgc cacccccaag 240 atgcttatgg acttctttgt tgaacacaag actatctctt ttgagggctg tatggcccag 300 atattccttc ttcatagttt tgttgggagt gagatgctgc tgcttgttgc tatggcatat 360 gatagattta tagccatctg taagccccta cactatagca caattatgaa tcggagccta 420 tgtataattt ttgtgtttat ttcttgggct gtgggtattc ttcattctat aagtcacttg 480 gcttttacag tggatctgcc attctgtggc cccaatgagg taaatagctt cttttgtgac 540 cttcccctgg tgatagagct ggcttgtatg gatacttatg aaatggaaat tatgacccta 600 actaacagta gcctgatatc attgggctgt tttctagctt tagttatttc ctacaccata 660 attttgatta ctgttcgtca ccggtcctct agtgggtcat ccaaggcact ttctacatta 720 actgctcaca tcacagtagt gattcttttc tttgggccct gcatttactt ctatatatgg 780 ccttttagca gactttctgt ggataagttc ctttctgtat tctacactgt ctgtacaccc 840 ttgttgaatc ccatcatcta ctctctaagg aatgaggatg ttaaatcagc catgcgaagg 900 ctgagaaacc atcatgtgaa ctcctggaaa aactag 936

<210> 1740 <211> 311 <212> PRT <213> Canis familiaris

<400> 1740 Met Ala His Thr 1 Asn Glu Ser Val Val Ser Glu Phe Val Leu Leu 15 Gly 5 10 Leu Ser Asn Ser Trp Glu Leu Gln Leu Phe Phe Phe Ala Ile Phe Ser 20 25 30 Leu Val Tyr Val Thr Ser Val Leu Gly Asn Ile Met Ile Ile Val Ile 35 40 45 Ile Ser Ser Asp Ser His Leu Asn Ser Pro Met Tyr Phe Leu Leu Gly 50 55 60 Asn Leu Ser Phe Ile Asp Ile Cys Gln Ser Asn Phe Ala Thr Pro Lys 65 70 75 80

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Met Leu Met Asp Phe 85 Phe Val Glu His Lys Thr Ile Ser Phe Glu Gly 90 95 Cys Met Ala Gln Ile Phe Leu Leu His Ser Phe Val Gly Ser Glu Met 100 105 110 Leu Leu Leu Val Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Ile Met Asn Arg Ser Leu Cys Ile Ile Phe 130 135 140 Val Phe Ile Ser Trp Ala Val Gly Ile Leu His Ser Ile Ser His Leu 145 150 155 160 Ala Phe Thr Val Asp Leu Pro Phe Cys Gly Pro Asn Glu Val Asn Ser 165 170 175 Phe Phe Cys Asp Leu Pro Leu Val Ile Glu Leu Ala Cys Met Asp Thr 180 185 190 Tyr Glu Met Glu Ile Met Thr Leu Thr Asn Ser Ser Leu Ile Ser Leu 195 200 205 Gly Cys Phe Leu Ala Leu Val Ile Ser Tyr Thr Ile Ile Leu Ile Thr 210 215 220 Val Arg His Arg Ser Ser Ser Gly Ser Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Thr Ala His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Cys Ile Tyr 245 250 255 Phe Tyr Ile Trp Pro Phe Ser Arg Leu Ser Val Asp Lys Phe Leu Ser 260 265 270 Val Phe Tyr Thr Val Cys Thr Pro Leu Leu Asn Pro Ile Ile Tyr Ser 275 280 285

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Leu Arg Asn Glu Asp Val Lys Ser Ala Met Arg Arg Leu Arg Asn His 290 295 300

His Val Asn Ser Trp Lys Asn

305 310 <210> 1741 <211> 975 <212> DNA <213> Canis familiaris <400> 1741

atgaatgaga caaatcattc ccgggtgacg gcgtttgtgt tgctgggact ctctaattcc 60 cgggaactcc aacctttctt gttcctccta ttttcactac tttacctagc aatactgctg 120 ggaaactttc ttatcatcct tactgtaacc tcagattccc gccttcacac ccccatgtac 180 tttctgcttg cgaacctctc ttttatagat atatgcgttg cctcttttgc tactcccaaa 240 atgattgcag actttctggt tgagcacaag actatttctt ttgatgcctg cctggctcag 300 attttctttg tccatctttt cactggcagt gaaatggtgc tccttgtatc catggcttat 360 gaccgttatg tagctatatg caaacctctc cactacatga caatcatgag ccgtcgtgtt 420 tgtattattc ttgttctcat ctcctggttt gtgggtttca tccatactac tagtcagttg 480 gcatttactg ttaacttgcc tttttgtggc cccaatgagg tagatagttt tttctgtgac 540 ctccctctag tgaccaagct ggcctgcata gacacttatg ttgtcagcct acttatagtt 600 gcagacagtg gctttctttc tatgagttcc tttctccttt tggttgtctc ctacactgtg 660 atacttatca cagttaggaa ccgctcctct gctagcatgg caaaggcccg ctccacattg 720 actgctcaca ttactgtggt cacactcttc tttggaccat gcatcttcat ctatgtgtgg 780 cccttcagta attattctgt tgacaaagtc cttgctgtat tttacaccat atttactcct 840 attttaaacc cagttatcta tactctaagg aacaaagaag tgaagacagc tatgaggaaa 900 ctgaagagtc agtatctgaa gcctggccag gtttctacag tcataagaaa tgttcttttc 960 ctggaaacaa attaa 975

<210> 1742 <211> 324

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069269_0225_SL.TXT <212> PRT <213> Canis familiaris

<400> 1742 Leu 15 Gly Met 1 Asn Glu Thr Asn His Ser Arg 5 Val Thr 10 Ala Phe Val Leu Leu Ser Asn Ser Arg Glu Leu Gln Pro Phe Leu Phe Leu Leu Phe Ser 20 25 30 Leu Leu Tyr Leu Ala Ile Leu Leu Gly Asn Phe Leu Ile Ile Leu Thr 35 40 45 Val Thr Ser Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Phe Ile Asp Ile Cys Val Ala Ser Phe Ala Thr Pro Lys 65 70 75 80 Met Ile Ala Asp Phe Leu Val Glu His Lys Thr Ile Ser Phe Asp Ala 85 90 95 Cys Leu Ala Gln Ile Phe Phe Val His Leu Phe Thr Gly Ser Glu Met 100 105 110 Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Met Thr Ile Met Ser Arg Arg Val Cys Ile Ile Leu 130 135 140 Val Leu Ile Ser Trp Phe Val Gly Phe Ile His Thr Thr Ser Gln Leu 145 150 155 160 Ala Phe Thr Val Asn Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Leu Val Thr Lys Leu Ala Cys Ile Asp Thr 180 185 190

Page 1956

Tyr Val Val 195 Ser Leu Leu Ile 069269_0225_SL.TXT Val Ala Asp Ser Gly Phe 200 205 Leu Ser Met Ser Ser Phe Leu Leu Leu Val Val Ser Tyr Thr Val Ile Leu Ile Thr 210 215 220 Val Arg Asn Arg Ser Ser Ala Ser Met Ala Lys Ala Arg Ser Thr Leu 225 230 235 240 Thr Ala His Ile Thr Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Val Trp Pro Phe Ser Asn Tyr Ser Val Asp Lys Val Leu Ala 260 265 270 Val Phe Tyr Thr Ile Phe Thr Pro Ile Leu Asn Pro Val Ile Tyr Thr 275 280 285 Leu Arg Asn Lys Glu Val Lys Thr Ala Met Arg Lys Leu Lys Ser Gln 290 295 300 Tyr Leu Lys Pro Gly Gln Val Ser Thr Val Ile Arg Asn Val Leu Phe 305 310 315 320 Leu Glu Thr Asn

<210> 1743 <211> 942 <212> DNA <213> Canis familiaris <400> 1743 atggatggag ccaacgaatc tgtggtatct gagtttgtgt tcctgggact ctccaattca tgggagatcc agcttcttct tttcctcatt ttctctgtgt tctacatggc aagcctaatg ggaaacctcc ttatcatgtt ctctgtgaga gttgacctta cattgcactc tcctatgtac ttccagctgg caaacctctc ctttcttgat gtggggattt gctctattgc agcccccaaa atggtttatg accttttcag aaaacacaaa accatctctt ttggaggttg tataccttct

120

180

240

300

Page 1957

069269_0225_SL.TXT ttattcatgc tattctttat tcatgctatt gggggtacag aaaaggtgct gctcattgcc 360 atggcctttg acagatatgt tgccatatgt aagcctctgc actacctgac catcatgagc 420 ccatgaacgt gcattttgat tttggtggca gccttggttc tcggcctcat tcactccgtg 480 gcccaactgg cttttgttgt agacttgccc ttctgtggtc ctaatgtatt ggacagcttt 540 tattgtgacc ttcctcaact cattaaactt gcttgcacgg agaccaatag attggagttc 600 atggtcacag ccaacagtgg actcatctct gtgggttcct tctttatact gattatttct 660 tacatcatca ttctgaccat agtatggaag cactcttcag gtgggttatc caagcccctc 720 tccactttgt cagctcatgt cactgtggtg gttttattct ttgggccatt aatcttcttc 780 tacacatggc cctttctctc atcacacttg gacaaatttc ttgctatctt tgatgcagtt 840 ctcacctctt ttctgaatcc ggtcatctac acattcagga acaaagagat gaaggtggca 900 atgaaaaaac tctgtcatca gcttgtgaat tacaggaaga ta 942 <210> 1744 <211> 141 <212> PRT <213> Canis familiaris <400> 1744 Met Asp Gly Ala Asn Glu Ser Val Val Ser Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Ser Asn Ser Trp Glu Ile Gln Leu Leu Leu Phe Leu Ile Phe Ser 20 25 30 Val Phe Tyr Met Ala Ser Leu Met Gly Asn Leu Leu Ile Met Phe Ser 35 40 45 Val Arg Val Asp Leu Thr Leu His Ser Pro Met Tyr Phe Gln Leu Ala 50 55 60 Asn Leu Ser Phe Leu Asp Val Gly Ile Cys Ser Ile Ala Ala Pro Lys 65 70 75 80 Met Val Tyr Asp Leu Phe Arg Lys His Lys Thr Ile Ser Phe Gly Gly 85 90 95

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Cys Ile Pro Ser Leu Phe Met Leu Phe Phe Ile His Ala Ile Gly Gly 100 105 110 Thr Glu Lys Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 Ile Cys Lys Pro Leu His Tyr Leu Thr Ile Met Ser Pro 130 135 140

<210> 1745 <211> 357 <212> DNA <213> Canis familiaris <400> 1745 atggatgaag gcaatcactc tgtggtgttg gagtttgtgt tcctgggact ctccacctcc 60 tgggagatcc agctccttct cttcctcttt tcctgtgtgt actatatggc cagcctgatg 120 ggaaacctcc tcattgtggc tgtgacctct gaccctcgtt tacaatcccc catgtactta 180 ctactggcca acctttccat cattgacttg atgttttgct cttccacagc tctcaagatg 240 atttatgatc ttttaagaga gtgcaaaacc atctcttttg ggagctttgt agctcatatc 300 ttctttatcc atgcagttag gagccctgag atggtgctgc tcatcgccat ggccttt 357 <210> 1746 <211> 119 <212> PRT <213> Canis familiaris <400> 1746

Met Asp Glu Gly Asn His Ser Val Val Leu Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Ser Thr Ser Trp Glu Ile Gln Leu Leu Leu Phe Leu Phe Ser Cys 20 25 30 Val Tyr Tyr Met Ala Ser Leu Met Gly Asn Leu Leu Ile Val Ala Val 35 40 45 Thr Ser Asp Pro Arg Leu Gln Ser Pro Met Tyr Leu Leu Leu Ala Asn 50 55 60

Page 1959

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Leu Ser Ile Ile Asp Leu Met Phe Cys Ser Ser Thr Ala Leu Lys Met 65 70 75 80 Ile Tyr Asp Leu Leu Arg Glu Cys Lys Thr Ile Ser Phe Gly Ser Phe 85 90 95 Val Ala His Ile Phe Phe Ile His Ala Val Arg Ser Pro Glu Met Val 100 105 110 Leu Leu Ile Ala Met Ala Phe

115 <210> 1747 <211> 567 <212> DNA <213> Canis familiaris <400> 1747

ctcatcgcca tggcctttga cagatatgtt gccatatgta agcctttgca ctacctgacg 60 atcatgaccc tgaggaagtg cattttattt ctagtcgctt cctggattat tggccttatt 120 cattcagtga ctcaactggc ttttgttgtg gacttgtcct tctgtgggcc taatgattta 180 gatagctttt tctgtgacct tccttggttt atcaaacttg cttgcacata cacaagcacg 240 ttgggattca tggttactgg ctttatttct gtggcctcct ttttcattct aatcatctct 300 tacaccttta ttttggtgac tattcagaaa aagtctttgg gaagtaggtc caaggccctc 360 tccactttgt cagctcatgt cactgtggtt gttttgttct ttgggccatt aatcttcttc 420 tatgtgtggc ccttccccac atcacatctg gatgaattcc ttgccgtctt tgatgcagtt 480 ctcactcctt ttctgagtct ggtcatctac gcttttagga ataaggagat gaaggtggca 540 atgaggagac tgtgttctca gttggtg 567

<210> 1748 <211> 189 <212> PRT <213> Canis familiaris <400> 1748

Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu Page 1960

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1 5 10 15 His Tyr Leu Thr Ile Met Thr Leu Arg Lys Cys Ile Leu Phe Leu Val 20 25 30 Ala Ser Trp Ile Ile Gly Leu Ile His Ser Val Thr Gln Leu Ala Phe 35 40 45 Val Val Asp Leu Ser Phe Cys Gly Pro Asn Asp Leu Asp Ser Phe Phe 50 55 60 Cys Asp Leu Pro Trp Phe Ile Lys Leu Ala Cys Thr Tyr Thr Ser Thr 65 70 75 80 Leu Gly Phe Met Val Thr Gly Phe Ile Ser Val Ala Ser Phe Phe Ile 85 90 95 Leu Ile Ile Ser Tyr Thr Phe Ile Leu Val Thr Ile Gln Lys Lys Ser 100 105 110 Leu Gly Ser Arg Ser Lys Ala Leu Ser Thr Leu Ser Ala His Val Thr 115 120 125 Val Val Val Leu Phe Phe Gly Pro Leu Ile Phe Phe Tyr Val Trp Pro 130 135 140 Phe Pro Thr Ser His Leu Asp Glu Phe Leu Ala Val Phe Asp Ala Val 145 150 155 160 Leu Thr Pro Phe Leu Ser Leu Val Ile Tyr Ala Phe Arg Asn Lys Glu 165 170 175 Met Lys Val Ala Met Arg Arg Leu Cys Ser Gln Leu Val

180 185 <210> 1749 <211> 834 <212> DNA <213> Canis familiaris

Page 1961

069269_0225_SL.TXT <400> 1749 atggatggaa tgaaccagtt gatagtatca gagtttgtgt tcctgggact cactaattca 60 tgggagatcc agcttctcct ttttgttttc tcctttttgt tctacttggc aagcatgatg 120 ggaaaccttg tcattgtgct cactgtaacc ttggatgctc atctgcattc acctatgtat 180 ttcctcctgg ctaatctctc agtcattgat atattgtttt gctcaatcac agcccctaaa 240 atgatctgtg atatttttaa aaaacacaaa gccatctctt tttgtggatg tattatgcag 300 atcttcttta gccatgcttt tgcggacact gagatggtgc tgctcattgc catggccttt 360 gacagatatg tggccatttg taagcctctg cactacttga ccatcatgag tccaaagatg 420 tgtctatacc ttttagttac ttcttgggtc attggcctca tccactcatt gttatttttt 480 ttttttttgg tccttccact cattggtgtg cctttttgtg gccctaatgt attggatagt 540 ttttattgtg accttctctg gctcctcaga cttgcctgta cagacaccca agaattagag 600 ttcatggtca ctatcaatat tgggctcatt tctgtgggct cctttatcct cttggtcatt 660 tcatatgtct taattctgtt tactgtttgg aaacattcct ctggtggctc atctaaggct 720 gtgtccactc tgtctactca catcactgtg gtggttttgt tctttgggcc gctgatgttt 780 ttctacacat ggccttctcc cacatcacac atggataaat atcttgctat tttt 834 <210> 1750 <211> 278 <212> PRT <213> Canis familiaris <400> 1750

Met Asp Gly Met Asn Gln Leu Ile Val Ser Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Thr Asn Ser Trp Glu Ile Gln Leu Leu Leu Phe Val Phe Ser Phe 20 25 30 Leu Phe Tyr Leu Ala Ser Met Met Gly Asn Leu Val Ile Val Leu Thr 35 40 45 Val Thr Leu Asp Ala His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60

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Asn 65 Leu Ser Val Ile Asp Ile Leu Phe Cys Ser Ile Thr Ala Pro Lys 70 75 80 Met Ile Cys Asp Ile Phe Lys Lys His Lys Ala Ile Ser Phe Cys Gly 85 90 95 Cys Ile Met Gln Ile Phe Phe Ser His Ala Phe Ala Asp Thr Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Thr Ile Met Ser Pro Lys Met Cys Leu Tyr Leu 130 135 140 Leu Val Thr Ser Trp Val Ile Gly Leu Ile His Ser Leu Leu Phe Phe 145 150 155 160 Phe Phe Leu Val Leu Pro Leu Ile Gly Val Pro Phe Cys Gly Pro Asn 165 170 175 Val Leu Asp Ser Phe Tyr Cys Asp Leu Leu Trp Leu Leu Arg Leu Ala 180 185 190 Cys Thr Asp Thr Gln Glu Leu Glu Phe Met Val Thr Ile Asn Ile Gly 195 200 205 Leu Ile Ser Val Gly Ser Phe Ile Leu Leu Val Ile Ser Tyr Val Leu 210 215 220 Ile Leu Phe Thr Val Trp Lys His Ser Ser Gly Gly Ser Ser Lys Ala 225 230 235 240 Val Ser Thr Leu Ser Thr His Ile Thr Val Val Val Leu Phe Phe Gly 245 250 255 Pro Leu Met Phe Phe Tyr Thr Trp Pro Ser Pro Thr Ser His Met Asp 260 265 270

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Lys Tyr Leu Ala Ile Phe 275 <210> 1751 <211> 927 <212> DNA <213> Canis familiaris <400> 1751

atgaaaaaca ggacgtttac tgagtttatt ctgttgggct tcacaaatca acctgaggtc 60 caagtcgtga tatgcatctt tttgttcctc atctatgtga taagtgtcct gggaaatttg 120 acgattatca ttctcactct agtagatcct cacctccaga cccccatgta tttcttcctc 180 cggaatttct ccttcttaga agtttccttc acatccattt ttattcccag atttctgacc 240 agtgtgacaa caggaaataa agtcatcagt tttgctggat gctttattca atattttttt 300 gctatatttc ttggggcaac agaattttac ctcttggctt ctatgtccta tgaccgctat 360 gttgccatat gcaaaccctt gcattacctg accattatga gcaatagggt ctgcatacaa 420 ctcgtgttct gctcgtggct gggaggattc ctagctatct tacccccaat catcctgatg 480 agccaggtgg atttctgtgc ctccaatatt ctgaatcact atttctgtga ctatgggcct 540 ctattggaga ttgcctgctc agacacaagc ctcctagaaa tgattatcct ttttgtggca 600 tctgtgactc tagtggttac actgctgctg gtgacatttt cttatacata cattatcagg 660 accattttga ggatcccttc tgcccagcaa aggaaaaagg ctttttccac ttgttcctcc 720 cacatgattg ttgtctccct ctcttattgc agctgcatgt ttatgtacat taatccctct 780 gcaaaagaag aaggtacttt caacaaagga atggctgtac tcattacctc aattactccc 840 ttgttaaacc ccttcattta tactctaaga aatcagcaag tgaagcaagc attcaaggac 900 accatcaaaa agattgtgaa gctttaa 927

<210> 1752 <211> 308 <212> PRT <213> Canis familiaris <400> 1752

Met Lys Asn Arg Thr Phe Thr Glu Phe Ile Leu Leu Gly Phe Thr Asn 1 5 10 15

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Gln Pro Glu Val 20 Gln Val Val Ile Cys Ile Phe Leu Phe Leu Ile Tyr 25 30 Val Ile Ser Val Leu Gly Asn Leu Thr Ile Ile Ile Leu Thr Leu Val 35 40 45 Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe Ser 50 55 60 Phe Leu Glu Val Ser Phe Thr Ser Ile Phe Ile Pro Arg Phe Leu Thr 65 70 75 80 Ser Val Thr Thr Gly Asn Lys Val Ile Ser Phe Ala Gly Cys Phe Ile 85 90 95 Gln Tyr Phe Phe Ala Ile Phe Leu Gly Ala Thr Glu Phe Tyr Leu Leu 100 105 110 Ala Ser Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His 115 120 125 Tyr Leu Thr Ile Met Ser Asn Arg Val Cys Ile Gln Leu Val Phe Cys 130 135 140 Ser Trp Leu Gly Gly Phe Leu Ala Ile Leu Pro Pro Ile Ile Leu Met 145 150 155 160 Ser Gln Val Asp Phe Cys Ala Ser Asn Ile Leu Asn His Tyr Phe Cys 165 170 175 Asp Tyr Gly Pro Leu Leu Glu Ile Ala Cys Ser Asp Thr Ser Leu Leu 180 185 190 Glu Met Ile Ile Leu Phe Val Ala Ser Val Thr Leu Val Val Thr Leu 195 200 205 Leu Leu Val Thr Phe Ser Tyr Thr Tyr Ile Ile Arg Thr Ile Leu Arg 210 215 220

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Ile Pro 225 Ser Ala Gln Gln 230 Arg Lys Lys Ala Phe Ser Thr 235 Cys Ser Ser 240 His Met Ile Val Val Ser Leu Ser Tyr Cys Ser Cys Met Phe Met Tyr 245 250 255 Ile Asn Pro Ser Ala Lys Glu Glu Gly Thr Phe Asn Lys Gly Met Ala 260 265 270 Val Leu Ile Thr Ser Ile Thr Pro Leu Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asp Thr Ile Lys Lys 290 295 300

Ile Val Lys Leu 305 <210> 1753 <211> 930 <212> DNA <213> Canis familiaris <400> 1753

atggataagg aaaatcaatc cttggcaaca gagtttatcc ttataggatt tacagatcgt 60 ccagtgctga agagtcttct gttttccgtg ttctttgcca tctatctggt gaccatggtg 120 gggaatctgg gcctggtggc attgatcctt atggagcgtc gccttcacac acccatgtac 180 atctttctgg gcaacctggc tctaatggat tcctgttgtg cctgtgccat tacccccaag 240 atgttagaga atttcttttc gaaggacaga atgatttccc tctatgaatg catggcacag 300 ttttattttc tctgccttgc tgaaactgca gactgctttc tcctggcagc aatggcctat 360 gaccgctatg tggccatctg cagcccactg cagtaccaca ccctgatgtc gaagaagctc 420 tgccttcaga tgaccgcagg ggcctacata gctagtaacc tgcattccat gatccatgta 480 gggcttctat taaggttaac tttctgcaga tctaatcaaa ttgaccactt tttttgtgac 540 attcttcccc tctatagact ctcttgtact gacccttcta tcaatgaact aatgatctat 600 attttttcaa tgccgattca aatattcacc attgccattg tcttgttctc ttatctctgc 660

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atccttttca caattttcaa aatgaagtcc aaagaaggga gaggtaaagc tttttctacc 720 tgtgcatccc actttctatc tgtttcaata ttctacattt gtcttctcat gtatattcgc 780 ccatttgaag aaggggataa agatatacca gtggcagttt tttataccat agtagttcct 840 ttattaaatc cttttatcta tagtctaaga aataaggagg tgataaatgt tcttaaaaga 900 tgtttaaaga attataatat ttttaaataa 930

<210> 1754 <211> 309 <212> PRT <213> Canis familiaris

<400> 1754 Glu Asn 5 Gln Ser Leu Ala Thr Glu Phe Ile Leu Ile Gly Met 1 Asp Lys 10 15 Phe Thr Asp Arg Pro Val Leu Lys Ser Leu Leu Phe Ser Val Phe Phe 20 25 30 Ala Ile Tyr Leu Val Thr Met Val Gly Asn Leu Gly Leu Val Ala Leu 35 40 45 Ile Leu Met Glu Arg Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ala Leu Met Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Glu Asn Phe Phe Ser Lys Asp Arg Met Ile Ser Leu Tyr Glu 85 90 95 Cys Met Ala Gln Phe Tyr Phe Leu Cys Leu Ala Glu Thr Ala Asp Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Gln Tyr His Thr Leu Met Ser Lys Lys Leu Cys Leu Gln Met 130 135 140

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Thr 145 Ala Gly Ala Tyr Ile Ala Ser Asn Leu His Ser Met Ile His Val 150 155 160 Gly Leu Leu Leu Arg Leu Thr Phe Cys Arg Ser Asn Gln Ile Asp His 165 170 175 Phe Phe Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Thr Asp Pro 180 185 190 Ser Ile Asn Glu Leu Met Ile Tyr Ile Phe Ser Met Pro Ile Gln Ile 195 200 205 Phe Thr Ile Ala Ile Val Leu Phe Ser Tyr Leu Cys Ile Leu Phe Thr 210 215 220 Ile Phe Lys Met Lys Ser Lys Glu Gly Arg Gly Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Leu Ser Val Ser Ile Phe Tyr Ile Cys Leu Leu 245 250 255 Met Tyr Ile Arg Pro Phe Glu Glu Gly Asp Lys Asp Ile Pro Val Ala 260 265 270 Val Phe Tyr Thr Ile Val Val Pro Leu Leu Asn Pro Phe Ile Tyr Ser 275 280 285 Leu Arg Asn Lys Glu Val Ile Asn Val Leu Lys Arg Cys Leu Lys Asn 290 295 300 Tyr Asn Ile Phe Lys

305 <210> 1755 <211> 936 <212> DNA <213> Canis familiaris <400> 1755

Page 1968

069269_0225_SL.TXT atggatatga ctgaggataa ttactccttg acaactgaat ttattctcat aggatttaca 60 gatcacccaa agttgaagac cgtcctgttt gtggtgtttc tcactatcta tctgatcacc 120 atggtgggga atctgggcct ggtgccattg atccttatgg agcgtcgcct tcacacaccc 180 atgtacatct ttctgggcaa cctggctcta atggattcct gttgtgcctg tgccattacc 240 cccaagatgt tagagaattt cttttcgaag gacagaatga tttccctcta tgaatgcatg 300 gcacagtttt attttttctg ccttgctgaa acggcagact gctttctcct ggcagcaatg 360 gcctatgacc gctatgtggc catctgcagc ccactgcagt accacaccct gatgtcgaag 420 aagctctgcc ttcagatgac cgcaggggcc tacatagcag gaaacctgca ttccataatt 480 catatagtgt ttctctttcg gttaactttc tgtaggtctc atcagattaa tcactttttt 540 tgtgaatttc ttccattatt caaactctcc tgtgttgacc cttatatcaa tgaattgttg 600 atgtttatct ttccaggttc agttctagtg ttctctatta tcatagtcat aatctcttat 660 ctctgcatcc ttttcatgat tttcaaaatg aaatccaaag agggaagagg cagagcctta 720 tctacttgtg catctcactt tctctctgtc tcaatgttct atggttctct tctctttgtg 780 tacattcgac caaattcagt taaagaagag gataaagata tatctgttgc tattttttat 840 actctagtaa tccctttatt aaaccctttt atttatagtc taagaaataa ggaagtgata 900 aatgctatga aaaaaaacat aaagaaaaat ttttga 936 <210> 1756 <211> 311 <212> PRT

<213> Canis familiaris <400> 1756 Met Asp Met Thr Glu Asp Asn Tyr Ser Leu Thr Thr Glu Phe Ile Leu 1 5 10 15 Ile Gly Phe Thr Asp His Pro Lys Leu Lys Thr Val Leu Phe Val Val 20 25 30 Phe Leu Thr Ile Tyr Leu Ile Thr Met Val Gly Asn Leu Gly Leu Val 35 40 45 Pro Leu Ile Leu Met Glu Arg Arg Leu His Thr Pro Met Tyr Ile Phe

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50 55 60 Leu Gly Asn Leu Ala Leu Met Asp Ser Cys Cys Ala Cys Ala Ile Thr 65 70 75 80 Pro Lys Met Leu Glu Asn Phe Phe Ser Lys Asp Arg Met Ile Ser Leu 85 90 95 Tyr Glu Cys Met Ala Gln Phe Tyr Phe Phe Cys Leu Ala Glu Thr Ala 100 105 110 Asp Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys Ser Pro Leu Gln Tyr His Thr Leu Met Ser Lys Lys Leu Cys Leu 130 135 140 Gln Met Thr Ala Gly Ala Tyr Ile Ala Gly Asn Leu His Ser Ile Ile 145 150 155 160 His Ile Val Phe Leu Phe Arg Leu Thr Phe Cys Arg Ser His Gln Ile 165 170 175 Asn His Phe Phe Cys Glu Phe Leu Pro Leu Phe Lys Leu Ser Cys Val 180 185 190 Asp Pro Tyr Ile Asn Glu Leu Leu Met Phe Ile Phe Pro Gly Ser Val 195 200 205 Leu Val Phe Ser Ile Ile Ile Val Ile Ile Ser Tyr Leu Cys Ile Leu 210 215 220 Phe Met Ile Phe Lys Met Lys Ser Lys Glu Gly Arg Gly Arg Ala Leu 225 230 235 240 Ser Thr Cys Ala Ser His Phe Leu Ser Val Ser Met Phe Tyr Gly Ser 245 250 255 Leu Leu Phe Val Tyr Ile Arg Pro Asn Ser Val Lys Glu Glu Asp Lys

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069269_0225_SL.TXT 265 270

Asp Ile Ser Val Ala Ile Phe Tyr Thr Leu Val Ile Pro Leu Leu Asn 275 280 285 Pro Phe Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Asn Ala Met Lys 290 295 300 Lys Asn Ile Lys Lys Asn Phe

305 310 <210> 1757 <211> 915 <212> DNA <213> Canis familiaris <400> 1757

atgactgagg ataattactc cttgacaact gaatttattc tcataggatt tacagatcac 60 ccaaagttga agaccattct gtttgtggtg tttctcacta tctatctggt gaccatggtg 120 gggaatctgg gcctggtgcc tttgattcta atggagcgtc gccttcacac acccatgtac 180 atctttctgg gcaacctggc tctaatggat tcctgttgtg cctgtgccat tacccccaag 240 atgttagaga atttcttttc gaaggacaga atgatttccc tctatgaatg catggcacag 300 ttttattttc tctgccttgc tgaaacggca gactgctttc tcctggcagc aatggcctat 360 gaccgctatg tggccatctg cagcccactg cagtaccaca ccctgatgtc aaagaaactc 420 tgccttcaga tgaccacagg ggcctacata gcaggaaatc tccatcccgt aattcatata 480 gtgtttctct ttcggttaac tttctgtagg tctcatcata ttaatcactt tttttgtgat 540 gttcttccat tattcaaact ctcctgtgtt gacccttata tcaatgaatt gttgatattt 600 atctttccag gctcagttct agtgttctct attatcatag tcataatctc ttatctctgc 660 attcttttca tgattttcaa aatgaaatcc aaagagggaa gaggcaaagc cttatctact 720 tgtgcatccc actttctctc tgtctcaatg ttctatggtt ctcttctttt tgtgtacgtt 780 cgaccaaatt cagttaaaga ggaggataaa gatatatctg ttgctatttt ttatactcta 840 gtaatccctt tattaaaccc ttttatttat agtctaagaa ataaagaagt aataaatgct 900 atgaaaaaaa aataa 915

Page 1971

069269_0225_SL.TXT <210> 1758 <211> 304 <212> PRT <213> Canis familiaris

<400> 1758 Met 1 Thr Glu Asp Asn 5 Tyr Ser Leu Thr Thr Glu Phe Ile Leu Ile Gly 10 15 Phe Thr Asp His Pro Lys Leu Lys Thr Ile Leu Phe Val Val Phe Leu 20 25 30 Thr Ile Tyr Leu Val Thr Met Val Gly Asn Leu Gly Leu Val Pro Leu 35 40 45 Ile Leu Met Glu Arg Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ala Leu Met Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Glu Asn Phe Phe Ser Lys Asp Arg Met Ile Ser Leu Tyr Glu 85 90 95 Cys Met Ala Gln Phe Tyr Phe Leu Cys Leu Ala Glu Thr Ala Asp Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Gln Tyr His Thr Leu Met Ser Lys Lys Leu Cys Leu Gln Met 130 135 140 Thr Thr Gly Ala Tyr Ile Ala Gly Asn Leu His Pro Val Ile His Ile 145 150 155 160 Val Phe Leu Phe Arg Leu Thr Phe Cys Arg Ser His His Ile Asn His 165 170 175

Page 1972

069269_0225_SL.TXT

Phe Phe Cys Asp Val Leu Pro Leu 180 Phe Lys 185 Leu Ser Cys Val 190 Asp Pro Tyr Ile Asn Glu Leu Leu Ile Phe Ile Phe Pro Gly Ser Val Leu Val 195 200 205 Phe Ser Ile Ile Ile Val Ile Ile Ser Tyr Leu Cys Ile Leu Phe Met 210 215 220 Ile Phe Lys Met Lys Ser Lys Glu Gly Arg Gly Lys Ala Leu Ser Thr 225 230 235 240 Cys Ala Ser His Phe Leu Ser Val Ser Met Phe Tyr Gly Ser Leu Leu 245 250 255 Phe Val Tyr Val Arg Pro Asn Ser Val Lys Glu Glu Asp Lys Asp Ile 260 265 270 Ser Val Ala Ile Phe Tyr Thr Leu Val Ile Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Asn Ala Met Lys Lys Lys 290 295 300

<210> 1759 <211> 930 <212> DNA <213> Canis familiaris <400> 1759

atgactgagg ataattactc cttgacaact gaatttattc tcataggatt tacagatcac 60 ccaaagttga agaccgttct gtttgtggtg tttctcacta tctatctggt gaccatggtg 120 gggaatctgg gcctggtggc attgatcctt atggagcgtc gccttcacac acccatgtac 180 atctttctgg gcaacctggc tctaatggat tcctgttgtg cctgtgccat tacccccaag 240 atgttagaga atttcttttc gaaggacaga atgatttccc tctatgaatg catggcacag 300 ttttattttc tctgccttgc tgaaactgca gactgctttc tcctggcagc aatggcctat 360 gaccgctatg tggccatctg cagcccactg cagtaccaca ccctgatgtc gaagaagctc 420

Page 1973

069269_0225_SL.TXT

tgccttcaga tgaccgcagg ggcctacata gcaggaaacc tgcattccat gattcatata 480 gtgtttctct ttcgtttaac tttctgtagg tctcatcaga ttaatcactt tttttgtgat 540 gttcttccat tattcaaact ctcctgtgtt gacccttata tcaatgaatt gttgatattt 600 atcttttctg cttcaatttt agtcttctct attatcatag tcataatctc ttatctctgc 660 atccttttca tgattttcag aatgaaatcc aaagagggaa gaggcagagc cttatctacc 720 tgtgcatctc actttctctc tgtctcaatg ttctatggtt ctcttctctt tgtgtacatt 780 cgaccaaatt cagttaaaga agaggataaa gataaacctg ttgctatttt ttatactcta 840 gtaatccctt tattaaatcc ttttatttat agtctaagaa ataaggaagt aataaatgcc 900 atgaaaagaa atataaagaa aattttataa 930

<210> 1760 <211> 309 <212> PRT <213> Canis familiaris <400> 1760

Met Thr Glu Asp Asn Tyr Ser Leu Thr Thr Glu Phe Ile Leu Ile Gly 1 5 10 15 Phe Thr Asp His Pro Lys Leu Lys Thr Val Leu Phe Val Val Phe Leu 20 25 30 Thr Ile Tyr Leu Val Thr Met Val Gly Asn Leu Gly Leu Val Ala Leu 35 40 45 Ile Leu Met Glu Arg Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ala Leu Met Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Glu Asn Phe Phe Ser Lys Asp Arg Met Ile Ser Leu Tyr Glu 85 90 95 Cys Met Ala Gln Phe Tyr Phe Leu Cys Leu Ala Glu Thr Ala Asp Cys 100 105 110

Page 1974

069269_0225_SL.TXT

Phe Leu Leu 115 Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 120 125 Pro Leu Gln Tyr His Thr Leu Met Ser Lys Lys Leu Cys Leu Gln Met 130 135 140 Thr Ala Gly Ala Tyr Ile Ala Gly Asn Leu His Ser Met Ile His Ile 145 150 155 160 Val Phe Leu Phe Arg Leu Thr Phe Cys Arg Ser His Gln Ile Asn His 165 170 175 Phe Phe Cys Asp Val Leu Pro Leu Phe Lys Leu Ser Cys Val Asp Pro 180 185 190 Tyr Ile Asn Glu Leu Leu Ile Phe Ile Phe Ser Ala Ser Ile Leu Val 195 200 205 Phe Ser Ile Ile Ile Val Ile Ile Ser Tyr Leu Cys Ile Leu Phe Met 210 215 220 Ile Phe Arg Met Lys Ser Lys Glu Gly Arg Gly Arg Ala Leu Ser Thr 225 230 235 240 Cys Ala Ser His Phe Leu Ser Val Ser Met Phe Tyr Gly Ser Leu Leu 245 250 255 Phe Val Tyr Ile Arg Pro Asn Ser Val Lys Glu Glu Asp Lys Asp Lys 260 265 270 Pro Val Ala Ile Phe Tyr Thr Leu Val Ile Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Asn Ala Met Lys Arg Asn 290 295 300 Ile Lys Lys Ile Leu

305

Page 1975

069269_0225_SL.TXT <210> 1761 <211> 969 <212> DNA <213> Canis familiaris <400> 1761

atggctgaag aaaatcatac cctgaaaagt gagtttatcc tcacaggatt tacagatcac 60 ccagagttga agacccttct gtttgtggtg ttctttgcca tctatctcat caccatggtg 120 gggaatctgg gcctggtggt actgatatca aaagagcatc atcttcacat gccaatgtac 180 atctttctgg gcaacctggc tcttgtggat tcttgctgtg cctcggccat tactcctaag 240 atgttagaga acttcttttc tgagaacagg atgatttccc tctatgaatg catggcacaa 300 ttttattttc tttgccttgc tgaaactgca gactgctttc tcctggcagc aatggcctat 360 gaccgctatg tggccatctg cagcccactg cagtaccaca ccatgatgtc gaagaagctc 420 tgccttcaga tgaccacagg ggcctacata gcaggaaacc tgcattccat gattcacgta 480 gggcttctcc ttaggctaac tttctgtggg tctcatcaaa ttaatcactt ttactgtgat 540 attcttcctt tatacagact ctcctgtatt gatccttatg tcaatgaact agtactattt 600 attttttcag gctccatcca agtcttcacc ataggcagcg tattaatatc ttacttctac 660 attctcttta ctattttcaa aatgaaatcc aaagaaggaa gggtcaaagc attttccacc 720 tgtgcatctc actttttgtc tgtttcattg ttctatggat ctcttttttt catgtacatt 780 agaccaaatt tgcttgaaca aggggataaa gatatcccag ctgctatttt gtttacaata 840 gtagttccct tactaaatcc ttttatttat agcctgagaa ataaagaagt aataactgtc 900 ctgagaaaaa ttttgaagaa aaaaaaatct catgaaagtt ggaaacaaat gatatcgact 960

gtagcttag 969 <210> 1762 <211> 322 <212> PRT <213> Canis familiaris <400> 1762

Met Ala Glu Glu Asn His Thr Leu Lys Ser Glu Phe Ile Leu Thr Gly 1 5 10 15

Page 1976

069269_0225_SL.TXT

Phe Thr Asp His 20 Pro Glu Leu Lys Thr Leu Leu Phe Val Val Phe Phe 25 30 Ala Ile Tyr Leu Ile Thr Met Val Gly Asn Leu Gly Leu Val Val Leu 35 40 45 Ile Ser Lys Glu His His Leu His Met Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ala Leu Val Asp Ser Cys Cys Ala Ser Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Glu Asn Phe Phe Ser Glu Asn Arg Met Ile Ser Leu Tyr Glu 85 90 95 Cys Met Ala Gln Phe Tyr Phe Leu Cys Leu Ala Glu Thr Ala Asp Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Gln Tyr His Thr Met Met Ser Lys Lys Leu Cys Leu Gln Met 130 135 140 Thr Thr Gly Ala Tyr Ile Ala Gly Asn Leu His Ser Met Ile His Val 145 150 155 160 Gly Leu Leu Leu Arg Leu Thr Phe Cys Gly Ser His Gln Ile Asn His 165 170 175 Phe Tyr Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Ile Asp Pro 180 185 190 Tyr Val Asn Glu Leu Val Leu Phe Ile Phe Ser Gly Ser Ile Gln Val 195 200 205 Phe Thr Ile Gly Ser Val Leu Ile Ser Tyr Phe Tyr Ile Leu Phe Thr 210 215 220

Page 1977

069269_0225_SL.TXT

Ile 225 Phe Lys Met Lys Ser Lys 230 Glu Gly Arg Val Lys Ala Phe Ser Thr 235 240 Cys Ala Ser His Phe Leu Ser Val Ser Leu Phe Tyr Gly Ser Leu Phe 245 250 255 Phe Met Tyr Ile Arg Pro Asn Leu Leu Glu Gln Gly Asp Lys Asp Ile 260 265 270 Pro Ala Ala Ile Leu Phe Thr Ile Val Val Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Thr Val Leu Arg Lys Ile 290 295 300 Leu Lys Lys Lys Lys Ser His Glu Ser Trp Lys Gln Met Ile Ser Thr 305 310 315 320

Val Ala

<210> 1763 <211> 915 <212> DNA <213> Canis familiaris <400> 1763 atgaaggcaa acaagacgca ggtgactgag tttgttctca caggacttac agatcgtcca 60 ggactgcagg tccccctgtt cctggtgttc ttggtcatct acctcaccac catggtgggc 120 aacctggcac tgatttttct catctggaag gacccccatc ttcacacacc catgtactta 180 ttccttggca gtttggccct cgcagatgct tcctcatctt ctgtgactcc caagatgcta 240 atgaactttt tatctaagaa tcatatgata tcccactttg agtgcatcac ccaattttat 300 atttttgctt ccagtgccac cacagagtgt ttcctcctgg tagtgatggc ctacgaccgt 360 tacgtagcca tatgcaaccc tttgcattat ccagtggtga tgtccaacag gctctgtgct 420 tggttgataa gtttgtctta tgtaattggt tttctgcatc ccacaattca tgtaggatta 480 ttatttagat taactttctg caggtccaat ataatacatc acttctactg tgaaatcttg 540

Page 1978

069269_0225_SL.TXT

ccactatata caatttcttg cactgaccca tctattaatg cattggtgct ttttattttt 600 gctgctttta tacaggcttt tacttttatg accatcatag tgtcatatac ctgggtcctc 660 tttgccatcc tgaaaaagaa gtctgaaaag ggcaggagca aagccttctc catgtgcagt 720 gcccacctgc tctctgtctc cttgttctat ggcaccctct tcttcatgta tgtgcgtcct 780 gggtctggcc cagatcaata tcaggataaa atgtattcac tgttctatac gatcatcatc 840 cccctgctaa acccctttat ttatagccca agaaacaggg aatttttagg tgcactgaga 900 aaaattacaa agaaa 915

<210> 1764 <211> 305 <212> PRT <213> Canis familiaris <400> 1764

Met 1 Lys Ala Asn Lys 5 Thr Gln Val Thr Glu Phe Val Leu Thr Gly Leu 10 15 Thr Asp Arg Pro Gly Leu Gln Val Pro Leu Phe Leu Val Phe Leu Val 20 25 30 Ile Tyr Leu Thr Thr Met Val Gly Asn Leu Ala Leu Ile Phe Leu Ile 35 40 45 Trp Lys Asp Pro His Leu His Thr Pro Met Tyr Leu Phe Leu Gly Ser 50 55 60 Leu Ala Leu Ala Asp Ala Ser Ser Ser Ser Val Thr Pro Lys Met Leu 65 70 75 80 Met Asn Phe Leu Ser Lys Asn His Met Ile Ser His Phe Glu Cys Ile 85 90 95 Thr Gln Phe Tyr Ile Phe Ala Ser Ser Ala Thr Thr Glu Cys Phe Leu 100 105 110 Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 115 120 125

Page 1979

069269_0225_SL.TXT

His Tyr Pro 130 Val Val Met Ser Asn Arg Leu Cys Ala Trp Leu Ile Ser 135 140 Leu Ser Tyr Val Ile Gly Phe Leu His Pro Thr Ile His Val Gly Leu 145 150 155 160 Leu Phe Arg Leu Thr Phe Cys Arg Ser Asn Ile Ile His His Phe Tyr 165 170 175 Cys Glu Ile Leu Pro Leu Tyr Thr Ile Ser Cys Thr Asp Pro Ser Ile 180 185 190 Asn Ala Leu Val Leu Phe Ile Phe Ala Ala Phe Ile Gln Ala Phe Thr 195 200 205 Phe Met Thr Ile Ile Val Ser Tyr Thr Trp Val Leu Phe Ala Ile Leu 210 215 220 Lys Lys Lys Ser Glu Lys Gly Arg Ser Lys Ala Phe Ser Met Cys Ser 225 230 235 240 Ala His Leu Leu Ser Val Ser Leu Phe Tyr Gly Thr Leu Phe Phe Met 245 250 255 Tyr Val Arg Pro Gly Ser Gly Pro Asp Gln Tyr Gln Asp Lys Met Tyr 260 265 270 Ser Leu Phe Tyr Thr Ile Ile Ile Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Pro Arg Asn Arg Glu Phe Leu Gly Ala Leu Arg Lys Ile Thr Lys 290 295 300

Lys

305 <210> 1765 <211> 921 <212> DNA

Page 1980

069269_0225_SL.TXT <213> Canis familiaris <400> 1765

atggaggcaa acaagacgca ggtgactgag tttgttctca taggacttac agatcgtcca 60 ggactgcagg tccccctgtt cctggtgttc ttggtcatct acctcaccac catggtgggc 120 aacctggcac tgatttttct catctggaag gacccccatc ttcacacacc catgtactta 180 ttccttggca gtttggccct cgcagatgct tgttcctcat cttctgtgac tcccaagatg 240 ctaatgaaat ttttatctaa gaatcatatg atatcccact ttgagtgcat cacccaattt 300 tatatttttg cttccagtgc caccacagag tgtttcctcc tggtagtgat ggcctacgac 360 cgttacgtag ccatatgcaa ccctttgcat tatccagtgg tgatgtccaa caggctctgt 420 gcttggttga taagtttgtc ttatgtaatt ggttttctgc atcccacaat tcatgtagga 480 ttattattta gattaacttt ctgcaggtcc aatataatac atcacttcta ctgtgaaatc 540 ttgccactat atacaatttc ttgcactgac ccatctatta atgcattggt gctttttatt 600 tttgctgctt ttatacaggc ttttactttt atgaccatca tagtgtcata tacccgggtc 660 ctctttgcca tcctgaaaaa gaagtctgaa aagggcagga gcaaagcctt ctccacgtgc 720 agcgcccacc tgctctctgt ctccttgttc tatggcaccc tcttcttcat gtatgtgcgt 780 cctgggtctg gcccagatca atatcaggat aaaatgtatt cactgttcta tatgatcatc 840 atccccctgc taaacccctt tatttatagc ctaagaaaca aggaagtttt aggtgcactg 900 agaaaaatta caaagaaata a 921

<210> 1766 <211> 306 <212> PRT <213> Canis familiaris <400> 1766

Met 1 Glu Ala Asn Lys Thr Gln Val Thr Glu Phe Val Leu Ile Gly Leu 5 10 15 Thr Asp Arg Pro Gly Leu Gln Val Pro Leu Phe Leu Val Phe Leu Val 20 25 30 Ile Tyr Leu Thr Thr Met Val Gly Asn Leu Ala Leu Ile Phe Leu Ile 35 40 45

Page 1981

069269_0225_SL.TXT

Trp Lys 50 Asp Pro His Leu His Thr Pro Met Tyr Leu Phe Leu Gly Ser 55 60 Leu Ala Leu Ala Asp Ala Cys Ser Ser Ser Ser Val Thr Pro Lys Met 65 70 75 80 Leu Met Lys Phe Leu Ser Lys Asn His Met Ile Ser His Phe Glu Cys 85 90 95 Ile Thr Gln Phe Tyr Ile Phe Ala Ser Ser Ala Thr Thr Glu Cys Phe 100 105 110 Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125 Leu His Tyr Pro Val Val Met Ser Asn Arg Leu Cys Ala Trp Leu Ile 130 135 140 Ser Leu Ser Tyr Val Ile Gly Phe Leu His Pro Thr Ile His Val Gly 145 150 155 160 Leu Leu Phe Arg Leu Thr Phe Cys Arg Ser Asn Ile Ile His His Phe 165 170 175 Tyr Cys Glu Ile Leu Pro Leu Tyr Thr Ile Ser Cys Thr Asp Pro Ser 180 185 190 Ile Asn Ala Leu Val Leu Phe Ile Phe Ala Ala Phe Ile Gln Ala Phe 195 200 205 Thr Phe Met Thr Ile Ile Val Ser Tyr Thr Arg Val Leu Phe Ala Ile 210 215 220 Leu Lys Lys Lys Ser Glu Lys Gly Arg Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ala His Leu Leu Ser Val Ser Leu Phe Tyr Gly Thr Leu Phe Phe 245 250 255

Page 1982

069269_0225_SL.TXT

Met Tyr Val Arg Pro Gly Ser Gly Pro Asp Gln Tyr Gln Asp Lys Met 260 265 270 Tyr Ser Leu Phe Tyr Met Ile Ile Ile Pro Leu Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Leu Gly Ala Leu Arg Lys Ile Thr 290 295 300

Lys Lys

305 <210> 1767 <211> 924 <212> DNA <213> Canis familiaris <400> 1767

atggcagaag aaaacaagac acagatgatt gagttcgttc tcacaggact tacaggtcat 60 ccagggccgc agatccccct cttcctggtg ttcttggtca tctacctcat cactatggtg 120 ggcaaccttg gtctggttgc tctcatcagg aaagaccccc acctgcacac ccccatgtac 180 ttattccttg gcagtttggc ctttgcagat gcttgtactt catcctctgt gactcccagg 240 atgcttataa attttttatc gaagaatcat gtgatatcac tttttgactg tatggctcaa 300 ttttacattt ttggttccag tgccaccaca gagtgtttcc tcctggtagt gatggcctat 360 gaccgctatg tagccatatg caaccctttg ctttatccag tcatgatgtc caataacctt 420 tgtactcagt tgatcggagt ctcatatttt gttggttttc tacactcagc aattcacgtg 480 ggtttgttat ttaggttaac tttctgcagg tccaatgaaa tacattcttt ctactgtgaa 540 attttacaac tcttcaaaat ttcttgtacc gatcctacag ttaacacact tctggtttta 600 attttttcgg ccttcataca aatctttacg tttatgacca tcatggtttc ttatacctgt 660 gtcctctttg ccatcctgaa aaagaagtct gaaaagggca ggagtaaagc cttctccacg 720 tgcagcgccc acttgctctc tgtctccttg ttctatggca ccctcttctt catgtatgtg 780 cgtcctgggt ctggccacac tgaagatgat gacaaaatgt attctttatt ttacacaata 840

Page 1983

900

924

069269_0225_SL.TXT ataattcctc tgctaaatcc ttttatttac agcctgagga acaaagaggt tatagatgct ttgagaagaa taattaagaa ataa <210> 1768 <211> 307 <212> PRT <213> Canis familiaris

<400> 1768 Met Ala 1 Glu Glu Asn Lys Thr Gln Met Ile Glu Phe Val Leu Thr 15 Gly 5 10 Leu Thr Gly His Pro Gly Pro Gln Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 Val Ile Tyr Leu Ile Thr Met Val Gly Asn Leu Gly Leu Val Ala Leu 35 40 45 Ile Arg Lys Asp Pro His Leu His Thr Pro Met Tyr Leu Phe Leu Gly 50 55 60 Ser Leu Ala Phe Ala Asp Ala Cys Thr Ser Ser Ser Val Thr Pro Arg 65 70 75 80 Met Leu Ile Asn Phe Leu Ser Lys Asn His Val Ile Ser Leu Phe Asp 85 90 95 Cys Met Ala Gln Phe Tyr Ile Phe Gly Ser Ser Ala Thr Thr Glu Cys 100 105 110 Phe Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Pro Val Met Met Ser Asn Asn Leu Cys Thr Gln Leu 130 135 140 Ile Gly Val Ser Tyr Phe Val Gly Phe Leu His Ser Ala Ile His Val 145 150 155 160 Gly Leu Leu Phe Arg Leu Thr Phe Cys Arg Ser Asn Glu Ile His Ser

Page 1984

069269_0225_SL.TXT

165 170 175

Phe Tyr Cys Glu Ile Leu Gln Leu Phe Lys Ile Ser Cys Thr Asp Pro 180 185 190 Thr Val Asn Thr Leu Leu Val Leu Ile Phe Ser Ala Phe Ile Gln Ile 195 200 205 Phe Thr Phe Met Thr Ile Met Val Ser Tyr Thr Cys Val Leu Phe Ala 210 215 220 Ile Leu Lys Lys Lys Ser Glu Lys Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Leu Ser Val Ser Leu Phe Tyr Gly Thr Leu Phe 245 250 255 Phe Met Tyr Val Arg Pro Gly Ser Gly His Thr Glu Asp Asp Asp Lys 260 265 270 Met Tyr Ser Leu Phe Tyr Thr Ile Ile Ile Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Asp Ala Leu Arg Arg Ile 290 295 300 Ile Lys Lys

305 <210> 1769 <211> 981 <212> DNA <213> Canis familiaris <400> 1769 atgactgtgt tcttcactta ttctttcatt tcagtgatca gcttcagtga atctgatgga aacagaacac aggtgactga gtttgttctc acagggctta cagatcatcc aggactgcag gtccccctgt tcctggtgtt cttgatcatc tacctcacca ccatggtggg caacctggca ctgatttttc tcatctggaa ggacccccat cttcacaccc ccatgtactt actccttggc Page 1985

120

180

240

069269_0225_SL.TXT

agtttggcct ttgcagatgc ttgttcctca tcttctgtga ctcccaggat gctaatggat 300 tttttatcta ggaatcatat gatatcactg gttgagtgca tcacccaatt ttatattttt 360 gcttccagtg caaacacaga gtgtttcctc ctggtagtga tggcctatga ccgctatgta 420 gccatatgca accctttgct ttatccagtg gttatgtcca atatcttctg cattcagtta 480 ttaagtgttt catatattat tgggtttctg caccctatga tgcatgtcag tttgttatgt 540 agattaactt tctgcaagtc taatgtaata cattatttct actgtgaaat tttacaattg 600 tttaagattt cctgtactga ccctagagtt aatatgctcc tgatttttat attttcagtc 660 tttatacagt ttttcacttt catgactatt atcatctctt attcctatgt cctctttgcc 720 atcctgaaaa agaagtctga aaagggcagg agcaaagcct tctccacatg tagcgcccac 780 ctgctctctg tctccttgtt ctatggcacc ctattcttca tgtatgtgcg tcctgggtct 840 gggccagctg aaaatcaaga taaaatgtat tctgtatttt acacaataat aattccccta 900 ctaaatcctt ttatttacag tctgagaaac aaagaggtga taggtgcctt gaggagaata 960 atatacataa atagttctta ^g 981

<210> 1770 <211> 326 <212> PRT <213> Canis familiaris

<400> 1770 Met Thr Val Phe 1 Phe 5 Thr Tyr Ser Phe Ile Ser Val Ile Ser Phe Ser 10 15 Glu Ser Asp Gly Asn Arg Thr Gln Val Thr Glu Phe Val Leu Thr Gly 20 25 30 Leu Thr Asp His Pro Gly Leu Gln Val Pro Leu Phe Leu Val Phe Leu 35 40 45 Ile Ile Tyr Leu Thr Thr Met Val Gly Asn Leu Ala Leu Ile Phe Leu 50 55 60 Ile Trp Lys Asp Pro His Leu His Thr Pro Met Tyr Leu Leu Leu Gly 65 70 75 80

Page 1986

069269_0225_SL.TXT

Ser Leu Ala Phe Ala 85 Asp Ala Cys Ser Ser Ser Ser Val Thr Pro Arg 90 95 Met Leu Met Asp Phe Leu Ser Arg Asn His Met Ile Ser Leu Val Glu 100 105 110 Cys Ile Thr Gln Phe Tyr Ile Phe Ala Ser Ser Ala Asn Thr Glu Cys 115 120 125 Phe Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 130 135 140 Pro Leu Leu Tyr Pro Val Val Met Ser Asn Ile Phe Cys Ile Gln Leu 145 150 155 160 Leu Ser Val Ser Tyr Ile Ile Gly Phe Leu His Pro Met Met His Val 165 170 175 Ser Leu Leu Cys Arg Leu Thr Phe Cys Lys Ser Asn Val Ile His Tyr 180 185 190 Phe Tyr Cys Glu Ile Leu Gln Leu Phe Lys Ile Ser Cys Thr Asp Pro 195 200 205 Arg Val Asn Met Leu Leu Ile Phe Ile Phe Ser Val Phe Ile Gln Phe 210 215 220 Phe Thr Phe Met Thr Ile Ile Ile Ser Tyr Ser Tyr Val Leu Phe Ala 225 230 235 240 Ile Leu Lys Lys Lys Ser Glu Lys Gly Arg Ser Lys Ala Phe Ser Thr 245 250 255 Cys Ser Ala His Leu Leu Ser Val Ser Leu Phe Tyr Gly Thr Leu Phe 260 265 270 Phe Met Tyr Val Arg Pro Gly Ser Gly Pro Ala Glu Asn Gln Asp Lys 275 280 285

Page 1987

069269_0225_SL.TXT

Met Tyr Ser Val Phe Tyr Thr Ile Ile Ile Pro Leu Leu Asn Pro Phe 290 295 300 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Gly Ala Leu Arg Arg Ile 305 310 315 320 Ile Tyr Ile Asn Ser Ser 325

<210> 1771 <211> 930 <212> DNA <213> Canis familiaris <400> 1771

atggaaatta aaaatgcaac agaactggaa gcgtttgttc tcacaggact cacatatcaa 60 cccaagtggc aaattcctct gttcttggtg ttcttggtta tctatctcat caccattgtg 120 gggaaccttg gtctgattgc tctcatctgc aatgaccctc agctttacat ccccatgtac 180 ttattccttg gcagtctggc atttgtggat gcctggatat catccacagt gacccccaag 240 atgctggtca acttctttgc caagagctgg acgatttctc tctctgaatg catgatacag 300 ttttttttct ttacaactgg tgcaaccaca gaatgttttc tgctggcaac aatggcatat 360 gatcgctatg tggccatatg caagccttta ctttatccag tgattatgac caacagacta 420 tccatgcagc tgttagtttc ctcatttgtc ggtggctttc ttcatgccat aattcatgta 480 ggctttttat tcagattaac cttctgtaat actaacataa tacatcactt ttactgtgac 540 atcatgccat tatttaaaat ttcttgtatg gatccttcta ttaatattct catagtatat 600 attttttctg ggtcaattca gatgctcacc attctgattg ttcttatctc ttacacttta 660 gttctcttta taatcttaaa aaagaagtct ctacaaggca taaggaaagc cttctccacc 720 tgtggggccc atctcttatc tgtgtctttg tactatggcc ccctcctttt catgtatgtg 780 cgccctagat ctgcacaagc agatgatcaa gatatgatgg attctctgtt ttacactgtc 840 ataattcctg ttttaaatcc agttatttac agcctgagaa ataagaaagt catagattca 900 ctgagaaaaa tattaaagag aaatgcttag 930

Page 1988

069269_0225_SL.TXT <210> 1772 <211> 309 <212> PRT <213> Canis familiaris

<400> 1772 Phe Val Leu Thr 15 Gly Met 1 Glu Ile Lys Asn Ala 5 Thr Glu Leu Glu 10 Ala Leu Thr Tyr Gln Pro Lys Trp Gln Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 Val Ile Tyr Leu Ile Thr Ile Val Gly Asn Leu Gly Leu Ile Ala Leu 35 40 45 Ile Cys Asn Asp Pro Gln Leu Tyr Ile Pro Met Tyr Leu Phe Leu Gly 50 55 60 Ser Leu Ala Phe Val Asp Ala Trp Ile Ser Ser Thr Val Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Phe Ala Lys Ser Trp Thr Ile Ser Leu Ser Glu 85 90 95 Cys Met Ile Gln Phe Phe Phe Phe Thr Thr Gly Ala Thr Thr Glu Cys 100 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Pro Val Ile Met Thr Asn Arg Leu Ser Met Gln Leu 130 135 140 Leu Val Ser Ser Phe Val Gly Gly Phe Leu His Ala Ile Ile His Val 145 150 155 160 Gly Phe Leu Phe Arg Leu Thr Phe Cys Asn Thr Asn Ile Ile His His 165 170 175 Phe Tyr Cys Asp Ile Met Pro Leu Phe Lys Ile Ser Cys Met Asp Pro

Page 1989

180

069269_0225_SL.TXT 185 190

Ser Ile Asn Ile Leu Ile Val Tyr 195 200 Leu Thr 210 Ile Leu Ile Val Leu 215 Ile Ile 225 Leu Lys Lys Lys Ser 230 Leu Gln Cys Gly Ala His Leu 245 Leu Ser Val Phe Met Tyr Val 260 Arg Pro Arg Ser Met Asp Ser 275 Leu Phe Tyr Thr Val 280 Ile Tyr 290 Ser Leu Arg Asn Lys 295 Lys Leu Lys Arg Asn Ala

305

Ile Phe Ser Gly Ser 205 Ile Gln Met Ser Tyr Thr Leu 220 Val Leu Phe Ile Gly Ile Arg 235 Lys Ala Phe Ser Thr 240 Ser Leu 250 Tyr Tyr Gly Pro Leu 255 Leu Ala 265 Gln Ala Asp Asp Gln 270 Asp Met Ile Ile Pro Val Leu 285 Asn Pro Val Val Ile Asp Ser 300 Leu Arg Lys Ile

<210> 1773 <211> 930 <212> DNA <213> Canis familiaris <400> 1773 atggaaaagg aaaatgcaac attgctgatg ccacggtgga aaatccctct atttttgatg gggaaccttg gtctgattgc tctcatctgg ttgttccttg gcagtctggc atttgtggat atgctggtca gtttctttgc caaaagcaaa tttttttcct ttgcaatcag tgcaacgaca gagctgattc tcacaggact cacacatgaa ttcttggttt tctatcttct cactattgtg aatgatcctc agcttcacat ccccatgtac gcttggttat catccacagt gacccccaag acgatctctc tctctgaatg tatgatacag gaatgctttt tgctggcaac aatggcttat

120

180

240

300

360

Page 1990

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gatcgctatg tggccatatg caaaccatta acttatccag tgattatgtc caatacactc 420 tgcatccggc tgatactttt gtcattttta ggaggacttc ttcatgccat aattcacagt 480 tcttttttat tcagattaac cttctgcaat tctatcatag tacatcattt ttactgtgat 540 attataccat tgtttaagat ctcctgtact gatccttcta ttaattatct gatggtattt 600 attttctctg ggtcaataca agtcttcacc attttgactg ttcttgtctc ctacacacta 660 gtgctcttta caatattaag aaagaagtcg ctacaaggca taaaaaaagc cttctccacc 720 tgtggggccc atctcttttc tgtgtcttta tactatggcc ccctcctttt catgtatgtg 780 cgccctagat ctgcacaggc agatgatcaa gatatgatgg actctctatt ttacactgtc 840 ataattccag tgttaaatcc aatgatctat agcctgagaa ataagaaagt tatagattca 900 atgagaaaaa tgttaaagag acatgcttag 930

<210> 1774 <211> 309 <212> PRT <213> Canis familiaris <400> 1774

Met Glu 1 Lys Glu Asn 5 Ala Thr Leu Leu Met Glu Leu Ile Leu Thr Gly 10 15 Leu Thr His Glu Pro Arg Trp Lys Ile Pro Leu Phe Leu Met Phe Leu 20 25 30 Val Phe Tyr Leu Leu Thr Ile Val Gly Asn Leu Gly Leu Ile Ala Leu 35 40 45 Ile Trp Asn Asp Pro Gln Leu His Ile Pro Met Tyr Leu Phe Leu Gly 50 55 60 Ser Leu Ala Phe Val Asp Ala Trp Leu Ser Ser Thr Val Thr Pro Lys 65 70 75 80 Met Leu Val Ser Phe Phe Ala Lys Ser Lys Thr Ile Ser Leu Ser Glu 85 90 95

Page 1991

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Cys Met Ile Gln 100 Phe Phe Ser Phe Ala Ile Ser Ala Thr Thr Glu Cys 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Thr Tyr Pro Val Ile Met Ser Asn Thr Leu Cys Ile Arg Leu 130 135 140 Ile Leu Leu Ser Phe Leu Gly Gly Leu Leu His Ala Ile Ile His Ser 145 150 155 160 Ser Phe Leu Phe Arg Leu Thr Phe Cys Asn Ser Ile Ile Val His His 165 170 175 Phe Tyr Cys Asp Ile Ile Pro Leu Phe Lys Ile Ser Cys Thr Asp Pro 180 185 190 Ser Ile Asn Tyr Leu Met Val Phe Ile Phe Ser Gly Ser Ile Gln Val 195 200 205 Phe Thr Ile Leu Thr Val Leu Val Ser Tyr Thr Leu Val Leu Phe Thr 210 215 220 Ile Leu Arg Lys Lys Ser Leu Gln Gly Ile Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ala His Leu Phe Ser Val Ser Leu Tyr Tyr Gly Pro Leu Leu 245 250 255 Phe Met Tyr Val Arg Pro Arg Ser Ala Gln Ala Asp Asp Gln Asp Met 260 265 270 Met Asp Ser Leu Phe Tyr Thr Val Ile Ile Pro Val Leu Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Lys Val Ile Asp Ser Met Arg Lys Met 290 295 300

Page 1992

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Leu Lys Arg His Ala

305 <210> 1775 <211> 930 <212> DNA <213> Canis familiaris <400> 1775

atggaaaagg aaaatgcaac cttgttgaca gagctgattc tcacaggact cacatatgaa 60 ccacaatggc acattcccct gttcctggtg ttcttggtta tctatcttct caccattgtc 120 gggaaccttg gtctgattgc tctcatctgg aatgaccctc agcttcacat ccccatgtac 180 ttgtttcttg gcagtctggc acttgtggat gcttggatat catccacagt gacccccaag 240 atgctggtca acttctttgc caagagaaaa gtgatctctc tctctgaatg tatgatacag 300 tttttttcct ttgcaatcag tataacgacg gaatgctttt tgctggcaac aatggcttat 360 gatcgatatg tggccatatg caaaccatta ctttatccag tgattatgtc taatacactg 420 tgcatccggc tgttagtttt gtcactttta ggtggacttc tccatgccat aattcatagt 480 tcttttttat tcagattaac cttctgtgat tccatcatag tacatcactt ttattgtgac 540 attatacccc tgcttaagat cacctgtact gacccttcta ttaattatct gatagtattt 600 atttttgctg ggtcaataca gatgttcacc attctgatag ttcttgtctc ctacacacta 660 gtgctcttca caatattaag aaagaagtct ctacaaggca taaagaaagc cttctccacc 720 tgtggggccc atctcttttc tgtctccttg tactatggtg ctctggtctt catgtatgtg 780 cgtcccgtag ctgcacagtc agaagatcaa gatatgatgg actctctctt ttacaccatc 840 ataattcctt tcttaaaccc aattatctac agcttgagaa accagaaagt catagattca 900 ttgagaaaaa cattaaagag aaattcttag 930

<210> 1776 <211> 309 <212> PRT <213> Canis familiaris <400> 1776

Met Glu Lys Glu Asn Ala Thr Leu Leu Thr Glu Leu Ile Leu Thr Gly 1 5 10 15

Page 1993

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Leu Thr Tyr Glu 20 Pro Gln Trp His Ile Pro Leu Phe Leu Val Phe Leu 25 30 Val Ile Tyr Leu Leu Thr Ile Val Gly Asn Leu Gly Leu Ile Ala Leu 35 40 45 Ile Trp Asn Asp Pro Gln Leu His Ile Pro Met Tyr Leu Phe Leu Gly 50 55 60 Ser Leu Ala Leu Val Asp Ala Trp Ile Ser Ser Thr Val Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Phe Ala Lys Arg Lys Val Ile Ser Leu Ser Glu 85 90 95 Cys Met Ile Gln Phe Phe Ser Phe Ala Ile Ser Ile Thr Thr Glu Cys 100 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Pro Val Ile Met Ser Asn Thr Leu Cys Ile Arg Leu 130 135 140 Leu Val Leu Ser Leu Leu Gly Gly Leu Leu His Ala Ile Ile His Ser 145 150 155 160 Ser Phe Leu Phe Arg Leu Thr Phe Cys Asp Ser Ile Ile Val His His 165 170 175 Phe Tyr Cys Asp Ile Ile Pro Leu Leu Lys Ile Thr Cys Thr Asp Pro 180 185 190 Ser Ile Asn Tyr Leu Ile Val Phe Ile Phe Ala Gly Ser Ile Gln Met 195 200 205 Phe Thr Ile Leu Ile Val Leu Val Ser Tyr Thr Leu Val Leu Phe Thr 210 215 220

Page 1994

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Ile 225 Leu Arg Lys Lys Ser 230 Leu Gln Gly Ile Lys 235 Lys Ala Phe Ser Thr 240 Cys Gly Ala His Leu Phe Ser Val Ser Leu Tyr Tyr Gly Ala Leu Val 245 250 255 Phe Met Tyr Val Arg Pro Val Ala Ala Gln Ser Glu Asp Gln Asp Met 260 265 270 Met Asp Ser Leu Phe Tyr Thr Ile Ile Ile Pro Phe Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Lys Val Ile Asp Ser Leu Arg Lys Thr 290 295 300

Leu Lys Arg Asn Ser 305 <210> 1777 <211> 930 <212> DNA <213> Canis familiaris <400> 1777

atggaaaagg aaaatgcaac cttgttgaca gagctgattc tcacaggact cacatatgaa 60 ccacaatggc acattcccct gttcctggtg ttcttggtta tctatcttct caccattgtc 120 gggaaccttg gtctgattgc tctcatctgg aatgaccctc agcttcacat ccccatgtac 180 ttgttccttg gcagtctggc atttgtggat gcctgggtat catccacagt gacccccaag 240 atgctggtca acttctttgc caagagcaaa atgatctctc tctctgaatg tatgatacag 300 tttttttcct ttgcaataag tgcaacgacg gaatgctttt tgctggcaac aatggcttat 360 gatcgctatg tggccatatg caaaccatta acttatccag tgattatgtc caatacactc 420 tgcatccggc tgatactttt gtcattttta ggaggacttc ttcatgccat aattcacagt 480 tcttttttat tcagattaac cttctgcgat tccatcatag tacatcactt ttattgtgac 540 attatacccc tgcttaagat cacttgtact gatccttcta ttaattatct gatagtattt 600 atttttgctg ggtcaataca gatgttcacc attctgatag ttcttgtctc ctacacacta 660

Page 1995

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gtgctcttca caatattaag aaagaagtct ctacaaggca taaagaaagc cttctccacc 720 tgtggggccc atctcttatc tgtttccttg tactatagtg ctctggtctt catgtatgtg 780 cgtcccgtag ctgcacagtc agaagatcaa gatatgatag actctctctt ttacaccatc 840 ataattcctt tcttaaaccc aattatctac agcttgagaa accagaaagt catagattca 900 ttgagaaaaa cattaaagag aaattcttag 930

<210> 1778 <211> 309 <212> PRT <213> Canis familiaris <400> 1778

Met 1 Glu Lys Glu Asn Ala Thr Leu Leu Thr Glu Leu Ile Leu Thr Gly 5 10 15 Leu Thr Tyr Glu Pro Gln Trp His Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 Val Ile Tyr Leu Leu Thr Ile Val Gly Asn Leu Gly Leu Ile Ala Leu 35 40 45 Ile Trp Asn Asp Pro Gln Leu His Ile Pro Met Tyr Leu Phe Leu Gly 50 55 60 Ser Leu Ala Phe Val Asp Ala Trp Val Ser Ser Thr Val Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Phe Ala Lys Ser Lys Met Ile Ser Leu Ser Glu 85 90 95 Cys Met Ile Gln Phe Phe Ser Phe Ala Ile Ser Ala Thr Thr Glu Cys 100 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Thr Tyr Pro Val Ile Met Ser Asn Thr Leu Cys Ile Arg Leu

130 135 140

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Ile 145 Leu Leu Ser Phe Leu 150 Gly Gly Leu Leu His Ala Ile Ile His Ser 155 160 Ser Phe Leu Phe Arg Leu Thr Phe Cys Asp Ser Ile Ile Val His His 165 170 175 Phe Tyr Cys Asp Ile Ile Pro Leu Leu Lys Ile Thr Cys Thr Asp Pro 180 185 190 Ser Ile Asn Tyr Leu Ile Val Phe Ile Phe Ala Gly Ser Ile Gln Met 195 200 205 Phe Thr Ile Leu Ile Val Leu Val Ser Tyr Thr Leu Val Leu Phe Thr 210 215 220 Ile Leu Arg Lys Lys Ser Leu Gln Gly Ile Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr Tyr Ser Ala Leu Val 245 250 255 Phe Met Tyr Val Arg Pro Val Ala Ala Gln Ser Glu Asp Gln Asp Met 260 265 270 Ile Asp Ser Leu Phe Tyr Thr Ile Ile Ile Pro Phe Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Lys Val Ile Asp Ser Leu Arg Lys Thr 290 295 300 Leu Lys Arg Asn Ser

305 <210> 1779 <211> 930 <212> DNA <213> Canis familiaris <400> 1779

Page 1997

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atggatacta aaaatgcaac actgctgaca aagtttgttc tctcaggatt cacatatcaa 60 ccacagtggc aaatacccct gttcctggtg ttcttggtga tatacctcat caccattgtg 120 ggaaaccttg gactaactgc tctcatctgc aatgatcctc agcttcacat ccccatgtac 180 ttactccttg ggaatttagc ctttgtagat gcttggatat catccacagt gactcccaag 240 atgctggtca acttcctagg caagagtaac attatatctc tttctgaatg catgacacaa 300 ctgttttcct ttgtatttag tgcaaccaca gaatgttttc tcttggcaac aatggcatat 360 gatcgctatg tagccatatg caaaccttta ctttatccaa tgattatgac ctatagactt 420 tgcacctggc tgttagtctc atcatttgta tgtggctttc ttcattctat agttcatata 480 ggctttttat tcagattaac cttttgtaat tctaaaataa tacatcactt ttactgtgac 540 atcatgccat tatttaagat ttcctgtact gacacttcaa ttaatgttct gatagttttt 600 attttctctg ggtcaataca agtatttacc attctgattg ttctggtctc ttatacactt 660 gttctcttta caatcttaaa aaagaagtct ctacaaggca taaagaaagc cttttccacc 720 tgtggagccc atctcttatc tgtctcctta tactatggct ctcttctctt catgtatgtg 780 cgccctggat ctgcaaaatc ggatgatcaa gatatgatgg actctctatt ttacactatc 840 ataattcctt tgttaaatcc aattatctac agtttgagaa ataagaaagt tatagattca 900 ttgagaaaaa tgttaaagag aaatgtttag 930

<210> 1780 <211> 309 <212> PRT <213> Canis familiaris

<400> 1780 Met 1 Asp Thr Lys Asn Ala Thr Leu Leu Thr Lys Phe Val Leu Ser Gly 5 10 15 Phe Thr Tyr Gln Pro Gln Trp Gln Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 Val Ile Tyr Leu Ile Thr Ile Val Gly Asn Leu Gly Leu Thr Ala Leu 35 40 45 Ile Cys Asn Asp Pro Gln Leu His Ile Pro Met Tyr Leu Leu Leu Gly Page 1998

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50 55 60

Asn 65 Leu Ala Phe Val Asp Ala Trp Ile Ser Ser Thr Val Thr Pro Lys 70 75 80 Met Leu Val Asn Phe Leu Gly Lys Ser Asn Ile Ile Ser Leu Ser Glu 85 90 95 Cys Met Thr Gln Leu Phe Ser Phe Val Phe Ser Ala Thr Thr Glu Cys 100 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Pro Met Ile Met Thr Tyr Arg Leu Cys Thr Trp Leu 130 135 140 Leu Val Ser Ser Phe Val Cys Gly Phe Leu His Ser Ile Val His Ile 145 150 155 160 Gly Phe Leu Phe Arg Leu Thr Phe Cys Asn Ser Lys Ile Ile His His 165 170 175 Phe Tyr Cys Asp Ile Met Pro Leu Phe Lys Ile Ser Cys Thr Asp Thr 180 185 190 Ser Ile Asn Val Leu Ile Val Phe Ile Phe Ser Gly Ser Ile Gln Val 195 200 205 Phe Thr Ile Leu Ile Val Leu Val Ser Tyr Thr Leu Val Leu Phe Thr 210 215 220 Ile Leu Lys Lys Lys Ser Leu Gln Gly Ile Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr Tyr Gly Ser Leu Leu 245 250 255 Phe Met Tyr Val Arg Pro Gly Ser Ala Lys Ser Asp Asp Gln Asp Met

Page 1999

260

069269_0225_SL.TXT 265 270

Met Asp Ser Leu Phe Tyr Thr Ile Ile Ile Pro Leu Leu Asn Pro Ile 275 280 285

Ile Tyr Ser Leu Arg Asn Lys Lys Val Ile Asp Ser Leu Arg Lys Met 290 295 300

Leu Lys Arg Asn Val 305 <210> 1781 <211> 942 <212> DNA <213> Canis familiaris <400> 1781

atgaaccagg taaatgaaag catcccacag gagttcatcc tcttaggttt ctcagatcga 60 ccatggctag agctcccact ctttgtggtc ttcctggttt cctatatctt gactatcttt 120 ggcaatctga caataattct tgtgtcttat ctggacccca aactccatac ccctatgtac 180 ttttttctta ccaatctgtc gctcctggac ctttgctata ccacaagtac agttccacag 240 atgctggtaa acatatgcag caccaggaag gtgattagtt atggtggctg tgtggcccag 300 ctcttcattt tcctggcctt gggttccact gaatgtcttc tcttggctgt catgtctttt 360 gataggtttg tagctatttg tcggcctctc tattactcag ttatcatgca ccaaaggctg 420 tgcctccagc tggcggctgc atcctggctc agtggctttg gcaactcagt gttgcaatcc 480 acctggaccc ttcagatgcc tctctgtggc catagagaag tagatcactt cttttgtgaa 540 gtccctgctc tgctcaagtt gtcctgtgta gacacaacag caaacgaggc tgaactattc 600 tttatcagtg tgctgttcct tctaatacct gtaacgttca tccttatatc ttatggtttt 660 attgtccaag cagtgttgag gattcagtca gccaaaggcc ggcgaaaagc gtttggcacc 720 tgtggctccc atctaattgt ggtgtcactg ttttatggca ctgctatcta catgtatctg 780 caaccaccat cacccaactc aaaggaccgg gggaagatgg tgtccctctt ctatggaatc 840 atcacaccca tgttgaaccc ccttatatac acactaagaa acaaagatgt aaagggagca 900 tttaggaggt tgattctgaa gatcttctta atcaagaaat ag 942

Page 2000

069269_0225_SL.TXT <210> 1782 <211> 313 <212> PRT <213> Canis familiaris

<400> 1782 Met 1 Asn Gln Val Asn 5 Glu Ser Ile Pro Gln Glu Phe Ile Leu Leu Gly 10 15 Phe Ser Asp Arg Pro Trp Leu Glu Leu Pro Leu Phe Val Val Phe Leu 20 25 30 Val Ser Tyr Ile Leu Thr Ile Phe Gly Asn Leu Thr Ile Ile Leu Val 35 40 45 Ser Tyr Leu Asp Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Leu Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro Gln 65 70 75 80 Met Leu Val Asn Ile Cys Ser Thr Arg Lys Val Ile Ser Tyr Gly Gly 85 90 95 Cys Val Ala Gln Leu Phe Ile Phe Leu Ala Leu Gly Ser Thr Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ser Phe Asp Arg Phe Val Ala Ile Cys Arg 115 120 125 Pro Leu Tyr Tyr Ser Val Ile Met His Gln Arg Leu Cys Leu Gln Leu 130 135 140 Ala Ala Ala Ser Trp Leu Ser Gly Phe Gly Asn Ser Val Leu Gln Ser 145 150 155 160 Thr Trp Thr Leu Gln Met Pro Leu Cys Gly His Arg Glu Val Asp His 165 170 175

Page 2001

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Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Val 190 Asp Thr 180 185 Thr Ala Asn Glu Ala Glu Leu Phe Phe Ile Ser Val Leu Phe Leu Leu 195 200 205 Ile Pro Val Thr Phe Ile Leu Ile Ser Tyr Gly Phe Ile Val Gln Ala 210 215 220 Val Leu Arg Ile Gln Ser Ala Lys Gly Arg Arg Lys Ala Phe Gly Thr 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Ile 245 250 255 Tyr Met Tyr Leu Gln Pro Pro Ser Pro Asn Ser Lys Asp Arg Gly Lys 260 265 270 Met Val Ser Leu Phe Tyr Gly Ile Ile Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly Ala Phe Arg Arg Leu 290 295 300 Ile Leu Lys Ile Phe Leu Ile Lys Lys

305 310 <210> 1783 <211> 945 <212> DNA <213> Canis familiaris <400> 1783 atggacacaa acaatggaag ttccacaaca gatttcatcc tcctggggtt ttctgattgg ccccaattag aacccatcat ttctggggtt gtcttcatct tctacattgt gactctggta ggaaacacaa ccatcattct tgtgtcttac ctagacaccc agctccatac tcccatgtat ttcttcttat ctaatttgtc ttttctggac ctctgttata caacaagcat tgccccccag atgctggtaa atctatgggg tccaacaaag tctattacct atgaagggtg tgtgcttcaa

120

180

240

300

Page 2002

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tcctttgttg cccttgacct gggatccaca gaatgtcttc tcttggctgt gatggcctat 360 gaccgctatg ctgctgtctg tcaacctctt cactacacag taataatgca ccctcagctt 420 tgccagaaga tggtgctcac tgcctggtta ggtggtcttg gcagtgcctt aattctctgc 480 tccttgactc tgaagttgcc aagatgtgga caccgagagg tggatcattt tttctgtgag 540 acgccagcat tgatcaagat ggcttgtgtc tattcaaaag taatggagat cactgtctat 600 gctcttggag tgatattact tctaatacct ctgtcactaa ttctcatctc atatgcagtt 660 atcactcaag ctgtcatgag gatcaagtca gcaacaaggt ggcataaggt cctcaataca 720 tgtggttccc acctcacagt agtaactctg ttttatggaa caatcattta catgtacatg 780 aaaccacata gtagcacatc ccaagataag gggaagttct ttactttctt ttacactatc 840 atcacaccca cccttaaccc tctaatctac actttaagaa acaaagatgt aaagagtgca 900 gtaaagagaa tactacatat agaagaatgg tcagcaaagt catga 945 <210> 1784 <211> 314 <212> PRT <213> Canis familiaris <400> 1784 Met Asp Thr Asn Asn Gly Ser Ser Thr Thr Asp Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asp Trp Pro Gln Leu Glu Pro Ile Ile Ser Gly Val Val Phe 20 25 30 Ile Phe Tyr Ile Val Thr Leu Val Gly Asn Thr Thr Ile Ile Leu Val 35 40 45 Ser Tyr Leu Asp Thr Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Ser Ile Ala Pro Gln 65 70 75 80 Met Leu Val Asn Leu Trp Gly Pro Thr Lys Ser Ile Thr Tyr Glu Gly 85 90 95

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Cys Val Leu Gln 100 Ser Phe Val Ala Leu Asp Leu Gly Ser Thr Glu Cys 105 110 Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Gln 115 120 125 Pro Leu His Tyr Thr Val Ile Met His Pro Gln Leu Cys Gln Lys Met 130 135 140 Val Leu Thr Ala Trp Leu Gly Gly Leu Gly Ser Ala Leu Ile Leu Cys 145 150 155 160 Ser Leu Thr Leu Lys Leu Pro Arg Cys Gly His Arg Glu Val Asp His 165 170 175 Phe Phe Cys Glu Thr Pro Ala Leu Ile Lys Met Ala Cys Val Tyr Ser 180 185 190 Lys Val Met Glu Ile Thr Val Tyr Ala Leu Gly Val Ile Leu Leu Leu 195 200 205 Ile Pro Leu Ser Leu Ile Leu Ile Ser Tyr Ala Val Ile Thr Gln Ala 210 215 220 Val Met Arg Ile Lys Ser Ala Thr Arg Trp His Lys Val Leu Asn Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Tyr Met Tyr Met Lys Pro His Ser Ser Thr Ser Gln Asp Lys Gly Lys 260 265 270 Phe Phe Thr Phe Phe Tyr Thr Ile Ile Thr Pro Thr Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Ser Ala Val Lys Arg Ile 290 295 300

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Leu His Ile Glu Glu Trp Ser Ala Lys Ser 305 310 <210> 1785 <211> 942 <212> DNA <213> Canis familiaris <400> 1785

atggaccaaa acaattatac ttctctacac ggttttgttt tacttggttt ctctgactat 60 cccaaactgg agatggtgct atcaggagtt gtcactgtct tttacttcat tacatgggtg 120 ggtaacacag ccatcatcat tgcatctctc ctggattcct gtctccatac accaatgtat 180 tttttcctca ggaatttatc tttcctggat ctatgcttca caaccagcat catccctcag 240 atgctggtta acttgtgggg acctgacaag accattagct atataggctg tgtcattcaa 300 ctctatattt atatgtggtt gggttccacc gaatgcctcc tcctagctgt tatgtcctat 360 gatcgcttca cagctatctg taagcctttg cattatttga taatcatgaa cccacatttc 420 tgtctcaaga taataatcac agtctggagc attagtttgg ccaattcggt agcattgtgt 480 acactcaccc tgaatttgcc tcgatgtgga aacaaccttc tggaccattt cctgtgtgag 540 ttgccagcta tagtcaaaat agcttgtata gacactacaa cagttgaaat gtctgttttt 600 gctttaggca ttgtctttgt ccttacaccc ctcagcctta ttcttctatc ctatggctac 660 attgccaaag ctgtgctgag aataaagtca aaagcaggcc gaaaaaaatc aatgaatact 720 tgtggatctc atctcactgt tgtgtccatc ttctatggaa ctataatcta catgtaccta 780 caaccaggta acagtgcctc cttagaccag ggcaagttcc tcaccctctt ttacacgatc 840 atcactccaa gtctgaatcc tctcatttat accctacgga ataaggacat gaagaatgca 900 ttgaggaagc tggtgagagt tgacatgaat ctacaaaatt ga 942

<210> 1786 <211> 313 <212> PRT <213> Canis familiaris <400> 1786

Met Asp Gln Asn Asn Tyr Thr Ser Leu His Gly Phe Val Leu Leu Gly 1 5 10 15

Page 2005

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Phe Ser Asp Tyr Pro 20 Lys Leu Glu Met Val Leu Ser Gly Val Val Thr 25 30 Val Phe Tyr Phe Ile Thr Trp Val Gly Asn Thr Ala Ile Ile Ile Ala 35 40 45 Ser Leu Leu Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Ile Ile Pro Gln 65 70 75 80 Met Leu Val Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Ile Gly 85 90 95 Cys Val Ile Gln Leu Tyr Ile Tyr Met Trp Leu Gly Ser Thr Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ser Tyr Asp Arg Phe Thr Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Ile Ile Met Asn Pro His Phe Cys Leu Lys Ile 130 135 140 Ile Ile Thr Val Trp Ser Ile Ser Leu Ala Asn Ser Val Ala Leu Cys 145 150 155 160 Thr Leu Thr Leu Asn Leu Pro Arg Cys Gly Asn Asn Leu Leu Asp His 165 170 175 Phe Leu Cys Glu Leu Pro Ala Ile Val Lys Ile Ala Cys Ile Asp Thr 180 185 190 Thr Thr Val Glu Met Ser Val Phe Ala Leu Gly Ile Val Phe Val Leu 195 200 205 Thr Pro Leu Ser Leu Ile Leu Leu Ser Tyr Gly Tyr Ile Ala Lys Ala 210 215 220

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Val 225 Leu Arg Ile Lys Ser 230 Lys Ala Cys Gly Ser His Leu 245 Thr Val Val Tyr Met Tyr Leu 260 Gln Pro Gly Asn Phe Leu Thr 275 Leu Phe Tyr Thr Ile 280 Ile Tyr 290 Thr Leu Arg Asn Lys 295 Asp Val 305 Arg Val Asp Met Asn 310 Leu Gln

Asn

Gly Arg Lys 235 Lys Ser Met Asn Thr 240 Ser Ile 250 Phe Tyr Gly Thr Ile 255 Ile Ser 265 Ala Ser Leu Asp Gln 270 Gly Lys Ile Thr Pro Ser Leu 285 Asn Pro Leu Met Lys Asn Ala 300 Leu Arg Lys Leu

<210> 1787 <211> 939 <212> DNA <213> Canis familiaris <400> 1787 atgagcacca acagctccgt ggtgaccgag ttcatccttg tgggcttctc ccatctggcc 60 aacctgcagg gctggctctt cacattcttc cttgccgtct atctgctcac cgtggcaggc 120 aacctcctca tagtgctgct ggtctccacg gattctgctc tccagtcccc catgtacttc 180 ttcctgcgca tgctgtcggc cctggagatc agctacacat ctgtcaccat gcccctgttg 240 ctgcaccacc tcctcacagg ccagcgccgc atacctcgct caggctgtgc tctccagatg 300 ttctttttcc ttttcttcgg tgccacagag tgttgcctcc tggctgccat ggcctatgac 360 cgctatgcag ccatctgcaa accccttcgc tacacacttc tgctgagtcc ccgggtgtgc 420 ctgcagctag cagggctggc atgggcctgt ggggcaatgg tgggcctggg ccacacctcc 480 ttcatcttct ccctgccctt ctgtggcccc aatgccatcc cacacttctt ttgtgagatc 540 cagcccatcc tgcagctggt atgtggagac acctcactca atgagctgca gattatccta 600

Page 2007

069269 0225 SL.TXT gctgctgccc ctggccacga tcctctcacc cctaaggcca acccccatcc aggcgaacat

tcatcatcct ctgtcccttc ggcctcatcc tgggctccta tgggcatatc 660 ttttccggat gccgtctgtt gctggccgcc gcaaggcctt ctccacctgc 720 tgctggtggt ctccctcttc tatggcacgg ccatcttcat ttacatccgc 780 gttataatcc agccactgac cctgtgctgt ctctcttcta tgctgtggtc 840 ttaatcccat catctatagc ctgcggaatg cggatgtcaa ggctgccctg 900 tccagaaaat gaagcctgcg gacacttga 939

<210> 1788 <211> 312 <212> PRT <213> Canis familiaris <400> 1788

Met Ser Thr Asn Ser Ser Val Val Thr Glu Phe Ile Leu Val Gly Phe 1 5 10 15

Ser His Leu Ala Asn Leu Gln Gly Trp Leu Phe Thr Phe Phe Leu Ala 20 25 30

Val Tyr Leu Leu Thr Val Ala Gly Asn Leu Leu Ile Val Leu Leu Val 35 40 45

Ser Thr Asp Ser Ala Leu Gln Ser Pro Met Tyr Phe Phe Leu Arg Met 50 55 60

Leu Ser Ala Leu Glu Ile Ser Tyr Thr Ser Val Thr Met Pro Leu Leu 65 70 75 80

Leu His His Leu Leu Thr Gly Gln Arg Arg Ile Pro Arg Ser Gly Cys 85 90 95

Ala Leu Gln Met Phe Phe Phe Leu Phe Phe Gly Ala Thr Glu Cys Cys 100 105 110

Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Lys Pro 115 120 125

Leu Arg Tyr Thr Leu Leu Leu Ser Pro Arg Val Cys Leu Gln Leu Ala Page 2008

069269_0225_SL.TXT

130 135 140

Gly 145 Leu Ala Trp Ala Cys Gly Ala Met Val Gly Leu Gly His Thr Ser 150 155 160 Phe Ile Phe Ser Leu Pro Phe Cys Gly Pro Asn Ala Ile Pro His Phe 165 170 175 Phe Cys Glu Ile Gln Pro Ile Leu Gln Leu Val Cys Gly Asp Thr Ser 180 185 190 Leu Asn Glu Leu Gln Ile Ile Leu Ala Ala Ala Leu Ile Ile Leu Cys 195 200 205 Pro Phe Gly Leu Ile Leu Gly Ser Tyr Gly His Ile Leu Ala Thr Ile 210 215 220 Phe Arg Met Pro Ser Val Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Gly Thr Ala Ile Phe 245 250 255 Ile Tyr Ile Arg Pro Lys Ala Ser Tyr Asn Pro Ala Thr Asp Pro Val 260 265 270 Leu Ser Leu Phe Tyr Ala Val Val Thr Pro Ile Leu Asn Pro Ile Ile 275 280 285 Tyr Ser Leu Arg Asn Ala Asp Val Lys Ala Ala Leu Arg Arg Thr Phe 290 295 300 Gln Lys Met Lys Pro Ala Asp Thr

305 310 <210> 1789 <211> 819 <212> DNA <213> Canis familiaris

Page 2009

069269_0225_SL.TXT <400> 1789 gttgtgttgt tcctcactct ggtgagcaac accctcatca tcctgctgtc tgtgcgggac 60 ccaaggctcc actcctcgat gtactttttc ctctccaacc tgtccttctt ggacctgcgc 120 ttcaccacaa gctccgtccc ccagctgctg gtcaacctct gcagcccaaa gaccaccagc 180 ttccttggct gctctgttca gctcttcatc tttctgttcc tggggaccac agagtgcatc 240 cacctgaaca tgatggcctt tgacctctac atggccatat gccagcctct gcactatacc 300 atcatcatgc ccccgttgcc tgtgccggca gctggcgtcc atggcctggg ccatcagtct 360 gctggagtcg gtggtccaga caccacccac tctccacctg cccttgtgtc cccaccagca 420 gggggatgag ttcgtgtgtg aggtcccagc ttaatcagac tgtctggtgg ggacaccacc 480 tacaaccaga tccagatggc tgtcaccagc atcctcatcc tgctcatgcc catcggcctc 540 atcctggtct cttactgtgc cattgcccag gcagtgctga ggattaactc agccaaccgg 600 tggaggaaag catgtgggac ctgcttctcc cctctcgtgg tggtcaccct cttctacaga 660 tcagccatcg ctgtctacct ccagccccag aatgcctatg cccagaaagg ggcatagttc 720 ttctgtctgt tctgtgccgt gggcactgca gcaatgaacc ctcatttaca ccctgaaaac 780 caaggaggta aagagggctg tcagaaggtc gctggggaa 819 <210> 1790 <211> 142 <212> PRT <213> Canis familiaris <400> 1790

Val 1 Val Leu Phe Leu Thr 5 Leu Val Ser Asn Thr Leu Ile Ile Leu Leu 10 15 Ser Val Arg Asp Pro Arg Leu His Ser Ser Met Tyr Phe Phe Leu Ser 20 25 30 Asn Leu Ser Phe Leu Asp Leu Arg Phe Thr Thr Ser Ser Val Pro Gln 35 40 45 Leu Leu Val Asn Leu Cys Ser Pro Lys Thr Thr Ser Phe Leu Gly Cys 50 55 60

Page 2010

Ser 65 Val Gln Leu Phe Ile 70 Phe 069269_0225_SL.TXT Leu Phe Leu Gly Thr Thr 75 Glu Cys Ile 80 His Leu Asn Met Met Ala Phe Asp Leu Tyr Met Ala Ile Cys Gln Pro 85 90 95 Leu His Tyr Thr Ile Ile Met Pro Pro Leu Pro Val Pro Ala Ala Gly 100 105 110 Val His Gly Leu Gly His Gln Ser Ala Gly Val Gly Gly Pro Asp Thr 115 120 125 Thr His Ser Pro Pro Ala Leu Val Ser Pro Pro Ala Gly Gly 130 135 140

<210> 1791 <211> 792 <212> DNA <213> Canis familiaris <400> 1791

cttgtgggta ccaccctcat catcctgctg tccgtgcggg accccaggtc ccactctctg 60 atgtactttt tcctctccaa cctgtccttc ttggacctct gctttaccac aagctctatc 120 ccccagctgc tggtcaacct ctgcagccca aagaccacca gcttccttgg ctgctctgct 180 ctgctcttca tctttctgtt cctaggaacc acagagtgca tcctcctaac tgtgatagcc 240 tttgacctcc acatggccat ctgccagccc ctccgctata ttaccatcat ccacccctgc 300 ctgttgtctg gcctggggtc catggcctgg gccatcggtc ttctggagtc agtggtccag 360 ttgccaccca ctctctacct gcccttctgt ccacaccggc agggggatga tttcatgtgt 420 gaggtcccag ctctaatcag actgtctggt gggcacacca cctacaacga gatccagatg 480 gctgtcacca gcatcctcat cctgtttgtg tccgccagcc tcatcctggt ctcttactgt 540 gccattgccc gggcagtact gaggattaac tcaatcagtg gagaaaagca tttgggacct 600 gcttctcccc tctcgcggtg gtcacccttt tctacagatc agccgtcgct gtctacctcc 660 agccccagaa tgcctatgcc cagaaagggg catagttctt ctgtctgttc tgtgctgtgg 720 gcactgcaga actgaaccct catttacacc ctgaaaacca aggaggtaaa gagggctgtc 780

Page 2011

069269_0225_SL.TXT agaaggttgc tg

792 <210> 1792 <211> 244 <212> PRT <213> Canis familiaris

<400> 1792 Leu 1 Val Gly Thr Thr 5 Leu Ile Ile Leu Leu Ser Val Arg Asp Pro Arg 10 15 Ser His Ser Leu Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp 20 25 30 Leu Cys Phe Thr Thr Ser Ser Ile Pro Gln Leu Leu Val Asn Leu Cys 35 40 45 Ser Pro Lys Thr Thr Ser Phe Leu Gly Cys Ser Ala Leu Leu Phe Ile 50 55 60 Phe Leu Phe Leu Gly Thr Thr Glu Cys Ile Leu Leu Thr Val Ile Ala 65 70 75 80 Phe Asp Leu His Met Ala Ile Cys Gln Pro Leu Arg Tyr Ile Thr Ile 85 90 95 Ile His Pro Cys Leu Leu Ser Gly Leu Gly Ser Met Ala Trp Ala Ile 100 105 110 Gly Leu Leu Glu Ser Val Val Gln Leu Pro Pro Thr Leu Tyr Leu Pro 115 120 125 Phe Cys Pro His Arg Gln Gly Asp Asp Phe Met Cys Glu Val Pro Ala 130 135 140 Leu Ile Arg Leu Ser Gly Gly His Thr Thr Tyr Asn Glu Ile Gln Met 145 150 155 160 Ala Val Thr Ser Ile Leu Ile Leu Phe Val Ser Ala Ser Leu Ile Leu 165 170 175

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069269_0225_SL.TXT

Val Ser Tyr Cys Ala Ile Ala Arg Ala 185 Val Leu Arg Ile Asn 190 Ser Ile 180 Ser Gly Glu Lys His Leu Gly Pro Ala Ser Pro Leu Ser Arg Trp Ser 195 200 205 Pro Phe Ser Thr Asp Gln Pro Ser Leu Ser Thr Ser Ser Pro Arg Met 210 215 220 Pro Met Pro Arg Lys Gly His Ser Ser Ser Val Cys Ser Val Leu Trp 225 230 235 240

Ala Leu Gln Asn <210> 1793 <211> 774 <212> DNA <213> Canis familiaris <400> 1793

agcacggagg agcgcttcct cctgctggat ttctccaact ggcccgtgct gcagcccacc 60 cttcttcacc ctcatcctgc tctgctacct cttgacgctg gcccgcaact tgagcctcat 120 gctgctggcg gcgcactacc gcgcctgcac acacccatgt actacttcct gtgccacctg 180 gcacaggtga acacgggctt caccacgagc gtggcgcctg cgctgctggc tggcctctgt 240 ggcctggagc tgtgactgct gcgcgccggc ctggcccagc tgtgggatcc actgtgtgcc 300 tcctgctggc ggcaatggcg ctggaccaca tggcagccgt ggtccactca ctgcatcatg 360 cccccgctcg cctcgcctcc cctgttgtca cgcgctggac agagcctagt ggctgagtag 420 tctggccaac tcgggggcga agaccacact gctggccgcc cggcctctgt gagcgccctg 480 ctgtccgcca tcatcctggc ctcctatggc cccgtggccc gcgctgtctg gggcatcttg 540 ttgggggcgg ctgcaggaag gtaatggaca agtgaggatc ccaccgtctg cctcctctat 600 ggctcggcca tctacactta cctgcagccc acacagcgtt atgaccaggg ccagggcaag 660 ctcatttcac tcttctacat cgtggtcacc ccggcactca acctgcttat ctacaccctc 720 aggaacaagg aagtgaaaag gacagccagg aagctcctgg ggagtctagg gaca 774

Page 2013

069269_0225_SL.TXT <210> 1794 <211> 84 <212> PRT <213> Canis familiaris

<400> 1794 Ser Thr Glu Glu 1 Arg 5 Phe Leu Leu Leu Asp Phe Ser Asn Trp Pro Val 10 15 Leu Gln Pro Thr Leu Leu His Pro His Pro Ala Leu Leu Pro Leu Asp 20 25 30 Ala Gly Pro Gln Leu Glu Pro His Ala Ala Gly Gly Ala Leu Pro Arg 35 40 45 Leu His Thr Pro Met Tyr Tyr Phe Leu Cys His Leu Ala Gln Val Asn 50 55 60 Thr Gly Phe Thr Thr Ser Val Ala Pro Ala Leu Leu Ala Gly Leu Cys 65 70 75 80

Gly Leu Glu Leu <210> 1795 <211> 963 <212> DNA <213> Canis familiaris <400> 1795

atgaatgcca gctgttccct gtggcaggac aacagcctgt ctgtcaagca cttctcattc 60 gccaagttct ctgaggtcac tgaacagtgt ttccttttat tcaccctcat cctactcatg 120 tttttagcat ccctgacggg caacgccctc atagcccttg ccatctggac caacccggtc 180 ctctacacgc ccatgtactt cttcctggcc aacctatctg tcttagagat tggctacact 240 tgctcggtca tacccaagat gctgcagagc cttgtgagtg aggctcgggg catctccagg 300 gagggctgtg ctacacagat gtttttcttc acattatttg ctatcagcga atgctgtctt 360 ttggcagcca tggcttttga ccgctacact gccatatgct ccccactcca ctatgcaact 420

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069269_0225_SL.TXT

cgaatgagtc gtggtgtgtg ttcccagttg gctgtggttt catggggagt gggttgcatt 480 gtaggtttgg gccagaccaa ctatattttc tccttgaact tctgtggccc ctgtgaaata 540 gatcacttct tttgtgacct cccacctatc ttggctcttg cctgtggcga tacatcccat 600 aatgaagttg cagtctttgt cgtggccatt ctttgcattt ccagcccgtt tttactaatc 660 gttgcttcct atggcagaat cctagctgct gttctgatca tgccctcacc cgaaggccgc 720 cgtaaagctc tttccacctg ttcttcccac ctgcttgtag tgacactctt ctatggctct 780 gggtctgtca cctacttgag acccaaggcc agccattcac caggaacaga taaactccta 840 gctctgttct acacagtggt gacatccatg ctcaatccta tcatctacag tttacggaac 900 aaggaggtca aggcagctct ctggagaacc ctgggtagaa aaaatgtttt gactcgtggg 960 tag 963 <210> 1796 <211> 320 <212> PRT <213> Canis familiaris <400> 1796 Met Asn Ala Ser Cys Ser Leu Trp Gln Asp Asn Ser Leu Ser Val Lys 1 5 10 15 His Phe Ser Phe Ala Lys Phe Ser Glu Val Thr Glu Gln Cys Phe Leu 20 25 30 Leu Phe Thr Leu Ile Leu Leu Met Phe Leu Ala Ser Leu Thr Gly Asn 35 40 45 Ala Leu Ile Ala Leu Ala Ile Trp Thr Asn Pro Val Leu Tyr Thr Pro 50 55 60 Met Tyr Phe Phe Leu Ala Asn Leu Ser Val Leu Glu Ile Gly Tyr Thr 65 70 75 80 Cys Ser Val Ile Pro Lys Met Leu Gln Ser Leu Val Ser Glu Ala Arg 85 90 95 Gly Ile Ser Arg Glu Gly Cys Ala Thr Gln Met Phe Phe Phe Thr Leu

Page 2015

100

069269_0225_SL.TXT 105 110

Phe Ala Ile 115 Ser Glu Cys Cys Leu Leu Ala Ala Met Ala Phe Asp Arg 120 125 Tyr Thr Ala Ile Cys Ser Pro Leu His Tyr Ala Thr Arg Met Ser Arg 130 135 140 Gly Val Cys Ser Gln Leu Ala Val Val Ser Trp Gly Val Gly Cys Ile 145 150 155 160 Val Gly Leu Gly Gln Thr Asn Tyr Ile Phe Ser Leu Asn Phe Cys Gly 165 170 175 Pro Cys Glu Ile Asp His Phe Phe Cys Asp Leu Pro Pro Ile Leu Ala 180 185 190 Leu Ala Cys Gly Asp Thr Ser His Asn Glu Val Ala Val Phe Val Val 195 200 205 Ala Ile Leu Cys Ile Ser Ser Pro Phe Leu Leu Ile Val Ala Ser Tyr 210 215 220 Gly Arg Ile Leu Ala Ala Val Leu Ile Met Pro Ser Pro Glu Gly Arg 225 230 235 240 Arg Lys Ala Leu Ser Thr Cys Ser Ser His Leu Leu Val Val Thr Leu 245 250 255 Phe Tyr Gly Ser Gly Ser Val Thr Tyr Leu Arg Pro Lys Ala Ser His 260 265 270 Ser Pro Gly Thr Asp Lys Leu Leu Ala Leu Phe Tyr Thr Val Val Thr 275 280 285 Ser Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys 290 295 300 Ala Ala Leu Trp Arg Thr Leu Gly Arg Lys Asn Val Leu Thr Arg Gly Page 2016

069269_0225_SL.TXT

305 310 315 320 <210> 1797 <211> 939 <212> DNA <213> Canis familiaris <400> 1797

atggagaatc acaacacaag ctcttttgaa ggcttcatcc tggtgggctt ctctgaccat 60 ccccacctag agctaatcct ctttgtggtc atcctcactt tttacgggct gactcttctt 120 ggcaatatga ccatcatctt actttctgct ctggattccc ggctgcacac accgatgtat 180 ttctttttgg ccaacctctc attcctggac ctgtgtttca ccatgggcac catccctcag 240 atgctctaca acctttgggg ctcagataag actatcagct atctgggttg tgccatccag 300 ctctacttcg tcctggctct aggaggggtg gagtgtgtcc tcctggctgt gatggcgtat 360 gaccgctatg ctgcaatctg cagacccctg cactacacag tcatcatgca cccccgactc 420 tgtgggcagc tggcttcagt ggcatggttg agtggctttg gcaattctct cataatggca 480 ccccagacat tgatgctacc ccgctgtggg cacaggcggg tgaaccactt tctctgtgag 540 atgccagcac taattggcat ggcctgtgta gataccatga gcctcgaggc actggcattt 600 gccttggcca tctttatcat cctgacacca ctcatcctca tcctcatctc ttatgggtat 660 attgcacgag cggtatttag gatcaagtca gctacagggc gaaagaaagc ctttaacacg 720 tgcagctccc acctaattgt tgtctctctc ttctatggca caatcatata catgtacctc 780 cagccagcaa acacttattc ccagcaccag ggcaagttcc tcactctctt ctacacaatc 840 gtcactccca gtgttaaccc cctgatctac acactgagaa acaaggatgt taaagaagcc 900 atgaagaagg tgctagggaa ggggggtaca gaagtatag 939

<210> 1798 <211> 312 <212> PRT <213> Canis familiaris <400> 1798

Met Glu Asn His Asn Thr Ser Ser Phe Glu Gly Phe Ile Leu Val Gly 1 5 10 15

Page 2017

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Phe Ser Asp His Pro 20 His Leu Glu Leu Ile Leu Phe Val Val Ile Leu 25 30 Thr Phe Tyr Gly Leu Thr Leu Leu Gly Asn Met Thr Ile Ile Leu Leu 35 40 45 Ser Ala Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Thr Met Gly Thr Ile Pro Gln 65 70 75 80 Met Leu Tyr Asn Leu Trp Gly Ser Asp Lys Thr Ile Ser Tyr Leu Gly 85 90 95 Cys Ala Ile Gln Leu Tyr Phe Val Leu Ala Leu Gly Gly Val Glu Cys 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Thr Val Ile Met His Pro Arg Leu Cys Gly Gln Leu 130 135 140 Ala Ser Val Ala Trp Leu Ser Gly Phe Gly Asn Ser Leu Ile Met Ala 145 150 155 160 Pro Gln Thr Leu Met Leu Pro Arg Cys Gly His Arg Arg Val Asn His 165 170 175 Phe Leu Cys Glu Met Pro Ala Leu Ile Gly Met Ala Cys Val Asp Thr 180 185 190 Met Ser Leu Glu Ala Leu Ala Phe Ala Leu Ala Ile Phe Ile Ile Leu 195 200 205 Thr Pro Leu Ile Leu Ile Leu Ile Ser Tyr Gly Tyr Ile Ala Arg Ala 210 215 220

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Val 225 Phe Arg Ile Lys Ser Ala 230 Thr Gly Arg Lys Lys Ala Phe Asn Thr 235 240 Cys Ser Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Tyr Met Tyr Leu Gln Pro Ala Asn Thr Tyr Ser Gln His Gln Gly Lys 260 265 270 Phe Leu Thr Leu Phe Tyr Thr Ile Val Thr Pro Ser Val Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Glu Ala Met Lys Lys Val 290 295 300 Leu Gly Lys Gly Gly Thr Glu Val 305 310

<210> 1799 <211> 822 <212> DNA <213> Canis familiaris <400> 1799

ttcatcctct taagtttctc agatcaacca tggctaaagc tcccactctt tgtggtcttc 60 ttcatttctt acatagtgac tatctttggg aatctgacca ttattctagt gtcatggctg 120 aaccccaaac tccatacccc catgtactta tttcttgcca atctgtcact cctggacctt 180 agctacacca caagtacagt tccatagatg ctggtaaatt tatacagcac tagaaaggga 240 attagttacg gtaggtgtgg cccaactctt catgttgtgg cccaactctt catgtttcta 300 gctttggggg ccactaaatg tgttctggtg gctgtcatgt cctttgatag gtttgtggct 360 atctgtcagc ctctccatta ttcagttatc atgcaccaaa ggctgtgcct ccagctggca 420 gaggcagctg atcactttct ctgtgaagtc cctgctcttc tcaagttgtc ctgtgtagat 480 acgacagtaa atgagggtga actattcttt gtaagtgtgt tattctatct gatacccctg 540 acgctcatcc tttatcacat gcttttattg cacaagtagt gttgagaatc tagtctgctg 600 aagatagaca aaaagcattt gggacatgtg gtccccatct gattgtggtg tcactgttct 660

Page 2019

069269_0225_SL.TXT atggtacagc tatctccatg tacctgcaac caccatcact ccaaggaccg ggaagagatg 720 gtgtcccgct tctaagggat cattgcaccc atgctgaatc cccttatata cacacttagg 780 aataaagagg taaaggaggc ctttaaaagg ttaattgcca ga 822 <210> 1800 <211> 68 <212> PRT <213> Canis familiaris

<400> 1800 Leu Ser Phe Ser Asp Gln Pro Trp Leu Lys Leu Pro 15 Leu Phe 1 Ile Leu 5 10 Phe Val Val Phe Phe Ile Ser Tyr Ile Val Thr Ile Phe Gly Asn Leu 20 25 30 Thr Ile Ile Leu Val Ser Trp Leu Asn Pro Lys Leu His Thr Pro Met 35 40 45 Tyr Leu Phe Leu Ala Asn Leu Ser Leu Leu Asp Leu Ser Tyr Thr Thr 50 55 60

Ser Thr Val Pro 65 <210> 1801 <211> 930 <212> DNA <213> Canis familiaris <400> 1801

atggaaaaat ccaatggcag ctcagagtat ggttttattt tagtgggctt ctctgatcgt 60 cccaagctgg agctagtgct cttcatagta aattttattc tgtatacagt agctgtgttg 120 ggaaattcaa ccataatcct tgtgtgtata ttagactctc gacttcatac cccaatgtac 180 ttctttctgg ccaatctttc ctttctagat ctctgcttca gtactagttg tatcccacag 240 atgctggtga acctctgggg ccctgacaag accatcagct atgctggctg tgtggtccag 300 cttttctcct tcctttctgt ggggagcatt gagtgcatcc tcctggctgt gatggcctat 360 gaccgctatg ctgcagtctg caaacccctc cactatctgg tcattatgca cccccagctg 420

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tgtttacgac tggtggctgt ggcctggggg agcggactgg tcaatgccat cgtcatgtcc 480 ccactcacaa tgactcttcc cagatgtggc cggctccgga tcaatcactt cctctgtgaa 540 atgccagcac tgattaagat ggcttgtgtg gacgcccgtg cagtagaaat gctggccttt 600 acctttgcca ttctcatcgt cctcctgccc ctcgttctta ttctcctgtc ctatggctat 660 atcactgcag cagtgctgaa gatcaagtct gctgctggcc gctggaaggc attcaatacc 720 tgcagctccc acctcaccgt ggtctcctta ttctatggga gcatcattta tatgtacatg 780 cagccaggaa acagctcctc tcaggaccaa ggcaagtttc tcaccctctt ctacaaccta 840 gtgactccta tgttgaatcc actcatatac accttaagga ataaagaggt aaaaggggca 900 ctgaaaaagg ttttggggag gcaacaatga 930

<210> 1802 <211> 309 <212> PRT <213> Canis familiaris

<400> 1802 Gly Ser Ser Glu Tyr Gly Phe Ile Leu Val Gly Met Glu 1 Lys Ser Asn 5 10 15 Phe Ser Asp Arg Pro Lys Leu Glu Leu Val Leu Phe Ile Val Asn Phe 20 25 30 Ile Leu Tyr Thr Val Ala Val Leu Gly Asn Ser Thr Ile Ile Leu Val 35 40 45 Cys Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Ser Thr Ser Cys Ile Pro Gln 65 70 75 80 Met Leu Val Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Val Val Gln Leu Phe Ser Phe Leu Ser Val Gly Ser Ile Glu Cys 100 105 110

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Ile Leu Leu 115 Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys 120 125 Pro Leu His Tyr Leu Val Ile Met His Pro Gln Leu Cys Leu Arg Leu 130 135 140 Val Ala Val Ala Trp Gly Ser Gly Leu Val Asn Ala Ile Val Met Ser 145 150 155 160 Pro Leu Thr Met Thr Leu Pro Arg Cys Gly Arg Leu Arg Ile Asn His 165 170 175 Phe Leu Cys Glu Met Pro Ala Leu Ile Lys Met Ala Cys Val Asp Ala 180 185 190 Arg Ala Val Glu Met Leu Ala Phe Thr Phe Ala Ile Leu Ile Val Leu 195 200 205 Leu Pro Leu Val Leu Ile Leu Leu Ser Tyr Gly Tyr Ile Thr Ala Ala 210 215 220 Val Leu Lys Ile Lys Ser Ala Ala Gly Arg Trp Lys Ala Phe Asn Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Ser Ile Ile 245 250 255 Tyr Met Tyr Met Gln Pro Gly Asn Ser Ser Ser Gln Asp Gln Gly Lys 260 265 270 Phe Leu Thr Leu Phe Tyr Asn Leu Val Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Gly Ala Leu Lys Lys Val 290 295 300 Leu Gly Arg Gln Gln

305

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069269_0225_SL.TXT <210> 1803 <211> 321 <212> DNA <213> Canis familiaris <400> 1803

aaagtgggag atagtaaggt gaaacatttc ctatgtgaaa ttgcctgtgt ggacaccgtg 60 gctgtggaaa gcactgtttt cttcttatca gtaatgattg tcctgcagcc cctggcactc 120 atcctggtct cctatggcta cattgtcctg gtggtgctga gcatgaagtc agctatggga 180 agaaggaaaa ctttcaacac atgtgggtcc cacttcactg tgatcttgtt ttatgggaat 240 attatctata agtatatgca gccagaaaat aattcttctc agaaccaaag aaatttctca 300 gaaattcctt accctcttct a 321

<210> 1804 <211> 107 <212> PRT <213> Canis familiaris <400> 1804

Lys Val Gly Asp Ser Lys Val Lys His Phe Leu Cys Glu Ile Ala Cys 1 5 10 15 Val Asp Thr Val Ala Val Glu Ser Thr Val Phe Phe Leu Ser Val Met 20 25 30 Ile Val Leu Gln Pro Leu Ala Leu Ile Leu Val Ser Tyr Gly Tyr Ile 35 40 45 Val Leu Val Val Leu Ser Met Lys Ser Ala Met Gly Arg Arg Lys Thr 50 55 60 Phe Asn Thr Cys Gly Ser His Phe Thr Val Ile Leu Phe Tyr Gly Asn 65 70 75 80 Ile Ile Tyr Lys Tyr Met Gln Pro Glu Asn Asn Ser Ser Gln Asn Gln 85 90 95 Arg Asn Phe Ser Glu Ile Pro Tyr Pro Leu Leu

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069269_0225_SL.TXT

105 <210> 1805 <211> 978 <212> DNA <213> Canis familiaris <400> 1805

atggagtcct ccttcttgca caggcagagt gcaagagaaa gagctaatga cagcaccttc 60 tcaggattcc ttcttctagg attctccaac aggcctcagt tggagacgcc tctctttgtg 120 ctcatcctga tcgtttactt cttgagcttt cttggcaatg gcaccatcat ccttctgtct 180 tggatggacc ctcgcctgca cacccccatg tatttcttcc tgtccaacct ctctttcatg 240 gatctttgtt tgaccacctg cacggtgcct cagacgctgg ccaacctcca ggggcgggtc 300 aagaccatca cgtatggtgg ctgtgtgacc cagctcttca tcgccctggg gcttgggggc 360 gtggagtgtg tgctcctggc cgtcatggcc tatgaccgct atgccgccgt gtgccgccca 420 ctgcactacc tggccatcgt gcacccgcag ctttgcctgt ggctggtgct aactgcttgg 480 ttcacaggat tcggcaactc tgtgctacaa acggctctga ccatgattct tcccctgtgt 540 gggagaaacc agctggacca tttcttctgt gaagttccgg tgatgctgaa gctctcctgt 600 gccgacacct ccttcaacca ggctgaactc ttcacggtca gcgtcttctt cctcgttgtg 660 cccctgtctc tcatcttact gtcctatggc cacatcaccc gggcagtcct gaagataaag 720 tcagcccagg ggaggcagaa ggcctttgga acctgtggtt cccacctcat ggtggtggtc 780 atcttctttg gcacactcat ctcaatgtac ctccagcctc cctccagtta ttcacaggat 840 gtgaacaaga gcattgcact cttctacaca ctggtcactc ccctgctgaa tcccctcatt 900 tatactctga gaaacaaaga ggtcaaaggg gcactgagga gactgctgag ggtgaccatg 960 gactccagaa ggagctaa 978

<210> 1806 <211> 325 <212> PRT <213> Canis familiaris <400> 1806

Met Glu Ser Ser Phe Leu His Arg Gln Ser Ala Arg Glu Arg Ala Asn 1 5 10 15

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Asp Ser Thr Phe 20 Ser Gly Phe Leu Leu Leu Gly Phe Ser Asn Arg Pro 25 30 Gln Leu Glu Thr Pro Leu Phe Val Leu Ile Leu Ile Val Tyr Phe Leu 35 40 45 Ser Phe Leu Gly Asn Gly Thr Ile Ile Leu Leu Ser Trp Met Asp Pro 50 55 60 Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Met 65 70 75 80 Asp Leu Cys Leu Thr Thr Cys Thr Val Pro Gln Thr Leu Ala Asn Leu 85 90 95 Gln Gly Arg Val Lys Thr Ile Thr Tyr Gly Gly Cys Val Thr Gln Leu 100 105 110 Phe Ile Ala Leu Gly Leu Gly Gly Val Glu Cys Val Leu Leu Ala Val 115 120 125 Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Arg Pro Leu His Tyr Leu 130 135 140 Ala Ile Val His Pro Gln Leu Cys Leu Trp Leu Val Leu Thr Ala Trp 145 150 155 160 Phe Thr Gly Phe Gly Asn Ser Val Leu Gln Thr Ala Leu Thr Met Ile 165 170 175 Leu Pro Leu Cys Gly Arg Asn Gln Leu Asp His Phe Phe Cys Glu Val 180 185 190 Pro Val Met Leu Lys Leu Ser Cys Ala Asp Thr Ser Phe Asn Gln Ala 195 200 205 Glu Leu Phe Thr Val Ser Val Phe Phe Leu Val Val Pro Leu Ser Leu 210 215 220

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Ile Leu Leu Ser Tyr Gly His Ile Thr Arg Ala Val Leu Lys Ile Lys 225 230 235 240 Ser Ala Gln Gly Arg Gln Lys Ala Phe Gly Thr Cys Gly Ser His Leu 245 250 255 Met Val Val Val Ile Phe Phe Gly Thr Leu Ile Ser Met Tyr Leu Gln 260 265 270 Pro Pro Ser Ser Tyr Ser Gln Asp Val Asn Lys Ser Ile Ala Leu Phe 275 280 285 Tyr Thr Leu Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 290 295 300 Asn Lys Glu Val Lys Gly Ala Leu Arg Arg Leu Leu Arg Val Thr Met 305 310 315 320 Asp Ser Arg Arg Ser

325 <210> 1807 <211> 975 <212> DNA <213> Canis familiaris <400> 1807

atgtgctacc agaggatgga acagaacaat ggtagttctt tcactgggtt tatcctgctg 60 ggtttctctg agcggcctca actggagcta gtcctctttg tggttcttct gatcttctat 120 atgtttactc tgctgggaaa cacaaccatc attgccttgt cccacctgga cccacttctt 180 cagactccca tgtacttttt cctctccaac ctaagctttc tggacttgtg ttacacgacc 240 agcactgtcc ctcagctcct ggttcatctc aggagagcag acaagtctat ctcctttggt 300 ggctgtgtag ttcagctctt catatcccta gggttgggat ccacagaatg cattctccta 360 ggggtcatgg cacttgaccg ctttgcagct gtctgcaggc ccctgcacta cacagtgatc 420 atgcattccc gtctctgtgt cctgatggct tctgcatcat ggttcattgg ttttgccaac 480

Page 2026

069269_0225_SL.TXT

tcctcattgc agacagtgct catcttcctt gtaccacttt gtgggagaaa taaaatagat 540 catttctttt gtgagatccc cccactgctc aatcttgcct gcgttgacac cactatatat 600 gagtctgaga tcttctttgt cagtgtgatc attctcttta tacctgtgac attaatcacc 660 gtctcctatg gttggattgt cagggcaatc tttagaataa aatcatctgc agggcaaagg 720 aaagcatttg ggacatgtgg gtcccacctc acagtggtct ccctgttcta tggtacagcc 780 atctacgctt acctccagcc cagcaacaac tattcccagg atcagggcaa gttcatttct 840 ctcttctaca ccatcatcac ccccatggtc aatcctgtca tatatacact gaggaacaag 900 gatgtgactg gagcaatgaa gaaggtgctt tggcgagtcc taactccaga tgactgggtg 960 ggaaagaccc tttga 975

<210> 1808 <211> 324 <212> PRT <213> Canis familiaris <400> 1808

Met Cys Tyr Gln Arg Met Glu Gln Asn Asn Gly Ser Ser Phe Thr Gly 1 5 10 15 Phe Ile Leu Leu Gly Phe Ser Glu Arg Pro Gln Leu Glu Leu Val Leu 20 25 30 Phe Val Val Leu Leu Ile Phe Tyr Met Phe Thr Leu Leu Gly Asn Thr 35 40 45 Thr Ile Ile Ala Leu Ser His Leu Asp Pro Leu Leu Gln Thr Pro Met 50 55 60 Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr 65 70 75 80 Ser Thr Val Pro Gln Leu Leu Val His Leu Arg Arg Ala Asp Lys Ser 85 90 95 Ile Ser Phe Gly Gly Cys Val Val Gln Leu Phe Ile Ser Leu Gly Leu 100 105 110

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Gly Ser Thr 115 Glu Cys Ile Leu Leu Gly Val Met Ala Leu Asp Arg Phe 120 125 Ala Ala Val Cys Arg Pro Leu His Tyr Thr Val Ile Met His Ser Arg 130 135 140 Leu Cys Val Leu Met Ala Ser Ala Ser Trp Phe Ile Gly Phe Ala Asn 145 150 155 160 Ser Ser Leu Gln Thr Val Leu Ile Phe Leu Val Pro Leu Cys Gly Arg 165 170 175 Asn Lys Ile Asp His Phe Phe Cys Glu Ile Pro Pro Leu Leu Asn Leu 180 185 190 Ala Cys Val Asp Thr Thr Ile Tyr Glu Ser Glu Ile Phe Phe Val Ser 195 200 205 Val Ile Ile Leu Phe Ile Pro Val Thr Leu Ile Thr Val Ser Tyr Gly 210 215 220 Trp Ile Val Arg Ala Ile Phe Arg Ile Lys Ser Ser Ala Gly Gln Arg 225 230 235 240 Lys Ala Phe Gly Thr Cys Gly Ser His Leu Thr Val Val Ser Leu Phe 245 250 255 Tyr Gly Thr Ala Ile Tyr Ala Tyr Leu Gln Pro Ser Asn Asn Tyr Ser 260 265 270 Gln Asp Gln Gly Lys Phe Ile Ser Leu Phe Tyr Thr Ile Ile Thr Pro 275 280 285 Met Val Asn Pro Val Ile Tyr Thr Leu Arg Asn Lys Asp Val Thr Gly 290 295 300 Ala Met Lys Lys Val Leu Trp Arg Val Leu Thr Pro Asp Asp Trp Val 305 310 315 320

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Gly Lys Thr Leu <210> 1809 <211> 753 <212> DNA <213> Canis familiaris <400> 1809

atagaaaaag gaaatcaaat cagtgtctct gactttcttc tcttgggctt ctcaagctgg 60 ccagagtgac aggctctcct tttcatactt ttcctgtgtc tctacttaac agggctgttt 120 ggaaacttgt tcatcttgct agctatcgtc tcagactgcc acctccacac acccatgtat 180 ttcttccttg ccaatctgtc tgtggtagac ctctgccttc cttcatctac agtccccaag 240 atgctgctga acatccaagc acagactcag accatctcct atcctggctg cctgggcaga 300 cagatgtatt tctgtatgat gtttgctaac atggacaaat tccttcccac agtgatggca 360 tatgaccgtt atgtggccat ctgtcaccct ttgtgttact ccaccattat gactcagcac 420 ctttgtgcct ctctggtgac tgtgcctggg ttctttgcca ctttgtatcc cttcttacac 480 acccttatgc tcacctgtct gcacttttgc tctaacatca cccaccattc cttctgtgat 540 aacaactctc tcctccccct ctcctgttct gacaccagtc tcaatcagtt catcgttctg 600 gctgcagtgg gattgatctt tgtggtacct tcagggtgta tcctgacatc ctatagcttc 660 atcatctcct ctgtgatgaa aatcccttct gcccaaggaa aactcagggc tttctccacc 720 tgtggatctc accttgcctt ggtcattctt ttt 753

<210> 1810 <211> 193 <212> PRT <213> Canis familiaris <400> 1810

Met Tyr Phe Phe Leu Ala Asn Leu Ser Val Val Asp Leu Cys Leu Pro 1 5 10 15

Ser Ser Thr Val Pro Lys Met Leu Leu Asn Ile Gln Ala Gln Thr Gln 20 25 30

Page 2029

Thr Ile Ser 35 Tyr Pro Gly Cys 069269_0225_SL.TXT Leu Gly Arg Gln Met Tyr 40 45 Phe Cys Met Met Phe Ala Asn Met Asp Lys Phe Leu Pro Thr Val Met Ala Tyr Asp 50 55 60 Arg Tyr Val Ala Ile Cys His Pro Leu Cys Tyr Ser Thr Ile Met Thr 65 70 75 80 Gln His Leu Cys Ala Ser Leu Val Thr Val Pro Gly Phe Phe Ala Thr 85 90 95 Leu Tyr Pro Phe Leu His Thr Leu Met Leu Thr Cys Leu His Phe Cys 100 105 110 Ser Asn Ile Thr His His Ser Phe Cys Asp Asn Asn Ser Leu Leu Pro 115 120 125 Leu Ser Cys Ser Asp Thr Ser Leu Asn Gln Phe Ile Val Leu Ala Ala 130 135 140 Val Gly Leu Ile Phe Val Val Pro Ser Gly Cys Ile Leu Thr Ser Tyr 145 150 155 160 Ser Phe Ile Ile Ser Ser Val Met Lys Ile Pro Ser Ala Gln Gly Lys 165 170 175 Leu Arg Ala Phe Ser Thr Cys Gly Ser His Leu Ala Leu Val Ile Leu 180 185 190

Phe <210> 1811 <211> 843 <212> DNA <213> Canis familiaris <400> 1811 ctacatgtgc acagttggaa aatattgcta ttattctggt ttctccacta gattcccaac

Page 2030

069269 0225 SL.TXT ttcaaagtcc tatgtatttc ttcctcatga aactgggata ccacaactgt atcccaaatg attatttata taggctgtat ggcccaggcc tgtgtcctgc ttggaatcat ggccttagac tctgtagtca tggaccacaa gcactgctgg ctggcaaatt cactgctgca gtccatactc gagctagacc acttcttttg tgagctgcct ataatcaaca aggttacttt agctgtggtg atgattcttg tcccttatag ttgtattgcc aagagactta atgccttcga cacttgttct ggccctggca tctacatcta tatgcagctt gttctaatgc tgttttactg tgttattact aggagcaagg atgttaaaga agctttgagg aga <210> 1812 <211> 78 <212> PRT <213> Canis familiaris gcctctcctt tttggatctc tgtttaccac ctattcaact tggtgggccc caacaagaac tatatattcc actggctagg ctgtactgaa tatgtggctg tgcttaagcc tctgaggtac cagctctcca gcactgcctg gctcaatggt atggtccagc tgcccctgtg tgggaaccag gtggttatta agatggttta tgtggacacc gccacctttc tgataatggg tcccctctcc caagccgtat ttcgaatccc ctctgttgat tcacgtttac tggtggtatc tttattttat ttgggggata gctttcaaga ccttaccaaa cctatggcca acccattcat ctacaccctg agacttctca gaagagcctt ttagtacaaa

120

180

240

300

360

420

480

540

600

660

720

780

840

843

<400> 1812 Thr Cys Ala Gln Leu Glu Asn Ile 1 5 Asp Ser Gln Leu Gln Ser Pro Met 20 Phe Leu Asp Leu Cys Leu Pro Gln 35 40 Asn Ala Ile Gln Leu Gly Gly Pro 50 55 Leu Tyr Gly Pro Gly Leu Tyr Ile

Ala Ile Ile Leu Val Ser Pro Leu 10 15 Tyr Phe Phe Leu Met Ser Leu Ser 25 30 Leu Gly Tyr His Asn Cys Ile Pro 45 Gln Gln Glu His Tyr Leu Tyr Arg 60 Pro Leu Ala Arg Leu Tyr 1 Page 203 1

069269_0225_SL.TXT <210> 1813 <211> 924 <212> DNA <213> Canis familiaris <400> 1813

atgcagggac acaacctcac agaggtgacc cagtttgttt tcctgggatt ctccagattt 60 cgtgaacatc agaccatcct gtttgtggtt ttcctcatcc tgtacacctt caccctggct 120 ggcaatgcca tcattgtgac cgtcgtctgc acggaccgcc acctgcacac gcccatgtac 180 gtcttcctga gcgtgctggc tggttcggag accgcgtaca cactggtcac cattccacgg 240 atgctgtctg gtctcctagc ccagaaccag cccatctcct cggcgggctg tgccacccag 300 atgttcttca tcgccttggc catcaacaac tgcttcctgc tcacggccat gggctacgac 360 cgctacgtgg ccatctgcga ccccctgcgg tacacggtcg tcatgagcaa gagggtgtgt 420 gtccagctga tgtgtggagt ctctggcatc ggccttgcca tggcagttgt ccaggtgacc 480 tccatattta ccttaccctt ctgtcacaga gtgattggac atttcttctg tgacatcctc 540 ccggtcctaa aactctcctg tattgatacc accgtcaatg agatcatcaa ttttgtcgtc 600 agttcatttg tgatcctggt ccccgtgggg ctggtcttcg tctcctacgt cctcatcatc 660 tccaccatcc tcaggatccg ctctgcccag ggccggaaga aggcctttgc cacctgcgcc 720 tcccacctca ccgtggtcat cgtccactac ggctgcgcct ccatcgccta cctcaagccc 780 aagtcggaga actccataga acaagacctc ctcctctcgg tgacttatac catcatcacg 840 cccctgctca accctgttgt ctacagccta aggaacaagg aggtcaaaga cgccctccgc 900 agagctgtgg gaagaaacat ctaa 924

<210> 1814 <211> 307 <212> PRT <213> Canis familiaris <400> 1814

Met Gln Gly His Asn Leu Thr Glu Val Thr Gln Phe Val Phe Leu Gly 1 5 10 15

Page 2032

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Phe Ser Arg Phe 20 Arg Glu His Gln Thr Ile Leu Phe Val Val Phe Leu 25 30 Ile Leu Tyr Thr Phe Thr Leu Ala Gly Asn Ala Ile Ile Val Thr Val 35 40 45 Val Cys Thr Asp Arg His Leu His Thr Pro Met Tyr Val Phe Leu Ser 50 55 60 Val Leu Ala Gly Ser Glu Thr Ala Tyr Thr Leu Val Thr Ile Pro Arg 65 70 75 80 Met Leu Ser Gly Leu Leu Ala Gln Asn Gln Pro Ile Ser Ser Ala Gly 85 90 95 Cys Ala Thr Gln Met Phe Phe Ile Ala Leu Ala Ile Asn Asn Cys Phe 100 105 110 Leu Leu Thr Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asp Pro 115 120 125 Leu Arg Tyr Thr Val Val Met Ser Lys Arg Val Cys Val Gln Leu Met 130 135 140 Cys Gly Val Ser Gly Ile Gly Leu Ala Met Ala Val Val Gln Val Thr 145 150 155 160 Ser Ile Phe Thr Leu Pro Phe Cys His Arg Val Ile Gly His Phe Phe 165 170 175 Cys Asp Ile Leu Pro Val Leu Lys Leu Ser Cys Ile Asp Thr Thr Val 180 185 190 Asn Glu Ile Ile Asn Phe Val Val Ser Ser Phe Val Ile Leu Val Pro 195 200 205 Val Gly Leu Val Phe Val Ser Tyr Val Leu Ile Ile Ser Thr Ile Leu 210 215 220

Page 2033

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Arg Ile 225 Arg Ser Ala Gln Gly Arg Lys Lys Ala Phe Ala Thr Cys Ala 230 235 240 Ser His Leu Thr Val Val Ile Val His Tyr Gly Cys Ala Ser Ile Ala 245 250 255 Tyr Leu Lys Pro Lys Ser Glu Asn Ser Ile Glu Gln Asp Leu Leu Leu 260 265 270 Ser Val Thr Tyr Thr Ile Ile Thr Pro Leu Leu Asn Pro Val Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Arg Arg Ala Val Gly 290 295 300 Arg Asn Ile

305 <210> 1815 <211> 945 <212> DNA <213> Canis familiaris <400> 1815

atggatcggc tgaaccgcac gtggccgcag accttcgttc tcacggggtt cggggccccc 60 gggcccgtgc ggccgctcgc cttcctggct accctgggcg tgtatgtcct cacactggcc 120 tcgaactcgt tcatcattgt gctggtgcag gcggatgcgg gcctgtccac gcccatgtac 180 ttcttcctcg gcgtgctctc cttcctggag gtctggtacg tcagcgccac ggtgcccacg 240 ctgctgctca cctggctccg cgggcgcccc cccatcccgg cggccggctg cttcctccag 300 ctgtacgccg tgcactccct gggcatgacg gagtgctccc tgctggccgt catggctctg 360 gaccgccacc tggccatctg ccgcccgctg cactaccccg cgctcatgag caggaaggcg 420 cagctggggc tggcgggggc cgcttgggtg gccggcttct cggcggccct ggtgccagcc 480 ggcctcacgg ccgccctgcc cttctgccgg aagcaggtgg cccactactt ttgtgacctg 540 gcccccctga tgaggttggc gtgtgtggac acggcctggc acgctcgagt gcacggggcg 600 gtgatcggtg tggccacggg ctgcaacttt gtgctgattt taggactgta cgggggtatc 660

Page 2034

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ctgagggcgg tgctgaagct gccctcggcc gccagccggg ccaaggcctt ctccacctgc 720 gcctcgcacg tgaccgtggt ggccctgttc tttggctctg cctttgttgt ctacgtgggg 780 ctgcccggga gtcaagccga gggcacagat aagtgtatcg ccttggtgta cacctttctg 840 acccccttcc tcaaccccat catctatacc cttcgcaaca aggaggtgag ggcggcggtg 900 aagagggtca ccatcagggt cggaactgct ctgaatcaac actga 945

<210> 1816 <211> 314 <212> PRT <213> Canis familiaris

<400> 1816 Leu Asn 5 Arg Thr Trp Pro Gln Thr Phe Val Leu Thr Gly Met 1 Asp Arg 10 15 Phe Gly Ala Pro Gly Pro Val Arg Pro Leu Ala Phe Leu Ala Thr Leu 20 25 30 Gly Val Tyr Val Leu Thr Leu Ala Ser Asn Ser Phe Ile Ile Val Leu 35 40 45 Val Gln Ala Asp Ala Gly Leu Ser Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Val Leu Ser Phe Leu Glu Val Trp Tyr Val Ser Ala Thr Val Pro Thr 65 70 75 80 Leu Leu Leu Thr Trp Leu Arg Gly Arg Pro Pro Ile Pro Ala Ala Gly 85 90 95 Cys Phe Leu Gln Leu Tyr Ala Val His Ser Leu Gly Met Thr Glu Cys 100 105 110 Ser Leu Leu Ala Val Met Ala Leu Asp Arg His Leu Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Pro Ala Leu Met Ser Arg Lys Ala Gln Leu Gly Leu 130 135 140

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Ala Gly Ala Ala Trp Val Ala Gly Phe Ser Ala Ala Leu Val Pro Ala 145 150 155 160 Gly Leu Thr Ala Ala Leu Pro Phe Cys Arg Lys Gln Val Ala His Tyr 165 170 175 Phe Cys Asp Leu Ala Pro Leu Met Arg Leu Ala Cys Val Asp Thr Ala 180 185 190 Trp His Ala Arg Val His Gly Ala Val Ile Gly Val Ala Thr Gly Cys 195 200 205 Asn Phe Val Leu Ile Leu Gly Leu Tyr Gly Gly Ile Leu Arg Ala Val 210 215 220 Leu Lys Leu Pro Ser Ala Ala Ser Arg Ala Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ser His Val Thr Val Val Ala Leu Phe Phe Gly Ser Ala Phe Val 245 250 255 Val Tyr Val Gly Leu Pro Gly Ser Gln Ala Glu Gly Thr Asp Lys Cys 260 265 270 Ile Ala Leu Val Tyr Thr Phe Leu Thr Pro Phe Leu Asn Pro Ile Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Glu Val Arg Ala Ala Val Lys Arg Val Thr 290 295 300 Ile Arg Val Gly Thr Ala Leu Asn Gln His 305 310

<210> 1817 <211> 945 <212> DNA <213> Canis familiaris <400> 1817 atggatcggc tgaaccgcac gtggccgcag accttcgttc tcacggggtt cggggccccc

Page 2036

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gggcccgtgc ggccactcgc cttcctggct accctgggcg tgtatgtcct cacactggcc 120 tcgaactcgt tcatcattgt gctggtgcag gcggatgcgg gcctgtccac gcccatgtac 180 ttcttcctcg gcgtgctctc cttcctggag gtctggtacg tcagcgccac ggtgcccacg 240 ctgctgctca cctggctccg cgggcgcccc cccatcccgg tggccggctg cttcctccag 300 ctatacgccg tgcactccct gggcatgacg gagtgctccc tgctggccgt catggctctg 360 gaccgccacc tggccatctg ccgcccgctg cactaccccg cgctcatgag caggaaggcg 420 cagctggggc tggcgggggc cgcttgggtg gccggcttct cggcggccct ggtgccagcc 480 ggcctcacgg ccgccctgcc cttctgccgg aagcaggtgg cccactactt ttgtgacctg 540 gcccccctga tgaggttggc gtgtgtggac acggcctggc acgctcgagt gcacggggca 600 gtgattggca tgatcaacac atgcaacttt gtgctgattt taggactgta cgggggtgtc 660 ctgagggcgg tgctgaagct gccctcggcc gccagccggg ccaaggcctt ctccacctgc 720 acctcgcacg tgaccgtggt ggccctgttc tttggctctg cctttgttgt ctatgtgggg 780 ctgcccggga gtcaagccga gggcacagat aagtgtatcg ccttggtgta cacccttctc 840 acccccttcc tcaaccccat catctatacc cttcgcaaca aggaggtgaa gagggctgtc 900 aggagggtca tccagcagat tagggccatt ttgaaaggac cctga 945

<210> 1818 <211> 314 <212> PRT <213> Canis familiaris <400> 1818

Met Asp Arg Leu Asn Arg Thr Trp Pro Gln Thr Phe Val Leu Thr Gly 1 5 10 15 Phe Gly Ala Pro Gly Pro Val Arg Pro Leu Ala Phe Leu Ala Thr Leu 20 25 30 Gly Val Tyr Val Leu Thr Leu Ala Ser Asn Ser Phe Ile Ile Val Leu 35 40 45 Val Gln Ala Asp Ala Gly Leu Ser Thr Pro Met Tyr Phe Phe Leu Gly

50 55 60

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Val 65 Leu Ser Phe Leu Glu Val Trp Tyr Val Ser Ala Thr Val Pro Thr 70 75 80 Leu Leu Leu Thr Trp Leu Arg Gly Arg Pro Pro Ile Pro Val Ala Gly 85 90 95 Cys Phe Leu Gln Leu Tyr Ala Val His Ser Leu Gly Met Thr Glu Cys 100 105 110 Ser Leu Leu Ala Val Met Ala Leu Asp Arg His Leu Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Pro Ala Leu Met Ser Arg Lys Ala Gln Leu Gly Leu 130 135 140 Ala Gly Ala Ala Trp Val Ala Gly Phe Ser Ala Ala Leu Val Pro Ala 145 150 155 160 Gly Leu Thr Ala Ala Leu Pro Phe Cys Arg Lys Gln Val Ala His Tyr 165 170 175 Phe Cys Asp Leu Ala Pro Leu Met Arg Leu Ala Cys Val Asp Thr Ala 180 185 190 Trp His Ala Arg Val His Gly Ala Val Ile Gly Met Ile Asn Thr Cys 195 200 205 Asn Phe Val Leu Ile Leu Gly Leu Tyr Gly Gly Val Leu Arg Ala Val 210 215 220 Leu Lys Leu Pro Ser Ala Ala Ser Arg Ala Lys Ala Phe Ser Thr Cys 225 230 235 240 Thr Ser His Val Thr Val Val Ala Leu Phe Phe Gly Ser Ala Phe Val 245 250 255 Val Tyr Val Gly Leu Pro Gly Ser Gln Ala Glu Gly Thr Asp Lys Cys 260 265 270

Page 2038

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Ile Ala Leu Val Tyr Thr Leu Leu Thr Pro Phe Leu Asn Pro Ile Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Glu Val Lys Arg Ala Val Arg Arg Val Ile 290 295 300 Gln Gln Ile Arg Ala Ile Leu Lys Gly Pro

305 310 <210> 1819 <211> 954 <212> DNA <213> Canis familiaris <400> 1819

atggaacggc acaaccgctc aagcctggtc gagttcgtgc tccttggttt ccccaaagtg 60 ggacacgtca gaggctggct ttttgtcctg ctgctgttgg catacctgtt cactatctgc 120 ggcaacatgc tcatcttctt agtcatacga ctggatgcag ccctgcacac acccatgtac 180 cactttgtca gtgtactctc cgtcttggag ctgtggtaca cggccactac catccccaag 240 atgctggcca atcttctcag tgagaagaag accatttctt ttgcaggatg cctccttcag 300 acctacttct tccactccct aggggcctct gaatgctacc ttcttacagc catggcctat 360 gaccggtatc tggccatctg ccggcccctc cactaccctg caattatgac gccaaccctc 420 tgtagcaaga tggctgctgg ctgttggact tgtggcttcc tgtgtcccat ttccgaagtc 480 atcctggtct cccggctccc cttctgtggc tacaatgaaa ttcaacacat cttctgtgac 540 tttccgcctc tgctgagcct ggcctgcaag gacacatcca ctaatgtcct tgtggacttt 600 gccatcaatg ccttcatcat cctaatcacc tttctcttta ttatggtttc ttatggaaga 660 atcattggtg ctgtactgaa gataaaaaca gcagcaggga gaaggaaggc cttctctaca 720 tgtgcctcgc atctcactgt ggttctcatc ttctttggga gcatcatctt catgtatgtg 780 cgcctaaaga agagctattc cctgaccctt gaccgaacac ttgctgttgt ctactctgta 840 ctgacgccac tggtcaaccc aattatctac agccttcgta acaaggaact cattaaggcc 900 atcaagagga ccgtcttccg gaaaggggag agagctagtc ctactcacca ctga 954

Page 2039

069269_0225_SL.TXT <210> 1820 <211> 317 <212> PRT <213> Canis familiaris

<400> 1820 Met 1 Glu Arg His Asn Arg 5 Ser Ser Leu Val 10 Glu Phe Val Leu Leu 15 Gly Phe Pro Lys Val Gly His Val Arg Gly Trp Leu Phe Val Leu Leu Leu 20 25 30 Leu Ala Tyr Leu Phe Thr Ile Cys Gly Asn Met Leu Ile Phe Leu Val 35 40 45 Ile Arg Leu Asp Ala Ala Leu His Thr Pro Met Tyr His Phe Val Ser 50 55 60 Val Leu Ser Val Leu Glu Leu Trp Tyr Thr Ala Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Ala Asn Leu Leu Ser Glu Lys Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Leu Leu Gln Thr Tyr Phe Phe His Ser Leu Gly Ala Ser Glu Cys 100 105 110 Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Pro Ala Ile Met Thr Pro Thr Leu Cys Ser Lys Met 130 135 140 Ala Ala Gly Cys Trp Thr Cys Gly Phe Leu Cys Pro Ile Ser Glu Val 145 150 155 160 Ile Leu Val Ser Arg Leu Pro Phe Cys Gly Tyr Asn Glu Ile Gln His 165 170 175 Ile Phe Cys Asp Phe Pro Pro Leu Leu Ser Leu Ala Cys Lys Asp Thr

Page 2040

180

069269_0225_SL.TXT 185 190

Ser Thr Asn Val Leu Val Asp Phe Ala Ile Asn Ala Phe Ile Ile Leu 195 200 205

Ile Thr Phe Leu Phe Ile Met Val Ser Tyr Gly Arg Ile Ile Gly Ala 210 215 220

Val Leu Lys Ile Lys Thr Ala Ala Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240

Cys Ala Ser His Leu Thr Val Val Leu Ile Phe Phe Gly Ser Ile Ile 245 250 255

Phe Met Tyr Val Arg Leu Lys Lys Ser Tyr Ser Leu Thr Leu Asp Arg 260 265 270

Thr Leu Ala Val Val Tyr Ser Val Leu Thr Pro Leu Val Asn Pro Ile 275 280 285

Ile Tyr Ser Leu Arg Asn Lys Glu Leu Ile Lys Ala Ile Lys Arg Thr 290 295 300

Val Phe Arg Lys Gly Glu Arg Ala Ser Pro Thr His His 305 310 315 <210> 1821 <211> 951 <212> DNA <213> Canis familiaris <400> 1821 atgagtggtg agccatggac ccccgggaac tggagctggg tgacagagtt catcatcttg ggctttcctc atgtccaggg ggtgcaggct tacctcttcg tcttgctact tctcatttac gtcaccaccg tcctgggaaa cctgctgata ttcctggtgg tgcgcctgga cccccggctc cacactccca tgtaccactt tgtcagcgcg ctctcgctgc tggagctcgg ctatacagcg gccaccatcc ccaagatgct gtcgaacctg ctcagcgagg agaagaccat ttccttctcc ggatgccttc tgcaaatcta tttctttcac tctcttgggg ctgctgagtg ctacctcctc Page 2041

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180

240

300

360

069269_0225_SL.TXT

acagccatgg cttatgacag gtacttagcc atctgccagc ctctccacta ccccaccctc 420 atgaccccgg cgctctgtgc ccggattgcc gttggctgtt ggttgggagg cctggctggg 480 ccggtggctg aaatttctct ggtgtcccgt ctccctttct gtggccccaa tcacattcag 540 cacatctttt gtgatttccc tcctgtgctg agcttggcct gtacagacac atctgtcaat 600 gtcctagtgg acttcgttat caactcctgc aaaatcctgg ccaccttcct gttgatcctc 660 agctcctatg tccagatcat ccgcacggta ctcaggattc cttcagttgc aggcaagaca 720 aaggccttct ccacctgtgc ctcccacctg accgtggttc tcatcttcta cgggagcatc 780 ctcttcatgt atgtgcggct gaagaagagc tactcgctgg actatgaccg cgcactggct 840 gtgatctact cggtgctcac gccttttctc aaccccttca tctacagctt gcgcaacaag 900 gatattaagg aggctgtgag gaggcagttg aggaggtcag ggatactgtg a 951

<210> 1822 <211> 316 <212> PRT <213> Canis familiaris

<400> 1822 Pro Trp 5 Thr Pro Gly Asn Trp Ser Trp Val Thr Glu Met Ser 1 Gly Glu 10 15 Phe Ile Ile Leu Gly Phe Pro His Val Gln Gly Val Gln Ala Tyr Leu 20 25 30 Phe Val Leu Leu Leu Leu Ile Tyr Val Thr Thr Val Leu Gly Asn Leu 35 40 45 Leu Ile Phe Leu Val Val Arg Leu Asp Pro Arg Leu His Thr Pro Met 50 55 60 Tyr His Phe Val Ser Ala Leu Ser Leu Leu Glu Leu Gly Tyr Thr Ala 65 70 75 80 Ala Thr Ile Pro Lys Met Leu Ser Asn Leu Leu Ser Glu Glu Lys Thr 85 90 95

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Ile Ser Phe Ser Gly 100 Cys Leu Leu Gln Ile Tyr Phe Phe His Ser Leu 105 110 Gly Ala Ala Glu Cys Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr 115 120 125 Leu Ala Ile Cys Gln Pro Leu His Tyr Pro Thr Leu Met Thr Pro Ala 130 135 140 Leu Cys Ala Arg Ile Ala Val Gly Cys Trp Leu Gly Gly Leu Ala Gly 145 150 155 160 Pro Val Ala Glu Ile Ser Leu Val Ser Arg Leu Pro Phe Cys Gly Pro 165 170 175 Asn His Ile Gln His Ile Phe Cys Asp Phe Pro Pro Val Leu Ser Leu 180 185 190 Ala Cys Thr Asp Thr Ser Val Asn Val Leu Val Asp Phe Val Ile Asn 195 200 205 Ser Cys Lys Ile Leu Ala Thr Phe Leu Leu Ile Leu Ser Ser Tyr Val 210 215 220 Gln Ile Ile Arg Thr Val Leu Arg Ile Pro Ser Val Ala Gly Lys Thr 225 230 235 240 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Leu Ile Phe 245 250 255 Tyr Gly Ser Ile Leu Phe Met Tyr Val Arg Leu Lys Lys Ser Tyr Ser 260 265 270 Leu Asp Tyr Asp Arg Ala Leu Ala Val Ile Tyr Ser Val Leu Thr Pro 275 280 285 Phe Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Glu 290 295 300

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Ala Val Arg Arg Gln Leu Arg Arg Ser Gly Ile Leu 305 310 315 <210> 1823 <211> 960 <212> DNA <213> Canis familiaris <400> 1823

atgacacggc tggagaccct ggggaatcag actatggtga ctgagttctt gttctctgtg 60 ttcccacctc tgcatcaagg tggcctcctg tttttcatcc ccctgcttct cgcctatgga 120 ttcatcatca ctgggaacct ggtgatagtc attgtggtcc agctggacat ggccctgcac 180 actcccatgt acttcttcat cagtgtcctc tccttcctgg aggtcgggta caccacgacc 240 accatcccca agatgctctc cagcctggtc aatgagcaga agaccatctc tctggccggc 300 tgcctcctgc agatgtactt cttccactcc ctgggcatca cggaaggctg tgtgctgaca 360 gcaatggcca ttgacaggta cgtcgccatc tgcagtcctc tccgttaccc gaccatcatg 420 actcccaagc tgtgcaccca gctaacagct gggtcctgcc tctgtggctt cctccttgtg 480 ctccctgaga tcgcgtggat tgccaccttg cctttctgtg gccccaaccg gatccagcag 540 atcttctgtg acttcacacc tgtgttgagc ttggcctgca cagacacatc gctggtggtc 600 atcgtggacg ctatccacgc agtggagatc gtggcctcct tcctggccat cgccctatcc 660 tacgtccgga tcatcgtggt gattctgggg atgccctctg ctgagggccg ccgcaaggcc 720 ttctccacct gtgccgctca ccttgctgtg ttcctgctct tcttcggcag tgtggctgtc 780 atgtatctgc ggttctcagc cacctactca gtgttttggg acacagcaat tgctgtcagc 840 tttgtaatcc ttgctccctt cctcaacccc attatctaca gcctgagaaa caaggacatg 900 aaagatgcta ttagaaggtt tttctgccgt cggaggaggg ctggtggggt cagggggtag 960

<210> 1824 <211> 319 <212> PRT <213> Canis familiaris <400> 1824

Met Thr Arg Leu Glu Thr Leu Gly Asn Gln Thr Met Val Thr Glu Phe 1 5 10 15

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Leu Phe Ser Val 20 Phe Pro Pro Leu His Gln Gly Gly Leu Leu Phe Phe 25 30 Ile Pro Leu Leu Leu Ala Tyr Gly Phe Ile Ile Thr Gly Asn Leu Val 35 40 45 Ile Val Ile Val Val Gln Leu Asp Met Ala Leu His Thr Pro Met Tyr 50 55 60 Phe Phe Ile Ser Val Leu Ser Phe Leu Glu Val Gly Tyr Thr Thr Thr 65 70 75 80 Thr Ile Pro Lys Met Leu Ser Ser Leu Val Asn Glu Gln Lys Thr Ile 85 90 95 Ser Leu Ala Gly Cys Leu Leu Gln Met Tyr Phe Phe His Ser Leu Gly 100 105 110 Ile Thr Glu Gly Cys Val Leu Thr Ala Met Ala Ile Asp Arg Tyr Val 115 120 125 Ala Ile Cys Ser Pro Leu Arg Tyr Pro Thr Ile Met Thr Pro Lys Leu 130 135 140 Cys Thr Gln Leu Thr Ala Gly Ser Cys Leu Cys Gly Phe Leu Leu Val 145 150 155 160 Leu Pro Glu Ile Ala Trp Ile Ala Thr Leu Pro Phe Cys Gly Pro Asn 165 170 175 Arg Ile Gln Gln Ile Phe Cys Asp Phe Thr Pro Val Leu Ser Leu Ala 180 185 190 Cys Thr Asp Thr Ser Leu Val Val Ile Val Asp Ala Ile His Ala Val 195 200 205 Glu Ile Val Ala Ser Phe Leu Ala Ile Ala Leu Ser Tyr Val Arg Ile 210 215 220

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Ile 225 Val Val Ile Leu Gly Met Pro Ser Ala Glu Gly Arg Arg Lys Ala 230 235 240 Phe Ser Thr Cys Ala Ala His Leu Ala Val Phe Leu Leu Phe Phe Gly 245 250 255 Ser Val Ala Val Met Tyr Leu Arg Phe Ser Ala Thr Tyr Ser Val Phe 260 265 270 Trp Asp Thr Ala Ile Ala Val Ser Phe Val Ile Leu Ala Pro Phe Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Ile 290 295 300 Arg Arg Phe Phe Cys Arg Arg Arg Arg Ala Gly Gly Val Arg Gly 305 310 315

<210> 1825 <211> 951 <212> DNA <213> Canis familiaris <400> 1825

atggatccgg agaatcagac aggggtggcc gagttctatt tctccgattt ccctccattt 60 gggaatggca gcctcttact cttcactcct ctgctcttta tttatgcgtt cattattgtg 120 ggaaacttca ccatcttctc tgctgtccgt ctggacaccc gcctccacaa ccccatgtac 180 aatctcatca gcgccttctc cttcctggag gtctggtaca ccacagccac catccccaag 240 atgctctcca acctggtcag tgagaagaag gccatctctt tcactggctg cctcctgcag 300 atgtatttct tccactcgct tggggtcaca gaagccctag tcctcacggt gatggccatc 360 gacaggtaca ttgccatctg caaccccctc cgctatgcaa tcattatgac ccctcggcta 420 tgtgtccagc tttccaccgg gtcttgcatc tttggcttcc ttatgctgct gccagagatt 480 gtgtggattt ctactcttcc cttctgtggc cccaaccaaa tccatcaact cttctgtgac 540 tttgaaccca tgctgcgctt ggcctgtaca gacacgtcca tgattctggt tgaagacgtg 600 atccatgcta tttccatcct gacttctgtg actgtcatca gcctttcgta tttaagaatc 660

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069269_0225_SL.TXT atcacagtga tcctgaggat tccctcaggg gcgagccgtc agaaggcgtt ctccacttgt gcggcccaca ttactatttt cttgctgttt tttggcagcg tggccctcac gtacctgcgc ttctctgtca cgttcccacc tctactggac aaggccattg cactgatgtt tgctgtcctt gccccgcttt tcaacccaat aatttatagc ctgaggaaca aagacatgaa agatgccatc aggaaagttc tctgtttccg atcaatgttc aatgtctctg gtagccaatg a

720

780

840

900

951 <210> 1826 <211> 316 <212> PRT <213> Canis familiaris

<400> 1826 Asp Met 1 Asp Pro Glu Asn Gln 5 Thr Gly Val Ala 10 Glu Phe Tyr Phe Ser 15 Phe Pro Pro Phe Gly Asn Gly Ser Leu Leu Leu Phe Thr Pro Leu Leu 20 25 30 Phe Ile Tyr Ala Phe Ile Ile Val Gly Asn Phe Thr Ile Phe Ser Ala 35 40 45 Val Arg Leu Asp Thr Arg Leu His Asn Pro Met Tyr Asn Leu Ile Ser 50 55 60 Ala Phe Ser Phe Leu Glu Val Trp Tyr Thr Thr Ala Thr Ile Pro Lys 65 70 75 80 Met Leu Ser Asn Leu Val Ser Glu Lys Lys Ala Ile Ser Phe Thr Gly 85 90 95 Cys Leu Leu Gln Met Tyr Phe Phe His Ser Leu Gly Val Thr Glu Ala 100 105 110 Leu Val Leu Thr Val Met Ala Ile Asp Arg Tyr Ile Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Ala Ile Ile Met Thr Pro Arg Leu Cys Val Gln Leu

130 135 140

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Ser 145 Thr Gly Ser Cys Ile Phe 150 Gly Phe Leu Met 155 Leu Leu Pro Glu Ile 160 Val Trp Ile Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His Gln 165 170 175 Leu Phe Cys Asp Phe Glu Pro Met Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 Ser Met Ile Leu Val Glu Asp Val Ile His Ala Ile Ser Ile Leu Thr 195 200 205 Ser Val Thr Val Ile Ser Leu Ser Tyr Leu Arg Ile Ile Thr Val Ile 210 215 220 Leu Arg Ile Pro Ser Gly Ala Ser Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ala His Ile Thr Ile Phe Leu Leu Phe Phe Gly Ser Val Ala Leu 245 250 255 Thr Tyr Leu Arg Phe Ser Val Thr Phe Pro Pro Leu Leu Asp Lys Ala 260 265 270 Ile Ala Leu Met Phe Ala Val Leu Ala Pro Leu Phe Asn Pro Ile Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Ile Arg Lys Val Leu 290 295 300 Cys Phe Arg Ser Met Phe Asn Val Ser Gly Ser Gln

305 310 315 <210> 1827 <211> 957 <212> DNA <213> Canis familiaris <400> 1827

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069269_0225_SL.TXT atggtaggag ctaaccaaac ttctatggtg acagaatttc tcttctctgg cttccccaag 60 tttgaagatg gtagcctcct cctcttcatt cctttgttca tcatctacac atttatcatt 120 gttgggaatc tcactgtatt ttttgcggtc aggatggatg cccacctcca caatcctatg 180 tacaatttca taagcacctt ctccttcttg gaggtctggt acaccacagc caccatcccc 240 aagatgctct ccaacctcat cagtgagaag aggaccatct ccatgactgg ctgcctcctg 300 cagatgtact tcttccattc tcttggaaat tcagagggga ttttgttaac caccatggcc 360 attgacaggt acgttgctat ctgcaaccct ctccgctacc caaccattat gaccccccgg 420 ctgtgtgctc agctctctgc gggctcttgc atctttggct ttcttgtgtt actcccagag 480 attgcatgga tttccacact gcctttctgt gggcccaacc aaatccatca gatattctgt 540 gactttgaac ctgtgctacg cttggcctgt acagacacgt ccatgattct gattgaggat 600 gtgatccatg ctgtggccat catcatcgct gtactgatca ttgctctctc ttatatcgga 660 atcatcactg tgatcctgag gatcccttct gttgaaggcc gccagaaggc cttttctacc 720 tgtgcatctc atcttggtgt ctttctgatg ttctatggca gtgtctccct catgtacctg 780 cgtttctctg ccactttccc accaactttg gacacagtca ttgcattgat gtttgccgtt 840 cttgctccct ttttcaaccc tatcatttat agcttgagaa acaaggatat gaagattgct 900 attaagaagc ttctcttttc tggatcacct gggtggctta gttggttaag tgtctga 957 <210> 1828 <211> 318 <212> PRT <213> Canis familiaris

<400> 1828 Met 1 Val Gly Ala Asn Gln Thr Ser Met Val Thr Glu Phe Leu Phe Ser 5 10 15 Gly Phe Pro Lys Phe Glu Asp Gly Ser Leu Leu Leu Phe Ile Pro Leu 20 25 30 Phe Ile Ile Tyr Thr Phe Ile Ile Val Gly Asn Leu Thr Val Phe Phe 35 40 45 Ala Val Arg Met Asp Ala His Leu His Asn Pro Met Tyr Asn Phe Ile Page 2049

069269_0225_SL.TXT

50 55 60 Ser Thr Phe Ser Phe Leu Glu Val Trp Tyr Thr Thr Ala Thr Ile Pro 65 70 75 80 Lys Met Leu Ser Asn Leu Ile Ser Glu Lys Arg Thr Ile Ser Met Thr 85 90 95 Gly Cys Leu Leu Gln Met Tyr Phe Phe His Ser Leu Gly Asn Ser Glu 100 105 110 Gly Ile Leu Leu Thr Thr Met Ala Ile Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Pro Thr Ile Met Thr Pro Arg Leu Cys Ala Gln 130 135 140 Leu Ser Ala Gly Ser Cys Ile Phe Gly Phe Leu Val Leu Leu Pro Glu 145 150 155 160 Ile Ala Trp Ile Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His 165 170 175 Gln Ile Phe Cys Asp Phe Glu Pro Val Leu Arg Leu Ala Cys Thr Asp 180 185 190 Thr Ser Met Ile Leu Ile Glu Asp Val Ile His Ala Val Ala Ile Ile 195 200 205 Ile Ala Val Leu Ile Ile Ala Leu Ser Tyr Ile Gly Ile Ile Thr Val 210 215 220 Ile Leu Arg Ile Pro Ser Val Glu Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Gly Val Phe Leu Met Phe Tyr Gly Ser Val Ser 245 250 255 Leu Met Tyr Leu Arg Phe Ser Ala Thr Phe Pro Pro Thr Leu Asp Thr

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069269_0225_SL.TXT 265 270

Val Ile Ala 275 Leu Met Phe Ala Val Leu Ala Pro Phe Phe Asn Pro Ile 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Ile Ala Ile Lys Lys Leu 290 295 300 Leu Phe Ser Gly Ser Pro Gly Trp Leu Ser Trp Leu Ser Val 305 310 315

<210> 1829 <211> 948 <212> DNA <213> Canis familiaris <400> 1829

atggagggtg caaatctgtc agcagtgatg gaatttgtct tcactggctt cccccagctc 60 caggatggtg gcctcctgta cttcttcccc ttactcttca tctacgcctt tgttgtcgtt 120 gggaatctat tgatcttctt tgcggtcagg atggatgccc gcctccacaa ccccatgtac 180 aacttcatca gcaccttctc cttcctggag gtctggtaca ccacagccac catccccaag 240 atgctctcca acctgatcag tgagaagaag accatctcca tgaccggctg cctcctgcag 300 atgtacttct tccattccct tgggaacact gaaggagccc tgctgactgt catggccatt 360 gacaggtacg tggccatctg caacccactc cgctacctga ccatcatgac ccctcggctg 420 tgtgctcagc tctctgcagg ctcttgtatc tttggtctcc tcatccttct acctgagatt 480 gtgtggattt ctactctgcc cttctgtggc cccaaccaaa tccatcagat cttctgtgac 540 ttcacaccgt tattacgttt agcctgtact gatgcctctg tgatcctggt gcaagatgtg 600 attcatgctc tggccattct gataacaggt ctgatcattt ccctttccta catcagaatt 660 gtcaccgtga tcctgggcat cccttctgca gagggccgta aaaaggcctt ctccacctgt 720 gccgcccaca ttgctgtctt cctgctattt ttcggcagcg tggccctcat gtatcttaga 780 ttctctgcca cgtatacacc attctgggat gctgccattg ctctgacctt ctctgtcctc 840 tccccctttt tcaatcccat tatatacagc ctgagaaata aggatatgaa agatgctatt 900 aagaaactcc tttgccctca aaaggtgttt aatgtacctg gtaggtga 948

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069269_0225_SL.TXT <210> 1830 <211> 315 <212> PRT <213> Canis familiaris

<400> 1830 Met 1 Glu Gly Ala Asn 5 Leu Ser Ala Val Met 10 Glu Phe Val Phe Thr 15 Gly Phe Pro Gln Leu Gln Asp Gly Gly Leu Leu Tyr Phe Phe Pro Leu Leu 20 25 30 Phe Ile Tyr Ala Phe Val Val Val Gly Asn Leu Leu Ile Phe Phe Ala 35 40 45 Val Arg Met Asp Ala Arg Leu His Asn Pro Met Tyr Asn Phe Ile Ser 50 55 60 Thr Phe Ser Phe Leu Glu Val Trp Tyr Thr Thr Ala Thr Ile Pro Lys 65 70 75 80 Met Leu Ser Asn Leu Ile Ser Glu Lys Lys Thr Ile Ser Met Thr Gly 85 90 95 Cys Leu Leu Gln Met Tyr Phe Phe His Ser Leu Gly Asn Thr Glu Gly 100 105 110 Ala Leu Leu Thr Val Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Leu Thr Ile Met Thr Pro Arg Leu Cys Ala Gln Leu 130 135 140 Ser Ala Gly Ser Cys Ile Phe Gly Leu Leu Ile Leu Leu Pro Glu Ile 145 150 155 160 Val Trp Ile Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His Gln 165 170 175

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Ile Phe Cys Asp Phe Thr Pro Leu Leu Arg Leu Ala Cys Thr Asp Ala 180 185 190 Ser Val Ile Leu Val Gln Asp Val Ile His Ala Leu Ala Ile Leu Ile 195 200 205 Thr Gly Leu Ile Ile Ser Leu Ser Tyr Ile Arg Ile Val Thr Val Ile 210 215 220 Leu Gly Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ala His Ile Ala Val Phe Leu Leu Phe Phe Gly Ser Val Ala Leu 245 250 255 Met Tyr Leu Arg Phe Ser Ala Thr Tyr Thr Pro Phe Trp Asp Ala Ala 260 265 270 Ile Ala Leu Thr Phe Ser Val Leu Ser Pro Phe Phe Asn Pro Ile Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Ile Lys Lys Leu Leu 290 295 300 Cys Pro Gln Lys Val Phe Asn Val Pro Gly Arg

305 310 315 <210> 1831 <211> 966 <212> DNA <213> Canis familiaris <400> 1831 atggagagcc ccaatcaaag caccactcag gagttcatct tctccgcctt cccttgttcc tggggaagct ccgtctcctg ttttgttccc ctgctcttca tttacacttt cattgtcttc ggcaacctgg tcatcatcac agtggtccag ctgaacgctc acctccacac gcccatgtac ttcttcatca gcgccctttc tttcctggaa atctggtaca ccacagcgac catcccaaag atgcttgcca gcctgctgag tgagaggaag agcatttcct taaatggttg tctcctgcag

120

180

240

300

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069269_0225_SL.TXT

atgtacttct tccattccac tggcatcagt gaggtttgtc tgttgacagc aatggccttt 360 gaccactacc tggccatctg cagccctctt cattatccca ctaccatgac ccccaggctg 420 tgtgcccaac tgactttaag ttgctgtgtt tgtggcttta tcacgcctct ccctgagatt 480 gcctggatct ccacactgcc attttgtggc tctaatcatc ttgagcacat cttctgtgac 540 ttcctcccca tgctacgctt ggcctgcaca gacacacaag ccatcgtcat gattcaggta 600 gtggatattg tccatgcggt ggagattatt acagctataa tgctcatttt catgtcctat 660 gttggtattg tggctgtaat tctacatatt aggtcagctg aaggccgacg caaggcgttt 720 tccacgtgcg tctcccacct cactgttttt ttgctttttt ttggcaatgt ggccctcatg 780 tacctacgct tctctgccac ctactcctta ttctgggata cagtcattgc tctggccttt 840 gcagttttgt ctcccttctt caaccccatc atttatagcc tgaggaacaa agagataaag 900 gaagcgataa aaaaacactg gggtcaagct aaaatctttt tttataagac caaggacctc 960 aagtaa 966 <210> 1832 <211> 321 <212> PRT <213> Canis familiaris <400> 1832 Met Glu Ser Pro Asn Gln Ser Thr Thr Gln Glu Phe Ile Phe Ser Ala 1 5 10 15 Phe Pro Cys Ser Trp Gly Ser Ser Val Ser Cys Phe Val Pro Leu Leu 20 25 30 Phe Ile Tyr Thr Phe Ile Val Phe Gly Asn Leu Val Ile Ile Thr Val 35 40 45 Val Gln Leu Asn Ala His Leu His Thr Pro Met Tyr Phe Phe Ile Ser 50 55 60 Ala Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys 65 70 75 80 Met Leu Ala Ser Leu Leu Ser Glu Arg Lys Ser Ile Ser Leu Asn Gly

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069269_0225_SL.TXT

85 90 95

Cys Leu Leu Gln Met 100 Tyr Phe Phe His Ser Thr Gly Ile Ser Glu Val 105 110 Cys Leu Leu Thr Ala Met Ala Phe Asp His Tyr Leu Ala Ile Cys Ser 115 120 125 Pro Leu His Tyr Pro Thr Thr Met Thr Pro Arg Leu Cys Ala Gln Leu 130 135 140 Thr Leu Ser Cys Cys Val Cys Gly Phe Ile Thr Pro Leu Pro Glu Ile 145 150 155 160 Ala Trp Ile Ser Thr Leu Pro Phe Cys Gly Ser Asn His Leu Glu His 165 170 175 Ile Phe Cys Asp Phe Leu Pro Met Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 Gln Ala Ile Val Met Ile Gln Val Val Asp Ile Val His Ala Val Glu 195 200 205 Ile Ile Thr Ala Ile Met Leu Ile Phe Met Ser Tyr Val Gly Ile Val 210 215 220 Ala Val Ile Leu His Ile Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe 225 230 235 240 Ser Thr Cys Val Ser His Leu Thr Val Phe Leu Leu Phe Phe Gly Asn 245 250 255 Val Ala Leu Met Tyr Leu Arg Phe Ser Ala Thr Tyr Ser Leu Phe Trp 260 265 270 Asp Thr Val Ile Ala Leu Ala Phe Ala Val Leu Ser Pro Phe Phe Asn 275 280 285 Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Glu Ala Ile Lys

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290 295 300

Lys His Trp Gly Gln Ala Lys Ile Phe Phe Tyr Lys Thr Lys Asp Leu 305 310 315 320

Lys <210> 1833 <211> 942 <212> DNA <213> Canis familiaris <400> 1833

atgggacagg ccaatgcaac catctggagg ggattcgtct tcctgggctt ctccagcttt 60 ggggagctgc agctcctgct ctttgcacta ttcctctccc tgtatcttgt caccctgacc 120 agcaatgtct tcattatcgt agtcatccgg ctggacagcc atctgcacag ccccatgtac 180 ttcttccttt cctttctgtc tttctctgag acctgttata cactgggcat catccctcgg 240 atgctctcca gcctggtcat ggggagccag gccatctcct atgagggctg tgctgcccag 300 atgttcttct ccgcttcgtg ggcctgtacc aactgcttcc ttctggctgt catgggcttt 360 gacagatacg tggccatctg tgccccactg cactatacca gccacatgaa tcctaccttc 420 tgtgcccagc tggttggcac ctccttcttg actggatatc tctttgggct gggaatgaca 480 ctggtcattt tccaactccc attctgtggt tcccacgaga tccagcactt tttctgtgac 540 acgcctccag tgctgagcct ggcctgcggg gacacggggc caagtgagct gggcatcctc 600 atccttagcc tgctggtcct cctggtctct ttctgctcca ttaccatctc ctatgcctac 660 attctgacag caatactgcg gatcccctct gccaaggggc ggaagaaggc cttctccacc 720 tgcgcctcgc acctcaccgt ggtcattgtg cactatggct gtgcctcctt catgtacttg 780 aggcccaaag ccagttactc tctggagcga gatcagctta ttgctgtcac ctacaccgtg 840 gtgactcccc tcctcaaccc cattgtttac agtctaagga atcgggctgt gcagacagcc 900 ctgagaagtg ccttccgagg aaaattgctg ggtagaggat ga 942

<210> 1834 <211> 313

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069269_0225_SL.TXT familiaris <212> PRT <213> Canis <400> 1834 Met Gly Gln 1

Phe Ser Ser

Ser Leu Tyr 35

Ile Arg Leu 50

Phe Leu Ser 65

Met Leu Ser

Cys Ala Ala

Phe Leu Leu 115

Pro Leu His 130

Val Gly Thr 145

Leu Val Ile

Phe Phe Cys

Ala Asn Ala 5 Thr Ile Trp Arg Gly Phe Val Phe Leu Gly 10 15 Phe Gly Glu Leu Gln Leu Leu Leu Phe Ala Leu Phe Leu 20 25 30 Leu Val Thr Leu Thr Ser Asn Val Phe Ile Ile Val Val 40 45 Asp Ser His Leu His Ser Pro Met Tyr Phe Phe Leu Ser 55 60 Phe Ser Glu Thr Cys Tyr Thr Leu Gly Ile Ile Pro Arg 70 75 80 Ser Leu Val Met Gly Ser Gln Ala Ile Ser Tyr Glu Gly 85 90 95 Gln Met Phe Phe Ser Ala Ser Trp Ala Cys Thr Asn Cys 100 105 110 Ala Val Met Gly Phe Asp Arg Tyr Val Ala Ile Cys Ala 120 125 Tyr Thr Ser His Met Asn Pro Thr Phe Cys Ala Gln Leu 135 140 Ser Phe Leu Thr Gly Tyr Leu Phe Gly Leu Gly Met Thr 150 155 160 Phe Gln Leu Pro Phe Cys Gly Ser His Glu Ile Gln His 165 170 175 Asp Thr Pro Pro Val Leu Ser Leu Ala Cys Gly Asp Thr 180 185 190

Page 2057

Gly Pro Ser 195 Glu Leu Gly Ile 069269_0225_SL.TXT Leu Ile Leu Ser Leu Leu 200 205 Val Leu Leu Val Ser Phe Cys Ser Ile Thr Ile Ser Tyr Ala Tyr Ile Leu Thr Ala 210 215 220 Ile Leu Arg Ile Pro Ser Ala Lys Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ile Val His Tyr Gly Cys Ala Ser 245 250 255 Phe Met Tyr Leu Arg Pro Lys Ala Ser Tyr Ser Leu Glu Arg Asp Gln 260 265 270 Leu Ile Ala Val Thr Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Ile 275 280 285 Val Tyr Ser Leu Arg Asn Arg Ala Val Gln Thr Ala Leu Arg Ser Ala 290 295 300 Phe Arg Gly Lys Leu Leu Gly Arg Gly

305 310 <210> 1835 <211> 960 <212> DNA <213> Canis familiaris <400> 1835

atgcagagaa agaacttcac ggaagtgaca gatctcatct tcctgggatt ttctatcttt 60 ggaaagcacc agctaacgct ctttgtggtt ttcctgactg tctacatttt aactctaact 120 agtaatgtca tcattgtgac catcatccgt gttgaccgcc acctgcacac gcccatgtac 180 ttcctcctga gcatgctggc cagttctgag actgtgtaca cactggtcat tgtcccacga 240 atgctttcca gtctcctttt tcataaccag cccatctcct tggcaggctg tgcaactcag 300 atgttcttct ttgtcacctt ggccaccagt aactgcttct tgcttacagc gatgggctat 360 gaccgctacc tggcgatctg cagccccctg tggtacacgg tcctcatgag caaaggagtg 420

Page 2058

069269_0225_SL.TXT

tgtgccacct tggtatgcgg gtccttcggt accggcctgg ctatggcagt tctccatgtg 480 gcagcaatgt tcaacttgcc cttctgtggc acagtggtgg agcacttctt ctgtgacatt 540 tacccagtca tgaaactttc ctgtgttgat accactatca atgagatgat caattatgct 600 gtcagttcat ttgtgatcct ggtccctgtg ggcttgatct tcatctccta tgtcttcatc 660 atctctgcca ttctcaagat tgcctccgca gaaggccgga agaaggcctt tgccacctgc 720 acctcccacc tcaccgtggt catcgtccac tacggctgcg cctccatcgc ctacctcaag 780 cccaagtcgg agaactccat agaacaagac ctccttctct cggtgactta taccatcatc 840 acgcctctgc tcaaccctgt tgtctacagc ctgaggaaca aggaggtcaa agatgccctc 900 cgcagagctg tgggcaaaaa catcataaca gatcgaatcg ctttgtcagg agacgtttag 960

<210> 1836 <211> 319 <212> PRT <213> Canis familiaris <400> 1836

Met Gln Arg Lys Asn Phe Thr Glu Val Thr Asp Leu Ile Phe Leu Gly 1 5 10 15 Phe Ser Ile Phe Gly Lys His Gln Leu Thr Leu Phe Val Val Phe Leu 20 25 30 Thr Val Tyr Ile Leu Thr Leu Thr Ser Asn Val Ile Ile Val Thr Ile 35 40 45 Ile Arg Val Asp Arg His Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Met Leu Ala Ser Ser Glu Thr Val Tyr Thr Leu Val Ile Val Pro Arg 65 70 75 80 Met Leu Ser Ser Leu Leu Phe His Asn Gln Pro Ile Ser Leu Ala Gly 85 90 95 Cys Ala Thr Gln Met Phe Phe Phe Val Thr Leu Ala Thr Ser Asn Cys 100 105 110

Page 2059

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Phe Leu Leu 115 Thr Ala Met Gly Tyr Asp Arg Tyr Leu Ala Ile Cys Ser 120 125 Pro Leu Trp Tyr Thr Val Leu Met Ser Lys Gly Val Cys Ala Thr Leu 130 135 140 Val Cys Gly Ser Phe Gly Thr Gly Leu Ala Met Ala Val Leu His Val 145 150 155 160 Ala Ala Met Phe Asn Leu Pro Phe Cys Gly Thr Val Val Glu His Phe 165 170 175 Phe Cys Asp Ile Tyr Pro Val Met Lys Leu Ser Cys Val Asp Thr Thr 180 185 190 Ile Asn Glu Met Ile Asn Tyr Ala Val Ser Ser Phe Val Ile Leu Val 195 200 205 Pro Val Gly Leu Ile Phe Ile Ser Tyr Val Phe Ile Ile Ser Ala Ile 210 215 220 Leu Lys Ile Ala Ser Ala Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys 225 230 235 240 Thr Ser His Leu Thr Val Val Ile Val His Tyr Gly Cys Ala Ser Ile 245 250 255 Ala Tyr Leu Lys Pro Lys Ser Glu Asn Ser Ile Glu Gln Asp Leu Leu 260 265 270 Leu Ser Val Thr Tyr Thr Ile Ile Thr Pro Leu Leu Asn Pro Val Val 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Arg Arg Ala Val 290 295 300 Gly Lys Asn Ile Ile Thr Asp Arg Ile Ala Leu Ser Gly Asp Val 305 310 315

Page 2060

069269_0225_SL.TXT <210> 1837 <211> 942 <212> DNA <213> Canis familiaris <400> 1837 atgcaaacaa tgaaggtcaa ccagacagtc ctgaaggaat tcattcttgt tggcttttcc 60 gtgtaccccc atgtgcaggc tttcctcttc gtggtcttcc tttgcctcta tcttctcacc 120 ctcacaggta acctggctat catgggtcta acttgggtgg acagatctct ccacacccct 180 atgtacctct tccttggtgc cctctctttc tccgagacct gctacacact gaccatcatc 240 cccaagatgc tggccgatct gctgactgaa aacaagagca tctcagtcat ggggtgtggc 300 ttgcagatgt gtttcttctt gggactcggt ggcacaaatt gtatcatcct caccttgatg 360 ggatatgatc gctttctggc catctgcaac cctctcagat atccactgct tatgaccaat 420 ggggtgtgtg gacagcttgt ggcctctgct tgggggggag gctttctcat ctctctgata 480 gagactgcac tgatattcag gggctccttc tgcagcccca acctcgtcaa acacttcttc 540 tgccacatgc ggacagtggc gaggctggcc tgtatagaca gcaacctcac tgaatccatt 600 gtgacgatga tctcagtgtc aggcttgatg ggcaccttcc tgctcatcat catcacttac 660 gtgttcattc tctccactgt attcaggatc ccatcagcca agggcaagca gaaggccttc 720 tctacctgcg cctcgcatct cacagtggtc attatccact ttgggtttgc cgctattgtc 780 tatatgaagc cagaaacttc ggggggagat gataccctca tgtctgtccc ttatacagtc 840 attactcctt tcctcagccc cctcattttc agcctcagga ataaggacat gaagaatgcc 900 tttaggaagg tgcttggaaa gagaagtttc ttaaataaat aa 942 <210> 1838 <211> 313 <212> PRT <213> Canis familiaris <400> 1838

Met Gln Thr Met Lys Val Asn Gln Thr Val Leu Lys Glu Phe Ile Leu 1 5 10 15 Val Gly Phe Ser Val Tyr Pro His Val Gln Ala Phe Leu Phe Val Val

20 25 30

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Phe Leu Cys Leu Tyr Leu Leu Thr Leu Thr Gly Asn Leu Ala Ile Met 35 40 45 Gly Leu Thr Trp Val Asp Arg Ser Leu His Thr Pro Met Tyr Leu Phe 50 55 60 Leu Gly Ala Leu Ser Phe Ser Glu Thr Cys Tyr Thr Leu Thr Ile Ile 65 70 75 80 Pro Lys Met Leu Ala Asp Leu Leu Thr Glu Asn Lys Ser Ile Ser Val 85 90 95 Met Gly Cys Gly Leu Gln Met Cys Phe Phe Leu Gly Leu Gly Gly Thr 100 105 110 Asn Cys Ile Ile Leu Thr Leu Met Gly Tyr Asp Arg Phe Leu Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Pro Leu Leu Met Thr Asn Gly Val Cys Gly 130 135 140 Gln Leu Val Ala Ser Ala Trp Gly Gly Gly Phe Leu Ile Ser Leu Ile 145 150 155 160 Glu Thr Ala Leu Ile Phe Arg Gly Ser Phe Cys Ser Pro Asn Leu Val 165 170 175 Lys His Phe Phe Cys His Met Arg Thr Val Ala Arg Leu Ala Cys Ile 180 185 190 Asp Ser Asn Leu Thr Glu Ser Ile Val Thr Met Ile Ser Val Ser Gly 195 200 205 Leu Met Gly Thr Phe Leu Leu Ile Ile Ile Thr Tyr Val Phe Ile Leu 210 215 220 Ser Thr Val Phe Arg Ile Pro Ser Ala Lys Gly Lys Gln Lys Ala Phe 225 230 235 240

Page 2062

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Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Ile His Phe Gly Phe 245 250 255

Ala Ala Ile Val Tyr Met Lys Pro Glu Thr Ser Gly Gly Asp Asp Thr 260 265 270

Leu Met Ser Val Pro Tyr Thr Val Ile Thr Pro Phe Leu Ser Pro Leu 275 280 285

Ile Phe Ser Leu Arg Asn Lys Asp Met Lys Asn Ala Phe Arg Lys Val 290 295 300

Leu Gly Lys Arg Ser Phe Leu Asn Lys 305 310 <210> 1839 <211> 957 <212> DNA <213> Canis familiaris <400> 1839 atgatgggaa atttgagtgg aggccacata tctccacccc tccagttact tctctttgtc ttggagaatg cactcatcgt ttccacaatc tactttttcc ttggccatct gtccttcctg cgtcttttgg gagcatttct tacccaggac cagctctact tcttcattgc cctagcctgc tatgaccgct acctggccat ctgtgagccc ctggccattc gccttgctgc ttcctcttgg cttcttttca tttcccgact gtcctactgt gatatctccc cactactcaa ccttacctgc ttcctgttgg ccctggtgat gatcctgctt gccatcattg ccaccatcct gaggatccct gcagatttta ctcttctttg tggctcactc gagctgtggt cgtagagtct accgaatgtg ctccgttatc ggtggtggct gggcccaaca tctgacaagg cctctactgg actgcccagg

ttttggtggg cttcccaacc 60 caatttacct gttgacactg 120 caagccttca ccgcccgatg 180 acatcaatgt cacagttcct 240 cctatgtagg ctgcatgacc 300 tcctgctggc agtcatggcc 360 ctagtctcat gccgtccagc 420 tcttcagctc catgatgaag 480 tcatcaacca ttttttctgt 540 agcaagcaga actagtagac 600 ctgtggtttc atcatatgct 660 gacgtcgcaa agccttttcc 720

Page 2063

069269_0225_SL.TXT acctgtgcct gcaaggcccc gtcattgtac gctctcagga ctcacctggc gggccatgta cattcctcaa agttggttct agtggttgtc caccttcaac tccagccatc gggcagatgc atctactact cacaacaaga tactgcctga cactatccta cctccaccct tcatctctgt ggaacaagga gtgatgtccc cttcacctat gctctatacg ggtgaaggat agactga

780

840

900

957 <210> 1840 <211> 318 <212> PRT <213> Canis <400> 1840 Met Met Gly 1 familiaris

Gly Phe Pro

Phe Ala Ile 35

Thr Ile Trp 50

Gly His Leu 65

Arg Leu Leu

Gly Cys Met

Cys Val Leu 115

Glu Pro Leu 130

Leu Ala Ala

Asn Leu Ser 5 Gly Gly His Ile Ala Asp Phe Ile Leu Val 10 15 Thr Ser Pro Pro Leu Gln Leu Leu Leu Phe Val Leu Phe 20 25 30 Tyr Leu Leu Thr Leu Leu Glu Asn Ala Leu Ile Val Ser 40 45 Leu Thr Pro Ser Leu His Arg Pro Met Tyr Phe Phe Leu 55 60 Ser Phe Leu Glu Leu Trp Tyr Ile Asn Val Thr Val Pro 70 75 80 Gly Ala Phe Leu Thr Gln Asp Arg Arg Val Ser Tyr Val 85 90 95 Thr Gln Leu Tyr Phe Phe Ile Ala Leu Ala Cys Thr Glu 100 105 110 Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys 120 125 Arg Tyr Pro Ser Leu Met Pro Ser Ser Leu Ala Ile Arg 135 140 Ser Ser Trp Gly Gly Gly Phe Phe Ser Ser Met Met Lys

Page 2064

0 6926 9_02 25_S L.TX T 145 150 155 160 Leu Leu Phe Ile Ser Arg Leu Ser Tyr Cys Gly Pro Asn Ile Ile Asn 165 170 175 His Phe Phe Cys Asp Ile Ser Pro Leu Leu Asn Leu Thr Cys Ser Asp 180 185 190 Lys Glu Gln Ala Glu Leu Val Asp Phe Leu Leu Ala Leu Val Met Ile 195 200 205 Leu Leu Pro Leu Leu Ala Val Val Ser Ser Tyr Ala Ala Ile Ile Ala 210 215 220 Thr Ile Leu Arg Ile Pro Thr Ala Gln Gly Arg Arg Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Ala Val Val Val Ile Tyr Tyr Ser Ser Thr 245 250 255 Leu Phe Thr Tyr Ala Arg Pro Arg Ala Met Tyr Thr Phe Asn His Asn 260 265 270 Lys Ile Ile Ser Val Leu Tyr Thr Val Ile Val Pro Phe Leu Asn Pro 275 280 285 Ala Ile Tyr Cys Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Arg Lys 290 295 300 Leu Val Leu Gly Arg Cys His Tyr Pro Ser Asp Val Pro Asp 305 310 315

<210> 1841 <211> 909 <212> DNA <213> Canis familiaris <400> 1841 ttcattctcc tgggatttcc aacacggcca gccttccagc tgttcctctt ttttgtgttc ctggcagctt acctgctgac cctgctggag aacgctctca tcatcctggc cattcgcagt

120

Page 2065

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gatggacagt tgcacaaacc catgtacttc ttcctgagca acctctcctt cctggagatg 180 tggtatgtca cggtcatcag ccccaagatg ctggtcgact tcctcagcca tgacaagacc 240 atctccttca atggctgcat gactcaactg tacttctttg tgacctttgt ctgcacggag 300 tacatcctcc ttgctgttat ggcctttgac cgccatgtag ccatttgtaa tcctctacgc 360 tatccagtca tcatgaccaa ccagctgtgt ggtacattgg ctgcgggatg ctggctctgt 420 gggctcgtga ctgccatgat taagatggtt ttcatagccc gactccacta ctgtggcacc 480 ccccacatca atcactactt ttgtgatatt tctccgctcc tcaatgtctc ttgtgaggac 540 tcctcacagg ctgagctagt ggacttcttc ttggccctca tggtcattgc cgtccccctt 600 tgtgtagtgg tggcatctta cgccaccatt ctcagcacca tcatcaggat cccttctaca 660 cagggccgcc aaaaggcgtt ttccacctgt gcctctcacc tgacggttgt aatcctcttc 720 tactctacaa cccttttcac ctatgcccgc cccaagctca tgtacgccta taactccaac 780 aaagcggtgt ctgtgctcta cactgtcatc gtccccctgc tcaaccccat catctactgt 840 ctgaggaacc gtgaagtaaa ggcagccctc aagaagacca tactttgcaa aggaagtggg 900

cccggggaa 909 <210> 1842 <211> 303 <212> PRT <213> Canis familiaris <400> 1842

Phe Ile Leu Leu Gly Phe Pro Thr Arg Pro Ala Phe Gln Leu Phe Leu 1 5 10 15 Phe Phe Val Phe Leu Ala Ala Tyr Leu Leu Thr Leu Leu Glu Asn Ala 20 25 30 Leu Ile Ile Leu Ala Ile Arg Ser Asp Gly Gln Leu His Lys Pro Met 35 40 45 Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Glu Met Trp Tyr Val Thr 50 55 60

Page 2066

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Val 65 Ile Ser Pro Lys Met 70 Leu Val Asp Phe Leu Ser His Asp Lys Thr 75 80 Ile Ser Phe Asn Gly Cys Met Thr Gln Leu Tyr Phe Phe Val Thr Phe 85 90 95 Val Cys Thr Glu Tyr Ile Leu Leu Ala Val Met Ala Phe Asp Arg His 100 105 110 Val Ala Ile Cys Asn Pro Leu Arg Tyr Pro Val Ile Met Thr Asn Gln 115 120 125 Leu Cys Gly Thr Leu Ala Ala Gly Cys Trp Leu Cys Gly Leu Val Thr 130 135 140 Ala Met Ile Lys Met Val Phe Ile Ala Arg Leu His Tyr Cys Gly Thr 145 150 155 160 Pro His Ile Asn His Tyr Phe Cys Asp Ile Ser Pro Leu Leu Asn Val 165 170 175 Ser Cys Glu Asp Ser Ser Gln Ala Glu Leu Val Asp Phe Phe Leu Ala 180 185 190 Leu Met Val Ile Ala Val Pro Leu Cys Val Val Val Ala Ser Tyr Ala 195 200 205 Thr Ile Leu Ser Thr Ile Ile Arg Ile Pro Ser Thr Gln Gly Arg Gln 210 215 220 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Leu Phe 225 230 235 240 Tyr Ser Thr Thr Leu Phe Thr Tyr Ala Arg Pro Lys Leu Met Tyr Ala 245 250 255 Tyr Asn Ser Asn Lys Ala Val Ser Val Leu Tyr Thr Val Ile Val Pro 260 265 270

Page 2067

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Leu Leu Asn Pro Ile Ile Tyr Cys Leu Arg Asn Arg Glu Val Lys Ala 275 280 285 Ala Leu Lys Lys Thr Ile Leu Cys Lys Gly Ser Gly Pro Gly Glu

290 295 300 <210> 1843 <211> 972 <212> DNA <213> Canis familiaris <400> 1843

ctaatttctc cctcctctgt cacagtgttc ctattgcttg ggttctccaa cctttgagaa 60 atccagctcg tcccctttgc tgtgtttctc tgcctgtatc tgattattct gaaggggaac 120 atcgccgttg tcgttgtcat acgcctggat ggcagtctcc aaggacctat gtacttcttc 180 ctggggatcc tctccatctc tgagacatgc tacgtctttg tcatcctgcc caagatgctc 240 ataaatctgt tgtctctgct cagaacaatc tcatttatta actgtgctac tcagatcttg 300 ttcttcctcg gttttgctgt cactgattac atgctgctca gggtcatggg ttatgaccgc 360 tttgctgcca cttgtcatcc acttcagtac cctaccctaa tgagctggca ggtatgtaga 420 caactggtag ccacctgtgc tgtgattgtt tttttatcct cattgacagg ctcccgtttt 480 agtctttgaa ctcccttttt agtctttgaa ctcccttttt gtggccccaa tataatcaac 540 cactacttct gtgacatctc ctggcttgcc tgtattgaaa cctatgtcaa cgagccggtc 600 gtcctcattg gtggagttct agccctcctg gtccccctga cttacatctg catctcttac 660 tgctgcattg tccataccat cctaaagatc ttgtccatac catcctaaag atctcaccct 720 gatggcaagc agaaagcctt ctccacctgt gtctcccacc ccactgtggt catcgtccac 780 aatggctgtg cctcctctgt ctacctgcgg ccctcagccg agttctcatc taacaaagtc 840 aggcttgtga caacgaccta tacagttgtg actccattgt tgagcccaat ggtttatagc 900 ctcaggaaca aagatgtcca gatggccatt cagaaagtga ttggcagagg aggattttat 960 cctaaagctc tg 972

<210> 1844 <211> 66 <212> PRT

Page 2068

069269_0225_SL.TXT <213> Canis familiaris <400> 1844

Asn Phe Ser Leu Leu Cys His Ser Val Pro Ile Ala Trp Val Leu Gln 1 5 10 15 Pro Leu Arg Asn Pro Ala Arg Pro Leu Cys Cys Val Ser Leu Pro Val 20 25 30 Ser Asp Tyr Ser Glu Gly Glu His Arg Arg Cys Arg Cys His Thr Pro 35 40 45 Gly Trp Gln Ser Pro Arg Thr Tyr Val Leu Leu Pro Gly Asp Pro Leu 50 55 60

His Leu 65 <210> 1845 <211> 942 <212> DNA <213> Canis familiaris <400> 1845

atggccaatt cttcccgggt cactgagttc ctgctgctcg gtttctccag ctttggcgaa 60 ttgcagcctg tgctctttgt gctctttctc agcctctact tgatcatcct gagtggaaac 120 ttcaccatca tctccgtcat ccgcctggac cgcagcctcc acacgcccat gtacttcttt 180 ctctgtgtcc tgtccacctc ggaagtcttc tacacaattg ttatcctgcc caagatgctt 240 attaacctgc tctctgtcct caggacactc tccttcacca gctgtgccac acagatgttc 300 ttcttccttg gcttcgggat cacgaactgc ctgcttctgg gagttatggg ttatgaccgc 360 tgcactgcca tctgccagcc tttgcgctac cccgttctca tgagctggag ggtgtgtgca 420 cagctggcag caacttgtat tgtcagtggc ttcctggtat ctctggtggg aacaacgttg 480 gtcttcagcc tccctttctg tggctccaat agggtcaacc actacttctg tgacatctcc 540 ccagtcatcc gacttgcctg tgctgaaacc tacatcaacg agctggtcat cttcgtctgt 600 ggtgtcctgg tgcttgttgt gcctttgatc ttcatctgta tctcttatgg cttcattgtc 660 cgcaccatcc tgaagatccc atctgctgat ggcaagcgaa aagccttctc cacctgtgcc 720

Page 2069

069269_0225_SL.TXT tcccatctta ttgtggtcat cgtccactat ggctgtgcct cctccgtcta cctgcggccc tcagccaaat cctcatcagg taaagacagg ctggtgacag tgacctacac tatcatcacc ccactgttga accctatggt atacagcctt aggaacaaag atgtacagct ggccattcgg aaagtgattg ggaagactgc ggtttctctt aagactttat ag

780

840

900

942 <210> 1846 <211> 313 <212> PRT <213> Canis familiaris <400> 1846

Met Ala 1 Asn Ser Ser Arg Val Thr Glu Phe Leu Leu Leu Gly Phe 15 Ser 5 10 Ser Phe Gly Glu Leu Gln Pro Val Leu Phe Val Leu Phe Leu Ser Leu 20 25 30 Tyr Leu Ile Ile Leu Ser Gly Asn Phe Thr Ile Ile Ser Val Ile Arg 35 40 45 Leu Asp Arg Ser Leu His Thr Pro Met Tyr Phe Phe Leu Cys Val Leu 50 55 60 Ser Thr Ser Glu Val Phe Tyr Thr Ile Val Ile Leu Pro Lys Met Leu 65 70 75 80 Ile Asn Leu Leu Ser Val Leu Arg Thr Leu Ser Phe Thr Ser Cys Ala 85 90 95 Thr Gln Met Phe Phe Phe Leu Gly Phe Gly Ile Thr Asn Cys Leu Leu 100 105 110 Leu Gly Val Met Gly Tyr Asp Arg Cys Thr Ala Ile Cys Gln Pro Leu 115 120 125 Arg Tyr Pro Val Leu Met Ser Trp Arg Val Cys Ala Gln Leu Ala Ala 130 135 140

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Thr 145 Cys Ile Val Ser Gly 150 Phe Leu Val Ser Leu Val Gly Thr Thr Leu 155 160 Val Phe Ser Leu Pro Phe Cys Gly Ser Asn Arg Val Asn His Tyr Phe 165 170 175 Cys Asp Ile Ser Pro Val Ile Arg Leu Ala Cys Ala Glu Thr Tyr Ile 180 185 190 Asn Glu Leu Val Ile Phe Val Cys Gly Val Leu Val Leu Val Val Pro 195 200 205 Leu Ile Phe Ile Cys Ile Ser Tyr Gly Phe Ile Val Arg Thr Ile Leu 210 215 220 Lys Ile Pro Ser Ala Asp Gly Lys Arg Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Ile Val Val Ile Val His Tyr Gly Cys Ala Ser Ser Val 245 250 255 Tyr Leu Arg Pro Ser Ala Lys Ser Ser Ser Gly Lys Asp Arg Leu Val 260 265 270 Thr Val Thr Tyr Thr Ile Ile Thr Pro Leu Leu Asn Pro Met Val Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Gln Leu Ala Ile Arg Lys Val Ile Gly 290 295 300 Lys Thr Ala Val Ser Leu Lys Thr Leu 305 310

<210> 1847 <211> 240 <212> DNA <213> Canis familiaris <400> 1847 aggtacaagg ccttctccac ctgtgcctcc cacctcattg tggttactgt gcattacggt

Page 2071

069269_0225_SL.TXT tgtgcctctt atatctgtgt aaccaggaat tcatctactt cctacaccat tcaaggcagc aaggcccaaa cctcattgta ctttcgaaga tccagctact cttttcaatc gtaatgggcc cttcaagtca caatgattaa agacttcgta ggacacgctc cagcctgagg tcctcttcac

120

180

240 <210> 1848 <211> 80 <212> PRT <213> Canis familiaris

<400> 1848 Phe Ser 5 Thr Cys Ala Ser His 10 Leu Ile Val Val Thr 15 Arg Tyr 1 Lys Ala Val His Tyr Gly Cys Ala Ser Phe Ile Tyr Leu Arg Pro Lys Ser Ser 20 25 30 Tyr Ser Ser Ser Gln Asp Thr Leu Ile Ser Val Ser Tyr Thr Ile Leu 35 40 45 Ile Val Leu Phe Asn Pro Met Ile Asn Ser Leu Arg Asn Gln Glu Phe 50 55 60 Lys Ala Ala Phe Arg Arg Val Met Gly Gln Thr Ser Tyr Pro Leu His 65 70 75 80

<210> 1849 <211> 942 <212> DNA <213> Canis <400> 1849 atggccaatt ttgcaacctg ttcaccatca ctctgtgtcc attaacctgc ttcttccttg tacactgcca familiaris cttcccgggt tgctctttgt tctcggtcat tgtccacctc tctctgtcct gctttgctgt tctgccagcc cactgagttc gctctttctc ccgcctggac ggaagtcttc caggacactc cacgaactgc tttgcgctac ctgctgctcg ggcctctact cgcagcctcc tacacaattg tccttcacca ctgcttctgg cccgttctca gtttctccag tgatcatcct acacgcccat ttatcctgcc gctgtgccac gagttatggg tgagctggag ctttggcgaa gagtggaaac gtacttcttt caagatgctt acagatgttc ttatgaccgc ggtgtgtgca

120

180

240

300

360

420

Page 2072

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cagctggcag caacttgtat tgtcagtggc ttcctggtat ctctggtggc aacaacgttg 480 gtcttcagcc tccctttctg tggctccaac agggtcaacc actacttctg tgacatctcc 540 ccagtcatcc gacttgcctg tgctgaaacc tacatcaacg agctggtcat cttcatctgt 600 ggtgtcctgg tgcttgttgt gcccttgatc ttcatctgca tctcctatgg cttcattgtc 660 cgcaccatcc tgaagatccc atctgctgat ggcaagcgaa aagccttctc cacctgcgcc 720 tcccatctta ttgtggtcat cgtccactat ggctgtgcct cctccgtcta cctgcggccc 780 tcagccaaat cctcatcagg taaagacagg ctggtgacag tgacctacac tatcatcacc 840 ccactgttga accctatggt atacagcctt aggaacaaag atgtacagct ggccattcgg 900 aaagtgatta ggaagactgc ggtttctctt aagactttat ag 942

<210> 1850 <211> 313 <212> PRT <213> Canis familiaris

<400> 1850 Arg Val Thr Glu Phe Leu Leu Leu Gly Phe Ser Met Ala 1 Asn Ser Ser 5 10 15 Ser Phe Gly Glu Leu Gln Pro Val Leu Phe Val Leu Phe Leu Gly Leu 20 25 30 Tyr Leu Ile Ile Leu Ser Gly Asn Phe Thr Ile Ile Ser Val Ile Arg 35 40 45 Leu Asp Arg Ser Leu His Thr Pro Met Tyr Phe Phe Leu Cys Val Leu 50 55 60 Ser Thr Ser Glu Val Phe Tyr Thr Ile Val Ile Leu Pro Lys Met Leu 65 70 75 80 Ile Asn Leu Leu Ser Val Leu Arg Thr Leu Ser Phe Thr Ser Cys Ala 85 90 95 Thr Gln Met Phe Phe Phe Leu Gly Phe Ala Val Thr Asn Cys Leu Leu 100 105 110

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Leu Gly Val 115 Met Gly Tyr Asp Arg Tyr Thr Ala Ile Cys Gln Pro Leu 120 125 Arg Tyr Pro Val Leu Met Ser Trp Arg Val Cys Ala Gln Leu Ala Ala 130 135 140 Thr Cys Ile Val Ser Gly Phe Leu Val Ser Leu Val Ala Thr Thr Leu 145 150 155 160 Val Phe Ser Leu Pro Phe Cys Gly Ser Asn Arg Val Asn His Tyr Phe 165 170 175 Cys Asp Ile Ser Pro Val Ile Arg Leu Ala Cys Ala Glu Thr Tyr Ile 180 185 190 Asn Glu Leu Val Ile Phe Ile Cys Gly Val Leu Val Leu Val Val Pro 195 200 205 Leu Ile Phe Ile Cys Ile Ser Tyr Gly Phe Ile Val Arg Thr Ile Leu 210 215 220 Lys Ile Pro Ser Ala Asp Gly Lys Arg Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Ile Val Val Ile Val His Tyr Gly Cys Ala Ser Ser Val 245 250 255 Tyr Leu Arg Pro Ser Ala Lys Ser Ser Ser Gly Lys Asp Arg Leu Val 260 265 270 Thr Val Thr Tyr Thr Ile Ile Thr Pro Leu Leu Asn Pro Met Val Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Gln Leu Ala Ile Arg Lys Val Ile Arg 290 295 300 Lys Thr Ala Val Ser Leu Lys Thr Leu 305 310

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069269_0225_SL.TXT <210> 1851 <211> 942 <212> DNA <213> Canis familiaris <400> 1851

atggccaatt cttcccgggt cactgagttc ctgctgctcg gtttctccgg ctttggcgaa 60 ttgcaacctg tgctctttgt gctctttctc ggcctctact tgatcatcct gagtggaaac 120 ttcaccatca tctccgtcat ccgcctggac cgcagcctcc acacgcccat gtacttcttt 180 ctctgtgtcc tgtccacctc ggaagtcttc tacacaattg ttatcctgcc caagatgctt 240 attaacctgc tctctgtcct caggacactc tccttcacca gctgtgccac acagatgttc 300 ttcttccttg gctttgctgt cacgaactgc ctgcttctgg gagttatggg ttatgaccgc 360 tacactgcca tctgccagcc tttgcgctac cccgttctca tgagctggag ggtgtgtgca 420 cagctggcag caacttgtat tgtcagtggc ttcctgatat ctctggtggg aacaacgttg 480 gtcttcagcc tccctttctg tggctccaat agggtcaacc actacttctg tgacatctcc 540 ccagtcatcc gacttgcctg tgctgaaacc tacatcaacg agctggtcat cttcatctgt 600 ggtgtcctgg tgcttgttgt gcctttgatc ttcatctgta tctcttatgg cttcattgtc 660 cgcaccatcc tgaagatccc atctgctgat ggcaagcgaa aagccttctc cacctgcgcc 720 tcccatctta ttgtggtcat cgtccactat ggctgtgcct cctccgtcta cctgcggccc 780 tcagccaaat cctcatcagg taaagacagg ctggtgacag tgacctacac tatcatcacc 840 ccactgttga accctatggt atacagcctt aggaacaaag atgtacagct ggccattcgg 900 aaagtgattg ggaagactgc ggtttctctt aagactttat ag 942

<210> 1852 <211> 313 <212> PRT <213> Canis familiaris <400> 1852

Met Ala Asn Ser Ser Arg Val Thr Glu Phe Leu Leu Leu Gly Phe Ser

1 5 10 15

Gly Phe Gly Glu Leu Gln Pro Val Leu Phe Val Leu Phe Leu Gly Leu

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069269_0225_SL.TXT 25 30

Tyr Leu Ile 35 Ile Leu Ser Gly Asn Phe Thr Ile Ile Ser Val Ile Arg 40 45 Leu Asp Arg Ser Leu His Thr Pro Met Tyr Phe Phe Leu Cys Val Leu 50 55 60 Ser Thr Ser Glu Val Phe Tyr Thr Ile Val Ile Leu Pro Lys Met Leu 65 70 75 80 Ile Asn Leu Leu Ser Val Leu Arg Thr Leu Ser Phe Thr Ser Cys Ala 85 90 95 Thr Gln Met Phe Phe Phe Leu Gly Phe Ala Val Thr Asn Cys Leu Leu 100 105 110 Leu Gly Val Met Gly Tyr Asp Arg Tyr Thr Ala Ile Cys Gln Pro Leu 115 120 125 Arg Tyr Pro Val Leu Met Ser Trp Arg Val Cys Ala Gln Leu Ala Ala 130 135 140 Thr Cys Ile Val Ser Gly Phe Leu Ile Ser Leu Val Gly Thr Thr Leu 145 150 155 160 Val Phe Ser Leu Pro Phe Cys Gly Ser Asn Arg Val Asn His Tyr Phe 165 170 175 Cys Asp Ile Ser Pro Val Ile Arg Leu Ala Cys Ala Glu Thr Tyr Ile 180 185 190 Asn Glu Leu Val Ile Phe Ile Cys Gly Val Leu Val Leu Val Val Pro 195 200 205 Leu Ile Phe Ile Cys Ile Ser Tyr Gly Phe Ile Val Arg Thr Ile Leu 210 215 220 Lys Ile Pro Ser Ala Asp Gly Lys Arg Lys Ala Phe Ser Thr Cys Ala

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225 230 His Tyr 250 235 240 Ser His Leu Ile Val 245 Val Ile Val Gly Cys Ala Ser Ser 255 Val Tyr Leu Arg Pro Ser Ala Lys Ser Ser Ser Gly Lys Asp Arg Leu Val 260 265 270 Thr Val Thr Tyr Thr Ile Ile Thr Pro Leu Leu Asn Pro Met Val Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Gln Leu Ala Ile Arg Lys Val Ile Gly 290 295 300 Lys Thr Ala Val Ser Leu Lys Thr Leu 305 310

<210> 1853 <211> 942 <212> DNA <213> Canis familiaris <400> 1853

atggagcggg gcaacgagac cctggtgagg gagttcatct tccttggctt ctcttctctg 60 gccgggctgc agcggctgct cttcgtcgcc ttcctgcccc tctacctgtt cactctgggc 120 accaatgcca tcatcatttc caccatcgtg ctggacagag ccctgcacac ccccatgtac 180 ttcttcctgg ccgtcctctc ctgctccgag acctgctaca cctttgtcat cgtccccaag 240 atgctggtgg acctgctggc ccagaagaag accatctcct tcgtgggctg tgccatccag 300 atgttcacct tcctcttcct cggctgctct cactccttcc tgctggcagc catggggtat 360 gaccgctacg tggccatctg taaccctctg cgttacacag agctcatggg acctcgggtg 420 tgtgtgggac tcgtggctgc tgcctgtgcc tgtggcttga ctattgccca gattgtcacc 480 tccctggtgt ttcacctgcc cttcctctcc tccaaccagc tgcatcacta cttctgcgac 540 atctctcctg tcctcaaggt ggcgtcccat cactcgcgcc tcagtcagtt ggtcatattc 600 atgattggtg tgtgtgtgtt ggtcgtcccc ctcctcctca tcctggtctc ttacatccgc 660 atcatttctg ccattttgaa gatcccatcc tccaccggca ggtacaaggc cttctccacc 720

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tgtgcctccc acctcattgt ggttactgtg cattacggtt gtgcctcttt catctactta 780 aggcccaaat ccagctactc ttcaagtcag gacacgctca tatctgtgtc ctacaccatc 840 ctcactccac tcttcaatcc aatgatttat agcctgagga accaggaatt caaggcagcc 900 tttcgaagag taatgggcca gactttgtat cctcctcact aa 942

<210> 1854 <211> 313 <212> PRT <213> Canis familiaris <400> 1854

Met Glu Arg 1 Gly Asn Glu Thr Leu 5 Val Arg Glu Phe Ile Phe Leu Gly 10 15 Phe Ser Ser Leu Ala Gly Leu Gln Arg Leu Leu Phe Val Ala Phe Leu 20 25 30 Pro Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Ile Ser Thr 35 40 45 Ile Val Leu Asp Arg Ala Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Val Leu Ser Cys Ser Glu Thr Cys Tyr Thr Phe Val Ile Val Pro Lys 65 70 75 80 Met Leu Val Asp Leu Leu Ala Gln Lys Lys Thr Ile Ser Phe Val Gly 85 90 95 Cys Ala Ile Gln Met Phe Thr Phe Leu Phe Leu Gly Cys Ser His Ser 100 105 110 Phe Leu Leu Ala Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Thr Glu Leu Met Gly Pro Arg Val Cys Val Gly Leu 130 135 140

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Val 145 Ala Ala Ala Cys Ala 150 Cys Gly Leu Thr Ile Ala Gln Ile Val Thr 155 160 Ser Leu Val Phe His Leu Pro Phe Leu Ser Ser Asn Gln Leu His His 165 170 175 Tyr Phe Cys Asp Ile Ser Pro Val Leu Lys Val Ala Ser His His Ser 180 185 190 Arg Leu Ser Gln Leu Val Ile Phe Met Ile Gly Val Cys Val Leu Val 195 200 205 Val Pro Leu Leu Leu Ile Leu Val Ser Tyr Ile Arg Ile Ile Ser Ala 210 215 220 Ile Leu Lys Ile Pro Ser Ser Thr Gly Arg Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ile Val Val Thr Val His Tyr Gly Cys Ala Ser 245 250 255 Phe Ile Tyr Leu Arg Pro Lys Ser Ser Tyr Ser Ser Ser Gln Asp Thr 260 265 270 Leu Ile Ser Val Ser Tyr Thr Ile Leu Thr Pro Leu Phe Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Phe Lys Ala Ala Phe Arg Arg Val 290 295 300 Met Gly Gln Thr Leu Tyr Pro Pro His 305 310

<210> 1855 <211> 945 <212> DNA <213> Canis familiaris <400> 1855 atgaggagac agaaccagag catgattacg gagttcatcc ttatcggctt ctcaaacctg

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ggagatctgc agatccttct cttcttcctc ttcctcctgg tttacctgac cactctgatg 120 gccaatgcca ccatcatgac tgtcatccgt ctggacagga ctttgcacac ccctatgtac 180 ttctttctct ttgtcctctc ctgctctgaa acctgctaca ccttggtcat tgtaccaaaa 240 atgctgacca acctgctttc cacgagtcag actatttctt ttcctgcgtg tgctgctcag 300 ctctacttct tcgtgggctt ggcttgtacc aactgttttc tcattgccgt aatgggctac 360 gaccgctacg ttgccatctg caaccctctc aactacacgc ttgttgtcag cagagccacc 420 tgtgtgcaac tggtcctagc ctccagctgc tgtggcttcc tgatctctgt ggttgttaat 480 gtcttggtgt ttagtgtgcc cttctgtgcc tccaatcgga tcaaccactt tttctgtgat 540 attttcccag tcatcaaact aggctgcact gacaccaacg tgaaggagat ggtcatcttc 600 ttcctcagca ttctggtatt gctggtcccc ctagtgctga tcttcatctc ctacgtcttc 660 attgtctcca ccatcctcaa gattgcatcc gccgaggggc agcggaaggc ctttgctacc 720 tgtgcctccc acctcacagt ggtcatcgtc cactatggct gcgcctcctt catctacctg 780 aggcccacat ccctgtactc ctcagaaaag gaccggctcg tggcagtgac ctacactgtg 840 atcaccccgc tgcttaaccc ccttgtctac accctgagaa ataaagaagt caagactgca 900 ctgagtaagg ttctcagcag gtactcattc cccaaaactg tatga <210> 1856 <211> 314 <212> PRT <213> Canis familiaris <400> 1856 945 Met Arg Arg Gln Asn Gln Ser Met Ile Thr Glu Phe Ile Leu Ile Gly 1 5 10 15 Phe Ser Asn Leu Gly Asp Leu Gln Ile Leu Leu Phe Phe Leu Phe Leu 20 25 30 Leu Val Tyr Leu Thr Thr Leu Met Ala Asn Ala Thr Ile Met Thr Val 35 40 45 Ile Arg Leu Asp Arg Thr Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60

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Val 65 Leu Ser Cys Ser Glu Thr Cys Tyr Thr Leu Val Ile Val Pro Lys 70 75 80 Met Leu Thr Asn Leu Leu Ser Thr Ser Gln Thr Ile Ser Phe Pro Ala 85 90 95 Cys Ala Ala Gln Leu Tyr Phe Phe Val Gly Leu Ala Cys Thr Asn Cys 100 105 110 Phe Leu Ile Ala Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Asn Tyr Thr Leu Val Val Ser Arg Ala Thr Cys Val Gln Leu 130 135 140 Val Leu Ala Ser Ser Cys Cys Gly Phe Leu Ile Ser Val Val Val Asn 145 150 155 160 Val Leu Val Phe Ser Val Pro Phe Cys Ala Ser Asn Arg Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Phe Pro Val Ile Lys Leu Gly Cys Thr Asp Thr 180 185 190 Asn Val Lys Glu Met Val Ile Phe Phe Leu Ser Ile Leu Val Leu Leu 195 200 205 Val Pro Leu Val Leu Ile Phe Ile Ser Tyr Val Phe Ile Val Ser Thr 210 215 220 Ile Leu Lys Ile Ala Ser Ala Glu Gly Gln Arg Lys Ala Phe Ala Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ile Val His Tyr Gly Cys Ala Ser 245 250 255 Phe Ile Tyr Leu Arg Pro Thr Ser Leu Tyr Ser Ser Glu Lys Asp Arg 260 265 270

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Leu Val Ala Val Thr Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Leu 275 280 285 Val Tyr Thr Leu Arg Asn Lys Glu Val Lys Thr Ala Leu Ser Lys Val 290 295 300 Leu Ser Arg Tyr Ser Phe Pro Lys Thr Val 305 310

<210> 1857 <211> 945 <212> DNA <213> Canis familiaris <400> 1857

atggagcagg gcaatgagac cctggtgagg gagttcatct tccttggctt ctcttctctg 60 gccgggctgc agcggctgct cttcgtcgcc ttcctgcccc tctacctgtt cactctgggc 120 accaatgcca tcatcatttc caccatcgtg ctggacagag ccctgcacac ccccatgtac 180 ttcttcctgg ccgtcctctc ctgctccgag acctgctaca cctttgtcat cgtccccaag 240 atgctggtgg acctgctggc ccagaagaag accatctcct tcgtgggctg tgccatccag 300 atgttcacct tcctcttcct cggctgctct cactccttcc tgctggcagc catggggtat 360 gaccgctacg tggccatctg taaccctctg cgctacacag agctcatggg acaccgggtg 420 tgtgtgggac tcgtggccac tgcctgtgcc tgtggcttga ctattgcaca gattatcacc 480 tccctggtgt tttacctgcc gttccgctcc tccaaccagc tccatcacta cttctgcgac 540 atccctcctg tcctcaaagt ggcatctcaa catacccact tgagtcagat tgtcattatc 600 atgctctgtg cattggtcct ggttatccct ctgctactga ttttggtatc ctatattcac 660 atcatctctg ccatcatcca atttccttcc acattaggca gatacaaagc tttctccacc 720 tgtgcgtccc acctcattgt tgtcaccatt cattatggtt gcgcctcctt tatctactta 780 aggctcaagt ccacctactc ctcaagccag gatgctctca tatcagtctc ctacaccatg 840 ctcactccac tgttcaaccc actgatttat agcctcagaa ataaagagtt caggtcagcg 900 cttcacagag ctgtgcgaaa aatcattttc ctgccacaat gttaa 945

Page 2082

069269_0225_SL.TXT <210> 1858 <211> 314 <212> PRT <213> Canis familiaris

<400> 1858 Gly Met 1 Glu Gln Gly Asn Glu Thr Leu 5 Val Arg 10 Glu Phe Ile Phe Leu 15 Phe Ser Ser Leu Ala Gly Leu Gln Arg Leu Leu Phe Val Ala Phe Leu 20 25 30 Pro Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Ile Ser Thr 35 40 45 Ile Val Leu Asp Arg Ala Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Val Leu Ser Cys Ser Glu Thr Cys Tyr Thr Phe Val Ile Val Pro Lys 65 70 75 80 Met Leu Val Asp Leu Leu Ala Gln Lys Lys Thr Ile Ser Phe Val Gly 85 90 95 Cys Ala Ile Gln Met Phe Thr Phe Leu Phe Leu Gly Cys Ser His Ser 100 105 110 Phe Leu Leu Ala Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Thr Glu Leu Met Gly His Arg Val Cys Val Gly Leu 130 135 140 Val Ala Thr Ala Cys Ala Cys Gly Leu Thr Ile Ala Gln Ile Ile Thr 145 150 155 160 Ser Leu Val Phe Tyr Leu Pro Phe Arg Ser Ser Asn Gln Leu His His 165 170 175 Tyr Phe Cys Asp Ile Pro Pro Val Leu Lys Val Ala Ser Gln His Thr 180 185 190

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His Leu Ser 195 Gln Ile Val Ile Ile Met 200 Leu Cys Ala Leu 205 Val Leu Val Ile Pro Leu Leu Leu Ile Leu Val Ser Tyr Ile His Ile Ile Ser Ala 210 215 220 Ile Ile Gln Phe Pro Ser Thr Leu Gly Arg Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ile Val Val Thr Ile His Tyr Gly Cys Ala Ser 245 250 255 Phe Ile Tyr Leu Arg Leu Lys Ser Thr Tyr Ser Ser Ser Gln Asp Ala 260 265 270 Leu Ile Ser Val Ser Tyr Thr Met Leu Thr Pro Leu Phe Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Phe Arg Ser Ala Leu His Arg Ala 290 295 300 Val Arg Lys Ile Ile Phe Leu Pro Gln Cys

305 310 <210> 1859 <211> 948 <212> DNA <213> Canis familiaris <400> 1859

atgcacagtt tcaatagaac cactatggtt acacggtttg tcctggtggg cttctctagc 60 ctgggggagc tccagctact gctgtttgtc atcttccttc tcctgtattt gacaatccta 120 ctggccaatg caaccatcat ggctgttatc cgctgcagcc ggactctaca cactcccatg 180 tatggtttct tattcatcct ttccttttct gagtcctgct acacatttgt catcatccct 240 cagctgctgg tccacctgct ctcagccacc aagagcatct cctttgtggc ctgtgctgcc 300 cagcttttct tcttccttgg ctttgcctgc accaactgct ttctcatcgc tgtgatgggg 360

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tatgaccgct acgtggcaat ttgccagcct ctgaggtata cacttgtcat gaacaaaagg 420 ctagggttgg ggttggtttc cctgtctgga gtcacaggtt tcttcattgc tttggtggcc 480 accaatctca tctgtgacat gcccttctgt ggccccaaca gggtcaacca ctacttctgt 540 gacatggcac ctgttattaa gttggcctgc acagacaccc atgtgaaaga actggctcta 600 ttcagcctca gcatcttggt gatcatggtg cctttcctgc taattctcat ctcctatggc 660 ttcatcctta ataccatcct gaagatcccc tcggctgagg gaaaaaggaa ggcctttgcc 720 acctgcgcct cccacctcac agtggtcatc gtgcactacg gctgtgcgtc catcatctac 780 ctgaggccca gatccaagtc tgcctcagac aaggatcagt tggtggcagt gacctatact 840 gtggttactc ccctacttaa tccccttgtc tacagtctga ggaatcagga ggtgaagact 900 gccctcaaaa gagttctggg gatgcctgtg gcaaccaaag taatctaa 948

<210> 1860 <211> 315 <212> PRT <213> Canis familiaris

<400> 1860 Asn Arg 5 Thr Thr Met Val Thr Arg Phe Val Leu Val Met His 1 Ser Phe 10 15 Gly Phe Ser Ser Leu Gly Glu Leu Gln Leu Leu Leu Phe Val Ile Phe 20 25 30 Leu Leu Leu Tyr Leu Thr Ile Leu Leu Ala Asn Ala Thr Ile Met Ala 35 40 45 Val Ile Arg Cys Ser Arg Thr Leu His Thr Pro Met Tyr Gly Phe Leu 50 55 60 Phe Ile Leu Ser Phe Ser Glu Ser Cys Tyr Thr Phe Val Ile Ile Pro 65 70 75 80 Gln Leu Leu Val His Leu Leu Ser Ala Thr Lys Ser Ile Ser Phe Val 85 90 95

Ala Cys Ala Ala Gln Leu Phe Phe Phe Leu Gly Phe Ala Cys Thr Asn Page 2085

100

069269_0225_SL.TXT 105 110

Cys Phe Leu 115 Ile Ala Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys 120 125 Gln Pro Leu Arg Tyr Thr Leu Val Met Asn Lys Arg Leu Gly Leu Gly 130 135 140 Leu Val Ser Leu Ser Gly Val Thr Gly Phe Phe Ile Ala Leu Val Ala 145 150 155 160 Thr Asn Leu Ile Cys Asp Met Pro Phe Cys Gly Pro Asn Arg Val Asn 165 170 175 His Tyr Phe Cys Asp Met Ala Pro Val Ile Lys Leu Ala Cys Thr Asp 180 185 190 Thr His Val Lys Glu Leu Ala Leu Phe Ser Leu Ser Ile Leu Val Ile 195 200 205 Met Val Pro Phe Leu Leu Ile Leu Ile Ser Tyr Gly Phe Ile Leu Asn 210 215 220 Thr Ile Leu Lys Ile Pro Ser Ala Glu Gly Lys Arg Lys Ala Phe Ala 225 230 235 240 Thr Cys Ala Ser His Leu Thr Val Val Ile Val His Tyr Gly Cys Ala 245 250 255 Ser Ile Ile Tyr Leu Arg Pro Arg Ser Lys Ser Ala Ser Asp Lys Asp 260 265 270 Gln Leu Val Ala Val Thr Tyr Thr Val Val Thr Pro Leu Leu Asn Pro 275 280 285 Leu Val Tyr Ser Leu Arg Asn Gln Glu Val Lys Thr Ala Leu Lys Arg 290 295 300 Val Leu Gly Met Pro Val Ala Thr Lys Val Ile

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305 310 315 <210> 1861 <211> 900 <212> DNA <213> Canis familiaris <400> 1861

agacaccaca cttccagcac tgggttgatc ttccagggct tctcgagctt ctgcggacac 60 cagctcaccc cgttcgccgt gttccttgtg ctctacacct tcacccaggg tggcaacgtc 120 gtcatcgtga ccgttgcctc cgaccgttgc ctccacatgc ccatgtactt cttcctgaac 180 acgctgtccg cctccgagat ggtctacatc cttgtcattc tcccatggat gctctccagc 240 ctcgcgggta tgagccaggc catctcacag gcaggctgtg tcaaccagat gttctttttt 300 gtaaccttgg gcatcaacaa ctgcttcctg ctcatggcca tgggctacga ctactacatg 360 gccatctgca accccttgag atactcagtt attatcaaca agagaaagcg tgtccagctg 420 gtggggggag cctgcagcat tgggttgatg gtagcaatca cacaagtgac atctgtgttc 480 aggctgccct tctgtgccac gagggtggcc cacttcttct gtgacatccg acccgtgatg 540 aagctctcct gcatcaacac cacagccaat gagatcctga ctctgatcat cagtgtgctg 600 gtgatcctgg tgcccatggg gctggtcttc gtctcctatg tcctcatcat ctccaccatc 660 ttcaagatcc cctctgcaca ggggtcacct gagcctccca cctcaccatg gtcattgtcc 720 attatggctg cgcctccatc gcctacctca agcccaagtc ggagaacacc agggatgagg 780 accagcttga cctcggtgac ctacacagtc atcaccctgc tgctgaaccc tgtggtgtac 840 accctgagga acgaggaggt caaggatgct ctgctccggg ccactggcag gaagctttcc 900

<210> 1862 <211> 300 <212> PRT <213> Canis familiaris <400> 1862

Arg His His Thr Ser Ser Thr Gly Leu Ile Phe Gln Gly Phe Ser Ser 1 5 10 15

Phe Cys Gly His Gln Leu Thr Pro Phe Ala Val Phe Leu Val Leu Tyr 20 25 30

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Thr Phe Thr 35 Gln Gly Gly Asn Val Val Ile Val Thr Val Ala Ser Asp 40 45 Arg Cys Leu His Met Pro Met Tyr Phe Phe Leu Asn Thr Leu Ser Ala 50 55 60 Ser Glu Met Val Tyr Ile Leu Val Ile Leu Pro Trp Met Leu Ser Ser 65 70 75 80 Leu Ala Gly Met Ser Gln Ala Ile Ser Gln Ala Gly Cys Val Asn Gln 85 90 95 Met Phe Phe Phe Val Thr Leu Gly Ile Asn Asn Cys Phe Leu Leu Met 100 105 110 Ala Met Gly Tyr Asp Tyr Tyr Met Ala Ile Cys Asn Pro Leu Arg Tyr 115 120 125 Ser Val Ile Ile Asn Lys Arg Lys Arg Val Gln Leu Val Gly Gly Ala 130 135 140 Cys Ser Ile Gly Leu Met Val Ala Ile Thr Gln Val Thr Ser Val Phe 145 150 155 160 Arg Leu Pro Phe Cys Ala Thr Arg Val Ala His Phe Phe Cys Asp Ile 165 170 175 Arg Pro Val Met Lys Leu Ser Cys Ile Asn Thr Thr Ala Asn Glu Ile 180 185 190 Leu Thr Leu Ile Ile Ser Val Leu Val Ile Leu Val Pro Met Gly Leu 195 200 205 Val Phe Val Ser Tyr Val Leu Ile Ile Ser Thr Ile Phe Lys Ile Pro 210 215 220 Ser Ala Gln Gly Ser Pro Glu Pro Pro Thr Ser Pro Trp Ser Leu Ser 225 230 235 240

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Ile Met Ala Ala Pro Pro Ser Pro Thr Ser Ser Pro Ser Arg Arg Thr 245 250 255 Pro Gly Met Arg Thr Ser Leu Thr Ser Val Thr Tyr Thr Val Ile Thr 260 265 270 Leu Leu Leu Asn Pro Val Val Tyr Thr Leu Arg Asn Glu Glu Val Lys 275 280 285 Asp Ala Leu Leu Arg Ala Thr Gly Arg Lys Leu Ser

290 295 300 <210> 1863 <211> 936 <212> DNA <213> Canis familiaris <400> 1863

atgccgaagc ccaacaccac tgctgtgacg gagtttacct tcgaaggctt ttccgctttg 60 gggtggcagc gcagactcct cctcttcgtg gtctttctgg ccttgcacct ggtgaccctt 120 ggcagcaatg ccctcatcct ggcggctgtt cgcctgagcc gtcacctcca cacccccatg 180 tacttcctcc tgagcgcgct gtccctctct gagacctgct acagcgtggc catcgtcccc 240 cgcatgctct ccggtctcct gagcccccgg gaggccgtct ccgttgcggg ctgtgccact 300 cagctcttct tctatctcac ctttggcgtc accaactgct tcctgctcgc ggccatgggc 360 tacgaccgct acgtggccat ctgcgacccc ctgcggtatg cggtcgtcat gggccaaagg 420 acctgtgtgc acctggcgtg tggctcctgg agcgtgggcc tgagcacagc catcatccag 480 gtgtcttccg tgttcagcct gcccttctgt gacgccagcg tcatctccca ttttttctgc 540 gacatccggc ccctcatgaa gctggcctgt gccgacacca ccatcaaaga gcttctcact 600 ttgctcatca gtctgtgcgt gctcgtcttg cccatggtcc tcatcttcat ctcctatgtc 660 ctgatcgtct ccaccatcct caagatggca tcagctgagg gccagaggaa ggctttcgcc 720 acctgcgcct cccacctcac cgtggtcatc gtccactatg gctgcacctc cttcatctac 780 ctaaaaccca aatcgcaaaa ttccctgcag gacagactcc tctctgtgac ctacacggtc 840

Page 2089

900

936

069269_0225_SL.TXT atcacgcccc tgctgaaccc cgtggtctac ggcctgagga acaaggaggt caagcaggcc ttgctccgag ctgtgggcag gaagcctctc ccgtag <210> 1864 <211> 311 <212> PRT <213> Canis familiaris <400> 1864

Met Pro Lys Pro Asn Thr Thr Ala Val Thr Glu Phe Thr Phe Glu Gly 1 5 10 15 Phe Ser Ala Leu Gly Trp Gln Arg Arg Leu Leu Leu Phe Val Val Phe 20 25 30 Leu Ala Leu His Leu Val Thr Leu Gly Ser Asn Ala Leu Ile Leu Ala 35 40 45 Ala Val Arg Leu Ser Arg His Leu His Thr Pro Met Tyr Phe Leu Leu 50 55 60 Ser Ala Leu Ser Leu Ser Glu Thr Cys Tyr Ser Val Ala Ile Val Pro 65 70 75 80 Arg Met Leu Ser Gly Leu Leu Ser Pro Arg Glu Ala Val Ser Val Ala 85 90 95 Gly Cys Ala Thr Gln Leu Phe Phe Tyr Leu Thr Phe Gly Val Thr Asn 100 105 110 Cys Phe Leu Leu Ala Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asp Pro Leu Arg Tyr Ala Val Val Met Gly Gln Arg Thr Cys Val His 130 135 140 Leu Ala Cys Gly Ser Trp Ser Val Gly Leu Ser Thr Ala Ile Ile Gln 145 150 155 160 Val Ser Ser Val Phe Ser Leu Pro Phe Cys Asp Ala Ser Val Ile Ser

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165 170 175

His Phe Phe Cys Asp Ile Arg Pro Leu Met 185 Lys Leu Ala Cys Ala Asp 190 180 Thr Thr Ile Lys Glu Leu Leu Thr Leu Leu Ile Ser Leu Cys Val Leu 195 200 205 Val Leu Pro Met Val Leu Ile Phe Ile Ser Tyr Val Leu Ile Val Ser 210 215 220 Thr Ile Leu Lys Met Ala Ser Ala Glu Gly Gln Arg Lys Ala Phe Ala 225 230 235 240 Thr Cys Ala Ser His Leu Thr Val Val Ile Val His Tyr Gly Cys Thr 245 250 255 Ser Phe Ile Tyr Leu Lys Pro Lys Ser Gln Asn Ser Leu Gln Asp Arg 260 265 270 Leu Leu Ser Val Thr Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Val 275 280 285 Val Tyr Gly Leu Arg Asn Lys Glu Val Lys Gln Ala Leu Leu Arg Ala 290 295 300 Val Gly Arg Lys Pro Leu Pro 305 310

<210> 1865 <211> 294 <212> DNA <213> Canis familiaris <400> 1865 cttcttactt cttacctctg tgacgtgaga cccctgctga agctggcctg catggacacc actgtcaatg agatcatcaa ctttgttgtc agtatctgtg tcctggttct actcatgggc ctggtcttca tctcctatgt ccccatcatc tccaccatcc ttaagatcac ttcagctgag agccagaagg cctctgccac ctgcgcctcc cacctcaccg tggtcatcgt cctctatggc

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069269_0225_SL.TXT tgcacttcca tcatccacct caagcccaag tcccagagtt ccctggggca ggac 294 <210> 1866 <211> 98 <212> PRT <213> Canis familiaris

<400> 1866 Tyr 5 Leu Cys Asp Val Arg Pro Leu 10 Leu Lys Leu 15 Ala Leu Leu 1 Thr Ser Cys Met Asp Thr Thr Val Asn Glu Ile Ile Asn Phe Val Val Ser Ile 20 25 30 Cys Val Leu Val Leu Leu Met Gly Leu Val Phe Ile Ser Tyr Val Pro 35 40 45 Ile Ile Ser Thr Ile Leu Lys Ile Thr Ser Ala Glu Ser Gln Lys Ala 50 55 60 Ser Ala Thr Cys Ala Ser His Leu Thr Val Val Ile Val Leu Tyr Gly 65 70 75 80 Cys Thr Ser Ile Ile His Leu Lys Pro Lys Ser Gln Ser Ser Leu Gly 85 90 95

Gln Asp <210> 1867 <211> 930 <212> DNA <213> Canis familiaris <400> 1867 atggagggaa agaatcacac tttggtgagc gagttcactt tccagggctt ctcgagcttc 60 ggcgagcacc agctcaccct gttcgttgtg ttccttgtgc tctacacctt caccctggct 120 ggcaacgtgg tcatcgtgac cgtcattagt gttgaccgcc gcctccacac gcccatgtac 180 ttcttcctga gcacgctgtc tgtttcggag accgtgtaca ccctcgtcat tatacccaag 240

Page 2092

069269_0225_SL.TXT atgctctgta acctcctagg cctgagtcag cccatctcct tggcaggttg tgccacccag atgttcttct tcatcacctt ggccatcaac aactgcttcc tgctcacggc catgggctac gaccgctacg tggccatctg tgaccccttg aggtacgcgg tcatcatgag caaaggaata tgcatccagt tggtgggggg agcctgcagc attggcctga tcgtagccat gacacaggtg ctggctgtgt tcaggctgcc cttctgtgcc acgagggtgg cccacttctt ctgtgacatc cgacccgtga tgaagctctc ctgcatcgac accacagcca atgagatcct gactctgatc atcagtgtgc tggtgatcct ggtgcccatg gggctggtct tcatctccta cgtcctcatc atctccacca tcctcaagat cccctctgcc cagggccgga agaaggcctt tgccacctgc gcctcccacc tcaccgtggt catcgtccac tacggctgcg cctccatcgc ctacctcaag cccaagtcgg agaactccag ggatgaggac cagctgatct cggtgaccta cacggtcatc accccgctgc tgaaccctgt ggtgtacacc ctgaggaaca aggaggtcaa ggatgctctg ctccgggcca ctggcaggaa gctttcctga <210> 1868 <211> 309 <212> PRT <213> Canis familiaris

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<400> 1868 Asn His 5 Thr Leu Val Ser Glu Phe Thr Phe Gln Gly Met Glu 1 Gly Lys 10 15 Phe Ser Ser Phe Gly Glu His Gln Leu Thr Leu Phe Val Val Phe Leu 20 25 30 Val Leu Tyr Thr Phe Thr Leu Ala Gly Asn Val Val Ile Val Thr Val 35 40 45 Ile Ser Val Asp Arg Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Thr Leu Ser Val Ser Glu Thr Val Tyr Thr Leu Val Ile Ile Pro Lys 65 70 75 80 Met Leu Cys Asn Leu Leu Gly Leu Ser Gln Pro Ile Ser Leu Ala Gly Page 2093

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85 90 95 Cys Ala Thr Gln Met Phe Phe Phe Ile Thr Leu Ala Ile Asn Asn Cys 100 105 110 Phe Leu Leu Thr Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asp 115 120 125 Pro Leu Arg Tyr Ala Val Ile Met Ser Lys Gly Ile Cys Ile Gln Leu 130 135 140 Val Gly Gly Ala Cys Ser Ile Gly Leu Ile Val Ala Met Thr Gln Val 145 150 155 160 Leu Ala Val Phe Arg Leu Pro Phe Cys Ala Thr Arg Val Ala His Phe 165 170 175 Phe Cys Asp Ile Arg Pro Val Met Lys Leu Ser Cys Ile Asp Thr Thr 180 185 190 Ala Asn Glu Ile Leu Thr Leu Ile Ile Ser Val Leu Val Ile Leu Val 195 200 205 Pro Met Gly Leu Val Phe Ile Ser Tyr Val Leu Ile Ile Ser Thr Ile 210 215 220 Leu Lys Ile Pro Ser Ala Gln Gly Arg Lys Lys Ala Phe Ala Thr Cys 225 230 235 240 Ala Ser His Leu Thr Val Val Ile Val His Tyr Gly Cys Ala Ser Ile 245 250 255 Ala Tyr Leu Lys Pro Lys Ser Glu Asn Ser Arg Asp Glu Asp Gln Leu 260 265 270 Ile Ser Val Thr Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Val Val 275 280 285 Tyr Thr Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Leu Arg Ala Thr

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290 295 300

Gly Arg Lys Leu Ser

305 <210> 1869 <211> 933 <212> DNA <213> Canis familiaris <400> 1869

atgaagacaa ccaaccacac agaagtgacg gagtttgttt tccaaggttt ctccaacttc 60 ggagaacatc aactcaccct ctttgccgtg tttctggccc tctacatccc aactctggct 120 ggcaatgtca tcatcgtgac tattatccat atcgaccacc acctccacac ccccatgtac 180 ttctttctga gtgttctttc cacgtcagag actttctact ccctggtcat tatcccacgc 240 atgctttcca gcctcatagg tctgagccaa tccatctccc tggtgggctg tgggactcag 300 ctctttttct tccttggctt tgccatcacc aactgtctcc tgctagcagt aatggggttt 360 gatcgttacg tggccatctg taaccctctt cgttattcga tcatcatgaa ttggagggtc 420 tgtaccattc tggcatcttc ggtctgtgcc tcagggttct tgctctccct ggttcaggct 480 gtggccattt tcagactgcc tttttgcaac tcactgattg agcatttctt ctgtgatgtt 540 cgacctgtgt tggacctggc ctgtgctact ccagtcatta atgacatcct gaccttagtt 600 ataagtctct tggccattac agcccctgcc accttcctct ttgtctccta catcctcatc 660 atctccacca tccttaagat cgcctcagcc gagggccgga agaaggcctt tgccacctgc 720 gcctcccacc tcaccgtggt catcatccac tacggctgcg cctccattgc ctacttcaag 780 cccaagtcgg agaacaccag ggatcaggac cagctgatct cagtgactta cacggtcata 840 acacctttac tgaaccctgt ggtgtatagt ctgagaaaca aagaagtcca ggatgctctg 900 aggagggtgg tgggtaggaa atcccttccc taa 933

<210> 1870 <211> 310 <212> PRT <213> Canis familiaris <400> 1870

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Met 1 Lys Thr Thr Asn His Thr Glu Val Thr Glu Phe Val Phe Gln Gly 5 10 15 Phe Ser Asn Phe Gly Glu His Gln Leu Thr Leu Phe Ala Val Phe Leu 20 25 30 Ala Leu Tyr Ile Pro Thr Leu Ala Gly Asn Val Ile Ile Val Thr Ile 35 40 45 Ile His Ile Asp His His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Val Leu Ser Thr Ser Glu Thr Phe Tyr Ser Leu Val Ile Ile Pro Arg 65 70 75 80 Met Leu Ser Ser Leu Ile Gly Leu Ser Gln Ser Ile Ser Leu Val Gly 85 90 95 Cys Gly Thr Gln Leu Phe Phe Phe Leu Gly Phe Ala Ile Thr Asn Cys 100 105 110 Leu Leu Leu Ala Val Met Gly Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Ser Ile Ile Met Asn Trp Arg Val Cys Thr Ile Leu 130 135 140 Ala Ser Ser Val Cys Ala Ser Gly Phe Leu Leu Ser Leu Val Gln Ala 145 150 155 160 Val Ala Ile Phe Arg Leu Pro Phe Cys Asn Ser Leu Ile Glu His Phe 165 170 175 Phe Cys Asp Val Arg Pro Val Leu Asp Leu Ala Cys Ala Thr Pro Val 180 185 190 Ile Asn Asp Ile Leu Thr Leu Val Ile Ser Leu Leu Ala Ile Thr Ala 195 200 205

Page 2096

Pro Ala 210 Thr Phe Leu Phe Val 215 069269_0225_SL.TXT Ser Tyr Ile Leu Ile Ile 220 Ser Thr Ile Leu Lys Ile Ala Ser Ala Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys 225 230 235 240 Ala Ser His Leu Thr Val Val Ile Ile His Tyr Gly Cys Ala Ser Ile 245 250 255 Ala Tyr Phe Lys Pro Lys Ser Glu Asn Thr Arg Asp Gln Asp Gln Leu 260 265 270 Ile Ser Val Thr Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Val Val 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Gln Asp Ala Leu Arg Arg Val Val 290 295 300 Gly Arg Lys Ser Leu Pro 305 310

<210> 1871 <211> 933 <212> DNA <213> Canis familiaris <400> 1871

atgccaaact ccactgctgt gactgagttc ctcctggaag ggttctccag ctttgggtgg 60 cagcaccggc ttgtcttctt tgctgtcttt ctaactctgt acctactgac tctctgcggc 120 aatgtcatca tcgtgactat tattcatctg gaccgtcacc tccacacccc catgtacttc 180 ttcctgagca tgctgtccct ctctgagacc tgctacaccg tggccatcat tccccgtatg 240 ctttctggcc tcctgaatcc ccaccagccc attgctgtcc aaggctgtgc cactcagctc 300 ttcttctatc tcacctttgg catcaacaac tgcttcctgc tcacagccat gggctatgac 360 cgctacgtgg ccatctgcaa ccccctgcgg tactcagtca tcatgagtaa agagacttgt 420 gtccagttgg catatggatc actgggaatt ggcttgagca tggccatcat ccaggtaaca 480 tctgtgtttg gcctgccctt ctgtgatgca tttgtcatct ctcacttctt ctgtgacgtg 540

Page 2097

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agacccctgc tgaagctggc ctgcatggac accactgtca acgagatcat caactttgtt 600 gtcagtgtct gtgtcctggt tctacccatg ggcctggtct tcatctccta tgttctcatc 660 atctccacca tccttaagat cacttcagct gagggccgga agaaggcttt tgccacctgc 720 gcctcccacc tcaccgtggt catcatccac tatggctgcg cttccatcat ctacctcaag 780 cccaagtccc agagttctct ggggcaggac agactcctct ctgtgaccta cacagtcatc 840 acccccttgc tgaaccccgt tgtgtacagc ctgcggaaca aagaggtcaa ggatgctctg 900 cacagagctg tggggcggaa tctttcctct taa 933

<210> 1872 <211> 310 <212> PRT <213> Canis familiaris <400> 1872

Met Pro Asn Ser Thr Ala Val Thr Glu Phe Leu Leu Glu Gly Phe Ser 1 5 10 15 Ser Phe Gly Trp Gln His Arg Leu Val Phe Phe Ala Val Phe Leu Thr 20 25 30 Leu Tyr Leu Leu Thr Leu Cys Gly Asn Val Ile Ile Val Thr Ile Ile 35 40 45 His Leu Asp Arg His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Met 50 55 60 Leu Ser Leu Ser Glu Thr Cys Tyr Thr Val Ala Ile Ile Pro Arg Met 65 70 75 80 Leu Ser Gly Leu Leu Asn Pro His Gln Pro Ile Ala Val Gln Gly Cys 85 90 95 Ala Thr Gln Leu Phe Phe Tyr Leu Thr Phe Gly Ile Asn Asn Cys Phe 100 105 110 Leu Leu Thr Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125

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Leu Arg 130 Tyr Ser Val Ile Met Ser Lys Glu Thr Cys Val Gln Leu Ala 135 140 Tyr Gly Ser Leu Gly Ile Gly Leu Ser Met Ala Ile Ile Gln Val Thr 145 150 155 160 Ser Val Phe Gly Leu Pro Phe Cys Asp Ala Phe Val Ile Ser His Phe 165 170 175 Phe Cys Asp Val Arg Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Thr 180 185 190 Val Asn Glu Ile Ile Asn Phe Val Val Ser Val Cys Val Leu Val Leu 195 200 205 Pro Met Gly Leu Val Phe Ile Ser Tyr Val Leu Ile Ile Ser Thr Ile 210 215 220 Leu Lys Ile Thr Ser Ala Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys 225 230 235 240 Ala Ser His Leu Thr Val Val Ile Ile His Tyr Gly Cys Ala Ser Ile 245 250 255 Ile Tyr Leu Lys Pro Lys Ser Gln Ser Ser Leu Gly Gln Asp Arg Leu 260 265 270 Leu Ser Val Thr Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Val Val 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Leu His Arg Ala Val 290 295 300 Gly Arg Asn Leu Ser Ser

305 310 <210> 1873 <211> 933 <212> DNA

Page 2099

069269_0225_SL.TXT <213> Canis familiaris <400> 1873 atgaagagcg agaaccacac cgtggtgggt gagttcgttc tccagggctt ttccagcttt 60 agagaacacc agatcatcct ctttgttata tttcttacct tgtacctttt tactctggct 120 ggcaatgtcg tcatcgtgac ggttattggc tctgcccgtc acctccacac ccccatgtac 180 ttcttcctta gcgtcctctc cgtgtccgag accgtgtaca cgctggtcat tgtaccgcgg 240 atgctctgca gccttatggg tctcagccga cgcatctcac gggcgggctg tgccacccag 300 atgttcttct tcatcacctt ggccatcaac aactgcttcc tgctcacggc catgggctac 360 gaccgctacg tggccatctg caaccccctg cggtacacgg tcgtcatgag caagagggtg 420 tgtgccctgc tcgtatgggg cgctttcagc attgggctgc tggtggccat aattcagatt 480 tcctccgtgt tcaggctgcc cttttgtgac agagaagtgg cccattattt ctgtgacatc 540 cgcccagtta tggaactctc ctgtgcagac accactctac acgacatcat taactttatc 600 atcagctccc tggttatcgt ggtgcccatg gggctggtct tcgtctccta cgtcctcatc 660 atctccacca tcctcaagat cagctctgcc cagggccgga agaaggcctt tgccacctgc 720 gcctcccacc tcatcgtggt catcgtccac tacggctgcg cctccatcgc ctacctcaag 780 cccaagtcgg agaacaccag ggatgaggac cagctgatct cagtgaccta cacggtcatc 840 accccgctgc tgaacccggt ggtgtacacc ctgaggaaca aggaggtcaa ggatgctctg 900 caccgtgcta tcagcaaaaa tcctcatgcc tag 933 <210> 1874 <211> 310 <212> PRT <213> Canis familiaris <400> 1874

Met 1 Lys Ser Glu Asn 5 His Thr Val Val Gly Glu Phe Val Leu Gln Gly 10 15 Phe Ser Ser Phe Arg Glu His Gln Ile Ile Leu Phe Val Ile Phe Leu 20 25 30 Thr Leu Tyr Leu Phe Thr Leu Ala Gly Asn Val Val Ile Val Thr Val 35 40 45

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Ile Gly 50 Ser Ala Arg His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 55 60 Val Leu Ser Val Ser Glu Thr Val Tyr Thr Leu Val Ile Val Pro Arg 65 70 75 80 Met Leu Cys Ser Leu Met Gly Leu Ser Arg Arg Ile Ser Arg Ala Gly 85 90 95 Cys Ala Thr Gln Met Phe Phe Phe Ile Thr Leu Ala Ile Asn Asn Cys 100 105 110 Phe Leu Leu Thr Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Thr Val Val Met Ser Lys Arg Val Cys Ala Leu Leu 130 135 140 Val Trp Gly Ala Phe Ser Ile Gly Leu Leu Val Ala Ile Ile Gln Ile 145 150 155 160 Ser Ser Val Phe Arg Leu Pro Phe Cys Asp Arg Glu Val Ala His Tyr 165 170 175 Phe Cys Asp Ile Arg Pro Val Met Glu Leu Ser Cys Ala Asp Thr Thr 180 185 190 Leu His Asp Ile Ile Asn Phe Ile Ile Ser Ser Leu Val Ile Val Val 195 200 205 Pro Met Gly Leu Val Phe Val Ser Tyr Val Leu Ile Ile Ser Thr Ile 210 215 220 Leu Lys Ile Ser Ser Ala Gln Gly Arg Lys Lys Ala Phe Ala Thr Cys 225 230 235 240 Ala Ser His Leu Ile Val Val Ile Val His Tyr Gly Cys Ala Ser Ile 245 250 255

Page 2101

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Ala Tyr Leu Lys 260 Pro Lys Ser Glu Asn Thr Arg Asp Glu Asp Gln Leu 265 270 Ile Ser Val Thr Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Val Val 275 280 285 Tyr Thr Leu Arg Asn Lys Glu Val Lys Asp Ala Leu His Arg Ala Ile 290 295 300 Ser Lys Asn Pro His Ala

305 310 <210> 1875 <211> 936 <212> DNA <213> Canis familiaris <400> 1875 atgaagagcc agctgaacag gaattcctca ggagtgactg agttcattct gctgggcttc agaacccctc cgaagctgca gatcttcttg ttcttggtgt tcttgctggc ctacgtggtc actgtggtgg gaaataccag catgataatt gtcatcagga tggactcgag gcttcataca cctatgtatt tcttccttag aaacttatcc tatttagatc tctgctactc tacagtcatt gctcccaaaa ctttagccaa cttcctatct catgaaaaga agatttccta caatggctgt gcagcccaat ttttcttctt tgctctgttt gtcacaactg aaggctttct tctggccgtg atggcatatg atcgcttctc agccatttgc tcgccattcc tctatcctgt ccgtatgtct caacaggttt gtgttcattt agtaattggc tcctacatct gtggaggcat caactccatg gtccagacag gattcacctt cagcttgcgt ttctgtggag aaaaccgact ggaccacttc ttctgtgatg tcccagccct gatcaagatc tcatgtgttg acacgtctgt gaacgagatg gtgctattca ttctctcctc cctcatcatt gtcaccacca caagtgtcat cctggtttcc tatgcttaca tactctccac tgtcctgaag atcccctcca cctatggtag gggtaagacc ttctccacct gtggctccca catggccacg gtgagtttgt tctatgggac tgtgttcttc atgtacgccc agcctggggc catctcctcc ccagggcaaa acaaggtcat agctgtgctc

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936

069269_0225_SL.TXT tacacactca tcatcccaat gctaaaccct ctgatataca gtctaagaaa cagagacgtg aaagatgctg tgagaagaat gctgtacagg aagtga <210> 1876 <211> 311 <212> PRT <213> Canis familiaris <400> 1876

Met 1 Lys Ser Gln Leu Asn Arg Asn Ser Ser Gly Val Thr Glu Phe Ile 5 10 15 Leu Leu Gly Phe Arg Thr Pro Pro Lys Leu Gln Ile Phe Leu Phe Leu 20 25 30 Val Phe Leu Leu Ala Tyr Val Val Thr Val Val Gly Asn Thr Ser Met 35 40 45 Ile Ile Val Ile Arg Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Arg Asn Leu Ser Tyr Leu Asp Leu Cys Tyr Ser Thr Val Ile 65 70 75 80 Ala Pro Lys Thr Leu Ala Asn Phe Leu Ser His Glu Lys Lys Ile Ser 85 90 95 Tyr Asn Gly Cys Ala Ala Gln Phe Phe Phe Phe Ala Leu Phe Val Thr 100 105 110 Thr Glu Gly Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Ser Ala 115 120 125 Ile Cys Ser Pro Phe Leu Tyr Pro Val Arg Met Ser Gln Gln Val Cys 130 135 140 Val His Leu Val Ile Gly Ser Tyr Ile Cys Gly Gly Ile Asn Ser Met 145 150 155 160 Val Gln Thr Gly Phe Thr Phe Ser Leu Arg Phe Cys Gly Glu Asn Arg

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165 170 175

Leu Asp His Phe Phe Cys Asp Val Pro Ala Leu Ile Lys Ile Ser Cys 180 185 190 Val Asp Thr Ser Val Asn Glu Met Val Leu Phe Ile Leu Ser Ser Leu 195 200 205 Ile Ile Val Thr Thr Thr Ser Val Ile Leu Val Ser Tyr Ala Tyr Ile 210 215 220 Leu Ser Thr Val Leu Lys Ile Pro Ser Thr Tyr Gly Arg Gly Lys Thr 225 230 235 240 Phe Ser Thr Cys Gly Ser His Met Ala Thr Val Ser Leu Phe Tyr Gly 245 250 255 Thr Val Phe Phe Met Tyr Ala Gln Pro Gly Ala Ile Ser Ser Pro Gly 260 265 270 Gln Asn Lys Val Ile Ala Val Leu Tyr Thr Leu Ile Ile Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Arg Asp Val Lys Asp Ala Val 290 295 300 Arg Arg Met Leu Tyr Arg Lys

305 310 <210> 1877 <211> 861 <212> DNA <213> Canis familiaris <400> 1877 atgatgggaa accagacatc agtgatagaa ttcattcttc ttggactgac gaatgacact gagcttcaag ctgtgctttt cctttttctg ctgctaactt atgtcttaag catcatggga aacttgacca tcatcattct gacccttttg gattatcgcc ttcagactcc tatgtatttc tttctccgga atttttctgt tttggaaata tcttttactt ctgtctttgt tcccaaaatg

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ctagtcaata ttgcaactgg agacaagact atctccttcg ctggatgttt cactcagtat 300 ttttttgcca tccttctggg ggcaactgga ttttatcttt tagctgccat gtcctatgat 360 tgctatgttg ccatttgtaa acccctacat tatacaactg taatgagcag caaactgcat 420 tcaacttgtt ctgtgttcct ggttctctgg ttttttggtt actgctgcat ctgtcctgtt 480 cagacacaca gttcattgga aatgatggag tttatctttg cagcagttac cgtcatcttc 540 accttggtgc tagtgattct ttcctacacg tacataatca ggacaattct gagaatccct 600 tctgttcaac aaaggaaaaa agccttttct acatgctcct gtcacattat tgtggtctca 660 ctttcttatg gaagttgtat ctttatgtac ataaatcctt ctcttaagga tgcagaaact 720 tttaataaga gagtggctgt tttaaatacc tcagttgccc ctctgttgaa ccctttcatc 780 tataccctaa ggaaaaagca agtgaaaata gccttcaaag acatggtcag caagataatg 840 atgttttcag gaaaatgaaa ^g 861

<210> 1878 <211> 285 <212> PRT <213> Canis familiaris

<400> 1878 Gln Thr 5 Ser Val Ile Glu Phe Ile Leu Leu Gly Leu Met Met 1 Gly Asn 10 15 Thr Asn Asp Thr Glu Leu Gln Ala Val Leu Phe Leu Phe Leu Leu Leu 20 25 30 Thr Tyr Val Leu Ser Ile Met Gly Asn Leu Thr Ile Ile Ile Leu Thr 35 40 45 Leu Leu Asp Tyr Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn 50 55 60 Phe Ser Val Leu Glu Ile Ser Phe Thr Ser Val Phe Val Pro Lys Met 65 70 75 80 Leu Val Asn Ile Ala Thr Gly Asp Lys Thr Ile Ser Phe Ala Gly Cys 85 90 95

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Phe Thr Gln Tyr Phe Phe Ala Ile Leu Leu Gly Ala Thr Gly Phe Tyr 100 105 110 Leu Leu Ala Ala Met Ser Tyr Asp Cys Tyr Val Ala Ile Cys Lys Pro 115 120 125 Leu His Tyr Thr Thr Val Met Ser Ser Lys Leu His Ser Thr Cys Ser 130 135 140 Val Phe Leu Val Leu Trp Phe Phe Gly Tyr Cys Cys Ile Cys Pro Val 145 150 155 160 Gln Thr His Ser Ser Leu Glu Met Met Glu Phe Ile Phe Ala Ala Val 165 170 175 Thr Val Ile Phe Thr Leu Val Leu Val Ile Leu Ser Tyr Thr Tyr Ile 180 185 190 Ile Arg Thr Ile Leu Arg Ile Pro Ser Val Gln Gln Arg Lys Lys Ala 195 200 205 Phe Ser Thr Cys Ser Cys His Ile Ile Val Val Ser Leu Ser Tyr Gly 210 215 220 Ser Cys Ile Phe Met Tyr Ile Asn Pro Ser Leu Lys Asp Ala Glu Thr 225 230 235 240 Phe Asn Lys Arg Val Ala Val Leu Asn Thr Ser Val Ala Pro Leu Leu 245 250 255 Asn Pro Phe Ile Tyr Thr Leu Arg Lys Lys Gln Val Lys Ile Ala Phe 260 265 270 Lys Asp Met Val Ser Lys Ile Met Met Phe Ser Gly Lys 275 280 285

<210> 1879 <211> 969

Page 2106

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 1879

atggaaaacc gtacaactgt gacagtattt atcttagcag gattgatgga ggaccccaaa 60 ctgaagattg tgctatttgt cttcctgctc ctcacttact tgctaagcat ctcaggcaac 120 ttagttatta ttaccctcac tttgctggac tcacatctca agacccctat gtatttcttt 180 cttcgaaata tttctttctt agaaatttct tatatgacag tctgcatccc caaattgctt 240 gtaagcatgg caactggtga caaaaccatt tcttataact gtcgtgcaac tcagttgttt 300 gccttccttc ttggagcatc tgaatgttac ctcctggctg tcatgtccta cgatcgttat 360 gtcgccatct gcaggcccct gcattacaca accattatga gcagcaaaat ctgtatccag 420 ctagtcctta gctcttggat cactggtttc ctcatcatct ttccaggact cattttaggc 480 ttaagcctgg acttctgtga ttccaatgtc attgatcatt tctactgtga cactgctccc 540 ctcctgcaga tctcctgcac agacagacac gtgttggaaa tgatgagttt catcttagct 600 ttggtgactc tgctggtcac tttggcatta gtaaatctat catacacata tattgccctg 660 acaattttaa aaattccttc tgtcaaccag agaaaaaaga aaaaagcttt ctccacctgt 720 tcttctcaca tgattgtcat ctccctctca tatggcagct gcatctttat gtaccttaaa 780 ccctcagtca aacagaggat atccttgatg aagggagtgg cagttctcaa tacttctgtt 840 gctccacttt tgaatccctt tatttatact ctaaggaaac agcaagtgaa gcaagcattt 900 tatttttctg ttccattgta agcattctca atttttaaaa acattttaaa aaatattttt 960

cttatttat 969 <210> 1880 <211> 306 <212> PRT <213> Canis familiaris <400> 1880

Met Glu Asn Arg Thr Thr Val Thr Val Phe Ile Leu Ala Gly Leu Met 1 5 10 15

Glu Asp Pro Lys Leu Lys Ile Val Leu Phe Val Phe Leu Leu Leu Thr 20 25 30

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Tyr Leu Leu 35 Ser Ile Ser Gly Asn Leu Val Ile Ile Thr Leu Thr Leu 40 45 Leu Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Ile 50 55 60 Ser Phe Leu Glu Ile Ser Tyr Met Thr Val Cys Ile Pro Lys Leu Leu 65 70 75 80 Val Ser Met Ala Thr Gly Asp Lys Thr Ile Ser Tyr Asn Cys Arg Ala 85 90 95 Thr Gln Leu Phe Ala Phe Leu Leu Gly Ala Ser Glu Cys Tyr Leu Leu 100 105 110 Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu His 115 120 125 Tyr Thr Thr Ile Met Ser Ser Lys Ile Cys Ile Gln Leu Val Leu Ser 130 135 140 Ser Trp Ile Thr Gly Phe Leu Ile Ile Phe Pro Gly Leu Ile Leu Gly 145 150 155 160 Leu Ser Leu Asp Phe Cys Asp Ser Asn Val Ile Asp His Phe Tyr Cys 165 170 175 Asp Thr Ala Pro Leu Leu Gln Ile Ser Cys Thr Asp Arg His Val Leu 180 185 190 Glu Met Met Ser Phe Ile Leu Ala Leu Val Thr Leu Leu Val Thr Leu 195 200 205 Ala Leu Val Asn Leu Ser Tyr Thr Tyr Ile Ala Leu Thr Ile Leu Lys 210 215 220 Ile Pro Ser Val Asn Gln Arg Lys Lys Lys Lys Ala Phe Ser Thr Cys 225 230 235 240

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Ser Ser His Met Ile Val Ile Ser Leu Ser Tyr Gly Ser Cys Ile Phe 245 250 255 Met Tyr Leu Lys Pro Ser Val Lys Gln Arg Ile Ser Leu Met Lys Gly 260 265 270 Val Ala Val Leu Asn Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile 275 280 285 Tyr Thr Leu Arg Lys Gln Gln Val Lys Gln Ala Phe Tyr Phe Ser Val 290 295 300

Pro Leu 305 <210> 1881 <211> 462 <212> DNA <213> Canis familiaris <400> 1881 attgagctga tggggtactt aaccattatc ctcctcactc tggtggatcc tcacctcaag 60 atgccaatgt atttctttct ctgtaatttc tcatttttag aaatcatatt cacaacggta 120 tgtattccca gatatttgaa aaccgtagtg actaaagaac aaaacatttc taataataac 180 tctgtggctc aattattttt tattctttta ctgggagttg cagagtttta ccttctggct 240 gctatgtcct atgaccgcta tgttgccatc tgtaaaccct tgcattaccc aatcattatg 300 aacagcagag tgtgctattg gcttgtactt tcttcctggc tgactggatt cctaatcatc 360 tttcccccat tgctcatggg actcaagctg gatttctgtg cttccaaaat gactttatgt 420 atgaaacttc ccccatcctg cagatatcct gcacagacac ac 462 <210> 1882 <211> 154 <212> PRT <213> Canis familiaris <400> 1882

Ile Glu Leu Met Gly Tyr Leu Thr Ile Ile Leu Leu Thr Leu Val Asp 1 5 10 15

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Pro His Leu Lys 20 Met Pro Leu Glu Ile 35 Ile Phe Thr Val Val 50 Thr Lys Glu Gln Leu 65 Phe Phe Ile Leu Leu 70 Ala Met Ser Tyr Asp 85 Arg Pro Ile Ile Met 100 Asn Ser Trp Leu Thr 115 Gly Phe Leu Lys Leu 130 Asp Phe Cys Ala Pro 145 Ser Cys Arg Tyr Pro 150

Met Tyr Phe 25 Phe Leu Thr Val 40 Cys Ile Pro Asn 55 Ile Ser Asn Asn Leu Gly Val Ala Glu 75 Tyr Val Ala Ile 90 Cys Arg Val Cys 105 Tyr Trp Ile Ile 120 Phe Pro Pro Ser 135 Lys Met Thr Leu Ala Gln Thr His

Cys Asn Phe 30 Ser Phe Arg Tyr 45 Leu Lys Thr Asn 60 Ser Val Ala Gln Phe Tyr Leu Leu Ala 80 Lys Pro Leu His 95 Tyr Leu Val Leu 110 Ser Ser Leu Leu 125 Met Gly Leu Cys 140 Met Lys Leu Pro

<210> 1883 <211> 930 <212> DNA <213> Canis familiaris <400> 1883 atggctgcag aaaatcactc ccagatctcc agctcccact gggaacctgg gcatgttcac tacttcctca gcaacctgtc aacagtgacc gagttcattc tctcctcctc ttccttggga actgatttgt ctgaatgctc acttgtggat ctctgctact tcaggggctt gacaagtcag tctacttggt caccgtgatg agcttcacac ccccatgtac cctctgccat tacccctaaa

120

180

240

Page 2110

069269_0225_SL.TXT atgttggtga actttgtgtc agagaagaac atcatctcct attcagggtg catgtcacag ctctacttct tcctactgtt tgtcattgct gagtgttaca tgctgacagt gatggcctat gaccgctatg tcgccatctg cagccctttg ctctacaatg tcatcatgag tcatcaagtc tgctccctgc tggtggctgt ggtctatgcc atggggctca ttggctcaac aatagagact ggcctcatgt taaaactgtc ctattgtgag ctcctcatca gccattactt ctgtgacatc ctccctctca tgaagctctc ctgctctagc acctacgata ttgagatgac agtcttcttt ttggccggat ttaacatcat actcaccagt ttaacagtcc ttgtttccta tgccttcatc ctctccagca tcctccgcat cagcaccaca gagggcaggt ccaaagcctt cagcacctgc agctcccacc ttgctgctgt ggggatgttc tacgggtcta ctgcgttcat gtacctgaaa ccctccacgg ccagttccct ggcccaggag aacatagcct ctgtgttcta cactacagtg attcccatgc tgaaccccct gatctacagc ttgaggaata aggaggtaaa ggctgctttg cagaaaacac tgaggagaaa aatgttctga <210> 1884 <211> 309 <212> PRT <213> Canis familiaris

300

360

420

480

540

600

660

720

780

840

900

930

<400> 1884 Asn His 5 Ser Thr Val Thr Glu Phe Ile Leu Arg Gly Met Ala 1 Ala Glu 10 15 Leu Thr Ser Gln Pro Asp Leu Gln Leu Pro Leu Leu Leu Leu Phe Leu 20 25 30 Gly Ile Tyr Leu Val Thr Val Met Gly Asn Leu Gly Met Phe Thr Leu 35 40 45 Ile Cys Leu Asn Ala Gln Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Asn Leu Ser Leu Val Asp Leu Cys Tyr Ser Ser Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Val Ser Glu Lys Asn Ile Ile Ser Tyr Ser Gly Page 2111

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85 90 95 Cys Met Ser Gln Leu Tyr Phe Phe Leu Leu Phe Val Ile Ala Glu Cys 100 105 110 Tyr Met Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr Asn Val Ile Met Ser His Gln Val Cys Ser Leu Leu 130 135 140 Val Ala Val Val Tyr Ala Met Gly Leu Ile Gly Ser Thr Ile Glu Thr 145 150 155 160 Gly Leu Met Leu Lys Leu Ser Tyr Cys Glu Leu Leu Ile Ser His Tyr 165 170 175 Phe Cys Asp Ile Leu Pro Leu Met Lys Leu Ser Cys Ser Ser Thr Tyr 180 185 190 Asp Ile Glu Met Thr Val Phe Phe Leu Ala Gly Phe Asn Ile Ile Leu 195 200 205 Thr Ser Leu Thr Val Leu Val Ser Tyr Ala Phe Ile Leu Ser Ser Ile 210 215 220 Leu Arg Ile Ser Thr Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Ala Ala Val Gly Met Phe Tyr Gly Ser Thr Ala Phe 245 250 255 Met Tyr Leu Lys Pro Ser Thr Ala Ser Ser Leu Ala Gln Glu Asn Ile 260 265 270 Ala Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Leu Gln Lys Thr Leu

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290 295 300

Arg Arg Lys Met Phe 305 <210> 1885 <211> 897 <212> DNA <213> Canis familiaris <400> 1885

cctgtgctcc agcaacccct cttcttcctg tttctgatga tctacatcgt caccatggtg 60 ggcaaccttg gcttgatcat cctcatcggt ctcaattctc acctccacat ccccatgtac 120 tatttcctct tcaatctatc cttcattgat ctctgttact cttctgtttt cacccccaag 180 atgctgatga actttgtatc aaaggacaat atcatctcct atgttgggtg catgactcaa 240 ctgttcttct ttctcttttt tgtcatctca gaatgctaca tgttgacctc gatggcctat 300 gaccgctacg tggccatctg taatccattg ctgtataagg tcaccatgtc ccatcaggtc 360 tgttccttgc taactgttgc tgcatatatg atgggatttg ccggagcctc tgcccacacg 420 gggtgcatgc ttagactaac gttctgcaat gtcaatatca tcaaccatta cctgtgtgac 480 atccttcctc tcctccaact ctcttgcatc agcacctata tcagtgagat agtagttctg 540 atagtcatgg gaattaatat cacagtaccc agttttacca ttctgatttc ttatgtcttc 600 attctcacta acatttttca catcaaaact gctcaaggaa ggtcaaaagc cttcagtacc 660 tgtagctttc acatcattgc tctttgcctt tttttgctct ttgccttttt tcttggatca 720 gcagcattca tgtatcttaa atattcttct tctggatcta tggacctggg aaaaatttct 780 tcagtgtttt atactaatgt gatacccatg ctcaatcccc tgatctacag tttgtggaac 840 aaggatatca aagttacact gcagaaaacc ttgcttaaaa tccagagtag aaacatg 897

<210> 1886 <211> 299 <212> PRT <213> Canis familiaris <400> 1886

Pro Val Leu Gln Gln Pro Leu Phe Phe Leu Phe Leu Met Ile Tyr Ile 1 5 10 15

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Val Thr Met Val 20 Gly Asn Leu Gly Leu Ile Ile Leu Ile Gly Leu Asn 25 30 Ser His Leu His Ile Pro Met Tyr Tyr Phe Leu Phe Asn Leu Ser Phe 35 40 45 Ile Asp Leu Cys Tyr Ser Ser Val Phe Thr Pro Lys Met Leu Met Asn 50 55 60 Phe Val Ser Lys Asp Asn Ile Ile Ser Tyr Val Gly Cys Met Thr Gln 65 70 75 80 Leu Phe Phe Phe Leu Phe Phe Val Ile Ser Glu Cys Tyr Met Leu Thr 85 90 95 Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Leu Tyr 100 105 110 Lys Val Thr Met Ser His Gln Val Cys Ser Leu Leu Thr Val Ala Ala 115 120 125 Tyr Met Met Gly Phe Ala Gly Ala Ser Ala His Thr Gly Cys Met Leu 130 135 140 Arg Leu Thr Phe Cys Asn Val Asn Ile Ile Asn His Tyr Leu Cys Asp 145 150 155 160 Ile Leu Pro Leu Leu Gln Leu Ser Cys Ile Ser Thr Tyr Ile Ser Glu 165 170 175 Ile Val Val Leu Ile Val Met Gly Ile Asn Ile Thr Val Pro Ser Phe 180 185 190 Thr Ile Leu Ile Ser Tyr Val Phe Ile Leu Thr Asn Ile Phe His Ile 195 200 205 Lys Thr Ala Gln Gly Arg Ser Lys Ala Phe Ser Thr Cys Ser Phe His 210 215 220

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Ile 225 Ile Ala Leu Cys Leu Phe Leu Leu 230 Phe Ala Phe Phe Leu Gly Ser 235 240 Ala Ala Phe Met Tyr Leu Lys Tyr Ser Ser Ser Gly Ser Met Asp Leu 245 250 255 Gly Lys Ile Ser Ser Val Phe Tyr Thr Asn Val Ile Pro Met Leu Asn 260 265 270 Pro Leu Ile Tyr Ser Leu Trp Asn Lys Asp Ile Lys Val Thr Leu Gln 275 280 285 Lys Thr Leu Leu Lys Ile Gln Ser Arg Asn Met

290 295 <210> 1887 <211> 933 <212> DNA <213> Canis familiaris <400> 1887

atgcctcctg gaaatgcttc tcttgtgact gaattcattc tggtggggct cacagactta 60 ccatatctcc agctccccct gttctgcctg tttctactca tgtatgtggt cactgtgctg 120 ggaaacttat gcttggtcac tcttatcagg ctgaattctc acctccacac ccccatgtac 180 tttttcctct tcaatttgtc cttcatagac ctctgttatt cttctgtgtt tacacccaaa 240 atgttgatta acttcacatc caagaagaat attatctcct acatggggtg catgacccag 300 ctttactttt tctgtttttt tgttgtttct gaatgctatg tgctgacatc catggcctat 360 gatcgctatg tggccatctg taacccactt ttgtataatg ttgccatgtc ccctaatgtg 420 tgttccctcc ttatgcttgg ttcatatttg atggcattct caggtgccat ggcccacaca 480 ggatgcatgc tgagactgat cttctgtgat gcaaacacca tcaaccatta tttgtgtgac 540 attctccctc tgctccagct ctcctgcacc agcacgtatg tgaatgagct ggtggttttc 600 attgtggtgg gcatcaacat cattgtgccc agtgtcaccg tctttgtgtc ttatggtttc 660 atcctttcca gcatcctgcg cataagctcc actgagggca ggtccaaggc attcagtgcc 720

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069269_0225_SL.TXT tgtagttccc acataattgc tgtttctctc ttctttgggt caggtgcatt tatgtatctt aaaccatcat ccactgagtc tatggatgag ggaaaaatct cttctgtctt ttataccaat gtggttccca tgatgaaccc tttaatctat agcttgagga acaaagatgt taaaattgct ttgcaaaaaa ccctcaatag aagaacgttt tga

780

840

900

933 <210> 1888 <211> 310 <212> PRT <213> Canis familiaris <400> 1888

Met Pro Pro Gly Asn Ala Ser Leu Val Thr Glu Phe Ile Leu Val Gly 1 5 10 15 Leu Thr Asp Leu Pro Tyr Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu 20 25 30 Leu Met Tyr Val Val Thr Val Leu Gly Asn Leu Cys Leu Val Thr Leu 35 40 45 Ile Arg Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Phe Thr Pro Lys 65 70 75 80 Met Leu Ile Asn Phe Thr Ser Lys Lys Asn Ile Ile Ser Tyr Met Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Cys Phe Phe Val Val Ser Glu Cys 100 105 110 Tyr Val Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Ala Met Ser Pro Asn Val Cys Ser Leu Leu 130 135 140 Met Leu Gly Ser Tyr Leu Met Ala Phe Ser Gly Ala Met Ala His Thr

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145 150 155 160 Gly Cys Met Leu Arg Leu Ile Phe Cys Asp Ala Asn Thr Ile Asn His 165 170 175 Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr 180 185 190 Tyr Val Asn Glu Leu Val Val Phe Ile Val Val Gly Ile Asn Ile Ile 195 200 205 Val Pro Ser Val Thr Val Phe Val Ser Tyr Gly Phe Ile Leu Ser Ser 210 215 220 Ile Leu Arg Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Ala 225 230 235 240 Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu Lys Pro Ser Ser Thr Glu Ser Met Asp Glu Gly Lys 260 265 270 Ile Ser Ser Val Phe Tyr Thr Asn Val Val Pro Met Met Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ile Ala Leu Gln Lys Thr 290 295 300 Leu Asn Arg Arg Thr Phe 305 310

<210> 1889 <211> 933 <212> DNA <213> Canis familiaris <400> 1889 atggctccta caaactcctc ttttgtgact gaattcattc tggtggggct cacagactta ccagatctcc agctccccct tttctgcctg tttctactca tgtatatggt caccctgttg

120

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ggaaatttgg gtttgatctt tctgattggg ctgaattcac acctccacac ccccatgtac 180 tttttcctct tcaatttgtc cttcatagac ttctgttatt cctctgtgtt tactcccaaa 240 atgctgatta acttcatatc caaaaagaat attatctcct acaaggggtg catgacccag 300 ctttactttt tctgtttttt tgctatttct gaatgctatg tgctgacatc catggcctat 360 gatcgctatg tggccatctg taacccactt ttgtataatg ttgtcatgtc tcctaatgtg 420 tgtttcagtc ttatgcttgg ttcatatttg atggcattct caggtgccat ggcccacaca 480 ggacgcatgt tgagactgac cttctgtgat gtaaacacca tcaaccacta tttgtgtgac 540 atcctcccac tgctccagct ctcctgcacc agcacgtatg tcaatgaact ggtggtttac 600 attgtagtgg gtatcaatgt gattgtgccc actgtcacca tctttgtctc ttatggcttc 660 atcctctcca gcatcctgcg catcagctcc actgaaggca gatccaaagc tttcagcacc 720 tgcagttccc acataattgc agtttctctc ttttttggtt caggtgcatt tatgtatctt 780 aaaccatctt ctgctgggtc tatggatgaa gggaaaatct cttctgtctt ttacaccact 840 acggttccct tgatgaatcc tttcatttac agcttaagaa acaaagacat taaacttgct 900 ttgagaagaa accagagtag gaaaatgttt tga 933

<210> 1890 <211> 310 <212> PRT <213> Canis familiaris <400> 1890

Met Ala Pro Thr Asn Ser Ser Phe Val Thr Glu Phe Ile Leu Val Gly 1 5 10 15 Leu Thr Asp Leu Pro Asp Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu 20 25 30 Leu Met Tyr Met Val Thr Leu Leu Gly Asn Leu Gly Leu Ile Phe Leu 35 40 45 Ile Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60

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Asn 65 Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Phe Thr Pro Lys 70 75 80 Met Leu Ile Asn Phe Ile Ser Lys Lys Asn Ile Ile Ser Tyr Lys Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Cys Phe Phe Ala Ile Ser Glu Cys 100 105 110 Tyr Val Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Val Met Ser Pro Asn Val Cys Phe Ser Leu 130 135 140 Met Leu Gly Ser Tyr Leu Met Ala Phe Ser Gly Ala Met Ala His Thr 145 150 155 160 Gly Arg Met Leu Arg Leu Thr Phe Cys Asp Val Asn Thr Ile Asn His 165 170 175 Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr 180 185 190 Tyr Val Asn Glu Leu Val Val Tyr Ile Val Val Gly Ile Asn Val Ile 195 200 205 Val Pro Thr Val Thr Ile Phe Val Ser Tyr Gly Phe Ile Leu Ser Ser 210 215 220 Ile Leu Arg Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu Lys Pro Ser Ser Ala Gly Ser Met Asp Glu Gly Lys 260 265 270

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Ile Ser Ser Val Phe Tyr Thr Thr Thr Val Pro Leu Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Leu Ala Leu Arg Arg Asn 290 295 300 Gln Ser Arg Lys Met Phe 305 310

<210> 1891 <211> 933 <212> DNA <213> Canis familiaris <400> 1891

atggctcctg gaaatgcttc tcttgtgact gaattcattc tggtggggct cacagaccta 60 ccagatctcc agctccccct gttctgcttg tttctactca tgtatgtggt cactgtgctg 120 ggaaatttat gcttggtcac tctaatcggg ctgaatccac acctccatac ccccatgtac 180 tttttcctct tcaatttgtc cttcatagac ctcttttatt catctgtgtt tactcccaaa 240 atgctgattc acttcacatc caagaaaaat attatctcct acagggggtg catgacccaa 300 cttttctttt tctgtttttt tggtatttct gaagcttatg tgctgacatc catggcctat 360 gatcgctatg tggccatctg taacccactt ttgtataatg ttgtcatgtc ccctaatgtg 420 tgttccctcc ttatgcttgg ttcatatttg atggcattct caggtgccat ggcccacact 480 ggatgcatgc tgagactgac cttttgtgat gcaaacacca tcaaccacta tttgtgtgac 540 atcctccctc tgctccagct ctcctgcacc agcacgtatg tgaatgagct ggtggttttg 600 attgtggagg gcatcaatgt gattgtgccc actgtcacca tctttgtctc ttatggcttc 660 atcctctcca gcatcctgcg catcagctcc actgaaggca ggtccaaagc cttcagcacc 720 tgtactgccc acataattgc agttactctc ttctttggtt caggtgcatt tatgtatctt 780 aaaccatctt ctgctgggtc tatggatgag gggaaaatct cctctgtctt ttataccaat 840 gtggttccca tgatgaaccc tttcatttac agcttgagaa acaaagacat taaacttgct 900 gtgagaaaaa ctctgagtaa gagagtgttt tga 933

<210> 1892

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069269_0225_SL.TXT <211> 310 <212> PRT <213> Canis familiaris

<400> 1892 Ile Leu Val 15 Gly Met 1 Ala Pro Gly Asn Ala Ser Leu 5 Val Thr 10 Glu Phe Leu Thr Asp Leu Pro Asp Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu 20 25 30 Leu Met Tyr Val Val Thr Val Leu Gly Asn Leu Cys Leu Val Thr Leu 35 40 45 Ile Gly Leu Asn Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Phe Thr Pro Lys 65 70 75 80 Met Leu Ile His Phe Thr Ser Lys Lys Asn Ile Ile Ser Tyr Arg Gly 85 90 95 Cys Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Gly Ile Ser Glu Ala 100 105 110 Tyr Val Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Val Met Ser Pro Asn Val Cys Ser Leu Leu 130 135 140 Met Leu Gly Ser Tyr Leu Met Ala Phe Ser Gly Ala Met Ala His Thr 145 150 155 160 Gly Cys Met Leu Arg Leu Thr Phe Cys Asp Ala Asn Thr Ile Asn His 165 170 175 Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr 180 185 190

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Tyr Val Asn Glu Leu Val Val Leu Ile Val Glu Gly Ile Asn Val Ile 195 200 205 Val Pro Thr Val Thr Ile Phe Val Ser Tyr Gly Phe Ile Leu Ser Ser 210 215 220 Ile Leu Arg Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Thr Ala His Ile Ile Ala Val Thr Leu Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu Lys Pro Ser Ser Ala Gly Ser Met Asp Glu Gly Lys 260 265 270 Ile Ser Ser Val Phe Tyr Thr Asn Val Val Pro Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Leu Ala Val Arg Lys Thr 290 295 300 Leu Ser Lys Arg Val Phe

305 310 <210> 1893 <211> 933 <212> DNA <213> Canis familiaris <400> 1893

atggctcctg gaaatgcttc tcttgtgact gaattcattc tggtggggct cacagaccta 60 ccagatctcc agctccccct gttctgcttg tttctactca tgtatgtggt cactgtgctg 120 ggaaatttat gcttggtcac tctaatcggg ctgaatccac acctccatac ccccatgtac 180 tttttcctct tcaatttgtc cttcatagac ctcttttatt catctgtgtt tactcccaaa 240 atgctgattc acttcacatc caagaaaaat attatctcct acagggggtg catgacccaa 300 cttttctttt tctgtttttt tggtatttct gaagcttatg tgctgacatc catggcctat 360 gatcgctatg tggctatctg taacccactt ttgtataatg ttgtcatgtc ccctaatgtg 420

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tgttccctcc ttatgcttgg ttcatatttg atggcattct caggagccat ggcccacact 480 ggatgcatgc tgagactgac cttctgtgat gcaaacacca tcaaccatta cttgtgtgac 540 atccttcctc tgctccagct ctcctgcacc agcacgtatg tgaatgagct ggtggttttc 600 attgtggtgg gcatcaatgt gattgtgcct agtgtcacca tctttgtgtc ttatggtttc 660 atcctctcta gcatcctgag catcagctcc actgagggca ggtccaaagc cttcagcacc 720 tgcagttccc atgtaattgc agtttctctc ttttttggtt caggtgcatt tatgtatctt 780 aaaccatctt ctgctgggtc tatggatgag gggaaaatct cctctgtctt ttataccaat 840 gcggttccca tgatgaaccc cctcatttac agcttgagaa acaaagacat taaaattgct 900 gtgagaaata ctttgaacag gagacagttt tga 933

<210> 1894 <211> 310 <212> PRT <213> Canis familiaris

<400> 1894 Ala Ser Leu Val Thr Glu Phe Ile Leu Val Gly Met Ala 1 Pro Gly Asn 5 10 15 Leu Thr Asp Leu Pro Asp Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu 20 25 30 Leu Met Tyr Val Val Thr Val Leu Gly Asn Leu Cys Leu Val Thr Leu 35 40 45 Ile Gly Leu Asn Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Phe Thr Pro Lys 65 70 75 80 Met Leu Ile His Phe Thr Ser Lys Lys Asn Ile Ile Ser Tyr Arg Gly 85 90 95 Cys Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Gly Ile Ser Glu Ala 100 105 110

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Tyr Val Leu 115 Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 120 125 Pro Leu Leu Tyr Asn Val Val Met Ser Pro Asn Val Cys Ser Leu Leu 130 135 140 Met Leu Gly Ser Tyr Leu Met Ala Phe Ser Gly Ala Met Ala His Thr 145 150 155 160 Gly Cys Met Leu Arg Leu Thr Phe Cys Asp Ala Asn Thr Ile Asn His 165 170 175 Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr 180 185 190 Tyr Val Asn Glu Leu Val Val Phe Ile Val Val Gly Ile Asn Val Ile 195 200 205 Val Pro Ser Val Thr Ile Phe Val Ser Tyr Gly Phe Ile Leu Ser Ser 210 215 220 Ile Leu Ser Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Val Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu Lys Pro Ser Ser Ala Gly Ser Met Asp Glu Gly Lys 260 265 270 Ile Ser Ser Val Phe Tyr Thr Asn Ala Val Pro Met Met Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Ile Ala Val Arg Asn Thr 290 295 300 Leu Asn Arg Arg Gln Phe

305 310

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069269_0225_SL.TXT <210> 1895 <211> 933 <212> DNA <213> Canis familiaris <400> 1895

atggctccta caaactcctc ttttgtgact gaattcattc tggcaggcct cacagactta 60 ccagatctcc agctccccct gttctgcttg tttctactca tgtatgtggt cactgtgctg 120 ggaaatttgg gcttgatcat tctaatcagg ctgaattcac acctccacac tcccatgtac 180 tttttcctct tcaatttgtc cttcatagac ttctgttatt cttctgtgtt tacacccaaa 240 atgctgattc acttcacatc taagaagaat attatctcct acagggggtg catgacccag 300 ctttactttt tctgtttttt tgttatttct gaatgctatg tgctgacatc catggcctat 360 gatcgctatg tggccatctg taacccactt ttgtataatg ttgccatgtc ccctaatgtg 420 tgttccctcc ttatgcttgg ttcatatttg atggcattct caggtgccat ggcccacact 480 ggatgcatgc tgagactgac cttttgtgat gcaaacacca tcaaccatta cttgtgtgac 540 atcctccctc tgctccagct ctcctgcacc agcacgtatg tgaatgagct ggtggttttc 600 attgtggtgg gcgtcaacat cattgtgccc actgtcacca tctttgtgtc ttatggtttc 660 atcctctcca gcatcctgcg catcagctcc actgaaggca gatccaaagc tttcagcacc 720 tgcagttccc acataattgc agtttctctc ttttttggtt caggtgcatt tatgtatctt 780 aaaccatctt ctgctaggtc tatggatgag gggaaaatct cctctgtctt ttataccaat 840 gtggttccct tgatgaaccc tttcatttat agcttgagaa acaaagtcat taaacttgct 900 ctgagaaaaa tccagagtag gagaatgttt tga 933

<210> 1896 <211> 310 <212> PRT <213> Canis familiaris <400> 1896

Met Ala Pro Thr Asn Ser Ser Phe Val Thr Glu Phe Ile Leu Ala Gly

1 5 10 15

Leu Thr Asp Leu Pro Asp Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu

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069269_0225_SL.TXT 25 30

Leu Met Tyr 35 Val Val Thr Val Leu Gly Asn Leu Gly Leu Ile Ile Leu 40 45 Ile Arg Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Phe Thr Pro Lys 65 70 75 80 Met Leu Ile His Phe Thr Ser Lys Lys Asn Ile Ile Ser Tyr Arg Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Cys Phe Phe Val Ile Ser Glu Cys 100 105 110 Tyr Val Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Ala Met Ser Pro Asn Val Cys Ser Leu Leu 130 135 140 Met Leu Gly Ser Tyr Leu Met Ala Phe Ser Gly Ala Met Ala His Thr 145 150 155 160 Gly Cys Met Leu Arg Leu Thr Phe Cys Asp Ala Asn Thr Ile Asn His 165 170 175 Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr 180 185 190 Tyr Val Asn Glu Leu Val Val Phe Ile Val Val Gly Val Asn Ile Ile 195 200 205 Val Pro Thr Val Thr Ile Phe Val Ser Tyr Gly Phe Ile Leu Ser Ser 210 215 220 Ile Leu Arg Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr

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225 230 235 240 Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu Lys Pro Ser Ser Ala Arg Ser Met Asp Glu Gly Lys 260 265 270 Ile Ser Ser Val Phe Tyr Thr Asn Val Val Pro Leu Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Val Ile Lys Leu Ala Leu Arg Lys Ile 290 295 300 Gln Ser Arg Arg Met Phe 305 310

<210> 1897 <211> 933 <212> DNA <213> Canis familiaris <400> 1897

atggctctca gaaatgcttc ttttgtgact gaattcattc tggcaggcct cacagaccta 60 ccagatctcc agctccccct tttctgcttg tttctactca tgtatgtggt cactgtgttg 120 ggaaatttgg gcttgatcat tctcatcagg ctgaattcac acctccacac ccccatgtac 180 tttttcctct tcaatttgtc ctgcatagac ctctgttatt cttctgtgtt tacacccaaa 240 atgctgatta acttcacatc caagaagaat attatttcct acagggggtg catgacccaa 300 ctttactttt tttgtttttt tgctatttct gaatgctatg tgctgacatc catggcctat 360 gatcgctatg tggccatctg taacccactt ttgtataatg ttgtcatgtc ttctaaagtg 420 tgtttcagtc ttatgcttgg ttcatatttg atggcatttt taggtgccat ggctcacacg 480 ggatacatgg tgagactgac cttctgtaat gcaaacacca tcaaccatta tttttgtgac 540 atcctccctc tattccagct ctcctgcacc agcacgtatg tgaatgagct ggtggttttc 600 attgtgggga gcatcgacat cattatgccc tgtgtcacca tctttgtgtc ttatggtttc 660 atcctttcca gcatcctgcg catcagctcc actgaaggca ggtccaaagc tttcagcact 720

Page 2127

069269_0225_SL.TXT tgcagttccc acataattgc tgtttccttg ttttttggat catgtgcatt tatgtatctt aaaccatctt ctgctgggtc tatggatgag gggaaaatct cttctatctt ttacaccaac acagttccct tgatgaaccc tttaatttac accttgagaa acaaagatgt taagcttgcc ttgaggaaaa tcctgagtag gagacagttt taa

780

840

900

933 <210> 1898 <211> 310 <212> PRT <213> Canis familiaris <400> 1898

Met Ala 1 Leu Arg Asn Ala Ser Phe Val Thr Glu Phe Ile Leu Ala 15 Gly 5 10 Leu Thr Asp Leu Pro Asp Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu 20 25 30 Leu Met Tyr Val Val Thr Val Leu Gly Asn Leu Gly Leu Ile Ile Leu 35 40 45 Ile Arg Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60 Asn Leu Ser Cys Ile Asp Leu Cys Tyr Ser Ser Val Phe Thr Pro Lys 65 70 75 80 Met Leu Ile Asn Phe Thr Ser Lys Lys Asn Ile Ile Ser Tyr Arg Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Cys Phe Phe Ala Ile Ser Glu Cys 100 105 110 Tyr Val Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Val Met Ser Ser Lys Val Cys Phe Ser Leu 130 135 140

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Met 145 Leu Gly Ser Tyr Leu Met Ala Phe Leu Gly Ala Met Ala His Thr 150 155 160 Gly Tyr Met Val Arg Leu Thr Phe Cys Asn Ala Asn Thr Ile Asn His 165 170 175 Tyr Phe Cys Asp Ile Leu Pro Leu Phe Gln Leu Ser Cys Thr Ser Thr 180 185 190 Tyr Val Asn Glu Leu Val Val Phe Ile Val Gly Ser Ile Asp Ile Ile 195 200 205 Met Pro Cys Val Thr Ile Phe Val Ser Tyr Gly Phe Ile Leu Ser Ser 210 215 220 Ile Leu Arg Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Cys Ala 245 250 255 Phe Met Tyr Leu Lys Pro Ser Ser Ala Gly Ser Met Asp Glu Gly Lys 260 265 270 Ile Ser Ser Ile Phe Tyr Thr Asn Thr Val Pro Leu Met Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Leu Ala Leu Arg Lys Ile 290 295 300 Leu Ser Arg Arg Gln Phe 305 310

<210> 1899 <211> 933 <212> DNA <213> Canis familiaris <400> 1899 atgcctcctg gaaatgcttc ttttgtgact gaattcattc tggtggggct cacagaccta

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ccagatctcc agctccccct tttctgcttg tttctactca tgtatgtggt cactgtgctg 120 ggaaatttag gcttgatcac tctaattggg ttgaattcac acctccacac ccccatgtac 180 tttttcctct tcaatttgtc cttcatagac ttctgttatt cttctgtgtt tacacccaaa 240 atgctgacta actttatatc caagaagaat atcatctcct acagggggtg catgacccag 300 ctttactttt tctgtttttt tggcatttct gaatgctatg tgctgacatc catggcctat 360 gatcgctatg tggccatctg taacccactt ttgtataatg ttgtcatgtc ctctaaagtg 420 tgttccctcc ttatgcttgg ttcatatttg atggcattct caggtgccat ggcccacact 480 ggatgcatgc tgagactgac cttctgtgat gcaaacacca tcaaccatta tttttgtgac 540 atcctccctc tgctccagct ctcctgcacc agcacgtatg tgaatgagtt ggtggttttc 600 attgtggtgg gcgtcaacat cattgtgccc actgtcacca tctttgtgtc ttatggtttc 660 atcctttcca gcatcctgcg catcagctcc actgaaggca ggtccaaagc tttcagcacc 720 tgcagttccc acataattgc tgtttctttg ttctttggat caggtgcatt tatgtatctt 780 aaaccatctt ctgttgggtc tatggatgag gggaaaatct cctctgtctt ttataccaat 840 gtggttccct tgatgaaccc gttcatttac agcttgagaa ataaagatgt taaatgttct 900 gtgagaaaaa ctctgagtag gaggcagttt tga 933

<210> 1900 <211> 310 <212> PRT <213> Canis familiaris <400> 1900

Met Pro Pro Gly Asn Ala Ser Phe Val Thr Glu Phe Ile Leu Val Gly 1 5 10 15 Leu Thr Asp Leu Pro Asp Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu 20 25 30 Leu Met Tyr Val Val Thr Val Leu Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Ile Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60

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Asn 65 Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Phe Thr Pro Lys 70 75 80 Met Leu Thr Asn Phe Ile Ser Lys Lys Asn Ile Ile Ser Tyr Arg Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Cys Phe Phe Gly Ile Ser Glu Cys 100 105 110 Tyr Val Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Val Met Ser Ser Lys Val Cys Ser Leu Leu 130 135 140 Met Leu Gly Ser Tyr Leu Met Ala Phe Ser Gly Ala Met Ala His Thr 145 150 155 160 Gly Cys Met Leu Arg Leu Thr Phe Cys Asp Ala Asn Thr Ile Asn His 165 170 175 Tyr Phe Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr 180 185 190 Tyr Val Asn Glu Leu Val Val Phe Ile Val Val Gly Val Asn Ile Ile 195 200 205 Val Pro Thr Val Thr Ile Phe Val Ser Tyr Gly Phe Ile Leu Ser Ser 210 215 220 Ile Leu Arg Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu Lys Pro Ser Ser Val Gly Ser Met Asp Glu Gly Lys 260 265 270

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Ile Ser Ser Val Phe Tyr Thr Asn Val Val Pro Leu Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Cys Ser Val Arg Lys Thr 290 295 300 Leu Ser Arg Arg Gln Phe

305 310 <210> 1901 <211> 936 <212> DNA <213> Canis familiaris <400> 1901

atggatatgg gaaacagttc cttagtcact gagtttatcc ttgtgggttt aaccaaatat 60 tcagagattc agctgcccct gttcttcctt ttcctaggaa tctacattgt cactgtgaca 120 ggaaacctgg gcttggttgc tctaattgga ctgaattctc accttcacac ccccatgtac 180 tatttcctct ttaatttatc atttattgat ctctgttatt cttccgtcat caccccaaaa 240 ctgttggtaa actttgtgtc aaagctgaac accatctctt acgcaggatg catgacgcag 300 ctctttttct actgcttctt tgttagcgca gagtgctatg tgttgacagt aatggcctat 360 gatcgctatg tggccatttg caagcccctg ctctacacag tcaccatgtc cccgcaggtc 420 tgttctctgc tggctatgat tgtatatgtg ggggcattta ttggtgcctg ggcccataca 480 ggatgcatgc tgaggttgac cttctgtgat gccaacagca tcaatcacta catgtgtgac 540 atcctccccc tcctggagct ctcctgcaca aacactcacc tcaatgaact ggtggttctc 600 attgttgtgg gctttgatgt tggtgtgccc agcctcacta tcattgtctc ctacactttc 660 atccttgcca gcatcctccg tatccgttcc atggaaggaa ggtccaaagc cttcagcact 720 tgtagctcac atataattgt tgtttctgtt ttctttgggt caggggcatt catgtatctt 780 catccttctt ctgttttgtc catggaccag gggaaagtgt ccacggtttt ctataccatt 840 gtggtgccta tgctcaatcc tctgatctac agcctcagga ataaggaggt taaggttgcc 900 ctgaaaaaaa gcttgaatag aaaaacattt tcctga 936

Page 2132

069269_0225_SL.TXT <210> 1902 <211> 311 <212> PRT <213> Canis familiaris

<400> 1902 Ile Leu Val 15 Gly Met 1 Asp Met Gly Asn Ser Ser Leu 5 Val Thr 10 Glu Phe Leu Thr Lys Tyr Ser Glu Ile Gln Leu Pro Leu Phe Phe Leu Phe Leu 20 25 30 Gly Ile Tyr Ile Val Thr Val Thr Gly Asn Leu Gly Leu Val Ala Leu 35 40 45 Ile Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 Leu Leu Val Asn Phe Val Ser Lys Leu Asn Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Met Thr Gln Leu Phe Phe Tyr Cys Phe Phe Val Ser Ala Glu Cys 100 105 110 Tyr Val Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Thr Val Thr Met Ser Pro Gln Val Cys Ser Leu Leu 130 135 140 Ala Met Ile Val Tyr Val Gly Ala Phe Ile Gly Ala Trp Ala His Thr 145 150 155 160 Gly Cys Met Leu Arg Leu Thr Phe Cys Asp Ala Asn Ser Ile Asn His 165 170 175 Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Leu Ser Cys Thr Asn Thr 180 185 190

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His Leu Asn Glu Leu Val Val Leu Ile Val Val Gly Phe Asp Val Gly 195 200 205 Val Pro Ser Leu Thr Ile Ile Val Ser Tyr Thr Phe Ile Leu Ala Ser 210 215 220 Ile Leu Arg Ile Arg Ser Met Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ile Val Val Ser Val Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu His Pro Ser Ser Val Leu Ser Met Asp Gln Gly Lys 260 265 270 Val Ser Thr Val Phe Tyr Thr Ile Val Val Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Val Ala Leu Lys Lys Ser 290 295 300 Leu Asn Arg Lys Thr Phe Ser

305 310 <210> 1903 <211> 801 <212> DNA <213> Canis familiaris <400> 1903

ctccccctcc tatttctaga gatctatctg gtggctgtag ttctcaggct gaatttgatt 60 atattaattt cactaaatac atactttcat acattcatat gatatttact ctttagtctc 120 tctgacatcg atgtctatca ctcttctgtc tttgccctca aaatactcac gaacattgta 180 tagaggaaaa cctcctatcc agggtggctg acgcaccttt atttcttttg tttctttgtc 240 atttccaaat gttatgtatc aacagcatag catataatca ctatgttgtc atttgcaagc 300 cactattgta tggtgttata ttgtcctttc agacctgttc tctgttggag tttggagcat 360

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atgtgatggg atgtctgggt ttcctagccc acactctcta tggtgagact gcccttctgt 420 gatgccagta tcgtcaacca cgatcttgac atactctctg tgctcagtca gctttcctgc 480 accaggaccg acaatgagat tatggtcttt gtcctaatag acatgaacat tttggtgccc 540 atcagcactg cttttatctc ctatgctttt atcatcacca gcaccttcca catcagctct 600 acagaggtca gggctaaagc tttcattcag aacctgtaat tcccattaat ggctgtttca 660 tttttctttg ggcagtagga ttcatgtgcc tccaaccttc taatgtagtg tctatgaatc 720 aggaaagtgg cattagtctt tgatataaat tttgggttca catcgaactc atatatctac 780 agcttgaatt cattcattct t 801 <210> 1904 <211> 37 <212> PRT <213> Canis familiaris <400> 1904 Pro Pro Pro Ile Ser Arg Asp Leu Ser Gly Gly Cys Ser Ser Gln Ala 1 5 10 15 Glu Phe Asp Tyr Ile Asn Phe Thr Lys Tyr Ile Leu Ser Tyr Ile His 20 25 30 Met Ile Phe Thr Leu 35 <210> 1905 <211> 930 <212> DNA <213> Canis familiaris <400> 1905 atggcagcta agaactcttc tgtgacagag tttatcctca caggcttaac agaccagccg 60 ggactccaga tccctctctt cttgctgttt ctaggtttct acatggtcac tctgctgggg 120 aacctgggcc taataaccct gattgggttg aattctcgcc tacacacccc catgtacttt 180 ttcctcttca atctgtcctt agtagatttc tgttactcca ctaccatcac ccccaaaatg 240 ctgaagagct ttgtctcgaa gaacatcatc ttgtatgcag agtgtatgac tcaactcttt 300 ttcttctgct tcttcgtcat ttctgagtcc ttcctcctgt cagcaatggc atatgaccgc 360

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tatgttgcca tctgcaaacc attggtgtac accctcacca tgtctcctca ggtctgttta 420 ttccttttgt tgggtgtcta tgtgatgggg ttttcagggg ccatggtcca catgggaagc 480 atagcaagtc tgactttctg tgctgacaat cttgttaatc attttatgtg tgacatcttt 540 cctctccttg agctctcctg caacagcacc tatgtgcatg agctggtggt ctttgtacgt 600 gtggccatgg acattggaat acccattgtc accatcttca tctcttatgc tctgattctc 660 tccagcattc tccatattca ctccactgag ggcaggtcca aagctttcag tacgtgcagc 720 tctcacataa ttgtggtttc tcttttcttt ggttctgggg cttttgtgta tctcaaacca 780 ccttctattt tgccccttaa ccaagggaaa gtgttctctt tgttctacac cattgtggtg 840 cccatgttaa acccgctgat ctacagtttg aggaacaagg atgtcaaagt taccttgaga 900 aaaaccttgg aaaggaaaat attttcttga 930

<210> 1906 <211> 309 <212> PRT <213> Canis familiaris <400> 1906

Met Ala Ala Lys Asn Ser Ser Val Thr Glu Phe Ile Leu Thr Gly Leu 1 5 10 15 Thr Asp Gln Pro Gly Leu Gln Ile Pro Leu Phe Leu Leu Phe Leu Gly 20 25 30 Phe Tyr Met Val Thr Leu Leu Gly Asn Leu Gly Leu Ile Thr Leu Ile 35 40 45 Gly Leu Asn Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Phe Asn 50 55 60 Leu Ser Leu Val Asp Phe Cys Tyr Ser Thr Thr Ile Thr Pro Lys Met 65 70 75 80 Leu Lys Ser Phe Val Ser Lys Asn Ile Ile Leu Tyr Ala Glu Cys Met 85 90 95

Page 2136

Thr Gln Leu Phe 100 Phe Phe Cys 069269_0225_SL.TXT Phe Phe Val Ile Ser Glu 105 Ser 110 Phe Leu Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Val Tyr Thr Leu Thr Met Ser Pro Gln Val Cys Leu Phe Leu Leu Leu 130 135 140 Gly Val Tyr Val Met Gly Phe Ser Gly Ala Met Val His Met Gly Ser 145 150 155 160 Ile Ala Ser Leu Thr Phe Cys Ala Asp Asn Leu Val Asn His Phe Met 165 170 175 Cys Asp Ile Phe Pro Leu Leu Glu Leu Ser Cys Asn Ser Thr Tyr Val 180 185 190 His Glu Leu Val Val Phe Val Arg Val Ala Met Asp Ile Gly Ile Pro 195 200 205 Ile Val Thr Ile Phe Ile Ser Tyr Ala Leu Ile Leu Ser Ser Ile Leu 210 215 220 His Ile His Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Ile Ile Val Val Ser Leu Phe Phe Gly Ser Gly Ala Phe Val 245 250 255 Tyr Leu Lys Pro Pro Ser Ile Leu Pro Leu Asn Gln Gly Lys Val Phe 260 265 270 Ser Leu Phe Tyr Thr Ile Val Val Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Val Thr Leu Arg Lys Thr Leu Glu 290 295 300

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Arg Lys Ile Phe Ser

305 <210> 1907 <211> 927 <212> DNA <213> Canis familiaris <400> 1907

atggctactt ccaatcattc ctttgtgact gaatttatcc ttgaggggtt aacaaaatgc 60 ccagagcttc aatttccact tttcctacta ttccttggag tgtatgtggt cacagtggtg 120 gggaacctgg gcatgatcct cttaattgct atcagttctc aacttcactc tccaatgtat 180 tattttcttg gtcatttgtc attcattgat ctctgttact cctctgtcat tacgccaaaa 240 atgctggtga actttgtgtc agagaagaac attatctcct ttctggcgtg catgactcag 300 ctttacttct tccttatttt tgtaattgca gaaggctacc ttctgaccgc catggcgtat 360 gaccgttatg tagccatctg tagcccactg ctttacaatg ttatcatgtc ccatagggtc 420 tgctccataa ttatggctgt ggtatattca ctgggtttgt ttggggctac tgtccatact 480 acccacatgt cagtgttgtc cttctgtggg tctcatgttg tcagtcatta tttttgtgat 540 attctcccct tattgactct ctcttgttcc agcacccaca tcaatgagac attgttgttt 600 attattggag gagttaatac cttagcacct acactggctg tattcatctc ttatgctttc 660 attctttcca gcatcctccg tattcgctct gctgagggac ggtccaaagc ctttggcact 720 tgtagctccc atatcatggc tgtggggatc ttttttgggt ctatcacatt catgtatttc 780 aagccccctt ctagcaatac tatggaagag gagaaggtgt cctcagtgtt ctacaccact 840 gtgatcccca tgctgaatcc catgatctac agcctgagga ataaagatgt gaagaatgca 900 ctgagaaagg tggttggggg aaggtag 927

<210> 1908 <211> 308 <212> PRT <213> Canis familiaris <400> 1908

Met Ala Thr Ser Asn His Ser Phe Val Thr Glu Phe Ile Leu Glu Gly 1 5 10 15

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Leu Thr Lys Cys 20 Pro Glu Leu Gln Phe Pro Leu Phe Leu Leu Phe Leu 25 30 Gly Val Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Leu Leu 35 40 45 Ile Ala Ile Ser Ser Gln Leu His Ser Pro Met Tyr Tyr Phe Leu Gly 50 55 60 His Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Val Ser Glu Lys Asn Ile Ile Ser Phe Leu Ala 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Leu Ile Phe Val Ile Ala Glu Gly 100 105 110 Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr Asn Val Ile Met Ser His Arg Val Cys Ser Ile Ile 130 135 140 Met Ala Val Val Tyr Ser Leu Gly Leu Phe Gly Ala Thr Val His Thr 145 150 155 160 Thr His Met Ser Val Leu Ser Phe Cys Gly Ser His Val Val Ser His 165 170 175 Tyr Phe Cys Asp Ile Leu Pro Leu Leu Thr Leu Ser Cys Ser Ser Thr 180 185 190 His Ile Asn Glu Thr Leu Leu Phe Ile Ile Gly Gly Val Asn Thr Leu 195 200 205 Ala Pro Thr Leu Ala Val Phe Ile Ser Tyr Ala Phe Ile Leu Ser Ser 210 215 220

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Ile Leu 225 Arg Ile Arg Ser Ala 230 Glu Gly Arg Ser Lys Ala Phe Gly Thr 235 240 Cys Ser Ser His Ile Met Ala Val Gly Ile Phe Phe Gly Ser Ile Thr 245 250 255 Phe Met Tyr Phe Lys Pro Pro Ser Ser Asn Thr Met Glu Glu Glu Lys 260 265 270 Val Ser Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Arg Lys Val 290 295 300

Val Gly Gly Arg 305 <210> 1909 <211> 939 <212> DNA <213> Canis familiaris <400> 1909

atggttgcag gaaatcattc tacagcatcc gagtttgtgt tagtgggtct aacacagcag 60 ccagagctcc agcagcctct cttcctcctg ttcctgggaa tctatatcct gacggtggtg 120 gggaacttgg gcttgattct cctgattacc ctgagccctt cccttcacac ccccatgtac 180 tacttcctca gcagcttatc attcatcgat ctctgctatt cctctgtcat tacccccaaa 240 atgctggtga acttcttagg gaggaaaaat atgatccttt attctgagtg catgacacag 300 ctctttttct tcgtggtctt tgtagtggct gagggttacc tcctgaccat gatggcatac 360 gatcgctacg ttgccatctg tagcccccta ctttacagtg tggtcatgtc cccccgagtg 420 tgctcactgc tggtgctggt tgccttcagc ctgggctttc tctccgccgt ggcccataca 480 agtgccatga tgcaactgtc tttctgcaga tcccacatca tcaaccatta cttctgtgat 540 gttcttcata tgctcaatct ctcctgctcc gatacacacc tcaatgagct tctgcttttt 600 tatcatgcgg gacttaacac ttttttatca tgcgggactt aacacttggt accactctgg 660

Page 2140

069269_0225_SL.TXT gcagtctgca tttcctatgc cttcatcttc tacagcatcg ttcgaatccg atcttcagag ggacggtcca aagcctttgg tacttgcagc tctcatctca tggctgtggg gatcttcttt gggtctatca cattcatgta tttcaagccc ccttccagta attccctgga acaagagaag gtgtcctcag tgttctacac cacagtgatc cccatgctga accctttaat atacagtctg agaaacaagg atgtcaagaa agcattgagg aaggttttg

720

780

840

900

939 <210> 1910 <211> 213 <212> PRT <213> Canis familiaris

<400> 1910 His Ser Thr Ala Ser Glu Phe Val Leu 10 Val 15 Gly Met 1 Val Ala Gly Asn 5 Leu Thr Gln Gln Pro Glu Leu Gln Gln Pro Leu Phe Leu Leu Phe Leu 20 25 30 Gly Ile Tyr Ile Leu Thr Val Val Gly Asn Leu Gly Leu Ile Leu Leu 35 40 45 Ile Thr Leu Ser Pro Ser Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Ser Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Gly Arg Lys Asn Met Ile Leu Tyr Ser Glu 85 90 95 Cys Met Thr Gln Leu Phe Phe Phe Val Val Phe Val Val Ala Glu Gly 100 105 110 Tyr Leu Leu Thr Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125

Pro Leu Leu Tyr Ser Val Val Met 130 135

Ser Pro Arg Val 140

Cys Ser Leu Leu

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069269_0225_SL.TXT

Val 145 Leu Val Ala Phe Ser Leu Gly Phe Leu Ser Ala Val Ala His Thr 150 155 160 Ser Ala Met Met Gln Leu Ser Phe Cys Arg Ser His Ile Ile Asn His 165 170 175 Tyr Phe Cys Asp Val Leu His Met Leu Asn Leu Ser Cys Ser Asp Thr 180 185 190 His Leu Asn Glu Leu Leu Leu Phe Tyr His Ala Gly Leu Asn Thr Phe 195 200 205 Leu Ser Cys Gly Thr

210 <210> 1911 <211> 942 <212> DNA <213> Canis familiaris <400> 1911 atggatacag aaaatcattc ttcagttact gagtttatcc ttgaggggtt aacagaccag cctggactcc agctccctct ctttgtcctg tttctactta tctatatggt ctgcatcatg ggaaatatgg gcttgatctt tttaatcaga atcagttctc agtttcatat gcccatgtat tattttctca gtaatctgtc cttcatagat ctctgctact ccactgtcat aattcccaag ctgttggtga actttgtttc agaaaagaat ctcacctcct ttcctgagtg catggctcaa ctctttttct tctgcttctt tggtattgat gactcctaca tgctgacagc aatggcatat gatcgttatg ttgctatctg taaccccttg ctctataatg tcaccatgtc caacagaatc tgttttctac tggtcaccag tgtgtataca gtgggcgcca ttggagcctt agtccacacc agctacatat ctagtcgatc cttctgtgga actaatatca tccaccatta cttctgtgac atccttcctc ttctgaatat atcttgttca agagactcca ccaaggaact cttggtaatg attttggttg gattcaatgt atttgcatgt gctttagcca tctttatctc ttatgccttc attctttcca gcatcttatg catccactca gctgaaggca ggtccaaagc tttcagtacc

120

180

240

300

360

420

480

540

600

660

720

Page 2142

069269_0225_SL.TXT tgcagttccc accttgcagc tgttggggtc ttctatggct ccatcatctt catgtatttt aaaccatctt ccagcaacat aatacaggag aaggtggctt ctgtgtttta taccacagtg attcccatgc ttaaccccct tatctatagc cttaggaaca aggatgtcaa ggaatccctt aaaaaagtcc taaataatgg gttactttct cagtctgcat ag

780

840

900

942 <210> 1912 <211> 313 <212> PRT <213> Canis familiaris

<400> 1912 His Ser Ser Val Thr Glu Phe Ile Leu Glu Gly Met Asp 1 Thr Glu Asn 5 10 15 Leu Thr Asp Gln Pro Gly Leu Gln Leu Pro Leu Phe Val Leu Phe Leu 20 25 30 Leu Ile Tyr Met Val Cys Ile Met Gly Asn Met Gly Leu Ile Phe Leu 35 40 45 Ile Arg Ile Ser Ser Gln Phe His Met Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Thr Val Ile Ile Pro Lys 65 70 75 80 Leu Leu Val Asn Phe Val Ser Glu Lys Asn Leu Thr Ser Phe Pro Glu 85 90 95 Cys Met Ala Gln Leu Phe Phe Phe Cys Phe Phe Gly Ile Asp Asp Ser 100 105 110 Tyr Met Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Thr Met Ser Asn Arg Ile Cys Phe Leu Leu 130 135 140 Val Thr Ser Val Tyr Thr Val Gly Ala Ile Gly Ala Leu Val His Thr Page 2143

0 6926 9_02 25_S .L.TX T 145 150 155 160 Ser Tyr Ile Ser Ser Arg Ser Phe Cys Gly Thr Asn Ile Ile His His 165 170 175 Tyr Phe Cys Asp Ile Leu Pro Leu Leu Asn Ile Ser Cys Ser Arg Asp 180 185 190 Ser Thr Lys Glu Leu Leu Val Met Ile Leu Val Gly Phe Asn Val Phe 195 200 205 Ala Cys Ala Leu Ala Ile Phe Ile Ser Tyr Ala Phe Ile Leu Ser Ser 210 215 220 Ile Leu Cys Ile His Ser Ala Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ala Ala Val Gly Val Phe Tyr Gly Ser Ile Ile 245 250 255 Phe Met Tyr Phe Lys Pro Ser Ser Ser Asn Ile Ile Gln Glu Lys Val 260 265 270 Ala Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ser Leu Lys Lys Val Leu 290 295 300 Asn Asn Gly Leu Leu Ser Gln Ser Ala 305 310

<210> 1913 <211> 933 <212> DNA <213> Canis familiaris <400> 1913 atgaggaatg cctcagtggt gaccaagttt atcctgctgg gcatcccaca caccgagggt ctggagacca cgctctttgt cctgtttttg agcttctata tcttcactct tatggggaac

120

Page 2144

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ctgctcatcc tactggcgat tatctcctcc actcggcttc acactcctat gtacttcttc 180 ctgtgtcaac tgtctgtgtg tgacatattt ttcccttctg tgagttcccc caagatgctc 240 ttctacctct cagggaacag ccgggtcatc tcctatgcag gctgcgtgtc ccagctcttc 300 ttctaccatt tcctgggctg taccgagtgc ttcctgtaca cagtgatggc ctatgaccgc 360 tttgtcgcca tatgttaccc tctacgctac acggtgatca tgagccacag agtgtgtgcc 420 atcctggcca tggggacctc cttttttggc tgcattcagg ccacctttct aaccactctc 480 accttccagt tgccctactg tggcgccaat gaggtggact atttcttctg tgatatcccg 540 gtgatgctga agctggcttg tgctgatacc tcagccctgg agatggtggg cttcatcagc 600 gtgggcctca tgcccctcag ttgcttcctt ctcatcctca cctcctacag ctgcattgtg 660 tgttccatcc tacagatccg gtctcctgaa ggcagacgcc gtgccttttc cacctgcagt 720 gcccacctca ctgccatcct cctctccttt atgccagtgg tcctcatcta cctgcagccc 780 acccccaatc cctggctcaa tgcaactgtt caggtcctga ataacctggt cactcctatg 840 ctgaatccgt tgatctacag cctaagaaat aaagaagtaa aatattctct gaggaaggtg 900 ctacagcaag tagccttctt tcctgagaag tga 933

<210> 1914 <211> 310 <212> PRT <213> Canis familiaris <400> 1914

Met Arg Asn Ala Ser Val Val Thr Lys Phe Ile Leu Leu Gly Ile Pro 1 5 10 15 His Thr Glu Gly Leu Glu Thr Thr Leu Phe Val Leu Phe Leu Ser Phe 20 25 30 Tyr Ile Phe Thr Leu Met Gly Asn Leu Leu Ile Leu Leu Ala Ile Ile 35 40 45 Ser Ser Thr Arg Leu His Thr Pro Met Tyr Phe Phe Leu Cys Gln Leu 50 55 60

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Ser 65 Val Cys Asp Ile Phe 70 Phe Pro Ser Val Ser Ser 75 Pro Lys Met Leu 80 Phe Tyr Leu Ser Gly Asn Ser Arg Val Ile Ser Tyr Ala Gly Cys Val 85 90 95 Ser Gln Leu Phe Phe Tyr His Phe Leu Gly Cys Thr Glu Cys Phe Leu 100 105 110 Tyr Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Tyr Pro Leu 115 120 125 Arg Tyr Thr Val Ile Met Ser His Arg Val Cys Ala Ile Leu Ala Met 130 135 140 Gly Thr Ser Phe Phe Gly Cys Ile Gln Ala Thr Phe Leu Thr Thr Leu 145 150 155 160 Thr Phe Gln Leu Pro Tyr Cys Gly Ala Asn Glu Val Asp Tyr Phe Phe 165 170 175 Cys Asp Ile Pro Val Met Leu Lys Leu Ala Cys Ala Asp Thr Ser Ala 180 185 190 Leu Glu Met Val Gly Phe Ile Ser Val Gly Leu Met Pro Leu Ser Cys 195 200 205 Phe Leu Leu Ile Leu Thr Ser Tyr Ser Cys Ile Val Cys Ser Ile Leu 210 215 220 Gln Ile Arg Ser Pro Glu Gly Arg Arg Arg Ala Phe Ser Thr Cys Ser 225 230 235 240 Ala His Leu Thr Ala Ile Leu Leu Ser Phe Met Pro Val Val Leu Ile 245 250 255 Tyr Leu Gln Pro Thr Pro Asn Pro Trp Leu Asn Ala Thr Val Gln Val 260 265 270

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Leu Asn Asn Leu Val Thr Pro Met 280 Leu Asn Pro Leu Ile Tyr Ser 285 Leu 275 Arg Asn Lys Glu Val Lys Tyr Ser Leu Arg Lys Val Leu Gln Gln Val 290 295 300 Ala Phe Phe Pro Glu Lys 305 310

<210> 1915 <211> 936 <212> DNA <213> Canis familiaris <400> 1915

atggtagcgg gaaatcactc cacagtgact gaattcatcc tcgctgggct aacacaacaa 60 ccggaactcc agctgcccct tttcttcctc ttcctaggaa tctatgtggt cacggtggtg 120 gggaacctgg gcatgatcat gctgataggg ctcagtgctc acctgcacac gcccatgtat 180 tacttcctca gtagcttgtc cttcattgac ctctgccatt ccactgtcat tacccccaaa 240 atgctggaga actttgtgac agagatgaat gtcatctcct accctgaatg catgactcag 300 ctctatttct tccttgtttt tgctattgca gagtgttaca tgttagcagt aatggcctat 360 gaccgctatg ttgccatctg tagccccttg ctttacaatg tcatcatggc ccatcaggct 420 tgtttctccc tgatttcagg agtgtatatt atagccctgg tttgtgcatt tgttcataca 480 ggttgcatgt ttagggttca tttctgcaaa tttgatgtga tcaatcatta tttctgtgat 540 cttctttcct tgttaaaact ctcctgttct aatacccatg tcaatgagtt agtgattcta 600 atctttagta cagttaatat ccttgccccc agcctgacga tccttgcctc ctatgtcttc 660 atcctctcca gcatcctcca catccgctcc actgagggca ggtccaaagc cttcagcacc 720 tgcagttctc acatctcagc tgttgctgtc ttctttggat ctgctgcatt catgtacctg 780 cagccgtcat ctgtgagctc catggaccaa gggaaagtat cctctgtgtt ttataccatc 840 attgtgccca tgctgaaccc cctgatctac agcctgagga ataaggatgt caatgctgcc 900 ctgaagaaaa tcttagagag aagaatattc ttgtga 936

<210> 1916

Page 2147

069269_0225_SL.TXT <211> 311 <212> PRT <213> Canis familiaris

<400> 1916 Ile Leu Ala 15 Gly Met 1 Val Ala Gly Asn His Ser Thr 5 Val Thr 10 Glu Phe Leu Thr Gln Gln Pro Glu Leu Gln Leu Pro Leu Phe Phe Leu Phe Leu 20 25 30 Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Met Leu 35 40 45 Ile Gly Leu Ser Ala His Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Ser Leu Ser Phe Ile Asp Leu Cys His Ser Thr Val Ile Thr Pro Lys 65 70 75 80 Met Leu Glu Asn Phe Val Thr Glu Met Asn Val Ile Ser Tyr Pro Glu 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Leu Val Phe Ala Ile Ala Glu Cys 100 105 110 Tyr Met Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr Asn Val Ile Met Ala His Gln Ala Cys Phe Ser Leu 130 135 140 Ile Ser Gly Val Tyr Ile Ile Ala Leu Val Cys Ala Phe Val His Thr 145 150 155 160 Gly Cys Met Phe Arg Val His Phe Cys Lys Phe Asp Val Ile Asn His 165 170 175 Tyr Phe Cys Asp Leu Leu Ser Leu Leu Lys Leu Ser Cys Ser Asn Thr 180 185 190

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His Val Asn Glu Leu Val Ile Leu Ile Phe Ser Thr Val Asn Ile Leu 195 200 205 Ala Pro Ser Leu Thr Ile Leu Ala Ser Tyr Val Phe Ile Leu Ser Ser 210 215 220 Ile Leu His Ile Arg Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ser Ala Val Ala Val Phe Phe Gly Ser Ala Ala 245 250 255 Phe Met Tyr Leu Gln Pro Ser Ser Val Ser Ser Met Asp Gln Gly Lys 260 265 270 Val Ser Ser Val Phe Tyr Thr Ile Ile Val Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Asn Ala Ala Leu Lys Lys Ile 290 295 300 Leu Glu Arg Arg Ile Phe Leu

305 310 <210> 1917 <211> 936 <212> DNA <213> Canis familiaris <400> 1917

atggaccctg gaaatcattc catagtgact gagttcatcc tcgctgggct aacagagaaa 60 ccagaactcc aactgcccct tttcttcctc ttcctaggaa tctatgtggt cacagtggtg 120 gggaacctgg gcatgatcat gctgataggg ctcagtgctc acttgcacac ccccatgtac 180 tacttcctca gcaatttgtc cttcattgat ctctgccatt ccactgtcgt tacccccaaa 240 atgctggtga actttgtgac acagaagaac atcactccct actctgaatg catgactcag 300 ctctatttct tcctgatttt tgccattgca gagtgtcaca tgttggctgc aatggcttat 360 gaccgctatg ctgccatctg taaccctttg ctttacaatg tcatcatgtc ttctcagatc 420

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tgcttctgga tgacagtggg agtttatatt ttgggcatcg ttggatctac aatccacacg 480 ggctttatga tgagactcct tttctgcaag agcaatgtgg ttaatcatta tttctgtgat 540 ctcttcccag tcttggaatt atcctgttcc agcacctaca ttaatgaatt actggttcta 600 gtcttgagtg catttaacat tttgactcct gccttaacta tccttgcctc ctacatcttc 660 atcctctcca gcatcctcca catccgctcc actgagggca ggtccaaagc cttcagcacc 720 tgcagttctc acatctcagc tgttactgtc ttttttggat ctgctgcatt catgtacctg 780 cagccgtcat ctgtgagctc catggaccaa gggaaagtgt cctctgtgtt ttataccatc 840 attgtgccca tgttgaaccc tttgatctat agcctgagga ataaggatgt caaatttgcc 900 ctgaagaaaa ttctggttgg tagaaaatgt tcataa 936

<210> 1918 <211> 311 <212> PRT <213> Canis familiaris

<400> 1918 His Ser Ile Val Thr Glu Phe Ile Leu Ala Gly Met Asp 1 Pro Gly Asn 5 10 15 Leu Thr Glu Lys Pro Glu Leu Gln Leu Pro Leu Phe Phe Leu Phe Leu 20 25 30 Gly Ile Tyr Val Val Thr Val Val Gly Asn Leu Gly Met Ile Met Leu 35 40 45 Ile Gly Leu Ser Ala His Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys His Ser Thr Val Val Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Val Thr Gln Lys Asn Ile Thr Pro Tyr Ser Glu 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Leu Ile Phe Ala Ile Ala Glu Cys 100 105 110

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His Met Leu 115 Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Asn 120 125 Pro Leu Leu Tyr Asn Val Ile Met Ser Ser Gln Ile Cys Phe Trp Met 130 135 140 Thr Val Gly Val Tyr Ile Leu Gly Ile Val Gly Ser Thr Ile His Thr 145 150 155 160 Gly Phe Met Met Arg Leu Leu Phe Cys Lys Ser Asn Val Val Asn His 165 170 175 Tyr Phe Cys Asp Leu Phe Pro Val Leu Glu Leu Ser Cys Ser Ser Thr 180 185 190 Tyr Ile Asn Glu Leu Leu Val Leu Val Leu Ser Ala Phe Asn Ile Leu 195 200 205 Thr Pro Ala Leu Thr Ile Leu Ala Ser Tyr Ile Phe Ile Leu Ser Ser 210 215 220 Ile Leu His Ile Arg Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ser Ala Val Thr Val Phe Phe Gly Ser Ala Ala 245 250 255 Phe Met Tyr Leu Gln Pro Ser Ser Val Ser Ser Met Asp Gln Gly Lys 260 265 270 Val Ser Ser Val Phe Tyr Thr Ile Ile Val Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Phe Ala Leu Lys Lys Ile 290 295 300 Leu Val Gly Arg Lys Cys Ser

305 310

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069269_0225_SL.TXT <210> 1919 <211> 960 <212> DNA <213> Canis familiaris <400> 1919

atgggagcag aaaatcactc cacagtgact gatttcatcc ttgctgggct aacagagaaa 60 ccagaactcc aactgcccct tttcttcctc ttcctaggaa tctatgcagt cacagtggtg 120 gggaacctgg gcatgatcat gctgataggg atcagtgctc acctgcacac acccatgtat 180 tacttcctca gtagcttgtc cttcattgat ctctgccatt ccactgttgt tactcccaaa 240 atgctgatga actttgtgac agagaggaat tttatctcct atgaaggctg catgactcag 300 ctttacttct tccttgtttt tgttatatca gaatgtcaca tgttggctgc aatggcctat 360 gatcgctacg ttgccatctg taacccattg ctttacaatg tcaccatgtc ttatcaggtc 420 tgttcctggc tggtaggtgg ggtgtatatc atgggcttga ctggtgccac agctcacaca 480 ggctgcatgc taagagtgct tttctgcaag gctgatagaa tcaaccatta cttctgtgat 540 ctcttcccac tattggagct ctcctgctcc agtacttata tcaacgaggt ggtagttttg 600 tgcttcagtg cagttaatat ccttgtcccc agcctgacga tccttgcctc ctacatcttc 660 atcctctcta gcatcctccg catccgctcc actgagggca ggtccaaagc cttcagcacc 720 tgcagctctc acatctcagc tgttgttgtc ttctttggat ctgctgcatt catgtacctg 780 cagccatcat ctgtgagctc catggaccaa gggaaagtgt cctctgtgtt ttataccatc 840 attgtgccca tgctgaaccc cctgatctac agcctgagga ataaagatgt cagagtcgcc 900 ctaaagaaga tccttgaaaa aagaaggaaa acggtatttt gcctgagcaa aaatttttaa 960

<210> 1920 <211> 319 <212> PRT <213> Canis familiaris <400> 1920

Met Gly Ala Glu Asn His Ser Thr Val Thr Asp Phe Ile Leu Ala Gly

1 5 10 15

Leu Thr Glu Lys Pro Glu Leu Gln Leu Pro Leu Phe Phe Leu Phe Leu

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Gly Ile Tyr 35 Ala Val Thr Val Val Gly Asn Leu Gly Met Ile Met Leu 40 45 Ile Gly Ile Ser Ala His Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Ser Leu Ser Phe Ile Asp Leu Cys His Ser Thr Val Val Thr Pro Lys 65 70 75 80 Met Leu Met Asn Phe Val Thr Glu Arg Asn Phe Ile Ser Tyr Glu Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Leu Val Phe Val Ile Ser Glu Cys 100 105 110 His Met Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Thr Met Ser Tyr Gln Val Cys Ser Trp Leu 130 135 140 Val Gly Gly Val Tyr Ile Met Gly Leu Thr Gly Ala Thr Ala His Thr 145 150 155 160 Gly Cys Met Leu Arg Val Leu Phe Cys Lys Ala Asp Arg Ile Asn His 165 170 175 Tyr Phe Cys Asp Leu Phe Pro Leu Leu Glu Leu Ser Cys Ser Ser Thr 180 185 190 Tyr Ile Asn Glu Val Val Val Leu Cys Phe Ser Ala Val Asn Ile Leu 195 200 205 Val Pro Ser Leu Thr Ile Leu Ala Ser Tyr Ile Phe Ile Leu Ser Ser 210 215 220 Ile Leu Arg Ile Arg Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr

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0 6926 9_02 25_S L.TX T 225 230 235 240 Cys Ser Ser His Ile Ser Ala Val Val Val Phe Phe Gly Ser Ala Ala 245 250 255 Phe Met Tyr Leu Gln Pro Ser Ser Val Ser Ser Met Asp Gln Gly Lys 260 265 270 Val Ser Ser Val Phe Tyr Thr Ile Ile Val Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Arg Val Ala Leu Lys Lys Ile 290 295 300 Leu Glu Lys Arg Arg Lys Thr Val Phe Cys Leu Ser Lys Asn Phe 305 310 315

<210> 1921 <211> 942 <212> DNA <213> Canis familiaris <400> 1921

atggagaaga agaactgctc ggtggtgact gaattcatcc tgctggggat tccacacaca 60 aaggggctgg agactatgct ttttgtcttg ttcttaccct tctatgcctg caccctgcta 120 ggaaatgtgt ccatcctcat ggctattctt tcttccactc gccttcacac acccatgtat 180 ttttttctgg ggaacttgtc tgtgtttgac atgagtttct cttctgtgac ctgtcctaaa 240 atgctgttgt acctcatggg actgagccca ctcatttcct ataagagttg tgtctcccag 300 ctcttcttct tccatttcct tggcagcatt gaatgcttct tgtataccgt gatggcctat 360 gaccgcttca ctgctatctg ttaccctctg cggtacacag tcatcatgag tcctagaatc 420 tgtggggccc tggctgcagg cacatggctg ttagggtgta tccattccag tatcttgact 480 ttcctcacct tcactttgcc atactgtggt cccaatgaag tggatcactt cttttgtgac 540 attccggcac ttttgccact ggcctgtgct gatacatcct tagcccagag ggtgagtttc 600 accaacgttg gcctggtgtc tctcctctgc tttctcctaa tcattttatc ctacactcga 660 atcaccatct ccatcttgca tattcattca accgaaggcc gccgccgggc cttctccact 720

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069269_0225_SL.TXT tgtagtgccc acctcattgc catcctttgt gcctatggac ccatcatcac cgtctacttg cagcccacgc ctaaccccat gctgggaact gtggtgcaaa ttctgatgaa cctcgtagga ccaatgctga atcctttgat ctataccttg aggaataagg aagtgaaaac agccctaaaa ataattttgc acaggacaag ccacattcct gagagccagt aa

780

840

900

942 <210> 1922 <211> 313 <212> PRT <213> Canis familiaris <400> 1922

Met 1 Glu Lys Lys Asn Cys 5 Ser Val Val Thr Glu Phe Ile Leu Leu Gly 10 15 Ile Pro His Thr Lys Gly Leu Glu Thr Met Leu Phe Val Leu Phe Leu 20 25 30 Pro Phe Tyr Ala Cys Thr Leu Leu Gly Asn Val Ser Ile Leu Met Ala 35 40 45 Ile Leu Ser Ser Thr Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Val Phe Asp Met Ser Phe Ser Ser Val Thr Cys Pro Lys 65 70 75 80 Met Leu Leu Tyr Leu Met Gly Leu Ser Pro Leu Ile Ser Tyr Lys Ser 85 90 95 Cys Val Ser Gln Leu Phe Phe Phe His Phe Leu Gly Ser Ile Glu Cys 100 105 110 Phe Leu Tyr Thr Val Met Ala Tyr Asp Arg Phe Thr Ala Ile Cys Tyr 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Ser Pro Arg Ile Cys Gly Ala Leu 130 135 140

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Ala 145 Ala Gly Thr Trp Leu 150 Leu Gly Cys Ile His Ser Ser Ile Leu Thr 155 160 Phe Leu Thr Phe Thr Leu Pro Tyr Cys Gly Pro Asn Glu Val Asp His 165 170 175 Phe Phe Cys Asp Ile Pro Ala Leu Leu Pro Leu Ala Cys Ala Asp Thr 180 185 190 Ser Leu Ala Gln Arg Val Ser Phe Thr Asn Val Gly Leu Val Ser Leu 195 200 205 Leu Cys Phe Leu Leu Ile Ile Leu Ser Tyr Thr Arg Ile Thr Ile Ser 210 215 220 Ile Leu His Ile His Ser Thr Glu Gly Arg Arg Arg Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Ile Ala Ile Leu Cys Ala Tyr Gly Pro Ile Ile 245 250 255 Thr Val Tyr Leu Gln Pro Thr Pro Asn Pro Met Leu Gly Thr Val Val 260 265 270 Gln Ile Leu Met Asn Leu Val Gly Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Glu Val Lys Thr Ala Leu Lys Ile Ile Leu His 290 295 300 Arg Thr Ser His Ile Pro Glu Ser Gln 305 310

<210> 1923 <211> 936 <212> DNA <213> Canis familiaris <400> 1923 atggaagtga ggaatcacac tttggttaca gagttcatcc tgctgggcat cccacacaca

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gaagggcaag aaaccatgct ctttgttgtg ttctctgtct tctacctctg caccctacta 120 ggaaatctgc tcatccttgt ggctgtgatg tctgactccc acctccacac tcctatgtat 180 ttctttcttt gtaacctctc tgtgctagat attggcttct cttctgtgag cacgccgaag 240 atgttggcca acctgctggt gaggaaccga gtcatctccc tggggggctg catgtctcag 300 gtcttttttt accacttcct cggcagcact gagtgtctgc tctacacggt gatggcgtat 360 gaccggtttg ctgccatctg ccacccactg cgttatacca ccatcatgaa ccgccgggtg 420 tgtgccttgc tggctgctgg aacctggttt actagctctt ttcatgccac aatcctcacc 480 actctgacct tccaactgcc ctactgtggg tctaatgagg tagactattt cttttgtgac 540 atctttcctg tagtcaaatt ggcgtgtggt aataccctca tcattgagac agtgagcttc 600 accaacatcg gccttgtgcc catgatgtgt tttctgctca tccttgcctc ttacatccgc 660 attgtcattg caatcctaaa gatgcactct gctgagggga ggcgcaaggc agcgtctacc 720 tgtgtctccc acctctcggt ggtcacactg ttctttgggc cctgtgccct catctatacc 780 cagccatctt tgagcgaggt actcgtaacc ccagtgcaaa tctttggcaa tgtagtcacc 840 cccatgctga accccacaat ctacactctg agaaacaaag atgtcaaagg agccttgaaa 900 aaactggcta cgggccagat agtttcaggt cactag 936

<210> 1924 <211> 311 <212> PRT <213> Canis familiaris <400> 1924

Met Glu Val Arg Asn His Thr Leu Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Ile Pro His Thr Glu Gly Gln Glu Thr Met Leu Phe Val Val Phe Ser 20 25 30 Val Phe Tyr Leu Cys Thr Leu Leu Gly Asn Leu Leu Ile Leu Val Ala 35 40 45 Val Met Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60

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Asn 65 Leu Ser Val Leu Asp Ile Gly Phe Ser Ser Val Ser Thr Pro Lys 70 75 80 Met Leu Ala Asn Leu Leu Val Arg Asn Arg Val Ile Ser Leu Gly Gly 85 90 95 Cys Met Ser Gln Val Phe Phe Tyr His Phe Leu Gly Ser Thr Glu Cys 100 105 110 Leu Leu Tyr Thr Val Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Thr Ile Met Asn Arg Arg Val Cys Ala Leu Leu 130 135 140 Ala Ala Gly Thr Trp Phe Thr Ser Ser Phe His Ala Thr Ile Leu Thr 145 150 155 160 Thr Leu Thr Phe Gln Leu Pro Tyr Cys Gly Ser Asn Glu Val Asp Tyr 165 170 175 Phe Phe Cys Asp Ile Phe Pro Val Val Lys Leu Ala Cys Gly Asn Thr 180 185 190 Leu Ile Ile Glu Thr Val Ser Phe Thr Asn Ile Gly Leu Val Pro Met 195 200 205 Met Cys Phe Leu Leu Ile Leu Ala Ser Tyr Ile Arg Ile Val Ile Ala 210 215 220 Ile Leu Lys Met His Ser Ala Glu Gly Arg Arg Lys Ala Ala Ser Thr 225 230 235 240 Cys Val Ser His Leu Ser Val Val Thr Leu Phe Phe Gly Pro Cys Ala 245 250 255 Leu Ile Tyr Thr Gln Pro Ser Leu Ser Glu Val Leu Val Thr Pro Val 260 265 270

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Gln Ile Phe Gly Asn Val Val Thr Pro Met Leu Asn Pro Thr Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Lys Lys Leu Ala Thr 290 295 300 Gly Gln Ile Val Ser Gly His 305 310

<210> 1925 <211> 936 <212> DNA <213> Canis familiaris <400> 1925

atgaggaatc tatcagtagt gactgaattt atcctgctgg gcatcccaca caccgagggt 60 ctggagacca cgctctttgt cctgtttttg agcttctata tcttcactct tatggggaac 120 ctgctcatcc tactggcgat tatctcctcc actcggcttc acactcctat gtacttcttc 180 ctgtgtcaac tgtctgtgtg cgacatattt ttcccttctg tgagttcccc caagatgctc 240 ttctacctct cagggaacag ccgggtcatc tcctatgcag gctgcgtgtc ccagctcttc 300 ttctaccatt tcctgggctg taccgagtgc ttcctgtaca cagtgatggc ctatgaccgc 360 tttgtcgcca tatgttaccc tctacgctac acggtgatca tgagccacag agtgtgtgcc 420 atcctggcca tggggacctc cttttttggc tgcattcagg ccacctttct aaccactctc 480 accttccagt tgccctactg tggcgccaat gaggtggact atttcttctg tgatatcccg 540 gtgatgctga agctggcttg tgctgatacc tcagccctgg agatggtggg cttcatcagc 600 gtgggcctca tgcccctcag ttgcttcctt ctcatcctca cctcctacag tcgcattgtt 660 tactccatcc tgcagatccg ctctgcagag ggccgacgcc gtgccttctc cacctgcagt 720 gcccacctca ctgccatctt acttttctac atgccagtgg tcctcatcta cctgaggcca 780 accccaagcc cctggctgga tgcaactgtt caggtcctga ataacctggt cacccctatg 840 ctgaacccct tgatctacag cctcaggaat aaggaagtaa agtcatctct gaggaaggtg 900 ctatatcact tgggcttcct tcctgagcag ttgtag 936

Page 2159

069269_0225_SL.TXT <210> 1926 <211> 311 <212> PRT <213> Canis familiaris

<400> 1926 Met 1 Arg Asn Leu Ser Val Val Thr 5 Glu Phe 10 Ile Leu Leu Gly Ile Pro 15 His Thr Glu Gly Leu Glu Thr Thr Leu Phe Val Leu Phe Leu Ser Phe 20 25 30 Tyr Ile Phe Thr Leu Met Gly Asn Leu Leu Ile Leu Leu Ala Ile Ile 35 40 45 Ser Ser Thr Arg Leu His Thr Pro Met Tyr Phe Phe Leu Cys Gln Leu 50 55 60 Ser Val Cys Asp Ile Phe Phe Pro Ser Val Ser Ser Pro Lys Met Leu 65 70 75 80 Phe Tyr Leu Ser Gly Asn Ser Arg Val Ile Ser Tyr Ala Gly Cys Val 85 90 95 Ser Gln Leu Phe Phe Tyr His Phe Leu Gly Cys Thr Glu Cys Phe Leu 100 105 110 Tyr Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Tyr Pro Leu 115 120 125 Arg Tyr Thr Val Ile Met Ser His Arg Val Cys Ala Ile Leu Ala Met 130 135 140 Gly Thr Ser Phe Phe Gly Cys Ile Gln Ala Thr Phe Leu Thr Thr Leu 145 150 155 160 Thr Phe Gln Leu Pro Tyr Cys Gly Ala Asn Glu Val Asp Tyr Phe Phe 165 170 175 Cys Asp Ile Pro Val Met Leu Lys Leu Ala Cys Ala Asp Thr Ser Ala 180 185 190

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Leu Glu Met Val Gly Phe Ile Ser Val Gly Leu Met Pro Leu Ser Cys 195 200 205 Phe Leu Leu Ile Leu Thr Ser Tyr Ser Arg Ile Val Tyr Ser Ile Leu 210 215 220 Gln Ile Arg Ser Ala Glu Gly Arg Arg Arg Ala Phe Ser Thr Cys Ser 225 230 235 240 Ala His Leu Thr Ala Ile Leu Leu Phe Tyr Met Pro Val Val Leu Ile 245 250 255 Tyr Leu Arg Pro Thr Pro Ser Pro Trp Leu Asp Ala Thr Val Gln Val 260 265 270 Leu Asn Asn Leu Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu 275 280 285 Arg Asn Lys Glu Val Lys Ser Ser Leu Arg Lys Val Leu Tyr His Leu 290 295 300 Gly Phe Leu Pro Glu Gln Leu

305 310 <210> 1927 <211> 864 <212> DNA <213> Canis familiaris <400> 1927

atgcccctct tcttcctgtt cctaggtttt tatgtggtca ccgtggtggg gaacctgggc 60 ctcataaccc tgattgggct gaattctcac cttcatattc ccatgtactt cttcctcctc 120 aacttgtcct tcatagattt tagtttctct actgccatca tccccaaaat gctaatgagt 180 tttgtctcca agaaaaacat catttcctat gtggggtgta tgactcagct ctttttcttt 240 tgtttttttg tcttttctga atcctatatc ttgtcagcaa tggcatatga ccgctatgtc 300 gccatctgta aaccactgct gtacatggtc accatgtctc ctcaggtgtg tttactcctt 360

Page 2161

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ttgttgggtg tttatgggat gggggtgttt ggggctgtgg cccatacagg aaatatatta 420 tttctgacct tttgtgctga caaccttgtc aatcactata tgtgtgatat cattcccctc 480 cttgagctct cctgcaacag ctcttacata aatttgctgg tggtcttcat tgttgtgacc 540 attggcattg gggtgcctat tgctgccatt ttcatctctt atggtttcat tatttccaac 600 attttccata ttagctccac tgaaggaagg tccaaagcct ttagtacctg cagctctcac 660 ataattgctg tttctctctt ctttggatca ggagctttta tgtacctcaa accaccttct 720 attttacccc ttgaccaggg gaaaatgtct tccttgttct acaccattct tgtgccaatg 780 ttcaacccat taatctatag tctaaggaat aaggatgtca aatttgccct gaggaaaacc 840 ttgggcagaa taaccttctc ttga 864

<210> 1928 <211> 287 <212> PRT <213> Canis familiaris <400> 1928

Met Pro Leu Phe Phe Leu Phe Leu Gly Phe Tyr Val Val Thr Val Val 1 5 10 15 Gly Asn Leu Gly Leu Ile Thr Leu Ile Gly Leu Asn Ser His Leu His 20 25 30 Ile Pro Met Tyr Phe Phe Leu Leu Asn Leu Ser Phe Ile Asp Phe Ser 35 40 45 Phe Ser Thr Ala Ile Ile Pro Lys Met Leu Met Ser Phe Val Ser Lys 50 55 60 Lys Asn Ile Ile Ser Tyr Val Gly Cys Met Thr Gln Leu Phe Phe Phe 65 70 75 80 Cys Phe Phe Val Phe Ser Glu Ser Tyr Ile Leu Ser Ala Met Ala Tyr 85 90 95 Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu Leu Tyr Met Val Thr Met 100 105 110

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Ser Pro Gln 115 Val Cys Leu Leu Leu Leu Leu Gly Val Tyr Gly Met Gly 120 125 Val Phe Gly Ala Val Ala His Thr Gly Asn Ile Leu Phe Leu Thr Phe 130 135 140 Cys Ala Asp Asn Leu Val Asn His Tyr Met Cys Asp Ile Ile Pro Leu 145 150 155 160 Leu Glu Leu Ser Cys Asn Ser Ser Tyr Ile Asn Leu Leu Val Val Phe 165 170 175 Ile Val Val Thr Ile Gly Ile Gly Val Pro Ile Ala Ala Ile Phe Ile 180 185 190 Ser Tyr Gly Phe Ile Ile Ser Asn Ile Phe His Ile Ser Ser Thr Glu 195 200 205 Gly Arg Ser Lys Ala Phe Ser Thr Cys Ser Ser His Ile Ile Ala Val 210 215 220 Ser Leu Phe Phe Gly Ser Gly Ala Phe Met Tyr Leu Lys Pro Pro Ser 225 230 235 240 Ile Leu Pro Leu Asp Gln Gly Lys Met Ser Ser Leu Phe Tyr Thr Ile 245 250 255 Leu Val Pro Met Phe Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp 260 265 270 Val Lys Phe Ala Leu Arg Lys Thr Leu Gly Arg Ile Thr Phe Ser 275 280 285

<210> 1929 <211> 933 <212> DNA <213> Canis familiaris <400> 1929 atgaggaatc acacagagct ccgtgagttt attctactgg gaatacctca gacagcggga

Page 2163

069269_0225_SL.TXT

atggagactg tgctatttgt catcttctca cttatttacc tcttcacctt gctgggcaat 120 ttactcatcc ttacagcagt tgtttcttcc tctacccttc acacccctat gtacttcttc 180 ctgggactcc tatctatttt tgacatgttg tttccatctg taacctgtcc caagatgctg 240 ttctatctct ctggccaaag tcacgccatt tcttacgagg gctgtgttgc acagctcttt 300 ttctaccatt tcctggggtc tactgaaggg tgcctctatt ctgcaatggc atatgaccgc 360 tttgtggcta tctgccaccc cctgaggtat atgctcatca tgagacctgg ggtctgtgtt 420 ggcttggtca tggcagcctg cttggtgggt tgtcttcacg ccaccatcct gacctccttc 480 acctttcagt taacatactc tggctccaac ctggtggact actttttctg tgacattcct 540 gctgtcttac ccctggcctg tgctgacagc tccctggccc agagagtggg ctccactaat 600 gttgggtttc tggctttaat gctctggttc agtgtttgtg tctcctacac gcgcattggg 660 attgccattc tgagaatccg ctcggcagag ggcaggcaga aagctttctc cacctgcagt 720 gcccacctca ctgcaatcct ctgtgcctat ggtcctgtga tcatcatcta tctgcagccc 780 acacccaacc ccttgcttgg ggctatggta cagatattaa ataatattgt gtcacccatg 840 ctgaactcat taatctattc cttaagaaac aaagaagtga aaagttccct aaaaagagtg 900 ttccgccatc tagtatttat ttctctggaa taa 933

<210> 1930 <211> 310 <212> PRT <213> Canis familiaris <400> 1930

Met 1 Arg Asn His Thr Glu Leu Arg Glu Phe Ile Leu Leu Gly Ile Pro 5 10 15 Gln Thr Ala Gly Met Glu Thr Val Leu Phe Val Ile Phe Ser Leu Ile 20 25 30 Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Leu Thr Ala Val Val 35 40 45 Ser Ser Ser Thr Leu His Thr Pro Met Tyr Phe Phe Leu Gly Leu Leu

50 55 60

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Ser 65 Ile Phe Asp Met Leu 70 Phe Pro Ser Val Thr Cys Pro Lys Met 75 Leu 80 Phe Tyr Leu Ser Gly Gln Ser His Ala Ile Ser Tyr Glu Gly Cys Val 85 90 95 Ala Gln Leu Phe Phe Tyr His Phe Leu Gly Ser Thr Glu Gly Cys Leu 100 105 110 Tyr Ser Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu 115 120 125 Arg Tyr Met Leu Ile Met Arg Pro Gly Val Cys Val Gly Leu Val Met 130 135 140 Ala Ala Cys Leu Val Gly Cys Leu His Ala Thr Ile Leu Thr Ser Phe 145 150 155 160 Thr Phe Gln Leu Thr Tyr Ser Gly Ser Asn Leu Val Asp Tyr Phe Phe 165 170 175 Cys Asp Ile Pro Ala Val Leu Pro Leu Ala Cys Ala Asp Ser Ser Leu 180 185 190 Ala Gln Arg Val Gly Ser Thr Asn Val Gly Phe Leu Ala Leu Met Leu 195 200 205 Trp Phe Ser Val Cys Val Ser Tyr Thr Arg Ile Gly Ile Ala Ile Leu 210 215 220 Arg Ile Arg Ser Ala Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ala His Leu Thr Ala Ile Leu Cys Ala Tyr Gly Pro Val Ile Ile Ile 245 250 255 Tyr Leu Gln Pro Thr Pro Asn Pro Leu Leu Gly Ala Met Val Gln Ile 260 265 270

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Leu Asn Asn Ile Val Ser Pro Met 280 Leu Asn Ser Leu Ile Tyr Ser Leu 285 275 Arg Asn Lys Glu Val Lys Ser Ser Leu Lys Arg Val Phe Arg His Leu 290 295 300 Val Phe Ile Ser Leu Glu 305 310

<210> 1931 <211> 936 <212> DNA <213> Canis familiaris <400> 1931

atgagaaatc acacattggt gacagaattc atcctgttgg gaatccctga gacagagggc 60 ctagagactg tcctcttttt cctgttctcc tcgttatact tatgcactct gttgggaaat 120 gtgctcatcc ttacagctat cgtctcttcc tctcggctgc acactcctat gtattttttc 180 ttgggaaatc tttccatgtt cgacctgggt ttctcttcaa caactgttcc caagatgctg 240 ttataccttt cagggcagag tcaaggtatc tcttttcagg gctgcatgtc ccagctcttc 300 ttctatcatt tcctgggctg cactgagtgt ttcttgtaca cagtgatggc ctatgaccgc 360 tttgttgcca tatgttatcc tttgagatac atggtcatca tgaaccacag ggtctgctcc 420 atcttggcca cagggacctg gatgggtggt tgtgttcacg ccattattct aacctccctc 480 actttccagt tgacctactg tgcctctaat gaggtggact actacttctg tgacatacct 540 gcagtcctac ctctagcctg tggtgataca tctctagccc agagggtagg tttcacaaat 600 gttggtcttc tgtctctcat ttgctttttt ctcatccttg tttcctacac tcacattggg 660 atctccatat caaaaatccg ttcggcagaa ggcaggcaga gagccttctc cacttgcagt 720 gcccacatca ctgcaattct ttgtgcttat ggaccagtaa tcatcatcta tctccagccc 780 aatcccagtg ccttgctcgg tgcaataatt cagatattga ataatcttgt aacccctatg 840 ctgaacccac tcatctacag cctgaggaat aaggatgtaa aatcagccct gaggaatgta 900 tttcataaga gaggctttgc tgtggagaat aagtga 936

Page 2166

069269_0225_SL.TXT <210> 1932 <211> 311 <212> PRT <213> Canis familiaris

<400> 1932 Met 1 Arg Asn His Thr Leu 5 Val Thr Glu Phe 10 Ile Leu Leu Gly Ile 15 Pro Glu Thr Glu Gly Leu Glu Thr Val Leu Phe Phe Leu Phe Ser Ser Leu 20 25 30 Tyr Leu Cys Thr Leu Leu Gly Asn Val Leu Ile Leu Thr Ala Ile Val 35 40 45 Ser Ser Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu 50 55 60 Ser Met Phe Asp Leu Gly Phe Ser Ser Thr Thr Val Pro Lys Met Leu 65 70 75 80 Leu Tyr Leu Ser Gly Gln Ser Gln Gly Ile Ser Phe Gln Gly Cys Met 85 90 95 Ser Gln Leu Phe Phe Tyr His Phe Leu Gly Cys Thr Glu Cys Phe Leu 100 105 110 Tyr Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Tyr Pro Leu 115 120 125 Arg Tyr Met Val Ile Met Asn His Arg Val Cys Ser Ile Leu Ala Thr 130 135 140 Gly Thr Trp Met Gly Gly Cys Val His Ala Ile Ile Leu Thr Ser Leu 145 150 155 160 Thr Phe Gln Leu Thr Tyr Cys Ala Ser Asn Glu Val Asp Tyr Tyr Phe 165 170 175 Cys Asp Ile Pro Ala Val Leu Pro Leu Ala Cys Gly Asp Thr Ser Leu

Page 2167

180

Ala Gln Arg 195

Phe Phe Leu 210

Lys Ile Arg 225

Ala His Ile

Tyr Leu Gln

Leu Asn Asn 275

Arg Asn Lys 290

Gly Phe Ala 305

069269_0225_SL.TXT 185 190

Val Gly Phe Thr Asn Val Gly Leu Leu Ser Leu Ile Cys 200 205

Ile Leu Val Ser Tyr Thr His Ile Gly Ile Ser Ile Ser 215 220

Ser Ala Glu Gly Arg Gln Arg Ala Phe Ser Thr Cys Ser 230 235 240

Thr Ala Ile Leu Cys Ala Tyr Gly Pro Val Ile Ile Ile 245 250 255

Pro Asn Pro Ser Ala Leu Leu Gly Ala Ile Ile Gln Ile 260 265 270

Leu Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu 280 285

Asp Val Lys Ser Ala Leu Arg Asn Val Phe His Lys Arg 295 300

Val Glu Asn Lys 310 <210> 1933 <211> 933 <212> DNA <213> Canis <400> 1933 atgaagaatc ctggaaaaca ctgctcattc ctgggaaacc ctctccctag ttttaccact familiaris acactcctgt aaccgagttc ctcctgatgg gaatccctta cacaaaaggg tgctcttcgt cttatttctg gccttctact ttctcactct tctggggaac ttctggccat cctcacttcc tccaacctgc acacccccat gtatttcttc tgtctgtgtt cgatatattt ttcccttcag tgagctcccc caaaatgatg tggggcaaag ccggaccatc tcttacccgg gctgtgcctg tcagctcttc tcctgggctg cactgagtgt ttcctgtaca ccgtgatggc ctatgaccgc Page 2168

120

180

240

300

360

069269_0225_SL.TXT

tttgcggcca tctgtcaccc tctgcagtac acagtcatca tgaatcgcag agtgtgcacc 420 atcatgacgc taggcacctg ggtggggagc tgtctgcatg cagctgtact cacattcctc 480 atctttcact tacccttctg cggccccaat gaggtggaca atttcttctg tgatatccca 540 gtggtgttac ccctggcctg tgcagacacc tctctagctc agacagtgag ttttaccaat 600 gtaggtattg ttgcactcat ctgttttctt cttatcctca cttcttatat tcgcattgtt 660 gtctctgtat tgaaaattag ctcctcagaa ggccggcgaa gagctttttc aacctgcagt 720 gcccacctga cttccatcct gctcttctat ggaccggtgg tcctcattta tctccggcct 780 gcctccagcc cctggttgga ttctgtggtt caggtgttga ataatattgt caccccttcc 840 ctgaatcctt tgatatacac cttgagaaac aaggatgtga agttggctct gaggaaagca 900 ctgatccaag gagtacatac ttgtggggtg taa 933

<210> 1934 <211> 310 <212> PRT <213> Canis familiaris <400> 1934

Met 1 Lys Asn His Thr Pro 5 Val Thr Glu Phe Leu Leu Met Gly Ile Pro 10 15 Tyr Thr Lys Gly Leu Glu Asn Met Leu Phe Val Leu Phe Leu Ala Phe 20 25 30 Tyr Phe Leu Thr Leu Leu Gly Asn Leu Leu Ile Leu Leu Ala Ile Leu 35 40 45 Thr Ser Ser Asn Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu 50 55 60 Ser Val Phe Asp Ile Phe Phe Pro Ser Val Ser Ser Pro Lys Met Met 65 70 75 80 Leu Ser Leu Val Gly Gln Ser Arg Thr Ile Ser Tyr Pro Gly Cys Ala 85 90 95

Page 2169

Cys Gln Leu Phe 100 Phe Tyr His 069269_0225_SL.TXT Phe Leu Gly Cys Thr Glu 105 Cys 110 Phe Leu Tyr Thr Val Met Ala Tyr Asp Arg Phe Ala Ala Ile Cys His Pro Leu 115 120 125 Gln Tyr Thr Val Ile Met Asn Arg Arg Val Cys Thr Ile Met Thr Leu 130 135 140 Gly Thr Trp Val Gly Ser Cys Leu His Ala Ala Val Leu Thr Phe Leu 145 150 155 160 Ile Phe His Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Asn Phe Phe 165 170 175 Cys Asp Ile Pro Val Val Leu Pro Leu Ala Cys Ala Asp Thr Ser Leu 180 185 190 Ala Gln Thr Val Ser Phe Thr Asn Val Gly Ile Val Ala Leu Ile Cys 195 200 205 Phe Leu Leu Ile Leu Thr Ser Tyr Ile Arg Ile Val Val Ser Val Leu 210 215 220 Lys Ile Ser Ser Ser Glu Gly Arg Arg Arg Ala Phe Ser Thr Cys Ser 225 230 235 240 Ala His Leu Thr Ser Ile Leu Leu Phe Tyr Gly Pro Val Val Leu Ile 245 250 255 Tyr Leu Arg Pro Ala Ser Ser Pro Trp Leu Asp Ser Val Val Gln Val 260 265 270 Leu Asn Asn Ile Val Thr Pro Ser Leu Asn Pro Leu Ile Tyr Thr Leu 275 280 285 Arg Asn Lys Asp Val Lys Leu Ala Leu Arg Lys Ala Leu Ile Gln Gly 290 295 300

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Val His Thr Cys Gly Val 305 310 <210> 1935 <211> 933 <212> DNA <213> Canis familiaris <400> 1935

atgcagaact acacttctgt gatggagttc atcctattgg gaattcccaa taccgaaggg 60 ctggagaaca tgctgtttgt cttatttttg gccttctatc tcttcacctt gttgggaaac 120 ctgctcattt tcctcaccat tctggtctcc tccaacctgc acacccccat gtatttcttc 180 ttgggaaacc tgtctgtctt tgatatattt ttcccttctg tgagctcccc caaaatgatg 240 ctctacctaa tggggcaaag ccggaccatc tcataccagg gctgtgcctg ccaactcttc 300 ttttaccact tcctgggtgg cactgagtgt ttcctgtaca ccgtgatggc ctacgaccga 360 tttgtggcta tttgtcaccc tttgcgatac acagtcatca tgaaccgcag ggtgtgcact 420 ggcttgacat tgggcacttg gctgggcggc tgtctccatg gaagtatcct cacctttctg 480 gtctttaagt taccctactg tggctccaat gaggtggaca atttcttctg tgatatccca 540 gtggtgttac ccctggcctg tgcagacacc tctctagctc agacagtgag ttttactaac 600 gtggatgttg tgacgcttac atgctttttc cttatcctta cttcctatgg tcacatcgtc 660 ctttctatat tgaaaatcag cactgcggaa ggcaggcgcc gagctttttc aacctgcagt 720 gcccacctga tgtcaatctt cttgttctat gggccggtga tgctcatcta tctcaggcct 780 gcttccagcc cctggctaga ttctgttatt caagtgttga ataatattgt cactccttct 840 ctcaaccctt tgatttacac cttaagaaac aaggatgtga aattggcttt gaggaaagta 900 ttcactcaaa tggtccacat ttctggggta taa 933

<210> 1936 <211> 310 <212> PRT <213> Canis familiaris <400> 1936

Met Gln Asn Tyr Thr Ser Val Met Glu Phe Ile Leu Leu Gly Ile Pro 1 5 10 15

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Asn Thr Glu Gly Leu 20 Glu Asn Met Leu Phe Val Leu Phe Leu Ala Phe 25 30 Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Phe Leu Thr Ile Leu 35 40 45 Val Ser Ser Asn Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu 50 55 60 Ser Val Phe Asp Ile Phe Phe Pro Ser Val Ser Ser Pro Lys Met Met 65 70 75 80 Leu Tyr Leu Met Gly Gln Ser Arg Thr Ile Ser Tyr Gln Gly Cys Ala 85 90 95 Cys Gln Leu Phe Phe Tyr His Phe Leu Gly Gly Thr Glu Cys Phe Leu 100 105 110 Tyr Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu 115 120 125 Arg Tyr Thr Val Ile Met Asn Arg Arg Val Cys Thr Gly Leu Thr Leu 130 135 140 Gly Thr Trp Leu Gly Gly Cys Leu His Gly Ser Ile Leu Thr Phe Leu 145 150 155 160 Val Phe Lys Leu Pro Tyr Cys Gly Ser Asn Glu Val Asp Asn Phe Phe 165 170 175 Cys Asp Ile Pro Val Val Leu Pro Leu Ala Cys Ala Asp Thr Ser Leu 180 185 190 Ala Gln Thr Val Ser Phe Thr Asn Val Asp Val Val Thr Leu Thr Cys 195 200 205 Phe Phe Leu Ile Leu Thr Ser Tyr Gly His Ile Val Leu Ser Ile Leu 210 215 220

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Lys Ile 225 Ser Thr Ala Glu Gly Arg Arg Arg Ala Phe Ser Thr Cys Ser 230 235 240 Ala His Leu Met Ser Ile Phe Leu Phe Tyr Gly Pro Val Met Leu Ile 245 250 255 Tyr Leu Arg Pro Ala Ser Ser Pro Trp Leu Asp Ser Val Ile Gln Val 260 265 270 Leu Asn Asn Ile Val Thr Pro Ser Leu Asn Pro Leu Ile Tyr Thr Leu 275 280 285 Arg Asn Lys Asp Val Lys Leu Ala Leu Arg Lys Val Phe Thr Gln Met 290 295 300 Val His Ile Ser Gly Val

305 310 <210> 1937 <211> 933 <212> DNA <213> Canis familiaris <400> 1937

atgacaaaca tgagtgtagt gacaatgttc atcctcatgg gccttcccca tgcaccagcc 60 ctggacatcc ccttcttcac aatcttctta gtgatttatg tactcaccgt gatggggaac 120 ctcctcatcc tgctggtgat cagggtggat tctcacctcc acacccccat gtactacttc 180 ctgaccaacc tgtccttcat tgacatgtgg ttctccacag tcactgtgcc caaaatgctg 240 atgaccttgg ggtctccagg aggcaggatg atctcctttc acagctgcat ggcccagctc 300 tactgcttcc acttcctggg cagcaccgag tgtttcctct acacagtcat gtcctatgac 360 cgctacctgg ccatcagtca cccactcagg tacgccagca tgatgagggg gagaacgtgt 420 gccctcctgg ccaccggcac gtggctcagt ggctctctgc actctgctgt ccagaccacg 480 ctgacattcc gtttgcccta ctgtggtccc ggccagatcc agcattactt ctgtgatgcc 540 cctcccatcc tcaggctggc ctgtgcagac acctctgtga acgagatggt gatctttgtc 600 aacattgggg tggtggcctc gggctgcttc ctcctcatag tgttgtccta tgtgtccatc 660

Page 2173

069269_0225_SL.TXT gtctgttcca tcctgaaaga aatccgcacc tcagaggaga ggcatagagc ctctcagacc tgtgcctccc actgcattgt ggtcctttgt ttctttggcc ctggtctttt catttacctg aggccaggct ccagggatgc tgtggatggg gttgtggtct tctacacggt gctgacaccc cttctaatcc ctgtggtgta caccctgagg aacaaggaag tgaagaaagc tgtgctcaag gtgggcagaa agtcagtgtt gggtcaatgt gaa

720

780

840

900

933 <210> 1938 <211> 311 <212> PRT <213> Canis familiaris <400> 1938

Met Thr 1 Asn Met Ser Val Val Thr Met Phe Ile Leu Met Gly Leu 15 Pro 5 10 His Ala Pro Ala Leu Asp Ile Pro Phe Phe Thr Ile Phe Leu Val Ile 20 25 30 Tyr Val Leu Thr Val Met Gly Asn Leu Leu Ile Leu Leu Val Ile Arg 35 40 45 Val Asp Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Thr Asn Leu 50 55 60 Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu 65 70 75 80 Met Thr Leu Gly Ser Pro Gly Gly Arg Met Ile Ser Phe His Ser Cys 85 90 95 Met Ala Gln Leu Tyr Cys Phe His Phe Leu Gly Ser Thr Glu Cys Phe 100 105 110 Leu Tyr Thr Val Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser His Pro 115 120 125 Leu Arg Tyr Ala Ser Met Met Arg Gly Arg Thr Cys Ala Leu Leu Ala 130 135 140

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Thr 145 Gly Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Thr 150 155 160 Leu Thr Phe Arg Leu Pro Tyr Cys Gly Pro Gly Gln Ile Gln His Tyr 165 170 175 Phe Cys Asp Ala Pro Pro Ile Leu Arg Leu Ala Cys Ala Asp Thr Ser 180 185 190 Val Asn Glu Met Val Ile Phe Val Asn Ile Gly Val Val Ala Ser Gly 195 200 205 Cys Phe Leu Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile 210 215 220 Leu Lys Glu Ile Arg Thr Ser Glu Glu Arg His Arg Ala Ser Gln Thr 225 230 235 240 Cys Ala Ser His Cys Ile Val Val Leu Cys Phe Phe Gly Pro Gly Leu 245 250 255 Phe Ile Tyr Leu Arg Pro Gly Ser Arg Asp Ala Val Asp Gly Val Val 260 265 270 Val Phe Tyr Thr Val Leu Thr Pro Leu Leu Ile Pro Val Val Tyr Thr 275 280 285 Leu Arg Asn Lys Glu Val Lys Lys Ala Val Leu Lys Val Gly Arg Lys 290 295 300 Ser Val Leu Gly Gln Cys Glu

305 310 <210> 1939 <211> 936 <212> DNA <213> Canis familiaris <400> 1939

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069269_0225_SL.TXT atgacaaaca ggagcctcgt aacaacattc atcctcatag gccttcccca tgcaccagcc 60 ctggacatcc ccctcttcac aatcttctta gtgatttatg tactcaccgt gatggggaac 120 ctcctcatcc tgctggtgat catggtagat tctcacctcc acacccccat gtactacttc 180 ctgaccaacc tgtccttcat tgacatgtgg ttctccacag tcactgtgcc caaaatgctg 240 atgaccttgg ggtctccagg aggcagaatg atctcctttc acagctgcat ggcccagctc 300 tactgcttcc acttcctggg cagcaccgag tgtttcctct acacagtcat gtcttatgac 360 cgctacctgg ccatcagtca cccactcagg tacgccagca tgatgagggg gagaacgtgt 420 gccctcctgg ccaccagcac gtggctcagt ggctctctgc actctgctgt ccagaccacg 480 ctgacgttcc gtttgcccta ctgtgggccc agccagatcc agcattactt ctgtgatgcc 540 cctcccatcc tcaggctggc ctgtgcagac acctccgtga atgagatagt gatctttgtc 600 aacattgggg tggtggcctc gggctgcttc ctcctcatag tgttgtccta tgtgtccatt 660 gtctgttcca tcctgaagat ccgcacctca gaggggaggc acagagcctt tcagacctgt 720 gcctcccact gcattgtggt cctttgtttc tttgttccct gtgttttcat ctacctgagg 780 ccaggctcca gggatgctgt ggatggggtc gtggcagtct tctacacggt gctgacaccc 840 cttctaaacc ctgtggtgta taccctgagg aacaaggaag tgaagaaagc tctgttgaag 900 cttaaagaca aaataacaca gtctcagagc aaataa 936 <210> 1940 <211> 311 <212> PRT <213> Canis familiaris

<400> 1940 Met 1 Thr Asn Arg Ser Leu Val Thr Thr Phe Ile Leu Ile Gly Leu Pro 5 10 15 His Ala Pro Ala Leu Asp Ile Pro Leu Phe Thr Ile Phe Leu Val Ile 20 25 30 Tyr Val Leu Thr Val Met Gly Asn Leu Leu Ile Leu Leu Val Ile Met 35 40 45 Val Asp Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Thr Asn Leu Page 2176

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50 55 60 Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu 65 70 75 80 Met Thr Leu Gly Ser Pro Gly Gly Arg Met Ile Ser Phe His Ser Cys 85 90 95 Met Ala Gln Leu Tyr Cys Phe His Phe Leu Gly Ser Thr Glu Cys Phe 100 105 110 Leu Tyr Thr Val Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser His Pro 115 120 125 Leu Arg Tyr Ala Ser Met Met Arg Gly Arg Thr Cys Ala Leu Leu Ala 130 135 140 Thr Ser Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Thr 145 150 155 160 Leu Thr Phe Arg Leu Pro Tyr Cys Gly Pro Ser Gln Ile Gln His Tyr 165 170 175 Phe Cys Asp Ala Pro Pro Ile Leu Arg Leu Ala Cys Ala Asp Thr Ser 180 185 190 Val Asn Glu Ile Val Ile Phe Val Asn Ile Gly Val Val Ala Ser Gly 195 200 205 Cys Phe Leu Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile 210 215 220 Leu Lys Ile Arg Thr Ser Glu Gly Arg His Arg Ala Phe Gln Thr Cys 225 230 235 240 Ala Ser His Cys Ile Val Val Leu Cys Phe Phe Val Pro Cys Val Phe 245 250 255 Ile Tyr Leu Arg Pro Gly Ser Arg Asp Ala Val Asp Gly Val Val Ala

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Val Phe Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr 275 280 285 Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Lys Leu Lys Asp Lys 290 295 300 Ile Thr Gln Ser Gln Ser Lys

305 310 <210> 1941 <211> 936 <212> DNA <213> Canis familiaris <400> 1941

atgacaaaca ggagctttgt aactacattc atcctcatgg gccttcccca tgcaccagcc 60 ctggacatcc ccctcttcac aatcttctta gtgatttatg tactcaccgt gatggggaac 120 ctcctcatcc tgctggtgat cagggtggat tctcacctcc acacccccat gtactacttc 180 ctgaccaacc tgtccttcat tgacatgtgg ttctccacag tcactgtgcc caaaatgctg 240 atgaccttgg ggtctccagg aggcaggatg atctcctttc acagctgcat ggctcagctc 300 tactgcttcc acttcctggg cagcaccgag tgtttcctct acacagtcat gtcctatgac 360 cgctacctgg ccatcagtca cccactcagg tacaccagca tgatgagggg gagaacgtgt 420 gccctcctgg ccaccggcac gtggctcagt ggctctctgc actctgctgt ccagaccacg 480 ctgacattcc gtttgcccta ctgtgggccc agccagatcc agcattactt ctgtgatgga 540 cctcccatcc tcaggctggc ctgtgcagac acctccgtga acgagatggt gatctttgtc 600 aacattgggg tggtggcctc gggctgcttc ctcctcatag tgttgtccta tgtgtccatc 660 gtctgttcca tcctgaagat ccgcacctca gaggggaggc atagagcctt tcagacctgc 720 acctcccact gcattgtggt cctttgcttc tttgttccct gtgttttcat ctacctgagg 780 ccaggctcca gggatgctgt ggatggggtc gtggcagtct tctacacggt gctgacaccc 840 cttctaaacc ctgtggtgta caccctgagg aacaaggaag tgaagaaagc tctgttgaag 900 cttaaagaca aaataacaca gtcccagagc aaataa 936

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069269_0225_SL.TXT <210> 1942 <211> 311 <212> PRT <213> Canis familiaris

<400> 1942 Met 1 Thr Asn Arg Ser 5 Phe Val Thr Thr Phe Ile Leu Met Gly Leu Pro 10 15 His Ala Pro Ala Leu Asp Ile Pro Leu Phe Thr Ile Phe Leu Val Ile 20 25 30 Tyr Val Leu Thr Val Met Gly Asn Leu Leu Ile Leu Leu Val Ile Arg 35 40 45 Val Asp Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Thr Asn Leu 50 55 60 Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu 65 70 75 80 Met Thr Leu Gly Ser Pro Gly Gly Arg Met Ile Ser Phe His Ser Cys 85 90 95 Met Ala Gln Leu Tyr Cys Phe His Phe Leu Gly Ser Thr Glu Cys Phe 100 105 110 Leu Tyr Thr Val Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser His Pro 115 120 125 Leu Arg Tyr Thr Ser Met Met Arg Gly Arg Thr Cys Ala Leu Leu Ala 130 135 140 Thr Gly Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Thr 145 150 155 160 Leu Thr Phe Arg Leu Pro Tyr Cys Gly Pro Ser Gln Ile Gln His Tyr 165 170 175

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Phe Cys Asp Gly Pro Pro Ile Leu Arg Leu Ala Cys Ala Asp Thr Ser 180 185 190 Val Asn Glu Met Val Ile Phe Val Asn Ile Gly Val Val Ala Ser Gly 195 200 205 Cys Phe Leu Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile 210 215 220 Leu Lys Ile Arg Thr Ser Glu Gly Arg His Arg Ala Phe Gln Thr Cys 225 230 235 240 Thr Ser His Cys Ile Val Val Leu Cys Phe Phe Val Pro Cys Val Phe 245 250 255 Ile Tyr Leu Arg Pro Gly Ser Arg Asp Ala Val Asp Gly Val Val Ala 260 265 270 Val Phe Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr 275 280 285 Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Lys Leu Lys Asp Lys 290 295 300 Ile Thr Gln Ser Gln Ser Lys 305 310

<210> 1943 <211> 936 <212> DNA <213> Canis familiaris <400> 1943 atgacaaaca tgagctttgt aagtacattc atcctcatgg gcattcccca tgcaccagcc ctggacatcc ccctcttcac aatcttctta gtgatttatg tactcaccat gatggggaac ctcctcatcc tgctggtgat cagggtggat tctcacctcc acacccccat gtactacttc ctgaccaacc tgtccttcat tgacatgtgg ttctccacag tcactgtgcc caaaatgctg atgaccttcg ggtctccagg aggcaggatg atctcctttc acagctgcat ggcccagctc

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tactgcttcc acttcctggg cagcaccgag tgtttcctct acacagtcat gtcctatgac 360 cgctacctgg ccatcagtca cccactcagg tatgccagca tgatgagggg gagaacgtgt 420 gccctcctgg ccaccagcac gtggctcagt ggctctctgc actctgctgt ccagaccacg 480 ctgacgttcc gtttgcccta ctgtgggccc agccagatcc agcattactt ctgtgatgcc 540 cctcccatcc tcaggctggc ctgtgcagac acctccgtga acgagatggt gatctttgtc 600 aacatcgggg tggtggcctc gggctgcttc ctcctcatag tgttgtccta cgtgtccatc 660 gtctgttcca tcctgaagat ccgcacctca gaggggaggc acagagcctt tcagacctgt 720 gcctcccact gcattgtggt cctttgtttc tttggccctg gtcttttcat ctacctgagg 780 ccaggctcca gggatgctgt ggatggtgtc gtggcagtct tctacacggt gctgacaccc 840 cttctaaacc ctgtggtgta caccctgagg aacaaggaag tgaagaaagc tctgctcaac 900 gtgggcagta agtcaatatt cacccaatgt aaataa 936

<210> 1944 <211> 311 <212> PRT <213> Canis familiaris <400> 1944

Met Thr Asn Met Ser Phe Val Ser Thr Phe Ile Leu Met Gly Ile Pro 1 5 10 15 His Ala Pro Ala Leu Asp Ile Pro Leu Phe Thr Ile Phe Leu Val Ile 20 25 30 Tyr Val Leu Thr Met Met Gly Asn Leu Leu Ile Leu Leu Val Ile Arg 35 40 45 Val Asp Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Thr Asn Leu 50 55 60 Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu 65 70 75 80 Met Thr Phe Gly Ser Pro Gly Gly Arg Met Ile Ser Phe His Ser Cys 85 90 95

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Met Ala Gln Leu 100 Tyr Cys Phe His Phe Leu Gly Ser Thr Glu Cys Phe 105 110 Leu Tyr Thr Val Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser His Pro 115 120 125 Leu Arg Tyr Ala Ser Met Met Arg Gly Arg Thr Cys Ala Leu Leu Ala 130 135 140 Thr Ser Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Thr 145 150 155 160 Leu Thr Phe Arg Leu Pro Tyr Cys Gly Pro Ser Gln Ile Gln His Tyr 165 170 175 Phe Cys Asp Ala Pro Pro Ile Leu Arg Leu Ala Cys Ala Asp Thr Ser 180 185 190 Val Asn Glu Met Val Ile Phe Val Asn Ile Gly Val Val Ala Ser Gly 195 200 205 Cys Phe Leu Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile 210 215 220 Leu Lys Ile Arg Thr Ser Glu Gly Arg His Arg Ala Phe Gln Thr Cys 225 230 235 240 Ala Ser His Cys Ile Val Val Leu Cys Phe Phe Gly Pro Gly Leu Phe 245 250 255 Ile Tyr Leu Arg Pro Gly Ser Arg Asp Ala Val Asp Gly Val Val Ala 260 265 270 Val Phe Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr 275 280 285 Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Asn Val Gly Ser Lys 290 295 300

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Ser Ile Phe Thr Gln Cys Lys 305 310 <210> 1945 <211> 936 <212> DNA <213> Canis familiaris <400> 1945

atgcacagtg gaaaccagac ttctgtgtcc catttcattt tggtgggcct gcaccacccg 60 ccacagctgg gggtgccact cttcctggct ttccttgtca tctatgccct cactgtctct 120 ggcaatgggc tcatcatcct caccgtcttg gtggacaccc ggctccaccg ccccatgtac 180 tggttcctgt gtcacctctc tttcttggac atgaccattt cttctgccat tgtccccaag 240 atgctagctg gctttctcca ggatagcagg gttatctcct ttggaggctg tgtaatccaa 300 cttttttctt tccatttcct gggctgtact gaatgcttcc tttacacact tatggcttat 360 gatcgtttcc tggccatttg taagccttta cattatgcca ctattatgac ccgtaacatc 420 tgtaacttcc tggctttggg tacctggctg ggaggcaccc tccactcact tttccaaacc 480 agcttcatat tccgcctgcc tttctgtggc ccaaaccgag tagactactt cttctgtgac 540 attcctgcca tgctgcgtct agcctgtgct gacaccacca tcaatgagct ggtcaccttt 600 gtagatattg gatttctggc cctcacctgc tttatgctta tccttacttc ctatggttat 660 atagtggctg ccattctgcg aatccagtca gttgatgggc gtcgcaatgc cttctccacc 720 tgtgctgccc acctgaccgt tgtcattgtt tactatgtgc cctgcacctt catttacctc 780 cgtcctggct ctcaggaacc tctggatgga gtggttgctg tcttctacac tgtcatcact 840 cccttgctta accccatcat ctacacactc cgcaacaaag agatgaaagc agcactgtgg 900 aggctgggag gccgcaagga tgtgcagcct cactga 936

<210> 1946 <211> 311 <212> PRT <213> Canis familiaris <400> 1946

Met His Ser Gly Asn Gln Thr Ser Val Ser His Phe Ile Leu Val Gly 1 5 10 15

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Leu His His Pro 20 Pro Gln Leu Gly Val Pro Leu Phe Leu Ala Phe Leu 25 30 Val Ile Tyr Ala Leu Thr Val Ser Gly Asn Gly Leu Ile Ile Leu Thr 35 40 45 Val Leu Val Asp Thr Arg Leu His Arg Pro Met Tyr Trp Phe Leu Cys 50 55 60 His Leu Ser Phe Leu Asp Met Thr Ile Ser Ser Ala Ile Val Pro Lys 65 70 75 80 Met Leu Ala Gly Phe Leu Gln Asp Ser Arg Val Ile Ser Phe Gly Gly 85 90 95 Cys Val Ile Gln Leu Phe Ser Phe His Phe Leu Gly Cys Thr Glu Cys 100 105 110 Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Phe Leu Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Ala Thr Ile Met Thr Arg Asn Ile Cys Asn Phe Leu 130 135 140 Ala Leu Gly Thr Trp Leu Gly Gly Thr Leu His Ser Leu Phe Gln Thr 145 150 155 160 Ser Phe Ile Phe Arg Leu Pro Phe Cys Gly Pro Asn Arg Val Asp Tyr 165 170 175 Phe Phe Cys Asp Ile Pro Ala Met Leu Arg Leu Ala Cys Ala Asp Thr 180 185 190 Thr Ile Asn Glu Leu Val Thr Phe Val Asp Ile Gly Phe Leu Ala Leu 195 200 205 Thr Cys Phe Met Leu Ile Leu Thr Ser Tyr Gly Tyr Ile Val Ala Ala 210 215 220

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Ile Leu 225 Arg Ile Gln Ser Val Asp Gly Arg Arg Asn Ala Phe Ser Thr 230 235 240 Cys Ala Ala His Leu Thr Val Val Ile Val Tyr Tyr Val Pro Cys Thr 245 250 255 Phe Ile Tyr Leu Arg Pro Gly Ser Gln Glu Pro Leu Asp Gly Val Val 260 265 270 Ala Val Phe Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Ile Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Glu Met Lys Ala Ala Leu Trp Arg Leu Gly Gly 290 295 300 Arg Lys Asp Val Gln Pro His

305 310 <210> 1947 <211> 963 <212> DNA <213> Canis familiaris <400> 1947

atggagacgg aggaccccaa ccagactgtg gtgagccact tcttcctgga ggggctgatg 60 tacacagctg aacaacctag cctcttcttc ctcctcttcc tcctcaccta cagcatcacc 120 ttgactggga atctcctcat cctcctgact gtgggctctg atcctcacct ctgctcccct 180 atgtaccact tcctggggca cctctccttc ctggatgcct gtttgtctac agtgacggtg 240 cccaaggtca tggcaggcct cctgaccgtg gatgggaagg tgatctcctt ggagggctgt 300 gctctacagc tttactgctt ccatctcctg gccagcactg agtgcttcct atacacggtc 360 atggcctacg accgctacct agctatctgc caacccctgc gctacccagt ggccatgaac 420 agccggatgt gtgtggggct ggctggcacc acctgggccg taggtgctgt gcattcggcg 480 atccacacct ccctcacctt ccacctgccc tactgcggtc ctcaccacat tgcctacttc 540 ttctgcgaca tccccccggt gctgaagctg gcctgcgccg acacctccgt taatgagctt 600

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gtcatgcttg ccaacattgg cgtcgtggcc gcaggttgct tgatcctcat cgtcgtatcc 660 tatgtcttca tcgtggcggc ggtgctgcgg atccgcaccg cccggggccg gcggagggcc 720 ttctccacct gcacctctca cctcaccgtg gtgctgctgt actacgtgcc acctgtctgc 780 atctacctgc agcctcgctc cgggggggca ggagcggggg tccctgcggt cttctacaca 840 atcgtcactc ccatgctcaa ccctttcatc tacactctgc gcaacaagga ggtcaagcgg 900 gctctgcaaa gacttttgag ccgaggcccg cgggagtccc cgtcaggcag cccgcccccc 960

tga 963 <210> 1948 <211> 320 <212> PRT <213> Canis familiaris <400> 1948

Met Glu Thr Glu Asp Pro Asn Gln Thr Val Val Ser His Phe Phe Leu 1 5 10 15 Glu Gly Leu Met Tyr Thr Ala Glu Gln Pro Ser Leu Phe Phe Leu Leu 20 25 30 Phe Leu Leu Thr Tyr Ser Ile Thr Leu Thr Gly Asn Leu Leu Ile Leu 35 40 45 Leu Thr Val Gly Ser Asp Pro His Leu Cys Ser Pro Met Tyr His Phe 50 55 60 Leu Gly His Leu Ser Phe Leu Asp Ala Cys Leu Ser Thr Val Thr Val 65 70 75 80 Pro Lys Val Met Ala Gly Leu Leu Thr Val Asp Gly Lys Val Ile Ser 85 90 95 Leu Glu Gly Cys Ala Leu Gln Leu Tyr Cys Phe His Leu Leu Ala Ser 100 105 110 Thr Glu Cys Phe Leu Tyr Thr Val Met Ala Tyr Asp Arg Tyr Leu Ala 115 120 125

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Ile Cys Gln Pro Leu Arg Tyr Pro 135 Val Ala Met Asn 140 Ser Arg Met Cys 130 Val Gly Leu Ala Gly Thr Thr Trp Ala Val Gly Ala Val His Ser Ala 145 150 155 160 Ile His Thr Ser Leu Thr Phe His Leu Pro Tyr Cys Gly Pro His His 165 170 175 Ile Ala Tyr Phe Phe Cys Asp Ile Pro Pro Val Leu Lys Leu Ala Cys 180 185 190 Ala Asp Thr Ser Val Asn Glu Leu Val Met Leu Ala Asn Ile Gly Val 195 200 205 Val Ala Ala Gly Cys Leu Ile Leu Ile Val Val Ser Tyr Val Phe Ile 210 215 220 Val Ala Ala Val Leu Arg Ile Arg Thr Ala Arg Gly Arg Arg Arg Ala 225 230 235 240 Phe Ser Thr Cys Thr Ser His Leu Thr Val Val Leu Leu Tyr Tyr Val 245 250 255 Pro Pro Val Cys Ile Tyr Leu Gln Pro Arg Ser Gly Gly Ala Gly Ala 260 265 270 Gly Val Pro Ala Val Phe Tyr Thr Ile Val Thr Pro Met Leu Asn Pro 275 280 285 Phe Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Arg Ala Leu Gln Arg 290 295 300 Leu Leu Ser Arg Gly Pro Arg Glu Ser Pro Ser Gly Ser Pro Pro Pro 305 310 315 320

<210> 1949 <211> 936 <212> DNA

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069269_0225_SL.TXT <213> Canis familiaris <400> 1949 atggctgcag ataacgcctc ctctgtgaca gagtttatcc tggcaggctt aacagatgag 60 ccggaactcc agatgcccct cttcttcctg ttcctaggtt tttatgtggt caccgtggtg 120 gggaacctgg gcctcataac cctgattggg ctgaattctc accttcatat tcccatgtac 180 ttcttcctcc tcaacttgtc tttcattgat tttagttatt ccactactct cactcctaaa 240 atgttaatgg gttttgtctc aaagagaaac atcatttcct atgcggggtg tgtgactcag 300 ttttttttct tctgtttctt tgtcttttct gaatcctata tcttgtcagc gatggcatat 360 gaccgctatg tcgccatctg taaaccactg ctgtacacgg tcaccatgtc tcctcaggtg 420 tgtttactcc tcatgttggg tgtttatggg atgggggtgt ttggggctgt gacccatatg 480 ggaaacatca tgtttataac cttttgtgct gacaaccttg tcaatcacta tatgtgtgat 540 atcattcccc tccttgagct ctcctgcaac agctcttaca taaatttgct ggtggtcttc 600 attgttgtga ccattggcat tggggtgcct attgtgacca ttttcatctc ttatggtttc 660 attctttcta gtattctcca cattagttca actgagggca gatccaaagc cttcagtacc 720 tgcagttccc atataattgt ggtatctctt ttctttggat caggagcttt tatgtatctc 780 aaaccacctt ctattttacc ccttgaccag gggaaagtgt cttccatatt ctatactgct 840 gtggtaccca tgttcaaccc gctgatttat agtctgagga ataaggatgt caaaattgcc 900 ctgaagaaaa cattaggcag aaaactcttc tcttga 936 <210> 1950 <211> 311 <212> PRT <213> Canis familiaris

<400> 1950 Ala Ser Ser Val Thr Glu Phe Ile Leu Ala Gly Met 1 Ala Ala Asp Asn 5 10 15 Leu Thr Asp Glu Pro Glu Leu Gln Met Pro Leu Phe Phe Leu Phe Leu 20 25 30 Gly Phe Tyr Val Val Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45

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Ile Gly 50 Leu Asn Ser His Leu His Ile Pro Met Tyr Phe Phe Leu Leu 55 60 Asn Leu Ser Phe Ile Asp Phe Ser Tyr Ser Thr Thr Leu Thr Pro Lys 65 70 75 80 Met Leu Met Gly Phe Val Ser Lys Arg Asn Ile Ile Ser Tyr Ala Gly 85 90 95 Cys Val Thr Gln Phe Phe Phe Phe Cys Phe Phe Val Phe Ser Glu Ser 100 105 110 Tyr Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Thr Val Thr Met Ser Pro Gln Val Cys Leu Leu Leu 130 135 140 Met Leu Gly Val Tyr Gly Met Gly Val Phe Gly Ala Val Thr His Met 145 150 155 160 Gly Asn Ile Met Phe Ile Thr Phe Cys Ala Asp Asn Leu Val Asn His 165 170 175 Tyr Met Cys Asp Ile Ile Pro Leu Leu Glu Leu Ser Cys Asn Ser Ser 180 185 190 Tyr Ile Asn Leu Leu Val Val Phe Ile Val Val Thr Ile Gly Ile Gly 195 200 205 Val Pro Ile Val Thr Ile Phe Ile Ser Tyr Gly Phe Ile Leu Ser Ser 210 215 220 Ile Leu His Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ile Val Val Ser Leu Phe Phe Gly Ser Gly Ala 245 250 255

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Phe Met Tyr Leu Lys Pro Pro Ser Ile Leu Pro Leu Asp Gln Gly Lys 260 265 270 Val Ser Ser Ile Phe Tyr Thr Ala Val Val Pro Met Phe Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ile Ala Leu Lys Lys Thr 290 295 300 Leu Gly Arg Lys Leu Phe Ser

305 310 <210> 1951 <211> 933 <212> DNA <213> Canis familiaris <400> 1951 atggccatag gaaatgactc ttcagtgacc gagtttatcc tgctgggttt aacacaacag ccagaactcc agctgcctct cttcttcatt ttcttaggat tctatgtggt caccatggtg gggaacatgg gcttgatttt tctgattggt ctgaaccctc acctgcacac tcccatgtac tactttctct tcaacctttc cttcattgat ttctgctact cgtctgtcat aatccctaga atgctgatga gttttgtaaa ggagaacatc atctcttatg cagagtgcat gacacagctc tgtttcttct ctttctttgt tatcgatgag tgctatgttt tgacatcaat ggcttatgac cggtatgtgg ccatctgtaa gcccctgctc tacaaggtca ccatgtccca tcaggtctgc ctcatgctga tggtgggaac atatgtgatg gggtttgtgg gtgccattgc ccacaccggt tgtatgctga gactcagctt ctgtgatggc aacatcgtca atcattacat gtgtgacata cctcctcttc tccagctctc ttgcacaagc acgtatatca atgaggttat ggttttcatt gtggtgggca tcaatgtaat agtgcccagt ctcactatct ccatttctta caccttgatc ctctccaaca tattccatat ccgttctaca gagggcaggt ccaaagcctt cagtacctgt agctctcaca tagttactgt ttctctcttc tttggagcat cggcattcat gtaccttaag ccctctcctg ctgggtctct ggatcgagat aaagtatcca cagtttttta taccatcgtg

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933

069269_0225_SL.TXT gggccaatga tgaatccttt tatttacagt ctaaggaaca aagatgttaa aattgcactg agtaagactt tgaagaaaag ggtgttctca taa <210> 1952 <211> 310 <212> PRT <213> Canis familiaris <400> 1952

Met Ala Ile Gly Asn Asp Ser Ser Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Thr Gln Gln Pro Glu Leu Gln Leu Pro Leu Phe Phe Ile Phe Leu 20 25 30 Gly Phe Tyr Val Val Thr Met Val Gly Asn Met Gly Leu Ile Phe Leu 35 40 45 Ile Gly Leu Asn Pro His Leu His Thr Pro Met Tyr Tyr Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Ile Ile Pro Arg 65 70 75 80 Met Leu Met Ser Phe Val Lys Glu Asn Ile Ile Ser Tyr Ala Glu Cys 85 90 95 Met Thr Gln Leu Cys Phe Phe Ser Phe Phe Val Ile Asp Glu Cys Tyr 100 105 110 Val Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro 115 120 125 Leu Leu Tyr Lys Val Thr Met Ser His Gln Val Cys Leu Met Leu Met 130 135 140 Val Gly Thr Tyr Val Met Gly Phe Val Gly Ala Ile Ala His Thr Gly 145 150 155 160 Cys Met Leu Arg Leu Ser Phe Cys Asp Gly Asn Ile Val Asn His Tyr

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165 170 175 Met Cys Asp Ile Pro Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr Tyr 180 185 190 Ile Asn Glu Val Met Val Phe Ile Val Val Gly Ile Asn Val Ile Val 195 200 205 Pro Ser Leu Thr Ile Ser Ile Ser Tyr Thr Leu Ile Leu Ser Asn Ile 210 215 220 Phe His Ile Arg Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Ile Val Thr Val Ser Leu Phe Phe Gly Ala Ser Ala Phe 245 250 255 Met Tyr Leu Lys Pro Ser Pro Ala Gly Ser Leu Asp Arg Asp Lys Val 260 265 270 Ser Thr Val Phe Tyr Thr Ile Val Gly Pro Met Met Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Ile Ala Leu Ser Lys Thr Leu 290 295 300 Lys Lys Arg Val Phe Ser 305 310

<210> 1953 <211> 900 <212> DNA <213> Canis familiaris <400> 1953 ctggaaaact ggactcaggt gacagagttt gtccttttgg gtttccccag aagccacatc ctacagtctc tgctgttcct ggggttgatg gtgacctaca ttgtaacggc ctcaggcaac ctactcatta ttgggctcag ctgggtgagc agacgcctac acacacagat gtacttcttc ctgaggaacc tgtcctttct ggagctgttg cttgtgtctg ttgtggttcc ataaatgctt

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gtcatcattc tcacagggga tcactccatc tcatttgcca gttgcatcct ccaatcctac 300 ctctacttcc tccttggcac caccgacttc ttcctcttag ctgtcatgtc tctggatcgt 360 tacttggcaa tctgccgccc cctccactat gagactctga tgagcggtcg tgtctgttcc 420 caattagttc tggcctcctg gctagctgga ttcctctggg tgctctgtcc caccatcctc 480 atggccagcc tacctttctg tggcccccgt ggtattgacc actttttctg tgacagctgg 540 cctttgctga ggctctcttg tggagacacc cgcctactgg agctggtggc atttgtgctc 600 tccacgacag tgttactggg gtcactggcg gtgaccttgg tttcctatgc ctgcattctt 660 gccacagttt tcagggcccc cacagctgcc gagcggaaga aggcattctc cacttgtgtc 720 tcacatctta ctgtggtggt catcgtctat ggcagctcca tttttctcta catccgtgtg 780 tcggaggctc agtcctcact gctcaacaaa ggtgcctcag tcctgagctg tatcatcaca 840 cccctcctga acccattcat cttcagtctc cgcaatgata aggtgaagca ggccctgaga 900

<210> 1954 <211> 222 <212> PRT <213> Canis familiaris

<400> 1954 Leu Thr Gly Asp His Ser Ile Ser Phe Ala Ser Met 1 Leu Val Ile Ile 5 10 15 Cys Ile Leu Gln Ser Tyr Leu Tyr Phe Leu Leu Gly Thr Thr Asp Phe 20 25 30 Phe Leu Leu Ala Val Met Ser Leu Asp Arg Tyr Leu Ala Ile Cys Arg 35 40 45 Pro Leu His Tyr Glu Thr Leu Met Ser Gly Arg Val Cys Ser Gln Leu 50 55 60 Val Leu Ala Ser Trp Leu Ala Gly Phe Leu Trp Val Leu Cys Pro Thr 65 70 75 80 Ile Leu Met Ala Ser Leu Pro Phe Cys Gly Pro Arg Gly Ile Asp His 85 90 95

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Phe Phe Cys Asp Ser Trp Pro Leu Leu Arg Leu Ser Cys Gly Asp Thr 100 105 110 Arg Leu Leu Glu Leu Val Ala Phe Val Leu Ser Thr Thr Val Leu Leu 115 120 125 Gly Ser Leu Ala Val Thr Leu Val Ser Tyr Ala Cys Ile Leu Ala Thr 130 135 140 Val Phe Arg Ala Pro Thr Ala Ala Glu Arg Lys Lys Ala Phe Ser Thr 145 150 155 160 Cys Val Ser His Leu Thr Val Val Val Ile Val Tyr Gly Ser Ser Ile 165 170 175 Phe Leu Tyr Ile Arg Val Ser Glu Ala Gln Ser Ser Leu Leu Asn Lys 180 185 190 Gly Ala Ser Val Leu Ser Cys Ile Ile Thr Pro Leu Leu Asn Pro Phe 195 200 205 Ile Phe Ser Leu Arg Asn Asp Lys Val Lys Gln Ala Leu Arg 210 215 220

<210> 1955 <211> 945 <212> DNA <213> Canis familiaris <400> 1955

atgaatccaa caaatcatac ccaggtgaca ggctttgtcc tcctggggct ctctcaggta 60 tgggagctcc ggttcttctt cttcattgtc ttctcagctg tgtatcttat gactgtaatg 120 ggaaatctcc ttattgtggc catagtgacc tctgacccac gcctccacac aaccatgtat 180 tttctcttag gcaatctttc tttcctagac ttttgctact ctaccatcac ggcacccagg 240 atgctggttg acttgctctc aggcaacccc atcatttcct ttggtagctg cctgactcag 300 ctctttttct tccatttcat tggaggcatc aagatcttcc tgctgactgt gatggcgttt 360

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gaccgctata ttgccatctc ccagcccttg cgctacagga ttattatgaa tagaacagtc 420 tgtgggctcc tcgtggtagc ctcctgggtg gggggcttca tccactccat tgtacaggtt 480 ggactgacta tccagctgcc attctgtggg cctgacaggc tggacaactt ttactgtgat 540 gtgcctcagc tgatcaaatt ggcctgcaca gatacctttg tcttagagct tctgatggtg 600 tctaacaatg gcctggtgac cctgatgtgt tttctggtgc tcctgggatc ctacacggca 660 ctgctggtca tgctccgagg ccactccagg gagggccgca gcaaagccct atccacttgt 720 gcttctcata ttgccgtagt gaccttaatc tttgtgcctt gtgtctacat ctatgcaagg 780 ccatttcgca ccttccctat ggacaaggtg gtctctgtgc tgtacacaat ggtcactccc 840 atgctgaatc ctgccatcta taccctgaga aacaaggaag cgatcatggc catgaagaag 900 ctgtggagaa ggcaaaaaga ccttctgggt cccctggagc actga 945 <210> 1956 <211> 314 <212> PRT <213> Canis familiaris <400> 1956 Met Asn Pro i Thr Asn His Thr Gln Val Thr Gly Phe Val Leu Leu Gly 1 5 10 15 Leu Ser Gln Val Trp Glu Leu Arg Phe Phe Phe Phe Ile Val Phe Ser 20 25 30 Ala Val Tyr Leu Met Thr Val Met Gly Asn Leu Leu Ile Val Ala Ile 35 40 45 Val Thr Ser Asp Pro Arg Leu His Thr Thr Met Tyr Phe Leu Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Phe Cys Tyr Ser Thr Ile Thr Ala Pro Arg 65 70 75 80 Met Leu Val Asp Leu Leu Ser Gly Asn Pro Ile Ile Ser Phe Gly Ser 85 90 95 Cys Leu Thr Gln Leu Phe Phe Phe His Phe Ile Gly Gly Ile Lys Ile

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100

069269_0225_SL.TXT 105 110

Phe Leu Leu Thr Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Ser Gln 115 120 125 Pro Leu Arg Tyr Arg Ile Ile Met Asn Arg Thr Val Cys Gly Leu Leu 130 135 140 Val Val Ala Ser Trp Val Gly Gly Phe Ile His Ser Ile Val Gln Val 145 150 155 160 Gly Leu Thr Ile Gln Leu Pro Phe Cys Gly Pro Asp Arg Leu Asp Asn 165 170 175 Phe Tyr Cys Asp Val Pro Gln Leu Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Val Leu Glu Leu Leu Met Val Ser Asn Asn Gly Leu Val Thr Leu 195 200 205 Met Cys Phe Leu Val Leu Leu Gly Ser Tyr Thr Ala Leu Leu Val Met 210 215 220 Leu Arg Gly His Ser Arg Glu Gly Arg Ser Lys Ala Leu Ser Thr Cys 225 230 235 240 Ala Ser His Ile Ala Val Val Thr Leu Ile Phe Val Pro Cys Val Tyr 245 250 255 Ile Tyr Ala Arg Pro Phe Arg Thr Phe Pro Met Asp Lys Val Val Ser 260 265 270 Val Leu Tyr Thr Met Val Thr Pro Met Leu Asn Pro Ala Ile Tyr Thr 275 280 285 Leu Arg Asn Lys Glu Ala Ile Met Ala Met Lys Lys Leu Trp Arg Arg 290 295 300

Gln Lys Asp Leu Leu Gly Pro Leu Glu His

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069269_0225_SL.TXT <210> 1957 <211> 936 <212> DNA <213> Canis familiaris <400> 1957

305

310

atgggcctaa gaaatcaatc tgcagtgact gggtttcttc tttcaggact aaccgaccaa 60 cctgagcttc agctgcctct tttctgcctc ttctcaggga tttatgcagt tacagtggcg 120 ggaaatctcg gaatgatctc aataattggg ttgagttctc aacttcacac ccccatgtac 180 catttcctca gtagtttgtc ttttttagat gtatgctatt cttctgttat tacccccaga 240 atgttggcag actttttatg caacgataaa gccatctcct attctggttg catgactcag 300 cttttttttt tttgcatttt tgtcatttct gagtgctaca tgttagctgc catggcctat 360 gatcgctatg tcgccatctg cagccccctg ctgtaccatg tcatcatgtc tcctcgggct 420 tgttctctgc tggtagctgc tggcttctca gtaggcttga ttgatgctat gatccatgga 480 ggttgtatat taaggctgac tttctgtggc ccaaacatca ttaaacatta tttctgtgac 540 atcattccac ttattcaact ctcttgttca agcacttata ttgatgagct tttgattttt 600 gtcattggcg gatttaacat ggtagccacc agcctgacga tcatcatttc ttatggtttc 660 atcctctcca aaatcctcca catccactct atgcagggca ggtccaaagc cttcagcacc 720 tgcagctccc acttgacagc tgttctaata ttttatggga ctctcatgtc catgtatctc 780 aaacctgctt ccagcaggtc actcatccag gagaaagtgt cctcggtatt ttataccact 840 gtgattccca tgttgaatcc cttgatatac agtctgagga ataaggaagt aaaaaatgca 900 ctcatgaaac tcttaaaaag aaaagtatct ttataa 936

<210> 1958 <211> 311 <212> PRT <213> Canis familiaris <400> 1958

Met Gly Leu Arg Asn Gln Ser Ala Val Thr Gly Phe Leu Leu Ser Gly 1 5 10 15

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Leu Thr Asp Gln Pro Glu 20 Leu Gln Leu Pro Leu 25 Phe Cys Leu 30 Phe Ser Gly Ile Tyr Ala Val Thr Val Ala Gly Asn Leu Gly Met Ile Ser Ile 35 40 45 Ile Gly Leu Ser Ser Gln Leu His Thr Pro Met Tyr His Phe Leu Ser 50 55 60 Ser Leu Ser Phe Leu Asp Val Cys Tyr Ser Ser Val Ile Thr Pro Arg 65 70 75 80 Met Leu Ala Asp Phe Leu Cys Asn Asp Lys Ala Ile Ser Tyr Ser Gly 85 90 95 Cys Met Thr Gln Leu Phe Phe Phe Cys Ile Phe Val Ile Ser Glu Cys 100 105 110 Tyr Met Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr His Val Ile Met Ser Pro Arg Ala Cys Ser Leu Leu 130 135 140 Val Ala Ala Gly Phe Ser Val Gly Leu Ile Asp Ala Met Ile His Gly 145 150 155 160 Gly Cys Ile Leu Arg Leu Thr Phe Cys Gly Pro Asn Ile Ile Lys His 165 170 175 Tyr Phe Cys Asp Ile Ile Pro Leu Ile Gln Leu Ser Cys Ser Ser Thr 180 185 190 Tyr Ile Asp Glu Leu Leu Ile Phe Val Ile Gly Gly Phe Asn Met Val 195 200 205 Ala Thr Ser Leu Thr Ile Ile Ile Ser Tyr Gly Phe Ile Leu Ser Lys 210 215 220

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Ile 225 Leu His Ile His Ser Met Gln Gly Arg Ser Lys Ala Phe Ser Thr 230 235 240 Cys Ser Ser His Leu Thr Ala Val Leu Ile Phe Tyr Gly Thr Leu Met 245 250 255 Ser Met Tyr Leu Lys Pro Ala Ser Ser Arg Ser Leu Ile Gln Glu Lys 260 265 270 Val Ser Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Leu Met Lys Leu 290 295 300 Leu Lys Arg Lys Val Ser Leu 305 310

<210> 1959 <211> 948 <212> DNA <213> Canis familiaris <400> 1959

atggctatga gaaaccagag tactttgact gaatttacgt tggtctcctt tcctgtcatt 60 caagagcttc aaatcttgct gtttgtcatt ctcctgatgg tttatatact taccataaca 120 ggaaacattg tcatcatttc cttaatatgg actgataatc gtctccaaac accaatgtat 180 ttcttcctta gtaatctgtc atttttggac attttgttca caaccactat tgccccaaag 240 ttgctagctt gtctcttaga aaagaagaaa acgatatcct ttgctgggtg catcactcaa 300 atttatttct acttctttct ggggacagtg gagtttatcc tcctggcagt gatgtccttt 360 gaccgctacg tggccatctg taaccctctg cgctacacca tcattatgaa cagcagggtt 420 tgtctcctgc tggttctggg ctgctgggtg ggagccttcc tctcagtgct gtgcccaact 480 attgtggtct ccagactgcc ttactgcact aaagaaatta gtcatttctt ctgtgacatt 540 gcccctttac tgcaggtggc ctgcatagac actcatttca ttgagatgat aaacttcctc 600 ttgtcttcct ttgtcctcct gacctcactg gtatttacca tcgtgtccta cacctacatc 660

Page 2199

069269_0225_SL.TXT atctctacca tcctgcgcat cccctcagcc caaggacgtc agaaggcctt ttccacctgt gcttctcaca tcacggttgt gtccattgcc tatgggagca acattttcat gtacatgagg cccagccaga gtcattcact ggagtttgac aaggtgacag ctgtccttac cacaatggta acccctcttc tgaacccctt catttacagc ttaaggaatg aaaaagtaaa ggaaatcttg agagagacaa ttagcaggat agttctacca tattccaagg gcacttga

720

780

840

900

948 <210> 1960 <211> 315 <212> PRT <213> Canis familiaris <400> 1960

Met Ala Met Arg Asn Gln Ser Thr Leu Thr Glu Phe Thr Leu Val Ser 1 5 10 15

Phe Pro Val Ile Gln Glu Leu Gln Ile Leu Leu Phe Val Ile Leu Leu 20 25 30

Met Val Tyr Ile Leu Thr Ile Thr Gly Asn Ile Val Ile Ile Ser Leu 35 40 45

Ile Trp Thr Asp Asn Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60

Asn Leu Ser Phe Leu Asp Ile Leu Phe Thr Thr Thr Ile Ala Pro Lys 65 70 75 80

Leu Leu Ala Cys Leu Leu Glu Lys Lys Lys Thr Ile Ser Phe Ala Gly 85 90 95

Cys Ile Thr Gln Ile Tyr Phe Tyr Phe Phe Leu Gly Thr Val Glu Phe 100 105 110

Ile Leu Leu Ala Val Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125

Pro Leu Arg Tyr Thr Ile Ile Met Asn Ser Arg Val Cys Leu Leu Leu 130 135 140

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Val Leu 145 Gly Cys Trp Val Gly Ala Phe Leu Ser Val Leu Cys Pro Thr 150 155 160 Ile Val Val Ser Arg Leu Pro Tyr Cys Thr Lys Glu Ile Ser His Phe 165 170 175 Phe Cys Asp Ile Ala Pro Leu Leu Gln Val Ala Cys Ile Asp Thr His 180 185 190 Phe Ile Glu Met Ile Asn Phe Leu Leu Ser Ser Phe Val Leu Leu Thr 195 200 205 Ser Leu Val Phe Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr Ile 210 215 220 Leu Arg Ile Pro Ser Ala Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ser His Ile Thr Val Val Ser Ile Ala Tyr Gly Ser Asn Ile Phe 245 250 255 Met Tyr Met Arg Pro Ser Gln Ser His Ser Leu Glu Phe Asp Lys Val 260 265 270 Thr Ala Val Leu Thr Thr Met Val Thr Pro Leu Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Glu Lys Val Lys Glu Ile Leu Arg Glu Thr Ile 290 295 300 Ser Arg Ile Val Leu Pro Tyr Ser Lys Gly Thr 305 310 315

<210> 1961 <211> 948 <212> DNA <213> Canis familiaris <400> 1961 atggatgtgc aaaatcagac cagagtgact gaatttacac tgactgcctt ccctgttatc

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cggaagcttc agatctccct ctttgtggtc ctcctgttta cttacatgct aactctaaca 120 ggaaatactg tcatcatttc cttaatatgg gctgataatc gcctccaaac cccaatgtac 180 ttctttctca gtaatttgtc atttttggac attctataca ctacctcagt taccccaaag 240 ctgttagctt gtctcctaga ggacaagaag accatatctt ttgctggctg catgacccaa 300 gtatacttct tttttttcct ggggacagtg gagtttatcc tcctggcagt gatgtccttt 360 gaccgctacg tggccatctg taaccctctg cgctacaccg ttatcatgaa cagcagggtc 420 tgtctcctgc tggttctggg ctgctggata ggggctttct tttctgtgct gtgcccaatt 480 atcgtggtct ccagactgcc ttactgttat agggaaattg gtcatttctt ctgtgacatt 540 gcccctttac tgcaggtagc ctgcatagac actcatttca ttgagatgat aaacttcctc 600 ttgtcctcct ttgtcctcct gacctcactg gtattcacca ttgtgtccta cacctacatc 660 atctctacca tcctgcgcat cccctcagcc caaggacgtc agaaggcctt ttccacctgt 720 gcttctcaca tcacggttgt gtccattgcc tatgggagca acatcttcat gtatgtgagg 780 cccagccaga gccattcact ggagtttgac aaagtgacag ctgtcatgac cataatggta 840 acccctcttc tgaatccctt catttatagt ctaaggaatg aaaaggtaaa ggaagttttg 900 agagaagcaa tcttcaaaat tatgtcctta tggcacaaga gaacttga 948

<210> 1962 <211> 315 <212> PRT <213> Canis familiaris

<400> 1962 Gln Thr Arg Val Thr Glu Phe Thr Leu Thr Ala Met 1 Asp Val Gln Asn 5 10 15 Phe Pro Val Ile Arg Lys Leu Gln Ile Ser Leu Phe Val Val Leu Leu 20 25 30 Phe Thr Tyr Met Leu Thr Leu Thr Gly Asn Thr Val Ile Ile Ser Leu 35 40 45 Ile Trp Ala Asp Asn Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60

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Asn 65 Leu Ser Phe Leu Asp Ile Leu Tyr Thr Thr Ser Val Thr Pro Lys 70 75 80 Leu Leu Ala Cys Leu Leu Glu Asp Lys Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Met Thr Gln Val Tyr Phe Phe Phe Phe Leu Gly Thr Val Glu Phe 100 105 110 Ile Leu Leu Ala Val Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Ser Arg Val Cys Leu Leu Leu 130 135 140 Val Leu Gly Cys Trp Ile Gly Ala Phe Phe Ser Val Leu Cys Pro Ile 145 150 155 160 Ile Val Val Ser Arg Leu Pro Tyr Cys Tyr Arg Glu Ile Gly His Phe 165 170 175 Phe Cys Asp Ile Ala Pro Leu Leu Gln Val Ala Cys Ile Asp Thr His 180 185 190 Phe Ile Glu Met Ile Asn Phe Leu Leu Ser Ser Phe Val Leu Leu Thr 195 200 205 Ser Leu Val Phe Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr Ile 210 215 220 Leu Arg Ile Pro Ser Ala Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ser His Ile Thr Val Val Ser Ile Ala Tyr Gly Ser Asn Ile Phe 245 250 255 Met Tyr Val Arg Pro Ser Gln Ser His Ser Leu Glu Phe Asp Lys Val 260 265 270

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Thr Ala Val Met Thr Ile Met Val Thr Pro Leu Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Glu Lys Val Lys Glu Val Leu Arg Glu Ala Ile 290 295 300 Phe Lys Ile Met Ser Leu Trp His Lys Arg Thr 305 310 315

<210> 1963 <211> 948 <212> DNA <213> Canis familiaris <400> 1963

atggatgtgc aaaatcagtc cagagtgact gaatttacgc tgactgcctt ccctgttatc 60 cggaagcttc agatctccct ctttgtggtc ctcctgttta cctacatgct aactctaaca 120 ggaaatactg tcatcatttc cttaatatgg gctgataatc gcctccaaac cccaatgtac 180 ttctttctca gtaatttgtc atttttggac attctataca ctacctcagt taccccaaag 240 ctgttagctt gtctcctaga ggacaagaaa accatatctt ttgctggctg catcacccaa 300 acatacttct tttttttcct ggggacagtg gagtttatcc tcctggcagt gatgtccttt 360 gaccgctacg tggccatctg taaccctctg cgctacaccg ttatcatgaa cagcagggtc 420 tgtctcctgc tggttctggg ctgctgggtg ggagccttcc tctcagtgct gtgcccaact 480 atcgtggtct ccagactgcc ttactgttat agggaaattg gtcatttctt ctgtgacatt 540 gcccctttac tgcaggtggc ctgcatagac actcatttca ttgagatgat aaacttcctc 600 ttgtcctcct ttgtcctcct gacctcactg gtattcacca tcgtgtccta cacctacatc 660 atctctacca tcctgcgcat cccctcagcc caaggacgtc agaaggcctt ttccacttgt 720 gcttctcaca tcacggttgt gtccattgcc tatgggagca acatcttcat gtatgtgagg 780 cccagccaga gccattcact ggagtttgac aaggtgacag ctgtcctcac gacaatggtg 840 acccctcttc tgaacccttt catttatagt ctaaggaata aaaaggtaaa ggaagttttg 900 agagaagcaa tccttaaaat tatgtcctta tggcacaaga gaacttga 948

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069269_0225_SL.TXT <210> 1964 <211> 315 <212> PRT <213> Canis familiaris

<400> 1964 Met 1 Asp Val Gln Asn Gln 5 Ser Arg Val Thr 10 Glu Phe Thr Leu Thr 15 Ala Phe Pro Val Ile Arg Lys Leu Gln Ile Ser Leu Phe Val Val Leu Leu 20 25 30 Phe Thr Tyr Met Leu Thr Leu Thr Gly Asn Thr Val Ile Ile Ser Leu 35 40 45 Ile Trp Ala Asp Asn Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Ile Leu Tyr Thr Thr Ser Val Thr Pro Lys 65 70 75 80 Leu Leu Ala Cys Leu Leu Glu Asp Lys Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Ile Thr Gln Thr Tyr Phe Phe Phe Phe Leu Gly Thr Val Glu Phe 100 105 110 Ile Leu Leu Ala Val Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Ser Arg Val Cys Leu Leu Leu 130 135 140 Val Leu Gly Cys Trp Val Gly Ala Phe Leu Ser Val Leu Cys Pro Thr 145 150 155 160 Ile Val Val Ser Arg Leu Pro Tyr Cys Tyr Arg Glu Ile Gly His Phe 165 170 175 Phe Cys Asp Ile Ala Pro Leu Leu Gln Val Ala Cys Ile Asp Thr His

Page 2205

180

069269_0225_SL.TXT 185 190

Phe Ile Glu Met Ile Asn Phe Leu Leu Ser Ser Phe Val Leu Leu Thr 195 200 205

Ser Leu Val Phe Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr Ile 210 215 220

Leu Arg Ile Pro Ser Ala Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240

Ala Ser His Ile Thr Val Val Ser Ile Ala Tyr Gly Ser Asn Ile Phe 245 250 255

Met Tyr Val Arg Pro Ser Gln Ser His Ser Leu Glu Phe Asp Lys Val 260 265 270

Thr Ala Val Leu Thr Thr Met Val Thr Pro Leu Leu Asn Pro Phe Ile 275 280 285

Tyr Ser Leu Arg Asn Lys Lys Val Lys Glu Val Leu Arg Glu Ala Ile 290 295 300

Leu Lys Ile Met Ser Leu Trp His Lys Arg Thr 305 310 315 <210> 1965 <211> 942 <212> DNA <213> Canis familiaris <400> 1965

atggggaatt ggagcatagt gaccgaattt accctaattg ccttccctgt tctcttagag 60 cttcgaatct tcctctttgt ggttcttttg ctgacttaca cactaacagc aacaggaaac 120 attatcatca tcttcctaat atggactgat aatcgcctgc aaactccaat gtacattttc 180 ctcagtaatt tgtcctgtct agatatttta tataccacgg tcattacccc aaagttgcta 240 gactgcctcc ttggagagaa gaaaaccata tcctttgctg gctgcatcac tcaaacgtat 300 ttctacttct ttctggggac agtggagttt atcctcttgg cggtgatgtc ctttgaccgc 360

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tacgtggcca tctgtaaccc cctgcgctac accaccatca tgaacagcag ggcctgccta 420 ctgctggttc tgggctgctg ggtgggagcc ttcctctccg tgttggtacc aaccattgta 480 gtgacaaggc tgccttattg taggaaagaa attaatcatt ttttctgtga cattgcccct 540 cttctgcaag tggcctgtgt agacacttac ctcattgagc agataaactt ccttctatct 600 gccctcgtca tcctgagctc cctagcattc acagctgggt cctacaccta catcatctct 660 accatcctgc gcattccctc agcccaaggc cgccagaaag ctttttctac ctgtgcttct 720 cacattacgg ttgtgtccat tgcttatggg agcaacatct ttgtgtatgt gagacccagt 780 cagaactatt ccctggattt tgacaaggta gctgctgtcc tcattacagt ggtgacccct 840 cttctgaacc cttttattta tagcttaaga aatgaaaagg tgaaagaagt gttgagagag 900 acaatgaaca gaatcatgtc cttgatacta aggaaaactt ga 942

<210> 1966 <211> 313 <212> PRT <213> Canis familiaris <400> 1966

Met Gly Asn Trp Ser Ile Val Thr Glu Phe Thr Leu Ile Ala Phe Pro 1 5 10 15 Val Leu Leu Glu Leu Arg Ile Phe Leu Phe Val Val Leu Leu Leu Thr 20 25 30 Tyr Thr Leu Thr Ala Thr Gly Asn Ile Ile Ile Ile Phe Leu Ile Trp 35 40 45 Thr Asp Asn Arg Leu Gln Thr Pro Met Tyr Ile Phe Leu Ser Asn Leu 50 55 60 Ser Cys Leu Asp Ile Leu Tyr Thr Thr Val Ile Thr Pro Lys Leu Leu 65 70 75 80 Asp Cys Leu Leu Gly Glu Lys Lys Thr Ile Ser Phe Ala Gly Cys Ile 85 90 95

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Thr Gln Thr Tyr 100 Phe Tyr Phe 069269_0225_SL.TXT Phe Leu Gly Thr Val Glu 105 Phe 110 Ile Leu Leu Ala Val Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Asn Ser Arg Ala Cys Leu Leu Leu Val Leu 130 135 140 Gly Cys Trp Val Gly Ala Phe Leu Ser Val Leu Val Pro Thr Ile Val 145 150 155 160 Val Thr Arg Leu Pro Tyr Cys Arg Lys Glu Ile Asn His Phe Phe Cys 165 170 175 Asp Ile Ala Pro Leu Leu Gln Val Ala Cys Val Asp Thr Tyr Leu Ile 180 185 190 Glu Gln Ile Asn Phe Leu Leu Ser Ala Leu Val Ile Leu Ser Ser Leu 195 200 205 Ala Phe Thr Ala Gly Ser Tyr Thr Tyr Ile Ile Ser Thr Ile Leu Arg 210 215 220 Ile Pro Ser Ala Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala Ser 225 230 235 240 His Ile Thr Val Val Ser Ile Ala Tyr Gly Ser Asn Ile Phe Val Tyr 245 250 255 Val Arg Pro Ser Gln Asn Tyr Ser Leu Asp Phe Asp Lys Val Ala Ala 260 265 270 Val Leu Ile Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr Ser 275 280 285 Leu Arg Asn Glu Lys Val Lys Glu Val Leu Arg Glu Thr Met Asn Arg 290 295 300

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069269_0225_SL.TXT Ile Met Ser Leu Ile Leu Arg Lys Thr 305 310 <210> 1967 <211> 939 <212> DNA <213> Canis familiaris <400> 1967 atgagaaatg gcacaacaat cacagagttc atcctggtag gctttcctga tatccaagga 60 ctacaaatcc ctctctttat agtgatcttt ttcatctaca tattaaccct tgtgggcaat 120 gggctcataa ttgtcattgt gtgggcagag cccaggctac aaataccaat gtacttcttc 180 ctttgcaact tgtccttcct agagacgtgg tacaccacca cagtcatccc caaactgttg 240 gagacttttg tggtggcaag agcaaccatt tccatcccct gctgtctact gcagtccttc 300 ttccactttt tcctgggtac cactgagttc tttatcctca ccatcatgtc ttttgaccgt 360 tacctggcca tctgcaagcc ccttcgctac cccaccatta tgaccagcaa cctctgcctg 420 caacttgcac tcagctcctg gatggtcggc tttaccattg tcttttgtca gatgcttctg 480 ctcatccagt tgccattctg tggcaacaat gtcatcaatc atttctactg tgatgttggt 540 cccattttga aagcagcctg cgtagacaca agcattctgg agctcctggg tcttttggcg 600 accatcctgg tgatcccagg gtcactcctc ttcacagtaa tttcttatat ctatatcctg 660 tccaccatcc tacagatccc ttcagccact ggcagacaaa agactttctc tacctgtgcc 720 tctcacctga cggtagtctc cctgctgtat ggtgctgtct tgttcatgta cctgagaccc 780 acaacacact cttcctttaa gattaataag gtggtgtcag tgctaaatac tatcctcaca 840 ccccttctga atcccttcat ttacacaatt agaaacaagg aggttaaagc agccctaagg 900 aagacaatga cttgtccaaa gactcatcat ccagagtaa 939 <210> 1968 <211> 312 <212> PRT <213> Canis familiaris <400> 1968

Met Arg Asn Gly Thr Thr Ile Thr Glu Phe Ile Leu Val Gly Phe Pro 1 5 10 15

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Asp Ile Gln Gly 20 Leu Gln Ile Pro Leu Phe Ile Val Ile Phe Phe Ile 25 30 Tyr Ile Leu Thr Leu Val Gly Asn Gly Leu Ile Ile Val Ile Val Trp 35 40 45 Ala Glu Pro Arg Leu Gln Ile Pro Met Tyr Phe Phe Leu Cys Asn Leu 50 55 60 Ser Phe Leu Glu Thr Trp Tyr Thr Thr Thr Val Ile Pro Lys Leu Leu 65 70 75 80 Glu Thr Phe Val Val Ala Arg Ala Thr Ile Ser Ile Pro Cys Cys Leu 85 90 95 Leu Gln Ser Phe Phe His Phe Phe Leu Gly Thr Thr Glu Phe Phe Ile 100 105 110 Leu Thr Ile Met Ser Phe Asp Arg Tyr Leu Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Pro Thr Ile Met Thr Ser Asn Leu Cys Leu Gln Leu Ala Leu 130 135 140 Ser Ser Trp Met Val Gly Phe Thr Ile Val Phe Cys Gln Met Leu Leu 145 150 155 160 Leu Ile Gln Leu Pro Phe Cys Gly Asn Asn Val Ile Asn His Phe Tyr 165 170 175 Cys Asp Val Gly Pro Ile Leu Lys Ala Ala Cys Val Asp Thr Ser Ile 180 185 190 Leu Glu Leu Leu Gly Leu Leu Ala Thr Ile Leu Val Ile Pro Gly Ser 195 200 205 Leu Leu Phe Thr Val Ile Ser Tyr Ile Tyr Ile Leu Ser Thr Ile Leu 210 215 220

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Gln Ile 225 Pro Ser Ala Thr Gly Arg Gln Lys Thr Phe Ser Thr Cys Ala 230 235 240 Ser His Leu Thr Val Val Ser Leu Leu Tyr Gly Ala Val Leu Phe Met 245 250 255 Tyr Leu Arg Pro Thr Thr His Ser Ser Phe Lys Ile Asn Lys Val Val 260 265 270 Ser Val Leu Asn Thr Ile Leu Thr Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Ile Arg Asn Lys Glu Val Lys Ala Ala Leu Arg Lys Thr Met Thr 290 295 300 Cys Pro Lys Thr His His Pro Glu

305 310 <210> 1969 <211> 948 <212> DNA <213> Canis familiaris <400> 1969

atgcctttag taagaatggc agctgagaat tcctctgtga cagagtttat cctctcaggc 60 ttaaccaacc agccaggact ccagattcct ctcttcttcc tgtttctagg tttctatgtg 120 gtcacggtgg tagggaacct gggcctgata accctgattg ggctgaattc tcacctgcac 180 acccccatgt actttttcct cttcaacttg tccttcatag atttctgcta ttccactgtt 240 atcactccca agatgctgat gaattttgtc ttgaggaaga acgtcatctc ctacgcaggg 300 tgtatgactc agctcttctt ctttctcttc tttgttgtat ctgagtcctt catcctgtca 360 gcaatggcat atgaccgcta tgccgccatc tgtaacccac tggtatacac tgccaccatg 420 tctcctcagg tctgcttcct ccttctgttg ggtgtctatg tgatggggtt tgctggagcc 480 atggcccaca cagtgtgcat ggtaagactg accttctgtg ccaacaatct ggttgaccac 540 tacatgtgcg acatccttcc ccttcttgag cgttcttgca ccagcaccta tgtcaatgag 600 ctggtagttt ttattgttgt gggcattgat attggtgtgc ccacagttac catcttcatt 660

Page 2211

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tcttatgccc tcatcctctc cagcattctc cgtattcatt ctaccaaggg caggtccaaa 720 gccttcagca cctgcagctc ccacataatt gctgtttccc tcttctttgg atcaggggca 780 tttatgtacc tcaaaccatc ctctctttta cctatgaatc aggggaaagt gtcctctttg 840 ttctacacca tcgttgtgcc catgctcaac ccactaatct acagcttgag gaataaggat 900 gtcaaaattg ctctgaagaa aacactgagc aagaaaccat tctcttga 948

<210> 1970 <211> 315 <212> PRT <213> Canis familiaris <400> 1970

Met Pro Leu 1 Val Arg Met Ala Ala 5 Glu Asn Ser Ser Val Thr Glu Phe 10 15 Ile Leu Ser Gly Leu Thr Asn Gln Pro Gly Leu Gln Ile Pro Leu Phe 20 25 30 Phe Leu Phe Leu Gly Phe Tyr Val Val Thr Val Val Gly Asn Leu Gly 35 40 45 Leu Ile Thr Leu Ile Gly Leu Asn Ser His Leu His Thr Pro Met Tyr 50 55 60 Phe Phe Leu Phe Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Thr Val 65 70 75 80 Ile Thr Pro Lys Met Leu Met Asn Phe Val Leu Arg Lys Asn Val Ile 85 90 95 Ser Tyr Ala Gly Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val 100 105 110 Val Ser Glu Ser Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Ala 115 120 125 Ala Ile Cys Asn Pro Leu Val Tyr Thr Ala Thr Met Ser Pro Gln Val 130 135 140

Page 2212

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Cys 145 Phe Leu Leu Leu Leu Gly Val Tyr Val Met Gly Phe Ala Gly Ala 150 155 160 Met Ala His Thr Val Cys Met Val Arg Leu Thr Phe Cys Ala Asn Asn 165 170 175 Leu Val Asp His Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Arg Ser 180 185 190 Cys Thr Ser Thr Tyr Val Asn Glu Leu Val Val Phe Ile Val Val Gly 195 200 205 Ile Asp Ile Gly Val Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu 210 215 220 Ile Leu Ser Ser Ile Leu Arg Ile His Ser Thr Lys Gly Arg Ser Lys 225 230 235 240 Ala Phe Ser Thr Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe 245 250 255 Gly Ser Gly Ala Phe Met Tyr Leu Lys Pro Ser Ser Leu Leu Pro Met 260 265 270 Asn Gln Gly Lys Val Ser Ser Leu Phe Tyr Thr Ile Val Val Pro Met 275 280 285 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ile Ala 290 295 300 Leu Lys Lys Thr Leu Ser Lys Lys Pro Phe Ser

305 310 315 <210> 1971 <211> 930 <212> DNA <213> Canis familiaris <400> 1971

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atgactctga gaaacagctc ctcagcaact gagtttatcc tagtgggatt atcagaacac 60 ccagagctcc agctacccct cttcctcttg ttcttaggga tatatgtgtt tactgtggtg 120 ggcaacatgg gcttgatcac cttaattggg ctgaattcta gccttcatac tccaatgtac 180 tttttcctct tcaacttgtc ttttatagat ctctgttatg ccagtgtgtt tacccctaaa 240 atgctgaatg gttttgtgtc agaaaatatc atctcttatg tgggatgcat gactcagcta 300 ttcttcttct gtttctttat caattctgaa tgctatgtgt tggtatcaat ggcctatgat 360 cgctatgtgg ctatctgcaa ccctctgctg tacacggtca acatgtcccc acaggtttgt 420 tctctgctga tgtttggttc atacgtgata gggtttgctg gagctatggc ccacactgga 480 agcatattga gactgacgtt ctgtaattcc aacatcatcc accattatct gtgtgaagtt 540 cttcctctct tgcagctctc ttgcaccagc acccatgtca atgagttggt gttttttatt 600 attgtgggag tggtcatcac aatatccagc atcagcatct tcatctctta tgcattgatt 660 ctctctaata tcctccgtat tccttctgct gagggcaggt ccaaagcctt tagcacatgt 720 ggctcccaca ttattgctgt tgctttgttt tttgggtcag gggcattcac ctatttaaca 780 acctcttttc ctggatctat ggaccagggt aaatttgcct cagtctttta taccaatgtg 840 gttcccatgc ttaacccttt tatctacagt ttgaggaata aggatgtgaa acttgccctg 900 ggtaaaaccc tgagaagagt gcttctctga 930

<210> 1972 <211> 309 <212> PRT <213> Canis familiaris

<400> 1972 Met 1 Thr Leu Arg Asn Ser Ser Ser Ala Thr Glu Phe Ile Leu Val Gly 5 10 15 Leu Ser Glu His Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 Gly Ile Tyr Val Phe Thr Val Val Gly Asn Met Gly Leu Ile Thr Leu 35 40 45 Ile Gly Leu Asn Ser Ser Leu His Thr Pro Met Tyr Phe Phe Leu Phe Page 2214

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50 55 60

Asn 65 Leu Ser Phe Ile Asp Leu Cys Tyr Ala Ser Val Phe Thr Pro Lys 70 75 80 Met Leu Asn Gly Phe Val Ser Glu Asn Ile Ile Ser Tyr Val Gly Cys 85 90 95 Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Ile Asn Ser Glu Cys Tyr 100 105 110 Val Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125 Leu Leu Tyr Thr Val Asn Met Ser Pro Gln Val Cys Ser Leu Leu Met 130 135 140 Phe Gly Ser Tyr Val Ile Gly Phe Ala Gly Ala Met Ala His Thr Gly 145 150 155 160 Ser Ile Leu Arg Leu Thr Phe Cys Asn Ser Asn Ile Ile His His Tyr 165 170 175 Leu Cys Glu Val Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr His 180 185 190 Val Asn Glu Leu Val Phe Phe Ile Ile Val Gly Val Val Ile Thr Ile 195 200 205 Ser Ser Ile Ser Ile Phe Ile Ser Tyr Ala Leu Ile Leu Ser Asn Ile 210 215 220 Leu Arg Ile Pro Ser Ala Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Ser His Ile Ile Ala Val Ala Leu Phe Phe Gly Ser Gly Ala Phe 245 250 255 Thr Tyr Leu Thr Thr Ser Phe Pro Gly Ser Met Asp Gln Gly Lys Phe

Page 2215

260

069269_0225_SL.TXT 265 270

Ala Ser Val Phe Tyr Thr Asn Val Val Pro Met Leu Asn Pro Phe Ile 275 280 285

Tyr Ser Leu Arg Asn Lys Asp Val Lys Leu Ala Leu Gly Lys Thr Leu 290 295 300

Arg Arg Val Leu Leu

305 <210> 1973 <211> 933 <212> DNA <213> Canis familiaris <400> 1973

atggctatgg aaaatgagtc ttcagtgact gaattcatcc tggtaggatt tacagatcaa 60 tctcagctcc agttacccct tttcttcctc tttttactga actatgtggt cactgtggta 120 ggaaatttga gcttcattaa tctaatttgc ctgaattctc acttgcacac tcccatatac 180 tttttcacct tcaacttatc cttcatagat ctctgccagt ctttggtcat tacacctaaa 240 atgctgatga actttgtgtc agagaagaat atcatctcct ttacagaatg catgactcag 300 ctggtttttt tctgtttctt tgcccattct gagtgctatg tgttgacagc catggcctat 360 gatcgctatg tggccatctg tcagctcctg gtgtacacgg tcaccatgtc ccctcaggtc 420 tgttctctgc tgatgtttgg ttcttatgtg atggggtttg ctggtgccat ggtccacaca 480 ggggacatgg tcagattgtc cttctgtgat tccaacatca tcaaccatta catgtgtgac 540 atcttccccc tctaccagct ctcctgcagc agcacctatg ccagtgagct ggtggattcc 600 attattgtga tcacagttgt cataatatcc agctccatta ttttcatttc ttatgttttg 660 atcctgtcca gtgtcctcca catctcatca gctctgggtt ggtccaaaac cttcagcacc 720 tgtggctccc acatagtaac tgttggtcta ttctatggat ctgggctgtt cacacatctc 780 aagacctctc cttctggttc tatgggccag gggaaattct tctcagtatt ttacacaaat 840 atagtaccca tgttgaaccc ttttatctat agtctaagga acaaggatgt caaatgtgct 900 ctgaaaaaaa ctctgaaaag aattgcaaat taa 933

Page 2216

069269_0225_SL.TXT <210> 1974 <211> 310 <212> PRT <213> Canis familiaris

<400> 1974 Met 1 Ala Met Glu Asn 5 Glu Ser Ser Val Thr 10 Glu Phe Ile Leu Val 15 Gly Phe Thr Asp Gln Ser Gln Leu Gln Leu Pro Leu Phe Phe Leu Phe Leu 20 25 30 Leu Asn Tyr Val Val Thr Val Val Gly Asn Leu Ser Phe Ile Asn Leu 35 40 45 Ile Cys Leu Asn Ser His Leu His Thr Pro Ile Tyr Phe Phe Thr Phe 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys Gln Ser Leu Val Ile Thr Pro Lys 65 70 75 80 Met Leu Met Asn Phe Val Ser Glu Lys Asn Ile Ile Ser Phe Thr Glu 85 90 95 Cys Met Thr Gln Leu Val Phe Phe Cys Phe Phe Ala His Ser Glu Cys 100 105 110 Tyr Val Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln 115 120 125 Leu Leu Val Tyr Thr Val Thr Met Ser Pro Gln Val Cys Ser Leu Leu 130 135 140 Met Phe Gly Ser Tyr Val Met Gly Phe Ala Gly Ala Met Val His Thr 145 150 155 160 Gly Asp Met Val Arg Leu Ser Phe Cys Asp Ser Asn Ile Ile Asn His 165 170 175

Page 2217

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Tyr Met Cys Asp Ile Phe Pro Leu Tyr Gln Leu Ser Cys Ser Ser Thr 180 185 190 Tyr Ala Ser Glu Leu Val Asp Ser Ile Ile Val Ile Thr Val Val Ile 195 200 205 Ile Ser Ser Ser Ile Ile Phe Ile Ser Tyr Val Leu Ile Leu Ser Ser 210 215 220 Val Leu His Ile Ser Ser Ala Leu Gly Trp Ser Lys Thr Phe Ser Thr 225 230 235 240 Cys Gly Ser His Ile Val Thr Val Gly Leu Phe Tyr Gly Ser Gly Leu 245 250 255 Phe Thr His Leu Lys Thr Ser Pro Ser Gly Ser Met Gly Gln Gly Lys 260 265 270 Phe Phe Ser Val Phe Tyr Thr Asn Ile Val Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Cys Ala Leu Lys Lys Thr 290 295 300 Leu Lys Arg Ile Ala Asn

305 310 <210> 1975 <211> 1026 <212> DNA <213> Canis familiaris <400> 1975 atgacagcgt gtaaggaggg agctgggttt tctattaatg ggattttctt ctgttctcac agatttccaa agaggagaat attggttaga aatgactcct tagtgactga attccttctt gctggattaa cagaccgccc tgagctccag caacctctct tcttcctgtt tctgatgatc tacatcgtca ccatggtggg caaccttggc ttgatcatcc tcatcggtct caattctcac ctccacaccc ccatgtacta tttcctcttc aatctatcct tcattgatct ctgttactct

120

180

240

300

Page 2218

069269_0225_SL.TXT

tctgttttta cccccaagat gctgatgaac tttgtatcaa aggacaatat catctcctat 360 gttgggtgca tgactcaact gttcttcttt ctcttttttg tcatctcaga atgctacatg 420 ttgacctcaa tggcctatga ccgctatgtg gccatctgta atccattgtt gtataaggtc 480 accatgtccc atcaggtctg ttccttgcta actgttgctg catatatgat gggatttgcc 540 agagcctctg cccacacggg gtgcatgctt agactaacgt tctgcaatgt caatatcatc 600 aaccattacc tgtgtgacat ccttcctctc ctccaactct cttgcaccag cacctatgtc 660 aatgaggtag tagttctgat agtcgtggga attaatatca cagtacccag ttttaccatc 720 ctgatttctt acgtcttcat cctcactagc attcttcata tcaaatctgc tcaaggaaga 780 tcaaaagcct tcagtacttg tagctctcac gtcattgctc tgtgtctttt ttttggatca 840 gcagcattca tgtatcttaa atattcttct cctggatcta tggagcaggg aaaaatttct 900 tcagtgttct atactaatgt gggacccatg ctcaatcccc tgatctacag tttgaggaat 960 aaggatgtca aaattgcact gcggaaagct ctgattagaa tatggaagag aaacattaga 1020

ttctag 1026 <210> 1976 <211> 341 <212> PRT <213> Canis familiaris <400> 1976

Met 1 Thr Ala Cys Lys Glu 5 Gly Ala Gly Phe Ser Ile Asn Gly Ile Phe 10 15 Phe Cys Ser His Arg Phe Pro Lys Arg Arg Ile Leu Val Arg Asn Asp 20 25 30 Ser Leu Val Thr Glu Phe Leu Leu Ala Gly Leu Thr Asp Arg Pro Glu 35 40 45 Leu Gln Gln Pro Leu Phe Phe Leu Phe Leu Met Ile Tyr Ile Val Thr 50 55 60 Met Val Gly Asn Leu Gly Leu Ile Ile Leu Ile Gly Leu Asn Ser His 65 70 75 80

Page 2219

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Leu His Thr Pro Met 85 Tyr Tyr Phe Leu Phe Asn Leu Ser Phe Ile Asp 90 95 Leu Cys Tyr Ser Ser Val Phe Thr Pro Lys Met Leu Met Asn Phe Val 100 105 110 Ser Lys Asp Asn Ile Ile Ser Tyr Val Gly Cys Met Thr Gln Leu Phe 115 120 125 Phe Phe Leu Phe Phe Val Ile Ser Glu Cys Tyr Met Leu Thr Ser Met 130 135 140 Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Leu Tyr Lys Val 145 150 155 160 Thr Met Ser His Gln Val Cys Ser Leu Leu Thr Val Ala Ala Tyr Met 165 170 175 Met Gly Phe Ala Arg Ala Ser Ala His Thr Gly Cys Met Leu Arg Leu 180 185 190 Thr Phe Cys Asn Val Asn Ile Ile Asn His Tyr Leu Cys Asp Ile Leu 195 200 205 Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr Tyr Val Asn Glu Val Val 210 215 220 Val Leu Ile Val Val Gly Ile Asn Ile Thr Val Pro Ser Phe Thr Ile 225 230 235 240 Leu Ile Ser Tyr Val Phe Ile Leu Thr Ser Ile Leu His Ile Lys Ser 245 250 255 Ala Gln Gly Arg Ser Lys Ala Phe Ser Thr Cys Ser Ser His Val Ile 260 265 270 Ala Leu Cys Leu Phe Phe Gly Ser Ala Ala Phe Met Tyr Leu Lys Tyr 275 280 285

Page 2220

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Ser Ser Pro Gly Ser Met Glu Gln 295 Gly Lys Ile Ser Ser Val Phe 300 Tyr 290 Thr Asn Val Gly Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn 305 310 315 320 Lys Asp Val Lys Ile Ala Leu Arg Lys Ala Leu Ile Arg Ile Trp Lys 325 330 335

Arg Asn Ile Arg Phe 340 <210> 1977 <211> 933 <212> DNA <213> Canis familiaris <400> 1977

atggccatag gaaatgactc ttcagtgacc gagtttatcc tgctgggttt aacacaacag 60 ccagaactcc agctgcctct cttcttcatt ttcttaggat tctatgtggt caccatggtg 120 gggaacatgg gcttgattct tctgattggg ctgaactctc acctgcacac tcccatgtac 180 tactttctct tcaacctttc attcattgat ttctgctact cgtctgtcat aatccctaga 240 atgctgatga gttttgtaaa acaaaacatt atctcttatc cagagtgcat gacacagctc 300 tgtttcttcg ctttctttgt tatcagtgag tgctgtattt tgacatcaat ggcctatgac 360 cggtatgtgg ccatctgtaa gcccctgctc tacaaagcca tcatgtccca tcaggtctgc 420 ctcatgttca tggcaggaac atatgggatg gggtttgtgg gtgcaatggc ccacaccgga 480 tgtatgctga gactcagctt ctgtgatggc aacatcatca atcattacat gtgtgacata 540 cctcctcttc tccagctctc ttgcacgagc acctacatca atgaggtggt ggttttcatt 600 gtggtgggca tcaatgtaat agtgcccagt ctcactatct ccatttctta caccttgatc 660 ctctccaaca tattccatat ccgttctaca gagggcaggt ccaaagcctt cagtacctgc 720 agctctcacg tagttactgt ttctctcttc tttggagcat cggcattcat gtaccttaag 780 ccctctcctg ctgggtccct ggatcgagat aaagtatcca cagtttttta taccatcgtg 840 gggccaatga tgaatccttt tatctacagt ttaaggaaca aagatgttaa aattgcactg 900

Page 2221

069269_0225_SL.TXT agtaagactt tgaagaaaag ggtgttctca taa

933 <210> 1978 <211> 310 <212> PRT <213> Canis familiaris <400> 1978

Met 1 Ala Ile Gly Asn 5 Asp Ser Ser Val Thr Glu Phe Ile Leu Leu Gly 10 15 Leu Thr Gln Gln Pro Glu Leu Gln Leu Pro Leu Phe Phe Ile Phe Leu 20 25 30 Gly Phe Tyr Val Val Thr Met Val Gly Asn Met Gly Leu Ile Leu Leu 35 40 45 Ile Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Ile Ile Pro Arg 65 70 75 80 Met Leu Met Ser Phe Val Lys Gln Asn Ile Ile Ser Tyr Pro Glu Cys 85 90 95 Met Thr Gln Leu Cys Phe Phe Ala Phe Phe Val Ile Ser Glu Cys Cys 100 105 110 Ile Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro 115 120 125 Leu Leu Tyr Lys Ala Ile Met Ser His Gln Val Cys Leu Met Phe Met 130 135 140 Ala Gly Thr Tyr Gly Met Gly Phe Val Gly Ala Met Ala His Thr Gly 145 150 155 160 Cys Met Leu Arg Leu Ser Phe Cys Asp Gly Asn Ile Ile Asn His Tyr 165 170 175

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Met Cys Asp Ile 180 Pro Pro Leu Leu Ile Asn Glu 195 Val Val Val Phe Ile 200 Pro Ser 210 Leu Thr Ile Ser Ile 215 Ser Phe 225 His Ile Arg Ser Thr 230 Glu Gly Ser Ser His Val Val 245 Thr Val Ser Met Tyr Leu Lys 260 Pro Ser Pro Ala Ser Thr Val 275 Phe Tyr Thr Ile Val 280 Tyr Ser 290 Leu Arg Asn Lys Asp 295 Val Lys 305 Lys Arg Val Phe Ser 310

Gln 185 Leu Ser Cys Thr Ser 190 Thr Tyr Val Val Gly Ile Asn 205 Val Ile Val Tyr Thr Leu Ile 220 Leu Ser Asn Ile Arg Ser Lys 235 Ala Phe Ser Thr Cys 240 Leu Phe 250 Phe Gly Ala Ser Ala 255 Phe Gly 265 Ser Leu Asp Arg Asp 270 Lys Val Gly Pro Met Met Asn 285 Pro Phe Ile Lys Ile Ala Leu 300 Ser Lys Thr Leu

<210> 1979 <211> 960 <212> DNA <213> Canis familiaris <400> 1979 atgtggcaga ggaatcagac ctttctggca tctctcatcc accttttcct tttctcctta ggcaacacgc tcactattct cctcatctgt ttcctgctca gtcagctctc cctcatggat gacttcatcc ttgaaggcct ctttgatgac accatattgg tcttccttat tgcagtgagt gctgatgccc agcttcacac acccatgtac ctaatgcatg tctccacaac catcccaaag

120

180

240

Page 2223

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atggctacca attatctatc tggcaagaag accatctcct ttgtgggctg cgctacccag 300 cacttcctct atttgtctct gggtggtggt gagtgtcttc tcttagttct catgtcctat 360 gaccgctatg ttgccatttg tcatccactt cgttatacca ttctcatgaa cagaaaggtg 420 ggattgatga tggctatcat gtcatggttg ggggcatcca taaactctct aattcacaca 480 gtgatcttga tgcatttccc tttctgtggg tctcggaaaa tccaccactt ctactgtgag 540 tttccagctg ttgtgaagtt ggtgtgtgga gacatcactg tttatgagac catagtgtat 600 atcagcagtg tcatacttct cctcttcccc attttcctag tttctacatc ttatggcttc 660 atcctccaca gtgtcattca gatgcattca gctgggagta agagaaatgc ctttgctact 720 tgtagctctc acctcattgt ggtttctttc tggtttgggg cctgcatctt ttcatatatg 780 aggcccaggt cccagcgtac tccattgcaa gacaaagttg gttctgtgtt ttatagcatc 840 attactccca ccctcaatcc tttgatttat actctccgga ataaggatat agctaaggct 900 atgagaagag tactagggag agatattctc actcagagac agcaattgcc attgccctga 960 <210> 1980 <211> 319 <212> PRT <213> Canis familiaris <400> 1980 Met Trp Gln Arg Asn Gln Thr Phe Leu Ala Asp Phe Ile Leu Glu Gly 1 5 10 15 Leu Phe Asp Asp Ser Leu Ile His Leu Phe Leu Phe Ser Leu Thr Ile 20 25 30 Leu Val Phe Leu Ile Ala Val Ser Gly Asn Thr Leu Thr Ile Leu Leu 35 40 45 Ile Cys Ala i Asp Ala Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Met Asp Leu Met His Val Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Ala Thr Asn Tyr Leu Ser Gly Lys Lys Thr Ile Ser Phe Val Gly

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85 90 95

Cys Ala Thr Gln His Phe Leu Tyr Leu Ser Leu Gly Gly Gly Glu Cys 100 105 110 Leu Leu Leu Val Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Ile Leu Met Asn Arg Lys Val Gly Leu Met Met 130 135 140 Ala Ile Met Ser Trp Leu Gly Ala Ser Ile Asn Ser Leu Ile His Thr 145 150 155 160 Val Ile Leu Met His Phe Pro Phe Cys Gly Ser Arg Lys Ile His His 165 170 175 Phe Tyr Cys Glu Phe Pro Ala Val Val Lys Leu Val Cys Gly Asp Ile 180 185 190 Thr Val Tyr Glu Thr Ile Val Tyr Ile Ser Ser Val Ile Leu Leu Leu 195 200 205 Phe Pro Ile Phe Leu Val Ser Thr Ser Tyr Gly Phe Ile Leu His Ser 210 215 220 Val Ile Gln Met His Ser Ala Gly Ser Lys Arg Asn Ala Phe Ala Thr 225 230 235 240 Cys Ser Ser His Leu Ile Val Val Ser Phe Trp Phe Gly Ala Cys Ile 245 250 255 Phe Ser Tyr Met Arg Pro Arg Ser Gln Arg Thr Pro Leu Gln Asp Lys 260 265 270 Val Gly Ser Val Phe Tyr Ser Ile Ile Thr Pro Thr Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Ile Ala Lys Ala Met Arg Arg Val

Page 2225

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290 295 300

Leu Gly Arg Asp Ile Leu Thr Gln Arg Gln Gln Leu Pro Leu Pro 305 310 315 <210> 1981 <211> 945 <212> DNA <213> Canis familiaris <400> 1981

atggagggag aaaaccacac gagtgtctct gagttcatcc tcctagggct ctccagccag 60 cctgaaaggc aagagttgat ctttgggctc ttccttgtca tgtacctggt tggggcagca 120 gggaacttgc tcatcatcct ggccattggc tctgactccc tcctccacac acctatgtac 180 ttcttcctca gcaacctttc cctggtggat ttctgcttca tctctgccac tgtccccaag 240 atgcttgtga atatccagat gcagacccag tccatttctt atggcggctg cttagcccag 300 atctacttct gcattttgct tgccaacatg gacaactttc tcctgacagc aatggcttat 360 gaccgctacg tggccatctg ccaccccctg cactactcca ctatgatgag tctgcaaatc 420 tgtgccctga tgctgggaag ctcctggctc attgccaatc tccactctct gctacacact 480 gccctcatgg ctcggctgga gttctgtgcc agcaacatca tcccttactt cttttgtgac 540 ctcattcccc tgctccagct ctcctgttct aacacccagc tcaaccagct catgattctg 600 ctggtggggg gcttgattgt cctcattcct tttctcagca ttcttgtgtc ctacatccgc 660 attgtgtctg ctgtgctcaa agtcccatct gcccagagca aacaaaaggc cttttccact 720 tgtggctctc atctcacggt agtcctcctc ttctatggga ccatcacagg ggtctacctg 780 aatccctcat cctcccactt agctgacaag gattcactgg cttcagtgat gtatatggtg 840 gtcacaccca tgctgaaccc cttcatctac tgcctgagga acaaggacat gaagggagct 900 ctaagaaaac tatttggagt gaagacttta tcctgtgggc tgtga 945

<210> 1982 <211> 314 <212> PRT <213> Canis familiaris <400> 1982

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Met 1 Glu Gly Glu Asn 5 His Thr Ser Val Ser Glu Phe Ile Leu Leu Gly 10 15 Leu Ser Ser Gln Pro Glu Arg Gln Glu Leu Ile Phe Gly Leu Phe Leu 20 25 30 Val Met Tyr Leu Val Gly Ala Ala Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Gly Ser Asp Ser Leu Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Leu Val Asp Phe Cys Phe Ile Ser Ala Thr Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Met Gln Thr Gln Ser Ile Ser Tyr Gly Gly 85 90 95 Cys Leu Ala Gln Ile Tyr Phe Cys Ile Leu Leu Ala Asn Met Asp Asn 100 105 110 Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Ser Thr Met Met Ser Leu Gln Ile Cys Ala Leu Met 130 135 140 Leu Gly Ser Ser Trp Leu Ile Ala Asn Leu His Ser Leu Leu His Thr 145 150 155 160 Ala Leu Met Ala Arg Leu Glu Phe Cys Ala Ser Asn Ile Ile Pro Tyr 165 170 175 Phe Phe Cys Asp Leu Ile Pro Leu Leu Gln Leu Ser Cys Ser Asn Thr 180 185 190 Gln Leu Asn Gln Leu Met Ile Leu Leu Val Gly Gly Leu Ile Val Leu 195 200 205

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Ile Pro Phe Leu Ser Ile Leu Val 215 Ser Tyr Ile Arg Ile Val Ser Ala 220 210 Val Leu Lys Val Pro Ser Ala Gln Ser Lys Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Leu Leu Phe Tyr Gly Thr Ile Thr 245 250 255 Gly Val Tyr Leu Asn Pro Ser Ser Ser His Leu Ala Asp Lys Asp Ser 260 265 270 Leu Ala Ser Val Met Tyr Met Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Cys Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300 Phe Gly Val Lys Thr Leu Ser Cys Gly Leu 305 310

<210> 1983 <211> 978 <212> DNA <213> Canis familiaris <400> 1983

atgagctcct ggcccgcgtc caactggacg gccccagccg agttcgtgat cctgggtttc 60 tccgggtggc cccaggggct gcggctgctg ctcttcgcct tcctgctgcc gctctacctg 120 gccacgctgg cgggaaacct gctcatcctg ggcctggctg tggcggagcc tgccctgcac 180 tgccccatgt acttcttcct gggagcgctg tccgccgtgg aggtggccta cacgctggcg 240 ctgactccgc gcatgctcgc cggcttcctg ctgccgcccg caggcctggc cgtggcccgc 300 tccacgtgcg ccgcgcagat gggcctcttt gtggcgctgg ggggcgccga gtgcctgctg 360 ctggccgcca tggccctgga ccgctacctg gccatctgcc gccccctcta ctacccccag 420 ctcatgagca cggcgctctg ctggggcctc ctggcctcct gctgtgccgg gggctcaatc 480 ctggccttgg ggctcaccac ggccattttc cagctgccct tctgccaggg gggcttagtg 540

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aaccacgtct tctgtgacct cccggcggtg ctgctgctgg cctgtgggga ccggcagctg 600 caggagcggg tgctgctggc agcttgcctg ctgctgctgg tgctgcctct ggccctgatc 660 ctgctttcct ataccagggt gctggtggtc atcctgggcg ttgggggatc tgcgggccgc 720 cgcaaggcgt tcaacacggt ggcgtcgcac ctcacggtgg ccgtgctgca ctacggctgc 780 gccacggcca tgtacgccag gcccctgagc agccgctccc tggaggagga caagctggtc 840 tcgctcatct acatcaacct cacaccactg ctctacccgg ccatctacac gctgcggaat 900 cgcgatgtgc agggtgccct gcagcgggtg ctcagcggca ggacgccagg gaccgtccac 960 caggctgagg gcaactaa 978

<210> 1984 <211> 325 <212> PRT <213> Canis familiaris

<400> 1984 Ala Ser Asn Trp Thr Ala Pro Ala Glu Phe Val Met Ser 1 Ser Trp Pro 5 10 15 Ile Leu Gly Phe Ser Gly Trp Pro Gln Gly Leu Arg Leu Leu Leu Phe 20 25 30 Ala Phe Leu Leu Pro Leu Tyr Leu Ala Thr Leu Ala Gly Asn Leu Leu 35 40 45 Ile Leu Gly Leu Ala Val Ala Glu Pro Ala Leu His Cys Pro Met Tyr 50 55 60 Phe Phe Leu Gly Ala Leu Ser Ala Val Glu Val Ala Tyr Thr Leu Ala 65 70 75 80 Leu Thr Pro Arg Met Leu Ala Gly Phe Leu Leu Pro Pro Ala Gly Leu 85 90 95 Ala Val Ala Arg Ser Thr Cys Ala Ala Gln Met Gly Leu Phe Val Ala 100 105 110

Leu Gly Gly Ala Glu Cys

Leu Leu Leu Ala Ala Met Ala Page 2229

Leu Asp Arg

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115 120 125 Tyr Leu Ala Ile Cys Arg Pro Leu Tyr Tyr Pro Gln Leu Met Ser Thr 130 135 140 Ala Leu Cys Trp Gly Leu Leu Ala Ser Cys Cys Ala Gly Gly Ser Ile 145 150 155 160 Leu Ala Leu Gly Leu Thr Thr Ala Ile Phe Gln Leu Pro Phe Cys Gln 165 170 175 Gly Gly Leu Val Asn His Val Phe Cys Asp Leu Pro Ala Val Leu Leu 180 185 190 Leu Ala Cys Gly Asp Arg Gln Leu Gln Glu Arg Val Leu Leu Ala Ala 195 200 205 Cys Leu Leu Leu Leu Val Leu Pro Leu Ala Leu Ile Leu Leu Ser Tyr 210 215 220 Thr Arg Val Leu Val Val Ile Leu Gly Val Gly Gly Ser Ala Gly Arg 225 230 235 240 Arg Lys Ala Phe Asn Thr Val Ala Ser His Leu Thr Val Ala Val Leu 245 250 255 His Tyr Gly Cys Ala Thr Ala Met Tyr Ala Arg Pro Leu Ser Ser Arg 260 265 270 Ser Leu Glu Glu Asp Lys Leu Val Ser Leu Ile Tyr Ile Asn Leu Thr 275 280 285 Pro Leu Leu Tyr Pro Ala Ile Tyr Thr Leu Arg Asn Arg Asp Val Gln 290 295 300 Gly Ala Leu Gln Arg Val Leu Ser Gly Arg Thr Pro Gly Thr Val His 305 310 315 320 Gln Ala Glu Gly Asn

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325 <210> 1985 <211> 939 <212> DNA <213> Canis familiaris <400> 1985

atgccagagg ccaacgacag cttcctggag ggcttcattc tgatgggtat atctgaccat 60 ccccagctgg agataatctt tttcatggtc attctcttct cttacttact gactctgctt 120 gggaactcaa ccattatcct gctttcctgg ctggatgccc ggctccatac tcccatgtac 180 ttcttcctca gcaacctctc caccctggac cttgctttta ctactagctc agtcccccaa 240 atgctgatca acttatgggg accagataag accataagct atggtggctg tgtgacccag 300 ctctatgttt tcctctggct aggggccact gagtgtatcc tgcttgtggt gatggcgttt 360 gaccgctatg tggcagtttg ccggcccctg cactacacca ccatcatgaa ccctcggctc 420 tgctggctgc tggctgccat tgcatggctg ggtggcttga gcaactctgt gatccagtca 480 accttcactc tgcagctccc cttatgtggg caccggaggg tggacaactt cctgtgtgag 540 gtacctgcca tgatcaaact ggcctgtgga gacacgagtc tcaatgaggt tgtgctcaat 600 ggtgtctgca ccttcttcac tgctgtccca ctaagtgtca tcctgatctc ctactgctac 660 atagctcagg cagtgctgaa gatccactca gtagagggac agagaaaggc ctttaatacg 720 tgcctctcac atctggtggt ggtgttgctc ttctatggct cagctatcta tgggtatctc 780 cttccagcta agaccagcaa ccaggaccag ggcaaattca tttccctctt ctactctgtg 840 gtcacaccaa cggtgaaccc tctcatctac actctgagaa atagggaagt aaagggagca 900 ctaaggaggc tgctaggaaa gggaagatca cttggctga 939

<210> 1986 <211> 312 <212> PRT <213> Canis familiaris <400> 1986

Met Pro Glu Ala Asn Asp Ser Phe Leu Glu Gly Phe Ile Leu Met Gly 1 5 10 15

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Ile Ser Asp His 20 Pro Gln Leu Glu Ile Ile Phe Phe Met Val Ile Leu 25 30 Phe Ser Tyr Leu Leu Thr Leu Leu Gly Asn Ser Thr Ile Ile Leu Leu 35 40 45 Ser Trp Leu Asp Ala Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Thr Leu Asp Leu Ala Phe Thr Thr Ser Ser Val Pro Gln 65 70 75 80 Met Leu Ile Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Gly Gly 85 90 95 Cys Val Thr Gln Leu Tyr Val Phe Leu Trp Leu Gly Ala Thr Glu Cys 100 105 110 Ile Leu Leu Val Val Met Ala Phe Asp Arg Tyr Val Ala Val Cys Arg 115 120 125 Pro Leu His Tyr Thr Thr Ile Met Asn Pro Arg Leu Cys Trp Leu Leu 130 135 140 Ala Ala Ile Ala Trp Leu Gly Gly Leu Ser Asn Ser Val Ile Gln Ser 145 150 155 160 Thr Phe Thr Leu Gln Leu Pro Leu Cys Gly His Arg Arg Val Asp Asn 165 170 175 Phe Leu Cys Glu Val Pro Ala Met Ile Lys Leu Ala Cys Gly Asp Thr 180 185 190 Ser Leu Asn Glu Val Val Leu Asn Gly Val Cys Thr Phe Phe Thr Ala 195 200 205 Val Pro Leu Ser Val Ile Leu Ile Ser Tyr Cys Tyr Ile Ala Gln Ala 210 215 220

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Val 225 Leu Lys Ile His Ser Val 230 Glu Gly Gln Arg Lys Ala Phe Asn Thr 235 240 Cys Leu Ser His Leu Val Val Val Leu Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Tyr Gly Tyr Leu Leu Pro Ala Lys Thr Ser Asn Gln Asp Gln Gly Lys 260 265 270 Phe Ile Ser Leu Phe Tyr Ser Val Val Thr Pro Thr Val Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Arg Glu Val Lys Gly Ala Leu Arg Arg Leu 290 295 300 Leu Gly Lys Gly Arg Ser Leu Gly 305 310

<210> 1987 <211> 930 <212> DNA <213> Canis familiaris <400> 1987

atgagagggg caaaccagtc aagtgtctcc aagttcctcc tcctcgggct ctccaggcag 60 ccccagcagc agcagcttct ctttgtcctc ttcctgagca tgtacctggc caccatcctg 120 ggaaacctgc tcatcctcct ggccatcagc gtggactcct gcctgcacat ccccatgtac 180 ttcttcctca gcaacctgtc ctttgtggac atctgcttct cctccaccac tgtccccaag 240 atgctgacca accacttact tggcactcag accatctcct tctctggctg cctcacacag 300 atgtacatgt ttgtggacat ggacaatttc ctcctcgctg tgatggccta tgactgcttt 360 gtagccatat gccacccctt acactactca acaaagatga cccaccagct ctgtgccctg 420 ctggttgctg ggtcgtgggt cattgccaac ctggatgtcc tactgcatac cctggtgatg 480 gctcaactct cattctgtag agacaatgcc atcccccact tcttctgtga tgcaaagccc 540 ctcctgaaac tctcctgctg acacacacct cctgctgagg tgatgattct ttttgaagca 600 gggttgatca tgatcactcc ctttatttgc atcctggctt catatatccg caatacctgt 660

Page 2233

069269_0225_SL.TXT gctatcctga gagtcccatt cacaaaggga agatggaaag ccttctccac ctgtgaatcc cacctggctg tggtttctct cttctatggc accatcatta ctgtgtattt caatccttta tcctcctact tagctgagac agatatagca gccactgtaa tgttcagtgt ggtgactccc atgctgaacc ccttcatcta cagcctgaga aacaaggaca taaaaggggc tcttggaaaa gtgcttgcta tgaatttttt tctacttggt

720

780

840

900

930 <210> 1988 <211> 186 <212> PRT <213> Canis familiaris <400> 1988

Met Arg Gly 1 Ala Asn Gln Ser Ser 5 Val Ser Lys Phe Leu Leu Leu Gly 10 15 Leu Ser Arg Gln Pro Gln Gln Gln Gln Leu Leu Phe Val Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ala Thr Ile Leu Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 Ile Ser Val Asp Ser Cys Leu His Ile Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Ser Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Thr Asn His Leu Leu Gly Thr Gln Thr Ile Ser Phe Ser Gly 85 90 95 Cys Leu Thr Gln Met Tyr Met Phe Val Asp Met Asp Asn Phe Leu Leu 100 105 110 Ala Val Met Ala Tyr Asp Cys Phe Val Ala Ile Cys His Pro Leu His 115 120 125 Tyr Ser Thr Lys Met Thr His Gln Leu Cys Ala Leu Leu Val Ala Gly 130 135 140

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Ser 145 Trp Val Ile Ala Asn Leu Asp Val Leu Leu His Thr Leu Val Met 150 155 160 Ala Gln Leu Ser Phe Cys Arg Asp Asn Ala Ile Pro His Phe Phe Cys 165 170 175 Asp Ala Lys Pro Leu Leu Lys Leu Ser Cys 180 185

<210> 1989 <211> 924 <212> DNA <213> Canis familiaris <400> 1989

ttaatgatgg gaaaccagat atcagtgata gaattcattc ttcttggact gacgaatgac 60 actgagcttc aagctgtgct tttccttttt ctgctgctaa cttatgtctt aagcatcctg 120 ggaaacttga ccatcatcat tctgaccctt ttggattatc gccttcagac tccgatgtat 180 ttctttctcc ggaatttttc tgttttggaa atatctttta cttctgtctt tgttcccaaa 240 atgctagtca atattgcaac tggagacaag actatctcct tcgctggttg tttcactcag 300 tatttttttg ccatccttct gggggcaact gaattttatc ttttagctgc catgtcctat 360 gattgctatg ctgccatttg taaacccctg cattatacaa ctgtaatgag caggaaactg 420 tgcattcagc ttgttctgtg ttcctggttc tctggttttt tggttgtcat tgtgccacat 480 acaatgactc tccaactgcc tttctgtgcc tccaatgtca tcaatcattg ttgctgtgac 540 tataccatac tgctgcatct gtcctgttaa gacacacagt tcatagaagt gatggagttt 600 atctttgcag cagttaccct catcttcacc ttggtgctag tgattctttc ctacacgtac 660 ataatcagga caattctgag aatcccttct gttcaacaaa gaaaaaaagc cttttctaca 720 tgctcctgtc acatgattgt ggtctcactt tcttatggaa gttgtatctt tatgtacata 780 aatccttctg ttaaggatgc agaaactttt aataagagag tggctgtttt aaatacctca 840 gttgcccctc tgttgaaccc tttcatctat atcctaagga aaaagcaagt gaaaatagcc 900 ttcaaagaca tggtcagcaa gata 924

Page 2235

069269_0225_SL.TXT <210> 1990 <211> 189 <212> PRT <213> Canis familiaris

<400> 1990 Phe Ile Leu Leu 15 Gly Leu 1 Met Met Gly Asn Gln 5 Ile Ser Val Ile 10 Glu Leu Thr Asn Asp Thr Glu Leu Gln Ala Val Leu Phe Leu Phe Leu Leu 20 25 30 Leu Thr Tyr Val Leu Ser Ile Leu Gly Asn Leu Thr Ile Ile Ile Leu 35 40 45 Thr Leu Leu Asp Tyr Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Phe Ser Val Leu Glu Ile Ser Phe Thr Ser Val Phe Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Ala Thr Gly Asp Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Phe Thr Gln Tyr Phe Phe Ala Ile Leu Leu Gly Ala Thr Glu Phe 100 105 110 Tyr Leu Leu Ala Ala Met Ser Tyr Asp Cys Tyr Ala Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Thr Thr Val Met Ser Arg Lys Leu Cys Ile Gln Leu 130 135 140 Val Leu Cys Ser Trp Phe Ser Gly Phe Leu Val Val Ile Val Pro His 145 150 155 160 Thr Met Thr Leu Gln Leu Pro Phe Cys Ala Ser Asn Val Ile Asn His 165 170 175 Cys Cys Cys Asp Tyr Thr Ile Leu Leu His Leu Ser Cys

180 185

Page 2236

069269_0225_SL.TXT <210> 1991 <211> 843 <212> DNA <213> Canis familiaris <400> 1991

atggaaaacc atacaactgt gacagtattg acggaggacc caaaactgaa gattgtgcta 60 tttgtcttcc tgctcctcac ctacttgcta agcatctcag gcaacttagt tattattacc 120 ctcactttgc tggactcaca tctcaagacc cctatgtatt tctttcttcg aaatgtttct 180 ttcttagaaa tttcttatac gacagtctgc atccccaaat tgcttgtaag catggcaact 240 ggtgacaaaa ccatttccta taactgttgt gcaactcagt tgtttgcctt ccttcttgga 300 gcatctgaat gttacctcct ggctgtcatg tcctacaatc attatgtcgc catctgcaag 360 cccctgcatt acacaaccat tatgagcagc aaaatctgta tccagctagt ccttagctct 420 tggatcactg gtttcctcac catctttcca ggactcattt taggcttaag cctggacttc 480 tgtgattcca atgtcattga tcatttctac tgtgacactg ttcccctcct gcagatctcc 540 tgcacagaca gacacatgtt ggaaatgatg agtttcatct tagctttggt gactctgctg 600 gtcactttgg cattagtaat tttaaaaaat tccttctgcc aaccacagaa aaaagctttc 660 tccacctgtt cttctcacat gattgtcatc tccctctcat atggcagctg catctatgta 720 ccttaaaccc tcaaacagag gatatccttg atgaagggag tggcagttct caatacttct 780 gttgctccac ttttgaatcc ctttatttat actctaagga aacaacaggt gaagcaagca 840

ttt 843 <210> 1992 <211> 241 <212> PRT <213> Canis familiaris <400> 1992

Met Glu Asn His Thr Thr Val Thr Val Leu Thr Glu Asp Pro Lys Leu 1 5 10 15

Lys Ile Val Leu Phe Val Phe Leu Leu Leu Thr Tyr Leu Leu Ser Ile 20 25 30

Page 2237

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Ser Gly Asn 35 Leu Val Ile Ile Thr Leu Thr Leu Leu Asp Ser His Leu 40 45 Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Val Ser Phe Leu Glu Ile 50 55 60 Ser Tyr Thr Thr Val Cys Ile Pro Lys Leu Leu Val Ser Met Ala Thr 65 70 75 80 Gly Asp Lys Thr Ile Ser Tyr Asn Cys Cys Ala Thr Gln Leu Phe Ala 85 90 95 Phe Leu Leu Gly Ala Ser Glu Cys Tyr Leu Leu Ala Val Met Ser Tyr 100 105 110 Asn His Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Thr Thr Ile Met 115 120 125 Ser Ser Lys Ile Cys Ile Gln Leu Val Leu Ser Ser Trp Ile Thr Gly 130 135 140 Phe Leu Thr Ile Phe Pro Gly Leu Ile Leu Gly Leu Ser Leu Asp Phe 145 150 155 160 Cys Asp Ser Asn Val Ile Asp His Phe Tyr Cys Asp Thr Val Pro Leu 165 170 175 Leu Gln Ile Ser Cys Thr Asp Arg His Met Leu Glu Met Met Ser Phe 180 185 190 Ile Leu Ala Leu Val Thr Leu Leu Val Thr Leu Ala Leu Val Ile Leu 195 200 205 Lys Asn Ser Phe Cys Gln Pro Gln Lys Lys Ala Phe Ser Thr Cys Ser 210 215 220 Ser His Met Ile Val Ile Ser Leu Ser Tyr Gly Ser Cys Ile Tyr Val 225 230 235 240

Page 2238

069269_0225_SL.TXT <210> 1993 <211> 642 <212> DNA <213> Canis familiaris <400> 1993

Pro

caattgtttt ttaccttcct tcttggtgca tctgaatttt gcttgctggc agctatgtcc 60 tatgaccgct atgttgccat ttgtaagccc ctgcattaca caaccatcat gagcaataag 120 atctgcatgc aacttgtctt ctgttgttgg tttgctgggt cttttgtcat ctttccacct 180 ctcctcttag gcttaaatga cttctatgcc ttcaacattg ttgatcattt ctactgtgct 240 acaacccccc tgctgcagat ctcctgctca gacacacagc tcttagagac aatgggatac 300 atctctgctt tggtgacact catagtcaca ttggtaatgg tgataatatc atatacctac 360 attgtattaa gaattctaaa aatcctttca gtcaatcaga ggaaaaaggc tttttcaaca 420 tgttcttctc acatgattgt gatatccctt tcttatggca gctgcatctt catgtatgtt 480 aagccatcag tcaaacaaag aacatcttat tccaagggaa ttgcagtgct caacacctct 540 gttgctctac ttttgaatcc tttcatctac actttgtgga acaagcaagt aaaaacagcc 600 ttcatgaaca tggtacacaa aattgtttct ttctcaaaca aa 642

<210> 1994 <211> 214 <212> PRT <213> Canis familiaris <400> 1994

Gln 1 Leu Phe Phe Thr 5 Phe Leu Leu Gly Ala Ser 10 Glu Phe Cys Leu 15 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His 20 25 30 Tyr Thr Thr Ile Met Ser Asn Lys Ile Cys Met Gln Leu Val Phe Cys 35 40 45

Page 2239

Cys Trp 50 Phe Ala Gly Ser Phe 55 069269_0225_SL.TXT Val Ile Phe Pro Pro Leu 60 Leu Leu Gly Leu Asn Asp Phe Tyr Ala Phe Asn Ile Val Asp His Phe Tyr Cys Ala 65 70 75 80 Thr Thr Pro Leu Leu Gln Ile Ser Cys Ser Asp Thr Gln Leu Leu Glu 85 90 95 Thr Met Gly Tyr Ile Ser Ala Leu Val Thr Leu Ile Val Thr Leu Val 100 105 110 Met Val Ile Ile Ser Tyr Thr Tyr Ile Val Leu Arg Ile Leu Lys Ile 115 120 125 Leu Ser Val Asn Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser His 130 135 140 Met Ile Val Ile Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met Tyr Val 145 150 155 160 Lys Pro Ser Val Lys Gln Arg Thr Ser Tyr Ser Lys Gly Ile Ala Val 165 170 175 Leu Asn Thr Ser Val Ala Leu Leu Leu Asn Pro Phe Ile Tyr Thr Leu 180 185 190 Trp Asn Lys Gln Val Lys Thr Ala Phe Met Asn Met Val His Lys Ile 195 200 205 Val Ser Phe Ser Asn Lys

210 <210> 1995 <211> 909 <212> DNA <213> Canis familiaris <400> 1995 atgaaaaacc attcaacgga aatagagttt attctcataa gactgacgga tgacccacaa

Page 2240

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ttgcaagttg tgatttttgt gtttttattt cttaattaca cattgagcct gatggggaac 120 ttaaccatta tcctcctcac tctgctggat cctcacctca agatgccaat gtatttcttt 180 ctccgtaatt tctcattttt agaaatcata ttcacaacgg tatgtattcc cagatacttg 240 aaaaccatag tgactaaaga aaaatttttt attattttac tgggagttgc agagttttac 300 cttctggctg ctatgtccta tgaccactat gttgccatct ctaaaccctt gcattactca 360 atcattatga acagcagagt gtgctattgg cttgtacttt cttcctggct gactggattc 420 ctaatcatct ttcccctatt gctcatggga ctcaagctgg atttctgtgc ttccaaaacg 480 attgatcact ttatgtgtga aacttccccc atcctgcaga tatcctgcac agacacacat 540 gtcctagaat tgatgtcttt catattcgct gtggtgacac ttgtggtcac attggtgtta 600 gtggttctct cctacacttt catcatgaag accattatga aattcccttc tgcacagcaa 660 aggaccaaag ctttttccac ctgtacttcc catatgattg ttgtctccat gacatatggg 720 agctgcatct ttatgtatat taagccatct gccaaagaaa gggtgactgt atccaaagat 780 gtagctttgc tgtatacctc aattgcccct ttactaaatc ccttcattta taccctaagg 840 aaccagcagg tgaaagaaat attttgggat atgttacaaa aaaggttgtg tctttcaaaa 900

aaacaattg 909 <210> 1996 <211> 303 <212> PRT <213> Canis familiaris <400> 1996

Met 1 Lys Asn His Ser Thr 5 Glu Ile Glu Phe Ile Leu Ile Arg Leu Thr 10 15 Asp Asp Pro Gln Leu Gln Val Val Ile Phe Val Phe Leu Phe Leu Asn 20 25 30 Tyr Thr Leu Ser Leu Met Gly Asn Leu Thr Ile Ile Leu Leu Thr Leu 35 40 45 Leu Asp Pro His Leu Lys Met Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60

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Ser 65 Phe Leu Glu Ile Ile Phe Thr Thr Val Cys Ile Pro Arg Tyr Leu 70 75 80 Lys Thr Ile Val Thr Lys Glu Lys Phe Phe Ile Ile Leu Leu Gly Val 85 90 95 Ala Glu Phe Tyr Leu Leu Ala Ala Met Ser Tyr Asp His Tyr Val Ala 100 105 110 Ile Ser Lys Pro Leu His Tyr Ser Ile Ile Met Asn Ser Arg Val Cys 115 120 125 Tyr Trp Leu Val Leu Ser Ser Trp Leu Thr Gly Phe Leu Ile Ile Phe 130 135 140 Pro Leu Leu Leu Met Gly Leu Lys Leu Asp Phe Cys Ala Ser Lys Thr 145 150 155 160 Ile Asp His Phe Met Cys Glu Thr Ser Pro Ile Leu Gln Ile Ser Cys 165 170 175 Thr Asp Thr His Val Leu Glu Leu Met Ser Phe Ile Phe Ala Val Val 180 185 190 Thr Leu Val Val Thr Leu Val Leu Val Val Leu Ser Tyr Thr Phe Ile 195 200 205 Met Lys Thr Ile Met Lys Phe Pro Ser Ala Gln Gln Arg Thr Lys Ala 210 215 220 Phe Ser Thr Cys Thr Ser His Met Ile Val Val Ser Met Thr Tyr Gly 225 230 235 240 Ser Cys Ile Phe Met Tyr Ile Lys Pro Ser Ala Lys Glu Arg Val Thr 245 250 255 Val Ser Lys Asp Val Ala Leu Leu Tyr Thr Ser Ile Ala Pro Leu Leu 260 265 270

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Asn Pro Phe Ile Tyr Thr Leu Arg Asn Gln Gln Val Lys Glu Ile Phe 275 280 285

Trp Asp Met Leu Gln Lys Arg Leu Cys Leu Ser Lys Lys Gln Leu 290 295 300

<210> 1997 <211> 954 <212> DNA <213> Canis familiaris <400> 1997

atggtgatcc tgccctggga aaaccaaaca accatagtgg aatttatgct tcaaggattc 60 tcctctatcc gacagctaaa tatctttctc tttataatgt ttttagtttt ctatgtctta 120 gtcatttctg gcaacatcct cattgttctg ctagttttgt tcatccatca cctccacacc 180 cccatgtact tcttcctggt gaacttgtcc tttctagaga tctgctatac ctccaatatt 240 gtccccaaga tgttactgat caccatagct gaacagagga ctatctctgt tgctgggtgc 300 atggcacagt tctacttctt tggatctctg gctgcaacag agtgtcttct gctggctgtg 360 atgtcctatg accgatacct ggccatctgc caacctctcc actatcccat cctcatgact 420 ggcccccttt gcattaggct agctgccagc tcttggctct gctgcttcct tcttacagca 480 atcactatgg tcttactatc tagattgacc ttctgtggac ctaatgaaat tgatcacttc 540 ttctgtgact tcacccctct cgtccacctc tcctgcacag acacctcact gacggagacc 600 atcgcctttg ccacctcttc ggcagtaact ctggttccgt ttctcctcat cgcagcctcc 660 tactcctgca ttcttattgc tatcctaaga attccacctg gcacaggtcg gagaaaggcc 720 ttctccacct gctcctccca cctcaccgtg gtcacagtgt tttatgggac actgattgcc 780 acgtatcttg tgccttcagc caattcttca caactcttgc gcaaaggatt ctctcttctc 840 tataccatcc tgacacccat gttcaacccc atcatctaca gcctaagaaa cagagacatc 900 catgaagccc tgaagatgtg cttgagtaag aagccaggat tcctccttag atga 954

<210> 1998 <211> 317 <212> PRT <213> Canis familiaris

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<400> 1998 Pro Trp Glu Asn Gln Thr Thr Ile Val Glu Phe 15 Met Met 1 Val Ile Leu 5 10 Leu Gln Gly Phe Ser Ser Ile Arg Gln Leu Asn Ile Phe Leu Phe Ile 20 25 30 Met Phe Leu Val Phe Tyr Val Leu Val Ile Ser Gly Asn Ile Leu Ile 35 40 45 Val Leu Leu Val Leu Phe Ile His His Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Val Asn Leu Ser Phe Leu Glu Ile Cys Tyr Thr Ser Asn Ile 65 70 75 80 Val Pro Lys Met Leu Leu Ile Thr Ile Ala Glu Gln Arg Thr Ile Ser 85 90 95 Val Ala Gly Cys Met Ala Gln Phe Tyr Phe Phe Gly Ser Leu Ala Ala 100 105 110 Thr Glu Cys Leu Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Leu Ala 115 120 125 Ile Cys Gln Pro Leu His Tyr Pro Ile Leu Met Thr Gly Pro Leu Cys 130 135 140 Ile Arg Leu Ala Ala Ser Ser Trp Leu Cys Cys Phe Leu Leu Thr Ala 145 150 155 160 Ile Thr Met Val Leu Leu Ser Arg Leu Thr Phe Cys Gly Pro Asn Glu 165 170 175 Ile Asp His Phe Phe Cys Asp Phe Thr Pro Leu Val His Leu Ser Cys 180 185 190 Thr Asp Thr Ser Leu Thr Glu Thr Ile Ala Phe Ala Thr Ser Ser Ala 195 200 205

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Val Thr Leu Val Pro Phe Leu Leu Ile Ala Ala Ser Tyr Ser Cys Ile 210 215 220 Leu Ile Ala Ile Leu Arg Ile Pro Pro Gly Thr Gly Arg Arg Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Thr Val Phe Tyr Gly 245 250 255 Thr Leu Ile Ala Thr Tyr Leu Val Pro Ser Ala Asn Ser Ser Gln Leu 260 265 270 Leu Arg Lys Gly Phe Ser Leu Leu Tyr Thr Ile Leu Thr Pro Met Phe 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Arg Asp Ile His Glu Ala Leu 290 295 300 Lys Met Cys Leu Ser Lys Lys Pro Gly Phe Leu Leu Arg

305 310 315 <210> 1999 <211> 960 <212> DNA <213> Canis familiaris <400> 1999

atggatataa caaaccaaac aagagtgaca gagttcattt ttcttgggtt tcctggtgtt 60 ctacatctgc ggatcacctt gtttgtgata tttcttattg tatatctgct ctccctcatg 120 ggaaataccc tcattatttt cattgttctc atggatatca cactccaaac acctatgtac 180 attttcttag gaaatttgtc attcctggag atctggtaca ccacagccac ggtacctaaa 240 ttgctggaca tctgcctctc acaggttgtt accatctctg tttctggttg tatcacccag 300 tactacttct ttttctctat gggagctaca gagtgcatac tgctggcagt gatggcctat 360 gatcggtacc tggccatctg cagtcctctc cattattcac tcctcatgag tattcgtatg 420 tgcctgcggt tttcagctgg atcttggatt gggggcttca ttgcccctct cccacctacc 480

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atactcattt ctcatctaaa tttctgtggc cctcagaaga ttaaccattt cttttgtgac 540 tcagacccca ttttcaaact ctcttgctca gatacacttt tggtggagac tttgggttac 600 acatgtacct ctgtcgtgat tctaagttct ttccttctca ctatgtcctc ttatggctac 660 atagtggtca caataatcaa gctgtcttcc caaaaggcac aaaaaaaaac tttctccacc 720 tgtgcctccc atctcactgt ggtctctatc tattatggca ccattatctt tgcctatgtt 780 caccctccag cgaagcacaa cttcaccatt ggtaaagtga tctcagtgtt ttactgtgtg 840 gttacccctt tggtaaaccc tctcatatat acactgagaa acaaagatgt gaagacagct 900 ttcagaaaag ttctagcaag aaagatattg cttttgacca caaacatgca aaggatttga 960

<210> 2000 <211> 319 <212> PRT <213> Canis familiaris

<400> 2000 Gln Thr Arg Val Thr Glu Phe Ile Phe Leu Gly Met Asp 1 Ile Thr Asn 5 10 15 Phe Pro Gly Val Leu His Leu Arg Ile Thr Leu Phe Val Ile Phe Leu 20 25 30 Ile Val Tyr Leu Leu Ser Leu Met Gly Asn Thr Leu Ile Ile Phe Ile 35 40 45 Val Leu Met Asp Ile Thr Leu Gln Thr Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Val Pro Lys 65 70 75 80 Leu Leu Asp Ile Cys Leu Ser Gln Val Val Thr Ile Ser Val Ser Gly 85 90 95 Cys Ile Thr Gln Tyr Tyr Phe Phe Phe Ser Met Gly Ala Thr Glu Cys 100 105 110

Ile Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Ser Page 2246

115 069269_0225_SL.TXT 120 125 Pro Leu His Tyr Ser Leu Leu Met Ser Ile Arg Met Cys Leu Arg Phe 130 135 140 Ser Ala Gly Ser Trp Ile Gly Gly Phe Ile Ala Pro Leu Pro Pro Thr 145 150 155 160 Ile Leu Ile Ser His Leu Asn Phe Cys Gly Pro Gln Lys Ile Asn His 165 170 175 Phe Phe Cys Asp Ser Asp Pro Ile Phe Lys Leu Ser Cys Ser Asp Thr 180 185 190 Leu Leu Val Glu Thr Leu Gly Tyr Thr Cys Thr Ser Val Val Ile Leu 195 200 205 Ser Ser Phe Leu Leu Thr Met Ser Ser Tyr Gly Tyr Ile Val Val Thr 210 215 220 Ile Ile Lys Leu Ser Ser Gln Lys Ala Gln Lys Lys Thr Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ser Ile Tyr Tyr Gly Thr Ile Ile 245 250 255 Phe Ala Tyr Val His Pro Pro Ala Lys His Asn Phe Thr Ile Gly Lys 260 265 270 Val Ile Ser Val Phe Tyr Cys Val Val Thr Pro Leu Val Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Thr Ala Phe Arg Lys Val 290 295 300 Leu Ala Arg Lys Ile Leu Leu Leu Thr Thr Asn Met Gln Arg Ile 305 310 315

<210> 2001

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069269_0225_SL.TXT <211> 927 <212> DNA <213> Canis familiaris <400> 2001

atgaaaaaca ggacgtttac tgagtttatt ctgttgggct tcacaaatca acctgatatc 60 caggttgtca tattcatctt tcttttcatc acctacatac taagtgtcct aggaaatttg 120 actatcatca ttctcactct agtagatcct cacctccaga cccccatgta tttcttcctc 180 cggaatttct ccttcttaga agtttctttc acatccattt ttattcccag atttctgacc 240 agcgtgacaa caggaaataa agtcatcagt tttgctggat gcttggttca atattttttt 300 gctatatttc ttggggcaac agagttttat ctcttggctt ctatgtccta tgaccgctat 360 gttgccatat gcaaacccct gcattatctg atcattatga gcaatcgggt ctgcatacaa 420 ctcgtgttct gttcctggct gggaggattc ctagctatct tacccccaat catcctgatg 480 agccaggtgg atttctgtgc ctccaatatt ctgaatcact attactgtga ttatgggccc 540 cttctggagc ttgcctgctc agacacaagc atcctagaag tgatggtcat cttcttggca 600 gttgtgactc tggtggttac tctactgctg gtgacatttt cttatacgta cattatcagg 660 accattttga ggatcccttc tgcccagcaa aggaaaaagg ctttttctac ttgttcttcc 720 cacatgattg tcatatccct ctcttatggc agctgcatgt ttatgtacat taatccctct 780 gcaaaagaag aaggttcttt caacaaagga atagctgtac tcattacctc aattactccg 840 ttgttaaacc ccttcattta tactctaaga aatcagcaag tgaagcaagc attcaaggat 900 gctgtcaaaa agattgtgaa gctttaa 927

<210> 2002 <211> 308 <212> PRT <213> Canis familiaris <400> 2002

Met Lys Asn Arg Thr Phe Thr Glu Phe Ile Leu Leu Gly Phe Thr Asn 1 5 10 15 Gln Pro Asp Ile Gln Val Val Ile Phe Ile Phe Leu Phe Ile Thr Tyr

20 25 30

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Ile Leu Ser 35 Val Leu Gly Asn 069269_0225_SL.TXT Leu Thr Ile Ile Ile Leu 40 45 Thr Leu Val Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe Ser 50 55 60 Phe Leu Glu Val Ser Phe Thr Ser Ile Phe Ile Pro Arg Phe Leu Thr 65 70 75 80 Ser Val Thr Thr Gly Asn Lys Val Ile Ser Phe Ala Gly Cys Leu Val 85 90 95 Gln Tyr Phe Phe Ala Ile Phe Leu Gly Ala Thr Glu Phe Tyr Leu Leu 100 105 110 Ala Ser Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His 115 120 125 Tyr Leu Ile Ile Met Ser Asn Arg Val Cys Ile Gln Leu Val Phe Cys 130 135 140 Ser Trp Leu Gly Gly Phe Leu Ala Ile Leu Pro Pro Ile Ile Leu Met 145 150 155 160 Ser Gln Val Asp Phe Cys Ala Ser Asn Ile Leu Asn His Tyr Tyr Cys 165 170 175 Asp Tyr Gly Pro Leu Leu Glu Leu Ala Cys Ser Asp Thr Ser Ile Leu 180 185 190 Glu Val Met Val Ile Phe Leu Ala Val Val Thr Leu Val Val Thr Leu 195 200 205 Leu Leu Val Thr Phe Ser Tyr Thr Tyr Ile Ile Arg Thr Ile Leu Arg 210 215 220 Ile Pro Ser Ala Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240

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His Met Ile Val Ile 245 Ser Leu 069269_0225_SL.TXT Ser Tyr Gly Ser Cys Met 250 Phe Met 255 Tyr Ile Asn Pro Ser Ala Lys Glu Glu Gly Ser Phe Asn Lys Gly Ile Ala 260 265 270 Val Leu Ile Thr Ser Ile Thr Pro Leu Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asp Ala Val Lys Lys 290 295 300

Ile Val Lys Leu 305 <210> 2003 <211> 942 <212> DNA <213> Canis familiaris <400> 2003

atggatataa caaaccaaac aagagtgaca gagttcattt ttcttgggtt tcctggtgtt 60 ctacatctgc ggatcacctt gtttgtgata tttcttactg tatatctact ctccctcaca 120 ggaaacactc tcattatttt cattgttctc atggatatca cactccaaac gcccatgtac 180 attttcttag gaaatttgtc attcctggag atctggtaca ccacagccac ggtgcctaaa 240 ttgctggaca cctgcctctc acaggttgtt accatctctg tttctggttg tatcacccag 300 tactacttct ttttctccat gggagctaca gagtgcatcc tgctggcagt gatggcctat 360 gatcggtacc tggccatctg cagcccttta agatactcac ttctcatgag tattcgtgtg 420 tgcctgcggt tttcagctgg atcttggatt gggggcttca ttgcccctct cttacctacc 480 atactcattt ctcatctaaa tttctgtggc ccccagaaga tcagccattt cttttgtgac 540 tcagacccca ttttcaaact ctcctgctca gatacatttt tggtggaggc tttgggctac 600 acatgtagct ctgttgtgat tctaagttct ttccttctca ccatgtcttc ctatggacac 660 atcgtggtca caataatcaa gctgtcttcc agggaggctc ggaagaaaac tttctccacc 720 tgtgcctccc acctcactgt ggtctctatc tattatggca ccattatctt tgcctatgtt 780

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069269_0225_SL.TXT cgccctccag ccaagtacaa tttcaccatt ggtaaagtga tatcagtgtt ctactgtgtg gttacccctt tggtaaatcc tctaatatat accctgagaa acaaagatgt gaagaaagct ttcagaaaag ctctagcaag aaagagaatg ctcttgacct ga

840

900

942 <210> 2004 <211> 313 <212> PRT <213> Canis familiaris <400> 2004

Met Asp 1 Ile Thr Asn Gln Thr Arg Val Thr Glu Phe Ile Phe Leu Gly 5 10 15 Phe Pro Gly Val Leu His Leu Arg Ile Thr Leu Phe Val Ile Phe Leu 20 25 30 Thr Val Tyr Leu Leu Ser Leu Thr Gly Asn Thr Leu Ile Ile Phe Ile 35 40 45 Val Leu Met Asp Ile Thr Leu Gln Thr Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Val Pro Lys 65 70 75 80 Leu Leu Asp Thr Cys Leu Ser Gln Val Val Thr Ile Ser Val Ser Gly 85 90 95 Cys Ile Thr Gln Tyr Tyr Phe Phe Phe Ser Met Gly Ala Thr Glu Cys 100 105 110 Ile Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Ser 115 120 125 Pro Leu Arg Tyr Ser Leu Leu Met Ser Ile Arg Val Cys Leu Arg Phe 130 135 140 Ser Ala Gly Ser Trp Ile Gly Gly Phe Ile Ala Pro Leu Leu Pro Thr 145 150 155 160

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Ile Leu Ile Ser His 165 Leu Asn Phe Cys Gly Pro Gln Lys Ile Ser His 170 175 Phe Phe Cys Asp Ser Asp Pro Ile Phe Lys Leu Ser Cys Ser Asp Thr 180 185 190 Phe Leu Val Glu Ala Leu Gly Tyr Thr Cys Ser Ser Val Val Ile Leu 195 200 205 Ser Ser Phe Leu Leu Thr Met Ser Ser Tyr Gly His Ile Val Val Thr 210 215 220 Ile Ile Lys Leu Ser Ser Arg Glu Ala Arg Lys Lys Thr Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ser Ile Tyr Tyr Gly Thr Ile Ile 245 250 255 Phe Ala Tyr Val Arg Pro Pro Ala Lys Tyr Asn Phe Thr Ile Gly Lys 260 265 270 Val Ile Ser Val Phe Tyr Cys Val Val Thr Pro Leu Val Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Lys Ala Phe Arg Lys Ala 290 295 300 Leu Ala Arg Lys Arg Met Leu Leu Thr

305 310 <210> 2005 <211> 939 <212> DNA <213> Canis familiaris <400> 2005 atggatctta aaaatggatc tgtagtgact gaatttattt tactaggatt ttctgggcaa cgggaatttc atattttctt ctttgtaaca ttcttgttaa tctacagtgc tactgtgtgg gggaatattc tcattatggt cacggtgaaa tttagttcca cccttcattc tcccatgtac Page 2252

120

180

069269_0225_SL.TXT ttcctccttg gaaacctctc ttttttagat atgtgtcttt ccactgtcac cacacccaaa atgatcacag acttgctcag tgaacacaaa accatctccg tatggggctg catgactcag atgttcttta tgcacttgtt tgggggtgct gagatgactc ttttgatagc catggccttt gacagatatg tagccatatg taaacccctg cactacagga caatcatgag ccacaggctg ctgagtgggt ttatgatact atcatggaca attggttttg tacacaccat gagccagatg gttttaacag tcaacttgcc tttctgtggc cccaatgtca tagacaatat attctgtgac cttcctcttg tgattcagct tgcttgtatg gacacatata caatggaatt ctttgtcatt gctgacagtg ggctgctctc actcatctgt tttatcctgc tgcttgtctc ctacactgtc atcctgatca ctgtacaaca aagatcatct ggaggactca acaaggctct gtccacactg tctgcacaca tcattgtggt cactctgttc tttggacctt gtatctttat ctatgcatgg ccattcaata gttttgcagg caataaagtc cttgctgtat tttacaccat tatcacaccc ttactgaatc ctgttattta cacactgaga aatcagaaaa tgcaaggagc aatgagaaaa ttatggttcc aacgtgtaat ttctacacag aagttttag <210> 2006 <211> 312 <212> PRT <213> Canis familiaris

240

300

360

420

480

540

600

660

720

780

840

900

939

<400> 2006 Met Asp Leu Lys 1 Asn 5 Gly Ser Val Val Thr Glu 10 Phe Ile Leu Leu 15 Gly Phe Ser Gly Gln Arg Glu Phe His Ile Phe Phe Phe Val Thr Phe Leu 20 25 30 Leu Ile Tyr Ser Ala Thr Val Trp Gly Asn Ile Leu Ile Met Val Thr 35 40 45 Val Lys Phe Ser Ser Thr Leu His Ser Pro Met Tyr Phe Leu Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Met Cys Leu Ser Thr Val Thr Thr Pro Lys 65 70 75 80

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Met Ile Thr Asp Leu 85 Leu Ser Glu His Lys Thr Ile Ser Val Trp Gly 90 95 Cys Met Thr Gln Met Phe Phe Met His Leu Phe Gly Gly Ala Glu Met 100 105 110 Thr Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Arg Thr Ile Met Ser His Arg Leu Leu Ser Gly Phe 130 135 140 Met Ile Leu Ser Trp Thr Ile Gly Phe Val His Thr Met Ser Gln Met 145 150 155 160 Val Leu Thr Val Asn Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Asn 165 170 175 Ile Phe Cys Asp Leu Pro Leu Val Ile Gln Leu Ala Cys Met Asp Thr 180 185 190 Tyr Thr Met Glu Phe Phe Val Ile Ala Asp Ser Gly Leu Leu Ser Leu 195 200 205 Ile Cys Phe Ile Leu Leu Leu Val Ser Tyr Thr Val Ile Leu Ile Thr 210 215 220 Val Gln Gln Arg Ser Ser Gly Gly Leu Asn Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Ile Ile Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Ala Trp Pro Phe Asn Ser Phe Ala Gly Asn Lys Val Leu Ala 260 265 270 Val Phe Tyr Thr Ile Ile Thr Pro Leu Leu Asn Pro Val Ile Tyr Thr 275 280 285

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Leu Arg Asn Gln Lys Met Gln Gly Ala Met Arg Lys Leu Trp Phe Gln 290 295 300

Arg Val Ile Ser Thr Gln Lys Phe

305 310 <210> 2007 <211> 891 <212> DNA <213> Canis familiaris <400> 2007

atggaaaggg caaaccattc agtggtatct gagttcattt tgctgggact ttccaaatct 60 cagaatcttc agattctgtt ctttgtaaga ttctctgtgg tctatgctgg gattgtgtta 120 ggaaacctaa ttttggtcac agtgaccttt gactcatgcc ttcacacaca aatgtacttt 180 ctgcttatca atatgtcctg tattgatatg atcctagctt cttttgctac ccctaagatt 240 attgtgggtt tcctccaaaa acagaagacc atctcttgtt ggggatgtta ttctcagatg 300 ctcttcatgt acctcctagg tgggaatgag atgatgttgc ttgtagccat ggcagtagac 360 aggtatattg ccatatgcaa acccctccat tacatgacca tcatgagccc gcaagtgctt 420 gttgggctgc tgttatcttc ctacgcagtt ggctttgtgc actggtctag tcaaatggct 480 ttcatgttga atttgccctt ctgtgtccca gtgtggtgga cagttttttc tgtgaccttc 540 ctcttgtgat caaacttgcc taccttctac aattgctggc cattgctgac agtggcctcc 600 tgtccctgat ctgcttcctc ctcttgcttg tctcctacac gatcatcata tactcagtca 660 ggcactatgc tgcctgtggt tcagccaagg ccttctccac tctgtcagca cacatcacag 720 ttgtcactgt cttctttgcc ccatgtgtct ttatctatgt atggcccttc agcagatatt 780 ctgtagataa aattctttcc gtgttttata caattatcaa ttatcacacc tctcttaaat 840 cctattattt atccattaag gaatcaagaa gtaaaagagc cataaagaag a 891

<210> 2008 <211> 182 <212> PRT <213> Canis familiaris

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<400> 2008 Met 1 Glu Arg Ala Asn His 5 Ser Val Val Ser 10 Glu Phe Ile Leu Leu 15 Gly Leu Ser Lys Ser Gln Asn Leu Gln Ile Leu Phe Phe Val Arg Phe Ser 20 25 30 Val Val Tyr Ala Gly Ile Val Leu Gly Asn Leu Ile Leu Val Thr Val 35 40 45 Thr Phe Asp Ser Cys Leu His Thr Gln Met Tyr Phe Leu Leu Ile Asn 50 55 60 Met Ser Cys Ile Asp Met Ile Leu Ala Ser Phe Ala Thr Pro Lys Ile 65 70 75 80 Ile Val Gly Phe Leu Gln Lys Gln Lys Thr Ile Ser Cys Trp Gly Cys 85 90 95 Tyr Ser Gln Met Leu Phe Met Tyr Leu Leu Gly Gly Asn Glu Met Met 100 105 110 Leu Leu Val Ala Met Ala Val Asp Arg Tyr Ile Ala Ile Cys Lys Pro 115 120 125 Leu His Tyr Met Thr Ile Met Ser Pro Gln Val Leu Val Gly Leu Leu 130 135 140 Leu Ser Ser Tyr Ala Val Gly Phe Val His Trp Ser Ser Gln Met Ala 145 150 155 160 Phe Met Leu Asn Leu Pro Phe Cys Val Pro Val Trp Trp Thr Val Phe 165 170 175 Ser Val Thr Phe Leu Leu

<210> 2009 <211> 621 <212> DNA

180

Page 2256

069269_0225_SL.TXT <213> Canis familiaris <400> 2009

atgggggcag ttgagatgtt cctacttata atgatggcct atgattggta tgttgcaatt 60 tgttgccctc tgcactataa cagtattata agtcaaggat tacgctgtat gttggtagct 120 gcctcctgga tgggagggtt tgtgcacact actgtccaga ttatcctcac tatccgttta 180 cctttttgtg gaccaaacaa ggtggacagc ttcttttgtg atgttgttcc ccctgttatc 240 aaacttgcct gcgcagacac atttgttatt gaattgctaa tggtatctaa cagtagatag 300 atctctaccg attcctctgt gatactgctt ttttcctatt ccactatcct ggccaagatt 360 ccctccaagg agggaaggtg aaaggcactt tcctcccgtg gcacccacgt catagtggta 420 acactcttct ttggaccctg tattttcatc tatgctcagc ccttttccac attttctgtg 480 gacaagatgg tgtctgtact ctacaatgct attacaccca taatgaatcc ccttatctac 540 acactttgga acaaaaaagt caagtcagcc atgcaaaaac tatgggacag gagtggactt 600 agttggaaaa agcaggagac a 621

<210> 2010 <211> 99 <212> PRT <213> Canis familiaris <400> 2010

Met Gly Ala Val Glu Met Phe Leu Leu Ile Met Met Ala Tyr Asp Trp 1 5 10 15 Tyr Val Ala Ile Cys Cys Pro Leu His Tyr Asn Ser Ile Ile Ser Gln 20 25 30 Gly Leu Arg Cys Met Leu Val Ala Ala Ser Trp Met Gly Gly Phe Val 35 40 45 His Thr Thr Val Gln Ile Ile Leu Thr Ile Arg Leu Pro Phe Cys Gly 50 55 60 Pro Asn Lys Val Asp Ser Phe Phe Cys Asp Val Val Pro Pro Val Ile 65 70 75 80

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Lys Leu Ala Cys Ala Asp Thr Phe Val Ile Glu Leu Leu Met Val Ser 85 90 95

Asn Ser Arg <210> 2011 <211> 267 <212> DNA <213> Canis familiaris <400> 2011 acagacacca tctattgagg catggttatt tgtactattt cttttcttct atgtgcccac 60 ttgggtaagc aatgttctca cttggtcaca gtggcctctg ataactatct gaattcatca 120 cctatgtatt tccttcttgg taacccctct ttcctggact tatgttattc aacagtaact 180 acccctgagc ttttggctga ctttcttgat aatgagaatc tcattggcta tgaccaatgt 240 attgtgtagc tcttctttct gcatttt 267 <210> 2012 <211> 36 <212> PRT <213> Canis familiaris <400> 2012

Gln Thr Pro Ser Ile Glu Ala Trp Leu Phe Val Leu Phe Leu Phe Phe 1 5 10 15 Tyr Val Pro Thr Trp Val Ser Asn Val Leu Thr Trp Ser Gln Trp Pro 20 25 30 Leu Ile Thr Ile 35

<210> 2013 <211> 819 <212> DNA <213> Canis familiaris <400> 2013 atggagggag gaaatgagat ggtaacaaca gatttcattc tctcaggact cttccccaat 60 gtgaagtatg tcagcatcct tatctacact atcatcctga tctacctggt tgccgtcact 120

Page 2258

069269_0225_SL.TXT gggaacttca tcctgctttt tcttatctgg atatacttga ggcttcacac cccaatgtac ttcctcctta gtcagctttc tctcgtagat ctggccttca tcagtagcac tgttccaaag atgataaact ttctctctgg aagaaaaaac atcacacatc ttgcctgtgg aacccagata tttttcttct ttactcttgg aggtgctgaa tgcatcctcc tgacccttat ggcctatgac tgatatgtat ctgtctgtca ccctttgaga tatgtagtga ttatgaacca aaaggtctgt ctgcaaatgg ccttccttct gtgattgcca gcaatcatga agatctcatg caaagacact tccacctatg agctggtggt cttcgttatg ggcattgctt ttatcattgt cccttttgga cttatcatgg cttcctacac tttcatcttc ctcactgttc ttcatatgag atccccccaa ggcaggacca aagccttggc cacatgctca tcccatctta cggtggtaag tttttatcta ggaccatgtg tttatatgta catgacacct ggtttcttcc acaccgttga gcaagaacag gctgtgtctg tattttgcac agtcctcaca cccatgctaa atccactcat ctacagcttg agaaacaaag atgtggtggg ggcttttcag aaaatcctg <210> 2014 <211> 121 <212> PRT <213> Canis familiaris <400> 2014

180

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819

Met 1 Lys Ile Ser Cys 5 Lys Asp Thr Ser Thr Tyr Glu Leu Val Val Phe 10 15 Val Met Gly Ile Ala Phe Ile Ile Val Pro Phe Gly Leu Ile Met Ala 20 25 30 Ser Tyr Thr Phe Ile Phe Leu Thr Val Leu His Met Arg Ser Pro Gln 35 40 45 Gly Arg Thr Lys Ala Leu Ala Thr Cys Ser Ser His Leu Thr Val Val 50 55 60 Ser Phe Tyr Leu Gly Pro Cys Val Tyr Met Tyr Met Thr Pro Gly Phe 65 70 75 80

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Phe His Thr Val Glu Gln Glu Gln Ala Val Ser Val Phe Cys Thr Val 85 90 95 Leu Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp 100 105 110 Val Val Gly Ala Phe Gln Lys Ile Leu 115 120

<210> 2015 <211> 873 <212> DNA <213> Canis familiaris <400> 2015

atgaccctgt ttgtggttgt gtctgtgttt tacacagtca ccctcgtggg caacagcacc 60 accatactcc tgtgtcacct ggatccccac ctccacaccc ccatgtactt cttcctcacc 120 cacccctcca tcctggacct ctgctttacc accagctgca tccctcagat gctggtcaat 180 ttctggggtt cagacaagac cataagctat ctgggatgcg cagcccagct ctacatcttc 240 ctgggactgg gagctgcaga gtgcatgctg ctgctggtca tggcctttga tcgctacttg 300 gtggtgtgcc gccctctgca ctatgcagtt attgtgaacc cacctctgtg tcacaagttg 360 gtatctctgg tctgggtcag tgaggttttt ggcacattgg tgcagtctcc cactaccatg 420 aaactcccct tttgccttca tcaccaggtt gacgactttg tctgtgaggt tcctgcactg 480 atacgcctgg cctgtggaga cacccacgtc aatgagctcc agatctcggt gattggtgtc 540 atcttcctga tggggacact gctgctcatc cttgtttcat acagccacat tgcccaagca 600 gtgctggcca tccagtccca ggaaggcagg agcaaggcct tccacacctg ctcttcccac 660 ctggcagtcg tctttctctt ctactgcagg gtcactgctg tctacatcca acctcggagt 720 cacttttcaa agaagggagg gaagttccta aatcttttct acaccatggt gacccccact 780 ctcaaccccc tcatctatac tttgaggaac aaggacatga agggagcttt caagaggctc 840 tttgggaaag acagaagggc cagtgaagaa tga 873

<210> 2016 <211> 290 <212> PRT

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069269_0225_SL.TXT <213> Canis familiaris <400> 2016

Met Thr Leu Phe Val Val Val Ser Val Phe Tyr Thr Val Thr Leu Val 1 5 10 15 Gly Asn Ser Thr Thr Ile Leu Leu Cys His Leu Asp Pro His Leu His 20 25 30 Thr Pro Met Tyr Phe Phe Leu Thr His Pro Ser Ile Leu Asp Leu Cys 35 40 45 Phe Thr Thr Ser Cys Ile Pro Gln Met Leu Val Asn Phe Trp Gly Ser 50 55 60 Asp Lys Thr Ile Ser Tyr Leu Gly Cys Ala Ala Gln Leu Tyr Ile Phe 65 70 75 80 Leu Gly Leu Gly Ala Ala Glu Cys Met Leu Leu Leu Val Met Ala Phe 85 90 95 Asp Arg Tyr Leu Val Val Cys Arg Pro Leu His Tyr Ala Val Ile Val 100 105 110 Asn Pro Pro Leu Cys His Lys Leu Val Ser Leu Val Trp Val Ser Glu 115 120 125 Val Phe Gly Thr Leu Val Gln Ser Pro Thr Thr Met Lys Leu Pro Phe 130 135 140 Cys Leu His His Gln Val Asp Asp Phe Val Cys Glu Val Pro Ala Leu 145 150 155 160 Ile Arg Leu Ala Cys Gly Asp Thr His Val Asn Glu Leu Gln Ile Ser 165 170 175 Val Ile Gly Val Ile Phe Leu Met Gly Thr Leu Leu Leu Ile Leu Val 180 185 190 Ser Tyr Ser His Ile Ala Gln Ala Val Leu Ala Ile Gln Ser Gln Glu

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195 069269_0225_SL.TXT 200 205 Gly Arg Ser Lys Ala Phe His Thr Cys Ser Ser His Leu Ala Val Val 210 215 220 Phe Leu Phe Tyr Cys Arg Val Thr Ala Val Tyr Ile Gln Pro Arg Ser 225 230 235 240 His Phe Ser Lys Lys Gly Gly Lys Phe Leu Asn Leu Phe Tyr Thr Met 245 250 255 Val Thr Pro Thr Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp 260 265 270 Met Lys Gly Ala Phe Lys Arg Leu Phe Gly Lys Asp Arg Arg Ala Ser

275 280 285

Glu Glu 290 <210> 2017 <211> 960 <212> DNA <213> Canis familiaris <400> 2017

atgagaggtg aaaaccagag cttcttgggg ggtcccccca aggacttcat ccttctaggt 60 gtttctgaca ggccatggct ggaactctct ctgtatgtgg tcctgctggt gtcctacctt 120 ctggccatgt tggggaacat tgccatcatc ctggtgtcca gactggaccc ccaactccac 180 agccctatgt acatttttct cagccacctc tccttcctgg acctctgtta caccaccacc 240 actgtcccac agatgctggt caacatgggc agcaccagga agaccatcag cttcggtggc 300 tgcacagtac agtatgcaat tttccactgg ctgggatgca ctgagtgcat tatcttggct 360 gccatggccc tggaccgcta cgtagccatc tgtgagccgc tgcagtatgc cattatcatg 420 taccaccctc tgtgccagaa gctcgtggct gtggcctggc tcagtggctt tggcaactcc 480 cttgttcagg tggtcctgac agtacagctg cctttctgcg ggaggcaggt gctgaacaac 540 ttcttctgtg aggtgccagc catgatcaag ctgtcgtgtg ctgacaccac catgaacgat 600

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gccatgctgg ctgtacttgt ggccttcttc gtgctggtgc ccctagctct cattcttctc 660 tcctatggct tcattgcacg cgcggtgctc aggatccagt cctcccgggg aaggcgcaaa 720 tccttcggga cttgttcctc tcacctggtg gtggtctccc tcttctacct gcctgccatc 780 tacatgtact tacagtcccc ttccagctac tcccaagagc agggtaagtt tatctccctc 840 ttctattcca taatcacccc caccctcaat ccctttatct acaccctgag gaataaggat 900 gtgaaaagag ctctaaggag actcctgtca aggacctgga ggttttgcag gaggctctga 960

<210> 2018 <211> 319 <212> PRT <213> Canis familiaris <400> 2018

Met Arg Gly Glu Asn Gln Ser Phe Leu Gly Gly Pro Pro Lys Asp Phe 1 5 10 15 Ile Leu Leu Gly Val Ser Asp Arg Pro Trp Leu Glu Leu Ser Leu Tyr 20 25 30 Val Val Leu Leu Val Ser Tyr Leu Leu Ala Met Leu Gly Asn Ile Ala 35 40 45 Ile Ile Leu Val Ser Arg Leu Asp Pro Gln Leu His Ser Pro Met Tyr 50 55 60 Ile Phe Leu Ser His Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Thr 65 70 75 80 Thr Val Pro Gln Met Leu Val Asn Met Gly Ser Thr Arg Lys Thr Ile 85 90 95 Ser Phe Gly Gly Cys Thr Val Gln Tyr Ala Ile Phe His Trp Leu Gly 100 105 110 Cys Thr Glu Cys Ile Ile Leu Ala Ala Met Ala Leu Asp Arg Tyr Val 115 120 125

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Ala Ile 130 Cys Glu Pro Leu Gln 135 069269_0225_SL.TXT Tyr Ala Ile Ile Met Tyr 140 His Pro Leu Cys Gln Lys Leu Val Ala Val Ala Trp Leu Ser Gly Phe Gly Asn Ser 145 150 155 160 Leu Val Gln Val Val Leu Thr Val Gln Leu Pro Phe Cys Gly Arg Gln 165 170 175 Val Leu Asn Asn Phe Phe Cys Glu Val Pro Ala Met Ile Lys Leu Ser 180 185 190 Cys Ala Asp Thr Thr Met Asn Asp Ala Met Leu Ala Val Leu Val Ala 195 200 205 Phe Phe Val Leu Val Pro Leu Ala Leu Ile Leu Leu Ser Tyr Gly Phe 210 215 220 Ile Ala Arg Ala Val Leu Arg Ile Gln Ser Ser Arg Gly Arg Arg Lys 225 230 235 240 Ser Phe Gly Thr Cys Ser Ser His Leu Val Val Val Ser Leu Phe Tyr 245 250 255 Leu Pro Ala Ile Tyr Met Tyr Leu Gln Ser Pro Ser Ser Tyr Ser Gln 260 265 270 Glu Gln Gly Lys Phe Ile Ser Leu Phe Tyr Ser Ile Ile Thr Pro Thr 275 280 285 Leu Asn Pro Phe Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Arg Ala 290 295 300 Leu Arg Arg Leu Leu Ser Arg Thr Trp Arg Phe Cys Arg Arg Leu 305 310 315

<210> 2019 <211> 228 <212> DNA <213> Canis familiaris

Page 2264

069269_0225_SL.TXT <400> 2019 acctgtacca tagtacccca gctgctggcc aatctcgggg ggccagagaa gacaattgct 60 tcctggggct gcatcaccca ggcctatctc ttccactgga caggatgcac tgaatatacc 120 ctgttggcag taatggcttt tgatcactat gtggctattt acaggcctct ccagtacact 180 ctcatcatgc agccccaggt gtgtgtgcaa ctggcaggtg ctgcctgg 228 <210> 2020 <211> 76 <212> PRT <213> Canis familiaris

<400> 2020 Thr Cys Thr Ile 1 Val 5 Pro Gln Leu Leu Ala Asn Leu Gly Gly Pro Glu 10 15 Lys Thr Ile Ala Ser Trp Gly Cys Ile Thr Gln Ala Tyr Leu Phe His 20 25 30 Trp Thr Gly Cys Thr Glu Tyr Thr Leu Leu Ala Val Met Ala Phe Asp 35 40 45 His Tyr Val Ala Ile Tyr Arg Pro Leu Gln Tyr Thr Leu Ile Met Gln 50 55 60 Pro Gln Val Cys Val Gln Leu Ala Gly Ala Ala Trp 65 70 75

<210> 2021 <211> 945 <212> DNA <213> Canis familiaris <400> 2021 atggcaagag acaatgacag ctaccagcaa gtattcatct tggtgggctt ttctgaccgt 60 cctcaactag agataattct ctttgctttt gtcttggtct tctacatcct gaccctcttg 120 ggcaacagtg ccatcatctt cttgtcaatc ttggatgcca ggctccacac acccatgtac 180 ttctttcttg ggaacctttc ttttttggac ctctgcttta cgacgagcat tgtcccccag 240 ttgctgtgga acctttgggg tccagagaag accatcacct accatggttg tgtggcccag 300

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ctctacatct acatggtgtt gggctcaacc gagtgtgttc tcctagctgt catgtcctat 360 gaccgctacg tggctgtctg ccggcccctg cactacactg tgatcatgca tccacgtctc 420 tgcctgcagt tggtgactgt gtcctggttc tgtggctttc taaattcctt tgtcatgtgt 480 ccccagacca tgcaactctc ccgatgtggg caccatatgg tggaccactt tctgtgtgag 540 atgcctgctc ttattgccat gtcctgtgaa gacaccatgc tggtggaagc atttgccttt 600 gccctgggtg ttgcccttct cctggtgccc ctttccctga tcctcatctc ttacagcatg 660 attgcagcca ctgtgctgag gatcaagtca gcagcagggt gcaagaaagc tttcaacacc 720 tgctcttccc acctgatggt ggtctccctt ttctacggga ccatcatcta catgtacctg 780 cagcccgcca atagctactc ccaagaccaa ggcaagttcc tcaccctctt ctacaccatc 840 atcactccca gtatcaaccc cctgatctac acgctgagga acaaggatgt aaagggggtg 900 atgaggaggc tcctgaaggg tgagaagggg gccagggaag cctaa 945

<210> 2022 <211> 314 <212> PRT <213> Canis familiaris

<400> 2022 Asn Asp 5 Ser Tyr Gln Gln Val Phe Ile Leu Val Gly Met Ala 1 Arg Asp 10 15 Phe Ser Asp Arg Pro Gln Leu Glu Ile Ile Leu Phe Ala Phe Val Leu 20 25 30 Val Phe Tyr Ile Leu Thr Leu Leu Gly Asn Ser Ala Ile Ile Phe Leu 35 40 45 Ser Ile Leu Asp Ala Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Ile Val Pro Gln 65 70 75 80 Leu Leu Trp Asn Leu Trp Gly Pro Glu Lys Thr Ile Thr Tyr His Gly 85 90 95

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Cys Val Ala Gln 100 Leu Tyr Ile Tyr Met Val Leu Gly Ser Thr Glu Cys 105 110 Val Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Arg 115 120 125 Pro Leu His Tyr Thr Val Ile Met His Pro Arg Leu Cys Leu Gln Leu 130 135 140 Val Thr Val Ser Trp Phe Cys Gly Phe Leu Asn Ser Phe Val Met Cys 145 150 155 160 Pro Gln Thr Met Gln Leu Ser Arg Cys Gly His His Met Val Asp His 165 170 175 Phe Leu Cys Glu Met Pro Ala Leu Ile Ala Met Ser Cys Glu Asp Thr 180 185 190 Met Leu Val Glu Ala Phe Ala Phe Ala Leu Gly Val Ala Leu Leu Leu 195 200 205 Val Pro Leu Ser Leu Ile Leu Ile Ser Tyr Ser Met Ile Ala Ala Thr 210 215 220 Val Leu Arg Ile Lys Ser Ala Ala Gly Cys Lys Lys Ala Phe Asn Thr 225 230 235 240 Cys Ser Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Tyr Met Tyr Leu Gln Pro Ala Asn Ser Tyr Ser Gln Asp Gln Gly Lys 260 265 270 Phe Leu Thr Leu Phe Tyr Thr Ile Ile Thr Pro Ser Ile Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly Val Met Arg Arg Leu 290 295 300

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Leu Lys Gly Glu Lys Gly Ala Arg Glu Ala 305 310 <210> 2023 <211> 858 <212> DNA <213> Canis familiaris <400> 2023

aaactggaga tggttctgtt tttcattaac atggtttttt accttctggc catcaagggc 60 aactcgagca tcatcttcct ctcagtgatg gactctcgac tgcacgtgcc catgtacttc 120 ttcttctgca atctttccct cctggacatg tgctacacca ctagcagcat tccccagata 180 ctgatcaacc tgtggggctc aagcaagacc atcacctacg tgggttgtgt catccagctc 240 tctgccttcc tgtctgtagg aggcacggag tgcattctcc tgtctataat ggcctatgac 300 cgttttgtgg ccgtctgcaa gccactgcac tacatggcca tcatgcaccc ccagctatgc 360 ctgcagctgg cggcctttgg atggctcagt gggatggtca actccatcct catgtcccca 420 ctgatgatgt ccctgggcct ctgtggtcag cgccgcatca cccactttgt gtgtgagatg 480 tcagccatca tccgcatctc gtgcatggac accagacatg tggaaggcct ggctttcttc 540 ctggccatcc ccatcgtgct agtgcctctc tccacaatcc tcgtgtccta cagctacatt 600 gccgtcaagg ttgcgggcat ccggtctgca gctggcagac gcaaggcctt caacacctgc 660 tcatcccaca tggcgctggt gtccctcttc tacagcagca gcatctccat gtaaatgcag 720 cctgggaatg tagaaagcca ggaccagggc tagtttctta ctctgttcta ccgtctggca 780 acccccaccc tgaatccttt catctacatg ctgagaaaca aagacgtgca gggggcaatg 840 tggaaggtgc tggggaga 858

<210> 2024 <211> 237 <212> PRT <213> Canis familiaris <400> 2024

Lys Leu Glu Met Val Leu Phe Phe Ile Asn Met Val Phe Tyr Leu Leu 1 5 10 15

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Ala Ile Lys Gly Asn Ser 20 Ser Ile Ile Phe Leu Ser Val Met Asp Ser 25 30 Arg Leu His Val Pro Met Tyr Phe Phe Phe Cys Asn Leu Ser Leu Leu 35 40 45 Asp Met Cys Tyr Thr Thr Ser Ser Ile Pro Gln Ile Leu Ile Asn Leu 50 55 60 Trp Gly Ser Ser Lys Thr Ile Thr Tyr Val Gly Cys Val Ile Gln Leu 65 70 75 80 Ser Ala Phe Leu Ser Val Gly Gly Thr Glu Cys Ile Leu Leu Ser Ile 85 90 95 Met Ala Tyr Asp Arg Phe Val Ala Val Cys Lys Pro Leu His Tyr Met 100 105 110 Ala Ile Met His Pro Gln Leu Cys Leu Gln Leu Ala Ala Phe Gly Trp 115 120 125 Leu Ser Gly Met Val Asn Ser Ile Leu Met Ser Pro Leu Met Met Ser 130 135 140 Leu Gly Leu Cys Gly Gln Arg Arg Ile Thr His Phe Val Cys Glu Met 145 150 155 160 Ser Ala Ile Ile Arg Ile Ser Cys Met Asp Thr Arg His Val Glu Gly 165 170 175 Leu Ala Phe Phe Leu Ala Ile Pro Ile Val Leu Val Pro Leu Ser Thr 180 185 190 Ile Leu Val Ser Tyr Ser Tyr Ile Ala Val Lys Val Ala Gly Ile Arg 195 200 205 Ser Ala Ala Gly Arg Arg Lys Ala Phe Asn Thr Cys Ser Ser His Met 210 215 220

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Ala Leu Val Ser Leu Phe Tyr Ser Ser Ser Ile Ser Met 225 230 235 <210> 2025 <211> 966 <212> DNA <213> Canis familiaris <400> 2025

atgatgatgg gaatagccaa tgtaagttct ccagaagtct ttgtactcct gggcttctct 60 gcacgaccct ccctagaatc catcctcttc atcattgtct tagggtttta cgtggtgtct 120 atcttgggca atggcatcat cattctggtt tcctgcatgg atgtgcacct ccacacgcct 180 atgtacttct ttcttgctaa cctctccttc cttgacatta gctttaccac aagcattgtc 240 ccacaacttc tggtcaacct ctggggacca cagaaaacca taagctacgg agggtgtgtg 300 gtccaattct atatctccca ctggctggga gcgactgaat gtgtcttctt ggcagtcatg 360 tcctacgacc gctatgctgc catctgtagg ccacttaatt acaccatcat catgcatcca 420 cagctttgcc tcagcttggc cctcgcctca tggcttgggg gtctgaccac cagcatggtg 480 ggctccacac tcactatgct cctgccgctc tgtgggaaca atcgcattga tcacttcttc 540 tgtgagatgc ccctcattat gcaattgact tgcgtggaca ccagcctcaa tgaggtggag 600 atgtatgtgg ccagctttat ctttgttgtc ttgcccctgg gtctcatcct ggtctcatat 660 ggccacattg cctgggctgt gatgaagatc aggtcagcag aaggacggag aaaggccttc 720 aacacttgct cctcccatgt ggcagttgtg gctctattct atgggagcat catctttatg 780 tatctccagc cagccaagag taactcccat gaacagggca agttcatagc cctcttctac 840 actgtgatca ccccgatgct gaatcccttg atttacacgc tcaggaacaa ggatgtgaag 900 acggctctca ggcacattgt gttagagaag tgctgtggct ttgcagggcc atgggggcat 960

atttag 966 <210> 2026 <211> 321 <212> PRT <213> Canis familiaris <400> 2026

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Met 1 Met Met Gly Ile 5 Ala Asn Val Ser Ser Pro Glu Val Phe Val Leu 10 15 Leu Gly Phe Ser Ala Arg Pro Ser Leu Glu Ser Ile Leu Phe Ile Ile 20 25 30 Val Leu Gly Phe Tyr Val Val Ser Ile Leu Gly Asn Gly Ile Ile Ile 35 40 45 Leu Val Ser Cys Met Asp Val His Leu His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ala Asn Leu Ser Phe Leu Asp Ile Ser Phe Thr Thr Ser Ile Val 65 70 75 80 Pro Gln Leu Leu Val Asn Leu Trp Gly Pro Gln Lys Thr Ile Ser Tyr 85 90 95 Gly Gly Cys Val Val Gln Phe Tyr Ile Ser His Trp Leu Gly Ala Thr 100 105 110 Glu Cys Val Phe Leu Ala Val Met Ser Tyr Asp Arg Tyr Ala Ala Ile 115 120 125 Cys Arg Pro Leu Asn Tyr Thr Ile Ile Met His Pro Gln Leu Cys Leu 130 135 140 Ser Leu Ala Leu Ala Ser Trp Leu Gly Gly Leu Thr Thr Ser Met Val 145 150 155 160 Gly Ser Thr Leu Thr Met Leu Leu Pro Leu Cys Gly Asn Asn Arg Ile 165 170 175 Asp His Phe Phe Cys Glu Met Pro Leu Ile Met Gln Leu Thr Cys Val 180 185 190 Asp Thr Ser Leu Asn Glu Val Glu Met Tyr Val Ala Ser Phe Ile Phe 195 200 205

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Val Val Leu Pro Leu Gly Leu Ile 215 Leu Val Ser Tyr Gly His Ile Ala 220 210 Trp Ala Val Met Lys Ile Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe 225 230 235 240 Asn Thr Cys Ser Ser His Val Ala Val Val Ala Leu Phe Tyr Gly Ser 245 250 255 Ile Ile Phe Met Tyr Leu Gln Pro Ala Lys Ser Asn Ser His Glu Gln 260 265 270 Gly Lys Phe Ile Ala Leu Phe Tyr Thr Val Ile Thr Pro Met Leu Asn 275 280 285 Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Thr Ala Leu Arg 290 295 300 His Ile Val Leu Glu Lys Cys Cys Gly Phe Ala Gly Pro Trp Gly His 305 310 315 320

Ile <210> 2027 <211> 885 <212> DNA <213> Canis familiaris <400> 2027

atggaaaagg ccaatgtgag ctccttgatg ggtttcatcc ttctaggctt ctcagaccac 60 cctcacctgg aagctgcact ctttgtattt gtcctttttt tctacctcct gactcttgtg 120 gggaacctca ctatcatcat tatctcatac ctacatcccc tcctccacac ccctatgtac 180 ttcttcctca gcaacctctc cctgctggac ctctgcttca ctactagcct tgcacctcag 240 atgctagtta acctgagagg tccagagaag actatcactt atggtggttg tgtagtacaa 300 ctctatattt cgctagcact gggctccact gagtgtatcc tcctggctgt aatggctttg 360 gatcactatg ttgccatctg caagcccctt cactatgtgg ctatcatgaa cccaaggcta 420

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tgtcaacagc tggcatccat ctcctggttt agtggtttgg ccaattcgct gatccatgct 480 actattacct tgcaattgcc tctatgtggc aaccacagac tcgatcattt tatttgtgaa 540 gtgccagctc tcctcaagtt ggcttgtgtg gacaccactg tcaacacacc actgtcaact 600 attggtgctt ttttggttag tgtcctgttt ctcctaatac ccccaacact cattcttatc 660 tcctatggct ttattagtca agctgtgctg aagataaagt cagtggaggc aaggcacaaa 720 gcctgcagca cctgctcctc ccaccttaca gtggtgatca ttttctatgg caccataatc 780 tacatgtacc tgcaaccaag gaacagctgt actcagaacc aaggcaaatt tatctcccac 840 ttctatacca tggtgactcc aaccttaaat cctattatct acact 885 <210> 2028 <211> 295 <212> PRT <213> Canis familiaris <400> 2028 Met Glu Lys Ala Asn Val Ser Ser Leu Met Gly Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asp His Pro His Leu Glu Ala Ala Leu Phe Val Phe Val Leu 20 25 30 Phe Phe Tyr Leu Leu Thr Leu Val Gly Asn Leu Thr Ile Ile Ile Ile 35 40 45 Ser Tyr Leu His Pro Leu Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Leu Leu Asp Leu Cys Phe Thr Thr Ser Leu Ala Pro Gln 65 70 75 80 Met Leu Val Asn Leu Arg Gly Pro Glu Lys Thr Ile Thr Tyr Gly Gly 85 90 95 Cys Val Val Gln Leu Tyr Ile Ser Leu Ala Leu Gly Ser Thr Glu Cys 100 105 110 Ile Leu Leu Ala Val Met Ala Leu Asp His Tyr Val Ala Ile Cys Lys

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115 069269_0225_SL.TXT 120 125 Pro Leu His Tyr Val Ala Ile Met Asn Pro Arg Leu Cys Gln Gln Leu 130 135 140 Ala Ser Ile Ser Trp Phe Ser Gly Leu Ala Asn Ser Leu Ile His Ala 145 150 155 160 Thr Ile Thr Leu Gln Leu Pro Leu Cys Gly Asn His Arg Leu Asp His 165 170 175 Phe Ile Cys Glu Val Pro Ala Leu Leu Lys Leu Ala Cys Val Asp Thr 180 185 190 Thr Val Asn Thr Pro Leu Ser Thr Ile Gly Ala Phe Leu Val Ser Val 195 200 205 Leu Phe Leu Leu Ile Pro Pro Thr Leu Ile Leu Ile Ser Tyr Gly Phe 210 215 220 Ile Ser Gln Ala Val Leu Lys Ile Lys Ser Val Glu Ala Arg His Lys 225 230 235 240 Ala Cys Ser Thr Cys Ser Ser His Leu Thr Val Val Ile Ile Phe Tyr 245 250 255 Gly Thr Ile Ile Tyr Met Tyr Leu Gln Pro Arg Asn Ser Cys Thr Gln 260 265 270 Asn Gln Gly Lys Phe Ile Ser His Phe Tyr Thr Met Val Thr Pro Thr 275 280 285

Leu Asn Pro Ile Ile Tyr Thr 290 295 <210> 2029 <211> 960 <212> DNA <213> Canis familiaris

Page 2274

069269_0225_SL.TXT <400> 2029

atggatataa caaaccaaac aagagtgaca gagttcattt ttcttgggtt ccctggtgtt 60 ctacatctgc ggatcacctt gtttgtgata tttcttattg tatatctgct ctccctcgtg 120 ggaaacattc ttatcatttt cattgttgtg ttagattcca cactccaaat gcccatgtac 180 attttcttag gaaatttgtc attcctggag atctggtaca ccacagccac gatgcctaaa 240 ttactggaca cctgcctctc acagactgtt accatctctg tttctggttg tatcacccag 300 tactacttct ttttctccat gggagctaca gagtgcatcc tgctggcagt gatggcctat 360 gatcggtacc tggccatatg cagtcctctc cattattcac tcctcatgag tatccatatc 420 tgtctgtggt tttcagctgg atcttggatt gggggattca cttcccctct cctgtctact 480 atactcatct cacatctcaa cttttgtggg cctcagaaga ttaaccattt cttttgtgac 540 tcagacccca ttttcaaact ctcttgctca gatacatttt tggcagaggc cttgagctac 600 acatgtagct ctgttgtgat tctaagttct ttccttctca ctatgtcttc ctatggacac 660 atcatagtca cagtaatgag actgccttcc cgtgaggctt ggaagaaagc attatccact 720 tgcacctccc acctcactgt ggtctctatc tattatggca ccattatctt tgcttatgtt 780 cgccctccag ccaagtacaa cttcactatt ggtaaattaa tctcagtgtt ctactgtgtg 840 gtcactccat tgataaatcc tctcatttac accctgagaa acaaagaggt gaagaaagct 900 ttcaggaagg ttctagctca aaaaagattt ctcttgttca gatacatgca agaaatttga 960

<210> 2030 <211> 319 <212> PRT <213> Canis familiaris <400> 2030

Met 1 Asp Ile Thr Asn Gln Thr Arg Val Thr Glu Phe Ile Phe Leu Gly 5 10 15 Phe Pro Gly Val Leu His Leu Arg Ile Thr Leu Phe Val Ile Phe Leu 20 25 30 Ile Val Tyr Leu Leu Ser Leu Val Gly Asn Ile Leu Ile Ile Phe Ile 35 40 45

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Val Val 50 Leu Asp Ser Thr Leu 55 069269_0225_SL.TXT Gln Met Pro Met Tyr Ile 60 Phe Leu Gly Asn Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Met Pro Lys 65 70 75 80 Leu Leu Asp Thr Cys Leu Ser Gln Thr Val Thr Ile Ser Val Ser Gly 85 90 95 Cys Ile Thr Gln Tyr Tyr Phe Phe Phe Ser Met Gly Ala Thr Glu Cys 100 105 110 Ile Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Ser 115 120 125 Pro Leu His Tyr Ser Leu Leu Met Ser Ile His Ile Cys Leu Trp Phe 130 135 140 Ser Ala Gly Ser Trp Ile Gly Gly Phe Thr Ser Pro Leu Leu Ser Thr 145 150 155 160 Ile Leu Ile Ser His Leu Asn Phe Cys Gly Pro Gln Lys Ile Asn His 165 170 175 Phe Phe Cys Asp Ser Asp Pro Ile Phe Lys Leu Ser Cys Ser Asp Thr 180 185 190 Phe Leu Ala Glu Ala Leu Ser Tyr Thr Cys Ser Ser Val Val Ile Leu 195 200 205 Ser Ser Phe Leu Leu Thr Met Ser Ser Tyr Gly His Ile Ile Val Thr 210 215 220 Val Met Arg Leu Pro Ser Arg Glu Ala Trp Lys Lys Ala Leu Ser Thr 225 230 235 240 Cys Thr Ser His Leu Thr Val Val Ser Ile Tyr Tyr Gly Thr Ile Ile 245 250 255

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Phe Ala Tyr Val Arg Pro Pro Ala Lys Tyr Asn Phe Thr Ile Gly Lys 260 265 270

Leu Ile Ser Val Phe Tyr Cys Val Val Thr Pro Leu Ile Asn Pro Leu 275 280 285

Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Lys Ala Phe Arg Lys Val 290 295 300

Leu Ala Gln Lys Arg Phe Leu Leu Phe Arg Tyr Met Gln Glu Ile 305 310 315 <210> 2031 <211> 930 <212> DNA <213> Canis familiaris <400> 2031 atgagaaacc acaccactgt cactgagttt ctgcagatgc tcatcttcct ggcactgctc ctcctcattg tgagcatcac cctcatagac ctctgcaact ttgctgtcct ggagatctgg accaacatcc taactggaaa caagaccatt ctctatttct tcctgggcac tacagagttc tatgtggcca tatgtaaccc cttgcgttat cagctagttc tttgttcctg gatggcagga acttttcagc agccattttg tggccccaat ccactcctgg agctcatatg tgcagacaca gccaacttca gtttactggg cactctgtcc cacagcatcc tgcgcatccc ttcagccaag tctcacatta ttgttgtgtc tctcttctat gggaagggta atgagggaga ggacaaaaac accccaatgc tcaatccctt catctatacc gtcctgctag ctgacctatc aggtgcctcc ttcacctcgg tccctagcag ttcctactag gccaccatca ttccttctca gtcattaatc agtctgatag gtgacaacca gaaaggcaga ggcagctgca aaggtggtag ctaaggaaca

ggctctcaga ggcctgtgag 60 ttgtcactct gctaggaaat 120 acacccccat gtactacttc 180 tcatcttccc caagatgctg 240 gctgttttct acaaagtttc 300 cagcgatgtc ctttgacagg 360 tgagcaaaag ggtctgtgtc 420 tcatctttcc aagtttcatc 480 atttcttctg tgacaacttt 540 agcttctggg ctttattgtg 600 cctgctatgg ctacatcctc 660 aagccttctc aacctgctcc 720 tcttcatgta catccgggca 780 ccttgctcaa taccgtggtg 840 aacaggtgaa gcaggtgttt 900

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930

069269_0225_SL.TXT aggaagcaaa tgagcaagct cctttcataa <210> 2032 <211> 309 <212> PRT <213> Canis familiaris

<400> 2032 Met 1 Arg Asn His Thr 5 Thr Val Thr Glu Phe 10 Val Leu Leu Gly Leu 15 Ser Glu Ala Cys Glu Leu Gln Met Leu Ile Phe Leu Ala Leu Leu Leu Thr 20 25 30 Tyr Leu Val Thr Leu Leu Gly Asn Leu Leu Ile Val Ser Ile Thr Leu 35 40 45 Ile Asp Arg Cys Leu His Thr Pro Met Tyr Tyr Phe Leu Cys Asn Phe 50 55 60 Ala Val Leu Glu Ile Trp Phe Thr Ser Val Ile Phe Pro Lys Met Leu 65 70 75 80 Thr Asn Ile Leu Thr Gly Asn Lys Thr Ile Ser Leu Ala Gly Cys Phe 85 90 95 Leu Gln Ser Phe Leu Tyr Phe Phe Leu Gly Thr Thr Glu Phe Phe Leu 100 105 110 Leu Ala Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 115 120 125 Arg Tyr Ala Thr Ile Met Ser Lys Arg Val Cys Val Gln Leu Val Leu 130 135 140 Cys Ser Trp Met Ala Gly Phe Leu Leu Ile Ile Phe Pro Ser Phe Ile 145 150 155 160 Thr Phe Gln Gln Pro Phe Cys Gly Pro Asn Val Ile Asn His Phe Phe 165 170 175

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Cys Asp Asn Phe Pro Leu Leu Glu Leu Ile Cys Ala Asp Thr Ser Leu 180 185 190 Ile Glu Leu Leu Gly Phe Ile Val Ala Asn Phe Ser Leu Leu Gly Thr 195 200 205 Leu Ser Val Thr Thr Thr Cys Tyr Gly Tyr Ile Leu His Ser Ile Leu 210 215 220 Arg Ile Pro Ser Ala Lys Glu Arg Gln Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Ile Ile Val Val Ser Leu Phe Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Arg Ala Gly Lys Gly Asn Glu Gly Glu Asp Lys Asn Lys Val 260 265 270 Val Ala Leu Leu Asn Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Gln Val Lys Gln Val Phe Arg Lys Gln Met 290 295 300 Ser Lys Leu Leu Ser

305 <210> 2033 <211> 603 <212> DNA <213> Canis familiaris <400> 2033 attatttttg gatgtttgga caatctgctt ctgactgtga tggcttctaa ccagtttgtg gtcatatgtt accccctgca ctatccagtc atcatgaatt accacctttg tggcttttta ggtttggtat ctttcttcag tcagcgtttc aggatcccag ctgcacagtt ggatgatatc acaacttaca ttctgcaaaa atatagaaat tcattatttc tcttgtgact cttctcacct tctcaacctt ggcttttcta gcatccacac caataacata ttattatatt tattggtgct

120

180

240

300

Page 2279

069269_0225_SL.TXT gtattttgta gtactctatt ttcaatggtc cttaactctt acaccttaaa tagcctcttc cagtattgcg agtaccatca gcagttcaga aatatggagc cttctccatc tgaagttctc atcagcttgc ttattttatg gaacaggcct tgggagctgc ttagtttatc tcagtgttcc cccagaaagg gtacagtggc ctccgtggtg tgtactgtga tcactcccat gctgaatcac ttcatctaca gcctgaggaa atgggatttc aagagtgcac tgtggaggcc cttcagcaga aca <210> 2034 <211> 93 <212> PRT <213> Canis familiaris

<400> 2034 Ser Tyr 5 Thr Leu Asn Ser Leu Phe Gln Tyr Cys Glu Met Val 1 Leu Asn 10 15 Tyr His Gln Gln Phe Arg Asn Met Glu Pro Ser Pro Ser Glu Val Leu 20 25 30 Ile Ser Leu Leu Ile Leu Trp Asn Arg Pro Trp Glu Leu Leu Ser Leu 35 40 45 Ser Gln Cys Ser Pro Arg Lys Gly Thr Val Ala Ser Val Val Cys Thr 50 55 60 Val Ile Thr Pro Met Leu Asn His Phe Ile Tyr Ser Leu Arg Lys Trp 65 70 75 80 Asp Phe Lys Ser Ala Leu Trp Arg Pro Phe Ser Arg Thr 85 90

<210> 2035 <211> 942 <212> DNA <213> Canis familiaris <400> 2035 atggaagcac agaacatcac acaagtgttc cagtttgtcc ttttaggatt ttcacagacc

360

420

480

540

600

603

Page 2280

069269_0225_SL.TXT

caggagctcc agaaattcct gttcctggtg ttcttatttg tctatgtcac caccattgtg 120 ggaaacatcc ttatcatagt tacagtgact tctgactctc ggctccacac gcccatgtat 180 tttctgctcc gaaatctggc tgtcatagat ctctgctatt ccacagtcac ttctccaaag 240 atgctggtgg acttctttca tgaggtccgg accatctcct accagggctg catggcccag 300 atcttcttct ttcacctctt gggtggtggg actgtcttct tcctttcagt aatggcctat 360 gaccgctaca tagccatctc ccggcccctc cactatgtca ccatcatgaa ccctcgattg 420 tgtgtggggc tggtggtggc tgcttgggta gggggatttg ttcactccat tgtccagctt 480 gctctgatgc tcccgttacc tttttgtggc cccaacatcc tggataactt ctactgtgat 540 gtcccacaac tgctgagact cgcctgtact gatacctccc ttctggagtt cctcatgatc 600 tccaacagtg ggatgttagt tctcatctgg ttccttctcc ttctgatatc ttacacggtc 660 atcctggtga tgctgaggtc ccactcaggg caagccaaga agaaggcagc ttccacatgt 720 accactcaca tcattgtggt gtctatgatc ttcattccct gtatctatat ctactcccgg 780 cccttcactc ctttccccat ggacaaggct gtgtccatca gctacacagt tatgaccccc 840 atgctcaacc ccatgatcta taccctgagg aatcaggaga tgcaggcagc catgaagaga 900 ttaggcaagc gcctcatggt atgtaacaga gagtggactt aa 942 <210> 2036 <211> 313 <212> PRT <213> Canis familiaris <400> 2036 Met Glu Ala Gln Asn Ile Thr Gln Val Phe Gln Phe Val Leu Leu Gly 1 5 10 15 Phe Ser Gln Thr Gln Glu Leu Gln Lys Phe Leu Phe Leu Val Phe Leu 20 25 30 Phe Val Tyr Val Thr Thr Ile Val Gly Asn Ile Leu Ile Ile Val Thr 35 40 45 Val Thr Ser Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60

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Asn 65 Leu Ala Val Ile Asp Leu Cys Tyr Ser Thr Val Thr Ser Pro Lys 70 75 80 Met Leu Val Asp Phe Phe His Glu Val Arg Thr Ile Ser Tyr Gln Gly 85 90 95 Cys Met Ala Gln Ile Phe Phe Phe His Leu Leu Gly Gly Gly Thr Val 100 105 110 Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Ser Arg 115 120 125 Pro Leu His Tyr Val Thr Ile Met Asn Pro Arg Leu Cys Val Gly Leu 130 135 140 Val Val Ala Ala Trp Val Gly Gly Phe Val His Ser Ile Val Gln Leu 145 150 155 160 Ala Leu Met Leu Pro Leu Pro Phe Cys Gly Pro Asn Ile Leu Asp Asn 165 170 175 Phe Tyr Cys Asp Val Pro Gln Leu Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 Ser Leu Leu Glu Phe Leu Met Ile Ser Asn Ser Gly Met Leu Val Leu 195 200 205 Ile Trp Phe Leu Leu Leu Leu Ile Ser Tyr Thr Val Ile Leu Val Met 210 215 220 Leu Arg Ser His Ser Gly Gln Ala Lys Lys Lys Ala Ala Ser Thr Cys 225 230 235 240 Thr Thr His Ile Ile Val Val Ser Met Ile Phe Ile Pro Cys Ile Tyr 245 250 255 Ile Tyr Ser Arg Pro Phe Thr Pro Phe Pro Met Asp Lys Ala Val Ser 260 265 270

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Ile Ser Tyr Thr Val Met Thr Pro Met Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Gln Ala Ala Met Lys Arg Leu Gly Lys Arg 290 295 300 Leu Met Val Cys Asn Arg Glu Trp Thr 305 310

<210> 2037 <211> 945 <212> DNA <213> Canis familiaris <400> 2037

atggagccag agaacctcac gtgggtatca gaatttgtct tcttggggtt ctcccagact 60 cgagagctcc agcttttcct gtttctggtg ttcttgtttg tctacaccac cactgtcgtg 120 ggaaacctcc tcatcatggt cacggtgacc tcagacaccc ggctccacac acccatgtac 180 tttctgctcc gaaatctggc tgtgctggac ctctgtttct cctctgtcac tgccccaaag 240 atgctggtgg actttctctc tgagaagaag accatctcct accagggctg catggcccag 300 atcttcttct ttcactttct gggaggtgcc atggtcttct tcctctctgt gatggcctat 360 gaccgcctcg ttgccatctc ccggcccctc cactatgtca ccatcatgaa cactcagctc 420 tgtgtccagc tggtagtgac agcctggatg gtaggttttg tgcattccat tgcccaactg 480 gctctgatgc tcccgctgcc tttctgtggc cccaacatcc tggataactt ctactgcgat 540 gtcccacaag tgctgagact tgcctgcact gacacgtccc ttctggagtt cctcatgatc 600 tccaacagtg ggctgttgga tatcatctgg ttctttctcc tcctgacctc ctactctgtc 660 atcctggtga tgctgaggtc ccactctggg caggcgagga ggaaggcagc ttccacctgt 720 accacccaca ttgtcgttgt gtctatggtt ttcattccaa gcatttacct ctatgctcgg 780 cccttcaccc ccttctccat ggacaaggct gtgtccatca gccacacggt catgaccccc 840 atgctcaacc ccatgatcta cacgctgagg aaccaggagg tgcaggcagc cgtgaggaga 900 ctagggaggc gccggctgct ttgtaaaagg gatcttggac aatga 945

Page 2283

069269_0225_SL.TXT <210> 2038 <211> 314 <212> PRT <213> Canis familiaris

<400> 2038 Leu 15 Gly Met 1 Glu Pro Glu Asn Leu Thr Trp 5 Val Ser 10 Glu Phe Val Phe Phe Ser Gln Thr Arg Glu Leu Gln Leu Phe Leu Phe Leu Val Phe Leu 20 25 30 Phe Val Tyr Thr Thr Thr Val Val Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Thr Ser Asp Thr Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ala Val Leu Asp Leu Cys Phe Ser Ser Val Thr Ala Pro Lys 65 70 75 80 Met Leu Val Asp Phe Leu Ser Glu Lys Lys Thr Ile Ser Tyr Gln Gly 85 90 95 Cys Met Ala Gln Ile Phe Phe Phe His Phe Leu Gly Gly Ala Met Val 100 105 110 Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Leu Val Ala Ile Ser Arg 115 120 125 Pro Leu His Tyr Val Thr Ile Met Asn Thr Gln Leu Cys Val Gln Leu 130 135 140 Val Val Thr Ala Trp Met Val Gly Phe Val His Ser Ile Ala Gln Leu 145 150 155 160 Ala Leu Met Leu Pro Leu Pro Phe Cys Gly Pro Asn Ile Leu Asp Asn 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190

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Ser Leu Leu Glu Phe Leu Met Ile Ser Asn Ser Gly Leu Leu Asp Ile 195 200 205 Ile Trp Phe Phe Leu Leu Leu Thr Ser Tyr Ser Val Ile Leu Val Met 210 215 220 Leu Arg Ser His Ser Gly Gln Ala Arg Arg Lys Ala Ala Ser Thr Cys 225 230 235 240 Thr Thr His Ile Val Val Val Ser Met Val Phe Ile Pro Ser Ile Tyr 245 250 255 Leu Tyr Ala Arg Pro Phe Thr Pro Phe Ser Met Asp Lys Ala Val Ser 260 265 270 Ile Ser His Thr Val Met Thr Pro Met Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Gln Ala Ala Val Arg Arg Leu Gly Arg Arg 290 295 300 Arg Leu Leu Cys Lys Arg Asp Leu Gly Gln

305 310 <210> 2039 <211> 945 <212> DNA <213> Canis familiaris <400> 2039

atggagccag agaacctcac gtgggtatca gaatttgtct tcttgggact ctcccagact 60 cgagagctcc agcttttcct gtttctggtg ttcttgtttg tctacaccac cactgtcgtg 120 ggaaacctcc tcatcatggt cacggtgacc tcagacaccc gactccacac acccatgtac 180 tttctgctcc gaaatctggc tgtgctggac ctctgtttct cctctgtcac tgccccaaag 240 atgctggtgg acttcctctc tgagaagaag accatctcct accagggctg catggcccag 300 atcttcttct ttcactttct gggaggtgcc atggtcttct tcctctctgt gatggcctat 360

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gaccgcctcg ttgccatctc ccggcccctc cactatgtca ccatcatgaa cactcagctc 420 tgtgtccgac tggtggttgc tgcttgggta gggggatttg tgcattccat ttcccaactg 480 gctctgatgc tcccgctgcc tttctgtggc cccaacatcc tggataactt ctactgcgat 540 gtcccacaag tgctgagact tgcctgcact gacacgtccc ttctggagtt cctcatgatc 600 tccaacagtg ggctgttgga tatcatctgg ttctttctcc tcctgatctc ctactctgtc 660 atcctggtga tgctgaggtc ccactctggg caggcgagga ggaaggcagc ttccacctgt 720 accacccaca tcgtcgttgt gtctatggtt ttcattccaa gcatttacct ctatgctcgg 780 cccttcaccc ccttctccat ggacaaggct gtgtccatca gccacacggt catgaccccc 840 atgctcaacc ccatgatcta cacgctgagg aaccaggagg tgcaggcagc cgtgaggaga 900 ctagggaggc gccggctgct ttgtaaaagg gatcttggac aatga 945 <210> 2040 <211> 314 <212> PRT <213> Canis familiaris <400> 2040 Met Glu Pro Glu Asn Leu Thr Trp Val Ser Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Ser Gln Thr Arg Glu Leu Gln Leu Phe Leu Phe Leu Val Phe Leu 20 25 30 Phe Val Tyr Thr Thr Thr Val Val Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Thr Ser Asp Thr Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ala Val Leu Asp Leu Cys Phe Ser Ser Val Thr Ala Pro Lys 65 70 75 80 Met Leu Val Asp Phe Leu Ser Glu Lys Lys Thr Ile Ser Tyr Gln Gly 85 90 95 Cys Met Ala Gln Ile Phe Phe Phe His Phe Leu Gly Gly Ala Met Val

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100

069269_0225_SL.TXT 105 110

Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Leu Val Ala Ile Ser Arg 115 120 125 Pro Leu His Tyr Val Thr Ile Met Asn Thr Gln Leu Cys Val Arg Leu 130 135 140 Val Val Ala Ala Trp Val Gly Gly Phe Val His Ser Ile Ser Gln Leu 145 150 155 160 Ala Leu Met Leu Pro Leu Pro Phe Cys Gly Pro Asn Ile Leu Asp Asn 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 Ser Leu Leu Glu Phe Leu Met Ile Ser Asn Ser Gly Leu Leu Asp Ile 195 200 205 Ile Trp Phe Phe Leu Leu Leu Ile Ser Tyr Ser Val Ile Leu Val Met 210 215 220 Leu Arg Ser His Ser Gly Gln Ala Arg Arg Lys Ala Ala Ser Thr Cys 225 230 235 240 Thr Thr His Ile Val Val Val Ser Met Val Phe Ile Pro Ser Ile Tyr 245 250 255 Leu Tyr Ala Arg Pro Phe Thr Pro Phe Ser Met Asp Lys Ala Val Ser 260 265 270 Ile Ser His Thr Val Met Thr Pro Met Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Gln Ala Ala Val Arg Arg Leu Gly Arg Arg 290 295 300

Arg Leu Leu Cys Lys Arg Asp Leu Gly Gln

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069269_0225_SL.TXT <210> 2041 <211> 948 <212> DNA <213> Canis familiaris <400> 2041

305

310

atggacccag aatccagaac caatggaaca actgttactg agttcatcct gctgggcttg 60 gtggagacac cagggctaca accagttgtc tttgtagtct tcctctttgc ctacctggtc 120 acagtcggag gcaacctcag catcctggct gccatcttgg tggaacccaa actccacaca 180 cccatgtact tcttcctggg gaacctgtca gtgctagatg ttgggtgcat cactgtcact 240 gttccctcaa tgttggctcg cctcttgtcc cacaaacgta cagttcccta cagagcctgc 300 ctcacacaaa ttttcttctt ccatctcttg gctggtgtgg actgcttcct gttgacagcc 360 atggcctatg accgattcct ggccatctgc cggcccctca cctacagcac ccggatgagt 420 cagacagtcc agaaaatatt ggtagctgtg tcctgggctt tagccttcac caatgcactg 480 acccacacag tagccatagc cacactcaac ttttgtggtc ctaatgtgat caaccacttc 540 tactgcgacc tcccacagct cttccagctc tcctgctcca gcactcagct caatgagctg 600 ctgctctttg ctgtgggttt cataatggca ggtaccccct tggctctcat catcacttcc 660 tatgcacatg tggcagctgc agtcctacga atccgctctg ctgagggcag gaagaaagct 720 ttctccacat gtggctccca cctcacagtg gttggcatat tctatgggac aggtgtcttc 780 agctacatga ggctgggctc agtggaggcc tcagacaagg acaaagggat tggtatcctc 840 aacactgtca tcagccccat gctgaaccca ctcatctata gcctccggaa cccggatgtg 900 cagggggctc tgtggcaggt gctcacaggg aagcgagccc ttgcatga 948

<210> 2042 <211> 315 <212> PRT <213> Canis familiaris <400> 2042

Met Asp Pro Glu Ser Arg Thr Asn Gly Thr Thr Val Thr Glu Phe Ile 1 5 10 15

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Leu Leu Gly Leu 20 Val Glu Thr Pro Gly Leu Gln Pro Val Val Phe Val 25 30 Val Phe Leu Phe Ala Tyr Leu Val Thr Val Gly Gly Asn Leu Ser Ile 35 40 45 Leu Ala Ala Ile Leu Val Glu Pro Lys Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Val Leu Asp Val Gly Cys Ile Thr Val Thr 65 70 75 80 Val Pro Ser Met Leu Ala Arg Leu Leu Ser His Lys Arg Thr Val Pro 85 90 95 Tyr Arg Ala Cys Leu Thr Gln Ile Phe Phe Phe His Leu Leu Ala Gly 100 105 110 Val Asp Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Phe Leu Ala 115 120 125 Ile Cys Arg Pro Leu Thr Tyr Ser Thr Arg Met Ser Gln Thr Val Gln 130 135 140 Lys Ile Leu Val Ala Val Ser Trp Ala Leu Ala Phe Thr Asn Ala Leu 145 150 155 160 Thr His Thr Val Ala Ile Ala Thr Leu Asn Phe Cys Gly Pro Asn Val 165 170 175 Ile Asn His Phe Tyr Cys Asp Leu Pro Gln Leu Phe Gln Leu Ser Cys 180 185 190 Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe Ala Val Gly Phe Ile 195 200 205 Met Ala Gly Thr Pro Leu Ala Leu Ile Ile Thr Ser Tyr Ala His Val 210 215 220

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Ala 225 Ala Ala Val Leu Arg Ile 230 Arg Ser Ala Glu Gly Arg Lys Lys Ala 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Gly Ile Phe Tyr Gly 245 250 255 Thr Gly Val Phe Ser Tyr Met Arg Leu Gly Ser Val Glu Ala Ser Asp 260 265 270 Lys Asp Lys Gly Ile Gly Ile Leu Asn Thr Val Ile Ser Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Pro Asp Val Gln Gly Ala Leu 290 295 300 Trp Gln Val Leu Thr Gly Lys Arg Ala Leu Ala 305 310 315

<210> 2043 <211> 948 <212> DNA <213> Canis familiaris <400> 2043

atggagccaa gtgcctgggg gaacaggaca actgtcactg agttcatcct tcttggcctg 60 acagaaaaca taagactgca acccatcctt tttgttgtct tccttgttgc ctatttaatc 120 actgttggag gcaacctcag catcctggct gccatctttg tggagcccaa actccacaca 180 cccatgtact acttcctggg gaatctgtct ctgctggaca ttggatgcat cactgtcacc 240 gtccctccaa tgctagcatg tctcctggcc caccagtgta gagttcccta tgctgcctgc 300 atttcacagc tcttcttttt ccacctcctg gctggtgttg actgtcacct cctgacagcc 360 atggcctatg accgctacct ggccatctgt cagcccctca cctacagcac ccgcatgagc 420 cgtgaagtcc agggtgcctt ggtgggcatt tgctgcacca tttcctttat caatgctttg 480 actcatacag tggctatatc tgtgcttgac ttctgtggcc ctaatgtgat caaccacttc 540 tactgcgacc tcccacccct attccagctc tcctgctcca gcatccacct caatgggaag 600 ctgctttttg tgggagccac tttcatggga gtgttcccca tgatcctcat ctcagtgtct 660

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069269_0225_SL.TXT tatgctcacg ttacagctgc agtgctacga atccgctcag cagaggggag gaagaaggcc 720 ttctctacat gtgggtctca cctcaccgtg gtttgtatct tttatggaac tggcttcttc 780 agttatatgc gtctgggctc agcgtcagtt tcagataagg acaaggggat tgggatcctc 840 aatactatcc ttagccccat gctgaatcca gtcatctata gcctccggaa ccctgatgtg 900 cagggggccc tgaaaagagt gctgatgggg aagcagcccc ctgagtga 948 <210> 2044 <211> 315 <212> PRT <213> Canis familiaris <400> 2044

Met Glu Pro Ser Ala Trp Gly Asn Arg Thr Thr Val Thr Glu Phe Ile 1 5 10 15

Leu Leu Gly Leu Thr Glu Asn Ile Arg Leu Gln Pro Ile Leu Phe Val 20 25 30

Val Phe Leu Val Ala Tyr Leu Ile Thr Val Gly Gly Asn Leu Ser Ile 35 40 45

Leu Ala Ala Ile Phe Val Glu Pro Lys Leu His Thr Pro Met Tyr Tyr 50 55 60

Phe Leu Gly Asn Leu Ser Leu Leu Asp Ile Gly Cys Ile Thr Val Thr 65 70 75 80

Val Pro Pro Met Leu Ala Cys Leu Leu Ala His Gln Cys Arg Val Pro 85 90 95

Tyr Ala Ala Cys Ile Ser Gln Leu Phe Phe Phe His Leu Leu Ala Gly 100 105 110

Val Asp Cys His Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala 115 120 125

Ile Cys Gln Pro Leu Thr Tyr Ser Thr Arg Met Ser Arg Glu Val Gln 130 135 140

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Gly Ala Leu Val Gly Ile Cys Cys Thr Ile Ser Phe Ile Asn Ala Leu 145 150 155 160 Thr His Thr Val Ala Ile Ser Val Leu Asp Phe Cys Gly Pro Asn Val 165 170 175 Ile Asn His Phe Tyr Cys Asp Leu Pro Pro Leu Phe Gln Leu Ser Cys 180 185 190 Ser Ser Ile His Leu Asn Gly Lys Leu Leu Phe Val Gly Ala Thr Phe 195 200 205 Met Gly Val Phe Pro Met Ile Leu Ile Ser Val Ser Tyr Ala His Val 210 215 220 Thr Ala Ala Val Leu Arg Ile Arg Ser Ala Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Cys Ile Phe Tyr Gly 245 250 255 Thr Gly Phe Phe Ser Tyr Met Arg Leu Gly Ser Ala Ser Val Ser Asp 260 265 270 Lys Asp Lys Gly Ile Gly Ile Leu Asn Thr Ile Leu Ser Pro Met Leu 275 280 285 Asn Pro Val Ile Tyr Ser Leu Arg Asn Pro Asp Val Gln Gly Ala Leu 290 295 300 Lys Arg Val Leu Met Gly Lys Gln Pro Pro Glu 305 310 315 <210> 2045 <211> 387 <212> DNA <213> Canis familiaris <400> 2045 atgacaggag ggaaccagac caacatcttt gatttcctcc tctggggact ctcagagtgg 60

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ccagaacagc aacacatcct cttcctgctg ttcctgcaaa tatacatggt cactgtggct 120 ggaaacctgc tcatttttct ggccattgac actgatgcac atctccacat gcccatgtac 180 tacttcttca ccagctgtgc agacatcctt ttcacctccg ctactgtgcc caaggccctg 240 gtgaatatcc agactcagaa caggttcatt tcctacacag gcttcctggt tcagctctac 300 ttcttgactg caagaaacat agacattttt ctcctggcca cagtggccta tgaattctac 360 atggccatct accaccctct ccactac 387

<210> 2046 <211> 129 <212> PRT <213> Canis familiaris <400> 2046

Met Thr Gly Gly Asn Gln Thr Asn Ile Phe Asp Phe Leu Leu Trp Gly 1 5 10 15 Leu Ser Glu Trp Pro Glu Gln Gln His Ile Leu Phe Leu Leu Phe Leu 20 25 30 Gln Ile Tyr Met Val Thr Val Ala Gly Asn Leu Leu Ile Phe Leu Ala 35 40 45 Ile Asp Thr Asp Ala His Leu His Met Pro Met Tyr Tyr Phe Phe Thr 50 55 60 Ser Cys Ala Asp Ile Leu Phe Thr Ser Ala Thr Val Pro Lys Ala Leu 65 70 75 80 Val Asn Ile Gln Thr Gln Asn Arg Phe Ile Ser Tyr Thr Gly Phe Leu 85 90 95 Val Gln Leu Tyr Phe Leu Thr Ala Arg Asn Ile Asp Ile Phe Leu Leu 100 105 110 Ala Thr Val Ala Tyr Glu Phe Tyr Met Ala Ile Tyr His Pro Leu His 115 120 125

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Tyr <210> 2047 <211> 945 <212> DNA <213> Canis familiaris <400> 2047 atggccccgg gcaatgccac ggcagccgcc gagttcctcc tcctgggcct gctggatgga 60 gccgacgtcc acccgctgct cttcctgctt ttcctcggtg tctacttgct caacgcgctg 120 ggcaacctga ccatggtggt ggtggtgagg tgggatgagg ccctccgctg ccccatgtac 180 tacttcttgg gccacctaag cctcgtggac gtgtgcttcg ctagcgtcac gctccccagg 240 ctgctggccg gcctgctcca cccgggccag gccgtgtcct tccagggatg ctttgcccag 300 atgtacttct tcgtggccct gggcatcacg gagagctacc tgctggcagc catggcctac 360 gaccgcgcgg tggccgtctg ccggccgctg cactaccggg cggtgctgac gccggggcgc 420 tgcgccgcgc tggtggccgc gtcctgggcg gtggcccacc tgcactcgct gctgcacacg 480 ctgctcatct ccgcgctctc ctacccgcgc cccgccgccg tgcgccactt cttctgcgac 540 atgacggtga tgctgagctt ggcgacctcg gacacggcgg ccgcggagac tgccgtcttc 600 tccgagggcc tggccgtggt gctcaccccg ctgctcctcg tgtcgctctc ctacgcgcgc 660 atcctcggcg cggtgctggg actgcggtcg gccgggggcc ggcgccgcgc cttctccacc 720 tgcggggccc acctggtggt ggtgtcgctc ttcttcggct ctgtcctttc cgtctacttc 780 cggccctcgt ccgcctactc agcgcgctac gaccgcctgg ccagcgtggt ctatgcggtg 840 ctcacaccca ccttgaaccc tttcatctac agccttcgca acagggaggt caagggcgcc 900 ctgaaaaggg gactcgggtg gagggctgcg tcccaagact tgtga 945 <210> 2048 <211> 314 <212> PRT <213> Canis familiaris <400> 2048

Met Ala Pro Gly Asn Ala Thr Ala Ala Ala Glu Phe Leu Leu Leu Gly 1 5 10 15

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Leu Leu Asp Gly 20 Ala Asp Val His Pro Leu Leu Phe Leu Leu Phe Leu 25 30 Gly Val Tyr Leu Leu Asn Ala Leu Gly Asn Leu Thr Met Val Val Val 35 40 45 Val Arg Trp Asp Glu Ala Leu Arg Cys Pro Met Tyr Tyr Phe Leu Gly 50 55 60 His Leu Ser Leu Val Asp Val Cys Phe Ala Ser Val Thr Leu Pro Arg 65 70 75 80 Leu Leu Ala Gly Leu Leu His Pro Gly Gln Ala Val Ser Phe Gln Gly 85 90 95 Cys Phe Ala Gln Met Tyr Phe Phe Val Ala Leu Gly Ile Thr Glu Ser 100 105 110 Tyr Leu Leu Ala Ala Met Ala Tyr Asp Arg Ala Val Ala Val Cys Arg 115 120 125 Pro Leu His Tyr Arg Ala Val Leu Thr Pro Gly Arg Cys Ala Ala Leu 130 135 140 Val Ala Ala Ser Trp Ala Val Ala His Leu His Ser Leu Leu His Thr 145 150 155 160 Leu Leu Ile Ser Ala Leu Ser Tyr Pro Arg Pro Ala Ala Val Arg His 165 170 175 Phe Phe Cys Asp Met Thr Val Met Leu Ser Leu Ala Thr Ser Asp Thr 180 185 190 Ala Ala Ala Glu Thr Ala Val Phe Ser Glu Gly Leu Ala Val Val Leu 195 200 205 Thr Pro Leu Leu Leu Val Ser Leu Ser Tyr Ala Arg Ile Leu Gly Ala 210 215 220

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Val 225 Leu Gly Leu Arg Ser Ala Gly Gly Arg Arg Arg Ala Phe Ser Thr 230 235 240 Cys Gly Ala His Leu Val Val Val Ser Leu Phe Phe Gly Ser Val Leu 245 250 255 Ser Val Tyr Phe Arg Pro Ser Ser Ala Tyr Ser Ala Arg Tyr Asp Arg 260 265 270 Leu Ala Ser Val Val Tyr Ala Val Leu Thr Pro Thr Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Glu Val Lys Gly Ala Leu Lys Arg Gly 290 295 300 Leu Gly Trp Arg Ala Ala Ser Gln Asp Leu 305 310

<210> 2049 <211> 948 <212> DNA <213> Canis familiaris <400> 2049

atgaaaatgg gcaaccgaac tgtcatctca gaattcatcc tgctgggcct gcccattgat 60 ccagatcagc gagacctgtt ctacgccctg ttcctggcca tgtatgttac caccatcctg 120 gggaacctac tcatcattgt cctcattcac ctggactcgc acctccacac acccatgtat 180 ttgtttctca gcaatttatc cttctctgac ctctgcttct cttctgtcac aatgcccaag 240 ttgctgcaga acatgcagag ccaagtcccg tccatcccct atgctggctg cctgacccaa 300 atgtacttct tcctgttttt tgcagacctg gagagcttcc tcctggtggc catggcctat 360 gaccgctatg tggccatctg cttccccctg cactacacca ccatcatgag ccccaagctc 420 tgtttctcct tgttgatgct gtcctgggtg ctgaccactt ttatctctct tttgcacacc 480 ctactcatgg ctcggctatc tttctgtgct gataatgtga tccctcactt tttctgtgac 540 atgtcagctc tgctaaagtt ggcctgctct gacattctga taaatgaaat ggtgatattt 600 gtcttgggag ggctcatcat ttttgttccg tttctgttga tctctttatc ctatgcatgg 660

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069269_0225_SL.TXT attgtgtcct ccatcctcaa agtcccttct gctaggggca tctgcaaggc cttctccacc tgtggctccc acctctcagt ggtgtctctc ttctatggga caatcattgg tctctacttg tgcccctcag ctaataattc taccgttaag gagactatca tggctgttat gtacactgtg attaccccca tgctgaatcc ctttatttac agcctgagga atcaggacat aaaaggagcc ttgggaagag tcttttcaaa gtggacaatt cagctttctt tgggatag

720

780

840

900

948 <210> 2050 <211> 315 <212> PRT <213> Canis familiaris <400> 2050

Met Lys Met Gly Asn Arg Thr Val 1 5

Leu Pro Ile Asp Pro Asp Gln Arg 20

Ala Met Tyr Val Thr Thr Ile Leu 35 40

Ile His Leu Asp Ser His Leu His 50 55

Asn Leu Ser Phe Ser Asp Leu Cys 65 70

Leu Leu Gln Asn Met Gln Ser Gln 85

Cys Leu Thr Gln Met Tyr Phe Phe 100

Phe Leu Leu Val Ala Met Ala Tyr 115 120

Pro Leu His Tyr Thr Thr Ile Met 130 135

Ile Ser 10 Glu Phe Ile Leu Leu 15 Gly Asp 25 Leu Phe Tyr Ala Leu 30 Phe Leu Gly Asn Leu Leu Ile 45 Ile Val Leu Thr Pro Met Tyr 60 Leu Phe Leu Ser Phe Ser Ser 75 Val Thr Met Pro Lys 80 Val Pro 90 Ser Ile Pro Tyr Ala 95 Gly Leu 105 Phe Phe Ala Asp Leu 110 Glu Ser Asp Arg Tyr Val Ala 125 Ile Cys Phe Ser Pro Lys Leu 140 Cys Phe Ser Leu

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Leu 145 Met Leu Ser Trp Val Leu Thr Thr Phe Ile Ser Leu Leu His Thr 160 150 155 Leu Leu Met Ala Arg Leu Ser Phe Cys Ala Asp Asn Val Ile Pro His 165 170 175 Phe Phe Cys Asp Met Ser Ala Leu Leu Lys Leu Ala Cys Ser Asp Ile 180 185 190 Leu Ile Asn Glu Met Val Ile Phe Val Leu Gly Gly Leu Ile Ile Phe 195 200 205 Val Pro Phe Leu Leu Ile Ser Leu Ser Tyr Ala Trp Ile Val Ser Ser 210 215 220 Ile Leu Lys Val Pro Ser Ala Arg Gly Ile Cys Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Gly Leu Tyr Leu Cys Pro Ser Ala Asn Asn Ser Thr Val Lys Glu Thr 260 265 270 Ile Met Ala Val Met Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Asp Ile Lys Gly Ala Leu Gly Arg Val 290 295 300 Phe Ser Lys Trp Thr Ile Gln Leu Ser Leu Gly 305 310 315

<210> 2051 <211> 942 <212> DNA <213> Canis familiaris <400> 2051

Page 2298

069269_0225_SL.TXT atgacagaaa agaatcaaac tgtcgtctca gaatttgtcc tccttggcct gcccattgat 60 ccagatcagc gagacctgtt ctacgccctg ttcctggcca tgtatgttac cacaatcctg 120 gggaacctac tcatcattgt cctcattcag ctggactcgc acctccacac acccatgtat 180 ttgtttctca gcaatttatc cttctctgac ctctgcttct cttctgtcac aatgcccaag 240 ttgctgcaga acatgcagag ccaagtcccg tccatcccct atgctggctg cctgacccaa 300 atgtacttct tcctgttttt tggagatctg gagagcttcc tcctggtggc catggcctat 360 gaccgctatg tggccatctg cttcccccta cactacacca ccatcatgag ccccaagctc 420 tgtttctccc tgttggtgct gtcatgggtg ctgaccatgt tccatgctgt attacacact 480 ctgttaatgg ccagattgtg tttttgtgcc aacacaatcc cccacttttt ttgtgatatg 540 tctgctctgc tgaagctggc ctgctctgac actcaagtta atgagttggt gatatttatc 600 atgggagggc tcattctcgt gatcccattc ctgctcatca tcacgtctta tgcacggatt 660 gtgtcctcca tcctcaaggt tccttctgcc ataggcatct gcaaggtctt ctccacctgt 720 ggctcccacc tctcagtggt gtctctcttc tatgggacag ttattggtct ctatttatgc 780 ccatcagcta ataattctac tgttaaggag actatcatgg ctatgatgta cactgtggtc 840 acccccatgc tgaacccctt catctacagc ctgaggaata aagacatgaa gggagccctg 900 agaagagtca tttgtagaaa gaaaattacc ttctctgtgt ga 942 <210> 2052 <211> 313 <212> PRT <213> Canis familiaris

<400> 2052 Met 1 Thr Glu Lys Asn Gln Thr Val Val Ser Glu Phe Val Leu Leu Gly 5 10 15 Leu Pro Ile Asp Pro Asp Gln Arg Asp Leu Phe Tyr Ala Leu Phe Leu 20 25 30 Ala Met Tyr Val Thr Thr Ile Leu Gly Asn Leu Leu Ile Ile Val Leu 35 40 45 Ile Gln Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser Page 2299

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50 55 60 Asn Leu Ser Phe Ser Asp Leu Cys Phe Ser Ser Val Thr Met Pro Lys 65 70 75 80 Leu Leu Gln Asn Met Gln Ser Gln Val Pro Ser Ile Pro Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Met Tyr Phe Phe Leu Phe Phe Gly Asp Leu Glu Ser 100 105 110 Phe Leu Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe 115 120 125 Pro Leu His Tyr Thr Thr Ile Met Ser Pro Lys Leu Cys Phe Ser Leu 130 135 140 Leu Val Leu Ser Trp Val Leu Thr Met Phe His Ala Val Leu His Thr 145 150 155 160 Leu Leu Met Ala Arg Leu Cys Phe Cys Ala Asn Thr Ile Pro His Phe 165 170 175 Phe Cys Asp Met Ser Ala Leu Leu Lys Leu Ala Cys Ser Asp Thr Gln 180 185 190 Val Asn Glu Leu Val Ile Phe Ile Met Gly Gly Leu Ile Leu Val Ile 195 200 205 Pro Phe Leu Leu Ile Ile Thr Ser Tyr Ala Arg Ile Val Ser Ser Ile 210 215 220 Leu Lys Val Pro Ser Ala Ile Gly Ile Cys Lys Val Phe Ser Thr Cys 225 230 235 240 Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Val Ile Gly 245 250 255 Leu Tyr Leu Cys Pro Ser Ala Asn Asn Ser Thr Val Lys Glu Thr Ile

Page 2300

260

069269_0225_SL.TXT 265 270

Met Ala Met Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Arg Val Ile 290 295 300 Cys Arg Lys Lys Ile Thr Phe Ser Val

305 310 <210> 2053 <211> 909 <212> DNA <213> Canis familiaris <400> 2053 atgcatggaa gcaaccagag tgaggccacg gagttcccac tcctggggat ctcagagagt 60 cctaaagagc agcagatctt gttctggatg ctcttgtcca tgtacctggt cacagtggtg 120 ggaaatgtgc tcatcattct ggccattggc tctaactctc acctacacac tcccatgtat 180 ttattcttag ccaacctctc cttcacagac ctcttctttg tcaccaatat aaaacccaag 240 acattagtga gcctccagtc tcagaacaaa gccatctcct atgcaggatg tctgacacag 300 ctctacttcc tggtctcctt ggtgaccctg gacaacttca tcttggccac aatggcatat 360 gaccgctatg tagccatctg ccgccccctc cactacacca cagccatgag ccctggactc 420 tgtattttgc tcctcgcctt gtgctgggca ctttctgccc tctgtggcct tttcctcacg 480 ctcttcatga ccaaggtgac attctgtgga tcccggaaga tccactacat cttctgtgag 540 atgtatatcc tgctgaggct tgcatgttcc aacacccaga tcattcacac agtgcagatt 600 accacaggct gcttcatctt cttcacccca ctagggttca tgataatgtc ctatgtctgg 660 attgtcagag ccatcctcca aatactctca gcctctagca agtacaaagc tttctccacc 720 tgtgcctccc atttggctgt agtctccctc ttctatggga cactttgtat ggtatatctg 780 cagcctctcc aaacctactc catgaaggac tcagtagcta cagtgatgca tgctgtggtg 840 accctcatga tgaacccttt catctacagc ctgaggaaca aggacatgca tggggctctg 900 ggaagactg 909

Page 2301

069269_0225_SL.TXT <210> 2054 <211> 303 <212> PRT <213> Canis familiaris

<400> 2054 Met 1 His Gly Ser Asn 5 Gln Ser Glu Ala Thr 10 Glu Phe Pro Leu Leu 15 Gly Ile Ser Glu Ser Pro Lys Glu Gln Gln Ile Leu Phe Trp Met Leu Leu 20 25 30 Ser Met Tyr Leu Val Thr Val Val Gly Asn Val Leu Ile Ile Leu Ala 35 40 45 Ile Gly Ser Asn Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ala 50 55 60 Asn Leu Ser Phe Thr Asp Leu Phe Phe Val Thr Asn Ile Lys Pro Lys 65 70 75 80 Thr Leu Val Ser Leu Gln Ser Gln Asn Lys Ala Ile Ser Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Leu Tyr Phe Leu Val Ser Leu Val Thr Leu Asp Asn 100 105 110 Phe Ile Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Thr Thr Ala Met Ser Pro Gly Leu Cys Ile Leu Leu 130 135 140 Leu Ala Leu Cys Trp Ala Leu Ser Ala Leu Cys Gly Leu Phe Leu Thr 145 150 155 160 Leu Phe Met Thr Lys Val Thr Phe Cys Gly Ser Arg Lys Ile His Tyr 165 170 175

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Ile Phe Cys Glu Met Tyr Ile Leu Leu Arg Leu Ala Cys Ser Asn Thr 180 185 190 Gln Ile Ile His Thr Val Gln Ile Thr Thr Gly Cys Phe Ile Phe Phe 195 200 205 Thr Pro Leu Gly Phe Met Ile Met Ser Tyr Val Trp Ile Val Arg Ala 210 215 220 Ile Leu Gln Ile Leu Ser Ala Ser Ser Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Leu Cys 245 250 255 Met Val Tyr Leu Gln Pro Leu Gln Thr Tyr Ser Met Lys Asp Ser Val 260 265 270 Ala Thr Val Met His Ala Val Val Thr Leu Met Met Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met His Gly Ala Leu Gly Arg Leu 290 295 300

<210> 2055 <211> 912 <212> DNA <213> Canis familiaris <400> 2055

atggatgaaa gcaaccaaac tatagtctct gagttcctgc tcctggggct ctctgagagt 60 cctgagcagc agcgggtcca gttctggatg ttcctgtcca tgtacctggt cacagtggta 120 ggaaatgtgc tcatcatcct ggccatcagc tttgatcccc gcctgcacac tcccatgtac 180 ttcttcctgg ccaacctctc cttcactgac ctcttcttcg tcaccaatac aacaataccc 240 aagatgctgg tgagcctcca gtctcagaac aaagccatct cctatgcagg gtgtctgaca 300 cagctttact tcctggtctc cttggtggcc ctggacaacc tcatcctggc cacaatggca 360 tatgaccgct atgtggccat ctgccgcccc ctccactaca ccacagccat gagccctgga 420

Page 2303

069269_0225_SL.TXT

ctctgtattt tgctcctcgc cttgtgttgg gcactttctg ccctctatgg cctcacccac 480 accctcctaa tgaccagagt gacattctgt ggatcccgga agatccacta catcttctgt 540 gagatgtatg tcctgctgag gcttgcatgc tccaacaccc aagtaaatca tacagtgctg 600 attgctacag gatctttcat cttcctcgcc ccactagggt tcacgataat gtcctatgtc 660 tggattgtca gagccatcct ccgaataccc tcagcctcta gcaagtacaa agccttctcc 720 acctgtgcct cccatttggc tgtagtctcc ctcttctatg ggacactttg tatggtatat 780 ctgcagcctc tccacaccta ctccatgaag gactcagtag ccacagtgat gtatgctgtg 840 gtgaccccca tgatgaaccc tttcatctac agcctgagaa acaaggacat gcatggggct 900 ctgggaagac tg 912

<210> 2056 <211> 304 <212> PRT <213> Canis familiaris

<400> 2056 Gln Thr Ile Val Ser Glu Phe Leu Leu Leu Gly Met Asp 1 Glu Ser Asn 5 10 15 Leu Ser Glu Ser Pro Glu Gln Gln Arg Val Gln Phe Trp Met Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Val Val Gly Asn Val Leu Ile Ile Leu Ala 35 40 45 Ile Ser Phe Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Thr Asp Leu Phe Phe Val Thr Asn Thr Thr Ile Pro 65 70 75 80 Lys Met Leu Val Ser Leu Gln Ser Gln Asn Lys Ala Ile Ser Tyr Ala 85 90 95 Gly Cys Leu Thr Gln Leu Tyr Phe Leu Val Ser Leu Val Ala Leu Asp 100 105 110

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Asn Leu Ile Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Arg Pro Leu His Tyr Thr Thr Ala Met Ser Pro Gly Leu Cys Ile Leu 130 135 140 Leu Leu Ala Leu Cys Trp Ala Leu Ser Ala Leu Tyr Gly Leu Thr His 145 150 155 160 Thr Leu Leu Met Thr Arg Val Thr Phe Cys Gly Ser Arg Lys Ile His 165 170 175 Tyr Ile Phe Cys Glu Met Tyr Val Leu Leu Arg Leu Ala Cys Ser Asn 180 185 190 Thr Gln Val Asn His Thr Val Leu Ile Ala Thr Gly Ser Phe Ile Phe 195 200 205 Leu Ala Pro Leu Gly Phe Thr Ile Met Ser Tyr Val Trp Ile Val Arg 210 215 220 Ala Ile Leu Arg Ile Pro Ser Ala Ser Ser Lys Tyr Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Leu 245 250 255 Cys Met Val Tyr Leu Gln Pro Leu His Thr Tyr Ser Met Lys Asp Ser 260 265 270 Val Ala Thr Val Met Tyr Ala Val Val Thr Pro Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met His Gly Ala Leu Gly Arg Leu 290 295 300

<210> 2057 <211> 852 <212> DNA

Page 2305

069269_0225_SL.TXT <213> Canis familiaris <400> 2057

gagcaacaac aggtccagtt ctggatgttc ctgtccaggt ccctggttac aggggtggga 60 aatgtgttca tcatcctggc cattggctct gatccctgcc tgcacactcc tatgtactcc 120 ctcctggcca acttctcctt cacagacctc ttctttgtca ccaatacaat acccaagatg 180 ctggcaaacc ttcagtctca gaacaaagcc atctcctatg cagggtgcct aacacagctc 240 tacttcttgg tctccctggt gacactggac aacctcattc tggccacaat ggcatatgac 300 cactatgtgg ccatctgccg ccccctccac tatgtcacag ccatgagccc tggactctct 360 attttgttcc tcaccttgtg ttgggcactt tctgtcatct gtggccttac ccacaccctc 420 cttctgacca gagtgacctt ctttggttcc tggaagatcc gctacatctt ctgtgagatg 480 tgtgtcatgc taaggttggc ctattccaac acccagagca ttcacatact gctgattacc 540 acaggcatct ttatcttcct gaccccctta gggtttgtga tcatgtccta tgtccacact 600 gtcaaagcca tcctctgaat gccctcagcc tctagcaagt actaagcctt ctccacttgt 660 gccccccccc ccaatttggc tgtagtctcc ctcttctatg ggacacttgg tatggtatat 720 ctgcagcccc tccacaccta ctccatgaag gactcagtag ccacaatgat gtatgctgtg 780 gtgaccccca tgatgaaccc tttcatctac agcctgaaga acaaggacat gcatggggct 840 ctgggaagac tg 852

<210> 2058 <211> 205 <212> PRT <213> Canis familiaris <400> 2058

Glu 1 Gln Gln Gln Val Gln Phe Trp Met Phe Leu Ser Arg Ser Leu Val 5 10 15 Thr Gly Val Gly Asn Val Phe Ile Ile Leu Ala Ile Gly Ser Asp Pro 20 25 30 Cys Leu His Thr Pro Met Tyr Ser Leu Leu Ala Asn Phe Ser Phe Thr 35 40 45

Page 2306

Asp Leu 50 Phe Phe Val Thr Asn 55 069269_0225_SL.TXT Ala Asn Leu Thr Ile Pro Lys Met 60 Leu Gln Ser Gln Asn Lys Ala Ile Ser Tyr Ala Gly Cys Leu Thr Gln Leu 65 70 75 80 Tyr Phe Leu Val Ser Leu Val Thr Leu Asp Asn Leu Ile Leu Ala Thr 85 90 95 Met Ala Tyr Asp His Tyr Val Ala Ile Cys Arg Pro Leu His Tyr Val 100 105 110 Thr Ala Met Ser Pro Gly Leu Ser Ile Leu Phe Leu Thr Leu Cys Trp 115 120 125 Ala Leu Ser Val Ile Cys Gly Leu Thr His Thr Leu Leu Leu Thr Arg 130 135 140 Val Thr Phe Phe Gly Ser Trp Lys Ile Arg Tyr Ile Phe Cys Glu Met 145 150 155 160 Cys Val Met Leu Arg Leu Ala Tyr Ser Asn Thr Gln Ser Ile His Ile 165 170 175 Leu Leu Ile Thr Thr Gly Ile Phe Ile Phe Leu Thr Pro Leu Gly Phe 180 185 190 Val Ile Met Ser Tyr Val His Thr Val Lys Ala Ile Leu 195 200 205

<210> 2059 <211> 930 <212> DNA <213> Canis familiaris <400> 2059 atgagggaag acaaccaatc ctctaccctg gaattcatcc tcctgggagt tactggtcag caggaccagg aagacttttt ctttaccctc ttcctgttca tttaccccat cacgttgatt ggaaacttgc tcatcatctt ggccattcgc tctgatgttc gccttcacaa tcccatgtac

120

180

Page 2307

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tttttccttg ccaacctctc ctttgttgac atcctcttct cttctgtaac catccctaaa 240 atgctggcaa atcatctctt gcacagcaaa gccatctcct ttggtggatg cctaacacag 300 ttgtatttta tgattgcctt gggcaacaca gatagctata tcttggctgc aatggcatat 360 gatcgtgcgg tggccatcag tcgcccactt cattacacaa caatcatgag cccatggact 420 tgtgtcctcc tagttgttgg gtcttgggtg gttggtaatg ccaatgccct cccccacact 480 ctgctcacag ccaggctgtc cttctgtggc aacaaggaag tagccaactt ctactgtgat 540 attacccctt tgcttaagct gtcctgttct gacatcctct ttaatgtgag gatgatgtac 600 ctaggggttg gtgtcttctc tgtgccatta ctatgcatca ttatctccta tgtccaggtc 660 ttttccacag tcttacgggt cccatctacc aaaggtgtgc tcaaggcctt ctctacctgt 720 ggttcccacc tcacagttgt ttttctgtat tatgggacag tcatgggcat gtatttccgc 780 cctctgtcta gttacagcct aaaggatgca atcataactg ttatgtacat ggcagtgacc 840 ccaatgttaa atcctttcat ttatagtttg agaaaccgag acatgaaggc tgccctgggg 900 atactattat gcaagagaat ctccttataa 930

<210> 2060 <211> 309 <212> PRT <213> Canis familiaris <400> 2060

Met Arg Glu Asp Asn Gln Ser Ser Thr Leu Glu Phe Ile Leu Leu Gly 1 5 10 15 Val Thr Gly Gln Gln Asp Gln Glu Asp Phe Phe Phe Thr Leu Phe Leu 20 25 30 Phe Ile Tyr Pro Ile Thr Leu Ile Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Arg Ser Asp Val Arg Leu His Asn Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Leu Phe Ser Ser Val Thr Ile Pro Lys 65 70 75 80

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Met Leu Ala Asn His 85 Leu Leu His Ser Lys Ala Ile Ser Phe Gly Gly 90 95 Cys Leu Thr Gln Leu Tyr Phe Met Ile Ala Leu Gly Asn Thr Asp Ser 100 105 110 Tyr Ile Leu Ala Ala Met Ala Tyr Asp Arg Ala Val Ala Ile Ser Arg 115 120 125 Pro Leu His Tyr Thr Thr Ile Met Ser Pro Trp Thr Cys Val Leu Leu 130 135 140 Val Val Gly Ser Trp Val Val Gly Asn Ala Asn Ala Leu Pro His Thr 145 150 155 160 Leu Leu Thr Ala Arg Leu Ser Phe Cys Gly Asn Lys Glu Val Ala Asn 165 170 175 Phe Tyr Cys Asp Ile Thr Pro Leu Leu Lys Leu Ser Cys Ser Asp Ile 180 185 190 Leu Phe Asn Val Arg Met Met Tyr Leu Gly Val Gly Val Phe Ser Val 195 200 205 Pro Leu Leu Cys Ile Ile Ile Ser Tyr Val Gln Val Phe Ser Thr Val 210 215 220 Leu Arg Val Pro Ser Thr Lys Gly Val Leu Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Ser His Leu Thr Val Val Phe Leu Tyr Tyr Gly Thr Val Met Gly 245 250 255 Met Tyr Phe Arg Pro Leu Ser Ser Tyr Ser Leu Lys Asp Ala Ile Ile 260 265 270 Thr Val Met Tyr Met Ala Val Thr Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285

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069269_0225_SL.TXT

Ser Leu Arg Asn Arg Asp Met Lys Ala Ala Leu Gly Ile Leu Leu Cys 290 295 300

Lys Arg Ile Ser Leu

305 <210> 2061 <211> 897 <212> DNA <213> Canis familiaris <400> 2061 atgggaggag acaatgagtc ctttaccctt ggtttcatcc tcctgggagt tagtagacag 60 taaaaatagt aagacttctt cttcatcctc ttcctcttca tttaccccat cacattgatt 120 ggaaaactgc tcatcatctt ggccattcgt tctgacattc gccttcacaa ccctatgtat 180 tttttccttg ccaatctctc ctttgttgac atcctcttct cttctgtaac catccctaaa 240 atgttagcca accatgtctt agggagcaaa gccatctgct ttgggggatg cctaacacaa 300 atgtgtttca tgttagcctt gggtttcaca gatagttata tccaggcttc aatggcttat 360 gatgatgcgg tggccatcag tcatcctctt cattatataa tgattatgag cctatggact 420 tgtgtcctcc tagttgttgg gtcttaggta gttgaaaatg ccaatgccct cccccacact 480 ctgctcacag ctagtatgcc cttctgtgac aaccagaaag tagccaactt ctactgtgac 540 attgtctctt gactcaagct atcctgttct gacacccact taaatgtgag gatgatatac 600 ctaggggttg gtgttttttc tgtgccatta ctatgtatca tcatctccta agtctgagtc 660 ttttccacag acttgcaggt tccatccagg aagggagtgc tcaaggcctt ctcctgtggt 720 tcccacctca caattgtttc cctgtattat gggacagtta tgagcatgta tttctacctt 780 ctgactagtt atggcctaaa agatgaagtg ataactgtga tgtgcatcac agtgccccca 840 gtgttaaatc ctttcattta tagtctgaga aaccaagaca tgaagtctgc cctgggg 897 <210> 2062 <211> 46 <212> PRT <213> Canis familiaris <400> 2062

Page 2310

Met Ser Met Tyr Phe Tyr Leu 069269_0225_SL.TXT Leu Thr Ser Tyr Gly Leu Lys Asp Glu 1 5 10 15

Val Ile Thr Val Met Cys Ile Thr Val Pro Pro Val Leu Asn Pro Phe 20 25 30

Ile Tyr Ser Leu Arg Asn Gln Asp Met Lys Ser Ala Leu Gly 35 40 45

<210> 2063 <211> 954 <212> DNA <213> Canis familiaris <400> 2063

atggaaagag ggaaccagac cagcagcttt gagttcctcc tctggggact ctcagagcgg 60 ccagagcagc agaatatcct tttcctgctg ttcctgtgga tatatgtgat cactgtggct 120 ggaaacctgc tcattgtcct ggccattggt actgatgcac gcctccacac acctatgtac 180 ttcttccttg ccagcctttc ctgtgcagac atccttttca cctccaccac tgtgcccaag 240 gccttggtta acatccagac ccagagcagg tccatttcct acacgggatg cctggttcag 300 ctctacttct tcttgacttt tggggacatg gacatctttc tcctggccac aatggcctat 360 gaccgctatg tggccatctg ccaccctctc cactacaaga tgatcatgag ccgccggcgc 420 tgcaccctcc tggttactgc ttgctggatc cttacaagtc ttgttgccat gacccacact 480 ttcctcatct ttcgacttaa tttttgctct aagaaaatca ttcctgactt cttctgtgat 540 ctgggacccc tgatgaaggt gtcttgctct gacactcaag tcaatgagct tgtgctcctc 600 ttcttggggg gagcagtcat tttaatcccc ttcattctca tcctggtctc ttatatgcac 660 atcgtttcag ccatcctcag agtcccctcc gcccagggaa ggtacaaggc cttctctacc 720 tgtgggtcac accttgctgt tgttgctctg ttctttggga cagtgatcag ggcttatctg 780 tgtccttcat catcttcctc caactccata gaagaggata cagcagctgc tgtcatgtac 840 acagtggtaa ctcccctgct gaaccccttc atttatagcc tgcggaacaa agacatgaag 900 tgcgccttgg ggagatttct cagaggcaaa gtcttctttt catggggcca gtga 954

<210> 2064

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069269_0225_SL.TXT <211> 317 <212> PRT <213> Canis familiaris

<400> 2064 Trp 15 Gly Met 1 Glu Arg Gly Asn Gln Thr Ser 5 Ser Phe 10 Glu Phe Leu Leu Leu Ser Glu Arg Pro Glu Gln Gln Asn Ile Leu Phe Leu Leu Phe Leu 20 25 30 Trp Ile Tyr Val Ile Thr Val Ala Gly Asn Leu Leu Ile Val Leu Ala 35 40 45 Ile Gly Thr Asp Ala Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Ser Leu Ser Cys Ala Asp Ile Leu Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Ala Leu Val Asn Ile Gln Thr Gln Ser Arg Ser Ile Ser Tyr Thr Gly 85 90 95 Cys Leu Val Gln Leu Tyr Phe Phe Leu Thr Phe Gly Asp Met Asp Ile 100 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Lys Met Ile Met Ser Arg Arg Arg Cys Thr Leu Leu 130 135 140 Val Thr Ala Cys Trp Ile Leu Thr Ser Leu Val Ala Met Thr His Thr 145 150 155 160 Phe Leu Ile Phe Arg Leu Asn Phe Cys Ser Lys Lys Ile Ile Pro Asp 165 170 175 Phe Phe Cys Asp Leu Gly Pro Leu Met Lys Val Ser Cys Ser Asp Thr 180 185 190

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Gln Val Asn Glu Leu Val Leu Leu Phe Leu Gly Gly Ala Val Ile Leu 195 200 205 Ile Pro Phe Ile Leu Ile Leu Val Ser Tyr Met His Ile Val Ser Ala 210 215 220 Ile Leu Arg Val Pro Ser Ala Gln Gly Arg Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ala Val Val Ala Leu Phe Phe Gly Thr Val Ile 245 250 255 Arg Ala Tyr Leu Cys Pro Ser Ser Ser Ser Ser Asn Ser Ile Glu Glu 260 265 270 Asp Thr Ala Ala Ala Val Met Tyr Thr Val Val Thr Pro Leu Leu Asn 275 280 285 Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Cys Ala Leu Gly 290 295 300 Arg Phe Leu Arg Gly Lys Val Phe Phe Ser Trp Gly Gln

305 310 315 <210> 2065 <211> 897 <212> DNA <213> Canis familiaris <400> 2065

aacaatagtg gagtctctga gttcctgctc ctggggattt ctgagagtcc tgagcagcag 60 cgggtccagt tctggatgtt cctgtccatg tacctggtca cagtggtggg aaatgtgctc 120 atcatcctgg ccatcagctt tgatccccgc ctgcacgctc ccatgtactt cttcctggcc 180 aacctttcct tcactgacct cttctttgtc accaatacaa tacccaagat gctggtgagc 240 ctccagtctc agaacaaagc catctcctat gcagggtgtc tgacacagct ttacttcctg 300 gtctccttgg tggccctgga caacctcatc ctggccacaa tggcatatga ccgctatgtg 360 gccatctgcc gccccctcca ctacaccaca gccatgagcc ctggactctg tattttgctc 420

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ctcgccttgt gttgggcact ttctgccctc tatggcctca cccacaccct cctcatgacc 480 agagtgacat tttgtggatc ccggaagatc cactacatct tctgtgagat gtatgttctg 540 ctgaggctcg catgttccaa cactcaagtc aatcacacag tgctgattgc cacaggctgc 600 tttatcttcc tcaccccctt agggttcatg ataatgtcct atgtctgaat tgtcagagcc 660 atcctccgaa taccctcagc cactgggaag tacaaagcct tctccacctg tgcctcccat 720 ttggctgtag tctccctctt ctatgggaca cttggtatgg tatatctgca gcccctccag 780 acctactcca tgaaggactc agtagccaca gtgatgtatg ctgtggtgac ccccatgatg 840 aaccctttca tctacagcct gaggaacaag gacatgcatg gggctctggg aagactg 897

<210> 2066 <211> 215 <212> PRT <213> Canis familiaris

<400> 2066 Ser Glu Phe Leu Leu Leu Gly Ile Ser Glu Ser Asn Asn 1 Ser Gly Val 5 10 15 Pro Glu Gln Gln Arg Val Gln Phe Trp Met Phe Leu Ser Met Tyr Leu 20 25 30 Val Thr Val Val Gly Asn Val Leu Ile Ile Leu Ala Ile Ser Phe Asp 35 40 45 Pro Arg Leu His Ala Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser Phe 50 55 60 Thr Asp Leu Phe Phe Val Thr Asn Thr Ile Pro Lys Met Leu Val Ser 65 70 75 80 Leu Gln Ser Gln Asn Lys Ala Ile Ser Tyr Ala Gly Cys Leu Thr Gln 85 90 95 Leu Tyr Phe Leu Val Ser Leu Val Ala Leu Asp Asn Leu Ile Leu Ala 100 105 110

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Thr Met Ala Tyr Asp Arg 115 Tyr Val Ala Ile Cys Arg Pro Leu His Tyr 120 125 Thr Thr Ala Met Ser Pro Gly Leu Cys Ile Leu Leu Leu Ala Leu Cys 130 135 140 Trp Ala Leu Ser Ala Leu Tyr Gly Leu Thr His Thr Leu Leu Met Thr 145 150 155 160 Arg Val Thr Phe Cys Gly Ser Arg Lys Ile His Tyr Ile Phe Cys Glu 165 170 175 Met Tyr Val Leu Leu Arg Leu Ala Cys Ser Asn Thr Gln Val Asn His 180 185 190 Thr Val Leu Ile Ala Thr Gly Cys Phe Ile Phe Leu Thr Pro Leu Gly 195 200 205 Phe Met Ile Met Ser Tyr Val 210 215

<210> 2067 <211> 948 <212> DNA <213> Canis familiaris <400> 2067 atggatccag aagttggagc caacaggaca tctgttactg agttcattct agtgggccta 60 gtggaaacag aacagctaca gtctgtggtc tttgtagtct tcctctttgc ctacctggtc 120 acagtcggag gcaacctcag catcctggct gccatcttgg tggaacccaa actccacaca 180 cccatgtact tcttcctggg gaacctgtca gtgctggatg ttgggtgcat cactgtcact 240 gttccctcaa tgttggctcg cctcctgtcc cacaaacgta cagttcccta cagggcctgc 300 ctcacacagc ttttcttctt tcaccttctg gctgggatgg actgcttcct gttgactgtc 360 atggcctatg accgattcct ggccatttgc cgacccctca cctacaacac ccacatgagc 420 cagaacgtcc agagaatatt ggtagctgtg tcctgggctt taggtttcac caatgcacta 480 aatcacacta ttgccctaac taccctcaac ttctgtggtc ctaatatagt caataacttc 540

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tactgtgacc tcccacagct cttccagctc tcttgctcta gcacccagct caacgagttg 600 ctgctctttg tggcagcagc cttcatggct gtagccccct tggtcctcat cactgtgtcc 660 tatgcacagg tggcagctgc agttctacaa attcgttcag tggaaggcag gaataaggcc 720 ttttccacat gtggctccca cctcactgtg gtttgccttt tctatggtac tggtatcttc 780 aactacatgt gtcttggttc tgaagagtct tcagacaagg ataaaggggt tggggtcttc 840 aacactgtta tcaatcccat gctgaaccca cttatctaca gccttagaaa ccctgatgtt 900 caggatgccc tgtggcgggt atttgtgggg aggaagtcat tgacctaa 948

<210> 2068 <211> 315 <212> PRT <213> Canis familiaris <400> 2068

Met Asp Pro Glu Val Gly Ala Asn Arg Thr Ser Val Thr Glu Phe Ile 1 5 10 15 Leu Val Gly Leu Val Glu Thr Glu Gln Leu Gln Ser Val Val Phe Val 20 25 30 Val Phe Leu Phe Ala Tyr Leu Val Thr Val Gly Gly Asn Leu Ser Ile 35 40 45 Leu Ala Ala Ile Leu Val Glu Pro Lys Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Val Leu Asp Val Gly Cys Ile Thr Val Thr 65 70 75 80 Val Pro Ser Met Leu Ala Arg Leu Leu Ser His Lys Arg Thr Val Pro 85 90 95 Tyr Arg Ala Cys Leu Thr Gln Leu Phe Phe Phe His Leu Leu Ala Gly 100 105 110 Met Asp Cys Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Leu Ala 115 120 125

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Ile Cys Arg Pro Leu Thr Tyr Asn Thr His Met Ser Gln Asn Val Gln 130 135 140 Arg Ile Leu Val Ala Val Ser Trp Ala Leu Gly Phe Thr Asn Ala Leu 145 150 155 160 Asn His Thr Ile Ala Leu Thr Thr Leu Asn Phe Cys Gly Pro Asn Ile 165 170 175 Val Asn Asn Phe Tyr Cys Asp Leu Pro Gln Leu Phe Gln Leu Ser Cys 180 185 190 Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe Val Ala Ala Ala Phe 195 200 205 Met Ala Val Ala Pro Leu Val Leu Ile Thr Val Ser Tyr Ala Gln Val 210 215 220 Ala Ala Ala Val Leu Gln Ile Arg Ser Val Glu Gly Arg Asn Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Cys Leu Phe Tyr Gly 245 250 255 Thr Gly Ile Phe Asn Tyr Met Cys Leu Gly Ser Glu Glu Ser Ser Asp 260 265 270 Lys Asp Lys Gly Val Gly Val Phe Asn Thr Val Ile Asn Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Pro Asp Val Gln Asp Ala Leu 290 295 300 Trp Arg Val Phe Val Gly Arg Lys Ser Leu Thr 305 310 315

<210> 2069 <211> 948 <212> DNA

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069269_0225_SL.TXT <213> Canis familiaris <400> 2069

atgcagtcaa aatttggggc caatagcaca gccattactg agttcatcct gctgggcttg 60 gtggacacac cagggctaca accagttgtc tttgtagtct tcctctttgc ctacctggtc 120 acagtcggag gcaacctcag catcctggct gccatcttgg tggaacccaa actccacacg 180 cccatgtact tcttcctggg gaacctgtca gtgctggatg ttgggtgcat cactgtcact 240 gttccctcaa tgttggctcg cctcttgtcc cacaaacgta cagttcccta cagagcctgc 300 ctcacacaac tcttcttctt ccatctcttg gttggggtgg actgcttcct gttgacagcc 360 atggcctatg accgattcct ggccatctgc cggcccctca cctacagcac ccagatgagc 420 cagacagtcc agagaatatt ggtagttgtg tcctgggctt tagccttcac caatgcactg 480 acccacacag tagccatagc cacactcaac ttttgtggtc ctaatgtgat caaccacttc 540 tactgcgacc tcccacagct cttccagctc tcctgctcca gcactcagct caatgagctg 600 ctgctctttg ctgtgggttt cataatggca ggtaccccct tggctctcat catcacttcc 660 tatgcacatg tggcagctgc agtcctaaga atccgctctg ctgagggcag gaagaaagct 720 ttctctacat gtggctctca tctcactgtg gtagccatat tctatggttc aggtatattt 780 aattacatgc gactgggtac agccaagcat tcagacaagg ataaaggggt tggggtcttc 840 aacactgtca tcaaccccat gctgaatcca atcatttaca gcctcaggaa ccttgatgta 900 cagggtgccc tctggcgggt gctcagggga aggcagtcac tggcttga 948

<210> 2070 <211> 315 <212> PRT <213> Canis familiaris

<400> 2070 Gly Ala Asn Ser Thr Ala Ile Thr Glu Phe Ile Met 1 Gln Ser Lys Phe 5 10 15 Leu Leu Gly Leu Val Asp Thr Pro Gly Leu Gln Pro Val Val Phe Val 20 25 30 Val Phe Leu Phe Ala Tyr Leu Val Thr Val Gly Gly Asn Leu Ser Ile 35 40 45

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Leu Ala Ala Ile Leu Val Glu Pro Lys 55 Leu His Thr Pro Met Tyr Phe 60 50 Phe Leu Gly Asn Leu Ser Val Leu Asp Val Gly Cys Ile Thr Val Thr 65 70 75 80 Val Pro Ser Met Leu Ala Arg Leu Leu Ser His Lys Arg Thr Val Pro 85 90 95 Tyr Arg Ala Cys Leu Thr Gln Leu Phe Phe Phe His Leu Leu Val Gly 100 105 110 Val Asp Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Phe Leu Ala 115 120 125 Ile Cys Arg Pro Leu Thr Tyr Ser Thr Gln Met Ser Gln Thr Val Gln 130 135 140 Arg Ile Leu Val Val Val Ser Trp Ala Leu Ala Phe Thr Asn Ala Leu 145 150 155 160 Thr His Thr Val Ala Ile Ala Thr Leu Asn Phe Cys Gly Pro Asn Val 165 170 175 Ile Asn His Phe Tyr Cys Asp Leu Pro Gln Leu Phe Gln Leu Ser Cys 180 185 190 Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe Ala Val Gly Phe Ile 195 200 205 Met Ala Gly Thr Pro Leu Ala Leu Ile Ile Thr Ser Tyr Ala His Val 210 215 220 Ala Ala Ala Val Leu Arg Ile Arg Ser Ala Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ala Ile Phe Tyr Gly 245 250 255

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Ser Gly Ile Phe Asn Tyr Met Arg Leu Gly Thr Ala Lys His Ser Asp 260 265 270

Lys Asp Lys Gly Val Gly Val Phe Asn Thr Val Ile Asn Pro Met Leu 275 280 285

Asn Pro Ile Ile Tyr Ser Leu Arg Asn Leu Asp Val Gln Gly Ala Leu 290 295 300

Trp Arg Val Leu Arg Gly Arg Gln Ser Leu Ala 305 310 315 <210> 2071 <211> 951 <212> DNA <213> Canis familiaris <400> 2071 atggatgctg ccaatgagtc ctcagaggga agtcctggac agcagcagcc tctctttgtg ctgggtaatg gactcattgt ggctgccatc tacttcctgc tggcccatct gtcctttgcc aaaatgttgg ccaacttgtt ggcccacgac cagatgtact tcttctttgc cctgggtgta tatgaccgct atgtggccat ccggcacccc atgtgcacag ccctggtggg gactgcatgg atcctgttta tggcccgcct gtccttctgt gatcaccagc ctattcttag gctctcttgc ttcactgagg gcgccgcagt ggtggtcact gccatcgcag ctgcagtgct ccggctgccc acttgtggct cccacctggc agtggtgggc ttccagccca catcccggta tgaggcagag gccccgttca ctattcttgg caggccagcc gacctctgct cgctccatct actgacagct ctccactatg ctggtgtccc gcctcccacc tctgacatcc cccttcctgc tcagcctctg ctcttctatg cggggccgtg

tcctattggg attgacaaca 60 ccctgtatgt ggcaggtatc 120 cagcccttca tgcacccatg 180 ttacctctgt cactgtgccc 240 ccctggcggg ctgcctgacc 300 gtctcctggc cgccatggcc 360 ccacaagaat gtcccgggct 420 acctccactc cctcctgcat 480 aagtgccgca cttcttctgt 540 gccacatcca gctgctcatc 600 taattcttgc ctcctatggg 660 ggaggctccg cgctgtgtcc 720 ggacagtcat tgcggtctac 780 tggccactgt catgtacact 840

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951

069269_0225_SL.TXT gtagtcaccc ctatgctaaa ccctgttatc tacagcttcc ggaaccgcga catgcagggg gcgctccgat cacttttcac tggaagaagg atctcctcta gtgactccta a <210> 2072 <211> 316 <212> PRT <213> Canis familiaris <400> 2072

Met Asp Ala Ala Asn Glu Ser Ser Glu Gly Ala Pro Phe Ile Leu Leu 1 5 10 15 Gly Leu Thr Thr Ser Pro Gly Gln Gln Gln Pro Leu Phe Val Leu Phe 20 25 30 Leu Ala Leu Tyr Val Ala Gly Ile Leu Gly Asn Gly Leu Ile Val Ala 35 40 45 Ala Ile Gln Ala Ser Pro Ala Leu His Ala Pro Met Tyr Phe Leu Leu 50 55 60 Ala His Leu Ser Phe Ala Asp Leu Cys Phe Thr Ser Val Thr Val Pro 65 70 75 80 Lys Met Leu Ala Asn Leu Leu Ala His Asp Arg Ser Ile Ser Leu Ala 85 90 95 Gly Cys Leu Thr Gln Met Tyr Phe Phe Phe Ala Leu Gly Val Thr Asp 100 105 110 Ser Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Arg 115 120 125 His Pro Leu His Tyr Ala Thr Arg Met Ser Arg Ala Met Cys Thr Ala 130 135 140 Leu Val Gly Thr Ala Trp Leu Val Ser His Leu His Ser Leu Leu His 145 150 155 160 Ile Leu Phe Met Ala Arg Leu Ser Phe Cys Ala Ser His Gln Val Pro

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165 170 175

His Phe Phe Cys 180 Asp His Gln Pro Ile Leu Arg Leu Ser Cys Ser Asp 185 190 Ile Arg His Ile Gln Leu Leu Ile Phe Thr Glu Gly Ala Ala Val Val 195 200 205 Val Thr Pro Phe Leu Leu Ile Leu Ala Ser Tyr Gly Ala Ile Ala Ala 210 215 220 Ala Val Leu Arg Leu Pro Ser Ala Ser Gly Arg Leu Arg Ala Val Ser 225 230 235 240 Thr Cys Gly Ser His Leu Ala Val Val Gly Leu Phe Tyr Gly Thr Val 245 250 255 Ile Ala Val Tyr Phe Gln Pro Thr Ser Arg Tyr Glu Ala Glu Arg Gly 260 265 270 Arg Val Ala Thr Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285 Val Ile Tyr Ser Phe Arg Asn Arg Asp Met Gln Gly Ala Leu Arg Ser 290 295 300 Leu Phe Thr Gly Arg Arg Ile Ser Ser Ser Asp Ser 305 310 315

<210> 2073 <211> 960 <212> DNA <213> Canis familiaris <400> 2073 atgactacag agaacttcac ctggaccagg gttactccta ctgaattcat cctcctgggc atcacggatc gctgggacct acgagtgacc ctcttcctga ttttcctgcc agtctacctg gtcagcctgc tgggaaatgt gggcatggtg ctgctgatcc gtatggatgc ccggctccaa acacctatgt actttttcct ggccaacctc tccctgctgg atgcctgcta ttcctcagcc Page 2322

120

180

240

069269_0225_SL.TXT atcggcccca agatgctagt ggacttgctg tgtgccctcc agatgtttgt gtttgcaggg gccatggcct atgaccgcta tgtggccatc tctcggtgtg tatgcctggc cttgctggga tttgtccaca caaccctcac cttccgcctg ttcttctgtg atatccctcc actgctggcc ctcctcctct tcactgtctg tggcttcatc tcatatggtt tcattgctgg ggctgtgatt gcagcctcta cctgtggctc tcacctcaca ttcatgtacc tgcgtcccag ctccagctat ttctacactc ttgtcatccc agctctcaac gtcaaggagg cagtcagaaa gacttggagc <210> 2074 <211> 319 <212> PRT <213> Canis familiaris ctgccccacg ccactattcc ttacatagcc ctggctgatg ctgagtgttg cctgttggca agaaaccctc tcctctacac aacagccatg gcatcaggtc tgagtggggc agtgagtgcc aacttctgcc agtctcggga ggtcaacagc atctcttgca atgacaccag tctcaatgag cagacagcca ctgtgttggt cattgccgtg cgcatgcatt cggcagaagg ccgtcagcga gctgtggcca tgctgtacgg aacacttact gccctggata ccgacaagat ggcatctgtg ccgctcatct acagcctccg caacaaggag cgattctgct gccctggtcc agagcactaa

300

360

420

480

540

600

660

720

780

840

900

960

<400> 2074 Met Thr Thr Glu Asn Phe Thr Trp 1 5 Ile Leu Leu Gly 20 Ile Thr Asp Arg Leu Ile Phe 35 Leu Pro Val Tyr Leu 40 Met Val 50 Leu Leu Ile Arg Met 55 Asp Phe 65 Phe Leu Ala Asn Leu 70 Ser Leu

Thr Arg 10 Val Thr Pro Thr Glu 15 Phe Trp 25 Asp Leu Arg Val Thr 30 Leu Phe Val Ser Leu Leu Gly 45 Asn Val Gly Ala Arg Leu Gln 60 Thr Pro Met Tyr Leu Asp Ala 75 Cys Tyr Ser Ser Ala 80

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Ile Gly Pro Lys Met 85 Leu Val 069269_0225_SL.TXT Asp Leu Leu Leu Pro His 90 Ala Thr 95 Ile Pro Tyr Ile Ala Cys Ala Leu Gln Met Phe Val Phe Ala Gly Leu Ala 100 105 110 Asp Ala Glu Cys Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Arg Asn Pro Leu Leu Tyr Thr Thr Ala Met Ser Arg Cys Val 130 135 140 Cys Leu Ala Leu Leu Gly Ala Ser Gly Leu Ser Gly Ala Val Ser Ala 145 150 155 160 Phe Val His Thr Thr Leu Thr Phe Arg Leu Asn Phe Cys Gln Ser Arg 165 170 175 Glu Val Asn Ser Phe Phe Cys Asp Ile Pro Pro Leu Leu Ala Ile Ser 180 185 190 Cys Asn Asp Thr Ser Leu Asn Glu Leu Leu Leu Phe Thr Val Cys Gly 195 200 205 Phe Ile Gln Thr Ala Thr Val Leu Val Ile Ala Val Ser Tyr Gly Phe 210 215 220 Ile Ala Gly Ala Val Ile Arg Met His Ser Ala Glu Gly Arg Gln Arg 225 230 235 240 Ala Ala Ser Thr Cys Gly Ser His Leu Thr Ala Val Ala Met Leu Tyr 245 250 255 Gly Thr Leu Thr Phe Met Tyr Leu Arg Pro Ser Ser Ser Tyr Ala Leu 260 265 270 Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Ala 275 280 285

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Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala 290 295 300

Val Arg Lys Thr Trp Ser Arg Phe Cys Cys Pro Gly Pro Glu His 305 310 315 <210> 2075 <211> 930 <212> DNA <213> Canis familiaris <400> 2075

atgctgaggg aaaaccagag ccatatgcct gaattcctcc ttctgggact gaccagtgac 60 cccaaacagc aggggtggct ctttgccagc ttcctagcca tgtatctggt caatgtggct 120 ggtaactcag tcatcattgc agccatccgg agggatgcct gcctccacac ccccatgtac 180 ttcttgcttt ccagtctgtc cctggtggac atctgcttta caagtgccat tgtgccaagg 240 atgctggcaa acatgatgag caaaagcaag aaggtcccct ttgcccaatg cctcacacag 300 atgtgtttct ttgtggcctt tgggatcact gacagcttcc tcctggctgt catggctgtt 360 gaccgctaca cggccatctg caacccgctg ctttacagca tgaccatgag ccccaggcgc 420 tatctcctgc tggtgatggt gtcctgggtg ctgtcccatc tccactcact cacccacatg 480 attctcatgg cccgcctctc cttctgtggg cccaatgtca tccatcactt cttctgtgat 540 gtccagccac tgctgacact ctcctgctcg gacacctcta tcaatgagct tttggctttc 600 acagaaggct cctttgtgat catgagtccc ttcgccttga tcactgtctc ttatattttt 660 atcacccatg ctgttctgag ggtccgttct gagagaggca ggtacaaggt cttctccacc 720 tgtcggtcct acctcatagt tgtggcacta ttctatggga ccataatatt tgtgtacatt 780 cacccctcat ccacctactc agtgacaaag gaccatgtgg tcactgtcat ctatacagta 840 gttatcccca tgctgaaccc ttttatctat agtcttagga acaaggacat gaagcaggcc 900 ttgaaaaagc tcctcagaag ggtagaatag 930

<210> 2076 <211> 309 <212> PRT <213> Canis familiaris

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<400> 2076 Met 1 Leu Arg Glu Asn Gln Ser His Met Pro Glu Phe Leu Leu Leu Gly 5 10 15 Leu Thr Ser Asp Pro Lys Gln Gln Gly Trp Leu Phe Ala Ser Phe Leu 20 25 30 Ala Met Tyr Leu Val Asn Val Ala Gly Asn Ser Val Ile Ile Ala Ala 35 40 45 Ile Arg Arg Asp Ala Cys Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Ser Leu Ser Leu Val Asp Ile Cys Phe Thr Ser Ala Ile Val Pro Arg 65 70 75 80 Met Leu Ala Asn Met Met Ser Lys Ser Lys Lys Val Pro Phe Ala Gln 85 90 95 Cys Leu Thr Gln Met Cys Phe Phe Val Ala Phe Gly Ile Thr Asp Ser 100 105 110 Phe Leu Leu Ala Val Met Ala Val Asp Arg Tyr Thr Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ser Met Thr Met Ser Pro Arg Arg Tyr Leu Leu Leu 130 135 140 Val Met Val Ser Trp Val Leu Ser His Leu His Ser Leu Thr His Met 145 150 155 160 Ile Leu Met Ala Arg Leu Ser Phe Cys Gly Pro Asn Val Ile His His 165 170 175 Phe Phe Cys Asp Val Gln Pro Leu Leu Thr Leu Ser Cys Ser Asp Thr 180 185 190 Ser Ile Asn Glu Leu Leu Ala Phe Thr Glu Gly Ser Phe Val Ile Met 195 200 205

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Ser Pro Phe Ala Leu Ile Thr Val Ser Tyr Ile Phe Ile Thr His Ala 210 215 220 Val Leu Arg Val Arg Ser Glu Arg Gly Arg Tyr Lys Val Phe Ser Thr 225 230 235 240 Cys Arg Ser Tyr Leu Ile Val Val Ala Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Phe Val Tyr Ile His Pro Ser Ser Thr Tyr Ser Val Thr Lys Asp His 260 265 270 Val Val Thr Val Ile Tyr Thr Val Val Ile Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gln Ala Leu Lys Lys Leu 290 295 300 Leu Arg Arg Val Glu

305 <210> 2077 <211> 237 <212> DNA <213> Canis familiaris <400> 2077 aagagtcatg tgactgaatt cctctttctg ggactgacca gtgaccccaa acagcagggg 60 tggctctttg ccagcttcct agccatgtat ctggtcaatg tggctggcaa ctcagtcatc 120 attgcagcca tccagaggga tgcctgcctc cacaccccca tgtacttctt gttttccagt 180 ctggccctgg tggacatctg ctttacaaat gtcattgtgc caaggatgct ggcaaac 237 <210> 2078 <211> 79 <212> PRT <213> Canis familiaris <400> 2078

Lys Ser His Val Thr Glu Phe Leu Phe Leu Gly Leu Thr Ser Asp Pro 1 5 10 15

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Lys Gln Gln Gly Trp Leu Phe Ala Ser Phe Leu Ala Met Tyr Leu Val 20 25 30 Asn Val Ala Gly Asn Ser Val Ile Ile Ala Ala Ile Gln Arg Asp Ala 35 40 45 Cys Leu His Thr Pro Met Tyr Phe Leu Phe Ser Ser Leu Ala Leu Val 50 55 60 Asp Ile Cys Phe Thr Asn Val Ile Val Pro Arg Met Leu Ala Asn 65 70 75

<210> 2079 <211> 930 <212> DNA <213> Canis familiaris <400> 2079

atggaaacaa agaactatag cagcgaatca ggctttgtcc tcctgggcat ctcttccagt 60 cctcagctac agaaaccact ctttgccatc ttcctcatca tgtacctggt cactgtcgtg 120 ggcaatgtac tcatcatctt ggctatccag tctgactccc gactccatac tcctatgtac 180 tttttcctca gcaacttgtc cttcacagat atctgcttca caacagtgat tgtgcccaac 240 atgctggcaa acctactatc agagaccaag gttatctcct ttgtgggttg cctgatccag 300 atgtaattct tcatggcctt tgcgaatact gacagttacc ttctggcctc tatggccata 360 gataggctgg tggccatctg caaccccttc cactatgaaa gggtcgtgaa cccacggcgt 420 tgtctcctca tgctgctggg ctcttgcacc atctcccacc tgcactccct gctccgagtg 480 ctactcatgt cccgcctgtc cttctgtgcc tctcatgtca ttaagcactt tttttgtgat 540 acccaacctg tactaaagct atcctgctct gacacatcct ccaaccagat tgtggtcatg 600 actgagaccc tggccgtcat cacaaccccc ttcctgtgca tcctcttttc ctacctgcga 660 atcatcatca ctgtgctcag aattccctct gcagctggga agtggaaggc cttctctacc 720 tgtggctccc acctcactgt agtggctttg ttctatggga gtgtcatcta tgtctacttt 780 aggcccctgt ccatgtactc agtggtgaag gaccgggtag ccacagttat gtacacagta 840

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930

069269_0225_SL.TXT gtgacaccca tgctgaaccc tttcatctat agcctgagga acaaagatat gaagaggggt ttgattaaat taagggacag aattcactca <210> 2080 <211> 206 <212> PRT <213> Canis familiaris <400> 2080

Met Ala Phe Ala Asn Thr Asp Ser Tyr Leu Leu Ala Ser Met Ala Ile 1 5 10 15 Asp Arg Leu Val Ala Ile Cys Asn Pro Phe His Tyr Glu Arg Val Val 20 25 30 Asn Pro Arg Arg Cys Leu Leu Met Leu Leu Gly Ser Cys Thr Ile Ser 35 40 45 His Leu His Ser Leu Leu Arg Val Leu Leu Met Ser Arg Leu Ser Phe 50 55 60 Cys Ala Ser His Val Ile Lys His Phe Phe Cys Asp Thr Gln Pro Val 65 70 75 80 Leu Lys Leu Ser Cys Ser Asp Thr Ser Ser Asn Gln Ile Val Val Met 85 90 95 Thr Glu Thr Leu Ala Val Ile Thr Thr Pro Phe Leu Cys Ile Leu Phe 100 105 110 Ser Tyr Leu Arg Ile Ile Ile Thr Val Leu Arg Ile Pro Ser Ala Ala 115 120 125 Gly Lys Trp Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val 130 135 140 Ala Leu Phe Tyr Gly Ser Val Ile Tyr Val Tyr Phe Arg Pro Leu Ser 145 150 155 160 Met Tyr Ser Val Val Lys Asp Arg Val Ala Thr Val Met Tyr Thr Val

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069269_0225_SL.TXT 165 170 175 Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp 180 185 190 Met Lys Arg Gly Leu Ile Lys Leu Arg Asp Arg Ile His Ser 195 200 205

<210> 2081 <211> 933 <212> DNA <213> Canis familiaris <400> 2081

atggaaacaa agaactatag cagcgaatca ggctttgtcc tcctgggcat ctcttccagt 60 cctcagctac agaaaccact ctttgccatc ttcctcatca tgtacctggt cactgtcgtg 120 ggcaatgtac tcatcatctt ggttatccag tctgactccc ggctccatac tcctatgtac 180 tttttcctca gcaacttgtc cttcacagat atctgcttca caacagtgat tgtgcccaac 240 atgctggcaa acctactatc agagaccaag gttatctcct ttgtgggttg cctgatccag 300 atgtatttct tcatggcctt tgcaaacact gacagttacc ttctggcctc tatggccata 360 gataggctgg tggccatctg caaccccttc cactatgaaa gggtcatgaa cccacggcgt 420 tgtctcctca tgctgctggg ctcttgcacc atctcccacc tgcactccct gctccgagtg 480 ctactcatgt cccgcctgtc cttctgtgcc tctcatgtca ttaagcactt tttttgtgat 540 acccaacctg tactaaagct atcctgctct gacacatcct ccaaccagat tgtggtcatg 600 actgagaccc tggccgtcat cacaaccccc ttcctgtgca tcctcttttc ctacctgcga 660 atcatcatca ctgtgctcag aattccctct gcagctggga agtggaaggc cttctctacc 720 tgtggctccc acctcactgt agtggctttg ttctatggga gtgtcatcta tgtctacttt 780 aggcccctgt ccatgtactc agtggtgaag gaccgggtag ccacagttat gtacacagta 840 gtgacaccca tgctgaaccc cttcatctat agcctgagga acaaagatat gaagaggggt 900 ttgattaaat taagggacag aattcactca tag 933

<210> 2082 <211> 310

Page 2330

069269_0225_SL.TXT <212> PRT <213> Canis familiaris

<400> 2082 Met 1 Glu Thr Lys Asn Tyr Ser Ser 5 Glu Ser 10 Gly Phe Val Leu Leu 15 Gly Ile Ser Ser Ser Pro Gln Leu Gln Lys Pro Leu Phe Ala Ile Phe Leu 20 25 30 Ile Met Tyr Leu Val Thr Val Val Gly Asn Val Leu Ile Ile Leu Val 35 40 45 Ile Gln Ser Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Thr Asp Ile Cys Phe Thr Thr Val Ile Val Pro Asn 65 70 75 80 Met Leu Ala Asn Leu Leu Ser Glu Thr Lys Val Ile Ser Phe Val Gly 85 90 95 Cys Leu Ile Gln Met Tyr Phe Phe Met Ala Phe Ala Asn Thr Asp Ser 100 105 110 Tyr Leu Leu Ala Ser Met Ala Ile Asp Arg Leu Val Ala Ile Cys Asn 115 120 125 Pro Phe His Tyr Glu Arg Val Met Asn Pro Arg Arg Cys Leu Leu Met 130 135 140 Leu Leu Gly Ser Cys Thr Ile Ser His Leu His Ser Leu Leu Arg Val 145 150 155 160 Leu Leu Met Ser Arg Leu Ser Phe Cys Ala Ser His Val Ile Lys His 165 170 175 Phe Phe Cys Asp Thr Gln Pro Val Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190

Page 2331

Ser Ser Asn 195 Gln Ile Val Val 069269_0225_SL.TXT Met Thr Glu Thr Leu Ala 200 205 Val Ile Thr Thr Pro Phe Leu Cys Ile Leu Phe Ser Tyr Leu Arg Ile Ile Ile Thr 210 215 220 Val Leu Arg Ile Pro Ser Ala Ala Gly Lys Trp Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ala Leu Phe Tyr Gly Ser Val Ile 245 250 255 Tyr Val Tyr Phe Arg Pro Leu Ser Met Tyr Ser Val Val Lys Asp Arg 260 265 270 Val Ala Thr Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Arg Gly Leu Ile Lys Leu 290 295 300 Arg Asp Arg Ile His Ser

305 310 <210> 2083 <211> 963 <212> DNA <213> Canis familiaris <400> 2083

atgaggaggg agaaccagag cagcgtgtta gagtttctcc tcctggggct ccccatccag 60 ccagagcagc agcgcatgtt ctttgccctg ttcctgggca tgtacctgac cacggtgctt 120 gggaatctgc tcaccatcct actcatcaga ctggactctc acctccacac ccccatgtac 180 ttcttcctta gccacttggc cttctctgat gtctctttct catctgtcac tgtcccaacg 240 atgctgatga acatgcagac tcggcactta accgtctcct atgcggggtg catttcccag 300 atgtattttt tcatactttt tgtttgtctt gacaattttc ttcttgcagc gacagcatat 360 gacaggtatg tggccatctg tcagccactc cactacacca ctgtcatgag ggaggagctg 420

Page 2332

069269_0225_SL.TXT

tgtatcttac tggtggctgg atcctggttc ttctcgtgtg cccatgccct gttgcatact 480 ctccttctgt cacgcctgtc cttctgtgct gacaatacca tccctcattt cttttgtgat 540 ctcactgccc tcttgaagtt agcctgctca gatacttccc tcaatgagct agttatcttc 600 actgagaggg gagtgtttgc cttcctgtca ttttgtgcta ttttggcctc ctatatctat 660 gttggggcca ccatcctgag agtccctcca tcaagaggat ctgcaaagcc ctccatcaag 720 aggatctgca aagccttgtc tacctgtggc tcccacctcc ttgtggtgtt gtactatggg 780 actcttgcaa tgatttactt cattccttca tcaaacagtt ccaaggtcaa agacattatt 840 gcttcagttt tgtatacagt ggtgataccc atgttaaacc cttttatgta tggcctgagg 900 aacagggaca tgaaataagc tctgaggaca ctttacagga ggaaaatttt ttcttaccaa 960

gtg 963 <210> 2084 <211> 305 <212> PRT <213> Canis familiaris <400> 2084

Met Arg Arg Glu Asn Gln Ser Ser Val Leu Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Pro Ile Gln Pro Glu Gln Gln Arg Met Phe Phe Ala Leu Phe Leu 20 25 30 Gly Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Thr Ile Leu Leu 35 40 45 Ile Arg Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ala Phe Ser Asp Val Ser Phe Ser Ser Val Thr Val Pro Thr 65 70 75 80 Met Leu Met Asn Met Gln Thr Arg His Leu Thr Val Ser Tyr Ala Gly 85 90 95 Cys Ile Ser Gln Met Tyr Phe Phe Ile Leu Phe Val Cys Leu Asp Asn Page 233: 3

100

069269_0225_SL.TXT 105 110

Leu Leu Ala Ala Thr Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln 115 120 125

Leu His Tyr Thr Thr Val Met Arg Glu Glu Leu Cys Ile Leu Leu 130 135 140

Ala Gly Ser Trp Phe Phe Ser Cys Ala His Ala Leu Leu His Thr 150 155 160

Leu Leu Ser Arg Leu Ser Phe Cys Ala Asp Asn Thr Ile Pro His 165 170 175

Phe Cys Asp Leu Thr Ala Leu Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190

Leu Asn Glu Leu Val Ile Phe Thr Glu Arg Gly Val Phe Ala Phe 195 200 205

Ser Phe Cys Ala Ile Leu Ala Ser Tyr Ile Tyr Val Gly Ala Thr 210 215 220

Leu Arg Val Pro Pro Ser Arg Gly Ser Ala Lys Pro Ser Ile Lys 230 235 240

Ile Cys Lys Ala Leu Ser Thr Cys Gly Ser His Leu Leu Val Val 245 250 255

Tyr Tyr Gly Thr Leu Ala Met Ile Tyr Phe Ile Pro Ser Ser Asn 260 265 270

Ser Lys Val Lys Asp Ile Ile Ala Ser Val Leu Tyr Thr Val Val 275 280 285

Pro Met Leu Asn Pro Phe Met Tyr Gly Leu Arg Asn Arg Asp Met 290 295 300

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069269_0225_SL.TXT

305 <210> 2085 <211> 945 <212> DNA <213> Canis familiaris <400> 2085

atggcaaggg tcaaccaaac cagcagtgtc tctgagttca ttctcctggg actctcctcc 60 cagcctgagg accagaagcc actctttatc ctcttcctca ccatgtacct gatcaccata 120 atagggaacc tactcatcat cctggccatc cattctgatc cccagctcca gacccccatg 180 tatttcttct tgagtttcct gtccttcact gatatttgct ttacaacaac tgttgtcccc 240 aggatgctag tgagcttcct ttctaagaag accatctcct atgctgggtg tctgacacag 300 atgtatttca tttatgctct gggcaacacc gacagctgcc ttctggcagt catggccttt 360 gaccgctatg tggctatctg tgaccccttc cactacgtca ccaccatgaa ccgccgctgc 420 tgtgtcctgc tggtggcctt ttcctgctca cttccccact tccactcact cgtacacaca 480 ctgctactga acagcctcac tttctgtgac tccaatgtca tccaccactt cctctgtgac 540 ctcagtccct tgatgaaatt gtcctgttcc tccacatttg tcaatgaagt tgtgataata 600 tcagaaggtt ctgttgtttt ggtgactcca tttctgtgca tcactctctc ttatgtacga 660 attctcatcg cagttcttaa gatcccttca gctgctggga aacgcaaagc cttctccacc 720 tgtggctctc acctcaccgt ggtcacactc ttttatggaa gcatcttcta tgtctattta 780 cagcccctgt ccacctacag tgccagggac cacatagcaa caattgtcta cacagttctt 840 tcctccatgc taaacccttt tatctacagc ctgagaaaca aagacctgaa acagagccta 900 aggaagctga tgggcaggtg gaattctcaa gcaacaccct cttga 945

<210> 2086 <211> 314 <212> PRT <213> Canis familiaris <400> 2086

Met Ala Arg Val Asn Gln Thr Ser Ser Val Ser Glu Phe Ile Leu Leu 1 5 10 15

Page 2335

069269_0225_SL.TXT

Gly Leu Ser Ser 20 Gln Pro Glu Asp Gln Lys Pro Leu Phe Ile Leu Phe 25 30 Leu Thr Met Tyr Leu Ile Thr Ile Ile Gly Asn Leu Leu Ile Ile Leu 35 40 45 Ala Ile His Ser Asp Pro Gln Leu Gln Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Phe Leu Ser Phe Thr Asp Ile Cys Phe Thr Thr Thr Val Val Pro 65 70 75 80 Arg Met Leu Val Ser Phe Leu Ser Lys Lys Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Met Tyr Phe Ile Tyr Ala Leu Gly Asn Thr Asp Ser 100 105 110 Cys Leu Leu Ala Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asp 115 120 125 Pro Phe His Tyr Val Thr Thr Met Asn Arg Arg Cys Cys Val Leu Leu 130 135 140 Val Ala Phe Ser Cys Ser Leu Pro His Phe His Ser Leu Val His Thr 145 150 155 160 Leu Leu Leu Asn Ser Leu Thr Phe Cys Asp Ser Asn Val Ile His His 165 170 175 Phe Leu Cys Asp Leu Ser Pro Leu Met Lys Leu Ser Cys Ser Ser Thr 180 185 190 Phe Val Asn Glu Val Val Ile Ile Ser Glu Gly Ser Val Val Leu Val 195 200 205 Thr Pro Phe Leu Cys Ile Thr Leu Ser Tyr Val Arg Ile Leu Ile Ala 210 215 220

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069269_0225_SL.TXT

Val 225 Leu Lys Ile Pro Ser Ala 230 Ala Gly Lys Arg Lys Ala Phe Ser Thr 235 240 Cys Gly Ser His Leu Thr Val Val Thr Leu Phe Tyr Gly Ser Ile Phe 245 250 255 Tyr Val Tyr Leu Gln Pro Leu Ser Thr Tyr Ser Ala Arg Asp His Ile 260 265 270 Ala Thr Ile Val Tyr Thr Val Leu Ser Ser Met Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Leu Lys Gln Ser Leu Arg Lys Leu Met 290 295 300 Gly Arg Trp Asn Ser Gln Ala Thr Pro Ser 305 310

<210> 2087 <211> 981 <212> DNA <213> Canis familiaris <400> 2087

atggagaagg tcaaccaaac cagcagtgtc tccaagttcc tcctcggact ctccttctct 60 cctgaggacc agaagccatt cttttccctg ttcttcatca tgtacatggt cactctggga 120 gggaacctgc tcatcaccct agccatctgc tctgacactc agctccagac acctatgtat 180 tttttttttt tcctcagcat attatccttc attgacattt gctacaccac aaccatcatt 240 cccaagatgc tggtgaactt cctatcagaa aaagaagccc atctcctacg ctgagtgtat 300 gacccagatg tatttcttct tggcttttgc caacacagaa agtttcctgg cgaccatggc 360 cattgatcgc tttgtggcta tctgtgaccc cttccattat gtcaccacca tgagccactg 420 ccactgtctc ctgctgcttg ccttctcctg ctccatccct gacctccatt ccctcttact 480 tgttcttctg gtgaatgcct cactttctgt gactccaatg ttataccccc acttcctctg 540 caacatcaac tctctgctga aattgtcctg ctcaaaaaaa aaaaaaaaaa aaaaaagaaa 600 ttgtcctgct cttccacatt tgtcaatgaa gttgtaatta acacagaatg attgataaca 660

Page 2337

069269_0225_SL.TXT ctgatgaccc cctttatatg tgttatcatc tcttacttct gggtcctcat tgctattctt aagatcccct cagctgctcg gaagcataaa gctttctcta actatggctc ccacctcacc atggtgactc tcttttatgg aagtattatt tatgtttatt tctgacctct gtccagctat acaatcaagg acagggtggt gacagtcatc tacacagttc tgtcctccat gctgaaccct ttaatctaca gcctgaggaa caaagacatg aagtggggca tgagaaagct gatgggcagc tttcagtccc agacagcacc t

720

780

840

900

960

981 <210> 2088 <211> 97 <212> PRT <213> Canis familiaris

<400> 2088 Asn Gln 5 Thr Ser Ser Val Ser Lys Phe Leu Leu Gly Met Glu 1 Lys Val 10 15 Leu Ser Phe Ser Pro Glu Asp Gln Lys Pro Phe Phe Ser Leu Phe Phe 20 25 30 Ile Met Tyr Met Val Thr Leu Gly Gly Asn Leu Leu Ile Thr Leu Ala 35 40 45 Ile Cys Ser Asp Thr Gln Leu Gln Thr Pro Met Tyr Phe Phe Phe Phe 50 55 60 Leu Ser Ile Leu Ser Phe Ile Asp Ile Cys Tyr Thr Thr Thr Ile Ile 65 70 75 80 Pro Lys Met Leu Val Asn Phe Leu Ser Glu Lys Glu Ala His Leu Leu 85 90 95

Arg <210> 2089 <211> 945 <212> DNA <213> Canis familiaris

Page 2338

069269_0225_SL.TXT <400> 2089

atgggaaata ataatgtgac agaatttgtc ctccttggcc tcactcagga tcctgagggg 60 cagaaagcat tatttgtcat gattttactc atctacattg tgacaatggt gggcaaccta 120 ctcattgtag tgactgtttt tggcagcccc tctctgggct cccccatgta ctttttcctt 180 gcctatctgt cacttatgga tgctgtttat tccactgtca tttcacccaa attgattata 240 gacttactct gtgacaaaaa gacaatttct ttcccagctt gcatgggtca gctctttcta 300 gaacacttct ttgggggttc tgaggtcttc cttctggtca tgatggccta tgatcgctat 360 gtggccatct gtaggccact gcattacctg actgttatga atcgacaggt ttgcatcctg 420 ctgatagtgg tggcctggat tggaggtctt gtgcactcta tggttcagct tctctttgtg 480 tacagcctcc cattttgtgg ctccaatgtc attgatcact ttatctgtga actgtaccca 540 ttattagaac ttgcctgcac tgacacctac ttaataggcc tcactgtgat tgccaacggt 600 ggagcaatct gtatggtcat ctttatcctt ctactcatct cctatggagt cattctaaat 660 tctcttaaaa gtcacagtcc agaagggagg cgcaaagccc tgtctacctg cagttcccac 720 accacagtgg ttgtcctttt ttttgttccc tgcatttgca tgtatgttag acctgtttct 780 aacttgccca ttgataagtc tgtaactctg gtttatacag ttatcactcc catgttatat 840 cctttaatat ataccttgag aaattcagag atgaaaaatg ctatggaaaa attctggtgt 900 aaaaatttaa caaaaggtag aataagaatg tgtcacctaa actga 945

<210> 2090 <211> 314 <212> PRT <213> Canis familiaris <400> 2090

Met 1 Gly Asn Asn Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr Gln 5 10 15 Asp Pro Glu Gly Gln Lys Ala Leu Phe Val Met Ile Leu Leu Ile Tyr 20 25 30 Ile Val Thr Met Val Gly Asn Leu Leu Ile Val Val Thr Val Phe Gly 35 40 45

Page 2339

Ser Pro 50 Ser Leu Gly Ser Pro 55 069269_0225_SL.TXT Met Tyr Phe Phe Leu Ala 60 Tyr Leu Ser Leu Met Asp Ala Val Tyr Ser Thr Val Ile Ser Pro Lys Leu Ile Ile 65 70 75 80 Asp Leu Leu Cys Asp Lys Lys Thr Ile Ser Phe Pro Ala Cys Met Gly 85 90 95 Gln Leu Phe Leu Glu His Phe Phe Gly Gly Ser Glu Val Phe Leu Leu 100 105 110 Val Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu His 115 120 125 Tyr Leu Thr Val Met Asn Arg Gln Val Cys Ile Leu Leu Ile Val Val 130 135 140 Ala Trp Ile Gly Gly Leu Val His Ser Met Val Gln Leu Leu Phe Val 145 150 155 160 Tyr Ser Leu Pro Phe Cys Gly Ser Asn Val Ile Asp His Phe Ile Cys 165 170 175 Glu Leu Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr Leu Ile 180 185 190 Gly Leu Thr Val Ile Ala Asn Gly Gly Ala Ile Cys Met Val Ile Phe 195 200 205 Ile Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu Asn Ser Leu Lys Ser 210 215 220 His Ser Pro Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser Ser His 225 230 235 240 Thr Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Cys Met Tyr Val 245 250 255

Page 2340

069269_0225_SL.TXT

Arg Pro Val Ser Asn Leu Pro Ile Asp Lys 265 Ser Val Thr Leu 270 Val Tyr 260 Thr Val Ile Thr Pro Met Leu Tyr Pro Leu Ile Tyr Thr Leu Arg Asn 275 280 285 Ser Glu Met Lys Asn Ala Met Glu Lys Phe Trp Cys Lys Asn Leu Thr 290 295 300 Lys Gly Arg Ile Arg Met Cys His Leu Asn 305 310

<210> 2091 <211> 933 <212> DNA <213> Canis familiaris <400> 2091

atggaaaaac acaatctgac catgctcaat gaattcattc tcatgggaat cacacatcgt 60 cctgagctgc aggctccatt atttgggctc ttctttgtca tctatttgat ctccgtggtg 120 ggcaacctgg gcatgatcat cctcaccaaa gtggatgcca gactacaaac acccatgtac 180 ttcttcctca aacacctggc ttttactgac cttggttatt caacaactgt gggacccaaa 240 atgttagtaa attttattgt ggatcaaagt acaatctcct attacttttg tgctatgcaa 300 ctagctttct ttcttgtgtt tattatcagt gaacttttca ttctgtcagc tatgtcctat 360 gaccgctatg tagccatctg taaccctctg ctctaccccc tcatcatgtc acagagggtg 420 tgtcaggtgc tggtggcaat cccttatctc tacagcacat ttgtgtctct tctagtcacc 480 ataaagattt ttagttcatt cttctgtggc tacaatgttg taaatcattt ctactgtgac 540 tgtctcccct tgttatcttt gctctgctca aatacacatg aaattgagtt gatgattttg 600 attttctcag tttttgatgt cagttcatcc cttctgataa ttcttgtgtc ttacctgctg 660 atcctggtag ccattgtcag gatgaattca gctaagggta ggctcaaggc tttttccacc 720 tgtggatccc acctgacagt ggccacagtg ttctatggga ctttgatatt tatgtatgtg 780 caacctgagt ccagccattc ctttgacact gataaagtgg cgtccatatt ttacaccctc 840 gttatcccca tgctgaatcc cttgatctat agcttgagga acaaagatgt aaaatatgca 900

Page 2341

933

069269_0225_SL.TXT gtgcaaacaa tgtggaaaaa aactatgcaa taa <210> 2092 <211> 310 <212> PRT <213> Canis familiaris

<400> 2092 Met Glu Lys His Asn Leu Thr Met Leu Asn Glu Phe Ile Leu Met Gly 1 5 10 15 Ile Thr His Arg Pro Glu Leu Gln Ala Pro Leu Phe Gly Leu Phe Phe 20 25 30 Val Ile Tyr Leu Ile Ser Val Val Gly Asn Leu Gly Met Ile Ile Leu 35 40 45 Thr Lys Val Asp Ala Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Lys 50 55 60 His Leu Ala Phe Thr Asp Leu Gly Tyr Ser Thr Thr Val Gly Pro Lys 65 70 75 80 Met Leu Val Asn Phe Ile Val Asp Gln Ser Thr Ile Ser Tyr Tyr Phe 85 90 95 Cys Ala Met Gln Leu Ala Phe Phe Leu Val Phe Ile Ile Ser Glu Leu 100 105 110 Phe Ile Leu Ser Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Pro Leu Ile Met Ser Gln Arg Val Cys Gln Val Leu 130 135 140 Val Ala Ile Pro Tyr Leu Tyr Ser Thr Phe Val Ser Leu Leu Val Thr 145 150 155 160 Ile Lys Ile Phe Ser Ser Phe Phe Cys Gly Tyr Asn Val Val Asn His 165 170 175

Page 2342

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Phe Tyr Cys Asp Cys Leu Pro Leu Leu Ser Leu Leu Cys Ser Asn Thr 180 185 190 His Glu Ile Glu Leu Met Ile Leu Ile Phe Ser Val Phe Asp Val Ser 195 200 205 Ser Ser Leu Leu Ile Ile Leu Val Ser Tyr Leu Leu Ile Leu Val Ala 210 215 220 Ile Val Arg Met Asn Ser Ala Lys Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Ala Thr Val Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Met Tyr Val Gln Pro Glu Ser Ser His Ser Phe Asp Thr Asp Lys 260 265 270 Val Ala Ser Ile Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Tyr Ala Val Gln Thr Met 290 295 300 Trp Lys Lys Thr Met Gln

305 310 <210> 2093 <211> 861 <212> DNA <213> Canis familiaris <400> 2093 agggatccaa gaaaacagaa agcagtattt ggtgtcttct tgatgtttta ccttgccaca ctgttgggaa actttctcat tgtagtgact attaaaagaa gcaggaccct tgggagtccc atgtacttct tcctatttta cctgtctttt actgatgctt gcctctctac aaccattgcc cccagattga ttgtggatgc catttctcag aggaagacca tttcctacaa tgagtgcatg actcaagtct tttcagccca cttctttgga tgcatggaaa tcttcgtgct gatcctgatg

120

180

240

300

Page 2343

069269_0225_SL.TXT

gcttttgatc gctatgtagc catttgtaag cccttgtgat acacaaccat catgaacagg 360 catgtctgca gtgtgctggt gattctgggt tgggtgggat cctgtatcca ctcttcagca 420 caaattttcc tggcttcgag attgcctttc tgtggtccca atgtgattga tcactatttc 480 tgtgacttgc agcccttgtt gaaacttgct tgcatggaca cttatgtaat aaatttgcta 540 gttgtttcta acagtggagc catatgcacg gtgagtttca taattctgct tatctcctat 600 gttatcatct tgtactctct gagaaactac agtgcagaag gaaggcgaaa agccctttcg 660 acctgcacct cccattttat tgtggttgtc ctattttttg gcccatgtat attcatgtat 720 acacgcccgg caaccacatt tccagtagac aaggtggtgg cagtgtttta taccattggg 780 acacctttgc tgaaccctct gatctataca ctgaggaatg cggaagtgaa aaatgccatg 840 aaaaagttat ggtgtagcaa a 861

<210> 2094 <211> 170 <212> PRT <213> Canis familiaris <400> 2094

Met Asn 1 Arg His Val 5 Cys Ser Val Leu Val Ile Leu Gly Trp Val Gly 10 15 Ser Cys Ile His Ser Ser Ala Gln Ile Phe Leu Ala Ser Arg Leu Pro 20 25 30 Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe Cys Asp Leu Gln Pro 35 40 45 Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val Ile Asn Leu Leu Val 50 55 60 Val Ser Asn Ser Gly Ala Ile Cys Thr Val Ser Phe Ile Ile Leu Leu 65 70 75 80 Ile Ser Tyr Val Ile Ile Leu Tyr Ser Leu Arg Asn Tyr Ser Ala Glu 85 90 95

Page 2344

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Gly Arg Arg Lys Ala 100 Leu Ser Thr Cys Thr 105 Ser His Phe Ile 110 Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Met Tyr Thr Arg Pro Ala Thr 115 120 125 Thr Phe Pro Val Asp Lys Val Val Ala Val Phe Tyr Thr Ile Gly Thr 130 135 140 Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Ala Glu Val Lys 145 150 155 160 Asn Ala Met Lys Lys Leu Trp Cys Ser Lys 165 170

<210> 2095 <211> 915 <212> DNA <213> Canis familiaris <400> 2095

atggtgatga atagcactgt gaatgaattc attctgtttg gcttgacaca ggatccaaga 60 aaacagaaag cagtatttgg ggtcttcttg atgttttacc ttgccacact gttgggaaac 120 tttctcattg tagtgactat taaaagaagc aggacccttg ggagtcccat gtacttcttc 180 ctattttacc tgtcttttac tgatgcttgc ctctctacaa ccattgcccc cagattgatt 240 gtggatgcca tttctcagag gaagaccatt tcctacaatg agtgcatgac tcaagtcttt 300 tcagcccact tctttggatg caaggaaatc ttcgtgctga tcctgatggc ttttgatcgc 360 tatgtagcca tttgtaagcc cttgcgatac acaaccatca tgaacaggca tgtctgcagt 420 gtgctggtga ttctgggttg ggtgggatcc tgtatccact cttcagcaca aattttcctg 480 gcttcgagat tgcctttctg tggtcccaat gtgattgatc actatttctg tgacttgcag 540 cccttgttga aacttgcttg catggacact tatgtaataa atttgctagt tgtttctaac 600 agtggagcca tatgcacggt gagtttcata atcctgctta tctcctatgt tatcatcttg 660 tactctctga gaaactacag tgcagaagga aggcgaaaag ccctttcgac ctgcacctcc 720 cattttattg tggttgtcct attttttggc ccatgtatat tcatatatac acgcccagca 780

Page 2345

069269_0225_SL.TXT accacatttc cagtagacaa ggtggtggct gtattttata ccattggggc acccttgctc aaccctctga tctatacact gaggaatgcg gaagtgaaaa atgccatgaa aaagttatgg tgtaacaaag tgtga

840

900

915 <210> 2096 <211> 304 <212> PRT <213> Canis familiaris <400> 2096

Met Val 1 Met Asn Ser Thr Val Asn Glu Phe Ile Leu Phe Gly Leu Thr 5 10 15 Gln Asp Pro Arg Lys Gln Lys Ala Val Phe Gly Val Phe Leu Met Phe 20 25 30 Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45 Arg Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Thr Asp Ala Cys Leu Ser Thr Thr Ile Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Ile Ser Gln Arg Lys Thr Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ser Ala His Phe Phe Gly Cys Lys Glu Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Asn Arg His Val Cys Ser Val Leu Val Ile 130 135 140 Leu Gly Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Phe Leu 145 150 155 160

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Ala Ser Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Val Val Ser Asn Ser Gly Ala Ile Cys Thr Val Ser 195 200 205 Phe Ile Ile Leu Leu Ile Ser Tyr Val Ile Ile Leu Tyr Ser Leu Arg 210 215 220 Asn Tyr Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Phe Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Ala Thr Thr Phe Pro Val Asp Lys Val Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Ala Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Cys Asn Lys Val 290 295 300

<210> 2097 <211> 930 <212> DNA <213> Canis familiaris <400> 2097 atgactgagg ataattactc cttgacaact gaatttattc tcataggatt tacagatcac ccaaagttga agaccgttct gtttgtggtg tttctcacta tctatctggt gaccatggtg gggaatctgg gcctggtggc attgatcctt atggagcgtc gccttcacac acccatgtac atctttctgg gcaacctggc tctaatggat tcctgttgtg cctgtgccat tacccccaag atgttagaga atttcttttc gaaggacaga atgatttccc tctatgaatg catggcacag

120

180

240

300

Page 2347

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ttttattttc tctgccttgc tgaaacggca gactgctttc tcctggcagc aatggcctat 360 gaccgctatg tggccatctg cagcccactg cagtaccaca ccctgatgtc gaagaagctc 420 tgccttcaga tgaccgcagg ggcctacata gcaggaaacc tgcattccat gattcatata 480 gtgtttctct ttcgtttaac tttctgtagg tctcatcaga ttaatcactt tttttgtgat 540 gttcttccat tattcaaact ctcctgtgtt gacccttata tcaatgaatt gttgatattt 600 atcttttctg gttcagttca agtcttctct attatcatag tcataatctc ttatctctgc 660 atccttttca tgattttcaa aatgaaatcc aaagagggaa gaggcaaagc cttatctact 720 tgtgcatcac actttctctc tgtctcaatg ttctatggtt ctcttctctt tgtgtacgtt 780 cgaccaaatt cagttaaaga ggaggataaa gatatacctg ttgctatttt ttatactcta 840 gtaatccctt tattaaaccc ttttatttat agtctaagaa ataaggaagt aataaatgcc 900 atgaaaagaa atataaagaa aattttataa 930

<210> 2098 <211> 309 <212> PRT <213> Canis familiaris

<400> 2098 Asn Tyr 5 Ser Leu Thr Thr Glu Phe Ile Leu Ile Gly Met Thr 1 Glu Asp 10 15 Phe Thr Asp His Pro Lys Leu Lys Thr Val Leu Phe Val Val Phe Leu 20 25 30 Thr Ile Tyr Leu Val Thr Met Val Gly Asn Leu Gly Leu Val Ala Leu 35 40 45 Ile Leu Met Glu Arg Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ala Leu Met Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Glu Asn Phe Phe Ser Lys Asp Arg Met Ile Ser Leu Tyr Glu 85 90 95

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Cys Met Ala Gln Phe Tyr Phe Leu Cys Leu Ala Glu Thr Ala 110 Asp Cys 100 105 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Gln Tyr His Thr Leu Met Ser Lys Lys Leu Cys Leu Gln Met 130 135 140 Thr Ala Gly Ala Tyr Ile Ala Gly Asn Leu His Ser Met Ile His Ile 145 150 155 160 Val Phe Leu Phe Arg Leu Thr Phe Cys Arg Ser His Gln Ile Asn His 165 170 175 Phe Phe Cys Asp Val Leu Pro Leu Phe Lys Leu Ser Cys Val Asp Pro 180 185 190 Tyr Ile Asn Glu Leu Leu Ile Phe Ile Phe Ser Gly Ser Val Gln Val 195 200 205 Phe Ser Ile Ile Ile Val Ile Ile Ser Tyr Leu Cys Ile Leu Phe Met 210 215 220 Ile Phe Lys Met Lys Ser Lys Glu Gly Arg Gly Lys Ala Leu Ser Thr 225 230 235 240 Cys Ala Ser His Phe Leu Ser Val Ser Met Phe Tyr Gly Ser Leu Leu 245 250 255 Phe Val Tyr Val Arg Pro Asn Ser Val Lys Glu Glu Asp Lys Asp Ile 260 265 270 Pro Val Ala Ile Phe Tyr Thr Leu Val Ile Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Asn Ala Met Lys Arg Asn 290 295 300

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Ile Lys Lys Ile Leu 305 <210> 2099 <211> 663 <212> DNA <213> Canis familiaris <400> 2099

atgtgtatac ccttgattaa caatacagtt agctataatc cttgtgccac tcaattattt 60 tttgttattg tcttgggtgt gactgaaatt tgcctcctca cagccatgtc ctataaccgc 120 tatgtggcca tctgcaaacc cctgcattac atgaccatca tgaacaacag ggtctgcatc 180 aagttcctta ttggatgtta tacgttagtt ctgctcatcg tcctcccacc ctatatcatg 240 ggcttcaagc tcgagttttg tgactccaat gtcatagatc actttggctg tgatgctgct 300 cccatcctga agattacctg ctcagacaca gagtttatcg agcgatttgt cttggtcctg 360 gctgtgttga cactcatttt caccttggtg tgtgtaattt tgtcctacac atacatcatc 420 aggacaattc tcagatttcc ttctgtccag caaaggaaaa aggcttttac tacttgttct 480 tcccatataa ttgtggtttc tattacttat ggaagctgca tctttatcta tatcaaacct 540 catgcaaaag aaggggttgc tattaataag gtggtgtcag tgcttaccac ctcagttgcc 600 ccagtgatga atccctttat ttatactctg aggaacaagc aagtgactga agctttcaaa 660

gac 663 <210> 2100 <211> 221 <212> PRT <213> Canis familiaris

<400> 2100 Met Cys Ile Pro Leu Ile Asn Asn Thr Val Ser Tyr Asn Pro Cys Ala 1 5 10 15 Thr Gln Leu Phe Phe Val Ile Val Leu Gly Val Thr Glu Ile Cys Leu 20 25 30 Leu Thr Ala Met Ser Tyr Asn Arg Tyr Val Ala Ile Cys Lys Pro Leu Page 235 0

069269_0225_SL.TXT

His Tyr Met 50

Gly Cys Tyr 65

Gly Phe Lys

Cys Asp Ala

Ile Glu Arg 115

Leu Val Cys 130

Arg Phe Pro 145

Ser His Ile

Tyr Ile Lys

Ser Val Leu 195

Thr Leu Arg 210 <210> 2101 <211> 945 <212> DNA <213> Canis

40 Thr Ile Met Asn Asn Arg Val Cys 45 Ile 60 Lys Phe Leu Ile 55 Thr Leu Val Leu Leu Ile Val Leu Pro Pro Tyr Ile Met 70 75 80 Leu Glu Phe Cys Asp Ser Asn Val Ile Asp His Phe Gly 85 90 95 Ala Pro Ile Leu Lys Ile Thr Cys Ser Asp Thr Glu Phe 100 105 110 Phe Val Leu Val Leu Ala Val Leu Thr Leu Ile Phe Thr 120 125 Val Ile Leu Ser Tyr Thr Tyr Ile Ile Arg Thr Ile Leu 135 140 Ser Val Gln Gln Arg Lys Lys Ala Phe Thr Thr Cys Ser 150 155 160 Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile 165 170 175 Pro His Ala Lys Glu Gly Val Ala Ile Asn Lys Val Val 180 185 190 Thr Thr Ser Val Ala Pro Val Met Asn Pro Phe Ile Tyr 200 205 Asn Lys Gln Val Thr Glu Ala Phe Lys Asp 215 220 familiaris

Page 2351

069269_0225_SL.TXT <400> 2101 atgttgggga atcagtctag tgccactgaa ttttatctcc ttggcttccc tggctccaag 60 gaactacacc atcttctctt tgctaccttc ttcttcttct actcagtgac attaatggga 120 aacatggtca tcatcttgat tgtgtgtgct gataaacgtc tgcagtcccc catgtatttc 180 ttccttggtc acctctctgc cttggagatc ttggttacat ctgttattgt gcctgtgatg 240 ctttgggggt tgctgctccc tgggatgcag acgatatctt tggctgcatg tgtcacccag 300 ctcttcctgt acctttctct ggggaccacc gagtttgcat tactgggagc aatggctgtg 360 gaccgttatg tggctgtctg taaccctttg aggtacaatg tcattatgaa cagccgcacc 420 tgtatctggg tggtcattgt gtcatgggtg tttggtttcc tatttcaaat ctggccagtg 480 tatgccacat ttcagcttac gttctgcaaa tccaatgtgg tgaacaattt cttctgtgac 540 cgagggcaat tgctcaaact atcctgcaac aatactcttt tcatagagtt tattctattc 600 ctaatggctg tctttgttct ttttggttct ctgatcccta caatcatctc ctacacctac 660 atcatctcca ccatcctcaa gattccctca gcctctgggc gaaggaaagc cttttctacg 720 tgtgcgtccc acttcacttg tgttgtgatc ggctatggca gttgcttgtt cctctatgtg 780 aaacccaagc aaacacaggc ggcagattac aatagagtgg tttccttgat ggtttcagtg 840 gttactcctt tcctcaaccc tttcatcttc acccttcgaa atgacaaagt catagaagcc 900 ctatgggatg gaatgaaaag atgctgtcaa ctattcaata actaa 945 <210> 2102 <211> 314 <212> PRT <213> Canis familiaris <400> 2102

Met 1 Leu Gly Asn Gln 5 Ser Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe 10 15 Pro Gly Ser Lys Glu Leu His His Leu Leu Phe Ala Thr Phe Phe Phe 20 25 30 Phe Tyr Ser Val Thr Leu Met Gly Asn Met Val Ile Ile Leu Ile Val 35 40 45

Page 2352

Cys Ala 50 Asp Lys Arg Leu Gln 55 069269_0225_SL.TXT Ser Pro Met Tyr Phe Phe 60 Leu Gly His Leu Ser Ala Leu Glu Ile Leu Val Thr Ser Val Ile Val Pro Val Met 65 70 75 80 Leu Trp Gly Leu Leu Leu Pro Gly Met Gln Thr Ile Ser Leu Ala Ala 85 90 95 Cys Val Thr Gln Leu Phe Leu Tyr Leu Ser Leu Gly Thr Thr Glu Phe 100 105 110 Ala Leu Leu Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Asn Val Ile Met Asn Ser Arg Thr Cys Ile Trp Val 130 135 140 Val Ile Val Ser Trp Val Phe Gly Phe Leu Phe Gln Ile Trp Pro Val 145 150 155 160 Tyr Ala Thr Phe Gln Leu Thr Phe Cys Lys Ser Asn Val Val Asn Asn 165 170 175 Phe Phe Cys Asp Arg Gly Gln Leu Leu Lys Leu Ser Cys Asn Asn Thr 180 185 190 Leu Phe Ile Glu Phe Ile Leu Phe Leu Met Ala Val Phe Val Leu Phe 195 200 205 Gly Ser Leu Ile Pro Thr Ile Ile Ser Tyr Thr Tyr Ile Ile Ser Thr 210 215 220 Ile Leu Lys Ile Pro Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu 245 250 255

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Phe Leu Tyr Val Lys Pro Lys Gln Thr Gln 265 Ala Ala Asp Tyr 270 Asn Arg 260 Val Val Ser Leu Met Val Ser Val Val Thr Pro Phe Leu Asn Pro Phe 275 280 285 Ile Phe Thr Leu Arg Asn Asp Lys Val Ile Glu Ala Leu Trp Asp Gly 290 295 300 Met Lys Arg Cys Cys Gln Leu Phe Asn Asn 305 310

<210> 2103 <211> 945 <212> DNA <213> Canis familiaris <400> 2103

atgttgggga atcagtctag tgccactgaa ttttatctcc ttggcttccc tggctccaag 60 gatctacacc atcttctctt tgctaccttc ttcttcttct actcagtgac attaatggga 120 aacatggtca tcatcttgat tgtgtgtgct gataaacgtc tgcagtcccc catgtatttc 180 ttccttagtc acctctctgc cttggagatc ttggttacat ctgttattgt gcctgtgatg 240 ctttgggagt tgctgctccc tgggatgcta acgatatctc tcgctgcatg tgtcacccag 300 ctcttcctgt acctttctct ggggaccacc gagtttgcat tactgggagc aatggctgtg 360 gaccgttacg tggctgtctg taaccctttg aggtataatg tcattatgaa cagccgcacc 420 tgtatctggg tggtcattgt gtcatgggtg tttgggttcc tttttgaaat ctggccagtg 480 tatgccacat ttcagcttac gttctgcaaa tccaatgtgg tgaacaattt cttctgtgac 540 cgagggcaat tgctcaaact atcctgcaac aatactcttt tcatagagtt tattctattc 600 ctaatggctg tctttgttct ttttggttct ctgatcccta caatcatctc ctacacctac 660 atcatctcca ccatcctcaa gatcccctca gcctctgggc ggaggaaagc cttttctacg 720 tgtgcgtctc acttcacctt tgtcgtgatt gggtatggca cctgcttgtt cctctatgtg 780 aaacccaagc aaacccaggc agctgattac aacagagtag catcactgct ggtttcagtg 840 gtgacccctt ttctgaatcc acttatcttt accctccgga atgacaaatt catggaggcc 900

Page 2354

945

069269_0225_SL.TXT tttcgagatg ttgtgaaacg ctgctgtcaa cttctccggg attag <210> 2104 <211> 314 <212> PRT <213> Canis familiaris <400> 2104

Met 1 Leu Gly Asn Gln 5 Ser Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe 10 15 Pro Gly Ser Lys Asp Leu His His Leu Leu Phe Ala Thr Phe Phe Phe 20 25 30 Phe Tyr Ser Val Thr Leu Met Gly Asn Met Val Ile Ile Leu Ile Val 35 40 45 Cys Ala Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ser Ala Leu Glu Ile Leu Val Thr Ser Val Ile Val Pro Val Met 65 70 75 80 Leu Trp Glu Leu Leu Leu Pro Gly Met Leu Thr Ile Ser Leu Ala Ala 85 90 95 Cys Val Thr Gln Leu Phe Leu Tyr Leu Ser Leu Gly Thr Thr Glu Phe 100 105 110 Ala Leu Leu Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Asn Val Ile Met Asn Ser Arg Thr Cys Ile Trp Val 130 135 140 Val Ile Val Ser Trp Val Phe Gly Phe Leu Phe Glu Ile Trp Pro Val 145 150 155 160 Tyr Ala Thr Phe Gln Leu Thr Phe Cys Lys Ser Asn Val Val Asn Asn 165 170 175

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Phe Phe Cys Asp 180 Arg Gly Leu Phe Ile 195 Glu Phe Ile Gly Ser 210 Leu Ile Pro Thr Ile 225 Leu Lys Ile Pro Ser 230 Cys Ala Ser His Phe 245 Thr Phe Leu Tyr Val 260 Lys Pro Val Ala Ser 275 Leu Leu Val Ile Phe 290 Thr Leu Arg Asn Val 305 Lys Arg Cys Cys Gln 310

Gln Leu Leu 185 Lys Leu Leu Phe 200 Leu Met Ala Ile 215 Ile Ser Tyr Thr Ala Ser Gly Arg Arg 235 Phe Val Val Ile 250 Gly Lys Gln Thr 265 Gln Ala Ser Val 280 Val Thr Pro Asp 295 Lys Phe Met Glu Leu Leu Arg Asp

Ser Cys Asn 190 Asn Thr Val Phe 205 Val Leu Phe Tyr 220 Ile Ile Ser Thr Lys Ala Phe Ser Thr 240 Tyr Gly Thr Cys 255 Leu Ala Asp Tyr 270 Asn Arg Phe Leu 285 Asn Pro Leu Ala 300 Phe Arg Asp Val

<210> 2105 <211> 933 <212> DNA <213> Canis familiaris <400> 2105 atgcagcaaa ataacagtac aaaaagaaaa cggtatttgt ttgcttatta ttgtgaccat ttattttatt tgtcccttgc gtggattcac tctctgcaaa tactgagttc atactgttag aatatttttc attttttatt caagtccagc cggacacttg tgattcctgc ttttcaactt aaatatcata acttacaatg gattgaccca agatcctatg tgggaactgt ggttgggaat ggagccccat gtactatttc ccacagcccc caaactaatt aatgcatgac tcaagtcttt

120

180

240

300

Page 2356

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gcactgcatt tctttggttg catggaggtt tttgtcctcc tcctcatggc ctttgaccgg 360 tatgtggcca tctgtaagcc cttacattac acaaccatca tgagccggca ggtctgcacc 420 atcctaattg ttctggcatg gattggatct tttatccatt ctacagccca gattatcctg 480 gctttgagat tgcccttctg tggacccaat ttgattgatc attactgctg tgatttgcag 540 cccttgctga aacttgcttg catggacact tataagatca acctactgtt ggtttctaat 600 agtggggcca tttgttcaag cagttttgtg attctgatga tctcctacat tgtcatcttg 660 cattccctgc gaaaccacag tgcggaaggg aggaaaaaag ctctctctac ttgcatttct 720 cacatcatcg tagtagtctt atgctttggt ccatgtacat tcatttatac acgcccccca 780 accacttacc ccatagacaa gatgatggct gtattttata ctattgggac accttttctc 840 aacccactca tctacacatt gaggaatgca gaagtgaaaa atgccatgag aaagctatgg 900 catatcaaga ttaccactga aagcggaaga tga 933

<210> 2106 <211> 310 <212> PRT <213> Canis familiaris <400> 2106

Met 1 Gln Gln Asn Asn 5 Ser Thr Thr Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Gln Asp Pro Met Lys Lys Lys Thr Val Phe Val Ile Phe Phe Ile Phe 20 25 30 Tyr Leu Gly Thr Val Val Gly Asn Leu Leu Ile Ile Val Thr Ile Lys 35 40 45 Ser Ser Arg Thr Leu Gly Ser Pro Met Tyr Tyr Phe Leu Phe Tyr Leu 50 55 60 Ser Leu Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Lys Leu Ile 65 70 75 80 Val Asp Ser Leu Ser Ala Lys Asn Ile Ile Thr Tyr Asn Glu Cys Met

85 90 95

Page 2357

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Thr Gln Val Phe 100 Ala Leu His Phe Phe Gly Cys Met Glu Val Phe Val 105 110 Leu Leu Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Ser Arg Gln Val Cys Thr Ile Leu Ile Val 130 135 140 Leu Ala Trp Ile Gly Ser Phe Ile His Ser Thr Ala Gln Ile Ile Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Leu Ile Asp His Tyr Cys 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Lys 180 185 190 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Ser Ser Ser 195 200 205 Phe Val Ile Leu Met Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Lys Lys Ala Leu Ser Thr Cys Ile Ser 225 230 235 240 His Ile Ile Val Val Val Leu Cys Phe Gly Pro Cys Thr Phe Ile Tyr 245 250 255 Thr Arg Pro Pro Thr Thr Tyr Pro Ile Asp Lys Met Met Ala Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp His Ile Lys Ile 290 295 300

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Thr Thr Glu Ser Gly Arg 305 310 <210> 2107 <211> 939 <212> DNA <213> Canis familiaris <400> 2107

atgagaaacc acacagaact aacagatttt atcctcctgg gattgtcaga tgacccacag 60 cttcaggagg tgatctttgc ctttctgctt atcacctaca tgctcagcat cactgggaac 120 ctgaccatta tcaccctcac cctgctggat tcccacctcc agacccccat gtatttcttc 180 ctcagaaact tctccttact cgagatttca ttcacaaatg tgagcatacc caagttcctg 240 agcaccctga ttacaggaga taaaactgtt tcctttaatg attgtatggc tcagttattt 300 tttttcattc tgttgggagt cactgaattt tacctgctgg ctgccatgtc ctatgaccga 360 tacattgcca tctgcaaacc tctgcattac atgaccatca tgaatcccag agtctgcata 420 ctccttgtct ttgcttcttg gtcggcttca ttcttaatca tattcccatt actcatgctg 480 ttcatacagc ttgattattg taagtccaat gctatagacc attttacctg tgactatttc 540 cccttactac atctttcttg ttcagacact agattcttag agatagtggg tttttcctgt 600 gctgttttta cgttaatgtt cacattggtg ataataattc tgtcctacat atatatcctc 660 agaacaattt tgaagattcc ttctactagt cagaggacaa aggccttttc cacctgttct 720 tcccacatga ttgtcatctc tatctcctat ggcagctgca ttttcatgta tattaaccca 780 gcagcaaaag acagagtgtc tctgagcaag ggagttgctg tgctaaacac ctcggtagcc 840 cccatgctga acccctttat ttacagccta aggaaccagc aagtcaagcg agccttcctg 900 gacagggcaa ggaagattgt atttttctca agcaaatga 939

<210> 2108 <211> 312 <212> PRT <213> Canis familiaris <400> 2108

Met Arg Asn His Thr Glu Leu Thr Asp Phe Ile Leu Leu Gly Leu Ser Page 2359

0 6926 9_02 25_S L.TX T 1 5 10 15 Asp Asp Pro Gln Leu Gln Glu Val Ile Phe Ala Phe Leu Leu Ile Thr 20 25 30 Tyr Met Leu Ser Ile Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Leu Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Leu Leu Glu Ile Ser Phe Thr Asn Val Ser Ile Pro Lys Phe Leu 65 70 75 80 Ser Thr Leu Ile Thr Gly Asp Lys Thr Val Ser Phe Asn Asp Cys Met 85 90 95 Ala Gln Leu Phe Phe Phe Ile Leu Leu Gly Val Thr Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Ile Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Pro Arg Val Cys Ile Leu Leu Val Phe 130 135 140 Ala Ser Trp Ser Ala Ser Phe Leu Ile Ile Phe Pro Leu Leu Met Leu 145 150 155 160 Phe Ile Gln Leu Asp Tyr Cys Lys Ser Asn Ala Ile Asp His Phe Thr 165 170 175 Cys Asp Tyr Phe Pro Leu Leu His Leu Ser Cys Ser Asp Thr Arg Phe 180 185 190 Leu Glu Ile Val Gly Phe Ser Cys Ala Val Phe Thr Leu Met Phe Thr 195 200 205 Leu Val Ile Ile Ile Leu Ser Tyr Ile Tyr Ile Leu Arg Thr Ile Leu

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210 215 Thr Lys 220 Ala Phe Ser Thr Cys Ser Lys 225 Ile Pro Ser Thr Ser 230 Gln Arg 235 240 Ser His Met Ile Val Ile Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Asn Pro Ala Ala Lys Asp Arg Val Ser Leu Ser Lys Gly Val 260 265 270 Ala Val Leu Asn Thr Ser Val Ala Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Gln Gln Val Lys Arg Ala Phe Leu Asp Arg Ala Arg 290 295 300 Lys Ile Val Phe Phe Ser Ser Lys 305 310

<210> 2109 <211> 966 <212> DNA <213> Canis familiaris <400> 2109

atggccaact tgacctccat gagtggattc ctcctcatgg ggttttctga tcatcgtgag 60 cttcagattt tacatgcatt gctttttttg gtgacatacc tgttggcctt gacaggcaac 120 ctcctcatta tcactgtaac cagcttggac catcacctac agtcccccat gtattacttc 180 ttgaagcacc tctctcttct ggacctctgc ttcatctctg tcacagtccc ccagtccatc 240 acaaattcac ttatgaacaa tggttacatt tcctatgtcc agtgcattct tcaggtgttc 300 ttcttcatag ctctggcctc atcagaagtg gccatcctca cagtgatgtc ttatgaccgc 360 tatgtctcca tctgtcggcc cctgcagtat gagaccatta tgaacccctg catttgtagg 420 tatgcagtga cagctgtgtg gctggctggg ggcctctctg ggctcatgca tacggctgtg 480 aacttctcca tacctctctg tggggagaga gtcattcacc aattcttctg tgatgttcct 540 cagatgctga aactagcttg ttctcatgaa ttcatcaatg agattgcagt ggctgccttc 600

Page 2361

069269_0225_SL.TXT

acaacctcag cagcattcat ctgcttggtc tccatcgtgc tctcctatgt tcatatcttt 660 tctaccgtgc tgaggatccc atcagccgag ggccggacca aagtctttgc cacctgccta 720 ccacacctgt ttgtagtcac cttcttcctc tccactgcag gctttgagtt tctgcagccc 780 ccttctgact cccaatcagc tatggacatc atgttatcca tattctatac ggtgatacca 840 ccaacactca atccagttat atacagttta cggaatgaag ccattaaggc tgctctgaag 900 aaggtgctgt caaaaggaga atttgctcag agaaaaatgt atttaaaaac catttttaaa 960

ttctaa 966 <210> 2110 <211> 321 <212> PRT <213> Canis familiaris

<400> 2110 Ser Met Ser Gly Phe Leu Leu Met Gly Phe Ser Met 1 Ala Asn Leu Thr 5 10 15 Asp His Arg Glu Leu Gln Ile Leu His Ala Leu Leu Phe Leu Val Thr 20 25 30 Tyr Leu Leu Ala Leu Thr Gly Asn Leu Leu Ile Ile Thr Val Thr Ser 35 40 45 Leu Asp His His Leu Gln Ser Pro Met Tyr Tyr Phe Leu Lys His Leu 50 55 60 Ser Leu Leu Asp Leu Cys Phe Ile Ser Val Thr Val Pro Gln Ser Ile 65 70 75 80 Thr Asn Ser Leu Met Asn Asn Gly Tyr Ile Ser Tyr Val Gln Cys Ile 85 90 95 Leu Gln Val Phe Phe Phe Ile Ala Leu Ala Ser Ser Glu Val Ala Ile 100 105 110 Leu Thr Val Met Ser Tyr Asp Arg Tyr Val Ser Ile Cys Arg Pro Leu 115 120 125

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Gln Tyr Glu Thr Ile Met Asn Pro Cys Ile Cys Arg Tyr Ala Val Thr 130 135 140 Ala Val Trp Leu Ala Gly Gly Leu Ser Gly Leu Met His Thr Ala Val 145 150 155 160 Asn Phe Ser Ile Pro Leu Cys Gly Glu Arg Val Ile His Gln Phe Phe 165 170 175 Cys Asp Val Pro Gln Met Leu Lys Leu Ala Cys Ser His Glu Phe Ile 180 185 190 Asn Glu Ile Ala Val Ala Ala Phe Thr Thr Ser Ala Ala Phe Ile Cys 195 200 205 Leu Val Ser Ile Val Leu Ser Tyr Val His Ile Phe Ser Thr Val Leu 210 215 220 Arg Ile Pro Ser Ala Glu Gly Arg Thr Lys Val Phe Ala Thr Cys Leu 225 230 235 240 Pro His Leu Phe Val Val Thr Phe Phe Leu Ser Thr Ala Gly Phe Glu 245 250 255 Phe Leu Gln Pro Pro Ser Asp Ser Gln Ser Ala Met Asp Ile Met Leu 260 265 270 Ser Ile Phe Tyr Thr Val Ile Pro Pro Thr Leu Asn Pro Val Ile Tyr 275 280 285 Ser Leu Arg Asn Glu Ala Ile Lys Ala Ala Leu Lys Lys Val Leu Ser 290 295 300 Lys Gly Glu Phe Ala Gln Arg Lys Met Tyr Leu Lys Thr Ile Phe Lys 305 310 315 320 Phe

Page 2363

069269_0225_SL.TXT <210> 2111 <211> 939 <212> DNA <213> Canis familiaris <400> 2111

atgagaaatc atacagcagt aacaacattc atcctgctag gattgacaga tgacccaaaa 60 atacaagttc tactctttgt atttttgttt ctcacctaca tgttgagtgt aactggaaac 120 ctcatcatta tcaccctcac actggtggac tcccatctta aaactcccat gtattttttc 180 ctccgaaatt tctctttctt agaagtctca ttcaccactg tctgtattcc cagattcctg 240 tatactatga ccactggaga taatactgtt tcctataatg cttgtgccac ccagttattt 300 tttgttgtcc tctttggagc aacagaattt tttctccttg ccgccatgtc ctatgaccgc 360 tatgtggcca tttgcaagcc cctgcattat acaactatca tgaacaacag agtctgcact 420 accctcgttc tctgctgttg gtttgctggc ctgttaatca tcctcccacc tcttggcctg 480 ggcctccagc tggaattctg tgactcaaat gtgattgatc attttggctg tgatgcatct 540 ccaattttac agataacctg ctcagacaca gtcttaatcg agagaattgt tctgagtttt 600 gctgtgctga cactcattat taccttagtg tgtgtagtcc tctcctatac ctacatcatt 660 aagaccattc taagattccc ttctgcccaa caaaggaaaa aggccttttc cacctgctct 720 tcccatatga ttgtggtttc catcacttat ggcagctgca tcttcatcta catcaaacct 780 tcagcaaagg aaggagtagc tattaataaa gtagtgtctg tgctcactac ttcagttgct 840 cctttgttta acccattcat ttatacactt cgaaacaaac aagtgaaaga tgccttcaaa 900 gacacagtaa aatggattgt atttctcaca aagaagtaa 939

<210> 2112 <211> 312 <212> PRT <213> Canis familiaris <400> 2112

Met Arg Asn His Thr Ala Val Thr Thr Phe Ile Leu Leu Gly Leu Thr

1 5 10 15

Asp Asp Pro Lys Ile Gln Val Leu Leu Phe Val Phe Leu Phe Leu Thr

Page 2364

069269_0225_SL.TXT 25 30

Tyr Met Leu 35 Ser Val Thr Gly Asn Leu Ile Ile Ile Thr Leu Thr Leu 40 45 Val Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Leu Glu Val Ser Phe Thr Thr Val Cys Ile Pro Arg Phe Leu 65 70 75 80 Tyr Thr Met Thr Thr Gly Asp Asn Thr Val Ser Tyr Asn Ala Cys Ala 85 90 95 Thr Gln Leu Phe Phe Val Val Leu Phe Gly Ala Thr Glu Phe Phe Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Asn Asn Arg Val Cys Thr Thr Leu Val Leu 130 135 140 Cys Cys Trp Phe Ala Gly Leu Leu Ile Ile Leu Pro Pro Leu Gly Leu 145 150 155 160 Gly Leu Gln Leu Glu Phe Cys Asp Ser Asn Val Ile Asp His Phe Gly 165 170 175 Cys Asp Ala Ser Pro Ile Leu Gln Ile Thr Cys Ser Asp Thr Val Leu 180 185 190 Ile Glu Arg Ile Val Leu Ser Phe Ala Val Leu Thr Leu Ile Ile Thr 195 200 205 Leu Val Cys Val Val Leu Ser Tyr Thr Tyr Ile Ile Lys Thr Ile Leu 210 215 220 Arg Phe Pro Ser Ala Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser

Page 2365

069269_0225_SL.TXT

225 230 Val Val Ser Ile Thr Tyr 235 240 Ser His Met Ile Gly Ser Cys Ile Phe 255 Ile 245 250 Tyr Ile Lys Pro Ser Ala Lys Glu Gly Val Ala Ile Asn Lys Val Val 260 265 270 Ser Val Leu Thr Thr Ser Val Ala Pro Leu Phe Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Lys Asp Ala Phe Lys Asp Thr Val Lys 290 295 300 Trp Ile Val Phe Leu Thr Lys Lys 305 310

<210> 2113 <211> 966 <212> DNA <213> Canis familiaris <400> 2113

atgagaaatc atacagtagt aacaacattc atcctgctag gattgacaga tgacccaaaa 60 atacaagttc tgctctttgt atttttgttt ctcacctaca tgttgagtgt aactggaaac 120 ctcatcatta tcaccctcac actggtggac tccaatctta aaactcccat gtattttttc 180 ctctgaaatt tctctttctt agaagtctca ttcaccactg tctgtattcc cagattcctg 240 tatactatga ccactggaga taatactgtt tcctataatg cttgtgccac ccagttattc 300 tttgttgtct tctttggagc aacagaattt tttctccttg ccgccatgtc ctatgaccgc 360 tatgtggcca tttgcaagcc cctgcattat acaactatca tgaacaacag agtctgcact 420 accctcgttc tctgctgttg gtttgctggc ccgttaatca tcctcccgcc tcttggcctg 480 ggcctccagc tggaattctg tgactcaaat gtgattgatc attttggctg tgatgcatct 540 ccaattttac agataacctg ctcagacaca gtcttaatag agagaattgt tctgagtttt 600 gccatactga cactcattat taccttagtg tgtgtagtct tctcctatac ctacatcatt 660 aagaccattc taagattccc ttctgcccaa caaaggaaaa aggccttttc cacctgctct 720

Page 2366

069269_0225_SL.TXT tcccatatga ttgtggtttc catcacttat ggcagctgca tcttcatcta catcaaacct tcagcaaagg aaggagtagc tattaataaa gtagtgtctg tgctcactac ttcagttgct cctttgttta acccattcat ttatacgctt tgaaacaaac aagtgaaaga tgccttcaaa gacacagtaa aaaaataaaa taaaaaaaaa gacacagtaa aatggattgt atttctcaca aagaag <210> 2114 <211> 61 <212> PRT <213> Canis familiaris

<400> 2114 Met 1 Arg Asn His Thr Val Val Thr Thr Phe Ile Leu Leu Gly Leu Thr 5 10 15 Asp Asp Pro Lys Ile Gln Val Leu Leu Phe Val Phe Leu Phe Leu Thr 20 25 30 Tyr Met Leu Ser Val Thr Gly Asn Leu Ile Ile Ile Thr Leu Thr Leu 35 40 45 Val Asp Ser Asn Leu Lys Thr Pro Met Tyr Phe Phe Leu 50 55 60

<210> 2115 <211> 267 <212> DNA <213> Canis familiaris <400> 2115 atgtcaatga atagcagcgt gaatgaattc attctgcttg gcttgacaca ggatccaaga aaacagaaag caatatttgg ggtcttctta atgctttacc ttgccacact gttgggaaac tttctcattg tagtgactat taaaagaagc aggactcttg ggagtcccat gtacttcttc ctattttacc tgtcctttgc tgatgcctgc ttctctacaa ccatagcccc cagattgatt gtggatgcca tttcccagca gaagacc

780

840

900

960

966

120

180

240

267 <210> 2116

Page 2367

069269_0225_SL.TXT <211> 89 <212> PRT <213> Canis familiaris

<400> 2116 Ser Ser 5 Val Asn Glu Phe Ile Leu Leu Gly Leu Thr Met Ser 1 Met Asn 10 15 Gln Asp Pro Arg Lys Gln Lys Ala Ile Phe Gly Val Phe Leu Met Leu 20 25 30 Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45 Arg Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Ala Asp Ala Cys Phe Ser Thr Thr Ile Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Ile Ser Gln Gln Lys Thr 85

<210> 2117 <211> 873 <212> DNA <213> Canis familiaris <400> 2117

ttcttgatcc tacttggaat cccaggactg gagaattacc aattttggat tgcctttcct 60 ctatgtgcca tgtatttcgt agctatagtt ggcaatatca ttatccttca tataatctga 120 actgaccaca ccctgcttga gcccatgtac ctttttctag ccatgctggc tatcactgac 180 ctggctctat cctcttccac gcaacctaaa atgctggcta tactctggtt tcgtgctcat 240 gaattgcatc catgcctttt cctctgtgaa gtccaggttg ttcatggcta tggccttgga 300 caattatgtg gctatctgtt tcccactcca ccactctact ttcctgaccc cagctgagtg 360 ggtaaactgg gagtagctgt gatgatgaga ggattgctat gggtgagccc cttctgcatt 420 atggtctcca ggatgccctt ctgccccaaa cacatcattg tccagtcata ctgtgagcac 480 atggctgtgt taaagctggt gtgtgcagac actagagtaa accgtgccta tgggctcttt 540

Page 2368

069269_0225_SL.TXT ccggctttct cggtggttgg ctttgatata attgtcatca gtacatccca tgtgatgatt ctgagaactg ttctggggtt gccctctgat gaagcccggt tcaaggtttt tggcacatgt gcttccctta tctgtatcat cttggctttt tatatcccag ccctctttac tttcctcact caccgctttg gacaccatgt gcctcaagtg gtacatatca tgtttaccaa tttctatctc ctggtacctc ccatgctcaa ccccatcatc tatggagtca gtaccaagca gatcagggac agggatattc aaggttgttg tggaaaagat ccc

600

660

720

780

840

873 <210> 2118 <211> 164 <212> PRT <213> Canis familiaris <400> 2118

Met Met Arg Gly Leu Leu Trp Val Ser Pro Phe Cys Ile Met Val Ser 1 5 10 15 Arg Met Pro Phe Cys Pro Lys His Ile Ile Val Gln Ser Tyr Cys Glu 20 25 30 His Met Ala Val Leu Lys Leu Val Cys Ala Asp Thr Arg Val Asn Arg 35 40 45 Ala Tyr Gly Leu Phe Pro Ala Phe Ser Val Val Gly Phe Asp Ile Ile 50 55 60 Val Ile Ser Thr Ser His Val Met Ile Leu Arg Thr Val Leu Gly Leu 65 70 75 80 Pro Ser Asp Glu Ala Arg Phe Lys Val Phe Gly Thr Cys Ala Ser Leu 85 90 95 Ile Cys Ile Ile Leu Ala Phe Tyr Ile Pro Ala Leu Phe Thr Phe Leu 100 105 110 Thr His Arg Phe Gly His His Val Pro Gln Val Val His Ile Met Phe 115 120 125

Page 2369

069269_0225_SL.TXT

Thr Asn Phe Tyr Leu Leu Val Pro Pro Met Leu Asn Pro Ile Ile Tyr 130 135 140 Gly Val Ser Thr Lys Gln Ile Arg Asp Arg Asp Ile Gln Gly Cys Cys 145 150 155 160 Gly Lys Asp Pro

<210> 2119 <211> 930 <212> DNA <213> Canis familiaris <400> 2119

atgactgagg ataattactc cttgacaact gaatttattc tcataggatt tacagatcac 60 ccaaagttga agaccattct gtttgtggtg tttctcacta tctatctggt gaccatggtg 120 gggaatctgg gcctggtggc attgatcctt atggagcgtt gccttcacac acccatgtac 180 atctttctgg gcaacctggc tctaatggat tcctgttgtg cctgtgccat tactcccaag 240 atgttagaga atttcttttc gaaggacaga atgatttccc tctatgaatg catggcacaa 300 ttttattttc tctgtcttgc tgaaactaca gattgctttc tcctggcagc aatggcctat 360 gaccgctatg tggccatctg cagcccactg cagtaccaca ccctgatgtc gaagaagctc 420 tgccttcaga tgaccgcagg ggcctacata gcaggaaacc tgcattccat aattcatata 480 gtgtttctct ttcggttaac tttctgtagg tctcatcaga ttaatcactt tttttgtgaa 540 tttcttccat tattcaaact ctcctgtgtt gacccttata tcaatgaatt gttgatgttt 600 atctttccag gttcagttct agtgttctct attatcatag tcataatctc ttatctctgc 660 atccttttca tgattttcaa aatgaaatcc aaagagggaa gaggcagagc cttatctact 720 tgtgcatctc actttctctc tgtctcaatg ttctatggtt ctcttctctt tgtgtacgtt 780 cgaccaaatt cagttaaaga agaggataaa gatatatctg ttgctatttt ttatactcta 840 gtaatccctt tattaaaccc ttttatttat agtctacgaa ataaggaagt aataaatgct 900 atgaaaaaaa acataaggaa aaatttttga 930

<210> 2120

Page 2370

069269_0225_SL.TXT <211> 309 <212> PRT <213> Canis familiaris

<400> 2120 Ile 15 Gly Met 1 Thr Glu Asp Asn Tyr Ser Leu 5 Thr Thr 10 Glu Phe Ile Leu Phe Thr Asp His Pro Lys Leu Lys Thr Ile Leu Phe Val Val Phe Leu 20 25 30 Thr Ile Tyr Leu Val Thr Met Val Gly Asn Leu Gly Leu Val Ala Leu 35 40 45 Ile Leu Met Glu Arg Cys Leu His Thr Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ala Leu Met Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Glu Asn Phe Phe Ser Lys Asp Arg Met Ile Ser Leu Tyr Glu 85 90 95 Cys Met Ala Gln Phe Tyr Phe Leu Cys Leu Ala Glu Thr Thr Asp Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Gln Tyr His Thr Leu Met Ser Lys Lys Leu Cys Leu Gln Met 130 135 140 Thr Ala Gly Ala Tyr Ile Ala Gly Asn Leu His Ser Ile Ile His Ile 145 150 155 160 Val Phe Leu Phe Arg Leu Thr Phe Cys Arg Ser His Gln Ile Asn His 165 170 175 Phe Phe Cys Glu Phe Leu Pro Leu Phe Lys Leu Ser Cys Val Asp Pro 180 185 190

Page 2371

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Tyr Ile Asn Glu Leu Leu Met Phe Ile Phe Pro Gly Ser Val Leu Val 195 200 205 Phe Ser Ile Ile Ile Val Ile Ile Ser Tyr Leu Cys Ile Leu Phe Met 210 215 220 Ile Phe Lys Met Lys Ser Lys Glu Gly Arg Gly Arg Ala Leu Ser Thr 225 230 235 240 Cys Ala Ser His Phe Leu Ser Val Ser Met Phe Tyr Gly Ser Leu Leu 245 250 255 Phe Val Tyr Val Arg Pro Asn Ser Val Lys Glu Glu Asp Lys Asp Ile 260 265 270 Ser Val Ala Ile Phe Tyr Thr Leu Val Ile Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Asn Ala Met Lys Lys Asn 290 295 300 Ile Arg Lys Asn Phe

305 <210> 2121 <211> 939 <212> DNA <213> Canis familiaris <400> 2121 atgagaaacc acacagaact aacagacttt atcctcctgg gattgtcaga tgacccacag cttcaggagg tgatctttgt ctttctgctt atcacctaca tgctcagcat cactgggaac ctgaccatta tcaccctcac cctgctggat tcccacctcc agacccccat gtatttcttc ctcagaaact tctccttact tgagatttca ttcacaactg tgagcatacc caagttcctg agcaccctga ttacaggaga taaaactgtt tcctttaatg attgtatggc tcagttattt tttttcattc tgttgggagt cactgaattt tacctgctgg ctgccatgtc ctatgaccga tacattgcca tctgcaaacc tctgcattac atgaccatca tgaatcccag agtctgcata

120

180

240

300

360

420

Page 2372

069269_0225_SL.TXT

ctccttgtct ttgcttcttg gtcggcttca ttcttaatca tattcccatc actcatgctg 480 ttaatacagc ttgattattg taagtccaat gctatagacc attttacctg tgactatttc 540 cccttactac atctttcttg ttcagacact agattcttag agatagtggg tttttcctgt 600 gctgttttta cgttaatgtt cacattgatg ataataattc tgtcctacat atatatcctc 660 agaacaattt tgaagattcc ttctactagt cagaggacaa aggccttttc cacctgttct 720 tcccacatga ttgtcatctc tatctcctat ggcagctgca ttttcatgta tattaaccca 780 gcagcaaaag acagagtgtc tctgagcaag ggagttgctg tgctaaacac ctcggtagcc 840 cccatgctga acccctttat ttacagccta aggaaccagc aagtcaagca agccttactg 900 gacagggcaa ggaagattgt atttttctca agcaaatga 939

<210> 2122 <211> 312 <212> PRT <213> Canis familiaris

<400> 2122 Glu Leu Thr Asp Phe Ile Leu Leu Gly Leu Ser Met Arg 1 Asn His Thr 5 10 15 Asp Asp Pro Gln Leu Gln Glu Val Ile Phe Val Phe Leu Leu Ile Thr 20 25 30 Tyr Met Leu Ser Ile Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Leu Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Leu Leu Glu Ile Ser Phe Thr Thr Val Ser Ile Pro Lys Phe Leu 65 70 75 80 Ser Thr Leu Ile Thr Gly Asp Lys Thr Val Ser Phe Asn Asp Cys Met 85 90 95 Ala Gln Leu Phe Phe Phe Ile Leu Leu Gly Val Thr Glu Phe Tyr Leu 100 105 110

Page 2373

069269_0225_SL.TXT

Leu Ala Ala Met 115 Ser Tyr Asp Arg Tyr Ile Ala Ile Cys Lys Pro Leu 120 125 His Tyr Met Thr Ile Met Asn Pro Arg Val Cys Ile Leu Leu Val Phe 130 135 140 Ala Ser Trp Ser Ala Ser Phe Leu Ile Ile Phe Pro Ser Leu Met Leu 145 150 155 160 Leu Ile Gln Leu Asp Tyr Cys Lys Ser Asn Ala Ile Asp His Phe Thr 165 170 175 Cys Asp Tyr Phe Pro Leu Leu His Leu Ser Cys Ser Asp Thr Arg Phe 180 185 190 Leu Glu Ile Val Gly Phe Ser Cys Ala Val Phe Thr Leu Met Phe Thr 195 200 205 Leu Met Ile Ile Ile Leu Ser Tyr Ile Tyr Ile Leu Arg Thr Ile Leu 210 215 220 Lys Ile Pro Ser Thr Ser Gln Arg Thr Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Ile Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Asn Pro Ala Ala Lys Asp Arg Val Ser Leu Ser Lys Gly Val 260 265 270 Ala Val Leu Asn Thr Ser Val Ala Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Gln Gln Val Lys Gln Ala Leu Leu Asp Arg Ala Arg 290 295 300 Lys Ile Val Phe Phe Ser Ser Lys 305 310

Page 2374

069269_0225_SL.TXT <210> 2123 <211> 924 <212> DNA <213> Canis familiaris <400> 2123

atggagaatc caaaaaatgt gactgaattc atacatttgg gcattacaga gaacccagag 60 ctgcggaaaa tgctctctgc tgtgtttcta atcatgtatg tgttcacggt tttgggaaac 120 ctagtaattg tggtaactgt gatcacaagt caaagtctga gatcacctat gtattttttc 180 cttactttct tatccttttt ggatgttacc tactcttctg tcattgcccc caagatgatt 240 gtggactccc tctccaagag cactgtcacc tccttaaaag gttgcatggc gcagctcctt 300 gcagagcatt tctttggtgg tgtggggatc atcctcctca tcgtgatggc ctatgaccgc 360 tacgtggcca tctgtaagcc cctgcactac tcgaccatca tgagccctca gatgtgctgc 420 ctgctgctgg gaggggcctg ggtgggggga tttatccatg cagcaataca gcttctcttc 480 atgtatcaaa tacccttctg tggccccaat gtcattgatc attttatatg cgatttgttt 540 cccttgttga aactggcctg catggacacc cataccctgg gtctcctagt catcctcaac 600 agtggggtga tgtgtatgac catcttcctt attctcattg cctcctacgt ggtcatcctc 660 tgctctctga agtcttgcag ctctgaaggg tggcgcaaag ccatctccac ctgtggctcc 720 cacctcaccg tggttgtctt gttctttgtg ccatgcattt tcctgtacgt gcggcctgtg 780 gccacctacc ccattgacaa ggcaatggct gtgtctgatt ccatcatcac acccatgtta 840 aatcctttga tctacaccct gaggaattca gaggtgataa atgccatgag gaaactgggg 900 aaacaaagga gttttgttgg caag 924

<210> 2124 <211> 308 <212> PRT <213> Canis familiaris

<400> 2124 Met Glu Asn Pro Lys Asn Val Thr Glu Phe Ile His Leu Gly Ile Thr 1 5 10 15 Glu Asn Pro Glu Leu Arg Lys Met Leu Ser Ala Val Phe Leu Ile Met Page 2375

069269_0225_SL.TXT 25 30

Tyr Val Phe 35 Thr Val Leu Gly Asn Leu Val Ile Val Val Thr Val Ile 40 45 Thr Ser Gln Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Thr Phe Leu 50 55 60 Ser Phe Leu Asp Val Thr Tyr Ser Ser Val Ile Ala Pro Lys Met Ile 65 70 75 80 Val Asp Ser Leu Ser Lys Ser Thr Val Thr Ser Leu Lys Gly Cys Met 85 90 95 Ala Gln Leu Leu Ala Glu His Phe Phe Gly Gly Val Gly Ile Ile Leu 100 105 110 Leu Ile Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Ser Thr Ile Met Ser Pro Gln Met Cys Cys Leu Leu Leu Gly 130 135 140 Gly Ala Trp Val Gly Gly Phe Ile His Ala Ala Ile Gln Leu Leu Phe 145 150 155 160 Met Tyr Gln Ile Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Ile 165 170 175 Cys Asp Leu Phe Pro Leu Leu Lys Leu Ala Cys Met Asp Thr His Thr 180 185 190 Leu Gly Leu Leu Val Ile Leu Asn Ser Gly Val Met Cys Met Thr Ile 195 200 205 Phe Leu Ile Leu Ile Ala Ser Tyr Val Val Ile Leu Cys Ser Leu Lys 210 215 220 Ser Cys Ser Ser Glu Gly Trp Arg Lys Ala Ile Ser Thr Cys Gly Ser

Page 2376

240

225

230

069269_0225_SL.TXT

235

His Leu Thr Val Val 245 Val Leu Phe Phe Val Pro Cys Ile Phe 250 Leu 255 Tyr Val Arg Pro Val Ala Thr Tyr Pro Ile Asp Lys Ala Met Ala Val Ser 260 265 270 Asp Ser Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Val Ile Asn Ala Met Arg Lys Leu Gly Lys Gln Arg Ser 290 295 300

Phe Val Gly Lys 305 <210> 2125 <211> 933 <212> DNA <213> Canis familiaris <400> 2125 atgaaaaatc attctgcaat aacattcatc ctactaggat taacagatga tccacgatta 60 caggtttttc tttcattatt tctgtttttc acctacattt tcactgttgc tggaaatcta 120 atcattatcc tcctcactct tgtagactct cacctcaaaa cacccatgta ctttttcctt 180 cggaattttt ccatcttaga aataatattt acaactgtct gtgttcctcg attcttatac 240 agcctgacaa ctggggacaa aagtattacc tataatgttt gtgtcatcca attatttttt 300 gttatcctca ttggagcaac agaatttttt cttctaaccg ccatgtgcta tgactgctat 360 gtcgccatct gcaagccctt gcactacact atcatcatga atgaaagggt atgcacaatt 420 cttgtccttt gctgttggct gattgggtta attgtcatac tcccaccact tagcctggga 480 gttcagctag atttctgtaa ctccaatctc attgaccatt ttggttgtga tgcatctcct 540 ctcctgaaga ttgtatgctc agacactcaa tttgtagagc aacttgtttt aatcatggct 600 gtgttgatga tcatagtcac attagtctgt gtatttgtgt catacacata tattgttaag 660 accattttaa gactcccttc agctcagcaa aggaaaaagc ctttctccac ttgttcttcc 720

Page 2377

069269_0225_SL.TXT catatgattg tagtttctat cacctatgga agttgcatat tcatctatat caaacctgca aaggaaggag tggctcttaa taaggtagtg tcattgctca atacctcaat catccctttg ataaaccctt tcatttatac actatggaat aagcaagtca aacaagcctt taaggactca attaaaaaga tggcatttct ttcaaaggat tag

780

840

900

933 <210> 2126 <211> 310 <212> PRT <213> Canis familiaris <400> 2126

Met 1 Lys Asn His Ser Ala Ile Thr Phe Ile Leu Leu Gly Leu Thr Asp 5 10 15 Asp Pro Arg Leu Gln Val Phe Leu Ser Leu Phe Leu Phe Phe Thr Tyr 20 25 30 Ile Phe Thr Val Ala Gly Asn Leu Ile Ile Ile Leu Leu Thr Leu Val 35 40 45 Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe Ser 50 55 60 Ile Leu Glu Ile Ile Phe Thr Thr Val Cys Val Pro Arg Phe Leu Tyr 65 70 75 80 Ser Leu Thr Thr Gly Asp Lys Ser Ile Thr Tyr Asn Val Cys Val Ile 85 90 95 Gln Leu Phe Phe Val Ile Leu Ile Gly Ala Thr Glu Phe Phe Leu Leu 100 105 110 Thr Ala Met Cys Tyr Asp Cys Tyr Val Ala Ile Cys Lys Pro Leu His 115 120 125 Tyr Thr Ile Ile Met Asn Glu Arg Val Cys Thr Ile Leu Val Leu Cys 130 135 140

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Cys 145 Trp Leu Ile Gly Leu 150 Ile Val Val Gln Leu Asp Phe 165 Cys Asn Ser Asp Ala Ser Pro 180 Leu Leu Lys Ile Glu Gln Leu 195 Val Leu Ile Met Ala 200 Val Cys 210 Val Phe Val Ser Tyr 215 Thr Leu 225 Pro Ser Ala Gln Gln 230 Arg Lys His Met Ile Val Val 245 Ser Ile Thr Ile Lys Pro Ala 260 Lys Glu Gly Val Leu Asn Thr 275 Ser Ile Ile Pro Leu 280 Trp Asn 290 Lys Gln Val Lys Gln 295 Ala Ala 305 Phe Leu Ser Lys Asp 310

Ile Leu Pro 155 Pro Leu Ser Leu Gly 160 Asn Leu 170 Ile Asp His Phe Gly 175 Cys Val 185 Cys Ser Asp Thr Gln 190 Phe Val Val Leu Met Ile Ile 205 Val Thr Leu Tyr Ile Val Lys 220 Thr Ile Leu Arg Lys Pro Phe 235 Ser Thr Cys Ser Ser 240 Tyr Gly 250 Ser Cys Ile Phe Ile 255 Tyr Ala 265 Leu Asn Lys Val Val 270 Ser Leu Ile Asn Pro Phe Ile 285 Tyr Thr Leu Phe Lys Asp Ser 300 Ile Lys Lys Met

<210> 2127 <211> 930 <212> DNA <213> Canis familiaris <400> 2127 atgaagttgc agaattattc cttggtgtca gaatttgtgt tgtatggact ctgcatgtca

Page 2379

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tgacatctcc agcatttatt cttcatgttt ttctctggga tctatgtggc cagtgtgctg 120 ggtaacctca tcatggtggt caccgtaatt tctgactcac acttgcactc ctctcctatg 180 tacttcctgc taggaaacct atctttctta gacatatggc tcgcctcctt tgccaccccc 240 aagatgctca gggactttct tagtgaccga aagcttatct cctttggagg atgtatggct 300 caaatcttct tcttgcactt tattggcagg gctgagatgg tacttctggt ttccatggcc 360 tatgacagat acgtggctat atgtaaacct ctgcattata tgaccgtgat gagacggcag 420 acctgcgtgg ggctggtgtt ggtctcatgg gtcactggct ttgtgcattc catcagtcaa 480 gtagccttta ctgtgaattt accgtactgt ggccccaatg aggtggacag cttcttttgt 540 gacctgcctc ctgtgatcaa gcttgcctgc atggacacct acatcttagg tatccttatg 600 atctcagata gtggattact ctctatgagc tgctttctgc tcctcttggt ctcttacact 660 gtcatcctca tcactgtctg acagcgcact gctggtggca tatccaaagc actctccact 720 tgctgtgcac acatcatggt tgtcacactc ttctttgggc cctgcatttt cattgatgtg 780 tggcctttca gccagttctc tgtggacaag ctcctgtctg tgttttacac catttttact 840 ccactcttga acccccttat ctacacactg agaaataaag agatgaaaat agctatgaag 900 aaactgtgta accaccatgt gacttctcgt 930

<210> 2128 <211> 104 <212> PRT <213> Canis familiaris <400> 2128

Thr Arg Ser His Met Val Val Thr Gln Phe Leu His Ser Tyr Phe His 1 5 10 15 Leu Phe Ile Ser Gln Cys Val Asp Lys Gly Val Gln Glu Trp Ser Lys 20 25 30 Asn Gly Val Lys His Arg Gln Glu Leu Val His Arg Glu Leu Ala Glu 35 40 45 Arg Pro His Ile Asn Glu Asn Ala Gly Pro Lys Glu Glu Cys Asp Asn 50 55 60

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His Asp Val Cys Thr Ala Ser Gly Glu Cys Phe Gly Tyr Ala Thr Ser 65 70 75 80 Ser Ala Leu Ser Asp Ser Asp Glu Asp Asp Ser Val Arg Asp Gln Glu 85 90 95 Glu Gln Lys Ala Ala His Arg Glu 100

<210> 2129 <211> 762 <212> DNA <213> Canis familiaris <400> 2129 atgtatgaat caaattattc tgatgtgttt tggtttatat ccttggcact ttctacctat 60 agaccagcac tgaattttct ccttgccttt tcttcagtgt tttatgtaac agttatcctg 120 ggaaacctcc ttgttgtgtt tagagtgatg tttaccctta cttacattcc actatgtact 180 tccttttagc aaatctctca ttcattgact tgtgtctttc caccttaatg attcctaaga 240 agattcatga cctgcactca gggcacaaaa ccatatcctt ccagggatgt gtcatccatt 300 tatttgtatt tcatgtcctg ggtggatctg agatggtgct gctcattgcc atcttggatg 360 gtcttggatc gctatgtggc catatgtaag cctctccact atctgactat catgagcccg 420 cagatgtgaa ttttgcttct gtctggtgct tgggctgttg gcctcattca ttcagtggcc 480 cagttagctt tcgttgtcca cttgactttt tgtggtccta atgagataga cagctttgct 540 tttgctttga aacttccttg gttcatcaaa cgtgtctgcg cagaccctta caggatggaa 600 ttcatggtga ctgccaacag caggttcatt tccatgggcg ccttcttctc attgcttatc 660 tcctaagttt tcatcctggt cactctctgg aaacgttcct caggtggttt gtctaaggcc 720 ttttctactc tgtcagtgca cattaaagaa gctgtggtct at 762 <210> 2130 <211> 62 <212> PRT <213> Canis familiaris <400> 2130

Page 2381

Met 1 Tyr Glu Ser Asn 5 Tyr Ser 069269_0225_SL.TXT Asp Val Phe Trp Phe Ile 10 Ser Leu 15 Ala Leu Ser Thr Tyr Arg Pro Ala Leu Asn Phe Leu Leu Ala Phe Ser Ser 20 25 30 Val Phe Tyr Val Thr Val Ile Leu Gly Asn Leu Leu Val Val Phe Arg 35 40 45 Val Met Phe Thr Leu Thr Tyr Ile Pro Leu Cys Thr Ser Phe 50 55 60

<210> 2131 <211> 1032 <212> DNA <213> Canis familiaris <400> 2131

atgaacaata ctataaggct atctgtaata tggaaatctg ttatttttgc agctttaaaa 60 aaaaaagaat attccaacgt aaataattgt tctagctctg tgagtgaatt catccttttg 120 ggcttccctt atacctggga aattcagatt ctccttttct caatcttctg tggaacttat 180 attctgacac tgactggaaa tctgtgcatt atctgtgctg tgaggtggga ccatcgccta 240 caaactccaa tgtacatcct gctggccaat ttctccttcc tggagatctg ctttatcacc 300 tccactgtcc ccaaaatgct agccaacttg ctgtctgaga ccagaaccat ctgcttctat 360 ggctgcttcc tccagttcta cttcttcttc tccgagggca ccgctgagac cttattcttg 420 tctgccatgg cctttgacag gtttcttgct atctgcaggc ccctgcacta ccccactgtc 480 atgactgctc agcgctgcat cagaatagga gctgggtgct gggtgtgtgg cttcttatac 540 ttcctcttgc ctatttacct catctctcag ctcccatttt gttgttctaa taagattgat 600 cacttcctgt gtgacccagg acctcttatg aagctgtcct gtgtgccagc tcctgctact 660 gagatcatct gtgccatcta taactcagtc ctcattttct ccaccttatt cttcattacc 720 agctcctata ccttggtgat cagagctgtg ctcagggtcc cctcagcaga aggtcggcat 780 aaggccttct ccacgtgtgg ctcccatctg gctgtggtgt ccctgtttta tggctctatc 840 atggttgtat atgtaagccc cacagcagga aatccagcag ggatccaaaa atatgtgact 900

Page 2382

069269_0225_SL.TXT ttgttctatt ctgtgttaac tccacttttc aaccctttga tctatagtct tcgaaataaa gaaatgaagg aagctctgag aaagatattt agaattgtaa gatttagtca aaggcatgaa agaaatattt ga

960

1020

1032 <210> 2132 <211> 343 <212> PRT <213> Canis familiaris

<400> 2132 Arg Leu Ser Val Ile Trp Lys Ser Val Ile Phe Met Asn 1 Asn Thr Ile 5 10 15 Ala Ala Leu Lys Lys Lys Glu Tyr Ser Asn Val Asn Asn Cys Ser Ser 20 25 30 Ser Val Ser Glu Phe Ile Leu Leu Gly Phe Pro Tyr Thr Trp Glu Ile 35 40 45 Gln Ile Leu Leu Phe Ser Ile Phe Cys Gly Thr Tyr Ile Leu Thr Leu 50 55 60 Thr Gly Asn Leu Cys Ile Ile Cys Ala Val Arg Trp Asp His Arg Leu 65 70 75 80 Gln Thr Pro Met Tyr Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile 85 90 95 Cys Phe Ile Thr Ser Thr Val Pro Lys Met Leu Ala Asn Leu Leu Ser 100 105 110 Glu Thr Arg Thr Ile Cys Phe Tyr Gly Cys Phe Leu Gln Phe Tyr Phe 115 120 125 Phe Phe Ser Glu Gly Thr Ala Glu Thr Leu Phe Leu Ser Ala Met Ala 130 135 140 Phe Asp Arg Phe Leu Ala Ile Cys Arg Pro Leu His Tyr Pro Thr Val 145 150 155 160

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Met Thr Ala Gln Arg Cys Ile Arg Ile Gly Ala Gly Cys Trp Val Cys 165 170 175 Gly Phe Leu Tyr Phe Leu Leu Pro Ile Tyr Leu Ile Ser Gln Leu Pro 180 185 190 Phe Cys Cys Ser Asn Lys Ile Asp His Phe Leu Cys Asp Pro Gly Pro 195 200 205 Leu Met Lys Leu Ser Cys Val Pro Ala Pro Ala Thr Glu Ile Ile Cys 210 215 220 Ala Ile Tyr Asn Ser Val Leu Ile Phe Ser Thr Leu Phe Phe Ile Thr 225 230 235 240 Ser Ser Tyr Thr Leu Val Ile Arg Ala Val Leu Arg Val Pro Ser Ala 245 250 255 Glu Gly Arg His Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val 260 265 270 Val Ser Leu Phe Tyr Gly Ser Ile Met Val Val Tyr Val Ser Pro Thr 275 280 285 Ala Gly Asn Pro Ala Gly Ile Gln Lys Tyr Val Thr Leu Phe Tyr Ser 290 295 300 Val Leu Thr Pro Leu Phe Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys 305 310 315 320 Glu Met Lys Glu Ala Leu Arg Lys Ile Phe Arg Ile Val Arg Phe Ser 325 330 335 Gln Arg His Glu Arg Asn Ile

<210> 2133 <211> 972 <212> DNA

340

Page 2384

069269_0225_SL.TXT <213> Canis familiaris <400> 2133

atggttagat ttcaaaagtc agtgatgaga aactatacag caataacaac ttttatcctg 60 ttgggactga cagacgaccc acaactgcaa atcctgctct ttatctttct atttctcacc 120 tacatcttga gcgtaacagg gaacctgact attatcaccc tcacactggt gaactcccat 180 cttaaaactc ctatgtactt ttttctgaga aatttctcct tcttagaagt gtcattcacc 240 actgtctgca ttcctagatt cctgtatagt atatcaacag gggacaatac tattacctac 300 aatgcttgtg caagtcaaat attttttgtt attctctttg gagcaactga attttttctc 360 ctggcagcca tgtcctatga tcgctatgtt gctatctgta aaccacttca ttacatgacc 420 atcatgagca atagggtgtg tagcttatta gtcttctgct gttgggtgtc tggcttgatg 480 atcattctcc caccccttag cttgggcctc cagctggaat tctgtgactc caatgccatt 540 gatcatttta gctgtgatgc aggtcccctc ctgaagatct catgttcaga tacatggatg 600 atagagcaaa tggttattct tgtggctgta tttgcactca ttatcacctt agtgtgtgta 660 tttctgtcct acacatacat catcaggacg attctgagat tcccctctgt ccaacaaaga 720 aaaaaggcct tttccacctg ctcatcccac atgattgtag tttccatcac ctatggaagc 780 tgcatcttca tctatgtcaa gccatcagca aaagaagaga tagccataaa taaaggtgtt 840 tcggtgctca ctacttctgt tgcacccttg ttgaacccct tcatttacac cttgagaaat 900 aagcaagtga aacaagcttt taatgacttc ataaagaaga tgacatttca ctcaatgaaa 960 ctgaagtttt ga 972

<210> 2134 <211> 323 <212> PRT <213> Canis familiaris <400> 2134

Met Val Arg Phe Gln Lys Ser Val Met Arg Asn Tyr Thr Ala Ile Thr 1 5 10 15 Thr Phe Ile Leu Leu Gly Leu Thr Asp Asp Pro Gln Leu Gln Ile Leu

20 25 30

Page 2385

Leu Phe Ile 35 Phe Leu Phe Leu 069269_0225_SL.TXT Thr Tyr Ile Leu Ser Val 40 45 Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu Val Asn Ser His Leu Lys Thr Pro 50 55 60 Met Tyr Phe Phe Leu Arg Asn Phe Ser Phe Leu Glu Val Ser Phe Thr 65 70 75 80 Thr Val Cys Ile Pro Arg Phe Leu Tyr Ser Ile Ser Thr Gly Asp Asn 85 90 95 Thr Ile Thr Tyr Asn Ala Cys Ala Ser Gln Ile Phe Phe Val Ile Leu 100 105 110 Phe Gly Ala Thr Glu Phe Phe Leu Leu Ala Ala Met Ser Tyr Asp Arg 115 120 125 Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Ile Met Ser Asn 130 135 140 Arg Val Cys Ser Leu Leu Val Phe Cys Cys Trp Val Ser Gly Leu Met 145 150 155 160 Ile Ile Leu Pro Pro Leu Ser Leu Gly Leu Gln Leu Glu Phe Cys Asp 165 170 175 Ser Asn Ala Ile Asp His Phe Ser Cys Asp Ala Gly Pro Leu Leu Lys 180 185 190 Ile Ser Cys Ser Asp Thr Trp Met Ile Glu Gln Met Val Ile Leu Val 195 200 205 Ala Val Phe Ala Leu Ile Ile Thr Leu Val Cys Val Phe Leu Ser Tyr 210 215 220 Thr Tyr Ile Ile Arg Thr Ile Leu Arg Phe Pro Ser Val Gln Gln Arg 225 230 235 240

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Lys Lys Ala Phe Ser 245 Thr Cys Ser Ser His Met Ile Val Val Ser Ile 250 255 Thr Tyr Gly Ser Cys Ile Phe Ile Tyr Val Lys Pro Ser Ala Lys Glu 260 265 270 Glu Ile Ala Ile Asn Lys Gly Val Ser Val Leu Thr Thr Ser Val Ala 275 280 285 Pro Leu Leu Asn Pro Phe Ile Tyr Thr Leu Arg Asn Lys Gln Val Lys 290 295 300 Gln Ala Phe Asn Asp Phe Ile Lys Lys Met Thr Phe His Ser Met Lys 305 310 315 320 Leu Lys Phe

<210> 2135 <211> 912 <212> DNA <213> Canis familiaris <400> 2135

atgagaaacc aaacggcact aacaactttc atcttgctgg gactcacaga ggaccctcaa 60 ctaaaaattt tgctttttat gtttctgttt ctttcctaca tgttgaatgt atctggaaac 120 ctaaccatca tcatcctcac tctgattgat tcccacctta aaacaccaat gtatcttttc 180 ttccaaaatt tctccttcct agaaatttca ttcacaactg cttgtgtccc cagattttta 240 tatagcatat cattggggga caaatccatt acctatcatg cttgtgtcag tcaactgttg 300 tttacagacc tctttgcagt aacagaattt tttctcttgg ccactatgtc ctatgatccc 360 tatgtggcca tctgcaaacc cctgcattac atgaccatca tgagcagaag agtctgcaag 420 aacttcatcg tcttctgttg ggtagcagca ctgatcatca ttctcccacc aattagtcta 480 ggtttgggcc tggaattctg tgattcaaac atgattgatc atttttgttg tgatgcatct 540 cctatcctga agatctcttg ctcagacaca tggttgaaag aacagatggt tatagtctgt 600 gctgtgttga cattcatcat caccctcatg tgtgtagttc tttcttacat ttatattatc 660

Page 2387

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gggaccattc taaggtttcc ctctgctcag caaaggaaaa aggtcttttc cacttgttct 720 tcccacatga ttgttgtttc cattacttat ggtagctgta tcttcattta tgtcaaacct 780 tcagccaagg atgaggtagc tattaataaa gggatttcac tccttattac ttctatctca 840 ccaatgttga atccctttat ttacacactg agaaacaagc aagtgaagaa agcttttcat 900 gattcaattt aa 912

<210> 2136 <211> 303 <212> PRT <213> Canis familiaris

<400> 2136 Gln Thr 5 Ala Leu Thr Thr Phe Ile Leu Leu Gly Leu Thr Met 1 Arg Asn 10 15 Glu Asp Pro Gln Leu Lys Ile Leu Leu Phe Met Phe Leu Phe Leu Ser 20 25 30 Tyr Met Leu Asn Val Ser Gly Asn Leu Thr Ile Ile Ile Leu Thr Leu 35 40 45 Ile Asp Ser His Leu Lys Thr Pro Met Tyr Leu Phe Phe Gln Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Phe Thr Thr Ala Cys Val Pro Arg Phe Leu 65 70 75 80 Tyr Ser Ile Ser Leu Gly Asp Lys Ser Ile Thr Tyr His Ala Cys Val 85 90 95 Ser Gln Leu Leu Phe Thr Asp Leu Phe Ala Val Thr Glu Phe Phe Leu 100 105 110 Leu Ala Thr Met Ser Tyr Asp Pro Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Ser Arg Arg Val Cys Lys Asn Phe Ile Val 130 135 140

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Phe 145 Cys Trp Val Ala Ala 150 Leu Ile Ile Ile Leu Pro Pro Ile Ser Leu 155 160 Gly Leu Gly Leu Glu Phe Cys Asp Ser Asn Met Ile Asp His Phe Cys 165 170 175 Cys Asp Ala Ser Pro Ile Leu Lys Ile Ser Cys Ser Asp Thr Trp Leu 180 185 190 Lys Glu Gln Met Val Ile Val Cys Ala Val Leu Thr Phe Ile Ile Thr 195 200 205 Leu Met Cys Val Val Leu Ser Tyr Ile Tyr Ile Ile Gly Thr Ile Leu 210 215 220 Arg Phe Pro Ser Ala Gln Gln Arg Lys Lys Val Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile 245 250 255 Tyr Val Lys Pro Ser Ala Lys Asp Glu Val Ala Ile Asn Lys Gly Ile 260 265 270 Ser Leu Leu Ile Thr Ser Ile Ser Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Lys Lys Ala Phe His Asp Ser Ile 290 295 300

<210> 2137 <211> 960 <212> DNA <213> Canis familiaris <400> 2137 atgagaaacc acacagaact aacagacttt atcctcctgg gattgtcaga tgacccacag cttcaggagg tgatctttgt ctttctgctc atcacctaca ttctcagcat cactgggaac ctgaccatta tcaccctcac cctgctggat tcccacctcc agacccccat gtatttcttc Page 2389

120

180

069269_0225_SL.TXT

ctcagaaact tctccttact tgagatttca ttcacaactg tgagcatacc caagttcctg 240 ggcaccctga ttacaggaga taaaactgtt tcctttaatg attgtatggc tcagttattt 300 tttgttattt ttttcattct tttgggagtc actgaatttt acctgctggc tgccatgtcc 360 tatgacagat acattgccat cggcaaacct ctgcattata tgaccatcat gaatcccaga 420 gtctgcatac tccttgtctt tgcttcttgg tcggcttcat tcttaatcat attcccatca 480 ctcatgctgt tcatacagct tgattattgt aagtccaatg ttatacacca ttttacctgt 540 gactatttcc ccttgctaca tctttcttgt tcagacacta gattcttaga gatagtgggt 600 ttttcctgtg ctgtgtttat gttaatgttc acattggtga taataattct gtcatacata 660 tatatcctca gaacaatttt gaggattcct tctactagtc agaggacaaa ggccttttcc 720 acctgttgtt cttcccacat gattgtcatc tctatctcct atggcagctg cattttcatg 780 tatattaacc cagcagcaaa agagcccagc agcaaaagag tgtctctgag caagggagtt 840 gctgtgctag acacgttggt agctcccatg ctgaacccct ttatttacag cctaaggaac 900 cagcaagtca agcgagcctt cctggacagg gcaaggaaga ttgtattttt ctcaagcaaa 960

<210> 2138 <211> 320 <212> PRT <213> Canis familiaris

<400> 2138 Met 1 Arg Asn His Thr Glu 5 Leu Thr Asp Phe 10 Ile Leu Leu Gly Leu Ser 15 Asp Asp Pro Gln Leu Gln Glu Val Ile Phe Val Phe Leu Leu Ile Thr 20 25 30 Tyr Ile Leu Ser Ile Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Leu Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Leu Leu Glu Ile Ser Phe Thr Thr Val Ser Ile Pro Lys Phe Leu 65 70 75 80

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Gly Thr Leu Ile Thr 85 Gly Asp Lys Thr Val Ser Phe Asn Asp Cys Met 90 95 Ala Gln Leu Phe Phe Val Ile Phe Phe Ile Leu Leu Gly Val Thr Glu 100 105 110 Phe Tyr Leu Leu Ala Ala Met Ser Tyr Asp Arg Tyr Ile Ala Ile Gly 115 120 125 Lys Pro Leu His Tyr Met Thr Ile Met Asn Pro Arg Val Cys Ile Leu 130 135 140 Leu Val Phe Ala Ser Trp Ser Ala Ser Phe Leu Ile Ile Phe Pro Ser 145 150 155 160 Leu Met Leu Phe Ile Gln Leu Asp Tyr Cys Lys Ser Asn Val Ile His 165 170 175 His Phe Thr Cys Asp Tyr Phe Pro Leu Leu His Leu Ser Cys Ser Asp 180 185 190 Thr Arg Phe Leu Glu Ile Val Gly Phe Ser Cys Ala Val Phe Met Leu 195 200 205 Met Phe Thr Leu Val Ile Ile Ile Leu Ser Tyr Ile Tyr Ile Leu Arg 210 215 220 Thr Ile Leu Arg Ile Pro Ser Thr Ser Gln Arg Thr Lys Ala Phe Ser 225 230 235 240 Thr Cys Cys Ser Ser His Met Ile Val Ile Ser Ile Ser Tyr Gly Ser 245 250 255 Cys Ile Phe Met Tyr Ile Asn Pro Ala Ala Lys Glu Pro Ser Ser Lys 260 265 270 Arg Val Ser Leu Ser Lys Gly Val Ala Val Leu Asp Thr Leu Val Ala 275 280 285

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Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Gln Gln Val Lys 290 295 300 Arg Ala Phe Leu Asp Arg Ala Arg Lys Ile Val Phe Phe Ser Ser Lys

305 310 315 320 <210> 2139 <211> 939 <212> DNA <213> Canis familiaris <400> 2139

atgaaaaacc acacagtacc cacagagttc attcttctag ggctatcaga tgacccagag 60 tttcagattg tgatttttct ctttttaatt atcacataca tattcagtgt cactggaaat 120 ttgaccatca tcactctcac cttggtggac tcccatctac agacccctat gtatttcttc 180 ctcaggaact tctctgtatt agaaatatcc tttacaaccg tctgtattcc taggtttctg 240 ggcacaatta tcaccagaga caaaactatt tcatacaata attgtacagc tcagttgttt 300 ttcttcatct tcatgggcat aactgagttt tatcttctaa ctgctatgtc ctatgatcgc 360 tatgtagcca tctgtaaacc cttgcattac acgactatca tgaacaaaag agtctgcatt 420 ttacttgtct tttgtgcatg gctggcagga ttcttaaata tcttcccgcc agttattctt 480 ttcctccagt tagattactg tggctccaat gtcattgatc actttgcttg tgactatttt 540 cccctcttgc aattatcttg ctcagacaca tggctcctag aagtgattgg tttttactct 600 gcaatagtga ttctgctttt cactctggca ctaataattc tatcctacat gttcatcatt 660 agaacaattc tgaaactgcc atctgccagt cagagaaaaa aggcattttc tacatgctcc 720 tcgcacatga ttgtcatttc catctcttat ggaagctgca tattcatgta tgccaacccc 780 tctgcaaaag aaaaggcatc cttgaccaaa ggagtagcta ttcttaatac ttctgttgct 840 cctatgatga atccatttat atatactctg aggaatcagc aagtaaaaca agcctttaag 900 gatactatcc aaaaggttct gtttttctcc agtaaatga 939

<210> 2140 <211> 312 <212> PRT

Page 2392

069269_0225_SL.TXT <213> Canis familiaris <400> 2140

Met 1 Lys Asn His Thr Val Pro Thr Glu Phe Ile Leu Leu Gly Leu Ser 5 10 15 Asp Asp Pro Glu Phe Gln Ile Val Ile Phe Leu Phe Leu Ile Ile Thr 20 25 30 Tyr Ile Phe Ser Val Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Val Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Val Leu Glu Ile Ser Phe Thr Thr Val Cys Ile Pro Arg Phe Leu 65 70 75 80 Gly Thr Ile Ile Thr Arg Asp Lys Thr Ile Ser Tyr Asn Asn Cys Thr 85 90 95 Ala Gln Leu Phe Phe Phe Ile Phe Met Gly Ile Thr Glu Phe Tyr Leu 100 105 110 Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Asn Lys Arg Val Cys Ile Leu Leu Val Phe 130 135 140 Cys Ala Trp Leu Ala Gly Phe Leu Asn Ile Phe Pro Pro Val Ile Leu 145 150 155 160 Phe Leu Gln Leu Asp Tyr Cys Gly Ser Asn Val Ile Asp His Phe Ala 165 170 175 Cys Asp Tyr Phe Pro Leu Leu Gln Leu Ser Cys Ser Asp Thr Trp Leu 180 185 190 Leu Glu Val Ile Gly Phe Tyr Ser Ala Ile Val Ile Leu Leu Phe Thr

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195 200 Tyr Met Phe Ile Ile 220 205 Leu Ala Leu 210 Ile Ile Leu Ser 215 Arg Thr Ile Leu Lys Leu Pro Ser Ala Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Ile Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ala Asn Pro Ser Ala Lys Glu Lys Ala Ser Leu Thr Lys Gly Val 260 265 270 Ala Ile Leu Asn Thr Ser Val Ala Pro Met Met Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asp Thr Ile Gln 290 295 300 Lys Val Leu Phe Phe Ser Ser Lys 305 310

<210> 2141 <211> 945 <212> DNA <213> Canis familiaris <400> 2141

atgagaaacc acacagaaat aacagatttt atcctcctgg gattgtcaga tgacccacag 60 cttcaggagg tgatctttgt ctttctgctt atcacctaca tgctcagcat cactgggaac 120 ctgacaatta tcaccctcac cctgctggat tcccacctcc agacccccat gtatttcttc 180 ctcagaaact tctccttact tgagatttca ttcacaactg tgagcatacc caagttcctg 240 agcaccctga ttacaggaga taaaaacatt tcctttaatg attgcatggc tcagttcttt 300 ttttttttaa tcttcttggg agtcactgaa ttttgccttc tggctgccat gtcctatgac 360 agatacattg ccatctgcaa acctctgcat tacatgacca tcatgaatcc cagagtctgc 420 atactccttg tctttgcttc ttggtcggct tcattcttaa tcatattccc atcactcatg 480

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ctgttcatac agcttgatta ttgtaagtcc aatgttatac accattttac ctgtgactat 540 ttccccttac tacattacat ttcttgttca gacactagat tcctagagat agtgggtttt 600 tcctgtgctg tgtttacatt aatgttcaca ttggcattaa taattctgtc ctacatatat 660 atcctcagaa caattttgag gattccttct actagtcaga ggacaaaggc tttttccacc 720 tgttgttctt cccacatgat tgtcatctcc atctcctatg gcaactgcat tttcatgtat 780 attaacccag cagcaaaaga cagagtgtct ctgagcaagg gagttgctgt gctaaacacc 840 tcggtagccc ccatgctgaa cccctttatt tacagcctaa ggaaccagca agtcaagcga 900 gccttcctgg acagggcaag gaagattgta tttttctcaa gcaaa 945

<210> 2142 <211> 315 <212> PRT <213> Canis familiaris

<400> 2142 Glu Ile Thr Asp Phe Ile Leu Leu Gly Leu Ser Met Arg 1 Asn His Thr 5 10 15 Asp Asp Pro Gln Leu Gln Glu Val Ile Phe Val Phe Leu Leu Ile Thr 20 25 30 Tyr Met Leu Ser Ile Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Leu Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Leu Leu Glu Ile Ser Phe Thr Thr Val Ser Ile Pro Lys Phe Leu 65 70 75 80 Ser Thr Leu Ile Thr Gly Asp Lys Asn Ile Ser Phe Asn Asp Cys Met 85 90 95 Ala Gln Phe Phe Phe Phe Leu Ile Phe Leu Gly Val Thr Glu Phe Cys 100 105 110

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Leu Leu Ala Ala 115 Met Ser Tyr Asp Arg Tyr Ile Ala Ile Cys Lys Pro 120 125 Leu His Tyr Met Thr Ile Met Asn Pro Arg Val Cys Ile Leu Leu Val 130 135 140 Phe Ala Ser Trp Ser Ala Ser Phe Leu Ile Ile Phe Pro Ser Leu Met 145 150 155 160 Leu Phe Ile Gln Leu Asp Tyr Cys Lys Ser Asn Val Ile His His Phe 165 170 175 Thr Cys Asp Tyr Phe Pro Leu Leu His Tyr Ile Ser Cys Ser Asp Thr 180 185 190 Arg Phe Leu Glu Ile Val Gly Phe Ser Cys Ala Val Phe Thr Leu Met 195 200 205 Phe Thr Leu Ala Leu Ile Ile Leu Ser Tyr Ile Tyr Ile Leu Arg Thr 210 215 220 Ile Leu Arg Ile Pro Ser Thr Ser Gln Arg Thr Lys Ala Phe Ser Thr 225 230 235 240 Cys Cys Ser Ser His Met Ile Val Ile Ser Ile Ser Tyr Gly Asn Cys 245 250 255 Ile Phe Met Tyr Ile Asn Pro Ala Ala Lys Asp Arg Val Ser Leu Ser 260 265 270 Lys Gly Val Ala Val Leu Asn Thr Ser Val Ala Pro Met Leu Asn Pro 275 280 285 Phe Ile Tyr Ser Leu Arg Asn Gln Gln Val Lys Arg Ala Phe Leu Asp 290 295 300 Arg Ala Arg Lys Ile Val Phe Phe Ser Ser Lys 305 310 315

Page 2396

069269_0225_SL.TXT <210> 2143 <211> 936 <212> DNA <213> Canis familiaris <400> 2143

atgaaccaca cagtgatcac tgagtttgtc ctgctaggcc tttctgatga tcctgacctt 60 cagattgtga ttttcctctt cttattcctc acatacttac tcagtgtcac tggaaacctg 120 actatcatca ccctaacctt ggtggactct catctacaga cgccaatgta tttcttcctc 180 cgaaacttct ctttcttaga aatcttattt acaactgtat gtattcctag atttctgggg 240 gcaattatca ccagggataa gactatttcc tataacaact gtgcagccca gctgtttttc 300 tttattttca tgggggtgac ggaattttac attctcactg ccatgtctta tgaccgctat 360 gttgccatct gcaagcccct tcattatacc accatcatga acaggaaggt ctgcacccta 420 cttgtgctct gtgcatggct tggtgggttc ctgaccattt tcccacccct tatgcttcta 480 ctccagctgg attactgtgc ttccaatgtc attgaccact ttgcatgtga ctattttccc 540 cttttacaac tgtcttgttc agatacgtgg ctcctagagg taattggttt ctactttgct 600 ttagttgcct tgctattcac tttggccttg gtgattttat cttatttgta tataatcaga 660 actattttga gaatcccatc tgccagtcag agaaaaaagg ctttctccac gtgttcttct 720 catatgattg tcatttccat ctcttatggg agctgtatat ttatgtatgc taatccttct 780 gcaaaagaaa gggcatcatt gaccaaagga gtagctattc tcaatacttc tgttgccccc 840 atgctgaacc ccttcattta cactctgaga aaccagcaag taaaacaagc tttcaaagat 900 gtggtccata aagtagtatt ttcttcaagt aaatga 936

<210> 2144 <211> 311 <212> PRT <213> Canis familiaris

<400> 2144 Met Asn His Thr Val Ile Thr Glu Phe Val Leu Leu Gly Leu Ser Asp 1 5 10 15

Asp Pro Asp Leu Gln Ile Val Ile Phe Leu Phe Leu Phe Leu Thr Tyr 20 25 30

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Leu Leu Ser 35 Val Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu Val 40 45 Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe Ser 50 55 60 Phe Leu Glu Ile Leu Phe Thr Thr Val Cys Ile Pro Arg Phe Leu Gly 65 70 75 80 Ala Ile Ile Thr Arg Asp Lys Thr Ile Ser Tyr Asn Asn Cys Ala Ala 85 90 95 Gln Leu Phe Phe Phe Ile Phe Met Gly Val Thr Glu Phe Tyr Ile Leu 100 105 110 Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His 115 120 125 Tyr Thr Thr Ile Met Asn Arg Lys Val Cys Thr Leu Leu Val Leu Cys 130 135 140 Ala Trp Leu Gly Gly Phe Leu Thr Ile Phe Pro Pro Leu Met Leu Leu 145 150 155 160 Leu Gln Leu Asp Tyr Cys Ala Ser Asn Val Ile Asp His Phe Ala Cys 165 170 175 Asp Tyr Phe Pro Leu Leu Gln Leu Ser Cys Ser Asp Thr Trp Leu Leu 180 185 190 Glu Val Ile Gly Phe Tyr Phe Ala Leu Val Ala Leu Leu Phe Thr Leu 195 200 205 Ala Leu Val Ile Leu Ser Tyr Leu Tyr Ile Ile Arg Thr Ile Leu Arg 210 215 220 Ile Pro Ser Ala Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240

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His Met Ile Val Ile Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met Tyr 245 250 255 Ala Asn Pro Ser Ala Lys Glu Arg Ala Ser Leu Thr Lys Gly Val Ala 260 265 270 Ile Leu Asn Thr Ser Val Ala Pro Met Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asp Val Val His Lys 290 295 300 Val Val Phe Ser Ser Ser Lys

305 310 <210> 2145 <211> 210 <212> DNA <213> Canis familiaris <400> 2145 gtggtggtgg cagccttttc tgttgtcttg gtggcttctt acatattcat atcacataat cttaggaccc actcctccgc cgggtaatgc aaagctctct ccacctgcag ctctcatgta atggtggtag ttttattctt catgccctgt atctgtactt aggttctacc tgcagggagt gagaacagag atgaggaact ctccatattt

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210 <210> 2146 <211> 39 <212> PRT <213> Canis familiaris

<400> 2146 Trp Trp Trp Gln Pro Phe Leu Leu Ser Trp Trp Leu Leu Thr Tyr Ser 1 5 10 15 Tyr His Ile Ile Leu Gly Pro Thr Pro Pro Pro Gly Asn Ala Lys Leu 20 25 30 Ser Pro Pro Ala Ala Leu Met 35

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069269_0225_SL.TXT <210> 2147 <211> 921 <212> DNA <213> Canis familiaris <400> 2147

atggagagcc agaggaatgt ctcagaattc attcttttgg gactctcgca tgaccagaac 60 atgcaaatat tttgctttgt gctcttctta ttctgttatg ctgctctctt ggtaggaaac 120 cttctgatcc ttgtctctat tcgatgcagc cctctttttc accaaccgat gtactacttc 180 ctcagccact tatccacttt ggacatctgc tatatctcta gcgttacacc caaattaatt 240 gctgacctgc tagtggaaag aaaagccatc tcctatggta attgtatgtt acagatcttt 300 gccatgcact tctttggaac gattgaggtt ttaattctta cagtcatggc ctttgatcac 360 tatgctgcca tctgcaaacc tctccactac ctgcttatca tgaacaggac aaggtgcaat 420 ctcctagtct tagctgcttg ggctggtggg gccgtccact cctttcctca attttgtatg 480 gtaatcaggt tgcccttctg tgggcctaat gagattgatc actatttctg tgatatattt 540 cctttgctaa aggttgcctg cactgatacc tacatcactg gtgtccttat ggttgccaat 600 tctggaatgg ttaccttggt gacatttgtg gttttatttt tttcgttctt tcgttcgaat 660 gtcattatat tattcacttt aagaaatcac tcagcggaag gaagacgcaa agccctctct 720 acctgtggat ctcacatcac agttatagtt ttattttttg ggccttccat ctttgcctac 780 cttagacctc caaccaattt ccctgaggat aaaatatttg ctctgtttta caccatcatt 840 gctcctatgt tcaatccctt aatctatact ctgagaaatt cagagatgaa aaatgccatg 900 agaaaatttt ggtgccaaac a 921

<210> 2148 <211> 307 <212> PRT <213> Canis familiaris

<400> 2148 Met Glu Ser Gln Arg Asn Val Ser Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15 His Asp Gln Asn Met Gln Ile Phe Cys Phe Val Leu Phe Leu Phe Cys 1 Page 2400

069269_0225_SL.TXT 25 30

Tyr Ala Ala 35 Leu Leu Val Gly Asn Leu Leu Ile Leu Val Ser Ile Arg 40 45 Cys Ser Pro Leu Phe His Gln Pro Met Tyr Tyr Phe Leu Ser His Leu 50 55 60 Ser Thr Leu Asp Ile Cys Tyr Ile Ser Ser Val Thr Pro Lys Leu Ile 65 70 75 80 Ala Asp Leu Leu Val Glu Arg Lys Ala Ile Ser Tyr Gly Asn Cys Met 85 90 95 Leu Gln Ile Phe Ala Met His Phe Phe Gly Thr Ile Glu Val Leu Ile 100 105 110 Leu Thr Val Met Ala Phe Asp His Tyr Ala Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Leu Ile Met Asn Arg Thr Arg Cys Asn Leu Leu Val Leu 130 135 140 Ala Ala Trp Ala Gly Gly Ala Val His Ser Phe Pro Gln Phe Cys Met 145 150 155 160 Val Ile Arg Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Ile Phe Pro Leu Leu Lys Val Ala Cys Thr Asp Thr Tyr Ile 180 185 190 Thr Gly Val Leu Met Val Ala Asn Ser Gly Met Val Thr Leu Val Thr 195 200 205 Phe Val Val Leu Phe Phe Ser Phe Phe Arg Ser Asn Val Ile Ile Leu 210 215 220 Phe Thr Leu Arg Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser

Page 2401

0 6926 9_02 25_S L.TX T 225 230 235 240 Thr Cys Gly Ser His Ile Thr Val Ile Val Leu Phe Phe Gly Pro Ser 245 250 255 Ile Phe Ala Tyr Leu Arg Pro Pro Thr Asn Phe Pro Glu Asp Lys Ile 260 265 270 Phe Ala Leu Phe Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile 275 280 285 Tyr Thr Leu Arg Asn Ser Glu Met Lys Asn Ala Met Arg Lys Phe Trp 290 295 300

Cys Gln Thr 305 <210> 2149 <211> 846 <212> DNA <213> Canis familiaris <400> 2149

atgactgggg gaggaaatac tacagagatc acttatttca tccttttggg attctctgat 60 ttccccagaa tcctagcagt gctctttgct gtattcctgc tgatttacat tttgactctg 120 acttggaacc tgggcctcat catcttaata aggatggact ctcacctcca cacacccatg 180 tacttcttcc tcagtaatct gtccttcata gatgtctgct atgtgacctc tacagctccc 240 aagatgctct ccaacttttt ccaagagcag caaaccatca cctttgtggg ttgtgccgtt 300 cagtactttg tcttttcaac catgggactg agtgagtctt gtctcatgac agccatggct 360 tatgaccgat acactgccat ttgtaatcca cttctctatt catcagtcat gtcacccacg 420 ctctgtattc agatggtgct gggatcctat ctggctgcac tctctgctag tatatcccag 480 ttgtgtgcca tgtttcagct tcatttctgt gggcctaatg tcatcaatca cttcttctgt 540 gacatgcccc aactattaat cctgtcctgc actgacactt tctttgtaca tctgttgatt 600 gctatactag caacgatctt tgggatgata aatgccttta ttattatgat atcctatggc 660 tatattgtca tgtccatcat gaaaatcact tcagctaaag gcagatccaa agctttcaac 720

Page 2402

069269_0225_SL.TXT acctgtgctt ctcatctgac agcagtttct ctcttctata cctcaagtgt ctttgtttat ttgagttcca gctctggtgg ttcctccagc tttgacagat ttgcatcagt attctacact gtggtt

780

840

846 <210> 2150 <211> 282 <212> PRT <213> Canis familiaris

<400> 2150 Asn Thr Thr Glu Ile Thr Tyr Phe Ile Leu Leu Met Thr 1 Gly Gly Gly 5 10 15 Gly Phe Ser Asp Phe Pro Arg Ile Leu Ala Val Leu Phe Ala Val Phe 20 25 30 Leu Leu Ile Tyr Ile Leu Thr Leu Thr Trp Asn Leu Gly Leu Ile Ile 35 40 45 Leu Ile Arg Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Phe Ile Asp Val Cys Tyr Val Thr Ser Thr Ala Pro 65 70 75 80 Lys Met Leu Ser Asn Phe Phe Gln Glu Gln Gln Thr Ile Thr Phe Val 85 90 95 Gly Cys Ala Val Gln Tyr Phe Val Phe Ser Thr Met Gly Leu Ser Glu 100 105 110 Ser Cys Leu Met Thr Ala Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Ser Ser Val Met Ser Pro Thr Leu Cys Ile Gln 130 135 140 Met Val Leu Gly Ser Tyr Leu Ala Ala Leu Ser Ala Ser Ile Ser Gln 145 150 155 160

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Leu Cys Ala Met Phe Gln Leu His Phe Cys Gly Pro Asn Val Ile Asn 165 170 175 His Phe Phe Cys Asp Met Pro Gln Leu Leu Ile Leu Ser Cys Thr Asp 180 185 190 Thr Phe Phe Val His Leu Leu Ile Ala Ile Leu Ala Thr Ile Phe Gly 195 200 205 Met Ile Asn Ala Phe Ile Ile Met Ile Ser Tyr Gly Tyr Ile Val Met 210 215 220 Ser Ile Met Lys Ile Thr Ser Ala Lys Gly Arg Ser Lys Ala Phe Asn 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Tyr Thr Ser Ser 245 250 255 Val Phe Val Tyr Leu Ser Ser Ser Ser Gly Gly Ser Ser Ser Phe Asp 260 265 270 Arg Phe Ala Ser Val Phe Tyr Thr Val Val 275 280

<210> 2151 <211> 915 <212> DNA <213> Canis familiaris <400> 2151 atggtgatga atagcactgt gaatgaattc attctgtttg gcttgacaca ggatccaaga aaacagaaag caatatttgg ggtcttcttg atgctttatc ttgccacact gttgggaaat tttctcattg tagtgactat taaaagaagc aggacccttg ggagtcccat gtacttcttc ctattttacc tgtcctttac tgatgcttgc ctctctacaa ccattatccc cagattgatt gtggatgcca tttctcagag gaagaccatt tcctacaatg agtgcatgac tcaggtcttt tcagcccact tctttggatg catggaaatc ttcgtgctga tcgtcatggc ttttgatcgc

120

180

240

300

360

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tatgtagcca tttgtaagcc cttgcgatac acaaccatca tgaacaggca tgtctgcagt 420 gtgctggtga ttctgggttg ggtgggatcc tgtatccact cttcggcaca aattgtcctg 480 gctttgagat tgcctttctg tggtcccaat gtgattgatc actatttctg tgacttgcag 540 cccttgttga aacttgcttg catggacact tatgtaataa atttgctagt tgtttctaac 600 agtggagcca tatgcacggt gagtttcata atcctgctta tctcctatgt tatcatcttg 660 tactctctga gaaactacag tgcagaagga aggcgaaaag ccctttcaac ctgcacctcc 720 cattttattg tggttgtcct attttttggc ccatgtatat tcatatatac acgtccggca 780 accacatttc cagtagacaa ggtggtggct gtgttttata ccattggggc acccttgctc 840 aaccctctga tctatacact gaggaatgcg gaagtgaaaa atgccatgaa aaagttatgg 900 tgtaacaaag tgtga 915 <210> 2152 <211> 304 <212> PRT <213> Canis familiaris <400> 2152 Met Val Met Asn Ser Thr Val Asn Glu Phe Ile Leu Phe Gly Leu Thr 1 5 10 15 Gln Asp Pro Arg Lys Gln Lys Ala Ile Phe Gly Val Phe Leu Met Leu 20 25 30 Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45 Arg Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Thr Asp Ala Cys Leu Ser Thr Thr Ile Ile Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Ile Ser Gln Arg Lys Thr Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ser Ala His Phe Phe Gly Cys Met Glu Ile Phe Val

Page 2405

100

069269_0225_SL.TXT 105 110

Leu Ile Val Met Ala 115 Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 120 125 Arg Tyr Thr Thr Ile Met Asn Arg His Val Cys Ser Val Leu Val Ile 130 135 140 Leu Gly Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Val Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Val Val Ser Asn Ser Gly Ala Ile Cys Thr Val Ser 195 200 205 Phe Ile Ile Leu Leu Ile Ser Tyr Val Ile Ile Leu Tyr Ser Leu Arg 210 215 220 Asn Tyr Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Phe Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Ala Thr Thr Phe Pro Val Asp Lys Val Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Ala Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Cys Asn Lys Val 290 295 300

<210> 2153

Page 2406

069269_0225_SL.TXT <211> 924 <212> DNA <213> Canis familiaris <400> 2153

cactttcaag attttgtact agagggattt aggggtggtc tggagaccca agccatgctc 60 ttcactgtct tcttggcctt gtacatggtg actatactgg gcaacttcct catgatcatc 120 tttagcaccc tggatgcctg cctacacttc ccaatgtatg tcttcctcaa gaacccctcc 180 ttcatggact tgtgctactc atctgttatt acccccaatg caccggccaa ctacttctcc 240 tcatccaagg tcatcacctt tacagaatgt gccacccagt ttttcttttt atccctggtg 300 gctaccactg aatgcttcct cctgggtgtt atgtcctacg accacttcat ggccatttgt 360 agacacttga gctaccctag caccatgtgc cagtctggct gcactcgcct ggtgctgtgc 420 acctactgtg gaggctgctt caactctggt gcagagaagc ttcacattca acctctcatt 480 ctgcagctcc aactgcatca accacgtcct ctgtgatgtg ccccctctgt tccatatcgc 540 ctgtggcaag acggccatca atgaacttct cttgtttggc atctgtgggc tcatgattgt 600 gggtgtgaca tatatggtcc tcatctccta tggttacata atagtgacca tcctgaggat 660 gggctcagga gcggtagatg caagatcttc tccacctgtg gctcccacat gactgcaatg 720 accctctttt tgggatttgg gaccgtcttt gtaatatata cccagccagg agcaactgag 780 tccatggagc agggcaaggt ggtctctgtc ttctacacgc tggtcatccc agagctcaat 840 cccctcatct acagtctgca aaacaaggat gtgaaggagg ctgtgtggag gctgggccag 900 aaacacatgg ccacgtgaag gatg 924

<210> 2154 <211> 171 <212> PRT <213> Canis familiaris <400> 2154

His Phe Gln Asp Phe Val Leu Glu Gly Phe Arg Gly Gly Leu Glu Thr 1 5 10 15 Gln Ala Met Leu Phe Thr Val Phe Leu Ala Leu Tyr Met Val Thr Ile

20 25 30

Page 2407

Leu Gly Asn 35 Phe Leu Met Ile 069269_0225_SL.TXT Ile Phe Ser Thr Leu Asp 40 45 Ala Cys Leu His Phe Pro Met Tyr Val Phe Leu Lys Asn Pro Ser Phe Met Asp Leu 50 55 60 Cys Tyr Ser Ser Val Ile Thr Pro Asn Ala Pro Ala Asn Tyr Phe Ser 65 70 75 80 Ser Ser Lys Val Ile Thr Phe Thr Glu Cys Ala Thr Gln Phe Phe Phe 85 90 95 Leu Ser Leu Val Ala Thr Thr Glu Cys Phe Leu Leu Gly Val Met Ser 100 105 110 Tyr Asp His Phe Met Ala Ile Cys Arg His Leu Ser Tyr Pro Ser Thr 115 120 125 Met Cys Gln Ser Gly Cys Thr Arg Leu Val Leu Cys Thr Tyr Cys Gly 130 135 140 Gly Cys Phe Asn Ser Gly Ala Glu Lys Leu His Ile Gln Pro Leu Ile 145 150 155 160 Leu Gln Leu Gln Leu His Gln Pro Arg Pro Leu 165 170

<210> 2155 <211> 1077 <212> DNA <213> Canis familiaris <400> 2155 atggagggtg caaacctgtc agcagtgacg gaatttgtct tcactggctt cccccagctc caggatggtg gcctcctgta cttcttcccc ttactcttca tctacacctt tgttgtcgtt gggaatctat tgatcttctt tgcggtcagg atggatgtcc gcctccacaa ccccatgtac aacttcatca gcaccttctc cttcctggag gtctggtaca ccacagccac catccccaag atgctctcca acctggtcag tgagaagaaa accatctcca tgaccggctg cctcctgcag

120

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atgtacttct tccattccct tgggaattca gaggcgatct tgctgatcac tatggccatt 360 gacaggtacg tggccatctg caaccctctc cgctaccaga tgatcatgac cccccggctg 420 tgtgctcagc tgtctgcagg ctcctgcatc tttggcttcc tcatcctact tcctgagatt 480 gtaacgattt ccacactgcc cttctgtggg cccaaccaaa tccatcagat cttctgtgac 540 ttggtgccag tgctgaggct ggcctgtaca aacgcgtccg tgattctggt tgaagatgtg 600 atccacgctg tggccatcat catcaccatc ctaatcattg ccctatccta catcagaatc 660 gtctctgtga tcctgaggat cccctctgct gagggtcggc agaaggcctt ttctacctgt 720 gggggccatc tcactgtctt cctgattttc tttggcagtg tgtccctcat gtacttgcgt 780 ttcaatgcca cctacccccc agctttggac acagccattg cactgatgtt tactgtcctt 840 gctccattct tccaccccat catttatagt ctgagaaaca aggacatgaa gaatgcaatt 900 agaaaactcg tccaggggat ccctgggtgg ctcagtggtt tggcgcctgc ctttggccca 960 aggcgcgatc ctggagtccc gggatcgagt cccacgtcag gctcccggtg catggagcct 1020 gcttctccct ctgcctgtat ctgtctgtct gtctctctct ctgtctatca taaataa 1077

<210> 2156 <211> 358 <212> PRT <213> Canis familiaris <400> 2156

Met Glu Gly Ala Asn Leu Ser Ala Val Thr Glu Phe Val Phe Thr Gly 1 5 10 15 Phe Pro Gln Leu Gln Asp Gly Gly Leu Leu Tyr Phe Phe Pro Leu Leu 20 25 30 Phe Ile Tyr Thr Phe Val Val Val Gly Asn Leu Leu Ile Phe Phe Ala 35 40 45 Val Arg Met Asp Val Arg Leu His Asn Pro Met Tyr Asn Phe Ile Ser 50 55 60 Thr Phe Ser Phe Leu Glu Val Trp Tyr Thr Thr Ala Thr Ile Pro Lys 65 70 75 80

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Met Leu Ser Asn Leu Val Ser Glu 85 Lys Lys Thr Ile Ser Met Thr Gly 90 95 Cys Leu Leu Gln Met Tyr Phe Phe His Ser Leu Gly Asn Ser Glu Ala 100 105 110 Ile Leu Leu Ile Thr Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Gln Met Ile Met Thr Pro Arg Leu Cys Ala Gln Leu 130 135 140 Ser Ala Gly Ser Cys Ile Phe Gly Phe Leu Ile Leu Leu Pro Glu Ile 145 150 155 160 Val Thr Ile Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His Gln 165 170 175 Ile Phe Cys Asp Leu Val Pro Val Leu Arg Leu Ala Cys Thr Asn Ala 180 185 190 Ser Val Ile Leu Val Glu Asp Val Ile His Ala Val Ala Ile Ile Ile 195 200 205 Thr Ile Leu Ile Ile Ala Leu Ser Tyr Ile Arg Ile Val Ser Val Ile 210 215 220 Leu Arg Ile Pro Ser Ala Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Gly His Leu Thr Val Phe Leu Ile Phe Phe Gly Ser Val Ser Leu 245 250 255 Met Tyr Leu Arg Phe Asn Ala Thr Tyr Pro Pro Ala Leu Asp Thr Ala 260 265 270 Ile Ala Leu Met Phe Thr Val Leu Ala Pro Phe Phe His Pro Ile Ile 275 280 285

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Tyr Ser Leu Arg Asn Lys Asp 295 Met Lys Asn Ala Ile 300 Arg Lys Leu Val 290 Gln Gly Ile Pro Gly Trp Leu Ser Gly Leu Ala Pro Ala Phe Gly Pro 305 310 315 320 Arg Arg Asp Pro Gly Val Pro Gly Ser Ser Pro Thr Ser Gly Ser Arg 325 330 335 Cys Met Glu Pro Ala Ser Pro Ser Ala Cys Ile Cys Leu Ser Val Ser 340 345 350 Leu Ser Val Tyr His Lys

355 <210> 2157 <211> 939 <212> DNA <213> Canis familiaris <400> 2157

atggggggac ggaacgccac caaggtcagc gtcttcgtcc tgctgggctt ccccacggcc 60 cctcggctgc agtacgtgct cttcctcgtc ttcctgctca cctacctctt catcctggtg 120 gagaacctcg tcatcatcgt caccgtccgc cgcagcgccc ccctccacag gcccatgtac 180 tacttcctgg gcgccctgtc tgtcctggag gtctggtacg tgtcggtcat catccccaag 240 atgctggggg ggctcctcct gcagcagaaa ctcatctcct ttgccggctg catgacccag 300 ctctacttct tcagctccct ggtgtgcacc gaatgcgtgc tcctggcctc catggcctac 360 gaccgctacg tggccatctg ccaccccctg cgctaccaag tcatcatgac cacggggctc 420 tgcgtccggc tggtggcctt ctccttcgtc agcggcttct ccatctctat gatcaaggtg 480 ttctttgtct ccagggccac gttctgtggc tccaacgtcc tgaaccactt cttctgtgac 540 atttccccca tcctcaagct ggcctgcacc gacttctcga ccgcggagct ggtggacttc 600 atcctggcct tcatcatcct ggtgtcgccc ctggtggcca ccgtgctgtc ctacgggcac 660 atcaccctgg ccgtcctgcg catcccctcg gccacgggcc gctggagggc cttctccacc 720 tgcgcctccc acctcaccgt ggtcaccatc ttctacacgg ccatgatctt catgtacgtc 780

Page 2411

069269_0225_SL.TXT cggccccagg ccatcgattc ccggagctcc aataagctca tctctgcggt gtacactgtc ctcaccccga taatcaaccc cttgatctac tgcctgagga acaaagaatt taaggctgcc ttgaaaaagg ctctgggctt tggtcaaatt cccacatag

840

900

939 <210> 2158 <211> 313 <212> PRT <213> Canis familiaris

<400> 2158 Thr Lys Ala Gln Ser Leu Phe Gln Gly Ser Leu Leu Cys 1 Gly Asn Leu 5 10 15 Lys Phe Phe Val Pro Gln Ala Val Asp Gln Gly Val Asp Tyr Arg Gly 20 25 30 Glu Asp Ser Val His Arg Arg Asp Glu Leu Ile Gly Ala Pro Gly Ile 35 40 45 Asp Gly Leu Gly Pro Asp Val His Glu Asp His Gly Arg Val Glu Asp 50 55 60 Gly Asp His Gly Glu Val Gly Gly Ala Gly Gly Glu Gly Pro Pro Ala 65 70 75 80 Ala Arg Gly Arg Gly Asp Ala Gln Asp Gly Gln Gly Asp Val Pro Val 85 90 95 Gly Gln His Gly Gly His Gln Gly Arg His Gln Asp Asp Glu Gly Gln 100 105 110 Asp Glu Val His Gln Leu Arg Gly Arg Glu Val Gly Ala Gly Gln Leu 115 120 125 Glu Asp Gly Gly Asn Val Thr Glu Glu Val Val Gln Asp Val Gly Ala 130 135 140 Thr Glu Arg Gly Pro Gly Asp Lys Glu His Leu Asp His Arg Asp Gly 145 150 155 160

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Glu Ala Ala Asp Glu Gly Glu Gly His Gln Pro 165 170 Gly His Asp Asp Leu Val Ala Gln Gly Val Ala 180 185 Val Val Gly His Gly Gly Gln Glu His Ala Phe 195 200 Ala Glu Glu Val Glu Leu Gly His Ala Ala Gly 210 215 Leu Leu Gln Glu Glu Pro Pro Gln His Leu Gly 225 230 235 Val Pro Asp Leu Gln Asp Arg Gln Gly Ala Gln 245 250 Pro Val Glu Gly Gly Ala Ala Ala Asp Gly Asp

260 265 Leu His Gln Asp Glu Glu Val Gly Glu Gln Glu 275 280 Val Leu Gln Pro Arg Gly Arg Gly Glu Ala Gln 290 295 Asp Leu Gly Gly Val Pro Ser Pro His 305 310

Asp Ala Glu Pro 175 Arg Asp Gly His 190 Val Ala Gly Ala 205 His Gln Gly Lys 220 Gly Asp Glu Phe Asp Asp Asp Arg His 240 Glu Val Val His 255 Gly Asp Asp Asp 270 Glu Val Asp Glu 285 Glu Glu His Gln Asp Glu Asp Ala

300 <210> 2159 <211> 939 <212> DNA <213> Canis familiaris <400> 2159 atgagaaacc acacagaact aacagacttt atcctcctgg gattgtcaga tgacccacag cttcaggagg tgatctttgt ctttctgctt atcacctaca tgctcagcat cactgggaac

120

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ctgaccatta tcaccctcac cctgctggat tcccacctcc agacccccat gtatttcttc 180 ctcagaaact tctccttact tgagatttca ttcacaactg tgagcatacc caagttcctg 240 agcaccctga ttacaggaga taaaactgtt tcctttaatg attgtatggc tcagttattt 300 tttttcattc tgttgggagt cactgaattt tacctgctgg ctgccatgtc ctatgaccga 360 tacattgcca tctgcaaacc tctgcattac atgaccatca tgaatcccag agtctgcata 420 ctccttgtct ttgcttcttg gtcggcttca ttcttaatca tattcccatc actcatgctg 480 ttaatacagc ttgattattg taagtccaat gctatagacc attttacctg tgactatttc 540 cccttactac atctttcttg ttcagacact agattcttag agatagtggg tttttcctgt 600 gctgttttta cgttaatgtt cacattgatg ataataattc tgtcctacat atatatcctc 660 agaacaattt tgaagattcc ttctactagt cagaggacaa aggccttttc cacctgttct 720 tcccacatga ttgtcatctc tatctcctat ggcagctgca ttttcatgta tattaaccca 780 gcagcaaaag acagagtgtc tctgagcaag ggagttgctg tgctaaacac ctcggtagcc 840 cccatgctga acccctttat ttacagccta aggaaccagc aagtcaagcg agccttcctg 900 gacagggcaa ggaagattgt atttttctca agcaaatga 939

<210> 2160 <211> 312 <212> PRT <213> Canis familiaris

<400> 2160 Met 1 Arg Asn His Thr Glu Leu Thr Asp Phe Ile Leu Leu Gly Leu Ser 5 10 15 Asp Asp Pro Gln Leu Gln Glu Val Ile Phe Val Phe Leu Leu Ile Thr 20 25 30 Tyr Met Leu Ser Ile Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Leu Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60

Ser Leu Leu Glu Ile Ser Phe Thr Thr Val Ser Ile Pro Lys Page 2414

Phe Leu

069269_0225_SL.TXT

Ser Thr Leu Ile Thr Gly Asp Lys Thr Val Ser Phe Asn Asp Cys Met 85 90 95 Ala Gln Leu Phe Phe Phe Ile Leu Leu Gly Val Thr Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Ile Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Pro Arg Val Cys Ile Leu Leu Val Phe 130 135 140 Ala Ser Trp Ser Ala Ser Phe Leu Ile Ile Phe Pro Ser Leu Met Leu 145 150 155 160 Leu Ile Gln Leu Asp Tyr Cys Lys Ser Asn Ala Ile Asp His Phe Thr 165 170 175 Cys Asp Tyr Phe Pro Leu Leu His Leu Ser Cys Ser Asp Thr Arg Phe 180 185 190 Leu Glu Ile Val Gly Phe Ser Cys Ala Val Phe Thr Leu Met Phe Thr 195 200 205 Leu Met Ile Ile Ile Leu Ser Tyr Ile Tyr Ile Leu Arg Thr Ile Leu 210 215 220 Lys Ile Pro Ser Thr Ser Gln Arg Thr Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Ile Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Asn Pro Ala Ala Lys Asp Arg Val Ser Leu Ser Lys Gly Val 260 265 270 Ala Val Leu Asn Thr Ser Val Ala Pro Met Leu Asn Pro Phe Ile Tyr

Page 2415

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275 280 285 Ser Leu Arg Asn Gln Gln Val Lys Arg Ala Phe Leu Asp Arg Ala Arg 290 295 300 Lys Ile Val Phe Phe Ser Ser Lys 305 310

<210> 2161 <211> 882 <212> DNA <213> Canis familiaris <400> 2161

ccagagtttc agattgtgat ttttctcttt ttaattctca catacatatt cagtgtcact 60 ggaaatttga ccatcatcac tctcaccttg gtggactccc atctacagac ccctatgtat 120 tttttcctca ggaacttctc tgtattagaa atatccttta caaccgtctg tattcctaga 180 tttctgggca caattatcac cagagactaa actatttcat acaatgattg tacagctcag 240 ttgtttttct tcatcttcat gggcataact gagttttatc ttctaactgc tatgtcctat 300 gatcgctatg tagccatctg taaacccttg cattacacga ctatcatgaa caaaagagtc 360 tgcattttac ttgtcttttg tgcatggctg gcaggattct taaatatctt cccgccaatt 420 attcttttcc tccagttaga ttactgtggc tccaatgtca ttgatcactt tgcttgtgac 480 tattttcccc tcttgcaatt atcttgctca gacacatggc tcctagaagt gattggtttt 540 tactctgcaa tagtgattct gcttttcact ctggcactaa taattctatc ctacatgttc 600 atcattagaa caattctgaa actgccatct gccagtcaga gaaaaaaggc attttctaca 660 tgctcctcgc acatgattgt catttccatc tcttatggaa gctgcatatt catgtatgcc 720 aacccctctg caaaagaaaa ggcatccttg accaaaggag tagctattct taatacttct 780 gttgctccta tgatgaatcc atttatatat accctgagga atcagcaagt aaagcaagcc 840 tttaaggata ctatccaaaa ggttctgttt ttctccagta aa 882

<210> 2162 <211> 208 <212> PRT <213> Canis familiaris

Page 2416

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<400> 2162 Ala Met Ser Tyr Asp Arg 15 Met 1 Gly Ile Thr Glu Phe 5 Tyr Leu Leu Thr 10 Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Thr Thr Ile Met Asn Lys 20 25 30 Arg Val Cys Ile Leu Leu Val Phe Cys Ala Trp Leu Ala Gly Phe Leu 35 40 45 Asn Ile Phe Pro Pro Ile Ile Leu Phe Leu Gln Leu Asp Tyr Cys Gly 50 55 60 Ser Asn Val Ile Asp His Phe Ala Cys Asp Tyr Phe Pro Leu Leu Gln 65 70 75 80 Leu Ser Cys Ser Asp Thr Trp Leu Leu Glu Val Ile Gly Phe Tyr Ser 85 90 95 Ala Ile Val Ile Leu Leu Phe Thr Leu Ala Leu Ile Ile Leu Ser Tyr 100 105 110 Met Phe Ile Ile Arg Thr Ile Leu Lys Leu Pro Ser Ala Ser Gln Arg 115 120 125 Lys Lys Ala Phe Ser Thr Cys Ser Ser His Met Ile Val Ile Ser Ile 130 135 140 Ser Tyr Gly Ser Cys Ile Phe Met Tyr Ala Asn Pro Ser Ala Lys Glu 145 150 155 160 Lys Ala Ser Leu Thr Lys Gly Val Ala Ile Leu Asn Thr Ser Val Ala 165 170 175 Pro Met Met Asn Pro Phe Ile Tyr Thr Leu Arg Asn Gln Gln Val Lys 180 185 190 Gln Ala Phe Lys Asp Thr Ile Gln Lys Val Leu Phe Phe Ser Ser Lys 195 200 205

Page 2417

069269_0225_SL.TXT <210> 2163 <211> 327 <212> DNA <213> Canis familiaris <400> 2163 atgcggggac ggaacgccac caaggtcagc gtcttcgtcc tgctgggctt ccccacggcc 60 cctcggctgc agtacgtgct cttcctcgtc ttcctgctca cctacctctt catcctggtg 120 gagaacctcg tcatcatcgt caccgtccgc cgcagcgccc ccctccacag gcccatgtac 180 tacttcctgg gcgccctgtc tgtcctggag gtctggtacg tgtcggtcat catccccaag 240 atgctggggg ggctcctcct gcagcagaaa ctcatctcct ttggcggctg catgacccgg 300 ctctacttca ttggcctgcg cctgtgt

327 <210> 2164 <211> 109 <212> PRT <213> Canis familiaris

<400> 2164 Met Arg Gly Arg Asn Ala Thr Lys Val Ser 1 5 10 Phe Pro Thr Ala Pro Arg Leu Gln Tyr Val 20 25 Leu Thr Tyr Leu Phe Ile Leu Val Glu Asn 35 40 Val Arg Arg Ser Ala Pro Leu His Arg Pro 50 55 Ala Leu Ser Val Leu Glu Val Trp Tyr Val 65 70 Met Leu Gly Gly Leu Leu Leu Gln Gln Lys 85 90

Val Phe Val Leu Leu 15 Gly Leu Phe Leu Val 30 Phe Leu Leu Val Ile 45 Ile Val Thr Met Tyr 60 Tyr Phe Leu Gly Ser 75 Val Ile Ile Pro Lys 80 Leu Ile Ser Phe Gly 95 Gly

Cys Met Thr Arg Leu Tyr Phe Ile Gly Leu Arg Leu Cys Page 2418

100

069269_0225_SL.TXT

105 <210> 2165 <211> 939 <212> DNA <213> Canis familiaris <400> 2165

atgcggggac ggaacgccac caagctcagc gtcttcgtcc tgctgggctt ccccacggcc 60 cctcagctgc agtacgtgct cttcctcgtc ttcctgctca cctacctctt catcctggtg 120 gagaacctcg tcatcatcgt caccgtccgc cgcagcgccc ccctccacag gcccatgtac 180 tacttcctgg gcgccctgtc tgtcctggag gtctggtacg tgtcggtcat catccccaag 240 atgctggggg ggctcctcct gcagcagaaa ctcatctcct ttgccggctg catgacccag 300 ctctacttct tcagctccct ggtgtgcacc gaatgcgtgc tcctggcctc catggcctac 360 gaccgctacg tggccatctg ccaccccctg cgctaccaag tcatcatgac cacggggctc 420 tgcgtccggc tggtggcctt ctccttcgtc agcggcttct ccatctctat gatcaaggtg 480 ttctttgtct ccagggccac cttctgtggc tccaacgtcc tgaaccactt cttctgtgac 540 atttccccca tcctcaagct ggcctgcacc gacttctcga ccgcggagct ggtggacttc 600 atcctggcct tcatcatcct ggtgtcgccc ctggtggcca ccgtgctgtc ctacgggcac 660 atcaccctgg ccgtcctgcg catcccctcg gccacgggcc gctggagggc cttctccacc 720 tgcgcctccc acctcaccgt ggtcaccatc ttctacacgg ccatgatctt catgtacgtc 780 cggccccagg ccatcgattc ccggagctcc aataagctca tctctgcggt gtacactgtc 840 ctcaccccga taatcaaccc cttgatctac tgcctgagga acaaagaatt taaggctgcc 900 ttgaaaaagg ctctgggctt tggtcaagtt cccacatag 939

<210> 2166 <211> 313 <212> PRT <213> Canis familiaris <400> 2166

Leu Cys Gly Asn Leu Thr Lys Ala Gln Ser Leu Phe Gln Gly Ser Leu 1 5 10 15

Page 2419

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Lys Phe Phe Val 20 Pro Gln Ala Val Asp Gln Gly Val Asp Tyr Arg Gly 25 30 Glu Asp Ser Val His Arg Arg Asp Glu Leu Ile Gly Ala Pro Gly Ile 35 40 45 Asp Gly Leu Gly Pro Asp Val His Glu Asp His Gly Arg Val Glu Asp 50 55 60 Gly Asp His Gly Glu Val Gly Gly Ala Gly Gly Glu Gly Pro Pro Ala 65 70 75 80 Ala Arg Gly Arg Gly Asp Ala Gln Asp Gly Gln Gly Asp Val Pro Val 85 90 95 Gly Gln His Gly Gly His Gln Gly Arg His Gln Asp Asp Glu Gly Gln 100 105 110 Asp Glu Val His Gln Leu Arg Gly Arg Glu Val Gly Ala Gly Gln Leu 115 120 125 Glu Asp Gly Gly Asn Val Thr Glu Glu Val Val Gln Asp Val Gly Ala 130 135 140 Thr Glu Gly Gly Pro Gly Asp Lys Glu His Leu Asp His Arg Asp Gly 145 150 155 160 Glu Ala Ala Asp Glu Gly Glu Gly His Gln Pro Asp Ala Glu Pro Arg 165 170 175 Gly His Asp Asp Leu Val Ala Gln Gly Val Ala Asp Gly His Val Ala 180 185 190 Val Val Gly His Gly Gly Gln Glu His Ala Phe Gly Ala His Gln Gly 195 200 205 Ala Glu Glu Val Glu Leu Gly His Ala Ala Gly Lys Gly Asp Glu Phe 210 215 220

Page 2420

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Leu 225 Leu Gln Glu Glu Pro Pro 230 Gln His Leu Gly Asp Asp Asp Arg His 235 240 Val Pro Asp Leu Gln Asp Arg Gln Gly Ala Gln Glu Val Val His Gly 245 250 255 Pro Val Glu Gly Gly Ala Ala Ala Asp Gly Asp Asp Asp Asp Glu Val 260 265 270 Leu His Gln Asp Glu Glu Val Gly Glu Gln Glu Asp Glu Glu Glu His 275 280 285 Val Leu Gln Leu Arg Gly Arg Gly Glu Ala Gln Gln Asp Glu Asp Ala 290 295 300 Glu Leu Gly Gly Val Pro Ser Pro His 305 310

<210> 2167 <211> 942 <212> DNA <213> Canis familiaris <400> 2167

atgaaaatgg gcaaccgaac tgtcatctca gaattcatcc tgctgggcct gcccattgat 60 ccagatcagc gagacctgtt ctacgccctg ttcctggcca tgtacgttac caccatcctg 120 gggaacctac tcatcattgt cctcattcac ctggactcgc acctccacac acccatgtat 180 ttgtttctca gcaatttatc cttctctgac ctctgcttct cttctgtcac aatgcccaag 240 ttgctgcaga acatgcagag ccaagtcccg tccatcccct atgctggctg cctgacccaa 300 atgtacttct tcctgttttt tggagatctg gagagcttcc tcctggtggc catggcctat 360 gaccgctatg tggccatctg cttcccccta cactacacca ccatcatgag ccccaagctc 420 tgtttctccc tgttggtgct gtcatgggtg ctgaccatgt tccatgctgt attacacact 480 ctgttaatgg ccagattgtg tttttgtgcc aacacaatcc cccacttttt ctgtgatatt 540 tctgctctgc tgaagctggc ctgctctgac actcaagtta atgagttggt gatatttatc 600 atgggagggc tcattctcgt gatcccattc ctgctcatca tcacgtctta tgcacggatt 660

Page 2421

069269_0225_SL.TXT gtgtcctcca tcctcaaggt tccttctgcc ataggcatct gcaaggtctt ctccacctgt ggctcccacc tctcagtggt gtctctcttc tatgggacag ttattggtct ctatttatgc ccatcagcta ataattctac tgttaaggag actatcatgg ctatgatgta cactgtggtc acccccatgc tgaacccctt catctacagc ctgaggaata aagacatgaa gggagccctg agaagagtca tttgtagaaa gaaaattacc ttctctgtgt ga

720

780

840

900

942 <210> 2168 <211> 313 <212> PRT <213> Canis familiaris <400> 2168

Met 1 Lys Met Gly Asn Arg Thr Val Ile Ser Glu Phe Ile Leu Leu Gly 5 10 15 Leu Pro Ile Asp Pro Asp Gln Arg Asp Leu Phe Tyr Ala Leu Phe Leu 20 25 30 Ala Met Tyr Val Thr Thr Ile Leu Gly Asn Leu Leu Ile Ile Val Leu 35 40 45 Ile His Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ser Asp Leu Cys Phe Ser Ser Val Thr Met Pro Lys 65 70 75 80 Leu Leu Gln Asn Met Gln Ser Gln Val Pro Ser Ile Pro Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Met Tyr Phe Phe Leu Phe Phe Gly Asp Leu Glu Ser 100 105 110 Phe Leu Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe 115 120 125 Pro Leu His Tyr Thr Thr Ile Met Ser Pro Lys Leu Cys Phe Ser Leu 130 135 140

Page 2422

069269_0225_SL.TXT

Leu Val Leu 145 Ser Trp Val Leu Thr Met Phe His Ala Val Leu His Thr 160 150 155 Leu Leu Met Ala Arg Leu Cys Phe Cys Ala Asn Thr Ile Pro His Phe 165 170 175 Phe Cys Asp Ile Ser Ala Leu Leu Lys Leu Ala Cys Ser Asp Thr Gln 180 185 190 Val Asn Glu Leu Val Ile Phe Ile Met Gly Gly Leu Ile Leu Val Ile 195 200 205 Pro Phe Leu Leu Ile Ile Thr Ser Tyr Ala Arg Ile Val Ser Ser Ile 210 215 220 Leu Lys Val Pro Ser Ala Ile Gly Ile Cys Lys Val Phe Ser Thr Cys 225 230 235 240 Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Val Ile Gly 245 250 255 Leu Tyr Leu Cys Pro Ser Ala Asn Asn Ser Thr Val Lys Glu Thr Ile 260 265 270 Met Ala Met Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Arg Val Ile 290 295 300 Cys Arg Lys Lys Ile Thr Phe Ser Val 305 310 <210> 2169 <211> 939 <212> DNA <213> Canis familiaris <400> 2169 atgcggggac ggaacaccac caaggtcagc gtcttcgtcc tgctgggctt ccccacggcc 60

Page 2423

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cctcggctgc agtacgtgct cttcctcgtc ttcctgctca cctacctctt cattttggtg 120 gagaaccttg tcatcatcgt caccgtccgc cgcagcgccc ccctccacag gcccatgtac 180 tacttcctgg gcgccctgtc tgtcctggag gtctggtacg tgtctgacat cgtccccaag 240 atgctggggg ggctcctcct gcagcagaaa ctcatctcct ttgccggctg catgacccag 300 ctctacttct tcagctccct ggtgtgcacc gaatgcgtgc tcctggcctc catggcctac 360 gaccgctacg tggccatctg ccaccccctg cgctaccaag tcatcatgac cacggggctc 420 tgcgtccggc tggtggcctt ctccttcgtc agcggcttct ccatctctat gatcaaggtg 480 ttctttgtct ccagggccac gttctgtggc tccaacgtcc tgaaccactt cttctgtgac 540 atttccccca tcctcaagct ggcctgcacc gacttctcga ccgcggagct ggtggacttc 600 atcctggcct tcatcatcct ggtgtcgccc ctggtggcca ccgtgctgtc ttacgggcac 660 atcaccctgg ccgtcctgcg catcccctcg gccacgggcc gctggagggc cttctccacc 720 tgcgcctccc acctcaccgt ggtcaccatc ttctacacgg ccatactctt catgtacgtc 780 cggccccagg ccatcgattc ccggagctcc aacaagctca tctctgctct ctacactgtc 840 ctcaccccga taatcaaccc cttgatctac tgcctgagga acaaagaatt taaggctgcc 900 ttgaaaaagg ctctgggctt tggtcaagtt cccacgtag 939

<210> 2170 <211> 313 <212> PRT <213> Canis familiaris <400> 2170

Leu Arg Gly Asn Leu Thr Lys Ala Gln Ser Leu Phe Gln Gly Ser Leu 1 5 10 15 Lys Phe Phe Val Pro Gln Ala Val Asp Gln Gly Val Asp Tyr Arg Gly 20 25 30 Glu Asp Ser Val Glu Ser Arg Asp Glu Leu Val Gly Ala Pro Gly Ile 35 40 45 Asp Gly Leu Gly Pro Asp Val His Glu Glu Tyr Gly Arg Val Glu Asp

50 55 60

Page 2424

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Gly 65 Asp His Gly Glu Val Gly Gly Ala Gly Gly Glu Gly Pro Pro Ala 70 75 80 Ala Arg Gly Arg Gly Asp Ala Gln Asp Gly Gln Gly Asp Val Pro Val 85 90 95 Arg Gln His Gly Gly His Gln Gly Arg His Gln Asp Asp Glu Gly Gln 100 105 110 Asp Glu Val His Gln Leu Arg Gly Arg Glu Val Gly Ala Gly Gln Leu 115 120 125 Glu Asp Gly Gly Asn Val Thr Glu Glu Val Val Gln Asp Val Gly Ala 130 135 140 Thr Glu Arg Gly Pro Gly Asp Lys Glu His Leu Asp His Arg Asp Gly 145 150 155 160 Glu Ala Ala Asp Glu Gly Glu Gly His Gln Pro Asp Ala Glu Pro Arg 165 170 175 Gly His Asp Asp Leu Val Ala Gln Gly Val Ala Asp Gly His Val Ala 180 185 190 Val Val Gly His Gly Gly Gln Glu His Ala Phe Gly Ala His Gln Gly 195 200 205 Ala Glu Glu Val Glu Leu Gly His Ala Ala Gly Lys Gly Asp Glu Phe 210 215 220 Leu Leu Gln Glu Glu Pro Pro Gln His Leu Gly Asp Asp Val Arg His 225 230 235 240 Val Pro Asp Leu Gln Asp Arg Gln Gly Ala Gln Glu Val Val His Gly 245 250 255 Pro Val Glu Gly Gly Ala Ala Ala Asp Gly Asp Asp Asp Asp Lys Val 260 265 270

Page 2425

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Leu His Gln Asn Glu Glu Val Gly Glu Gln Glu Asp Glu Glu Glu His 275 280 285

Val Leu Gln Pro Arg Gly Arg Gly Glu Ala Gln Gln Asp Glu Asp Ala 290 295 300

Asp Leu Gly Gly Val Pro Ser Pro His 305 310 <210> 2171 <211> 243 <212> DNA <213> Canis familiaris <400> 2171

atgaatcaca cagtgatcac caagtttgtc ctgctaggcc tttctgatga tcctgacctt 60 cagattgtga ttttcctctt cttattcgtc acatacttac taagtgtcac tggaaacctg 120 actatcatca ccctaacctt ggtggactct catctacaga cgccaatgta tttcttcctc 180 cgaaacttct ctttcttaga aatcttattt acaactgtat gtattcctag atttctgggg 240 gca 243

<210> 2172 <211> 81 <212> PRT <213> Canis familiaris

<400> 2172 Ile Thr Lys Phe Val Leu Leu Gly Leu Ser Asp Met 1 Asn His Thr Val 5 10 15 Asp Pro Asp Leu Gln Ile Val Ile Phe Leu Phe Leu Phe Val Thr Tyr 20 25 30 Leu Leu Ser Val Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu Val 35 40 45 Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe Ser 50 55 60

Page 2426

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Phe Leu Glu Ile Leu Phe Thr Thr Val Cys Ile Pro Arg Phe Leu Gly 65 70 75 80

Ala <210> 2173 <211> 345 <212> DNA <213> Canis familiaris <400> 2173 atgaggaaag agctgaacag gaattcctca gaagtgactg agttcattct actgggcttc 60 agaacagctt cagacataca gatcctctca ttcttattcc tcttgctggt ctacatggtc 120 atcatagtga gaaatatcag catgataatt gtcatcagga tggactccag acttcatacg 180 cctatgtatt tcttccttag aaacttgtcc tatttagatc tctgctactc cacagtcatt 240 gctcctaaag ctctggctat tttcttgtcc aaggacaaga aaatttcata caatggccat 300 gcagcatagt tcttttcctt tgctgtgatg ggactgaagg ctttc 345 <210> 2174 <211> 102 <212> PRT <213> Canis familiaris <400> 2174

Met Arg Lys Glu Leu Asn Arg Asn Ser Ser Glu Val Thr Glu Phe Ile 1 5 10 15 Leu Leu Gly Phe Arg Thr Ala Ser Asp Ile Gln Ile Leu Ser Phe Leu 20 25 30 Phe Leu Leu Leu Val Tyr Met Val Ile Ile Val Arg Asn Ile Ser Met 35 40 45 Ile Ile Val Ile Arg Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Arg Asn Leu Ser Tyr Leu Asp Leu Cys Tyr Ser Thr Val Ile 65 70 75 80

Page 2427

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Ala Pro Lys Ala Leu Ala Ile Phe Leu Ser Lys Asp Lys Lys Ile Ser 85 90 95

Tyr Asn Gly His Ala Ala 100 <210> 2175 <211> 918 <212> DNA <213> Canis familiaris <400> 2175

atgggtgaca ggggaaccgg caatcactct gacgtgactg actttattct tgtaggcttc 60 agggtctccc ccgaactcta cattctcctc ttcctgctct tcctgcctgt gtatgccatg 120 atcctgctgg ggagtgttgg gatggtggct attatcctga gtgatcccag gctgaacaca 180 ctgatgtatt tcctcctggg caacctctcc ttcattgacc tcttctattc ctctgtaata 240 gcgcccaagg ctatgatcaa cttctggtct gagagcaagt ccatctcctt tgcaggcgtg 300 actcagctct ttctctttgc cctcttcatt gtggctgagg ggtttctcct ggctgccatg 360 gcttatgacc gcttcattgc catctgcaac tcactcctct actctgtcca gatgtcaacg 420 cgcctctgca ttcagttggt ggctggttcc catttttgtg gctgcatcag ctcggttctt 480 caaacgagta tgacatttac tttgtccttt tgtgcttccc gagccatcga ccacttttac 540 tgtgatgacc gtccacttca aaggattact tgctctgatc tctactttca taggatagtt 600 tcctttccct tatgcagcat tattattttg cctaccatca ttgtcattct cgtgtcctat 660 atgtatattg tgtccacagt tctaaagata agatccactg agggatgtaa gaaagccttc 720 tccacttgca gctctcacct aggagtcatg agcgtcctgt acggtgccat cattttaatg 780 tatttcatcc ctgacagatt ccctgagctg agtaaagtag ctccttatgt tatacattag 840 tcactcatgt tgaatccttt gatttactcc ctgagaaaca aagatgtcaa agaggctctg 900 agaaagatcc tggggaaa 918

<210> 2176 <211> 279 <212> PRT

Page 2428

069269_0225_SL.TXT <213> Canis familiaris <400> 2176

Met Gly Asp Arg Gly Thr Gly Asn His Ser Asp Val Thr Asp Phe Ile 1 5 10 15 Leu Val Gly Phe Arg Val Ser Pro Glu Leu Tyr Ile Leu Leu Phe Leu 20 25 30 Leu Phe Leu Pro Val Tyr Ala Met Ile Leu Leu Gly Ser Val Gly Met 35 40 45 Val Ala Ile Ile Leu Ser Asp Pro Arg Leu Asn Thr Leu Met Tyr Phe 50 55 60 Leu Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 65 70 75 80 Ala Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Ser Lys Ser Ile Ser 85 90 95 Phe Ala Gly Val Thr Gln Leu Phe Leu Phe Ala Leu Phe Ile Val Ala 100 105 110 Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile 115 120 125 Cys Asn Ser Leu Leu Tyr Ser Val Gln Met Ser Thr Arg Leu Cys Ile 130 135 140 Gln Leu Val Ala Gly Ser His Phe Cys Gly Cys Ile Ser Ser Val Leu 145 150 155 160 Gln Thr Ser Met Thr Phe Thr Leu Ser Phe Cys Ala Ser Arg Ala Ile 165 170 175 Asp His Phe Tyr Cys Asp Asp Arg Pro Leu Gln Arg Ile Thr Cys Ser 180 185 190 Asp Leu Tyr Phe His Arg Ile Val Ser Phe Pro Leu Cys Ser Ile Ile

Page 2429

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195 200 205 Ile Leu Pro Thr Ile Ile Val Ile Leu Val Ser Tyr Met Tyr Ile Val 210 215 220 Ser Thr Val Leu Lys Ile Arg Ser Thr Glu Gly Cys Lys Lys Ala Phe 225 230 235 240 Ser Thr Cys Ser Ser His Leu Gly Val Met Ser Val Leu Tyr Gly Ala 245 250 255 Ile Ile Leu Met Tyr Phe Ile Pro Asp Arg Phe Pro Glu Leu Ser Lys 260 265 270 Val Ala Pro Tyr Val Ile His 275

<210> 2177 <211> 816 <212> DNA <213> Canis familiaris <400> 2177

gggaactgcc tggtgctgca tgtgatccgg actgagccga gcctgcacca gcccatgttc 60 tacttcctgg ccatgctggc cctcactgac ctgtgcatgg ggctgtccac ggtgcacacg 120 gtgctgggca tcctgtgggg acttagccag gaagtcagcc tggatgcctg cattgctcaa 180 acttatttca tccatggtct gtccctcaca gagtctggag tccttctcgc catggctttg 240 gatcgcttta cagcgatctg taaccctctg aggtatacgt ccatactaac cagtgccagg 300 attaccaaga ttgggctggg aattttagtt aggagttttg tgttcattat ggctcccata 360 atccgcctaa agtttttcca ctattgccat tcccacatac tctcgcactc tttttgcctt 420 caccaagact taccaagact agcatgttct gacattcgct ttaacagttt ctaggccttg 480 gctctggtga tttgcacact tttgtttgat tccatgctaa ttattgtatc ctacattctg 540 atcctgcatt ctgtcttggc tattgcatcc cgggaggagc ggcttaagtc cttgcagacc 600 tgtgtctccc atatctgtgc tgtcatggtt ttctatatcc caataatcgg tctgactatg 660 gtgcatcgtt ttgggaaaca cctctctcct atggtccatg tcctcatggg caacatctat 720

Page 2430

069269_0225_SL.TXT atcatcttcc cacccttgat gaaccccatc atctacagtg tcaaaaccca acaaatccgt ggcaggattc agaagtggtt ttccatgaaa aaggag

780

816 <210> 2178 <211> 157 <212> PRT <213> Canis familiaris <400> 2178

Gly Asn 1 Cys Leu Val 5 Leu His Val Ile Arg Thr Glu Pro Ser Leu His 10 15 Gln Pro Met Phe Tyr Phe Leu Ala Met Leu Ala Leu Thr Asp Leu Cys 20 25 30 Met Gly Leu Ser Thr Val His Thr Val Leu Gly Ile Leu Trp Gly Leu 35 40 45 Ser Gln Glu Val Ser Leu Asp Ala Cys Ile Ala Gln Thr Tyr Phe Ile 50 55 60 His Gly Leu Ser Leu Thr Glu Ser Gly Val Leu Leu Ala Met Ala Leu 65 70 75 80 Asp Arg Phe Thr Ala Ile Cys Asn Pro Leu Arg Tyr Thr Ser Ile Leu 85 90 95 Thr Ser Ala Arg Ile Thr Lys Ile Gly Leu Gly Ile Leu Val Arg Ser 100 105 110 Phe Val Phe Ile Met Ala Pro Ile Ile Arg Leu Lys Phe Phe His Tyr 115 120 125 Cys His Ser His Ile Leu Ser His Ser Phe Cys Leu His Gln Asp Leu 130 135 140 Pro Arg Leu Ala Cys Ser Asp Ile Arg Phe Asn Ser Phe

145 150 155

Page 2431

069269_0225_SL.TXT <210> 2179 <211> 942 <212> DNA <213> Canis familiaris <400> 2179

atgcctgctt ttcctgctta tgacaccaat tcctccacct ttctactaac aggcttccct 60 ggcctggaac aggaatatcc ctggctgtcc atccctttct cctgtatcta ggctatggta 120 ctgtctggga actgcctggt gctgcatgtg atccggactg agccgagcct gcaccagccc 180 atgttctact tcctggccat gctggccctc actgacctgt gcatggggct gtccacggtg 240 cacacggtgc tgggcatcct gtggggactt agccaggaag tcagcctgga tgcctgcatt 300 gctcaaactt atttcatcca tggtctgtcc ctcacagagt ctggagtcct tctcgccatg 360 gctttggatc gctttacagc gatctgtaac cctctgaggt atacgtccat actaaccagt 420 gccaggatta ccaagattgg gctgggaatt ttagttagga gttttgtgtt cattatggct 480 cccataatcc gcctaaagtt tttccactat tgccattccc acatactctc gcactctttt 540 tgccttcacc aagacttact aagactagca tgttctgaca ttcgctttaa cagtttctag 600 gccttggctc tggtgatttg cacacttttg tttgattcca tgctaattat tgtatcctac 660 attctgatcc tgcattctgt cttggctatt gcatcccggg aggagcggct taagtccttg 720 cagacctgtg tctcccatat ctgtgctgtc atggttttct atatcccaat aatcggtctg 780 actatggtgc atcgttttgg gaaacacctc tctcctatgg tccatgtcct catgggcaac 840 atctatatca tcttcccacc cttgatgaac cccatcatct acagtgtcaa aacccaacaa 900 atccgtggca ggattcagaa gtggttttcc atgaaaaagg ag 942

<210> 2180 <211> 101 <212> PRT <213> Canis familiaris <400> 2180

Met Leu Ile Ile Val Ser Tyr Ile Leu Ile Leu His Ser Val Leu Ala 1 5 10 15

Ile Ala Ser Arg Glu Glu Arg Leu Lys Ser Leu Gln Thr Cys Val Ser 20 25 30

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His Ile Cys Ala Val Met Val Phe 35 40 Met Val 50 His Arg Phe Gly Lys 55 His Met 65 Gly Asn Ile Tyr Ile 70 Ile Phe Tyr Ser Val Lys Thr 85 Gln Gln Ile Ser Met Lys Lys 100 Glu

Tyr Ile Pro Ile Ile 45 Gly Leu Thr Leu Ser Pro Met 60 Val His Val Leu Pro Pro Leu 75 Met Asn Pro Ile Ile 80 Arg Gly 90 Arg Ile Gln Lys Trp 95 Phe

<210> 2181 <211> 282 <212> DNA <213> Canis <400> 2181 atgtctgttc ggactggagc ctgtctggga atgttctact tacacggtac familiaris aatctgattc aagaatatcc actgcctggt tcctggccat tgggcatcct caaagtcagt ctggctgtcc gctgcatgtg gctggccctc gtgggggctc aacttcacct atccctttct atccggactg actgacctgt agccaggaga ttctacttac cctgtatcta agccgagcct gcatggggct ta gggattccct tgctatggta gcaccagccc gtccactatg

120

180

240

282 <210> 2182 <211> 94 <212> PRT <213> Canis familiaris

<400> 2182 Met Ser Val Gln Ser Asp Ser Lys Val Ser Asn Phe Thr Phe Leu Leu 1 5 10 15

Thr Gly Phe Pro Gly Leu Glu Gln Glu Tyr Pro Trp Leu Ser Ile Pro 20 25 30

Page 2433

Phe Ser Cys 35 Ile Tyr Ala Met 069269_0225_SL.TXT Val Leu Ser Gly Asn Cys 40 45 Leu Val Leu His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Met 65 70 75 80 Tyr Thr Val Leu Gly Ile Leu Trp Gly Leu Ser Gln Glu Ile 85 90

<210> 2183 <211> 951 <212> DNA <213> Canis familiaris <400> 2183

atgtccaagc tcaatggcac aatcttcatg cccccggtgc tgacactgat tgggatcccc 60 ggcttggagt ctgtgcagtt ctggattgga attcctttct gtgccatgta catcattgct 120 ctgtttggga attccctgct cctggtcatc atcaaatcag aacgcagcct ccatgagccc 180 atgtatctct tcctggcaat gcttggagtc acagacattg ttctcagcac ctgcatccta 240 ccaaaaatgc taggcatctt ctggtttcat ctgcctgaca tatactttga tgcctgtctc 300 tttcagatgt ggcttatcca caccttccaa tccattgaat caggaattct gttcgccatg 360 gccctggacc gctatgtggc catctgtgat cccctgagac acgcatccat ctttacacac 420 aaacttctca ctcagattgg agtgggagtg atgctcagag cagccctcct tgtagctcca 480 tgtctcatcc tcatcaaatg tcggctgaaa cacttccgga ccactgtggt ctcccattca 540 tactgtgagc acatggccat tgtgaagttg gcagcagaag acattcgagt caacaagatc 600 tgtggtctct ttgtggcctt cactctactt ggatttgaca taatcttcat caccctctcc 660 tacatccgaa tatttataac tgtcttcaat ctgcctcaga gggaagctag gctcaaagcc 720 ttcaacacct gcattgccca tatttgcgtc ttccttgagt tttatctcct tggtttcttc 780 tccttcttta cacacaggtt tgggttccat attccaccct acattcatat tcttctgtcc 840 aacctttacc tgcttgtccc tcctttgctc aatcctatag tgtatggggt gaagaccaaa 900

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069269_0225_SL.TXT cagattcgag atcgagtgtc caaggttttc cactctaaag attcatcttg a <210> 2184 <211> 316 <212> PRT <213> Canis familiaris <400> 2184

Met Ser 1 Lys Leu Asn Gly Thr Ile Phe Met Pro Pro Val Leu Thr Leu 5 10 15 Ile Gly Ile Pro Gly Leu Glu Ser Val Gln Phe Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ala Met Tyr Ile Ile Ala Leu Phe Gly Asn Ser Leu Leu Leu 35 40 45 Val Ile Ile Lys Ser Glu Arg Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Gly Val Thr Asp Ile Val Leu Ser Thr Cys Ile Leu 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Leu Pro Asp Ile Tyr Phe 85 90 95 Asp Ala Cys Leu Phe Gln Met Trp Leu Ile His Thr Phe Gln Ser Ile 100 105 110 Glu Ser Gly Ile Leu Phe Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Ala Ser Ile Phe Thr His Lys Leu Leu Thr 130 135 140 Gln Ile Gly Val Gly Val Met Leu Arg Ala Ala Leu Leu Val Ala Pro 145 150 155 160 Cys Leu Ile Leu Ile Lys Cys Arg Leu Lys His Phe Arg Thr Thr Val 165 170 175

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Val Ser His Ser 180 Tyr Cys Glu His Met 185 Ala Ile Val Lys Leu 190 Ala Ala Glu Asp Ile Arg Val Asn Lys Ile Cys Gly Leu Phe Val Ala Phe Thr 195 200 205 Leu Leu Gly Phe Asp Ile Ile Phe Ile Thr Leu Ser Tyr Ile Arg Ile 210 215 220 Phe Ile Thr Val Phe Asn Leu Pro Gln Arg Glu Ala Arg Leu Lys Ala 225 230 235 240 Phe Asn Thr Cys Ile Ala His Ile Cys Val Phe Leu Glu Phe Tyr Leu 245 250 255 Leu Gly Phe Phe Ser Phe Phe Thr His Arg Phe Gly Phe His Ile Pro 260 265 270 Pro Tyr Ile His Ile Leu Leu Ser Asn Leu Tyr Leu Leu Val Pro Pro 275 280 285 Leu Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 Arg Val Ser Lys Val Phe His Ser Lys Asp Ser Ser 305 310 315

<210> 2185 <211> 471 <212> DNA <213> Canis familiaris <400> 2185 atggcagaca atgctacaca tagctacatc tcatcttttt tcctggttgg tattcctggt ttgcaagctt ttcactgctg gattggcatc cctgtctgcc tcctgtttgc cctggccctg ctggggaaca gtgtaatcat catcaccatc aaaatagaac ccagcctcca cctgcctgtg tatttcttcc tttgtatgct ggcagtgaat gacatggctc ttgtctcttc cacagccccc aagatgctgg gtatcttctg gttggatgct cacaagtttg actttagtat ctgtctagca

120

180

240

300

Page 2436

069269_0225_SL.TXT caaatgtatt ttatccacac attctgcata attgagtcag ttcgaccggt atgtagctat ttgtatccca ctgcgttata atggtcacta aaatgggtct agctggtgtg atccgagcta ccctcttggt caaccatctt cctttatggt tgccatggcc gacaacacca ^g

360

420

471 <210> 2186 <211> 157 <212> PRT <213> Canis familiaris

<400> 2186 Met Ala 1 Asp Asn Ala Thr 5 His Ser Tyr Ile 10 Ser Gly Ile Pro Gly Leu Gln Ala Phe His Cys Trp 20 25 Cys Leu Leu Phe Ala Leu Ala Leu Leu Gly Asn 35 40 Thr Ile Lys Ile Glu Pro Ser Leu His Leu Pro 50 55 Cys Met Leu Ala Val Asn Asp Met Ala Leu Val 65 70 75 Lys Met Leu Gly Ile Phe Trp Leu Asp Ala His 85 90 Ile Cys Leu Ala Gln Met Tyr Phe Ile His Thr 100 105 Ser Ala Leu Leu Val Ala Met Ala Phe Asp Arg 115 120 Ile Pro Leu Arg Tyr Thr Thr Ile Leu Thr Thr 130 135 Met Gly Leu Ala Gly Val Ile Arg Ala Thr Phe 145 150 155

Ser Phe Phe Leu Val 15

Ile Gly Ile Pro Val 30

Ser Val Ile Ile Ile 45

Val Tyr Phe Phe Leu 60

Ser Ser Thr Ala Pro 80

Lys Phe Asp Phe Ser 95

Phe Cys Ile Ile Glu 110

Tyr Val Ala Ile Cys 125

Pro Met Val Thr Lys 140

Met Val

Page 2437

069269_0225_SL.TXT <210> 2187 <211> 516 <212> DNA <213> Canis familiaris <400> 2187 atgcctgctt ttcctgctta tgacaccaat tcctccacct ttctactaac aggcttccct 60 ggcctggaac aggaatatcc ctggctgtcc atccctttct cctgtatcta ggctatggta 120 ctgtctggga actgcctggt gctgcatgtg atccggactg agccgagcct gcaccagccc 180 atgttctact tcctggccat gctggccctc actgacctgt gcatggggct gtccacggtg 240 cacacggtgc tgggcatcct gtggggactt agccaggaag tcagcctgga tgcctgcatt 300 gctcaaactt atttcatcca tggtctgtcc ctcacagagt ctggagtcct tctcgccatg 360 gctttggatc gctttacagc gatctgtaac cctctgaggt atacgtccat actaaccagt 420 gccaggatta ccaagattgg gctgggaatt ttagttagga gttttgtgtt cattatggct 480 cccataatcc gcctaaagtt tttccactat tgccat 516 <210> 2188 <211> 134 <212> PRT <213> Canis familiaris <400> 2188

Met 1 Val Leu Ser Gly 5 Asn Cys Leu Val Leu His Val Ile Arg Thr Glu 10 15 Pro Ser Leu His Gln Pro Met Phe Tyr Phe Leu Ala Met Leu Ala Leu 20 25 30 Thr Asp Leu Cys Met Gly Leu Ser Thr Val His Thr Val Leu Gly Ile 35 40 45 Leu Trp Gly Leu Ser Gln Glu Val Ser Leu Asp Ala Cys Ile Ala Gln 50 55 60 Thr Tyr Phe Ile His Gly Leu Ser Leu Thr Glu Ser Gly Val Leu Leu 65 70 75 80

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Ala Met Ala Leu Asp Arg Phe Thr Ala Ile Cys Asn Pro Leu Arg Tyr 85 90 95 Thr Ser Ile Leu Thr Ser Ala Arg Ile Thr Lys Ile Gly Leu Gly Ile 100 105 110 Leu Val Arg Ser Phe Val Phe Ile Met Ala Pro Ile Ile Arg Leu Lys 115 120 125 Phe Phe His Tyr Cys His

130 <210> 2189 <211> 318 <212> DNA <213> Canis familiaris <400> 2189

atgtctgttc aatctgattc caaagtcagt aacttcacct ttctactaac gggattccct 60 ggactggagc aagaatatcc ctggctgtcc atccctttct cccgtatcta tgctatggta 120 ctgtctggga actgcctggt gctgcatgtg atccggactg agccgagcct gcaccagccc 180 atgttctact tcctggccat gctggccctc actgacctgt gcatggggct gtccacagtg 240 cacacggtgc tgggcatcct gtgggggctc agccaggaga tttggatgcc tgcattgcct 300 aaaacttctt tattcatg 318

<210> 2190 <211> 106 <212> PRT <213> Canis familiaris

<400> 2190 Asp Ser Lys Val Ser Asn Phe Thr Phe Leu Leu Met 1 Ser Val Gln Ser 5 10 15 Thr Gly Phe Pro Gly Leu Glu Gln Glu Tyr Pro Trp Leu Ser Ile Pro 20 25 30 Phe Ser Arg Ile Tyr Ala Met Val Leu Ser Gly Asn Cys Leu Val Leu 35 40 45

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His Val 50 Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Val 65 70 75 80 His Thr Val Leu Gly Ile Leu Trp Gly Leu Ser Gln Glu Ile Trp Met 85 90 95 Pro Ala Leu Pro Lys Thr Ser Leu Phe Met 100 105

<210> 2191 <211> 951 <212> DNA <213> Canis familiaris <400> 2191

atgtccaagc tcaatggcac aatcttcatg cccccggtgc tgacactgat tgggatcccc 60 ggcttggagt ctgtgcagtt ctggattgga attcctttct gtgccatgta catcattgct 120 ctatttggga attccctgct cctgatcatc atcaaatcag aacgcagcct ccatgagccc 180 atgtatctct tcctggcaat gctaggagca acagacattg ctctcagcac ctgcatccta 240 ccaaaaatgc taggtatctt ctggtttcat ttgcctgaca tatactttga tgcctgtctc 300 tttcagatgt ggctaatcca caccttccaa ggcagtaaat caggaattct gttcgccatg 360 gccctggacc gctatgtggc catctgtgat cccctgagac atgcaaccat ctttacacac 420 aaacttctca ctcaaattgg agtgggggtg acgctcagag cagccctcct tgtagctcca 480 tgtctcatcc tcatcaaatg tcggctgaaa cacttccgga ccactgtggt ctcccattca 540 tactgtgagc acatggccat tgtgaagttg gcagcagaag acattcgagt caacaagatc 600 tgtggtctct ttgtggcctt cactctactt ggatttgaca taatcttcat caccctctcc 660 tacatccgaa tatttataac tgtcttcaat ctgcctcaga gggaagctag gctcaaagcc 720 ttcaacacct gcattgccca tatttgcgtc ttccttgagt tttatctcct tggtttcttc 780 tccttcttta cacacaggtt tgggttccat attccaccct acattcatat tcttctgtcc 840

Page 2440

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951

069269_0225_SL.TXT aacctttacc tgcttgtccc tcctttgctc aatcctatag tgtatggggt gaagaccaaa cagattcgag atcgagtgtc caaggttttc cactctaaag attcatcttg a <210> 2192 <211> 316 <212> PRT <213> Canis familiaris <400> 2192

Met Ser Lys 1 Leu Asn Gly Thr Ile Phe Met Pro Pro Val Leu Thr Leu 5 10 15 Ile Gly Ile Pro Gly Leu Glu Ser Val Gln Phe Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ala Met Tyr Ile Ile Ala Leu Phe Gly Asn Ser Leu Leu Leu 35 40 45 Ile Ile Ile Lys Ser Glu Arg Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Gly Ala Thr Asp Ile Ala Leu Ser Thr Cys Ile Leu 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Leu Pro Asp Ile Tyr Phe 85 90 95 Asp Ala Cys Leu Phe Gln Met Trp Leu Ile His Thr Phe Gln Gly Ser 100 105 110 Lys Ser Gly Ile Leu Phe Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Ala Thr Ile Phe Thr His Lys Leu Leu Thr 130 135 140 Gln Ile Gly Val Gly Val Thr Leu Arg Ala Ala Leu Leu Val Ala Pro 145 150 155 160 Cys Leu Ile Leu Ile Lys Cys Arg Leu Lys His Phe Arg Thr Thr Val

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Val Ser His Ser 180 Tyr Cys Glu His Glu Asp Ile 195 Arg Val Asn Lys Ile 200 Leu Leu 210 Gly Phe Asp Ile Ile 215 Phe Phe 225 Ile Thr Val Phe Asn 230 Leu Pro Phe Asn Thr Cys Ile 245 Ala His Ile Leu Gly Phe Phe 260 Ser Phe Phe Thr Pro Tyr Ile 275 His Ile Leu Leu Ser 280 Leu Leu 290 Asn Pro Ile Val Tyr 295 Gly Arg 305 Val Ser Lys Val Phe 310 His Ser

6926 9_0225_SL.TXT 170 175 Met 185 Ala Ile Val Lys Leu 190 Ala Ala Cys Gly Leu Phe Val 205 Ala Phe Thr Ile Thr Leu Ser 220 Tyr Ile Arg Ile Gln Arg Glu 235 Ala Arg Leu Lys Ala 240 Cys Val 250 Phe Leu Glu Phe Tyr 255 Leu His 265 Arg Phe Gly Phe His 270 Ile Pro Asn Leu Tyr Leu Leu 285 Val Pro Pro Val Lys Thr Lys 300 Gln Ile Arg Asp Lys Asp Ser 315 Ser

<210> 2193 <211> 945 <212> DNA <213> Canis familiaris <400> 2193 atgcctgctt ttcctgctta tgacaccaat ggcctggaac aggaatatcc ctggctgtcc ctgtctggga actgcctggt gctgcatgtg atgttctact tcctggccac gctggccctc tcctccacct ttctactaac aggcttccct atccctttct cccgtatcta tgctatggta atccggactg agccgagcct gcaccagccc actgacctgt gcatggggct gtccacggtg

120

180

240

Page 2442

069269_0225_SL.TXT cacacggtgc tgggcatcct gtggggactt agccaggaag tcagcctgga tgcctgcatt gctcaaactt atttcatcca tggtctgtcc ctcacagagt ctggagtcct tctcgccatg gctttggatc gctttacagc gatctgtaac cctctgaggt atacgtccat actaaccagt gccaggatta ccaagattgg gctgggaatt ttagttagga gttttgtgtt cattatggct cccataatcc gcctaaagtt tttccactat tgccattccc acatcctctc gcactctttt tgccttcacc aagacttact aagactagca tgttctgaca ttcgctttaa cagtttctat gccttggctc tggtgatttg cacacttttg tttgattcca tgctaattat tgtatcctac attctgatcc tgcattctgt cttggctatt gcatcccggg aggagcggct taagtccttg cagacctgtg tctcccatat ctgtgctgtc atggttttct atatcccaat aatcggtctg actatggtgc atcgttttgg gaaacacctc tctcctatgg tccatgtcct catgggcaac atctatatca tcttcccacc cttgatgaac cccatcatct acagtgtcaa aacccaacaa atccgtggca ggattcagaa gtggttttcc atgaaaaagg agtaa <210> 2194 <211> 314 <212> PRT <213> Canis familiaris <400> 2194

300

360

420

480

540

600

660

720

780

840

900

945

Met Pro Ala Phe Pro Ala Tyr Asp Thr Asn Ser Ser Thr Phe Leu Leu 1 5 10 15 Thr Gly Phe Pro Gly Leu Glu Gln Glu Tyr Pro Trp Leu Ser Ile Pro 20 25 30 Phe Ser Arg Ile Tyr Ala Met Val Leu Ser Gly Asn Cys Leu Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Thr Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Val 65 70 75 80

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His Thr Val Leu Gly 85 Ile Leu Trp Gly Leu Ser Gln Glu Val Ser Leu 90 95 Asp Ala Cys Ile Ala Gln Thr Tyr Phe Ile His Gly Leu Ser Leu Thr 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Leu Asp Arg Phe Thr Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr Ser Ala Arg Ile Thr 130 135 140 Lys Ile Gly Leu Gly Ile Leu Val Arg Ser Phe Val Phe Ile Met Ala 145 150 155 160 Pro Ile Ile Arg Leu Lys Phe Phe His Tyr Cys His Ser His Ile Leu 165 170 175 Ser His Ser Phe Cys Leu His Gln Asp Leu Leu Arg Leu Ala Cys Ser 180 185 190 Asp Ile Arg Phe Asn Ser Phe Tyr Ala Leu Ala Leu Val Ile Cys Thr 195 200 205 Leu Leu Phe Asp Ser Met Leu Ile Ile Val Ser Tyr Ile Leu Ile Leu 210 215 220 His Ser Val Leu Ala Ile Ala Ser Arg Glu Glu Arg Leu Lys Ser Leu 225 230 235 240 Gln Thr Cys Val Ser His Ile Cys Ala Val Met Val Phe Tyr Ile Pro 245 250 255 Ile Ile Gly Leu Thr Met Val His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Met Val His Val Leu Met Gly Asn Ile Tyr Ile Ile Phe Pro Pro Leu 275 280 285

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Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Gln Gln Ile Arg Gly Arg 290 295 300

Ile Gln Lys Trp Phe Ser Met Lys Lys Glu 305 310 <210> 2195 <211> 915 <212> DNA <213> Canis familiaris <400> 2195

atggtgatga atagcactgt gaatgaattc attctgtttg gcttgacaca ggatccaaga 60 aaacagaaag caatatttgg cgtcttcttg atgctttatc ttgccacact gttgggaaat 120 tttctcattg tagtgactat taaaagaagc aggacccttg ggagtcccat gtacttcttc 180 ctattttacc tgtcctttac tgatgcttgc ctctctacaa ccattatccc cagattgatt 240 gtggatgcca tttctcagag gaagaccatt tcctacaatg agtgcatgac tcaggtcttt 300 tcagcccact tctttggatg catggaaatc ttcgtgctga tcgtcatggc ttttgatcgc 360 tatgtagcca tttgtaagcc cttgcgatac acaaccatca tgaacaggca tgtctgcagt 420 gtgctggtga ttctgggttg ggtgggatcc tgtatccact cttcggcaca aattgtcctg 480 gctttgagat tgcctttctg tggtcccaat gtgattgatc actatttctg tgacttgcag 540 cccttgttga aacttgcttg catggacact tatgtaataa atttgctagt tgtttctaac 600 agtggagcca tatgcacggt gagtttcata atcctgctta tctcctatgt tatcatcttg 660 tactctctga gaaactacag tgcagaagga aggcgaaaag ccctttcgac ctgcacctcc 720 cattttattg tggttgtcct attttttggc ccatgtatat tcatatatac acgcccagca 780 accacatttc cagtagacaa ggtggtggct gtattttata ccattggggc acccttgctc 840 aaccctctga tctatacact gaggaatgcg gaagtgaaaa atgccatgaa aaagttatgg 900 tgtaacaaag tgtga 915

<210> 2196 <211> 304 <212> PRT <213> Canis familiaris

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<400> 2196 Ile Leu Phe Gly Leu Thr 15 Met 1 Val Met Asn Ser Thr 5 Val Asn Glu Phe 10 Gln Asp Pro Arg Lys Gln Lys Ala Ile Phe Gly Val Phe Leu Met Leu 20 25 30 Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45 Arg Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Thr Asp Ala Cys Leu Ser Thr Thr Ile Ile Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Ile Ser Gln Arg Lys Thr Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ser Ala His Phe Phe Gly Cys Met Glu Ile Phe Val 100 105 110 Leu Ile Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Asn Arg His Val Cys Ser Val Leu Val Ile 130 135 140 Leu Gly Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Val Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Leu Leu Val Val Ser Asn Ser Gly Ala Ile Cys Thr Val Ser 195 200 205

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Phe Ile 210 Ile Leu Leu Ile Ser Tyr Val Ile Ile Leu Tyr Ser Leu Arg 215 220 Asn Tyr Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser 225 230 235 240 His Phe Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Ala Thr Thr Phe Pro Val Asp Lys Val Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Ala Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Cys Asn Lys Val 290 295 300 <210> 2197 <211> 156 <212> DNA <213> Canis familiaris <400> 2197 atggtgatga atagcactgt gaatgaattc attctgtttg gcttgacaca ggatccaaga aaacagaaag cagtatttgg ggtcttcttg atgttttacc ttgccacact gttgggaaac tttctcattg tagtgactat taaaagaagc aggacc

120

156 <210> 2198 <211> 52 <212> PRT <213> Canis familiaris

<400> 2198 Met Val Met Asn Ser Thr Val Asn Glu Phe Ile Leu Phe Gly Leu Thr 1 5 10 15

Gln Asp Pro Arg Lys Gln Lys Ala Val Phe Gly Val Phe Leu Met Phe 20 25 30

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Tyr Leu Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys 35 40 45

Arg Ser Arg Thr 50 <210> 2199 <211> 924 <212> DNA <213> Canis familiaris <400> 2199

atggagaatc caaaaaatgt gactgaattc atacatttgg gcattacaga gaacccagag 60 ctgcggaaaa tgctctctgc tgtgtttcta atcatgtatg tgttcacggt tttgggaaac 120 ctagtaattg tggtaactgt gatcacaagt caaagtctga gatcacctat gtattttttc 180 cttactttct tatccttttt ggatgttacc tactcttctg tcattgcccc caagatgatt 240 gtggactccc tctccaagag cactgtcacc tccttaaaag gttgcatggc gcagctcctt 300 gcagagcatt tctttggtgg tgtggggatc atcctcctca tcgtgatggc ctatgaccgc 360 tacgtggcca tctgtaagcc cctgcactac tcgaccatca tgagccctca gatgtgctgc 420 ctgctgctgg gaggggcctg ggtgggggga tttatccatg cagcaataca gcttctcttc 480 atgtatcaaa tacccttctg tggccccaat gtcattgatc attttatatg cgatttgttt 540 cccttgttga aactggcctg catggacacc cataccctgg gtctcctagt catcctcaac 600 agtggggtga tgtgtatgac catcttcctt attctcattg cctcctacgt ggtcatcctc 660 tgctctctga agtcttgcag ctctgaaggg cggcgcaaag ccatctccac ctgtggctcc 720 cacctcaccg tggttgtctt gttctttgtg ccatgcattt tcctgtacgt gcggcctgtg 780 gccacctacc ccattgacaa ggcaatggct gtgtctgatt ccatcatcac acccatgtta 840 aatcccttga tctacaccct gaggaattca gaggtgaaaa atgccatgag gaaactgggg 900 aaacaaagga gttttgttgg caag 924

<210> 2200 <211> 308 <212> PRT <213> Canis familiaris

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<400> 2200 Lys Asn Val Thr Glu Phe Ile His Leu Gly Ile 15 Thr Met 1 Glu Asn Pro 5 10 Glu Asn Pro Glu Leu Arg Lys Met Leu Ser Ala Val Phe Leu Ile Met 20 25 30 Tyr Val Phe Thr Val Leu Gly Asn Leu Val Ile Val Val Thr Val Ile 35 40 45 Thr Ser Gln Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Thr Phe Leu 50 55 60 Ser Phe Leu Asp Val Thr Tyr Ser Ser Val Ile Ala Pro Lys Met Ile 65 70 75 80 Val Asp Ser Leu Ser Lys Ser Thr Val Thr Ser Leu Lys Gly Cys Met 85 90 95 Ala Gln Leu Leu Ala Glu His Phe Phe Gly Gly Val Gly Ile Ile Leu 100 105 110 Leu Ile Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Ser Thr Ile Met Ser Pro Gln Met Cys Cys Leu Leu Leu Gly 130 135 140 Gly Ala Trp Val Gly Gly Phe Ile His Ala Ala Ile Gln Leu Leu Phe 145 150 155 160 Met Tyr Gln Ile Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Ile 165 170 175 Cys Asp Leu Phe Pro Leu Leu Lys Leu Ala Cys Met Asp Thr His Thr 180 185 190 Leu Gly Leu Leu Val Ile Leu Asn Ser Gly Val Met Cys Met Thr Ile 195 200 205

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Phe Leu Ile Leu Ile Ala Ser Tyr Val Val Ile Leu Cys Ser Leu Lys 210 215 220 Ser Cys Ser Ser Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys Gly Ser 225 230 235 240 His Leu Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Leu Tyr 245 250 255 Val Arg Pro Val Ala Thr Tyr Pro Ile Asp Lys Ala Met Ala Val Ser 260 265 270 Asp Ser Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Val Lys Asn Ala Met Arg Lys Leu Gly Lys Gln Arg Ser 290 295 300 Phe Val Gly Lys

305

<210> 2201 <211> 933 <212> DNA <213> Canis familiaris <400> 2201 atgcacctga ataataatgt gactgagttc attctgcttg gattgaccca ggatcctgtt 60 agaaaaaaaa tagtgtttgt cacttttttg tttttctatt tggggacatt gctgggtaac 120 tttctgatta ttactactat caagaccagc cagacactag ggagtccaat gtacttcttc 180 cttttccacc tatccttgtc tgacacctgc ttctgtactt ccatagcccc tagaatgatt 240 gttgatgcac ttttgaaaag ggccacaatc tctttcaggg agtgcatgat acaagtcttt 300 tcattccact tctttggctg cctggagatc ttcatcctta tcctcatggc tgctgaccgc 360 tatgtggcca tctgtaagcc cctgcactac acaaccatca tgagtcgaca ggtctgtgct 420 gtgctggtgg ctattgcctg ggtggggtcc tgtgtgcatt ctttagctca gatttttctg 480 gccctgagtt tacctttctg tggtcccaat gtgatcgatc actatcattg tgacttgcag 540

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cccttgttga aacttgcctg tgcagatacc catgtgatca atctactgtt ggtatccaat 600 agtggggcca tttgtacact gagttttgtc atgctgatgt gctcctatgt tgtcatcttg 660 tattctctga gaaatcacag tgctgaaggg aggaggaaag ccctctccac ctgcatctcc 720 cacatcattg tagtcgtctt gttctttggt ccttgcatat ttatatacac acgccctgca 780 accacctttc ccatggataa gatgatagct gtattttata cacttggaac acctttgatc 840 aatcctctga tttacacact taggaatgca gaagtgaaaa atgccatgaa gaagttatgg 900 aggaagaagt tgatttcaga tgacaaaaga tga 933

<210> 2202 <211> 310 <212> PRT <213> Canis familiaris <400> 2202

Met 1 His Leu Asn Asn 5 Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Gln Asp Pro Val Arg Lys Lys Ile Val Phe Val Thr Phe Leu Phe Phe 20 25 30 Tyr Leu Gly Thr Leu Leu Gly Asn Phe Leu Ile Ile Thr Thr Ile Lys 35 40 45 Thr Ser Gln Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe His Leu 50 55 60 Ser Leu Ser Asp Thr Cys Phe Cys Thr Ser Ile Ala Pro Arg Met Ile 65 70 75 80 Val Asp Ala Leu Leu Lys Arg Ala Thr Ile Ser Phe Arg Glu Cys Met 85 90 95 Ile Gln Val Phe Ser Phe His Phe Phe Gly Cys Leu Glu Ile Phe Ile 100 105 110 Leu Ile Leu Met Ala Ala Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125

Page 2451

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His Tyr 130 Thr Thr Ile Met Ser Arg Gln Val Cys Ala Val Leu Val Ala 135 140 Ile Ala Trp Val Gly Ser Cys Val His Ser Leu Ala Gln Ile Phe Leu 145 150 155 160 Ala Leu Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr His 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr His Val 180 185 190 Ile Asn Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Thr Leu Ser 195 200 205 Phe Val Met Leu Met Cys Ser Tyr Val Val Ile Leu Tyr Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ile Ser 225 230 235 240 His Ile Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr 245 250 255 Thr Arg Pro Ala Thr Thr Phe Pro Met Asp Lys Met Ile Ala Val Phe 260 265 270 Tyr Thr Leu Gly Thr Pro Leu Ile Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Lys Lys Leu Trp Arg Lys Lys Leu 290 295 300 Ile Ser Asp Asp Lys Arg

305 310 <210> 2203 <211> 603

Page 2452

069269_0225_SL.TXT <212> DNA <213> Canis familiaris <400> 2203

tttgccttcc ttcttggagc atctgaatgt tacctcctgg ctgtcatgtc ctacgatcgt 60 tatgtcgcca tctgcaagcc cctgcattac acaaccatta tgagcagcaa aatctgtatc 120 cagctagtcc ttagctcttg gatcactggt ttcctcatca tctttccagg actcatttta 180 ggcttaagcc tggacttctg tgattccagt gtcattgatc atttctactg tgacactgct 240 cccctcctgc agatctcctg cacggacaga cacgtgttgg aaatgatgag tttcatctta 300 gctttggtga ctctgctggt cactttggca ttcgtaattc tatcatacac atatattgcc 360 ctgacaattt taaaaattcc ttctaccaac cagagaaaaa agaaaaaagc tttctccacc 420 tgttcttctc acatgattgt catctccctc tcatatggca gctgcatctt tatgtacctt 480 aaaccctcag tcaaacagag gatatccttg atgaagggag tggcagttct caatacttct 540 gttgctccac ttttgaatcc ctttatttat actttaagga aacagcaggt gaagcaagca 600

ttt 603 <210> 2204 <211> 201 <212> PRT <213> Canis familiaris <400> 2204

Phe Ala Phe Leu Leu Gly Ala Ser Glu Cys Tyr Leu Leu Ala Val Met 1 5 10 15 Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Thr Thr 20 25 30 Ile Met Ser Ser Lys Ile Cys Ile Gln Leu Val Leu Ser Ser Trp Ile 35 40 45 Thr Gly Phe Leu Ile Ile Phe Pro Gly Leu Ile Leu Gly Leu Ser Leu 50 55 60 Asp Phe Cys Asp Ser Ser Val Ile Asp His Phe Tyr Cys Asp Thr Ala 65 70 75 80

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Pro Leu Leu Gln Ile Ser Cys Thr Asp Arg His Val Leu Glu Met Met 85 90 95 Ser Phe Ile Leu Ala Leu Val Thr Leu Leu Val Thr Leu Ala Phe Val 100 105 110 Ile Leu Ser Tyr Thr Tyr Ile Ala Leu Thr Ile Leu Lys Ile Pro Ser 115 120 125 Thr Asn Gln Arg Lys Lys Lys Lys Ala Phe Ser Thr Cys Ser Ser His 130 135 140 Met Ile Val Ile Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met Tyr Leu 145 150 155 160 Lys Pro Ser Val Lys Gln Arg Ile Ser Leu Met Lys Gly Val Ala Val 165 170 175 Leu Asn Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr Thr Leu 180 185 190 Arg Lys Gln Gln Val Lys Gln Ala Phe

195 200 <210> 2205 <211> 318 <212> DNA <213> Canis familiaris <400> 2205

atgtctgttc aatctgattc caaagtcagt aacttaaact ttctacttac gggattccct 60 ggactggagc aagaatatcc ctggctgtcc atcccttcct cccgtatcta tgctatggta 120 ctgtctggga actgcctggt gctgcatgtg atccggactg agccgagcct gcaccagccc 180 atgttctact tcctggccat gctggccctc actgacctgt gcatggggct gtccacagtg 240 cacacggtgc tgggcgtcct gtgggggctc agccaggaga tttggatgcc tgcattgcct 300 aaaacttctt tattcatg 318

Page 2454

069269_0225_SL.TXT <210> 2206 <211> 106 <212> PRT <213> Canis familiaris <400> 2206

Met Ser Val Gln Ser Asp Ser Lys Val Ser Asn Leu Asn Phe Leu Leu 1 5 10 15 Thr Gly Phe Pro Gly Leu Glu Gln Glu Tyr Pro Trp Leu Ser Ile Pro 20 25 30 Ser Ser Arg Ile Tyr Ala Met Val Leu Ser Gly Asn Cys Leu Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Val 65 70 75 80 His Thr Val Leu Gly Val Leu Trp Gly Leu Ser Gln Glu Ile Trp Met 85 90 95 Pro Ala Leu Pro Lys Thr Ser Leu Phe Met 100 105

<210> 2207 <211> 189 <212> DNA <213> Canis familiaris <400> 2207 gttttctata tcccaataat cggtctgact atggtgcatc gttttgggaa acacctctct cctatggtcc atgtcctcat gggcaacatc tatatcatct tcccaccctt gatgaacccc atcatctaca gtgtcaaaac ccaacaaatc cgtggcagga ttcagaagtg gttttccatg aaaaaggag

120

180

189 <210> 2208 <211> 63 <212> PRT

Page 2455

069269_0225_SL.TXT <213> Canis familiaris

<400> 2208 Ile Ile Gly Leu Thr Met Val His Arg Phe Gly Val 1 Phe Tyr Ile Pro 5 10 15 Lys His Leu Ser Pro Met Val His Val Leu Met Gly Asn Ile Tyr Ile 20 25 30 Ile Phe Pro Pro Leu Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Gln 35 40 45 Gln Ile Arg Gly Arg Ile Gln Lys Trp Phe Ser Met Lys Lys Glu 50 55 60

<210> 2209 <211> 954 <212> DNA <213> Canis familiaris <400> 2209

atggcagaca atgctacaca tagctacatc tcatcttttt tcctggttgg tattcctggt 60 ttgcaagctt ttcactgctg gattggcatc cctgtctgcc tcctgtttgc cctggccctg 120 ctggggaaca gtgtaatcat catcaccatc aaaatagaac ccagcctcca cctgcctgtg 180 tatttcttcc tttgtatgct ggcagtgaat gacatggctc ttgtctcttc cacagccccc 240 aagatgctgg gtatcttctg gttggatgct cacaagtttg actttagtat ctgtctagca 300 caaatgtatt ttatccacac attctgcata attgagtcag ccctcttggt tgccatggcc 360 ttcgaccggt atgtagctat ttgtatccca ctgcgttata caaccatcgt gacaacacca 420 atgatcacta aaatgggtct agctggtgtg atccgagcta cctttatggt tttgccctgt 480 cctcttctta ttaaaaggct accgtattac actaaatatg ttatcaatca tgcctactgt 540 gagcacatgg ctgtggtgaa gttggccagt gccaacaccc tcattaacag agcatatgga 600 atctctgtgg ccctttcagt gatggtgttg gacctagggc tcatagctac atcctatatc 660 aagatccttc aggcagtctt ccggctatct tctcagaatg cccgctctaa agctctgggc 720 acctgtgctg cccacgtctg cactctactt ggattctaca cacctgcact atttagtttc 780 ctaactcacc gtattggcaa gaaggtacct tcaagcattc atataatctt tgcaagtttg 840

Page 2456

069269_0225_SL.TXT tatcttttgg tgcctcccac agtcaatccc ctggtgtatg gtgtcaagac caaacagatt cgtgaccgtg tggtcagtct cttcctctca aacaagatta tttctggaaa ctaa

900

954 <210> 2210 <211> 317 <212> PRT <213> Canis familiaris <400> 2210

Met Ala 1 Asp Asn Ala Thr His Ser Tyr Ile Ser Ser Phe Phe Leu Val 5 10 15 Gly Ile Pro Gly Leu Gln Ala Phe His Cys Trp Ile Gly Ile Pro Val 20 25 30 Cys Leu Leu Phe Ala Leu Ala Leu Leu Gly Asn Ser Val Ile Ile Ile 35 40 45 Thr Ile Lys Ile Glu Pro Ser Leu His Leu Pro Val Tyr Phe Phe Leu 50 55 60 Cys Met Leu Ala Val Asn Asp Met Ala Leu Val Ser Ser Thr Ala Pro 65 70 75 80 Lys Met Leu Gly Ile Phe Trp Leu Asp Ala His Lys Phe Asp Phe Ser 85 90 95 Ile Cys Leu Ala Gln Met Tyr Phe Ile His Thr Phe Cys Ile Ile Glu 100 105 110 Ser Ala Leu Leu Val Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Ile Pro Leu Arg Tyr Thr Thr Ile Val Thr Thr Pro Met Ile Thr Lys 130 135 140 Met Gly Leu Ala Gly Val Ile Arg Ala Thr Phe Met Val Leu Pro Cys 145 150 155 160

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Pro Leu Leu Ile Lys Arg Leu Pro Tyr Tyr 170 Thr Lys Tyr Val Ile Asn 175 165 His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Ser Ala Asn 180 185 190 Thr Leu Ile Asn Arg Ala Tyr Gly Ile Ser Val Ala Leu Ser Val Met 195 200 205 Val Leu Asp Leu Gly Leu Ile Ala Thr Ser Tyr Ile Lys Ile Leu Gln 210 215 220 Ala Val Phe Arg Leu Ser Ser Gln Asn Ala Arg Ser Lys Ala Leu Gly 225 230 235 240 Thr Cys Ala Ala His Val Cys Thr Leu Leu Gly Phe Tyr Thr Pro Ala 245 250 255 Leu Phe Ser Phe Leu Thr His Arg Ile Gly Lys Lys Val Pro Ser Ser 260 265 270 Ile His Ile Ile Phe Ala Ser Leu Tyr Leu Leu Val Pro Pro Thr Val 275 280 285 Asn Pro Leu Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp Arg Val 290 295 300 Val Ser Leu Phe Leu Ser Asn Lys Ile Ile Ser Gly Asn 305 310 315 <210> 2211 <211> 951 <212> DNA <213> Canis familiaris <400> 2211 atgtccaagc tcaatggcac aatcttcatg cccccggtgc tgacactgat tgggatcccc ggcttggagt ctgtgcagtt ctggattgga attcctttct gtgccatgta catcaatgct ctgtttggga attccctgct cctggtcatc atcaaatcag aacgcagcct ccatgagccc

120

180

Page 2458

069269_0225_S • L.TXT atgtatctct tcctggcaat gcttggagtc acagacattg ttctcagcac ctgcatccta 240 ccaaaaatgc taggcatctt ctggtttcat ctgcctgaca tatactttga tgcctgtctc 300 tttcagatgt ggcttatcca caccttccaa tgcactgaat caggaattct gttggccatg 360 gccctggacc gctatgtggc catctgtgat cccctgagac acgcatccat ctttacacac 420 aaacttctca ctcagattgg agtgggagtg atgctcagag cagccctcct tgtagctcca 480 tgtctcatcc tcatcaaatg tcggctgaaa cacttccgga ccactgtggt ctcccattca 540 tactgtgagc acatggccat tgtgaagttg gcagcagaag acattcgagt caacaagatc 600 tgtggtctct ttgtggcctt cactatactt ggatttgaca taatcttcat caccctctcc 660 tacatccgaa tatttataac tgtcttcaat ctgcctcaga gggaagctag gctcaaagcc 720 ttcaacacct gcattgccca tatttgcgtc ttccttgagt tttatctcct tggtttcttc 780 tccttcttta cacacaggtt tgggttccat attccaccct acattcatat tcttctgtcc 840 aacctttacc tgcttgtccc tcctttgctc aatcctatag tgtatggggt gaagaccaaa 900 cagattcgag atcgagtgtc caaggttttc cactctaaag attcatcttg a 951 <210> 2212 <211> 316 <212> PRT <213> Canis familiaris <400> 2212 Met Ser Lys Leu Asn Gly Thr Ile Phe Met Pro Pro Val Leu Thr Leu 1 5 10 15 Ile Gly Ile Pro Gly Leu Glu Ser Val Gln Phe Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ala Met Tyr Ile Asn Ala Leu Phe Gly Asn Ser Leu Leu Leu 35 40 45 Val Ile Ile Lys Ser Glu Arg Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Gly Val Thr Asp Ile Val Leu Ser Thr Cys Ile Leu 65 70 75 80

Page 2459

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Pro Lys Met Leu Gly 85 Ile Phe Trp Phe His 90 Leu Pro Asp Ile Tyr 95 Phe Asp Ala Cys Leu Phe Gln Met Trp Leu Ile His Thr Phe Gln Cys Thr 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Ala Ser Ile Phe Thr His Lys Leu Leu Thr 130 135 140 Gln Ile Gly Val Gly Val Met Leu Arg Ala Ala Leu Leu Val Ala Pro 145 150 155 160 Cys Leu Ile Leu Ile Lys Cys Arg Leu Lys His Phe Arg Thr Thr Val 165 170 175 Val Ser His Ser Tyr Cys Glu His Met Ala Ile Val Lys Leu Ala Ala 180 185 190 Glu Asp Ile Arg Val Asn Lys Ile Cys Gly Leu Phe Val Ala Phe Thr 195 200 205 Ile Leu Gly Phe Asp Ile Ile Phe Ile Thr Leu Ser Tyr Ile Arg Ile 210 215 220 Phe Ile Thr Val Phe Asn Leu Pro Gln Arg Glu Ala Arg Leu Lys Ala 225 230 235 240 Phe Asn Thr Cys Ile Ala His Ile Cys Val Phe Leu Glu Phe Tyr Leu 245 250 255 Leu Gly Phe Phe Ser Phe Phe Thr His Arg Phe Gly Phe His Ile Pro 260 265 270 Pro Tyr Ile His Ile Leu Leu Ser Asn Leu Tyr Leu Leu Val Pro Pro 275 280 285

Page 2460

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Leu Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300

Arg Val Ser Lys Val Phe His Ser Lys Asp Ser Ser

305 310 315 <210> 2213 <211> 945 <212> DNA <213> Canis familiaris <400> 2213

atgcctgctt ttcctgctta tgacaccaat tcctccacct ttctactaac aggcttccct 60 ggcctggaac aggaatatcc ctggctgtcc atccctttct cctgtatcta tgctatggta 120 ctgtctggga actgcctggt gctgcatgtg atccggactg agccgagcct gcaccagccc 180 atgttctact tcctggccat gctggccctc actgacctgt gcatggggct gtccacggtg 240 cacacggtgc tgggcatcct gtggggactt agccaggaag tcagcctgga tgcctgcatt 300 gctcaaactt atttcatcca tggtctgtcc ctcacagagt ctggagtcct tctcgccatg 360 gctttggatc gctttacagc gatctgtaac cctctgaggt atacgtccat actaaccagt 420 gccaggatta ccaagattgg gctgggaatt ttagttagga gttttgtgtt cattatggct 480 cccataatcc gcctaaagtt tttccactat tgccattccc acatcctctc gcactctttt 540 tgccttcacc aagacttact aagactagca tgttctgaca ttcgctttaa cagtttctat 600 gccttggctc tggtgatttg cacacttttg tttgattcca tgctaattat tgtatcctac 660 attctgatcc tgcattctgt cttggctatt gcatcccggg aggagcggct taagtccttg 720 cagacctgtg tctcccatat ctgtgctgtc atggttttct atatcccaat aatcggtctg 780 actatggtgc atcgttttgg gaaacacctc tctcctatgg tccatgtcct catgggcaac 840 atctatatca tcttcccacc cttgatgaac cccatcatct acagtgtcaa aacccaacaa 900 atccgtggca ggattcagaa gtggttttcc atgaaaaagg agtaa 945

<210> 2214 <211> 314 <212> PRT <213> Canis familiaris

Page 2461

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<400> 2214 Pro Ala Tyr Asp Thr Asn Ser Ser Thr Phe Leu Leu 15 Met 1 Pro Ala Phe 5 10 Thr Gly Phe Pro Gly Leu Glu Gln Glu Tyr Pro Trp Leu Ser Ile Pro 20 25 30 Phe Ser Cys Ile Tyr Ala Met Val Leu Ser Gly Asn Cys Leu Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Val 65 70 75 80 His Thr Val Leu Gly Ile Leu Trp Gly Leu Ser Gln Glu Val Ser Leu 85 90 95 Asp Ala Cys Ile Ala Gln Thr Tyr Phe Ile His Gly Leu Ser Leu Thr 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Leu Asp Arg Phe Thr Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr Ser Ala Arg Ile Thr 130 135 140 Lys Ile Gly Leu Gly Ile Leu Val Arg Ser Phe Val Phe Ile Met Ala 145 150 155 160 Pro Ile Ile Arg Leu Lys Phe Phe His Tyr Cys His Ser His Ile Leu 165 170 175 Ser His Ser Phe Cys Leu His Gln Asp Leu Leu Arg Leu Ala Cys Ser 180 185 190 Asp Ile Arg Phe Asn Ser Phe Tyr Ala Leu Ala Leu Val Ile Cys Thr 195 200 205

Page 2462

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Leu Leu Phe Asp Ser Met Leu Ile Ile Val Ser Tyr Ile Leu Ile Leu 210 215 220 His Ser Val Leu Ala Ile Ala Ser Arg Glu Glu Arg Leu Lys Ser Leu 225 230 235 240 Gln Thr Cys Val Ser His Ile Cys Ala Val Met Val Phe Tyr Ile Pro 245 250 255 Ile Ile Gly Leu Thr Met Val His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Met Val His Val Leu Met Gly Asn Ile Tyr Ile Ile Phe Pro Pro Leu 275 280 285 Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Gln Gln Ile Arg Gly Arg 290 295 300 Ile Gln Lys Trp Phe Ser Met Lys Lys Glu

305 310 <210> 2215 <211> 942 <212> DNA <213> Canis familiaris <400> 2215

atactggctt cagggaacag ctcttcacat cctgtgttct tgatcctact tggaatccca 60 ggactggaga attaccaatt ttggattgcc tttcctctat gtgccatgta tttcgaagct 120 atagttggca atatcattat gccttcatat aatctgaact gaccacaccc tgcttgagcc 180 catgtacctt tttctagcca tgctggctat cactgacctg gctctatcct cttccacgca 240 acctaaaatg ctggctatac tctggtttcg tgctcatgag attgaatacc atgcctgcct 300 catccaggtg ttcttcatcc atgccttttc ctctgtgaag tccaggttgc tcatggctat 360 ggcctggacc attatgtggc tatctgtttc ccactccacc actctacttt cctgacccca 420 gctgtagtgg gtaaactggg agtagctgtg atgatgagag gattgctatg ggtgagcccc 480

Page 2463

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ttctgcatta tggtctccag gatgcccttc tgccccaaac acatcattgc ccagtcatac 540 tgtgagcaca tggctgtgtt aaagctggtg tgtgcagaca ctagagtaaa ccgtgcatat 600 gggctctttg tggccttctc tgtggttggc tttgatataa ttgtcatcag tatatgctat 660 gtgatgattc tgagaactgt tctggggttg ccctctgatg aagccaagtt caaggctttt 720 ggcacatgtg cttcccttat ctgtatcatc ttggcttttt atatcccagc cctctttact 780 ttcctcaccc actgctttgg acaccatgtg ccccgagtgg tacatatcat gttcgccatt 840 ttctatctcc tggtacctcc catgctcaac cccatcatct atggagtcag aaccaagcag 900 atcagggaca gggatattca aggttgttgt ggaaaagatc cc 942

<210> 2216 <211> 164 <212> PRT <213> Canis familiaris

<400> 2216 Leu Trp Val Ser Pro Phe Cys Ile Met Val Ser Met Met 1 Arg Gly Leu 5 10 15 Arg Met Pro Phe Cys Pro Lys His Ile Ile Ala Gln Ser Tyr Cys Glu 20 25 30 His Met Ala Val Leu Lys Leu Val Cys Ala Asp Thr Arg Val Asn Arg 35 40 45 Ala Tyr Gly Leu Phe Val Ala Phe Ser Val Val Gly Phe Asp Ile Ile 50 55 60 Val Ile Ser Ile Cys Tyr Val Met Ile Leu Arg Thr Val Leu Gly Leu 65 70 75 80 Pro Ser Asp Glu Ala Lys Phe Lys Ala Phe Gly Thr Cys Ala Ser Leu 85 90 95 Ile Cys Ile Ile Leu Ala Phe Tyr Ile Pro Ala Leu Phe Thr Phe Leu 100 105 110

Thr His Cys

Phe Gly His His Val

Pro Arg Val Val His Page 2464

Ile Met

Phe

069269_0225_SL.TXT

115 120 125 Ala Ile Phe Tyr Leu Leu Val Pro Pro Met Leu Asn Pro Ile Ile Tyr 130 135 140 Gly Val Arg Thr Lys Gln Ile Arg Asp Arg Asp Ile Gln Gly Cys Cys 145 150 155 160

Gly Lys Asp Pro <210> 2217 <211> 960 <212> DNA <213> Canis familiaris <400> 2217

atggaaaaag ccaactggtc ctcccctgtg gcggggttca ttatcctggg actctcagac 60 cacccagggt tggagaaaat attttttgtg ctcatcctcc tgatgtacct gatgatcctg 120 ctgggcaacg gggtcctcat cctggtgacc atccttgact cccgcctgca cacacccatg 180 tacttcttcc tggggaacct ctccttcctg gacatctgct acacaacctc ctcagtccct 240 ctagtcctgg atggcttcct gacccccagg aaaatcatct ccttctcagc ctgtgctgtg 300 cagatgtttc tctcttttac catgggagcc acagagtgtg tgcttctggg catgatggca 360 tttgatcgct atgtggccat ctgtaacccg ctgaggtacc ctgtggtcat gagcaaggct 420 gcctatgtgc ccatggctgt cagctcctgg gctattggtg gtactgcttc tgtggtacac 480 acatccttga caattcagtt gcctttctgt ggaaacaatg tcatcaatca ccttgcctgt 540 gagatcctgg ctgtcctgag attggcctgt gttgacatct ccatcaatgt catcagcatg 600 ggagtgacaa atgtgatctt cctgggggtc ccagtactct ttatctctat ctcttatgtg 660 ttcatcattg ctaccatcct gaggatcccc tcagctgagg ggaggagaaa ggctttctcc 720 acctgctctg cccacttcac tgtggtggtc atcttctacg ggaccttatt tttcatgtat 780 agaaagccca aatctaagga ttccctggga caaaacaaag aggacctttc agataagctc 840 attcctctct tttatggagt ggtgaccccc atgctcaacc ccatcatcta tagcctcagg 900 aacaaggacg tgaagtctgc tgtgaggaac ctgatgtctc agaagtgctt caccaggtga 960

Page 2465

069269_0225_SL.TXT <210> 2218 <211> 319 <212> PRT <213> Canis familiaris

<400> 2218 Met 1 Glu Lys Ala Asn 5 Trp Ser Ser Pro Val Ala Gly Phe Ile Ile Leu 10 15 Gly Leu Ser Asp His Pro Gly Leu Glu Lys Ile Phe Phe Val Leu Ile 20 25 30 Leu Leu Met Tyr Leu Met Ile Leu Leu Gly Asn Gly Val Leu Ile Leu 35 40 45 Val Thr Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro 65 70 75 80 Leu Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Ile Ile Ser Phe Ser 85 90 95 Ala Cys Ala Val Gln Met Phe Leu Ser Phe Thr Met Gly Ala Thr Glu 100 105 110 Cys Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro 130 135 140 Met Ala Val Ser Ser Trp Ala Ile Gly Gly Thr Ala Ser Val Val His 145 150 155 160 Thr Ser Leu Thr Ile Gln Leu Pro Phe Cys Gly Asn Asn Val Ile Asn 165 170 175

Page 2466

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His Leu Ala Cys Glu Ile Leu Ala Val Leu Arg Leu Ala Cys 190 Val Asp 180 185 Ile Ser Ile Asn Val Ile Ser Met Gly Val Thr Asn Val Ile Phe Leu 195 200 205 Gly Val Pro Val Leu Phe Ile Ser Ile Ser Tyr Val Phe Ile Ile Ala 210 215 220 Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ala His Phe Thr Val Val Val Ile Phe Tyr Gly Thr Leu 245 250 255 Phe Phe Met Tyr Arg Lys Pro Lys Ser Lys Asp Ser Leu Gly Gln Asn 260 265 270 Lys Glu Asp Leu Ser Asp Lys Leu Ile Pro Leu Phe Tyr Gly Val Val 275 280 285 Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val 290 295 300 Lys Ser Ala Val Arg Asn Leu Met Ser Gln Lys Cys Phe Thr Arg 305 310 315 <210> 2219 <211> 960 <212> DNA <213> Canis familiaris <400> 2219 atggaaaaag ccaactggtc ctcccctgtg gcggggttca ttatcctggg actctcagac cacccagggt tggagaaaat attttttgtg ctcatcctcc tgatgtacct gatgatcctg ctgggcaacg gggtcctcat cctggtgacc atccttgact cccgcctgca cacacccatg tacttcttcc tggggaacct ctccttcctg gacatctgct acacaacctc ctcagtccct ctagtcctgg atggcttcct gacccccagg aaaatcatct ccttctcagc ctgtgctgtg

120

180

240

300

Page 2467

069269_0225_SL.TXT

cagatgtttc tctcttttac catgggagcc acagagtgtg tgcttctggg catgatggca 360 tttgatcgct atgtggccat ctgtaacccg ctgaggtacc ctgtggtcat gagcaaggct 420 gcctatgtgc ccatggctgt cagctcctgg gctattggtg gtactgcttc tgtggtacac 480 acatccttga caattcagtt gcctttctgt ggaaacaatg tcatcaatca ccttgcctgt 540 gagatcctgg ctgtcctgag attggcctgt gttgacatct ccatcaatgt catcagcatg 600 ggagtgacaa atgtgatctt cctgggggtc ccagtactct ttatctctat ctcttatgtg 660 ttcatcattg ctaccatcct gaggatcccc tcagctgagg ggaggagaaa ggctttctcc 720 acctgctctg cccacttcac tgtggtggtc atcttctacg ggaccttatt tttcatgtat 780 agaaagccca aatctaagga ttccctggga caaaacaaag aggacctttc agataagctc 840 attcctctct tttatggagt ggtgaccccc atgctcaacc ccatcatcta tagcctcagg 900 aacaaggacg tgaagtctgc tgtgaggaac ctgatgtctc agaagtgctt caccaggtga 960

<210> 2220 <211> 319 <212> PRT <213> Canis familiaris <400> 2220

Met Glu Lys Ala Asn Trp Ser Ser Pro Val Ala Gly Phe Ile Ile Leu 1 5 10 15 Gly Leu Ser Asp His Pro Gly Leu Glu Lys Ile Phe Phe Val Leu Ile 20 25 30 Leu Leu Met Tyr Leu Met Ile Leu Leu Gly Asn Gly Val Leu Ile Leu 35 40 45 Val Thr Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro 65 70 75 80 Leu Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Ile Ile Ser Phe Ser 85 90 95

Page 2468

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Ala Cys Ala Val 100 Gln Met Phe Leu Ser Phe Thr Met Gly Ala Thr Glu 105 110 Cys Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Ala Tyr Val Pro 130 135 140 Met Ala Val Ser Ser Trp Ala Ile Gly Gly Thr Ala Ser Val Val His 145 150 155 160 Thr Ser Leu Thr Ile Gln Leu Pro Phe Cys Gly Asn Asn Val Ile Asn 165 170 175 His Leu Ala Cys Glu Ile Leu Ala Val Leu Arg Leu Ala Cys Val Asp 180 185 190 Ile Ser Ile Asn Val Ile Ser Met Gly Val Thr Asn Val Ile Phe Leu 195 200 205 Gly Val Pro Val Leu Phe Ile Ser Ile Ser Tyr Val Phe Ile Ile Ala 210 215 220 Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ala His Phe Thr Val Val Val Ile Phe Tyr Gly Thr Leu 245 250 255 Phe Phe Met Tyr Arg Lys Pro Lys Ser Lys Asp Ser Leu Gly Gln Asn 260 265 270 Lys Glu Asp Leu Ser Asp Lys Leu Ile Pro Leu Phe Tyr Gly Val Val 275 280 285 Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val 290 295 300

Page 2469

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Lys Ser Ala Val Arg Asn Leu Met Ser Gln Lys Cys Phe Thr Arg 305 310 315 <210> 2221 <211> 708 <212> DNA <213> Canis familiaris <400> 2221

tcattcttga cagcttcgta actcccagga aagccattcc ccttctccac gtctgctgtg 60 cagatgtttc tctcctttgc caagggagcc acagagatta tgctactgag catggtggca 120 tttgatcact atgtggctct gtaacctcct aggtacattg tgttcaaagc aagactgtgt 180 atgtcctcat gtctgccagt ttctggaagg ctgggtgcat gactcccatg gtgcaaacat 240 cctgagcaat gagaaggcct tccatgacta tatcatcaat ccctttatct gtgagatcct 300 ggctgtgctg attttgtcct gtgcggacat ctcatcaatg tgatcggtat ggcagtagcc 360 catgtaatct tcctaggcat tccagttcta tttatttttg tctcttatat gttcatcatt 420 gctaccatcc tgaggatccc ctcagctgaa gggaggataa aggccttctc cacctgctct 480 gcccacctca ctatagtggt cgtcttctat ggaacaatcc tcttcatgta tgggaagccc 540 aaatccaagg atcctcaggg ggcagacaag caggagattt cagacaagct cacctacctc 600 ttctgtgggg tggtgacccc catgctcaac cccatcatct acagcctgag gaacaaggac 660 gtgaaggctg ctgtgaggaa cctagtactt cacaaacact ttatccag 708

<210> 2222 <211> 120 <212> PRT <213> Canis familiaris <400> 2222

Met Ala Val Ala His Val Ile Phe Leu Gly Ile Pro Val Leu Phe Ile 1 5 10 15 Phe Val Ser Tyr Met Phe Ile Ile Ala Thr Ile Leu Arg Ile Pro Ser 20 25 30 Ala Glu Gly Arg Ile Lys Ala Phe Ser Thr Cys Ser Ala His Leu Thr

35 40 45

Page 2470

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Ile Val Val Val Phe Tyr Gly Thr Ile Leu Phe Met Tyr Gly Lys Pro 50 55 60 Lys Ser Lys Asp Pro Gln Gly Ala Asp Lys Gln Glu Ile Ser Asp Lys 65 70 75 80 Leu Thr Tyr Leu Phe Cys Gly Val Val Thr Pro Met Leu Asn Pro Ile 85 90 95 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala Val Arg Asn Leu 100 105 110 Val Leu His Lys His Phe Ile Gln 115 120

<210> 2223 <211> 930 <212> DNA <213> Canis familiaris <400> 2223 atggaaaatc agagcaatgt cacagaattt gttttcatgg gtctgtgggg aaataaacaa gtggagctac tgttctttct cttgttcctg ctctgttatt tggcaatctt aatgggaaac ttcatcatct tactcacgat catccacagc catctaattg aacaaccaat gtactacttt ctctgccacc tttccctcat ggacctctgc tacacctcca ctgtagtccc cagactaatc agggacttag gtgcagccag aaaaaacatt tcctataaca actgtatgac ccagctcttc actgcccact tgctggcagg ggtggagata ttcatcttgg tgtccatggc tttagaccgc tatgttgcca ttgtcaagcc cctgcattac atggtcatca tgaaccggcg gaggtgtaac ctgttgatct tcatggcctg gggtgtgggg ttttggcact ctgttgctct attgctcttg gtactcaatt tacctttctg tggtcctaat cagatagatc attacatatg tgatgtgaag cctcttttga aactggtgtg cagagatatt cgtgttgtta atatcttggt tatttcaaat gcaggaatgg tggtggttgc tgtgtttctt gtcctggtgg cttcttacat tctcatatta tacaatctga agacccactc ctctgtaggg agacgcaaag ctctctccac gtgcagctct

120

180

240

300

360

420

480

540

600

660

720

Page 2471

069269_0225_SL.TXT catgtaatgg tggtcatttt attctttgtg ccttgtatct atatttatgt tctacctgca gggagtgaaa acaaggataa ggagatctct gtgttttaca ctgtgattgc tcccttgttg aatcctctca tctataccct gagaaacgtg gagatgagaa atgccatgtg gaagatgtgg tctaaaatgg cacatacgaa attcaggtaa

780

840

900

930 <210> 2224 <211> 309 <212> PRT <213> Canis familiaris <400> 2224

Met Glu Asn Gln Ser Asn Val Thr Glu Phe Val Phe Met Gly Leu Trp 1 5 10 15

Gly Asn Lys Gln Val Glu Leu Leu Phe Phe Leu Leu Phe Leu Leu Cys 20 25 30

Tyr Leu Ala Ile Leu Met Gly Asn Phe Ile Ile Leu Leu Thr Ile Ile 35 40 45

His Ser His Leu Ile Glu Gln Pro Met Tyr Tyr Phe Leu Cys His Leu 50 55 60

Ser Leu Met Asp Leu Cys Tyr Thr Ser Thr Val Val Pro Arg Leu Ile 65 70 75 80

Arg Asp Leu Gly Ala Ala Arg Lys Asn Ile Ser Tyr Asn Asn Cys Met 85 90 95

Thr Gln Leu Phe Thr Ala His Leu Leu Ala Gly Val Glu Ile Phe Ile 100 105 110

Leu Val Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Val Lys Pro Leu 115 120 125

His Tyr Met Val Ile Met Asn Arg Arg Arg Cys Asn Leu Leu Ile Phe 130 135 140

Met Ala Trp Gly Val Gly Phe Trp His Ser Val Ala Leu Leu Leu Leu Page 2472

0 6926 9_02 25_S L.TX T 145 150 155 160 Val Leu Asn Leu Pro Phe Cys Gly Pro Asn Gln Ile Asp His Tyr Ile 165 170 175 Cys Asp Val Lys Pro Leu Leu Lys Leu Val Cys Arg Asp Ile Arg Val 180 185 190 Val Asn Ile Leu Val Ile Ser Asn Ala Gly Met Val Val Val Ala Val 195 200 205 Phe Leu Val Leu Val Ala Ser Tyr Ile Leu Ile Leu Tyr Asn Leu Lys 210 215 220 Thr His Ser Ser Val Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Val Met Val Val Ile Leu Phe Phe Val Pro Cys Ile Tyr Ile Tyr 245 250 255 Val Leu Pro Ala Gly Ser Glu Asn Lys Asp Lys Glu Ile Ser Val Phe 260 265 270 Tyr Thr Val Ile Ala Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Val Glu Met Arg Asn Ala Met Trp Lys Met Trp Ser Lys Met Ala 290 295 300

His Thr Lys Phe Arg 305 <210> 2225 <211> 912 <212> DNA <213> Canis familiaris <400> 2225 atggagagcc agaggaatgt ctcagaattc attcttttgg gactttcgca tgaccagaac atgcaaatat tttgctttgt gctcttctta ttctgttatg ctgctctctt ggtaggaaac Page 2473

120

069269_0225_SL.TXT

cttctgatcc ttgtctctat tcgatgcagc cctctttttc accaaccaat gtactacttc 180 ctcagccact tatccactct ggacatctgc tatacctcta gcgttacacc caaattaatt 240 gctgacctgc tagtggaaag aaaagccatc tcctatggta attgtatgtt acaggtcttt 300 gccatgcact tctttggaat gattgaagtt ctaatcctta cagtcatggc ctttgatcgc 360 tatgctgcca tctgcaaacc tctccactac ctgcttatca tgaacaggac aaggtgcaat 420 ctcctagtct tagctgcttg ggctggtggg gctgtccact cctttcctca attttgtatg 480 gtaatcaggt tgcccttctg tgggcctaat gagattgatc actatttctg tgatatattt 540 cctttgctaa aggttgcctg cactgatacc tacatcactg gtgtccttat ggttgtcaat 600 tcgggaatgg ttaccttagt gacatttgtg gttttatttt tttcttatgt cattatatta 660 ttcactttaa gaaatcactc agcagaagga agacgcaaag ccctctctac ttgtggatct 720 catatcacgg ttatagtttt attttttggg ccttccatct ttgcctacct tagacctcca 780 actaatttcc ctgaggataa aatatttgct ctgttttaca ccatcattgc tcctatgttc 840 aatcccttaa tctatactct gagaaattca gagatgaaaa atgccatgag aaaattttgg 900 tgtcaaacat ga 912

<210> 2226 <211> 303 <212> PRT <213> Canis familiaris <400> 2226

Met Glu Ser Gln Arg Asn Val Ser Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15 His Asp Gln Asn Met Gln Ile Phe Cys Phe Val Leu Phe Leu Phe Cys 20 25 30 Tyr Ala Ala Leu Leu Val Gly Asn Leu Leu Ile Leu Val Ser Ile Arg 35 40 45 Cys Ser Pro Leu Phe His Gln Pro Met Tyr Tyr Phe Leu Ser His Leu 50 55 60

Page 2474

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Ser Thr 65 Leu Asp Ile Cys Tyr Thr Ser Ser Val Thr Pro Lys Leu Ile 80 70 75 Ala Asp Leu Leu Val Glu Arg Lys Ala Ile Ser Tyr Gly Asn Cys Met 85 90 95 Leu Gln Val Phe Ala Met His Phe Phe Gly Met Ile Glu Val Leu Ile 100 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Leu Ile Met Asn Arg Thr Arg Cys Asn Leu Leu Val Leu 130 135 140 Ala Ala Trp Ala Gly Gly Ala Val His Ser Phe Pro Gln Phe Cys Met 145 150 155 160 Val Ile Arg Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Ile Phe Pro Leu Leu Lys Val Ala Cys Thr Asp Thr Tyr Ile 180 185 190 Thr Gly Val Leu Met Val Val Asn Ser Gly Met Val Thr Leu Val Thr 195 200 205 Phe Val Val Leu Phe Phe Ser Tyr Val Ile Ile Leu Phe Thr Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Ile Thr Val Ile Val Leu Phe Phe Gly Pro Ser Ile Phe Ala Tyr 245 250 255 Leu Arg Pro Pro Thr Asn Phe Pro Glu Asp Lys Ile Phe Ala Leu Phe 260 265 270

Page 2475

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Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285

Asn Ser Glu Met Lys Asn Ala Met Arg Lys Phe Trp Cys Gln Thr 290 295 300 <210> 2227 <211> 213 <212> DNA <213> Canis familiaris <400> 2227 ggtagggtgg tggcagcctt ttctgttgtc ttggtggctt cttacatatt catatcacat aatcttagga cccactcctc cgccgggtaa tgcaaagctc tctccacctg cagctctcat gtaatggtgg tagttttatt cctcatgccc tgtatctgta ctttggttct acctgcaggc agtgaggaca gagatgaaga actctccgta ttt <210> 2228 <211> 40 <212> PRT <213> Canis familiaris

<400> 2228 Val Gly Trp Trp Gln Pro Phe Leu Leu Ser Trp Trp Leu Leu Thr Tyr 1 5 10 15 Ser Tyr His Ile Ile Leu Gly Pro Thr Pro Pro Pro Gly Asn Ala Lys 20 25 30 Leu Ser Pro Pro Ala Ala Leu Met 35 40

<210> 2229 <211> 957 <212> DNA <213> Canis familiaris <400> 2229 atgacagcgc accaaaatgg caccatctcc gttgtggttt ccgacttcct cctgaattgt ttagtcaggt ctcccagctg gaagttctgg ttgtccctgc ccctaagctt cctcttcctc ctggccatgg gggccaatgg tgttctcctg gtcaccatcc agctggaggc ctctctgcat

120

180

213

120

180

Page 2476

069269_0225_SL.TXT

gagcccatgt actacctgct cagcatcctc tctctgctgg acatcgtcct ctgcctgact 240 gttataccca aggtcctggc catcttctgg tttgatctca ggtccatcag cttctctgcc 300 tgcttcattc agatgtacat catgaattgc ttccttggca tggagtcttg aacattcatg 360 gtcatggcct atgaccgcta tgtggccatc tgccacccac tgaggtactc ttccatcatc 420 actgatcaat ttgtagctag ggctgctatg tttattttgg cgaggaatgc acttcttact 480 atgttcattc ctatcctctc tgcccagctc cattattgtg gaaaaaatat aattgagaac 540 tgtatctgtg ccaacctctc tgtgtccaag ctctcctgtg ataatgtttt ccttaacaga 600 atataccagt taactatagc ctggactctt ctgggctctg acctcgtcct catcttcctc 660 tcctacatcc tcatcctaag agccattctt agactgaagg caaaaggggc agctgccaaa 720 gctctgagca catgcggctc tcacttcatt ctcatcctct tctttagcac catcctgctg 780 gtttttgttt ttacccacat ggctaagaaa aaagtttccc ctgatattcc catcttactt 840 aatgtcctac accatgtaat tcctgcagct ctcaatccca ttgtctatgg ggtacgaacc 900 caggagatta aagagggaat taggaagtta ctgagaaggg tagtagagag atgcaag 957 <210> 2230 <211> 200 <212> PRT <213> Canis familiaris <400> 2230 Met Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg 1 5 10 15 Tyr Ser Ser Ile Ile Thr Asp Gln Phe Val Ala Arg Ala Ala Met Phe 20 25 30 Ile Leu Ala Arg Asn Ala Leu Leu Thr Met Phe Ile Pro Ile Leu Ser 35 40 45 Ala Gln Leu His Tyr Cys Gly Lys Asn Ile Ile Glu Asn Cys Ile Cys 50 55 60 Ala Asn Leu Ser Val Ser Lys Leu Ser Cys Asp Asn Val Phe Leu Asn 65 70 75 80

Page 2477

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Arg Ile Tyr Gln Leu Thr Ile Ala Trp Thr Leu Leu Gly Ser Asp Leu 85 90 95 Val Leu Ile Phe Leu Ser Tyr Ile Leu Ile Leu Arg Ala Ile Leu Arg 100 105 110 Leu Lys Ala Lys Gly Ala Ala Ala Lys Ala Leu Ser Thr Cys Gly Ser 115 120 125 His Phe Ile Leu Ile Leu Phe Phe Ser Thr Ile Leu Leu Val Phe Val 130 135 140 Phe Thr His Met Ala Lys Lys Lys Val Ser Pro Asp Ile Pro Ile Leu 145 150 155 160 Leu Asn Val Leu His His Val Ile Pro Ala Ala Leu Asn Pro Ile Val 165 170 175 Tyr Gly Val Arg Thr Gln Glu Ile Lys Glu Gly Ile Arg Lys Leu Leu 180 185 190 Arg Arg Val Val Glu Arg Cys Lys

195 200 <210> 2231 <211> 345 <212> DNA <213> Canis familiaris <400> 2231 atggatctta aaaatggatc tgtagtgact gaatttcttt tactaggatt ttctggatga 60 cgggaacttc agattttctt ctttgtaaca ttctccttaa tctacagtgc tattgtgtgg 120 ggaaatattc tcatgacagt cacagtgaca tttagttcct accttcattc tcccttgtac 180 tttctccttg gaaacctctc tttttctctt ttgggtacgt gtctctccac tgtcaccaca 240 cccaaaatga tcacagactt gcttaaacac aagaccatct ccatatgggg cttcatgact 300 cagatgttct ttatgcactt gtttggggat gctgagatga ctctg 345

Page 2478

069269_0225_SL.TXT <210> 2232 <211> 82 <212> PRT <213> Canis familiaris <400> 2232

Gln Ser His Leu Ser Ile Pro Lys Gln Val His Lys Glu His Leu Ser 1 5 10 15 His Glu Ala Pro Tyr Gly Asp Gly Leu Val Phe Lys Gln Val Cys Asp 20 25 30 His Phe Gly Cys Gly Asp Ser Gly Glu Thr Arg Thr Gln Lys Arg Lys 35 40 45 Arg Glu Val Ser Lys Glu Lys Val Gln Gly Arg Met Lys Val Gly Thr 50 55 60 Lys Cys His Cys Asp Cys His Glu Asn Ile Ser Pro His Asn Ser Thr 65 70 75 80

Val Asp <210> 2233 <211> 753 <212> DNA <213> Canis familiaris <400> 2233

ctatttctca cctacacact gaatgtaact ggaaatctga ccatcatcat actcactttt 60 gtggatcttc accttaaaac acccatgtac cattttttac aaaatgtttc cttcctagag 120 atctcattca caactgcctg tattcccagg tacttgtata acatagcaac aggtaacaag 180 gtcatcacct ataatgcttg tgtcatccaa gtgtttttta ttgacttctt tgctgtgaca 240 gaattttttc tgctggttgc catgtcctat gactgctatg tggccatttg caagcccctg 300 cattatataa ccatcatgag cagcagagtc tgcagaattc atattttttg ctgttggttg 360 gctggattgt tggtcataat cttcccagtt attctggggc taaatctgaa attctatgac 420 tccaatttca ttgatcattc tctctgtgat gctgctcccc tcctgaagat atcatgttcg 480

Page 2479

069269_0225_SL.TXT

gacacatggc ccatggaaca ggctgtttta atctgtgctg tgctgaccct cagtttgacc 540 cttatgtgtg taattctatc ttatattatc aaaacaattt taggatttcc atctattcag 600 cagagaaaaa agagcagaga aaaaagaaaa aaggcctttt ctacctgttc ttcccacatg 660 attgtggttt ccatcaccta tggcacatgc atgttcattt atatgaatcc tacaacaaaa 720 gaagtggcta ttaataaagt ggtttcacta ctg 753

<210> 2234 <211> 251 <212> PRT <213> Canis familiaris

<400> 2234 Thr Tyr 5 Thr Leu Asn Val Thr Gly Asn Leu Thr Ile Ile Leu 1 Phe Leu 10 15 Ile Leu Thr Phe Val Asp Leu His Leu Lys Thr Pro Met Tyr His Phe 20 25 30 Leu Gln Asn Val Ser Phe Leu Glu Ile Ser Phe Thr Thr Ala Cys Ile 35 40 45 Pro Arg Tyr Leu Tyr Asn Ile Ala Thr Gly Asn Lys Val Ile Thr Tyr 50 55 60 Asn Ala Cys Val Ile Gln Val Phe Phe Ile Asp Phe Phe Ala Val Thr 65 70 75 80 Glu Phe Phe Leu Leu Val Ala Met Ser Tyr Asp Cys Tyr Val Ala Ile 85 90 95 Cys Lys Pro Leu His Tyr Ile Thr Ile Met Ser Ser Arg Val Cys Arg 100 105 110 Ile His Ile Phe Cys Cys Trp Leu Ala Gly Leu Leu Val Ile Ile Phe 115 120 125 Pro Val Ile Leu Gly Leu Asn Leu Lys Phe Tyr Asp Ser Asn Phe Ile 130 135 140

Page 2480

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Asp 145 His Ser Leu Cys Asp Ala Ala Pro Leu Leu Lys Ile Ser Cys Ser 150 155 160 Asp Thr Trp Pro Met Glu Gln Ala Val Leu Ile Cys Ala Val Leu Thr 165 170 175 Leu Ser Leu Thr Leu Met Cys Val Ile Leu Ser Tyr Ile Ile Lys Thr 180 185 190 Ile Leu Gly Phe Pro Ser Ile Gln Gln Arg Lys Lys Ser Arg Glu Lys 195 200 205 Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser His Met Ile Val Val Ser 210 215 220 Ile Thr Tyr Gly Thr Cys Met Phe Ile Tyr Met Asn Pro Thr Thr Lys 225 230 235 240 Glu Val Ala Ile Asn Lys Val Val Ser Leu Leu 245 250

<210> 2235 <211> 282 <212> DNA <213> Canis familiaris <400> 2235 tcaactagca cagttatcat ggttgccatc ctgaagatat cttctgctac agggaagaaa aaagccttat ccatgtgctc ctcccacctg acagccatca tcattttcta tgcagtcctt tcatacatgt acttacagcc tcaggctaat aattcccaag aggatatgaa agtgtcttct gtattttacg gcattgtgat ttctcttttg aaccctctga tctatagttt gagaaaaaag gaggtaaaag aagctctaaa aacgatgagg aagaagttct tc

120

180

240

282 <210> 2236 <211> 94 <212> PRT <213> Canis familiaris

Page 2481

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<400> 2236 Val Ile 5 Met Val Ala Ile Leu Lys Ile Ser Ser Ala Ser Thr 1 Ser Thr 10 15 Thr Gly Lys Lys Lys Ala Leu Ser Met Cys Ser Ser His Leu Thr Ala 20 25 30 Ile Ile Ile Phe Tyr Ala Val Leu Ser Tyr Met Tyr Leu Gln Pro Gln 35 40 45 Ala Asn Asn Ser Gln Glu Asp Met Lys Val Ser Ser Val Phe Tyr Gly 50 55 60 Ile Val Ile Ser Leu Leu Asn Pro Leu Ile Tyr Ser Leu Arg Lys Lys 65 70 75 80 Glu Val Lys Glu Ala Leu Lys Thr Met Arg Lys Lys Phe Phe 85 90

<210> 2237 <211> 732 <212> DNA <213> Canis familiaris <400> 2237

ggaaatacta ctatgacagt tactgaattt atcatactag ggtttggaga cctcaaggaa 60 ttgggcccct tgctcttctt ggtgtttggc attgtctacc tagccaccat atctgggaat 120 cttctccttg tggccttggt gagcactcag tggggactcc agacactaat gtacttcttt 180 ctggaaaacc tctcatgcct agaggtctgt tatacatcca acattgtgcc caggatgctg 240 gtgaacttgc tgagaaagaa cagttatctc catgacatgt tgtgtacagt tatctccatg 300 acatgttgtg ttatgcatct ctacttcttt ggggctctgg gcagcactga atgctatctt 360 ctggcagcga tgtcatatga ccgttacctg gctgtctgcc ggcccttgca ctatccaaca 420 ctaatgcatc tagtaattgg ctcgtgggtt agtggcttca cagtaacagc tgcattccag 480 gctgctgtgg taaccagttt gaccttctgt ggtggcaatg agattgacca ttttttctgt 540 gatttgaaac ctctgcagaa gctcttctgc tcagatcccc atctggtcaa cctggtctac 600 atgagtttaa cagtgctggt gactttggcc ccttttggac taaccctaac ttcctactgg 660

Page 2482

069269_0225_SL.TXT aagattcttt ccctggtctt gcatatacct tccatgactg gtaggcagaa ggctttctct acatgttctt ct

720

732 <210> 2238 <211> 244 <212> PRT <213> Canis familiaris <400> 2238

Gly Asn 1 Thr Thr Met Thr Val Thr Glu Phe Ile Ile Leu Gly Phe Gly 5 10 15 Asp Leu Lys Glu Leu Gly Pro Leu Leu Phe Leu Val Phe Gly Ile Val 20 25 30 Tyr Leu Ala Thr Ile Ser Gly Asn Leu Leu Leu Val Ala Leu Val Ser 35 40 45 Thr Gln Trp Gly Leu Gln Thr Leu Met Tyr Phe Phe Leu Glu Asn Leu 50 55 60 Ser Cys Leu Glu Val Cys Tyr Thr Ser Asn Ile Val Pro Arg Met Leu 65 70 75 80 Val Asn Leu Leu Arg Lys Asn Ser Tyr Leu His Asp Met Leu Cys Thr 85 90 95 Val Ile Ser Met Thr Cys Cys Val Met His Leu Tyr Phe Phe Gly Ala 100 105 110 Leu Gly Ser Thr Glu Cys Tyr Leu Leu Ala Ala Met Ser Tyr Asp Arg 115 120 125 Tyr Leu Ala Val Cys Arg Pro Leu His Tyr Pro Thr Leu Met His Leu 130 135 140 Val Ile Gly Ser Trp Val Ser Gly Phe Thr Val Thr Ala Ala Phe Gln 145 150 155 160

Page 2483

Ala Ala Val Val Thr 165 Ser Leu 069269_0225_SL.TXT Thr Phe Cys Gly Gly Asn 170 Glu Ile 175 Asp His Phe Phe Cys Asp Leu Lys Pro Leu Gln Lys Leu Phe Cys Ser Asp 180 185 190 Pro His Leu Val Asn Leu Val Tyr Met Ser Leu Thr Val Leu Val Thr 195 200 205 Leu Ala Pro Phe Gly Leu Thr Leu Thr Ser Tyr Trp Lys Ile Leu Ser 210 215 220 Leu Val Leu His Ile Pro Ser Met Thr Gly Arg Gln Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ser

<210> 2239 <211> 717 <212> DNA <213> Canis familiaris <400> 2239

gaactcagcc tccaaaccct catgcacttc ttttggtcca atctttcctt ccttgagatc 60 tgatatacta cttccattgc ccctaagatg ctgcagaccc tctctcagat tttggggcaa 120 tttcttttgc aggttgtgtg gtccagtttt acttcttcag ttcattactt tagtcgagta 180 gtcgagtgct ttgtgctacc agccatgtct tctgactatc accttgctat ctgcagcccc 240 ctccagtacc catcccttat gaacttctac acatgtagtc tgtttgcagg tgggccttgg 300 ctggatgggt tcctaaccct tgtagtcact gtttccatga ctttctagct gccattccat 360 gcagcctatg agattgacca cttcatccgt gacctggctc ctgtattgaa tctgccctgt 420 tctgatcctg agatggtgga gaaggccact ttcctcctgg cttcctttgt cttggtgcca 480 ggcatgagac tgaatacttg gggattcagg ccactgctgc tccctccttc tagggcactg 540 gccagcagag cagggacctt ccttctgatc ctacagccta aagcccttgg gacctccagg 600 ttagtctttg cctggtaaaa ttgagttttc cagacaaatg caactctatc aggctatacc 660

Page 2484

069269_0225_SL.TXT accatatata aatgcttttt aggggaaaat atgaaagacc caatttacat gctacaa 717 <210> 2240 <211> 59 <212> PRT <213> Canis familiaris

<400> 2240 Pro Ser Cys Thr Ser Phe Gly Pro Ile Phe Pro Asn 1 Ser Ala Ser Lys 5 10 15 Ser Leu Arg Ser Asp Ile Leu Leu Pro Leu Pro Leu Arg Cys Cys Arg 20 25 30 Pro Ser Leu Arg Phe Trp Gly Asn Phe Phe Cys Arg Leu Cys Gly Pro 35 40 45 Val Leu Leu Leu Gln Phe Ile Thr Leu Val Glu 50 55

<210> 2241 <211> 315 <212> DNA <213> Canis familiaris <400> 2241 atggctagca ctgaagaaga aaatataact caaattacag aatttatcct tttgggtttt 60 ggggatctcc atggccttca gtttcttctt tttggggtat ttctggtcat ctatgtggtg 120 actctcatga gcaacattgt aatcctaact gtgtgtcagc tgaccactcc cttcacaccc 180 cccatgtatt tctttcttgg ccacttctcc ttcctagaca ttgggtacac cactaccatt 240 gagcccttga tgctgaggac attcttatca gctcatgtgc ctatttcctt cccaggctgt 300 gcttgccagt tcttt 315 <210> 2242 <211> 105 <212> PRT <213> Canis familiaris <400> 2242

Met Ala Ser Thr Glu Glu Glu Asn Ile Thr Gln Ile Thr Glu Phe Ile 1 5 10 15

Page 2485

069269_0225_SL.TXT

Leu Leu Gly Phe 20 Gly Asp Leu His Gly Leu Gln Phe Leu Leu Phe Gly 25 30 Val Phe Leu Val Ile Tyr Val Val Thr Leu Met Ser Asn Ile Val Ile 35 40 45 Leu Thr Val Cys Gln Leu Thr Thr Pro Phe Thr Pro Pro Met Tyr Phe 50 55 60 Phe Leu Gly His Phe Ser Phe Leu Asp Ile Gly Tyr Thr Thr Thr Ile 65 70 75 80 Glu Pro Leu Met Leu Arg Thr Phe Leu Ser Ala His Val Pro Ile Ser 85 90 95 Phe Pro Gly Cys Ala Cys Gln Phe Phe 100 105

<210> 2243 <211> 924 <212> DNA <213> Canis familiaris <400> 2243 aatgccagca agttgagtga cttcttcctc atgggcctca ctgatgatcc tcagcttcag 60 cctatgttct ttgccctctt cttcttgatc tatgcaatca caatggtggg aaacctgggc 120 ctccttgccc tcattgtggt cagtcctcga ctccacaatc ctatgtattt ctatctatcc 180 tttattgact tttgttattc ttcagacaca gttccaaaaa tgttaatggg tttttttctc 240 tggttgccaa acaatctcct tctctggttg tgtggtacag acaagctgct ttgtgatctt 300 tgctgtcact gagttcttcc tcctggcttc catggcctat gaccactatg tttccatctg 360 caaccctctg ctctatcata tcatcatgtc cccaagattc tgtttgcagt tagtggctgc 420 cagctatgca gtgggcctga tgaatatggt gctcttcaca agtacaacgt tttatctgac 480 cttctgtaaa taacattcat ctctcactat ttctgtgata tccctcccct tttaaaactc 540 tcttgctctg acatgcagat tctccaactt ctcctctttg cctgtggtgg ttttaatgtg 600

Page 2486

069269_0225_SL.TXT tctgtatccc tgataatcat ccttgtctcc tatgcatgtg tcttcttggc tatcatcaga 660 atcccttcag cccagagaaa acacaaaaca ttctccactt gtgcttccca tctgattgct 720 gtcagcctat actatggaac cacagcattc atttactgtg cccatccgct gagtacttac 780 ctgtgcccat ccgctgagta cttactaggc agagacaggc tggtctctgt attctacaca 840 gtggtcatcc ccatgcttaa ccccatgatc tacagtctga ggaataaaga tgtgaaggaa 900 acatttggga atattctgaa gaag 924 <210> 2244 <211> 124 <212> PRT <213> Canis familiaris <400> 2244

Met Gln Ile Leu Gln Leu Leu Leu Phe Ala Cys Gly Gly Phe Asn Val 1 5 10 15

Ser Val Ser Leu Ile Ile Ile Leu Val Ser Tyr Ala Cys Val Phe Leu 20 25 30

Ala Ile Ile Arg Ile Pro Ser Ala Gln Arg Lys His Lys Thr Phe Ser 35 40 45

Thr Cys Ala Ser His Leu Ile Ala Val Ser Leu Tyr Tyr Gly Thr Thr 50 55 60

Ala Phe Ile Tyr Cys Ala His Pro Leu Ser Thr Tyr Leu Cys Pro Ser 65 70 75 80

Ala Glu Tyr Leu Leu Gly Arg Asp Arg Leu Val Ser Val Phe Tyr Thr 85 90 95

Val Val Ile Pro Met Leu Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys 100 105 110

Asp Val Lys Glu Thr Phe Gly Asn Ile Leu Lys Lys 115 120 <210> 2245

Page 2487

069269_0225_SL.TXT <211> 924 <212> DNA <213> Canis familiaris <400> 2245

atggagaatt catctatggt gactgacttc atccttcttg gcatgacaga caaccctcag 60 cttggagtcc tactatttgc agtcttcctt attgtttata ttgtcactgt tttggggaat 120 ctgggcctgg taatcctgat cagagtcagt ccctgcctcc acactcccat gtactttttt 180 ctttctaatc tgtccctact tgatgtctgt ttctcttcca tcacaatccc aaagacttta 240 gcaaatttgt tatctaagtt gcaagctgtt tcttttcttg gatgcatgac tcaaatgggc 300 ttattcataa tatttgcttc tgctgagtgc aaccttttgg cttccatggc ctatgaccgc 360 tatactgcca tctgtcaccc attgctctac tatgtcacca tgtctagagt ccgttgtttc 420 ctcttggtag caggatgcta ctttgggggg ttagttaaca tggtttctgt gacaacttcc 480 atcatacgac tatcattctg tcaaccacat gtccttcccc acttcttctg tgacatccct 540 ccactgttgg cattggcttg ctcagacccc tgggtcaccc aggtactagt tattggctgt 600 gggggattca ccctggtcac ctccattgtg gtgatccttg tctcctacat gtctgtcctc 660 atgacgattc tgggaattcc ttcagcttcc ggaaaacaaa aagctttctc tacatgtgct 720 tcccacatca ccgctgttgg cctgtattat ggaacaacta tgtacactta cttgcagccc 780 tctcaacatg gatcccaggc aggaaatcag atggtttcag tgttttatac aatggtgatc 840 cccatgataa atcctcttat ctacagtttg agaaaccagg aagtgaaagt tgctttatgg 900 aaagtattga agcagagtcc ctaa 924

<210> 2246 <211> 307 <212> PRT <213> Canis familiaris <400> 2246

Met Glu Asn Ser Ser Met Val Thr Asp Phe Ile Leu Leu Gly Met Thr 1 5 10 15 Asp Asn Pro Gln Leu Gly Val Leu Leu Phe Ala Val Phe Leu Ile Val

20 25 30

Page 2488

Tyr Ile Val 35 Thr Val Leu Gly 069269_0225_SL.TXT Asn Leu Gly Leu Val Ile 40 45 Leu Ile Arg Val Ser Pro Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Leu Asp Val Cys Phe Ser Ser Ile Thr Ile Pro Lys Thr Leu 65 70 75 80 Ala Asn Leu Leu Ser Lys Leu Gln Ala Val Ser Phe Leu Gly Cys Met 85 90 95 Thr Gln Met Gly Leu Phe Ile Ile Phe Ala Ser Ala Glu Cys Asn Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys His Pro Leu 115 120 125 Leu Tyr Tyr Val Thr Met Ser Arg Val Arg Cys Phe Leu Leu Val Ala 130 135 140 Gly Cys Tyr Phe Gly Gly Leu Val Asn Met Val Ser Val Thr Thr Ser 145 150 155 160 Ile Ile Arg Leu Ser Phe Cys Gln Pro His Val Leu Pro His Phe Phe 165 170 175 Cys Asp Ile Pro Pro Leu Leu Ala Leu Ala Cys Ser Asp Pro Trp Val 180 185 190 Thr Gln Val Leu Val Ile Gly Cys Gly Gly Phe Thr Leu Val Thr Ser 195 200 205 Ile Val Val Ile Leu Val Ser Tyr Met Ser Val Leu Met Thr Ile Leu 210 215 220 Gly Ile Pro Ser Ala Ser Gly Lys Gln Lys Ala Phe Ser Thr Cys Ala 225 230 235 240

Page 2489

Ser His Ile Thr Ala 245 Val Gly 069269_0225_SL.TXT Leu Tyr Tyr Gly Thr Thr 250 Met Tyr 255 Thr Tyr Leu Gln Pro Ser Gln His Gly Ser Gln Ala Gly Asn Gln Met Val 260 265 270 Ser Val Phe Tyr Thr Met Val Ile Pro Met Ile Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Gln Glu Val Lys Val Ala Leu Trp Lys Val Leu Lys 290 295 300

Gln Ser Pro 305 <210> 2247 <211> 780 <212> DNA <213> Canis familiaris <400> 2247

atgcaccaaa gaaacagaac tatttctaaa ttcttcctcc tgggactcac tgtggggcct 60 gaacatcaga aactcatttt tatgctattt atatgcatgt atctggtcac catggtagga 120 aacttactta ttatcctggc tattatcaat gatgcttacc ttcacagccc catgtacttt 180 tttcttgcca acctatcttt cactgacatc tgcttcacaa ccactacaat ccccaaaatg 240 ttggcagaca tccaaagtca gaacccagcc ctctcttttg cataatgcct tatacaaatg 300 tactttttga tgttgctgtt aaacctggac aatttcctct tggcaaccat ggcatatgac 360 cagtatattg ccatttgtcc cccattacac tatgctgtat tactgaaacc caagcattgt 420 gccttattgg caatgattca atgggtcatc tccaactttg tctcaatgct gcatctcact 480 ctgctgggtc tcttgaccac ctgcgataaa aaaatatccc actttttctg taacctaaaa 540 ctcattttaa gtcttgcttg cacagacact caaatcaatg cattgacaat cctagtcatt 600 gggggagcag ttatcgttat ccctttcacc tttattattg tctcttatgc ctttatttgt 660 tgcactgtac ttggggttcc ttcagctaag gggaagtgga aaacattctc cacttgtggc 720 tctcatcttt tagctgtagc acttttctat ggatccatcg ttggggtcta ctttatcccc 780

Page 2490

069269_0225_SL.TXT <210> 2248 <211> 161 <212> PRT <213> Canis familiaris <400> 2248

Met 1 Tyr Phe Leu Met 5 Leu Leu Leu Asn Leu Asp Asn Phe Leu Leu Ala 10 15 Thr Met Ala Tyr Asp Gln Tyr Ile Ala Ile Cys Pro Pro Leu His Tyr 20 25 30 Ala Val Leu Leu Lys Pro Lys His Cys Ala Leu Leu Ala Met Ile Gln 35 40 45 Trp Val Ile Ser Asn Phe Val Ser Met Leu His Leu Thr Leu Leu Gly 50 55 60 Leu Leu Thr Thr Cys Asp Lys Lys Ile Ser His Phe Phe Cys Asn Leu 65 70 75 80 Lys Leu Ile Leu Ser Leu Ala Cys Thr Asp Thr Gln Ile Asn Ala Leu 85 90 95 Thr Ile Leu Val Ile Gly Gly Ala Val Ile Val Ile Pro Phe Thr Phe 100 105 110 Ile Ile Val Ser Tyr Ala Phe Ile Cys Cys Thr Val Leu Gly Val Pro 115 120 125 Ser Ala Lys Gly Lys Trp Lys Thr Phe Ser Thr Cys Gly Ser His Leu 130 135 140 Leu Ala Val Ala Leu Phe Tyr Gly Ser Ile Val Gly Val Tyr Phe Ile 145 150 155 160

Pro <210> 2249

Page 2491

069269_0225_SL.TXT <211> 801 <212> DNA <213> Canis familiaris <400> 2249 ggaatggact taatcatctt tcttatctac tttgacctcc acctccacac tccaatgtac 60 ttcttcctta ctaatctgtc tttcttagat ctttgctatg gaagcacttc catgccccag 120 gccttagtgc attgtttctc tacccatccc tacctctctt acccaggatg tttgacccaa 180 atgagtgtct ccttggtctt ggccacagca gagtgcctcc tactggctgt catggcctat 240 gaccatatgg ctgctatcag caatcccctg cgctattctg tgatcatgaa tgccccagtg 300 tgtgtctggc tggctactac tttgtggggg gaatcacttg tgctcactgc catgctcgtc 360 ttatccctgc agcttcactt ctatggagtt aatatcatca accattttgt ctgtgaaatt 420 ctttccctcc ttaagctggc ctgttctgat actaatctca atgagcttat gatctccacc 480 acaggtatct tcactctgct cctacccttt ggatttgttc ttctttccta tgcccaaatt 540 gccactactg tcttagagat tctctcagcc cagggtaggc tcaaggcctt ttccacctgt 600 ggctctcatt tgactgtggt gacagtcttc taaggggcaa ccatttccat gtatatgaaa 660 cctcagtcca agtcatctgc tgagcagaac aagtttattt cagtgtttta tggggctttg 720 acacccatgt tgaacccctt aatatatagc ctgaggaaca aggatgttag aggggcaatg 780 aggaaagtta ttgcaaaaag g 801 <210> 2250 <211> 210 <212> PRT <213> Canis familiaris <400> 2250

Gly 1 Met Asp Leu Ile 5 Ile Phe Leu Ile Tyr Phe 10 Asp Leu His Leu 15 His Thr Pro Met Tyr Phe Phe Leu Thr Asn Leu Ser Phe Leu Asp Leu Cys 20 25 30 Tyr Gly Ser Thr Ser Met Pro Gln Ala Leu Val His Cys Phe Ser Thr 35 40 45

Page 2492

His Pro 50 Tyr Leu Ser Tyr Pro 55 069269_0225_SL.TXT Ser Val Ser Gly Cys Leu Thr Gln Met 60 Leu Val Leu Ala Thr Ala Glu Cys Leu Leu Leu Ala Val Met Ala Tyr 65 70 75 80 Asp His Met Ala Ala Ile Ser Asn Pro Leu Arg Tyr Ser Val Ile Met 85 90 95 Asn Ala Pro Val Cys Val Trp Leu Ala Thr Thr Leu Trp Gly Glu Ser 100 105 110 Leu Val Leu Thr Ala Met Leu Val Leu Ser Leu Gln Leu His Phe Tyr 115 120 125 Gly Val Asn Ile Ile Asn His Phe Val Cys Glu Ile Leu Ser Leu Leu 130 135 140 Lys Leu Ala Cys Ser Asp Thr Asn Leu Asn Glu Leu Met Ile Ser Thr 145 150 155 160 Thr Gly Ile Phe Thr Leu Leu Leu Pro Phe Gly Phe Val Leu Leu Ser 165 170 175 Tyr Ala Gln Ile Ala Thr Thr Val Leu Glu Ile Leu Ser Ala Gln Gly 180 185 190 Arg Leu Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Thr 195 200 205

Val Phe 210 <210> 2251 <211> 678 <212> DNA <213> Canis familiaris <400> 2251 tcaatggttt aaaagactac cccaccattt cctatactaa ctgttatgct cagatgatca

Page 2493

069269_0225_SL.TXT ttgctctctt tctggggatg acagtgtctg ctccttgttg tcatggctta tgatagattc 120 attacaattt ctaatcccct gcgttacacc atcattatga acaaccaggt ctgcatacat 180 ttggccatgg tgacctgggc cactgccttc cttttagtaa taataccaat cattgcaatt 240 cctgcccatt tttgtggaca caatgtcatc aatcatttta cctgtgaggt ccaggctctg 300 tcaaggttca cttgctcaga cagcccagtc agacttattc tgggtctagt cattggcatc 360 ttcacactgc ctctgccttt caccttcatt ctcatctcct atactcacat tgtggttgct 420 atgctaagga tccactgtgc agaagccagg ctcaaaactt tctccacctg tgggtcccac 480 ctgactgtgg tcaccatatt ttatggaaca gctatctaca tgtacctgaa acctcagtca 540 agagaatctc agggccaggg tgaagtcatc tctgggattt tatggcattg taacccctat 600 gttgaacccc ctcatttaca ccttcagaaa caaagatgtg aaaaatgctc taagagaaat 660 gacaaggaag aaagaacc 678 <210> 2252 <211> 192 <212> PRT <213> Canis familiaris <400> 2252 Met Ala Tyr Asp Arg Phe Ile Thr Ile Ser Asn Pro Leu Arg Tyr Thr 1 5 10 15 Ile Ile Met Asn Asn Gln Val Cys Ile His Leu Ala Met Val Thr Trp 20 25 30 Ala Thr Ala Phe Leu Leu Val Ile Ile Pro Ile Ile Ala Ile Pro Ala 35 40 45 His Phe Cys Gly His Asn Val Ile Asn His Phe Thr Cys Glu Val Gln 50 55 60 Ala Leu Ser Arg Phe Thr Cys Ser Asp Ser Pro Val Arg Leu Ile Leu 65 70 75 80 Gly Leu Val Ile Gly Ile Phe Thr Leu Pro Leu Pro Phe Thr Phe Ile 85 90 95

Page 2494

069269_0225_SL.TXT

Leu Ile Ser Tyr 100 Thr His Ile Val Val Ala Met Leu Arg Ile His Cys 105 110 Ala Glu Ala Arg Leu Lys Thr Phe Ser Thr Cys Gly Ser His Leu Thr 115 120 125 Val Val Thr Ile Phe Tyr Gly Thr Ala Ile Tyr Met Tyr Leu Lys Pro 130 135 140 Gln Ser Arg Glu Ser Gln Gly Gln Gly Glu Val Ile Ser Gly Ile Leu 145 150 155 160 Trp His Cys Asn Pro Tyr Val Glu Pro Pro His Leu His Leu Gln Lys 165 170 175 Gln Arg Cys Glu Lys Cys Ser Lys Arg Asn Asp Lys Glu Glu Arg Thr 180 185 190

<210> 2253 <211> 741 <212> DNA <213> Canis familiaris <400> 2253

tttttcctca gtaatttatc cttccttggt atctgttact ctatcagctg ggaaacatat 60 gtcttggccc aatgtttcag ggacttcccc atcattttct acaccagctg ttaggcccag 120 atgaccacat ccctctttcc agggatgaca gaatgcctct tccttgctgt catggtttat 180 gacaggtttg ttgctaactc caatcccctg catcacacca cctttatgaa taatcaggtt 240 tgcatacagt tggcattggg aacctgggcc agtgcctttt tagtagcagt cttgccaatc 300 attgcaattc ctgcttatta ttatggacag aatatcatca accattttac ctgtgagatt 360 caggccctgc tgaagttcat ctgctcagac actcctgtca gtctgagtct aggtctggtt 420 atccgtatat tcacactgtc cctgaccttc ccttttgtcc ttatttccta cttctacatt 480 gtagttatca tgctgaggat ccattctgtt ccggccaggc tcaaaccttt ctccacctgt 540 gtcacccatc taactgtagt caccatattt aatggcaaag ccatctacat gtacctgaaa 600 ctacagtcaa aggaatctca ggaagaatac aaattattct agatatttta tggagcagtt 660

Page 2495

069269_0225_SL.TXT attcccacat taattcccct catttacact ctgagaaaca aggacgtaaa atctacactt 720 aggaagttag ccaaagaaaa c 741 <210> 2254 <211> 40 <212> PRT <213> Canis familiaris <400> 2254

Phe Ser Ser Val Ile Tyr Pro Ser Leu Val Ser Val Thr Leu Ser Ala 1 5 10 15 Gly Lys His Met Ser Trp Pro Asn Val Ser Gly Thr Ser Pro Ser Phe 20 25 30 Ser Thr Pro Ala Val Arg Pro Arg

35 40 <210> 2255 <211> 963 <212> DNA <213> Canis familiaris <400> 2255 atggccctat tgcaggcaaa ccacaccttg aactctgagt ttatcatctt gggctttggg 60 gacctggccg aactgcaagt cttctttttt ggactcttcc taatcatgca tcttgtcacc 120 ctagcagggc acacaaccat tgtgctcatc accctcattg actcctgcct ccagaccccc 180 atgtatttct tccttcgcaa cctgtcaacc attgagattt gctatatatt ggtgattgtc 240 cccaacatgc tggccaattt cctatccagg agccagcgga tgcccttcct gggctgtgcc 300 ttgcagatgc acctcttcat cgccctgggt ggtgcagagt gtttcctctt ggccgtgatg 360 gcctatgatc gttttgtagc catctgcaac ccgctgcgct acacagtcat catcactagg 420 gccctctgcc tgcagatgct gactctggca tgcatcagtg gctttacact ctcactcacc 480 cttactacgc tgatattcct tctgcccttt tgtcggtccc acgagatcaa tcatttcttc 540 tgtgacatcc ctgctgtgct gtttctggcc tgctcggaca caagagccaa tgagattgcg 600 gtcttcctcg tctgcatgct cattctgttg attcctttct tgctgattct gctctcctat 660

Page 2496

069269_0225_SL.TXT gcgttcatta ttgctgccat cctcagaatc cactcagctg agggaaggag caaagccttc tccacctgtg ctgggcacct gctggtctct gttctgcact atggctgcgc aatattcatc tacattcgcc ccaagtcatg ctacacccca gaacaggaca aagttgtgtc cttaatctat accaacgtaa ctcccatgct ctaccctatg atctacagtc tgaggaacaa ggaagtcaag ggtgccctca gaagacttct ggagagctat agccagatga ggcagctacc caatgcaagg tga

720

780

840

900

960

963 <210> 2256 <211> 320 <212> PRT <213> Canis familiaris <400> 2256

Met 1 Ala Leu Leu Gln 5 Ala Asn His Thr Leu Asn Ser Glu Phe Ile Ile 10 15 Leu Gly Phe Gly Asp Leu Ala Glu Leu Gln Val Phe Phe Phe Gly Leu 20 25 30 Phe Leu Ile Met His Leu Val Thr Leu Ala Gly His Thr Thr Ile Val 35 40 45 Leu Ile Thr Leu Ile Asp Ser Cys Leu Gln Thr Pro Met Tyr Phe Phe 50 55 60 Leu Arg Asn Leu Ser Thr Ile Glu Ile Cys Tyr Ile Leu Val Ile Val 65 70 75 80 Pro Asn Met Leu Ala Asn Phe Leu Ser Arg Ser Gln Arg Met Pro Phe 85 90 95 Leu Gly Cys Ala Leu Gln Met His Leu Phe Ile Ala Leu Gly Gly Ala 100 105 110 Glu Cys Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Thr Val Ile Ile Thr Arg Ala Leu Cys Leu

Page 2497

069269_0225_SL.TXT

130 135 140

Gln Met 145 Leu Thr Leu Ala 150 Cys Ile Ser Gly Phe Thr Leu Ser Leu Thr 155 160 Leu Thr Thr Leu Ile Phe Leu Leu Pro Phe Cys Arg Ser His Glu Ile 165 170 175 Asn His Phe Phe Cys Asp Ile Pro Ala Val Leu Phe Leu Ala Cys Ser 180 185 190 Asp Thr Arg Ala Asn Glu Ile Ala Val Phe Leu Val Cys Met Leu Ile 195 200 205 Leu Leu Ile Pro Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Ile 210 215 220 Ala Ala Ile Leu Arg Ile His Ser Ala Glu Gly Arg Ser Lys Ala Phe 225 230 235 240 Ser Thr Cys Ala Gly His Leu Leu Val Ser Val Leu His Tyr Gly Cys 245 250 255 Ala Ile Phe Ile Tyr Ile Arg Pro Lys Ser Cys Tyr Thr Pro Glu Gln 260 265 270 Asp Lys Val Val Ser Leu Ile Tyr Thr Asn Val Thr Pro Met Leu Tyr 275 280 285 Pro Met Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Leu Arg 290 295 300 Arg Leu Leu Glu Ser Tyr Ser Gln Met Arg Gln Leu Pro Asn Ala Arg 305 310 315 320

<210> 2257 <211> 867 <212> DNA <213> Canis familiaris

Page 2498

069269_0225_SL.TXT <400> 2257

ctgagacacc caggtgtcct gactgaattc attcttgtgg ggctgtccaa gcaccccaca 60 tcccatactg ttctctcctg ggcagtgatg tttctctaca tagtaacttt ggcaggaaac 120 agtatgatca ttttccaggt aggagtcaat tctcggctcc acatgccaat gtatttcttt 180 ctcagcaact tctctttact gaatgtcctg ttttccacca gtgctgtacc atgttttcca 240 ccagtgctgt accactggtt agccaactct ctgcagaact ttcccaccat ttcctacagt 300 tcctgttttg cccagctcac catctgagcc ttcttggtgc tgattgaata tttccttctt 360 gacattatgg cttatgacag atttgtggct atctcagatc cactcaggta caacctgatc 420 atgtcttctc gagtatgcat ctcaatgtct ttgcttgcat ggataatgtc tttcttgctc 480 actattatgc ccattatgct ctttcccatc agtttttgtg ggcataagtc agtcaatcac 540 ttctcctgtg aagtccaagc catttttatg agactgacat gctgtctacc acgctaagga 600 ggcaggttcc aagccatctt taaattgctc tgttccaaca ccattttcct agagattatg 660 atgatggtgt gcattgtcat ttcaatgcca ggccctttaa ttctcatcct tatctcttac 720 ctttgtatct gcagggtggt ctgaaggacc cacctaactg aggccaggct tgaagttttt 780 tccacatctg gaaaaaactc accttgtcat ggtcaccatc tactttggaa ctctaatata 840 tatttatgtg agactccaaa ccaaaaa 867

<210> 2258 <211> 108 <212> PRT <213> Canis familiaris <400> 2258

Leu Arg His Pro Gly Val Leu Thr Glu Phe Ile Leu Val Gly Leu Ser 1 5 10 15 Lys His Pro Thr Ser His Thr Val Leu Ser Trp Ala Val Met Phe Leu 20 25 30 Tyr Ile Val Thr Leu Ala Gly Asn Ser Met Ile Ile Phe Gln Val Gly 35 40 45 Val Asn Ser Arg Leu His Met Pro Met Tyr Phe Phe Leu Ser Asn Phe

Page 2499

069269_0225_SL.TXT

Ser 65 Leu Leu Asn Val Leu 70 Phe Ser Thr Ser Ala Val Pro Cys 75 Phe Pro 80 Pro Val Leu Tyr His Trp Leu Ala Asn Ser Leu Gln Asn Phe Pro Thr 85 90 95 Ile Ser Tyr Ser Ser Cys Phe Ala Gln Leu Thr Ile 100 105

<210> 2259 <211> 939 <212> DNA <213> Canis familiaris <400> 2259 atggcgagag gcaaccaaac catcgtctca gaattcttcc tcctggggct gtcagaagtg 60 cctgagcatc agcccctcct cttcggtctg ttcctatgca tgtacgtggt tgctgtggtg 120 gggaacctgc tcatcatcct ggccattggc tctacctcca atctccacac ccccatgtac 180 ttcttcatag ccaacctgtc ctgcgttgac atctgcttca cctctgtcac tataccaaag 240 atgctgctca atatccaaac ccagagccag tccatcccct atgttggatg cctaactcag 300 atgtattttc taatcttgtt tctagaactg gacaatgtcc tcttggcagt gatggcatat 360 gacagatttg tagccatatg tcaccctctt cattatacca taaccatgag ccctaaattc 420 tgtatcacag tggtgtctgt ggctctgatt atcacaaaca tctatccctt gatccacacc 480 ctcttgatgg atacactgtc attctgtgca agtgtcagaa ttcaccatat tttctgtgaa 540 ctctacgcat tgctaaagct ttcctgttca gatatccaca tcaatgagtt agtcgtttat 600 accctgggga gctgtctttt tgttgctcct ttcctcttta tttctgtttc ctacatgcac 660 attttctcag ccatcctaag acttcattct tcccagagca agctgaaagc cttttctact 720 tgcagttccc accttgctgt ggtgtcattg ttctatggaa ctttatttgg ggtgtatcta 780 cgaccttcgt cttcctacac aattgaagac tcagtggcca ctgtgctata tgcggtggtg 840 gctcccatgc tcaacccctt catttatagt cttaggaata aggacatgaa aggggctttg 900 aggaacctcc tcaggtggag aaagatctgg tcttggtga 939

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069269_0225_SL.TXT <210> 2260 <211> 312 <212> PRT <213> Canis familiaris

<400> 2260 Phe Phe Leu Leu 15 Gly Met 1 Ala Arg Gly Asn Gln 5 Thr Ile Val Ser 10 Glu Leu Ser Glu Val Pro Glu His Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Cys Met Tyr Val Val Ala Val Val Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Gly Ser Thr Ser Asn Leu His Thr Pro Met Tyr Phe Phe Ile Ala 50 55 60 Asn Leu Ser Cys Val Asp Ile Cys Phe Thr Ser Val Thr Ile Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Gln Ser Ile Pro Tyr Val Gly 85 90 95 Cys Leu Thr Gln Met Tyr Phe Leu Ile Leu Phe Leu Glu Leu Asp Asn 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Ile Thr Met Ser Pro Lys Phe Cys Ile Thr Val 130 135 140 Val Ser Val Ala Leu Ile Ile Thr Asn Ile Tyr Pro Leu Ile His Thr 145 150 155 160 Leu Leu Met Asp Thr Leu Ser Phe Cys Ala Ser Val Arg Ile His His 165 170 175 Ile Phe Cys Glu Leu Tyr Ala Leu Leu Lys Leu Ser Cys Ser Asp Ile

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069269_0225_SL.TXT 185 190

His Ile Asn 195 Glu Leu Val Val Tyr Thr Leu Gly Ser Cys Leu Phe Val 200 205 Ala Pro Phe Leu Phe Ile Ser Val Ser Tyr Met His Ile Phe Ser Ala 210 215 220 Ile Leu Arg Leu His Ser Ser Gln Ser Lys Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Leu Phe 245 250 255 Gly Val Tyr Leu Arg Pro Ser Ser Ser Tyr Thr Ile Glu Asp Ser Val 260 265 270 Ala Thr Val Leu Tyr Ala Val Val Ala Pro Met Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Asn Leu Leu 290 295 300 Arg Trp Arg Lys Ile Trp Ser Trp 305 310

<210> 2261 <211> 908 <212> DNA <213> Felis catus <400> 2261 tccagacttg cccttcccca tatcttcatg aatactctgg ccatttgttg tggagtctat agataagggg atttggcatg ggcataagga tggtgtagaa aacagagatc attttttctt ggatgggaga acgatctgaa gtgggcagca tgtatatgaa caatactgtt ccatagtaca ttcccaccac cctgaggtga gaggaacagg tggcaaaagc ttttcagcga ccatctccag aacccatgca aatgacagcc agcatgacac aagcatagga agcaatgatg gttgttacag ggataacaat ccttacaata cagcggtaga aaagaacttc ttcaaatgtt gagatatcat

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tgcatgagac gattagcatg gaaggaaaat cacagaagaa gttggctatt tccctgaacc 420 cacaatagga gaaagaaaac gataccatca gtagagccca ggatcaaaga agatgcggcc 480 ataagtccac aaattttagg gctcatagat tgaaatatct tagaagatgg caaatggcaa 540 cataatggtc ctaagacatg attgccaaca ggaaacattc acaacctatt agtgatgcat 600 agaagaaaat ttgtgtggca cacactgcca cagtaatgga cttgctgcca gacaagtaat 660 tgaaggccat cttgggtaca gtagtgcaga tgagtatgag atccatgagg gacagttggc 720 tgaggaggaa gtacatgggg gtgtggaact gggtgtccag gtagataagg agaaccatga 780 cagtgtttcc cgtgaaggcc accatgaaga tacagaagac caaagaaaag aggaagatgt 840 gcatagggct ttgatcaacg attcccaaaa ggatgaaatc agaggtaaat ctgattgtcc 900

catgccat 908 <210> 2262 <211> 118 <212> PRT <213> Felis catus <400> 2262

Trp His Gly Thr Ile Arg Phe Thr Ser Asp Phe Ile Leu Leu Gly Ile 1 5 10 15 Val Asp Gln Ser Pro Met His Ile Phe Leu Phe Ser Leu Val Phe Cys 20 25 30 Ile Phe Met Val Ala Phe Thr Gly Asn Thr Val Met Val Leu Leu Ile 35 40 45 Tyr Leu Asp Thr Gln Phe His Thr Pro Met Tyr Phe Leu Leu Ser Gln 50 55 60 Leu Ser Leu Met Asp Leu Ile Leu Ile Cys Thr Thr Val Pro Lys Met 65 70 75 80 Ala Phe Asn Tyr Leu Ser Gly Ser Lys Ser Ile Thr Val Ala Val Cys 85 90 95

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Ala Thr Gln Ile Phe Phe Tyr Ala Ser Leu Ile Gly Cys Glu Cys Phe 100 105 110

Leu Leu Ala Ile Met Ser 115 <210> 2263 <211> 914 <212> DNA <213> Felis catus <400> 2263

atggcaaatt ccaatgtgat gatgggattt ctcctcacag ggttttctga tgtatgggaa 60 ctgcaggttt tgcatgccat aaccttctct gtgatgttgg gaaacactgt cattgttact 120 gtcaccaccc ttgacaggag tcttcacaca cccatgtatt tcttccttag gaatctgtcc 180 atcttggttg catgctacat ttctgtaaca gttcctaact catgcatcaa ttctctactt 240 gacagcagca ccatttcaaa ggctgggtgt aaagctgagg tcttcctagt ggttttcttt 300 gtatatacgg agcttctgtt tctgactctc atggcccaag accattatgt ggctatctgc 360 caaccccttt actaccctat aatcatgaac tctcaaaatc tgcatacaaa tgactctgga 420 tttcatactc agtagtctca tctatgctgc tgtacacact ggcaatacat tcaggctgcc 480 attctgtcaa tccagtgtta tccatcagtt tttttttttt ttttttgtga tatcccttct 540 ctgctaaagc tctcctgatc tgacaccttt agcaatgaga tggtgctcat tgtctgtggt 600 ctagggattg ttggtggctg tttaattttc atcatcagct cttagagtca catgttttct 660 acagttttca agttttcgag aggagcagac agaaaaaagg ctttttctac ctgtgtctct 720 aatatatttg tggtatctgt cttcctcagc tcaggtgttt atgtatacct gaggcaatca 780 gaaaactatt ccaccatcca agacatattc cccacttttc aaccttatta tctcagtttt 840 agaaatgaac aaataaatgt gccattaata aaataaagag aatgtttact caggaaatgt 900 gcagaaaatt tctg 914

<210> 2264 <211> 144 <212> PRT <213> Felis catus

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<400> 2264 Ser Asn 5 Val Met Met Gly Phe Leu Leu Thr Gly Phe Ser Met 1 Ala Asn 10 15 Asp Val Trp Glu Leu Gln Val Leu His Ala Ile Thr Phe Ser Val Met 20 25 30 Leu Gly Asn Thr Val Ile Val Thr Val Thr Thr Leu Asp Arg Ser Leu 35 40 45 His Thr Pro Met Tyr Phe Phe Leu Arg Asn Leu Ser Ile Leu Val Ala 50 55 60 Cys Tyr Ile Ser Val Thr Val Pro Asn Ser Cys Ile Asn Ser Leu Leu 65 70 75 80 Asp Ser Ser Thr Ile Ser Lys Ala Gly Cys Lys Ala Glu Val Phe Leu 85 90 95 Val Val Phe Phe Val Tyr Thr Glu Leu Leu Phe Leu Thr Leu Met Ala 100 105 110 Gln Asp His Tyr Val Ala Ile Cys Gln Pro Leu Tyr Tyr Pro Ile Ile 115 120 125 Met Asn Ser Gln Asn Leu His Thr Asn Asp Ser Gly Phe His Thr Gln 130 135 140

<210> 2265 <211> 929 <212> DNA <213> Felis catus <400> 2265 atggcatggg agaatcagac tttcaacttt gactttatcc tcctgggaat cttcaatcac agttccaccc acatcttcct cttctctctg gtcttgggaa tcttcacatt tgccatcatg ggaaacactg tcatgattct cctcatctac ctggacaacc agctccacac ccccatgtac ttcctcctca gccaactctc cctcatggac ctcatgctca tctgcaccac tgtacccaag atggccttca actacttgtc tggcaggaag tgcatctctc tagctgggtg tggagcccag

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atatttttat atgtgtctct gcttggagca gaatgtttcc tgttggctgt aatggcctat 360 gaccgttatg ttgccatttg ccgcccatta agatactcaa ttctcatgaa ccagaaaatc 420 tgtcatctta tggtcctttc ttcctggatt gttggctctc ttgatggtat aattgttgtt 480 gcagtcgcac tatccttccc atattgtggt gcccgggaaa tacctcactt tttctgtgat 540 gtccctgccc ttctcactct ctcatgcact aatacattgc tatttgaaag gttaatgttt 600 atttgctgtg taattatgct tcttttccct gtaacagtaa ttattgcttc ctaccttcag 660 gtcattgtag ctgtcattca aatggggtct ggggaaagcc gccaaagagc ttttgctacc 720 tgttcctctc acctcatggt ggtaggaatg tattatggag cagccatgtt catatacatg 780 aggcctgttt ctgaccgttc ccccacccag gacaagatgg tgtcagcctt ttataccatc 840 cttactccta tgctgaatcc cctcatctat agcctccgca acaaggaagt ggccagagga 900 ttaatgaagg tgttagggag gggaagtct 929

<210> 2266 <211> 310 <212> PRT <213> Felis catus

<400> 2266 Asn Gln 5 Thr Phe Asn Phe Asp Phe Ile Leu Leu Gly Met Ala 1 Trp Glu 10 15 Ile Phe Asn His Ser Ser Thr His Ile Phe Leu Phe Ser Leu Val Leu 20 25 30 Gly Ile Phe Thr Phe Ala Ile Met Gly Asn Thr Val Met Ile Leu Leu 35 40 45 Ile Tyr Leu Asp Asn Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Val Pro Lys 65 70 75 80 Met Ala Phe Asn Tyr Leu Ser Gly Arg Lys Cys Ile Ser Leu Ala Gly 85 90 95

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Cys Gly Ala Gln 100 Ile Phe Leu Tyr Val Ser Leu Leu Gly Ala Glu Cys 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu Arg Tyr Ser Ile Leu Met Asn Gln Lys Ile Cys His Leu Met 130 135 140 Val Leu Ser Ser Trp Ile Val Gly Ser Leu Asp Gly Ile Ile Val Val 145 150 155 160 Ala Val Ala Leu Ser Phe Pro Tyr Cys Gly Ala Arg Glu Ile Pro His 165 170 175 Phe Phe Cys Asp Val Pro Ala Leu Leu Thr Leu Ser Cys Thr Asn Thr 180 185 190 Leu Leu Phe Glu Arg Leu Met Phe Ile Cys Cys Val Ile Met Leu Leu 195 200 205 Phe Pro Val Thr Val Ile Ile Ala Ser Tyr Leu Gln Val Ile Val Ala 210 215 220 Val Ile Gln Met Gly Ser Gly Glu Ser Arg Gln Arg Ala Phe Ala Thr 225 230 235 240 Cys Ser Ser His Leu Met Val Val Gly Met Tyr Tyr Gly Ala Ala Met 245 250 255 Phe Ile Tyr Met Arg Pro Val Ser Asp Arg Ser Pro Thr Gln Asp Lys 260 265 270 Met Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ala Arg Gly Leu Met Lys Val 290 295 300

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Leu Gly Arg Gly Ser Leu 305 310 <210> 2267 <211> 936 <212> DNA <213> Felis catus <400> 2267

atggcatggg agaatcagac cttcaactca gactttatcc tggtaggaat cttcaatgac 60 agccccactc acatcttcct tttctcactg gtcttgggca tcttcacagt ggccttcatg 120 ggaaacactg ctatggttct cctcatctgc ctggacaacc aactccacac ccccatgtac 180 ttccttctca gccaactctc cctcatggac ctcatgctca tctgcaccac tgtacccaag 240 atggccttca actacttgtc tggcaggaag tctatctctc tggctgattg tggagcccag 300 atattcttat atgtgtctct gcttggagca gaatgtttcc tgttggcttc aatggcctat 360 gaccgttatg ttgccatttg ccacccatta agatactcaa ttctcatgaa ccagaaaata 420 tgtggtctca tggcagcttt ttcatggatt cttggctcac ttgatggtat aattgaagct 480 gcagttgcat tgtctttctc atattgtggt gcccgagaaa taccccactt tttctgtgat 540 gtccctgccc ttctcactct ctcatgcact aacacattgt tatttgaaag gatgatattt 600 atatgctgta ttattatgct tcttttccct gtagcagtaa tcattgcttc ttatgttcat 660 gttattgtgg ctgtcattca catgggatct ggagagggcc cacgtaaagc ttttggcacc 720 tgttcttctc acctcatggt agtaggaatg tattacggag cagccatgtt catatacatg 780 aggcccagtt cagatcgtac ccccacccag gacaaattcg tgtctgtctt ctacactatc 840 cttactccca tgctgaatcc tctcatctat agcctccgca acaaggatgt ggccagagca 900 ttcatgaaag tgttaggaag gggtaagtct ggagag 936

<210> 2268 <211> 312 <212> PRT <213> Felis catus <400> 2268

Met Ala Trp Glu Asn Gln Thr Phe Asn Ser Asp Phe Ile Leu Val Gly Page 2508

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1 5 10 15 Ile Phe Asn Asp Ser Pro Thr His Ile Phe Leu Phe Ser Leu Val Leu 20 25 30 Gly Ile Phe Thr Val Ala Phe Met Gly Asn Thr Ala Met Val Leu Leu 35 40 45 Ile Cys Leu Asp Asn Gln Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Met Asp Leu Met Leu Ile Cys Thr Thr Val Pro Lys 65 70 75 80 Met Ala Phe Asn Tyr Leu Ser Gly Arg Lys Ser Ile Ser Leu Ala Asp 85 90 95 Cys Gly Ala Gln Ile Phe Leu Tyr Val Ser Leu Leu Gly Ala Glu Cys 100 105 110 Phe Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Ser Ile Leu Met Asn Gln Lys Ile Cys Gly Leu Met 130 135 140 Ala Ala Phe Ser Trp Ile Leu Gly Ser Leu Asp Gly Ile Ile Glu Ala 145 150 155 160 Ala Val Ala Leu Ser Phe Ser Tyr Cys Gly Ala Arg Glu Ile Pro His 165 170 175 Phe Phe Cys Asp Val Pro Ala Leu Leu Thr Leu Ser Cys Thr Asn Thr 180 185 190 Leu Leu Phe Glu Arg Met Ile Phe Ile Cys Cys Ile Ile Met Leu Leu 195 200 205 Phe Pro Val Ala Val Ile Ile Ala Ser Tyr Val His Val Ile Val Ala

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215

069269_0225_SL.TXT

220

Val Ile 225 His Met Gly Ser Gly Glu Gly Pro Arg Lys Ala Phe Gly Thr 230 235 240 Cys Ser Ser His Leu Met Val Val Gly Met Tyr Tyr Gly Ala Ala Met 245 250 255 Phe Ile Tyr Met Arg Pro Ser Ser Asp Arg Thr Pro Thr Gln Asp Lys 260 265 270 Phe Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Ala Arg Ala Phe Met Lys Val 290 295 300 Leu Gly Arg Gly Lys Ser Gly Glu

305 310 <210> 2269 <211> 932 <212> DNA <213> Felis catus <400> 2269

atggaaaaca ccacttgggt agtcaaccat actggactag attttgacct agtaggactc 60 ttcagtcaat ataagtaccc agctctcctt tgtgtgatcg tctttgtggt tttcctgatg 120 gccctgtctg gaaatatcat cctgatcctt gtgatatact gtgatgccca ccttcataac 180 cctatgtact tttttatcac ccagttgtct ttcatggatg tgatgtacat ttctgtcact 240 gtgcccaaga tgctcatgga ccaggtcttg ggtgtaaata agatctcagc ccctgaatgc 300 gggatgcaga tgtttctcta tttgacatta ggaggttcag aagttttcct tctagctgcc 360 atggcctatg accgctatgt ggccatctgt catccactcc tttatcctat cctaatgaac 420 catagggtgt gtctcctctt ggtctcttct tcatggtttc tgggatcttt ggatggattt 480 actctcacac ctgtcaccat gacattcccc ttctgtagat cccgggagat ccaccatttc 540 ttctgtgagg ttcctgctgt aatgaagctt tcctgctcag acacttccct ctatgagaca 600

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ctcatgtact tatgttgtgt tctcatgctc ctcattcctg tgacagtcat ttcaagttcc 660 tattctttta tcctctttac catccacagg atgaactcag cagtgggaca gaagaaggcc 720 tttgccactt gttcttccca catgactgtg gtcatcctct tctatggggc ttctgtctat 780 acctacatgc tccccacctc ctaccacacc cctgagaagg acatgattgt atcttttctt 840 tataccatac tcactcctgt tctaaaccct ttaatttata gtcttaggaa taaggatgtc 900 acaagggctc taaaaagaat gttaaatgtg gg 932

<210> 2270 <211> 311 <212> PRT <213> Felis catus <400> 2270

Met Glu Asn Thr Thr Trp Val Val Asn His Thr Gly Leu Asp Phe Asp 1 5 10 15 Leu Val Gly Leu Phe Ser Gln Tyr Lys Tyr Pro Ala Leu Leu Cys Val 20 25 30 Ile Val Phe Val Val Phe Leu Met Ala Leu Ser Gly Asn Ile Ile Leu 35 40 45 Ile Leu Val Ile Tyr Cys Asp Ala His Leu His Asn Pro Met Tyr Phe 50 55 60 Phe Ile Thr Gln Leu Ser Phe Met Asp Val Met Tyr Ile Ser Val Thr 65 70 75 80 Val Pro Lys Met Leu Met Asp Gln Val Leu Gly Val Asn Lys Ile Ser 85 90 95 Ala Pro Glu Cys Gly Met Gln Met Phe Leu Tyr Leu Thr Leu Gly Gly 100 105 110 Ser Glu Val Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125

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Ile Cys 130 His Pro Leu Leu Tyr 135 069269_0225_SL.TXT Pro Ile Leu Met Asn His 140 Arg Val Cys Leu Leu Leu Val Ser Ser Ser Trp Phe Leu Gly Ser Leu Asp Gly Phe 145 150 155 160 Thr Leu Thr Pro Val Thr Met Thr Phe Pro Phe Cys Arg Ser Arg Glu 165 170 175 Ile His His Phe Phe Cys Glu Val Pro Ala Val Met Lys Leu Ser Cys 180 185 190 Ser Asp Thr Ser Leu Tyr Glu Thr Leu Met Tyr Leu Cys Cys Val Leu 195 200 205 Met Leu Leu Ile Pro Val Thr Val Ile Ser Ser Ser Tyr Ser Phe Ile 210 215 220 Leu Phe Thr Ile His Arg Met Asn Ser Ala Val Gly Gln Lys Lys Ala 225 230 235 240 Phe Ala Thr Cys Ser Ser His Met Thr Val Val Ile Leu Phe Tyr Gly 245 250 255 Ala Ser Val Tyr Thr Tyr Met Leu Pro Thr Ser Tyr His Thr Pro Glu 260 265 270 Lys Asp Met Ile Val Ser Phe Leu Tyr Thr Ile Leu Thr Pro Val Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Arg Ala Leu 290 295 300 Lys Arg Met Leu Asn Val Gly 305 310

<210> 2271 <211> 959 <212> DNA <213> Felis catus

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069269_0225_SL.TXT <400> 2271 taagcatcac ttgtggatac tttctgagca gataaacatc ttgacagtat cttttgaaat 60 gcccccatga catccttgtt tctgaggctg tagataagag gattgagcat gggtgtgaca 120 atggtataga aggctgaaac tactttgtcc tgctcaggag tgtgaaaaga ctggggcaga 180 acataagtgt agaaggcagc cccatagaaa atgctgacca cagtcaagtg ggaagagcaa 240 gtagtaaagg cctttttccg gccttcagca gagcgcattc tgtggacagt taacaaaata 300 agagagtagg agattgagat gatagagata gggatgagca acatgagtac acagcagatg 360 tacatcaagg tttcatacaa ggatgtgtca gcacaggcta gtctgagaac tgcagggatc 420 tcacagaaaa aatggttgat atttcgggag tgacaatagg gaacattcat ggtgatgggg 480 gtgagcagaa agccatccag ggacccccca aaccaggcac cagcagccag caggagacac 540 accctgcggt tcatcaggac tggataccta agagggttac agacagccac atagcggtca 600 taggccatga ggcccaagag gaagaactcc gagccaatca tgctcaagta gaggaagatc 660 tggatgccgc aacccacaaa ggaaatggtc ttctctttag aaaccatgtc gaccagaagt 720 tttgggacag tggtacaaat gaaaagagta tccatgatgg acagctggct gagcagaaag 780 tacataggag tatggagacg ggagtccacc tgaatcaaga atatcatgac caaatttgca 840 gttacagcta ccacaaaaat agcaaaaata acagcaaaga caatcccagt agttttattg 900 ttcaccagaa gccccaggag gataaaatca gaagataaag ttatattctt catttacat 959 <210> 2272 <211> 318 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (318)..(318) <223> Any amino acid <400> 2272

Met Lys Asn Ile Thr Leu Ser Ser Asp Phe Ile Leu Leu Gly Leu Leu

1 5 10 15

Val Asn Asn Lys Thr Thr Gly Ile Val Phe Ala Val Ile Phe Ala Ile

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Phe Val Val 35 Ala Val Thr Ala Asn Leu Val Met Ile Phe Leu Ile Gln 40 45 Val Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu 50 55 60 Ser Ile Met Asp Thr Leu Phe Ile Cys Thr Thr Val Pro Lys Leu Leu 65 70 75 80 Val Asp Met Val Ser Lys Glu Lys Thr Ile Ser Phe Val Gly Cys Gly 85 90 95 Ile Gln Ile Phe Leu Tyr Leu Ser Met Ile Gly Ser Glu Phe Phe Leu 100 105 110 Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asn Pro Leu 115 120 125 Arg Tyr Pro Val Leu Met Asn Arg Arg Val Cys Leu Leu Leu Ala Ala 130 135 140 Gly Ala Trp Phe Gly Gly Ser Leu Asp Gly Phe Leu Leu Thr Pro Ile 145 150 155 160 Thr Met Asn Val Pro Tyr Cys His Ser Arg Asn Ile Asn His Phe Phe 165 170 175 Cys Glu Ile Pro Ala Val Leu Arg Leu Ala Cys Ala Asp Thr Ser Leu 180 185 190 Tyr Glu Thr Leu Met Tyr Ile Cys Cys Val Leu Met Leu Leu Ile Pro 195 200 205 Ile Ser Ile Ile Ser Ile Ser Tyr Ser Leu Ile Leu Leu Thr Val His 210 215 220 Arg Met Arg Ser Ala Glu Gly Arg Lys Lys Ala Phe Thr Thr Cys Ser

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0 6926 >9_02 25_S iL.TX T 225 230 235 240 Ser His Leu Thr Val Val Ser Ile Phe Tyr Gly Ala Ala Phe Tyr Thr 245 250 255 Tyr Val Leu Pro Gln Ser Phe His Thr Pro Glu Gln Asp Lys Val Val 260 265 270 Ser Ala Phe Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Met Gly Ala Phe Gln Lys Ile Leu Ser 290 295 300 Arg Cys Leu Ser Ala Gln Lys Val Ser Thr Ser Asp Ala Xaa 305 310 315

<210> 2273 <211> 975 <212> DNA <213> Felis catus <400> 2273 ctagtgtttc ctggacaaat ccaccactct ggttttctgg gaggaggggc atctactcag cacttttctt agagctgtag ccacatcttt attcctcaag ctgtagatga gtggattgag cattggggtg aggatggtgt agaaagcgga tacaatcttg tctttctctg gtgtgtggta ggaatgtggc aacacattgg tgtagaaggc tgccccatag aaaatgctta ctaccattat atgggaagaa caggtagcta aggctttgca ccggccctca gcagaattaa tgtgatggac agtgagcagg atgcgtgtgt aggaaacaga gattacggat ataggaatga gcagcattag cacgcagcag gcgtacatca gagtctcata gagagacgtg tcaacacatg acagtttcag tacagctggg atctcacaga aaaaatgatt gatttctcgg gagccacagt aggggaaact catagtgaag ggggtcagca tgaacccatc taaggagcca ccaacccagg aacccaccac catgaacaag caaatcctgc gattcatgag gagagggtac cgaaggggtt tgcatacagc cacgtatcgg tcataagcca tgagacctag caggaaaaat tcacctccaa ctagtgtcag gtagaggaag atctgaagtg tgcatccaaa gaaagagatg atcttttcct tggacagaag Page 2515

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069269_0225_SL.TXT gtcttgcagc atcttgggaa cggtgataca gatgtaaact gtgtccataa tggagagctg gctgagtaaa aagtacatgg gtgtattcag gcgagagtcc acatggatga gcagaatcat gaccacattg gctgttacag acaccagaaa aatggagaag actactgcaa aaataagccc agggaattca gggtgggtga tgaggcccaa gaggatgaaa tcagtggagt tctggagaat ggcttccatg atcat

780

840

900

960

975 <210> 2274 <211> 324 <212> PRT <213> Felis catus <400> 2274

Met 1 Ile Met Glu Ala Ile Leu Gln Asn Ser Thr Asp Phe Ile Leu Leu 5 10 15 Gly Leu Ile Thr His Pro Glu Phe Pro Gly Leu Ile Phe Ala Val Val 20 25 30 Phe Ser Ile Phe Leu Val Ser Val Thr Ala Asn Val Val Met Ile Leu 35 40 45 Leu Ile His Val Asp Ser Arg Leu Asn Thr Pro Met Tyr Phe Leu Leu 50 55 60 Ser Gln Leu Ser Ile Met Asp Thr Val Tyr Ile Cys Ile Thr Val Pro 65 70 75 80 Lys Met Leu Gln Asp Leu Leu Ser Lys Glu Lys Ile Ile Ser Phe Phe 85 90 95 Gly Cys Thr Leu Gln Ile Phe Leu Tyr Leu Thr Leu Val Gly Gly Glu 100 105 110 Phe Phe Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys 115 120 125 Lys Pro Leu Arg Tyr Pro Leu Leu Met Asn Arg Arg Ile Cys Leu Phe

130 135 140

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Met Val Val Gly Ser Trp Val Gly Gly Ser Leu Asp Gly Phe Met 155 Leu 160 145 150 Thr Pro Phe Thr Met Ser Phe Pro Tyr Cys Gly Ser Arg Glu Ile Asn 165 170 175 His Phe Phe Cys Glu Ile Pro Ala Val Leu Lys Leu Ser Cys Val Asp 180 185 190 Thr Ser Leu Tyr Glu Thr Leu Met Tyr Ala Cys Cys Val Leu Met Leu 195 200 205 Leu Ile Pro Ile Ser Val Ile Ser Val Ser Tyr Thr Arg Ile Leu Leu 210 215 220 Thr Val His His Ile Asn Ser Ala Glu Gly Arg Cys Lys Ala Leu Ala 225 230 235 240 Thr Cys Ser Ser His Ile Met Val Val Ser Ile Phe Tyr Gly Ala Ala 245 250 255 Phe Tyr Thr Asn Val Leu Pro His Ser Tyr His Thr Pro Glu Lys Asp 260 265 270 Lys Ile Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Ala Thr Ala Leu Arg Lys 290 295 300 Val Leu Ser Arg Cys Pro Ser Ser Gln Lys Thr Arg Val Val Asp Leu 305 310 315 320

Ser Arg Lys His <210> 2275 <211> 954

Page 2517

<212> DNA <213> Felis catus 069269_0225_SL.TXT <400> 2275 ttagaacgtg gatacacttc ctgatgacaa acacttgccc agagctttct gtagagcccc 60 tgtaacatcc ttgttcctga ggctatagat gagtgggttg agcaagggag tgaggatagt 120 gtagaaggca gacacagcct tgtccttgtc aggggtatgg taagagtgag gcagcacata 180 ggtgtacatg gcagccccat agaaaaggct gacaaccacc atgtgtgagg agcaagtggc 240 cactgccttt cgtctcccct ctgcttcact cattctataa acagtgatga gaatccttgt 300 ataagaggct gagatgacag agaaagggat gaggagcatc atgatgcagc agacatacat 360 ggctgtctcg taagttgatg tgtcagtaca ggagagcttc agaagggcag gaacctcaca 420 gaagaagtgg ttgatttctc gagaggcaca gaacgggaac tgcatggtga ctggggtaag 480 caggaagcca tctatggacc ctcccagcca ggctgccagt acaatcaaca tgcagacctt 540 tcggctcatg aggacaggat agcgcaaagg gttacagatg gctacatagc ggtcataaga 600 catgagtcct aggagaaaaa actcagcccc tgccaatgtc aggtaaagga agtgctgggc 660 agtgcatcct gcaaaggata tggccctctg gcccaagatc tggtcaacca gcatttttgg 720 cacaatggtg gaaatgtaca agatgtccat gagggagagt tgactgagca agtagtacat 780 gggggtgtgg aggcgggagt ctatgtggat cagaatgatc atgatggtgt tgctggctat 840 ggagatgaca aaaataaaga ggatgagggc aaagagaagc cagggaaaat cattgtcact 900 gaacaagccc aggagaagaa agtcggcata catggaataa ttgccccact ccat 954

<210> 2276 <211> 317 <212> PRT <213> Felis catus

<400> 2276 Met Glu Trp Gly Asn Tyr Ser Met Tyr Ala Asp Phe Leu Leu Leu Gly 1 5 10 15 Leu Phe Ser Asp Asn Asp Phe Pro Trp Leu Leu Phe Ala Leu Ile Leu 20 25 30 Phe Ile Phe Val Ile Ser Ile Ala Ser Asn Thr Ile Met Ile Ile Leu Page 251! 8

069269_0225_SL.TXT 40 45

Ile His Ile Asp Ser Arg Leu His Thr Pro Met Tyr Tyr Leu Leu Ser 50 55 60 Gln Leu Ser Leu Met Asp Ile Leu Tyr Ile Ser Thr Ile Val Pro Lys 65 70 75 80 Met Leu Val Asp Gln Ile Leu Gly Gln Arg Ala Ile Ser Phe Ala Gly 85 90 95 Cys Thr Ala Gln His Phe Leu Tyr Leu Thr Leu Ala Gly Ala Glu Phe 100 105 110 Phe Leu Leu Gly Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Leu Met Ser Arg Lys Val Cys Met Leu Ile 130 135 140 Val Leu Ala Ala Trp Leu Gly Gly Ser Ile Asp Gly Phe Leu Leu Thr 145 150 155 160 Pro Val Thr Met Gln Phe Pro Phe Cys Ala Ser Arg Glu Ile Asn His 165 170 175 Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Thr Asp Thr 180 185 190 Ser Thr Tyr Glu Thr Ala Met Tyr Val Cys Cys Ile Met Met Leu Leu 195 200 205 Ile Pro Phe Ser Val Ile Ser Ala Ser Tyr Thr Arg Ile Leu Ile Thr 210 215 220 Val Tyr Arg Met Ser Glu Ala Glu Gly Arg Arg Lys Ala Val Ala Thr 225 230 235 240 Cys Ser Ser His Met Val Val Val Ser Leu Phe Tyr Gly Ala Ala Met

Page 2519

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245 250 255

Tyr Thr Tyr Val Leu Pro His Ser Tyr 265 His Thr Pro Asp Lys 270 Asp Lys 260 Ala Val Ser Ala Phe Tyr Thr Ile Leu Thr Pro Leu Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Gly Ala Leu Gln Lys Ala 290 295 300 Leu Gly Lys Cys Leu Ser Ser Gly Ser Val Ser Thr Phe 305 310 315

<210> 2277 <211> 957 <212> DNA <213> Felis catus <400> 2277 tcaaaacaca tctcctgaca ctttttgtgt acatttgaac ctgcccattg ccctcttcag agctccagtc acatccttgt tcctcagact gtagatgagt ggattcagca ttggtgtaag gattgtgtag aacacagaga agactgtatc ctgcgctggg ttatggtaag agtgtggcag catgtaggtg tacatggcag ccccatagaa caaggtcact actgtcatgt gagatgaaca ggtggcaaat gccttctttc ttccctcaac tgaactcatg tggtggactg tggtcaggat ttgggcataa gaagccagca ctacagagaa aggaatcagc aacatcagga cacagcacac atacattact gtttcataga gggctgtgtc tgcacatgcc aaactcaaga ctgcaggtgc ctcacaaaag aaatggttaa tttcccggga gttgcagaaa ggaaaggtca tggttatggg agttagaagg aagccatcca aaaagcctcc aaaccaggaa cctgctatga tcatccaaca gacctggcga ctcataagga cagggtagcg aagggggtta cagatggcca catagcagtc ataggccatg aggcccagta ggaagaactc agctcccaca agggtgaggt agaggaagtg ctgagctgtg caccccataa aggatatggt tctttgaccc agcagataat caaccagcat cttgggcaca atggtggaga tatacatcat gtcaatgaag gagagatggc tgagaaggaa gtacatagga gtgtgcagtc gtgaatcagt gtggatcagg aagatcataa tcccattggc

120

180

240

300

360

420

480

540

600

660

720

780

840

Page 2520

069269_0225_SL.TXT catcaatgca gtgaaaaaga tgatagagac aatggcaaag agaaggcctg agatgtcctt cttgttgaac agtcccatca aggtgaagtc tgtagaggat gtgttgtaca cttccat

900

957 <210> 2278 <211> 318 <212> PRT <213> Felis catus

<400> 2278 Thr Ser Ser Thr Asp Phe Thr Leu Met Gly Leu Met Glu 1 Val Tyr Asn 5 10 15 Phe Asn Lys Lys Asp Ile Ser Gly Leu Leu Phe Ala Ile Val Ser Ile 20 25 30 Ile Phe Phe Thr Ala Leu Met Ala Asn Gly Ile Met Ile Phe Leu Ile 35 40 45 His Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser His 50 55 60 Leu Ser Phe Ile Asp Met Met Tyr Ile Ser Thr Ile Val Pro Lys Met 65 70 75 80 Leu Val Asp Tyr Leu Leu Gly Gln Arg Thr Ile Ser Phe Met Gly Cys 85 90 95 Thr Ala Gln His Phe Leu Tyr Leu Thr Leu Val Gly Ala Glu Phe Phe 100 105 110 Leu Leu Gly Leu Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Asn Pro 115 120 125 Leu Arg Tyr Pro Val Leu Met Ser Arg Gln Val Cys Trp Met Ile Ile 130 135 140 Ala Gly Ser Trp Phe Gly Gly Phe Leu Asp Gly Phe Leu Leu Thr Pro 145 150 155 160

Page 2521

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Ile Thr Met Thr Phe Pro Phe Cys Asn Ser 170 Arg Glu Ile Asn His 175 Phe 165 Phe Cys Glu Ala Pro Ala Val Leu Ser Leu Ala Cys Ala Asp Thr Ala 180 185 190 Leu Tyr Glu Thr Val Met Tyr Val Cys Cys Val Leu Met Leu Leu Ile 195 200 205 Pro Phe Ser Val Val Leu Ala Ser Tyr Ala Gln Ile Leu Thr Thr Val 210 215 220 His His Met Ser Ser Val Glu Gly Arg Lys Lys Ala Phe Ala Thr Cys 225 230 235 240 Ser Ser His Met Thr Val Val Thr Leu Phe Tyr Gly Ala Ala Met Tyr 245 250 255 Thr Tyr Met Leu Pro His Ser Tyr His Asn Pro Ala Gln Asp Thr Val 260 265 270 Phe Ser Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Thr Gly Ala Leu Lys Arg Ala Met 290 295 300 Gly Arg Phe Lys Cys Thr Gln Lys Val Ser Gly Asp Val Phe 305 310 315 <210> 2279 <211> 960 <212> DNA <213> Felis catus <400> 2279 tcagaatcct tcccgtgtca caccacgaat cccttgacat cttgccaaga cccttttaaa ggccccggtt , acatctgtgt ttctcaagct gtaaatgaga ggatttaaca aaggagtgag aatggtgtaa aaggcggaga agaccttgtc tttgatcggt gtgtggtagg attggggaac

120

180

Page 2522

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catatatgta tacagggcag ccccataaaa caaggtcacc accattatgt gtgatgagca 240 ggtggcaaaa gccttcttct tcccttctgc tgacttcatc tggtgcactg tgatgagaat 300 tcgggcatag gaagcaatta tcacagagaa ggggatcagc agcatcatga cacagcaaac 360 atacattacc atttcatagg cagctttgtc accacaggcc agcctcagca tggtaggtgc 420 ttcacagaag aagtgattga tcttgcggga actgcagaat gggagactca tggtgatcgg 480 agtgaggagg aagctgtcca aagcaccacc aaaccaagag ctggccaaga tcatccaaca 540 gacccggtgg ctcataagaa caggatagcg aagcgggttg cagatggcca catagcggtc 600 ataagccatg agtcctagca ggaaaaattc agcccccaca aagcccatgt agagaaagtg 660 ctgggctgta caggcaacga aggagatagt ccccttgccc acaagataat tgaccagcat 720 cttgggcaca atggtagaga tgtacatcat gtcaatgaag gagaggtggc tgagcaggaa 780 gtacatgggg gtatggaggt aagggtctat atggatcagg aagatcatga ccccattaac 840 tatcatggcc atgaagaata cagcacaaat tatgctgaaa aggaagcctg aggttgcacc 900 atgagtgaag agccctatga gggtgaagtc actggaacaa gttttattgt ctccaaccat 960

<210> 2280 <211> 319 <212> PRT <213> Felis catus <400> 2280

Met Val Gly Asp Asn Lys Thr Cys Ser Ser Asp Phe Thr Leu Ile Gly 1 5 10 15 Leu Phe Thr His Gly Ala Thr Ser Gly Phe Leu Phe Ser Ile Ile Cys 20 25 30 Ala Val Phe Phe Met Ala Met Ile Val Asn Gly Val Met Ile Phe Leu 35 40 45 Ile His Ile Asp Pro Tyr Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 His Leu Ser Phe Ile Asp Met Met Tyr Ile Ser Thr Ile Val Pro Lys 65 70 75 80

Page 2523

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Met Leu Val Asn Tyr Leu Val Gly Lys Gly Thr Ile Ser Phe Val Ala 85 90 95 Cys Thr Ala Gln His Phe Leu Tyr Met Gly Phe Val Gly Ala Glu Phe 100 105 110 Phe Leu Leu Gly Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Leu Met Ser His Arg Val Cys Trp Met Ile 130 135 140 Leu Ala Ser Ser Trp Phe Gly Gly Ala Leu Asp Ser Phe Leu Leu Thr 145 150 155 160 Pro Ile Thr Met Ser Leu Pro Phe Cys Ser Ser Arg Lys Ile Asn His 165 170 175 Phe Phe Cys Glu Ala Pro Thr Met Leu Arg Leu Ala Cys Gly Asp Lys 180 185 190 Ala Ala Tyr Glu Met Val Met Tyr Val Cys Cys Val Met Met Leu Leu 195 200 205 Ile Pro Phe Ser Val Ile Ile Ala Ser Tyr Ala Arg Ile Leu Ile Thr 210 215 220 Val His Gln Met Lys Ser Ala Glu Gly Lys Lys Lys Ala Phe Ala Thr 225 230 235 240 Cys Ser Ser His Ile Met Val Val Thr Leu Phe Tyr Gly Ala Ala Leu 245 250 255 Tyr Thr Tyr Met Val Pro Gln Ser Tyr His Thr Pro Ile Lys Asp Lys 260 265 270 Val Phe Ser Ala Phe Tyr Thr Ile Leu Thr Pro Leu Leu Asn Pro Leu 275 280 285

Page 2524

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Ile Tyr Ser Leu Arg Asn Thr Asp Val Thr Gly Ala Phe Lys Arg Val 290 295 300

Leu Ala Arg Cys Gln Gly Ile Arg Gly Val Thr Arg Glu Gly Phe 305 310 315 <210> 2281 <211> 963 <212> DNA <213> Felis catus <400> 2281

ctacttttaa gtttcgtgaa agacacgttc cacattccac attttcttca gagccccaat 60 aacatcctta tttcttagac tatagatcaa agggttgagc acaggagtga gtattgtgta 120 aaagacagat accatcatgt ccttctcagg tgtatggtag gacttgggga gcatgtaagt 180 ataaatggca gccccataga agaggatgac cacagtcatg tgggaagaac aagtggcaaa 240 ggccttcttt tggccttctg ctgagttcat cctatggatg gtgatgagga taaagtagta 300 ggatcctgaa atgactgtca caggaatgag aagcatgagg acacagcaca agtacatgaa 360 aatctcatag atggaggtgt ctgaacaaga gagtttcaac accgctggga cttcacagaa 420 gaaatgatgg atctcccgag atctgcagaa ggggaaggtc atggtgatgg gagtgaacaa 480 gaagccatcc actgaaccca ggaaccagca gccagatgct agaaggagaa acaccctagg 540 gttcatgagg actgggtaac ggaggggatg gcagatggct acatagcggt cataggccat 600 agaggctaga agaaaaaatt ctgaacctgc tagtgtcaca tagagaaaca tctgtatccc 660 acattctgtg gttgagatct tgttcatacc catgacttgg tccatgagca tcttcggcac 720 agtaacagaa atgtacatta tgtccatgag agacagctgg ctgatgaaaa agtacatggg 780 ggtgtggagg taggcatcag aatgtatcag taggatcaga atggtgtttc cagtcaaggc 840 catcaggaaa gccacaaaaa tcaccaaaca aaggagagct gggtgtttgg attcactgaa 900 gattcccacc aggatgaaat ctgacctcgc agtgtagtta gccacccagt tggttttctc 960

cat 963 <210> 2282 <211> 318

Page 2525

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 2282 Phe Met 1 Glu Lys Thr Asn Trp Val Ala 5 Asn Tyr 10 Thr Ala Arg Ser Asp 15 Ile Leu Val Gly Ile Phe Ser Glu Ser Lys His Pro Ala Leu Leu Cys 20 25 30 Leu Val Ile Phe Val Ala Phe Leu Met Ala Leu Thr Gly Asn Thr Ile 35 40 45 Leu Ile Leu Leu Ile His Ser Asp Ala Tyr Leu His Thr Pro Met Tyr 50 55 60 Phe Phe Ile Ser Gln Leu Ser Leu Met Asp Ile Met Tyr Ile Ser Val 65 70 75 80 Thr Val Pro Lys Met Leu Met Asp Gln Val Met Gly Met Asn Lys Ile 85 90 95 Ser Thr Thr Glu Cys Gly Ile Gln Met Phe Leu Tyr Val Thr Leu Ala 100 105 110 Gly Ser Glu Phe Phe Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Val Leu Met Asn Pro Arg Val 130 135 140 Phe Leu Leu Leu Ala Ser Gly Cys Trp Phe Leu Gly Ser Val Asp Gly 145 150 155 160 Phe Leu Phe Thr Pro Ile Thr Met Thr Phe Pro Phe Cys Arg Ser Arg 165 170 175 Glu Ile His His Phe Phe Cys Glu Val Pro Ala Val Leu Lys Leu Ser 180 185 190

Page 2526

Cys Ser Asp 195 Thr Ser Ile Tyr 069269_0225_SL.TXT Glu Ile Phe Met Tyr Leu 200 205 Cys Cys Val Leu Met Leu Leu Ile Pro Val Thr Val Ile Ser Gly Ser Tyr Tyr Phe 210 215 220 Ile Leu Ile Thr Ile His Arg Met Asn Ser Ala Glu Gly Gln Lys Lys 225 230 235 240 Ala Phe Ala Thr Cys Ser Ser His Met Thr Val Val Ile Leu Phe Tyr 245 250 255 Gly Ala Ala Ile Tyr Thr Tyr Met Leu Pro Lys Ser Tyr His Thr Pro 260 265 270 Glu Lys Asp Met Met Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Val 275 280 285 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Ile Gly Ala 290 295 300 Leu Lys Lys Met Trp Asn Val Glu Arg Val Phe His Glu Thr 305 310 315

<210> 2283 <211> 957 <212> DNA <213> Felis catus <400> 2283

tattttctaa tttattgaaa gacagttccc acattcaaca ttttctttaa agtccttgtg 60 acatctttat tcctcagact atagattaaa ggatttagca gtggaaggag gatggtataa 120 aaaacagata ccattatgtc cttttcaggg atgtagtgaa agctgggaag catggagttg 180 tagactccag ccccaaaaaa gaggataaca acagtcatat gggaggaaaa agttgcaaag 240 gacttcttct ggctctttgc tgagttcatc ctgtagatgg tgaggaggat gaaaaaatag 300 gagtttgaaa tgactctcac tgggaaaagg agcgtgagga cacaacacag gtacatgagt 360 gtctcatgga gggaagtgag caggaaagct ttactatgtc aggaacttca cagaagaaat 420

Page 2527

069269_0225_SL.TXT

gatggatctc cagagatctg cagaaaggga atgccatggt gacagatgtg agcatgaatc 480 catccacaga tgccagaaac cagcagccaa ataccagtag gagacaaacc ctatggttca 540 tgatgacagg ataataaaga gactggcaga ggcaacatag tagtcatagg ctatggtggc 600 tagaaggaaa cattctgaac ctcctagtat cacatagaga aacatttgta tcccacagtc 660 gagggttgag atcttattca cacccataac ctggtccata agcatctcgg gcacagtgat 720 ataaatgtac attacatcca tgggagacaa ctggctgatg aaaaagtaca taggggtgtg 780 cagataagca tcacagtata tcagaaatat caggatagag tttccagaca ataccaacaa 840 gaaaaacaca aaaatgacca cacagaggag agttgggtgt tttgactgac tgaaaattcc 900 caccaggatg aaatcagact gtgccgtttc attgaccacc cgagttttgt tgtccat 957

<210> 2284 <211> 139 <212> PRT <213> Felis catus

<400> 2284 Arg Val Val Asn Glu Thr Ala Gln Ser Asp Phe Met Asp 1 Asn Lys Thr 5 10 15 Ile Leu Val Gly Ile Phe Ser Gln Ser Lys His Pro Thr Leu Leu Cys 20 25 30 Val Val Ile Phe Val Phe Phe Leu Leu Val Leu Ser Gly Asn Ser Ile 35 40 45 Leu Ile Phe Leu Ile Tyr Cys Asp Ala Tyr Leu His Thr Pro Met Tyr 50 55 60 Phe Phe Ile Ser Gln Leu Ser Pro Met Asp Val Met Tyr Ile Tyr Ile 65 70 75 80 Thr Val Pro Glu Met Leu Met Asp Gln Val Met Gly Val Asn Lys Ile 85 90 95 Ser Thr Leu Asp Cys Gly Ile Gln Met Phe Leu Tyr Val Ile Leu Gly 100 105 110

Page 2528

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Gly Ser Glu Cys Phe Leu Leu Ala Thr Ile Ala Tyr Asp Tyr Tyr Val 115 120 125 Ala Ser Ala Ser Leu Phe Ile Ile Leu Ser Ser

130 135 <210> 2285 <211> 963 <212> DNA <213> Felis catus <400> 2285

atggagaaca acacttgggt gaacaaccat actggacgat cagattttga cctagtggga 60 ctcttcagtc aatccaagca cccagctctc ctttgtgtgg taattttagt ggatttcctg 120 atggctttgt ctggaaacat catcctgatc cttctgatat actttgatgc tcaccttcat 180 aatcccatgt acttttttat cacccagttg tctctcatgg atgtgatgta catttctgtc 240 actgtgccca agatgctcat ggaccaggtc atgggtgtga ataagatctc agcccccgaa 300 tgtgggatgc agatgtttct ctatttgaca ctaggaggtt cagaattttt ccttctagca 360 gctatggcct atgaccgcta tgtggctatc tgccatccac tccgttatcc tatcctcatg 420 aacaataggg tgtgtctcct cctggtgtct tcttcctggt ttctgggatc tgtggatgga 480 tttatgataa cccccatcac catgacctta cccgtctgca gatctcggga gatctatcat 540 ttcttctgtg aagttcctgc tgtaatgaaa ctttcctgct cagacacttc cctctatgag 600 acattcatgt acctctgttg tgtcatctca ctcctcttcc ctgtgacagt catttcaagc 660 tcctattctt tcatcctctt caccatccac aggatgaagt cagcagaggg gcggaagaag 720 gcctttgcca cttgttcttc ccacatgacc gtggtcgtcc tcttctatgg ggctgctgtc 780 tatacctaca tgctccccaa cacctaccac acccctgaga aggacctgat tgtatctgtc 840 ttttacacca tactcactcc tgttctacac cctttaattt atagtcttag gaataaggat 900 gttacaaggg ctctaaaaaa aatgttgaat gttaagtctg tctctcagga aagtataaaa 960

taa 963 <210> 2286 <211> 320

Page 2529

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 2286 Asp Phe 15 Met 1 Glu Asn Asn Thr Trp Val Asn 5 Asn His 10 Thr Gly Arg Ser Asp Leu Val Gly Leu Phe Ser Gln Ser Lys His Pro Ala Leu Leu Cys 20 25 30 Val Val Ile Leu Val Asp Phe Leu Met Ala Leu Ser Gly Asn Ile Ile 35 40 45 Leu Ile Leu Leu Ile Tyr Phe Asp Ala His Leu His Asn Pro Met Tyr 50 55 60 Phe Phe Ile Thr Gln Leu Ser Leu Met Asp Val Met Tyr Ile Ser Val 65 70 75 80 Thr Val Pro Lys Met Leu Met Asp Gln Val Met Gly Val Asn Lys Ile 85 90 95 Ser Ala Pro Glu Cys Gly Met Gln Met Phe Leu Tyr Leu Thr Leu Gly 100 105 110 Gly Ser Glu Phe Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Ile Leu Met Asn Asn Arg Val 130 135 140 Cys Leu Leu Leu Val Ser Ser Ser Trp Phe Leu Gly Ser Val Asp Gly 145 150 155 160 Phe Met Ile Thr Pro Ile Thr Met Thr Leu Pro Val Cys Arg Ser Arg 165 170 175 Glu Ile Tyr His Phe Phe Cys Glu Val Pro Ala Val Met Lys Leu Ser 180 185 190

Page 2530

Cys Ser Asp 195 Thr Ser Leu Tyr 069269_0225_SL.TXT Glu Thr Phe Met Tyr Leu 200 205 Cys Cys Val Ile Ser Leu Leu Phe Pro Val Thr Val Ile Ser Ser Ser Tyr Ser Phe 210 215 220 Ile Leu Phe Thr Ile His Arg Met Lys Ser Ala Glu Gly Arg Lys Lys 225 230 235 240 Ala Phe Ala Thr Cys Ser Ser His Met Thr Val Val Val Leu Phe Tyr 245 250 255 Gly Ala Ala Val Tyr Thr Tyr Met Leu Pro Asn Thr Tyr His Thr Pro 260 265 270 Glu Lys Asp Leu Ile Val Ser Val Phe Tyr Thr Ile Leu Thr Pro Val 275 280 285 Leu His Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Arg Ala 290 295 300 Leu Lys Lys Met Leu Asn Val Lys Ser Val Ser Gln Glu Ser Ile Lys 305 310 315 320

<210> 2287 <211> 947 <212> DNA <213> Felis catus <400> 2287

tcatatattt tctaagtaag accatttctc attaccagtg ttctccaggc ccctttcaca 60 tctttgtttc tcagagtata gataatgggg tttaagactg gggtgactat ggtgtagaaa 120 agagagacaa acttaccctg tttttttgac ctacttttgg ccggctgaag gtacataaaa 180 atgatggtgc catagaaaat gatgaccaca atcaggtggg atgaacaagt cccaaaaacc 240 ttccagcgcc ctgctgctga ttttatcctc agcacagctt ttgttatgaa gccataggag 300 actaagatga gtgacactgg gacaactaga aaaatcacac tagccacaaa gagttctact 360 tcattgaaag ttgtgtccac acaggccagt ttgatgagca caggaacctc acagaaaatg 420

Page 2531

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tggtccagtt tgcgatgtcc acaaaggggt agctgaacag taagggagca ctggattaag 480 gaggtgatca gtccactgag ccatgctatg ctggctaggg atgcacagag ttgaggatgc 540 ataatggttg tatattgcag aggctggcag acagcagcat aacgatcata agccatgacc 600 gccaggagaa tacattcaga ggaacccaac cccatggcca catacagctg ggccacgcat 660 ccaccatagc tcacactttt ctctttctta ttcatggtaa ctagcaactg tggggcaaca 720 ctggtggtaa agcagatgtc cacacaagac agattgctga ggaaaaagta cattggcgtg 780 tggagtttgg ggactaaaca agatactaaa ataatggtag tgttccccag aatgttaaag 840 atgtacaaaa gcaaaattat gatgaaaagg atcctttcaa gccagggttc atctgcaaat 900 cccaggagaa gaaaaccctt ttcagagctg <210> 2288 <211> 311 <212> PRT <213> Felis catus <400> 2288 ttgctgcttt cctccat 947 Met Glu Glu Ser Ser Asn Ser Ser 1 5 Glu Lys Gly 10 Phe Leu Leu Leu Gly 15 Phe Ala Asp Glu Pro Trp Leu Glu 20 Arg Ile Leu 25 Phe Ile Ile 30 Ile Leu Leu Leu Tyr Ile Phe Asn Ile Leu 35 40 Gly Asn Thr Thr Ile Ile 45 Leu Val Ser Cys Leu Val Pro Lys Leu His 50 55 Thr Pro Met Tyr Phe Phe 60 Leu Ser Asn Leu Ser Cys Val Asp Ile Cys 65 70 Phe Thr Thr 75 Ser Val Ala Pro Gln 80 Leu Leu Val Thr Met Asn Lys Lys 85 Glu Lys Ser 90 Val Ser Tyr Gly Gly 95 Cys Val Ala Gln Leu Tyr Val Ala 100 Met Gly Leu 105 Gly Ser Ser 110 Glu Cys

Page 2532

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Ile Leu Leu 115 Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Gln 120 125 Pro Leu Gln Tyr Thr Thr Ile Met His Pro Gln Leu Cys Ala Ser Leu 130 135 140 Ala Ser Ile Ala Trp Leu Ser Gly Leu Ile Thr Ser Leu Ile Gln Cys 145 150 155 160 Ser Leu Thr Val Gln Leu Pro Leu Cys Gly His Arg Lys Leu Asp His 165 170 175 Ile Phe Cys Glu Val Pro Val Leu Ile Lys Leu Ala Cys Val Asp Thr 180 185 190 Thr Phe Asn Glu Val Glu Leu Phe Val Ala Ser Val Ile Phe Leu Val 195 200 205 Val Pro Val Ser Leu Ile Leu Val Ser Tyr Gly Phe Ile Thr Lys Ala 210 215 220 Val Leu Arg Ile Lys Ser Ala Ala Gly Arg Trp Lys Val Phe Gly Thr 225 230 235 240 Cys Ser Ser His Leu Ile Val Val Ile Ile Phe Tyr Gly Thr Ile Ile 245 250 255 Phe Met Tyr Leu Gln Pro Ala Lys Ser Arg Ser Lys Lys Gln Gly Lys 260 265 270 Phe Val Ser Leu Phe Tyr Thr Ile Val Thr Pro Val Leu Asn Pro Ile 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly Ala Trp Arg Thr Leu 290 295 300 Val Met Arg Asn Gly Leu Thr

305 310

Page 2533

069269_0225_SL.TXT <210> 2289 <211> 960 <212> DNA <213> Felis catus <400> 2289

ctactttata gtttcctgaa agacaaattc cacattcaac atttttttta gtgcctttgt 60 aacatcctta ttcctaagac tataaattaa agggtttaga acaggagtga gtatggtgta 120 aaagacagat acaatcatgt cattctcagg ggtgtggtag gaattgggga gcatgtaggt 180 atacacggca gccccataga agaggatgac aacagtcatg tgggaagaac aagtagcaaa 240 ggcctttttc tgcccctctg ctgacttcat cctgtggatg gtgaagagga tgaaagaata 300 ggagcttgaa atgactgtca caggaatgag gagcatgaga acgcaacata agtacataag 360 tgtctcatag atggaagtgt ctgagcagga aagcttcatt acagcaggga cttcacagaa 420 gaaatgatgg atctcccggg atctgcagaa agggaaggtc atggtgacgg gagtgagcat 480 aaatccatcc acagatccca gcaaccagca ggaagacacc aagatgaggc ataccctatg 540 gttcatgagg ataggataac ggagtggatg gcagatggcc acatagcggt cataggccat 600 ggcagctaga aggaaaaatt ctgaacctac cagtgtcaaa tagagaaaca tctgcatccc 660 acattcaggg gctgagatct tattcacacc cataacctgg tccatgagca tcttgggcac 720 aatgacagaa atgtacatca catccatgag agacaactga gtgataaaaa agtacatggg 780 gttatgaagg tgaacatcat agtgtatcaa aaggatcagc atggtgtttc cagacaaggc 840 catcaggaaa accacaaaaa tgaccacaca aagcagagat gggtgcttgg attgactgaa 900 gagtcccact agatcaaaat ctgatcgtac agtatggttg gcgacccaag tgttttccat 960

<210> 2290 <211> 319 <212> PRT <213> Felis catus <400> 2290

Met Glu Asn Thr Trp Val Ala Asn His Thr Val Arg Ser Asp Phe Asp

1 5 10 15

Leu Val Gly Leu Phe Ser Gln Ser Lys His Pro Ser Leu Leu Cys Val

20 25 30

Page 2534

069269_0225_SL.TXT

Val Ile Phe 35 Val Val Phe Leu Met Ala Leu Ser Gly Asn Thr Met Leu 40 45 Ile Leu Leu Ile His Tyr Asp Val His Leu His Asn Pro Met Tyr Phe 50 55 60 Phe Ile Thr Gln Leu Ser Leu Met Asp Val Met Tyr Ile Ser Val Ile 65 70 75 80 Val Pro Lys Met Leu Met Asp Gln Val Met Gly Val Asn Lys Ile Ser 85 90 95 Ala Pro Glu Cys Gly Met Gln Met Phe Leu Tyr Leu Thr Leu Val Gly 100 105 110 Ser Glu Phe Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Arg Tyr Pro Ile Leu Met Asn His Arg Val Cys 130 135 140 Leu Ile Leu Val Ser Ser Cys Trp Leu Leu Gly Ser Val Asp Gly Phe 145 150 155 160 Met Leu Thr Pro Val Thr Met Thr Phe Pro Phe Cys Arg Ser Arg Glu 165 170 175 Ile His His Phe Phe Cys Glu Val Pro Ala Val Met Lys Leu Ser Cys 180 185 190 Ser Asp Thr Ser Ile Tyr Glu Thr Leu Met Tyr Leu Cys Cys Val Leu 195 200 205 Met Leu Leu Ile Pro Val Thr Val Ile Ser Ser Ser Tyr Ser Phe Ile 210 215 220 Leu Phe Thr Ile His Arg Met Lys Ser Ala Glu Gly Gln Lys Lys Ala 225 230 235 240

Page 2535

069269_0225_SL.TXT

Phe Ala Thr Cys Ser 245 Ser His Met Ala Ala Val Tyr 260 Thr Tyr Met Leu Asn Asp Met 275 Ile Val Ser Val Phe 280 Asn Pro 290 Leu Ile Tyr Ser Leu 295 Arg Lys 305 Lys Met Leu Asn Val 310 Glu Phe

Thr Val 250 Val Ile Leu Phe Tyr 255 Gly Pro 265 Asn Ser Tyr His Thr 270 Pro Glu Tyr Thr Ile Leu Thr 285 Pro Val Leu Asn Lys Asp Val 300 Thr Lys Ala Leu Val Phe Gln 315 Glu Thr Ile Lys

<210> 2291 <211> 955 <212> DNA <213> Felis catus <400> 2291 ggagaacaac acttgggtgg ccaagcatac cttcagtcaa tccaagcacc caactctcct ggccttgact ggaaacatta tcctgatcct ccccatgtac tattttatca cccagttgtc tatgcccaag atgctcatgg accaggtcat tgggatgcag atgtttctct acttgacact catggcttat gaccactatg tggccatctg ccatagggtg tgtctcctcc tggtctcttc tatgctcacg cccatcacca tgacctcccc cttctgtgaa gcccctgctg taatgaagct actcatgtac ttatgttgtg ttctcatgct ctattctttc atcctcttca ccatccacag tcgacgatca gattttgacc tagtgggact ttgtgtggta atttttatgg atttcctgat tgtgatatgc catgatgccc accttgacaa tctcatggat gtgatgtaca tttctgtcac gggtgtgaat aagatctcag cccctgaatg agcaggttca gaagttttcc ttctagctgc ccatccactc tgttatccta tcctcatgaa ctcctggttt ctgggatctc tggatggatt cttctgcaga tcccaagaga tccatcattt ttcctgctca gatacttccc tctatgagac cctcatccct gtgacagtca tttcaagctc gatgaattca gaagaggggt ggaaaaggcc

120

180

240

300

360

420

480

540

600

660

720

Page 2536

069269_0225_SL.TXT tttgccactt gttcttccca catgaccatg gtaatcctct tctatgggac tgctgtctac acctacatgc tccccaattc ctaccacacc cctgagaatg acatgattgt atctgtcttt tataccatac tcactcctgt tctaaaccct ttaatttata gtcttaggaa taaggatgtc acaagggcac taaaaaaatg ttgaatgtag aatctgtcag gaaactataa agtag

780

840

900

955 <210> 2292 <211> 247 <212> PRT <213> Felis catus <400> 2292

Glu Asn Asn Thr Trp Val Ala Lys His Thr Arg Arg Ser Asp Phe Asp 1 5 10 15 Leu Val Gly Leu Phe Ser Gln Ser Lys His Pro Thr Leu Leu Cys Val 20 25 30 Val Ile Phe Met Asp Phe Leu Met Ala Leu Thr Gly Asn Ile Ile Leu 35 40 45 Ile Leu Val Ile Cys His Asp Ala His Leu Asp Asn Pro Met Tyr Tyr 50 55 60 Phe Ile Thr Gln Leu Ser Leu Met Asp Val Met Tyr Ile Ser Val Thr 65 70 75 80 Met Pro Lys Met Leu Met Asp Gln Val Met Gly Val Asn Lys Ile Ser 85 90 95 Ala Pro Glu Cys Gly Met Gln Met Phe Leu Tyr Leu Thr Leu Ala Gly 100 105 110 Ser Glu Val Phe Leu Leu Ala Ala Met Ala Tyr Asp His Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Cys Tyr Pro Ile Leu Met Asn His Arg Val Cys 130 135 140 Leu Leu Leu Val Ser Ser Ser Trp Phe Leu Gly Ser Leu Asp Gly Phe

Page 2537

0 6926 9_02 25_S L.TX T 145 150 155 160 Met Leu Thr Pro Ile Thr Met Thr Ser Pro Phe Cys Arg Ser Gln Glu 165 170 175 Ile His His Phe Phe Cys Glu Ala Pro Ala Val Met Lys Leu Ser Cys 180 185 190 Ser Asp Thr Ser Leu Tyr Glu Thr Leu Met Tyr Leu Cys Cys Val Leu 195 200 205 Met Leu Leu Ile Pro Val Thr Val Ile Ser Ser Ser Tyr Ser Phe Ile 210 215 220 Leu Phe Thr Ile His Arg Met Asn Ser Glu Glu Gly Trp Lys Arg Pro 225 230 235 240

Leu Pro Leu Val Leu Pro Thr 245

<210> 2293 <211> 942 <212> DNA <213> Felis catus <400> 2293 tgccaaaagc accagtgatg accaacaaga gtttcccaac tggcttcatt cttcttggtt 60 tctctgaatg gcctcatcta gaaatgcttc ttttctggat tgtgatcatc ttgtacacaa 120 tgatcatcct ctccaactca actattatct tgctttcttg tgtggaccct catctctaca 180 ctcccatgta cttctttctt agcaatcttt ccttcttgga tctctgcttt accacaacca 240 ctgttcccca tatgttgtcc aacttgtggg gacctggcaa gatcatcacc tacacaggct 300 gtgtcatcca actctgcatg ttactctgtc ttggtgccac agaatgtgtc atgttggtgg 360 tgatggcctt tgatcgttac attgctatct gccaacccct gcactatacc atcatcatgg 420 atcatcagtt ctgttggaag ctggtgctaa tagcctggat ctctggccta atagaatctg 480 ttacccagat tcctgtcaca cttcagcttc ccttctgcac ccaccaccgc ctagatgact 540 ttctctgtga ggttcctgcc ctcatacgct tgacatgtgg agacacctcg gccagtgagt 600

Page 2538

069269_0225_SL.TXT

ggcagatgac agtctctgct gttcttttca ccatcgtacc actggggttg atcctgactt 660 cttatggcta catagctcaa gctttaggta aaatccaatc caaggatggc agacagaaag 720 ccattgccac ctgctcctcc cacctcattg tggtctttat gttttatgga acagtggcac 780 cagtgtatac ataccctaag aatcactttg cttcaaatta tagcaagttc tttacattct 840 tctacactgc ggtcacacca ttgttaaatc cactcatcta ttccctaagg aacaaagatg 900 taaaaaatgc cctgatacaa ctgctaagaa gaggatcacc at 942

<210> 2294 <211> 309 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (309)..(309) <223> Any amino acid

<400> 2294 Phe Pro Thr Gly Phe Ile Leu Leu 10 Gly Phe 15 Ser Met Thr 1 Asn Lys Ser 5 Glu Trp Pro His Leu Glu Met Leu Leu Phe Trp Ile Val Ile Ile Leu 20 25 30 Tyr Thr Met Ile Ile Leu Ser Asn Ser Thr Ile Ile Leu Leu Ser Cys 35 40 45 Val Asp Pro His Leu Tyr Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Phe Leu Asp Leu Cys Phe Thr Thr Thr Thr Val Pro His Met Leu 65 70 75 80 Ser Asn Leu Trp Gly Pro Gly Lys Ile Ile Thr Tyr Thr Gly Cys Val 85 90 95 Ile Gln Leu Cys Met Leu Leu Cys Leu Gly Ala Thr Glu Cys Val Met 100 105 110

Page 2539

069269_0225_SL.TXT

Leu Val Val 115 Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Gln Pro Leu 120 125 His Tyr Thr Ile Ile Met Asp His Gln Phe Cys Trp Lys Leu Val Leu 130 135 140 Ile Ala Trp Ile Ser Gly Leu Ile Glu Ser Val Thr Gln Ile Pro Val 145 150 155 160 Thr Leu Gln Leu Pro Phe Cys Thr His His Arg Leu Asp Asp Phe Leu 165 170 175 Cys Glu Val Pro Ala Leu Ile Arg Leu Thr Cys Gly Asp Thr Ser Ala 180 185 190 Ser Glu Trp Gln Met Thr Val Ser Ala Val Leu Phe Thr Ile Val Pro 195 200 205 Leu Gly Leu Ile Leu Thr Ser Tyr Gly Tyr Ile Ala Gln Ala Leu Gly 210 215 220 Lys Ile Gln Ser Lys Asp Gly Arg Gln Lys Ala Ile Ala Thr Cys Ser 225 230 235 240 Ser His Leu Ile Val Val Phe Met Phe Tyr Gly Thr Val Ala Pro Val 245 250 255 Tyr Thr Tyr Pro Lys Asn His Phe Ala Ser Asn Tyr Ser Lys Phe Phe 260 265 270 Thr Phe Phe Tyr Thr Ala Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Leu Ile Gln Leu Leu Arg

290 295 300

Arg Gly Ser Pro Xaa 305

Page 2540

069269_0225_SL.TXT <210> 2295 <211> 879 <212> DNA <213> Felis catus <400> 2295

atgcacctgt tcctcttcag catggttgtg gtagtctaca cacttgccat ggctggcaac 60 actgccatgg ttttcctgat ctgggcagat gcccggctcc acacacccat gtatttcctc 120 ctcagccagc tgtcttttct ggacatcttc ttcacctcag tcaccatccc caagatgata 180 gcaggcttcc tctttggctg gactagcatc tcatttgtgg gctgtggagc acaaatgttt 240 ttcttcatgt tctttggggc cacagagtgc ctcctgctgg ccctcatggc ctatgaccgt 300 tacgtggcca tctgcaaccc tctgcgctac ccatcactca tgagtcatca gacctgtctg 360 ctcatggtgg ctgcctcctg gctgggaggg tctctcaatg cctccatcca gactgcactg 420 accctgcagt tcccctattg tggctcaaga aagattgcac actttttctg cgaggtgcct 480 tcactgctga ggctggtttg tgctgacaca gcctcctacg agcacgttct ttttgtgaca 540 ggtgtggtag tccttctgct gcccattgcc tttatcacta tgtcctatgc cctcatcttg 600 gcagcagtgc ttgggatgca ctctgtggag gggcgtcgga aggccctagc cacctgctcc 660 tcccacttaa cagttgtcaa cctcttctat ggacccctcg tctataccta tatgttacct 720 gcatcctacc actctcctgg ccaggatgat gtagtgtcca tcttctatac agtcctcaca 780 cccatgctga atcctgtcat ctacagtctc aggaacaagg aagtgacagg agcaatgaag 840 aatgtcatag ggaagtgtgg gatgggtaag attgcttaa 879

<210> 2296 <211> 292 <212> PRT <213> Felis catus <400> 2296

Met His Leu Phe Leu Phe Ser Met Val Val Val Val Tyr Thr Leu Ala 1 5 10 15

Met Ala Gly Asn Thr Ala Met Val Phe Leu Ile Trp Ala Asp Ala Arg 20 25 30

Page 2541

069269_0225_SL.TXT

Leu His Thr 35 Pro Met Tyr Phe Leu Leu Ser Gln Leu Ser Phe Leu Asp 40 45 Ile Phe Phe Thr Ser Val Thr Ile Pro Lys Met Ile Ala Gly Phe Leu 50 55 60 Phe Gly Trp Thr Ser Ile Ser Phe Val Gly Cys Gly Ala Gln Met Phe 65 70 75 80 Phe Phe Met Phe Phe Gly Ala Thr Glu Cys Leu Leu Leu Ala Leu Met 85 90 95 Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Pro Ser 100 105 110 Leu Met Ser His Gln Thr Cys Leu Leu Met Val Ala Ala Ser Trp Leu 115 120 125 Gly Gly Ser Leu Asn Ala Ser Ile Gln Thr Ala Leu Thr Leu Gln Phe 130 135 140 Pro Tyr Cys Gly Ser Arg Lys Ile Ala His Phe Phe Cys Glu Val Pro 145 150 155 160 Ser Leu Leu Arg Leu Val Cys Ala Asp Thr Ala Ser Tyr Glu His Val 165 170 175 Leu Phe Val Thr Gly Val Val Val Leu Leu Leu Pro Ile Ala Phe Ile 180 185 190 Thr Met Ser Tyr Ala Leu Ile Leu Ala Ala Val Leu Gly Met His Ser 195 200 205 Val Glu Gly Arg Arg Lys Ala Leu Ala Thr Cys Ser Ser His Leu Thr 210 215 220 Val Val Asn Leu Phe Tyr Gly Pro Leu Val Tyr Thr Tyr Met Leu Pro 225 230 235 240

Page 2542

069269_0225_SL.TXT

Ala Ser Tyr His Ser Pro Gly Gln Asp Asp Val Val Ser Ile Phe Tyr 245 250 255 Thr Val Leu Thr Pro Met Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn 260 265 270 Lys Glu Val Thr Gly Ala Met Lys Asn Val Ile Gly Lys Cys Gly Met

275 280 285

Gly Lys Ile Ala 290 <210> 2297 <211> 932 <212> DNA <213> Felis catus <400> 2297

atgaaaaatg ggaacaccac ctctgatttc attctcctag gactctttaa ccacacagga 60 acccatctat ttctctttgc aatggttctc acaattgcct tcgcctccct agtgggaaat 120 gccctcatga ttctcctgat tcaccaagat gcccggctcc acacacccat gtacttccta 180 ctgagccaac tctccctcat ggacatgatg ctggtctcta ccattgtgcc caaaatggct 240 actaactact tgactggaaa gatgtccatc tcccctgctg agtgcgggtt gcagatattc 300 ttccttctaa ctttaggagg gggtgagtgt ttcctcttag cagccatgtc ctatgaccgg 360 tatgtggctg tttgtcaccc actgcgatac ccagccctca tgagctggca attatgcctg 420 agaatgactg tggggtcttg ggtcctgggg gcagttgatg ggctcatgca ggctgctgct 480 accctgagtt ttccattttg cgatgcacat gagatcaatc atttcttctg tgaggcccct 540 actctggtgg gtttagcttg tgccgacacg tttgtctttg agtatgtgat gtacgtatgc 600 tgtgtgttaa tgctcctggt cccattttct ctcattctga tttcctatag tctcatcctt 660 gctgcagttc tccagatgca ttctagagaa gcccgcaaaa agccttttgc cacctgctcc 720 tcacatcttt ctgtggtggg actcttttat ggagctgcaa tttttaccta tatgcaaccc 780 aaatcctaca ggtcagctca ccatgataaa gtagtgtcag tgttctatac tatcttcacc 840 cctgtactca atcccctcat ctacagtctg agaaacagtg aagtcaaggg tgccttgaga 900

Page 2543

069269_0225_SL.TXT aagtgtatgg gtcagtgttc tgccttaagt ca

932 <210> 2298 <211> 311 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (311)..(311) <223> Any amino acid

<400> 2298 Asn Thr Thr Ser Asp Phe Ile Leu Leu Gly Leu Phe Met 1 Lys Asn Gly 5 10 15 Asn His Thr Gly Thr His Leu Phe Leu Phe Ala Met Val Leu Thr Ile 20 25 30 Ala Phe Ala Ser Leu Val Gly Asn Ala Leu Met Ile Leu Leu Ile His 35 40 45 Gln Asp Ala Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu 50 55 60 Ser Leu Met Asp Met Met Leu Val Ser Thr Ile Val Pro Lys Met Ala 65 70 75 80 Thr Asn Tyr Leu Thr Gly Lys Met Ser Ile Ser Pro Ala Glu Cys Gly 85 90 95 Leu Gln Ile Phe Phe Leu Leu Thr Leu Gly Gly Gly Glu Cys Phe Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Val Cys His Pro Leu 115 120 125 Arg Tyr Pro Ala Leu Met Ser Trp Gln Leu Cys Leu Arg Met Thr Val 130 135 140

Page 2544

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Gly 145 Ser Trp Val Leu Gly 150 Ala Val Asp Gly Leu Met Gln Ala Ala Ala 155 160 Thr Leu Ser Phe Pro Phe Cys Asp Ala His Glu Ile Asn His Phe Phe 165 170 175 Cys Glu Ala Pro Thr Leu Val Gly Leu Ala Cys Ala Asp Thr Phe Val 180 185 190 Phe Glu Tyr Val Met Tyr Val Cys Cys Val Leu Met Leu Leu Val Pro 195 200 205 Phe Ser Leu Ile Leu Ile Ser Tyr Ser Leu Ile Leu Ala Ala Val Leu 210 215 220 Gln Met His Ser Arg Glu Ala Arg Lys Lys Pro Phe Ala Thr Cys Ser 225 230 235 240 Ser His Leu Ser Val Val Gly Leu Phe Tyr Gly Ala Ala Ile Phe Thr 245 250 255 Tyr Met Gln Pro Lys Ser Tyr Arg Ser Ala His His Asp Lys Val Val 260 265 270 Ser Val Phe Tyr Thr Ile Phe Thr Pro Val Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Ser Glu Val Lys Gly Ala Leu Arg Lys Cys Met Gly 290 295 300 Gln Cys Ser Ala Leu Ser Xaa

305 310 <210> 2299 <211> 939 <212> DNA <213> Felis catus <400> 2299 ttagtcatgg cttaaggcag aacactgacc cagacatttt ctcagggcta acttgacttc

Page 2545

069269_0225_SL.TXT

tctgttcctc agactgtaga tgagggggtt cagtataggg gtgaagatag tatagaacac 120 tgaaactact ttatcatggt gagctgacct gtaggattta ggttgcatat aggtaaaaat 180 tgcagctccg taaaagagta ccaccacaga gagatgtgag gagcaggtgg taaaagcctt 240 tttgcgggct gatctaaaac gcatctggag aactgcagca aggatgagac tataggaaat 300 cagaatgaga gacaatggga ccaggagcat taacacacag catacgtaca tcacatactc 360 aaagacaaac gtgtccgcac aagctaaacg caccagagta ggggtctcac agaagaaatg 420 attgatctca tgtgcatcac aaaatggaaa actcagggta gcagcagcct gcatgagccc 480 atcagctgcc cccaggaccc aagaccccac agtcattctc aggcataatt gccagctcat 540 gagggctggg tatcgcagtg ggtgacaaac agccacatac cggtcatagg acatggctgc 600 taagaggaag cactcgcccc ctcccaaagt gataaaaaag aagatctgca acccacagcc 660 ggcaagggag attaacttct ctccagtcaa gtagtcagta accattttgg gcacaatggt 720 ggaaaccagc atcatgtcca tgagggagag ttgactcagt aggaagtaca tgggtgtgtg 780 gagtcgggca tcttgatgaa tcaagaagat catgaaggca ttgcccacta gggaggcgaa 840 ggaagttgtc acaaccatca caaaaagaaa tagtttggct tctgtgtggt taaagagtcc 900 taggagaatg aaatatgagg tggtgttccc gtttttcat 939

<210> 2300 <211> 312 <212> PRT <213> Felis catus <400> 2300

Met 1 Lys Asn Gly Asn 5 Thr Thr Ser Tyr Phe Ile Leu Leu Gly 10 Leu 15 Phe Asn His Thr Glu Ala Lys Leu Phe Leu Phe Val Met Val Val Thr Thr 20 25 30 Ser Phe Ala Ser Leu Val Gly Asn Ala Phe Met Ile Phe Leu Ile His 35 40 45 Gln Asp Ala Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu 50 55 60

Page 2546

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Ser Leu 65 Met Asp Met Met 70 Leu Val Ser Thr Ile Val Pro Lys Met Val 75 80 Thr Asp Tyr Leu Thr Gly Glu Lys Leu Ile Ser Leu Ala Gly Cys Gly 85 90 95 Leu Gln Ile Phe Phe Phe Ile Thr Leu Gly Gly Gly Glu Cys Phe Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Val Cys His Pro Leu 115 120 125 Arg Tyr Pro Ala Leu Met Ser Trp Gln Leu Cys Leu Arg Met Thr Val 130 135 140 Gly Ser Trp Val Leu Gly Ala Ala Asp Gly Leu Met Gln Ala Ala Ala 145 150 155 160 Thr Leu Ser Phe Pro Phe Cys Asp Ala His Glu Ile Asn His Phe Phe 165 170 175 Cys Glu Thr Pro Thr Leu Val Arg Leu Ala Cys Ala Asp Thr Phe Val 180 185 190 Phe Glu Tyr Val Met Tyr Val Cys Cys Val Leu Met Leu Leu Val Pro 195 200 205 Leu Ser Leu Ile Leu Ile Ser Tyr Ser Leu Ile Leu Ala Ala Val Leu 210 215 220 Gln Met Arg Phe Arg Ser Ala Arg Lys Lys Ala Phe Thr Thr Cys Ser 225 230 235 240 Ser His Leu Ser Val Val Val Leu Phe Tyr Gly Ala Ala Ile Phe Thr 245 250 255 Tyr Met Gln Pro Lys Ser Tyr Arg Ser Ala His His Asp Lys Val Val 260 265 270

Page 2547

069269_0225_SL.TXT

Ser Val Phe Tyr Thr Ile Phe Thr Pro Ile Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Arg Glu Val Lys Leu Ala Leu Arg Lys Cys Leu Gly 290 295 300 Gln Cys Ser Ala Leu Ser His Asp 305 310

<210> 2301 <211> 966 <212> DNA <213> Felis catus <400> 2301

tcattgaagc atggaaacct gttttgatgg ggcacttttc aaacaccttc atcattgtgc 60 ccacaacctc ccactttttt agactgcaga tgagggggtt aagtatagga gtgaggatgg 120 tgtcaaacat aaagagaacc tggttcagga tgaaggtgtg ggaagatcaa ggcctcattt 180 atatcagcat gcatggacca aagtaaatga taagcaccat cagatggaag gagcaagtag 240 tcagggcctt gatcctgcat tcacaggtgt ttatttgcaa gacgtgcagg aagatgagga 300 tgatggaggt cagggtaaag cttttgggaa gaagaaccac aacaatatgg atcactacta 360 tcactttctc ataggctgag atgtcctcac aaaacagttt caagatgtca aagacctctc 420 aacaatacct cacagaagaa caggtggagt tctcaggggc taaagagaag aaagttcatg 480 gcataaatgg cacagaccaa ggatgccaga gtccctccca cccaggtccc aaagaccata 540 ttctggaaga cctgtagaca ggtataactg ggtatctgaa tggattgctg gtggccacat 600 cgaatcataa tccatgagac tcaagagaag agtaggcact tagtaatccc aagagtcaag 660 gtgaagagga cctgggtccc agagttgatc aatggtactt ttcttttacc taagaaaaag 720 atgaccaata tttttggaag tatgctaaag atgaaaaccg ggtcaatgag tgagttgtca 780 aatcagtaaa tacatggagg tgtggaagtg gggatctgac aagatgagga ggatcaaaac 840 agtgtttcct gtgatagcaa aagtgtagat gaggaggaca acagagacaa ggaggtcagt 900 atgtctcatt ccagggaaga agcccaggag aatgaagtct gtgcccaatg tctcatttcc 960

tttctc 966

Page 2548

069269_0225_SL.TXT <210> 2302 <211> 67 <212> PRT <213> Felis catus

<400> 2302 Pro Val Leu Met Gly His Phe Ser Asn Thr Phe Ile 1 Glu Ala Trp Lys 5 10 15 Ile Ile Val Pro Thr Thr Ser His Phe Phe Arg Leu Gln Met Arg Gly 20 25 30 Leu Ser Ile Gly Val Arg Met Val Ser Asn Ile Lys Arg Thr Trp Phe 35 40 45 Arg Met Lys Val Trp Glu Asp Gln Gly Leu Ile Tyr Ile Ser Met His 50 55 60

Gly Pro Lys 65 <210> 2303 <211> 945 <212> DNA <213> Felis catus <400> 2303

tttcaccttt ttcaggaagc atctactaat gactatactc ttcatagctg ctattacatc 60 cttgtttctc aggctataga tgagagggtt aagcataggg gtaagaatag cattaaacat 120 aaagagggac tggtttattt tgggggtctt aaaggatcct ggcctcatgt agactaatac 180 agcaggacca aagtaaaggc tgaccacaca gagatgggag aagcatgtgg ccaaggcctt 240 gttcttgcct tcaggggaat tcatgtggac aacagcaagg aatatacgga tataggaagc 300 caggataaga ctcagaggga tgaggaccac cagaaagctt gagaccacca ctgaatttac 360 ataggctgaa atgtcctcac aagtgagctt caggagtgcc atgacctcac acaagaagtg 420 tgggatctct cgaggatgac agatgggtaa gtgcatgaca taagctgtat gaaccagtga 480 agttattgcc cctccgaccc aggacacaat gaccatctgt ttacaaatgg tatggctcat 540

Page 2549

069269_0225_SL.TXT

catgactgaa taacgcagtg gattgcagat ggcaatgtag cggtcatagg acatgagggt 600 aagcagaagg cactcagaaa ttcccaaggt taagctgaat aagatctggg atccacaacc 660 aatctgtgat atggttctct tccctgagaa gaaatttgtg gccattttgg ggacagtagt 720 tgagatcaga gccacatcaa taagggaaag ctgactgagc aggaagtaca taggacagtg 780 gagtcgagaa tccagccaga tgaggagaat gagaacagca ttgcctatca cagccataat 840 atagaccaga agaatgagga agataaggat cacaaggtgg ctgaactcag gccagagccc 900 caaaagaata aaatctgtgg tgacagtctt attgtttttc tccat 945

<210> 2304 <211> 315 <212> PRT <213> Felis catus <400> 2304

Met Glu Lys Asn Asn Lys Thr Val Thr Thr Asp Phe Ile Leu Leu Gly 1 5 10 15 Leu Trp Pro Glu Phe Ser His Leu Val Ile Leu Ile Phe Leu Ile Leu 20 25 30 Leu Val Tyr Ile Met Ala Val Ile Gly Asn Ala Val Leu Ile Leu Leu 35 40 45 Ile Trp Leu Asp Ser Arg Leu His Cys Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Leu Ile Asp Val Ala Leu Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Ala Thr Asn Phe Phe Ser Gly Lys Arg Thr Ile Ser Gln Ile Gly 85 90 95 Cys Gly Ser Gln Ile Leu Phe Ser Leu Thr Leu Gly Ile Ser Glu Cys 100 105 110 Leu Leu Leu Thr Leu Met Ser Tyr Asp Arg Tyr Ile Ala Ile Cys Asn 115 120 125

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Pro Leu Arg Tyr 130 Ser Val Met 135 Met Ser His Thr Ile 140 Cys Lys Gln Met Val Ile Val Ser Trp Val Gly Gly Ala Ile Thr Ser Leu Val His Thr 145 150 155 160 Ala Tyr Val Met His Leu Pro Ile Cys His Pro Arg Glu Ile Pro His 165 170 175 Phe Leu Cys Glu Val Met Ala Leu Leu Lys Leu Thr Cys Glu Asp Ile 180 185 190 Ser Ala Tyr Val Asn Ser Val Val Val Ser Ser Phe Leu Val Val Leu 195 200 205 Ile Pro Leu Ser Leu Ile Leu Ala Ser Tyr Ile Arg Ile Phe Leu Ala 210 215 220 Val Val His Met Asn Ser Pro Glu Gly Lys Asn Lys Ala Leu Ala Thr 225 230 235 240 Cys Phe Ser His Leu Cys Val Val Ser Leu Tyr Phe Gly Pro Ala Val 245 250 255 Leu Val Tyr Met Arg Pro Gly Ser Phe Lys Thr Pro Lys Ile Asn Gln 260 265 270 Ser Leu Phe Met Phe Asn Ala Ile Leu Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Ile Ala Ala Met Lys Ser Ile 290 295 300 Val Ile Ser Arg Cys Phe Leu Lys Lys Val Lys 305 310 315

<210> 2305 <211> 929 <212> DNA

Page 2551

069269_0225_SL.TXT <213> Felis catus <400> 2305

ttacctggag gactgacacc gccccattaa ctttttcagt gcacttagaa cttccttgtt 60 cctgagactg taggcaagag ggtttaggag aggggtgagg acagttccaa acagaaaaag 120 accctgattt aactttggag tcttggcaga accaggtctc atgtatatgc acaaacctgg 180 accaaaatag agacccacca cacagagatg agaggagcag gtggccagag ccttgttcct 240 cccttctggg gagttcattc ggagtacagc aaggaagatg agaacataag aagacaaaat 300 gagagataag ggcaggagca gaacaaggat gcttgttatc accactgcct tctcataggc 360 tgagatatcc tcacagacga tcctaagcac agccataact tcacagaaga agtggggaat 420 ttctctgggg ctgcagatat taaaatgcaa ggtaaaagcc gtgtggccca aggaagtaag 480 tgcccctcca acccaagaca tagcaatcat ctgtaagcat accctaagat ttataatggc 540 tgggtaccga agaggatcgc atatggctac ataacgatca aaacacatga gcgttataag 600 gatgcattcc gcaatggcca cagtcaggga gaagaaaatt tgagtcccac aagccaagaa 660 tgatatgctc cgccatccag agaagaagtt ggtggccatc ttggggatga tgctagaggt 720 caaagttaag tccattaagg agagctgact gagcaggaag tacatggggg tgtggagatg 780 ggagtacaac caaatgagga ggatcagaag agtattgcca gtgaaggttg ccatgtagat 840 caggagaatg atggagacca tggctgaaat gtatttaaat tcagggaaga agcccaggag 900 gatgaaatct gtgggttttg tctcattcc 929

<210> 2306 <211> 308 <212> PRT <213> Felis catus

<400> 2306 Thr Asp Phe Ile Leu Leu Gly Phe Phe Pro Glu Asn 1 Glu Thr Lys Pro 5 10 15 Phe Lys Tyr Ile Ser Ala Met Val Ser Ile Ile Leu Leu Ile Tyr Met 20 25 30 Ala Thr Phe Thr Gly Asn Thr Leu Leu Ile Leu Leu Ile Trp Leu Tyr 35 40 45

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Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu Ser Leu 50 55 60 Met Asp Leu Thr Leu Thr Ser Ser Ile Ile Pro Lys Met Ala Thr Asn 65 70 75 80 Phe Phe Ser Gly Trp Arg Ser Ile Ser Phe Leu Ala Cys Gly Thr Gln 85 90 95 Ile Phe Phe Ser Leu Thr Val Ala Ile Ala Glu Cys Ile Leu Ile Thr 100 105 110 Leu Met Cys Phe Asp Arg Tyr Val Ala Ile Cys Asp Pro Leu Arg Tyr 115 120 125 Pro Ala Ile Ile Asn Leu Arg Val Cys Leu Gln Met Ile Ala Met Ser 130 135 140 Trp Val Gly Gly Ala Leu Thr Ser Leu Gly His Thr Ala Phe Thr Leu 145 150 155 160 His Phe Asn Ile Cys Ser Pro Arg Glu Ile Pro His Phe Phe Cys Glu 165 170 175 Val Met Ala Val Leu Arg Ile Val Cys Glu Asp Ile Ser Ala Tyr Glu 180 185 190 Lys Ala Val Val Ile Thr Ser Ile Leu Val Leu Leu Leu Pro Leu Ser 195 200 205 Leu Ile Leu Ser Ser Tyr Val Leu Ile Phe Leu Ala Val Leu Arg Met 210 215 220 Asn Ser Pro Glu Gly Arg Asn Lys Ala Leu Ala Thr Cys Ser Ser His 225 230 235 240 Leu Cys Val Val Gly Leu Tyr Phe Gly Pro Gly Leu Cys Ile Tyr Met 245 250 255

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Arg Pro Gly Ser Ala Lys Thr Pro Lys Leu Asn Gln Gly Leu 270 Phe Leu 260 265 Phe Gly Thr Val Leu Thr Pro Leu Leu Asn Pro Leu Ala Tyr Ser Leu 275 280 285 Arg Asn Lys Glu Val Leu Ser Ala Leu Lys Lys Leu Met Gly Arg Cys

290 295 300

Gln Ser Ser Arg 305 <210> 2307 <211> 825 <212> DNA <213> Felis catus <400> 2307 atggtgggtg gaaacaaatc ctcaataacc gatttcatcc ttgtcggact ctttcctgaa 60 tttcagcatt ctattgtcct caactttatg atcatctttg tctacattct tgccttcctg 120 ggaaacatac ttttgattgt cttaatttgg ggagactctc gacttcatac gcccatgtac 180 attctcctca gtcaactctc cctcattgac ttgacattaa cttccaccat tgttccaaag 240 atggcttcta actattttac tgggaaaaga accatatcat ggattggctg tggaacacag 300 agtttcttct tcctgatgtt gggaatgtca gaatgcctca tcttgactct catggcttat 360 gaccgctatg tggctgtctg caacccattg cgttatccca ttattatgag ccccaggttc 420 tgtatgcaca tggttttagg ttgttggatt ggaggctcta taagttcatt tatccataca 480 gtctacccta tgcattttcc catctgtggg tcacgggaga tccaccactt cttctgtgag 540 gtcccagtcc tcattaagct ctcctgtgaa gacacttcag tgtaccagtt agtggtggtg 600 gtgacaagca ttgtgttgct tgttgtacct ttcagtctca tcacagtttc ctatactctc 660 atcttcctca ctgtatttcg tatgaactct gtcaaaggca ggaaaaaaac tctggccact 720 tgttcttccc atctaactgt ggtgagtctc ttctttggcc caaacatatt tatctatatg 780 actttcactt cctcccatag tgcagagcag gaccaagctc tttct 825

Page 2554

069269_0225_SL.TXT <210> 2308 <211> 275 <212> PRT <213> Felis catus

<400> 2308 Met 1 Val Gly Gly Asn Lys 5 Ser Ser Ile Thr 10 Asp Phe Ile Leu Val 15 Gly Leu Phe Pro Glu Phe Gln His Ser Ile Val Leu Asn Phe Met Ile Ile 20 25 30 Phe Val Tyr Ile Leu Ala Phe Leu Gly Asn Ile Leu Leu Ile Val Leu 35 40 45 Ile Trp Gly Asp Ser Arg Leu His Thr Pro Met Tyr Ile Leu Leu Ser 50 55 60 Gln Leu Ser Leu Ile Asp Leu Thr Leu Thr Ser Thr Ile Val Pro Lys 65 70 75 80 Met Ala Ser Asn Tyr Phe Thr Gly Lys Arg Thr Ile Ser Trp Ile Gly 85 90 95 Cys Gly Thr Gln Ser Phe Phe Phe Leu Met Leu Gly Met Ser Glu Cys 100 105 110 Leu Ile Leu Thr Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Ile Ile Met Ser Pro Arg Phe Cys Met His Met 130 135 140 Val Leu Gly Cys Trp Ile Gly Gly Ser Ile Ser Ser Phe Ile His Thr 145 150 155 160 Val Tyr Pro Met His Phe Pro Ile Cys Gly Ser Arg Glu Ile His His 165 170 175 Phe Phe Cys Glu Val Pro Val Leu Ile Lys Leu Ser Cys Glu Asp Thr

Page 2555

180

069269_0225_SL.TXT 185 190

Ser Val Tyr 195 Gln Leu Val Val Val Val Thr Ser Ile Val Leu Leu Val 200 205 Val Pro Phe Ser Leu Ile Thr Val Ser Tyr Thr Leu Ile Phe Leu Thr 210 215 220 Val Phe Arg Met Asn Ser Val Lys Gly Arg Lys Lys Thr Leu Ala Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Ser Leu Phe Phe Gly Pro Asn Ile 245 250 255 Phe Ile Tyr Met Thr Phe Thr Ser Ser His Ser Ala Glu Gln Asp Gln 260 265 270

Ala Leu Ser 275 <210> 2309 <211> 831 <212> DNA <213> Felis catus <400> 2309

aatggtgttc agcactgtgg caaatttgtt aacatccatc acatcaccct tttttgggcg 60 gacgtaaata aagatggagc ttccataata aagtgtcaca acagtgatgt gtgaaacaca 120 agtggagaaa gctttctgcc gtccctggtc aaaaggaatt ctaaggatag caataataat 180 gtacatgtaa gacactcctg tgaagagcaa ggagcccaag agcaacacag cagaggagat 240 aaagtcagcc agctcagcca gagcgatatc tgcacagacc agctttagca cagggccact 300 gtcacaaaag aagtgattga taatatttgg tccacaaaag ggcagaggag cagttaagat 360 tgatggtgct aaaattgaca aaaatgcacc taaataggat cccagaagca acaatatgca 420 tgtctgtttg ttcatgatga tggcatacct caatgggttg cagatggcaa tgtatcgatc 480 atatgacatg acgaccagga tgaagaattc cgtggatccc aagaggaagt aaaagaaaga 540 ttgcgtgaga catcccataa aggatattgc tttggtgagg gaaaatgtgt ttgctagcat 600

Page 2556

069269_0225_SL.TXT cttaggcacc actgtggagg tgatggcgac ttcaaggaag gaaagattgg ctacaaagaa atacatgggt gaatgcagac ggtagtcacc acacaccaaa aggatgatca tggtgttgcc aatcagagac gtcatataca tgagcaagaa tgcagaaaaa agaagaattt ctacttcctt ctcattctga aaccccagaa gaataaactc agtgactgcg gtcttgtttc t

660

720

780

831 <210> 2310 <211> 277 <212> PRT <213> Felis catus <400> 2310

Arg Asn Lys Thr 1 Ala 5 Val Thr Glu Phe Ile Leu Leu Gly Phe Gln Asn 10 15 Glu Lys Glu Val Glu Ile Leu Leu Phe Ser Ala Phe Leu Leu Met Tyr 20 25 30 Met Thr Ser Leu Ile Gly Asn Thr Met Ile Ile Leu Leu Val Cys Gly 35 40 45 Asp Tyr Arg Leu His Ser Pro Met Tyr Phe Phe Val Ala Asn Leu Ser 50 55 60 Phe Leu Glu Val Ala Ile Thr Ser Thr Val Val Pro Lys Met Leu Ala 65 70 75 80 Asn Thr Phe Ser Leu Thr Lys Ala Ile Ser Phe Met Gly Cys Leu Thr 85 90 95 Gln Ser Phe Phe Tyr Phe Leu Leu Gly Ser Thr Glu Phe Phe Ile Leu 100 105 110 Val Val Met Ser Tyr Asp Arg Tyr Ile Ala Ile Cys Asn Pro Leu Arg 115 120 125 Tyr Ala Ile Ile Met Asn Lys Gln Thr Cys Ile Leu Leu Leu Leu Gly 130 135 140

Page 2557

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Ser Tyr Leu Gly Ala Phe Leu Ser Ile Leu Ala Pro Ser Ile Leu Thr 145 150 155 160 Ala Pro Leu Pro Phe Cys Gly Pro Asn Ile Ile Asn His Phe Phe Cys 165 170 175 Asp Ser Gly Pro Val Leu Lys Leu Val Cys Ala Asp Ile Ala Leu Ala 180 185 190 Glu Leu Ala Asp Phe Ile Ser Ser Ala Val Leu Leu Leu Gly Ser Leu 195 200 205 Leu Phe Thr Gly Val Ser Tyr Met Tyr Ile Ile Ile Ala Ile Leu Arg 210 215 220 Ile Pro Phe Asp Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys Val Ser 225 230 235 240 His Ile Thr Val Val Thr Leu Tyr Tyr Gly Ser Ser Ile Phe Ile Tyr 245 250 255 Val Arg Pro Lys Lys Gly Asp Val Met Asp Val Asn Lys Phe Ala Thr 260 265 270 Val Leu Asn Thr Ile

275 <210> 2311 <211> 831 <212> DNA <213> Felis catus <400> 2311 agaaacaaga ccagagtcat ggagtttatt cttctggggt ttcagaatga aaaggaagta gaaattcttc ttttttatgc attcttgctc atgtacatga cgtctctgat tggcaacacc atgatcgtcc ttttggtgtg tggtgactac catctgcatt cactcatgta tttctttgta gccaatcttt ccttccttga agttgccatg acctccacag tggtgcctaa gatgctggca aacatatttt ccctcaccaa ggcaatatcc ttcataggat gtctcacaca gtctttcttc

120

180

240

300

Page 2558

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tacttcttct tgggatccac ggaatccttc atcctggtcg tcatgtcata tgatcgatac 360 attgccatct gcaacccatt gaggtatgcc atcatcatga acaaacagac atgcatattg 420 ttgcttctgg gatcctattt aggtgcattt ttgtcaattt tagcaccatc aatcttaact 480 gctcctctgc ccttttgtgg accaaatatt atcaatcact tcttttgtga cagtggccct 540 gtgctaaagc tggtctgtgc agatatcgct ctggctgagc tggctgactt tatctcctct 600 gctgtgttgc tcttgggctc cttgctcttc acaggagtgt cttacatgta cattattatt 660 gctatcctta gaattccttc tgtccagtga cagcagaaag ctttctccac ttgtgtttca 720 cacatcactg ttgtgacact ttattatgga agctccatct ttatttacgt ccgcccaaaa 780 aagggtgatg tgatggatgt taacaaattt gccacagtgc tgaacaccat t 831

<210> 2312 <211> 229 <212> PRT <213> Felis catus

<400> 2312 Val Met Glu Phe Ile Leu Leu Gly Phe Gln Asn Arg Asn 1 Lys Thr Arg 5 10 15 Glu Lys Glu Val Glu Ile Leu Leu Phe Tyr Ala Phe Leu Leu Met Tyr 20 25 30 Met Thr Ser Leu Ile Gly Asn Thr Met Ile Val Leu Leu Val Cys Gly 35 40 45 Asp Tyr His Leu His Ser Leu Met Tyr Phe Phe Val Ala Asn Leu Ser 50 55 60 Phe Leu Glu Val Ala Met Thr Ser Thr Val Val Pro Lys Met Leu Ala 65 70 75 80 Asn Ile Phe Ser Leu Thr Lys Ala Ile Ser Phe Ile Gly Cys Leu Thr 85 90 95 Gln Ser Phe Phe Tyr Phe Phe Leu Gly Ser Thr Glu Ser Phe Ile Leu 100 105 110

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Val Val Met Ser Tyr Asp Arg Tyr Ile Ala Ile Cys Asn Pro Leu Arg 115 120 125 Tyr Ala Ile Ile Met Asn Lys Gln Thr Cys Ile Leu Leu Leu Leu Gly 130 135 140 Ser Tyr Leu Gly Ala Phe Leu Ser Ile Leu Ala Pro Ser Ile Leu Thr 145 150 155 160 Ala Pro Leu Pro Phe Cys Gly Pro Asn Ile Ile Asn His Phe Phe Cys 165 170 175 Asp Ser Gly Pro Val Leu Lys Leu Val Cys Ala Asp Ile Ala Leu Ala 180 185 190 Glu Leu Ala Asp Phe Ile Ser Ser Ala Val Leu Leu Leu Gly Ser Leu 195 200 205 Leu Phe Thr Gly Val Ser Tyr Met Tyr Ile Ile Ile Ala Ile Leu Arg 210 215 220 Ile Pro Ser Val Gln

225 <210> 2313 <211> 972 <212> DNA <213> Felis catus <400> 2313

ttacctaata aagaaactgc ccttcacttt tcctccatag atatcacact tttttctcat 60 gagttttcta acagcctctt tgaattcttg attcctcaag ctgtagataa tagggttcag 120 aagtggggtg accacagtgt agaagacaga aataatcttg ttgatttcag gtgacaggtg 180 gtcattgggg cgaacataca tggagatcat ggtgccatag tagatagtga caacagccaa 240 atgggagcca catgtggaaa aggtcttcat ccagccagag cctgaaggaa ttctcaatat 300 ggtggacaca atgaaaacat aggatacaag tgtgagaaaa aagcaaatgc acaacactgc 360 aattgacaga ataaagatga ccatcctggt gatatacaca ctggaacatg agagctgcat 420

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gaggggaggg aggtcacaga agaaatgatt gatctggtta ggcccacaga aatccaactt 480 ggaaatcatt agggagggca gaagccctgt gccaacacct gtcaaccagg agattgccac 540 taacttggtg cagatctcag gactcatcaa ggaagagtac tggagtgggc tgtagatggc 600 cagatatcgg tcataggcca tcatggccag aagaaaacac tcagtagctc caaagaacac 660 aaagaagtaa agctgtgtca tacaggtgga gaaggagatg acttgtccat gggagaacag 720 gttggctagg agaaggggca caatagtgaa tgtatagcag atctccagaa aggagaggtg 780 tttgagaaat atgtacatag gcaagcggag tcgctggtcc tggctcacca ctgtaataat 840 gacaacattt cctgttactg tgagaaagta gatgaacaag aagacggcaa agagtagtgt 900 ctgccattca agaaggttct ggaatcctaa aagctgaaac tcagtgacac tggacacatt 960 tagaggcttc at 972

<210> 2314 <211> 323 <212> PRT <213> Felis catus <400> 2314

Met 1 Lys Pro Leu Asn Val 5 Ser Ser Val Thr Glu Phe Gln Leu Leu Gly 10 15 Phe Gln Asn Leu Leu Glu Trp Gln Thr Leu Leu Phe Ala Val Phe Leu 20 25 30 Phe Ile Tyr Phe Leu Thr Val Thr Gly Asn Val Val Ile Ile Thr Val 35 40 45 Val Ser Gln Asp Gln Arg Leu Arg Leu Pro Met Tyr Ile Phe Leu Lys 50 55 60 His Leu Ser Phe Leu Glu Ile Cys Tyr Thr Phe Thr Ile Val Pro Leu 65 70 75 80 Leu Leu Ala Asn Leu Phe Ser His Gly Gln Val Ile Ser Phe Ser Thr 85 90 95

Page 2561

Cys Met Thr Gln 100 Leu Tyr Phe 069269_0225_SL.TXT Phe Val Phe Phe Gly Ala 105 Thr 110 Glu Cys Phe Leu Leu Ala Met Met Ala Tyr Asp Arg Tyr Leu Ala Ile Tyr Ser 115 120 125 Pro Leu Gln Tyr Ser Ser Leu Met Ser Pro Glu Ile Cys Thr Lys Leu 130 135 140 Val Ala Ile Ser Trp Leu Thr Gly Val Gly Thr Gly Leu Leu Pro Ser 145 150 155 160 Leu Met Ile Ser Lys Leu Asp Phe Cys Gly Pro Asn Gln Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Pro Pro Leu Met Gln Leu Ser Cys Ser Ser Val 180 185 190 Tyr Ile Thr Arg Met Val Ile Phe Ile Leu Ser Ile Ala Val Leu Cys 195 200 205 Ile Cys Phe Phe Leu Thr Leu Val Ser Tyr Val Phe Ile Val Ser Thr 210 215 220 Ile Leu Arg Ile Pro Ser Gly Ser Gly Trp Met Lys Thr Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ala Val Val Thr Ile Tyr Tyr Gly Thr Met Ile 245 250 255 Ser Met Tyr Val Arg Pro Asn Asp His Leu Ser Pro Glu Ile Asn Lys 260 265 270 Ile Ile Ser Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Phe Lys Glu Ala Val Arg Lys Leu 290 295 300

Page 2562

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Met Arg Lys Lys Cys Asp Ile Tyr Gly Gly Lys Val Lys Gly Ser Phe 305 310 315 320

Phe Ile Arg <210> 2315 <211> 939 <212> DNA <213> Felis catus <400> 2315

atggatggga ccaatgacag cacccaggga aatttcatcc ttttggggtt ttctaaccat 60 ccccatctcg agaggatcct ctttgtggtc atcttgattg catacctcct gactcttatg 120 ggcaacacca ccatcatcct ggtgtcccgg ctggaccccc acctccacac tcctatgtac 180 ttcttcctca cccacctatc tttcctggac ctcagtttca ccaccagctc cattcctcag 240 ctgctctata acctgaatgg ccatgacaag accatcagtt acacaggctg tgccatccag 300 ctcttcctgt ttctgggtct aggtggcgtg gagtgcttgc tcctggctgt catggcatat 360 gaccggtttg ttgcagtctg caaacccctg cactacctgg tgatcatgaa tccacgtctc 420 tgcatgggct tagtgttggt ggcctggggc tgtggtgtgg ctaactcctt ggtcatgtcc 480 ccagtcaccc tgcagttacc ccgctgtggg cgccacagtg tggaccactt cctgtgtgag 540 atgcctgccc tgattcggat ggcctgtgtc aatacagctg ccattgaagg cactgtcttt 600 gtcctggcag tgggcattgt gctgtcacct ctagtgttta tcctggtgtc ctacggctac 660 attgtaaggg ctgtgttaca gattcaacca gtgtcaggga gacaaaaggc gtttaacacc 720 tgtggctccc atctcacagt ggtctccctt ttctatggaa atatcatcta catgtacatg 780 caacctggaa acagctcttc ccaggaccag agcaaattcc tcaccctctt ctacaacatt 840 gtcacaccac tcctgaaccc cctgatttac accctccgaa acaaagaggt gaagggggca 900 ctgaggagaa tgctgctgga taacagaggg gtaggaaag 939

<210> 2316 <211> 313 <212> PRT <213> Felis catus

Page 2563

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<400> 2316 Asn Asp Ser Thr Gln Gly Asn Phe Ile Leu Leu 15 Gly Met 1 Asp Gly Thr 5 10 Phe Ser Asn His Pro His Leu Glu Arg Ile Leu Phe Val Val Ile Leu 20 25 30 Ile Ala Tyr Leu Leu Thr Leu Met Gly Asn Thr Thr Ile Ile Leu Val 35 40 45 Ser Arg Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 His Leu Ser Phe Leu Asp Leu Ser Phe Thr Thr Ser Ser Ile Pro Gln 65 70 75 80 Leu Leu Tyr Asn Leu Asn Gly His Asp Lys Thr Ile Ser Tyr Thr Gly 85 90 95 Cys Ala Ile Gln Leu Phe Leu Phe Leu Gly Leu Gly Gly Val Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Leu Val Ile Met Asn Pro Arg Leu Cys Met Gly Leu 130 135 140 Val Leu Val Ala Trp Gly Cys Gly Val Ala Asn Ser Leu Val Met Ser 145 150 155 160 Pro Val Thr Leu Gln Leu Pro Arg Cys Gly Arg His Ser Val Asp His 165 170 175 Phe Leu Cys Glu Met Pro Ala Leu Ile Arg Met Ala Cys Val Asn Thr 180 185 190 Ala Ala Ile Glu Gly Thr Val Phe Val Leu Ala Val Gly Ile Val Leu 195 200 205

Page 2564

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Ser Pro Leu Val Phe Ile Leu Val Ser Tyr Gly Tyr Ile Val Arg Ala 210 215 220 Val Leu Gln Ile Gln Pro Val Ser Gly Arg Gln Lys Ala Phe Asn Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Asn Ile Ile 245 250 255 Tyr Met Tyr Met Gln Pro Gly Asn Ser Ser Ser Gln Asp Gln Ser Lys 260 265 270 Phe Leu Thr Leu Phe Tyr Asn Ile Val Thr Pro Leu Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Gly Ala Leu Arg Arg Met 290 295 300 Leu Leu Asp Asn Arg Gly Val Gly Lys 305 310

<210> 2317 <211> 906 <212> DNA <213> Felis catus <400> 2317 atggatggaa caaatgacag cactcaggga aatttcatcc ttttggggtt ttctgaccgt 60 ccccatctcg agaggatcct ctttgtggtc atcttgattg catacctcct gactcttatg 120 ggcaacacca ccatcatcct ggtgtcccgg ctggaccccc acctccacac tcctatgtac 180 ttcttcctca cccacctatc tttcctggac ctcagtttca ccaccagctc cattcctcag 240 ctgctctata acctgaatgg ccatgacaag accatcagtt acacaggctg tgccatccag 300 ctcttcctgt ttctgggtct gggtggtgtg gagtgcttgc tcctggctgt catggcatat 360 gaccgattta ttgcagtctg caaacccctg cactacctgg tgatcatgaa tccgcatctc 420 tgcatgggct tagtgtccct tgcttggggc tgtggtgtgg ccaactcttt gattatgtct 480 ccaatgactc tgtggctacc ccgctgtgga tattggaaag tagaccactt cctgtgtgag 540

Page 2565

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atgcctgccc tgattcggat ggcctgtgtc aatacagctg caattgaagg cattgccttt 600 atcctggcag tgggcattgt tctgtcacct ctggtgttta tcctgatatc ctatggctac 660 atcgtgaggg ctgtgttaag tatccagtca tcctcaggga ggcacaaagt cttcaacacc 720 tgtggctccc atctcacagt ggtctccctt ttctatggaa acatcatcta catgtacatg 780 caaccaggaa ccagctcctc caaggaccag ggaaagtttc tcactctttt ctacaacatt 840 gtcacaccgc tcctgaaccc catgatctat accttcagaa acaaagaggt gaaaggggca 900

ctgaga 906 <210> 2318 <211> 302 <212> PRT <213> Felis catus

<400> 2318 Asp Ser Thr Gln Gly Asn Phe Ile Leu Leu Gly Met 1 Asp Gly Thr Asn 5 10 15 Phe Ser Asp Arg Pro His Leu Glu Arg Ile Leu Phe Val Val Ile Leu 20 25 30 Ile Ala Tyr Leu Leu Thr Leu Met Gly Asn Thr Thr Ile Ile Leu Val 35 40 45 Ser Arg Leu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 His Leu Ser Phe Leu Asp Leu Ser Phe Thr Thr Ser Ser Ile Pro Gln 65 70 75 80 Leu Leu Tyr Asn Leu Asn Gly His Asp Lys Thr Ile Ser Tyr Thr Gly 85 90 95 Cys Ala Ile Gln Leu Phe Leu Phe Leu Gly Leu Gly Gly Val Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Ile Ala Val Cys Lys 115 120 125

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Pro Leu His 130 Tyr Leu Val Ile Met Asn Pro His 135 Leu 140 Cys Met Gly Leu Val Ser Leu Ala Trp Gly Cys Gly Val Ala Asn Ser Leu Ile Met Ser 145 150 155 160 Pro Met Thr Leu Trp Leu Pro Arg Cys Gly Tyr Trp Lys Val Asp His 165 170 175 Phe Leu Cys Glu Met Pro Ala Leu Ile Arg Met Ala Cys Val Asn Thr 180 185 190 Ala Ala Ile Glu Gly Ile Ala Phe Ile Leu Ala Val Gly Ile Val Leu 195 200 205 Ser Pro Leu Val Phe Ile Leu Ile Ser Tyr Gly Tyr Ile Val Arg Ala 210 215 220 Val Leu Ser Ile Gln Ser Ser Ser Gly Arg His Lys Val Phe Asn Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Asn Ile Ile 245 250 255 Tyr Met Tyr Met Gln Pro Gly Thr Ser Ser Ser Lys Asp Gln Gly Lys 260 265 270 Phe Leu Thr Leu Phe Tyr Asn Ile Val Thr Pro Leu Leu Asn Pro Met 275 280 285 Ile Tyr Thr Phe Arg Asn Lys Glu Val Lys Gly Ala Leu Arg 290 295 300

<210> 2319 <211> 944 <212> DNA <213> Felis catus <400> 2319

Page 2567

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atggaagatg caaataacac cacagacaca aacttcattc ttctgggact ctttaaccac 60 actcagaccc atctgttcct cttttccatg gtgctcatgg tcttcctttc ctccctgatg 120 ggcaatgccc tcttgattgt gctcatctat gaggaccccc gactgcacat gcccatgtac 180 ttcttgctta gccagctctc cctcatggat gtgatgcttg tctccaccat agtccccaaa 240 atggcagcca actacctaat ggacaccaga tccatctctc ctgctggctg tggggcccag 300 atattcctgt ttctgactct gggagggggc gagtgcttcc tcttagctgc catggcatat 360 gaccgatatg tggccatatg tcaccccctg cgctacccca tcctcatgaa tcagaagctc 420 tgcttgaaca tgaccacagg ctcctggctt ctgggagggg tagatgggct gatgcaagct 480 ggcaccactc tgagcttccc ttactgccat tctcgggaaa tcaaccactt cttctgtgag 540 gcaccctcgc tggttcgcct tgcatgtgca gacactacat tttttgagtt tttcatgtat 600 gtgtgctgca tcctgatgct cttgatccct ctgtctatca ttttggcttc ctacagtctc 660 atcctggctg ctgtgctcaa catgaggtcc actgcagctc gaaagaaagc ctttgccacc 720 tgctcctctc acctggctgt cgtggggctc ttctatggca ctctcatatt cacctacatg 780 cggcccaaat cctaccgtac agtggcccat gacaaggtgg tctctgcttt ttacaccatc 840 tttacacctg tgttgaaccc tcttatatat agtgtgagga ataaagaagt caagggggct 900 ttgaaaaagt ggctggagaa acattttctg ggacatctat agtg 944

<210> 2320 <211> 313 <212> PRT <213> Felis catus

<400> 2320 Asn Thr Thr Asp Thr 10 Asn Phe Ile Leu Leu 15 Gly Met 1 Glu Asp Ala Asn 5 Leu Phe Asn His Thr Gln Thr His Leu Phe Leu Phe Ser Met Val Leu 20 25 30 Met Val Phe Leu Ser Ser Leu Met Gly Asn Ala Leu Leu Ile Val Leu 35 40 45 Ile Tyr Glu Asp Pro Arg Leu His Met Pro Met Tyr Phe Leu Leu Ser Page 2568

069269_0225_SL.TXT

50 55 60 Gln Leu Ser Leu Met Asp Val Met Leu Val Ser Thr Ile Val Pro Lys 65 70 75 80 Met Ala Ala Asn Tyr Leu Met Asp Thr Arg Ser Ile Ser Pro Ala Gly 85 90 95 Cys Gly Ala Gln Ile Phe Leu Phe Leu Thr Leu Gly Gly Gly Glu Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Pro Ile Leu Met Asn Gln Lys Leu Cys Leu Asn Met 130 135 140 Thr Thr Gly Ser Trp Leu Leu Gly Gly Val Asp Gly Leu Met Gln Ala 145 150 155 160 Gly Thr Thr Leu Ser Phe Pro Tyr Cys His Ser Arg Glu Ile Asn His 165 170 175 Phe Phe Cys Glu Ala Pro Ser Leu Val Arg Leu Ala Cys Ala Asp Thr 180 185 190 Thr Phe Phe Glu Phe Phe Met Tyr Val Cys Cys Ile Leu Met Leu Leu 195 200 205 Ile Pro Leu Ser Ile Ile Leu Ala Ser Tyr Ser Leu Ile Leu Ala Ala 210 215 220 Val Leu Asn Met Arg Ser Thr Ala Ala Arg Lys Lys Ala Phe Ala Thr 225 230 235 240 Cys Ser Ser His Leu Ala Val Val Gly Leu Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Thr Tyr Met Arg Pro Lys Ser Tyr Arg Thr Val Ala His Asp Lys

Page 2569

260

069269_0225_SL.TXT 265 270

Val Val Ser 275 Ala Phe Tyr Thr Ile Phe Thr Pro Val Leu Asn Pro Leu 280 285 Ile Tyr Ser Val Arg Asn Lys Glu Val Lys Gly Ala Leu Lys Lys Trp 290 295 300 Leu Glu Lys His Phe Leu Gly His Leu 305 310

<210> 2321 <211> 939 <212> DNA <213> Felis catus <400> 2321

atgatgggac atgaaaatca cactttcacc agtgatttta ttcttttggg actcttctct 60 tcttctcaat caagtctagt tttcttttcc tttatattca tcatttttat tatgactgta 120 acagaaaaca cagtcataat cctccttatc ctcagggact caagactcca cactccgatg 180 tatttcctgc tgagccatct ctcttttatg gacatcttgc atatttccaa cattgttccc 240 aaaatggtca ctgactttct gtcaggcagc agaactattt catttgtagg ttgtggcttc 300 caggtatttc tatccctcac tctcctgggt ggtgagtgcc ttctcctggc agcaatgtct 360 tatgatcgct atgtagccat ctgtcatcca ttgcactatc ccattcttat gaatgactat 420 gtctgcattg tcatggctag agggtcctgg cttattggga ctgtcaactc catagtccac 480 acagcttatg cactccactt tcccttctgt gcctcaagag ctattgatca ctttttctgt 540 gaagtccctg ccatgttgaa gttgtcctgt gtggacacaa cactgtatga acgaagaatt 600 tatgtaagtg gcttaatttt tctgcttgtc cctttctccc taatcattgc ttcttatgtc 660 caaattctca ttactgtatt tcaaatgaaa tcatcagaag cacggaaaaa gtcattttct 720 acctgttcct tccacatgat ggtggtcaca atgtattatg ggccatttat tttcacatac 780 atgagaccca aatcatacca cactccaggc caggacaagt ctttggcaat attctatacc 840 atcctcacac ctacattcaa ccctataatc tacagcttta ggaataaaga tgtccttgag 900 gcaatgaaaa atatgctcaa aagtaacttt ctccattaa 939

Page 2570

069269_0225_SL.TXT <210> 2322 <211> 312 <212> PRT <213> Felis catus

<400> 2322 Met 1 Met Gly His Glu 5 Asn His Thr Phe Thr Ser Asp Phe Ile Leu Leu 10 15 Gly Leu Phe Ser Ser Ser Gln Ser Ser Leu Val Phe Phe Ser Phe Ile 20 25 30 Phe Ile Ile Phe Ile Met Thr Val Thr Glu Asn Thr Val Ile Ile Leu 35 40 45 Leu Ile Leu Arg Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu 50 55 60 Ser His Leu Ser Phe Met Asp Ile Leu His Ile Ser Asn Ile Val Pro 65 70 75 80 Lys Met Val Thr Asp Phe Leu Ser Gly Ser Arg Thr Ile Ser Phe Val 85 90 95 Gly Cys Gly Phe Gln Val Phe Leu Ser Leu Thr Leu Leu Gly Gly Glu 100 105 110 Cys Leu Leu Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 His Pro Leu His Tyr Pro Ile Leu Met Asn Asp Tyr Val Cys Ile Val 130 135 140 Met Ala Arg Gly Ser Trp Leu Ile Gly Thr Val Asn Ser Ile Val His 145 150 155 160 Thr Ala Tyr Ala Leu His Phe Pro Phe Cys Ala Ser Arg Ala Ile Asp 165 170 175

Page 2571

069269_0225_SL.TXT

His Phe Phe Cys Glu Val Pro Ala Met Leu Lys Leu Ser Cys Val Asp 190 180 185 Thr Thr Leu Tyr Glu Arg Arg Ile Tyr Val Ser Gly Leu Ile Phe Leu 195 200 205 Leu Val Pro Phe Ser Leu Ile Ile Ala Ser Tyr Val Gln Ile Leu Ile 210 215 220 Thr Val Phe Gln Met Lys Ser Ser Glu Ala Arg Lys Lys Ser Phe Ser 225 230 235 240 Thr Cys Ser Phe His Met Met Val Val Thr Met Tyr Tyr Gly Pro Phe 245 250 255 Ile Phe Thr Tyr Met Arg Pro Lys Ser Tyr His Thr Pro Gly Gln Asp 260 265 270 Lys Ser Leu Ala Ile Phe Tyr Thr Ile Leu Thr Pro Thr Phe Asn Pro 275 280 285 Ile Ile Tyr Ser Phe Arg Asn Lys Asp Val Leu Glu Ala Met Lys Asn 290 295 300 Met Leu Lys Ser Asn Phe Leu His

305 310 <210> 2323 <211> 940 <212> DNA

<213> Felis ; catus <400> 2323 atggaaaata ataaccaaac atctactgat tttttcttat tgggattatt cccaccatca gaaattggcc tgttttcctt cattttcatt gttctcattt tcttaatggc tctttttggc aacatgtcca tgatcatcgt catcctcctg gacactcatc tccacacacc catgtatttt ctacttagtc agctctccct catggacctg aactacatct ccaccattgt ccccaagatg gcgtccaatt atctctttgg aaataagtcg atttctttca ttgggtgtgg agttcagagt

120

180

240

300

Page 2572

069269_0225_SL.TXT

ttcttcttca ttacattagc tggtgcagaa ggattactgt tggcctgtat ggcttatgat 360 cgttatgtgg ccatttgctt tcctcttcac tatgtcattc atatgagaaa aagagtactt 420 gtgttgatga ttacaggatc ttggataatg agctcgatca actcctgtgc ccacaatgta 480 tatgccctcc atatccctta ttgtcgatcc agaaccatca atcatttctt ctgtgatctc 540 ccggccatgt tgacactggc ctgcatggac acctgggtct atgaatacac ggtgtttgtg 600 agcaccacac tcttccttgt gttacctttc attggcattg catgttccta tggccgagtt 660 ctcctcacca tctgccgcat gcactcaaca gaagggagga agaaggccta ttccacctgt 720 agcacacacc tcactgtggt aactttctac tatgcaccct ttgcttacac ttacctacgc 780 ccaagatcac tgagaactcc aacagaggac aaaattctgg ccgtcttcta cacgatcctg 840 accccaatgc tcaaccccat catttacagc ttgagaaaca aggaggtgat gggagccctg 900 agaagagtga ttcagaggat ctgctgctct gtataagtgt 940

<210> 2324 <211> 311 <212> PRT <213> Felis catus <400> 2324

Met Glu Asn Asn Asn Gln Thr Ser Thr Asp Phe Phe Leu Leu Gly Leu 1 5 10 15 Phe Pro Pro Ser Glu Ile Gly Leu Phe Ser Phe Ile Phe Ile Val Leu 20 25 30 Ile Phe Leu Met Ala Leu Phe Gly Asn Met Ser Met Ile Ile Val Ile 35 40 45 Leu Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 50 55 60 Leu Ser Leu Met Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met 65 70 75 80 Ala Ser Asn Tyr Leu Phe Gly Asn Lys Ser Ile Ser Phe Ile Gly Cys 85 90 95

Page 2573

069269_0225_SL.TXT

Gly Val Gln Ser 100 Phe Phe Phe Ile Thr Leu Ala Gly Ala Glu Gly Leu 105 110 Leu Leu Ala Cys Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro 115 120 125 Leu His Tyr Val Ile His Met Arg Lys Arg Val Leu Val Leu Met Ile 130 135 140 Thr Gly Ser Trp Ile Met Ser Ser Ile Asn Ser Cys Ala His Asn Val 145 150 155 160 Tyr Ala Leu His Ile Pro Tyr Cys Arg Ser Arg Thr Ile Asn His Phe 165 170 175 Phe Cys Asp Leu Pro Ala Met Leu Thr Leu Ala Cys Met Asp Thr Trp 180 185 190 Val Tyr Glu Tyr Thr Val Phe Val Ser Thr Thr Leu Phe Leu Val Leu 195 200 205 Pro Phe Ile Gly Ile Ala Cys Ser Tyr Gly Arg Val Leu Leu Thr Ile 210 215 220 Cys Arg Met His Ser Thr Glu Gly Arg Lys Lys Ala Tyr Ser Thr Cys 225 230 235 240 Ser Thr His Leu Thr Val Val Thr Phe Tyr Tyr Ala Pro Phe Ala Tyr 245 250 255 Thr Tyr Leu Arg Pro Arg Ser Leu Arg Thr Pro Thr Glu Asp Lys Ile 260 265 270 Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Arg Arg Val Ile 290 295 300

Page 2574

069269_0225_SL.TXT

Gln Arg Ile Cys Cys Ser Val 305 310 <210> 2325 <211> 939 <212> DNA <213> Felis catus <400> 2325

atggaaaatt atactcaaaa atcaactgat ttcattttat tggggttgtt tccaccatca 60 agaataggcc tgctcctttt tattctcatt gtcctcattt ttctaatggc tctgtttggc 120 aacctgtcca tgattctact catcttccta gacacccatc tacacacacc catgtatttc 180 ttacttagtc agctctccct cattgaccta aattacatct ccactattgt tcccaagatg 240 gcttccaatt ttgtgtttgg aaacaagtct atctccttca ttgggtgtgg ttttcagagc 300 ttctttttct tgactttagg aggggcagaa gcattgctct tgacatctat ggcttatgat 360 cgttatgtgg ctatttgctt tcctcttcac tatcccattc gtatgagcaa aaaagtgtgt 420 gtgttgatga taacaggatc ttggataatg ggctcaatca actcctgtgc ccacactgta 480 tatgccctcc atatccctta ttgtcgatcc aggtccatca accatttctt ctgtgatgtc 540 ccagccatgt tgactctggc ttgcatggac acttgggtct atgagtacac agtgtttgtg 600 agtaccaccc tctttcttgt gtttcctttc attggcattg catgttccta tggccgagtt 660 ctccttgcca tctgccgcat gcactcaaca gaagggagga agagggccta ttcgacctgc 720 agcacacacc tcacagtggt aactttatac tatgtacctt ttgcttacac ttacctacgc 780 ccaagatcgc tgagatctcc agcagaggac aaggttctgg ctgtcttcta caccattctg 840 accccaatgc tcaaccctat catttacagc ctgcgaaaca aggaggtgat gggagccctg 900 agaagaatga ttcagagaat ctgctttttg aaaatgtag 939

<210> 2326 <211> 312 <212> PRT <213> Felis catus <400> 2326

Met Glu Asn Tyr Thr Gln Lys Ser Thr Asp Phe Ile Leu Leu Gly Leu 1 5 10 15

Page 2575

069269_0225_SL.TXT

Phe Pro Pro Ser 20 Arg Ile Gly Leu Leu Leu Phe Ile Leu Ile Val Leu 25 30 Ile Phe Leu Met Ala Leu Phe Gly Asn Leu Ser Met Ile Leu Leu Ile 35 40 45 Phe Leu Asp Thr His Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln 50 55 60 Leu Ser Leu Ile Asp Leu Asn Tyr Ile Ser Thr Ile Val Pro Lys Met 65 70 75 80 Ala Ser Asn Phe Val Phe Gly Asn Lys Ser Ile Ser Phe Ile Gly Cys 85 90 95 Gly Phe Gln Ser Phe Phe Phe Leu Thr Leu Gly Gly Ala Glu Ala Leu 100 105 110 Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro 115 120 125 Leu His Tyr Pro Ile Arg Met Ser Lys Lys Val Cys Val Leu Met Ile 130 135 140 Thr Gly Ser Trp Ile Met Gly Ser Ile Asn Ser Cys Ala His Thr Val 145 150 155 160 Tyr Ala Leu His Ile Pro Tyr Cys Arg Ser Arg Ser Ile Asn His Phe 165 170 175 Phe Cys Asp Val Pro Ala Met Leu Thr Leu Ala Cys Met Asp Thr Trp 180 185 190 Val Tyr Glu Tyr Thr Val Phe Val Ser Thr Thr Leu Phe Leu Val Phe 195 200 205 Pro Phe Ile Gly Ile Ala Cys Ser Tyr Gly Arg Val Leu Leu Ala Ile 210 215 220

Page 2576

069269_0225_SL.TXT

Cys Arg 225 Met His Ser Thr Glu Gly Arg Lys Arg Ala Tyr Ser Thr Cys 230 235 240 Ser Thr His Leu Thr Val Val Thr Leu Tyr Tyr Val Pro Phe Ala Tyr 245 250 255 Thr Tyr Leu Arg Pro Arg Ser Leu Arg Ser Pro Ala Glu Asp Lys Val 260 265 270 Leu Ala Val Phe Tyr Thr Ile Leu Thr Pro Met Leu Asn Pro Ile Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Met Gly Ala Leu Arg Arg Met Ile 290 295 300 Gln Arg Ile Cys Phe Leu Lys Met

305 310 <210> 2327 <211> 924 <212> DNA <213> Felis catus

<400> 2327 atggaaaata acagccaaac attaacaggc ttccttttat tggggttttt cccccatcaa 60 gaattgggtt gtttcttttc attctcatta ttgtcatttt cctaatggct ttttttggca 120 acatgtccat gattctcctc atcctcctgg acacccatct ccacacatcc atgtattttc 180 tacttagtca cctctccctc atggacttga acttcatctc caccatcatt ccccagatgg 240 catccaatta tgtctttgga aacaagtcta tctccttcat tgggtgtggg atacagagct 300 tctttttgac tttagcagat gcagatgggt tactattggc ctccatgtcc catgatcgct 360 atgtgactat ttgctttcct cttcattatc ccattcgtat gagcaaaaaa gtgtgtgtgt 420 tgataataac aggatcttgg ataatgggct caatcaactc ctgtgcccac actgtatatg 480 ccctccatat cccttatggt tgatccgggt tcatcaacca tttcttctgt gatgtcctag 540 ccatgttgac tctggcttgc atggacacct atgatctatg agtacacagt gtttgtgagc 600

Page 2577

069269_0225_SL.TXT

accacactct tgattgcatt tctcttcatc ggcattgcat gttcctgtgg ccgagttctc 660 catgctatct gccacatgca ctcaacagaa ggaaggaaga agccctattc aacctgcagc 720 acacacctca ttgtggtgac tttctactct gcaccctttg cttacattta cctatgccca 780 agatcgctga gatctcccac agaagccaag gttctggttg tcttctacat tattctgacc 840 ccaatgctcg accccatcat ttatatcctg agaaacaagg aggtgatggg agccttgaga 900 agagtgattc agaggatctg ctct 924

<210> 2328 <211> 118 <212> PRT <213> Felis catus <400> 2328

Met Ile Tyr Glu Tyr Thr Val Phe Val Ser Thr Thr Leu Leu Ile Ala 1 5 10 15 Phe Leu Phe Ile Gly Ile Ala Cys Ser Cys Gly Arg Val Leu His Ala 20 25 30 Ile Cys His Met His Ser Thr Glu Gly Arg Lys Lys Pro Tyr Ser Thr 35 40 45 Cys Ser Thr His Leu Ile Val Val Thr Phe Tyr Ser Ala Pro Phe Ala 50 55 60 Tyr Ile Tyr Leu Cys Pro Arg Ser Leu Arg Ser Pro Thr Glu Ala Lys 65 70 75 80 Val Leu Val Val Phe Tyr Ile Ile Leu Thr Pro Met Leu Asp Pro Ile 85 90 95 Ile Tyr Ile Leu Arg Asn Lys Glu Val Met Gly Ala Leu Arg Arg Val 100 105 110 Ile Gln Arg Ile Cys Ser

<210> 2329

115

Page 2578

069269_0225_SL.TXT <211> 914 <212> DNA <213> Felis catus <400> 2329

atggccaatg tcactttagt gacaggattt cttcttgtgg agttttctga catccaagag 60 cttcagatat tatatggtgt gctcttccta ctgatttatc tggctgtcct gatgagtaac 120 cttctcatca tcactctcat taccctagac cagcatctac agacaccgat gtactttttc 180 ctgaagaatt tgtcattcct ggatgtcttc cttgtgtctg tcccaatccc caaattgatt 240 gtcaacagcc taacatacag caattccatc tccattttag ggtgtgcctt ccagctactt 300 ttcatgactt ccttctcagc aagtgagata tttgtcctta ctgccatgtc ctatgaccgc 360 tatgtagcca tatgctgtcc tctgcagtac gaagtcatca tgaacgctgg tgcctgtaca 420 ctgatggcag gtgtttcctg ggccattgga ggactctttg gaactgtgta tactgctggc 480 acatttttca tgccattctg tggctccaat gtgattccac agtttttctg tgatgtttcc 540 tcattgctaa gtatctcctg ttctgaaaca ctcctagtgg tgtatacaag tattgggata 600 ggtatgtgtt taggcatatc ttgtttcatc tgtattgtga tctcctatgc ttacattttc 660 tccactgtgc tgaagattcc taccacaaaa ggtcagtcaa aagctttctc cacatgcttt 720 ccccatcttg ttgtttttac tctttttatt ataactgcct gttttgttta tctgaaagca 780 acctcaaata cacccctagt tattgacagg ttgctttctg tggtttacac cgtgatacct 840 ccaatactca accctgtaat ctacagcctg aggaacaagg acatgaaatg ggctcttacg 900 agattgctgc agaa 914

<210> 2330 <211> 305 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (305)..(305) <223> Any amino acid <400> 2330

Met Ala Asn Val Thr Leu Val Thr Gly Phe Leu Leu Val Glu Phe Ser 1 5 10 15

Page 2579

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Asp Ile Gln Glu 20 Leu Gln Ile Leu Tyr Gly Val Leu Phe Leu Leu Ile 25 30 Tyr Leu Ala Val Leu Met Ser Asn Leu Leu Ile Ile Thr Leu Ile Thr 35 40 45 Leu Asp Gln His Leu Gln Thr Pro Met Tyr Phe Phe Leu Lys Asn Leu 50 55 60 Ser Phe Leu Asp Val Phe Leu Val Ser Val Pro Ile Pro Lys Leu Ile 65 70 75 80 Val Asn Ser Leu Thr Tyr Ser Asn Ser Ile Ser Ile Leu Gly Cys Ala 85 90 95 Phe Gln Leu Leu Phe Met Thr Ser Phe Ser Ala Ser Glu Ile Phe Val 100 105 110 Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Cys Pro Leu 115 120 125 Gln Tyr Glu Val Ile Met Asn Ala Gly Ala Cys Thr Leu Met Ala Gly 130 135 140 Val Ser Trp Ala Ile Gly Gly Leu Phe Gly Thr Val Tyr Thr Ala Gly 145 150 155 160 Thr Phe Phe Met Pro Phe Cys Gly Ser Asn Val Ile Pro Gln Phe Phe 165 170 175 Cys Asp Val Ser Ser Leu Leu Ser Ile Ser Cys Ser Glu Thr Leu Leu 180 185 190 Val Val Tyr Thr Ser Ile Gly Ile Gly Met Cys Leu Gly Ile Ser Cys 195 200 205 Phe Ile Cys Ile Val Ile Ser Tyr Ala Tyr Ile Phe Ser Thr Val Leu 210 215 220

Page 2580

069269_0225_SL.TXT

Lys Ile 225 Pro Thr Thr Lys Gly 230 Gln Ser Lys Ala Phe Ser Thr Cys Phe 235 240 Pro His Leu Val Val Phe Thr Leu Phe Ile Ile Thr Ala Cys Phe Val 245 250 255 Tyr Leu Lys Ala Thr Ser Asn Thr Pro Leu Val Ile Asp Arg Leu Leu 260 265 270 Ser Val Val Tyr Thr Val Ile Pro Pro Ile Leu Asn Pro Val Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Met Lys Trp Ala Leu Thr Arg Leu Leu Gln 290 295 300

Xaa

305 <210> 2331 <211> 927 <212> DNA <213> Felis catus <400> 2331

atgggcacag acaatgcaac tcactcccag gatttcctct tgctgggctt tcctgggtcc 60 cagggccttc agctatctct ccttatgctt tttctggtga tgtacatcct cacagtgagt 120 ggtaacatgg ctatcttgat gttggtgagt acctcccacc agctacatac ccctatgtac 180 ttctttctga gcaacctctc tttcttggag atttggtata ccacagctgc agtccccaaa 240 gtcctggcca tccttctggg gagaagccaa accatatcat ttactggatg tcttttgcag 300 atgtactttg ttttttcatt gggctgcaca gagtactttc tcctggcagc catggcttat 360 gaccgctatt tggccatctg ctatcctcta cactatgggg ccattatgag cagtctgctc 420 tcagcactgc tagccctggg atcctgggtg tgcggtttcc tagccattgc agtgcccaca 480 gccctcatta gcaccctgcc gttctgtggt ccccacacta tcaaccactt cttctgtgac 540 attgcaccct ggattaccct ggcttgcacc agcacgcagg cagtggaact cgtggccttt 600

Page 2581

069269_0225_SL.TXT gtgattgctt ttgtggtcat cctgagctcg tgcctcatca ctctggtctc ttatgtgtat 660 atcatcagca ccattctcag gatcccttca gccagtggca ggagtaaagc cttctccaca 720 tgctctttgc atatcactgt ggtgctagtc tggtacgggt ccacgatctt tcttcatgtc 780 cgcatctcca tcaaagaggc cttggatctg accaaagtcg tgcatgtcct gaacaccatt 840 gtgactccag ttctaaaccc cttcatctac actctccgta acaaggaagt aagagaaact 900 ctgctgaaga aatggaaggg aaaataa 927 <210> 2332 <211> 308 <212> PRT <213> Felis catus

<400> 2332 Ala Thr His Ser Gln Asp Phe Leu Leu Leu Gly Met 1 Gly Thr Asp Asn 5 10 15 Phe Pro Gly Ser Gln Gly Leu Gln Leu Ser Leu Leu Met Leu Phe Leu 20 25 30 Val Met Tyr Ile Leu Thr Val Ser Gly Asn Met Ala Ile Leu Met Leu 35 40 45 Val Ser Thr Ser His Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Ala Val Pro Lys 65 70 75 80 Val Leu Ala Ile Leu Leu Gly Arg Ser Gln Thr Ile Ser Phe Thr Gly 85 90 95 Cys Leu Leu Gln Met Tyr Phe Val Phe Ser Leu Gly Cys Thr Glu Tyr 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Tyr 115 120 125

Pro Leu His

Tyr Gly Ala Ile Met

Ser Ser Leu Leu

Ser Ala Leu Leu

Page 2582

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130 135 140 Ala Leu Gly Ser Trp Val Cys Gly Phe Leu Ala Ile Ala Val Pro Thr 145 150 155 160 Ala Leu Ile Ser Thr Leu Pro Phe Cys Gly Pro His Thr Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Ala Pro Trp Ile Thr Leu Ala Cys Thr Ser Thr 180 185 190 Gln Ala Val Glu Leu Val Ala Phe Val Ile Ala Phe Val Val Ile Leu 195 200 205 Ser Ser Cys Leu Ile Thr Leu Val Ser Tyr Val Tyr Ile Ile Ser Thr 210 215 220 Ile Leu Arg Ile Pro Ser Ala Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Leu His Ile Thr Val Val Leu Val Trp Tyr Gly Ser Thr Ile 245 250 255 Phe Leu His Val Arg Ile Ser Ile Lys Glu Ala Leu Asp Leu Thr Lys 260 265 270 Val Val His Val Leu Asn Thr Ile Val Thr Pro Val Leu Asn Pro Phe 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Glu Val Arg Glu Thr Leu Leu Lys Lys 290 295 300 Trp Lys Gly Lys

305 <210> 2333 <211> 924 <212> DNA <213> Felis catus

Page 2583

069269_0225_SL.TXT <400> 2333 atgaataaca gcattgtaac tgagtttatg attctgggac ttacccaaaa tcctgaactg 60 cagggagttc tcttcattgt ctttctctgc atctaccttg tggccttttt tggcaatggc 120 ctaattatca ttgttataat ctataatacc accttgcata cgcccatgta tgtgttcctc 180 ctggcactag ctattgtgga tatcatctgt acaacaagca ttataccaaa gatgctgggg 240 accatgctaa catcaggaaa gagtatttca tatggaagct gcatgtccca gctcttcttc 300 ttcacgtggt cattgggggc tgagatggta ctcttcacca caatggccta tgaccgttat 360 gtggccatct gttttcctct tcgctacagc actattatga accaccatat gtgtgtggcc 420 ttgcttagca ttgccatggt tattgcagta accaattcct gggtacacac aggtctcatc 480 ctgaacctga ctttctgtgg gccaaataac attgaccact tcttctgtga gataccccca 540 ctgctctctt tgtcctgcag tcctgtgaga attaatgagg tgatggtata tgttgctgat 600 atttccctgg ccataggtga cttcagcctc acctgcctgt cttatggttt tatcattgct 660 gccattctcc gcatccgcac agcagaaggc aagaggaagg ctttttcaac atgttcatcc 720 cacctcatag ttgtgtccct ttactactgc cctgtaatct acacatatat ccgccctgct 780 tccagctact catttgaaag ggacaaggtg atagctgcac tatatactct tgtgacccca 840 acattaaacc caattgtgta tagtttacga aacaaggaga tgcagacagg gattcagaaa 900 gtctttgcat ttttgaaaca ttag 924 <210> 2334 <211> 307 <212> PRT <213> Felis catus <400> 2334

Met 1 Asn Asn Ser Ile Val Thr Glu Phe Met Ile Leu Gly Leu Thr Gln 5 10 15 Asn Pro Glu Leu Gln Gly Val Leu Phe Ile Val Phe Leu Cys Ile Tyr 20 25 30 Leu Val Ala Phe Phe Gly Asn Gly Leu Ile Ile Ile Val Ile Ile Tyr 35 40 45

Page 2584

Asn Thr 50 Thr Leu His Thr Pro 55 069269_0225_SL.TXT Met Tyr Val Phe Leu Leu 60 Ala Leu Ala Ile Val Asp Ile Ile Cys Thr Thr Ser Ile Ile Pro Lys Met Leu Gly 65 70 75 80 Thr Met Leu Thr Ser Gly Lys Ser Ile Ser Tyr Gly Ser Cys Met Ser 85 90 95 Gln Leu Phe Phe Phe Thr Trp Ser Leu Gly Ala Glu Met Val Leu Phe 100 105 110 Thr Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe Pro Leu Arg 115 120 125 Tyr Ser Thr Ile Met Asn His His Met Cys Val Ala Leu Leu Ser Ile 130 135 140 Ala Met Val Ile Ala Val Thr Asn Ser Trp Val His Thr Gly Leu Ile 145 150 155 160 Leu Asn Leu Thr Phe Cys Gly Pro Asn Asn Ile Asp His Phe Phe Cys 165 170 175 Glu Ile Pro Pro Leu Leu Ser Leu Ser Cys Ser Pro Val Arg Ile Asn 180 185 190 Glu Val Met Val Tyr Val Ala Asp Ile Ser Leu Ala Ile Gly Asp Phe 195 200 205 Ser Leu Thr Cys Leu Ser Tyr Gly Phe Ile Ile Ala Ala Ile Leu Arg 210 215 220 Ile Arg Thr Ala Glu Gly Lys Arg Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Leu Ile Val Val Ser Leu Tyr Tyr Cys Pro Val Ile Tyr Thr Tyr 245 250 255

Page 2585

069269_0225_SL.TXT Ile Arg Pro Ala Ser Ser Tyr Ser Phe Glu Arg Asp Lys Val Ile Ala 260 265 270

Ala Leu Tyr Thr Leu Val Thr Pro Thr Leu Asn Pro Ile Val Tyr Ser 275 280 285

Leu Arg Asn Lys Glu Met Gln Thr Gly Ile Gln Lys Val Phe Ala Phe 290 295 300

Leu Lys His 305 <210> 2335 <211> 873 <212> DNA <213> Felis catus <400> 2335

agtatagata ataggattta aggttggggt caccatggtg tagaagaggg agataaactt 60 gccttggtcc tgagcataac tgttacctgg ttgtaggtac atgtagatta tggtgccata 120 gaaaatgatc accactgtaa ggtgggagga acaggtgctg aaggctttgt gtcttgcctc 180 tgctgatttt atcctcagca cagcttgact tatgaagcca taggagataa gaatgagtgc 240 tgggggaatt aggagaaaca ggatactaac cacaaaaagc accaactcat tgacagtggt 300 gtccacacaa gccaatttga ggagagctgg tacttcacaa ataaaatgat tgagtctatg 360 gttgccacag agaggcaatt gcaaggtaaa agtagcatgg atcagggaat tgctcaaacc 420 actgagccag gagagggatg ccagctgttg gcatagctgt ggattcatga tagccacata 480 gtggaggggt ttgcagacag caatgtagcg atccaaagcc attacagcca agaggataca 540 ctcagtggaa cccagcgcta gagaaatata gagttgtacc acacaaccac cataggtgat 600 agtcttctct ggacctctca ggttgactaa agtctgaggt gcaaggctgg tagtgaagca 660 gaggtccagt agggagaggt tgctgaggaa gaagtacatg ggggtgtgga ggagaggatc 720 cacgtatgat ataatgatga tggcaaagtt ccccacaagc gtcaggatat agaaaaaaag 780 gactaataca aagagtgcag actccaggcg agggttgtct gagaagccta gaaggatgaa 840 actcatcagg gaactttcat tggccctttc cat 873

Page 2586

069269_0225_SL.TXT <210> 2336 <211> 291 <212> PRT <213> Felis catus

<400> 2336 Met 1 Glu Arg Ala Asn Glu 5 Ser Ser Leu Met 10 Ser Phe Ile Leu Leu 15 Gly Phe Ser Asp Asn Pro Arg Leu Glu Ser Ala Leu Phe Val Leu Val Leu 20 25 30 Phe Phe Tyr Ile Leu Thr Leu Val Gly Asn Phe Ala Ile Ile Ile Ile 35 40 45 Ser Tyr Val Asp Pro Leu Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Leu Leu Asp Leu Cys Phe Thr Thr Ser Leu Ala Pro Gln 65 70 75 80 Thr Leu Val Asn Leu Arg Gly Pro Glu Lys Thr Ile Thr Tyr Gly Gly 85 90 95 Cys Val Val Gln Leu Tyr Ile Ser Leu Ala Leu Gly Ser Thr Glu Cys 100 105 110 Ile Leu Leu Ala Val Met Ala Leu Asp Arg Tyr Ile Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Val Ala Ile Met Asn Pro Gln Leu Cys Gln Gln Leu 130 135 140 Ala Ser Leu Ser Trp Leu Ser Gly Leu Ser Asn Ser Leu Ile His Ala 145 150 155 160 Thr Phe Thr Leu Gln Leu Pro Leu Cys Gly Asn His Arg Leu Asn His 165 170 175 Phe Ile Cys Glu Val Pro Ala Leu Leu Lys Leu Ala Cys Val Asp Thr

Page 2587

180

069269_0225_SL.TXT 185 190

Thr Val Asn Glu Leu Val 195 Leu Phe Val Val Ser Ile Leu Phe Leu Leu 200 205 Ile Pro Pro Ala Leu Ile Leu Ile Ser Tyr Gly Phe Ile Ser Gln Ala 210 215 220 Val Leu Arg Ile Lys Ser Ala Glu Ala Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Ile 245 250 255 Tyr Met Tyr Leu Gln Pro Gly Asn Ser Tyr Ala Gln Asp Gln Gly Lys 260 265 270 Phe Ile Ser Leu Phe Tyr Thr Met Val Thr Pro Thr Leu Asn Pro Ile 275 280 285

Ile Tyr Thr 290 <210> 2337 <211> 962 <212> DNA <213> Felis catus <400> 2337

tgatgatggg aatagccaat gcaagttctc cagaagtctt tgtactcctg ggcttctctg 60 cacgaccctc actggaacct atcctcttca tcattgcctt agggttttat gtggtgtctg 120 tcttggacaa tggcatcatc attctggttt cctgcatgga tgtgcacctc cacactccta 180 tgtatttctt ccttgccaat ctctccttcc tggacattag ctttaccaca agcattgtcc 240 cacaactcct ggtcaacctc tggggaccac agaaaaccat aagctctgta gggtgtatgg 300 tccagttcta catctctcac tggctggggg ccaccgaatg tgtccttctg gcagtcatgt 360 cctatgatcg ctatgccgcc atttgtaggc cactacatta tactgtcatc atgcatccac 420 agctttgtct cagcttggcc tttgcttcct ggcttggggg tctgactaca agcatagtgg 480

Page 2588

069269_0225_SL.TXT

gctccacact cactatgctt ctgccactgt gtggaaacaa tcgcattgac cacttcttct 540 gtgagatgcc cctcattatg caactggctt gtgtggatac cagcctcaat gaggtggaga 600 tgtatgtggc cagctttatc tttgttgtct tgcctctggg tctcatcctg gtttcatatg 660 gccacattgc ctgggctgta atgaagatca ggtcagcaga aggacggaga aaggccttca 720 acacctgctc ttcccatgtg gcagttgtga ctctatttta tgggagcatc atctttatgt 780 atctccagcc agccaagagt aactctcatg aacagggtaa attcatagcc ctcttctata 840 ctgttgtcac cccgatgctg aaccccctga tttacacact caggaacaaa gatgtgaaga 900 aggctctcag gcacattgca tcagagaatt gctgtggctt tgcaggatca ttgggacata 960

tt 962 <210> 2338 <211> 320 <212> PRT <213> Felis catus

<400> 2338 Asn Ala Ser Ser Pro Glu Val Phe Val Leu Leu Met Met 1 Gly Ile Ala 5 10 15 Gly Phe Ser Ala Arg Pro Ser Leu Glu Pro Ile Leu Phe Ile Ile Ala 20 25 30 Leu Gly Phe Tyr Val Val Ser Val Leu Asp Asn Gly Ile Ile Ile Leu 35 40 45 Val Ser Cys Met Asp Val His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ala Asn Leu Ser Phe Leu Asp Ile Ser Phe Thr Thr Ser Ile Val Pro 65 70 75 80 Gln Leu Leu Val Asn Leu Trp Gly Pro Gln Lys Thr Ile Ser Ser Val 85 90 95 Gly Cys Met Val Gln Phe Tyr Ile Ser His Trp Leu Gly Ala Thr Glu 100 105 110

Page 2589

069269_0225_SL.TXT

Cys Val Leu 115 Leu Ala Val Met Ser Tyr Asp Arg Tyr Ala Ala Ile Cys 120 125 Arg Pro Leu His Tyr Thr Val Ile Met His Pro Gln Leu Cys Leu Ser 130 135 140 Leu Ala Phe Ala Ser Trp Leu Gly Gly Leu Thr Thr Ser Ile Val Gly 145 150 155 160 Ser Thr Leu Thr Met Leu Leu Pro Leu Cys Gly Asn Asn Arg Ile Asp 165 170 175 His Phe Phe Cys Glu Met Pro Leu Ile Met Gln Leu Ala Cys Val Asp 180 185 190 Thr Ser Leu Asn Glu Val Glu Met Tyr Val Ala Ser Phe Ile Phe Val 195 200 205 Val Leu Pro Leu Gly Leu Ile Leu Val Ser Tyr Gly His Ile Ala Trp 210 215 220 Ala Val Met Lys Ile Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe Asn 225 230 235 240 Thr Cys Ser Ser His Val Ala Val Val Thr Leu Phe Tyr Gly Ser Ile 245 250 255 Ile Phe Met Tyr Leu Gln Pro Ala Lys Ser Asn Ser His Glu Gln Gly 260 265 270 Lys Phe Ile Ala Leu Phe Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Lys Ala Leu Arg His 290 295 300 Ile Ala Ser Glu Asn Cys Cys Gly Phe Ala Gly Ser Leu Gly His Ile 305 310 315 320

Page 2590

069269_0225_SL.TXT <210> 2339 <211> 945 <212> DNA <213> Felis catus <400> 2339

ttaggtttcc ctgtcctcct tctctccctt caggagcttt ctcattgctc cctttacatc 60 tttgttcctc agagtataga taagggggtt gacactggga gtgacgatgg tgtagaagag 120 ggtgaggaac ttgccttggt cttgggagta gctattggct ggctgcaggt acatgtagat 180 gatggttcca tagaaaagag agaccaccgt taggtgagaa gagcaggtgt tgaaagcttt 240 cttgcaccct gctgctgatt tgatcctaag cacagtggca gaaatcatgc cataggagat 300 gaggatcagg gagaggggca ccaggagaag ggcaacaccc aggacaaagg caaatgcttc 360 caccaacatg gtgtcttcac aagacatggc aataagagca ggcatctcac acagaaagtg 420 gtccactttg tggcgcccac atcgggagag ttgcattgtc tggggacaca tgacaaagga 480 atttagaaag ccacagaacc aggacacaat caccaattgc aggcagagat gtgggtgcat 540 gaccacagtg tagtgcaggg gccggcagac ggccacgtag cggtcataag acatgacagc 600 caggagaaca cactcggttg agcccaacac catgtagata tagagctggg ccacacagcc 660 ttggtaggtg atggtcttct ctggacccca aaggttccac agcagctggg gagcaatgct 720 ggttgtaaag cagaggtcca agaaagaaag gttcccaaga aagaagtaca tgggagtgtg 780 gagcctggtg tccatgactg ataagaaaat gatggcacta ttgcccacaa gggccaggat 840 gtagaagacc aagacaaaag caaagagaat tacctccagt tgaggtcgat cagaaaagcc 900 caccaagatg aatgcttgtt ggtaactgtc attgtctctt cccat 945

<210> 2340 <211> 314 <212> PRT <213> Felis catus <400> 2340

Met Gly Arg Asp Asn Asp Ser Tyr Gln Gln Ala Phe Ile Leu Val Gly

1 5 10 15 Phe Ser Asp Arg Pro Gln Leu Glu Val Ile Leu Phe Ala Phe Val Leu

Page 2591

069269_0225_SL.TXT 25 30

Val Phe Tyr Ile Leu Ala Leu Val Gly Asn Ser Ala Ile Ile Phe Leu 35 40 45 Ser Val Met Asp Thr Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Ile Ala Pro Gln 65 70 75 80 Leu Leu Trp Asn Leu Trp Gly Pro Glu Lys Thr Ile Thr Tyr Gln Gly 85 90 95 Cys Val Ala Gln Leu Tyr Ile Tyr Met Val Leu Gly Ser Thr Glu Cys 100 105 110 Val Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Arg 115 120 125 Pro Leu His Tyr Thr Val Val Met His Pro His Leu Cys Leu Gln Leu 130 135 140 Val Ile Val Ser Trp Phe Cys Gly Phe Leu Asn Ser Phe Val Met Cys 145 150 155 160 Pro Gln Thr Met Gln Leu Ser Arg Cys Gly Arg His Lys Val Asp His 165 170 175 Phe Leu Cys Glu Met Pro Ala Leu Ile Ala Met Ser Cys Glu Asp Thr 180 185 190 Met Leu Val Glu Ala Phe Ala Phe Val Leu Gly Val Ala Leu Leu Leu 195 200 205 Val Pro Leu Ser Leu Ile Leu Ile Ser Tyr Gly Met Ile Ser Ala Thr 210 215 220

Val Leu Arg Ile Lys Ser Ala Ala Gly Cys Lys Lys Ala Phe Asn Thr Page 2592

0 6926 »9_02 25_S iL.TX T 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Tyr Met Tyr Leu Gln Pro Ala Asn Ser Tyr Ser Gln Asp Gln Gly Lys 260 265 270 Phe Leu Thr Leu Phe Tyr Thr Ile Val Thr Pro Ser Val Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly Ala Met Arg Lys Leu 290 295 300 Leu Lys Gly Glu Lys Glu Asp Arg Glu Thr

305 310 <210> 2341 <211> 962 <212> DNA <213> Felis catus <400> 2341

tcagagccta atctgcagag cctccagatc cttgacagga gctttcttag ggctcccttt 60 acatccttgt tcctcagagt gtagataaaa ggattgaggg tgggggtgat tatggaatag 120 aagagggaga taaacttgcc ctgttcttgg gagtagctgg aagagggttg caggtacatg 180 tagatggctg gcaggtagaa gagggacacc accaccaggt gggaggaaca ggtcccaaag 240 gctttgtgcc ttcccctgga ggattggatc ctgagcactg ttcgggcaat gaagccatag 300 gagaaaagga tgagagctag gggaaccagc acaaagaagg ctaccagcac agccagtgtg 360 gtatcattca tggctgtgtc agcacatgac aacttaatca tggctggcac ctcacagaag 420 aagttgttca gcacctgccg cccacagaaa ggcagctgca ctgtcagcac tacctgaaca 480 agggagttgc caaagccact gagccaggcc acagccacga gctgttgaca gagaggatga 540 tgcatgataa cggcataccg gagaggctca cagatggcca catagcggtc cagcgccata 600 gcagccaaga caatgcactc agtgcatccc aaccagtgga aaattgcata ctgcattgtg 660 cagccaccat agctgatggt cttactggag ctccccatgt tgaccagcat ctgagggact 720

Page 2593

069269_0225_SL.TXT gtggtggtgg tatagcagag gtcgaggaag gataggtgcc cgagaaagat gtacatgggg ctgtggagct gagaatccag tcgagacacc aggatgatag caatgttccc caacatggcc agaatgtagg acaccaggag gaccacaaaa agagggagct ccagccatgg cctgtcagaa acacctagaa ggatgaagtc tttagggggt tcccgcagaa tgctgtggtt atgacctctc at

780

840

900

960

962 <210> 2342 <211> 321 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (321)..(321) <223> Any amino acid <400> 2342

Met Arg Gly His Asn His Ser Ile Leu Arg Glu Pro Pro Lys Asp Phe 1 5 10 15 Ile Leu Leu Gly Val Ser Asp Arg Pro Trp Leu Glu Leu Pro Leu Phe 20 25 30 Val Val Leu Leu Val Ser Tyr Ile Leu Ala Met Leu Gly Asn Ile Ala 35 40 45 Ile Ile Leu Val Ser Arg Leu Asp Ser Gln Leu His Ser Pro Met Tyr 50 55 60 Ile Phe Leu Gly His Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Thr 65 70 75 80 Thr Val Pro Gln Met Leu Val Asn Met Gly Ser Ser Ser Lys Thr Ile 85 90 95 Ser Tyr Gly Gly Cys Thr Met Gln Tyr Ala Ile Phe His Trp Leu Gly 100 105 110

Page 2594

069269_0225_SL.TXT

Cys Thr Glu 115 Cys Ile Val Leu Ala Ala Met Ala Leu Asp Arg Tyr Val 120 125 Ala Ile Cys Glu Pro Leu Arg Tyr Ala Val Ile Met His His Pro Leu 130 135 140 Cys Gln Gln Leu Val Ala Val Ala Trp Leu Ser Gly Phe Gly Asn Ser 145 150 155 160 Leu Val Gln Val Val Leu Thr Val Gln Leu Pro Phe Cys Gly Arg Gln 165 170 175 Val Leu Asn Asn Phe Phe Cys Glu Val Pro Ala Met Ile Lys Leu Ser 180 185 190 Cys Ala Asp Thr Ala Met Asn Asp Thr Thr Leu Ala Val Leu Val Ala 195 200 205 Phe Phe Val Leu Val Pro Leu Ala Leu Ile Leu Phe Ser Tyr Gly Phe 210 215 220 Ile Ala Arg Thr Val Leu Arg Ile Gln Ser Ser Arg Gly Arg His Lys 225 230 235 240 Ala Phe Gly Thr Cys Ser Ser His Leu Val Val Val Ser Leu Phe Tyr 245 250 255 Leu Pro Ala Ile Tyr Met Tyr Leu Gln Pro Ser Ser Ser Tyr Ser Gln 260 265 270 Glu Gln Gly Lys Phe Ile Ser Leu Phe Tyr Ser Ile Ile Thr Pro Thr 275 280 285 Leu Asn Pro Phe Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly Ala 290 295 300 Leu Arg Lys Leu Leu Ser Arg Ile Trp Arg Leu Cys Arg Leu Gly Ser 305 310 315 320

Page 2595

069269_0225_SL.TXT

Xaa <210> 2343 <211> 873 <212> DNA <213> Felis catus <400> 2343

atgaccctat ttatggcggt ttctgtcttt tacacagtca cactagtggg caacaccacc 60 atcatactcc tgtctcacct ggacccccac ctccacaccc ccatgtactt cttcctcacc 120 cacctctcca tcctggacct ctgctttacc accagctgca tccctcagat gctcgtgaat 180 ttctggagtt cggacaagac catcagctat ttggggtgtg cagtccagct ctacatcttc 240 ctgggactcg gagcttcaga atgtgttctg ctgctggtca tggccttcga ccgctatgtg 300 gcagtgtgcc ggcccctgca ctatgcagta atcatgcacc cacccctgtg tcacaagttg 360 gctttcctgg tctgggcaag tggggttttt ggcacattgg tgcagtctcc cactaccatg 420 aaactcccct tttgccatca ccaccaggtt gatgactttg tctgtgaggt ccctgcactg 480 atccgcctgg cttgtggaga cacacatgtc aatgagcttc agatctcagt gattggtgcc 540 atcttcctgc tggggcccct gctgctcatc cttgtctcct atggccgtat tacccaggca 600 gtgctggcca tccagtccca gaatggaagg attaaggcct tccatacctg ctcctcccac 660 ctggctgttg tttttctctt ctactgcagt gtcaccgctg tctatatcca accctgtagt 720 catttttccc agaaaggagg gaaatttcta actctcttct acactgtggt gacccccact 780 ctcaaccccc tcatctatac tttaaggaac aaggacatga agcaagcttt caggagactc 840 ctagggaaag gcagaatgtc cagtgaagag tga 873

<210> 2344 <211> 290 <212> PRT <213> Felis catus <400> 2344

Met Thr Leu Phe Met Ala Val Ser Val Phe Tyr Thr Val Thr Leu Val

1 5 10 15

Gly Asn Thr Thr Ile Ile Leu Leu Ser His Leu Asp Pro His Leu His

Page 2596

069269_0225_SL.TXT 25 30

Thr Pro Met Tyr 35 Phe Phe Leu Thr His 40 Leu Ser Ile Leu Asp Leu Cys 45 Phe Thr Thr Ser Cys Ile Pro Gln Met Leu Val Asn Phe Trp Ser Ser 50 55 60 Asp Lys Thr Ile Ser Tyr Leu Gly Cys Ala Val Gln Leu Tyr Ile Phe 65 70 75 80 Leu Gly Leu Gly Ala Ser Glu Cys Val Leu Leu Leu Val Met Ala Phe 85 90 95 Asp Arg Tyr Val Ala Val Cys Arg Pro Leu His Tyr Ala Val Ile Met 100 105 110 His Pro Pro Leu Cys His Lys Leu Ala Phe Leu Val Trp Ala Ser Gly 115 120 125 Val Phe Gly Thr Leu Val Gln Ser Pro Thr Thr Met Lys Leu Pro Phe 130 135 140 Cys His His His Gln Val Asp Asp Phe Val Cys Glu Val Pro Ala Leu 145 150 155 160 Ile Arg Leu Ala Cys Gly Asp Thr His Val Asn Glu Leu Gln Ile Ser 165 170 175 Val Ile Gly Ala Ile Phe Leu Leu Gly Pro Leu Leu Leu Ile Leu Val 180 185 190 Ser Tyr Gly Arg Ile Thr Gln Ala Val Leu Ala Ile Gln Ser Gln Asn 195 200 205 Gly Arg Ile Lys Ala Phe His Thr Cys Ser Ser His Leu Ala Val Val 210 215 220

Phe Leu Phe Tyr Cys Ser Val Thr Ala Val Tyr Ile Gln Pro Cys Ser Page 2597

0 6926 9_02 25_S L.TX T 225 230 235 240 His Phe Ser Gln Lys Gly Gly Lys Phe Leu Thr Leu Phe Tyr Thr Val 245 250 255 Val Thr Pro Thr Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp 260 265 270 Met Lys Gln Ala Phe Arg Arg Leu Leu Gly Lys Gly Arg Met Ser Ser 275 280 285

Glu Glu 290 <210> 2345 <211> 943 <212> DNA <213> Felis catus <400> 2345

tcagtgctgg ctgccaatcc tgcaatggtt cagacctttc ctcagggcct ccatcacgtc 60 ccgattcctc aaactataaa tgagggggtt gagcataggc gtaaggacca tgtagatgat 120 agagacaacc ttgtcatgac taggggcctg gtagcgccga ggcctcaggt agatgaacat 180 ggctgccctg tagaagagga agacagctgc taggtgggag gaacaggtgg ccagggcctt 240 tttacaggcc tgagcagagt gcatgtggag cacagccctc aggctgtgag cataggaggc 300 cactatgatg gaaaagggaa ggagcagcat gaagacacag aagcaaagag cagagtgtca 360 aaaagggttg tgtccataca ggccagtttt aataaagctg gtacctcaca gaagtaatcc 420 acattccttg agccacagta aggtaagctc atggctgcca ccatctggat aattccatct 480 agtatcccaa aggcccagga actcccagaa atctggagac agactctgac tcatgaggac 540 agtatagtga agggagtggc tgattgccac ataacaatca taggccatga gtcccagaaa 600 aattccctca gatcccacaa gagagacaaa aaaaccaatt tgtatgccac aacccacaaa 660 ggagatggac ttcctgccag agagaaaagt tgaccgccat ctttggcatg atattacaga 720 tcaaaataag atccataagg gagagctgac tgagaaagaa gtacatgggt gtgtgaagcc 780 aaggatctgt gtagatgagg aagatgaaga ggacattccc acagagggcc acagtgaaga 840

Page 2598

069269_0225_SL.TXT ctaccataac cacagagaag aggacaacac cagtctggct atgggaaaag atgcccaaga ggatgaagcc atctatagat gatcgattca accatatccc cat

900

943 <210> 2346 <211> 111 <212> PRT <213> Felis catus

<400> 2346 Asn Arg Ser Ser Ile Asp Gly Phe Ile Leu Leu Met Gly 1 Ile Trp Leu 5 10 15 Gly Ile Phe Ser His Ser Gln Thr Gly Val Val Leu Phe Ser Val Val 20 25 30 Met Val Val Phe Thr Val Ala Leu Cys Gly Asn Val Leu Phe Ile Phe 35 40 45 Leu Ile Tyr Thr Asp Pro Trp Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Gln Leu Ser Leu Met Asp Leu Ile Leu Ile Cys Asn Ile Met Pro 65 70 75 80 Lys Met Ala Val Asn Phe Ser Leu Trp Gln Glu Val His Leu Leu Cys 85 90 95 Gly Leu Trp His Thr Asn Trp Phe Phe Cys Leu Ser Cys Gly Ile 100 105 110

<210> 2347 <211> 948 <212> DNA <213> Felis catus <400> 2347 atggagatat ggttgaatca atcatccaca gacgacttca tcctcttggg cattttttct cacagtccaa ctgaccttgt cctcttctct gttgttatgg tggtcttcac agtggccctc tgtggtaatg tcctcctcct cttcctcatc tatggagatc ctcaacttca cacacccatg

120

180

Page 2599

069269_0225_SL.TXT

tacttcttcc tcagtcagct ctccctcatg gacctcatat tggtctgtac caatgtgccg 240 aagatggtgg tcaatttcct gactggcagg aagtccatct cctttgtggg ttgtggcata 300 caaattggcc tctttgtgtg tcttgtggga tctgaagggt tcttgctggg attcatggct 360 tatgaccgct atgtagccat tagccaccca cttcactatc ctgtcctcat gagtcagagg 420 gtctgtcttc aaattgttgg gagctcctgg gcctttggaa taatagatgg tgtgatacag 480 atggtggtag taatgacttt cccatactgt ggcttgagag aagtgaacca cttcttttgt 540 gagatgcttt ccttgttgaa actagcctgt atagacacat ccatttttga gaacgtgata 600 tatgcttgct gtgtcttcat gctgtttctt cccttctcaa tcaccatggc ctcctatgct 660 ttcatcctga gggctgtgct cctcatgcgc tctgctcagg caggcaagaa ggctctggcc 720 acctgttcct ctcacctaac agctgtctcc ctcttctacg gggcagccat gttcatctac 780 ctgaggcctc ggcgctaccg ggtgcctagt catgacaagg tggtctctat tttctacaca 840 gtccttactc ctatgctcaa ccccctcatt tatagcttga gaaaccgcga tgtgatgagg 900 gccctaagga aggggctgga ccattgcagg attagcagcc agcactga 948

<210> 2348 <211> 315 <212> PRT <213> Felis catus <400> 2348

Met Glu Ile Trp Leu Asn Gln Ser Ser Thr Asp Asp Phe Ile Leu Leu 1 5 10 15 Gly Ile Phe Ser His Ser Pro Thr Asp Leu Val Leu Phe Ser Val Val 20 25 30 Met Val Val Phe Thr Val Ala Leu Cys Gly Asn Val Leu Leu Leu Phe 35 40 45 Leu Ile Tyr Gly Asp Pro Gln Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Gln Leu Ser Leu Met Asp Leu Ile Leu Val Cys Thr Asn Val Pro 65 70 75 80

Page 2600

069269_0225_SL.TXT

Lys Met Val Val Asn 85 Phe Leu Thr Gly Arg Lys Ser Ile Ser Phe Val 90 95 Gly Cys Gly Ile Gln Ile Gly Leu Phe Val Cys Leu Val Gly Ser Glu 100 105 110 Gly Phe Leu Leu Gly Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser 115 120 125 His Pro Leu His Tyr Pro Val Leu Met Ser Gln Arg Val Cys Leu Gln 130 135 140 Ile Val Gly Ser Ser Trp Ala Phe Gly Ile Ile Asp Gly Val Ile Gln 145 150 155 160 Met Val Val Val Met Thr Phe Pro Tyr Cys Gly Leu Arg Glu Val Asn 165 170 175 His Phe Phe Cys Glu Met Leu Ser Leu Leu Lys Leu Ala Cys Ile Asp 180 185 190 Thr Ser Ile Phe Glu Asn Val Ile Tyr Ala Cys Cys Val Phe Met Leu 195 200 205 Phe Leu Pro Phe Ser Ile Thr Met Ala Ser Tyr Ala Phe Ile Leu Arg 210 215 220 Ala Val Leu Leu Met Arg Ser Ala Gln Ala Gly Lys Lys Ala Leu Ala 225 230 235 240 Thr Cys Ser Ser His Leu Thr Ala Val Ser Leu Phe Tyr Gly Ala Ala 245 250 255 Met Phe Ile Tyr Leu Arg Pro Arg Arg Tyr Arg Val Pro Ser His Asp 260 265 270 Lys Val Val Ser Ile Phe Tyr Thr Val Leu Thr Pro Met Leu Asn Pro 275 280 285

Page 2601

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Leu Ile Tyr Ser Leu Arg Asn Arg Asp Val Met Arg Ala Leu Arg Lys 290 295 300

Gly Leu Asp His Cys Arg Ile Ser Ser Gln His

305 310 315 <210> 2349 <211> 933 <212> DNA <213> Felis catus <400> 2349

ctatacctgc tctgtcccca tcaagctcct gactgctttc ttcacatcct tattcctcag 60 tgtgtagacc agagggttga gtgtgggcgc aagaatcatg taaagcactg ccagtgcttt 120 gctctggtcc tgggagtagt tgtccttggg ctgcagatac aaaaacataa tggtcccata 180 gaagagtgag actaccatta ggtgggaggc acaggtccca aaggcctttt tccttccctc 240 tgctgagcgc atttttacta ctgccctggc gatgcacacg taagtggtca ggatgatgga 300 gacaggcatg cctaggatga ttagccgggc aataaacatt ttagattctg tcgggccagt 360 atcaacgcag gagagtttaa caatgatcaa tagttcacag aagaaatggt ccacacgccg 420 gtttccacat agaggcagca ccatggccat tgaggactgg agaaaggagt tagcaaaacc 480 agaggaccag gaagctgctg ccaggaggtg gcacagcctg gggtgcatga tggaggtata 540 gtgtagaggc cagcaaactg caacatagcg atcaactgcc atcaccgcaa ggagcacaca 600 ctctgtggag ccaagtgcca aggccaccca gtactggacc atgcagccag catagctgat 660 ctttttgtta cctccccaca tgttcaccag catctggggc acaatgctgg tggtgaagca 720 gaggtcaagc acagagaggt ttctgaggaa gaagtacatg ggtgtatgaa gtccagcatc 780 caggatagaa agtaggatta tggccacgtt gcccacaaga gttatggtgt agaacatcag 840 gacaaagaaa gagaggatca gctctaactt gggccactca gagaagccca ctaagatgaa 900 atccccacct gtgctctcat tagctgtttc cat 933

<210> 2350 <211> 310 <212> PRT <213> Felis catus

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<400> 2350 Asn Glu Ser Thr Gly Gly Asp Phe Ile Leu Val 15 Gly Met 1 Glu Thr Ala 5 10 Phe Ser Glu Trp Pro Lys Leu Glu Leu Ile Leu Ser Phe Phe Val Leu 20 25 30 Met Phe Tyr Thr Ile Thr Leu Val Gly Asn Val Ala Ile Ile Leu Leu 35 40 45 Ser Ile Leu Asp Ala Gly Leu His Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Val Leu Asp Leu Cys Phe Thr Thr Ser Ile Val Pro Gln 65 70 75 80 Met Leu Val Asn Met Trp Gly Gly Asn Lys Lys Ile Ser Tyr Ala Gly 85 90 95 Cys Met Val Gln Tyr Trp Val Ala Leu Ala Leu Gly Ser Thr Glu Cys 100 105 110 Val Leu Leu Ala Val Met Ala Val Asp Arg Tyr Val Ala Val Cys Trp 115 120 125 Pro Leu His Tyr Thr Ser Ile Met His Pro Arg Leu Cys His Leu Leu 130 135 140 Ala Ala Ala Ser Trp Ser Ser Gly Phe Ala Asn Ser Phe Leu Gln Ser 145 150 155 160 Ser Met Ala Met Val Leu Pro Leu Cys Gly Asn Arg Arg Val Asp His 165 170 175 Phe Phe Cys Glu Leu Leu Ile Ile Val Lys Leu Ser Cys Val Asp Thr 180 185 190 Gly Pro Thr Glu Ser Lys Met Phe Ile Ala Arg Leu Ile Ile Leu Gly 195 200 205

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Met Pro Val Ser Ile Ile Leu Thr Thr Tyr Val Cys Ile Ala Arg Ala 210 215 220 Val Val Lys Met Arg Ser Ala Glu Gly Arg Lys Lys Ala Phe Gly Thr 225 230 235 240 Cys Ala Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr Ile Met 245 250 255 Phe Leu Tyr Leu Gln Pro Lys Asp Asn Tyr Ser Gln Asp Gln Ser Lys 260 265 270 Ala Leu Ala Val Leu Tyr Met Ile Leu Ala Pro Thr Leu Asn Pro Leu 275 280 285 Val Tyr Thr Leu Arg Asn Lys Asp Val Lys Lys Ala Val Arg Ser Leu 290 295 300 Met Gly Thr Glu Gln Val

305 310

<210> 2351 <211> 925 <212> DNA <213> Felis catus <400> 2351 ttctagaatt tgagatcagt ttccttaagg ctcccttcat atcacgattt ctcagactgt 60 agatgaaggg attgaccagg ggagtcacca ctgtgaagat gacagtggcc accgtgtctt 120 ggactgagta ggaggatgaa gggcgcatat agacccccag gattgcccca tagaagaggg 180 acaccacagt gagatgggat ccacatgtgg acagggattt ccttattcca tgggcagatg 240 gcaacttcag tacattagag aggatatacg catatgaaat gatgatacat gtaaatggtg 300 tcagaaatat cagtccaccc acagtgaata ccatcaggtc attgataaaa gtatcagaac 360 aagacagctt tagaactgca taggggtcac agaaaaagtg atgcacagta ttgttgaaac 420 aaaaggtgag tcggaccatg agaagagtgt gtaggagagc atgcaggttt gtaatgaccc 480

Page 2604

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aagagaccac caccagaagg atacagagtt tgggcttcat gatcatgctg tagtggagtg 540 ggcaacagat ggctacataa cggtcatagg ccatcacact cagaaggaac ccatccatgt 600 tgatgaaagt gatgaagaag tagatctggg tcatgcattc cacataagag ataaacttgc 660 ttcccagtat gtgattcagc agcatcttgg gggttgtgac tgatgaaaag cagatgtcga 720 tgcaggagag gttagccaag aagaagtaca tgggggtatg gagatgactg tcacagctga 780 tggccaggat gatgagaatg ttcccaatga tggtgaccag gtacatccac aagaacagcc 840 caaagagaat ctcttcctgc tttgactgcc cagagagtcc caggagaagg aattctgtga 900 ccgtagtctg gttgtctcta tccat 925

<210> 2352 <211> 309 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (309)..(309) <223> Any amino acid <400> 2352

Met Asp Arg Asp Asn Gln Thr Thr Val Thr Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Ser Gly Gln Ser Lys Gln Glu Glu Ile Leu Phe Gly Leu Phe Leu 20 25 30 Trp Met Tyr Leu Val Thr Ile Ile Gly Asn Ile Leu Ile Ile Leu Ala 35 40 45 Ile Ser Cys Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Cys Ile Asp Ile Cys Phe Ser Ser Val Thr Thr Pro Lys 65 70 75 80 Met Leu Leu Asn His Ile Leu Gly Ser Lys Phe Ile Ser Tyr Val Glu 85 90 95

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Cys Met Thr Gln 100 Ile Tyr Phe Phe Ile Thr Phe Ile Asn Met Asp Gly 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Cys 115 120 125 Pro Leu His Tyr Ser Met Ile Met Lys Pro Lys Leu Cys Ile Leu Leu 130 135 140 Val Val Val Ser Trp Val Ile Thr Asn Leu His Ala Leu Leu His Thr 145 150 155 160 Leu Leu Met Val Arg Leu Thr Phe Cys Phe Asn Asn Thr Val His His 165 170 175 Phe Phe Cys Asp Pro Tyr Ala Val Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190 Phe Ile Asn Asp Leu Met Val Phe Thr Val Gly Gly Leu Ile Phe Leu 195 200 205 Thr Pro Phe Thr Cys Ile Ile Ile Ser Tyr Ala Tyr Ile Leu Ser Asn 210 215 220 Val Leu Lys Leu Pro Ser Ala His Gly Ile Arg Lys Ser Leu Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Ala Ile Leu 245 250 255 Gly Val Tyr Met Arg Pro Ser Ser Ser Tyr Ser Val Gln Asp Thr Val 260 265 270 Ala Thr Val Ile Phe Thr Val Val Thr Pro Leu Val Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Arg Lys Leu Ile 290 295 300

Page 2606

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Ser Asn Ser Arg Xaa

305 <210> 2353 <211> 942 <212> DNA <213> Felis catus <400> 2353

atgtccaggg ggaaggagaa tgggacagga gtcaccgagt tcctcctgct tggcctcact 60 ggtgacccag agcagcagcg aatcctcttc tggctcttcc tgtgtacata cttggtcact 120 gtggctggga acacactcat catcctggcc atcggctctg acccccgcct gcacaccccc 180 atgtacttct tccttaccaa tctctccttt gttgacatct gcttcaccac caacctgatc 240 cccaagctgt tggtcaacca catagcagga acatggacaa tctcttaccc ccattgcctg 300 acccagatgt acttcctcat ctcctttgcc aacctggaca cctttctgct ggctgccatg 360 gccctggacc gttacgtggc catctgcaag cccctgcagt actacgccat catcaccccc 420 cagctctgtc ggggattgac cacactcgtg tggacatgct ctggcctcat ctccctagtc 480 cacacgctcc tcatgaacag actgacattc tgctcctgtg cccgcgagat ctcacacttc 540 tactgcgatg cctacctgct gatgaagatc gcctgctcgg acacgcgtgt caatcagcac 600 gtgttcctag gtgctgtggt cctgtttgtg gccccctctg cactcattgt ggtctcctac 660 atgtgcatag ttgcagctgt cctccggatt ccctccaccc caggaaggcg caaggcattt 720 tccacatgca gctcccatct gtctgtggtc atcgtgttct atggaactat cctgggggta 780 tatattcgac cccccaactc cttctcagct caggacacgg tagcaaccat catgtacaca 840 gtggtgaccc ccatgctaaa cccctttatc tacagcctga ggaaccaaga catgaagaag 900 gctatgggaa gtctcttcag caggagctca aaatcttctt ag 942

<210> 2354 <211> 313 <212> PRT <213> Felis catus <400> 2354

Met Ser Arg Gly Lys Glu Asn Gly Thr Gly Val Thr Glu Phe Leu Leu 1 5 10 15

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Leu Gly Leu Thr 20 Gly Asp Pro Glu Gln Gln Arg Ile Leu Phe Trp Leu 25 30 Phe Leu Cys Thr Tyr Leu Val Thr Val Ala Gly Asn Thr Leu Ile Ile 35 40 45 Leu Ala Ile Gly Ser Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Thr Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Thr Asn Leu Ile 65 70 75 80 Pro Lys Leu Leu Val Asn His Ile Ala Gly Thr Trp Thr Ile Ser Tyr 85 90 95 Pro His Cys Leu Thr Gln Met Tyr Phe Leu Ile Ser Phe Ala Asn Leu 100 105 110 Asp Thr Phe Leu Leu Ala Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Lys Pro Leu Gln Tyr Tyr Ala Ile Ile Thr Pro Gln Leu Cys Arg 130 135 140 Gly Leu Thr Thr Leu Val Trp Thr Cys Ser Gly Leu Ile Ser Leu Val 145 150 155 160 His Thr Leu Leu Met Asn Arg Leu Thr Phe Cys Ser Cys Ala Arg Glu 165 170 175 Ile Ser His Phe Tyr Cys Asp Ala Tyr Leu Leu Met Lys Ile Ala Cys 180 185 190 Ser Asp Thr Arg Val Asn Gln His Val Phe Leu Gly Ala Val Val Leu 195 200 205 Phe Val Ala Pro Ser Ala Leu Ile Val Val Ser Tyr Met Cys Ile Val 210 215 220

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Ala 225 Ala Val Leu Arg Ile Pro Ser Thr Pro Gly Arg Arg Lys Ala Phe 230 235 240 Ser Thr Cys Ser Ser His Leu Ser Val Val Ile Val Phe Tyr Gly Thr 245 250 255 Ile Leu Gly Val Tyr Ile Arg Pro Pro Asn Ser Phe Ser Ala Gln Asp 260 265 270 Thr Val Ala Thr Ile Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285 Phe Ile Tyr Ser Leu Arg Asn Gln Asp Met Lys Lys Ala Met Gly Ser 290 295 300 Leu Phe Ser Arg Ser Ser Lys Ser Ser 305 310

<210> 2355 <211> 918 <212> DNA <213> Felis catus <400> 2355

tggaacaaga aaaccaaacc cgaatttctg aatttagtcc cctcctggga ctgtcagacg 60 agcggggact gcagtcactg cgcttttggc cgttcctgtc catgtacctg gtcactttca 120 ctgggaacct gctcatgatc ctggccatta tcacagactc ccgcctccac acgcccatgt 180 acttcttcct ctccaacctg tccttttcag acatctgttt cacctccacc accgtcccaa 240 agatgctgct gaacatccag acgcagagca aagtgatcac ctatgaaggc tttctcagcc 300 agatgtactt tttcatggtt tttgcaggat tagacacctt cctcttgaca gtgatggcct 360 atgaccggtt tgtggccatc tgtcagccac tgcactacat ggtcatcatg aaccccaagt 420 tctgtggcat cctactcctg ggatcctaag gtgttgagtg ttctcgactc tctattacat 480 gacttattga ttttgcgact ctccttttgc acagagctgg aaatccttca ctttttctgt 540 gaacttaagc agatgatcca acttgcttgc tctgatacgt tcctcaatgt cctggtgacc 600

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tatctcacaa gtggacttct gagtgttgtt ccaatcgctg gtatcctgta ttcttactct 660 aagattgtag tctccgtttt gagaatttca tcaacgagtg gcaagtagaa agcattttcc 720 acgtgtgggt ctcacctctc agtggtctct ttgttctatg ctacaggcct tggggtgtat 780 ctgagttctg ctgctgcaca aaactccagg acaagtgcca tagcctcagt catgtgcacg 840 gtggtgacgc ccatgctgaa ccccttcatc tatggcctga ggaacagaga catcaaacaa 900 gccctgagaa agctcttt 918

<210> 2356 <211> 148 <212> PRT <213> Felis catus

<400> 2356 Thr Arg Ile Ser Glu Phe Ser Pro Leu Leu Gly Glu 1 Gln Glu Asn Gln 5 10 15 Leu Ser Asp Glu Arg Gly Leu Gln Ser Leu Arg Phe Trp Pro Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Phe Thr Gly Asn Leu Leu Met Ile Leu Ala 35 40 45 Ile Ile Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ser Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Gly 85 90 95 Phe Leu Ser Gln Met Tyr Phe Phe Met Val Phe Ala Gly Leu Asp Thr 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Gln 115 120 125

Pro Leu His Tyr Met Val Ile Met Asn Pro Lys Phe Cys Gly Ile Leu Page 2610

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130 135 140

Leu Leu Gly Ser

145 <210> 2357 <211> 918 <212> DNA <213> Felis catus <400> 2357 atggaaggaa gaaatcaaac tcatgttaca gaatttatcc tcctgggact ctccaaccag 60 ggggaacagc agtctctgct cttttgggtg ttcctgtcca tgtacctggt caccttcact 120 gggaacctgc tcatgatcct gaccattatc acagaccccc gcctccacac gcccatgtac 180 ttcttcctct ccaacctctc cttttcagac atctgtttca cctccaccac cgtcccaaag 240 atgctgctga acatccagac gcagagcaaa gtgatcacct atgaaggctg tctcagccag 300 atgtactttt tcatggtttt tgcaggatta gacaccttcc tcttgacagt gatggcctat 360 gaccggtttg tggccatctg tcggccactg cactacatgg tcatcatgaa ccccaagttc 420 tgtggcatcc tgctcctggt atgctggtta ttgagtattt ttaactctct attacatgac 480 ttgctgattt tgcaactctc tttttgcaca gatctggaaa tctatcactt tttctgtgaa 540 gttaagcagg tgatccaact tgcttgctct gataccttcc tcaatgacct aggaacatat 600 ctggcgagtg gatttctggg tggttttcca ctcactgtca tcctctcctc ctactctaga 660 attgtcactt ccattttgag aatttcatca gtgaggggca agtataaagc attttccacg 720 tgtgggtctc atctctcagt ggtctctttg ttctatggta caagccttgg ggtgtatctg 780 agttctgctg ctgcacaaaa ctccagggaa agtaccatag cctcagtcat gtacacagtg 840 gtgacgccca tgttgaaccc cttcatctat ggtctgagga acagagacat caagcaaggt 900 ctgagaaagc tctttagc 918 <210> 2358 <211> 306 <212> PRT <213> Felis catus <400> 2358

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Met 1 Glu Gly Arg Asn 5 Gln Thr His Val Thr Glu Phe Ile Leu Leu Gly 10 15 Leu Ser Asn Gln Gly Glu Gln Gln Ser Leu Leu Phe Trp Val Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Phe Thr Gly Asn Leu Leu Met Ile Leu Thr 35 40 45 Ile Ile Thr Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ser Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Gly 85 90 95 Cys Leu Ser Gln Met Tyr Phe Phe Met Val Phe Ala Gly Leu Asp Thr 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Met Val Ile Met Asn Pro Lys Phe Cys Gly Ile Leu 130 135 140 Leu Leu Val Cys Trp Leu Leu Ser Ile Phe Asn Ser Leu Leu His Asp 145 150 155 160 Leu Leu Ile Leu Gln Leu Ser Phe Cys Thr Asp Leu Glu Ile Tyr His 165 170 175 Phe Phe Cys Glu Val Lys Gln Val Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asp Leu Gly Thr Tyr Leu Ala Ser Gly Phe Leu Gly Gly 195 200 205

Page 2612

Phe Pro 210 Leu Thr Val Ile Leu 215 069269_0225_SL.TXT Ser Ser Tyr Ser Arg Ile 220 Val Thr Ser Ile Leu Arg Ile Ser Ser Val Arg Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Ala Gln Asn Ser Arg Glu Ser Thr 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Gly Leu Arg Asn Arg Asp Ile Lys Gln Gly Leu Arg Lys Leu 290 295 300

Phe Ser 305

<210> 2359 <211> 892 <212> DNA <213> Felis catus <400> 2359 gttacataat ttatcctcct cggactctca gatgaggggg ggctgcagtc acttctcttt 60 tggccattcc tgtccatgta cctggtcacc ttcactggga acctgatcat gatcctggcc 120 attatcacgg actcccgcct ccacacgccc atgtacttct tcctctccaa cctgtccttt 180 tcagacatct gtttcacctc caccaccgtc ccaaagatgc tgctgaacat ccagacgcag 240 agcaaagtga tcacctatga aggctgcctc agtcagatgt actttttcat gctttttgga 300 gtattagacc acttcctctt gacagtgatg gcctatgacc ggtttgtggc catctgtcac 360 ccactgcacc acatggtcat catgaacccc aagttctgtg gcatcctgct cctgggatcc 420 tggatactga gtgttcttga ctctctatta catgacttac tgattttgcg actctccttt 480 tgcacagagc tggaaatcct tcactttttc tgtgaattta atcaggtgat ccaacttgct 540

Page 2613

069269_0225_SL.TXT tgctctgata cgttcctcag tgacccgatg atctatctcg cagatggacc tctgtgtgtt 600 gttccactca ctggtatcct gctctctttc tccaagattg taacctccat tttgacaatt 660 tcatcagcca gcggcaatat acagcatttt tccatgtgtg ggtctcatct ctcagtggtc 720 tccttgttct gtaatatagg acttggggta tcttggtatt gatgcttcac aaaactccag 780 cgcatctgcc atagcctctg gcatgtacac gatcatgaca cccatgccta accccttcat 840 ctgtggtctg aggagcagag acatcaagca aggcctgaga aagctcttta gc 892 <210> 2360 <211> 77 <212> PRT <213> Felis catus

<400> 2360 Met Phe Ser Ser 1 Ile 5 Phe Gly Thr Val Val Glu Val Lys Gln Met Ser 10 15 Glu Lys Asp Arg Leu Glu Arg Lys Lys Tyr Met Gly Val Trp Arg Arg 20 25 30 Glu Ser Val Ile Met Ala Arg Ile Met Ile Arg Phe Pro Val Lys Val 35 40 45 Thr Arg Tyr Met Asp Arg Asn Gly Gln Lys Arg Ser Asp Cys Ser Pro 50 55 60 Pro Ser Ser Glu Ser Pro Arg Arg Ile Asn Tyr Val Thr 65 70 75

<210> 2361 <211> 918 <212> DNA <213> Felis catus <400> 2361 atggaaggaa gaaatcaaac tcatgttaca gaatttatcc tcctgggact ctcagaccag 60 ggggaacagc agtctctgct cttttggccg ttcctgtcca tgtacctggt caccttcact 120 gggaacctac tcatgatcct ggccattatc acggactctc gcctccacat gcccatgtac 180 ttcttcctct ccaacctgtc cttttcagac atctgtttca cctctgccac catcccaaag 240

Page 2614

069269_0225_SL.TXT atgctgctga acatccagac acagagcaga gcgatctcct acgaagggtg cctcagtcag atgtactttt tcatgctttt tggaggatta gaccactttc tcttgacagt gatggcctat gaccggttcg tggccatctg tcacccattg cactacatgg tcatcatgaa ccccaagttc tgtggcatcc tgctcctggg atcctggata ctgagtgttc ttgcctctct attacttgac ttactgattt tgcgactctc tttttgcaca aagctggaaa tccttcactt tttctgtgaa cttaagcagg tgatccaact tgcttgctcc gataggttcc tcaatgacct ggcagtgtat ttggtaagtg gacttctggg tgttgttcca ctcactggca tcctgttctc ttactctaga attgtcactt ccattttgag aatttcatca gtgaggggca agtataaagc attttccacg tgtgggtctc acctctcagt ggtctctttg ttctatgcta caggccttgg ggtgcatctg agttctgctg ctgcacaaaa ctccagggca agtgccatag cctcagtcat gtacacggtg gtgacgccca tgttgaaccc cttcatctat ggtctgagga acagagacat caagcaagcc ctgggaaaac tctttagc <210> 2362 <211> 306 <212> PRT <213> Felis catus <400> 2362

300

360

420

480

540

600

660

720

780

840

900

918

Met Glu Gly Arg Asn Gln Thr His Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Asp Gln Gly Glu Gln Gln Ser Leu Leu Phe Trp Pro Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Phe Thr Gly Asn Leu Leu Met Ile Leu Ala 35 40 45 Ile Ile Thr Asp Ser Arg Leu His Met Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ser Asp Ile Cys Phe Thr Ser Ala Thr Ile Pro Lys 65 70 75 80

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Met Leu Leu Asn Ile Gln Thr Gln Ser Arg Ala Ile Ser Tyr Glu Gly 85 90 95 Cys Leu Ser Gln Met Tyr Phe Phe Met Leu Phe Gly Gly Leu Asp His 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Met Val Ile Met Asn Pro Lys Phe Cys Gly Ile Leu 130 135 140 Leu Leu Gly Ser Trp Ile Leu Ser Val Leu Ala Ser Leu Leu Leu Asp 145 150 155 160 Leu Leu Ile Leu Arg Leu Ser Phe Cys Thr Lys Leu Glu Ile Leu His 165 170 175 Phe Phe Cys Glu Leu Lys Gln Val Ile Gln Leu Ala Cys Ser Asp Arg 180 185 190 Phe Leu Asn Asp Leu Ala Val Tyr Leu Val Ser Gly Leu Leu Gly Val 195 200 205 Val Pro Leu Thr Gly Ile Leu Phe Ser Tyr Ser Arg Ile Val Thr Ser 210 215 220 Ile Leu Arg Ile Ser Ser Val Arg Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Ala Thr Gly Leu 245 250 255 Gly Val His Leu Ser Ser Ala Ala Ala Gln Asn Ser Arg Ala Ser Ala 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285

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Ile Tyr Gly Leu Arg Asn Arg Asp Ile Lys Gln Ala Leu Gly Lys Leu 290 295 300

Phe Ser 305 <210> 2363 <211> 918 <212> DNA <213> Felis catus <400> 2363

atggaagaaa gaaatcaaac ctgtgtcaca caatttattc tcctgggact ctcagatgag 60 ggggggctgc agtcacttct cttttgggtg ttcctgtaca tgtacctggt caccttcact 120 gggaacctgc tcatgatcct ggccattatc acggactccc gcctccacac gcccatgtac 180 ttcttcctct ccaacctgtc cttttcagac atctgtttca cctccaccac cgtcccaaag 240 atgctgctga acatccagac gcagagcaaa gtgatcacct atgaaggctg cctcagccag 300 atgtactttt tcatgctttt tggagtatta gataacatac tcttgacagt gatggcctat 360 gaccggtttg tggccatctg tcagccactg cactacatgg tcatcatgaa ccccaagttc 420 tgtggcatcc tgctcctggt atgctggtta ttgggtgttt tttactctct attacttgac 480 ttactgattt tgcgactctc cttttgcaca gagctggaaa tccttcactt tttctgtgaa 540 cttaagcagg tgatccaact tgcttactct gatacgttcc tcaatgatct ggtgatgtat 600 ttgtcaagtg gacttctggg tgttgttcca ctcactggca tcctgttctc ttactctaga 660 attgtcactt ccattttgag aatttcatca gtgaggggca agtataaagc attttccacg 720 tgtgggtctc acctctcagt ggtctctttg ttctatggca catgccttgg ggtgtatctg 780 agttctgctg ctgcacaaaa ctccagggca agtgccatag cctcagtcat gtacacggtg 840 gtgacgccca tgttgaaccc cttcatctat ggtctgagga acagagacat caagcaagcc 900 ctgagaaatc tctttagc 918

<210> 2364 <211> 306 <212> PRT <213> Felis catus

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<400> 2364 Asn Gln Thr Cys Val Thr Gln Phe Ile Leu Leu 15 Gly Met 1 Glu Glu Arg 5 10 Leu Ser Asp Glu Gly Gly Leu Gln Ser Leu Leu Phe Trp Val Phe Leu 20 25 30 Tyr Met Tyr Leu Val Thr Phe Thr Gly Asn Leu Leu Met Ile Leu Ala 35 40 45 Ile Ile Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ser Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Gly 85 90 95 Cys Leu Ser Gln Met Tyr Phe Phe Met Leu Phe Gly Val Leu Asp Asn 100 105 110 Ile Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Gln 115 120 125 Pro Leu His Tyr Met Val Ile Met Asn Pro Lys Phe Cys Gly Ile Leu 130 135 140 Leu Leu Val Cys Trp Leu Leu Gly Val Phe Tyr Ser Leu Leu Leu Asp 145 150 155 160 Leu Leu Ile Leu Arg Leu Ser Phe Cys Thr Glu Leu Glu Ile Leu His 165 170 175 Phe Phe Cys Glu Leu Lys Gln Val Ile Gln Leu Ala Tyr Ser Asp Thr 180 185 190 Phe Leu Asn Asp Leu Val Met Tyr Leu Ser Ser Gly Leu Leu Gly Val 195 200 205

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Val Pro 210 Leu Thr Gly Ile Leu Phe Ser Tyr Ser Arg Ile Val Thr Ser 215 220 Ile Leu Arg Ile Ser Ser Val Arg Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Cys Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Ala Gln Asn Ser Arg Ala Ser Ala 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Gly Leu Arg Asn Arg Asp Ile Lys Gln Ala Leu Arg Asn Leu 290 295 300

Phe Ser 305

<210> 2365 <211> 918 <212> DNA <213> Felis catus <400> 2365 atggaaggaa gaaatcaaac ccgtgttaca gaatttatcc tcttggggct ctcagacgag 60 ggggggctgc agtccctgct cttttggctg ttcctgtcca tgtacctggt caccttcact 120 gggaacctgc tcatgatcct ggccattatc acggactccc gcctccacac gcccatgtac 180 ttcttcctct ccaacctgtc cttttcagac atctgtttca cctccaccac catcccaaag 240 atgctgctga acatccagac acagagcaaa gtgatcacct atgaaggctg tctcagccag 300 atgtactttt tcatgctttt tgtaggatta gacaacttcc tcttgacagt gatggcctat 360 gaccggttcg tggccatctg tcacccattg cactacatgg tcatcatgaa tcccaaattc 420 tgcagcattc tgcttctggt tccctggata ttgagtgttc ttacctctct attacatgac 480 ttgatgattt tgcgactctc tttttgcaca gatctggaaa tccttcactt tttctgtgaa 540

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cttattcagg tgatccaact tgcttgctct gataccttcc tcaatgacct gatgatctat 600 ctcacaagtg gacttctggg tgttgttcca ctcactggta tcctgttctc ttactataga 660 attgtaactt ccattttgag aatttcatca gcaatgggca agtataaagc attttccaca 720 tgtgggtctc atcttgcagt ggtctctttg ttctacggta caagccttgg ggtttatctt 780 agttttgctg cttcacaaaa ctccagagca agtgccatag cctcagtgat gttcacagtg 840 gtgacgccca tgctgaaccc ctttatctat ggtctgagga acagagacat caagcaagcc 900

ctgagaaatc tctttagc 918 <210> 2366 <211> 306 <212> PRT <213> Felis catus

<400> 2366 Gln Thr Arg Val Thr Glu Phe Ile Leu Leu Gly Met 1 Glu Gly Arg Asn 5 10 15 Leu Ser Asp Glu Gly Gly Leu Gln Ser Leu Leu Phe Trp Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Phe Thr Gly Asn Leu Leu Met Ile Leu Ala 35 40 45 Ile Ile Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ser Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Gly 85 90 95 Cys Leu Ser Gln Met Tyr Phe Phe Met Leu Phe Val Gly Leu Asp Asn 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125

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Pro Leu His 130 Tyr Met Val Ile Met Asn Pro Lys Phe Cys Ser Ile Leu 135 140 Leu Leu Val Pro Trp Ile Leu Ser Val Leu Thr Ser Leu Leu His Asp 145 150 155 160 Leu Met Ile Leu Arg Leu Ser Phe Cys Thr Asp Leu Glu Ile Leu His 165 170 175 Phe Phe Cys Glu Leu Ile Gln Val Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asp Leu Met Ile Tyr Leu Thr Ser Gly Leu Leu Gly Val 195 200 205 Val Pro Leu Thr Gly Ile Leu Phe Ser Tyr Tyr Arg Ile Val Thr Ser 210 215 220 Ile Leu Arg Ile Ser Ser Ala Met Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Phe Ala Ala Ser Gln Asn Ser Arg Ala Ser Ala 260 265 270 Ile Ala Ser Val Met Phe Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Gly Leu Arg Asn Arg Asp Ile Lys Gln Ala Leu Arg Asn Leu 290 295 300

Phe Ser 305 <210> 2367 <211> 900

Page 2621

<212> DNA <213> Felis catus 069269_0225_SL.TXT <400> 2367 atggaaggaa gaaatcaaac ccgtgttaca gaatttatcc tcttgggact ctcagatgag 60 ggggagctgc agtccctgct cttttggccg ttcctgtcca tgtacctggt caccttcact 120 gggaacctgc tcatgatcct ggccattatc acagactccc gcctccacac gcccatgtac 180 ttcttcctct ccaacctgtg cttttcagac atctgtttca cctccaccac cattccaaag 240 atgctgctga acatccagat gcagagcaaa gtgatctcct acaaaggttg tctcagccag 300 atgtactttt tcatgctttt tggagtatta gacaccttcc tcttgaccgt gatggcctat 360 gaccggtttg tggccatctg tcacccactg cactacatgg tcatcatgaa ccccaagttc 420 tgtggcatcc tgctcctggt atgctggtta ttgagtattt ttaactctct attacatgac 480 ttactgattt tgcgactctc tttttgcaca gatctggaaa tccttcactt tttctgtgaa 540 cttaatcagc tgatccaact tgcttgctct gataccttcc tcaatgacct gatgatctat 600 ctcacaagtg gatttctggg tgttgttcca ctcactggta tcctgttctc ttactctaga 660 attgtcactt ccattttgag aatttcatca gtgaggggca agtataaagc attttccacg 720 tgtgggtctc acctctcagt ggtctctttg ttctatggta caagccttgg ggtgtatctg 780 agttctgctg ctgcacaaaa ctccaggaca agtgccatag cctcagtcat gtacacagtg 840 gtggcaccca tgctgaaccc cttcatctat ggcctgaaga acagagacat caagcaagcc 900

<210> 2368 <211> 300 <212> PRT <213> Felis catus <400> 2368

Met 1 Glu Gly Arg Asn Gln Thr Arg Val Thr Glu Phe Ile Leu Leu Gly 5 10 15 Leu Ser Asp Glu Gly Glu Leu Gln Ser Leu Leu Phe Trp Pro Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Phe Thr Gly Asn Leu Leu Met Ile Leu Ala 35 40 45

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Ile Ile 50 Thr Asp Ser Arg Leu His 55 Thr Pro Met Tyr Phe Phe Leu 60 Ser Asn Leu Cys Phe Ser Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Met Gln Ser Lys Val Ile Ser Tyr Lys Gly 85 90 95 Cys Leu Ser Gln Met Tyr Phe Phe Met Leu Phe Gly Val Leu Asp Thr 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Met Val Ile Met Asn Pro Lys Phe Cys Gly Ile Leu 130 135 140 Leu Leu Val Cys Trp Leu Leu Ser Ile Phe Asn Ser Leu Leu His Asp 145 150 155 160 Leu Leu Ile Leu Arg Leu Ser Phe Cys Thr Asp Leu Glu Ile Leu His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Leu Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asp Leu Met Ile Tyr Leu Thr Ser Gly Phe Leu Gly Val 195 200 205 Val Pro Leu Thr Gly Ile Leu Phe Ser Tyr Ser Arg Ile Val Thr Ser 210 215 220 Ile Leu Arg Ile Ser Ser Val Arg Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Ser Leu 245 250 255

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Gly Val Tyr Leu Ser Ser Ala Ala Ala Gln Asn Ser Arg Thr Ser Ala 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Val Ala Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Gly Leu Lys Asn Arg Asp Ile Lys Gln Ala 290 295 300

<210> 2369 <211> 919 <212> DNA <213> Felis catus <400> 2369

atggaatcag aaaatcaaac atgtgtttca gaatttatcc tcctgggtgt ctcagaagat 60 gtattactcc agcccctcct ctttggactg tttttgtcca tgtatctggt cacatccatt 120 gggaacctgc tcatcatcgt ggccgttatc atggactccc acctccacac gcccatgtac 180 ttctttctct ccaatctctc tttggcagac atctgtttca tctccaccac catccctaag 240 atgctactga acatccagac acagagcaaa gtcattacct atgcaggatg catcacccag 300 ttgtactttt tcatgctttt tggagttctg gacaacttcc tcctgactgt gatggcctat 360 gaccggtttg tggccatctg tcaccccctc cactacacga tcatcatgaa cccccgcctc 420 tgtgggctcc tgcttctggc atcctggatc atgactgccc tgcactcatt gttacagagc 480 ttaatggttt tgcgactctc tttttgtgaa gagttggaaa tccctcattt tttctgtgaa 540 cttaatcagc taatccatct tgcttgttct gatacttttc tcaacgattt ggtgatgtat 600 tttgctactg gccttgtagc tattgttcca ctcacaggga tcctcttctc ttactctaag 660 attgtaacct ccatttccag aatttcatca gctggaggca agtacaaagc attttctaca 720 tgtgggtctc acctctcagt tgtctccttg ttctatggca caagccttgg ggtgtatctg 780 agttctgctg ctgcacaaaa ctccagggcc agtgccatag cctcagtcat gtacacagtg 840 gtcaccccca tgctgaaccc ttttatctat agtctaaaac aacaaggaca taaagcaagc 900 ccttaaaaag ctcttcagc 919

Page 2624

069269_0225_SL.TXT <210> 2370 <211> 301 <212> PRT <213> Felis catus

<400> 2370 Ile Leu Leu 15 Gly Met 1 Glu Ser Glu Asn Gln Thr Cys 5 Val Ser 10 Glu Phe Val Ser Glu Asp Val Leu Leu Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Ser Ile Gly Asn Leu Leu Ile Ile Val Ala 35 40 45 Val Ile Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Leu Ala Asp Ile Cys Phe Ile Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Leu Tyr Phe Phe Met Leu Phe Gly Val Leu Asp Asn 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Ile Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Leu Leu Ala Ser Trp Ile Met Thr Ala Leu His Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Val Leu Arg Leu Ser Phe Cys Glu Glu Leu Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Leu Ile His Leu Ala Cys Ser Asp Thr 180 185 190

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Phe Leu Asn Asp Leu Val 195 Met Tyr Phe Ala Thr Gly Leu Val Ala Ile 200 205 Val Pro Leu Thr Gly Ile Leu Phe Ser Tyr Ser Lys Ile Val Thr Ser 210 215 220 Ile Ser Arg Ile Ser Ser Ala Gly Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Ala Gln Asn Ser Arg Ala Ser Ala 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Lys Gln Gln Gly His Lys Ala Ser Pro 290 295 300

<210> 2371 <211> 969 <212> DNA <213> Felis catus <400> 2371 tcatgggaaa ttcttcaacc gcaggacaat tggacctttt ctaactgcca ttgcagagaa 60 tctcctcaga gcccccttta ggtctttgtt cctcaggctg tagatgaagg ggttcagcat 120 gggcgtgacc accgtgtaca tcaccgaggc tgtggcactt gagtgggagc tctgggtggc 180 agcagagctg aggtacacac ctaggctcgt acaaaaaaat aaggagacaa ctaaaaggtg 240 agatgcgcag gtggaaaatg ctttatactt gccctgagct gaggagatcc cacgtatgga 300 ggaaactatc ttggagtaag agtaaagtat cccaacgagg ggaccaccag ccagcaacac 360 agctgcaaga tacatcacca agttattaag aaaggtgtca gaacaggcaa gttggatcaa 420 ctgattgagt tcacataaaa agtgggggat ttctacttct gtacagaagg acagccgcaa 480

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caccattgaa gtttgcaaca aggaatgcag gacactcgtg atccaggaca ccaggaccag 540 cagcccacag agccgggggt tcatgatgac cgtgtattgc agggggtgac agatggccac 600 aaatctgtca taggccatca cagccaggag atagatgtcc aacactgaaa agattaagaa 660 aaagttcatc tgggtgatgc agtcctcata ggttatgatt ttgctctgtg tctggatgtt 720 caagagcatc ttcgggacgg tggtggaggt gaagcagatg tctacaaagg acaggttggc 780 caggaagaag tacatggggg tgtggaggtg ggagtcagag ctgacaacca ggatgatgag 840 caggttccca aacacagtga tcaggtacat ggaaaggaaa agcccaaata tgaggggctg 900 cagttctgga ccgtctgaaa atcccagaag cagaaattct aatagtcgtg tatcgtttcc 960

tggttccat 969 <210> 2372 <211> 322 <212> PRT <213> Felis catus <400> 2372

Met Glu Pro Gly Asn Asp Thr Arg Leu Leu Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Asp Gly Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Val 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Ile Ile Thr Tyr Glu Asp 85 90 95 Cys Ile Thr Gln Met Asn Phe Phe Leu Ile Phe Ser Val Leu Asp Ile 100 105 110

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Tyr Leu Leu 115 Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 120 125 Pro Leu Gln Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Thr Ser Val Leu His Ser Leu Leu Gln Thr 145 150 155 160 Ser Met Val Leu Arg Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175 Phe Leu Cys Glu Leu Asn Gln Leu Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Leu Val Met Tyr Leu Ala Ala Val Leu Leu Ala Gly 195 200 205 Gly Pro Leu Val Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Leu Val Val Ser Leu Phe Phe Cys Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Leu Lys Gly Ala Leu Arg Arg Phe 290 295 300 Ser Ala Met Ala Val Arg Lys Gly Pro Ile Val Leu Arg Leu Lys Asn 305 310 315 320

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Phe Pro <210> 2373 <211> 928 <212> DNA <213> Felis catus <400> 2373

ggaactaggc aacaatacac gaagttcaga atttcttctt ctgggacttt cagaggaacc 60 agagttgcaa cccttcctct ttgggctgtt cctgtccatg tacttggtca ccatacatgg 120 gaatctgctc atcatcctgg ctgtaaactc tgactcccac ctccacacgc ccatgtactt 180 cttcctcgcc aacctgtcct ttgtagacat ctgtgtcact tccaccacag tccccaagat 240 gctggtgaat atacaaacac agagaaaggt cataacttat gaaagctgta tcacgcaggt 300 atactttttc atactctttg tagttttgga caatttcctc ctgactgtga tggcatatga 360 ccgctttgta gccatctgtc accccctgtg ctacacagtc atcatgaacc ccaagttctg 420 tgggctgctg gttctggtgt cttggatcgt gagtgtcctg aattccttgt tacaaacctt 480 aatggtgttg cagctgtcct tctgtacaga catggaaatc ccccactttt tctgtgaact 540 caatcagatg atccaacttg cctattctga cacctttctt aatgacatgg taacttgttt 600 tacaactgtg ctgttgggtg gtgctcccct ggctggggtc ctttactctt attctaagat 660 agtttcctcc atatgtggga tctcatcagc tcagggcaag tataaagcat tttccacctg 720 tgcatctcac ctctcggttg tctccttatt ttattgtacc agcctaggtg tgtactttag 780 ctctgctgct tcccagagct cccactcaag tgccacggcc tcggtgatgt acacggtggt 840 cacacccatg ctgaacccct tcatctacag cctgaggaac agagacataa aggaggctct 900 aaatgtattt ttcagaggga agccataa 928

<210> 2374 <211> 308 <212> PRT <213> Felis catus <400> 2374

Glu Leu Gly Asn Asn Thr Arg Ser Ser Glu Phe Leu Leu Leu Gly Leu 1 5 10 15

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Ser Glu Glu Pro Glu Leu 20 Gln Pro Phe Leu Phe Gly Leu Phe Leu Ser 25 30 Met Tyr Leu Val Thr Ile His Gly Asn Leu Leu Ile Ile Leu Ala Val 35 40 45 Asn Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn 50 55 60 Leu Ser Phe Val Asp Ile Cys Val Thr Ser Thr Thr Val Pro Lys Met 65 70 75 80 Leu Val Asn Ile Gln Thr Gln Arg Lys Val Ile Thr Tyr Glu Ser Cys 85 90 95 Ile Thr Gln Val Tyr Phe Phe Ile Leu Phe Val Val Leu Asp Asn Phe 100 105 110 Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro 115 120 125 Leu Cys Tyr Thr Val Ile Met Asn Pro Lys Phe Cys Gly Leu Leu Val 130 135 140 Leu Val Ser Trp Ile Val Ser Val Leu Asn Ser Leu Leu Gln Thr Leu 145 150 155 160 Met Val Leu Gln Leu Ser Phe Cys Thr Asp Met Glu Ile Pro His Phe 165 170 175 Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Tyr Ser Asp Thr Phe 180 185 190 Leu Asn Asp Met Val Thr Cys Phe Thr Thr Val Leu Leu Gly Gly Ala 195 200 205 Pro Leu Ala Gly Val Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser Ile 210 215 220

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Cys Gly 225 Ile Ser Ser Ala Gln 230 Gly Lys Tyr Lys Ala Phe Ser Thr Cys 235 240 Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Ser Leu Gly 245 250 255 Val Tyr Phe Ser Ser Ala Ala Ser Gln Ser Ser His Ser Ser Ala Thr 260 265 270 Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Arg Asp Ile Lys Glu Ala Leu Asn Val Phe Phe 290 295 300

Arg Gly Lys Pro 305 <210> 2375 <211> 863 <212> DNA <213> Felis catus <400> 2375

tcatgggtac ttttcagcac aagacaattg gcccttttat agctgccata ccagagaatc 60 tcatcagagg aactaatgtc tttgttcctc aggctataga tgagggggtt cagtatgggt 120 gtgaccacca tgtacatcac cgagcctgtt gcacttgagt gggagctctg ggtagcagca 180 gagctgaggt acactcctag gcttgtacag taaaataaag agaccactga aaggtgagac 240 acacaggtgg aaaatgcttt atactttccc tgagctgatg aaatcccacg tatgaaggaa 300 attatcttat agtaagagta aaggatccca aaaaagggac caccagccag cagaatagct 360 ccaaaataca ccaccatgtt attgagaaag gtgtcaggac agacaagttg gatcatcgga 420 ttgagctcac agaaaaagtg ggggatttcc cagactgtac agaaggacag ctgcaacacc 480 attaagcttt ctaacaagga atgcagagca ctccaggacc aggagtccac agagccagga 540 gctcataatg accatgtagt ttaccgggtg gcagatggcc acaaacctgt cgtaggccat 600

Page 2631

069269_0225_SL.TXT cacactcagg agaaagtcgt ccatccctgc aaaggttatg aaaaagttca tttgtgtgat acagtcctca taggttatga ctttgctctg ggtctggatg ttccagagca tcttcaggac ggtggtggag gtgaagcaga tgtctacaaa ggacaggttg gccaggaaga agtacatggg ggtgtggagg tgggagtcag agctgacggc caggaggatg agcaggttcc caaacacagt gatcaggtac atggaaagga aaa

660

720

780

840

863 <210> 2376 <211> 163 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (163)..(163) <223> Any amino acid

<400> 2376 Val Ser Gly Gln Thr Ser Trp Ile Ile Gly Leu Met Leu 1 Leu Arg Lys 5 10 15 Ser Ser Gln Lys Lys Trp Gly Ile Ser Gln Thr Val Gln Lys Asp Ser 20 25 30 Cys Asn Thr Ile Lys Leu Ser Asn Lys Glu Cys Arg Ala Leu Gln Asp 35 40 45 Gln Glu Ser Thr Glu Pro Gly Ala His Asn Asp His Val Val Tyr Arg 50 55 60 Val Ala Asp Gly His Lys Pro Val Val Gly His His Thr Gln Glu Lys 65 70 75 80 Val Val His Pro Cys Lys Gly Tyr Glu Lys Val His Leu Cys Asp Thr 85 90 95 Val Leu Ile Gly Tyr Asp Phe Ala Leu Gly Leu Asp Val Pro Glu His 100 105 110

Leu Gln Asp Gly Gly Gly Gly Glu

Ala Asp Val Tyr

Lys Gly Gln Val

Page 2632

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115 120 125 Gly Gln Glu Glu Val His Gly Gly Val Glu Val Gly Val Arg Ala Asp 130 135 140 Gly Gln Glu Asp Glu Gln Val Pro Lys His Ser Asp Gln Val His Gly 145 150 155 160

Lys Glu Xaa <210> 2377 <211> 894 <212> DNA <213> Felis catus <400> 2377

ttttatgtct ctgttcctca ggctgtagat gaaggggttc agcatgggcg tgaccaccgt 60 gtacatcacc gaggctgtgg cacttgagtg ggagctctgg gtggcagcag agctgaggta 120 cactcccagg ccagtacaat aaaatagaga gacaaccaag aggtgagatg cacaggtgga 180 aaatgctctg tacttgcctt gagctgatga gatcccacat atggaggaga ctatcttaga 240 ataagagtaa aggaccccag ccaggggagc accacccagc agcacagttg caaaatacat 300 catcatgtca ttaagaaagg tgtcagaaca ggcaagttgg atcatctgat tgagttcaca 360 gaaaaagtgg gggatttcca tgtctgtaca gaaggacagc tgcaacacca ttaaggtttg 420 taacaaggaa tttgtaacac tgatgatcca ggacaccaga acaagcaatc cacagagctg 480 ggggttcatg atgacggtgt agtgcagggg gtgacagatg gccacaaacc ggtcataggc 540 cattgcagat aggagaaagt catccagttc tgcacagagt aagaaaaaat acatctggct 600 aatgcagcct gcatagttaa tgaccttgct ctgagtctgg gtgttcagaa gcatcttcgg 660 gacagtggtg gacgtgtagc agatgtccga aaaggacagg ttggccagga agaagtacat 720 gggggtgtgg aggtgggagt cagagctgat ggccaggatg atgagcaggt ttccaaacac 780 agtgatcagg tacatggaga ggaaaagccc aaatatgagg ggccgtaatg ctggttcctc 840 tgaaaatccc agaagaagaa actttgaaat gtgtgtatca ttgcctagtt ccat 894

Page 2633

069269_0225_SL.TXT <210> 2378 <211> 298 <212> PRT <213> Felis catus

<400> 2378 Leu Leu Leu 15 Gly Met 1 Glu Leu Gly Asn Asp Thr His 5 Ile Ser 10 Lys Phe Phe Ser Glu Glu Pro Ala Leu Arg Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Ser Asp Ile Cys Tyr Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Thr Gln Thr Gln Ser Lys Val Ile Asn Tyr Ala Gly 85 90 95 Cys Ile Ser Gln Met Tyr Phe Phe Leu Leu Cys Ala Glu Leu Asp Asp 100 105 110 Phe Leu Leu Ser Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Gln Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Ile Ser Val Thr Asn Ser Leu Leu Gln Thr 145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Thr Asp Met Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190

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Phe Leu Asn Asp Met Met Met Tyr Phe Ala Thr Val Leu Leu Gly Gly 195 200 205 Ala Pro Leu Ala Gly Val Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Cys Gly Ile Ser Ser Ala Gln Gly Lys Tyr Arg Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Leu Val Val Ser Leu Phe Tyr Cys Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys

290 295 <210> 2379 <211> 933 <212> DNA <213> Felis catus <400> 2379

caagcaatga aacaaaattt tcaaagtttc ttcttctggg attttcagag gaaccagaac 60 tgcagcccct catatttggg cttttcctct ccatgtacct gatcactgtg tttggaaacc 120 tgctcatcat cttggccatc agcacagacc ccaacctcca cacgcccatg tacttcttcc 180 tggccaacct gtcctttgta gacatctgct tcacctccac caccgtgccg aagatgctgg 240 tgaacatcca gactcagagc aaagtcataa cctatgcagg ctgtatcaca cagatttatt 300 ttctcatact ctttgctgtg atggacgtct tcctcctgag tgtgatggcc tatgaccggt 360 ttgtggccat ccgtcacccc ctgcactaca cgatcattgt gaacccccgg ctctgtgggc 420 tgctggttct tgtgtcctgg atcatgtgtg tcctgcattc cctgttacaa agtttaatga 480

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tgttgcggct gtccttctgt acacacttgc atatccccca ctttttttgt gaacttaatc 540 agatgctcca actggcctgt tctgatacct ttcttaataa cgtggtgatg tatcttgcag 600 ctgtcttgtt ggctggtggt cccttcattg ggatccttta ctcttactct aagatagttt 660 cctccatatg tcggatctca tcagctcagg gaaagtgtaa agcattttct acctgtgcat 720 ctcatctatc ggttgtctcc ttattttatt gtacgatgct cggcgtgtac cttagctctg 780 ctgctaccca cagctcacgg tcaagtgcca cagcctcggt gatgtacacg gtggtcacgc 840 ccatgctgaa ccccttcatc tacagcttga ggaacaaaga catgaaaagg gctctgaaag 900 cattctttgg gaaagagacc cttacaggcc aat 933

<210> 2380 <211> 311 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (311)..(311) <223> Any amino acid <400> 2380

Ser Asn Glu Thr Lys Phe Ser Lys Phe Leu Leu Leu Gly Phe Ser Glu 1 5 10 15 Glu Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu Ser Met Tyr 20 25 30 Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala Ile Ser Thr 35 40 45 Asp Pro Asn Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser 50 55 60 Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys Met Leu Val 65 70 75 80 Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly Cys Ile Thr 85 90 95

Page 2636

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Gln Ile Tyr Phe 100 Leu Ile Leu Phe Ala Val Met Asp Val Phe Leu Leu 105 110 Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Arg His Pro Leu His 115 120 125 Tyr Thr Ile Ile Val Asn Pro Arg Leu Cys Gly Leu Leu Val Leu Val 130 135 140 Ser Trp Ile Met Cys Val Leu His Ser Leu Leu Gln Ser Leu Met Met 145 150 155 160 Leu Arg Leu Ser Phe Cys Thr His Leu His Ile Pro His Phe Phe Cys 165 170 175 Glu Leu Asn Gln Met Leu Gln Leu Ala Cys Ser Asp Thr Phe Leu Asn 180 185 190 Asn Val Val Met Tyr Leu Ala Ala Val Leu Leu Ala Gly Gly Pro Phe 195 200 205 Ile Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser Ile Cys Arg 210 215 220 Ile Ser Ser Ala Gln Gly Lys Cys Lys Ala Phe Ser Thr Cys Ala Ser 225 230 235 240 His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Met Leu Gly Val Tyr 245 250 255 Leu Ser Ser Ala Ala Thr His Ser Ser Arg Ser Ser Ala Thr Ala Ser 260 265 270 Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser 275 280 285 Leu Arg Asn Lys Asp Met Lys Arg Ala Leu Lys Ala Phe Phe Gly Lys 290 295 300

Page 2637

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Glu Thr Leu Thr Gly Gln Xaa 305 310 <210> 2381 <211> 969 <212> DNA <213> Felis catus <400> 2381

atggaaccag gaaatattac acggatatca aaatttcttc tcctgggatt ttcagtgaga 60 ccagaactgc agcccctcat atttggactt ttcctctcca tgtacctgat cactgtgttt 120 ggcaacctgc tcatcatcct ggccgtcagc tctgactccc gcctccacac ccccatgtac 180 ttcttcctgg ccaacctgtc ctttgtagac atctgcttca cctccaccac agtcccgaag 240 atgctggtga acatccagac ccagagcaac atcataaccc atgaggactg catcacacaa 300 atgaacttct tcataatctt ttcagggttg gacatctatc tcctggctgt gatggcctat 360 gaccggtttg tggccatctg tcaccccctg cactataagg tcatcatgaa cccccggctc 420 tgtgggctgc tggtcctggt gtcctggatc acaagtatcc tgcattcctt gttacaaact 480 tcaatggtgt tgcagctgtc cttctgtaca gaggtagaaa tcccccactt tttctgtgaa 540 ctcaatcagt tgatccaact tgcctgttct gacacctttc ttaataactt ggtgatgtac 600 cttgcagcta tgctgctggc tggaggtccc cttgctggga tcctttactc ttattctaag 660 atagtttcca ccataattgg aatctcatca gctcagggaa agtataaagc gttttccacc 720 tgtgtatctc atcttttagt tgtatcttta tttttttgta cgagcctagg tgtgtacctc 780 agctctgctg ccacccagag ctcccactca agtgccacag cctcggtgat gtacacggtg 840 gtcacgccca tgctgaaccc cttcatctac agcctgagga acaaagacct aaaggtggtt 900 cttaaaagaa tcattgggat ttcattgacg tgagggccaa tcatattagg gctgaagacg 960

tgcccatga 969 <210> 2382 <211> 310 <212> PRT <213> Felis catus <400> 2382

Page 2638

069269_0225_SL.TXT

Met 1 Glu Pro Gly Asn 5 Ile Thr Arg Ile Ser Lys Phe Leu Leu Leu Gly 10 15 Phe Ser Val Arg Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr Gln Ser Asn Ile Ile Thr His Glu Asp 85 90 95 Cys Ile Thr Gln Met Asn Phe Phe Ile Ile Phe Ser Gly Leu Asp Ile 100 105 110 Tyr Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Lys Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Thr Ser Ile Leu His Ser Leu Leu Gln Thr 145 150 155 160 Ser Met Val Leu Gln Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Leu Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Leu Val Met Tyr Leu Ala Ala Met Leu Leu Ala Gly 195 200 205

Page 2639

Gly Pro 210 Leu Ala Gly Ile Leu 215 069269_0225_SL.TXT Tyr Ser Tyr Ser Lys Ile 220 Val Ser Thr Ile Ile Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Val Ser His Leu Leu Val Val Ser Leu Phe Phe Cys Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Leu Lys Val Val Leu Lys Arg Ile 290 295 300 Ile Gly Ile Ser Leu Thr 305 310

<210> 2383 <211> 969 <212> DNA <213> Felis catus <400> 2383 atggaaccag gaaatgatac acgactatta gaatttctgc ttctgggatt ttcagaggga 60 ccagaacttc agcccctcat atttgggctt ttcctctcca tgtacctgat cactgtgttt 120 gggaacctgc tcatcctcct ggccgtcagc tctgactccc acctccacac ccccatgtac 180 ttcttcctgg ccaacctgtc ctttgtagac atctgcatca cctccacaat catcccgaag 240 atgctggtga acatccagac tcagagtaaa gttataacct atgacgactg catcacacag 300 atggactttt tcttaatctt ttcagtgttg gacatgtatc tcctgaccat gatggcctat 360 gacaggtttg tggccatctg tcaccccctg cactacacag tcatcatgag ccctcggctc 420 tgtgcactgc tggtcctggt gtcctggatc atgagtgtcc tgcattcctt gttacaaacc 480 ttaatggtgt tgcagctgtc cttctgtaca gaggtagaaa tcccccactt tttttgtgaa 540

Page 2640

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ctcaatcaga tgacccaact ggcttgttct gacacctttt ttaataactt ggtgatgtat 600 cttgcagcta tgctgctagg tggtggtccc ttcattggga tcctttactc ttactccaag 660 atagctttct gcatacagag aatctcatca gctcagggga agtataaagc attttccacc 720 tgtgcaactc acctctccgt tgtctctcta ttttattgta ctggcctggg agtgtacctc 780 agctctgctg ctacccaggg ctcccactcg agtgccacag cctcggtgat gtacacggtg 840 gtcacgccca tgctgaaccc cttcatctac agcctgagga acagagacat aaaggaggct 900 ctgaggagat tctctgggat ggtagctata aaagttccaa ttgtcctggg gttgaagaat 960

ttcccatga 969 <210> 2384 <211> 322 <212> PRT <213> Felis catus <400> 2384

Met Glu 1 Pro Gly Asn Asp Thr Arg Leu Leu Glu Phe Leu Leu Leu Gly 5 10 15 Phe Ser Glu Gly Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Ile Thr Ser Thr Ile Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Asp Asp 85 90 95 Cys Ile Thr Gln Met Asp Phe Phe Leu Ile Phe Ser Val Leu Asp Met 100 105 110 Tyr Leu Leu Thr Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Page 2641

069269_0225_SL.TXT

115 120 125 Pro Leu His Tyr Thr Val Ile Met Ser Pro Arg Leu Cys Ala Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Met Ser Val Leu His Ser Leu Leu Gln Thr 145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Thr Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Phe Asn Asn Leu Val Met Tyr Leu Ala Ala Met Leu Leu Gly Gly 195 200 205 Gly Pro Phe Ile Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Ala Phe Cys 210 215 220 Ile Gln Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Thr His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Gly Ser His Ser Ser Ala 260 265 270 Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Glu Ala Leu Arg Arg Phe 290 295 300 Ser Gly Met Val Ala Ile Lys Val Pro Ile Val Leu Gly Leu Lys Asn 305 310 315 320

Phe Pro

Page 2642

069269_0225_SL.TXT <210> 2385 <211> 959 <212> DNA <213> Felis catus <400> 2385

atggaaccag gaaatgatac acggacatca gaatttctgc ttctgggatt ttcagacagt 60 ccagaacagc aacccctcat atttgggctt ttcctctcca tgtacctgat cactgtgttt 120 gggaacctgc tcatcatcct ggccgtcagc tatgactccc gcctccacac gcccatgtac 180 ttcttcctgg ccaacctgtc ctttgtagac atctgcatca cctccaccac catcccgaag 240 atgctctgga acatccagac ccagagcaaa gtcataacct atgaggactg catcacccag 300 atgaactttt tcataatctt ttcaggattg gacatctgcc tcctggccat tatggcctat 360 gacaggtttg tggccatctg tcaccccctg caatacacgg tcatcatgag cccccggctc 420 tgtgcactgc tggtcctggt gtcctggatc acgagtgtcc tgcattcctt gttgcaaact 480 tcaatggtgt tgcggctgtc cttctgtaca gtcgtggaaa tcccccattt ttcctgtgaa 540 ctcaatcaga tgacccaagt tgcctgttct gacacctttc ttaataactt ggtgatgtat 600 tttgcagcta tcctagtggg tggcggtcct ttctttggga tcctttactc ttactccaag 660 atagtttcct ccatacgtgg gatctcatca gctcagggca agtataaagc attttccacc 720 tgtgcatctc acctctcggt tgtctcctta ttttattgta cgggcctcgg agtgtacctt 780 agctctgctg ctacccagag ctcccactca agtgccacag cctcggtgat gtacacggtg 840 gtcacgccca tgctgaatcc cttcatctac agcctgagga acaaagacat aaagaaggct 900 ctgaggagat tctctgcgat ggcagttaga aaaggtccaa ttgtcctgtg gttgaagaa 959

<210> 2386 <211> 320 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (320)..(320) <223> Any amino acid

Page 2643

069269_0225_SL.TXT

<400> 2386 Asn Asp Thr Arg Thr Ser Glu Phe Leu Leu Leu 15 Gly Met 1 Glu Pro Gly 5 10 Phe Ser Asp Ser Pro Glu Gln Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Tyr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Ile Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Asp 85 90 95 Cys Ile Thr Gln Met Asn Phe Phe Ile Ile Phe Ser Gly Leu Asp Ile 100 105 110 Cys Leu Leu Ala Ile Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Gln Tyr Thr Val Ile Met Ser Pro Arg Leu Cys Ala Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Thr Ser Val Leu His Ser Leu Leu Gln Thr 145 150 155 160 Ser Met Val Leu Arg Leu Ser Phe Cys Thr Val Val Glu Ile Pro His 165 170 175 Phe Ser Cys Glu Leu Asn Gln Met Thr Gln Val Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Leu Val Met Tyr Phe Ala Ala Ile Leu Val Gly Gly 195 200 205

Page 2644

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Gly Pro Phe Phe Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Lys Ala Leu Arg Arg Phe 290 295 300 Ser Ala Met Ala Val Arg Lys Gly Pro Ile Val Leu Trp Leu Lys Xaa 305 310 315 320

<210> 2387 <211> 933 <212> DNA <213> Felis catus <400> 2387

ttacatcact tgaacgcaaa aaattctttt cagagcactc tttatgtctt tgttcctcag 60 gctgtagatg aaggggttca gcatgggcgt gaccaccgtg tacatcactg aggctgtagc 120 acttgactgt gagctctggg tagcagcaga gctcaggtac acgccgagca tcgtacagta 180 aaataaacac acgaccgaca ggtgagacgc acaggtggaa aatgttttat acttgccctt 240 agctgatgca atcccacgta tagaggacac tatcttggaa taagagtaaa ggatcccagc 300 aaaaggacca ccacccagca ggacagctgc aagatacatc accacgttat taagaaaggt 360 gtcagaacag gcaagctgga gcatctcatt gagttcacaa aaaaagtggg ggatgtgcaa 420 gtgtgtacag aaggacagcc gcaacatcat taaactttgt aacagggaat tcaggacaca 480

Page 2645

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catgatccag gacacaagaa ccagcagccc acagagccgg gggttcatga tgaccgtgta 540 gtgcaggggg tgacagatgg ccacaaaccg gtcataggcc atcacactca ggaggaagac 600 gtccagtaca gcaaagagaa tgagaaaata aatctgtgtg atgcagtcct cataagttat 660 gactttgctc tgagtctgga tgttcaccag catctttgga atcgtggtgg aggtgaagca 720 aatatctacg aaggacaggt tggcgaggaa gaagtacatg ggagtgtgga ggttggggtc 780 tgtgctgatg gccaaaatta tgagcaggtt gccaaacaca gtgatcaggt acatggagag 840 gaaaagccca aatatgaggg gctgcagttc tggtctctct gaaaatccca gaagaagaaa 900 ttctgaaatt cgtgttttgt tgctcagttc cat 933

<210> 2388 <211> 310 <212> PRT <213> Felis catus

<400> 2388 Lys Thr Arg Ile Ser Glu Phe Leu Leu Leu Gly Met Glu 1 Leu Ser Asn 5 10 15 Phe Ser Glu Arg Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Thr Asp Pro Asn Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Asp 85 90 95 Cys Ile Thr Gln Ile Tyr Phe Leu Ile Leu Phe Ala Val Leu Asp Val 100 105 110

Phe Leu

Leu

Ser Val Met Ala

Tyr Asp Arg Phe Val Ala Page 2646

Ile Cys

His

069269_0225_SL.TXT

115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Met Cys Val Leu Asn Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Met Leu Arg Leu Ser Phe Cys Thr His Leu His Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Glu Met Leu Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Val Val Met Tyr Leu Ala Ala Val Leu Leu Gly Gly 195 200 205 Gly Pro Phe Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ala Ser Ala Lys Gly Lys Tyr Lys Thr Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Cys Leu Phe Tyr Cys Thr Met Leu

245 250 255

Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser Gln Ser Ser Ala 260 265 270

Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285

Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Ser Ala Leu Lys Arg Ile

290 295 300 Phe Cys Val Gln Val Met 305 310 <210> 2389

Page 2647

069269_0225_SL.TXT gtctccagcc gccctcttta accgtgtaca aggtacactc gtggaaaatg ttagaataag tccatcacca tcacaaaaaa ctttgcaaca agccgggggt taggccatca tgtgtgatgc ttcgggacag tacatggggg aacacagtga tcctctgaaa ccaggactat tgtctctgtt tcaccgaggc ctaggcttgt ctttatactt agtaaaggat cgtcattaag agtgggggac aggaattcag tcatgatgac cggtcaagag agcctgcata tggtggagat tgtggaggtg tcaggtacat atcccagaag <211> 969 <212> DNA <213> Felis catus <400> 2389 tcatgggtat tctcttcaga gggcgtgacc agcagagctg agacgcacag ggaaactatc agctgcaaga ctcattgagt catcattaaa cagcccacag gaagcggtca aaaatacatc ccagagcatc caggaagaag caggttccca taatgccggt tggttccat <210> 2390 <211> 310 <212> PRT <213> Felis catus <400> 2390

Met Glu Pro Gly Asn Asp Thr Gln Ile 1 5

tggcccttac attgctggaa ccccaatgat 60 cctcaggctg tagatgaagg ggttcagcat 120 tgtgacactt gagagtgagc tctgggtagc 180 acaaaaaaat aaggagacaa cggagaggtg 240 gccctgagct gatgagatcc tacgtatgga 300 cccagccagg ggagcaccac ccagcagcac 360 aaaggtgtca gaacaggcaa gctggagcat 420 atgcaagtgt gtacagaagg acagccacaa 480 gacacacatg acccaggaca ccagaacaag 540 cgtgtagtgt agggggtgac agatggccac 600 aaagacttct aatcctgcaa agtgtatgaa 660 ggttatgact ttgctctgag tccggatgtt 720 gaagcagatg tccgaaaagg acaggttggc 780 ggagtcagag ctgacggcca ggaggatgag 840 ggagaggaaa agcccaaata tgaggggctg 900 aaaaaattct gaaatttgtg tatcatttcc 960

969

Phe Ser Glu Glu Pro Ala Leu Gln Pro 20 25

Ser Glu Phe Phe Leu Leu Gly 10 15 Leu Ile Phe Gly Leu Phe Leu 30

Page 2648

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Ser Met Tyr 35 Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Leu Leu Ala 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Ser Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Arg Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Ile His Phe Ala Gly Leu Glu Val 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Val Met Cys Val Leu Asn Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Met Leu Trp Leu Ser Phe Cys Thr His Leu His Val Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Glu Met Leu Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asp Val Val Met Asp Leu Ala Ala Val Leu Leu Gly Gly 195 200 205 Ala Pro Leu Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Arg Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240

Page 2649

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Cys Ala Ser

Gly Val Tyr

Thr Ala Ser 275

Ile Tyr Ser 290

Ile Gly Val 305 <210> 2391 <211> 914 <212> DNA <213> Felis <400> 2391 ttttttcttt ctctccatgt gactcccacc tgcttcacct ataacctatg aactacatcc actacacggg tgagtgtcct actcactttt atgacacagt tttactctta ataaagcatt catus ggggattttc acctgatcac tccacacccc ccaccaccat aggacttcat tgaccgtgat catcatgaac gcattcctta tctgtcattt gatgtatttt ttctaagatt ttccacctgt

His Leu 245 Ser Val Val Leu 260 Ser Ser Ala Ala Val Met Tyr Thr Val 280 Leu Arg Asn Arg 295 Asp Pro Ala Met 310

Ser Leu Phe 250 Thr Gln Ser 265 Val Thr Pro Ile Lys Arg

Phe Cys Thr

Ser Leu Ser 270

Met Leu Asn 285

Ala Leu Lys 300 agaggaacca tgtgtttggc catgtacttc cccgaagatg cacccagatg ggcctatgac ccccggctct tcaccaagtt aatcagatga ttaaccgtgt atttcctcca gcgtctcacc gaactgcagc aacctgctca ttcctggcca ctctggaaca tattttttcc cgatttttgg gtgggctgct taatggtgct tccaacctgc tggtggctgg tacatagaat tcttggttgt ccctcatatt tcctcctggc acctgtcctt tccagaccca tactcttcac ccatctgtca ggctctggtg gcagctgtac ctgctctgac tggtcccctt cccatcagct ctccttactt

Ser Leu 255

Ser Val

Pro Phe

Arg Ile tgggcttttc cgtcagctct tgtagacatc gagtaacgtc gggactggac ccccctctgc tcctggatca ttctgcacac acctttctta gctgggatcc cagggtaagt tattgtgcgg

120

180

240

300

360

420

480

540

600

660

720

Page 2650

069269_0225_SL.TXT tcctcggagt atactttagc tctgctgcta cccagagttc acgctcaagt gcaacagcct cagtgatcat gcctatgctg aaccctgtca tctacagcat gaggaacaaa gacataaagg aggctctgat gagatccttc gggacggcag gtgtaaaagg gaccattgtc ctgctagtga agaagtgccc ttga

780

840

900

914 <210> 2392 <211> 179 <212> PRT <213> Felis catus <400> 2392

Met Asn Pro Arg Leu Cys Gly Leu Leu Ala Leu Val Ser Trp Ile Met 1 5 10 15 Ser Val Leu His Ser Leu Ser Pro Ser Leu Met Val Leu Gln Leu Tyr 20 25 30 Phe Cys Thr His Ser Leu Phe Leu Ser Phe Asn Gln Met Ile Gln Pro 35 40 45 Ala Cys Ser Asp Thr Phe Leu Asn Asp Thr Val Met Tyr Phe Leu Thr 50 55 60 Val Leu Val Ala Gly Gly Pro Leu Ala Gly Ile Leu Tyr Ser Tyr Ser 65 70 75 80 Lys Ile Ile Ser Ser Ile His Arg Ile Pro Ser Ala Gln Gly Lys Tyr 85 90 95 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Leu Val Val Ser Leu Leu 100 105 110 Tyr Cys Ala Val Leu Gly Val Tyr Phe Ser Ser Ala Ala Thr Gln Ser 115 120 125 Ser Arg Ser Ser Ala Thr Ala Ser Val Ile Met Pro Met Leu Asn Pro 130 135 140 Val Ile Tyr Ser Met Arg Asn Lys Asp Ile Lys Glu Ala Leu Met Arg

Page 2651

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145 150 155 160

Ser Phe Gly Thr Ala Gly Val Lys Gly Thr Ile Val Leu Leu Val Lys 165 170 175

Lys Cys Pro <210> 2393 <211> 968 <212> DNA <213> Felis catus <400> 2393

atggacccag gaaatgatac cggaatttca gaatttcttc ttatgggatt ttcagaagaa 60 ccagaactgc agcccctcat atttgggctt ttcctctcca tgtacctgat cactgtgttt 120 ggcaacctgc tcatcctcct ggccgtcagc tctgactccc acctccacac gcccatgtac 180 ttcttcctgg ccaacctgtc ctttgtagac atctgcttca cctccaccac catcccgaag 240 atgctctgga acatccagac ccagagcaaa gtcataacct atgcaggctg catcacacag 300 atatactttt tcataacctt tgcagggatg gatgactttc tcctgagtgt gatggcctac 360 gacaggtttg tggccatctg ccaccccctg caatacacgg tcatcatgaa cccccggctc 420 tgtggactcc tggttctggt gtcctggatc atgagtgttc tgtattcctt gttacaaacc 480 ttaatggtgt tgcggctatc cttctgtaca gaggtggaaa tcccccactt tttctgtgaa 540 ctcaatcaga tgatccaact tgcctgtcga gacacctttc ccaataacat ggtgttgtat 600 tttggagcta tgttgctggc tggtggtccc ttcattggaa tactttactc ttactctaaa 660 atagtttcct ccatatgtgg aatctcatca gctcgaggca aatacaaagc attttccacc 720 tgcgcgtctc acctctcggt tgtctcctta ttttattgca caagcctagg agtgtacctc 780 agctctgctg ctacccagag ctcacactca agtgccacag cctcggtgat atacacggtg 840 gtcacgccca tgctgaaccc cttcatctac agcctgagga acagagacat aaaggaggct 900 ctgatgagat tctctgggat ggtagctaca aaagggacaa ttgtcctggg ctgaagaagt 960

tcccgtga 968

Page 2652

069269_0225_SL.TXT <210> 2394 <211> 317 <212> PRT <213> Felis catus

<400> 2394 Leu Leu Met 15 Gly Met 1 Asp Pro Gly Asn Asp Thr Gly 5 Ile Ser 10 Glu Phe Phe Ser Glu Glu Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Ile Tyr Phe Phe Ile Thr Phe Ala Gly Met Asp Asp 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Gln Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Met Ser Val Leu Tyr Ser Leu Leu Gln Thr 145 150 155 160 Leu Met Val Leu Arg Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Arg Asp Thr 180 185 190

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Phe Pro Asn 195 Asn Met Val Leu Tyr Phe Gly 200 Ala Met Leu Leu Ala Gly 205 Gly Pro Phe Ile Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Cys Gly Ile Ser Ser Ala Arg Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Thr Ala Ser Val Ile Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Glu Ala Leu Met Arg Phe 290 295 300 Ser Gly Met Val Ala Thr Lys Gly Thr Ile Val Leu Gly 305 310 315

<210> 2395 <211> 934 <212> DNA <213> Felis catus <400> 2395 ggaaaatggc ccttttatgg cttccctctg aaaaatacat ttagagcctc ctttctgtct ctgttcctca ggctgtagat gaaggggttc agcatgggca tgaccactgt gtacatcact taggatattg cacttgagtg ggagctctgg gtagcagcag agctgaggta cactcccagg ccagcacaat aaaatagaga gacaacggag aggtgagacg cacaggtgga aaatgcctta tacttgccca gagctgatga gatcccacgt atggaggaaa ctatcttaga ataagagtac aggaccccag ccaggggagc accacccaac agcacagctg caagatatat caccgtgtca

120

180

240

300

360

Page 2654

069269_0225_SL.TXT

tgaagaaagg tgtcagagca ggcaagttgg atcatctgat tgagctcaca gaaaaagcgg 420 gggatttgca tgcctgtcca gaaggacagc tgcaacacca ttaaggtttg tatcaaggaa 480 tgcaggatgt tcatgatcca ggacaacaga accagcagcc cacagagccg ggggttcatg 540 gtgactgggt agtgtagcgg gtgacagatg accacaaagc tgtcataagt cgtcagtcag 600 gaggaagttg tctaaaccta caaagagtat gaaaaagtac atctgcatga cacagctttc 660 ataagttatg acttttacga cttttctgtg tttgtacatt cccatctggg ggaccgtggt 720 gaaggagaca tagatgttta cgaaggacag gtggtcgagg aagaagtacg tgggtgtgtg 780 gaggtgggag tcagacttta cagccaggat gatgagcaaa ttcccaagta tggtgaccag 840 gtacatggac aggaacagcc caaagaggaa gggttgcaat tctggttcct ccgaagatcc 900 cagaagaaga aattttgaac ttcgtgtatc attg 934

<210> 2396 <211> 116 <212> PRT <213> Felis catus <400> 2396

Asn Asp Thr Arg Ser Ser Lys Phe Leu Leu Leu Gly Ser Ser Glu Glu 1 5 10 15 Pro Glu Leu Gln Pro Phe Leu Phe Gly Leu Phe Leu Ser Met Tyr Leu 20 25 30 Val Thr Ile Leu Gly Asn Leu Leu Ile Ile Leu Ala Val Lys Ser Asp 35 40 45 Ser His Leu His Thr Pro Thr Tyr Phe Phe Leu Asp His Leu Ser Phe 50 55 60 Val Asn Ile Tyr Val Ser Phe Thr Thr Val Pro Gln Met Gly Met Tyr 65 70 75 80 Lys His Arg Lys Val Val Lys Val Ile Thr Tyr Glu Ser Cys Val Met 85 90 95 Gln Met Tyr Phe Phe Ile Leu Phe Val Gly Leu Asp Asn Phe Leu Leu Page 265! 5

100

069269_0225_SL.TXT 105 110

Thr Asp Asp Leu 115 <210> 2397 <211> 963 <212> DNA <213> Felis catus <400> 2397

tcatgggcac atcttcagcc ccaggacaat tggcccttac gtccctggaa ccccaacgat 60 tcttttcaga gccctcttta tgtctctatt cctcaggctg tagatgaagg ggttcagcat 120 gggtgtgacc accgtgtaca tcaccgaggc tgtggcactt gaccgtgagc tctgggtggc 180 agcagagccg aggtacactc ctaggactat acagtaaaat agggagacaa ccgagaggtg 240 agatgcacag gtggaaaatg ctttatactt gccctgagct gatgagatcc cacgtatgga 300 ggaaactatc ttagaataag agtaaaggat ccctgctagg gaagcaccac ccaacaatcc 360 agctgcaaaa tgcatcacca tgtcattaag aaaggtgtca gaacaggcaa gttggaccac 420 ttgattgatt tcacaaaaaa agtgggggat ttctacttgt gtgcagaagg acagccacaa 480 catcattaag gtttgtaata acgaattcag ggtgctcacc gtccaggaca ccagaacaag 540 cagtccacag aagatgggtt tcatgatgat cgtgtagtgc aaagggtgac agatggccac 600 aaatcggtca taagccatca cagccagtag aaagttgtcc aatccagcaa agagtaggaa 660 aaagtacatc tgtgtgatgc agcctgcata agttatgact tttctctgag tctggatgtt 720 caccagcatc tttgggacag tagtggaggt gaagcagatg tctacaaagg ataggttggc 780 caggaagaag tacatggggg tgtggagatg ggagtcagag ctgacggcca ggatgatgag 840 caggttccca aacacagtga tcaggtacat ggagaggaaa aggccaaata tgaggggctg 900 cagttctgga ccctctgaaa atcccagaag aaaaaattct gaaatttgtg tatcatttcc 960

tgg 963 <210> 2398 <211> 308 <212> PRT <213> Felis catus

Page 2656

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<400> 2398 Thr Gln Ile Ser Glu Phe Phe Leu Leu Gly Phe 15 Ser Pro 1 Gly Asn Asp 5 10 Glu Gly Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu Ser Met 20 25 30 Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala Val Ser 35 40 45 Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu 50 55 60 Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys Met Leu 65 70 75 80 Val Asn Ile Gln Thr Gln Arg Lys Val Ile Thr Tyr Ala Gly Cys Ile 85 90 95 Thr Gln Met Tyr Phe Phe Leu Leu Phe Ala Gly Leu Asp Asn Phe Leu 100 105 110 Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu 115 120 125 His Tyr Thr Ile Ile Met Lys Pro Ile Phe Cys Gly Leu Leu Val Leu 130 135 140 Val Ser Trp Thr Val Ser Thr Leu Asn Ser Leu Leu Gln Thr Leu Met 145 150 155 160 Met Leu Trp Leu Ser Phe Cys Thr Gln Val Glu Ile Pro His Phe Phe 165 170 175 Cys Glu Ile Asn Gln Val Val Gln Leu Ala Cys Ser Asp Thr Phe Leu 180 185 190 Asn Asp Met Val Met His Phe Ala Ala Gly Leu Leu Gly Gly Ala Ser 195 200 205

Page 2657

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Leu Ala 210 Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser Ile Arg 215 220 Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Ile Val Leu Gly Val 245 250 255 Tyr Leu Gly Ser Ala Ala Thr Gln Ser Ser Arg Ser Ser Ala Thr Ala 260 265 270 Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Lys Arg Ile Val Gly 290 295 300

Val Pro Gly Thr 305 <210> 2399 <211> 942 <212> DNA <213> Felis catus <400> 2399

cccactgctg agaggcacca ccctgctgag gaatctcctt agagccccct tcatgtccct 60 attcctcaga ctgtagatga aggggttcag catgggcgtg acaattgtgt acatcactga 120 ggccaccaga cttgtcctag aggatgaagt cactgcagaa ctgaggtaga ccccaagacc 180 tgtgccatag aacaaggaga ccaccgagag gtgagaccca cacgtggaaa aggctttgta 240 cttgccagta gctgaggaaa tgttgagtat ggaggaaaca atatgaaagt aggacaaaag 300 tattccgttg aaaggaatca cggccagaag gccagttgca gaatacacca ccatggtatt 360 gacgaaggtg tcagaacagg caagcttcag gacttcggga agatcacaaa agaagtgtgg 420 gatttccatg tttgtgcaga aggacagcct caaaagggtc aaggtctcga gcagggaacc 480

Page 2658

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catgatactg aggcaccagg atcccaatgc caacagccca cagaactggc cgttcatgat 540 gattgagtag tgcagggggt gacagatggc cacaaagcgg tcataggcca tcgcggtcag 600 gagtaagttg tccaggcatc caaacacaat gaaaaaaaaa atctggctga ggcagccttt 660 atatgttatg attgtgctct gagtctggat gttccagagc atcttcggga cagtagtgga 720 ggtaaaacag atgtcagcca aggacaggtt ggaaaggaag aagtacatgg gggtgtggag 780 gagggagtca gagcagatgg ccaggatgat gagcagattc ccagtgaccg tgaccaagta 840 catggacagg aacagcccaa agagcacaaa ttgaatatct gactttgctg aaaatcccaa 900 gaggagaaat tccgaagcac gcgtttgatt tcctgattcc at 942

<210> 2400 <211> 314 <212> PRT <213> Felis catus <400> 2400

Met Glu Ser Gly Asn Gln Thr Arg Ala Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Ala Lys Ser Asp Ile Gln Phe Val Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Val Thr Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Cys Ser Asp Ser Leu Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Leu Ala Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Thr Ile Ile Thr Tyr Lys Gly 85 90 95 Cys Leu Ser Gln Ile Phe Phe Phe Ile Val Phe Gly Cys Leu Asp Asn 100 105 110 Leu Leu Leu Thr Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Page 265 9

069269_0225_SL.TXT

115 120 125 Pro Leu His Tyr Ser Ile Ile Met Asn Gly Gln Phe Cys Gly Leu Leu 130 135 140 Ala Leu Gly Ser Trp Cys Leu Ser Ile Met Gly Ser Leu Leu Glu Thr 145 150 155 160 Leu Thr Leu Leu Arg Leu Ser Phe Cys Thr Asn Met Glu Ile Pro His 165 170 175 Phe Phe Cys Asp Leu Pro Glu Val Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 Phe Val Asn Thr Met Val Val Tyr Ser Ala Thr Gly Leu Leu Ala Val 195 200 205 Ile Pro Phe Asn Gly Ile Leu Leu Ser Tyr Phe His Ile Val Ser Ser 210 215 220 Ile Leu Asn Ile Ser Ser Ala Thr Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Val Thr Ser Ser Ser Arg Thr Ser Leu 260 265 270 Val Ala Ser Val Met Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Arg Arg Phe 290 295 300 Leu Ser Arg Val Val Pro Leu Ser Ser Gly

305 310 <210> 2401

Page 2660

069269_0225_SL.TXT <211> 969 <212> DNA <213> Felis catus <400> 2401 atggaactaa gcaatgatac acaaatttca gagtttcttc ttctgggatt ttcagaggaa 60 ccagaactgc agcccctcat atttgggctt ttcctctcca tgtacctgat cactgtgttt 120 ggaaacctgc tcatcatcct ggccatcagg tctgactccc acctccacac ccccatgtac 180 ttcttcctgg ccaacctgtc ctttgtagac ttctgcttca cctccaccac cgtcccgaag 240 atgcttctga acatccagac tcagagcaag gtcataacct atgcaggctg catcagccag 300 atgtattttt tcatactctg tgcagagttg gatgacctta tcctgtctgc aatggcctat 360 gaccgatttg tggccatctg tcaccccctg caatacacca tcatcatgag cccccagctc 420 tgtggattgc ttgttctggt atcctggatc atcagtgttc tgaactcact gttacaaacc 480 ttaatggtgc tgccactgtc cttctgcaca ggcatggaag tcccccattt tttttgtgaa 540 ctcaatcagg tcctcaggct tgcctgttct gagacctttc ttaatgacac ggtgatgtat 600 tttgcaactg tgctcctcgg tggtgctccc ttggctggga tcctttactc ttactctaag 660 atagtctcct ccatacgtgg gatctcatca gctcagggca agtataaggc attttccacc 720 tgtgcatctc acctctcagt tgtctcctta ttttgttgta caggcctcgg agtgtacctt 780 agctctgttg ctacccagag ttcccactca agtacaacag cctcggtgat gtacacggtg 840 gtcacgccca tgctgaaccc tttcatctac agcctgagga acagagacat aaagagggct 900 ctgaaaagaa tcgttgggat tccagtgatg taaggaccaa tcttcctggg gctacagatg 960 tgcccatga 969 <210> 2402 <211> 310 <212> PRT <213> Felis catus <400> 2402

Met Glu Leu Ser Asn Asp Thr Gln Ile Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Glu Glu Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu

20 25 30

Page 2661

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Ser Met Tyr 35 Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 40 45 Ile Arg Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Phe Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Ser Gln Met Tyr Phe Phe Ile Leu Cys Ala Glu Leu Asp Asp 100 105 110 Leu Ile Leu Ser Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Gln Tyr Thr Ile Ile Met Ser Pro Gln Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Ile Ser Val Leu Asn Ser Leu Leu Gln Thr 145 150 155 160 Leu Met Val Leu Pro Leu Ser Phe Cys Thr Gly Met Glu Val Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Val Leu Arg Leu Ala Cys Ser Glu Thr 180 185 190 Phe Leu Asn Asp Thr Val Met Tyr Phe Ala Thr Val Leu Leu Gly Gly 195 200 205 Ala Pro Leu Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240

Page 2662

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Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Cys Cys Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Val Ala Thr Gln Ser Ser His Ser Ser Thr 260 265 270 Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Lys Arg Ile 290 295 300 Val Gly Ile Pro Val Met

305 310 <210> 2403 <211> 967 <212> DNA <213> Felis catus <400> 2403 ggaccaagca atgataccca aatttcagat ttttttcttc tgggattatc aaatgaacca 60 gaattacagc ccctcatatt tgggcttttc ttctccatgt acttgatcag tgtctttgga 120 aacctgctca tcatcctggc tgtcagctct gcctcccacc tccacacgcc catgtatttc 180 tttctctcca tcctgtcctt tgtggacatt tgtatcactt ctaccatcat cccaaagatg 240 ttggtaaata tacagacaca gactaaaatt ataacctata caggatgcat cagccagatc 300 tatttttcca cactctttgc aggctgggac aactttctcc tggccgtgat ggcctatgac 360 cgcttcgtgg ccatctgtca acccctgcac tacacggtca tcatgaaccc ccggcctctg 420 tggactgctg gctctggtgt cctggatcac gagtgtcctt aattccttgt tacaaagctt 480 aatggtgctg cgattgtcct tctgtacaaa ctcagaaatc cctcactttt tctgtgaact 540 caatcagatg acccagcttg cctgttctga tacctttctg aacgacacag tgatgcatat 600 ttcaactgtg ttgctggccg gtggtcccct tgctgggatc ctttactctt actctaagat 660 tatttcctct ctacgtagaa tcccatcagc tcagggcaag tataaagcat tttccacctg 720

Page 2663

069269_0225_SL.TXT tgcgtctcac ctctcagttg tctccttatt ttattgcacg gtcctggaag ggtaccttat ctcctctgct acccagaact cccactcaag tgcaacagcc tcggtgatgt acatggtggt cacgcccatg ctgaacccct tcatctacag cctgaggaac aaagacataa agggggctct gaggagattc tttgggatgg cagggacaaa agggaccatc gtcctgctgg tgaagaagtg cccttga

780

840

900

960

967 <210> 2404 <211> 161 <212> PRT <213> Felis catus <400> 2404

Met Val Leu Arg 1 Leu 5 Ser Phe Cys Thr Asn Ser Glu Ile Pro His Phe 10 15 Phe Cys Glu Leu Asn Gln Met Thr Gln Leu Ala Cys Ser Asp Thr Phe 20 25 30 Leu Asn Asp Thr Val Met His Ile Ser Thr Val Leu Leu Ala Gly Gly 35 40 45 Pro Leu Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Ile Ser Ser Leu 50 55 60 Arg Arg Ile Pro Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr Cys 65 70 75 80 Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Val Leu Glu 85 90 95 Gly Tyr Leu Ile Ser Ser Ala Thr Gln Asn Ser His Ser Ser Ala Thr 100 105 110 Ala Ser Val Met Tyr Met Val Val Thr Pro Met Leu Asn Pro Phe Ile 115 120 125 Tyr Ser Leu Arg Asn Lys Asp Ile Lys Gly Ala Leu Arg Arg Phe Phe 130 135 140

Page 2664

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Gly Met Ala Gly Thr Lys Gly Thr Ile Val Leu Leu Val Lys Lys Cys 145 150 155 160

Pro <210> 2405 <211> 933 <212> DNA <213> Felis catus <400> 2405 atggacccag gaaatgatac aggaacttca caatttcttc ttatgggatt ttcagaagaa 60 ccaggactgc agcccctcat atttggcctt ttcctctcca tgtacctgat cactgtgttt 120 gggaacctgc tcatcatcct ggccgtcagc tctgactccc gcctccacac acccatgtac 180 ttcttcctgg ccaacctgtc ctttgtagac atctgcttca cctccaccac catcccaaag 240 atgctggtga acatccagac tgagaacaaa gtcataacct atgaggactg catcacacag 300 atttattttt tcatactctt tgctgtgatg gacgtcttcc tcctgagtgt gatggcctat 360 gacaggtttg tggccatctg ccaccccctc cactacacga tcatcatgaa cccccagctt 420 tgtgggctgt tggttctggt gtcctggatc atgtgtgtcc tgaattcctt gttacagagt 480 ttaatgatgt tgcggctgtc gttctgtacc caggtagaaa ttccccactt tttctgtgaa 540 ctcaatgaga tgctccagct tgcctgttct gacacctttc ttaataacgt ggtgatgtat 600 cttgcagctg tcctgctggg tggtggtcct tttgccggga tcctttactc ttattccaag 660 atagtttcct ctatacgtgg gattgcatca gctaagggca agttcaaaac gttttccacc 720 tgtgcatctc acctgtcggt tgtgtgttta ttttactgta cgatgcttgg cgtgtacctt 780 agctctgctg ctacccagag ctcccactca agtgccacag cctcggtgat gtacacggtg 840 gtcacgccca tgctgaaccc cttcatctac agcctgagga acagagacat aaagagtgct 900 ctgaaaagaa ttgttggggt tcaagtgatg taa 933 <210> 2406 <211> 310 <212> PRT <213> Felis catus

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<400> 2406 Asn Asp Thr Gly Thr Ser Gln Phe Leu Leu Met 15 Gly Met 1 Asp Pro Gly 5 10 Phe Ser Glu Glu Pro Gly Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr Glu Asn Lys Val Ile Thr Tyr Glu Asp 85 90 95 Cys Ile Thr Gln Ile Tyr Phe Phe Ile Leu Phe Ala Val Met Asp Val 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Ile Ile Met Asn Pro Gln Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Met Cys Val Leu Asn Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Met Leu Arg Leu Ser Phe Cys Thr Gln Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Glu Met Leu Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Val Val Met Tyr Leu Ala Ala Val Leu Leu Gly Gly 195 200 205

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Gly Pro Phe Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ala Ser Ala Lys Gly Lys Phe Lys Thr Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Cys Leu Phe Tyr Cys Thr Met Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Ser Ala Leu Lys Arg Ile 290 295 300 Val Gly Val Gln Val Met

305 310 <210> 2407 <211> 950 <212> DNA <213> Felis catus <400> 2407

acacaaattt cagaattttt tcttctggga ctttcagagg aaccagcatt ccagcccctc 60 atatttgggc ttttcctctc catgtatctg atcactgtgt ttgggaacct gctcatcatc 120 ctggccgtca gctctgactc ccacctccac acgcccatgt acttcttcct ggccaacctg 180 tcctttgtag acatttgctt cacctccacc accgtcccaa agatgctctg gaacatccag 240 acccagagca aagtcataac ctatgaggac tgcatcgcac agatgaactt cttcatactc 300 ttttcagtgt tggatgactt tctcctgagt gtgatggcct atgaccggtt tgtggccatc 360 tgtcaccccc tgcactacac aatcatcatg aacccccagc tctgtggact cctggttctg 420 gtgtcctgga tcatgagtgt tctgtattcc ttgttacaaa ccttaatggt gttgcggctg 480

Page 2667

069269_0225_SL.TXT tccttctgta cagaggtgga aatcccccac tttttctgtg aactcaatca gatgatccaa cttgcctgtt ctgacacctt tcttaatgac atgatgatgt attttgcaac tgtgctgctg ggtggtgctc ccctggctgg ggtcctttac tcttattcta agatagtttc ctccatacgt agcatctcat cagctctggg caagtataag gcattttcca tctgtgcatc tcacctctcg gttgtctctc tattttattg tactggcctg ggagtgtacc tcagctctgc tgctacccag agctcacact caagtgccac agcctcggtg atgtacacag tggtcacgcc catgctgaac cccttcatct acagcctgag gaacagagac ataaagggcg ctctgaggag attctctgca atggcagcta taaaagggct aactgtcttg ggctgaagaa tttcccatga

540

600

660

720

780

840

900

950 <210> 2408 <211> 311 <212> PRT <213> Felis catus

<400> 2408 Thr Gln Ile Ser Glu Phe Phe Leu 1 5 Phe Gln Pro Leu 20 Ile Phe Gly Leu Val Phe Gly 35 Asn Leu Leu Ile Ile 40 Leu His 50 Thr Pro Met Tyr Phe 55 Phe Ile 65 Cys Phe Thr Ser Thr 70 Thr Val Thr Gln Ser Lys Val 85 Ile Thr Tyr Phe Phe Ile Leu 100 Phe Ser Val Leu Ala Tyr Asp Arg Phe Val Ala Ile

Leu Gly 10 Leu Ser Glu Glu Pro 15 Ala Phe 25 Leu Ser Met Tyr Leu 30 Ile Thr Leu Ala Val Ser Ser 45 Asp Ser His Leu Ala Asn Leu 60 Ser Phe Val Asp Pro Lys Met 75 Leu Trp Asn Ile Gln 80 Glu Asp 90 Cys Ile Ala Gln Met 95 Asn Asp 105 Asp Phe Leu Leu Ser 110 Val Met Cys His Pro Leu His Tyr Thr Ile

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115 120 125 Ile Met Asn Pro Gln Leu Cys Gly Leu Leu Val Leu Val Ser Trp Ile 130 135 140 Met Ser Val Leu Tyr Ser Leu Leu Gln Thr Leu Met Val Leu Arg Leu 145 150 155 160 Ser Phe Cys Thr Glu Val Glu Ile Pro His Phe Phe Cys Glu Leu Asn 165 170 175 Gln Met Ile Gln Leu Ala Cys Ser Asp Thr Phe Leu Asn Asp Met Met 180 185 190 Met Tyr Phe Ala Thr Val Leu Leu Gly Gly Ala Pro Leu Ala Gly Val 195 200 205 Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser Ile Arg Ser Ile Ser Ser 210 215 220 Ala Leu Gly Lys Tyr Lys Ala Phe Ser Ile Cys Ala Ser His Leu Ser 225 230 235 240 Val Val Ser Leu Phe Tyr Cys Thr Gly Leu Gly Val Tyr Leu Ser Ser 245 250 255 Ala Ala Thr Gln Ser Ser His Ser Ser Ala Thr Ala Ser Val Met Tyr 260 265 270 Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn 275 280 285 Arg Asp Ile Lys Gly Ala Leu Arg Arg Phe Ser Ala Met Ala Ala Ile 290 295 300 Lys Gly Leu Thr Val Leu Gly

305 310 <210> 2409

Page 2669

069269_0225_SL.TXT <211> 906 <212> DNA <213> Felis catus <400> 2409 atggcaccag gcaatgatac ccaaatttca gaatttcttc ttctgggatt atcagatgaa 60 ccagaattac agcccctcat atttgggctt ttcctctcca tgtacctgat cgttgtgttt 120 ggaaacctgc tcattgtcct agctgtcagc tctgactccc acctccacac acccatgtac 180 ttcttcctgg ccaacctgtc ctttgtggac atctgcttca cctctactgt catcccaaag 240 atgctctgga acatccagac tcagagcaaa gtcataacct atgcaggctg catcacacag 300 atgtactttt tcctactctt tgtagaatta gacatctttc tcctgactgt gatggcttac 360 gaccgctttg tggccatctg tcaccccctg aactacatgg tcatcatgaa cccccggctc 420 tgtggagtgc ttgttctggt gtcctggatt atgtgtgccc tgaattcctt gttagaaagc 480 ttaatggtat tgcggctgtc cttctgtaca gtcttggaaa tcccccactt tttctgtgaa 540 ctcaatcaga tgatccaact tgcctgttct gacacttttc tcaacaacat ggtgatgtat 600 tctggaatta tgctgctggc tggtggtccc tttgttggga tactttactc gtactctaag 660 atagtttcct ccatacgtgg gatctcatca tctcagggca agtataaagc attttccacc 720 tgtgcgtctc acctctcggt tgtctctcta ttttattgta ctggcctggg agtgtacctc 780 agctctgctg ctacccagag ctcccactca agtgccacag cctcagtggt gtatacagtg 840 gtcataccca tgctgaaccc cttcatctac agcctgagga acaaagacat gaagggggct 900 ctgatg 906 <210> 2410 <211> 302 <212> PRT <213> Felis catus <400> 2410

Met Ala Pro Gly Asn Asp Thr Gln Ile Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Ser Asp Glu Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30

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Ser Met Tyr 35 Leu Ile Val Val 069269_0225_SL.TXT Phe Gly Asn Leu Leu Ile 40 45 Val Leu Ala Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Val Ile Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Leu Leu Phe Val Glu Leu Asp Ile 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Asn Tyr Met Val Ile Met Asn Pro Arg Leu Cys Gly Val Leu 130 135 140 Val Leu Val Ser Trp Ile Met Cys Ala Leu Asn Ser Leu Leu Glu Ser 145 150 155 160 Leu Met Val Leu Arg Leu Ser Phe Cys Thr Val Leu Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Met Val Met Tyr Ser Gly Ile Met Leu Leu Ala Gly 195 200 205 Gly Pro Phe Val Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ser Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240

Page 2671

Cys Ala Ser His Leu 245 Ser Val 069269_0225_SL.TXT Val Ser Leu Phe Tyr Cys 250 Thr Gly 255 Leu Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Thr Ala Ser Val Val Tyr Thr Val Val Ile Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Met 290 295 300

<210> 2411 <211> 967 <212> DNA <213> Felis catus <400> 2411

atggacccag gaaacgatac aggaatttca gaatttcttc ttctgggatt ttcagaggaa 60 ccagaactgc agcccctcat atttgggctg ttcctctcca tgtacctgat cactgtgttt 120 gggaacctgc tcatcctcct ggccgtcagc tctgactccc acctccacac ccccatgtac 180 ttcttcctgg ccaacctgtc ctttgtagac atctgcttca cctccaccac cgtcccgaag 240 atgcttctga acatccagac ccacagcaag gtcataacct atgcaggctg catcacacag 300 atgtattttt tcacactctt tgcaggatta gacatctttc tcttgactat gatggcttat 360 gaccgctttg tggccatctg ttgtcccctg aactacatgg tcatcatgaa cccccggctc 420 tgtgggctgc tggttctggt gtcctggatc acgagtgtcc tgcattcctt gttacaaact 480 tcaatggtgt tgcaactgtc cttctgtaca gaggtggaaa tcccccactt tttctgtgaa 540 ctcaatcaga tgatccaatt tgcctgttct gacacctttc tcaataacat ggtgatgtat 600 tttggagcta tgctgctggg tggtggtccc ttcattggga tcctttactc gtactataag 660 atagtttcct ccatacgtgg gatctcatca gctcagggca agtataaagc attttccacc 720 tgtgcgtctc atctctcggt tgtctcctta tttttttgta cgagcctagg agtgtacctc 780 agctctgctg ctacccagag ctcccactca agtgccacag cctcagtgat gtacacggtg 840 gtcacaccca tgctgaaccc cttcatctac agcctgagga acagagacat aaaggaggct 900

Page 2672

960

967

069269_0225_SL.TXT ctgatgagat tctctgggat ggcagctaca aaagggccaa ttgtcctggg ctgaagaagt gacatga <210> 2412 <211> 317 <212> PRT <213> Felis catus <400> 2412

Met Asp Pro Gly Asn Asp Thr Gly Ile Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Glu Glu Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr His Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Thr Leu Phe Ala Gly Leu Asp Ile 100 105 110 Phe Leu Leu Thr Met Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Cys 115 120 125 Pro Leu Asn Tyr Met Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Thr Ser Val Leu His Ser Leu Leu Gln Thr 145 150 155 160 Ser Met Val Leu Gln Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His

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165 170 175

Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Phe Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Met Val Met Tyr Phe Gly Ala Met Leu Leu Gly Gly 195 200 205 Gly Pro Phe Ile Gly Ile Leu Tyr Ser Tyr Tyr Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Phe Cys Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Glu Ala Leu Met Arg Phe 290 295 300 Ser Gly Met Ala Ala Thr Lys Gly Pro Ile Val Leu Gly 305 310 315

<210> 2413 <211> 930 <212> DNA <213> Felis catus <400> 2413 ttatgacttc cctctgaaaa gtaaatttag agcctccttt atgtctctgt tcctcaggct gtagatgaag gggttcagca tgggcgtgac caccgcgtac atcaccgagg ctgtggcact tgagagtgag ctctgggtaa cagtagagct gaggtgcact cctaggctgg tacaataaaa taaggagaca accgagaggt gagatgtaca ggtggaaaat gccttatacc tgcccagagc

120

180

240

Page 2674

069269_0225_SL.TXT tgatgagatc ccacgtatgg gggagcacca cccaacagca agaacaggca agttggatca tgtacagaag gacagctgca gatccaggac accagagcca cagggggtga cagatggcca taaacctaca aagagtatga ttttctctgt gtgtgtatat gtctacaaag gacaggttgg gtttacagcc aggatgatga cagcccaaag aggaagggtt tgaatttcgt gtatcattgc <210> 2414 <211> 309 <212> PRT <213> Felis catus aggaaactat cttagaataa caactgcaaa atataccacc tctgattgac ttcacagaaa acaccattaa ggtttctaac gcagtccaca gagccggggg caaagcggtc ataagccatc aaaagtacat ctgcatgatg tcaccagcat cttcgggact caaggaagaa gtacatgggc gcagattccc aagtatggtg gcaactctgg ttcctctgaa ctagttccat gagtacagga tcccagccag aagttattaa gaaaggtgtc aagtggggga tatacacgtg aaggaatgca ggatgttcat ttcatgatga ccgtgtagtg acagtcaaga ggaagttgtc cagctttcgt aagttatgac gtggtggaag tgacacagat gtgtggaggt gggagtcaga accaagtaca tggacaggaa agtcccagaa gaagaaattc

300

360

420

480

540

600

660

720

780

840

900

930

<400> 2414 Gly Asn 5 Asp Met 1 Glu Leu Leu Ser Glu Glu 20 Pro Glu Ser Met Tyr 35 Leu Val Thr Val Asn 50 Ser Asp Ser His Asn 65 Leu Ser Phe Val Asp 70

Thr Arg Asn Ser 10 Glu Leu Gln Pro 25 Phe Leu Ile Leu 40 Gly Asn Leu Leu 55 His Thr Pro Met Ile Cys Val Thr Ser 75

Phe Leu Leu Leu 15 Gly Phe Gly Leu 30 Phe Leu Leu Ile 45 Ile Leu Ala Tyr 60 Phe Phe Leu Ala Thr Thr Val Pro Lys 80

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Met Leu Val Asn Ile His Thr Gln Arg Lys Val Ile Thr Tyr Glu Ser 85 90 95 Cys Ile Met Gln Met Tyr Phe Phe Ile Leu Phe Val Gly Leu Asp Asn 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Ala Leu Val Ser Trp Ile Met Asn Ile Leu His Ser Leu Leu Glu Thr 145 150 155 160 Leu Met Val Leu Gln Leu Ser Phe Cys Thr His Val Tyr Ile Pro His 165 170 175 Phe Phe Cys Glu Val Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Leu Val Val Tyr Phe Ala Val Val Leu Leu Gly Gly 195 200 205 Ala Pro Leu Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ala Leu Gly Arg Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Thr Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Ser Leu 245 250 255 Gly Val His Leu Ser Ser Thr Val Thr Gln Ser Ser Leu Ser Ser Ala 260 265 270 Thr Ala Ser Val Met Tyr Ala Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285

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Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Glu Ala Leu Asn Leu Leu 290 295 300

Phe Arg Gly Lys Ser 305 <210> 2415 <211> 926 <212> DNA <213> Felis catus <400> 2415

agaaaccact caaggcttcc agtgtttctc ctcttgggac tttctgagaa gccagagatt 60 cagtctgttc tctttgggct gttcctgtct ttgtacctgg tcactgtctt tggcaacctg 120 ctcatcatcc tggccatcat ctcacactcc cacctccaca cgcccatgta cttcttcctg 180 gccaacctgt ccttctcgga catctgcttc acctccacca ccgtcccgaa gatgctgctg 240 aacatccaga cgcagagcaa agtgattacc tacgcaggct gcatcgcgca gatgtatttc 300 ttcacggttt ttggactttt ggacaattta ctcctgactg caatggccta tgaccgcttt 360 gtggccgtct gtcaccccct gcactacacg gtcatcatga accctcggct ttgtgcccag 420 ttactcgccc tgacctggct catcagcact ttgggggccc ttcctgagag tttaaccacg 480 ctgcggctct ctttctgcgc agtaattgaa atcccgcact atttctgtga actccctgag 540 gtcctgcagc tcgcctgctc tgacaccttc atcaataatg ttgtattata tattgtgaca 600 ggcatgatgg gctttgttcc tctcactggg atccttttct cttattcccg aattgtctct 660 tctgtgctga ggatctcaac agcgggggga aagtataaag ctttctccac ctgcgggtct 720 cacctctcag tggtgtcctt gttctatggc acatgcctgg gggtctacct cagttccacc 780 tggacacgtg cctcccagac aggggcgttc gcctcagtcc tgtacaccgt ggtcactccc 840 atgatgaacc ccttcatcta cagcctgagg aacagggaca tgaagagggc cctgagaaag 900 cttctctgta gcatgtcgtc ccccca 926

<210> 2416 <211> 309 <212> PRT <213> Felis catus

Page 2677

069269_0225_SL.TXT <220>

<221> MOD_RES <222> (309)..(309) <223> Any amino acid

<400> 2416 Leu Gly Leu Ser 15 Glu Arg 1 Asn His Ser Arg Leu 5 Pro Val Phe Leu 10 Leu Lys Pro Glu Ile Gln Ser Val Leu Phe Gly Leu Phe Leu Ser Leu Tyr 20 25 30 Leu Val Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala Ile Ile Ser 35 40 45 His Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser 50 55 60 Phe Ser Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys Met Leu Leu 65 70 75 80 Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly Cys Ile Ala 85 90 95 Gln Met Tyr Phe Phe Thr Val Phe Gly Leu Leu Asp Asn Leu Leu Leu 100 105 110 Thr Ala Met Ala Tyr Asp Arg Phe Val Ala Val Cys His Pro Leu His 115 120 125 Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Ala Gln Leu Leu Ala Leu 130 135 140 Thr Trp Leu Ile Ser Thr Leu Gly Ala Leu Pro Glu Ser Leu Thr Thr 145 150 155 160 Leu Arg Leu Ser Phe Cys Ala Val Ile Glu Ile Pro His Tyr Phe Cys 165 170 175 Glu Leu Pro Glu Val Leu Gln Leu Ala Cys Ser Asp Thr Phe Ile Asn

Page 2678

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180 185 190

Asn Val Val Leu Tyr Ile Val Thr Gly Met Met Gly Phe Val Pro Leu 195 200 205 Thr Gly Ile Leu Phe Ser Tyr Ser Arg Ile Val Ser Ser Val Leu Arg 210 215 220 Ile Ser Thr Ala Gly Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser 225 230 235 240 His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Cys Leu Gly Val Tyr 245 250 255 Leu Ser Ser Thr Trp Thr Arg Ala Ser Gln Thr Gly Ala Phe Ala Ser 260 265 270 Val Leu Tyr Thr Val Val Thr Pro Met Met Asn Pro Phe Ile Tyr Ser 275 280 285 Leu Arg Asn Arg Asp Met Lys Arg Ala Leu Arg Lys Leu Leu Cys Ser 290 295 300 Met Ser Ser Pro Xaa

305 <210> 2417 <211> 930 <212> DNA <213> Felis catus <400> 2417

atggaaagag gaaaccaaac aggagctgga cactttctcc tcctgggatt cacagagaag 60 cctttcttct ttgggctgtt tctgtccatg tacctggtca cgttcactgg gaacctgctc 120 ctcatcctgg ccgtcagctc tgactcccac ctccacaccc ccatgtactt cttcctggcc 180 aacctgtcct ttgtagacat ctgcttcacc tccaccaccg tcccgaagat gctctggaac 240 atccagacgc agagaaaact tatcacctgt gcaggctgcc tcagccagat attttttttc 300 atcgtgtttg gatgcctgga caatttactc ctgaccgcga tggcctatga ccgctttgtg 360

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gccatctgtc accccctgca ctacatggtc atcatgaacc cccagctctg taggctgctg 420 gccgtggggt cctggtgcat cagtgtcatg ggctccctgc tcgagacctt gacccttttg 480 aggctgtcct tctgcacaaa catgaaaatc ccacactttt tttgtgatct tcccgaagtc 540 ctgaagcttg cctgttctga caccttcgtc aataccatgg tggtgtattt tgtgactatt 600 gtcctaggtg tttttcctct ctctgggatc ctcttttctt attctaagat tttctcctcc 660 atcctgaaaa tttcatcagc caggggcaag tacaaagcct tttccacgtg tgggtctcac 720 ctctcggtgg tctccttgtt ctatggcacg ggcctcgggg tctacctcag ttctgcagcg 780 acttcatcct ctaggacaag tctggtggcc tcagtgatgt acacgattgt cacccccatg 840 ctgaatccct tcatctacag tctgaggaac agggacatga agggggccct ggggagactc 900 ctcagcaggg cagtgcctct cagtgttggg 930

<210> 2418 <211> 310 <212> PRT <213> Felis catus <400> 2418

Met Glu Arg Gly Asn Gln Thr Gly Ala Gly His Phe Leu Leu Leu Gly 1 5 10 15 Phe Thr Glu Lys Pro Phe Phe Phe Gly Leu Phe Leu Ser Met Tyr Leu 20 25 30 Val Thr Phe Thr Gly Asn Leu Leu Leu Ile Leu Ala Val Ser Ser Asp 35 40 45 Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser Phe 50 55 60 Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys Met Leu Trp Asn 65 70 75 80 Ile Gln Thr Gln Arg Lys Leu Ile Thr Cys Ala Gly Cys Leu Ser Gln 85 90 95

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Ile Phe Phe Phe Ile Val Phe Gly Cys Leu Asp Asn Leu Leu 110 Leu Thr 100 105 Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu His Tyr 115 120 125 Met Val Ile Met Asn Pro Gln Leu Cys Arg Leu Leu Ala Val Gly Ser 130 135 140 Trp Cys Ile Ser Val Met Gly Ser Leu Leu Glu Thr Leu Thr Leu Leu 145 150 155 160 Arg Leu Ser Phe Cys Thr Asn Met Lys Ile Pro His Phe Phe Cys Asp 165 170 175 Leu Pro Glu Val Leu Lys Leu Ala Cys Ser Asp Thr Phe Val Asn Thr 180 185 190 Met Val Val Tyr Phe Val Thr Ile Val Leu Gly Val Phe Pro Leu Ser 195 200 205 Gly Ile Leu Phe Ser Tyr Ser Lys Ile Phe Ser Ser Ile Leu Lys Ile 210 215 220 Ser Ser Ala Arg Gly Lys Tyr Lys Ala Phe Ser Thr Cys Gly Ser His 225 230 235 240 Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Gly Leu Gly Val Tyr Leu 245 250 255 Ser Ser Ala Ala Thr Ser Ser Ser Arg Thr Ser Leu Val Ala Ser Val 260 265 270 Met Tyr Thr Ile Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu 275 280 285 Arg Asn Arg Asp Met Lys Gly Ala Leu Gly Arg Leu Leu Ser Arg Ala 290 295 300

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Val Pro Leu Ser Val Gly 305 310 <210> 2419 <211> 936 <212> DNA <213> Felis catus <400> 2419

atggaaccaa aacaccaaaa aaatgaaaca gcagtctcag aatttcttct ttggggactc 60 tcagaaaggc cagagcatca gatgctcctc tttgggtgtt cctctccatg tacctgatca 120 ctgtgggaac ctcctcatca tcttggccat catcacagac tcccacttcc acgcgcccat 180 gtacttcttc ctctccaacc tgtcccttgt cgatatttct tctcttccac cactgtccca 240 agatgctggt gaaccttcgc acccagagcc gggccatctc ctttgtgggc ggccttgctc 300 agatgtatgc cttccacctg ttcaggacca tggacagctt cctcctggcc ttgatggcca 360 ttgaccactt tgtggcaatt gtccaccctc tacactattc agtcatcatg agcccttgtg 420 tctgtgggtt gctggttggg ggaggccatg gctgatcacc agtctccagt cactcatgca 480 cacctccctc atggttcaac tgaccttctg ttctggctcc gaaatccccc acttcttctg 540 tgatctcatg cccctgctga agctctcctg ctctgacatg cacaacagtg agctggtggt 600 ttttgctttt ggcatcatca tgggcatcag tcccctctcc tgcatccacc tgctttttct 660 gggcagtctt caagatccct tctgctcagg gcaagtggaa agccttctcc acttgtggct 720 cacacctcac cacagtgtca ctgttctatg gcaccgtctg ggccatgtac tttgcagccc 780 acatctgccg cttcctccca gaaggacaag gcagctgccc tgatgtgtgg ggtgctcatc 840 cccatgctga gcccctttat atacagtcta aggaacaagg acatgaaggc agccctgagg 900 aggttcatca gcaaagcagt ctcctgtcag tgctag 936

<210> 2420 <211> 120 <212> PRT <213> Felis catus <400> 2420

Trp Asn Gln Asn Thr Lys Lys Met Lys Gln Gln Ser Gln Asn Phe Phe 1 5 10 15

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Phe Gly Asp Ser Gln Lys Gly Gln Ser Ile Arg Cys Ser Ser Leu Gly 20 25 30 Val Pro Leu His Val Pro Asp His Cys Gly Asn Leu Leu Ile Ile Leu 35 40 45 Ala Ile Ile Thr Asp Ser His Phe His Ala Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Leu Val Asp Ile Ser Ser Leu Pro Pro Leu Ser Gln 65 70 75 80 Asp Ala Gly Glu Pro Ser His Pro Glu Pro Gly His Leu Leu Cys Gly 85 90 95 Arg Pro Cys Ser Asp Val Cys Leu Pro Pro Val Gln Asp His Gly Gln 100 105 110 Leu Pro Pro Gly Leu Asp Gly His 115 120

<210> 2421 <211> 936 <212> DNA <213> Felis catus <400> 2421 atggagaatc agacgtgagt cttcgaattc atcctcctcg gcctctccga gcagccccta 60 cagcagcagg tgctcattgg tgtgtcctgc agcctgtatc tgatcggatg catggggaat 120 ctgctcacca tcctggccat cctcttggac cctcacctcc acagccccat gtacttcttc 180 ctcagcaact tgtctcttct ggacatctgt tttacctcca ccaccgtccc caagatgctg 240 gtgaactatc tgtgcagaca cagcaccatc tccccccagg cttgcctggc acagatgtat 300 ttcttcattg cctttggggc agcggaaagc atccttctct cagtcatggc ttatgaccgc 360 tacctggcca tctgctgccc gctgcgctac atgacgatca tgaacgtcct tcgttgtgcc 420 ttgctagtga ccgtgccctg gacctcggca aacctcatct ccatggtcca taccatcctg 480 atgacccgct tgtccttttg caccaatagg accccacact ttttctgtga cattaatgcc 540

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ttgatcaagc tttcctgctc caacgcgcaa gtcaacgaga tgttgatgct ggtccttggg 600 ggttcggtgg ttctgatgtc ttttgtgtgt atcacggcct cttatacacc tattgctgtg 660 gctgtgtgga aggtgccctc agcccagggg aagtggaaag ctttctctac ctgtagctgt 720 cacctttgtg tcatctctct cttctatggg actattattg gggtctactt caaccctgca 780 tccacacaca ccacccagag ggacatggta gccacagtga tgtatgccat ggtcaccccc 840 atgctgaacc ccttcatcta cagccttcgg aaccgcgatc tgaagggtgc cctcaggaaa 900 cttcttaaag gaaacctctt ggctaagcct ctttga 936

<210> 2422 <211> 117 <212> PRT <213> Felis catus <400> 2422

Gly Glu Ser Asp Val Ser Leu Arg Ile His Pro Pro Arg Pro Leu Arg 1 5 10 15 Ala Ala Pro Thr Ala Ala Gly Ala His Trp Cys Val Leu Gln Pro Val 20 25 30 Ser Asp Arg Met His Gly Glu Ser Ala His His Pro Gly His Pro Leu 35 40 45 Gly Pro Ser Pro Pro Gln Pro His Val Leu Leu Pro Gln Gln Leu Val 50 55 60 Ser Ser Gly His Leu Phe Tyr Leu His His Arg Pro Gln Asp Ala Gly 65 70 75 80 Glu Leu Ser Val Gln Thr Gln His His Leu Pro Pro Gly Leu Pro Gly 85 90 95 Thr Asp Val Phe Leu His Cys Leu Trp Gly Ser Gly Lys His Pro Ser 100 105 110 Leu Ser His Gly Leu

115

Page 2684

069269_0225_SL.TXT <210> 2423 <211> 950 <212> DNA <213> Felis catus <400> 2423

atggccgcca cgctgggccg aaaccacagc tccgtgtctg aattcatcct cgtgggcttc 60 tccaccttcc caaggcatct cctgcccgcc ttcttcctgc tgttcctgct catgtacctg 120 ttcacgctgc tggggaacct gctcatcatg accacagtct ggagtgagcg cagcctgcac 180 acgcccatgt acctcttcct gtgcgccctg tccacctctg agatcctcta caccttggcc 240 atcaccccgc gcctgctggc cgacctgctc tccacccgcc gcaccatcac ctgggcggcc 300 tgtgccagcc agatgttttt ctccttcacg ttcggcttca cccactcctt cctgctcacc 360 gtcatgggct atgaccgcta cgtggccatc tgccaccccc tgcgctacaa tgtgctcatg 420 agcccccgcg gctgcgcctg cctggtggcc tggtcctggg taggtggctc ggtcatgggg 480 ctgttggtga ccacggccgt tttccacctc accttctgtg gacccaatga gatccaccat 540 tttttctgcc acgtgcctcc tgtggtgaag ctggcctgtg gaactgatgt accagtagtg 600 gccaagggcg tggggctggt gtgcatcatg gccctgctgg gctgctgtct cctcatcctc 660 ctctcctatg ccttcattgt ggccgccatc ttgaggatcc cctcagctga gggccggcac 720 aaggccttct ccacctgtgc atcccacctc actgtggtca ttgtgcacta cggctttgcc 780 tctgtcatct atctgaagcc caagggtccc cagtctctgg aaggagacac cctgatgggc 840 atcacctaca cagtcctcac ccccttcctc agccccatca tcttcagtct caggaacaag 900 gagctgaaga ctgccatgac caagaccttc ctcaacaaac tctacccaga 950

<210> 2424 <211> 317 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (317)..(317) <223> Any amino acid

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<400> 2424 Leu Gly Arg Asn His Ser Ser Val Ser Glu Phe 15 Ile Met 1 Ala Ala Thr 5 10 Leu Val Gly Phe Ser Thr Phe Pro Arg His Leu Leu Pro Ala Phe Phe 20 25 30 Leu Leu Phe Leu Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu 35 40 45 Ile Met Thr Thr Val Trp Ser Glu Arg Ser Leu His Thr Pro Met Tyr 50 55 60 Leu Phe Leu Cys Ala Leu Ser Thr Ser Glu Ile Leu Tyr Thr Leu Ala 65 70 75 80 Ile Thr Pro Arg Leu Leu Ala Asp Leu Leu Ser Thr Arg Arg Thr Ile 85 90 95 Thr Trp Ala Ala Cys Ala Ser Gln Met Phe Phe Ser Phe Thr Phe Gly 100 105 110 Phe Thr His Ser Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly 130 135 140 Cys Ala Cys Leu Val Ala Trp Ser Trp Val Gly Gly Ser Val Met Gly 145 150 155 160 Leu Leu Val Thr Thr Ala Val Phe His Leu Thr Phe Cys Gly Pro Asn 165 170 175 Glu Ile His His Phe Phe Cys His Val Pro Pro Val Val Lys Leu Ala 180 185 190 Cys Gly Thr Asp Val Pro Val Val Ala Lys Gly Val Gly Leu Val Cys 195 200 205

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Ile Met Ala Leu Leu Gly Cys 215 Cys Leu Leu Ile Leu 220 Leu Ser Tyr Ala 210 Phe Ile Val Ala Ala Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His 225 230 235 240 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Val His 245 250 255 Tyr Gly Phe Ala Ser Val Ile Tyr Leu Lys Pro Lys Gly Pro Gln Ser 260 265 270 Leu Glu Gly Asp Thr Leu Met Gly Ile Thr Tyr Thr Val Leu Thr Pro 275 280 285 Phe Leu Ser Pro Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Thr 290 295 300 Ala Met Thr Lys Thr Phe Leu Asn Lys Leu Tyr Pro Xaa

305 310 315

<210> 2425 <211> 1021 <212> DNA <213> Felis catus <400> 2425 tcaggagctt agaggaatga gttttctctg gatgcttttc tttatagcat tcttgagctc 60 cttattcctg agactgaaaa tgatcggact gagaaaggga gtgaagactg tataggtggt 120 ggccatcagg gtattactgt ccatagaatg ggggcctttg ggcttgaggt agataatgga 180 ggcaaagcca tagtgcacaa tgaccacagt gaggtgggac acacatgtgg agaaagtctt 240 gtgcctgcct tcagcagagg ggatccgcaa tatggcggcc acgatgaaga cataggagag 300 gacgatgagg aataaacagc ccatcagagc tgagacacac accaggatca cacccaaggt 360 gacggaggaa ttctcattcc cacaggccaa ctttagaagg gaaaacacat ggcagaaaaa 420 atggcggatc atgttagatc cacagaaggt gaggtgaaaa actatcaggg tcaccatcat 480 ccccatgact gagccaccag cccaggtcca ggacacaagg cgggcacagc cacggttgct 540

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catgagcaca tggtagcgca gggggtggca gatggccacg tagcggtcgt agcccatgat 600 catgagcagg aaggagtgtg tgaagccaaa cgtgaaggag aaaaacatct ggctggcaca 660 ggccgcccag gtgatggtgc ggtgggtgaa gagcatgtca accagcatgc gaggggtgat 720 ggcaacggtg aacagaatct cggaggtgga cagggcgcac aggaagaggt acatgggtgt 780 gtgcaggctg cgctcgctcc agactgtggt catgatgagc aggttcccca gcagcgtgaa 840 caggtacatg agcaggtaca gcaggaagaa ggcgggcagg agatgctgtg ggaaggtgga 900 gaagcccacg aggatgaact cagtcatcat gctatagttc tgaccagcca tgggtgctgc 960 atctggtgag atcagaaagg gaatgaaggt tcgtaattta tcccatgaat aacaaggttg 1020

a 1021 <210> 2426 <211> 316 <212> PRT <213> Felis catus

<400> 2426 Tyr Ser Met Met Thr Glu Phe Ile Leu Val Gly Met Ala 1 Gly Gln Asn 5 10 15 Phe Ser Thr Phe Pro Gln His Leu Leu Pro Ala Phe Phe Leu Leu Tyr 20 25 30 Leu Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Thr 35 40 45 Thr Val Trp Ser Glu Arg Ser Leu His Thr Pro Met Tyr Leu Phe Leu 50 55 60 Cys Ala Leu Ser Thr Ser Glu Ile Leu Phe Thr Val Ala Ile Thr Pro 65 70 75 80 Arg Met Leu Val Asp Met Leu Phe Thr His Arg Thr Ile Thr Trp Ala 85 90 95 Ala Cys Ala Ser Gln Met Phe Phe Ser Phe Thr Phe Gly Phe Thr His 100 105 110

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Ser Phe Leu 115 Leu Met Ile Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys 120 125 His Pro Leu Arg Tyr His Val Leu Met Ser Asn Arg Gly Cys Ala Arg 130 135 140 Leu Val Ser Trp Thr Trp Ala Gly Gly Ser Val Met Gly Met Met Val 145 150 155 160 Thr Leu Ile Val Phe His Leu Thr Phe Cys Gly Ser Asn Met Ile Arg 165 170 175 His Phe Phe Cys His Val Phe Ser Leu Leu Lys Leu Ala Cys Gly Asn 180 185 190 Glu Asn Ser Ser Val Thr Leu Gly Val Ile Leu Val Cys Val Ser Ala 195 200 205 Leu Met Gly Cys Leu Phe Leu Ile Val Leu Ser Tyr Val Phe Ile Val 210 215 220 Ala Ala Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His Lys Thr Phe 225 230 235 240 Ser Thr Cys Val Ser His Leu Thr Val Val Ile Val His Tyr Gly Phe 245 250 255 Ala Ser Ile Ile Tyr Leu Lys Pro Lys Gly Pro His Ser Met Asp Ser 260 265 270 Asn Thr Leu Met Ala Thr Thr Tyr Thr Val Phe Thr Pro Phe Leu Ser 275 280 285 Pro Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Asn Ala Ile Lys 290 295 300 Lys Ser Ile Gln Arg Lys Leu Ile Pro Leu Ser Ser

305 310 315

Page 2689

069269_0225_SL.TXT <210> 2427 <211> 679 <212> DNA <213> Felis catus <400> 2427 tggaagcttc tcattatggc attcttgagc tccttattcc tgaggctgaa atgatcaggc 60 tgagaaaggg gtgaagacta tataggtggt ggccatcagg gtgttactgt ccatagaatg 120 ggggcccttg gacttgaggt agataatgga ggcaaagccg tagtgcacaa tgaccacagt 180 gaggtgggac acacacgtgg agaaagtctt gtgcctgcct tcagcagaag ggatccgcaa 240 tatggcggcc acgatgaaga cataggagag gatgatgagg aataaacagc ccatcagagc 300 tgagacacac accaggatca cagccaaggt gacggaggct gtttctttcc cacaggccaa 360 tttcaaaagg gaaaacacat ggcatagaaa atggtggatc acattagacc cacagaaggt 420 gaggtgaaaa actatcaggg tcaccatcat ccccatgatc gagccaccag cccaggacca 480 ggacacgagg cgggcacagc cacgggggct catgagcaca ttgtagcgca gggggtggca 540 gatggccacg tagcggtcat agcccatgat cacgagcagg aaggagtggg tgaagccaaa 600 cgtgaaggag aaaaacatct ggctggcaca ggccgtccaa gtgatggtgc ggtgggtgga 660 gagcaggtcg gccagcatg 679 <210> 2428 <211> 207 <212> PRT <213> Felis catus

<400> 2428 Leu Ser Thr His Arg Thr Ile Thr Trp Thr Ala Met 1 Leu Ala Asp Leu 5 10 15 Cys Ala Ser Gln Met Phe Phe Ser Phe Thr Phe Gly Phe Thr His Ser 20 25 30 Phe Leu Leu Val Ile Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His 35 40 45 Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly Cys Ala Arg Leu Page 2690

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50 55 60

Val 65 Ser Trp Ser Trp Ala Gly Gly Ser Ile Met Gly Met Met Val Thr 70 75 80 Leu Ile Val Phe His Leu Thr Phe Cys Gly Ser Asn Val Ile His His 85 90 95 Phe Leu Cys His Val Phe Ser Leu Leu Lys Leu Ala Cys Gly Lys Glu 100 105 110 Thr Ala Ser Val Thr Leu Ala Val Ile Leu Val Cys Val Ser Ala Leu 115 120 125 Met Gly Cys Leu Phe Leu Ile Ile Leu Ser Tyr Val Phe Ile Val Ala 130 135 140 Ala Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His Lys Thr Phe Ser 145 150 155 160 Thr Cys Val Ser His Leu Thr Val Val Ile Val His Tyr Gly Phe Ala 165 170 175 Ser Ile Ile Tyr Leu Lys Ser Lys Gly Pro His Ser Met Asp Ser Asn 180 185 190 Thr Leu Met Ala Thr Thr Tyr Ile Val Phe Thr Pro Phe Ser Ala 195 200 205

<210> 2429 <211> 1031 <212> DNA <213> Felis catus <400> 2429 tcaggagctt aagggactga attttctctg gaagcttttc tttatggcat tcttgagctc cttattcctg aggctgaaaa tgatcggact gagaaagggg gtgaagacta tataggtggt agccatcagg gtgttactgt ccatagaatg ggggcccttg ggcttgaggt agataatgga ggcaaagcca tagtgcacaa tgaccacagt gaggtgggac acacacgtgg agaaggtctt Page 2691

120

180

240

069269_0225_SL.TXT gtgcctgccc tcagcagagg ggatccgcaa tatggcggcc acgatgaaga cataggagag gacaatgagg aataagcagc ccatcagagc tgagacacat actaggatca cacccaaggt gacagaggat gtctccttcc cacaggtcaa ctttagaagg gaaagcacgt ggcaggcaaa atggtggatc acattagacc cacagaaggt gaggtgaaaa actatcagcg tcaacattat ccccatgact gagccaccaa cccagaacca agacacaagg cgggcacagc cacggttgct catgagcaca ttgtagcgca gggggtggca gatggccacg tagcggtcgt agcccatgat catgagcagg aaggagtgtg tgaagccaaa cgtgaaggag aaaaacatct ggctggcaca ggccatccag gtgatggtgc ggtgggtgga gagcatgtca accagcatgc gaggggtgac ggcaacggtg aacagaatct cggaggtaga cagggcgcaa aggaagaggt acatgggcgt gtgcaggctg cgctcgctcc agaccgtggc catgatgagc aggttcccca gcagcgtgaa caggtacatg agcaggtaca gcaggaagaa agcaggcagg agatgccgtg ggaagttaga gaatcccaca aggatgaact cagtcaccac gctgtagttc tgaccaggca cgggtgctgc atctggtgag atcagaaagg gaatgaaggt gcgtaattta tcccatgaat aacaaagatg attcagtgtc a <210> 2430 <211> 342 <212> PRT <213> Felis catus

300

360

420

480

540

600

660

720

780

840

900

960

1020

1031

<400> 2430 Ser Trp Asp Lys 10 Leu Arg Thr Phe Ile 15 Thr 1 Leu Asn His Leu Cys 5 Tyr Pro Phe Leu Ile Ser Pro Asp Ala Ala Pro Val Pro Gly Gln Asn Tyr 20 25 30 Ser Val Val Thr Glu Phe Ile Leu Val Gly Phe Ser Asn Phe Pro Arg 35 40 45 His Leu Leu Pro Ala Phe Phe Leu Leu Tyr Leu Leu Met Tyr Leu Phe 50 55 60

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Thr 65 Leu Leu Gly Asn Leu Leu Ile Met Ala Thr Val Trp Ser Glu Arg 70 75 80 Ser Leu His Thr Pro Met Tyr Leu Phe Leu Cys Ala Leu Ser Thr Ser 85 90 95 Glu Ile Leu Phe Thr Val Ala Val Thr Pro Arg Met Leu Val Asp Met 100 105 110 Leu Ser Thr His Arg Thr Ile Thr Trp Met Ala Cys Ala Ser Gln Met 115 120 125 Phe Phe Ser Phe Thr Phe Gly Phe Thr His Ser Phe Leu Leu Met Ile 130 135 140 Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Asn 145 150 155 160 Val Leu Met Ser Asn Arg Gly Cys Ala Arg Leu Val Ser Trp Phe Trp 165 170 175 Val Gly Gly Ser Val Met Gly Ile Met Leu Thr Leu Ile Val Phe His 180 185 190 Leu Thr Phe Cys Gly Ser Asn Val Ile His His Phe Ala Cys His Val 195 200 205 Leu Ser Leu Leu Lys Leu Thr Cys Gly Lys Glu Thr Ser Ser Val Thr 210 215 220 Leu Gly Val Ile Leu Val Cys Val Ser Ala Leu Met Gly Cys Leu Phe 225 230 235 240 Leu Ile Val Leu Ser Tyr Val Phe Ile Val Ala Ala Ile Leu Arg Ile 245 250 255 Pro Ser Ala Glu Gly Arg His Lys Thr Phe Ser Thr Cys Val Ser His 260 265 270

Page 2693

Leu Thr Val 275 Val Ile Val His 069269_0225_SL.TXT Tyr Gly Phe Ala Ser Ile 280 285 Ile Tyr Leu Lys Pro Lys Gly Pro His Ser Met Asp Ser Asn Thr Leu Met Ala Thr 290 295 300 Thr Tyr Ile Val Phe Thr Pro Phe Leu Ser Pro Ile Ile Phe Ser Leu 305 310 315 320 Arg Asn Lys Glu Leu Lys Asn Ala Ile Lys Lys Ser Phe Gln Arg Lys 325 330 335

Phe Ser Pro Leu Ser Ser 340 <210> 2431 <211> 988 <212> DNA <213> Felis catus <400> 2431

cttcattccc cttctgatct caccagatgc agcacccatg gctggtcaga actacagcat 60 ggtgactgag ttcatcctcg tgggattctc taacttccca cggcatcttc tgcccgcctt 120 cttcctgctg tacctgctca tgtacctgtt cacgctgctg gggaacctgc tcatcatggc 180 cacagtctgg agcgagcgca gcctgcacac gcccatgtac ctcttcctgt gcgccctgtc 240 cacctccgaa attctgttca ccgttgccat cacccctcgc atgctggttg acatgctctc 300 cacccaccac accatcacct gggcggcctg tgccagccag atgtttttct ccttcacgtt 360 tggcttcaca cactccttcc tgctcatgat catgggctac gaccgctatg tggccatctg 420 ccaccccctg cgctacaatg tgctcatgag cccccgtggc tgtgcccgcc ttgtgtcctg 480 gtcctgggcc ggtggctcag taatagggat gatgtcgacc ctgatagttt ttcacctcac 540 cttctgtggg tgtaatgtga tccaccattt tctatgccat gtgttttccc tcttgaaatt 600 ggcctgtggg aaagaaacag cctccgtcac cttggctgtg atcctggtgt gtgtctcagc 660 tctgatgggc tgcttattcc tcatcgtcct ctcctatgtc ttcattgtgg ccgccatatt 720 gcggatcccc tctgctgagg gcaggcacaa gaccttctcc acatgtgtgt cccacctcac 780

Page 2694

069269_0225_SL.TXT ggtggtcatt gtgcactaca gttttgcctc cattatctac ctcaagccca agggccccca ttctatggac agtaacaccc tgatggccac cacctatata gtcttcaccc cctttctcag cccaatcatt ttcagcctca gaaataagga actcaagaat gccataaaga aaagcttcca gagaaaattc agtctcctaa gctcctga

840

900

960

988 <210> 2432 <211> 316 <212> PRT <213> Felis catus

<400> 2432 Tyr Ser Met Val Thr Glu Phe Ile Leu Val Gly Met Ala 1 Gly Gln Asn 5 10 15 Phe Ser Asn Phe Pro Arg His Leu Leu Pro Ala Phe Phe Leu Leu Tyr 20 25 30 Leu Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Ala 35 40 45 Thr Val Trp Ser Glu Arg Ser Leu His Thr Pro Met Tyr Leu Phe Leu 50 55 60 Cys Ala Leu Ser Thr Ser Glu Ile Leu Phe Thr Val Ala Ile Thr Pro 65 70 75 80 Arg Met Leu Val Asp Met Leu Ser Thr His His Thr Ile Thr Trp Ala 85 90 95 Ala Cys Ala Ser Gln Met Phe Phe Ser Phe Thr Phe Gly Phe Thr His 100 105 110 Ser Phe Leu Leu Met Ile Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 His Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly Cys Ala Arg 130 135 140 Leu Val Ser Trp Ser Trp Ala Gly Gly Ser Val Ile Gly Met Met Ser 1 Page 2695

0 6926 >9_02 25_S iL.TX T 145 150 155 160 Thr Leu Ile Val Phe His Leu Thr Phe Cys Gly Cys Asn Val Ile His 165 170 175 His Phe Leu Cys His Val Phe Ser Leu Leu Lys Leu Ala Cys Gly Lys 180 185 190 Glu Thr Ala Ser Val Thr Leu Ala Val Ile Leu Val Cys Val Ser Ala 195 200 205 Leu Met Gly Cys Leu Phe Leu Ile Val Leu Ser Tyr Val Phe Ile Val 210 215 220 Ala Ala Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His Lys Thr Phe 225 230 235 240 Ser Thr Cys Val Ser His Leu Thr Val Val Ile Val His Tyr Ser Phe 245 250 255 Ala Ser Ile Ile Tyr Leu Lys Pro Lys Gly Pro His Ser Met Asp Ser 260 265 270 Asn Thr Leu Met Ala Thr Thr Tyr Ile Val Phe Thr Pro Phe Leu Ser 275 280 285 Pro Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Asn Ala Ile Lys 290 295 300 Lys Ser Phe Gln Arg Lys Phe Ser Leu Leu Ser Ser 305 310 315

<210> 2433 <211> 960 <212> DNA <213> Felis catus <400> 2433 ttagatgctg gagggatgaa gttttctgag gaaggtcttg gtcatggctg tcttcagctc cttgttcctg agactgaaga tgatggggct gaggaagggg gtgaggaccg tgtaggtgat

120

Page 2696

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ggccatcagg gtgtctcttt ccagatactg gggacccttg ggcttgaggt agacgacaga 180 ggcaaagcca tagtgcacaa tgaccacagt gaggtgggac gcacaggtgg agaaggcctt 240 gtgccggccc tcagctgagg ggatcctcaa gatggtggcc acaatgaagg cataggagag 300 gaggatgagg agacagcagc ccagcagggc catgatgcac accagcccca cgcccttggc 360 cactgctggt acatcagttc cacaggccag cttcaagaga gggggcacat gacataaaaa 420 atggtggatc tcattgggtc cacagaaggt gaggtggaaa acggccgtgg tcaccaccag 480 ccccgtgacc gagccaccta cccaggacca ggccaccagg caggcgcagc cgcgggggct 540 catgagcaca ttgtagcgca gggggtggca gatggccacg tagcggtcgt agcccatgac 600 ggtgagcagg aaggagtggg tgaagccgaa cgtgaaggag aaaaacatct ggctggcaca 660 ggccgcccag gtgatggtgt ggcgggtgga gagcaggtcg gccagcaggc gcggggtgat 720 ggccaaggtg tagaggatct cggaggtgga cagggcacac aggaagaggt acatgggcgt 780 gtgcaggctg cgctcactcc agactgtggt catgatgagc aggttcccca gcagcgtgaa 840 caggtacatg agcaggaaca gcaggaagaa ggcgggcagg agatgccttg ggaaggtgga 900 gaagcccacg aggatgaatt cggacacgga gctgtggttt cggcccagcg tggcagccat 960

<210> 2434 <211> 319 <212> PRT <213> Felis catus <400> 2434

Met Ala Ala Thr Leu Gly Arg Asn His Ser Ser Val Ser Glu Phe Ile 1 5 10 15 Leu Val Gly Phe Ser Thr Phe Pro Arg His Leu Leu Pro Ala Phe Phe 20 25 30 Leu Leu Phe Leu Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu 35 40 45 Ile Met Thr Thr Val Trp Ser Glu Arg Ser Leu His Thr Pro Met Tyr 50 55 60

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Leu 65 Phe Leu Cys Ala Leu Ser Thr Ser Glu Ile Leu Tyr Thr Leu Ala 70 75 80 Ile Thr Pro Arg Leu Leu Ala Asp Leu Leu Ser Thr Arg His Thr Ile 85 90 95 Thr Trp Ala Ala Cys Ala Ser Gln Met Phe Phe Ser Phe Thr Phe Gly 100 105 110 Phe Thr His Ser Phe Leu Leu Thr Val Met Gly Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly 130 135 140 Cys Ala Cys Leu Val Ala Trp Ser Trp Val Gly Gly Ser Val Thr Gly 145 150 155 160 Leu Val Val Thr Thr Ala Val Phe His Leu Thr Phe Cys Gly Pro Asn 165 170 175 Glu Ile His His Phe Leu Cys His Val Pro Pro Leu Leu Lys Leu Ala 180 185 190 Cys Gly Thr Asp Val Pro Ala Val Ala Lys Gly Val Gly Leu Val Cys 195 200 205 Ile Met Ala Leu Leu Gly Cys Cys Leu Leu Ile Leu Leu Ser Tyr Ala 210 215 220 Phe Ile Val Ala Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His 225 230 235 240 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Val His 245 250 255 Tyr Gly Phe Ala Ser Val Val Tyr Leu Lys Pro Lys Gly Pro Gln Tyr 260 265 270

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Leu Glu Arg 275 Asp Thr Leu Met 069269_0225_SL.TXT Ala Ile Thr Tyr Thr Val 280 285 Leu Thr Pro Phe Leu Ser Pro Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Thr 290 295 300 Ala Met Thr Lys Thr Phe Leu Arg Lys Leu His Pro Ser Ser Ile 305 310 315

<210> 2435 <211> 988 <212> DNA <213> Felis catus <400> 2435 tcaggagctt aaaggactga attttctctg gaagcttttc tttatggcgt tcttgagctc 60 cttattcctg agactgaaaa tgatcgggct gagaaagggg gtgaagactg tataggtggt 120 ggccatcagg gtgttactgt ccatagaatg ggggcccttg ggcttgaggt agataatgga 180 ggcaaagccg tagtgcacaa tgaccactgt gaggtgggac acacacgtgg agaaggtctt 240 gtgcctgccc tcagcagagg ggatccgcaa tatggcagcc acaatgaaga cataggagag 300 gacgatgagg aataaacagc ccatcagagc tgagacacac accaggatca cacccaaggt 360 gacagaggaa ttctcattcc cacaggccaa ctttagaagg gaaagcacgt ggcagacaaa 420 atggtggatc acattagacc cacagaaggt gaggtgaaaa actatcaggg tcaacatcat 480 tcccatgact gagccaccgg cccaggacaa ggacacaaag cgggcacagc cacgggggct 540 catgagcaca ttgtagcgca gggggtggca gatggccacg tagcggtcat agcccatgat 600 catgagcagg aaggagtgtg tgaagccaaa cgtgaaggag aaaaacatct ggctggcaca 660 ggccgtccag gtgatggtgc ggtgggtgga gagcatgtca accagcatgc gaggggtgac 720 agcaacggtg aacagaatct cggaggtgga cagggcgcac aggaagaggt acatgggcgt 780 gtgcaggctg cgttcgctcc agactgtggt catgatgagc aggttcccca gcagcgtgaa 840 caggtacatg agcaggtaca gcaagaagaa ggtgggcaga agatgccttg ggaagttaga 900 gaatcccaca aggatgaact cagtcaccat gctatagttc tgaccagcca tgggtgctac 960 atctggtgag atcagaaggg gaatgaag 988

Page 2699

069269_0225_SL.TXT <210> 2436 <211> 316 <212> PRT <213> Felis catus

<400> 2436 Met 1 Ala Gly Gln Asn 5 Tyr Ser Met Val Thr Glu Phe Ile Leu Val Gly 10 15 Phe Ser Asn Phe Pro Arg His Leu Leu Pro Thr Phe Phe Leu Leu Tyr 20 25 30 Leu Leu Met Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Met Thr 35 40 45 Thr Val Trp Ser Glu Arg Ser Leu His Thr Pro Met Tyr Leu Phe Leu 50 55 60 Cys Ala Leu Ser Thr Ser Glu Ile Leu Phe Thr Val Ala Val Thr Pro 65 70 75 80 Arg Met Leu Val Asp Met Leu Ser Thr His Arg Thr Ile Thr Trp Thr 85 90 95 Ala Cys Ala Ser Gln Met Phe Phe Ser Phe Thr Phe Gly Phe Thr His 100 105 110 Ser Phe Leu Leu Met Ile Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 His Pro Leu Arg Tyr Asn Val Leu Met Ser Pro Arg Gly Cys Ala Arg 130 135 140 Phe Val Ser Leu Ser Trp Ala Gly Gly Ser Val Met Gly Met Met Leu 145 150 155 160 Thr Leu Ile Val Phe His Leu Thr Phe Cys Gly Ser Asn Val Ile His 165 170 175

His Phe Val Cys His Val Leu Ser Leu Leu Lys Leu Ala Cys Gly Asn Page 2700

180

069269_0225_SL.TXT 185 190

Glu Asn Ser 195 Ser Val Thr Leu Gly Val Ile Leu Val Cys Val Ser Ala 200 205 Leu Met Gly Cys Leu Phe Leu Ile Val Leu Ser Tyr Val Phe Ile Val 210 215 220 Ala Ala Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg His Lys Thr Phe 225 230 235 240 Ser Thr Cys Val Ser His Leu Thr Val Val Ile Val His Tyr Gly Phe 245 250 255 Ala Ser Ile Ile Tyr Leu Lys Pro Lys Gly Pro His Ser Met Asp Ser 260 265 270 Asn Thr Leu Met Ala Thr Thr Tyr Thr Val Phe Thr Pro Phe Leu Ser 275 280 285 Pro Ile Ile Phe Ser Leu Arg Asn Lys Glu Leu Lys Asn Ala Ile Lys 290 295 300 Lys Ser Phe Gln Arg Lys Phe Ser Pro Leu Ser Ser 305 310 315

<210> 2437 <211> 914 <212> DNA <213> Felis catus <400> 2437

aatcagtcag tgacctcaga cttcactctc atggggctct tgagccactc ggggccacat 60 ctggtcctat tctcccttgt ggctgtcata ttcactatgg gccttctggg aaacatcatc 120 ctgctcttcc tgatccacac agactccagg ctccacacac ccatgtactt cctgctcagt 180 caactctcct tattggatgt tggctttcta ctggtcacca tccccaagat ggcagccaac 240 ttcctgcagg gagagggttc catctccttt gggggttgtg cagctcagat gttcttcctg 300 atgctgatgg gtgtctctga gggtgtcctg ctatccctca tgtcttacga ccgctatgtt 360

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gctgtgtgcc accccctgca ttatcctgta ctcatgagac gtcaggtctg cctgctcatg 420 gtgggcacct cctggttgtc aggtgtgctc gtggcctcca tccagacctc catcaccctg 480 cacttcccct actgtgcctc acacactgtg gatcacttct tctgtgagct accggctctg 540 ctgaagctct cttgtgcaga cacctctgct tatgagttgt cgctgtccat ctcaggagtg 600 ctgatcttgc ttcttcccct gtcactcatc accacctcct acagccatgt gttgagggcc 660 gttctctgca tgcactcagc agagacccga cacaaggcct tcaccacctg ttcctctcac 720 atcactgttg tggggctctt ttatggggca gccatgttca tgtacatggt tccaggcacc 780 taccacagcc cacagcaaga caatgtggtc tccctcttct atagccttgt cacccccaca 840 ctcaaccccc tcatctatag cctgagaaac agagaggttc aaatggcttt ggtcaaggtt 900 cttggcagaa ctgg 914

<210> 2438 <211> 305 <212> PRT <213> Felis catus <400> 2438

Asn Gln Ser Val Thr Ser Asp Phe Thr Leu Met Gly Leu Leu Ser His 1 5 10 15 Ser Gly Pro His Leu Val Leu Phe Ser Leu Val Ala Val Ile Phe Thr 20 25 30 Met Gly Leu Leu Gly Asn Ile Ile Leu Leu Phe Leu Ile His Thr Asp 35 40 45 Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser Gln Leu Ser Leu 50 55 60 Leu Asp Val Gly Phe Leu Leu Val Thr Ile Pro Lys Met Ala Ala Asn 65 70 75 80 Phe Leu Gln Gly Glu Gly Ser Ile Ser Phe Gly Gly Cys Ala Ala Gln 85 90 95

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Met Phe Phe Leu Met Leu Met Gly Val Ser Glu Gly Val Leu Leu Ser 100 105 110 Leu Met Ser Tyr Asp Arg Tyr Val Ala Val Cys His Pro Leu His Tyr 115 120 125 Pro Val Leu Met Arg Arg Gln Val Cys Leu Leu Met Val Gly Thr Ser 130 135 140 Trp Leu Ser Gly Val Leu Val Ala Ser Ile Gln Thr Ser Ile Thr Leu 145 150 155 160 His Phe Pro Tyr Cys Ala Ser His Thr Val Asp His Phe Phe Cys Glu 165 170 175 Leu Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr Ser Ala Tyr Glu 180 185 190 Leu Ser Leu Ser Ile Ser Gly Val Leu Ile Leu Leu Leu Pro Leu Ser 195 200 205 Leu Ile Thr Thr Ser Tyr Ser His Val Leu Arg Ala Val Leu Cys Met 210 215 220 His Ser Ala Glu Thr Arg His Lys Ala Phe Thr Thr Cys Ser Ser His 225 230 235 240 Ile Thr Val Val Gly Leu Phe Tyr Gly Ala Ala Met Phe Met Tyr Met 245 250 255 Val Pro Gly Thr Tyr His Ser Pro Gln Gln Asp Asn Val Val Ser Leu 260 265 270 Phe Tyr Ser Leu Val Thr Pro Thr Leu Asn Pro Leu Ile Tyr Ser Leu 275 280 285 Arg Asn Arg Glu Val Gln Met Ala Leu Val Lys Val Leu Gly Arg Thr 290 295 300

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Gly

305 <210> 2439 <211> 919 <212> DNA <213> Felis catus <400> 2439

gtctctgagt tcctgctcct gggcctctcg gggaactgaa agcaacagca gctgctcctc 60 atactcttcc tgagcatgtc cctggtcaca ggactgggga acctgttcat cgtcctggcc 120 atcgccaccg actcccaact ccacacgccc atgtacttct tcctggctaa gctggccttt 180 gtggacattt gcttcacctc caccaccatt cccaagatgc tggccaacct cgtgttagga 240 cacaaaggga tcccttaatg caggctgcct gacccagatc ttcttcttca tctggtttgc 300 tggcatcgat agcttccttc tgatggccat ggcctatgac cgctatgcgg ccatctgtca 360 ccctctgcac tacgctgtgt ctgtgatgcc acacctctgt ggcctcctgg tggctgcatc 420 ctggactgca gccttcggga acgccctgac ccacacagta ttactgactc gcctcttgtt 480 ctgcacccac aaccaggttc cccatctctt ttgtgacctc agccctctgc tgaagctggc 540 ctgctctggc acctttctca ataatgcaat gttgtacacc gggggcaccc tacccatcat 600 cacccccttt gtgggtatct tggtctccta cacacgcatc tttgcctccg tgctgaggat 660 cccatccacg agaggcaagc agaaggcttt ctccacctgt ggctctcacc tctctgtggt 720 gtccctgtcc tatgggacac tcatcagggt ttatttcagc cctatgtcct cccacacagc 780 ccagaaggac acggccgctg cagtgatgta cgtggtggtc actcccatgc tgaacccctt 840 catgtacagc ctacgcaaca gtgacaggat gggtgctttg ggggccctca tcggtaggaa 900 gccagtgttt attcagtga 919

<210> 2440 <211> 198 <212> PRT <213> Felis catus <400> 2440

Met Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His Pro Leu His 1 5 10 15

Page 2704

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Tyr Ala Val Ser 20 Val Met Pro His Leu Cys Gly Leu Leu Val Ala Ala 25 30 Ser Trp Thr Ala Ala Phe Gly Asn Ala Leu Thr His Thr Val Leu Leu 35 40 45 Thr Arg Leu Leu Phe Cys Thr His Asn Gln Val Pro His Leu Phe Cys 50 55 60 Asp Leu Ser Pro Leu Leu Lys Leu Ala Cys Ser Gly Thr Phe Leu Asn 65 70 75 80 Asn Ala Met Leu Tyr Thr Gly Gly Thr Leu Pro Ile Ile Thr Pro Phe 85 90 95 Val Gly Ile Leu Val Ser Tyr Thr Arg Ile Phe Ala Ser Val Leu Arg 100 105 110 Ile Pro Ser Thr Arg Gly Lys Gln Lys Ala Phe Ser Thr Cys Gly Ser 115 120 125 His Leu Ser Val Val Ser Leu Ser Tyr Gly Thr Leu Ile Arg Val Tyr 130 135 140 Phe Ser Pro Met Ser Ser His Thr Ala Gln Lys Asp Thr Ala Ala Ala 145 150 155 160 Val Met Tyr Val Val Val Thr Pro Met Leu Asn Pro Phe Met Tyr Ser 165 170 175 Leu Arg Asn Ser Asp Arg Met Gly Ala Leu Gly Ala Leu Ile Gly Arg 180 185 190 Lys Pro Val Phe Ile Gln

<210> 2441 <211> 924 <212> DNA

195

Page 2705

069269_0225_SL.TXT <213> Felis catus <400> 2441 atgttggaga gtcactctag tgccactgac ttctatctca taggcttccc tggatcccca 60 gaattatgcc atattctatt tgctaccttc ttcttcttct gtttggtgac tcatggggaa 120 catgttcatc cttgtgattg tctgtgttga taaatgtttg cagtccctca tgtatttctt 180 ccttggccac ctctctgtcc tagaaatctt gctcatatct actgctgttc ccttggtgct 240 ctgcaggttg ctgcttcctg ggatgcagac aatatctttg acaacatgtg gtgcacaatt 300 atatttgtac ctttctttgg gcacgtcgga attcatatta atgggagtga tggctgtaga 360 ccgttatgtg gctgtctgta accctttgag gtacaacatc attatggaca gccacacctg 420 catctggatg gttattgtgt catgggtgtt ttggtttcta tttcaaatct ggccagtcta 480 tgccatgttt cagcttacct tctgcaaatc aaatgtgata gaccattttt ttatgtgacc 540 gagggcaatt gtttgaacta tcctgtgatg acagccattt cacacagttt attctttttt 600 aaatggctgt tttcattatc attggtgctt tgatcctaca gtcatctcct acacctacat 660 catctccacc atcctcaaga tcccctcagc ctcgggccgg agcaaagcct tccctacgtg 720 tgcctctcac ttcacatttg ttgtgatcgg ctgtggcacc tgcttgttcc tctatgtgaa 780 acccaagcaa atgcaggcag cttgagtaca acagggtagc gtcactgatg gttttagtgg 840 tgaccccttt cctgaaccca ttcatcttca ccctccggaa tgacaaattc atagaggcct 900 ttcgagatgt catgaaacgc tgct 924 <210> 2442 <211> 78 <212> PRT <213> Felis catus

<400> 2442 Ser Arg Lys Ala Ser Met Asn Leu Ser Phe Arg Gln 1 Arg Phe Met Thr 5 10 15 Arg Val Lys Met Asn Gly Phe Arg Lys Gly Val Thr Thr Lys Thr Ile 20 25 30 Ser Asp Ala Thr Leu Leu Tyr Ser Ser Cys Leu His Leu Leu Gly Phe 35 40 45

Page 2706

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His Ile Glu Glu Gln Ala Gly Ala Thr Ala Asp His Asn Lys Cys Glu 50 55 60

Val Arg Gly Thr Arg Arg Glu Gly Phe Ala Pro Ala Arg Gly 65 70 75 <210> 2443 <211> 945 <212> DNA <213> Felis catus <400> 2443

atgttgaaga attattctag cgccactgaa ttttatctac ttggcttcca tggctccaaa 60 gaactacacg atattctttt tgccactttc ttctttctct actcagtgac agtcatgggg 120 aacatggtca tcattgtgat tgtctgtgtt gataaacgtc tgcagtcccc catgtatttc 180 ttccttggcc acctctcagt cctagagatc ctgatcacat cggttgctgt ccccttaatg 240 ctctgggggc tgctgcttcc agggatgcag gcaatgtctt tgacagcctg tagtgcacaa 300 ttatatttgt acctctcttt gggtacgtcg gagttagtat taattggagc aatggctgtg 360 gaccgttatg tggctgtctg taaccctctg aggtacaaca tcattatgga cagccacacc 420 tgcatctggg tggtcattgt gtcatgggtg tttgggttcc tatttcaaat ctggccagtc 480 tatgccacat ttcagcttac cttctgcaaa tcaaatgtga tagaccattt tttatgtgac 540 cgagggcaac tgctcaaact atcctgtgat gatagccttt tcacagagtt tatccttttc 600 ttaatggctg tattcattat tgttggttct atgatcccta caatcatctc ctacacctac 660 atcatctcta ccatcctcaa gatcccctca gccttgggcc ggaggaaagc tttctctact 720 tgtgcctctc acttcacctt tgttgtgatt ggctatggta cctgcttgtt cctctatgtg 780 aaacccaagc aaacgcaggc agctgagtac aacagggtag cgtcactgat ggttttagtg 840 gtgacccctt tcctgaaccc attcatcttc acccttcgga atgacaaatt catagaggcc 900 tttcgagatg tcatgaaacg ctgctatcaa ctcctcaagg attag 945

<210> 2444 <211> 314 <212> PRT

Page 2707

069269_0225_SL.TXT <213> Felis catus <400> 2444

Met 1 Leu Lys Asn Tyr Ser Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe 5 10 15 His Gly Ser Lys Glu Leu His Asp Ile Leu Phe Ala Thr Phe Phe Phe 20 25 30 Leu Tyr Ser Val Thr Val Met Gly Asn Met Val Ile Ile Val Ile Val 35 40 45 Cys Val Asp Lys Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Gly His 50 55 60 Leu Ser Val Leu Glu Ile Leu Ile Thr Ser Val Ala Val Pro Leu Met 65 70 75 80 Leu Trp Gly Leu Leu Leu Pro Gly Met Gln Ala Met Ser Leu Thr Ala 85 90 95 Cys Ser Ala Gln Leu Tyr Leu Tyr Leu Ser Leu Gly Thr Ser Glu Leu 100 105 110 Val Leu Ile Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Asn Ile Ile Met Asp Ser His Thr Cys Ile Trp Val 130 135 140 Val Ile Val Ser Trp Val Phe Gly Phe Leu Phe Gln Ile Trp Pro Val 145 150 155 160 Tyr Ala Thr Phe Gln Leu Thr Phe Cys Lys Ser Asn Val Ile Asp His 165 170 175 Phe Leu Cys Asp Arg Gly Gln Leu Leu Lys Leu Ser Cys Asp Asp Ser 180 185 190 Leu Phe Thr Glu Phe Ile Leu Phe Leu Met Ala Val Phe Ile Ile Val

Page 2708

195 069269_0225_SL.TXT 200 205 Gly Ser Met Ile Pro Thr Ile Ile Ser Tyr Thr Tyr Ile Ile Ser Thr 210 215 220 Ile Leu Lys Ile Pro Ser Ala Leu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Thr Phe Val Val Ile Gly Tyr Gly Thr Cys Leu 245 250 255 Phe Leu Tyr Val Lys Pro Lys Gln Thr Gln Ala Ala Glu Tyr Asn Arg 260 265 270 Val Ala Ser Leu Met Val Leu Val Val Thr Pro Phe Leu Asn Pro Phe 275 280 285 Ile Phe Thr Leu Arg Asn Asp Lys Phe Ile Glu Ala Phe Arg Asp Val 290 295 300 Met Lys Arg Cys Tyr Gln Leu Leu Lys Asp

305 310 <210> 2445 <211> 945 <212> DNA <213> Felis catus <400> 2445

atgttgggga atcactctag tgccactgaa ttttatctcc ttggcttccc tggctcccga 60 gaactacatc atattctctt tgctatcttc ttcttcttct actcagtgac attaatggga 120 aacatggtca tcattgtgat tgtctgtgtg gacagacgtc tgcagtcccc catgtatttc 180 ttccttggtc atctctctgc cttggagatc ttggttacta ctaatatcgt gcccatgatg 240 ctttgggggc tgctgctccc tgggatgcag acaatatctc tggctgcatg tgtcacccag 300 ctcttcctgt acctttcttt ggggaccaca gagtttgcat tactgggagc gatggctgtg 360 gaccgttacg tggctgtctg taaccctctg aggtacgaca tcattatgaa cagccgcacc 420 tgcatctggg tggtcattat gtcatgggtg tttgggttcc tttctgaaat ctggccaatt 480

Page 2709

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tatgccacat ttcagcttac cttctgcaaa tcaaatgtgg tgaacaattt cttctgtgac 540 cgagggcaat tgctcaatct atcctgcaat aatacccttt tcatagagtt tgtcctattc 600 ttaatggctg tttttattct ttttggttct cttatcccta caatcatctc ctacacctat 660 atcatctcca ctatcatcaa gattccctca gtctctggcc ggaggaaagc cttctctact 720 tgtgcatccc acttcacttg tgttgtgatc ggctatggga cctgcttgtt cctctatgtg 780 aaacccaagc aaacgcaggc agctgagtac aacagggtag cgtcactgat ggttttagtg 840 gtgacccctt ttctaaaccc atttatcttc accctacgga atgaaaaatt catagaggtc 900 tttcgagatg tcatgaaacg ctgctctcaa ctcctcaagg gttag 945

<210> 2446 <211> 314 <212> PRT <213> Felis catus <400> 2446

Met 1 Leu Gly Asn His Ser Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe 5 10 15 Pro Gly Ser Arg Glu Leu His His Ile Leu Phe Ala Ile Phe Phe Phe 20 25 30 Phe Tyr Ser Val Thr Leu Met Gly Asn Met Val Ile Ile Val Ile Val 35 40 45 Cys Val Asp Arg Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Gly His 50 55 60 Leu Ser Ala Leu Glu Ile Leu Val Thr Thr Asn Ile Val Pro Met Met 65 70 75 80 Leu Trp Gly Leu Leu Leu Pro Gly Met Gln Thr Ile Ser Leu Ala Ala 85 90 95 Cys Val Thr Gln Leu Phe Leu Tyr Leu Ser Leu Gly Thr Thr Glu Phe 100 105 110

Page 2710

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Ala Leu Leu 115 Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 120 125 Pro Leu Arg Tyr Asp Ile Ile Met Asn Ser Arg Thr Cys Ile Trp Val 130 135 140 Val Ile Met Ser Trp Val Phe Gly Phe Leu Ser Glu Ile Trp Pro Ile 145 150 155 160 Tyr Ala Thr Phe Gln Leu Thr Phe Cys Lys Ser Asn Val Val Asn Asn 165 170 175 Phe Phe Cys Asp Arg Gly Gln Leu Leu Asn Leu Ser Cys Asn Asn Thr 180 185 190 Leu Phe Ile Glu Phe Val Leu Phe Leu Met Ala Val Phe Ile Leu Phe 195 200 205 Gly Ser Leu Ile Pro Thr Ile Ile Ser Tyr Thr Tyr Ile Ile Ser Thr 210 215 220 Ile Ile Lys Ile Pro Ser Val Ser Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Thr Cys Val Val Ile Gly Tyr Gly Thr Cys Leu 245 250 255 Phe Leu Tyr Val Lys Pro Lys Gln Thr Gln Ala Ala Glu Tyr Asn Arg 260 265 270 Val Ala Ser Leu Met Val Leu Val Val Thr Pro Phe Leu Asn Pro Phe 275 280 285 Ile Phe Thr Leu Arg Asn Glu Lys Phe Ile Glu Val Phe Arg Asp Val 290 295 300 Met Lys Arg Cys Ser Gln Leu Leu Lys Gly

305 310

Page 2711

069269_0225_SL.TXT <210> 2447 <211> 945 <212> DNA <213> Felis catus <400> 2447

atgttgggga atcactctag tgccactgaa ttttatctcc ttggcttccc tggctcccga 60 gaactacatc atattctctt tgctatcttc ttcttcttct actcagtgac attaatggga 120 aacatggtca tcattgtgat tgtctgtgtg gacagacgtc tgcagtcccc catgtatttc 180 ttccttggtc atctctctgc cttggagatc ttggttacaa ctattatcgt gcccatgatg 240 ctttgggggc tgctgctccc tgggatgcag acaatatctc tggctgcatg tgtcacccag 300 ctcttcctgt acctttcttt ggggaccaca gagtttgcat tactgggagc gatggctgtg 360 gaccgttacg tggctgtctg taaccctctg aggtacgaca tcattatgaa cagccgcacc 420 tgcatctggg tggtcattat gtcatgggtg tttgggttcc tttttcaaat ctggccagtt 480 tatgccacat ttcagcttac cttctgcaaa tcaaatgtgg tgaacaattt cttctgtgac 540 cgagggcaat tgctcaaact gtcctgcaac aatacccttt ttattgagtt catcctgttc 600 ttaatggctg tttttgttct ttttggttct cttatcccta cagtcatctc gtacagctat 660 atcatctcca caatcctcag gatcccctca gcctctggcc ggaggaaagc cttttctaca 720 tgtgcctctc acttcacatg tgtcgtgatt gggtacggca gttgcttgtt cctctatgtg 780 aaacccaagc aaactcaagc agctgattac aatagggtgg tgtccttgat ggtttcagta 840 gttactcctt tcctcaatcc cttcatcttc accctccgaa atgacaaagt catagaagcc 900 cttcgggacg gagcaaagca ctggtgtcaa ctattcagga attag 945

<210> 2448 <211> 314 <212> PRT <213> Felis catus <400> 2448

Met Leu Gly Asn His Ser Ser Ala Thr Glu Phe Tyr Leu Leu Gly Phe 1 5 10 15 Pro Gly Ser Arg Glu Leu His His Ile Leu Phe Ala Ile Phe Phe Phe 20 25 30

Page 2712

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Phe Tyr Ser 35 Val Thr Leu Met Gly Asn Met Val Ile Ile Val Ile Val 40 45 Cys Val Asp Arg Arg Leu Gln Ser Pro Met Tyr Phe Phe Leu Gly His 50 55 60 Leu Ser Ala Leu Glu Ile Leu Val Thr Thr Ile Ile Val Pro Met Met 65 70 75 80 Leu Trp Gly Leu Leu Leu Pro Gly Met Gln Thr Ile Ser Leu Ala Ala 85 90 95 Cys Val Thr Gln Leu Phe Leu Tyr Leu Ser Leu Gly Thr Thr Glu Phe 100 105 110 Ala Leu Leu Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Asp Ile Ile Met Asn Ser Arg Thr Cys Ile Trp Val 130 135 140 Val Ile Met Ser Trp Val Phe Gly Phe Leu Phe Gln Ile Trp Pro Val 145 150 155 160 Tyr Ala Thr Phe Gln Leu Thr Phe Cys Lys Ser Asn Val Val Asn Asn 165 170 175 Phe Phe Cys Asp Arg Gly Gln Leu Leu Lys Leu Ser Cys Asn Asn Thr 180 185 190 Leu Phe Ile Glu Phe Ile Leu Phe Leu Met Ala Val Phe Val Leu Phe 195 200 205 Gly Ser Leu Ile Pro Thr Val Ile Ser Tyr Ser Tyr Ile Ile Ser Thr 210 215 220 Ile Leu Arg Ile Pro Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240

Page 2713

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Cys Ala Ser His Phe Thr Cys Val Val Ile Gly Tyr Gly Ser Cys Leu 245 250 255 Phe Leu Tyr Val Lys Pro Lys Gln Thr Gln Ala Ala Asp Tyr Asn Arg 260 265 270 Val Val Ser Leu Met Val Ser Val Val Thr Pro Phe Leu Asn Pro Phe 275 280 285 Ile Phe Thr Leu Arg Asn Asp Lys Val Ile Glu Ala Leu Arg Asp Gly 290 295 300 Ala Lys His Trp Cys Gln Leu Phe Arg Asn 305 310

<210> 2449 <211> 917 <212> DNA <213> Felis catus <400> 2449 agtcgacagc agcgtttcat accatcccga agggcctctt tgactttgtc attccgcagg gtgaagatga aagggttcag gaaaggggtt accacagaaa taaacaggga aactatcttg ttgtactcag cagcctgtgt ttgcttaggt tttacaaaca ggaacaagca gcttccatag ccaatcacaa caaagataaa gtgagaggca cacgtagaga aggctttcct ccggcccgag gctgtgggga tcttgaggat ggtagagatg atgtaggtgt aggagactat tgttggggcc agcgaaccaa tgataatgac aacagccatt aagaagagaa caaactctgt gaaaagagtg tcaccacagg atagtttgag cagttgccct cggtcacaga aaaaatggtc taacagattt gacttgcaga aggtaaactg aaatgtggca tagactggcc atatttcaga gaggaaccca aacacccatg acacaatgac cacccagatg caggtgtggc tgttcataat gatgttgtac ctcaaagggt tacagacagc cacgtaacga tccacagcca tcgctcccag taatgcgaac tctgtggtcc ccacagcaag gtacaggaag agctgggtga cacatgcagc cagagatatt gtctgcatcc cagggagcat caatccccaa agcatcacag gcacaataat agttgtaacc aatatctcca aggcagagag atgaccaagg aagaaataca taggggaccg cagacgttta

120

180

240

300

360

420

480

540

600

660

720

780

Page 2714

069269_0225_SL.TXT acgttgctga gtagaagaaa cgggaaagcc tagaaggcag tccacacaga caatcacgat gatgactgtg tttcccatta aagaatatgg caaaaagagt gtggtgtagt tcttgggacc aactcagtgg caccaga

840

900

917 <210> 2450 <211> 306 <212> PRT <213> Felis catus

<400> 2450 Ser Gly Ala 1 Thr Glu Phe Cys 5 Leu Leu Gly Phe Pro Gly Ser Gln Glu 10 15 Leu His His Thr Leu Phe Ala Ile Phe Phe Phe Phe Tyr Ser Ala Thr 20 25 30 Leu Met Gly Asn Thr Val Ile Ile Val Ile Val Cys Val Asp Lys Arg 35 40 45 Leu Arg Ser Pro Met Tyr Phe Phe Leu Gly His Leu Ser Ala Leu Glu 50 55 60 Ile Leu Val Thr Thr Ile Ile Val Pro Val Met Leu Trp Gly Leu Met 65 70 75 80 Leu Pro Gly Met Gln Thr Ile Ser Leu Ala Ala Cys Val Thr Gln Leu 85 90 95 Phe Leu Tyr Leu Ala Val Gly Thr Thr Glu Phe Ala Leu Leu Gly Ala 100 105 110 Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn Pro Leu Arg Tyr Asn 115 120 125 Ile Ile Met Asn Ser His Thr Cys Ile Trp Val Val Ile Val Ser Trp 130 135 140 Val Phe Gly Phe Leu Ser Glu Ile Trp Pro Val Tyr Ala Thr Phe Gln 145 150 155 160

Page 2715

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Phe Thr Phe Cys Lys Ser Asn Leu Leu Asp His Phe Phe Cys Asp Arg 165 170 175 Gly Gln Leu Leu Lys Leu Ser Cys Gly Asp Thr Leu Phe Thr Glu Phe 180 185 190 Val Leu Phe Leu Met Ala Val Val Ile Ile Ile Gly Ser Leu Ala Pro 195 200 205 Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr Ile Leu Lys Ile Pro 210 215 220 Thr Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr Cys Ala Ser His Phe 225 230 235 240 Ile Phe Val Val Ile Gly Tyr Gly Ser Cys Leu Phe Leu Phe Val Lys 245 250 255 Pro Lys Gln Thr Gln Ala Ala Glu Tyr Asn Lys Ile Val Ser Leu Phe 260 265 270 Ile Ser Val Val Thr Pro Phe Leu Asn Pro Phe Ile Phe Thr Leu Arg 275 280 285 Asn Asp Lys Val Lys Glu Ala Leu Arg Asp Gly Met Lys Arg Cys Cys 290 295 300

Arg Leu 305 <210> 2451 <211> 925 <212> DNA <213> Felis catus <400> 2451 agcagcgttt cataccatcc cgaagggcct ctttgacttt gtcattccgc agggtgaaga tgaaagggtt caggaaaggg gttaccacag aaataaacag ggaaactatc ttgttgtact

120

Page 2716

069269_0225_SL.TXT

cagcagcctg tgtttgctta ggtttcacat agaggaacaa gcaactgcca tagccgatca 180 caacaaaggt gaagtgagaa gcacacgtag agaaggcttt cctccggccc gaggctgtgg 240 ggatcttgag gatggtagag atgatgtagg tgtaggagac tattgttggg gtcagtgaac 300 caatgataat gacaacagcc attaagaaga gaacaaactc tgtgaaaaga gtgtcaccac 360 aggatagttt gagcagttgc ccgcgttcac aaaaatagtg gtctaacaga tttgacttgc 420 agaaggtaaa ctgaaatgtg gcatagactg gccatatttc acagaggaac ccaaacaccc 480 atgacacaat gaccacccag atgcaggtgt ggctgttcat aatgatgttg tacctcaaag 540 ggttacagac agccacgtaa cggtccacag ccatcgctcc cagtaacaca aactctgtgg 600 tccccacagc aaggtacagg aagagctggg tgacacatgc agccagagat attgtctgca 660 tcccaggaag cagcaatccc caaagcagca tgggcacagt aatagttgtg atcaggatct 720 ccaaggcaga caaatgacca aggaagaaat acatgggaga ctgcagacgt ttatccacac 780 agacaatcac aatgatgact gtgtttccca ttaatgtcac tgagtagaag aaaaagaata 840 tggcaaaaag aatgtggtgt agttcttggg acccaggaaa gcctagaagg cagaactcag 900 tggcactaga gaaattgttc atcat 925

<210> 2452 <211> 309 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (309)..(309) <223> Any amino acid <400> 2452

Met Met Asn Asn 1 Phe Ser 5 Ser Ala Thr Glu 10 Phe Cys Leu Leu Gly 15 Phe Pro Gly Ser Gln Glu Leu His His Ile Leu Phe Ala Ile Phe Phe Phe 20 25 30 Phe Tyr Ser Val Thr Leu Met Gly Asn Thr Val Ile Ile Val Ile Val

35 40 45

Page 2717

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Cys Val 50 Asp Lys Arg Leu Gln Ser 55 Pro Met Tyr Phe Phe Leu Gly 60 His Leu Ser Ala Leu Glu Ile Leu Ile Thr Thr Ile Thr Val Pro Met Leu 65 70 75 80 Leu Trp Gly Leu Leu Leu Pro Gly Met Gln Thr Ile Ser Leu Ala Ala 85 90 95 Cys Val Thr Gln Leu Phe Leu Tyr Leu Ala Val Gly Thr Thr Glu Phe 100 105 110 Val Leu Leu Gly Ala Met Ala Val Asp Arg Tyr Val Ala Val Cys Asn 115 120 125 Pro Leu Arg Tyr Asn Ile Ile Met Asn Ser His Thr Cys Ile Trp Val 130 135 140 Val Ile Val Ser Trp Val Phe Gly Phe Leu Cys Glu Ile Trp Pro Val 145 150 155 160 Tyr Ala Thr Phe Gln Phe Thr Phe Cys Lys Ser Asn Leu Leu Asp His 165 170 175 Tyr Phe Cys Glu Arg Gly Gln Leu Leu Lys Leu Ser Cys Gly Asp Thr 180 185 190 Leu Phe Thr Glu Phe Val Leu Phe Leu Met Ala Val Val Ile Ile Ile 195 200 205 Gly Ser Leu Thr Pro Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr 210 215 220 Ile Leu Lys Ile Pro Thr Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Thr Phe Val Val Ile Gly Tyr Gly Ser Cys Leu 245 250 255

Page 2718

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Phe Leu Tyr Val 260 Lys Pro Lys Gln Thr Gln Ala Ala Glu Tyr Asn Lys 265 270 Ile Val Ser Leu Phe Ile Ser Val Val Thr Pro Phe Leu Asn Pro Phe 275 280 285 Ile Phe Thr Leu Arg Asn Asp Lys Val Lys Glu Ala Leu Arg Asp Gly 290 295 300 Met Lys Arg Cys Xaa

305 <210> 2453 <211> 966 <212> DNA <213> Felis catus <400> 2453

caggcaccca gctcctggat catgacaaat ctgagccacc tatctgaatt tgtgctcttg 60 ggcttctcct cttttggtga gctgcaagtt ctgctgtgtg ggcctttcct catgctttat 120 cttcttgcct tcctgggaaa cactgtcatc atagtcacag tcatagccaa caccaaccta 180 catactccca tgtacttctt cccgggtaac ttttcactgc tggagacctt ggtgaccata 240 actacagtgc ctaggatgct ttcagacctg ctggtaccct gcaaagtcat ttccttcaat 300 ggctgcatgg cccagttcta cttctacttt tccctgggtt ccacctcctt cctcatcctg 360 tcagacatgg ctcttgaccg ctttgtggcc atctgccatc cactgcgctg tggaactttg 420 atgagctggg atgtgtgtat ccagttggta gggacttcct gggcagctcc tttcttagcc 480 atggtgccca ctgtcttctc ccaggcttat ctcagttatt gccatgacaa catcattaac 540 cacttcttct gtgacaatgc acttctgctg caactgtcct gctcagacac cagcctgcag 600 gaattctggg actttgtgat ggccttagcc tttgtcctca gttccttcct ggtgaccctc 660 atctcctatg gctatattgt gaccactgtg ctgaggatcc cctctgctag cggccatcag 720 aaggctttct caacctgtgg atcccacctc accctggtct tcattggcta caggtctggc 780 accatcttcc ttcatgtcag gtctggcaaa gaacattcta tggaagtcaa caagaccgta 840 gccttggtga catcagtcct cacccccttt ctcaatatct ttatccttac cctctgcaat 900

Page 2719

069269_0225_SL.TXT aagacagtca aggcagtgct acgggggcag atgcagaggc ttaaaggcct ccacaaggct ctatga

960

966 <210> 2454 <211> 314 <212> PRT <213> Felis catus

<400> 2454 Gly Phe 15 Ser Met Thr 1 Asn Leu Ser His 5 Leu Ser Glu Phe 10 Val Leu Leu Ser Phe Gly Glu Leu Gln Val Leu Leu Cys Gly Pro Phe Leu Met Leu 20 25 30 Tyr Leu Leu Ala Phe Leu Gly Asn Thr Val Ile Ile Val Thr Val Ile 35 40 45 Ala Asn Thr Asn Leu His Thr Pro Met Tyr Phe Phe Pro Gly Asn Phe 50 55 60 Ser Leu Leu Glu Thr Leu Val Thr Ile Thr Thr Val Pro Arg Met Leu 65 70 75 80 Ser Asp Leu Leu Val Pro Cys Lys Val Ile Ser Phe Asn Gly Cys Met 85 90 95 Ala Gln Phe Tyr Phe Tyr Phe Ser Leu Gly Ser Thr Ser Phe Leu Ile 100 105 110 Leu Ser Asp Met Ala Leu Asp Arg Phe Val Ala Ile Cys His Pro Leu 115 120 125 Arg Cys Gly Thr Leu Met Ser Trp Asp Val Cys Ile Gln Leu Val Gly 130 135 140 Thr Ser Trp Ala Ala Pro Phe Leu Ala Met Val Pro Thr Val Phe Ser 145 150 155 160

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Gln Ala Tyr Leu Ser Tyr Cys His Asp Asn 170 Ile Ile Asn His Phe 175 Phe 165 Cys Asp Asn Ala Leu Leu Leu Gln Leu Ser Cys Ser Asp Thr Ser Leu 180 185 190 Gln Glu Phe Trp Asp Phe Val Met Ala Leu Ala Phe Val Leu Ser Ser 195 200 205 Phe Leu Val Thr Leu Ile Ser Tyr Gly Tyr Ile Val Thr Thr Val Leu 210 215 220 Arg Ile Pro Ser Ala Ser Gly His Gln Lys Ala Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Leu Val Phe Ile Gly Tyr Arg Ser Gly Thr Ile Phe 245 250 255 Leu His Val Arg Ser Gly Lys Glu His Ser Met Glu Val Asn Lys Thr 260 265 270 Val Ala Leu Val Thr Ser Val Leu Thr Pro Phe Leu Asn Ile Phe Ile 275 280 285 Leu Thr Leu Cys Asn Lys Thr Val Lys Ala Val Leu Arg Gly Gln Met 290 295 300 Gln Arg Leu Lys Gly Leu His Lys Ala Leu 305 310 <210> 2455 <211> 934 <212> DNA <213> Felis catus <400> 2455 gctgctgggt i ctctgaggag gagacttttg gtcatatctc caatgacctc cttgaccttc tcattccgga aggtgaagat gaagggattc aggaaagggg tcaccactac agtcatcaga gccaccactt tgttgaagtg tgtgaagtag cccttgcctg gcctcacata gatgaagatg

120

180

Page 2721

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tcactaccat agcccagaac caccacagtg aggtgggaga cacaggtgga gatggctttc 240 tggtgcccag agaaagaggg gatgtgcagc actgcagcca caatgaggat ataggacact 300 atgatcagca gcatggtggc cagcacgaag agcaaggaca ggaagaaatc catgcactca 360 acgtggcagg cgtcagagca ggaaagcttg agaagtgggg cagagtcaca aaagtggtgg 420 ttgatgacat tagggccacc gaaccagagc cgtgttttct gcaggatcgg ggagatgata 480 gagacaaagc caaccaccca acagactgcc accagcttca tacacactgg gccattcatg 540 atggttgggt agtgcggagg gcggcagatg gccatacagt gatcaaaggc cgtgactgtg 600 agaatcacaa agttggtgga acccaaggag aagtaaaaga gagactggat caggcactca 660 gccagggaaa tggtcttctg agggacagca ggtctgccag catcctagga accacagtgg 720 aggtgaccag catctccatg agggagaagt tacagaggaa gaagtacatg ggtgagtgga 780 ggcaggagtc aaggcatgtg agggtaataa tggccaggtt ctccagcact gtcagcacac 840 atatcaaaag gatgaatgca aacagtagga cctggaactc atggaggtgt gacaatccca 900 gcagtacaaa tcccctaacc acgctgaagt tact 934

<210> 2456 <211> 311 <212> PRT <213> Felis catus <400> 2456

Cys Trp Val Ser Glu Glu Glu Thr Phe Gly His Ile Ser Asn Asp Leu 1 5 10 15 Leu Asp Leu Leu Ile Pro Glu Gly Glu Asp Glu Gly Ile Gln Glu Arg 20 25 30 Gly His His Tyr Ser His Gln Ser His His Phe Val Glu Val Cys Glu 35 40 45 Val Ala Leu Ala Trp Pro His Ile Asp Glu Asp Val Thr Thr Ile Ala 50 55 60 Gln Asn His His Ser Glu Val Gly Asp Thr Gly Gly Asp Gly Phe Leu 65 70 75 80

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Val Pro Arg Glu Arg 85 Gly Asp Val Gln His Cys Ser His Asn Glu Asp 90 95 Ile Gly His Tyr Asp Gln Gln His Gly Gly Gln His Glu Glu Gln Gly 100 105 110 Gln Glu Glu Ile His Ala Leu Asn Val Ala Gly Val Arg Ala Gly Lys 115 120 125 Leu Glu Lys Trp Gly Arg Val Thr Lys Val Val Val Asp Asp Ile Arg 130 135 140 Ala Thr Glu Pro Glu Pro Cys Phe Leu Gln Asp Arg Gly Asp Asp Arg 145 150 155 160 Asp Lys Ala Asn His Pro Thr Asp Cys His Gln Leu His Thr His Trp 165 170 175 Ala Ile His Asp Gly Trp Val Val Arg Arg Ala Ala Asp Gly His Thr 180 185 190 Val Ile Lys Gly Arg Asp Cys Glu Asn His Lys Val Gly Gly Thr Gln 195 200 205 Gly Glu Val Lys Glu Arg Leu Asp Gln Ala Leu Ser Gln Gly Asn Gly 210 215 220 Leu Leu Arg Asp Ser Arg Ser Ala Ser Ile Leu Gly Thr Thr Val Glu 225 230 235 240 Val Thr Ser Ile Ser Met Arg Glu Lys Leu Gln Arg Lys Lys Tyr Met 245 250 255 Gly Glu Trp Arg Gln Glu Ser Arg His Val Arg Val Ile Met Ala Arg 260 265 270 Phe Ser Ser Thr Val Ser Thr His Ile Lys Arg Met Asn Ala Asn Ser 275 280 285

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Arg Thr Trp Asn Ser Trp Arg Cys Asp Asn Pro Ser Ser Thr Asn Pro 290 295 300

Leu Thr Thr Leu Lys Leu Leu

305 310 <210> 2457 <211> 942 <212> DNA <213> Felis catus <400> 2457 ctaaagtttt gattcagaac tcctcatcag aactcgactc agagcagctt tcatctcgtt 60 gttccgtaga ctgtagatga gcggattcaa catgggggtc atcacagcat aaaagagcgt 120 caccaccttg tcctgcttgg ctgaagctgt ggagtggggc tgcatgtagg tgaccagggc 180 catcccgtaa gacatggaga ccacggtgag gtgggaggca caggtcccga aggccttgcg 240 gcgtccccca gtggagcgga tccgcaggat ggctgccacg atgtaggtat aggacagtga 300 gacgaggcag catggcacca gcagcaccac cacgctggag gccagtatga ccacctggtt 360 gagggtgatg tccacgcagg ccaggcggac gagtgccagc gtctcacagg ccacatggtt 420 cagcacatgg tgcccacagg taggcagacg catggtgacc accgtctcca ctgtagaatt 480 caccaggcct acaagccaag agacagctgc caggcctgtg cagcacctcg ggctcatcac 540 tgccacgtag cgcagggggt cacagacagc cacgtagcgg tcataggcca tagcggccag 600 cagcaggaac tcggtacccc ccagggccag tgagaagaag agctgagtcc cacatcgggt 660 gaaggagatg gtcttcttct ccaggaggaa gtgcaccagc atctggggga ccccactaga 720 ggtgtagcag atgtccacca ctgagaggtt gcagaggaag aagtacatgg gcaggtgcag 780 ccgtgcatcc agcccgatca ggaggataat gagcccgttg cccagcaggg tcagcagata 840 ggcggccgca aacaggacaa agagtccagc ctgggtctgc ctgtcgctgg agagccccag 900 gaggacaaac tcactttccc aggtcaggtt gtccctcctc at 942 <210> 2458 <211> 313 <212> PRT <213> Felis catus

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<400> 2458 Asn Leu Thr Trp Glu Ser Glu Phe Val Leu Leu 15 Gly Met 1 Arg Arg Asp 5 10 Leu Ser Ser Asp Arg Gln Thr Gln Ala Gly Leu Phe Val Leu Phe Ala 20 25 30 Ala Ala Tyr Leu Leu Thr Leu Leu Gly Asn Gly Leu Ile Ile Leu Leu 35 40 45 Ile Gly Leu Asp Ala Arg Leu His Leu Pro Met Tyr Phe Phe Leu Cys 50 55 60 Asn Leu Ser Val Val Asp Ile Cys Tyr Thr Ser Ser Gly Val Pro Gln 65 70 75 80 Met Leu Val His Phe Leu Leu Glu Lys Lys Thr Ile Ser Phe Thr Arg 85 90 95 Cys Gly Thr Gln Leu Phe Phe Ser Leu Ala Leu Gly Gly Thr Glu Phe 100 105 110 Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asp 115 120 125 Pro Leu Arg Tyr Val Ala Val Met Ser Pro Arg Cys Cys Thr Gly Leu 130 135 140 Ala Ala Val Ser Trp Leu Val Gly Leu Val Asn Ser Thr Val Glu Thr 145 150 155 160 Val Val Thr Met Arg Leu Pro Thr Cys Gly His His Val Leu Asn His 165 170 175 Val Ala Cys Glu Thr Leu Ala Leu Val Arg Leu Ala Cys Val Asp Ile 180 185 190 Thr Leu Asn Gln Val Val Ile Leu Ala Ser Ser Val Val Val Leu Leu 195 200 205

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Val Pro Cys Cys Leu Val Ser 215 Leu Ser Tyr Thr Tyr 220 Ile Val Ala Ala 210 Ile Leu Arg Ile Arg Ser Thr Gly Gly Arg Arg Lys Ala Phe Gly Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ser Met Ser Tyr Gly Met Ala Leu 245 250 255 Val Thr Tyr Met Gln Pro His Ser Thr Ala Ser Ala Lys Gln Asp Lys 260 265 270 Val Val Thr Leu Phe Tyr Ala Val Met Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Asn Glu Met Lys Ala Ala Leu Ser Arg Val 290 295 300 Leu Met Arg Ser Ser Glu Ser Lys Leu 305 310

<210> 2459 <211> 966 <212> DNA <213> Felis catus <400> 2459

tcagggctca cacagacctt gtccctgccg cccctgcccc agcacccggc ggatggcggt 60 ggtgatctcg cggttgcgca ggctgtagat gagcgggtac agcagcggcg tgatgttggt 120 gtagatgagt gccagcgtgc ggtcccgccg tggggagtag ctggccttgg gccgcacata 180 catgaaggtg gcacagccat agtgcaggaa agtgacggcc aggtgcgagg cgcaggtgga 240 ggcagccttg taccggcccc tgggggagtg caggcgacgc agggtggcgg cgatggctcc 300 gtaggaggac aggatgagca gtgagggcag cagcagcagc acgaggcagg tgcccagcag 360 gggaagctca tcggcgtagc tccgtgtgca agccaggtcc agcagcgccg tgatgtcgca 420 gaagaaatgc accagtagac gggagccgca gaaaggcagg tgaaagatgg ccactgtgag 480

Page 2726

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ccccacggac actgccagtc ccccgagaca gcaggccagg gccagccttg cgcacagccc 540 tggggtcacc actgcggtgt agcgcagcgg gtggcagatg gccacgtaac ggtcataggc 600 catggtggcc agcaggaagc actcggcccc acccagcgcc acgaacatct gcatctgaac 660 tgcgcagccc aggaaggaga tggggctgcc cccgccaagg cctggcgtgg ccaggtcagc 720 cagggagcgg ggcaccacca ccagagtgta acagagctcg atggctgaca gctggcacag 780 gaagagcagc atgggtggtg ggctgggcac tgaggccacg gccaccagga tgagcaggtt 840 cccgcccagg gtggccaggt gcacagctag cagcaacaag aagagcaccg gccttaggtg 900 cgggaactca gagaagccct gaaggagaaa gccacagggc atggtggcat tgctggggct 960

gtccat 966 <210> 2460 <211> 321 <212> PRT <213> Felis catus <400> 2460

Met Asp Ser Pro Ser Asn Ala Thr Met Pro Cys Gly Phe Leu Leu Gln 1 5 10 15 Gly Phe Ser Glu Phe Pro His Leu Arg Pro Val Leu Phe Leu Leu Leu 20 25 30 Leu Ala Val His Leu Ala Thr Leu Gly Gly Asn Leu Leu Ile Leu Val 35 40 45 Ala Val Ala Ser Val Pro Ser Pro Pro Pro Met Leu Leu Phe Leu Cys 50 55 60 Gln Leu Ser Ala Ile Glu Leu Cys Tyr Thr Leu Val Val Val Pro Arg 65 70 75 80 Ser Leu Ala Asp Leu Ala Thr Pro Gly Leu Gly Gly Gly Ser Pro Ile 85 90 95 Ser Phe Leu Gly Cys Ala Val Gln Met Gln Met Phe Val Ala Leu Gly 100 105 110

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Gly Ala Glu 115 Cys Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val 120 125 Ala Ile Cys His Pro Leu Arg Tyr Thr Ala Val Val Thr Pro Gly Leu 130 135 140 Cys Ala Arg Leu Ala Leu Ala Cys Cys Leu Gly Gly Leu Ala Val Ser 145 150 155 160 Val Gly Leu Thr Val Ala Ile Phe His Leu Pro Phe Cys Gly Ser Arg 165 170 175 Leu Leu Val His Phe Phe Cys Asp Ile Thr Ala Leu Leu Asp Leu Ala 180 185 190 Cys Thr Arg Ser Tyr Ala Asp Glu Leu Pro Leu Leu Gly Thr Cys Leu 195 200 205 Val Leu Leu Leu Leu Pro Ser Leu Leu Ile Leu Ser Ser Tyr Gly Ala 210 215 220 Ile Ala Ala Thr Leu Arg Arg Leu His Ser Pro Arg Gly Arg Tyr Lys 225 230 235 240 Ala Ala Ser Thr Cys Ala Ser His Leu Ala Val Thr Phe Leu His Tyr 245 250 255 Gly Cys Ala Thr Phe Met Tyr Val Arg Pro Lys Ala Ser Tyr Ser Pro 260 265 270 Arg Arg Asp Arg Thr Leu Ala Leu Ile Tyr Thr Asn Ile Thr Pro Leu 275 280 285 Leu Tyr Pro Leu Ile Tyr Ser Leu Arg Asn Arg Glu Ile Thr Thr Ala 290 295 300 Ile Arg Arg Val Leu Gly Gln Gly Arg Gln Gly Gln Gly Leu Cys Glu 305 310 315 320

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Pro <210> 2461 <211> 954 <212> DNA <213> Felis catus <400> 2461 atggacacag ataaccagac gtgggtgaaa gagttcattc tccttggtct gtccagtgac 60 tgggaaacac aggtctcact ctttgtcctc ttcttgatca tgtacttggt gacagtgctg 120 gggaacttcc tcattgtcct tctgatcaga ctggacagcc gactccacac tcccatgtac 180 ttctttctca ccaacctctc ccttgttgat gtctcttatg ccacaagtat tgttcctcag 240 atgctggcac atcttcttgc agaacataaa gcaatcccat ttgtgagctg tgcagcccag 300 ttatttttct ccttgggctt gggtgggatt gagtttgttc tactggcagt gatggcctac 360 gaccgctatg tggctgtgtg cgaccccctg cgatactcgg tcatcatgca tggagggctc 420 tgtactaggt tggccatcat atcgtgggtc agtggttctc tcaactctct catgcagacc 480 atcatcacct ttcagctgcc catgtgcaca aacaagtata ttgatcacat atcctgtgaa 540 atcctagctg tggtcagact ggcctgtgtg gacacctcct ccaatgagat cgcgatcatg 600 gtttctagca ttgtcttgct gatgacaccc ttctgcctgg tcctcttgtc ttacactcag 660 atcatctcca ccatcctgaa gatccagtcc acagagggaa gaaagaaagc cttccacacc 720 tgtgcgtctc acctcacagt ggtcgtcttg tgctatggca tgaccatttt cacctacatc 780 cagccccact ccagcccttc tatccttcag gagaagttga tttctgtctt ctatgccatt 840 ctgatgcccg tgctgaaccc catgatttat agcataagga ataaggaggt gaagggtgcc 900 tggcagaaac tactagggca gttatctgga ttaacatcaa aactggcaac ttga 954 <210> 2462 <211> 317 <212> PRT <213> Felis catus <400> 2462

Met Asp Thr Asp Asn Gln Thr Trp Val Lys Glu Phe Ile Leu Leu Gly 1 5 10 15

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Leu Ser Ser Asp 20 Trp Glu Thr Gln Val Ser Leu Phe Val Leu Phe Leu 25 30 Ile Met Tyr Leu Val Thr Val Leu Gly Asn Phe Leu Ile Val Leu Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Leu Val Asp Val Ser Tyr Ala Thr Ser Ile Val Pro Gln 65 70 75 80 Met Leu Ala His Leu Leu Ala Glu His Lys Ala Ile Pro Phe Val Ser 85 90 95 Cys Ala Ala Gln Leu Phe Phe Ser Leu Gly Leu Gly Gly Ile Glu Phe 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asp 115 120 125 Pro Leu Arg Tyr Ser Val Ile Met His Gly Gly Leu Cys Thr Arg Leu 130 135 140 Ala Ile Ile Ser Trp Val Ser Gly Ser Leu Asn Ser Leu Met Gln Thr 145 150 155 160 Ile Ile Thr Phe Gln Leu Pro Met Cys Thr Asn Lys Tyr Ile Asp His 165 170 175 Ile Ser Cys Glu Ile Leu Ala Val Val Arg Leu Ala Cys Val Asp Thr 180 185 190 Ser Ser Asn Glu Ile Ala Ile Met Val Ser Ser Ile Val Leu Leu Met 195 200 205 Thr Pro Phe Cys Leu Val Leu Leu Ser Tyr Thr Gln Ile Ile Ser Thr 210 215 220

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Ile 225 Leu Lys Ile Gln Ser Thr Glu Gly Arg Lys Lys Ala Phe His Thr 240 230 235 Cys Ala Ser His Leu Thr Val Val Val Leu Cys Tyr Gly Met Thr Ile 245 250 255 Phe Thr Tyr Ile Gln Pro His Ser Ser Pro Ser Ile Leu Gln Glu Lys 260 265 270 Leu Ile Ser Val Phe Tyr Ala Ile Leu Met Pro Val Leu Asn Pro Met 275 280 285 Ile Tyr Ser Ile Arg Asn Lys Glu Val Lys Gly Ala Trp Gln Lys Leu 290 295 300 Leu Gly Gln Leu Ser Gly Leu Thr Ser Lys Leu Ala Thr 305 310 315

<210> 2463 <211> 954 <212> DNA <213> Felis catus <400> 2463

atgggaacgg gtaaccagac ttatgtgaaa gagttcatac tccttggcct gtccagtgac 60 tgggacacac gggtctccct ctttgtcctc ttcttgatca tatatatggt gacagtgctg 120 gggaactttt tcattgttct tctgatcaga ctggacagcc gactccacac tcccatgtac 180 ttctttctca ccaacctctc ccttgttgat gtctgttatg ccacaagcat cgtcccccag 240 atgttggtgc atcttctaat agaacataaa gcaatcccat ttgtgagctg tgcagcccag 300 ttatttttct ccttgggctt gggtgggatt gagtttgttc tactggcagt gatggcctac 360 gaccgctatg tggctgtgtg cgaccccctg cgatactcgg tcatcatgca tggagggctc 420 tgtaccaggt tggccatcac atcctgggtc agtggttctc tcaactctct catgcagacc 480 atcatcacct ttcagctgcc catgtgcaca aacaagtata ttgatcacat atcctgtgaa 540 ctcctagctg tggtcagact ggcctgtgtg gacatctcct ccaatgagat cgcgatcatg 600

Page 2731

069269_0225_SL.TXT gtttctagca ttgtcttgct gatgacaccc ttctgcctgg tcctcttgtc ctacatccag atcatctcca ccatcctgaa gatccagtcc acagagggaa gaaagaaagc cttccacacc tgtgcgtctc acctcacagt ggtcgtcttg tgctatggca tggccatttt cacttacatc cagccccgct ccagcccctc tattcttcag gagaagttga tctctctctt ctatgccgtt ttgacaccca tgttgaaccc tatgatttat agtgtaagga ataaggaggt gaagggggcc tggcagaaac tactagggca gttatctgga ttaacgtcaa aactggcaac ttga

660

720

780

840

900

954 <210> 2464 <211> 317 <212> PRT <213> Felis catus

<400> 2464 Gln Thr Tyr Val Lys Glu Phe Ile Leu Leu Gly Met 1 Gly Thr Gly Asn 5 10 15 Leu Ser Ser Asp Trp Asp Thr Arg Val Ser Leu Phe Val Leu Phe Leu 20 25 30 Ile Ile Tyr Met Val Thr Val Leu Gly Asn Phe Phe Ile Val Leu Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Leu Val Asp Val Cys Tyr Ala Thr Ser Ile Val Pro Gln 65 70 75 80 Met Leu Val His Leu Leu Ile Glu His Lys Ala Ile Pro Phe Val Ser 85 90 95 Cys Ala Ala Gln Leu Phe Phe Ser Leu Gly Leu Gly Gly Ile Glu Phe 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asp 115 120 125

Pro Leu Arg Tyr Ser Val Ile Met His Gly Gly Leu Cys Thr Arg Leu Page 2732

130 135 069269_0225_SL.TXT 140 Ala Ile Thr Ser Trp Val Ser Gly Ser Leu Asn Ser Leu Met Gln Thr 145 150 155 160 Ile Ile Thr Phe Gln Leu Pro Met Cys Thr Asn Lys Tyr Ile Asp His 165 170 175 Ile Ser Cys Glu Leu Leu Ala Val Val Arg Leu Ala Cys Val Asp Ile 180 185 190 Ser Ser Asn Glu Ile Ala Ile Met Val Ser Ser Ile Val Leu Leu Met 195 200 205 Thr Pro Phe Cys Leu Val Leu Leu Ser Tyr Ile Gln Ile Ile Ser Thr 210 215 220 Ile Leu Lys Ile Gln Ser Thr Glu Gly Arg Lys Lys Ala Phe His Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Val Leu Cys Tyr Gly Met Ala Ile 245 250 255 Phe Thr Tyr Ile Gln Pro Arg Ser Ser Pro Ser Ile Leu Gln Glu Lys 260 265 270 Leu Ile Ser Leu Phe Tyr Ala Val Leu Thr Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Val Arg Asn Lys Glu Val Lys Gly Ala Trp Gln Lys Leu 290 295 300 Leu Gly Gln Leu Ser Gly Leu Thr Ser Lys Leu Ala Thr 305 310 315

<210> 2465 <211> 954 <212> DNA <213> Felis catus

Page 2733

069269_0225_SL.TXT <400> 2465 atggaaacag ataaccagac atgggtgaga gaatttattc tcctcggcct gtccagtgac 60 ttgtatgtgc aggtctttct ctttgtttta ttcttagtca tgtacttggt gacagtgctg 120 ggaaacttcc ttattgttgc tctgatctgc ctggacagca gactccacac tcccatgtac 180 ttctttctca ccaacctctc ccttgttgat gtctcttatg ccacaagcat cattcctcag 240 atgttagtgc atcttcttgc agaacataaa gcaatcccat ttgtgagctg tgcagcccag 300 ttatttttct ctctaggctg gggtgggatt gagtttgttc tactggcagt gatggcctac 360 gaccgctatg tggctgtgtg cgaccccctg cgatactcgg tcatcatgca tggagggctc 420 tgtactaggt tggccatcac atcctgggtc agtggttccc tcaactctct cattcatact 480 gccatcacct ttcagctgcc catgtgcgca aacaagtata ttgatcacat atcatgtgaa 540 atcctagctg tggtcagact ggcctgtgtg gacacctcct ccaatgagat cataatcatg 600 gtttctagca tcgttctcct gatgacaccc ttctgcctgg tcctcttgtc ctacatccag 660 atcatctcca ccatcctgaa gatccagtcc acagagggaa gaaagaaagc cttccacacc 720 tgtgcgtctc acctcacagt ggtcgtcttg tgctatggca tggccatttt cacttacatc 780 cagccccgct ccagcccctc tattcttcag gagaagttga tctctctctt ctatgccgtt 840 ttgacaccca tgttgaaccc tatgatttat agtgtaagga ataaggaggt gaagggggcc 900 tggcagaaac tactagggca gttatctgga ttaacatcaa aactggcaac ttga 954 <210> 2466 <211> 317 <212> PRT <213> Felis catus <400> 2466

Met Glu Thr Asp Asn Gln Thr Trp Val Arg Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Ser Asp Leu Tyr Val Gln Val Phe Leu Phe Val Leu Phe Leu 20 25 30 Val Met Tyr Leu Val Thr Val Leu Gly Asn Phe Leu Ile Val Ala Leu

35 40 45

Page 2734

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Ile Cys Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Leu Val Asp Val Ser Tyr Ala Thr Ser Ile Ile Pro Gln 65 70 75 80 Met Leu Val His Leu Leu Ala Glu His Lys Ala Ile Pro Phe Val Ser 85 90 95 Cys Ala Ala Gln Leu Phe Phe Ser Leu Gly Trp Gly Gly Ile Glu Phe 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Asp 115 120 125 Pro Leu Arg Tyr Ser Val Ile Met His Gly Gly Leu Cys Thr Arg Leu 130 135 140 Ala Ile Thr Ser Trp Val Ser Gly Ser Leu Asn Ser Leu Ile His Thr 145 150 155 160 Ala Ile Thr Phe Gln Leu Pro Met Cys Ala Asn Lys Tyr Ile Asp His 165 170 175 Ile Ser Cys Glu Ile Leu Ala Val Val Arg Leu Ala Cys Val Asp Thr 180 185 190 Ser Ser Asn Glu Ile Ile Ile Met Val Ser Ser Ile Val Leu Leu Met 195 200 205 Thr Pro Phe Cys Leu Val Leu Leu Ser Tyr Ile Gln Ile Ile Ser Thr 210 215 220 Ile Leu Lys Ile Gln Ser Thr Glu Gly Arg Lys Lys Ala Phe His Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Val Leu Cys Tyr Gly Met Ala Ile 245 250 255

Page 2735

Phe Thr Tyr Ile 260 Gln Pro Arg 069269_0225_SL.TXT Ser Ser Pro Ser Ile Leu 265 Gln 270 Glu Lys Leu Ile Ser Leu Phe Tyr Ala Val Leu Thr Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Val Arg Asn Lys Glu Val Lys Gly Ala Trp Gln Lys Leu 290 295 300 Leu Gly Gln Leu Ser Gly Leu Thr Ser Lys Leu Ala Thr 305 310 315

<210> 2467 <211> 934 <212> DNA <213> Felis catus <400> 2467

atgggcaggg aaaaccagac ctggatgagt gagttcattc tgctggggct gtccagatgc 60 tggaacactc aggtctccct cttcgtcctt ttcctggtca tgtatctggt gactgtgctg 120 gggaacttcc tcatcatcct ccttatcaga ctggacagca ggctacacac acctatgtac 180 tttttcctca gtgtcctgtc atttgtggac atctgttata ccaacagcac cgtcccacag 240 atgcttgttc acttcctgtc agcccggaag tccatcccgt tccacagctg tgtgctccag 300 ctgtttatct ccctggccat gggcagctcc gagtttttcc tgctgggagc catggcctat 360 gaccgctatg tggccgtgtg ccacccgctg cactacacag ccatcatgca tggggggctt 420 tgcctggcgc tggctactgg ctgcttgggg gctggcttca tgaattcact gatgcaggca 480 gtgatcatct tccagctacc tttgtgccat aatgtcatta atcactttgc ctgtgagatg 540 ttggctgtgc tgaggctgac ctgtgtggac atctccttca acaaggtcat ggtggccatc 600 tcaggatttt tggtgatcat gcttccctgt ttcctggttc tgttctccta tgctcgtata 660 gttgctgcta ttctgcatat ccgctccgcc caaggacgct gcaaagcatt tgagacctgt 720 gcttcccacc tcactgtggt ttccatgtgc tttggaacag ccatcttcac atacttgaga 780 ccctctgctg gctcctcagc agagcaagag aagatggtcg ctctgttcta cgctgtggtg 840 accccgatgc taaatccctt aatctacagc ttgaggaaca aggaggtaat gagcgcccta 900

Page 2736

934

069269_0225_SL.TXT agaagactgt tgggaaaatt aagtgaaaaa aggt <210> 2468 <211> 312 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (312)..(312) <223> Any amino acid <400> 2468

Met Gly Arg Glu Asn Gln Thr Trp Met Ser Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Arg Cys Trp Asn Thr Gln Val Ser Leu Phe Val Leu Phe Leu 20 25 30 Val Met Tyr Leu Val Thr Val Leu Gly Asn Phe Leu Ile Ile Leu Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Val Leu Ser Phe Val Asp Ile Cys Tyr Thr Asn Ser Thr Val Pro Gln 65 70 75 80 Met Leu Val His Phe Leu Ser Ala Arg Lys Ser Ile Pro Phe His Ser 85 90 95 Cys Val Leu Gln Leu Phe Ile Ser Leu Ala Met Gly Ser Ser Glu Phe 100 105 110 Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Tyr Val Ala Val Cys His 115 120 125 Pro Leu His Tyr Thr Ala Ile Met His Gly Gly Leu Cys Leu Ala Leu 130 135 140 Ala Thr Gly Cys Leu Gly Ala Gly Phe Met Asn Ser Leu Met Gln Ala

Page 2737

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145 150 His 170 155 160 Val Ile Ile Phe Gln 165 Leu Pro Leu Cys Asn Val Ile Asn His 175 Phe Ala Cys Glu Met Leu Ala Val Leu Arg Leu Thr Cys Val Asp Ile Ser 180 185 190 Phe Asn Lys Val Met Val Ala Ile Ser Gly Phe Leu Val Ile Met Leu 195 200 205 Pro Cys Phe Leu Val Leu Phe Ser Tyr Ala Arg Ile Val Ala Ala Ile 210 215 220 Leu His Ile Arg Ser Ala Gln Gly Arg Cys Lys Ala Phe Glu Thr Cys 225 230 235 240 Ala Ser His Leu Thr Val Val Ser Met Cys Phe Gly Thr Ala Ile Phe 245 250 255 Thr Tyr Leu Arg Pro Ser Ala Gly Ser Ser Ala Glu Gln Glu Lys Met 260 265 270 Val Ala Leu Phe Tyr Ala Val Val Thr Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Met Ser Ala Leu Arg Arg Leu Leu 290 295 300 Gly Lys Leu Ser Glu Lys Arg Xaa

305 310 <210> 2469 <211> 942 <212> DNA

<213> Felis catus <400> 2469 atgggccagg aaaataaaac ccagacatgg gtgagggagt tcattctact agggttgtcc agtgactgga agatgcaagt cttcctcttt gtcctggtcc tgaccatgta cttggtgact

120

Page 2738

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ctggtgggaa atattctcat tcttcttctg atcagactgg acagcaggct tcataacccc 180 atgtacttct tccttagtgt tttatccttt gtggaccttt gttattcaaa cagtattgcc 240 ccacaaatgc tggcccacct gctctcagcc cggaagtcca tcccattcta cagctgtgtg 300 ctccagctct acatctccct ggccctgggt gggtctgagt tcttcctgct gggagccatg 360 gcctatgacc gctatgtggc tgtgtgccac ccactacact acacagtcat catgcatgga 420 cagctgtgtc tggggctggc tgctggctgc ttggtggttg gttttgccaa ttcactgatg 480 gagacaatca ttaccttctg gcttcctctg tgtcacaatg ttattaatca ctttgcctgt 540 gagaccttag cagtgctacg gctagcctgt gtggacatct ccttcaacaa ggtcatggtg 600 gccatctcag gatttctggt gatcatgctt ccctgtttcc tggttctgtt ctcctatgtt 660 cgtatagttg ctgccattct gaatattcgt tctgctcagg gacgtagcaa agcctttggg 720 acgtgtgcct cccacctcac tgtggtttgt atgtgctttg gggctaccat cttcacctac 780 ctggggccac agtcagcctc ctcagaggaa gaggagaaga cggttgctct attctatgct 840 ctggtggcac ctatgctgaa ccccatgatc tatagcttga ggaataagga agttatggct 900 gctctccaaa aggttctaga gaaattctga gataaagagt aa 942

<210> 2470 <211> 309 <212> PRT <213> Felis catus <400> 2470

Met Gly Gln Glu Asn Lys Thr Gln Thr Trp Val Arg Glu Phe Ile Leu 1 5 10 15 Leu Gly Leu Ser Ser Asp Trp Lys Met Gln Val Phe Leu Phe Val Leu 20 25 30 Val Leu Thr Met Tyr Leu Val Thr Leu Val Gly Asn Ile Leu Ile Leu 35 40 45 Leu Leu Ile Arg Leu Asp Ser Arg Leu His Asn Pro Met Tyr Phe Phe 50 55 60

Page 2739

069269_0225_SL.TXT

Leu 65 Ser Val Leu Ser Phe Val Asp Leu Cys Tyr Ser Asn Ser Ile Ala 70 75 80 Pro Gln Met Leu Ala His Leu Leu Ser Ala Arg Lys Ser Ile Pro Phe 85 90 95 Tyr Ser Cys Val Leu Gln Leu Tyr Ile Ser Leu Ala Leu Gly Gly Ser 100 105 110 Glu Phe Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Tyr Val Ala Val 115 120 125 Cys His Pro Leu His Tyr Thr Val Ile Met His Gly Gln Leu Cys Leu 130 135 140 Gly Leu Ala Ala Gly Cys Leu Val Val Gly Phe Ala Asn Ser Leu Met 145 150 155 160 Glu Thr Ile Ile Thr Phe Trp Leu Pro Leu Cys His Asn Val Ile Asn 165 170 175 His Phe Ala Cys Glu Thr Leu Ala Val Leu Arg Leu Ala Cys Val Asp 180 185 190 Ile Ser Phe Asn Lys Val Met Val Ala Ile Ser Gly Phe Leu Val Ile 195 200 205 Met Leu Pro Cys Phe Leu Val Leu Phe Ser Tyr Val Arg Ile Val Ala 210 215 220 Ala Ile Leu Asn Ile Arg Ser Ala Gln Gly Arg Ser Lys Ala Phe Gly 225 230 235 240 Thr Cys Ala Ser His Leu Thr Val Val Cys Met Cys Phe Gly Ala Thr 245 250 255 Ile Phe Thr Tyr Leu Gly Pro Gln Ser Ala Ser Ser Glu Glu Glu Glu 260 265 270

Page 2740

069269_0225_SL.TXT

Lys Thr Val Ala Leu Phe Tyr Ala Leu Val Ala Pro Met Leu Asn Pro 275 280 285

Met Ile Tyr Ser Leu Arg Asn Lys Glu Val Met Ala Ala Leu Gln Lys 290 295 300

Val Leu Glu Lys Phe

305 <210> 2471 <211> 924 <212> DNA <213> Felis catus <400> 2471

atggaagtgg agaaccagac tcaggtcacc aagttcattc ttgtgggatt ccctgggagc 60 tgggccatgc gagtagcagt gttcctgatg ttcctcatcg cctatgctct gacagtggct 120 gaaaatatgg tcatcatctt gttggtgcaa cagaaccggc cactgcacaa gcctatgtac 180 ttcttcctgg ccaacctgtc tttcctggag acctggtaca tctccgtgac ggtacctaag 240 ttgctattta gtttttggtc tgtgagcaat agtatctcct tcactcactg catgatacaa 300 ctgtacttct tcattgcgct catgtgcaca gaatgtgtgc tccttgcggc catggcctat 360 gaccgttatg tggccatctg ccgtccactc cactacccca cgattatgag ccataggctc 420 tgcttccact tggctcttgg ctcctgggcc attggctttg gcatctcctt ggctaagatc 480 tacttcatct cccgcctcag tttctgtggc cccaatgtca tcaatcactt cttctgtgac 540 atctctccag ttcttaacct ctcctgcaca gacatgtctg tagctgagct ggtggacttt 600 gtcctggcac tggtcatctt tctcatcccc ctctctatca ccgtcctgtc ctatggatgc 660 atcctagtta ccgttgtacg catgcccacc ggaaagcaga aagcattctc tacctgtgcc 720 tcccacctcg tggtggtaac catcttttat tcggccacta ttttcatgta tgccaggccc 780 cgagccatcc atgccttcaa catgaacaaa gtaatttcca tcttctatgc cattgtcacc 840 cctgctctca accctttcat ttattgccta aggaacagag aggtcaaaga ggctctgaag 900 aaactggcct attgccaagc tatc 924

<210> 2472

Page 2741

069269_0225_SL.TXT <211> 308 <212> PRT <213> Felis catus

<400> 2472 Ile Leu Val 15 Gly Met 1 Glu Val Glu Asn Gln Thr Gln 5 Val Thr 10 Lys Phe Phe Pro Gly Ser Trp Ala Met Arg Val Ala Val Phe Leu Met Phe Leu 20 25 30 Ile Ala Tyr Ala Leu Thr Val Ala Glu Asn Met Val Ile Ile Leu Leu 35 40 45 Val Gln Gln Asn Arg Pro Leu His Lys Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Leu Glu Thr Trp Tyr Ile Ser Val Thr Val Pro Lys 65 70 75 80 Leu Leu Phe Ser Phe Trp Ser Val Ser Asn Ser Ile Ser Phe Thr His 85 90 95 Cys Met Ile Gln Leu Tyr Phe Phe Ile Ala Leu Met Cys Thr Glu Cys 100 105 110 Val Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Pro Thr Ile Met Ser His Arg Leu Cys Phe His Leu 130 135 140 Ala Leu Gly Ser Trp Ala Ile Gly Phe Gly Ile Ser Leu Ala Lys Ile 145 150 155 160 Tyr Phe Ile Ser Arg Leu Ser Phe Cys Gly Pro Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Val Leu Asn Leu Ser Cys Thr Asp Met 180 185 190

Page 2742

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Ser Val Ala Glu Leu Val Asp Phe 195 200 Ile Pro 210 Leu Ser Ile Thr Val 215 Leu Val 225 Val Arg Met Pro Thr 230 Gly Lys Ser His Leu Val Val 245 Val Thr Ile Tyr Ala Arg Pro 260 Arg Ala Ile His Ser Ile Phe 275 Tyr Ala Ile Val Thr 280 Cys Leu 290 Arg Asn Arg Glu Val 295 Lys Cys Gln Ala Ile

305

Val Leu Ala Leu Val 205 Ile Phe Leu Ser Tyr Gly Cys 220 Ile Leu Val Thr Gln Lys Ala 235 Phe Ser Thr Cys Ala 240 Phe Tyr 250 Ser Ala Thr Ile Phe 255 Met Ala 265 Phe Asn Met Asn Lys 270 Val Ile Pro Ala Leu Asn Pro 285 Phe Ile Tyr Glu Ala Leu Lys 300 Lys Leu Ala Tyr

<210> 2473 <211> 933 <212> DNA <213> Felis catus <400> 2473 atgacagaaa atcaaacatg ggtcacagaa ctgactcagg tgttcctctt tgggctcttc aacagcacca tcctggggct catctggctg tttctctccc acctggctgt tgttgacata ctggcgaacc ttctgaacaa ggaaaaaacg tttttataca tggcttttgc tcacactgag cgatatgtgg cgatttgcca ccccctacgt ttcattctcc tgggattccc actcagccca tccctgttct atgccttcac cctgctgggg gattcccgac tgcacacccc catgtacttc gcctatgcct caaataatgt cccaaagatg atctcctttg tcccatgcat aatgcagacc tgtctcatct tagtaatgat gtcttatgat tacactgtca tcatgaactg gagagtatgc

120

180

240

300

360

420

Page 2743

069269_0225_SL.TXT

acggttcagg ctgtcatttc ctgggcatgc ggctccctgc tggccctggt ccatgtggtt 480 ctcatcctga ggctgccctt ctgcgggcct catgaaatca accacttctt ctgtgagatc 540 ctgtctgtcc tcaagctggc ctgcgctgac acctggctca accaagttgt catttttgct 600 gcttctgtgt ttatcttagt cgggcccctc tgcctggtgc tggtgtccta cacgcgcatc 660 ctgttcgcca tcctgaggat ccagtccggg gagggacgca gaaaggcctt ctccacctgc 720 tcctcccacc tctgcgtggt ggggctcttc tttggaagcg ccattgtcat gtacatggcc 780 cccaaatccc gccaccccga ggagcagcag aagatcctct ccttgtttta cagccttttc 840 aaccctatgc tgaacccgct gatctacagc ctgaggaaca ccgatgtcaa gggcgccctg 900 aggagagtgc tgtggatgga gagatcaatg tga 933

<210> 2474 <211> 310 <212> PRT <213> Felis catus

<400> 2474 Thr Trp Val Thr Glu Phe Ile Leu Leu Gly Phe Met Thr 1 Glu Asn Gln 5 10 15 Pro Leu Ser Pro Leu Thr Gln Val Phe Leu Phe Gly Leu Phe Ser Leu 20 25 30 Phe Tyr Ala Phe Thr Leu Leu Gly Asn Ser Thr Ile Leu Gly Leu Ile 35 40 45 Trp Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Val Val Asp Ile Ala Tyr Ala Ser Asn Asn Val Pro Lys Met 65 70 75 80 Leu Ala Asn Leu Leu Asn Lys Glu Lys Thr Ile Ser Phe Val Pro Cys 85 90 95 Ile Met Gln Thr Phe Leu Tyr Met Ala Phe Ala His Thr Glu Cys Leu 100 105 110

Page 2744

069269_0225_SL.TXT

Ile Leu Val 115 Met Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 120 125 Leu Arg Tyr Thr Val Ile Met Asn Trp Arg Val Cys Thr Val Gln Ala 130 135 140 Val Ile Ser Trp Ala Cys Gly Ser Leu Leu Ala Leu Val His Val Val 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro His Glu Ile Asn His Phe 165 170 175 Phe Cys Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Trp 180 185 190 Leu Asn Gln Val Val Ile Phe Ala Ala Ser Val Phe Ile Leu Val Gly 195 200 205 Pro Leu Cys Leu Val Leu Val Ser Tyr Thr Arg Ile Leu Phe Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val 245 250 255 Met Tyr Met Ala Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Ile 260 265 270 Leu Ser Leu Phe Tyr Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Thr Asp Val Lys Gly Ala Leu Arg Arg Val Leu 290 295 300 Trp Met Glu Arg Ser Met

305 310

Page 2745

069269_0225_SL.TXT <210> 2475 <211> 933 <212> DNA <213> Felis catus <400> 2475

atggggagaa ataagacctc tgtcacagag ttcatcctac tgggatttcc tctcaactca 60 aggattcaga tgcttctctt tgggctcttc tccctgttct atgccttcac cctgctgggg 120 aacgggctca tcctgagact catctggctg gactccagac tgcacacccc catgtacttc 180 ttcctctccc acctggccat cgttgacata gcctatgcct gcaacacggt gccccagatg 240 ctggtaaacc tcgtgaattc agacaagccc atctcctttg ctggctgcat gacacaaacc 300 tttcttttct tgagttttgc tcatactgaa tgtcttctcc tggtggtgat gtcctatgat 360 cggtatgtgg ccatctgcca cccgctccga tattctgtca tcatgagctg gagagtctgc 420 atcaccctgg cattgacttc ctggatttta ggagttctcc tagccctagt acatctagtg 480 ttactcatac cattgccctt ctgtggaccc cagaaagtta accacttttt ttgtgaaatt 540 atagctgtcc tcaaacttgc ctgtgcagat acccacatta atgagactat ggttttggct 600 ggggcagtat ctgtgttggt aggaccattc tcctccattg tgatatctta catttatatt 660 ttatgtgcca tcctaaagat tcaatcaggg gaggggcgcc agaaagcctt ctccacctgt 720 tcatcccacc tctgtgtggt tggactcttt tatggcacag ccattataat gtatgttggg 780 ccccataatg ggaaccctaa ggagcagaag aaatatctcc tcctgttcca cagccttttc 840 aatcccatgc tcaatcctct gatctatagt ctgaggaaca aagaagtcaa agctgctctg 900 aagaggatgc ttgaaaaaga gcgaacttca tga 933

<210> 2476 <211> 310 <212> PRT <213> Felis catus <400> 2476

Met Gly Arg Asn Lys Thr Ser Val Thr Glu Phe Ile Leu Leu Gly Phe

1 5 10 15

Pro Leu Asn Ser Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu

Page 2746

069269_0225_SL.TXT 25 30

Phe Tyr Ala 35 Phe Thr Leu Leu Gly Asn Gly Leu Ile Leu Arg Leu Ile 40 45 Trp Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Ile Val Asp Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met 65 70 75 80 Leu Val Asn Leu Val Asn Ser Asp Lys Pro Ile Ser Phe Ala Gly Cys 85 90 95 Met Thr Gln Thr Phe Leu Phe Leu Ser Phe Ala His Thr Glu Cys Leu 100 105 110 Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu Arg Tyr Ser Val Ile Met Ser Trp Arg Val Cys Ile Thr Leu Ala 130 135 140 Leu Thr Ser Trp Ile Leu Gly Val Leu Leu Ala Leu Val His Leu Val 145 150 155 160 Leu Leu Ile Pro Leu Pro Phe Cys Gly Pro Gln Lys Val Asn His Phe 165 170 175 Phe Cys Glu Ile Ile Ala Val Leu Lys Leu Ala Cys Ala Asp Thr His 180 185 190 Ile Asn Glu Thr Met Val Leu Ala Gly Ala Val Ser Val Leu Val Gly 195 200 205 Pro Phe Ser Ser Ile Val Ile Ser Tyr Ile Tyr Ile Leu Cys Ala Ile 210 215 220 Leu Lys Ile Gln Ser Gly Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys

Page 2747

0 6926 9_02 25_S L.TX T 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Tyr Gly Thr Ala Ile Ile 245 250 255 Met Tyr Val Gly Pro His Asn Gly Asn Pro Lys Glu Gln Lys Lys Tyr 260 265 270 Leu Leu Leu Phe His Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Leu Lys Arg Met Leu 290 295 300 Glu Lys Glu Arg Thr Ser

305 310 <210> 2477 <211> 928 <212> DNA <213> Felis catus <400> 2477

atgggaagca atcagacatg gatcacagaa gtcatcctgc tgggattcca ggttgacccc 60 aaacttgaac ttttcctctt tgggttcttc ttgctattct atagcctcac gctgatggga 120 aatgggatgg tcctggggct catctgctgg gattctacac tgcacacccc catgtacttc 180 ttcctctcaa acctggccat tgttgacatg tcctatgcct caagcattgt ccccaagatg 240 ctggcaaatc ttacaatgca gaagaaaacc atctcctttg ctccatgcct acttcagact 300 tttttgtatt tggcacttgc tgtaacagag tgtacaagtt tggtggtaat gtcctatgat 360 aggtatgtgg ccatctgtca ccccctacat tacgctgtca tcatgagctg gagagtgtgc 420 actatcctgg ctgccacttg ctggatattc agcttcctct tggctctggt ccatattact 480 ctcatcctga ggttgccctt ttgtgggcca caaacaatcg accacttttt ctgtcaaatc 540 atgtccgtat tcagattggc ctgtgctgac actacactca accaaactgt tctctttgtg 600 ggctctgtgt ttgttttagt cgggcccctc tgcctggtgc tggtgtccta cacgtgcatc 660 ctgttcgcca tcctgaggat ccagtcctcg gagagccaaa gaaaggcctt ctccacctgc 720

Page 2748

069269_0225_SL.TXT tcctcccacc tctgcgtggt ggggctcttc tttggaagtg ccattgtcat gtacatggcc cccaaatccc gccattctca agaacaaaga aagatactat cattgtttta cagccttttc aaccctatgc taaacccact gatctacagc ctgaggaatg ctgaggtgaa gggtgccctg aggagatttc agaggaagaa gacatcag

780

840

900

928 <210> 2478 <211> 310 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (310)..(310) <223> Any amino acid

<400> 2478 Thr Trp Ile Thr Glu Val Ile Leu Leu Gly Phe Met 1 Gly Ser Asn Gln 5 10 15 Gln Val Asp Pro Lys Leu Glu Leu Phe Leu Phe Gly Phe Phe Leu Leu 20 25 30 Phe Tyr Ser Leu Thr Leu Met Gly Asn Gly Met Val Leu Gly Leu Ile 35 40 45 Cys Trp Asp Ser Thr Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn 50 55 60 Leu Ala Ile Val Asp Met Ser Tyr Ala Ser Ser Ile Val Pro Lys Met 65 70 75 80 Leu Ala Asn Leu Thr Met Gln Lys Lys Thr Ile Ser Phe Ala Pro Cys 85 90 95 Leu Leu Gln Thr Phe Leu Tyr Leu Ala Leu Ala Val Thr Glu Cys Thr 100 105 110 Ser Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125

Page 2749

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Leu His 130 Tyr Ala Val Ile Met Ser Trp Arg Val Cys Thr Ile Leu Ala 135 140 Ala Thr Cys Trp Ile Phe Ser Phe Leu Leu Ala Leu Val His Ile Thr 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro Gln Thr Ile Asp His Phe 165 170 175 Phe Cys Gln Ile Met Ser Val Phe Arg Leu Ala Cys Ala Asp Thr Thr 180 185 190 Leu Asn Gln Thr Val Leu Phe Val Gly Ser Val Phe Val Leu Val Gly 195 200 205 Pro Leu Cys Leu Val Leu Val Ser Tyr Thr Cys Ile Leu Phe Ala Ile 210 215 220 Leu Arg Ile Gln Ser Ser Glu Ser Gln Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val 245 250 255 Met Tyr Met Ala Pro Lys Ser Arg His Ser Gln Glu Gln Arg Lys Ile 260 265 270 Leu Ser Leu Phe Tyr Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Ala Glu Val Lys Gly Ala Leu Arg Arg Phe Gln

290 295 300

Arg Lys Lys Thr Ser Xaa 305 310 <210> 2479 <211> 933

Page 2750

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 2479 atgggaagca accagacatg ggtcacagaa gtcaccttgc tgggattcca ggtttatcca 60 gcactggagt tttttctctt tggacttttc tgtctcttct atagcctcac tcttctgggg 120 aatggggtca tcttagggct tatctgctta gactctagac tgcacacccc catgtacttc 180 ttcctctccc atctggccat cgttgatatg tcctatgctt ccaacaatgt acccaaaatg 240 ctggcaaatc ttttgactca gagaagaacc atatcctttg ttccttgcat tatgcagact 300 tttttgtatc tagcttttgc tcacgcagag tgcctgattt tggtcgtgat gtcctatgat 360 aggcttgtgg cgatctgcaa tcccctacat tacactgtca tcatgagctg gagagtgtgc 420 acagtcctgg ccatcacttc ctgggtgttt agcttcctcc tggccctcgt ccatttaatt 480 ctcatcctga ggctgccctt ctgtggacct catgaaatca atcacttctt ctgcgaaatc 540 ctatctgtcc tcaagctggc ctgcgctgac acctggctca accaagctgt catttttgcg 600 gcctgtgtat ttatcttagt cgggcccctc tgcctggtgc tggtgtccta cacgcgcatc 660 ctgttcgcca tcctgaggat ccagtccggg gagggccgca gaaaggcctt ctccacctgc 720 tcctcccacc tctgcgtggt ggggctcttc tttggaagcg ccattgtcat gtacatggcc 780 cccaaatccc gccaccctga ggagcagcag aagatccttt ccttgtttta cagccttttc 840 aaccctatgc tgaacccgct gatctacagc ctgaggaaca cagaggtcaa gggcgccctg 900 aggagaacac tgtacaaaca gaggcatgta tga 933 <210> 2480 <211> 310 <212> PRT <213> Felis catus <400> 2480

Met Gly Ser Asn Gln Thr Trp Val Thr Glu Val Thr Leu Leu Gly Phe 1 5 10 15 Gln Val Tyr Pro Ala Leu Glu Phe Phe Leu Phe Gly Leu Phe Cys Leu 20 25 30 Phe Tyr Ser Leu Thr Leu Leu Gly Asn Gly Val Ile Leu Gly Leu Ile

Page 2751

069269_0225_SL.TXT 40 45

Cys Leu 50 Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 55 60 Leu Ala Ile Val Asp Met Ser Tyr Ala Ser Asn Asn Val Pro Lys Met 65 70 75 80 Leu Ala Asn Leu Leu Thr Gln Arg Arg Thr Ile Ser Phe Val Pro Cys 85 90 95 Ile Met Gln Thr Phe Leu Tyr Leu Ala Phe Ala His Ala Glu Cys Leu 100 105 110 Ile Leu Val Val Met Ser Tyr Asp Arg Leu Val Ala Ile Cys Asn Pro 115 120 125 Leu His Tyr Thr Val Ile Met Ser Trp Arg Val Cys Thr Val Leu Ala 130 135 140 Ile Thr Ser Trp Val Phe Ser Phe Leu Leu Ala Leu Val His Leu Ile 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro His Glu Ile Asn His Phe 165 170 175 Phe Cys Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Trp 180 185 190 Leu Asn Gln Ala Val Ile Phe Ala Ala Cys Val Phe Ile Leu Val Gly 195 200 205 Pro Leu Cys Leu Val Leu Val Ser Tyr Thr Arg Ile Leu Phe Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Val

Page 2752

245 069269_0225_SL.TXT 250 255 Met Tyr Met Ala Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Ile 260 265 270 Leu Ser Leu Phe Tyr Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Thr Glu Val Lys Gly Ala Leu Arg Arg Thr Leu 290 295 300 Tyr Lys Gln Arg His Val 305 310

<210> 2481 <211> 930 <212> DNA <213> Felis catus <400> 2481 atgggaagca accagtcatg ggtcacagaa ttcatcttgg tgggattcca gctccgtgca 60 gagatggaag tgctcctctt ctggatcttc tccctgttct acatctttag cctgttggca 120 aacggcatga tcttgggact catctgtctg gactcgagac tacgcacccc catgtacttc 180 ttcctctccc acctggccat cattgacatt tcctatgcat ccaataatgt ccccaagatg 240 ttggcaaact tagtgaatca gaagagaacc atctcctttg ttccatgcgt aatgcagaca 300 tttttgtatt tgggttttgc tgctacggag tgcctgatct tggtggcgat gtcttatgat 360 aggtttgtgg caatctgcca ccccctccag tacactgtca tcatgagctg gagactgtgc 420 ctggtcctgg ctgtcacttc ctggtcatgt ggatttattc tggctctggt acatgcaatt 480 ctccttctac ggttgccctt ctgtggaccc cgagaagtga atcacctctt ctgtgaaatc 540 ctatctgtcc tcaagttggc ctgtgctgac acatggatca accaattggt tattcttgct 600 gcctgtatgt ttgtcttagt tgggcccctc agtttaatgc taatctccta catgtgcatc 660 ctctgggcca tccttaaaat ccagtctggg gaaggccgca gaaaggcctt ctccacctgt 720 tcatcccatc tctgtgtggt tggactcttc tttggcatag ccatggtcgt ttatatggtc 780 ccagattcca aacaacgaga agagcaagag aaaatattat ccctttttca tagtcttttt 840

Page 2753

069269_0225_SL.TXT aacccaatgc tgaaccctct catttacagc ctgaggaacg ctcaggtaaa ggcttctttg tatagagcac tgaagaaaag gtccatgtga

900

930 <210> 2482 <211> 309 <212> PRT <213> Felis catus

<400> 2482 Ser Trp Val Thr Glu Phe Ile Leu Val Gly Phe Met Gly 1 Ser Asn Gln 5 10 15 Gln Leu Arg Ala Glu Met Glu Val Leu Leu Phe Trp Ile Phe Ser Leu 20 25 30 Phe Tyr Ile Phe Ser Leu Leu Ala Asn Gly Met Ile Leu Gly Leu Ile 35 40 45 Cys Leu Asp Ser Arg Leu Arg Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Ile Ile Asp Ile Ser Tyr Ala Ser Asn Asn Val Pro Lys Met 65 70 75 80 Leu Ala Asn Leu Val Asn Gln Lys Arg Thr Ile Ser Phe Val Pro Cys 85 90 95 Val Met Gln Thr Phe Leu Tyr Leu Gly Phe Ala Ala Thr Glu Cys Leu 100 105 110 Ile Leu Val Ala Met Ser Tyr Asp Arg Phe Val Ala Ile Cys His Pro 115 120 125 Leu Gln Tyr Thr Val Ile Met Ser Trp Arg Leu Cys Leu Val Leu Ala 130 135 140 Val Thr Ser Trp Ser Cys Gly Phe Ile Leu Ala Leu Val His Ala Ile 145 150 155 160

Page 2754

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Leu Leu Leu Arg Leu Pro Phe Cys Gly Pro 170 Arg Glu Val Asn His Leu 175 165 Phe Cys Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Trp 180 185 190 Ile Asn Gln Leu Val Ile Leu Ala Ala Cys Met Phe Val Leu Val Gly 195 200 205 Pro Leu Ser Leu Met Leu Ile Ser Tyr Met Cys Ile Leu Trp Ala Ile 210 215 220 Leu Lys Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ile Ala Met Val 245 250 255 Val Tyr Met Val Pro Asp Ser Lys Gln Arg Glu Glu Gln Glu Lys Ile 260 265 270 Leu Ser Leu Phe His Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Ala Gln Val Lys Ala Ser Leu Tyr Arg Ala Leu 290 295 300 Lys Lys Arg Ser Met 305 <210> 2483 <211> 914 <212> DNA <213> Felis catus <400> 2483 atgggagcca atatgacctc tatcacagag tttaccctat tgggatttcc ccttgctctg aggattcaga tgcttctctt tggtatcttc tccctgttct acgcctttac i cctgctgggg aatgggctca tcctgggact catctggctg gactccagac tgcacacccc catgtacttc

120

180

Page 2755

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ttcctctccc acctggccat cgttgacata gcctatgcct gcaacacggt gccccagatg 240 ctggtaaacc tcctgaagcc agaccagccc atctcctttg ctggctgcat gacacagacc 300 tttctctttt tgacttttgc tgtcacagaa tgtcttctcc tggtggtgat gtcctatgat 360 cggtatgtgg ccatctgcca cccgctccga tatcctgtca tcatgagctg gagagtctgc 420 atcatgctgg tggtgacttc ctggaccttt ggagtccttc tgtctttgat tcatctcatg 480 ttacttctac ccttaccctt ctgtagatcc cagaaaatca atcacttttt ctgtgaaatc 540 atggctgttc tcaaacttgt ctgtgcagat acacacatca atgagattgt ggtattggct 600 ggagcaattt ccgtactagt gggacccttc tcctcgattg tagtctcata tatgtgcatc 660 ctctgtgcca tcctcaggat ccagtctggg gaaggtcaaa gaaaagcctt ctctacctgc 720 tcatcccatc tctgtgtggt tggactcttt tatggcacgg ccattataat gtatgttggg 780 cccagatatg ggaatcccaa ggagcagaag aaatatctcc tcctgtttca cagccttttc 840 aatcccatgc tcaaccccct gatctatagt cttaggaact cagaagtgaa gaatgcctta 900 aagagagtgc tggg 914

<210> 2484 <211> 305 <212> PRT <213> Felis catus <400> 2484

Met Gly Ala Asn Met Thr Ser Ile Thr Glu Phe Thr Leu Leu Gly Phe 1 5 10 15 Pro Leu Ala Leu Arg Ile Gln Met Leu Leu Phe Gly Ile Phe Ser Leu 20 25 30 Phe Tyr Ala Phe Thr Leu Leu Gly Asn Gly Leu Ile Leu Gly Leu Ile 35 40 45 Trp Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Ile Val Asp Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met 65 70 75 80

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Leu Val Asn Leu Leu 85 Lys Pro Asp Gln Pro Ile Ser Phe Ala Gly Cys 90 95 Met Thr Gln Thr Phe Leu Phe Leu Thr Phe Ala Val Thr Glu Cys Leu 100 105 110 Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu Arg Tyr Pro Val Ile Met Ser Trp Arg Val Cys Ile Met Leu Val 130 135 140 Val Thr Ser Trp Thr Phe Gly Val Leu Leu Ser Leu Ile His Leu Met 145 150 155 160 Leu Leu Leu Pro Leu Pro Phe Cys Arg Ser Gln Lys Ile Asn His Phe 165 170 175 Phe Cys Glu Ile Met Ala Val Leu Lys Leu Val Cys Ala Asp Thr His 180 185 190 Ile Asn Glu Ile Val Val Leu Ala Gly Ala Ile Ser Val Leu Val Gly 195 200 205 Pro Phe Ser Ser Ile Val Val Ser Tyr Met Cys Ile Leu Cys Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Gln Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Tyr Gly Thr Ala Ile Ile 245 250 255 Met Tyr Val Gly Pro Arg Tyr Gly Asn Pro Lys Glu Gln Lys Lys Tyr 260 265 270 Leu Leu Leu Phe His Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 275 280 285

Page 2757

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Tyr Ser Leu Arg Asn Ser Glu Val Lys Asn Ala Leu Lys Arg Val Leu 290 295 300

Gly

305 <210> 2485 <211> 943 <212> DNA <213> Felis catus <400> 2485 atggagaaaa atcgaacaat ggttacagaa ttcatcctac tgggattttg tcttggtcca 60 aggattcaca taatcctttt ttgggctctt ctccctgttc tatgccttca ccctcctggg 120 gaacgggctc atcctggggc tcatctggct ggactccaga ctgcacaccc ccatgtactt 180 cttcctctcc cacctggcca tcgttgacat agcctatgcc tgcaacacgg tgccccggat 240 gctggtaaac ctcctgaagc cagaccagcc catctccttt gctggctgca tgacgcagac 300 ctttcttttc ttgacttttg ctctaacaga atgtcttctc ctggtggtga tgtcctatga 360 tcggtatgtg gccatctgcc acccgctccg atattctgtc atcatgaact ggacaggctg 420 catcatcctg atggtgactt cctgggcatg tggctccctg ctggccctgg tccatgtggt 480 tctcatcctg aggctgccct tctgcgggcc tcatgaaatc aaccacttct tctgtgagat 540 cctgtctgtc ctcaagctgg cctgcgctga cacctggctc aaccaagttg tcatctttgt 600 tgcctgtgtg tttatcttag tcgggcccct ctgcctggtg ctggtgtcct acacgcgcat 660 cctgttcgcc atcctgagga tccagtccgg ggagggccgc agaaaggcct tctccacctg 720 ctcctcccac ctctgcgtgg tggggctctt ctttggaagc gccattgtca tgtacatggc 780 ccccaaatcc cgccaccccg aggagcagca gaagatcctc tccttgtttt acagcctttt 840 caaccctatg ctgaacccaa tgatctacag cctgagaaat gcagatgtca ggagtgccct 900 gaaaagggca atgtgcaagg aaagtcattc ccaattagag tga 943 <210> 2486 <211> 256 <212> PRT <213> Felis catus

Page 2758

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<400> 2486 Leu 5 Ser His Leu Ala Ile Val Asp Ile Ala Tyr Ala Met 1 Tyr Phe Phe 10 15 Cys Asn Thr Val Pro Arg Met Leu Val Asn Leu Leu Lys Pro Asp Gln 20 25 30 Pro Ile Ser Phe Ala Gly Cys Met Thr Gln Thr Phe Leu Phe Leu Thr 35 40 45 Phe Ala Leu Thr Glu Cys Leu Leu Leu Val Val Met Ser Tyr Asp Arg 50 55 60 Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Ser Val Ile Met Asn Trp 65 70 75 80 Thr Gly Cys Ile Ile Leu Met Val Thr Ser Trp Ala Cys Gly Ser Leu 85 90 95 Leu Ala Leu Val His Val Val Leu Ile Leu Arg Leu Pro Phe Cys Gly 100 105 110 Pro His Glu Ile Asn His Phe Phe Cys Glu Ile Leu Ser Val Leu Lys 115 120 125 Leu Ala Cys Ala Asp Thr Trp Leu Asn Gln Val Val Ile Phe Val Ala 130 135 140 Cys Val Phe Ile Leu Val Gly Pro Leu Cys Leu Val Leu Val Ser Tyr 145 150 155 160 Thr Arg Ile Leu Phe Ala Ile Leu Arg Ile Gln Ser Gly Glu Gly Arg 165 170 175 Arg Lys Ala Phe Ser Thr Cys Ser Ser His Leu Cys Val Val Gly Leu 180 185 190 Phe Phe Gly Ser Ala Ile Val Met Tyr Met Ala Pro Lys Ser Arg His 195 200 205

Page 2759

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Pro Glu Glu Gln Gln Lys Ile Leu 215 Ser Leu Phe Tyr Ser Leu Phe 220 Asn 210 Pro Met Leu Asn Pro Met Ile Tyr Ser Leu Arg Asn Ala Asp Val Arg 225 230 235 240 Ser Ala Leu Lys Arg Ala Met Cys Lys Glu Ser His Ser Gln Leu Glu 245 250 255

<210> 2487 <211> 942 <212> DNA <213> Felis catus <400> 2487 atgggggaaa atcagacatc agtcacagag ttcattctac tgggattttg tcttgaccca 60 gggattcaga tgcttctctt tgggctcttc tccctgttct atgccttcac cctgctgggg 120 aacgggctca tcctggggct catctggctg gactccagac tgcacacccc catgtacttc 180 ttcctctccc acctggccat tgttgacata gcctatgcct gcaacacggt gccccagatg 240 ctggtaaacc ttgtgaagcc agaccagccc atctcttttg ctggctgcat gacacagacc 300 tttcttttct tgagttttgc tcatactgaa tgtcttctcc tggtggtgat gtcctatgat 360 cggtatgtgg ccatctgcca cccactccga tattctgtca tcatgagctg gacaggctgc 420 atcatcctgg tagtgacttc ctgggcatgt ggctccctgc tggccctggt ccatgtggtt 480 ctcatcctga ggctgccctt ctgcgggcct catgaaatca accacttctt ctgtgagatc 540 ctgtctgtcc tcaagctggc ctgcgctgac acctggctca accaagttgt catctttgtt 600 gcctgtgtgt ttatcttagt tgggcccctc tgcctggtgc tggtgtccta cacgcgcatc 660 ctgttcgcca tcctgaggat ccagtccggg gagggccgca gaaaggcctt ctccacctgc 720 tcctcccacc tctgcgtggt ggggctcttc tttggaagcg ccattatcat gtacatggcc 780 cccaaatccc gccaccctga ggagcagcag aagatccttt tcctgtttta cagttttttc 840 aatcctatgc tgaacccaat gatctacagt ctgaggaatg cagaggtcaa gggcgccctg 900 aggagagtgc tatacaagga aagtcattcc taattggagt ga 942

Page 2760

069269_0225_SL.TXT <210> 2488 <211> 310 <212> PRT <213> Felis catus

<400> 2488 Ile Leu Leu Gly 15 Phe Met 1 Gly Glu Asn Gln Thr 5 Ser Val Thr Glu 10 Phe Cys Leu Asp Pro Gly Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu 20 25 30 Phe Tyr Ala Phe Thr Leu Leu Gly Asn Gly Leu Ile Leu Gly Leu Ile 35 40 45 Trp Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ala Ile Val Asp Ile Ala Tyr Ala Cys Asn Thr Val Pro Gln Met 65 70 75 80 Leu Val Asn Leu Val Lys Pro Asp Gln Pro Ile Ser Phe Ala Gly Cys 85 90 95 Met Thr Gln Thr Phe Leu Phe Leu Ser Phe Ala His Thr Glu Cys Leu 100 105 110 Leu Leu Val Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu Arg Tyr Ser Val Ile Met Ser Trp Thr Gly Cys Ile Ile Leu Val 130 135 140 Val Thr Ser Trp Ala Cys Gly Ser Leu Leu Ala Leu Val His Val Val 145 150 155 160 Leu Ile Leu Arg Leu Pro Phe Cys Gly Pro His Glu Ile Asn His Phe 165 170 175 Phe Cys Glu Ile Leu Ser Val Leu Lys Leu Ala Cys Ala Asp Thr Trp

Page 2761

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180 185 190

Leu Asn Gln 195 Val Val Ile Phe Val Ala Cys Val Phe Ile Leu Val Gly 200 205 Pro Leu Cys Leu Val Leu Val Ser Tyr Thr Arg Ile Leu Phe Ala Ile 210 215 220 Leu Arg Ile Gln Ser Gly Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Cys Val Val Gly Leu Phe Phe Gly Ser Ala Ile Ile 245 250 255 Met Tyr Met Ala Pro Lys Ser Arg His Pro Glu Glu Gln Gln Lys Ile 260 265 270 Leu Phe Leu Phe Tyr Ser Phe Phe Asn Pro Met Leu Asn Pro Met Ile 275 280 285 Tyr Ser Leu Arg Asn Ala Glu Val Lys Gly Ala Leu Arg Arg Val Leu 290 295 300 Tyr Lys Glu Ser His Ser 305 310

<210> 2489 <211> 942 <212> DNA <213> Felis catus <400> 2489 tcactttggc ctgagcccag ctctgctgag cattttgacc aaagccatcc gcacctcccg atttctcaga ctgtagataa gggggttgag tgtgggagtg acaaggctgt agaataggga gaccacgttg tcctggtgtg ggctgtggta ggcacccggc accatgtaca tgaacacagc agcaccataa aagagtccca ctaccatgat gtgcgaggag caggtggtga aggccttgtt tctggcctcc tcagaccgca tgcgtataac ggcgcccaac acgtggccat aggagatggc gatgagggaa aggggaagga caaggatcag caccccggag gtggacagcg ccaactcgta

120

180

240

300

360

Page 2762

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ggccgaggtg tctgcacagg agagcttcag cagggctggc acctcgcaga agaagtggtc 420 caggatgcgg gaggcacagt aggggaagtg cagagtgatg gaggtctgga tggaggcatt 480 gagcacacct gccagccagg aggaacccac catgagcagg cacacttgac gcctcatgag 540 cacaggatac tgtagagggt gacacacagc aacataacgg tcataggcca tgagggccaa 600 caggatgccc tcagccacac ccaacagggt caggaagaat atttgagctg cacaaccctc 660 aaaggagatg gaaccttctc cctgcaggaa gtgggatgcc atcttgggga tggcgaccag 720 gggaaagcca acatcaaaca cagagagctg actgagaaga aagtacatgg gtgtgtggag 780 ccgggagtcc atgcggatca ggaagagcag aatggtattg cccaggaggc ccacggtaaa 840 cgtggcagcc accagggaga agagtagctg acgtgaacct gagtgactga agaggcccac 900 tagaatgaag tcagaggtca ctgactgatt cgcatccccc at 942

<210> 2490 <211> 313 <212> PRT <213> Felis catus <400> 2490

Met Gly Asp Ala Asn Gln Ser Val Thr Ser Asp Phe Ile Leu Val Gly 1 5 10 15 Leu Phe Ser His Ser Gly Ser Arg Gln Leu Leu Phe Ser Leu Val Ala 20 25 30 Ala Thr Phe Thr Val Gly Leu Leu Gly Asn Thr Ile Leu Leu Phe Leu 35 40 45 Ile Arg Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 Gln Leu Ser Val Phe Asp Val Gly Phe Pro Leu Val Ala Ile Pro Lys 65 70 75 80 Met Ala Ser His Phe Leu Gln Gly Glu Gly Ser Ile Ser Phe Glu Gly 85 90 95

Page 2763

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Cys Ala Ala Gln 100 Ile Phe Phe Leu Thr Leu Leu Gly Val Ala Glu Gly 105 110 Ile Leu Leu Ala Leu Met Ala Tyr Asp Arg Tyr Val Ala Val Cys His 115 120 125 Pro Leu Gln Tyr Pro Val Leu Met Arg Arg Gln Val Cys Leu Leu Met 130 135 140 Val Gly Ser Ser Trp Leu Ala Gly Val Leu Asn Ala Ser Ile Gln Thr 145 150 155 160 Ser Ile Thr Leu His Phe Pro Tyr Cys Ala Ser Arg Ile Leu Asp His 165 170 175 Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr 180 185 190 Ser Ala Tyr Glu Leu Ala Leu Ser Thr Ser Gly Val Leu Ile Leu Val 195 200 205 Leu Pro Leu Ser Leu Ile Ala Ile Ser Tyr Gly His Val Leu Gly Ala 210 215 220 Val Ile Arg Met Arg Ser Glu Glu Ala Arg Asn Lys Ala Phe Thr Thr 225 230 235 240 Cys Ser Ser His Ile Met Val Val Gly Leu Phe Tyr Gly Ala Ala Val 245 250 255 Phe Met Tyr Met Val Pro Gly Ala Tyr His Ser Pro His Gln Asp Asn 260 265 270 Val Val Ser Leu Phe Tyr Ser Leu Val Thr Pro Thr Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Glu Val Arg Met Ala Leu Val Lys Met 290 295 300

Page 2764

069269_0225_SL.TXT Leu Ser Arg Ala Gly Leu Arg Pro Lys 305 310 <210> 2491 <211> 942 <212> DNA <213> Felis catus <400> 2491

tcaggaagat gaaatgatct ttctgttggc aagcttcctc agggccccct ttagatctct 60 gttcctcaag ctatagataa aggggttcag catgggggtg actgtagtgt acatcacagc 120 agaagctttc tccttcacag ctgtgcggac agaggaggga cacagataga ccccaatggt 180 ggtcccataa aggagagcaa ccacagagag gtgggagctg caggtggaaa aggctttctt 240 cctgccccct gcagaaggga ctttcatgat ggccacaatg atgcgagcat aggaggccag 300 gatgcagata aaaggcgcgg ctatcaccag cccagccaca atgagcacaa agatcttgtt 360 cacagacgtg tcagtgcaag aaagcctgag aaggggagtg aggtcacaga agtagtgagg 420 tagctcattg ttcccacaga aaaccagacg agccatcagg aggatatgag tgagggagat 480 gaagcaggaa aacacccatg ggccacctgc cagcaggcca cagaggtgtg ggctcatgat 540 ggcagtatag tgtaaggggt aacatatagc cacaaacctg tcataagcca tcacggcaat 600 caggacactg tccatgatgc caaagaaatg gaaaaagtac atctgggtca ggcagcaggc 660 ataggagatt gacttgctcc tgatttggat gtttaccagc atcttgggga ctgtgttggt 720 ggccaggcag aaatcaacca aagacaggtt agctaagaag aagtacatgg gggtgtggag 780 gtgggagtct gagctgatgg ccaggatgat gagcaggttc cccagtactg tgaccacata 840 catgcagagg aacagagcaa agagaagggt ctcctgctct ggagtttctg aaagccccag 900 gaggatgaat tctaatgcgc tggttcggtt ccttggttcc at 942

<210> 2492 <211> 313 <212> PRT <213> Felis catus <400> 2492

Met Glu Pro Arg Asn Arg Thr Ser Ala Leu Glu Phe Ile Leu Leu Gly 1 5 10 15

Page 2765

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Leu Ser Glu Thr 20 Pro Glu Gln Glu Thr Leu Leu Phe Ala Leu Phe Leu 25 30 Cys Met Tyr Val Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Leu Val Asp Phe Cys Leu Ala Thr Asn Thr Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Ile Arg Ser Lys Ser Ile Ser Tyr Ala Cys 85 90 95 Cys Leu Thr Gln Met Tyr Phe Phe His Phe Phe Gly Ile Met Asp Ser 100 105 110 Val Leu Ile Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Tyr 115 120 125 Pro Leu His Tyr Thr Ala Ile Met Ser Pro His Leu Cys Gly Leu Leu 130 135 140 Ala Gly Gly Pro Trp Val Phe Ser Cys Phe Ile Ser Leu Thr His Ile 145 150 155 160 Leu Leu Met Ala Arg Leu Val Phe Cys Gly Asn Asn Glu Leu Pro His 165 170 175 Tyr Phe Cys Asp Leu Thr Pro Leu Leu Arg Leu Ser Cys Thr Asp Thr 180 185 190 Ser Val Asn Lys Ile Phe Val Leu Ile Val Ala Gly Leu Val Ile Ala 195 200 205 Ala Pro Phe Ile Cys Ile Leu Ala Ser Tyr Ala Arg Ile Ile Val Ala 210 215 220

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Ile Met 225 Lys Val Pro Ser Ala Gly Gly Arg Lys Lys Ala Phe Ser Thr 240 230 235 Cys Ser Ser His Leu Ser Val Val Ala Leu Leu Tyr Gly Thr Thr Ile 245 250 255 Gly Val Tyr Leu Cys Pro Ser Ser Val Arg Thr Ala Val Lys Glu Lys 260 265 270 Ala Ser Ala Val Met Tyr Thr Thr Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Leu Lys Gly Ala Leu Arg Lys Leu 290 295 300 Ala Asn Arg Lys Ile Ile Ser Ser Ser 305 310

<210> 2493 <211> 939 <212> DNA <213> Felis catus <400> 2493

atggaaccca gaaatcacac aggtgtttca gaatttcttc tcctgggatt gacagatgat 60 ccagaactgc agcccttcct attctgcctg ttcttgtcta tgtacctggt cactatcctg 120 ggaaatctgc tcatcatcct ggccatcagc tctgactcac acctccacac ccccatgtac 180 ttcttcctct ccaacctttc ctttactgac atctgtttaa gcacaaccac gatcccaaag 240 atgttggtga acatccaggc acagaatcag agcatcacgt atagaggctg tctcacccag 300 gttggatttg tcctggcttt tggtggtttt gaaaattttc tccttgcagc aatggcctat 360 gatcgctatg tggccatttg tcaccccttg aggtacaccg ttatcatgaa cccccaactc 420 tgtgttctgc tgattctact ctcactgttc tttagcgttg tggttgcctt gctccatagt 480 ctgatggtgc tacggttatc cttctgcaag gacttggaaa tccctcactt cttctgtgaa 540 cttgctcagg tcatcaaact cgcatgttct gataccctca tcaataacat cctgatatat 600 tttgtagcta gcctatttgg tggtattcct ctctccggaa tcattttctc ttatactcaa 660

Page 2767

069269_0225_SL.TXT attgtttcct ccgttttgag agtgccatca gcagggggaa agctcaaagc tttttccacc tgtgggtctc acttgtcagt tgtttctttg ttctatggaa cagttgttgg agtgtacatt agttctgtag ttactgactc ttccaagaag actgcagtag cttcagtgat gtatgttgtg gttcctcaaa tgatgaaccc ctttatctat agcctgcaga acagagacat gaagggagcc ttgagaaaac tcatcaatgg gatgccttct ttgctgtga

720

780

840

900

939 <210> 2494 <211> 312 <212> PRT <213> Felis catus

<400> 2494 Arg Asn 5 His Thr Gly Val Ser Glu Phe Leu Leu Leu Gly Met 1 Glu Pro 10 15 Leu Thr Asp Asp Pro Glu Leu Gln Pro Phe Leu Phe Cys Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Thr Asp Ile Cys Leu Ser Thr Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Ala Gln Asn Gln Ser Ile Thr Tyr Arg Gly 85 90 95 Cys Leu Thr Gln Val Gly Phe Val Leu Ala Phe Gly Gly Phe Glu Asn 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Pro Gln Leu Cys Val Leu Leu 130 135 140

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Ile 145 Leu Leu Ser Leu Phe 150 Phe Ser Val Val Val Ala Leu Leu His Ser 155 160 Leu Met Val Leu Arg Leu Ser Phe Cys Lys Asp Leu Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Ala Gln Val Ile Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Leu Ile Tyr Phe Val Ala Ser Leu Phe Gly Gly 195 200 205 Ile Pro Leu Ser Gly Ile Ile Phe Ser Tyr Thr Gln Ile Val Ser Ser 210 215 220 Val Leu Arg Val Pro Ser Ala Gly Gly Lys Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Val Val 245 250 255 Gly Val Tyr Ile Ser Ser Val Val Thr Asp Ser Ser Lys Lys Thr Ala 260 265 270 Val Ala Ser Val Met Tyr Val Val Val Pro Gln Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Gln Asn Arg Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300 Ile Asn Gly Met Pro Ser Leu Leu

305 310 <210> 2495 <211> 916 <212> DNA <213> Felis catus <400> 2495

Page 2769

069269_0225_SL.TXT atggaaccag aaaaccaaac aagtgtaaca gaattcctcc tcctgggtct ctcagaaaat 60 ccagaatggc agcctcttct ctttgggcta ttcctgacca tgtatctgac cactgtgctc 120 gggaacctac tcatcatcct gactatcagc tctgactccc atctccatac acccatgtac 180 ttcttcctct cccacctggc cttcactgac atctgtttca gcaccaccac catccccaag 240 atgcttgtga acatccaaag acagagcaaa tctatcagtt acacaggctg cctcacccag 300 gtctgcttcg tcctgttttt tgcaggcttg gaaaactttc tccttgcagc aatggcttat 360 gaccggtatg tggccatctg ccatccactg aggtacacag tcatcatgaa cccccacctc 420 tgtggcctgc tgattctact ctccctgagc atcagcattg cagatgccct actccacagt 480 ctgatggtgt tgcgactctc cttctgcgca gacctgggaa ttgctcattt cttctgtgaa 540 cttgctcagg tcatcaagct cgcctgttct gataccctca tcaataacat cctggtgtat 600 ttagtgacta gcattttggg tggtattcct ttccttggga ttattttctc ttatactcaa 660 attgtctctt ccattctgag aatgccatca gctgggggga aacataaagc cttttccacc 720 tgtgggtctc atctctccgt ggtttccttg ttctatggga cagcttttgg ggtgtacatt 780 agttctgcag ttactcattc ttccaaggat actgcagtag cctccgtgat gtataccgtg 840 gtccctcaaa tgttgaaccc ttttatctat agcctgagga acaaggacat gaagggagcc 900 ttgaggaaac tgatct 916 <210> 2496 <211> 306 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (306)..(306) <223> Any amino acid <400> 2496

Met Glu Pro Glu Asn Gln Thr Ser Val Thr Glu Phe Leu Leu Leu Gly 1 5 10 15

Leu Ser Glu Asn Pro Glu Trp Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30

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Thr Met Tyr 35 Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Thr 40 45 Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ala Phe Thr Asp Ile Cys Phe Ser Thr Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Arg Gln Ser Lys Ser Ile Ser Tyr Thr Gly 85 90 95 Cys Leu Thr Gln Val Cys Phe Val Leu Phe Phe Ala Gly Leu Glu Asn 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Pro His Leu Cys Gly Leu Leu 130 135 140 Ile Leu Leu Ser Leu Ser Ile Ser Ile Ala Asp Ala Leu Leu His Ser 145 150 155 160 Leu Met Val Leu Arg Leu Ser Phe Cys Ala Asp Leu Gly Ile Ala His 165 170 175 Phe Phe Cys Glu Leu Ala Gln Val Ile Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Leu Val Tyr Leu Val Thr Ser Ile Leu Gly Gly 195 200 205 Ile Pro Phe Leu Gly Ile Ile Phe Ser Tyr Thr Gln Ile Val Ser Ser 210 215 220 Ile Leu Arg Met Pro Ser Ala Gly Gly Lys His Lys Ala Phe Ser Thr 225 230 235 240

Page 2771

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Cys Gly Ser His Leu 245 Ser Val Val Ser Leu Phe Tyr Gly Thr Ala Phe 250 255 Gly Val Tyr Ile Ser Ser Ala Val Thr His Ser Ser Lys Asp Thr Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Pro Gln Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300

Ile Xaa 305 <210> 2497 <211> 939 <212> DNA <213> Felis catus <400> 2497 atggaaccca gaaacaaaac aggagtttct gaattccttc tcttgggatt gacggaggat ccagaactgc agcccctagt ctttagtctg tttctgtcca tgtacctggt caccatcctg ggaaacctgc tcatcatcct ggccatcagc tcagactccc acctccacac ccccatgtac ttcttcctct ccaacctgtc ctttactgac atctgtttaa gtacagccac gatcccaaag atgctggtga acatccaggc acagaatcag agcatcactt atgcaggctg cctcacacag atctgctttg tcttggtttt tgttggtttg gaaaattttc ttcttgcagc aatggcctat gaccgctatg tagccatctg ccatcccctg aggtacaccg ttatcatgaa cctccgactc tgtggtctgc tgatggtgct ctcactgtcc attagtagtg ccaatgccct gctccatagt ctgatggtgc tacggttttc cttctgcaag gacttgggca tcccacaatt cttctgtgag cttggtcagg tggtcaagct tgcttgttct gacaccctca tcaataatat cctggtatat tttatggcta gcttacttgg gggtgttcct ttctctggaa tcattttctc ttatactcaa attttctcct ctgttttgag aatgccatca gcgggcagga agtataaagc tttttccacc tgtgggtctc acctgtcagt tgtgttcttg ttctatggga caagtattgg agtgtacatt Page 2772

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069269_0225_SL.TXT aattctgcag ttactgactc ttccaggaag actaacatgg cttcagtgat gtacattgtc attcctcaaa tgatgaaccc ctttatctac agtctgagga acagtgacat gcagggtgtc ttgaagaaac ttgtcagtag gataccttct cttctgtga

840

900

939 <210> 2498 <211> 312 <212> PRT <213> Felis catus

<400> 2498 Lys Thr Gly Val Ser Glu Phe Leu Leu Leu Gly Met Glu 1 Pro Arg Asn 5 10 15 Leu Thr Glu Asp Pro Glu Leu Gln Pro Leu Val Phe Ser Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Thr Asp Ile Cys Leu Ser Thr Ala Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Ala Gln Asn Gln Ser Ile Thr Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Ile Cys Phe Val Leu Val Phe Val Gly Leu Glu Asn 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Leu Arg Leu Cys Gly Leu Leu 130 135 140 Met Val Leu Ser Leu Ser Ile Ser Ser Ala Asn Ala Leu Leu His Ser 145 150 155 160

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Leu Met Val Leu Arg 165 Phe Ser Phe Cys Lys Asp Leu Gly Ile Pro Gln 170 175 Phe Phe Cys Glu Leu Gly Gln Val Val Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Ile Leu Val Tyr Phe Met Ala Ser Leu Leu Gly Gly 195 200 205 Val Pro Phe Ser Gly Ile Ile Phe Ser Tyr Thr Gln Ile Phe Ser Ser 210 215 220 Val Leu Arg Met Pro Ser Ala Gly Arg Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Phe Leu Phe Tyr Gly Thr Ser Ile 245 250 255 Gly Val Tyr Ile Asn Ser Ala Val Thr Asp Ser Ser Arg Lys Thr Asn 260 265 270 Met Ala Ser Val Met Tyr Ile Val Ile Pro Gln Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Ser Asp Met Gln Gly Val Leu Lys Lys Leu 290 295 300 Val Ser Arg Ile Pro Ser Leu Leu

305 310 <210> 2499 <211> 939 <212> DNA <213> Felis catus <400> 2499 tcacagagga gaaggtgtcc tacttacgag ttttctcaag gctcccttca tatccctgtt cctcaggctg tagatgaaag ggttcatcat ttgagggaca acagtgtaca tcactgaaag

120

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caccgcagtg tttctggaag agttagtaaa agcagaacta atgtacaccc ccaaacctgt 180 cccatagaac aaagacacaa ctgacaggtg agacccacac gtagaaaacg ctttatactt 240 tctgcccacg gatggcatcc tcaaaacaga ggacactatc tgagtgtaag agaaaatgac 300 tccacacaca gggataccac cgaataggct agctgcaaaa tatatcagga tgttattgac 360 gagggtgtca gaacaggcga gcttgatgac ctgaacaact tcacagaaga agagagggat 420 ttcgacgtct gtgcagaagg tcagctgcaa caccatcaga ctgtgcatca gggcatccac 480 agtgctaatg cacaaggaga ctagaatcag caggccacag aagtgggagt tcatgatgac 540 tgtgtacctc agtgggtgac aaatggccac atagcgatca taggccattg ccgcaagaag 600 aaaactttcc aaaccaccaa aagccaggac aaagtagatc tgggtgaggc agcctgcata 660 agtgatgctc tgactctgtg cctggatgtt caccagcatc tttgggatcg tggttgtgct 720 taaacagatg tcagtaaagg acaggttgga gaggaagaag tacatggggg tgtggaggtg 780 ggagtccgag ctgacggcca ggacgataag caggtttccc aggatggtga ccaggtatat 840 ggacagaaac agaataaaga gaaagggctt cagttctgga tcctctgtca cttgcataag 900 aaggaattcg gaaactgctg ttttgttgct gggtcccat 939

<210> 2500 <211> 312 <212> PRT <213> Felis catus

<400> 2500 Met Gly Pro Ser Asn Lys Thr Ala Val Ser 10 Glu Phe Leu Leu Met 15 Gln 1 5 Val Thr Glu Asp Pro Glu Leu Lys Pro Phe Leu Phe Ile Leu Phe Leu 20 25 30 Ser Ile Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Val Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Thr Asp Ile Cys Leu Ser Thr Thr Thr Ile Pro Lys Page 2775

069269_0225_SL.TXT

Met Leu Val Asn Ile Gln Ala Gln Ser Gln Ser Ile Thr Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Ile Tyr Phe Val Leu Ala Phe Gly Gly Leu Glu Ser 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Ser His Phe Cys Gly Leu Leu 130 135 140 Ile Leu Val Ser Leu Cys Ile Ser Thr Val Asp Ala Leu Met His Ser 145 150 155 160 Leu Met Val Leu Gln Leu Thr Phe Cys Thr Asp Val Glu Ile Pro Leu 165 170 175 Phe Phe Cys Glu Val Val Gln Val Ile Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Val Asn Asn Ile Leu Ile Tyr Phe Ala Ala Ser Leu Phe Gly Gly 195 200 205 Ile Pro Val Cys Gly Val Ile Phe Ser Tyr Thr Gln Ile Val Ser Ser 210 215 220 Val Leu Arg Met Pro Ser Val Gly Arg Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Gly Leu 245 250 255 Gly Val Tyr Ile Ser Ser Ala Phe Thr Asn Ser Ser Arg Asn Thr Ala 260 265 270 Val Leu Ser Val Met Tyr Thr Val Val Pro Gln Met Met Asn Pro Phe

Page 2776

06926 9_0225_SL.TX T 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300 Val Ser Arg Thr Pro Ser Pro Leu 305 310

<210> 2501 <211> 932 <212> DNA <213> Felis catus <400> 2501

tcacagaaga gaagttctac ttatcagttt cctcaaggct cccttcatat ccctgttcct 60 caggctgtag ataaaagggt tcatcatttg agggacaaca gtgtacatca ttgaaagcac 120 tgcagtgttt ctggaagagt tagtaaaagc agaactaatg tacaccccca aacctgtccc 180 atagaacaaa gacacgacag gtgagaccca cacgtagaaa acgctttata ctttctgccc 240 acggatggca tcctcaaaac agaggacact atctgagtgt aagagaaaat gattccacat 300 aaaggaatac caccaaatac gctagttgca aaatatatca ggatgttatt gatgagggtg 360 tcagaacagg cgagcttgat cacctgaaca acctcacaga agaagagagg gatttcgacg 420 tctgtgcaga aggtcagctg caacaccatc agactgtgca ccagggcatc cacgatgata 480 atgaacaggg ggagtagaat cagcagacta cagaggcagg gcttcatgat gactgtgtac 540 cttagtggat gacaaacggc cacatagcgg tcataggcca ttactgcaag gagactactt 600 tctaaacttg caaaaactag aacaaagtag atctgggtga ggcagcctgc ataagtgatg 660 ctctgactct gggcctggat gttcaccagc atctttggga tcgtggttgt gcttaagcag 720 atgtcagtaa aggacaggtt ggagaggaag aagtacatgg gcgtgtggag gtgggagtcc 780 gaggtgacag ccaggatgat gagcaggttt cccaggatgg tgaccaggta catggacagg 840 aacaggctga ataggaggga ctgcagttct ggatcctctg tcactttcat gagaaggaaa 900 tctgaaacat gtgtgtcatt tctaggttcc at 932

<210> 2502 <211> 274

Page 2777

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 2502 Met 1 Glu Pro Arg Asn 5 Asp Thr His Val Ser Asp Phe Leu Leu Met Lys 10 15 Val Thr Glu Asp Pro Glu Leu Gln Ser Leu Leu Phe Ser Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Thr Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Thr Asp Ile Cys Leu Ser Thr Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Ala Gln Ser Gln Ser Ile Thr Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Ile Tyr Phe Val Leu Val Phe Ala Ser Leu Glu Ser 100 105 110 Ser Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Val Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Lys Pro Cys Leu Cys Ser Leu Leu 130 135 140 Ile Leu Leu Pro Leu Phe Ile Ile Ile Val Asp Ala Leu Val His Ser 145 150 155 160 Leu Met Val Leu Gln Leu Thr Phe Cys Thr Asp Val Glu Ile Pro Leu 165 170 175 Phe Phe Cys Glu Val Val Gln Val Ile Lys Leu Ala Cys Ser Asp Thr 180 185 190

Page 2778

Leu Ile Asn 195 Asn Ile Leu Ile 069269_0225_SL.TXT Tyr Phe Ala Thr Ser Val 200 205 Phe Gly Gly Ile Pro Leu Cys Gly Ile Ile Phe Ser Tyr Thr Gln Ile Val Ser Ser 210 215 220 Val Leu Arg Met Pro Ser Val Gly Arg Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Cys Leu Cys Ser Met Gly Gln Val Trp Gly 245 250 255 Cys Thr Leu Val Leu Leu Leu Leu Thr Leu Pro Glu Thr Leu Gln Cys 260 265 270

Phe Gln <210> 2503 <211> 931 <212> DNA <213> Felis catus <400> 2503

cacagtcaca gaagagaagt tctacttatc agtttcctca aggctccctt catgccctgt 60 tcctcaggtt gtagatgaaa gggttcatca tttgagggac aacagtgtac atcattgaaa 120 gcattgcagc atttctggaa gagtcagcaa gggcagaact gatgtagact ccaaaacctg 180 tcccatagaa caaagacaac tgagaggtga gacccacacg tactttatac tttccacctg 240 ctggtggcat cctcaaaaca gaggacacta tctgagtgta agagaaaatg attccacaca 300 cagggatacc accgaatagg ctagctgcaa aatatatcag gatgttattg acgagggtgt 360 cagaacaggc gagcttgatg acctgaacaa cttcacagaa gaagagaggg atttcgaggt 420 ctgcgcagaa ggtcagctgc aacaccacca gactgtgcgc cagggcatcc acgatgctaa 480 taaacaggga aagaagaatc aaaaggccac agagatggga gttcataatg acattgtacc 540 tcagtggatg acaaatggcc acatagcgat cataggccat ggctgaaaga atacaaccgt 600 ccaaacttgc aaaaaccaaa acaaagcaga tttgggtgag gcagcctggg taactgatgg 660

Page 2779

069269_0225_SL.TXT atttgctctg tgtctggatg ttcacaagca tctttgggat ggtagtggag gtgagacaga tgtcaacaaa agacaggttg gagaggaaga agtacatggg ggtgtggagg tgggagtcca agttaacagc caagatgatg agcagatttc ccaagatggt gaccagatac atggacagga acaggctgaa gatgagggac tgcagttctg gattctctgt cacttccatg agaagaaatt ctagaatgct tgtttcattt ccgagttcca t

720

780

840

900

931 <210> 2504 <211> 293 <212> PRT <213> Felis catus <400> 2504

Met Glu 1 Leu Gly Asn Glu Thr Ser Ile Leu Glu Phe Leu Leu Met 15 Glu 5 10 Val Thr Glu Asn Pro Glu Leu Gln Ser Leu Ile Phe Ser Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Ile Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Asn Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Leu Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr Gln Ser Lys Ser Ile Ser Tyr Pro Gly 85 90 95 Cys Leu Thr Gln Ile Cys Phe Val Leu Val Phe Ala Ser Leu Asp Gly 100 105 110 Cys Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Asn Val Ile Met Asn Ser His Leu Cys Gly Leu Leu 130 135 140

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Ile Leu Leu Ser 145 Leu Phe Ile Ser Ile Val Asp Ala Leu Ala His Ser 160 150 155 Leu Val Val Leu Gln Leu Thr Phe Cys Ala Asp Leu Glu Ile Pro Leu 165 170 175 Phe Phe Cys Glu Val Val Gln Val Ile Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Val Asn Asn Ile Leu Ile Tyr Phe Ala Ala Ser Leu Phe Gly Gly 195 200 205 Ile Pro Val Cys Gly Ile Ile Phe Ser Tyr Thr Gln Ile Val Ser Ser 210 215 220 Val Leu Arg Met Pro Pro Ala Gly Gly Lys Tyr Lys Val Arg Val Gly 225 230 235 240 Leu Thr Ser Gln Leu Ser Leu Phe Tyr Gly Thr Gly Phe Gly Val Tyr 245 250 255 Ile Ser Ser Ala Leu Ala Asp Ser Ser Arg Asn Ala Ala Met Leu Ser 260 265 270 Met Met Tyr Thr Val Val Pro Gln Met Met Asn Pro Phe Ile Tyr Asn 275 280 285 Leu Arg Asn Arg Ala

290 <210> 2505 <211> 939 <212> DNA

<213> Felis catus <400> 2505 atggaatcag aaaaccagac agaagtatca gaattcctcc tcctgggtct ctcagaggat ccaaaactgc agcccctcct gtttgggctg ttcctgtcca tgtacctggt cagcgtgctc gggaacctgc tcatcatcct ggctgtcagc tctgactccc acctccacac ccccatgtac Page 2781

120

180

069269_0225_SL.TXT ttcttcctct ccaacctgtc ctttgtcgac atctccttca cctccactat agtccccaaa atgctggtga acatccaaac acagagcaaa tctatcactt atggaggctg tctcattcaa gtatactttt tcatggtttt tatatgtatg gacaatttac tcctaactac gatggcttat gaccgctatg tggccatctg ccaccctctg cattacaggg tcatcatgaa ccctcgcctc tgtggcctgc tgattcttct ctccttgttc attagcatta tgaatgccct gctccacagt ctgatgctgg tgcacctgtc cttctgcaca gacttgaaaa tcccccattt cttctgtggg cttgctcaaa tccttgaact tgcctgttct gatactctta tcaataatgt cctggtgtat ttagtgacta gcctgttggg tgttggtcct ctctcaggga taattttctc ttacacccga attgtctctt ccatcttgag aatcccatca actggtggaa agttcaaagc tttttccacc tgtgggtctc acctgtctgt tgtttgctta ttctatggga cttgtgttgg agtctacctt agttctgcat cttctctctc tcccgggaag agggcagtgg cctcagtgat gtacacggta gtcactccca tgatgaaccc ctttatctac agcctgagga acagggacat caagggagcc ttgaggaaac tcatctctgg aatgtcttcg ttttcatga <210> 2506 <211> 312 <212> PRT <213> Felis catus

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720

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840

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939

<400> 2506 Met Glu Ser Glu 1 Asn Gln Thr Glu Val Ser Glu Phe Leu Leu Leu 15 Gly 5 10 Leu Ser Glu Asp Pro Lys Leu Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Ser Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Val Asp Ile Ser Phe Thr Ser Thr Ile Val Pro Lys 65 70 75 80

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Met Leu Val Asn Ile Gln Thr Gln Ser Lys Ser Ile Thr Tyr Gly Gly 85 90 95 Cys Leu Ile Gln Val Tyr Phe Phe Met Val Phe Ile Cys Met Asp Asn 100 105 110 Leu Leu Leu Thr Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Arg Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Ile Leu Leu Ser Leu Phe Ile Ser Ile Met Asn Ala Leu Leu His Ser 145 150 155 160 Leu Met Leu Val His Leu Ser Phe Cys Thr Asp Leu Lys Ile Pro His 165 170 175 Phe Phe Cys Gly Leu Ala Gln Ile Leu Glu Leu Ala Cys Ser Asp Thr 180 185 190 Leu Ile Asn Asn Val Leu Val Tyr Leu Val Thr Ser Leu Leu Gly Val 195 200 205 Gly Pro Leu Ser Gly Ile Ile Phe Ser Tyr Thr Arg Ile Val Ser Ser 210 215 220 Ile Leu Arg Ile Pro Ser Thr Gly Gly Lys Phe Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Cys Leu Phe Tyr Gly Thr Cys Val 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ser Ser Leu Ser Pro Gly Lys Arg Ala 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Met Asn Pro Phe 275 280 285

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Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Gly Ala Leu Arg Lys Leu 290 295 300

Ile Ser Gly Met Ser Ser Phe Ser

305 310 <210> 2507 <211> 939 <212> DNA <213> Felis catus <400> 2507

tcactggaag taagctcctc tcctgaaaag cttcctcaga gcccctttca tgtccctgtt 60 cctcaggctg tagatgaagg ggttcagcgt gggggtgacc actgtgtaca tcactgaggc 120 tattgaaccc tttctggacg gatgggctgt tccagaagtg aggtagaccc caaggcctgc 180 accatagaac aaggagacca ccaagaggtg ggacccacag gtggaaaagg ctttgtactt 240 ccccacagca gaagaaatgc ccattatgca ggagataatt ctagaataag agaaaaggat 300 cccagtcagg ggaataacac ccaacaggcc agttacaaaa tacagtagga tgtcattgac 360 aagggtgtca gaacaggcaa gcttgaggat ctgagcaagt tcacagaaga agtgggggat 420 ttctgtctct ttgcagaagg ccaccctcaa aaccatcaga ctttgcaaca aagaatatgt 480 caggcagatt aaccaagaaa gcagaagcag gagaccacag aggctagggt tcatgatgac 540 caggtagtgc agggggtgac agacggccac aaaccgatca taggccatca cggtcagtag 600 caaattatct aatccagcaa aaatcatgaa aaaacacatt tgggtaaggc agccttcata 660 cgtgatggcg ttgctccgtg tctggatgtt cactaacatc ttgaggacag tggtggaggt 720 gaaacagata tcagtgaggg acaggttggc gaggaagaag tacatggggg tgtggaggtg 780 ggggtcagag ctgatggcca gaacgatgag caggttccct aaaacacaga ccaggtacat 840 atagagaaac agcccaaaaa ggaggggctg caggtttata tcttctgaaa gccccagaag 900 gatgaatttt gaaatagctg tttggttccc tgcttccat 939

<210> 2508 <211> 312 <212> PRT

Page 2784

069269_0225_SL.TXT <213> Felis catus <400> 2508

Met Glu Ala Gly Asn Gln Thr Ala Ile Ser Lys Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Glu Asp Ile Asn Leu Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Tyr Met Tyr Leu Val Cys Val Leu Gly Asn Leu Leu Ile Val Leu Ala 35 40 45 Ile Ser Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Leu Thr Asp Ile Cys Phe Thr Ser Thr Thr Val Leu Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr Arg Ser Asn Ala Ile Thr Tyr Glu Gly 85 90 95 Cys Leu Thr Gln Met Cys Phe Phe Met Ile Phe Ala Gly Leu Asp Asn 100 105 110 Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Val Cys His 115 120 125 Pro Leu His Tyr Leu Val Ile Met Asn Pro Ser Leu Cys Gly Leu Leu 130 135 140 Leu Leu Leu Ser Trp Leu Ile Cys Leu Thr Tyr Ser Leu Leu Gln Ser 145 150 155 160 Leu Met Val Leu Arg Val Ala Phe Cys Lys Glu Thr Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Ala Gln Ile Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 Leu Val Asn Asp Ile Leu Leu Tyr Phe Val Thr Gly Leu Leu Gly Val

Page 2785

195 069269_0225_SL.TXT 200 205 Ile Pro Leu Thr Gly Ile Leu Phe Ser Tyr Ser Arg Ile Ile Ser Cys 210 215 220 Ile Met Gly Ile Ser Ser Ala Val Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Leu Val Val Ser Leu Phe Tyr Gly Ala Gly Leu 245 250 255 Gly Val Tyr Leu Thr Ser Gly Thr Ala His Pro Ser Arg Lys Gly Ser 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Thr Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300 Phe Arg Arg Gly Ala Tyr Phe Gln

305 310 <210> 2509 <211> 939 <212> DNA <213> Felis catus <400> 2509

atggaagcag gaaaccaaac aggaatttta gagttcatcc tccttgggtt ctctgaggat 60 ccagaactgc agcccttcat atctgggctg ttcctgtcca tgttcctgat cactgtgctc 120 gggaacctgc tcatcatcct ggccatctgc tctgaccccc acctccacac acccatgtac 180 ttcttcctct ccaacttgtc cttggtcgac atcagtttca gctccaccat cgtgcccagg 240 atgctggtga gcatccacac agagaacaaa gccatctctt atatggactg cctcactcag 300 gtctattttt ccatgttttt tcctatcctg gacactctcc tcctgaccgt gatggcctat 360 gaccggtttg tggccatctg ccaccccctg cactacatgg tcatcatgaa cccacccctc 420 tgtggcctgc tggtttttgt tacctggttt attggtgtca tgacctccct tcttcatatc 480

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tttctgatga tgcatctgag attctgtgga gatctcaaaa ttccacattt cttctgtgaa 540 ctgacacaga tcctcaagtt ggcctgctct gacaccttcc tgaacagcac attgatatac 600 tttatgactg gtgtgctagg tgtttttccc cttgtcggga tccttttctc ctactcacga 660 attgcttcat ccataaggaa gatgtcttca gctgggggaa ggcaaaaagc attctccacc 720 tgtgggtctc acctctcagt ggtttcttta ttttatggga caggtgttgg agtttacttc 780 acttctgcag tgactcactc ccccaagaaa gtctcagtgg cctcggtgat gtacaccgtg 840 gtcactccta tgctgaaccc cttcatctac agcctgagga acaaggatgt gaagggggcg 900 ctgagaaggc ttttcagtag agtggcttct tgtctgtga 939

<210> 2510 <211> 312 <212> PRT <213> Felis catus <400> 2510

Met Glu Ala Gly Asn Gln Thr Gly Ile Leu Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Glu Asp Pro Glu Leu Gln Pro Phe Ile Ser Gly Leu Phe Leu 20 25 30 Ser Met Phe Leu Ile Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Cys Ser Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Leu Val Asp Ile Ser Phe Ser Ser Thr Ile Val Pro Arg 65 70 75 80 Met Leu Val Ser Ile His Thr Glu Asn Lys Ala Ile Ser Tyr Met Asp 85 90 95 Cys Leu Thr Gln Val Tyr Phe Ser Met Phe Phe Pro Ile Leu Asp Thr 100 105 110

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Leu Leu Leu 115 Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 120 125 Pro Leu His Tyr Met Val Ile Met Asn Pro Pro Leu Cys Gly Leu Leu 130 135 140 Val Phe Val Thr Trp Phe Ile Gly Val Met Thr Ser Leu Leu His Ile 145 150 155 160 Phe Leu Met Met His Leu Arg Phe Cys Gly Asp Leu Lys Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Thr Gln Ile Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Ser Thr Leu Ile Tyr Phe Met Thr Gly Val Leu Gly Val 195 200 205 Phe Pro Leu Val Gly Ile Leu Phe Ser Tyr Ser Arg Ile Ala Ser Ser 210 215 220 Ile Arg Lys Met Ser Ser Ala Gly Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Gly Val 245 250 255 Gly Val Tyr Phe Thr Ser Ala Val Thr His Ser Pro Lys Lys Val Ser 260 265 270 Val Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Arg Leu 290 295 300 Phe Ser Arg Val Ala Ser Cys Leu

305 310

Page 2788

069269_0225_SL.TXT <210> 2511 <211> 939 <212> DNA <213> Felis catus <400> 2511

atggaagcag aaaaccagac agaagtatca gtattcctcc tccggggtct ctcagatgat 60 ccagaactgc agcctctcct ctttggcatg ttcctatcca tgtatctggt cactgtgctt 120 ggcaacctgc tcatcatcct ggctctcagc tctgactctc acctccacac ccccatgtac 180 ttcttcctct ccaacctgtc ctttgttgac atttgtttca tctccaccac tgtcccaaag 240 atgctggtga acatccagga atgcagcaaa ggcatttcct atctagaatg cctcattcaa 300 gtgtattttt ttatgatttt tgctggaatg gacgatttcc tcctgactgt gatggcctat 360 gaccggtttg tggccatctg ccacccccta cactacacag tcatcatgaa cccacgactc 420 tgtgtcctcc tggttctggg ttgttggctc acccttttct gggtctcctt gattcatatt 480 ctactggtga ggcggctggc cttctgtaca ggcactgaaa ttccacattt cttctgtgaa 540 ctggctcaga ttctccaggt agcctgctct gacactcgta tcaataacat ctgcttgtat 600 gttgccactg cactgctgtg tgtgtttcct ctcactggga tcctcttctc atactctcag 660 attgtctcct ccttaatgag gatgtcgtcc agtgagggca agtataaagc attttccacc 720 tgtgggtctc acctctctgt ggtcagtctg ttctatggga caagcctggg ggtctacctc 780 acttctgctg tgacccattc ttcccagaga agttcgattg cctcagtgat gtacactgtg 840 gtgaccccca tgttgaaccc cttcatctac agcttgagga acaaggatgt gaagggggcc 900 ctgcaaagat tcctcagcag agcaacctca tggccatga 939

<210> 2512 <211> 312 <212> PRT <213> Felis catus

<400> 2512 Met Glu Ala Glu Asn Gln Thr Glu Val Ser Val Phe Leu Leu Arg Gly 1 5 10 15

Leu Ser Asp Asp Pro Glu Leu Gln Pro Leu Leu Phe Gly Met Phe Leu 20 25 30

Page 2789

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Ser Met Tyr 35 Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 40 45 Leu Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Glu Cys Ser Lys Gly Ile Ser Tyr Leu Glu 85 90 95 Cys Leu Ile Gln Val Tyr Phe Phe Met Ile Phe Ala Gly Met Asp Asp 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Val Leu Leu 130 135 140 Val Leu Gly Cys Trp Leu Thr Leu Phe Trp Val Ser Leu Ile His Ile 145 150 155 160 Leu Leu Val Arg Arg Leu Ala Phe Cys Thr Gly Thr Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Ala Gln Ile Leu Gln Val Ala Cys Ser Asp Thr 180 185 190 Arg Ile Asn Asn Ile Cys Leu Tyr Val Ala Thr Ala Leu Leu Cys Val 195 200 205 Phe Pro Leu Thr Gly Ile Leu Phe Ser Tyr Ser Gln Ile Val Ser Ser 210 215 220 Leu Met Arg Met Ser Ser Ser Glu Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240

Page 2790

069269_0225_SL.TXT

Cys Gly Ser His Leu 245 Ser Val Val Ser Leu Phe Tyr Gly Thr Ser Leu 250 255 Gly Val Tyr Leu Thr Ser Ala Val Thr His Ser Ser Gln Arg Ser Ser 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Gln Arg Phe 290 295 300 Leu Ser Arg Ala Thr Ser Trp Pro 305 310

<210> 2513 <211> 996 <212> DNA <213> Felis catus <400> 2513

gcactcttga tgtccctgtt cctcaagctg taaatgaagg ggttcagcat gggggtgact 60 acggtgtaca caactgaggc caccatatcc ttcctgggag aaggcaacag tgctgatcca 120 aggtatactc caatagccgt tccataaaat aagcaaacaa ctgacaggtg agagccacag 180 gtggagaagg ctttgtactt cccacctgtt gatgggattc tcagaatgga agaaacaatt 240 ttatagtaag agaaaaagat ccctgagata gggagaaagc cagagatgac accaacaaaa 300 tacatgacta cgttattggt gaaagtgtca gagcaggcaa ggttgaggag ttgagaaggg 360 tcacagaaga aattagaaat ttccacatcc ttgaaacagg taagttgcaa cacgattaaa 420 ttgtgcaact gggagtccaa aaggctcaca caaaaggaca ccaaaactaa gaagccacag 480 agatgtgggt tcatgatgac tgagtagtgt agaggatgac agatggccac aaatcggtca 540 tatgccattg cagtcagaaa cataccatcc atacatccaa aaaggatcaa aaaagacatc 600 tgagtcaggc agcccacata ggagatgact ctgctctgag tttggatgtc cacaatcatc 660 ttagggacag tggtggagat gaatccgatg tcagccaagg acaggttgga gaggaagaag 720 tacatggggg tgtggaggtg agagtcagaa ctgacaacca gaatgatgag caggtttcca 780

Page 2791

069269_0225_SL.TXT agcacactga ccaggtacat ggacaggaag agcccaaaga ggaggggctg cagtcctgga ttatctgaga gtcccgtgag gaagaattcg gagacacttg ttagattttg ttctatgtag ctttgacacc tttagaaaac aaaaagaggg ttggagaaag gaaacaagta aatgggcatc cagcactgtg tccatgttgt atattcaagc gattca

840

900

960

996 <210> 2514 <211> 267 <212> PRT <213> Felis catus <400> 2514

Met Tyr Leu 1 Val Ser Val Leu Gly 5 Asn Leu Leu Ile Ile Leu Val Val 10 15 Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn 20 25 30 Leu Ser Leu Ala Asp Ile Gly Phe Ile Ser Thr Thr Val Pro Lys Met 35 40 45 Ile Val Asp Ile Gln Thr Gln Ser Arg Val Ile Ser Tyr Val Gly Cys 50 55 60 Leu Thr Gln Met Ser Phe Leu Ile Leu Phe Gly Cys Met Asp Gly Met 65 70 75 80 Phe Leu Thr Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro 85 90 95 Leu His Tyr Ser Val Ile Met Asn Pro His Leu Cys Gly Phe Leu Val 100 105 110 Leu Val Ser Phe Cys Val Ser Leu Leu Asp Ser Gln Leu His Asn Leu 115 120 125 Ile Val Leu Gln Leu Thr Cys Phe Lys Asp Val Glu Ile Ser Asn Phe 130 135 140

Page 2792

069269_0225_SL.TXT

Phe 145 Cys Asp Pro Ser Gln 150 Leu Leu Asn Leu Ala Cys Ser Asp Thr Phe 155 160 Thr Asn Asn Val Val Met Tyr Phe Val Gly Val Ile Ser Gly Phe Leu 165 170 175 Pro Ile Ser Gly Ile Phe Phe Ser Tyr Tyr Lys Ile Val Ser Ser Ile 180 185 190 Leu Arg Ile Pro Ser Thr Gly Gly Lys Tyr Lys Ala Phe Ser Thr Cys 195 200 205 Gly Ser His Leu Ser Val Val Cys Leu Phe Tyr Gly Thr Ala Ile Gly 210 215 220 Val Tyr Leu Gly Ser Ala Leu Leu Pro Ser Pro Arg Lys Asp Met Val 225 230 235 240 Ala Ser Val Val Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile 245 250 255 Tyr Ser Leu Arg Asn Arg Asp Ile Lys Ser Ala

260 265 <210> 2515 <211> 1022 <212> DNA <213> Felis catus <400> 2515

ttttgctgag gagcctctgc atggcccttt ggatgtccct gttcctcagg ctgtagatga 60 aagggttcaa catgggggtg accacagtat acaccaccga ggccactgca cccttcctgg 120 gggaagttga cacggctgaa ctgagataca ccccgagtcc tgttccataa aataagcaaa 180 caactgacag gtgagagcca caggtggaga aggctttgta cttcccacct gttgatggga 240 ttctcagaat ggaagaaaca attttatagt aagagaaaaa gatccctgag atagggagaa 300 agccagagat ggcaccaaca aaatacatga ctacgtcatt ggtgaaagtg tcagaacagg 360 caaggttgag gagttgagaa ggatcacaga agaaatgaga aatttccaca tccttgaagt 420

Page 2793

069269_0225_SL.TXT

aggtaagttg taacacgatc gaattgtgca tctgggagac caaaacgctg atgaaaagtg 480 atgccaaaac caacaagcca cagaggcgag ggttcatgat gaccaagtag cgcagggggt 540 gacagattgc cacaaaccgg tcatatgcca tcgcagccag gaggagacta tccaaacatc 600 caaaaagcat aaaaaaagac atctgagtca ggcagcccac atacgagatg actctgctct 660 gagtttggat gtccacaatc atcttgggga tggtagtaga ggtgaaaccg atgtcagcca 720 atgacaggtt ggagaggaaa aagtacatgg gggtgtgaag gtgcgggtca gagctgacgg 780 ccaggatgat gagcaggttc ccgagcacac tgaccaggta catagacagg aacagcccaa 840 agaggagggg ctgcagttct agatcatctg agagtcccgt gaggaagaat tctgaaaccc 900 ttgttagatt ttgtggttct atgtaccttg gacacctttt gaaaaagaaa agaaggttgg 960 agaaagtaaa caagtcaatg ggcattcagc actgtgtcca tattgtgtat tcaagcagtt 1020

ca 1022 <210> 2516 <211> 329 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (329)..(329) <223> Any amino acid <400> 2516

Met Pro Ile Asp Leu Phe Thr Phe Ser Asn Leu Leu Phe Phe Phe Lys 1 5 10 15

Arg Cys Pro Arg Tyr Ile Glu Pro Gln Asn Leu Thr Arg Val Ser Glu 20 25 30

Phe Phe Leu Thr Gly Leu Ser Asp Asp Leu Glu Leu Gln Pro Leu Leu 35 40 45

Phe Gly Leu Phe Leu Ser Met Tyr Leu Val Ser Val Leu Gly Asn Leu 50 55 60

Leu Ile Ile Leu Ala Val Ser Ser Asp Pro His Leu His Thr Pro Met Page 2794

069269_0225_SL.TXT

Tyr Phe Phe Leu Ser Asn Leu Ser Leu Ala Asp Ile Gly Phe Thr Ser 85 90 95 Thr Thr Ile Pro Lys Met Ile Val Asp Ile Gln Thr Gln Ser Arg Val 100 105 110 Ile Ser Tyr Val Gly Cys Leu Thr Gln Met Ser Phe Phe Met Leu Phe 115 120 125 Gly Cys Leu Asp Ser Leu Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe 130 135 140 Val Ala Ile Cys His Pro Leu Arg Tyr Leu Val Ile Met Asn Pro Arg 145 150 155 160 Leu Cys Gly Leu Leu Val Leu Ala Ser Leu Phe Ile Ser Val Leu Val 165 170 175 Ser Gln Met His Asn Ser Ile Val Leu Gln Leu Thr Tyr Phe Lys Asp 180 185 190 Val Glu Ile Ser His Phe Phe Cys Asp Pro Ser Gln Leu Leu Asn Leu 195 200 205 Ala Cys Ser Asp Thr Phe Thr Asn Asp Val Val Met Tyr Phe Val Gly 210 215 220 Ala Ile Ser Gly Phe Leu Pro Ile Ser Gly Ile Phe Phe Ser Tyr Tyr 225 230 235 240 Lys Ile Val Ser Ser Ile Leu Arg Ile Pro Ser Thr Gly Gly Lys Tyr 245 250 255 Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ser Val Val Cys Leu Phe 260 265 270 Tyr Gly Thr Gly Leu Gly Val Tyr Leu Ser Ser Ala Val Ser Thr Ser

Page 2795

0 6926 9_02 25_S iL.TX T 275 280 285 Pro Arg Lys Gly Ala Val Ala Ser Val Val Tyr Thr Val Val Thr Pro 290 295 300 Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Arg Asp Ile Gln Arg 305 310 315 320 Ala Met Gln Arg Leu Leu Ser Lys Xaa 325

<210> 2517 <211> 863 <212> DNA <213> Felis catus <400> 2517 ttctgaggta cctctctgtg gccctcttga tggccctgta cctcagacta gatgaagggg 60 agtgagcatg ggggtgacca cagtatacac caccaaggcc acctcaccct tcctgggaaa 120 atatgagaca gctaaactga ggtacactcc aagacctgtt gcagaaaata agccagtaac 180 taacaggtga cagccacagg tagaaaaggc tttgttactt cccacctgtg gatgggactc 240 tcggaatgga ggcaacaatt tgagtataag agaaaaggat ccctgagagt ggaacaccac 300 caaaaacggc accagtaaaa taaattcatg ggttattggt ggggatttcc aaggaggaaa 360 gtttgaatag ctgagaaggg ccatgaaaga aatgaggtat acttccacat ctgtgaagaa 420 ggttaagttg tgacaccatc agactgtgca actggtgaaa agctgatgaa aaaagacacc 480 aaaaccagca ggacacagag gtgggtagtg caagggatga cagatggcca caaaccgatc 540 ataggccatt gcggtcagta gattgtctta acatccaaaa agaataaaaa tagacatctg 600 agactacata agagatgatt cttctgtgag tatggatgtc cgcaatcatg ttggggacag 660 tagtagaagt gaaacgatgt cagccaagga caggttggag aggaagaagt acatgggggt 720 gtggaggtgg gggtcagggc tgacggccag gatgatcagc aggttcctga gcacagtgac 780 caggtacatg gacaggaaca tcccaaagag gagaggctgt cattctggat cctccaagag 840 gctcaggaag aagaattctg aga 863

Page 2796

069269_0225_SL.TXT <210> 2518 <211> 78 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (78)..(78) <223> Any amino acid <400> 2518

Met Asp Val Arg Asn His Val Gly Asp Ser Ser Arg Ser Glu Thr Met 1 5 10 15 Ser Ala Lys Asp Arg Leu Glu Arg Lys Lys Tyr Met Gly Val Trp Arg 20 25 30 Trp Gly Ser Gly Leu Thr Ala Arg Met Ile Ser Arg Phe Leu Ser Thr 35 40 45 Val Thr Arg Tyr Met Asp Arg Asn Ile Pro Lys Arg Arg Gly Cys His 50 55 60 Ser Gly Ser Ser Lys Arg Leu Arg Lys Lys Asn Ser Glu Xaa 65 70 75

<210> 2519 <211> 933 <212> DNA <213> Felis catus <400> 2519

acaaagggct ccacgactat ggagtcttct cagggccccc ttcacatcct tgttcctgag 60 gctgtagatg aaggggttca gcatgggggt gaccacagta tacatcactg aggcaattgg 120 gattctctgg gaagaatgaa tcccagcagg actgagatag agccccaagc ttgccccata 180 gtacaaggag accacagaga gatgtgagcc acaggttgaa aatgctttat attttcctgc 240 tgcagaggac attctcatta aagaggagac gatcagagag taggaaaaga agatcccagt 300 cagaggaaac acacccagta tggcagtcga cacatacaag aagatattat tgatacgagt 360 gtcagagcag gctacctgga gaatctgaac cacttcacag aagaaatgtg gaatttccgc 420

Page 2797

069269_0225_SL.TXT

acctgtacag aaggtcagcc gcctcaccag taggacatga atcagggaga cccagaaaat 480 gatgagccaa cacaccagaa ccagcaggcc acagagtcgt gggttcatga tgactgtgta 540 gtgcaggggg tggcagatgg ccacaaaccg gtcataggcc atcacggtca ggaggaaacc 600 atccattcca gcaaaaatca taaaaaagta cagctgagtg aggcatccag ggtaggagat 660 gtctttgctc tgtgcctgga tgtttaccag catcttcggg acagtggtgg aaatgaaaca 720 gatgtcaaca gaggacaggt tagagaggaa gaagtacatg ggggtgtgga ggttggaatc 780 agagaggatg gccaggatga tgagcaggtt tcctagcaca gtgactaggt acgtgaacag 840 aaacaagcca aagaggaggg gctgcagttc tgggtcatct gagaggcccc gaaggaagaa 900 ttctgatact ctggtatggt ttcctgcttc cat 933

<210> 2520 <211> 311 <212> PRT <213> Felis catus

<400> 2520 His Thr Arg Val Ser Glu Phe Phe Leu Arg Gly Met Glu 1 Ala Gly Asn 5 10 15 Leu Ser Asp Asp Pro Glu Leu Gln Pro Leu Leu Phe Gly Leu Phe Leu 20 25 30 Phe Thr Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Leu Ser Asp Ser Asn Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Ser Val Asp Ile Cys Phe Ile Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Ala Gln Ser Lys Asp Ile Ser Tyr Pro Gly 85 90 95 Cys Leu Thr Gln Leu Tyr Phe Phe Met Ile Phe Ala Gly Met Asp Gly 100 105 110

Page 2798

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Phe Leu Leu 115 Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Cys Trp Leu Ile Ile Phe Trp Val Ser Leu Ile His Val 145 150 155 160 Leu Leu Val Arg Arg Leu Thr Phe Cys Thr Gly Ala Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Val Val Gln Ile Leu Gln Val Ala Cys Ser Asp Thr 180 185 190 Arg Ile Asn Asn Ile Phe Leu Tyr Val Ser Thr Ala Ile Leu Gly Val 195 200 205 Phe Pro Leu Thr Gly Ile Phe Phe Ser Tyr Ser Leu Ile Val Ser Ser 210 215 220 Leu Met Arg Met Ser Ser Ala Ala Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Tyr Tyr Gly Ala Ser Leu 245 250 255 Gly Leu Tyr Leu Ser Pro Ala Gly Ile His Ser Ser Gln Arg Ile Pro 260 265 270 Ile Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Arg Leu 290 295 300 His Ser Arg Gly Ala Leu Cys

305 310

Page 2799

069269_0225_SL.TXT <210> 2521 <211> 754 <212> DNA <213> Felis catus <400> 2521 atctgagttt atatttctgg gactcactca ttcatgggag atccagcttc tcctcctggt 60 gttctcctct gtgctctata tggcaagcat gaccggaaac atcctcattg tgttttatgc 120 gaccattgat cctcacttac attcacctaa gtacttctta ctggctcgtc tctttttcat 180 tgacgtagga gcctgctctg ccaagatgct tcacccaaga tgatttatga ccttttcaga 240 aagcgcaaag ccatctcctt tggaggctgc attgtccaaa tcttcatcca cgtcattggt 300 ggtgtggaga tggtgcttct cgtcactatg gcctttgaca gatatgttgc catttgtaag 360 cctctccact acttgaccat catgagccca cgaatgtgca ttttgtttct ggctgctgcc 420 tgggctcttg gtgtcagtca ctcactgttc caactagcat ttattgttat tttacccttc 480 tgtggtccaa atgtattgga cagcttttac tgtgaccttc cttggctcct cagactggtc 540 tgtacagata cccacagatt gcagttcatg gtcactgtta acagtgggtt tatctgtgtt 600 ggttccttct ttatactctt catctcctac atcttcatcc tttttactct ttggaaacat 660 tccttaggtg gttcatccaa agccgtttcc accctgtcag ctcacaccac tgtggtcctt 720 ttgttcttcg gtccaaccat gtttgtctct acat 754 <210> 2522 <211> 179 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (179)..(179) <223> Any amino acid <400> 2522

Met Ile Tyr Asp Leu Phe Arg Lys Arg Lys Ala Ile Ser Phe Gly Gly 1 5 10 15 Cys Ile Val Gln Ile Phe Ile His Val Ile Gly Gly Val Glu Met Val

20 25 30

Page 2800

069269_0225_SL.TXT

Leu Leu Val Thr Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro 35 40 45 Leu His Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Ile Leu Phe Leu 50 55 60 Ala Ala Ala Trp Ala Leu Gly Val Ser His Ser Leu Phe Gln Leu Ala 65 70 75 80 Phe Ile Val Ile Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Ser Phe 85 90 95 Tyr Cys Asp Leu Pro Trp Leu Leu Arg Leu Val Cys Thr Asp Thr His 100 105 110 Arg Leu Gln Phe Met Val Thr Val Asn Ser Gly Phe Ile Cys Val Gly 115 120 125 Ser Phe Phe Ile Leu Phe Ile Ser Tyr Ile Phe Ile Leu Phe Thr Leu 130 135 140 Trp Lys His Ser Leu Gly Gly Ser Ser Lys Ala Val Ser Thr Leu Ser 145 150 155 160 Ala His Thr Thr Val Val Leu Leu Phe Phe Gly Pro Thr Met Phe Val 165 170 175

Ser Thr Xaa <210> 2523 <211> 945 <212> DNA <213> Felis catus <400> 2523 atgaacacaa acaatggaag tgccacagca gacttcatct tgctggggtt ttctgatcag ccccaggtag aacacatcat ctctggggtt gtcttcatct tctatattgt gactttggta

120

Page 2801

069269_0225_SL.TXT

ggaaacacag ccatcatcct tgtatctaac ctagacagcc agctccatac tcccatgtat 180 ttcttcctat ccaatttgtc ttttctggac ctctgttatg caactagcat tatcccacag 240 atgctggtaa atctatggag tccaacaaag tctattacct atggagggtg tgtgttccaa 300 ttcttctttg cccttgactt tggagccaca gaatgtcttc tcctagctgt gatggcctat 360 gatcgctatg ctgctgtctg tcaacctctt tactacacaa tagtaatgca ccctcagctt 420 tgccagaaga tggttctcac tgcctggtta ggtggtcttg gaagtgcctt aattctttgc 480 tccttgactt tgaagttgcc aagatgtggg catcgggagg ttgataattt tatttgtgag 540 atgccagcat tgctcaagtt ggcttgtgtc tactcaaaag taattgaggt catcgtctat 600 gctcttgggg tgatatttct tctagtacct ctatcactaa ttctcatctc atatgcaatt 660 atcactcaag ctgtcatgag gatcaagtca acagcaaggt ggcataaggt ccttaatacc 720 tgtggttccc acctcacagt agtaactctg ttttacggaa caatcattta tatgtacatg 780 aagccacaga atagcacatc tgaagatgag gggaagttcc ttacactctt ttacacaatt 840 gtcacaccca cccttaaccc tctgatctac acattaagaa acaaagatgt gaagaatgca 900 gtaaagagaa tactgtatgt gagaaaatgt tcagcaaagt catga 945

<210> 2524 <211> 314 <212> PRT <213> Felis catus

<400> 2524 Met Asn Thr Asn 1 Asn 5 Gly Ser Ala Thr Ala Asp Phe Ile Leu Leu Gly 10 15 Phe Ser Asp Gln Pro Gln Val Glu His Ile Ile Ser Gly Val Val Phe 20 25 30 Ile Phe Tyr Ile Val Thr Leu Val Gly Asn Thr Ala Ile Ile Leu Val 35 40 45 Ser Asn Leu Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Ala Thr Ser Ile Ile Pro Gln Page 2802

069269_0225_SL.TXT

Met Leu Val Asn Leu Trp Ser Pro Thr Lys Ser Ile Thr Tyr Gly Gly 85 90 95 Cys Val Phe Gln Phe Phe Phe Ala Leu Asp Phe Gly Ala Thr Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Gln 115 120 125 Pro Leu Tyr Tyr Thr Ile Val Met His Pro Gln Leu Cys Gln Lys Met 130 135 140 Val Leu Thr Ala Trp Leu Gly Gly Leu Gly Ser Ala Leu Ile Leu Cys 145 150 155 160 Ser Leu Thr Leu Lys Leu Pro Arg Cys Gly His Arg Glu Val Asp Asn 165 170 175 Phe Ile Cys Glu Met Pro Ala Leu Leu Lys Leu Ala Cys Val Tyr Ser 180 185 190 Lys Val Ile Glu Val Ile Val Tyr Ala Leu Gly Val Ile Phe Leu Leu 195 200 205 Val Pro Leu Ser Leu Ile Leu Ile Ser Tyr Ala Ile Ile Thr Gln Ala 210 215 220 Val Met Arg Ile Lys Ser Thr Ala Arg Trp His Lys Val Leu Asn Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Tyr Met Tyr Met Lys Pro Gln Asn Ser Thr Ser Glu Asp Glu Gly Lys 260 265 270 Phe Leu Thr Leu Phe Tyr Thr Ile Val Thr Pro Thr Leu Asn Pro Leu

Page 2803

06926 9_0225_SL.TX T 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Asn Ala Val Lys Arg Ile 290 295 300 Leu Tyr Val Arg Lys Cys Ser Ala Lys Ser 305 310

<210> 2525 <211> 945 <212> DNA <213> Felis catus <400> 2525

atggacacaa ataatgaaag ttccactaca gacttcatcc tgctggggtt ttctgatctg 60 ccccaattag aacacatcat ctctggggtt gtcttcgtct tctatattat gactctagta 120 ggaaacacag ccatcatcct tgtatctaac ctagacagcc agctccatac tcccatgtat 180 ttcttcctat ccaatttgtc ttttctggac ctctgttatg caactagcat tatcccacag 240 atgctggtaa atctttgggg tccaacaaag tctattacct atggagggtg tgtgctccaa 300 ttcttttttg cccttgactt gggagccaca gaatgtcttc tcttggctgt gatggcctat 360 gatcgctatg ctgctgtctg tcaacctctt cactacacag tattaatgca ccctcagctt 420 tgccagaaga tggtgctcac tgcctggtta ggtggtcttg gcagtgcctt aatcgtttgt 480 tccttgactt tgaagttgcc aagatgtggg caccgggagg tggataattt tttctgtgag 540 atgccagcct tgctcaagat ggcttgtgtc tactcaaaag taattgagat tgttgtcttt 600 gctcttggag tgatatttct tctagcacct ctatcaataa ttttcatctc atatgcaatt 660 atcactcaag ctgtcatgag gatcaagtca acagcaaggt ggcataaggt ccttaataca 720 tgtggttccc acctcacagt agtaactctg ttttatggaa caatcattta tatgtacatg 780 aagccacaga atagcacatc tgaagatgaa gggaagttcc ttacactatt ttacacaatc 840 gtcacaccca cccttaaccc tctgatctac actttaagaa acaaagatgt gaagagtgca 900 gtaaagagaa tactgtgtga acgaaaatgg tcagcaaagt catga 945

<210> 2526 <211> 314

Page 2804

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 2526 Leu 15 Gly Met 1 Asp Thr Asn Asn Glu Ser Ser 5 Thr Thr 10 Asp Phe Ile Leu Phe Ser Asp Leu Pro Gln Leu Glu His Ile Ile Ser Gly Val Val Phe 20 25 30 Val Phe Tyr Ile Met Thr Leu Val Gly Asn Thr Ala Ile Ile Leu Val 35 40 45 Ser Asn Leu Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Ala Thr Ser Ile Ile Pro Gln 65 70 75 80 Met Leu Val Asn Leu Trp Gly Pro Thr Lys Ser Ile Thr Tyr Gly Gly 85 90 95 Cys Val Leu Gln Phe Phe Phe Ala Leu Asp Leu Gly Ala Thr Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Gln 115 120 125 Pro Leu His Tyr Thr Val Leu Met His Pro Gln Leu Cys Gln Lys Met 130 135 140 Val Leu Thr Ala Trp Leu Gly Gly Leu Gly Ser Ala Leu Ile Val Cys 145 150 155 160 Ser Leu Thr Leu Lys Leu Pro Arg Cys Gly His Arg Glu Val Asp Asn 165 170 175 Phe Phe Cys Glu Met Pro Ala Leu Leu Lys Met Ala Cys Val Tyr Ser 180 185 190

Page 2805

Lys Val Ile 195 Glu Ile Val Val 069269_0225_SL.TXT Phe Ala Leu Gly Val Ile 200 205 Phe Leu Leu Ala Pro Leu Ser Ile Ile Phe Ile Ser Tyr Ala Ile Ile Thr Gln Ala 210 215 220 Val Met Arg Ile Lys Ser Thr Ala Arg Trp His Lys Val Leu Asn Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Tyr Met Tyr Met Lys Pro Gln Asn Ser Thr Ser Glu Asp Glu Gly Lys 260 265 270 Phe Leu Thr Leu Phe Tyr Thr Ile Val Thr Pro Thr Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Ser Ala Val Lys Arg Ile 290 295 300 Leu Cys Glu Arg Lys Trp Ser Ala Lys Ser

305 310 <210> 2527 <211> 933 <212> DNA <213> Felis catus <400> 2527

atgaattggg ctaatgagag ctccgcaaga gagtttatac tacttggctt ctcagacagg 60 ccctggctac agatgcccct gtttgtgctt ctattaatat catatacatt caccatcttt 120 ggcaatgtgt ccatcatgat ggtgtgcatt ctggatccta aacttcatac acccatgtat 180 ttcttcctca ctaatctctc catcttagat ctgtgctata ccacaagcac agtccctcat 240 atgttgacaa atatttgtcg caacaaaaag accatcagct acggtggctg tgtagcacag 300 ctcatcatct tcctggccct gggagctact gagtgtctcc tcctggctgt catgtccttt 360 gacagatatg tggcagtctg caaacccctg cactatgtag ttattatgaa tcattggttc 420

Page 2806

069269_0225_SL.TXT

tgcttaaggg tggtagcctt ctcgtggttc actggctttg gtaattcagt gttgcagtct 480 tccttgaccc ttaacatgcc acgttgtggt cgccaggaag tggaccactt tttctgtgag 540 gtgcctgccc ttctcaagtt gtcgtgtgct gacacaaagc ctattgagtc tgagctcttt 600 ttctttagtg tattaattct gctaattcca gtgacattaa tcctcatttc ttatggcttt 660 atagctcaag cagtgttgag aatcaggtca gcagaaggac gacgaaaagc ttttgggaca 720 tgtgggtccc acatggttgt ggtcgctctc ttttttggta cagccatcta catgtatcta 780 caaccacctt catccacctc taaggactgg ggaaagatgg tttccctctt ctatgggatc 840 attacaccca tgttgaaccc ccttatctac agccttagaa ataaagatat gaaggaggcc 900 ttcaagaggg tgatgaaaaa aatctttttt ctg 933

<210> 2528 <211> 311 <212> PRT <213> Felis catus <400> 2528

Met Asn Trp Ala Asn Glu Ser Ser Ala Arg Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asp Arg Pro Trp Leu Gln Met Pro Leu Phe Val Leu Leu Leu 20 25 30 Ile Ser Tyr Thr Phe Thr Ile Phe Gly Asn Val Ser Ile Met Met Val 35 40 45 Cys Ile Leu Asp Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu Thr 50 55 60 Asn Leu Ser Ile Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro His 65 70 75 80 Met Leu Thr Asn Ile Cys Arg Asn Lys Lys Thr Ile Ser Tyr Gly Gly 85 90 95 Cys Val Ala Gln Leu Ile Ile Phe Leu Ala Leu Gly Ala Thr Glu Cys 100 105 110

Page 2807

069269_0225_SL.TXT

Leu Leu Leu 115 Ala Val Met Ser Phe Asp Arg Tyr Val Ala Val Cys Lys 120 125 Pro Leu His Tyr Val Val Ile Met Asn His Trp Phe Cys Leu Arg Val 130 135 140 Val Ala Phe Ser Trp Phe Thr Gly Phe Gly Asn Ser Val Leu Gln Ser 145 150 155 160 Ser Leu Thr Leu Asn Met Pro Arg Cys Gly Arg Gln Glu Val Asp His 165 170 175 Phe Phe Cys Glu Val Pro Ala Leu Leu Lys Leu Ser Cys Ala Asp Thr 180 185 190 Lys Pro Ile Glu Ser Glu Leu Phe Phe Phe Ser Val Leu Ile Leu Leu 195 200 205 Ile Pro Val Thr Leu Ile Leu Ile Ser Tyr Gly Phe Ile Ala Gln Ala 210 215 220 Val Leu Arg Ile Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe Gly Thr 225 230 235 240 Cys Gly Ser His Met Val Val Val Ala Leu Phe Phe Gly Thr Ala Ile 245 250 255 Tyr Met Tyr Leu Gln Pro Pro Ser Ser Thr Ser Lys Asp Trp Gly Lys 260 265 270 Met Val Ser Leu Phe Tyr Gly Ile Ile Thr Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Glu Ala Phe Lys Arg Val 290 295 300 Met Lys Lys Ile Phe Phe Leu

305 310

Page 2808

069269_0225_SL.TXT <210> 2529 <211> 945 <212> DNA <213> Felis catus <400> 2529

atggacacaa acaacggaag ttcaataaca gatttcatcc tgctggggtt ttctgattgg 60 ccccaattag aacacatcat ctctgggatt gtcttcatct tctatattgt gactctggta 120 ggaaacacaa ccatcattct tgtatctaac ctagacagcc agctccatac tcccatgtat 180 ttcttcctat ccaatttgtc ttttctggat ctctgttatg caactagcat catcccacag 240 atgttggtta atctatgggg tccaacaaag tctattacct atggaggatg tgtgctccaa 300 ttcttctttg cccttgactt gggagccaca gaatgtcttc tcttggctgt gatggcctat 360 gaccgctatg ctgctgtttg tcaacctctt tactacacaa taataatgca ccctcagctt 420 tgccagaaga tggtgctaac cgcctggtta ggtggtcttg gtagtgcctt cattctttgc 480 tccctgactt tgaagttgcc aagatgtggg caccgggagg tcgataattt tttctgtgag 540 atgccagcct tgctcaagat ggcttgtgtc tactcaaaag taattgagat tgtagtcttt 600 gctcttggag tgatatttct tctagtacct ctgtcactaa ttctcatctc atatgcaatt 660 atcactcaag ctgttgtgag gatcaagtca acagcaaggt ggcataaggt ccttaataca 720 tgcggttccc acctcacagt agtaactctc ttttatggaa cagtcattta tatgtacatg 780 aagccacaga atagcacaac ccaagatgag gggaagtttc ttactctctt ttacacaatc 840 gtcacaccca cccttaaccc tctaatctac actttaagaa acaaagatgt aaagagagca 900 ataaaaagaa tactgtatgt agaaaaatgg taaacaaagg catga 945

<210> 2530 <211> 310 <212> PRT <213> Felis catus <400> 2530

Met Asp Thr Asn Asn Gly Ser Ser Ile Thr Asp Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asp Trp Pro Gln Leu Glu His Ile Ile Ser Gly Ile Val Phe 20 25 30

Page 2809

069269_0225_SL.TXT

Ile Phe Tyr 35 Ile Val Thr Leu Val Gly Asn Thr Thr Ile Ile Leu Val 40 45 Ser Asn Leu Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Ala Thr Ser Ile Ile Pro Gln 65 70 75 80 Met Leu Val Asn Leu Trp Gly Pro Thr Lys Ser Ile Thr Tyr Gly Gly 85 90 95 Cys Val Leu Gln Phe Phe Phe Ala Leu Asp Leu Gly Ala Thr Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Gln 115 120 125 Pro Leu Tyr Tyr Thr Ile Ile Met His Pro Gln Leu Cys Gln Lys Met 130 135 140 Val Leu Thr Ala Trp Leu Gly Gly Leu Gly Ser Ala Phe Ile Leu Cys 145 150 155 160 Ser Leu Thr Leu Lys Leu Pro Arg Cys Gly His Arg Glu Val Asp Asn 165 170 175 Phe Phe Cys Glu Met Pro Ala Leu Leu Lys Met Ala Cys Val Tyr Ser 180 185 190 Lys Val Ile Glu Ile Val Val Phe Ala Leu Gly Val Ile Phe Leu Leu 195 200 205 Val Pro Leu Ser Leu Ile Leu Ile Ser Tyr Ala Ile Ile Thr Gln Ala 210 215 220 Val Val Arg Ile Lys Ser Thr Ala Arg Trp His Lys Val Leu Asn Thr 225 230 235 240

Page 2810

069269_0225_SL.TXT

Cys Gly Ser His Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Val Ile 245 250 255 Tyr Met Tyr Met Lys Pro Gln Asn Ser Thr Thr Gln Asp Glu Gly Lys 260 265 270 Phe Leu Thr Leu Phe Tyr Thr Ile Val Thr Pro Thr Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Arg Ala Ile Lys Arg Ile 290 295 300 Leu Tyr Val Glu Lys Trp

305 310 <210> 2531 <211> 942 <212> DNA <213> Felis catus <400> 2531 atgggccaaa acaattacac ttctctgcac ggttttattc tgcttggttt ctcagaccat 60 ccccaaactg gagatggtcc tatccaggag ttgtcactct cttctacttc attatgtggg 120 tgggtaacac agccatcatc cttgcatctt tcctggattc ccatctccac acaccgatgt 180 attttttcct caggaactta tctttcctgg atctatgttt cacaaccagc atcatccctc 240 agatgctcgt taatttgtgg ggacctgaca agaccatcag ctatgtgggc tgtgtcactc 300 aactctacgt ttatatgtgg ttgggttcca ctgagtgtct cctcctcgct gttatgtcct 360 atgatcgttt cacagctatt tgtaagcccc tgcattattt ggtaattatg aatccacatc 420 tctgtctcaa gatgataatc acagtctgga gcattagttt ggctgtttct gtattattat 480 gtacactcac cctgaatttg cctcgatgtg gaaacaacct tctggaccat ttcttgtgtg 540 agttgccagc tatgatcaag atagcttgta tagacaccac gacagttgaa atgtctgttt 600 ttgctttggg cattgtcatt gtccttacac cactcggcct tattcttata tcctatggct 660 acatcgccaa agctgtgctg agaataaagt caaaagaagg ccaacaaaaa gcaattaata 720

Page 2811

069269_0225_SL.TXT cctgtggatc tcatctcact gtcgtgtcca tcttctatgg aactattatc tacatgtacc ttcaaccagg taacagtgcc tccaaagacc agggaaagtt cctcaccctc ttttacacga tcatcactcc aagtcttaac ccactcattt ataccctgcg gaacaaggac atgaagaacg cattgaggaa gctggtgaga gtcgactgtg aatctacaaa at

780

840

900

942 <210> 2532 <211> 314 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (314)..(314) <223> Any amino acid <400> 2532

Gly Pro Lys Gln Leu His Phe Ser Ala Arg Phe Tyr Ser Ala Trp Phe 1 5 10 15 Leu Arg Pro Ser Pro Asn Trp Arg Trp Ser Tyr Pro Gly Val Val Thr 20 25 30 Leu Phe Tyr Phe Ile Met Trp Val Gly Asn Thr Ala Ile Ile Leu Ala 35 40 45 Ser Phe Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Thr Thr Ser Ile Ile Pro Gln 65 70 75 80 Met Leu Val Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Val Gly 85 90 95 Cys Val Thr Gln Leu Tyr Val Tyr Met Trp Leu Gly Ser Thr Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ser Tyr Asp Arg Phe Thr Ala Ile Cys Lys 115 120 125

Page 2812

069269_0225_SL.TXT

Pro Leu 130 His Tyr Leu Val Ile Met Asn Pro 135 His Leu 140 Cys Leu Lys Met Ile Ile Thr Val Trp Ser Ile Ser Leu Ala Val Ser Val Leu Leu Cys 145 150 155 160 Thr Leu Thr Leu Asn Leu Pro Arg Cys Gly Asn Asn Leu Leu Asp His 165 170 175 Phe Leu Cys Glu Leu Pro Ala Met Ile Lys Ile Ala Cys Ile Asp Thr 180 185 190 Thr Thr Val Glu Met Ser Val Phe Ala Leu Gly Ile Val Ile Val Leu 195 200 205 Thr Pro Leu Gly Leu Ile Leu Ile Ser Tyr Gly Tyr Ile Ala Lys Ala 210 215 220 Val Leu Arg Ile Lys Ser Lys Glu Gly Gln Gln Lys Ala Ile Asn Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ser Ile Phe Tyr Gly Thr Ile Ile 245 250 255 Tyr Met Tyr Leu Gln Pro Gly Asn Ser Ala Ser Lys Asp Gln Gly Lys 260 265 270 Phe Leu Thr Leu Phe Tyr Thr Ile Ile Thr Pro Ser Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Met Lys Asn Ala Leu Arg Lys Leu 290 295 300 Val Arg Val Asp Cys Glu Ser Thr Lys Xaa

305 310 <210> 2533 <211> 838 <212> DNA

Page 2813

069269_0225_SL.TXT <213> Felis catus <400> 2533 ctacacgttg acactgttgg gaaatattgc tattattctg gtttctcaac tagattccca 60 actccaaagt cctatgtatt tcttcctcac aaacctctcc tttttggacc tctgtttcac 120 caccacgact gtaccccaaa tgctgttcaa cttgggaggc tccaacaaga acatcactta 180 tataggctgt atggtgcagg cctatatatt tcactggctg ggctgtactg aatgtgtcct 240 gcttggcatc atggccttag accgctatgt ggctgtgtgt aagcctctga ggtactctgt 300 aatcatggac cacaagcact gccagcagct ctccagctca gcctggctca ttggtctggc 360 aaattcactg ctgcagtcga cgctcacagt ccagctgccc ctgtgtggga atcaggagct 420 agatcacttc ttttgtgagc tgcccgggct tattaagatg gcttgcacgg acaccacaat 480 caatgaggtc actttagcag tggtggccac ctttctgata atgggacccc tctccatgat 540 tcttgtctct tacagttgta ttgcccaagc tgtatttcga atcccttctg ctgataggag 600 acttaaggcc ttcagcactt gttcatcaca cttactggtg gtgtctttat tttatggccc 660 cggcatctac atctacatgc agccctcagg ggacagccct caagacctta ccaaagctct 720 gacactgttt tactgtgtta ttactcctat ggccaaccca ttcatctaca ccttgaggaa 780 caaggatgtt aaaggagctt tgaggagatt tctgaggagt gccattttgt ccgaaaga 838 <210> 2534 <211> 279 <212> PRT <213> Felis catus <400> 2534

Tyr Thr Leu Thr Leu Leu Gly Asn Ile Ala Ile Ile Leu Val Ser Gln 1 5 10 15 Leu Asp Ser Gln Leu Gln Ser Pro Met Tyr Phe Phe Leu Thr Asn Leu 20 25 30 Ser Phe Leu Asp Leu Cys Phe Thr Thr Thr Thr Val Pro Gln Met Leu 35 40 45 Phe Asn Leu Gly Gly Ser Asn Lys Asn Ile Thr Tyr Ile Gly Cys Met

50 55 60

Page 2814

069269_0225_SL.TXT

Val 65 Gln Ala Tyr Ile Phe His Trp Leu Gly Cys Thr Glu Cys Val Leu 70 75 80 Leu Gly Ile Met Ala Leu Asp Arg Tyr Val Ala Val Cys Lys Pro Leu 85 90 95 Arg Tyr Ser Val Ile Met Asp His Lys His Cys Gln Gln Leu Ser Ser 100 105 110 Ser Ala Trp Leu Ile Gly Leu Ala Asn Ser Leu Leu Gln Ser Thr Leu 115 120 125 Thr Val Gln Leu Pro Leu Cys Gly Asn Gln Glu Leu Asp His Phe Phe 130 135 140 Cys Glu Leu Pro Gly Leu Ile Lys Met Ala Cys Thr Asp Thr Thr Ile 145 150 155 160 Asn Glu Val Thr Leu Ala Val Val Ala Thr Phe Leu Ile Met Gly Pro 165 170 175 Leu Ser Met Ile Leu Val Ser Tyr Ser Cys Ile Ala Gln Ala Val Phe 180 185 190 Arg Ile Pro Ser Ala Asp Arg Arg Leu Lys Ala Phe Ser Thr Cys Ser 195 200 205 Ser His Leu Leu Val Val Ser Leu Phe Tyr Gly Pro Gly Ile Tyr Ile 210 215 220 Tyr Met Gln Pro Ser Gly Asp Ser Pro Gln Asp Leu Thr Lys Ala Leu 225 230 235 240 Thr Leu Phe Tyr Cys Val Ile Thr Pro Met Ala Asn Pro Phe Ile Tyr 245 250 255 Thr Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Arg Phe Leu Arg 260 265 270

Page 2815

069269_0225_SL.TXT

Ser Ala Ile Leu Ser Glu Arg 275 <210> 2535 <211> 749 <212> DNA <213> Felis catus <400> 2535

aaaagaatga ccaaggcaag atgagatcca caggtggaga aagctttgag ttttccttgg 60 gtggaaggga ttttcatcac agcagagatg atgaggctgt aggatgccag gatacacccc 120 gaaggtaccg caaaaataag ccccactgca gccagaacta tgaactgatt gagactggtg 180 ttggaacagg agagggggag gagagagttg atatcacaga agaaatggtg gatcatgttg 240 ttagagcaga agtgcagacg ggcgagcatg agggtgtgca agaggggatt caaagtggca 300 aggatccatg gcacagccac cagagaggca caaaggcact gggtcatgat ggtggagtaa 360 cgcaaaggat gacagatggc cacaaaacgg tcatatgcca tcactgtgag aaggaaattg 420 tccatgttgg caaacatcat acagaaatac atctgagcca ggcagccagg ataggagatg 480 gtctgagtct gtgcctggat gttcagcagc atcttgggaa ctgtagatga aggcaggcag 540 aggtctactg cagacagatt ggcaaggaag aaatacatgg gtgtgtggag gcggtggtct 600 gagacaatag ccagcaagat gagcaagttt ccaagcagcc ctgttaagta gaggcacagg 660 aaaagtgcaa agaggagagc ctgcgactcg ggccatcttg aaaaggccaa gaggagaaat 720 tcggagacac tggtttggtt tccttgttc 749

<210> 2536 <211> 250 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (250)..(250) <223> Any amino acid <400> 2536

Glu Gln Gly Asn Gln Thr Ser Val Ser Glu Phe Leu Leu Leu Ala Phe Page 2816

0 6926 ι9_02 25_S iL.TX T 1 5 10 15 Ser Arg Trp Pro Glu Ser Gln Ala Leu Leu Phe Ala Leu Phe Leu Cys 20 25 30 Leu Tyr Leu Thr Gly Leu Leu Gly Asn Leu Leu Ile Leu Leu Ala Ile 35 40 45 Val Ser Asp His Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn 50 55 60 Leu Ser Ala Val Asp Leu Cys Leu Pro Ser Ser Thr Val Pro Lys Met 65 70 75 80 Leu Leu Asn Ile Gln Ala Gln Thr Gln Thr Ile Ser Tyr Pro Gly Cys 85 90 95 Leu Ala Gln Met Tyr Phe Cys Met Met Phe Ala Asn Met Asp Asn Phe 100 105 110 Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro 115 120 125 Leu Arg Tyr Ser Thr Ile Met Thr Gln Cys Leu Cys Ala Ser Leu Val 130 135 140 Ala Val Pro Trp Ile Leu Ala Thr Leu Asn Pro Leu Leu His Thr Leu 145 150 155 160 Met Leu Ala Arg Leu His Phe Cys Ser Asn Asn Met Ile His His Phe 165 170 175 Phe Cys Asp Ile Asn Ser Leu Leu Pro Leu Ser Cys Ser Asn Thr Ser 180 185 190 Leu Asn Gln Phe Ile Val Leu Ala Ala Val Gly Leu Ile Phe Ala Val 195 200 205 Pro Ser Gly Cys Ile Leu Ala Ser Tyr Ser Leu Ile Ile Ser Ala Val

Page 2817

06926 9_02 25_S L.TXT 210 215 220 Met Lys Ile Pro Ser Thr Gln Gly Lys Leu Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Ser His Leu Ala Leu Val Ile Leu Xaa 245 250

<210> 2537 <211> 959 <212> DNA <213> Felis catus <400> 2537

atggacccga aaaatggaag ttctttcact ggctttatcc tgctgggttt ctctgaccgg 60 cctcagctgg agcgagtcct ctttgtggtt cttctgatct tctatctgct caccctgctg 120 ggaaacacaa ccatcattgc gttgtcccac ctggacccac acctgcagac tcccatgtac 180 tttttcctgt ccaacctaag ctttctggac ctgtgttaca tgaccagcac tgttcctcag 240 ctgctggttc atctcagggg agcagacaag tctatctcct ttgctggctg tgtagctcag 300 ctgtttgtct ctctagggtt gggatgcaca gaatgcattc tgttaggggt gatggcattt 360 gaccgctatg cagccgtctg caggcccctg cactacacag tgatcatgca cccccgtctc 420 tgtgccctga tggcctctgc atcatgggtc acgggttttg cctactcctc attgcagacg 480 gtgctcattt ttcttgtacc actttgtggg aagaataaaa tagaccactt cttttgtgag 540 gttcccccat tgctcaagct tgcctgtgtt gacaccactg tgtatgagtc tgagatctta 600 tttttcagta tggtctttct tttcatacct gtggcattaa tcacattctc ctatggtcag 660 atcatcagag cagtgttaag aataaagtca gccgcaggac agaggaaagt gtttgggaca 720 tgtgggtccc acctcactgt ggtctccctg ttctatggca cggccatcta tgcttacctg 780 cagcccagca acaaccactc ccaggatcag ggcaagttca tttctctctt ctacaccatt 840 gtcaccccca cagtcaaccc cttcatatat accctgcgga acaaagatgt gacgggtgca 900 atgaagaagg tgttctgttg ggactatgac tccagatgac tggggtgaag actctttga 959

<210> 2538 <211> 312

Page 2818

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 2538 Leu 15 Gly Met 1 Asp Pro Lys Asn Gly Ser Ser 5 Phe Thr 10 Gly Phe Ile Leu Phe Ser Asp Arg Pro Gln Leu Glu Arg Val Leu Phe Val Val Leu Leu 20 25 30 Ile Phe Tyr Leu Leu Thr Leu Leu Gly Asn Thr Thr Ile Ile Ala Leu 35 40 45 Ser His Leu Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Met Thr Ser Thr Val Pro Gln 65 70 75 80 Leu Leu Val His Leu Arg Gly Ala Asp Lys Ser Ile Ser Phe Ala Gly 85 90 95 Cys Val Ala Gln Leu Phe Val Ser Leu Gly Leu Gly Cys Thr Glu Cys 100 105 110 Ile Leu Leu Gly Val Met Ala Phe Asp Arg Tyr Ala Ala Val Cys Arg 115 120 125 Pro Leu His Tyr Thr Val Ile Met His Pro Arg Leu Cys Ala Leu Met 130 135 140 Ala Ser Ala Ser Trp Val Thr Gly Phe Ala Tyr Ser Ser Leu Gln Thr 145 150 155 160 Val Leu Ile Phe Leu Val Pro Leu Cys Gly Lys Asn Lys Ile Asp His 165 170 175 Phe Phe Cys Glu Val Pro Pro Leu Leu Lys Leu Ala Cys Val Asp Thr 180 185 190

Page 2819

Thr Val Tyr 195 Glu Ser Glu Ile 069269_0225_SL.TXT Leu Phe Phe Ser Met Val 200 205 Phe Leu Phe Ile Pro Val Ala Leu Ile Thr Phe Ser Tyr Gly Gln Ile Ile Arg Ala 210 215 220 Val Leu Arg Ile Lys Ser Ala Ala Gly Gln Arg Lys Val Phe Gly Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Thr Ala Ile 245 250 255 Tyr Ala Tyr Leu Gln Pro Ser Asn Asn His Ser Gln Asp Gln Gly Lys 260 265 270 Phe Ile Ser Leu Phe Tyr Thr Ile Val Thr Pro Thr Val Asn Pro Phe 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Thr Gly Ala Met Lys Lys Val 290 295 300 Phe Cys Trp Asp Tyr Asp Ser Arg

305 310 <210> 2539 <211> 945 <212> DNA <213> Felis catus <400> 2539

gatggaccag aaaaatggaa gttctttcac tggctttatc ctgctgggtt tctctgaccg 60 gcctcagctg gagcgagtcc tctttgtggt tcttctgatc ttctatctgc tcaccctgct 120 gggaaacaca agcatcattg cgttgtcccg cctggaccca cacctgcaga ctcccatgta 180 ctttttcctg tccaacctaa gctttctgga cctgtgttac acgaccagca ctgttcctca 240 gctgctggtt catctcaggg gagcagacaa gtctatctcc ttcactggct gtgtagctca 300 gctgttcatt gctctagggt tgggatgcac agaatgcatt ctgttagggg tgatggcatt 360 tgaccgctac gcagccgtct gcaggcccct gcactacaca gtgatcatgc acccccgtct 420

Page 2820

069269_0225_SL.TXT

ctgtgccctg atggcttctg catcatggtt cattggtttt gtcaactcct cattgcagac 480 ggtactcatc ttccttgtac cactttgtgg gagaaataaa atagaccact tcttttgtga 540 gatcccccca ctgctcaagc ttgcctgtgt tgacaccact gtgaatgaat ctgaggcctt 600 ctttgccagt atgatcattc tcctcatacc tgtggcatta atcacattct cctatagtcg 660 gattgtcaag gtggtcttag caataaagtc agcttcgggg cagaggaaag catttgggac 720 atgtgggtcc cacctcacgg tggtctctct gttctatggc tcggccatct atgcttacct 780 ccaacccagc aacaaccatt cccaggatca gggcaagttc gtttctcttt tctacaccat 840 tgtcaccccc atggccaacc ccttcatata taccctgcgg aacaaggatg tgatgggagc 900 aatgaaaaaa gtgttctgta ggagctttga ctccagatga ctggg 945

<210> 2540 <211> 312 <212> PRT <213> Felis catus <400> 2540

Met Asp Gln Lys Asn Gly Ser Ser Phe Thr Gly Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asp Arg Pro Gln Leu Glu Arg Val Leu Phe Val Val Leu Leu 20 25 30 Ile Phe Tyr Leu Leu Thr Leu Leu Gly Asn Thr Ser Ile Ile Ala Leu 35 40 45 Ser Arg Leu Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro Gln 65 70 75 80 Leu Leu Val His Leu Arg Gly Ala Asp Lys Ser Ile Ser Phe Thr Gly 85 90 95 Cys Val Ala Gln Leu Phe Ile Ala Leu Gly Leu Gly Cys Thr Glu Cys 100 105 110

Page 2821

069269_0225_SL.TXT

Ile Leu Leu 115 Gly Val Met Ala Phe Asp Arg Tyr Ala Ala Val Cys Arg 120 125 Pro Leu His Tyr Thr Val Ile Met His Pro Arg Leu Cys Ala Leu Met 130 135 140 Ala Ser Ala Ser Trp Phe Ile Gly Phe Val Asn Ser Ser Leu Gln Thr 145 150 155 160 Val Leu Ile Phe Leu Val Pro Leu Cys Gly Arg Asn Lys Ile Asp His 165 170 175 Phe Phe Cys Glu Ile Pro Pro Leu Leu Lys Leu Ala Cys Val Asp Thr 180 185 190 Thr Val Asn Glu Ser Glu Ala Phe Phe Ala Ser Met Ile Ile Leu Leu 195 200 205 Ile Pro Val Ala Leu Ile Thr Phe Ser Tyr Ser Arg Ile Val Lys Val 210 215 220 Val Leu Ala Ile Lys Ser Ala Ser Gly Gln Arg Lys Ala Phe Gly Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Tyr Ala Tyr Leu Gln Pro Ser Asn Asn His Ser Gln Asp Gln Gly Lys 260 265 270 Phe Val Ser Leu Phe Tyr Thr Ile Val Thr Pro Met Ala Asn Pro Phe 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Met Gly Ala Met Lys Lys Val 290 295 300 Phe Cys Arg Ser Phe Asp Ser Arg

305 310

Page 2822

069269_0225_SL.TXT <210> 2541 <211> 961 <212> DNA <213> Felis catus <400> 2541

aggatggacc cgaaaaatgg aagttctttc actggcttta tcctgctggg tttctctgac 60 cggcctcagc tggagcgagt cctctttgtg gttcttctga tcttctatct gctcaccctg 120 ctgggaaaca caagcatcat tgcgttgtcc ctcctggacc cacacctgca gactcccatg 180 tactttttcc tgtccaacct aagctttctg gacctgtgtt acacgaccag cactgttcct 240 cagctgctgg ttcatctcag gggagcagac aagtctatct ctttcggtgg ttgtgtagct 300 cagctgttcg tctctctagg gttggcatct acagaatgca ttctgttagg ggtgatggca 360 tttgaccgct acgcagccgt ctgcaggccc ctgcactaca cagtgatcat gcacccccgt 420 ctctgtgccc tgatggcttc tgcatcgtgg ttccttggtt ttgtcaactc ctcattgcac 480 acggtgctca ccttccttgt accactatgt gggagaaata aaatagagca cttctattgt 540 gaggtccccc cactgctcaa gcttgcctgt gttgacacca ctgtgaatga gtctgagctc 600 tttgtcagtg tgatcattct cctcatacct gtggctttaa tcacgttctc ctatggtcag 660 attgtcaagg cagtgttaag aataaagtca gcttcagggc agaggaaagc ttttgggact 720 tgtgggtccc acctcacagt ggtctccctg ttctacggca caggcatcta catttacctc 780 cagcccagca acaactactc ccaggatcag ggcaagttcg tttctctctt ctacaccatc 840 gtcaccccca tggtcaatcc ctttatatat acccttcgga acaaggatgt gactggagca 900 atgaagaagg cgctttgtag gggctatgac tccagatgac tcggtacaga agaccctgtg 960

a 961 <210> 2542 <211> 311 <212> PRT <213> Felis catus <400> 2542

Met Asp Pro Lys Asn Gly Ser Ser Phe Thr Gly Phe Ile Leu Leu Gly 1 5 10 15

Page 2823

069269_0225_SL.TXT

Phe Ser Asp Arg 20 Pro Gln Leu Glu Arg Val Leu Phe Val Val Leu Leu 25 30 Ile Phe Tyr Leu Leu Thr Leu Leu Gly Asn Thr Ser Ile Ile Ala Leu 35 40 45 Ser Leu Leu Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro Gln 65 70 75 80 Leu Leu Val His Leu Arg Gly Ala Asp Lys Ser Ile Ser Phe Gly Gly 85 90 95 Cys Val Ala Gln Leu Phe Val Ser Leu Gly Leu Ala Ser Thr Glu Cys 100 105 110 Ile Leu Leu Gly Val Met Ala Phe Asp Arg Tyr Ala Ala Val Cys Arg 115 120 125 Pro Leu His Tyr Thr Val Ile Met His Pro Arg Leu Cys Ala Leu Met 130 135 140 Ala Ser Ala Ser Trp Phe Leu Gly Phe Val Asn Ser Ser Leu His Thr 145 150 155 160 Val Leu Thr Phe Leu Val Pro Leu Cys Gly Arg Asn Lys Ile Glu His 165 170 175 Phe Tyr Cys Glu Val Pro Pro Leu Leu Lys Leu Ala Cys Val Asp Thr 180 185 190 Thr Val Asn Glu Ser Glu Leu Phe Val Ser Val Ile Ile Leu Leu Ile 195 200 205 Pro Val Ala Leu Ile Thr Phe Ser Tyr Gly Gln Ile Val Lys Ala Val 210 215 220

Page 2824

Leu 225 Arg Ile Lys Ser Ala 230 Ser 069269_0225_SL.TXT Gly Gln Arg Lys Ala Phe 235 Gly Thr Cys 240 Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Thr Gly Ile Tyr 245 250 255 Ile Tyr Leu Gln Pro Ser Asn Asn Tyr Ser Gln Asp Gln Gly Lys Phe 260 265 270 Val Ser Leu Phe Tyr Thr Ile Val Thr Pro Met Val Asn Pro Phe Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Asp Val Thr Gly Ala Met Lys Lys Ala Leu 290 295 300 Cys Arg Gly Tyr Asp Ser Arg

305 310 <210> 2543 <211> 957 <212> DNA <213> Felis catus <400> 2543

gatggacctg aaaaatggaa gttctttcac tggctttatc ctgctgggtt tctctgaccg 60 gcctcagctg gaacaagtcc tctttgtggt tcttctgatc ttctatctgc tcaccctgct 120 gggaaacaca agcatcattg cattgtcccg cctggaccca cacctgcaga ctcccatgta 180 ctttttcctc tccaacctaa gctttctgga cctgtgttat acgaccagca ctgttcctca 240 gctactggtt gatctcaggg gaacagacaa gtctatctcc tttgctggct gtgtagctca 300 gctcttcgtg tctctatggt tgggatccac agaatgcatt ctgttggggg tgatggcgtt 360 tgatcgctac gcagccgtct gcaggcccct gcactacaca gtgatcatgc acccccgtct 420 ctgtgccctg atggcttctg catcgtggtt cattggtttt gtcaattcct cattgcacac 480 ggtgctcacc ttccttgtac cactttgtgg gagaaataaa atagaccact tcttttgtga 540 gatcccctca ctgctcaagc ttgcctgtgt tgacaccact gggaatgaga atgagctctt 600 ctctgtcagt gtgatgattc ttttgatacc tgtggcatta atcacattct cctatggtca 660

Page 2825

069269_0225_SL.TXT gattgtcagg gtggtcttgg caataaagtc agcttcaggg cagaggaaag cgtttgggac atgtgggtcc cacctcactg tggtttccct gttctacggc acaggcatct acatttacct ccagcccagc aacaactact cccaggatca gggcaagttc atttctctct tctacaccat tgtcaccccc atggtcaacc ctgttatata taccctgcgg aacaaggatg tgatgggagc aatgaggaag gtgttgtgta ggggctatga ctccagatga ctgagggaag acccttt

720

780

840

900

957 <210> 2544 <211> 312 <212> PRT <213> Felis catus <400> 2544

Met Asp Leu 1 Lys Asn Gly Ser Ser 5 Phe Thr Gly Phe Ile Leu Leu Gly 10 15 Phe Ser Asp Arg Pro Gln Leu Glu Gln Val Leu Phe Val Val Leu Leu 20 25 30 Ile Phe Tyr Leu Leu Thr Leu Leu Gly Asn Thr Ser Ile Ile Ala Leu 35 40 45 Ser Arg Leu Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro Gln 65 70 75 80 Leu Leu Val Asp Leu Arg Gly Thr Asp Lys Ser Ile Ser Phe Ala Gly 85 90 95 Cys Val Ala Gln Leu Phe Val Ser Leu Trp Leu Gly Ser Thr Glu Cys 100 105 110 Ile Leu Leu Gly Val Met Ala Phe Asp Arg Tyr Ala Ala Val Cys Arg 115 120 125 Pro Leu His Tyr Thr Val Ile Met His Pro Arg Leu Cys Ala Leu Met 130 135 140

Page 2826

069269_0225_SL.TXT

Ala Ser Ala Ser Trp Phe Ile Gly Phe Val Asn Ser Ser Leu His Thr 145 150 155 160 Val Leu Thr Phe Leu Val 165 Pro Leu Cys Gly Arg Asn 170 Lys Ile Asp His 175 Phe Phe Cys Glu Ile Pro 180 Ser Leu Leu Lys Leu Ala 185 Cys Val Asp Thr 190 Thr Gly Asn Glu Asn Glu 195 Leu Phe 200 Ser Val Ser Val Met Ile Leu Leu 205 Ile Pro 210 Val Ala Leu Ile Thr Phe 215 Ser Tyr Gly Gln 220 Ile Val Arg Val Val Leu 225 Ala Ile Lys Ser 230 Ala Ser Gly Gln Arg Lys 235 Ala Phe Gly Thr 240 Cys Gly Ser His Leu Thr 245 Val Val Ser Leu Phe Tyr 250 Gly Thr Gly Ile 255 Tyr Ile Tyr Leu Gln Pro 260 Ser Asn Asn Tyr Ser Gln 265 Asp Gln Gly Lys 270 Phe Ile Ser Leu Phe Tyr 275 Thr Ile 280 Val Thr Pro Met Val Asn Pro Val 285 Ile Tyr Thr Leu Arg Asn 290 Leu Cys Arg Gly Tyr Asp 305 310 <210> 2545 <211> 959 <212> DNA <213> Felis catus <400> 2545 Lys Asp 295 Ser Arg Val Met Gly Ala 300 Met Arg Lys Val aggatggacc cgaaaaatgg aagttctttc actggcttta tcctgctggg tttctctgac 60

Page 2827

069269_0225_SL.TXT

cggcctcagc tggagcgagt cctctttgtg gttcttctga tcttctatct gctcaccctg 120 ctgggaaaca caagcatcat tgcgttgtcc cgcctggacc cacacctgca gactcccatg 180 tacttttcct ctccaaccta agctttctgg acctgtgtta cacgaccagc actgttcctc 240 agctgctggt tcatctcagg ggagcagaca agtctatctc ctttgctgcc tgtgtagctc 300 agctgttcat tgctctaggg ttgggatgca cagaatgcat tctgttaggg gtgatggcat 360 ttgaccgcta cgcagccgtc tgcaggcccc tgcactacac agtgatcatg cacccccgtc 420 tctgtgccct gatggcttct gcatcgtggt tcattggttt tgccaactcc tcgttgcaga 480 cggtgctcac cttccttgta ccactttgtg ggagaaataa aatagaccac ttcttttgtg 540 aggtcccccc actgctcaag ctttcctgtg ttgacactac tgtgaatgaa tctgagctct 600 tctttgtcgg tgtgatcatt ctcctcatac ctgtggcatt aatcacgttc tcctatggtc 660 aaatcgtcag ggcagtgtta agaataaagt cagccgctgg acagaggaag gtgtttggga 720 catgtgggtc ccacctcact gtggtctccc tgttctatgg cacggccatc tatgcttacc 780 ttcagcccag caacaactac tcccaagatc tgggcaagtt catttctctc ttctacacca 840 ttgtcacccc catggtcaac cccttcatat ataccctgcg gaacaaggat gtgatgggag 900 cagtgagaaa ggtattgtgt aggggctatg actccagatg actgagggga agacccttt 959

<210> 2546 <211> 89 <212> PRT <213> Felis catus <400> 2546

Lys 1 Gly Ser Ser Pro Gln Ser Ser Gly Val Ile Ala Pro Thr Gln Tyr 5 10 15 Leu Ser His Cys Ser His His Ile Leu Val Pro Gln Gly Ile Tyr Glu 20 25 30 Gly Val Asp His Gly Gly Asp Asn Gly Val Glu Glu Arg Asn Glu Leu 35 40 45 Ala Gln Ile Leu Gly Val Val Val Ala Gly Leu Lys Val Ser Ile Asp

50 55 60

Page 2828

069269_0225_SL.TXT

Gly Arg Ala Ile Glu Gln Gly Asp His Ser Glu Val Gly Pro Thr Cys 65 70 75 80

Pro Lys His Leu Pro Leu Ser Ser Gly 85 <210> 2547 <211> 957 <212> DNA <213> Felis catus <400> 2547

gtggtacaaa aggatggacc ccaaaaatgg aagttctttc acgggcttta tcctgctggg 60 tttctctgac cggcctcagc tggagggtgt cctctttgtg gttcttctga tcttctatct 120 gctcaccctg ctgggaaaca caagcatcat tgcgttgtcc ctcctggacc cacacctgca 180 gactcccatg tactttttcc tctccaacct aagctttctg gacctgtgtt acacgaccag 240 cactgttcct caactgctgg ttcatctcag gggagcagac aagtctatct cctttgctgc 300 ctgtgtagct cagctgttca tctctctagg gttgggatcc acagaatgca ttctcttggg 360 ggtgatggca tttgaccgct atgcagccat atgcaggccc ctgcactaca cagtgatcat 420 gcacccccgt ctctgtgccc tgatggcttc tgcatcgtgg ttcattggtt ttgccaactc 480 ctcgttgcag acggtgctca ccttccttgt accactttgt gggagaaata aaatagacca 540 tttcctttgt gaggtccccc cactgctcaa gcttgcctgt gttgacacta ctgtgaatga 600 atctgagctc ttctttgtcg gtgtgatcat tctcctcata ccagtggcat taatcacgtt 660 ctcctatggt cgaatcgtca gggcagtgtt aagaataaag tcagccgcag gacagaggaa 720 agcctttggg acatgtgggt cccacctcac ggtggtctcc ctgttctatg gcacggccat 780 ctatgcttac ctccagccca gcaacaacta ctcccaggat cagggcaagt tcatttctct 840 cttctacgcc atcgtcaccc ccatggccaa cactttcata tatactctgc ggaacaagga 900 tgtgacggga gcaatgagga aggtgttctg tgggggcaat gactccagat gactggg 957

<210> 2548 <211> 312 <212> PRT

Page 2829

069269_0225_SL.TXT <213> Felis catus <400> 2548

Met Asp Pro Lys Asn Gly Ser Ser Phe Thr Gly Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asp Arg Pro Gln Leu Glu Gly Val Leu Phe Val Val Leu Leu 20 25 30 Ile Phe Tyr Leu Leu Thr Leu Leu Gly Asn Thr Ser Ile Ile Ala Leu 35 40 45 Ser Leu Leu Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro Gln 65 70 75 80 Leu Leu Val His Leu Arg Gly Ala Asp Lys Ser Ile Ser Phe Ala Ala 85 90 95 Cys Val Ala Gln Leu Phe Ile Ser Leu Gly Leu Gly Ser Thr Glu Cys 100 105 110 Ile Leu Leu Gly Val Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Thr Val Ile Met His Pro Arg Leu Cys Ala Leu Met 130 135 140 Ala Ser Ala Ser Trp Phe Ile Gly Phe Ala Asn Ser Ser Leu Gln Thr 145 150 155 160 Val Leu Thr Phe Leu Val Pro Leu Cys Gly Arg Asn Lys Ile Asp His 165 170 175 Phe Leu Cys Glu Val Pro Pro Leu Leu Lys Leu Ala Cys Val Asp Thr 180 185 190 Thr Val Asn Glu Ser Glu Leu Phe Phe Val Gly Val Ile Ile Leu Leu

Page 2830

195 069269_0225_SL.TXT 200 205 Ile Pro Val Ala Leu Ile Thr Phe Ser Tyr Gly Arg Ile Val Arg Ala 210 215 220 Val Leu Arg Ile Lys Ser Ala Ala Gly Gln Arg Lys Ala Phe Gly Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Thr Ala Ile 245 250 255 Tyr Ala Tyr Leu Gln Pro Ser Asn Asn Tyr Ser Gln Asp Gln Gly Lys 260 265 270 Phe Ile Ser Leu Phe Tyr Ala Ile Val Thr Pro Met Ala Asn Thr Phe 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Thr Gly Ala Met Arg Lys Val 290 295 300 Phe Cys Gly Gly Asn Asp Ser Arg

305 310 <210> 2549 <211> 957 <212> DNA <213> Felis catus <400> 2549

gatggacccg aaaaatggaa gttctttcac tggctttatc ctgctgggtt tctctgaccg 60 gcctcagctg gagcgagtcc tctttgtggt tcttctcatc ttctatctgc tcaccctgct 120 gggaaacaca agcatcattg cgttgtccct cctggaccca cacctgcaga ctcccatgta 180 ctttttcctg tccaacctaa gctttctgga cctgtgttac acgaccagca ctgttcctca 240 actgctggtt catctcaggg gagcagacaa gtccatctcc tttgcaggct gtgtagctca 300 gctgttcgtc gctctagggt tgggaggcac agaatgcatt ctgttggggg tgatggcatt 360 tgaccgctat gcagccgtct gcaggcccct gcactacaca gtgatcatgc acccccgtct 420 ctgtgccctg atggcttctg catcatggtt cattggcttt gccaactcct cattgcagac 480

Page 2831

069269_0225_SL.TXT

ggtgctcatc tttcttgtac cactttgtgg gagaaataaa atacaccact tcttttgtga 540 ggtcacccca ctgctcaagc ttgcctgtgt tgacaccact gggaatgaga atgagatctt 600 ctttgccagt gtgatcattc tcctcatacc tgtggcatta atcacgttct cctatggtca 660 gatagtcagg gcagtgttaa gaataaagtc agccacagga cagagaaaag cttttgggac 720 atgtgggtcc cacctcacgg tggtctccct gttctatggc tcggccatct atgcttacgt 780 ccagcccagc aacaactact cccaggatca gggcaagttc atttctctct tctacaccat 840 cgtcaccccc atggccaacc ccttcatata taccctgcgg aacaaggatg tgacgggtgc 900 aatgaagaag gtgttgtata ggggctatga ctccagatga ctgagggaag acccttt 957

<210> 2550 <211> 312 <212> PRT <213> Felis catus <400> 2550

Met Asp Pro Lys Asn Gly Ser Ser Phe Thr Gly Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asp Arg Pro Gln Leu Glu Arg Val Leu Phe Val Val Leu Leu 20 25 30 Ile Phe Tyr Leu Leu Thr Leu Leu Gly Asn Thr Ser Ile Ile Ala Leu 35 40 45 Ser Leu Leu Asp Pro His Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro Gln 65 70 75 80 Leu Leu Val His Leu Arg Gly Ala Asp Lys Ser Ile Ser Phe Ala Gly 85 90 95 Cys Val Ala Gln Leu Phe Val Ala Leu Gly Leu Gly Gly Thr Glu Cys 100 105 110

Page 2832

Ile Leu Leu 115 Gly Val Met Ala 069269_0225_SL.TXT Phe Asp Arg Tyr Ala Ala 120 125 Val Cys Arg Pro Leu His Tyr Thr Val Ile Met His Pro Arg Leu Cys Ala Leu Met 130 135 140 Ala Ser Ala Ser Trp Phe Ile Gly Phe Ala Asn Ser Ser Leu Gln Thr 145 150 155 160 Val Leu Ile Phe Leu Val Pro Leu Cys Gly Arg Asn Lys Ile His His 165 170 175 Phe Phe Cys Glu Val Thr Pro Leu Leu Lys Leu Ala Cys Val Asp Thr 180 185 190 Thr Gly Asn Glu Asn Glu Ile Phe Phe Ala Ser Val Ile Ile Leu Leu 195 200 205 Ile Pro Val Ala Leu Ile Thr Phe Ser Tyr Gly Gln Ile Val Arg Ala 210 215 220 Val Leu Arg Ile Lys Ser Ala Thr Gly Gln Arg Lys Ala Phe Gly Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ser Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Tyr Ala Tyr Val Gln Pro Ser Asn Asn Tyr Ser Gln Asp Gln Gly Lys 260 265 270 Phe Ile Ser Leu Phe Tyr Thr Ile Val Thr Pro Met Ala Asn Pro Phe 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Thr Gly Ala Met Lys Lys Val 290 295 300 Leu Tyr Arg Gly Tyr Asp Ser Arg

305 310

Page 2833

069269_0225_SL.TXT <210> 2551 <211> 930 <212> DNA <213> Felis catus <400> 2551

tcatggttgc ctccccaaga cccttttcag cgctcctttt acctccttgt tccttaaggt 60 gtatatgagt gggttcagca tgggggtgac caggttgtag aagagggtga gaaacttgcc 120 ctggtcttgg gaagcgctgt tcccgggctg catgtacatg tagatgatgc tcccgtagaa 180 cagagagacc acggtcaggt gggagctgca ggtgttgaat gccttgcggc gcccagcggc 240 cgactggatc ttcagcacgg ctgccgcgat gtggccgtag gacacgagaa tgagggcgag 300 gggcaggagg acgatgagga tggcgaaggt gaaggccagc atttccaccg cgcgggcgtc 360 cacacaagcc atcttgatca gtgctggcat ttcacagagg aagtggttga ccctgcgccg 420 gccacatctg gacagagtca ttacgagcgg ggacatgacg atggcattga ccagtccact 480 cccccaggcc acggccacca gtcgcaaaca cagctggggg tgcacaatga ccagatagtg 540 cagaggcctg cagaccgcgg cgaagcggtc ataggccatc acggccagga ggatgcactc 600 cacgctcccc acacagagga aggagaagag ctggaccgca cagccagcgt agctgatggt 660 cttgtcaggg ccccagagat tcaccagcat ctgcgggata cagctcgtac tgaagcagag 720 atctagaaag gagagattgg ccagaaagaa gtacattggg atatgaagtc gagggtctaa 780 aatacacaca aggattatgg ttgagtttcc caacacagcc actgaataca gagtgaaatt 840 gaccatgaag agtaccagct ccagcctcgg acgatcagag aagcccacta agataaaacc 900 atactgtgag ctgtcattgg atttttccat 930

<210> 2552 <211> 309 <212> PRT <213> Felis catus <400> 2552

Met Glu Lys Ser Asn Asp Ser Ser Gln Tyr Gly Phe Ile Leu Val Gly 1 5 10 15 Phe Ser Asp Arg Pro Arg Leu Glu Leu Val Leu Phe Met Val Asn Phe

20 25 30

Page 2834

069269_0225_SL.TXT

Thr Leu Tyr 35 Ser Val Ala Val Leu Gly Asn Ser Thr Ile Ile Leu Val 40 45 Cys Ile Leu Asp Pro Arg Leu His Ile Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Ser Thr Ser Cys Ile Pro Gln 65 70 75 80 Met Leu Val Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Ala Val Gln Leu Phe Ser Phe Leu Cys Val Gly Ser Val Glu Cys 100 105 110 Ile Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Ala Ala Val Cys Arg 115 120 125 Pro Leu His Tyr Leu Val Ile Val His Pro Gln Leu Cys Leu Arg Leu 130 135 140 Val Ala Val Ala Trp Gly Ser Gly Leu Val Asn Ala Ile Val Met Ser 145 150 155 160 Pro Leu Val Met Thr Leu Ser Arg Cys Gly Arg Arg Arg Val Asn His 165 170 175 Phe Leu Cys Glu Met Pro Ala Leu Ile Lys Met Ala Cys Val Asp Ala 180 185 190 Arg Ala Val Glu Met Leu Ala Phe Thr Phe Ala Ile Leu Ile Val Leu 195 200 205 Leu Pro Leu Ala Leu Ile Leu Val Ser Tyr Gly His Ile Ala Ala Ala 210 215 220 Val Leu Lys Ile Gln Ser Ala Ala Gly Arg Arg Lys Ala Phe Asn Thr 225 230 235 240

Page 2835

069269_0225_SL.TXT

Cys Ser Ser His Leu 245 Tyr Met Tyr Met 260 Gln Phe Leu Thr 275 Leu Phe Ile Tyr 290 Thr Leu Arg Leu Gly Arg Gln Pro

305

Thr Val Val Ser Leu 250 Phe Pro Gly Asn Ser 265 Ala Ser Tyr Asn Leu 280 Val Thr Pro Asn Lys 295 Glu Val Lys Gly

Tyr Gly Ser Ile 255 Ile Gln Asp Gln 270 Gly Lys Met Leu 285 Asn Pro Leu Ala Leu Lys Arg Val

300 <210> 2553 <211> 911 <212> DNA <213> Felis catus <400> 2553 atttcttgat taaggcggct tcttaagtgt gtatataagg ccatcttgcc ccggtccttg tgccatagaa gagtgacacc taccttccgc agattggatt tgagggtcag gggtattaga ccgtcgtgtc tacacaggac cttctttacg gccacagagc tgaaacccgt aatccaggac ctgagtaatg gagaggccga gaacacattc agtggccccc aactaattac cttcctggtg tgtagcaaag gtccaggagt cttgcaacta accttttaaa gggttcagca tgggtgcgat gagttggggg atggtggttg acaattagat gggagccaca ctcaacactg ctcgggcaat tggaacagca cgctcacaaa aacttgagca gagcagggac ggcagctgaa gggtcaaggc gcggccgcca gctggaggca caaatagcga caaacctatc aaagctagaa acatgaaaag ctgcataaat tgaccagcat gacagattgg taagaaaaaa ggcctccttt acctctttat gatcccatag aagagggaca caggtacaca gagatagcag tgtcccaaat gcctttcgtc aaaagcatac gatacgagga gaatagttca gcctcgtttg ttcacagagg aagtgatcca ggacaaccac actgagttgc cagcctctgg tgcatgacga aaaggacatg acggccagga ctgggccaca cagccgccat ttgtggaact gtacttgtgg gtacatgggg gtgtggagtt

120

180

240

300

360

420

480

540

600

660

720

780

Page 2836

069269_0225_SL.TXT tggggtccag gcgtgacact agaataatgg tcagattccc aaagatagtg gccacgtaag aaatgaagaa gaccacaaag agtgggagct ccagccgcgg tcgatctgag aaacctaaga gggtgaactc c

840

900

911 <210> 2554 <211> 304 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (304)..(304) <223> Any amino acid

<400> 2554 Gly Phe Ser Asp Arg Pro Arg Leu Glu Leu Pro Glu 1 Phe Thr Leu Leu 5 10 15 Leu Phe Val Val Phe Phe Ile Ser Tyr Val Ala Thr Ile Phe Gly Asn 20 25 30 Leu Thr Ile Ile Leu Val Ser Arg Leu Asp Pro Lys Leu His Thr Pro 35 40 45 Met Tyr Phe Phe Leu Thr Asn Leu Ser Leu Leu Asp Leu Cys Tyr Thr 50 55 60 Thr Ser Thr Val Pro Gln Met Leu Val Asn Leu Cys Ser Thr Arg Lys 65 70 75 80 Val Ile Ser Tyr Gly Gly Cys Val Ala Gln Leu Phe Met Phe Leu Ala 85 90 95 Leu Gly Ala Thr Glu Cys Val Leu Leu Ala Val Met Ser Phe Asp Arg 100 105 110 Phe Val Ala Ile Cys Arg Pro Leu His Tyr Ser Val Val Met His Gln 115 120 125

Page 2837

069269_0225_SL.TXT

Arg Leu Cys Leu Gln Leu Ala Ala Ala Ser Trp Ile Thr Gly Phe Ser 130 135 140 Asn Ser Val Trp Leu Ser Ala Leu Thr Leu Gln Leu Pro Leu Cys Gly 145 150 155 160 Arg Lys Glu Val Asp His Phe Leu Cys Glu Val Pro Ala Leu Leu Lys 165 170 175 Leu Ser Cys Val Asp Thr Thr Ala Asn Glu Ala Glu Leu Phe Phe Val 180 185 190 Ser Val Leu Phe His Leu Ile Pro Leu Thr Leu Ile Leu Val Ser Tyr 195 200 205 Ala Phe Ile Ala Arg Ala Val Leu Arg Ile Gln Ser Ala Glu Gly Arg 210 215 220 Arg Lys Ala Phe Gly Thr Cys Gly Ser His Leu Ile Val Val Ser Leu 225 230 235 240 Phe Tyr Gly Thr Ala Ile Ser Val Tyr Leu Gln Pro Pro Ser Pro Asn 245 250 255 Ser Lys Asp Arg Gly Lys Met Val Ser Leu Phe Tyr Gly Ile Ile Ala 260 265 270 Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Lys Asn Lys Glu Val Lys 275 280 285 Glu Ala Phe Lys Arg Leu Val Ala Arg Ala Ala Leu Ile Lys Lys Xaa

290 295 300 <210> 2555 <211> 913 <212> DNA <213> Felis catus <400> 2555 ggagttcatc ctcttgggtt tctcagaccg accatggctg gagctcccac tctttgtggt

Page 2838

069269_0225_SL.TXT

gttcctggtt tcctatatct tgactatctt tggcaatctg gcgataattg ccgtgtctca 120 tctggacccc aaactccaca cccccatgta ctttttcctt accaatctgt cactcctgga 180 cctttgctac accacaagca cagttccaca aatgctggtc aacatatgca gcaccaggaa 240 ggtaattagt tacggcggct gtgtggccca gcttttcatt ttcctggcct tgggttccac 300 tgaatgcctt ctcctggccg tcatgtcctt ggataggttt gtcgctatct gtcggcctct 360 ccattactca gtcatcatgc accagaggct gtgcctccag ctggcggccg cgtcctggat 420 tagcggcttt ggcaactcag tgttgcagtc caccttgacc cttcagctgc cgctctgtgg 480 ccgtaaagaa gtggatcact tcttctgtga agtccctgct ctgctcaagt tgtcctgtgt 540 ggacacaaca gcaaacgagg ctgaactatt ctttatcagt gtgctatttc ttttactacc 600 cctgaccctc atcctcgtat cgtatgcttt tattgcccga gcagtgttga gaatccagtc 660 tgcggaaggt agacgaaagg catttgggac gtgtggctcc catctaattg tggtgtcact 720 cttctatggc actgctatct ccatgtacct gcaaccacca tcccccaact ccaaggaccg 780 gggcaagatg gtgtccctct tctatgggat catcgcaccc atgctgaacc cccttatata 840 cacacttagg aataaagatg taaagggagc atttaagagg gtgattgtgt gggtcttctt 900 aatcaagaaa tag 913

<210> 2556 <211> 303 <212> PRT <213> Felis catus

<400> 2556 Gly Phe Ser Asp Arg Pro Trp Leu Glu Leu Pro Glu 1 Phe Ile Leu Leu 5 10 15 Leu Phe Val Val Phe Leu Val Ser Tyr Ile Leu Thr Ile Phe Gly Asn 20 25 30 Leu Ala Ile Ile Ala Val Ser His Leu Asp Pro Lys Leu His Thr Pro 35 40 45 Met Tyr Phe Phe Leu Thr Asn Leu Ser Leu Leu Asp Leu Cys Tyr Thr 50 55 60

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069269_0225_SL.TXT

Thr Ser 65 Thr Val Pro Gln 70 Met Leu Val Asn Ile Cys Ser Thr Arg Lys 75 80 Val Ile Ser Tyr Gly Gly Cys Val Ala Gln Leu Phe Ile Phe Leu Ala 85 90 95 Leu Gly Ser Thr Glu Cys Leu Leu Leu Ala Val Met Ser Leu Asp Arg 100 105 110 Phe Val Ala Ile Cys Arg Pro Leu His Tyr Ser Val Ile Met His Gln 115 120 125 Arg Leu Cys Leu Gln Leu Ala Ala Ala Ser Trp Ile Ser Gly Phe Gly 130 135 140 Asn Ser Val Leu Gln Ser Thr Leu Thr Leu Gln Leu Pro Leu Cys Gly 145 150 155 160 Arg Lys Glu Val Asp His Phe Phe Cys Glu Val Pro Ala Leu Leu Lys 165 170 175 Leu Ser Cys Val Asp Thr Thr Ala Asn Glu Ala Glu Leu Phe Phe Ile 180 185 190 Ser Val Leu Phe Leu Leu Leu Pro Leu Thr Leu Ile Leu Val Ser Tyr 195 200 205 Ala Phe Ile Ala Arg Ala Val Leu Arg Ile Gln Ser Ala Glu Gly Arg 210 215 220 Arg Lys Ala Phe Gly Thr Cys Gly Ser His Leu Ile Val Val Ser Leu 225 230 235 240 Phe Tyr Gly Thr Ala Ile Ser Met Tyr Leu Gln Pro Pro Ser Pro Asn 245 250 255 Ser Lys Asp Arg Gly Lys Met Val Ser Leu Phe Tyr Gly Ile Ile Ala 260 265 270

Page 2840

069269_0225_SL.TXT

Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys 275 280 285 Gly Ala Phe Lys Arg Val Ile Val Trp Val Phe Leu Ile Lys Lys

290 295 300 <210> 2557 <211> 935 <212> DNA <213> Felis catus <400> 2557 atggaaatgg ttgctctgga aaaccaaact atcactgaat ttgtcctcct tggtttccat 60 gatgtagctg agctgcatct cgttttcttt gttgtgctca ccattgtcta cgtgtccatt 120 gtcatgggga atgtgctgat cgtcgtggcg gtggttagct cacggagtct ccacacaccc 180 atgtatttct tcctggctaa cctgtccttc ctggagatcc tctacacctc cacagtggtg 240 cccaaaatgc tagagggctt cttgcaggaa gcggccatct ctgtggctgg ttgcttgctg 300 cagttcttta tcttcggttc tctagccacg gctgagtgct tcatgctggc tgtcatggcc 360 tatgatcgct acctggcaat ctgctatcca ctccgctacc cactcctgat gggacccagg 420 gggtgcttgg ggctggtggt catagcttgg ctctctggct tcatggtaga tggactggtt 480 gtggccctaa tgggccagct gaggttctgt ggccccaacc acattgacca cttttactgt 540 gacttcatgc ccttgatggg cctggcctgc tcggatccca gtgtggccca gatgacaaca 600 ttcattctgt ctgtggtctg cctcactgtc cccttcgggc tgattctgac atcttatgcc 660 cggatcgtgg taactgtgct caaagtccct gctggggccc agaggctaaa ggttttctcc 720 acctgctcct cccacctggt ggtggtgtcc accttctatg gaactctcat ggtcttgtac 780 attgcaccct ctgctgtcca ttcccaactt gtctccaagg tcttcgccct gctctacact 840 gtggtcaccc ctcttctcaa tcctgtgatc tacaccctga ggaacaagga ggttcatcat 900 gcattgcgga gacttctgta cattaagctc accaa 935 <210> 2558 <211> 312 <212> PRT <213> Felis catus

Page 2841

069269_0225_SL.TXT <220>

<221> MOD_RES <222> (312)..(312) <223> Any amino acid

<400> 2558 Met 1 Glu Met Val Ala 5 Leu Glu Asn Gln Thr Ile Thr Glu Phe Val Leu 10 15 Leu Gly Phe His Asp Val Ala Glu Leu His Leu Val Phe Phe Val Val 20 25 30 Leu Thr Ile Val Tyr Val Ser Ile Val Met Gly Asn Val Leu Ile Val 35 40 45 Val Ala Val Val Ser Ser Arg Ser Leu His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ala Asn Leu Ser Phe Leu Glu Ile Leu Tyr Thr Ser Thr Val Val 65 70 75 80 Pro Lys Met Leu Glu Gly Phe Leu Gln Glu Ala Ala Ile Ser Val Ala 85 90 95 Gly Cys Leu Leu Gln Phe Phe Ile Phe Gly Ser Leu Ala Thr Ala Glu 100 105 110 Cys Phe Met Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys 115 120 125 Tyr Pro Leu Arg Tyr Pro Leu Leu Met Gly Pro Arg Gly Cys Leu Gly 130 135 140 Leu Val Val Ile Ala Trp Leu Ser Gly Phe Met Val Asp Gly Leu Val 145 150 155 160 Val Ala Leu Met Gly Gln Leu Arg Phe Cys Gly Pro Asn His Ile Asp 165 170 175

Page 2842

His Phe Tyr Cys 180 Asp Phe Met 069269_0225_SL.TXT Pro Leu Met Gly Leu Ala 185 Cys 190 Ser Asp Pro Ser Val Ala Gln Met Thr Thr Phe Ile Leu Ser Val Val Cys Leu 195 200 205 Thr Val Pro Phe Gly Leu Ile Leu Thr Ser Tyr Ala Arg Ile Val Val 210 215 220 Thr Val Leu Lys Val Pro Ala Gly Ala Gln Arg Leu Lys Val Phe Ser 225 230 235 240 Thr Cys Ser Ser His Leu Val Val Val Ser Thr Phe Tyr Gly Thr Leu 245 250 255 Met Val Leu Tyr Ile Ala Pro Ser Ala Val His Ser Gln Leu Val Ser 260 265 270 Lys Val Phe Ala Leu Leu Tyr Thr Val Val Thr Pro Leu Leu Asn Pro 275 280 285 Val Ile Tyr Thr Leu Arg Asn Lys Glu Val His His Ala Leu Arg Arg 290 295 300 Leu Leu Tyr Ile Lys Leu Thr Xaa 305 310

<210> 2559 <211> 966 <212> DNA <213> Felis catus <400> 2559 ttagaattta aaaatggctt ttaaatacat ctttctcggg gaaacttctc cttttgacag caccttcctc agagcggcct tcatggcttc attgcgtaaa ctgtagataa ccggattgag tgtgggtggt atcaccgtgt agaatatgga aaacatgagg tccatagctg attgggagtc agaagggggc cgcagaaact caaaacctgc tgtggagagg aagaaggtga ctacaaacag gtgtggtagg caggtggcga agaccttggt ccggccctct gctgatggga tcctcagcac

120

180

240

300

Page 2843

069269_0225_SL.TXT ggcagagaag atgtggacgt aggagagcac aatggacacc aggcagatga atgctgctga agttgtgaag gcagccactg caatctcatt gatgaattca tgagaacaag ctagtttcag catctgagga atgtcacaga agaactggta aatgactctc tccccacaga gaggtatgga gaagttcaca gcagtatgca tgagcccaga gaagccccca gcaagccaca cagctgccac ggcgtgccta caagtgcagg ggtccataat ggtctcatac tgcaggggcc gacagatggc gacataccgg tcgtaagaca tcacggtgag gatggccact tctgatgagg ccagagctat gaagaagaaa acctgaagga tgcactgacc aagtgaaatg taaccgctgt tcgtaagtga atttgcaatg gactgaggca ctgtgacaga gatgaaacag aggtccagga cagagaggtg cttcaaaaag taatacatgg gggactgaag gcgatggtcc aacgtggtca cggtgatgat gaggaggttt cctgtcaagg ccatcaggta tgtcaccaaa aacagcaatg catataaaat ctgaagcttt cggttttcag aaaaccccat aaggaggaat ccactcatgg aggtcaaatt ggccat <210> 2560 <211> 321 <212> PRT <213> Felis catus <400> 2560

360

420

480

540

600

660

720

780

840

900

960

966

Met Ala Asn Leu Thr Ser Met Ser Gly Phe Leu Leu Met Gly Phe Ser 1 5 10 15 Glu Asn Arg Lys Leu Gln Ile Leu Tyr Ala Leu Leu Phe Leu Val Thr 20 25 30 Tyr Leu Met Ala Leu Thr Gly Asn Leu Leu Ile Ile Thr Val Thr Thr 35 40 45 Leu Asp His Arg Leu Gln Ser Pro Met Tyr Tyr Phe Leu Lys His Leu 50 55 60 Ser Val Leu Asp Leu Cys Phe Ile Ser Val Thr Val Pro Gln Ser Ile 65 70 75 80 Ala Asn Ser Leu Thr Asn Ser Gly Tyr Ile Ser Leu Gly Gln Cys Ile

Page 2844

069269_0225_SL.TXT

85 90 95 Leu Gln Val Phe Phe Phe Ile Ala Leu Ala Ser Ser Glu Val Ala Ile 100 105 110 Leu Thr Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125 Gln Tyr Glu Thr Ile Met Asp Pro Cys Thr Cys Arg His Ala Val Ala 130 135 140 Ala Val Trp Leu Ala Gly Gly Phe Ser Gly Leu Met His Thr Ala Val 145 150 155 160 Asn Phe Ser Ile Pro Leu Cys Gly Glu Arg Val Ile Tyr Gln Phe Phe 165 170 175 Cys Asp Ile Pro Gln Met Leu Lys Leu Ala Cys Ser His Glu Phe Ile 180 185 190 Asn Glu Ile Ala Val Ala Ala Phe Thr Thr Ser Ala Ala Phe Ile Cys 195 200 205 Leu Val Ser Ile Val Leu Ser Tyr Val His Ile Phe Ser Ala Val Leu 210 215 220 Arg Ile Pro Ser Ala Glu Gly Arg Thr Lys Val Phe Ala Thr Cys Leu 225 230 235 240 Pro His Leu Phe Val Val Thr Phe Phe Leu Ser Thr Ala Gly Phe Glu 245 250 255 Phe Leu Arg Pro Pro Ser Asp Ser Gln Ser Ala Met Asp Leu Met Phe 260 265 270 Ser Ile Phe Tyr Thr Val Ile Pro Pro Thr Leu Asn Pro Val Ile Tyr 275 280 285 Ser Leu Arg Asn Glu Ala Met Lys Ala Ala Leu Arg Lys Val Leu Ser

Page 2845

069269_0225_SL.TXT

290 295 300

Lys Gly Glu Val Ser Pro Arg Lys Met Tyr Leu Lys Ala Ile Phe Lys 305 310 315 320

Phe <210> 2561 <211> 952 <212> DNA <213> Felis catus <400> 2561 ctacccgcga gttaaagctt ttttccagag ggttctccag agagccgcct tgacctcctt 60 gttccgcaaa ctgtagatga tggggttgag catggaggtt accactgtgt agaagagagc 120 taggagctta tctgttcctg gcgaatggct ggccttgggc ctcaggtagg tgacagaccc 180 tgagccgtag aagagcgtca ctacaagcag gtgggaagag caggtggaca gagctttccg 240 gcggccttca ggtgagggca tgatcagcac agcagctagg attctgccat aggaagcgat 300 gatcagtaga aatgggctgg aaatgcaaag aacggctaca acaaagaccg cggcctcgtt 360 acgggatgta tccccgcagg caagagccag gatagggggg aggtcgcaga agaagtggtc 420 tatttcacag gggccacaga agttcaagga gaaaatatag ttggtctggc ccaagcctac 480 cacgcaaccc actgcccagg aaaccacggc cagctgggca cagagcccac ggctcattcg 540 tgtcgcgtag tgtagtgggg agcatatggc catgtagcgg tcaaaagcca tggccgccag 600 aagacagcac tcactgatgg caaacagcgt gaagaagaac atctgtgtgg cacacccctc 660 gcgggagatg ccccgggcct cactcacaag gctctgaagc atcttgggta tgaccgaaca 720 cgtgtagcca atctccaaga gagacaggtt ggccaggaag aagtacatgg gtgtgtggag 780 ggtggggttg gtgcagatgg ccagggctat gagagcgttg cccgtcaggg aggcgaggaa 840 catgagcagg atgagggtga atagaagcaa gcactgctcg gccgcggcag agaacttggc 900 gaatgcaaag tgcttgacag actcgctgtt gtcctgccac tgggaacagc tg 952 <210> 2562 <211> 316

Page 2846

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 2562 Phe 15 Ala Ser 1 Cys Ser Gln Trp Gln Asp Asn 5 Ser Glu 10 Ser Val Lys His Phe Ala Lys Phe Ser Ala Ala Ala Glu Gln Cys Leu Leu Leu Phe Thr 20 25 30 Leu Ile Leu Leu Met Phe Leu Ala Ser Leu Thr Gly Asn Ala Leu Ile 35 40 45 Ala Leu Ala Ile Cys Thr Asn Pro Thr Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Ala Asn Leu Ser Leu Leu Glu Ile Gly Tyr Thr Cys Ser Val 65 70 75 80 Ile Pro Lys Met Leu Gln Ser Leu Val Ser Glu Ala Arg Gly Ile Ser 85 90 95 Arg Glu Gly Cys Ala Thr Gln Met Phe Phe Phe Thr Leu Phe Ala Ile 100 105 110 Ser Glu Cys Cys Leu Leu Ala Ala Met Ala Phe Asp Arg Tyr Met Ala 115 120 125 Ile Cys Ser Pro Leu His Tyr Ala Thr Arg Met Ser Arg Gly Leu Cys 130 135 140 Ala Gln Leu Ala Val Val Ser Trp Ala Val Gly Cys Val Val Gly Leu 145 150 155 160 Gly Gln Thr Asn Tyr Ile Phe Ser Leu Asn Phe Cys Gly Pro Cys Glu 165 170 175 Ile Asp His Phe Phe Cys Asp Leu Pro Pro Ile Leu Ala Leu Ala Cys 180 185 190

Page 2847

Gly Asp Thr 195 Ser Arg Asn Glu 069269_0225_SL.TXT Ala Ala Val Phe Val Val 200 205 Ala Val Leu Cys Ile Ser Ser Pro Phe Leu Leu Ile Ile Ala Ser Tyr Gly Arg Ile 210 215 220 Leu Ala Ala Val Leu Ile Met Pro Ser Pro Glu Gly Arg Arg Lys Ala 225 230 235 240 Leu Ser Thr Cys Ser Ser His Leu Leu Val Val Thr Leu Phe Tyr Gly 245 250 255 Ser Gly Ser Val Thr Tyr Leu Arg Pro Lys Ala Ser His Ser Pro Gly 260 265 270 Thr Asp Lys Leu Leu Ala Leu Phe Tyr Thr Val Val Thr Ser Met Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Leu 290 295 300 Trp Arg Thr Leu Trp Lys Lys Ala Leu Thr Arg Gly 305 310 315

<210> 2563 <211> 945 <212> DNA <213> Felis catus <400> 2563

atgaacaaaa acaatggaag ttccatgaca gacttcatcc tgctggggtt ttctgatcgg 60 ccccagttag aacacatcat ctctggggtt gtcttcatct tctatattgt gactctggta 120 ggaaacacaa ccatcatcct tgtatctaac ctagacagcc agctccatac tcctatgtat 180 ttcttcctat ccaatttgtc ttttctggat ctctgttatg caactagcat tatcccacag 240 atgctggtaa atctatgggg tccaacaaag tctattacct acggagggtg tgtgctccaa 300 ttcttctttg cccttgactt gggagccaca gaatgtcttc tcttggctgt gatggcctat 360 gatcgctacg ccgctgtctg tcaacctctt cactacacag taataatgca ccctcaactt 420

Page 2848

069269_0225_SL.TXT

tgccaaaaga tggtgcttgt cgcctggtta ggtggtcttg gcagtgcctt aattctttgc 480 tccttgactc tgaaactgcc aagatgtggg caccgggagg tggacaattt tttctgtgag 540 atgccagcat tgctcaagat ggcttgtgtc tactcaaaag taattgaggt cattgtctat 600 gctcttggag tgatatttct tctagtacct ctattactaa ttctcatctc atatgcagtt 660 atcactcaag ctgtcatgag gatcaagtca acagcaaggt ggagtagggt ccttaatacc 720 tgtggttccc acctcacagt agtaactctg ttttatggaa cactcattta tatgtacatg 780 aagccacaga atagcacatc ccaagatgag gggaagttct ttacactctt ttacacaatc 840 gtcacaccca cccttaaccc tctgatctac actttaagaa acaaggatgt gaagagtgca 900 gtaaagagaa tactgtgtgc agaaaaatgg tcagcaaagt catga 945

<210> 2564 <211> 314 <212> PRT <213> Felis catus <400> 2564

Met Asn Lys Asn Asn Gly Ser Ser Met Thr Asp Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Asp Arg Pro Gln Leu Glu His Ile Ile Ser Gly Val Val Phe 20 25 30 Ile Phe Tyr Ile Val Thr Leu Val Gly Asn Thr Thr Ile Ile Leu Val 35 40 45 Ser Asn Leu Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Ala Thr Ser Ile Ile Pro Gln 65 70 75 80 Met Leu Val Asn Leu Trp Gly Pro Thr Lys Ser Ile Thr Tyr Gly Gly 85 90 95 Cys Val Leu Gln Phe Phe Phe Ala Leu Asp Leu Gly Ala Thr Glu Cys 100 105 110

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069269_0225_SL.TXT

Leu Leu Leu 115 Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Gln 120 125 Pro Leu His Tyr Thr Val Ile Met His Pro Gln Leu Cys Gln Lys Met 130 135 140 Val Leu Val Ala Trp Leu Gly Gly Leu Gly Ser Ala Leu Ile Leu Cys 145 150 155 160 Ser Leu Thr Leu Lys Leu Pro Arg Cys Gly His Arg Glu Val Asp Asn 165 170 175 Phe Phe Cys Glu Met Pro Ala Leu Leu Lys Met Ala Cys Val Tyr Ser 180 185 190 Lys Val Ile Glu Val Ile Val Tyr Ala Leu Gly Val Ile Phe Leu Leu 195 200 205 Val Pro Leu Leu Leu Ile Leu Ile Ser Tyr Ala Val Ile Thr Gln Ala 210 215 220 Val Met Arg Ile Lys Ser Thr Ala Arg Trp Ser Arg Val Leu Asn Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Leu Ile 245 250 255 Tyr Met Tyr Met Lys Pro Gln Asn Ser Thr Ser Gln Asp Glu Gly Lys 260 265 270 Phe Phe Thr Leu Phe Tyr Thr Ile Val Thr Pro Thr Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Ser Ala Val Lys Arg Ile 290 295 300 Leu Cys Ala Glu Lys Trp Ser Ala Lys Ser 305 310

Page 2850

069269_0225_SL.TXT <210> 2565 <211> 941 <212> DNA <213> Felis catus <400> 2565

atggggggag gaaataattc ggtggtgtct gagattgtgt tggtgggact caccaattct 60 ttgaagatgc agcttgtctt atttctagtt ttctctgtgt tctatgtcac aggtatttta 120 ggaaacctcc tcattgtgct cacagtgatc tctgactccc atttacactc ccctatgtac 180 ttcctgctgg ccaacctctc ttttattgac atgtgggttt cctccattgc agctcccaag 240 atgatttctg atcttttcaa ggagagaaaa gtaatctctt tccaaggctg cattgctcag 300 atgttcttca ttcatgttat tggaggaact gagatggttc tgctcattgc catggccctt 360 gaccgttatg ttgctatatg caggcctctt cactacctga ccatcatgaa cttcagaact 420 tgtattttac tcttggtggt ggcctggacc attgggatca tccactcact gatccaactg 480 gtgtttgttg taaacctgcc actctgtggc cccaacgaac tggacagctt ttactgtgat 540 cttcctcgat ttattaggct tgcctgcaca gacacttaca gattggagct catggtcact 600 gccaatagtg gtttcatctc tctggggact tttttcattt tggttatttc ctatatcttc 660 accttggtca ttgtttggca acgttcttca ggtggcttgt ccaaggccct ctctactctg 720 tcagctcaca tcacagtggt agtcttgttt tttggtccat gtatttttgt gtactcatgg 780 ccatttccca cagtgccagt ggataagttc cttgccattt ttgatgtaat tatcactcca 840 tttctgaacc ctgccatcta tacttttagg aataaagagg tgaaagtggc aatgaggaga 900 atattcagtc aggtgtcgag tttcaggaag atgttataag t 941

<210> 2566 <211> 312 <212> PRT <213> Felis catus <400> 2566

Met Gly Gly Gly Asn Asn Ser Val Val Ser Glu Ile Val Leu Val Gly 1 5 10 15 Leu Thr Asn Ser Leu Lys Met Gln Leu Val Leu Phe Leu Val Phe Ser 20 25 30

Page 2851

069269_0225_SL.TXT

Val Phe Tyr 35 Val Thr Gly Ile Leu Gly Asn Leu Leu Ile Val Leu Thr 40 45 Val Ile Ser Asp Ser His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Phe Ile Asp Met Trp Val Ser Ser Ile Ala Ala Pro Lys 65 70 75 80 Met Ile Ser Asp Leu Phe Lys Glu Arg Lys Val Ile Ser Phe Gln Gly 85 90 95 Cys Ile Ala Gln Met Phe Phe Ile His Val Ile Gly Gly Thr Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Leu Thr Ile Met Asn Phe Arg Thr Cys Ile Leu Leu 130 135 140 Leu Val Val Ala Trp Thr Ile Gly Ile Ile His Ser Leu Ile Gln Leu 145 150 155 160 Val Phe Val Val Asn Leu Pro Leu Cys Gly Pro Asn Glu Leu Asp Ser 165 170 175 Phe Tyr Cys Asp Leu Pro Arg Phe Ile Arg Leu Ala Cys Thr Asp Thr 180 185 190 Tyr Arg Leu Glu Leu Met Val Thr Ala Asn Ser Gly Phe Ile Ser Leu 195 200 205 Gly Thr Phe Phe Ile Leu Val Ile Ser Tyr Ile Phe Thr Leu Val Ile 210 215 220 Val Trp Gln Arg Ser Ser Gly Gly Leu Ser Lys Ala Leu Ser Thr Leu 225 230 235 240

Page 2852

069269_0225_SL.TXT

Ser Ala His Ile Thr Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Val Tyr Ser Trp Pro Phe Pro Thr Val Pro Val Asp Lys Phe Leu Ala 260 265 270 Ile Phe Asp Val Ile Ile Thr Pro Phe Leu Asn Pro Ala Ile Tyr Thr 275 280 285 Phe Arg Asn Lys Glu Val Lys Val Ala Met Arg Arg Ile Phe Ser Gln 290 295 300 Val Ser Ser Phe Arg Lys Met Leu 305 310

<210> 2567 <211> 971 <212> DNA <213> Felis catus <400> 2567

atggatggag gaaatcactc agtggtgtct gaatttttgt tgctgggact caccagttct 60 tgggagattc agattcttct tttttgtttt ttactatatt ttatatagca agtatgttag 120 gaaaccttct cattgtgctc acaatcattt cagaccatca cttacattcc cccatgtact 180 ttttgctggc aaatctttcc atcattgaca ctggtgtttc cagcattgca agcccaaaga 240 tgatttacga ccttttcaga aaacataaag tcatctcgtt ggcagggtgc attactcaga 300 tgttctttat tcacactgtt gggggtacgg agatggtgct gctcatagtt atggcctatg 360 acagatacat tgctatctgt aagcctctcc actacctgac catcatgagc ataagaatgt 420 gcatttccct tttggctgtt gcctggacca ttggactcat ccactccgtg gcccaactgg 480 cttttgttat aaacttgccc ttttgtggtc ccaacaaaat ggatagtttt tattgtgatt 540 ttcctcggtt catcaaactt gcatgtacag acacatatag actggagttt ctggtcactg 600 ccaacagtgg tttcatctcc atgggcacct tcttcatctt gattgtgtct tacatcttca 660 tcctggtcac agttcgcaaa cactcttcag gtggttcatc caaggctctc tccactctct 720

Page 2853

069269_0225_SL.TXT ctgctcacat caccgtggtg gtctttttct ttggtccttg cattattgtc tatgtgtggc cattccctac cttaccaatc gataaatttt tagccatctt tgatgccctt atcactcctt ttatgaatcc tattatctat acattcagaa acaaggagat gaaagtggca ataaagagac tgtttggtaa ggttttaagt gtcaggaaga gttctttcat gaacaatcaa agccatttgg attcatcttg a

780

840

900

960

971 <210> 2568 <211> 285 <212> PRT <213> Felis catus <400> 2568

Met 1 Leu Gly Asn Leu Leu Ile Val Leu Thr Ile Ile Ser Asp His His 5 10 15 Leu His Ser Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Ile Ile Asp 20 25 30 Thr Gly Val Ser Ser Ile Ala Ser Pro Lys Met Ile Tyr Asp Leu Phe 35 40 45 Arg Lys His Lys Val Ile Ser Leu Ala Gly Cys Ile Thr Gln Met Phe 50 55 60 Phe Ile His Thr Val Gly Gly Thr Glu Met Val Leu Leu Ile Val Met 65 70 75 80 Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Lys Pro Leu His Tyr Leu Thr 85 90 95 Ile Met Ser Ile Arg Met Cys Ile Ser Leu Leu Ala Val Ala Trp Thr 100 105 110 Ile Gly Leu Ile His Ser Val Ala Gln Leu Ala Phe Val Ile Asn Leu 115 120 125 Pro Phe Cys Gly Pro Asn Lys Met Asp Ser Phe Tyr Cys Asp Phe Pro 130 135 140

Page 2854

069269_0225_SL.TXT

Arg Phe Ile Lys Leu Ala Cys Thr Asp Thr Tyr Arg Leu Glu Phe Leu 145 150 155 160 Val Thr Ala Asn Ser Gly Phe Ile Ser Met Gly Thr Phe Phe Ile Leu 165 170 175 Ile Val Ser Tyr Ile Phe Ile Leu Val Thr Val Arg Lys His Ser Ser 180 185 190 Gly Gly Ser Ser Lys Ala Leu Ser Thr Leu Ser Ala His Ile Thr Val 195 200 205 Val Val Phe Phe Phe Gly Pro Cys Ile Ile Val Tyr Val Trp Pro Phe 210 215 220 Pro Thr Leu Pro Ile Asp Lys Phe Leu Ala Ile Phe Asp Ala Leu Ile 225 230 235 240 Thr Pro Phe Met Asn Pro Ile Ile Tyr Thr Phe Arg Asn Lys Glu Met 245 250 255 Lys Val Ala Ile Lys Arg Leu Phe Gly Lys Val Leu Ser Val Arg Lys 260 265 270 Ser Ser Phe Met Asn Asn Gln Ser His Leu Asp Ser Ser 275 280 285

<210> 2569 <211> 932 <212> DNA <213> Felis catus <400> 2569 atggatggag ccaaccaatc tgtggtatat gagtttgtgt tcctgggact ctctaattca tgggagatcc agcttcttct tttcttcttt tcctctgtgt tctacatggc aagcctaatg ggaaatctcc tcattgtgtt ctctgtgagt actgacccta acttgcactc tcccatgtac ttcctgctgg ccaatctctc ctttcttgat gtgggggttt gctctattgc agcccccaaa atgatttatg acctcttcag aaaacgcaaa gccatctctt ttgggggttg tatatctcag

120

180

240

300

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atcttcttta ttcatgctat tggggggaca gaaatggtgc tgctcattgc catggccttt 360 gacagatatg ttgctatatg taagcctctc cactacctga ccattatgag cccacgaatg 420 tgcattttga ttttggctgc agcctgggtc cttggcctca tccactcagt ggcccaattg 480 gcttttgttg tagacttacc tttctgtggt cctaatgtat tggacagctt ttattgtgac 540 cttcctcagc tcattaaact tgcctgcaca gagaccaata ggctggagtt catggtcaca 600 gccaatagtg gactcatctc tgtgggttct ttctttatac tgattatttc ttacatcatc 660 attctggtca cagtttggaa acactcttca ggtgggttat ccaaggccct ctctactttg 720 tcagctcatg tcactgtggt ggttttattc tttgggccat taatcttctt ctacacctgg 780 cccttcccct catcacactt ggacaaattt cttgccatct ttgatgcagt tctcacacct 840 tttctgaatc cagtcatcta cacattcagg aacaaggaga tgaaggcagc aatgaagaaa 900 ctctgtcatc agcttgtgag ttacaggagg at 932

<210> 2570 <211> 311 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (311)..(311) <223> Any amino acid <400> 2570

Met Asp Gly Ala Asn Gln Ser Val Val Tyr Glu Phe Val Phe Leu Gly 1 5 10 15 Leu Ser Asn Ser Trp Glu Ile Gln Leu Leu Leu Phe Phe Phe Ser Ser 20 25 30 Val Phe Tyr Met Ala Ser Leu Met Gly Asn Leu Leu Ile Val Phe Ser 35 40 45 Val Ser Thr Asp Pro Asn Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60

Page 2856

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Asn 65 Leu Ser Phe Leu Asp Val Gly Val Cys Ser Ile Ala Ala Pro Lys 70 75 80 Met Ile Tyr Asp Leu Phe Arg Lys Arg Lys Ala Ile Ser Phe Gly Gly 85 90 95 Cys Ile Ser Gln Ile Phe Phe Ile His Ala Ile Gly Gly Thr Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Ile Leu Ile 130 135 140 Leu Ala Ala Ala Trp Val Leu Gly Leu Ile His Ser Val Ala Gln Leu 145 150 155 160 Ala Phe Val Val Asp Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Ser 165 170 175 Phe Tyr Cys Asp Leu Pro Gln Leu Ile Lys Leu Ala Cys Thr Glu Thr 180 185 190 Asn Arg Leu Glu Phe Met Val Thr Ala Asn Ser Gly Leu Ile Ser Val 195 200 205 Gly Ser Phe Phe Ile Leu Ile Ile Ser Tyr Ile Ile Ile Leu Val Thr 210 215 220 Val Trp Lys His Ser Ser Gly Gly Leu Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Val Thr Val Val Val Leu Phe Phe Gly Pro Leu Ile Phe 245 250 255 Phe Tyr Thr Trp Pro Phe Pro Ser Ser His Leu Asp Lys Phe Leu Ala 260 265 270

Page 2857

0 6926 ί9_02 25_S iL.TX T Ile Phe Asp Ala Val Leu Thr Pro Phe Leu Asn Pro Val Ile Tyr Thr 275 280 285 Phe Arg Asn Lys Glu Met Lys Ala Ala Met Lys Lys Leu Cys His Gln 290 295 300 Leu Val Ser Tyr Arg Arg Xaa 305 310

<210> 2571 <211> 935 <212> DNA <213> Felis catus <400> 2571

atggatggag cgaatcactc tgtggtgtca gagtttgtgt tcctgggact caccgattcc 60 tgggagatcc aacttctcct ctttgtgttc tcctccacgt tttatgtggc aagcatgatg 120 ggaaactccc tcattatgct cactgtgacc tctgaccctc acttacactc ccccatgtac 180 tttctgttgg ccaacctctc cttcattgac ctgggagttt cttctgtcac ttctcccaag 240 atgatttatg atctttttag aaagcgtaaa gtcatctcct ttggaggctg catcgctcaa 300 atcttcttta tccacgtcat tggtggtgtg gagatggtgc tgctcatcgc catggccttt 360 gacagatatg ttgccatatg taagcctctc cactatctga ccatcatgag cccaagaatg 420 tgcctcttct ttttagtggc tgcctggatg actggcctca tccactccat ggttcaactg 480 gcgtttgtgg taaacttacc cttctgtggt cctaatgtgt tggacagctt ttactgtgac 540 cttcctcggt tcatcaaact tgcctgcacg gacaccgacc gactagagtt tatggtcaca 600 gccaacagtg gattcatctc tgttggctcc ttcctcatac tgatcatttc ctatatcatc 660 atcattctca ctgttcagaa acactcttca gctggttcat ccaaggctct gtccacactg 720 tcagctcaca tcactgtggt attcttgttc tttggtcctt tgattttttt ttatacatgg 780 ccatctccct ccatacacct ggataagttt ctggccatct ttgatgctat tctcactcct 840 ttcctaaatc cagtcatcta tacattcagg aaccaagaaa tgcaggtggc aatgaggaga 900 gtatgcagac agctagtgaa ttacaggaag atctc 935

<210> 2572

Page 2858

069269_0225_SL.TXT <211> 312 <212> PRT <213> Felis catus

<400> 2572 Leu 15 Gly Met 1 Asp Gly Ala Asn His Ser Val 5 Val Ser 10 Glu Phe Val Phe Leu Thr Asp Ser Trp Glu Ile Gln Leu Leu Leu Phe Val Phe Ser Ser 20 25 30 Thr Phe Tyr Val Ala Ser Met Met Gly Asn Ser Leu Ile Met Leu Thr 35 40 45 Val Thr Ser Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Phe Ile Asp Leu Gly Val Ser Ser Val Thr Ser Pro Lys 65 70 75 80 Met Ile Tyr Asp Leu Phe Arg Lys Arg Lys Val Ile Ser Phe Gly Gly 85 90 95 Cys Ile Ala Gln Ile Phe Phe Ile His Val Ile Gly Gly Val Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Leu Phe Phe 130 135 140 Leu Val Ala Ala Trp Met Thr Gly Leu Ile His Ser Met Val Gln Leu 145 150 155 160 Ala Phe Val Val Asn Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Ser 165 170 175 Phe Tyr Cys Asp Leu Pro Arg Phe Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190

Page 2859

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Asp Arg Leu 195 Glu Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Val 200 205 Gly Ser Phe Leu Ile Leu Ile Ile Ser Tyr Ile Ile Ile Ile Leu Thr 210 215 220 Val Gln Lys His Ser Ser Ala Gly Ser Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Phe Leu Phe Phe Gly Pro Leu Ile Phe 245 250 255 Phe Tyr Thr Trp Pro Ser Pro Ser Ile His Leu Asp Lys Phe Leu Ala 260 265 270 Ile Phe Asp Ala Ile Leu Thr Pro Phe Leu Asn Pro Val Ile Tyr Thr 275 280 285 Phe Arg Asn Gln Glu Met Gln Val Ala Met Arg Arg Val Cys Arg Gln 290 295 300 Leu Val Asn Tyr Arg Lys Ile Ser 305 310

<210> 2573 <211> 939 <212> DNA <213> Felis catus <400> 2573

atggatagag caaatcactc tgtggtgtca gagtttgtgt tcctgggact caccgattcc 60 tgggagatcc aacttctcct ctttgtgttc tcctctatgg tttatgtggc aagcatgatg 120 ggaaactccc tcatcatgct cactgtgatt tctgaccctc acttacactc ccccatgtac 180 tttctgttgg ccaacctctc cttcattgac ctgggagttt cttgtgtcat ttctccgaag 240 atgatttatg accttttcag aaagcgtaag gtcatctcct ttggtggctg catcgctcaa 300 atcttcttca tccacgtcat tggtggcgtg gagatggtgc tgctcatcgc catggccttt 360 gacagatatg ttgccatatg caagcctctg cactacttga ctattatgaa ccgaaaaatg 420

Page 2860

069269_0225_SL.TXT

tgtattttgc ttacagttgc tgcctgggta attggcttga cccactctgt gattcaactg 480 gtttttgtaa taacattgcc attctgtggc cctaatgtgt tagacagctt ttattgtgac 540 tttcctcggt tcatcagact tgcctgcaca gacacctacc gtctagagtt catggtcata 600 gccaacagtg ggttcatatc tctgggatca ttcttcatat tgattgtctc ctacatttct 660 atcctgatca ctgttcggaa acactcttca gcaggcacat ctaaggccct ctccactttg 720 tcaactcatg tcatggtggt gattttgttc tttggccctt gcatcttcgt ttatatctgg 780 cctcacccca cctcacacct agacaaaaat cttgttgtct ttgatgcagt tctcactcct 840 ttttttaact cagtcatcta tacattcagg aacaaagaga tgaaagtggc aatgaggaaa 900 gtgtgtagtc ggtttattat ttatagaagg atttcttaa 939

<210> 2574 <211> 312 <212> PRT <213> Felis catus

<400> 2574 His Ser Val Val Ser Glu Phe Val Phe Leu Gly Met Asp 1 Arg Ala Asn 5 10 15 Leu Thr Asp Ser Trp Glu Ile Gln Leu Leu Leu Phe Val Phe Ser Ser 20 25 30 Met Val Tyr Val Ala Ser Met Met Gly Asn Ser Leu Ile Met Leu Thr 35 40 45 Val Ile Ser Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Phe Ile Asp Leu Gly Val Ser Cys Val Ile Ser Pro Lys 65 70 75 80 Met Ile Tyr Asp Leu Phe Arg Lys Arg Lys Val Ile Ser Phe Gly Gly 85 90 95 Cys Ile Ala Gln Ile Phe Phe Ile His Val Ile Gly Gly Val Glu Met 100 105 110

Page 2861

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Val Leu Leu 115 Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 120 125 Pro Leu His Tyr Leu Thr Ile Met Asn Arg Lys Met Cys Ile Leu Leu 130 135 140 Thr Val Ala Ala Trp Val Ile Gly Leu Thr His Ser Val Ile Gln Leu 145 150 155 160 Val Phe Val Ile Thr Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Ser 165 170 175 Phe Tyr Cys Asp Phe Pro Arg Phe Ile Arg Leu Ala Cys Thr Asp Thr 180 185 190 Tyr Arg Leu Glu Phe Met Val Ile Ala Asn Ser Gly Phe Ile Ser Leu 195 200 205 Gly Ser Phe Phe Ile Leu Ile Val Ser Tyr Ile Ser Ile Leu Ile Thr 210 215 220 Val Arg Lys His Ser Ser Ala Gly Thr Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Thr His Val Met Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Val Tyr Ile Trp Pro His Pro Thr Ser His Leu Asp Lys Asn Leu Val 260 265 270 Val Phe Asp Ala Val Leu Thr Pro Phe Phe Asn Ser Val Ile Tyr Thr 275 280 285 Phe Arg Asn Lys Glu Met Lys Val Ala Met Arg Lys Val Cys Ser Arg 290 295 300 Phe Ile Ile Tyr Arg Arg Ile Ser

305 310

Page 2862

069269_0225_SL.TXT <210> 2575 <211> 938 <212> DNA <213> Felis catus <400> 2575 tggatggagg gaatcactcg gttgtgtctg agtttgtgtt tctgggactc actcattcat 60 gggagatcca gcttctcctc ctggtgttct cctctgtgct ctatgtggca agcatgaccg 120 ggaacatcct cattgtgttc tctgtgaccg ttgatcctca cttgcattcc cccatgtact 180 tcctactggc caatctctct ttcattgact tgggagcctg ctctgccacc tcacccaaga 240 tgatttatga ccttttcaga aagcacaaag tcatctcctt tggaggctgc atcgcccaga 300 tcttcttcat ccacgtcatt ggtggtgtgg agatggtgct gctcatcgcc atggcctttg 360 acagatatgt tgccatctgc aagcctctcc actacttgac catcatgagc ccacgaatgt 420 gcattttgtt tctggctgct gcctgggccc ttggtgtcag tcactcactg ttccaactag 480 cattcattgt taatttaccc ttctgtggtc ctaatgtatt ggacagcttt tactgtgacc 540 ttcctcggct cctcagactg gcctgtacag atacttacag attgcagttc atggtcactg 600 ttaacagtgg gtttatctgt gtgggttcct tcttgatact cctcatctcc tacgtcttca 660 tcctgttttc tgtttggaaa cattcctccg gtggctcatc caaggccgtt tccaccctgt 720 cagctcacat cactgtggtc cttttgtttt tcggcccaac catgtttgtc tatacatggc 780 cacatcccaa ttcccaaatg gacaaatttc ttgccctgtc tgatgcagtt atcactcctt 840 ttctgaatcc agtcatctac acgctcagga ataatgagat gaaggcagca gtgaagagaa 900 ctttgagacc attaatgatt tttaggaaga tttcataa 938 <210> 2576 <211> 311 <212> PRT <213> Felis catus <400> 2576

Asp Gly Gly Asn His Ser Val Val Ser Glu Phe Val Phe Leu Gly Leu

1 5 10 15

Thr His Ser Trp Glu Ile Gln Leu Leu Leu Leu Val Phe Ser Ser Val

Page 2863

069269_0225_SL.TXT 25 30

Leu Tyr Val 35 Ala Ser Met Thr Gly Asn Ile Leu Ile Val Phe Ser Val 40 45 Thr Val Asp Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ala Asn 50 55 60 Leu Ser Phe Ile Asp Leu Gly Ala Cys Ser Ala Thr Ser Pro Lys Met 65 70 75 80 Ile Tyr Asp Leu Phe Arg Lys His Lys Val Ile Ser Phe Gly Gly Cys 85 90 95 Ile Ala Gln Ile Phe Phe Ile His Val Ile Gly Gly Val Glu Met Val 100 105 110 Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro 115 120 125 Leu His Tyr Leu Thr Ile Met Ser Pro Arg Met Cys Ile Leu Phe Leu 130 135 140 Ala Ala Ala Trp Ala Leu Gly Val Ser His Ser Leu Phe Gln Leu Ala 145 150 155 160 Phe Ile Val Asn Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Ser Phe 165 170 175 Tyr Cys Asp Leu Pro Arg Leu Leu Arg Leu Ala Cys Thr Asp Thr Tyr 180 185 190 Arg Leu Gln Phe Met Val Thr Val Asn Ser Gly Phe Ile Cys Val Gly 195 200 205 Ser Phe Leu Ile Leu Leu Ile Ser Tyr Val Phe Ile Leu Phe Ser Val 210 215 220 Trp Lys His Ser Ser Gly Gly Ser Ser Lys Ala Val Ser Thr Leu Ser

Page 2864

0 6926 9_02 25_S L.TX T 225 230 235 240 Ala His Ile Thr Val Val Leu Leu Phe Phe Gly Pro Thr Met Phe Val 245 250 255 Tyr Thr Trp Pro His Pro Asn Ser Gln Met Asp Lys Phe Leu Ala Leu 260 265 270 Ser Asp Ala Val Ile Thr Pro Phe Leu Asn Pro Val Ile Tyr Thr Leu 275 280 285 Arg Asn Asn Glu Met Lys Ala Ala Val Lys Arg Thr Leu Arg Pro Leu 290 295 300 Met Ile Phe Arg Lys Ile Ser

305 310 <210> 2577 <211> 937 <212> DNA <213> Felis catus <400> 2577

ttattagata ccagtaggat ccataacccg cttgcccagt cttctcatgg ccactctcat 60 gtctttgttt cttaatgtat agatggcagg atcaagaggg gggtgatagc gaagttggca 120 atgaacaaat acttatccag tgatgatgta gggaaaggcc acacatagag aaacatgcat 180 ggcataaaaa caaaatcact acagtgatgt gagctgacaa tgtgacaaat gctttggaca 240 agtcccctga agaacgtttc cagacagtga ccaaaatgaa gatataggat ataattaagg 300 agaagaaagt agccatggat ataaacccac tgttggcagt gattacaaac tctagcttgt 360 aagtgtctac acaagcaagt ttcatgacgc gaggaaaatc acagtaaaaa ctatctactt 420 cattagggcc acaaaagggc aagtttatga caaaaacaaa ctgagataca gcatggatta 480 tccccactat ccaggcagcc actacaaagg agacacacgt tttggggctc atgatggtca 540 ggtagtggag aggtttacag attgcggtgt accggtcata tgccatggct atgagcagca 600 ccatctcgcc tccacccatg acgtgaataa aaaatatctg tatcatgcat tttggaaagg 660 aaatgatgtt gcagtcagtg aaaagatcag agatcgtttt gggcactgtg gtagaggaca 720

Page 2865

069269_0225_SL.TXT gacctagatc aagaagggag aggttggcca ataggaagta catgggggtg tgtaaatgag agtcaataat tactgtgaac acaatgaaga ggtttcccag gataattccc atgtagaaca cagagaagaa cccaaagaga aaaaggtgca tctcccatga atttgaaagg ccaatcaata caaattcaga taccacagtg tcatttggtc catccat

780

840

900

937 <210> 2578 <211> 281 <212> PRT <213> Felis catus <400> 2578

Met Asp Gly 1 Pro Asn Asp Thr Val 5 Val Ser Glu Phe Val Leu Ile Gly 10 15 Leu Ser Asn Ser Trp Glu Met His Leu Phe Leu Phe Gly Phe Phe Ser 20 25 30 Val Phe Tyr Met Gly Ile Ile Leu Gly Asn Leu Phe Ile Val Phe Thr 35 40 45 Val Ile Ile Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Leu Leu Asp Leu Gly Leu Ser Ser Thr Thr Val Pro Lys 65 70 75 80 Thr Ile Ser Asp Leu Phe Thr Asp Cys Asn Ile Ile Ser Phe Pro Lys 85 90 95 Cys Met Ile Gln Ile Phe Phe Ile His Val Met Gly Gly Gly Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Thr Ile Met Ser Pro Lys Thr Cys Val Ser Phe 130 135 140

Page 2866

Val 145 Val Ala Ala Trp Ile 150 Val 069269_0225_SL.TXT Gly Ile Ile His Ala Val 155 Ser Gln Phe 160 Val Phe Val Ile Asn Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Ser 165 170 175 Phe Tyr Cys Asp Phe Pro Arg Val Met Lys Leu Ala Cys Val Asp Thr 180 185 190 Tyr Lys Leu Glu Phe Val Ile Thr Ala Asn Ser Gly Phe Ile Ser Met 195 200 205 Ala Thr Phe Phe Ser Leu Ile Ile Ser Tyr Ile Phe Ile Leu Val Thr 210 215 220 Val Trp Lys Arg Ser Ser Gly Asp Leu Ser Lys Ala Phe Val Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Ile Leu Phe Leu Cys His Ala Cys Phe 245 250 255 Ser Met Cys Gly Leu Ser Leu His His His Trp Ile Ser Ile Cys Ser 260 265 270 Leu Pro Thr Ser Leu Ser Pro Pro Ser

275 280 <210> 2579 <211> 943 <212> DNA <213> Felis catus <400> 2579 tcaaccaatt ctggaatata ctatcttttg cacacttgtt ttattgatac ccttaggtct ttgttctgta atgtacagat ggcagaattc gtgacaaggg tgatagcaaa gtcaacaaca aacaggtatt tattaattga tgatgtgggg aaaggccata catagagaaa catgaatgga gtgaaaaaag aactacgaca atgatgtgag ttgacagagt gataaatgct ttggataagt ctcctgaaga atgtttccag acagtgacca aaataaagac ataggaaagg attattagca

120

180

240

300

Page 2867

069269_0225_SL.TXT

ggaagaaggt gcccatgctc atgaagccac tgttggcagc aataataaac tcaaacttgg 360 ctgcatctct gcatgcaagt tttatgatcc tgggaagtca cagtaaaagc tgtcttcttc 420 attaggacca caaaaaggca agtttataat caaagcaaac tgagacatag catgaatcaa 480 cccagttacc catccagtga ttacaaatga aacatatatt ttagggttca tcatgttcag 540 gtagtgaagt gggttataga ttgctgtgca cctgtcaaat gccatggcga tgagtaacac 600 catctccatt ccccctatga tgtggatgaa acgtatctgt gctatacaac cttggaaaga 660 aattacttgg cattcactta aaaggtcttt gattgtcttg gggactataa tagaagagag 720 gcccacatca atgagggaca agttggccag caggaagtac ataggagaat gtaagtgaga 780 atcaaaaatt atcaaaaaca aaataaaaag atttctcaac atgatcacta aatagagcaa 840 agaacataac aaggtaaaaa caaacaaaca ccccttttct cccaagagca agaaaggcca 900 gtaacacaat ctcagtgacc acagaatcat ttagaccacc cat 943

<210> 2580 <211> 54 <212> PRT <213> Felis catus <400> 2580

Ser Thr Asn Ser Gly Ile Tyr Tyr Leu Leu His Thr Cys Phe Ile Asp 1 5 10 15 Thr Leu Arg Ser Leu Phe Cys Asn Val Gln Met Ala Glu Phe Val Thr 20 25 30 Arg Val Ile Ala Lys Ser Thr Thr Asn Arg Tyr Leu Leu Ile Asp Asp 35 40 45 Val Gly Lys Gly His Thr

<210> 2581 <211> 746 <212> DNA <213> Felis catus <400> 2581 agaaacatga ataaggtaaa aaactgagtc aacacagtga tgtgagctga cagagtgaca 60

Page 2868

069269_0225_SL.TXT aatgccttgg gaaaggatta aattcaaact aaggttttta cataagtagt ttcatgatgt gctataacta aaactttgca gtaaagaaaa gtaaatggga taaatagatc tcccagcaac <210> 2582 <211> 176 <212> PRT <213> Felis catus gtaagtcttt gtaaaaagaa tggctccatc cttctaatat taaccacagt ccaggtactg acaccatctc aagaaatctt gtccacatca ataaaaaaaa aaggagaatg acaaactcag ctgagaacat ggtgcccatg tctgcatgca aaccacaaaa tacccagcaa aagaggttta cactctgccc gcattcatta atgagggact ataccagaaa tcaacatgag aaacca

ttccagacag tgaccaaaat aaggatatag 120 ctcatgatgt tattattggc agcaataata 180 agtttgatga ttctggaaaa gttataatag 240 gcacacgttt gtaacgaaaa caaatggaga 300 atagttacaa atgaaacatg tattttaggg 360 cagattgcca tgtatctgtc agacgctatg 420 attatgtgga tgaagcatgt ctgtgccctg 480 aaaaagtcta taatcatctt gggaactgtg 540 ggttggccag aaggaagtac acaggaaaat 600 gaaaatgaag aaatttcctg ggacgatccc 660 aaaaacttta gtctcccaag atgtagaaag 720

746

<400> 2582 Met Ile Ile Asp Phe Phe Asn Glu Cys 1 5 Arg Ala Gln Thr Cys Phe Ile His Ile 20 25 Leu Val Ile Ala Ile Ala Ser Asp Arg 35 40 Leu Gln Tyr Leu Asp Ile Met Asn Pro 50 55 Thr Ile Cys Trp Val Thr Val Val Asn 65 70

Lys 10 Ile Ser Leu Gln Ser 15 Phe Met Gly Arg Val Glu 30 Met Val Tyr Met Ala Ile 45 Cys Lys Pro Lys Ile His 60 Val Ser Phe Val Tyr Leu 75 Cys Leu His Leu Phe 80

Page 2869

Ser Leu Gln Thr Cys 85 Ala Phe 069269_0225_SL.TXT Val Val Ile Leu Glu Val 90 Lys Thr 95 Phe Tyr Tyr Asn Phe Ser Arg Ile Ile Lys Leu Ala Cys Arg Asp Gly Ala 100 105 110 Lys Phe Glu Phe Ile Ile Ala Ala Asn Asn Asn Ile Met Ser Met Gly 115 120 125 Thr Phe Phe Leu Leu Ile Leu Ser Tyr Ile Leu Ile Leu Val Thr Val 130 135 140 Trp Lys Cys Ser Gln Lys Asp Leu Pro Lys Ala Phe Val Thr Leu Ser 145 150 155 160 Ala His Ile Thr Val Leu Thr Gln Phe Phe Thr Leu Phe Met Phe Leu 165 170 175

<210> 2583 <211> 914 <212> DNA <213> Felis catus <400> 2583

ctagaattca cattccattt actcagtcgt ctcattgcag tcttcatgtc tttgttcctc 60 agtgtgtata taatcgggtt caagagagga gtgaccacag aataaaacac agcaagggat 120 ttatctaggg acttgatggg gaatggccag gcataaatga agatacatgg tccgaagaac 180 aaaagaacta ctgtgatgtg agcagtcaga gtggacagag ccttggacga cttgtctgaa 240 gggcgttgct ggatggttac caggatgata gcataggaga tgattaggaa aacaaaagaa 300 cacacagtga gcacaccact gttagcaatg accatgacat ccaatctata ggtgtctata 360 caagcaagtt tgataaccct aggtaggtcg cagtaaaagc tatcaacctc attgggacca 420 cagaaaggta agtttactgc aaaagccaac tggctcactg aatggagaaa gccagttccc 480 catgcagcag tcacaatgcc aaaacataca tggtcacaca taactgtaga gtagcgaaga 540 ggtttacaga ttgctacata tctgtcaaag gccatggcta taaggatcac caactcactc 600 ccaccaaaaa agtgaacgag aaatatctga gcaaggcaac ccttgaaaga gatgactttg 660

Page 2870

069269_0225_SL.TXT cgtttactga aaaagtcagc aatcatcttg ggggctgtga cggaagacag acataggtca atgagtgaga ggttagccag caggaagtac atgggagagt gaagatggga gtcagaagcc acagttatga caataagaag gtttccaaac acaattccca catagaatat aaaaaagaac accagtagga atatctggaa ttcctgagaa ttggagagtc ccagaaaaat gaactcagtc accatggagt aatt

720

780

840

900

914 <210> 2584 <211> 302 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (302)..(302) <223> Any amino acid <400> 2584

Met Val Thr Glu Phe Ile Phe Leu Gly Leu Ser Asn Ser Gln Glu Phe 1 5 10 15 Gln Ile Phe Leu Leu Val Phe Phe Phe Ile Phe Tyr Val Gly Ile Val 20 25 30 Phe Gly Asn Leu Leu Ile Val Ile Thr Val Ala Ser Asp Ser His Leu 35 40 45 His Ser Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Leu Ile Asp Leu 50 55 60 Cys Leu Ser Ser Val Thr Ala Pro Lys Met Ile Ala Asp Phe Phe Ser 65 70 75 80 Lys Arg Lys Val Ile Ser Phe Lys Gly Cys Leu Ala Gln Ile Phe Leu 85 90 95 Val His Phe Phe Gly Gly Ser Glu Leu Val Ile Leu Ile Ala Met Ala 100 105 110 Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu Arg Tyr Ser Thr Val

Page 2871

069269_0225_SL.TXT

115 120 125 Met Cys Asp His Val Cys Phe Gly Ile Val Thr Ala Ala Trp Gly Thr 130 135 140 Gly Phe Leu His Ser Val Ser Gln Leu Ala Phe Ala Val Asn Leu Pro 145 150 155 160 Phe Cys Gly Pro Asn Glu Val Asp Ser Phe Tyr Cys Asp Leu Pro Arg 165 170 175 Val Ile Lys Leu Ala Cys Ile Asp Thr Tyr Arg Leu Asp Val Met Val 180 185 190 Ile Ala Asn Ser Gly Val Leu Thr Val Cys Ser Phe Val Phe Leu Ile 195 200 205 Ile Ser Tyr Ala Ile Ile Leu Val Thr Ile Gln Gln Arg Pro Ser Asp 210 215 220 Lys Ser Ser Lys Ala Leu Ser Thr Leu Thr Ala His Ile Thr Val Val 225 230 235 240 Leu Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr Ala Trp Pro Phe Pro 245 250 255 Ile Lys Ser Leu Asp Lys Ser Leu Ala Val Phe Tyr Ser Val Val Thr 260 265 270 Pro Leu Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys Asp Met Lys 275 280 285 Thr Ala Met Arg Arg Leu Ser Lys Trp Asn Val Asn Ser Xaa 290 295 300

<210> 2585 <211> 939 <212> DNA <213> Felis catus

Page 2872

069269_0225_SL.TXT <400> 2585 ttatgacatc tctctagaac ttacaacttg tcgactcagc cttctcattg ctgccttcat 60 atctctgttc cttaaagtat agatggcagg atttaagaca ggagtgacga caaagtccac 120 aatggcaaaa aatgtatcca ttgacttggt aggaaaaggc cacacataga gaaacatgca 180 tggaacaaaa aacaaaacca ctacagtgat gtgagctgac aaagtgatga atgctttgga 240 taaatccttt gaagaatgtt gtctgacagt gatcagaata aagatgtatg atacaattaa 300 gaaaaagaag gtgcccatag atatgaagcc actgttagca gtgaccacaa attctagtct 360 gtaagtgtcc atgcatgcaa gtttaataac cctaggaaaa tcacagtaaa agctccccac 420 atttttaggg ccacagaaag gtaaatttat gacaaaaaca aattgagaca cagcatggat 480 caccccaatg atccaagcag tcattaccaa aagcatgcac attttgagat tcataatagt 540 taagtagtgg agaggcctgc aaattgccgt gtacctgtca tatgccatgg ctatgagcag 600 tatcatctca actcctccca tgacatgaat aaaaaacatt tgtatcatgc aactatggaa 660 ggagatgatt ttgcaatcac tgaaaagatc agagatcatc ctaggaactg tggtagatga 720 aaggcccagg tcaatgaatg ataagttggc cagcaggata tacatgggag agtgtaagtg 780 agaatcaaaa atcactgtaa acataatgaa gaggtttccc aagataattc ccgcatagaa 840 taaagagaag aaaagaaaaa gcaaaacctg cattcccaag gattgtgcaa gtcccagtaa 900 cacaaattca tttaccacag agccatttac ttggtccat 939 <210> 2586 <211> 312 <212> PRT <213> Felis catus <400> 2586

Met 1 Asp Gln Val Asn Gly Ser Val Val Asn Glu Phe Val Leu Leu Gly 5 10 15 Leu Ala Gln Ser Leu Gly Met Gln Val Leu Leu Phe Leu Phe Phe Ser 20 25 30 Leu Phe Tyr Ala Gly Ile Ile Leu Gly Asn Leu Phe Ile Met Phe Thr 35 40 45

Page 2873

Val Ile 50 Phe Asp Ser His Leu 55 069269_0225_SL.TXT His Ser Pro Met Tyr Ile 60 Leu Leu Ala Asn Leu Ser Phe Ile Asp Leu Gly Leu Ser Ser Thr Thr Val Pro Arg 65 70 75 80 Met Ile Ser Asp Leu Phe Ser Asp Cys Lys Ile Ile Ser Phe His Ser 85 90 95 Cys Met Ile Gln Met Phe Phe Ile His Val Met Gly Gly Val Glu Met 100 105 110 Ile Leu Leu Ile Ala Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Leu Thr Ile Met Asn Leu Lys Met Cys Met Leu Leu 130 135 140 Val Met Thr Ala Trp Ile Ile Gly Val Ile His Ala Val Ser Gln Phe 145 150 155 160 Val Phe Val Ile Asn Leu Pro Phe Cys Gly Pro Lys Asn Val Gly Ser 165 170 175 Phe Tyr Cys Asp Phe Pro Arg Val Ile Lys Leu Ala Cys Met Asp Thr 180 185 190 Tyr Arg Leu Glu Phe Val Val Thr Ala Asn Ser Gly Phe Ile Ser Met 195 200 205 Gly Thr Phe Phe Phe Leu Ile Val Ser Tyr Ile Phe Ile Leu Ile Thr 210 215 220 Val Arg Gln His Ser Ser Lys Asp Leu Ser Lys Ala Phe Ile Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Met Phe 245 250 255

Page 2874

Leu Tyr Val Trp 260 Pro Phe Pro 069269_0225_SL.TXT Thr Lys Ser Met Asp Thr 265 Phe 270 Phe Ala Ile Val Asp Phe Val Val Thr Pro Val Leu Asn Pro Ala Ile Tyr Thr 275 280 285 Leu Arg Asn Arg Asp Met Lys Ala Ala Met Arg Arg Leu Ser Arg Gln 290 295 300 Val Val Ser Ser Arg Glu Met Ser

305 310 <210> 2587 <211> 936 <212> DNA <213> Felis catus <400> 2587

tcaacaaaat ttggagttag atatcctttt gtgcagtctt tttatagata accttatgtc 60 tttgttcctt agtgtataga taacaggatt caagacaggg gtaatagcga agtctacaac 120 gaacagattt ttatcaattg aaggtggggg agaaggccag acatacagaa acatgcatgg 180 agtgaaaaac aaaaacacca cagtgatgtg agctgacaaa gtaacaaatg ccttggataa 240 ttctcctgaa gaacgtttcc agacagtgat caaaatgaat gaataggaaa ggattagcag 300 gaagaaggtg cccatgctca tgaagccact gttggcagta acgataaact caaacttggc 360 cgcatctgtg catgcaagtt ttatgatctt aggaaagtca cagtaaaagc tgtccacttt 420 attaggacca caaaaaggca agtttataac aaataaaaac tgagacatag catggatcac 480 cccagttacc catccagtga ttacaaatga aacacatatt ttagggttca tgatgtttag 540 gtagtgaaga ggcttacaga ttgctgtgca cctgtcaaat gccatggcta tgagtaacac 600 catctccact cctcctatga tgtggatgaa gcatatctgt gtcatacaac tttggaaaga 660 aattattttg tattcattta agaggtctgt gattatcttt ggaactgtag tagaggaaag 720 acccacatca atgagggaca ggttggccag caggaagtac atgggagaat gtaggtgcga 780 atcaaaaatt accaaaaaca aaataaaaag gtttcccaag atgaccccta aatacagcaa 840 agaacatatc aaaataagaa aaagtttttt ctcccaagag caagaaaggg ccagtaacac 900

Page 2875

936

069269_0225_SL.TXT aatttcagtg accacagagt catttagtcc acccat <210> 2588 <211> 311 <212> PRT <213> Felis catus

<400> 2588 Ala Met 1 Gly Gly Leu Asn 5 Asp Ser Val Val Thr 10 Glu Ile Val Leu Leu 15 Leu Ser Cys Ser Trp Glu Lys Lys Leu Phe Leu Ile Leu Ile Cys Ser 20 25 30 Leu Leu Tyr Leu Gly Val Ile Leu Gly Asn Leu Phe Ile Leu Phe Leu 35 40 45 Val Ile Phe Asp Ser His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Leu Ile Asp Val Gly Leu Ser Ser Thr Thr Val Pro Lys 65 70 75 80 Ile Ile Thr Asp Leu Leu Asn Glu Tyr Lys Ile Ile Ser Phe Gln Ser 85 90 95 Cys Met Thr Gln Ile Cys Phe Ile His Ile Ile Gly Gly Val Glu Met 100 105 110 Val Leu Leu Ile Ala Met Ala Phe Asp Arg Cys Thr Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Leu Asn Ile Met Asn Pro Lys Ile Cys Val Ser Phe 130 135 140 Val Ile Thr Gly Trp Val Thr Gly Val Ile His Ala Met Ser Gln Phe 145 150 155 160 Leu Phe Val Ile Asn Leu Pro Phe Cys Gly Pro Asn Lys Val Asp Ser 165 170 175

Page 2876

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Phe Tyr Cys Asp Phe Pro Lys Ile Ile Lys Leu Ala Cys Thr 190 Asp Ala 180 185 Ala Lys Phe Glu Phe Ile Val Thr Ala Asn Ser Gly Phe Met Ser Met 195 200 205 Gly Thr Phe Phe Leu Leu Ile Leu Ser Tyr Ser Phe Ile Leu Ile Thr 210 215 220 Val Trp Lys Arg Ser Ser Gly Glu Leu Ser Lys Ala Phe Val Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Phe Leu Phe Phe Thr Pro Cys Met Phe 245 250 255 Leu Tyr Val Trp Pro Ser Pro Pro Pro Ser Ile Asp Lys Asn Leu Phe 260 265 270 Val Val Asp Phe Ala Ile Thr Pro Val Leu Asn Pro Val Ile Tyr Thr 275 280 285 Leu Arg Asn Lys Asp Ile Arg Leu Ser Ile Lys Arg Leu His Lys Arg 290 295 300 Ile Ser Asn Ser Lys Phe Cys

305 310 <210> 2589 <211> 924 <212> DNA <213> Felis catus <400> 2589 cataatgtcc ccatttgctc aatcttttta ttgatatctt tatgtctttg ttccgtaatg tatagatggc aggattcaag acaggggtga tagcaaagtc aacaatgaat aggtatttat caattgatga cgtggggaaa ggccatacat agagaaacat gcatggagtg aaaaatagaa ccaccacagt gatgtgagct gacagagtga caaatgcttt ggataagtct cctgaagaac gtttccagac agtgaccaaa atgaagatat aggaaaggat tagcaggaag aaggtgccca

120

180

240

300

Page 2877

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tgctcatgaa gccactgttg gcagcaataa caaactcaaa cttggctcca tctgtgcatg 360 caagttttat gacctgggaa agtcacagta aaagctgtct actttattag gaccacaaaa 420 aggcaagttt ataatgaaag caaactggga catagcatgg atcacccaat gacccagcca 480 gcaattacaa atgaaacaca tattttaggg ttcatgatgt tcaggtagcg aagaggctta 540 cagattgctg tgtacctgtc aaatgccatg gcgatgagta acaccatctc cactcctccc 600 atgatgtgga tgaagcatat ctgtgtcata caactttgga aagaaattat cttatactca 660 tttagaaggt ctgtaatcat ctttggaact gtggtagagg aaagccccac atcaatgagg 720 gataggttgg ccagcaggaa gtacatagga gaatgtaaat gagaatcaaa aattaccaaa 780 aagaaaatga aaagatttcc caggatgatc cccaaataaa tcaaggaaaa tatcaacatg 840 agaaaaactt tagtttccca agaactagcg agtcccaaca acataaactc agaaacaaca 900 gattcattta gtccattcat tgac 924

<210> 2590 <211> 153 <212> PRT <213> Felis catus <400> 2590

Ser 1 Met Asn Gly Leu Asn Glu Ser Val Val Ser Glu Phe Met Leu 15 Leu 5 10 Gly Leu Ala Ser Ser Trp Glu Thr Lys Val Phe Leu Met Leu Ile Phe 20 25 30 Ser Leu Ile Tyr Leu Gly Ile Ile Leu Gly Asn Leu Phe Ile Phe Phe 35 40 45 Leu Val Ile Phe Asp Ser His Leu His Ser Pro Met Tyr Phe Leu Leu 50 55 60 Ala Asn Leu Ser Leu Ile Asp Val Gly Leu Ser Ser Thr Thr Val Pro 65 70 75 80 Lys Met Ile Thr Asp Leu Leu Asn Glu Tyr Lys Ile Ile Ser Phe Gln 85 90 95

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Ser Cys Met Thr Gln Ile Cys Phe Ile 105 His Ile Met Gly Gly 110 Val Glu 100 Met Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Thr Ala Ile Cys 115 120 125 Lys Pro Leu Arg Tyr Leu Asn Ile Met Asn Pro Lys Ile Cys Val Ser 130 135 140 Phe Val Ile Ala Gly Trp Val Ile Gly 145 150

<210> 2591 <211> 894 <212> DNA <213> Felis catus <400> 2591 acttatcagt ctctttatgg cattcctaat gtctttattt ctcagtgtgt aaatggctgg 60 attcaggaga ggtgtgatta ctgtgtaaaa cacagcaaga aacttgtcca cccaagtgat 120 gctaagtggc cacagataga tgaagatgca gggtccaaag aacagcagca ccactgtgat 180 gtgggcggta caggtagaca gtgcctttga tgctccattc ttagagtgaa ggcgcactgt 240 tactaggata taggtgtagg agatgagtag gataatgaag caagttgttg ccaagacccc 300 actgtcagca tttatcaata ttcctagagt atgtgtatcc atgcaggcca atttgatcac 360 caaagggata tcacagaaaa aactgtccac tgttctgggt ccacagaagg gcagatctaa 420 aatcatagct agttggctca tggcatgcac aaagccaatg acccatgata tcaaaaccag 480 ccagaggcac ttttgtctgt ccatgatgct ggaataatgg agtggcttgc agatggccac 540 ataacggtca taggccattg tcacgagtag caccatctca ccccctgcaa aaaaatgcac 600 acagaggatc tggctcatgc agccaccgaa ggagatggtc ttattatcct ttaggaagtc 660 tatggtcagt ttaggggtag ttactgagga aaggcagaag tccacaaatg agagattggc 720 taagaggaag tacatcgggg agtggagatg agggtcagtg atgaataaga acacgacaag 780 gaggttgccc acaaccgtca tcaggtaaag catggaaaat ggcagtaaga ggaagttctg 840

Page 2879

894

069269_0225_SL.TXT gagctctctt gaattacaaa gtccacgaaa aataaactca gacaccacag actg <210> 2592 <211> 298 <212> PRT <213> Felis catus

<400> 2592 Gln 1 Ser Val Val Ser 5 Glu Phe Ile Phe Arg Gly Leu Cys Asn Ser Arg 10 15 Glu Leu Gln Asn Phe Leu Leu Leu Pro Phe Ser Met Leu Tyr Leu Met 20 25 30 Thr Val Val Gly Asn Leu Leu Val Val Phe Leu Phe Ile Thr Asp Pro 35 40 45 His Leu His Ser Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Phe Val 50 55 60 Asp Phe Cys Leu Ser Ser Val Thr Thr Pro Lys Leu Thr Ile Asp Phe 65 70 75 80 Leu Lys Asp Asn Lys Thr Ile Ser Phe Gly Gly Cys Met Ser Gln Ile 85 90 95 Leu Cys Val His Phe Phe Ala Gly Gly Glu Met Val Leu Leu Val Thr 100 105 110 Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Ser 115 120 125 Ser Ile Met Asp Arg Gln Lys Cys Leu Trp Leu Val Leu Ile Ser Trp 130 135 140 Val Ile Gly Phe Val His Ala Met Ser Gln Leu Ala Met Ile Leu Asp 145 150 155 160 Leu Pro Phe Cys Gly Pro Arg Thr Val Asp Ser Phe Phe Cys Asp Ile 165 170 175

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Pro Leu Val Ile 180 Lys Leu Ala Cys Met Asp Thr His Thr Leu Gly Ile 185 190 Leu Ile Asn Ala Asp Ser Gly Val Leu Ala Thr Thr Cys Phe Ile Ile 195 200 205 Leu Leu Ile Ser Tyr Thr Tyr Ile Leu Val Thr Val Arg Leu His Ser 210 215 220 Lys Asn Gly Ala Ser Lys Ala Leu Ser Thr Cys Thr Ala His Ile Thr 225 230 235 240 Val Val Leu Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr Leu Trp Pro 245 250 255 Leu Ser Ile Thr Trp Val Asp Lys Phe Leu Ala Val Phe Tyr Thr Val 260 265 270 Ile Thr Pro Leu Leu Asn Pro Ala Ile Tyr Thr Leu Arg Asn Lys Asp 275 280 285 Ile Arg Asn Ala Ile Lys Arg Leu Ile Ser 290 295

<210> 2593 <211> 940 <212> DNA <213> Felis catus <400> 2593

ttagcagagt ctgacataat gtccttattt gctcaatctt tttatggcta cctttatgtc 60 tttatttctt aacgtatata tgatgggatt taagatgggt gtgatagcaa agtcagcaat 120 gaacaggtat ttatcaactg acgatgtggg gaaaggccat acatagagaa acatgcatgg 180 agtgaaaaat agaaccacca cagtgatgtg agctgacaga gtgacaaatg ctttggataa 240 gtctcctgaa gaacgtttcc agacagtgac caaaataaag atataggaaa ggattagcag 300 gaagaaggtg cccatgctca tgaagccact gttggcagca ataataaact caaacttggc 360 tccatctgtg catgcaagtt ttatgattct gggaaagtca cagtaaaagc tgtctacttt 420

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attaggaccg caaaagggca agtttataat gaaagcaaac tgggacatag catggatcac 480 cccaatgacc cagccagcaa ttacaaatga aacacatatt ttagggttca tgatgttcag 540 gtagcgaaga ggcttacaga ttgctgtgta cctgtcaaat gccatggcga tgagtaacac 600 catctccact cctcccatga tgtggatgaa gcatatctgt gtcatacaac tttggaaaga 660 aattatcttg tgttcattta aaaggtctct aatcattttg gggactgtgg tagaggcaac 720 ccccacgtca atgaaggaca gattggccag taggaagtac ataggagaat gtaaatgaga 780 atcaaaaatt accaaaaaga caatgaagag atttcccagg atgattccta aatagatcaa 840 ggaaaatatt aatgtaagaa aaactttagt ttcccaagaa ctagagagtc caagcaacac 900 aaactcagaa accatagaat tatttaatcc atccattgac 940

<210> 2594 <211> 303 <212> PRT <213> Felis catus

<400> 2594 Asn Ser Met Val Ser Glu Phe Val Leu Leu Gly Met Asp 1 Gly Leu Asn 5 10 15 Leu Ser Ser Ser Trp Glu Thr Lys Val Phe Leu Thr Leu Ile Phe Ser 20 25 30 Leu Ile Tyr Leu Gly Ile Ile Leu Gly Asn Leu Phe Ile Val Phe Leu 35 40 45 Val Ile Phe Asp Ser His Leu His Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ser Phe Ile Asp Val Gly Val Ala Ser Thr Thr Val Pro Lys 65 70 75 80 Met Ile Arg Asp Leu Leu Asn Glu His Lys Ile Ile Ser Phe Gln Ser 85 90 95 Cys Met Thr Gln Ile Cys Phe Ile His Ile Met Gly Gly Val Glu Met 100 105 110

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Val Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Thr Ala Ile Cys Lys 115 120 125 Pro Leu Arg Tyr Leu Asn Ile Met Asn Pro Lys Ile Cys Val Ser Phe 130 135 140 Val Ile Ala Gly Trp Val Ile Gly Val Ile His Ala Met Ser Gln Phe 145 150 155 160 Ala Phe Ile Ile Asn Leu Pro Phe Cys Gly Pro Asn Lys Val Asp Ser 165 170 175 Phe Tyr Cys Asp Phe Pro Arg Ile Ile Lys Leu Ala Cys Thr Asp Gly 180 185 190 Ala Lys Phe Glu Phe Ile Ile Ala Ala Asn Ser Gly Phe Met Ser Met 195 200 205 Gly Thr Phe Phe Leu Leu Ile Leu Ser Tyr Ile Phe Ile Leu Val Thr 210 215 220 Val Trp Lys Arg Ser Ser Gly Asp Leu Ser Lys Ala Phe Val Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Val Leu Phe Phe Thr Pro Cys Met Phe 245 250 255 Leu Tyr Val Trp Pro Phe Pro Thr Ser Ser Val Asp Lys Tyr Leu Phe 260 265 270 Ile Ala Asp Phe Ala Ile Thr Pro Ile Leu Asn Pro Ile Ile Tyr Thr 275 280 285 Leu Arg Asn Lys Asp Ile Lys Val Ala Ile Lys Arg Leu Ser Lys 290 295 300

<210> 2595 <211> 927

Page 2883

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 2595

aattactctc cagtgtctga atttgtgttg ctgggacttt ctacctatag accagtgcag 60 cattttctcc ttgctttctc tgcagtgttt tatgtaacaa ttgttctggg aaaccttttg 120 gttgtgttcg cagtgacctt tgacccattc ttacattctc ccatgtactt ccttttagcc 180 aatctctcat tcattgattt gtgtttttct accttaacag ttcctaagat gattcataac 240 ctatactctg ggtacaaaac catatccttt cagggctgtg tcatccagat atttgccctt 300 catgtcctgg gtggatccga gatggtcctg ctcatcgcca tggccttgga cagatatgtg 360 gccatatgca agcccctcca ctacctgatt atcatgagcc cacagatgtg cattttgctt 420 ctgtccggtg cttgggttat tggcctcatt catgcagtgg tccaggtagc ttttgttgtc 480 catttgcctt tttgcggtcc taatgagata gatagctttt actgtgacct tccttggttt 540 atcaaacttg cctgcaccga cacctacaga atggaattca tggttactgc caacagtggg 600 ttcatttcca tgggcacctt cttcttattg ctcatctcct atatcttcat cctggtcact 660 gtatggaaac gttcctcagg tggtttgtct aaagcctttt ctactctgtc agctcacatc 720 actgtggtgg ttttgttctt cggaccgtgc atctttgttt atgtgtggcc atttcccaca 780 gtgccagtgg ataagtttct tgccattttg gactttatga tcacacccat tctgaatccc 840 attatctaca cgttgaggaa caaggacatg aagatggcaa tgaaaagact gagtagtcaa 900 ttcctgagtt tgagaatgat ctcctaa 927

<210> 2596 <211> 308 <212> PRT <213> Felis catus <400> 2596

Asn Tyr Ser Pro Val Ser Glu Phe Val Leu Leu Gly Leu Ser Thr Tyr 1 5 10 15 Arg Pro Val Gln His Phe Leu Leu Ala Phe Ser Ala Val Phe Tyr Val 20 25 30 Thr Ile Val Leu Gly Asn Leu Leu Val Val Phe Ala Val Thr Phe Asp Page 288 4

069269_0225_SL.TXT 40 45

Pro Phe Leu His Ser Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Phe 50 55 60 Ile Asp Leu Cys Phe Ser Thr Leu Thr Val Pro Lys Met Ile His Asn 65 70 75 80 Leu Tyr Ser Gly Tyr Lys Thr Ile Ser Phe Gln Gly Cys Val Ile Gln 85 90 95 Ile Phe Ala Leu His Val Leu Gly Gly Ser Glu Met Val Leu Leu Ile 100 105 110 Ala Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr 115 120 125 Leu Ile Ile Met Ser Pro Gln Met Cys Ile Leu Leu Leu Ser Gly Ala 130 135 140 Trp Val Ile Gly Leu Ile His Ala Val Val Gln Val Ala Phe Val Val 145 150 155 160 His Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp Ser Phe Tyr Cys Asp 165 170 175 Leu Pro Trp Phe Ile Lys Leu Ala Cys Thr Asp Thr Tyr Arg Met Glu 180 185 190 Phe Met Val Thr Ala Asn Ser Gly Phe Ile Ser Met Gly Thr Phe Phe 195 200 205 Leu Leu Leu Ile Ser Tyr Ile Phe Ile Leu Val Thr Val Trp Lys Arg 210 215 220 Ser Ser Gly Gly Leu Ser Lys Ala Phe Ser Thr Leu Ser Ala His Ile 225 230 235 240 Thr Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Val Tyr Val Trp

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245 250 255 Pro Phe Pro Thr Val Pro Val Asp Lys Phe Leu Ala Ile Leu Asp Phe 260 265 270 Met Ile Thr Pro Ile Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys 275 280 285 Asp Met Lys Met Ala Met Lys Arg Leu Ser Ser Gln Phe Leu Ser Leu 290 295 300

Arg Met Ile Ser 305 <210> 2597 <211> 927 <212> DNA <213> Felis catus <400> 2597

tcagcaaacc atgtgacgac tcagtaacct cctcatggaa gcttttactt cctggttgcg 60 aagggtataa atcacagggt tcatcaaagg aaagatcact gtgtgaaaga gagaaaccac 120 tttgtcggct gggaaagctc tgaagggacg agtatagatg aagatggcag gtccaaacat 180 gagaaacaca atgataatgt gtgtggtaca tgtggaaaga gccttgtgtt tgccttcaga 240 ggtgtgtccc ttcacacgat agaggatgac agcataagag gccagaagcc ccaggaagca 300 cagcagggta agcaggccac tgttggagac catcaggagc tccaccacaa aggtgtctgt 360 gcaggccagc ttgatgacct gtggcacatc acagaagaag ttatccagct ggtttgggcc 420 acagaagggc aagtggagaa taagggctac ttgcacaatg gaatgagtaa agcccccaag 480 ccacagagcc aacagcaagg cattgcagat tctagggttc ataacagtgg tatagtgcaa 540 aggatgacaa atggccatgt agcggtcaaa ggccatcaca acaagaagga acatctcccc 600 tgccccaaga aagtgcaaga aaaaaagctg agtgatgcag cccctgtagg agattatttt 660 cttctcagag aggaagtcca tcagcatcct gggggccaca atgaaggagt aggatgcatc 720 caggaaagcc aagttgccca gaaagaagta gaggggggct gtgaggccag ggtctgatct 780 gatggtgagg atgatgagta gatttccagg gagaatgatg aggtagaaaa ctaagactag 840

Page 2886

069269_0225_SL.TXT cacaaagacc aggagttgag cctgttgaga ctgggtgaga ccaaggagga taaattctgt caccactgtg ctgttctccc tctccat

900

927 <210> 2598 <211> 308 <212> PRT <213> Felis catus

<400> 2598 Ser Thr Val Val Thr Glu Phe Ile Leu Leu Gly Met Glu 1 Arg Glu Asn 5 10 15 Leu Thr Gln Ser Gln Gln Ala Gln Leu Leu Val Phe Val Leu Val Leu 20 25 30 Val Phe Tyr Leu Ile Ile Leu Pro Gly Asn Leu Leu Ile Ile Leu Thr 35 40 45 Ile Arg Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg 65 70 75 80 Met Leu Met Asp Phe Leu Ser Glu Lys Lys Ile Ile Ser Tyr Arg Gly 85 90 95 Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Ala Gly Glu Met 100 105 110 Phe Leu Leu Val Val Met Ala Phe Asp Arg Tyr Met Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Thr Val Met Asn Pro Arg Ile Cys Asn Ala Leu 130 135 140 Leu Leu Ala Leu Trp Leu Gly Gly Phe Thr His Ser Ile Val Gln Val 145 150 155 160

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Ala Leu Ile Leu His 165 Leu Pro Phe Cys Gly 170 Pro Asn Gln Leu Asp 175 Asn Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Val Val Glu Leu Leu Met Val Ser Asn Ser Gly Leu Leu Thr Leu 195 200 205 Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Tyr Arg 210 215 220 Val Lys Gly His Thr Ser Glu Gly Lys His Lys Ala Leu Ser Thr Cys 225 230 235 240 Thr Thr His Ile Ile Ile Val Phe Leu Met Phe Gly Pro Ala Ile Phe 245 250 255 Ile Tyr Thr Arg Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser 260 265 270 Leu Phe His Thr Val Ile Phe Pro Leu Met Asn Pro Val Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Ala Ser Met Arg Arg Leu Leu Ser Arg 290 295 300 His Met Val Cys

305 <210> 2599 <211> 932 <212> DNA <213> Felis catus <400> 2599 ttctatgtgg agataacatt ttggaactgt aattttctca tggcctcttt cattttctga tttctcaggg tataaataat aggatttagt aagggtgtga aaacagtgta aaatacagca aggactttat ttcctgagaa gctattgaat ggccaggcat agataaaaat acaaggtcca

120

180

Page 2888

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aagaacagag tgaccacaat catgtgtgca gacagtgtgg acagtgcctt ggagagacct 240 cccgatgatt tttgttgtac ggtgatcagg atgacaatgt aggagacaag aaggaggatg 300 aaacagatga atgagagcag cccactatca gcaatgacaa ataattccag ggtatatgtt 360 tccatacaag caagcttaat cacaagggga aggtcacaaa atatattgtc tatgacattg 420 gggccacaga aaggcaagtt tactgttaat accatctggc tcatggtgtg tataaaacca 480 attatccatg aaagtatcat aaacccactc aacagcctgt ggctcatgat tgtcctgtag 540 tgcaggggtt tacatatggc tacatatctg tcaaaggcca tagctatcaa aagagtcatc 600 tcagcacccc caaagaagtg cataaagaac atctgagtca tgcagcccca taaggagatg 660 atcttgtgtt cactgagtaa gtctgtgatc atcttgggtg tggtgactgt ggagagacac 720 atgtccaaaa aagagaggtt tccaaggagg aagtacatgg gagaatgaag ggtggaacta 780 aatgtcactg tgaccataat gagaacattc cccaacacag tagcactgta gattaaggag 840 aatgttacaa agaagaaaat ccgaagttcc cattgtccag aaaatcctag taaaataaac 900 tcagtcacta cagatccatt tttaagatcc at 932

<210> 2600 <211> 309 <212> PRT <213> Felis catus <400> 2600

Met Asp Leu Lys Asn Gly Ser Val Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Ser Gly Gln Trp Glu Leu Arg Ile Phe Phe Phe Val Thr Phe Ser 20 25 30 Leu Ile Tyr Ser Ala Thr Val Leu Gly Asn Val Leu Ile Met Val Thr 35 40 45 Val Thr Phe Ser Ser Thr Leu His Ser Pro Met Tyr Phe Leu Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Met Cys Leu Ser Thr Val Thr Thr Pro Lys 65 70 75 80

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Met Ile Thr Asp Leu 85 Leu Ser Glu His Lys Ile Ile Ser Leu Trp Gly 90 95 Cys Met Thr Gln Met Phe Phe Met His Phe Phe Gly Gly Ala Glu Met 100 105 110 Thr Leu Leu Ile Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Arg Thr Ile Met Ser His Arg Leu Leu Ser Gly Phe 130 135 140 Met Ile Leu Ser Trp Ile Ile Gly Phe Ile His Thr Met Ser Gln Met 145 150 155 160 Val Leu Thr Val Asn Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Asn 165 170 175 Ile Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Met Glu Thr 180 185 190 Tyr Thr Leu Glu Leu Phe Val Ile Ala Asp Ser Gly Leu Leu Ser Phe 195 200 205 Ile Cys Phe Ile Leu Leu Leu Val Ser Tyr Ile Val Ile Leu Ile Thr 210 215 220 Val Gln Gln Lys Ser Ser Gly Gly Leu Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Ser Ala His Met Ile Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Ala Trp Pro Phe Asn Ser Phe Ser Gly Asn Lys Val Leu Ala 260 265 270 Val Phe Tyr Thr Val Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr Thr 275 280 285

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Leu Arg Asn Gln Lys Met Lys Glu Ala Met Arg Lys Leu Gln Phe Gln 290 295 300

Asn Val Ile Ser Thr 305 <210> 2601 <211> 708 <212> DNA <213> Felis catus <400> 2601 tctttattcc tgaatgtgta gatgattgga tttaaaaggg gagtaaaaat ggtgtaaaac 60 acagaaagga tcttatctat ggagatcttg ctgaatggcc atatgtagat aaagatgcaa 120 ggtccaaaga acagcaccac cactgtaatg tgggttgaga gagtggacaa agccttggaa 180 gacctggtgg aggagtgacg ctggacagta attagaatga tgctatagga gatgaacaga 240 aaggtgaaac agaacaaagc aagtagtcca ctgaatgcaa tgaccaatag ctccaggatg 300 taagtgtcag tgcaggcaag tctgatgacc cgaggcagat cacaaaaaaa aactatccac 360 aacattggga ccacagaatg gtaaagttac tgtgaacacc atttggctca tagtgtgtac 420 aaaaccagtg gtccaggaaa aaagtgcaag tccaatgcaa acatgatggt tcatgatatt 480 tttgtaatgg agaggtttgc aaatagcaat gaatctatca attgccatgg ctacaagcaa 540 catcatctca cttccaccta aaaggtgaag gaagaacatc tgggccatgc agcctttata 600 ggagatagcc ttatattcac taattaggtt acagatcatt ttaggagtag caaaggaggc 660 cagggacata tcaataaagg agaggttggc cagcaggaag tacattgg 708 <210> 2602 <211> 122 <212> PRT <213> Felis catus

<400> 2602 Pro Met Tyr Phe Leu Leu Ala Asn Leu Ser Phe Ile Asp Met Ser Leu 1 5 10 15

Ala Ser Phe Ala Thr Pro Lys Met Ile Cys Asn Leu Ile Ser Glu Tyr 20 25 30

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Lys Ala Ile Ser Tyr Lys 35 Gly Cys Met Ala Gln Met Phe Phe Leu His 40 45 Leu Leu Gly Gly Ser Glu Met Met Leu Leu Val Ala Met Ala Ile Asp 50 55 60 Arg Phe Ile Ala Ile Cys Lys Pro Leu His Tyr Lys Asn Ile Met Asn 65 70 75 80 His His Val Cys Ile Gly Leu Ala Leu Phe Ser Trp Thr Thr Gly Phe 85 90 95 Val His Thr Met Ser Gln Met Val Phe Thr Val Thr Leu Pro Phe Cys 100 105 110 Gly Pro Asn Val Val Asp Ser Phe Phe Leu 115 120

<210> 2603 <211> 897 <212> DNA <213> Felis catus <400> 2603

tgaagcaaaa tactctgaag tcttaatttg tattcctggg actttctacc tatggaccag 60 tgctacattt tctccttgct ttctctactg ggttttctgt aacaatggtc ctgggaaacc 120 tccttgtgtt tacagtgacc tttgatcctc atttacatta ccccccatgt acttcctttt 180 agctaaactc tcctttattg atttgtgtct ttccacctta agggtttcta agatgattgt 240 gacctgtatt ctgggcacaa aaccacatac tttcaggggt gtgtcaccag atgtttgccc 300 ttcatgtcct ggctggatct gagatggtcc tgcttattgc tctggccttg gacagatatg 360 tggccatatg caagcccctc cactacctga ctatcatgag cccacagatg tgcattttgc 420 ttctgtccag tgcttgggtt attggcctca ttcatgcagt ggtccagtta gcttttgttg 480 tccatttgcc tctttgtggt cctaatgaga taaatagctt ttactgtgac cttccttggc 540 ttatcaaact tgcctgcaca gacacctaca gaatggaatt catggttaat gccaacagtg 600

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069269_0225_SL.TXT ggttcgtttc catgggcacc ttcttcttag tgcttatctc ctatatcttc atcctggtca 660 ctgtatagaa atgttcctca tgtggtttgt ctaaagcctt ttctactctg tcagctcaca 720 tgactgtggt ggttttgttt ttcggaccgt gcatctttgt ttatgtgtgg ccatttccca 780 cagtgccagt ggataagttt tcttgccatg ttggacttta tgatcacacc cattctgaat 840 cccattatct acacattgag gaacaaggac atgaagttgg caatgaggag acggagt 897 <210> 2604 <211> 64 <212> PRT <213> Felis catus

<400> 2604 Cys Gln Leu His Val Leu Val Pro Gln Cys Val Thr 1 Pro Ser Pro His 5 10 15 Asp Asn Gly Ile Gln Asn Gly Cys Asp His Lys Val Gln His Gly Lys 20 25 30 Lys Thr Tyr Pro Leu Ala Leu Trp Glu Met Ala Thr His Lys Gln Arg 35 40 45 Cys Thr Val Arg Lys Thr Lys Pro Pro Gln Ser Cys Glu Leu Thr Glu 50 55 60

<210> 2605 <211> 858 <212> DNA <213> Felis catus <400> 2605

tgtgtttggt cttcagtcta ctaatggcta ctttcatctc ctgattcctt agagtgtaaa 60 taatggggtt cagtaaaggt gtaataattg aataaaacac agaaagaaat ttatccactg 120 aaaagctact gaatggccaa gcataaatga agataattgg cccaaagaac agagtgacca 180 cagtaatgtg agcggacagt gtggacagag ccttggagag tccaccagaa gatcgacgtc 240 ggacagttac cagaatgaca gtgtaggaaa tgagcaagag tatgaagcag atgaaagaca 300 acagtccact gtcagcagtt accagcaact ccagaacata agtctcagtg caggcaagtt 360 ttagcactag gggaaggtca caaaaaatat cgtccactat attgggacca cagaagggca 420

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agttgatagt aaaaaccatc tggctcatcg tatgcacaaa accaactgcc caggacagca 480 gcacagagcc ggtgaggact cggcggttca tgatggatgt gtagtgaaga ggtttgcata 540 ttgcaatgta ccgatcaaca gccatgacta tgagaagagt catctcactg ccccctaaaa 600 agtggaggaa gaacatctga gccatacagc cccacaagga aatagttttg ttctccttga 660 gaaaatctgt gaccatctta ggggctgtga ttgtagaaat acacatatcc agaaaggaga 720 gatttccaag gaggaagtac attggtgtgg agtacagatg tgagtcaaag gttatggtga 780 ccacgatgag aaagtttcct gccacaatag ctgcataggc caacaaaaat atgaaaaaaa 840 agaaaatttc aagttccc 858

<210> 2606 <211> 286 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (286)..(286) <223> Any amino acid

<400> 2606 Phe Phe 5 Phe Phe Ile Phe Leu Leu Ala Tyr Ala Ala Glu Leu 1 Glu Ile 10 15 Ile Val Ala Gly Asn Phe Leu Ile Val Val Thr Ile Thr Phe Asp Ser 20 25 30 His Leu Tyr Ser Thr Pro Met Tyr Phe Leu Leu Gly Asn Leu Ser Phe 35 40 45 Leu Asp Met Cys Ile Ser Thr Ile Thr Ala Pro Lys Met Val Thr Asp 50 55 60 Phe Leu Lys Glu Asn Lys Thr Ile Ser Leu Trp Gly Cys Met Ala Gln 65 70 75 80 Met Phe Phe Leu His Phe Leu Gly Gly Ser Glu Met Thr Leu Leu Ile 85 90 95

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Val Met Ala Val 100 Asp Arg Tyr Ile Ala Ile Cys 105 Lys Pro Leu 110 His Tyr Thr Ser Ile Met Asn Arg Arg Val Leu Thr Gly Ser Val Leu Leu Ser 115 120 125 Trp Ala Val Gly Phe Val His Thr Met Ser Gln Met Val Phe Thr Ile 130 135 140 Asn Leu Pro Phe Cys Gly Pro Asn Ile Val Asp Asp Ile Phe Cys Asp 145 150 155 160 Leu Pro Leu Val Leu Lys Leu Ala Cys Thr Glu Thr Tyr Val Leu Glu 165 170 175 Leu Leu Val Thr Ala Asp Ser Gly Leu Leu Ser Phe Ile Cys Phe Ile 180 185 190 Leu Leu Leu Ile Ser Tyr Thr Val Ile Leu Val Thr Val Arg Arg Arg 195 200 205 Ser Ser Gly Gly Leu Ser Lys Ala Leu Ser Thr Leu Ser Ala His Ile 210 215 220 Thr Val Val Thr Leu Phe Phe Gly Pro Ile Ile Phe Ile Tyr Ala Trp 225 230 235 240 Pro Phe Ser Ser Phe Ser Val Asp Lys Phe Leu Ser Val Phe Tyr Ser 245 250 255 Ile Ile Thr Pro Leu Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Gln 260 265 270 Glu Met Lys Val Ala Ile Ser Arg Leu Lys Thr Lys His Xaa 275 280 285

<210> 2607 <211> 924

Page 2895

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 2607 atggaaaggg tgaaccattc agtggtgtct gagttcattt tgctgggact ttccaaatct 60 cagaatcttc agattttatt cttcctagga ttctctgtgg tctatgctgg gattgtgtta 120 ggaaaccttc tcatcttggt caccgtgacc tttgactcac gccttcacac accaatgtat 180 tttctgctta tcaatctctc ctgtatggat atgatcttgg cttcttctgc tacccctaag 240 atgattgtgg atttcctccg aaagcggaag accatctctt ggtggggatg ttattctcag 300 atgttcttca tccacctcct aggtgggagt gagatgatgt tgcttgtagc catggcaata 360 gacaggtatg ttgccatatg caaacccctc cattacatgt ccatcatgaa cccccgagtg 420 cttggtgggc tgctgctatc ctcctacaca gttggatttg tgcactcatc tagtcaaatg 480 gctttcatgt tgaatttgcc cttctgtggt cccaacgtgg tggacagctt cttctgtgac 540 cttccccttg tgatcaaact cgcctgcaag gataccttca tgctacaact gctggtcatt 600 gctgacagtg gcctcctgtc cctggtctgc ttcctcctct tgcttgtctc ctacatggtc 660 atcatacact cagtcaggca ccgtgctgct agtggttccg ccaaggcctt ctccactctc 720 tcggcacaca tcacggttgt gactttatcg tttgccccat gtgtctttat ctatgtatgg 780 cccttcagca gatactctgt agataaaatt ctttctgtgt tttatacaat tttcacacct 840 ctcttaaatc ctattattta tacattaagg aatcaagaag taaaagcagc cattaagaag 900 ataagaactc gacacataaa ttca 924 <210> 2608 <211> 308 <212> PRT <213> Felis catus

<400> 2608 Met Glu Arg Val Asn His Ser Val Val Ser Glu Phe Ile Leu Leu Gly 1 5 10 15

Leu Ser Lys Ser Gln Asn Leu Gln Ile Leu Phe Phe Leu Gly Phe Ser 20 25 30

Val Val Tyr Ala Gly Ile Val

Leu Gly Asn Leu Leu Ile Page 2896

Leu Val Thr

069269_0225_SL.TXT 40 45

Val Thr Phe Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ile 50 55 60 Asn Leu Ser Cys Met Asp Met Ile Leu Ala Ser Ser Ala Thr Pro Lys 65 70 75 80 Met Ile Val Asp Phe Leu Arg Lys Arg Lys Thr Ile Ser Trp Trp Gly 85 90 95 Cys Tyr Ser Gln Met Phe Phe Ile His Leu Leu Gly Gly Ser Glu Met 100 105 110 Met Leu Leu Val Ala Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Met Ser Ile Met Asn Pro Arg Val Leu Gly Gly Leu 130 135 140 Leu Leu Ser Ser Tyr Thr Val Gly Phe Val His Ser Ser Ser Gln Met 145 150 155 160 Ala Phe Met Leu Asn Leu Pro Phe Cys Gly Pro Asn Val Val Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Lys Asp Thr 180 185 190 Phe Met Leu Gln Leu Leu Val Ile Ala Asp Ser Gly Leu Leu Ser Leu 195 200 205 Val Cys Phe Leu Leu Leu Leu Val Ser Tyr Met Val Ile Ile His Ser 210 215 220 Val Arg His Arg Ala Ala Ser Gly Ser Ala Lys Ala Phe Ser Thr Leu 225 230 235 240 Ser Ala His Ile Thr Val Val Thr Leu Ser Phe Ala Pro Cys Val Phe

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245 250 255

Ile Tyr Val Trp 260 Pro Phe Ser Arg Tyr Ser Val Asp Lys Ile Leu Ser 265 270 Val Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Ile Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Ala Ala Ile Lys Lys Ile Arg Thr Arg 290 295 300 His Ile Asn Ser

305 <210> 2609 <211> 926 <212> DNA <213> Felis catus <400> 2609 tgcagaatta ttccttggtg tcagaatttg tgttgtatgg actctgcact tcacagcatc tccaacattt tttctttata tttttctctg ggatctatgt ggtcactgtg ctgggtaacc tcattattgt ggtcactgta atttctgacc cccacttgca ctcttcccct atgtacttcc tgctgggaaa tctatccttc ttggacatat ggctagcctc atttgccacc cccaagatga tcagggactt tctcagtgat cgaaagctca actcctttgg aggatgtatg gctcagatct tcttcttgca ctttattggt ggggctgaga tggtgcttct ggtttccatg gcctatgaca gatatgtggc tatatgcatt cctttgtatt acatgactat gatgagctgg cagacctaca tggatctggt gttcatttca tggatcgttg gatttgtgca ctccatcagc caagtagcct ttactgtgag tttaccttac tgtggcccca gtgaggtgga cagcttcttt tgtgaccttc ctcttgtgat caagcttgcc tgcatggaca cttatgtctt gggtatactc atgatctcag acagtggggt tgctctctat gagctgtttt gtgctcctct tggtctacta cactgttgtc atcatcactg tccaacaaca tgctgctggt ggggtatcca aagcactctc tacttgctct gcatgtatca tggtaatcat gctctctctt ctttgggccc tgcattttca tttgtgtgtg gcctttcagt tggttctttg tggacaagct tctgtttgtg tttttacacc atttttactc

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069269_0225_SL.TXT ctctcttgaa cccccttatc tacacattga gaaataaaga gatgaaaaca gctatgaaga agctgtgaac caacatgtga cttctc

900

926 <210> 2610 <211> 301 <212> PRT <213> Felis catus <400> 2610

Gln Asn 1 Tyr Ser Leu Val Ser Glu Phe Val Leu Tyr Gly Leu Cys Thr 5 10 15 Ser Gln His Leu Gln His Phe Phe Phe Ile Phe Phe Ser Gly Ile Tyr 20 25 30 Val Val Thr Val Leu Gly Asn Leu Ile Ile Val Val Thr Val Ile Ser 35 40 45 Asp Pro His Leu His Ser Ser Pro Met Tyr Phe Leu Leu Gly Asn Leu 50 55 60 Ser Phe Leu Asp Ile Trp Leu Ala Ser Phe Ala Thr Pro Lys Met Ile 65 70 75 80 Arg Asp Phe Leu Ser Asp Arg Lys Leu Asn Ser Phe Gly Gly Cys Met 85 90 95 Ala Gln Ile Phe Phe Leu His Phe Ile Gly Gly Ala Glu Met Val Leu 100 105 110 Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ile Pro Leu 115 120 125 Tyr Tyr Met Thr Met Met Ser Trp Gln Thr Tyr Met Asp Leu Val Phe 130 135 140 Ile Ser Trp Ile Val Gly Phe Val His Ser Ile Ser Gln Val Ala Phe 145 150 155 160

Page 2899

Thr Val Ser Leu Pro 165 Tyr Cys 069269_0225_SL.TXT Gly Pro Ser Glu Val Asp 170 Ser Phe 175 Phe Cys Asp Leu Pro Leu Val Ile Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Leu Gly Ile Leu Met Ile Ser Asp Ser Gly Val Ala Leu Tyr Glu Leu 195 200 205 Phe Cys Ala Pro Leu Gly Leu Leu His Cys Cys His His His Cys Pro 210 215 220 Thr Thr Cys Cys Trp Trp Gly Ile Gln Ser Thr Leu Tyr Leu Leu Cys 225 230 235 240 Met Tyr His Gly Asn His Ala Leu Ser Ser Leu Gly Pro Ala Phe Ser 245 250 255 Phe Val Cys Gly Leu Ser Val Gly Ser Leu Trp Thr Ser Phe Cys Leu 260 265 270 Cys Phe Tyr Thr Ile Phe Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr 275 280 285 Leu Arg Asn Lys Glu Met Lys Thr Ala Met Lys Lys Leu 290 295 300

<210> 2611 <211> 942 <212> DNA <213> Felis catus <400> 2611 ttatgtctcc tactttttcc aagtaagtcc actcctgtcc cacagtttct gcatggctga cttgacctct ttgttccgaa gtgtatagat gaggggattc atcatggggg taataacatt gtagagtaca gacaccatct tgtccacaga aaaagtggag aagggacggg catagatgaa aatacagggt ccaaagaaga gtgttaccac catgaggtgg gagccacagg tggagagtgc ctttcgcctt ccctccttgg agcgaatctt gaccaggata gtggagtagg aagaaaccag

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taccacaaag gagctggtag agatcaaccc actgttagat accattagca attcaatgac 360 aaaggtgtct gtacaggcaa gtttaatgac agggggaaca tcacaaaaga agttgtccac 420 atggtttggt ccacaaaagg gcagacggat agtgagaatc gtctggacag tagagtgcac 480 aaatcctccc atccaggagg cagctaccaa cacacagcat aatcctcgac tcatgatagt 540 ggtataatgc agggggcgac aaattgcaac atagcgatca taggccatca ctgtgagcag 600 gaacatctca gctgccccta caaaatgcag aaaaaagagc tgtgcaatgc attggtcata 660 gtgaatgagc ttgtcattat caagaaagtc agccagaagc ttcggagtag ttactgttga 720 ataacataag tccaggaaag agaggttgcc aagaaggaaa tacataggtg atgaattcaa 780 atagttatca gaggccactg tgaccatgat gaggacattg cctacccaag tggacacata 840 gaagaaaaga aatagtacaa atagtcctgc ctcagtagat ggtgtctgcg agaagcctgc 900 caggacaaag tctgtcacca ccgctgtttg attttcatcc at 942

<210> 2612 <211> 310 <212> PRT <213> Felis catus <400> 2612

Met Asp Glu Asn Gln Thr Ala Val Val Thr Asp Phe Val Leu Ala Gly 1 5 10 15 Phe Ser Gln Thr Pro Ser Thr Glu Ala Gly Leu Phe Val Leu Phe Leu 20 25 30 Phe Phe Tyr Val Ser Thr Trp Val Gly Asn Val Leu Ile Met Val Thr 35 40 45 Val Ala Ser Asp Asn Tyr Leu Asn Ser Ser Pro Met Tyr Phe Leu Leu 50 55 60 Gly Asn Leu Ser Phe Leu Asp Leu Cys Tyr Ser Thr Val Thr Thr Pro 65 70 75 80 Lys Leu Leu Ala Asp Phe Leu Asp Asn Asp Lys Leu Ile His Tyr Asp 85 90 95

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Gln Cys Ile Ala 100 Gln Leu Phe Phe Leu His Phe Val Gly Ala Ala Glu 105 110 Met Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Arg Pro Leu His Tyr Thr Thr Ile Met Ser Arg Gly Leu Cys Cys Val 130 135 140 Leu Val Ala Ala Ser Trp Met Gly Gly Phe Val His Ser Thr Val Gln 145 150 155 160 Thr Ile Leu Thr Ile Arg Leu Pro Phe Cys Gly Pro Asn His Val Asp 165 170 175 Asn Phe Phe Cys Asp Val Pro Pro Val Ile Lys Leu Ala Cys Thr Asp 180 185 190 Thr Phe Val Ile Glu Leu Leu Met Val Ser Asn Ser Gly Leu Ile Ser 195 200 205 Thr Ser Ser Phe Val Val Leu Val Ser Ser Tyr Ser Thr Ile Leu Val 210 215 220 Lys Ile Arg Ser Lys Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly 225 230 235 240 Ser His Leu Met Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe Ile 245 250 255 Tyr Ala Arg Pro Phe Ser Thr Phe Ser Val Asp Lys Met Val Ser Val 260 265 270 Leu Tyr Asn Val Ile Thr Pro Met Met Asn Pro Leu Ile Tyr Thr Leu 275 280 285 Arg Asn Lys Glu Val Lys Ser Ala Met Gln Lys Leu Trp Asp Arg Ser 290 295 300

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Gly Leu Thr Trp Lys Lys 305 310 <210> 2613 <211> 1009 <212> DNA <213> Felis catus <400> 2613

tgtaatttgg aaatctgtta tttttgcagc attacaaaca aatgaatatt ccaacataaa 60 taattgctct agctctgtga gtaaattcat ccttttaggc ttttcttata cctgggaaat 120 tcagattttc ctcttttcag tcttctctgg gacatatatt ctgacactaa ctggaaatct 180 ttgtattatc tgtgctgtga tgtgggacca tcaactacaa actccaatgt acatcctgct 240 ggccaatttt tccttcctgg agatctggtt tatcacctcc actgtcccta atatgctagc 300 caactttctc tctgagacca acaccatttc tgtctctgga tgcttcctcc agttctactt 360 cttcttctcc ctgggcacca ctgagacctt cttcttgtct gccatggcct ttgacaggta 420 ccttgctatc tgcaggcccc tgcattaccc cactgtcatg acagttcaac gctgcatcag 480 aacaggagct gggtgttggg tgtgtggctt cctgtacttc cccttgccta tttacctcat 540 ctctcagctt ccattttgtt gtcccaatac aattgatcat ttcctgtgtg acccaggacc 600 tcttataaag ctgtcctgtg tgccagctcc tgccactgag atcatctgtg ctatctataa 660 ctcagtcctc attttcacca ccttagtctt cattatcagc tcctatacct tggtgatcag 720 agctgtgctg aaggtcccct cagcagaagg tcggcataag gctttctcca catgtggctc 780 ccatttggct gtggtgtccc tgttctatgg ctctatcatg gttgtatatg tgagcccaac 840 agcaggcaat ccagcaggga ttcagaaata tgtgactttg tcctattctg tgttaactcc 900 actcttcaac cccttgatct atagtcttcg aaataaagag atgaaggtgg ctctgagaaa 960 gttatttaga atggtgagat ttagtcgtag gcatggaaga aatctttga 1009

<210> 2614 <211> 335 <212> PRT <213> Felis catus <400> 2614

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Val 1 Ile Trp Lys Ser 5 Val Ile Phe Ala Ala Leu Gln Thr Asn Glu Tyr 10 15 Ser Asn Ile Asn Asn Cys Ser Ser Ser Val Ser Lys Phe Ile Leu Leu 20 25 30 Gly Phe Ser Tyr Thr Trp Glu Ile Gln Ile Phe Leu Phe Ser Val Phe 35 40 45 Ser Gly Thr Tyr Ile Leu Thr Leu Thr Gly Asn Leu Cys Ile Ile Cys 50 55 60 Ala Val Met Trp Asp His Gln Leu Gln Thr Pro Met Tyr Ile Leu Leu 65 70 75 80 Ala Asn Phe Ser Phe Leu Glu Ile Trp Phe Ile Thr Ser Thr Val Pro 85 90 95 Asn Met Leu Ala Asn Phe Leu Ser Glu Thr Asn Thr Ile Ser Val Ser 100 105 110 Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr Glu 115 120 125 Thr Phe Phe Leu Ser Ala Met Ala Phe Asp Arg Tyr Leu Ala Ile Cys 130 135 140 Arg Pro Leu His Tyr Pro Thr Val Met Thr Val Gln Arg Cys Ile Arg 145 150 155 160 Thr Gly Ala Gly Cys Trp Val Cys Gly Phe Leu Tyr Phe Pro Leu Pro 165 170 175 Ile Tyr Leu Ile Ser Gln Leu Pro Phe Cys Cys Pro Asn Thr Ile Asp 180 185 190 His Phe Leu Cys Asp Pro Gly Pro Leu Ile Lys Leu Ser Cys Val Pro 195 200 205

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Ala Pro Ala Thr Glu Ile Ile Cys Ala Ile Tyr Asn Ser Val Leu Ile 210 215 220 Phe Thr Thr Leu Val Phe Ile Ile Ser Ser Tyr Thr Leu Val Ile Arg 225 230 235 240 Ala Val Leu Lys Val Pro Ser Ala Glu Gly Arg His Lys Ala Phe Ser 245 250 255 Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Ser Ile 260 265 270 Met Val Val Tyr Val Ser Pro Thr Ala Gly Asn Pro Ala Gly Ile Gln 275 280 285 Lys Tyr Val Thr Leu Ser Tyr Ser Val Leu Thr Pro Leu Phe Asn Pro 290 295 300 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Met Lys Val Ala Leu Arg Lys 305 310 315 320 Leu Phe Arg Met Val Arg Phe Ser Arg Arg His Gly Arg Asn Leu 325 330 335

<210> 2615 <211> 850 <212> DNA <213> Felis catus <400> 2615

caatactaaa aggccatttc tcatatggaa atttgttatt tttgcagcat tacagacaaa 60 tgaatattcc aacataagta attgctctag ttctaggagt aaattcattc tttgggtttc 120 ccttatacct gggaaattca gaggaaagag aaaaatcctt tcagtcttct ctggaatata 180 tttgttgaca ctaactggaa atccgttatc tgtgctgtga tgtgggacca tcaactacaa 240 actccaatgt acatcctgct ggccaatttt tccttcctgg agatctggtt tatcacctcc 300 actgtcccta atatgctagc caactttctc tctgaggcca acaccatttc ggtctctggc 360 tgcttcctcc aatcctactt cttcttctcc ctgggcacca ctgagacctt cttcttgtct 420

Page 2905

069269_0225_SL.TXT gccatggcct ttgaccagta ccttgctatc ttcaggcccc tgcattaccc cactgtcatg tcagttcagc actgcatcag aacaggagct gggtgctggg tatgtggctt cctgtatttc ctgttgccta tttacctgat ctctcagctc ccattttgtt gttccagtaa gattgatcac ttcctgtgtg acctagacat cctcataaat ctgtcccgta tgccatttcc tgccactgag atcatctgtg ccatctttaa ctcagtcttc attttcccca cctttctttt tattgccagc tcctacgtcc tggtgagtag aactgtgctc agggtccctt ctccacgtgt ggctcccatc tggctgtggt atccctgttt tatggctcta tcatggttgt atatgtaagt ccaacagcag acaatctagc <210> 2616 <211> 77 <212> PRT <213> Felis catus

<400> 2616 Met Val Pro His 1 His 5 Ser Thr Asp Asn Gly Phe Pro Val Ser Val Asn 10 15 Lys Tyr Ile Pro Glu Lys Thr Glu Arg Ile Phe Leu Phe Pro Leu Asn 20 25 30 Phe Pro Gly Ile Arg Glu Thr Gln Arg Met Asn Leu Leu Leu Glu Leu 35 40 45 Glu Gln Leu Leu Met Leu Glu Tyr Ser Phe Val Cys Asn Ala Ala Lys 50 55 60 Ile Thr Asn Phe His Met Arg Asn Gly Leu Leu Val Leu 65 70 75

<210> 2617 <211> 975 <212> DNA <213> Felis catus <400> 2617 ttactttgtt tccagaaaaa gaacatttct tatggctgca gaaacctggc cagacttcag ataccgactc ttcagtttta acatggctgc cttcacttct ttgttcctta gagtgtagat

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aattgggttt aaaataggag taaagattgt gtagaacaca gcaaggactt tgtcgacaga 180 ataactgctg aagggccaca catagatgaa gatgcatggt ccaaagaata gggtgaccac 240 agtgatatgg gcagtcaacg tggaacgggc ctttgccatg ctagcagagg agcgtttcct 300 gactgtgata agtatcacag tgtaggagac aaccaagagg agaaaggaac tcatagaaag 360 aaagccactg tctgcaacta taagtaggct gacaacataa gtgtcaatgc atgccagctt 420 ggtcactaaa gggaggtcac agaaaaaact atctacctga ttagggccac aaaaaggcaa 480 gttaattgta aatgccaact ggctagtagt atggataaaa cccacaagcc aggagatgag 540 aacaagaata atacacacac ggcgactcat gattgtcatg tagtggagag gtttgcatat 600 agcaacataa cggtcataag ccatggatac aaggagcacc atttcactgc cagtgaaaag 660 gtgaacaaag aaaatctggg ccaaacaggc atcaaaagaa atagtcttct gctcaaccag 720 aaagtctgca atcattttgg gtgtagcaaa agaggcaaca catatatcta caaaagagag 780 gtttgcaagc aggaagtaca tgggggtgtg aaggtgagaa tctgaggtta cagtgaggat 840 gataagaaag tttcccagca gtattgctag gtaaagtagt gaaaatatga caaacaagaa 900 aggttggagc tcctgggaat tagagagtcc cagcaacaca aactctgtca cccgggaatg 960 atttgtctca ttcat 975

<210> 2618 <211> 324 <212> PRT <213> Felis catus <400> 2618

Met 1 Asn Glu Thr Asn His Ser Arg Val Thr Glu Phe Val Leu Leu 15 Gly 5 10 Leu Ser Asn Ser Gln Glu Leu Gln Pro Phe Leu Phe Val Ile Phe Ser 20 25 30 Leu Leu Tyr Leu Ala Ile Leu Leu Gly Asn Phe Leu Ile Ile Leu Thr 35 40 45 Val Thr Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Ala

50 55 60

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Asn 65 Leu Ser Phe Val Asp Ile Cys Val Ala Ser Phe Ala Thr Pro Lys 70 75 80 Met Ile Ala Asp Phe Leu Val Glu Gln Lys Thr Ile Ser Phe Asp Ala 85 90 95 Cys Leu Ala Gln Ile Phe Phe Val His Leu Phe Thr Gly Ser Glu Met 100 105 110 Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Met Thr Ile Met Ser Arg Arg Val Cys Ile Ile Leu 130 135 140 Val Leu Ile Ser Trp Leu Val Gly Phe Ile His Thr Thr Ser Gln Leu 145 150 155 160 Ala Phe Thr Ile Asn Leu Pro Phe Cys Gly Pro Asn Gln Val Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Leu Val Thr Lys Leu Ala Cys Ile Asp Thr 180 185 190 Tyr Val Val Ser Leu Leu Ile Val Ala Asp Ser Gly Phe Leu Ser Met 195 200 205 Ser Ser Phe Leu Leu Leu Val Val Ser Tyr Thr Val Ile Leu Ile Thr 210 215 220 Val Arg Lys Arg Ser Ser Ala Ser Met Ala Lys Ala Arg Ser Thr Leu 225 230 235 240 Thr Ala His Ile Thr Val Val Thr Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Val Trp Pro Phe Ser Ser Tyr Ser Val Asp Lys Val Leu Ala 260 265 270

Page 2908

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Val Phe Tyr 275 Thr Ile Phe Thr Pro Ile Leu Asn Pro Ile Ile Tyr Thr 280 285 Leu Arg Asn Lys Glu Val Lys Ala Ala Met Leu Lys Leu Lys Ser Arg 290 295 300 Tyr Leu Lys Ser Gly Gln Val Ser Ala Ala Ile Arg Asn Val Leu Phe 305 310 315 320

Leu Glu Thr Lys <210> 2619 <211> 936 <212> DNA <213> Felis catus <400> 2619

ctagtttttc caggagttca catgacggtt tctcagcttt cgcatggctg atttaacatc 60 ttcattcctt agagagtaga ttatgggatt caacaggggc gtacaaacag tgtagaacac 120 agaaaggaac ttatccacag aaagtctgct aaaaggccat atatagaagt aaatgcaagg 180 cccaaagaaa agaatcacca ctgtgatgtg agcagttaat gtagaaagtg ccttggatga 240 cccactggag gaccggcgac gaacagtgat caaaatgatg gtgtaggaaa taattaaagc 300 cagaaaacag cccaatgata tcaggccact gttagttagg gtcataattt ccatttcata 360 agtatccata caagccagct ctatcactag gggaaggtca caaaagaagc tatcgacctc 420 attggggcca cagaatggca aatccactgt aaaagccaag tgactcacag aatgaagaat 480 acccacagcc caggaaataa atacgaaaat tatacatagt ctccgattca taattgtgct 540 ataatgtagg ggcttacaga tggctataaa tctgtcatat gccatagcta caagcaacat 600 catctcactc ccaacaaaac tgtgaagaag gaatatctgg gccatgcagc cctcaaagga 660 gatcgtctta tgctcaacaa agaagtccac aagcatcttg ggggtggcaa aattagattg 720 gcagatatca ataaaagaaa ggttactgag taggaagtac ataggagagt tcaaatgtga 780 gtcagaggaa attatgacaa taatcatgat gttgcccagc actgatgtca catacactaa 840

Page 2909

900

936

069269_0225_SL.TXT agagaagatg gcaaaaaaga aaagctgaag ttcccaagag ttagacagtc ccagaagcac aaactcagat accactgatt catttgtgtg agccat <210> 2620 <211> 311 <212> PRT <213> Felis catus <400> 2620

Met Ala His Thr Asn Glu Ser Val Val Ser Glu Phe Val Leu Leu Gly 1 5 10 15 Leu Ser Asn Ser Trp Glu Leu Gln Leu Phe Phe Phe Ala Ile Phe Ser 20 25 30 Leu Val Tyr Val Thr Ser Val Leu Gly Asn Ile Met Ile Ile Val Ile 35 40 45 Ile Ser Ser Asp Ser His Leu Asn Ser Pro Met Tyr Phe Leu Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Ile Cys Gln Ser Asn Phe Ala Thr Pro Lys 65 70 75 80 Met Leu Val Asp Phe Phe Val Glu His Lys Thr Ile Ser Phe Glu Gly 85 90 95 Cys Met Ala Gln Ile Phe Leu Leu His Ser Phe Val Gly Ser Glu Met 100 105 110 Met Leu Leu Val Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Ile Met Asn Arg Arg Leu Cys Ile Ile Phe 130 135 140 Val Phe Ile Ser Trp Ala Val Gly Ile Leu His Ser Val Ser His Leu 145 150 155 160 Ala Phe Thr Val Asp Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Ser

Page 2910

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165 170 175

Phe Phe Cys Asp Leu Pro Leu Val Ile Glu Leu Ala Cys Met Asp Thr 180 185 190 Tyr Glu Met Glu Ile Met Thr Leu Thr Asn Ser Gly Leu Ile Ser Leu 195 200 205 Gly Cys Phe Leu Ala Leu Ile Ile Ser Tyr Thr Ile Ile Leu Ile Thr 210 215 220 Val Arg Arg Arg Ser Ser Ser Gly Ser Ser Lys Ala Leu Ser Thr Leu 225 230 235 240 Thr Ala His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Cys Ile Tyr 245 250 255 Phe Tyr Ile Trp Pro Phe Ser Arg Leu Ser Val Asp Lys Phe Leu Ser 260 265 270 Val Phe Tyr Thr Val Cys Thr Pro Leu Leu Asn Pro Ile Ile Tyr Ser 275 280 285 Leu Arg Asn Glu Asp Val Lys Ser Ala Met Arg Lys Leu Arg Asn Arg 290 295 300 His Val Asn Ser Trp Lys Asn 305 310

<210> 2621 <211> 972 <212> DNA <213> Felis catus <400> 2621 ttaataaaga gaattcctca ctactagtgg catttcagaa attttcttgg gcctcaggta ataggtcata atcttcctca tggcagcctt catatccctg ttccttagtg tgtaaataat ggggtttaga atgggagtga aaatggtgta aaatatggct agaagtttat ccacagggta agtggtaaag ggccacacat agataaagat gcaaggtcca aagaacaata ttaccacggt Page 2911

120

180

240

069269_0225_SL.TXT tatatgggca gcccgtgttg aaaatgcctt ggtgacaaga ataatgatgt aagagacaac tccactattg actacaatta gtatttcaac cactcgagga aggtcacaaa aaaagctgtc tacagtaaat gataactggc ttaatgtgtg caggaaactg cacgtccttc tgctcatgat tacatatctg tcataggcca tggagacaag aatgaagaaa atctgggcta tgcagccact atctgcaatc atcttagggg tagcaaaaga tcccaggagg aagtacatgg gggagtgcag gagaaggttt cccagcacaa tgaccacata ttggagatcc tgagaactac agagtcccag gaccttatcc at <210> 2622 <211> 323 <212> PRT <213> Felis catus ggccattgca gcagaagact taaaccagac caagagagag aaagtactta gggaaagaat agtataagag tccaggcagg caagtttggt tacaacattg ggtccacaaa aaggcaggtt caccaagccc acagcccagg agaccattac gactacatag tgtaggggtt tgcatatagc tagtaccatc tctcctccag taaaaaggtg gaaggagatg gtcttgtgtt cactcagaaa agcctgacag atgtccacaa aggacaggtt gctgttatca gaggttactg tcatgatgat taacacagag aagaaaacaa aaaagaaaag caatacaaat tcagacacca ctgaagaatt

300

360

420

480

540

600

660

720

780

840

900

960

972

<400> 2622 Met Asp Lys Val Asn Ser Ser Val 1 5 Leu Cys Ser Ser Gln Asp Leu Gln 20 Val Leu Tyr Val Val Ile Val Leu 35 40 Val Thr Ser Asp Asn Ser Leu His 50 55 Asn Leu Ser Phe Val Asp Ile Cys 65 70

Val Ser 10 Glu Phe Val Leu Leu 15 Gly Leu 25 Phe Phe Phe Val Phe 30 Phe Ser Gly Asn Leu Leu Ile 45 Ile Met Thr Ser Pro Met Tyr 60 Phe Leu Leu Gly Gln Ala Ser 75 Phe Ala Thr Pro Lys 80

Page 2912

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Met Ile Ala Asp Phe 85 Leu Ser Glu His Lys Thr Ile Ser Phe Ser Gly 90 95 Cys Ile Ala Gln Ile Phe Phe Ile His Leu Phe Thr Gly Gly Glu Met 100 105 110 Val Leu Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Val Val Ile Met Ser Arg Arg Thr Cys Ser Phe Leu 130 135 140 Val Met Val Ser Trp Ala Val Gly Leu Val His Thr Leu Ser Gln Leu 145 150 155 160 Ser Phe Thr Val Asn Leu Pro Phe Cys Gly Pro Asn Val Val Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Arg Val Thr Lys Leu Ala Cys Leu Asp Ser 180 185 190 Tyr Thr Val Glu Ile Leu Ile Val Val Asn Ser Gly Ile Leu Ser Leu 195 200 205 Ser Thr Phe Ser Leu Leu Val Val Ser Tyr Ile Ile Ile Leu Val Thr 210 215 220 Val Trp Phe Lys Ser Ser Ala Ala Met Ala Lys Ala Phe Ser Thr Arg 225 230 235 240 Ala Ala His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Val Trp Pro Phe Thr Thr Tyr Pro Val Asp Lys Leu Leu Ala 260 265 270 Ile Phe Tyr Thr Ile Phe Thr Pro Ile Leu Asn Pro Ile Ile Tyr Thr 275 280 285

Page 2913

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Leu Arg Asn Arg Asp Met Lys Ala Ala Met Arg Lys Ile Met Thr Tyr 290 295 300 Tyr Leu Arg Pro Lys Lys Ile Ser Glu Met Pro Leu Val Val Arg Asn 305 310 315 320 Ser Leu Tyr

<210> 2623 <211> 950 <212> DNA <213> Felis catus <400> 2623

taaaaataat gccaaggagt tgtcttgtta ggatttagaa gcctattttt cagtttattc 60 atggctgtct tcacttcttg attccttaaa gtataaatta gtgggttcag aatgggagta 120 aagatggtat aaaacacaga caggatcttg tctgtaagaa aactgcttag tggccacata 180 tagatgaaga tgcatggccc aaagaacatg aatacaacaa tgaaatgagc tgtgcaggta 240 gaaagggcct tagatgatcc ttttgaagaa tgatgcttga tagtaacaaa gacaataaca 300 taagagttga ataaaagaat aaagcaggac aatgcaatta tgccacttgt tgagatcata 360 aacaggccca gaacataagt atctacacaa gctagctgga acaccacagg aaggtcacag 420 aaaaagctgt ctacttcatt gggaccacag aatggtaatg tgagagcaaa tatgacctgg 480 ctcattgaat gcatgactcc cacaacccag gaagccacca caagggcagc acacacccag 540 ggtcttatga ctgaagtgta gtggagaggc ttgcatattg caatatacct atcaagggac 600 atggccataa gtaaaattat ctcagtacca gtaaaaaggt gtaggaaaaa tatctgggtg 660 atacaaccat caaaggagat ggttttgtgt ccagtgaggt agtctgcaat catcttaggg 720 gtggcaaagg aagcaaggga catatcaatg atggaaaggt tggtaagtag aaaatacata 780 ggagagtgta ggtgagagtc agccataacc gtgatgacta tgagactgtt accaaccatt 840 gttgccacat aaaacaatga aaacactatg aagaaaaaca gctgtagttc ccaggaatta 900 gagagtccaa gcaaaacaaa ttcagaaaca gacttattgg ccacatccat 950

Page 2914

069269_0225_SL.TXT <210> 2624 <211> 317 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (317)..(317) <223> Any amino acid

<400> 2624 Lys Ser Val Ser Glu Phe Val Leu Leu Gly Leu Met Asp 1 Val Ala Asn 5 10 15 Ser Asn Ser Trp Glu Leu Gln Leu Phe Phe Phe Ile Val Phe Ser Leu 20 25 30 Phe Tyr Val Ala Thr Met Val Gly Asn Ser Leu Ile Val Ile Thr Val 35 40 45 Met Ala Asp Ser His Leu His Ser Pro Met Tyr Phe Leu Leu Thr Asn 50 55 60 Leu Ser Ile Ile Asp Met Ser Leu Ala Ser Phe Ala Thr Pro Lys Met 65 70 75 80 Ile Ala Asp Tyr Leu Thr Gly His Lys Thr Ile Ser Phe Asp Gly Cys 85 90 95 Ile Thr Gln Ile Phe Phe Leu His Leu Phe Thr Gly Thr Glu Ile Ile 100 105 110 Leu Leu Met Ala Met Ser Leu Asp Arg Tyr Ile Ala Ile Cys Lys Pro 115 120 125 Leu His Tyr Thr Ser Val Ile Arg Pro Trp Val Cys Ala Ala Leu Val 130 135 140 Val Ala Ser Trp Val Val Gly Val Met His Ser Met Ser Gln Val Ile 145 150 155 160

Page 2915

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Phe Ala Leu Thr Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Ser Phe 165 170 175 Phe Cys Asp Leu Pro Val Val Phe Gln Leu Ala Cys Val Asp Thr Tyr 180 185 190 Val Leu Gly Leu Phe Met Ile Ser Thr Ser Gly Ile Ile Ala Leu Ser 195 200 205 Cys Phe Ile Leu Leu Phe Asn Ser Tyr Val Ile Val Phe Val Thr Ile 210 215 220 Lys His His Ser Ser Lys Gly Ser Ser Lys Ala Leu Ser Thr Cys Thr 225 230 235 240 Ala His Phe Ile Val Val Phe Met Phe Phe Gly Pro Cys Ile Phe Ile 245 250 255 Tyr Met Trp Pro Leu Ser Ser Phe Leu Thr Asp Lys Ile Leu Ser Val 260 265 270 Phe Tyr Thr Ile Phe Thr Pro Ile Leu Asn Pro Leu Ile Tyr Thr Leu 275 280 285 Arg Asn Gln Glu Val Lys Thr Ala Met Asn Lys Leu Lys Asn Arg Leu 290 295 300 Leu Asn Pro Asn Lys Thr Thr Pro Trp His Tyr Phe Xaa 305 310 315 <210> 2625 <211> 960 <212> DNA <213> Felis catus <400> 2625 tcattgcact ggatatcttg gagaagtttt cccaagattt aggtattggt tacttagttt cttcttcaca gccgtcttca tttcctggtt tctcaaagta tagatgagtg gattcagaaa gggggtaaag atggtataga aaacagacag aactttgtcc accaggaagt tggtgaaagg

120

180

Page 2916

069269_0225_SL.TXT

ccacacatag atgaagatgc agggcccaaa gaacattaac acaactagga aatgtgcagt 240 acaggtagaa aaaaccttag atgatcctgt ggaagagtgg tccttgatag tgacaagaac 300 aatgacgtag gaggtgagca aaagcagaaa acttacaaga gcaatcacac cactagttga 360 gatcatgaag attccaagaa catagatatc tatacaagcc agctggatga ccaaaggaag 420 gtcacagaag aaactgtcta caacattggg accacagaag ggtaaacaga gagtaaaagc 480 taactggctc attgtatgca ggaagcccac tgtccaagaa gttaccacaa gcccaacaca 540 cactctttgg ctcataattg ttgaataatg gagaggtttg catatggcaa tgtacctgtc 600 aaaagacatg gagatcagca gcacaatctc agtcccagtg aaaaggtgca aaaaaaagat 660 ctgagaaatg cagccctcaa aggagatggt cttatgctca gcaaagaagt ccatgatcat 720 ctttggagtg gcaaaggagg acaagcacat gtcaatgaga gacaggttgc tgaggaggaa 780 atacatgggg gagtgaaggt gtggggtgca taggactgtg agcaaaatca agcagttgcc 840 caacatagtt agtaaataga aaacagaaaa catcacaaag aaaaaaatct ggagctcagg 900 agaatcagta agtccaagta atacaaattc agatactcca gaatggttga atccctccat 960

<210> 2626 <211> 319 <212> PRT <213> Felis catus

<400> 2626 Met Glu Gly Phe 1 Asn His Ser Gly Val Ser Glu Phe Val Leu Leu 15 Gly 5 10 Leu Thr Asp Ser Pro Glu Leu Gln Ile Phe Phe Phe Val Met Phe Ser 20 25 30 Val Phe Tyr Leu Leu Thr Met Leu Gly Asn Cys Leu Ile Leu Leu Thr 35 40 45 Val Leu Cys Thr Pro His Leu His Ser Pro Met Tyr Phe Leu Leu Ser 50 55 60 Asn Leu Ser Leu Ile Asp Met Cys Leu Ser Ser Phe Ala Thr Pro Lys 65 70 75 80

Page 2917

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Met Ile Met Asp Phe 85 Phe Ala Glu His Lys Thr Ile Ser Phe Glu Gly 90 95 Cys Ile Ser Gln Ile Phe Phe Leu His Leu Phe Thr Gly Thr Glu Ile 100 105 110 Val Leu Leu Ile Ser Met Ser Phe Asp Arg Tyr Ile Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Ile Met Ser Gln Arg Val Cys Val Gly Leu 130 135 140 Val Val Thr Ser Trp Thr Val Gly Phe Leu His Thr Met Ser Gln Leu 145 150 155 160 Ala Phe Thr Leu Cys Leu Pro Phe Cys Gly Pro Asn Val Val Asp Ser 165 170 175 Phe Phe Cys Asp Leu Pro Leu Val Ile Gln Leu Ala Cys Ile Asp Ile 180 185 190 Tyr Val Leu Gly Ile Phe Met Ile Ser Thr Ser Gly Val Ile Ala Leu 195 200 205 Val Ser Phe Leu Leu Leu Leu Thr Ser Tyr Val Ile Val Leu Val Thr 210 215 220 Ile Lys Asp His Ser Ser Thr Gly Ser Ser Lys Val Phe Ser Thr Cys 225 230 235 240 Thr Ala His Phe Leu Val Val Leu Met Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Val Trp Pro Phe Thr Asn Phe Leu Val Asp Lys Val Leu Ser 260 265 270 Val Phe Tyr Thr Ile Phe Thr Pro Phe Leu Asn Pro Leu Ile Tyr Thr 275 280 285

Page 2918

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Leu Arg Asn Gln Glu Met Lys Thr Ala Val Lys Lys Lys Leu Ser Asn 290 295 300 Gln Tyr Leu Asn Leu Gly Lys Thr Ser Pro Arg Tyr Pro Val Gln

305 310 315 <210> 2627 <211> 924 <212> DNA <213> Felis catus <400> 2627

ttaggctatg tgctgattaa acagcctcct catggaagct tttacttcct ggttgcgaag 60 tgtataaatc acaggattca gcaaaggaaa gatcactgtg tgaaagagag aaaccacctt 120 gtcagctggg aaggctctga aggggcgagt gtagataaag ataccaggcc caaacataag 180 aaatataacg atgatatggg tggtgcatgt ggatacggcc ttgctcttcc cctcagagga 240 agatccatgt acacgacaga ggatgactgc ataggaggcc agaagcccca ggaagcacag 300 gagggtcatc aggccactgt tgaagaccat tagaagctcc accacgaagg tgtctgtgca 360 ggccagcttg atgacctgtg gcacatcaca gaagaagtta tccagttggt ttgggccaca 420 gaagggcaag tggaggatga gggccacctg gataatggag tggacaaagc ctccaagcca 480 cagggccaac agcaaggcat agcaggctct agggttcatg actgtggaat agtgtaaagg 540 ccgacagatg gcgatatagc ggtcaaaggc catcacaaca aggagtaacc cttcccctcc 600 tccaaggaag tgcaagaaaa agagctgagt gatgcagccc ctgtaggaga ttaccttctt 660 ctcagagagg aagtccacca gcatcctggg agccacaatg aaggagtagg atgcatccag 720 gaaagccaag ttgcccagaa agaagtagag gggggctgtg agaccagggt ctgatctgat 780 ggtgaggatg atgaggaaat ttccaggaag gatgatgaga tagaaaatta aaactaggac 840 aaagaccaga agctgaatat ctcgagactg ggtgagacca agaaggatga attctttcac 900 caccgtgctg ttgtcatttt ccat 924

<210> 2628 <211> 307 <212> PRT

Page 2919

069269_0225_SL.TXT <213> Felis catus <400> 2628

Met Glu Asn Asp Asn Ser Thr Val Val Lys Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Thr Gln Ser Arg Asp Ile Gln Leu Leu Val Phe Val Leu Val Leu 20 25 30 Ile Phe Tyr Leu Ile Ile Leu Pro Gly Asn Phe Leu Ile Ile Leu Thr 35 40 45 Ile Arg Ser Asp Pro Gly Leu Thr Ala Pro Leu Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ala Phe Leu Asp Ala Ser Tyr Ser Phe Ile Val Ala Pro Arg 65 70 75 80 Met Leu Val Asp Phe Leu Ser Glu Lys Lys Val Ile Ser Tyr Arg Gly 85 90 95 Cys Ile Thr Gln Leu Phe Phe Leu His Phe Leu Gly Gly Gly Glu Gly 100 105 110 Leu Leu Leu Val Val Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Ser Thr Val Met Asn Pro Arg Ala Cys Tyr Ala Leu 130 135 140 Leu Leu Ala Leu Trp Leu Gly Gly Phe Val His Ser Ile Ile Gln Val 145 150 155 160 Ala Leu Ile Leu His Leu Pro Phe Cys Gly Pro Asn Gln Leu Asp Asn 165 170 175 Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Val Val Glu Leu Leu Met Val Phe Asn Ser Gly Leu Met Thr Leu

Page 2920

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195 200 205 Leu Cys Phe Leu Gly Leu Leu Ala Ser Tyr Ala Val Ile Leu Cys Arg 210 215 220 Val His Gly Ser Ser Ser Glu Gly Lys Ser Lys Ala Val Ser Thr Cys 225 230 235 240 Thr Thr His Ile Ile Val Ile Phe Leu Met Phe Gly Pro Gly Ile Phe 245 250 255 Ile Tyr Thr Arg Pro Phe Arg Ala Phe Pro Ala Asp Lys Val Val Ser 260 265 270 Leu Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Val Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Val Lys Ala Ser Met Arg Arg Leu Phe Asn Gln 290 295 300 His Ile Ala

305

<210> 2629 <211> 945 <212> DNA <213> Felis catus <400> 2629 ctttcacttc tctttacata aaatatatct gttgaccaac ttcctcatgg ctgtctttac 60 ttccttattt cgcaaggtat agataatggg attaagtaaa gggaatatca cagtatggaa 120 cactgacacc actttatcta gggaaaaaga gtcaaatggg cgagcataaa tgtagatgga 180 tggcccaaac ataaatacca caatggtgat gtgggaatag caggtggaca tggcccggct 240 ggtactctca tctgagcctg aatgtttctt aagcatggcc aggaggaagg cgtaggacat 300 taagagagca atgaaacata ccacagagat cagaccactg ctaaaaatca tcactaattc 360 ctccgggaag gtattggcac aggcaatccg gataacctgc gtgatgtcac agaagtaact 420 gtctaactca ttgggcccac agaacggaag tcgaacaatg agagccactt gtattataga 480

Page 2921

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atgaataaag ccccccaacc aggagagaac caccaggata ctgcagagac gtcgattcat 540 gatagtagca tagtggagag gacggcagat agcagcatag cggtcaaacg ccattactgt 600 gagcaggaac atctctgagg ctccaacaaa gtgcaagaaa aagagctgtg caatgcaccc 660 accaaaggaa attctcttcc tttccacaaa gaagtctatg agcattttag gggctgtgat 720 ggaggagtac caaatgtcaa ggaaggccag attagccaac aggaaataca tgggtgaggt 780 caaatgaggg tcaagcctga ttgtgcaaat aataagaata tttcctggaa ggatgaacaa 840 atagaaggat agaaatataa caaataggac tagttgtacc tctcgagtct gggataggcc 900 agtgagaaca aactctgtca ctcttgtgta atttgcaggt tccat 945

<210> 2630 <211> 313 <212> PRT <213> Felis catus <400> 2630

Met Glu Pro Ala Asn Tyr Thr Arg Val Thr Glu Phe Val Leu Thr Gly 1 5 10 15 Leu Ser Gln Thr Arg Glu Val Gln Leu Val Leu Phe Val Ile Phe Leu 20 25 30 Ser Phe Tyr Leu Phe Ile Leu Pro Gly Asn Ile Leu Ile Ile Cys Thr 35 40 45 Ile Arg Leu Asp Pro His Leu Thr Ser Pro Met Tyr Phe Leu Leu Ala 50 55 60 Asn Leu Ala Phe Leu Asp Ile Trp Tyr Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Met Leu Ile Asp Phe Phe Val Glu Arg Lys Arg Ile Ser Phe Gly Gly 85 90 95 Cys Ile Ala Gln Leu Phe Phe Leu His Phe Val Gly Ala Ser Glu Met 100 105 110

Page 2922

Phe Leu Leu 115 Thr Val Met Ala 069269_0225_SL.TXT Phe Asp Arg Tyr Ala Ala 120 125 Ile Cys Arg Pro Leu His Tyr Ala Thr Ile Met Asn Arg Arg Leu Cys Ser Ile Leu 130 135 140 Val Val Leu Ser Trp Leu Gly Gly Phe Ile His Ser Ile Ile Gln Val 145 150 155 160 Ala Leu Ile Val Arg Leu Pro Phe Cys Gly Pro Asn Glu Leu Asp Ser 165 170 175 Tyr Phe Cys Asp Ile Thr Gln Val Ile Arg Ile Ala Cys Ala Asn Thr 180 185 190 Phe Pro Glu Glu Leu Val Met Ile Phe Ser Ser Gly Leu Ile Ser Val 195 200 205 Val Cys Phe Ile Ala Leu Leu Met Ser Tyr Ala Phe Leu Leu Ala Met 210 215 220 Leu Lys Lys His Ser Gly Ser Asp Glu Ser Thr Ser Arg Ala Met Ser 225 230 235 240 Thr Cys Tyr Ser His Ile Thr Ile Val Val Phe Met Phe Gly Pro Ser 245 250 255 Ile Tyr Ile Tyr Ala Arg Pro Phe Asp Ser Phe Ser Leu Asp Lys Val 260 265 270 Val Ser Val Phe His Thr Val Ile Phe Pro Leu Leu Asn Pro Ile Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Glu Val Lys Thr Ala Met Arg Lys Leu Val 290 295 300 Asn Arg Tyr Ile Leu Cys Lys Glu Lys

305 310

Page 2923

069269_0225_SL.TXT <210> 2631 <211> 927 <212> DNA <213> Felis catus <400> 2631

cttttccttc aaggagaact tgcgactcca tatccgtttc atggcattct ttacatcctc 60 attcctcaga gtatagatga gtgggtttag cattggggta atggtagtat aaaacacaga 120 cacagcctta tccagtggga aagtagtgga gggacggaga taaataaata tacaagggac 180 aaagaagaaa gttactacag tgaaatgaga cccacaggta gagagagcct tgcgccggct 240 ctctgaagat cgcttacgga gactaaacag aatgaccgtg taggaggcca gaagaatgag 300 gaaacacccc agagagatga gaccactgtt ggcaaccacc aacatattta ccagggttgt 360 atcagcacag gcaagcttta ggactgggtg gacatcacaa aagtagtggt caatgacctg 420 atcattgcag aaaggcagct gaaaggtcag aagggtctga acaaaggaat gacccagggc 480 tcctaaccag gacaatgatg ccagaacaat acaaacattg gcactcatga tggtagtata 540 acggagaggt tggcagatgg cagcataacg gtcgaaagcc ataacagtca aaacaaaaat 600 ctccgcacac ccaaaaaagt ggaaggtaaa catctgagtt acacagcccc agtaggaaat 660 ggtctttttc tcagaaataa agtctgcaat catcttgggt gctgtggctg aggaataggc 720 aatgtccaca aaggacaggt tactgaggaa gaaatacatg ggcgtttgga gctggggatc 780 agaaaagacc gtaagcaaaa tgagcagatt tcccaccatg atcacgatgt agaagaggag 840 aaataaggca aagaacatca gttgcattcc aggatcttgg gaaagtccta ggaatataaa 900 ttcagtgaca ttattagcca cttccat 927

<210> 2632 <211> 309 <212> PRT <213> Felis catus <400> 2632

Met Glu Val Ala Asn Asn Val Thr Glu Phe Ile Phe Leu Gly Leu Ser 1 5 10 15

Gln Asp Pro Gly Met Gln Leu Met Phe Phe Ala Leu Phe Leu Leu Phe 20 25 30

Page 2924

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Tyr Ile Val 35 Ile Met Val Gly Asn Leu Leu Ile Leu Leu Thr Val Phe 40 45 Ser Asp Pro Gln Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Phe Val Asp Ile Ala Tyr Ser Ser Ala Thr Ala Pro Lys Met Ile 65 70 75 80 Ala Asp Phe Ile Ser Glu Lys Lys Thr Ile Ser Tyr Trp Gly Cys Val 85 90 95 Thr Gln Met Phe Thr Phe His Phe Phe Gly Cys Ala Glu Ile Phe Val 100 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Gln Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Ser Ala Asn Val Cys Ile Val Leu Ala Ser 130 135 140 Leu Ser Trp Leu Gly Ala Leu Gly His Ser Phe Val Gln Thr Leu Leu 145 150 155 160 Thr Phe Gln Leu Pro Phe Cys Asn Asp Gln Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Val His Pro Val Leu Lys Leu Ala Cys Ala Asp Thr Thr Leu 180 185 190 Val Asn Met Leu Val Val Ala Asn Ser Gly Leu Ile Ser Leu Gly Cys 195 200 205 Phe Leu Ile Leu Leu Ala Ser Tyr Thr Val Ile Leu Phe Ser Leu Arg 210 215 220 Lys Arg Ser Ser Glu Ser Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240

Page 2925

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His Phe Thr Val Val Thr Phe Phe Phe Val Pro Cys Ile Phe Ile Tyr 245 250 255 Leu Arg Pro Ser Thr Thr Phe Pro Leu Asp Lys Ala Val Ser Val Phe 260 265 270 Tyr Thr Thr Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Glu Asp Val Lys Asn Ala Met Lys Arg Ile Trp Ser Arg Lys Phe 290 295 300 Ser Leu Lys Glu Lys

305 <210> 2633 <211> 948 <212> DNA <213> Felis catus <400> 2633 tcatccttta acatggcaga aggatgccac atgctttttt ctcagcttct tcatgacagt cttcatttca gcatttctga gtgtgtagat gagaggattc aacataggtg tgatcactgt gtaaaagaca gagaatacct tatccacgga gaagctgcag aaaggcctca ggtagatgaa tacacatggc acaaagatca ggctgaccac tgttaggtgg gaggcacagg tagagagtgc cttgctgtgg ccctgacgga agcgagttct cacagtgatg aggatgatgg cataagagaa cagcaagacc aaaaagcaga cgagagataa cagaccacta tttgagacca tcagcacctc tactacatat gtgtctgtgc acgctagctt gatgacctgt gggacatcac agtagaagtt gtccagttca gtgggaccac agaagggcag ctgtatgacc agcgtgacct gtgtgataga atggatgaaa cccccacacc aacaggcaaa aaccaactga aagcagagct gacgattcat gactgtcaag tagtgcaaag gattacatat ggcaacatac ctatcatagg ccatgactgt cagcagaaac atctcactgg ctcccagaaa gtgcaggaag tagatctggg ccaagcatcc tgaaaaagag atgatcttgt cttgctgtag gaaatctcct aacatcttgg gcacagtaac acagctcagg cataggtcaa tgaaggacag atggcccaaa aaatagtaca taggagattg

120

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300

360

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480

540

600

660

720

780

Page 2926

069269_0225_SL.TXT gagcaggtga gcatcagctc gcactgttac aattatcaag aggtttccca aaacaacagt catgtaaaaa aacaaaaata ttaagaagag aaatagctgt agctcccaag aggatgatag gcccagaaga acaaattctg tcactttaga atcatttctt tttttcat

840

900

948 <210> 2634 <211> 315 <212> PRT <213> Felis catus

<400> 2634 Met 1 Lys Lys Arg Asn Asp 5 Ser Lys Val Thr 10 Glu Phe Val Leu Leu 15 Gly Leu Ser Ser Ser Trp Glu Leu Gln Leu Phe Leu Phe Leu Ile Phe Leu 20 25 30 Phe Phe Tyr Met Thr Val Val Leu Gly Asn Leu Leu Ile Ile Val Thr 35 40 45 Val Arg Ala Asp Ala His Leu Leu Gln Ser Pro Met Tyr Tyr Phe Leu 50 55 60 Gly His Leu Ser Phe Ile Asp Leu Cys Leu Ser Cys Val Thr Val Pro 65 70 75 80 Lys Met Leu Gly Asp Phe Leu Gln Gln Asp Lys Ile Ile Ser Phe Ser 85 90 95 Gly Cys Leu Ala Gln Ile Tyr Phe Leu His Phe Leu Gly Ala Ser Glu 100 105 110 Met Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu His Tyr Leu Thr Val Met Asn Arg Gln Leu Cys Phe Gln 130 135 140 Leu Val Phe Ala Cys Trp Cys Gly Gly Phe Ile His Ser Ile Thr Gln 145 150 155 160

Page 2927

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Val Thr Leu Val Ile Gln Leu Pro Phe Cys Gly Pro Thr Glu Leu Asp 165 170 175 Asn Phe Tyr Cys Asp Val Pro Gln Val Ile Lys Leu Ala Cys Thr Asp 180 185 190 Thr Tyr Val Val Glu Val Leu Met Val Ser Asn Ser Gly Leu Leu Ser 195 200 205 Leu Val Cys Phe Leu Val Leu Leu Phe Ser Tyr Ala Ile Ile Leu Ile 210 215 220 Thr Val Arg Thr Arg Phe Arg Gln Gly His Ser Lys Ala Leu Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ser Leu Ile Phe Val Pro Cys Val 245 250 255 Phe Ile Tyr Leu Arg Pro Phe Cys Ser Phe Ser Val Asp Lys Val Phe 260 265 270 Ser Val Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Thr Leu Arg Asn Ala Glu Met Lys Thr Val Met Lys Lys Leu Arg Lys 290 295 300 Lys His Val Ala Ser Phe Cys His Val Lys Gly 305 310 315

<210> 2635 <211> 977 <212> DNA <213> Felis catus <400> 2635 tgactcaatg aatgtctctg agccatattc cagctttgct tctgtaagag aatttatact cttaggtttt tcctgtgagt ggaaaattca gatcctccta ttttcactct ttactacaat

120

Page 2928

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gtatgctttg actgtaacag ggaacggggc cattgtctgt gctctgtggt gtgaatggaa 180 actccacatc cccatgtaca gattcctggg gaatttctcc tttctagaga tctggtatgt 240 ctcttctaca gtccccaaga tgttgatcaa cttcctctca gataaaaaga ccatctcatt 300 tgctggatgt ttcctccaat tttatttctt tttctctttg ggaacatctg aatgtttcct 360 cttggccgtc atggcctttg atcggtacct tgctatctgc cgtcccttgc actaccctaa 420 tatcatgact gggcatttct gtaccaaact ggtcattatc tgctgggttt gtggatttct 480 gtggttcgtg atccccattg tattcatctc tcagatgccc ttctgtggtc cgaacattat 540 tgaccatgtt gtgtgtgacc cagggccact gtttgcattg gcatgtgcct ctgccccaac 600 aacccaacag ctttgctaca ctctaagctc gttagttatc tttggtaact tcctcttcat 660 ccttggatcc tatacgcttg tcttattagc tgtgttgcgt atgccttctg ccactgggag 720 acataaggcc ttctctacct gtgggtctca tttggctgtg gtatcactct tctatggctc 780 cttgatggtc atgtatgtga gccctagact cagacattct gctggtatac agaaagttgc 840 aactttgttc tatgctatgg taaccccact cttcaacccc ctcatctata gcctccggaa 900 taaggagata aaggcagccc tgaggaaagt tctggggcat ctcaacataa tccaagatac 960 acttgatgat ccctcca 977

<210> 2636 <211> 324 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (324)..(324) <223> Any amino acid

<400> 2636 Met Asn Val Ser Glu Pro Tyr Ser Ser Phe Ala Ser Val Arg Glu Phe 1 5 10 15 Ile Leu Leu Gly Phe Ser Cys Glu Trp Lys Ile Gln Ile Leu Leu Phe 20 25 30 Ser Leu Phe Thr Thr Met Tyr Ala Leu Thr Val Thr Gly Asn Gly Ala Page 292 9

069269_0225_SL.TXT 40 45

Ile Val 50 Cys Ala Leu Trp Cys Glu 55 Trp Lys Leu His 60 Ile Pro Met Tyr Arg Phe Leu Gly Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val Ser Ser 65 70 75 80 Thr Val Pro Lys Met Leu Ile Asn Phe Leu Ser Asp Lys Lys Thr Ile 85 90 95 Ser Phe Ala Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly 100 105 110 Thr Ser Glu Cys Phe Leu Leu Ala Val Met Ala Phe Asp Arg Tyr Leu 115 120 125 Ala Ile Cys Arg Pro Leu His Tyr Pro Asn Ile Met Thr Gly His Phe 130 135 140 Cys Thr Lys Leu Val Ile Ile Cys Trp Val Cys Gly Phe Leu Trp Phe 145 150 155 160 Val Ile Pro Ile Val Phe Ile Ser Gln Met Pro Phe Cys Gly Pro Asn 165 170 175 Ile Ile Asp His Val Val Cys Asp Pro Gly Pro Leu Phe Ala Leu Ala 180 185 190 Cys Ala Ser Ala Pro Thr Thr Gln Gln Leu Cys Tyr Thr Leu Ser Ser 195 200 205 Leu Val Ile Phe Gly Asn Phe Leu Phe Ile Leu Gly Ser Tyr Thr Leu 210 215 220 Val Leu Leu Ala Val Leu Arg Met Pro Ser Ala Thr Gly Arg His Lys 225 230 235 240 Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr

Page 2930

245

255

069269_0225_SL.TXT

250

Gly Ser Leu Met Val Met Tyr Val Ser Pro Arg Leu Arg His Ser Ala 260 265 270 Gly Ile Gln Lys Val Ala Thr Leu Phe Tyr Ala Met Val Thr Pro Leu 275 280 285 Phe Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Ala Ala 290 295 300 Leu Arg Lys Val Leu Gly His Leu Asn Ile Ile Gln Asp Thr Leu Asp 305 Asp Pro Ser Xaa 310 315 320

<210> 2637 <211> 969 <212> DNA <213> Felis catus <400> 2637

atgaaaatcc cagctgaaaa caaccactct gaccctgtca gtgaattcat tcttcttggc 60 ttcccttgca cctgggaggt ccagatcctc ctcttctcaa tcttctttgt gatctatgtc 120 ctgacattaa tgggaaatct gtgtatcatc tgtgcagtgt ggtggaatga ccatctccac 180 actcccatgt acatcctact ggccaatttt tccttcctgg agatctggta tgtcacttct 240 actgtcccta atatgctggc caactttctc tctgaaacca attccatctc cttctatggc 300 tgcttcatcc agttctactt cttcttctcc atgggcacca ctgagacctt cttcttgtct 360 gccatggcct ttgacaggta ccttgctatc tgcaggcccc tgcattaccc cgctgtcatg 420 acagttcagc gctgcatcag aataggagct gggtgctggg tgtgtggctt ctcttgtttt 480 ctcctcccag tttacctgat ctcccagctt cctttttgtg gtcccaatac aattgatcat 540 tttttgtgtg atccaggacc ccttatgaat ctgtcttgtg tggcagctcc tgccactgag 600 atcatctgtg ccatctttaa ctcagtcctc attttctcca ccttcctctt cattaccagc 660 tcctacacct tggtgatcag agctgtactg agggtcccct cagcagaagg tcggcataag 720

Page 2931

069269_0225_SL.TXT gccttctcca cgtgtggctc gtgatgtatg tgagtccaac ttttattctg tgatgactcc atgaagcagg ccctgacaaa aagaactag ccatctggct gtggtgtccc agcaggcaat ccagcaggga acttttcaat cccttgatct actatttagg attatgagat tgttctatgg ctccatcatg ttcagaaaat tgtgacttta atagcctccg gaataaggag ctggtcaaag acagcctctc

780

840

900

960

969 <210> 2638 <211> 322 <212> PRT <213> Felis catus

<400> 2638 Met 1 Lys Ile Pro Ala 5 Glu Ile Leu Leu Gly Phe 20 Pro Ser Ile Phe Phe Val 35 Ile Ile Ile Cys Ala Val 50 Trp Ile 65 Leu Leu Ala Asn Phe 70 Thr Val Pro Asn Met 85 Leu Ser Phe Tyr Gly Cys 100 Phe Thr Thr Glu Thr Phe 115 Phe Ala Ile Cys Arg Pro 130 Leu

Asn Asn His Ser 10 Asp Cys Thr Trp 25 Glu Val Tyr Val 40 Leu Thr Leu Trp 55 Asn Asp His Leu Ser Phe Leu Glu Ile 75 Ala Asn Phe Leu 90 Ser Ile Gln Phe 105 Tyr Phe Leu Ser 120 Ala Met Ala His 135 Tyr Pro Ala Val

Pro Val Ser Glu 15 Phe Gln Ile Leu 30 Leu Phe Met Gly 45 Asn Leu Cys His 60 Thr Pro Met Tyr Trp Tyr Val Thr Ser 80 Glu Thr Asn Ser 95 Ile Phe Phe Ser 110 Met Gly Phe Asp 125 Arg Tyr Leu Met 140 Thr Val Gln Arg

Page 2932

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Cys Ile Arg Ile Gly Ala Gly Cys Trp Val Cys Gly Phe Ser Cys Phe 145 150 155 160 Leu Leu Pro Val Tyr Leu Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn 165 170 175 Thr Ile Asp His Phe Leu Cys Asp Pro Gly Pro Leu Met Asn Leu Ser 180 185 190 Cys Val Ala Ala Pro Ala Thr Glu Ile Ile Cys Ala Ile Phe Asn Ser 195 200 205 Val Leu Ile Phe Ser Thr Phe Leu Phe Ile Thr Ser Ser Tyr Thr Leu 210 215 220 Val Ile Arg Ala Val Leu Arg Val Pro Ser Ala Glu Gly Arg His Lys 225 230 235 240 Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr 245 250 255 Gly Ser Ile Met Val Met Tyr Val Ser Pro Thr Ala Gly Asn Pro Ala 260 265 270 Gly Ile Gln Lys Ile Val Thr Leu Phe Tyr Ser Val Met Thr Pro Leu 275 280 285 Phe Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Met Lys Gln Ala 290 295 300 Leu Thr Lys Leu Phe Arg Ile Met Arg Ser Gly Gln Arg Gln Pro Leu 305 310 315 320

Lys Asn <210> 2639 <211> 969

Page 2933

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 2639

atgagtatgt cagaagccaa caatatctct gggtctgtga gtgagttcat cctcctgggc 60 ttcccatgcc gcagggagat ccagatcctc ctctttgtca tcttctccct catctacctt 120 ctgactctca tggggaacac atccatcatc tgtgccgtgt ggtcaagccg gaaactccac 180 acacccatgt acatcctcct ggccaacttc tccttcctgg agatctgcta tgtcagttct 240 gatgtgccca aaatgttggc caacatcatc tcccagacta agagtatctc ctatgctggc 300 tgcctgcttc agttctactt tttcttttct atgtgtgctg ctgaaggcta ctttctgtct 360 gcaatgtcct ttgatcggtt ccttgctatc tgtcgacctc tacgttaccc caccatcatg 420 acttaccatc tatgtgcccg attagtggtt ttctgctggg taggtggctt tctatccata 480 ctcatgcctg cagttctcat gtcccaggtg cccttctgtg gccctaacat cattgaccat 540 tttttctgtg acctgggacc attgctagcc ctgtcctgtg ctccagttcc caaaactact 600 ctaacttgtg ctactgtaag ttctcttatc atctttatca ccttcctcta cattctaggg 660 tcgtatagct tagttttgcg tgctgtactt cgggtcccag ctggctcagg taggaacaaa 720 gccttttcta catgtgcctc acatttcttg gtggtttccc tgttctatgg atcagtcatg 780 gtgatgtatg tgagtccagg ttccaggagc catcctggaa cacagaaatt tgtgaccctg 840 ttttactgca tggcaacccc attctttaat cctttgattt acagtcttcg gaacaaagat 900 atgaaagatg cactcaagaa agtcctggga gcaccatcaa aagaaattac taaaaataaa 960

gagaaatga 969 <210> 2640 <211> 322 <212> PRT <213> Felis catus <400> 2640

Met Ser Met Ser Glu Ala Asn Asn Ile Ser Gly Ser Val Ser Glu Phe 1 5 10 15

Ile Leu Leu Gly Phe Pro Cys Arg Arg Glu Ile Gln Ile Leu Leu Phe 20 25 30

Page 2934

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Val Ile Phe 35 Ser Leu Ile Tyr Leu Leu Thr Leu Met Gly Asn Thr Ser 40 45 Ile Ile Cys Ala Val Trp Ser Ser Arg Lys Leu His Thr Pro Met Tyr 50 55 60 Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val Ser Ser 65 70 75 80 Asp Val Pro Lys Met Leu Ala Asn Ile Ile Ser Gln Thr Lys Ser Ile 85 90 95 Ser Tyr Ala Gly Cys Leu Leu Gln Phe Tyr Phe Phe Phe Ser Met Cys 100 105 110 Ala Ala Glu Gly Tyr Phe Leu Ser Ala Met Ser Phe Asp Arg Phe Leu 115 120 125 Ala Ile Cys Arg Pro Leu Arg Tyr Pro Thr Ile Met Thr Tyr His Leu 130 135 140 Cys Ala Arg Leu Val Val Phe Cys Trp Val Gly Gly Phe Leu Ser Ile 145 150 155 160 Leu Met Pro Ala Val Leu Met Ser Gln Val Pro Phe Cys Gly Pro Asn 165 170 175 Ile Ile Asp His Phe Phe Cys Asp Leu Gly Pro Leu Leu Ala Leu Ser 180 185 190 Cys Ala Pro Val Pro Lys Thr Thr Leu Thr Cys Ala Thr Val Ser Ser 195 200 205 Leu Ile Ile Phe Ile Thr Phe Leu Tyr Ile Leu Gly Ser Tyr Ser Leu 210 215 220 Val Leu Arg Ala Val Leu Arg Val Pro Ala Gly Ser Gly Arg Asn Lys 225 230 235 240

Page 2935

069269_0225_SL.TXT

Ala Phe Ser Thr Cys Ala Ser His Phe Leu Val Val Ser Leu Phe Tyr 245 250 255 Gly Ser Val Met Val Met Tyr Val Ser Pro Gly Ser Arg Ser His Pro 260 265 270 Gly Thr Gln Lys Phe Val Thr Leu Phe Tyr Cys Met Ala Thr Pro Phe 275 280 285 Phe Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala 290 295 300 Leu Lys Lys Val Leu Gly Ala Pro Ser Lys Glu Ile Thr Lys Asn Lys 305 310 315 320

Glu Lys <210> 2641 <211> 902 <212> DNA <213> Felis catus <400> 2641 tttcttgagt gcctctttca tatctttgtt ccagaagttg taaatcaaag gattaaagag tggggttgcg aaagcataga acaaggtcac aaatttctgc atcccaggat agtccccaga atctgggcta atgtacatca ccatgactga accatagaac agacacacca cagcaaggtg ggaggcacaa gtaaagaaag ccttatgcct tcctgagcct gggggcacct ataacaccac actcaagaca cagaactaag tgccatgtac aggaaagtga gaaagatgat gagagagctg ttgataccac atatttgagt aatttcacat actggagcac aggacaatgc cagcaaaagt gcaagatcac agagaaaatg gtcagtggtg tttggaccac agaaaggcac ctgagatatt agagtcaaag gagtcagtaa ccagagaaag cccctaccca gcagaagacc actaactgaa agcataggcg gtgggtcatt atggtaggat agcggaaagg tctacaaatg gcaagtaatc aatcaaaaga catcactgac agaaataagc cctcagcggc acacatggaa aagaagtaga actggagcag gcagccagca taggagatac tcttagtctg ggagatgatg ttggccaaca

120

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360

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Page 2936

069269_0225_SL.TXT ttttgggcac atcagaactg acatagcaga gctccaggaa ggagaagttg gccaggagga tgtacatggg tgcgtggagt ttccggcttg accacatggc acagatgatg gatgtgttcc ccatgagagt cagaaggtag atgagggaga agatgacaaa gaggaggatc tggatctccc tgtggcatgg gaagcccagg aggatgaact cactcacaga cccagagatg atagtagtct cc

720

780

840

900

902 <210> 2642 <211> 120 <212> PRT <213> Felis catus <400> 2642

Glu Thr Thr Ile Ile Ser Gly Ser Val Ser Glu Phe Ile Leu Leu Gly 1 5 10 15 Phe Pro Cys His Arg Glu Ile Gln Ile Leu Leu Phe Val Ile Phe Ser 20 25 30 Leu Ile Tyr Leu Leu Thr Leu Met Gly Asn Thr Ser Ile Ile Cys Ala 35 40 45 Met Trp Ser Ser Arg Lys Leu His Ala Pro Met Tyr Ile Leu Leu Ala 50 55 60 Asn Phe Ser Phe Leu Glu Leu Cys Tyr Val Ser Ser Asp Val Pro Lys 65 70 75 80 Met Leu Ala Asn Ile Ile Ser Gln Thr Lys Ser Ile Ser Tyr Ala Gly 85 90 95 Cys Leu Leu Gln Phe Tyr Phe Phe Ser Met Cys Ala Ala Glu Gly Leu 100 105 110 Phe Leu Ser Val Met Ser Phe Asp 115 120

<210> 2643 <211> 942

Page 2937

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 2643

atgacttcgg aggccagaaa tatttctcac actgtgagtg agttcatcct cttgggcttt 60 ccttgccgtt gggaaatgca gatcctcctc ttttccatat tctttgtgac ttacatcatg 120 acgctccttg gaaacatggc catcgtgtgt gtggtgcgct gggaccgccg gctccacacc 180 cccatgtata ttctgctggc caacttctcc ttcctggaaa tctgttatgt caactctgat 240 gtgcccaaca tgctggccaa cttcctctcc cagaccaaaa ccatctcctt tgcttggtgc 300 ctcctccagt tgtacttctt cttctcacta ggcacaactg aatgcttatt tctgtccatc 360 atggcctatg accggttcct ggcaatctgt caccccctgc attaccccac catcatgact 420 gtgaagttct gttgcagcct ggtcatcttt tgctgggtct atggttttct ctggtttctg 480 atcccagtga tacttgttac ccagctacca ttttgtggcc caaacgtgat tgatgacttc 540 ctgtgtgacc tgggtcctct gctggccttg gcttcagcct gtgtcccaat cccagggact 600 attctcatat gtggcaccat gagctcactc ctcatctttg ccaccttttt ctacattact 660 ggctcctata ccctggtgct gagggctgta gtgcaggtgc cctcagttgc tggccggaag 720 aaggcctttt ctacgtgctc ctcacatctg gctgttgtgt ttctattcta tggctctgtc 780 atgatgacat atgtgagccc ggggtcagga caagcagaag gaatgcagaa gttcacaact 840 ctattctact cagttctgac cccttttttt aaccccatga tctacagcct ccggaataaa 900 gaaatgaagg atgccttgaa gaaagttcta ggaggtttct aa 942

<210> 2644 <211> 313 <212> PRT <213> Felis catus

<400> 2644 Met Thr Ser Glu Ala Arg Asn Ile Ser His Thr Val Ser Glu Phe Ile 1 5 10 15 Leu Leu Gly Phe Pro Cys Arg Trp Glu Met Gln Ile Leu Leu Phe Ser 20 25 30 Ile Phe Phe Val Thr Tyr Ile Met Thr Leu Leu Gly Asn Met Ala Ile Page 293 8

069269_0225_SL.TXT 40 45

Val Cys Val Val Arg Trp Asp Arg Arg Leu His Thr Pro Met Tyr Ile 50 55 60 Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val Asn Ser Asp 65 70 75 80 Val Pro Asn Met Leu Ala Asn Phe Leu Ser Gln Thr Lys Thr Ile Ser 85 90 95 Phe Ala Trp Cys Leu Leu Gln Leu Tyr Phe Phe Phe Ser Leu Gly Thr 100 105 110 Thr Glu Cys Leu Phe Leu Ser Ile Met Ala Tyr Asp Arg Phe Leu Ala 115 120 125 Ile Cys His Pro Leu His Tyr Pro Thr Ile Met Thr Val Lys Phe Cys 130 135 140 Cys Ser Leu Val Ile Phe Cys Trp Val Tyr Gly Phe Leu Trp Phe Leu 145 150 155 160 Ile Pro Val Ile Leu Val Thr Gln Leu Pro Phe Cys Gly Pro Asn Val 165 170 175 Ile Asp Asp Phe Leu Cys Asp Leu Gly Pro Leu Leu Ala Leu Ala Ser 180 185 190 Ala Cys Val Pro Ile Pro Gly Thr Ile Leu Ile Cys Gly Thr Met Ser 195 200 205 Ser Leu Leu Ile Phe Ala Thr Phe Phe Tyr Ile Thr Gly Ser Tyr Thr 210 215 220 Leu Val Leu Arg Ala Val Val Gln Val Pro Ser Val Ala Gly Arg Lys 225 230 235 240 Lys Ala Phe Ser Thr Cys Ser Ser His Leu Ala Val Val Phe Leu Phe

Page 2939

245 069269_0225_SL.TXT 250 255 Tyr Gly Ser Val Met Met Thr Tyr Val Ser Pro Gly Ser Gly Gln Ala 260 265 270 Glu Gly Met Gln Lys Phe Thr Thr Leu Phe Tyr Ser Val Leu Thr Pro 275 280 285 Phe Phe Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys Glu Met Lys Asp 290 295 300 Ala Leu Lys Lys Val Leu Gly Gly Phe 305 310

<210> 2645 <211> 936 <212> DNA <213> Felis catus <400> 2645 atgaatatct ccaacacccc caacacctcc agcaccttca ctggcttcat cctcctgggc 60 ttcccttgct ccagggaggg gcagatcctc ctctttgtgc tcttctctgt tgtctacctc 120 ctgaccctca tgggcaacgg gtccatcatc tgtgctgtgc gctgggatca gagactccac 180 acccccatgt acatcttgct cgccaacttc tccttcctag agatctggta tgtcacctcc 240 actgtcccca acatgttagc caacttcctc tctgacacca aggtcatctc cttctctggg 300 tgctttctcc agttctactt tttcttctcc ttgggttcta cagaatgctt tttcttggcc 360 attatggcat ttgatcggta ccttgccgtc tgctggcctc tacactatcc aaccattatg 420 actggacgtc tctgcaccaa tcttgtgatc agctgctggg tatttggttt cctctggttc 480 ttgattccca tcatcatcat ctcacaaatg tccttctgtg gatccaggat tattgaccac 540 ttcctgtgtg atcctggtcc cctgttggcc ctcacctgta ctagagcccc tgcaatagag 600 ttaactagct ccaccttaag ttctctgctc ttatttattc cctttttctt tatcgtggtg 660 tcctacgctc ttgttctgag agctgtgttg agggtccctt cagcagctgg acgaagaaaa 720 gctttctcca cctgtgggtc ccatctggca gtggtttcac tgttctatgg ctcagtgatg 780 gtcatgtatg tgagcccaac atctgagcgt gaagctggga tgcagaagat ggtgactttg 840

Page 2940

069269_0225_SL.TXT ttttattctg taattactcc actcatcaac cctataatat atagtctgag gaacaaagat atgaaacatg ctatgaaaac attgttgaga acataa

900

936 <210> 2646 <211> 311 <212> PRT <213> Felis catus

<400> 2646 Thr Pro Asn Thr Ser Ser Thr Phe Thr Gly Phe Met Asn 1 Ile Ser Asn 5 10 15 Ile Leu Leu Gly Phe Pro Cys Ser Arg Glu Gly Gln Ile Leu Leu Phe 20 25 30 Val Leu Phe Ser Val Val Tyr Leu Leu Thr Leu Met Gly Asn Gly Ser 35 40 45 Ile Ile Cys Ala Val Arg Trp Asp Gln Arg Leu His Thr Pro Met Tyr 50 55 60 Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val Thr Ser 65 70 75 80 Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Val Ile 85 90 95 Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly 100 105 110 Ser Thr Glu Cys Phe Phe Leu Ala Ile Met Ala Phe Asp Arg Tyr Leu 115 120 125 Ala Val Cys Trp Pro Leu His Tyr Pro Thr Ile Met Thr Gly Arg Leu 130 135 140 Cys Thr Asn Leu Val Ile Ser Cys Trp Val Phe Gly Phe Leu Trp Phe 145 150 155 160

Page 2941

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Leu Ile Pro Ile Ile Ile Ile Ser Gln Met 170 Ser Phe Cys Gly Ser 175 Arg 165 Ile Ile Asp His Phe Leu Cys Asp Pro Gly Pro Leu Leu Ala Leu Thr 180 185 190 Cys Thr Arg Ala Pro Ala Ile Glu Leu Thr Ser Ser Thr Leu Ser Ser 195 200 205 Leu Leu Leu Phe Ile Pro Phe Phe Phe Ile Val Val Ser Tyr Ala Leu 210 215 220 Val Leu Arg Ala Val Leu Arg Val Pro Ser Ala Ala Gly Arg Arg Lys 225 230 235 240 Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr 245 250 255 Gly Ser Val Met Val Met Tyr Val Ser Pro Thr Ser Glu Arg Glu Ala 260 265 270 Gly Met Gln Lys Met Val Thr Leu Phe Tyr Ser Val Ile Thr Pro Leu 275 280 285 Ile Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys His Ala 290 295 300 Met Lys Thr Leu Leu Arg Thr 305 310 <210> 2647 <211> 916 <212> DNA <213> Felis catus <400> 2647 caacacctcc agcaccatca ctggcttcat cctcctgggc ttcccttgct ccagggaggg gcagatcctc ctctttgtgc tcttctctgt tgtctacctc ctgaccctca tgggcaacgg gtccatcatc tgtgctgtgc gctgggatca gagactccac acccccatgt acatcttgct

120

180

Page 2942

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cgccaacttc tccttcctag agatctggta tgtcacctcc actgtcccca acatgttagc 240 caacttcctc tctgacacca aggtcatctc cttctctggg tgctttctcc agttctactt 300 tttcttctcc ttgggttcta cagaatgctt cttcttggct attatggcat ttgatcggta 360 ccttgccatc tgctggcctc tacattaccc cactcttatg actggacatc tctgcaccaa 420 ccttgtggtc agctgctggg tacttggttt cctttggttc ccagtaccta tcattgttat 480 ttcccaaatg tccttctgtg gatccaggat cattgaccac ttcctgtgtg atccaggtcc 540 cctattagca ctcacctgtg ccagagtccc agtaatggag tttttttgga ctattataag 600 ttccttgctc ttatttattc ctttcctctg catcatgggg tcctatactc tggtcctgag 660 agctgtgttt agagtccctt cagcagctgg acgaagaaaa gctttctcga cctgtgggtc 720 ccatctggcc gtggtttcac tgttctatgg ttcggtgatg gtcatgtatc tgagcccaac 780 atctgagcat gaggctggga tgcagaaact tgtgactctg ttttattctg taggaacccc 840 actcattaat cctgtgatct acagtctaag gaacaaagat atgaaatatg ccctgcagaa 900 atttctagga atataa 916

<210> 2648 <211> 304 <212> PRT <213> Felis catus <400> 2648

Asn Thr Ser Ser Thr Ile Thr Gly Phe Ile Leu Leu Gly Phe Pro Cys 1 5 10 15 Ser Arg Glu Gly Gln Ile Leu Leu Phe Val Leu Phe Ser Val Val Tyr 20 25 30 Leu Leu Thr Leu Met Gly Asn Gly Ser Ile Ile Cys Ala Val Arg Trp 35 40 45 Asp Gln Arg Leu His Thr Pro Met Tyr Ile Leu Leu Ala Asn Phe Ser 50 55 60 Phe Leu Glu Ile Trp Tyr Val Thr Ser Thr Val Pro Asn Met Leu Ala 65 70 75 80

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Asn Phe Leu Ser Asp 85 Thr Lys Val Ile Ser Phe Ser Gly Cys Phe Leu 90 95 Gln Phe Tyr Phe Phe Phe Ser Leu Gly Ser Thr Glu Cys Phe Phe Leu 100 105 110 Ala Ile Met Ala Phe Asp Arg Tyr Leu Ala Ile Cys Trp Pro Leu His 115 120 125 Tyr Pro Thr Leu Met Thr Gly His Leu Cys Thr Asn Leu Val Val Ser 130 135 140 Cys Trp Val Leu Gly Phe Leu Trp Phe Pro Val Pro Ile Ile Val Ile 145 150 155 160 Ser Gln Met Ser Phe Cys Gly Ser Arg Ile Ile Asp His Phe Leu Cys 165 170 175 Asp Pro Gly Pro Leu Leu Ala Leu Thr Cys Ala Arg Val Pro Val Met 180 185 190 Glu Phe Phe Trp Thr Ile Ile Ser Ser Leu Leu Leu Phe Ile Pro Phe 195 200 205 Leu Cys Ile Met Gly Ser Tyr Thr Leu Val Leu Arg Ala Val Phe Arg 210 215 220 Val Pro Ser Ala Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys Gly Ser 225 230 235 240 His Leu Ala Val Val Ser Leu Phe Tyr Gly Ser Val Met Val Met Tyr 245 250 255 Leu Ser Pro Thr Ser Glu His Glu Ala Gly Met Gln Lys Leu Val Thr 260 265 270 Leu Phe Tyr Ser Val Gly Thr Pro Leu Ile Asn Pro Val Ile Tyr Ser 275 280 285

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Leu Arg Asn Lys Asp Met Lys Tyr Ala Leu Gln Lys Phe Leu Gly Ile 290 295 300 <210> 2649 <211> 936 <212> DNA <213> Felis catus <400> 2649

atgaatatct ccaacacccc caacacctcc agcaccatca ctggcttcat cctcctgggc 60 ttcccttgct ccagggaggg gcagatcctc ctctttgtgc tcttctctgt tgtctacctc 120 ctgaccctca tgggcaacgg gtccatcatc tgtgctgtgc gctgggatca gagactccac 180 acccccatgt acatcttgct cgccaacttc tccttcctag agatctggta tgtcacctcc 240 actgtcccca acatgttagc caacttcctc tctgacacca aggtcatctc cttctctggg 300 tgctttctcc agttctactt tttcttctcc ttgggttcta cagaatgctt cttcttggct 360 attatggcat ttgatcggta ccttgccatc tgccggcctc tacactatcc aaccattatg 420 actggccgtc tctgcaccaa tcttgtggta agctgctggg tatttggttt cctttggttc 480 ttgattccca tcatcatcat ctcacaaatg tccttctgtg gatccaggat tattgaccac 540 ttcctctgtg atccaggtcc tcttctaaca ctcacctgca aaaaagctcc tgtggtagag 600 attatcttct ccactttaag tcctctgccc ctcgttattc cctttctctt catcatggga 660 tcctatgctc tggtcctaag agcagtgttg aaagtccctt cagcagctgg gaaaagaaag 720 gctttctcca cctgtgggtc tcatctggcc gtggtttcac tgttctatgg ctcagtactg 780 gtcatgtatg ggagcccaac atctgagcat gaagctggaa cacagaagat tgtgactctg 840 ttttattctg ttgtgacccc actccttaat ccagtgatat acagtcttag gaacaaagat 900 atgaaaaata ccctgcagaa atttctggaa atataa 936

<210> 2650 <211> 311 <212> PRT <213> Felis catus <400> 2650

Met Asn Ile Ser Asn Thr Pro Asn Thr Ser Ser Thr Ile Thr Gly Phe 1 5 10 15

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Ile Leu Leu Gly 20 Phe Pro Cys Ser Arg Glu Gly Gln Ile Leu Leu Phe 25 30 Val Leu Phe Ser Val Val Tyr Leu Leu Thr Leu Met Gly Asn Gly Ser 35 40 45 Ile Ile Cys Ala Val Arg Trp Asp Gln Arg Leu His Thr Pro Met Tyr 50 55 60 Ile Leu Leu Ala Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val Thr Ser 65 70 75 80 Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Asp Thr Lys Val Ile 85 90 95 Ser Phe Ser Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly 100 105 110 Ser Thr Glu Cys Phe Phe Leu Ala Ile Met Ala Phe Asp Arg Tyr Leu 115 120 125 Ala Ile Cys Arg Pro Leu His Tyr Pro Thr Ile Met Thr Gly Arg Leu 130 135 140 Cys Thr Asn Leu Val Val Ser Cys Trp Val Phe Gly Phe Leu Trp Phe 145 150 155 160 Leu Ile Pro Ile Ile Ile Ile Ser Gln Met Ser Phe Cys Gly Ser Arg 165 170 175 Ile Ile Asp His Phe Leu Cys Asp Pro Gly Pro Leu Leu Thr Leu Thr 180 185 190 Cys Lys Lys Ala Pro Val Val Glu Ile Ile Phe Ser Thr Leu Ser Pro 195 200 205 Leu Pro Leu Val Ile Pro Phe Leu Phe Ile Met Gly Ser Tyr Ala Leu 210 215 220

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Val Leu 225 Arg Ala Val Leu Lys Val Pro Ser Ala Ala Gly Lys Arg Lys 230 235 240 Ala Phe Ser Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr 245 250 255 Gly Ser Val Leu Val Met Tyr Gly Ser Pro Thr Ser Glu His Glu Ala 260 265 270 Gly Thr Gln Lys Ile Val Thr Leu Phe Tyr Ser Val Val Thr Pro Leu 275 280 285 Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asn Thr 290 295 300 Leu Gln Lys Phe Leu Glu Ile

305 310 <210> 2651 <211> 900 <212> DNA <213> Felis catus <400> 2651

atgaacagtt cagagacaag cactgtgact gagtttgtcc tcctaggctt ccctggttgt 60 caggagttgc aaagtttcct tttctcactg ttcttgggga tctatatatt taccataatg 120 ggaaatggga ttattgtctg tgctgtgagg ttggaccaac ggctccatac cccaatgtat 180 attctcctag gcaattttgc tttccttgaa atcttgtaca ttacctccac tgtgcccagt 240 atgctagtca atttcctctc agaaacaaaa accatctctt tcgttggctg tttcctccag 300 ttatattttt ttacttccct tggtacaact gaggcatatt tcctctgcat catggcatat 360 gatcggtacc tcgctatctg ccacccactg cactactcaa ccaccatgac ccaacagctc 420 tgctatatct tgatgtctct ttgctgggtg ttggggttcc ttagttactc tgtctccact 480 atacagctct ctcaattgcc tttctgtgga cccaacacca ttgaccactt tatgtgtgac 540 atggacccac tgatggctct gtcctgtgct acagctccag tcatggagat catcttctat 600

Page 2947

069269_0225_SL.TXT gtcctgaact ccctcatcat catcctcaca cttctgtata ttcttggctc ctatactctt ttactgatag ctgtgttaaa agtgccttca gctgctggcc tgcggaaggc cttttccacc tgcggatcac atctgacagt ggtatgctta ttctttggag cccttttggc aatgtatgtg agtcccacag ctgataaccc agatgaaatt cagaagattt tgactctgtt ctactccgtg gtgactccct tcttaaaccc tctgatttac agtttacgaa acaaggacat gaaggctgca

660

720

780

840

900 <210> 2652 <211> 300 <212> PRT <213> Felis catus <400> 2652

Met Asn Ser 1 Ser Glu Thr Ser Thr 5 Val Thr Glu Phe Val Leu Leu Gly 10 15 Phe Pro Gly Cys Gln Glu Leu Gln Ser Phe Leu Phe Ser Leu Phe Leu 20 25 30 Gly Ile Tyr Ile Phe Thr Ile Met Gly Asn Gly Ile Ile Val Cys Ala 35 40 45 Val Arg Leu Asp Gln Arg Leu His Thr Pro Met Tyr Ile Leu Leu Gly 50 55 60 Asn Phe Ala Phe Leu Glu Ile Leu Tyr Ile Thr Ser Thr Val Pro Ser 65 70 75 80 Met Leu Val Asn Phe Leu Ser Glu Thr Lys Thr Ile Ser Phe Val Gly 85 90 95 Cys Phe Leu Gln Leu Tyr Phe Phe Thr Ser Leu Gly Thr Thr Glu Ala 100 105 110 Tyr Phe Leu Cys Ile Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys His 115 120 125 Pro Leu His Tyr Ser Thr Thr Met Thr Gln Gln Leu Cys Tyr Ile Leu 130 135 140

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Met 145 Ser Leu Cys Trp Val 150 Leu Gly Phe Leu Ser 155 Tyr Ser Val Ser Thr 160 Ile Gln Leu Ser Gln Leu Pro Phe Cys Gly Pro Asn Thr Ile Asp His 165 170 175 Phe Met Cys Asp Met Asp Pro Leu Met Ala Leu Ser Cys Ala Thr Ala 180 185 190 Pro Val Met Glu Ile Ile Phe Tyr Val Leu Asn Ser Leu Ile Ile Ile 195 200 205 Leu Thr Leu Leu Tyr Ile Leu Gly Ser Tyr Thr Leu Leu Leu Ile Ala 210 215 220 Val Leu Lys Val Pro Ser Ala Ala Gly Leu Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Cys Leu Phe Phe Gly Ala Leu Leu 245 250 255 Ala Met Tyr Val Ser Pro Thr Ala Asp Asn Pro Asp Glu Ile Gln Lys 260 265 270 Ile Leu Thr Leu Phe Tyr Ser Val Val Thr Pro Phe Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Ala Ala 290 295 300

<210> 2653 <211> 993 <212> DNA <213> Felis catus <400> 2653 atgttcattg ttattcactc cttcgttact tctatttctc taacagcttt ggaatctcag aacgcaacaa tgcattttgt gactgagttt gtcctcctgg gttttcctgg tcaaagggag atgcagaact ttttcttctc attaatcctt gtggtctatc tcctcactct gctggggaat

120

180

Page 2949

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ggggttattg tctatgtagt gaaatgggac aagcggcttc acacacccat gtacatcctc 240 ttgggaaact ttgccttcct agagatctgg tacatctcct ccactgtccc aaacatgctg 300 gtcaccatcc tctctgagac caagaccatc tccttcactg gatgcttcct ccaattttat 360 ttctttttct cattgggtac aacagagtgt ttcttcttat cagttatggc ttatgaccgg 420 taccttgcca tctgtcgccc actacattat ccttccatca tgactgggaa gctctgtgtg 480 atcctggtct gcgtttgctg ggtgagtgga tttctctgct atccaatccc cattgtcctc 540 atctcccaac ttcccttctg tggacctaac atcattgacc acttcgtgtg tgacccaggc 600 ccattgttcg cactggcctg catccctgct ccttccactg aacttatctg ctataccttc 660 aactcagtga ttatctttgg gcccttcctt tctatcttgg gatcttacac tctggtactc 720 agagctgtgc ttcgtattcc ttctggtgct ggtcaaacta aagctttctc cacatgtggg 780 tcacacctaa tggtggtgtc tctattctat ggaaccctta tggtgatgta tgtaagccca 840 acatcaggaa atccagcagg aatgcagaag atcgtcactt tggtatactc agcagtgact 900 ccactcttaa acccccttat ctatagtctt cgaaataaag acatgaaaga tgccctaaag 960 aaactcctag gattaagaag taacccaaac tga 993

<210> 2654 <211> 330 <212> PRT <213> Felis catus

<400> 2654 His Ser Phe Val Thr Ser Ile Ser Leu Thr Ala Met 1 Phe Ile Val Ile 5 10 15 Leu Glu Ser Gln Asn Ala Thr Met His Phe Val Thr Glu Phe Val Leu 20 25 30 Leu Gly Phe Pro Gly Gln Arg Glu Met Gln Asn Phe Phe Phe Ser Leu 35 40 45 Ile Leu Val Val Tyr Leu Leu Thr Leu Leu Gly Asn Gly Val Ile Val 50 55 60

Page 2950

Tyr 65 Val Val Lys Trp Asp 70 Lys 069269_0225_SL.TXT Arg Leu His Thr Pro Met 75 Tyr Ile Leu 80 Leu Gly Asn Phe Ala Phe Leu Glu Ile Trp Tyr Ile Ser Ser Thr Val 85 90 95 Pro Asn Met Leu Val Thr Ile Leu Ser Glu Thr Lys Thr Ile Ser Phe 100 105 110 Thr Gly Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr 115 120 125 Glu Cys Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile 130 135 140 Cys Arg Pro Leu His Tyr Pro Ser Ile Met Thr Gly Lys Leu Cys Val 145 150 155 160 Ile Leu Val Cys Val Cys Trp Val Ser Gly Phe Leu Cys Tyr Pro Ile 165 170 175 Pro Ile Val Leu Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn Ile Ile 180 185 190 Asp His Phe Val Cys Asp Pro Gly Pro Leu Phe Ala Leu Ala Cys Ile 195 200 205 Pro Ala Pro Ser Thr Glu Leu Ile Cys Tyr Thr Phe Asn Ser Val Ile 210 215 220 Ile Phe Gly Pro Phe Leu Ser Ile Leu Gly Ser Tyr Thr Leu Val Leu 225 230 235 240 Arg Ala Val Leu Arg Ile Pro Ser Gly Ala Gly Gln Thr Lys Ala Phe 245 250 255 Ser Thr Cys Gly Ser His Leu Met Val Val Ser Leu Phe Tyr Gly Thr 260 265 270

Page 2951

Leu Met Val 275 Met Tyr Val Ser 069269_0225_SL.TXT Pro Thr Ser Gly Asn Pro 280 285 Ala Gly Met Gln Lys Ile Val Thr Leu Val Tyr Ser Ala Val Thr Pro Leu Leu Asn 290 295 300 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Lys 305 310 315 320 Lys Leu Leu Gly Leu Arg Ser Asn Pro Asn 325 330

<210> 2655 <211> 945 <212> DNA <213> Felis catus <400> 2655

atgaataagt cagggatatc tactgtgaca cagtttgtct tgttgggttt tcctggtccc 60 tggaaaatac agatcatcct tttctcaatg gttttgttgg tctacatctt gactctgact 120 gggaatatgg ccatcatttg tgcagtgagg tgggaccatc gactccatac acctatgtat 180 gtgctcctgg ccaacttctc ctttctagag atctggtatg tgacctgcac agtccccaac 240 atgctggtca attttctttc caaaactaag accatatcat tctctggctg cttcactcaa 300 ttctacttct tcttttccct gggcacaact gagtgcttct tcctctgtgt catggcctat 360 gatcggtacc tggccatctg ccgtccactg cactatccct ccattatgac cgggaagctc 420 tgtgtcattc tggtgtgtct ttgttggctc attggtttcc ttggacatgc aattactatt 480 ttcttcattt ctcaactacc cttttgtggt cccaacatta ttgatcactt cctgtgtgat 540 gtggacccac tgatggcatt gtcctgtgcc cccacaccaa tcatagagta tgtattccac 600 tttgtgagct ctcttatcat cattctcacc attttgtaca ttattgggtc ctatgcctta 660 gtgctcagag ctgtgcttca ggttccttct tcagctgggc ggcaaaaggc cttctctacc 720 tgtggatccc acttagctgt ggtgtctcta ttctatggaa ccataatggt gatgtatgtg 780 agtcctacat ctggcaactc agttgctatg tataagatca tcacactgat atactctgta 840 gtgacaccag tcttaaaccc cctcatctat agcttacgca acagggaaat gaaatttgct 900

Page 2952

945

069269_0225_SL.TXT ctccgtcagg tcatttgtgg aataagaatc atccaaccct catga <210> 2656 <211> 314 <212> PRT <213> Felis catus <400> 2656

Met 1 Asn Lys Ser Gly 5 Ile Ser Thr Val Thr Gln Phe Val Leu Leu Gly 10 15 Phe Pro Gly Pro Trp Lys Ile Gln Ile Ile Leu Phe Ser Met Val Leu 20 25 30 Leu Val Tyr Ile Leu Thr Leu Thr Gly Asn Met Ala Ile Ile Cys Ala 35 40 45 Val Arg Trp Asp His Arg Leu His Thr Pro Met Tyr Val Leu Leu Ala 50 55 60 Asn Phe Ser Phe Leu Glu Ile Trp Tyr Val Thr Cys Thr Val Pro Asn 65 70 75 80 Met Leu Val Asn Phe Leu Ser Lys Thr Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Phe Thr Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr Glu Cys 100 105 110 Phe Phe Leu Cys Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Pro Ser Ile Met Thr Gly Lys Leu Cys Val Ile Leu 130 135 140 Val Cys Leu Cys Trp Leu Ile Gly Phe Leu Gly His Ala Ile Thr Ile 145 150 155 160 Phe Phe Ile Ser Gln Leu Pro Phe Cys Gly Pro Asn Ile Ile Asp His 165 170 175

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Phe Leu Cys Asp Val Asp Pro Leu Met Ala Leu Ser Cys Ala Pro Thr 180 185 190 Pro Ile Ile Glu Tyr Val Phe His Phe Val Ser Ser Leu Ile Ile Ile 195 200 205 Leu Thr Ile Leu Tyr Ile Ile Gly Ser Tyr Ala Leu Val Leu Arg Ala 210 215 220 Val Leu Gln Val Pro Ser Ser Ala Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Ile Met 245 250 255 Val Met Tyr Val Ser Pro Thr Ser Gly Asn Ser Val Ala Met Tyr Lys 260 265 270 Ile Ile Thr Leu Ile Tyr Ser Val Val Thr Pro Val Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Glu Met Lys Phe Ala Leu Arg Gln Val 290 295 300 Ile Cys Gly Ile Arg Ile Ile Gln Pro Ser

305 310 <210> 2657 <211> 944 <212> DNA <213> Felis catus <400> 2657 tcatttgctt tgactaattt ttgtgcacat atgaattttt ctcaaggcag ccttcacgtc attgttccgg agactgtaga tcagtgggtt tataagtggg gtcactgatg agtagaacaa ggttacaatc ttctgtatcc cagctgcatt tccagaggtt gggctgatgt acatgaccat gatggatcca tagaagagag acaccacagt caggtgggag ccacaggtgg agaaggcctt acgtcggcca gctgctgaag ggacacgcaa cactgctctg agaaccaggg tgtaggatgc

120

180

240

300

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aaggatgaag aagaagctga tgaagataat aagagagctc aatatagaac aggaaagctc 360 aattccaggg gcagggatgc aggacagagc cagaagagga ccagggtcac agacaaagtg 420 gtcaatggta ttggggccac aaaaggggag ttgtgtgata aaatagatag ggactggata 480 gcagaggaag gctgtgaccc agcagagggc caccaggttc atgcagaagt ggctactcat 540 gatgttagga taatggagag gccgacagat ggccaagtac cgatcaaagc catgaggggc 600 agtaagaaag tctcagtaat gcccatggag aagaagaaat agaactggaa gaagcaagca 660 gtgaaagaga tggttttggt ctcagatagg aagttcttta acatattggg aacagtggtg 720 ttgatgtaac agatctccag gaatgagaag ttggacagca gaatgtacat gggggtgtga 780 agcctgtgat ccagcttcac tgcacagaca atggccccgt tccccatcag tgtcaggatg 840 taggacacaa agaacaacac gaaaaggagg acctgaatct ctctggagca cggaaaactc 900 agtagtatga attcggtcac tgtgctgact cctgacatat tcat 944

<210> 2658 <211> 179 <212> PRT <213> Felis catus

<400> 2658 Phe Cys 5 Met Asn Leu Val Ala Leu Cys Trp Val Thr Met Ser 1 Ser His 10 15 Ala Phe Leu Cys Tyr Pro Val Pro Ile Tyr Phe Ile Thr Gln Leu Pro 20 25 30 Phe Cys Gly Pro Asn Thr Ile Asp His Phe Val Cys Asp Pro Gly Pro 35 40 45 Leu Leu Ala Leu Ser Cys Ile Pro Ala Pro Gly Ile Glu Leu Ser Cys 50 55 60 Ser Ile Leu Ser Ser Leu Ile Ile Phe Ile Ser Phe Phe Phe Ile Leu 65 70 75 80 Ala Ser Tyr Thr Leu Val Leu Arg Ala Val Leu Arg Val Pro Ser Ala 85 90 95

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Ala Gly Arg Arg 100 Lys Ala Phe Ser Thr Cys Gly Ser 105 His Leu 110 Thr Val Val Ser Leu Phe Tyr Gly Ser Ile Met Val Met Tyr Ile Ser Pro Thr 115 120 125 Ser Gly Asn Ala Ala Gly Ile Gln Lys Ile Val Thr Leu Phe Tyr Ser 130 135 140 Ser Val Thr Pro Leu Ile Asn Pro Leu Ile Tyr Ser Leu Arg Asn Asn 145 150 155 160 Asp Val Lys Ala Ala Leu Arg Lys Ile His Met Cys Thr Lys Ile Ser 165 170 175

Gln Ser Lys <210> 2659 <211> 947 <212> DNA <213> Felis catus <400> 2659

atgaacaggt cagcaacaca cattcacctt gtgactgagt ttattctcct ggggttccct 60 ggttgctggg agatacagat tttcctcttc tcactctttt tggtggctta tgtcttgacg 120 ctgctgggga atggaactat tatctgcgca ataagatggg acccacgact gcatacccca 180 atgtactttc tgctgggaaa ttttgccttc cttgagatct ggtatgcttc atccacagtt 240 cctaacatgt tagccaacat tctctccaaa accaagacca tttcattttc tgcctgcttc 300 ctccagttct acttcttctt ttccctgggc acaactgaat gtctcttcct ggcagtcatg 360 gcttatgatc ggtacctggc catctgccac ccactgcact accccaccat catgactggg 420 aaactctgta gaattctggt gtctctctgc tggcttactg gattccttgg ctacccaatc 480 cccattttct tcatctccca actccccttc tgtggatcca atatcattga tcatttcctg 540 tgtgatatgg atccactgat gtctctgtct tgtgctccag cccccattac tgaatttgtt 600

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ttctatactc agagctccct tgttctcttt tttactatta tgtacattct tcgatcctat 660 accctgttgc tcagagctgt ttttcaggtc ccttctgcag ctggccggag aaaggctttt 720 gccacctgtg gttctcattt agttgtggtg tctctttttt atgggacagt catggtaatg 780 tatgagtcct acatatggca tcccaacttt gatgcagaag atcctgacag tggcatattc 840 aataatgact cctctcttta atcccctgat ttacagtctt cgtaataagg acatgaaact 900 tgccctgaga aatatcctgt ttagaatgag aattagtcaa aattctt 947 <210> 2660 <211> 286 <212> PRT <213> Felis catus <400> 2660 Met Asn Arg Ser Ala Thr His Ile His Leu Val Thr Glu Phe Ile Leu 1 5 10 15 Leu Gly Phe Pro Gly Cys Trp Glu Ile Gln Ile Phe Leu Phe Ser Leu 20 25 30 Phe Leu Val Ala Tyr Val Leu Thr Leu Leu Gly Asn Gly Thr Ile Ile 35 40 45 Cys Ala Ile Arg Trp Asp Pro Arg Leu His Thr Pro Met Tyr Phe Leu 50 55 60 Leu Gly Asn Phe Ala Phe Leu Glu Ile Trp Tyr Ala Ser Ser Thr Val 65 70 75 80 Pro Asn Met Leu Ala Asn Ile Leu Ser Lys Thr Lys Thr Ile Ser Phe 85 90 95 Ser Ala Cys Phe Leu Gln Phe Tyr Phe Phe Phe Ser Leu Gly Thr Thr 100 105 110 Glu Cys Leu Phe Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile 115 120 125 Cys His Pro Leu His Tyr Pro Thr Ile Met Thr Gly Lys Leu Cys Arg

Page 2957

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130 135 140

Ile 145 Leu Val Ser Leu Cys Trp Leu Thr Gly Phe Leu Gly Tyr Pro Ile 150 155 160 Pro Ile Phe Phe Ile Ser Gln Leu Pro Phe Cys Gly Ser Asn Ile Ile 165 170 175 Asp His Phe Leu Cys Asp Met Asp Pro Leu Met Ser Leu Ser Cys Ala 180 185 190 Pro Ala Pro Ile Thr Glu Phe Val Phe Tyr Thr Gln Ser Ser Leu Val 195 200 205 Leu Phe Phe Thr Ile Met Tyr Ile Leu Arg Ser Tyr Thr Leu Leu Leu 210 215 220 Arg Ala Val Phe Gln Val Pro Ser Ala Ala Gly Arg Arg Lys Ala Phe 225 230 235 240 Ala Thr Cys Gly Ser His Leu Val Val Val Ser Leu Phe Tyr Gly Thr 245 250 255 Val Met Val Met Tyr Glu Ser Tyr Ile Trp His Pro Asn Phe Asp Ala 260 265 270 Glu Asp Pro Asp Ser Gly Ile Phe Asn Asn Asp Ser Ser Leu 275 280 285

<210> 2661 <211> 995 <212> DNA <213> Felis catus <400> 2661 tcacttcact ccttcctact gaaactctta ggtagcaaaa gttcccccca aaagcccgct accactttcc taaacatatc tttcaaagct tccttgactt gctcattgcg taaggcatag atgaatggat tcatcagtgg tgtcacaaat gttgttacca ctgtcactgc ccagttagta tccacagagc cactctgtga tggtcgcaca taaagaaaaa tggcacttcc atagaagagg

120

180

240

Page 2958

069269_0225_SL.TXT

gtcaccacca tcaagtggga ggtacaggta gagaaggccc tctgtcggcc tgaaacagag 300 gggatgcgca ggacagccag aactatgtga ccataggaca cagcagtaat catcagtgag 360 gatacaatga cgagaaaggc cagtacaaag tctgttttct ccagcttctc ggtgtcggtg 420 catgccaggc ggagcagtgg accactgtca cagaagaagt gctgcaccat ggcgtcctgt 480 tcacagaaag gaagtaaggc cacagccact gtggggccaa gcacagggaa aagtcccccc 540 atccagcagg ccaaggccac ccgaaagcac acagtgccat tcatgagcaa ggggtagtgc 600 agagggtgac agatggccag gtagcgatcc acagacatgg cagccaacag caggaactct 660 gaggccccaa gaaagaagta gaaatagaac tgggcaatac atgcagcaaa ggaaatagtg 720 tgttgccttg ataggaaatt gctcagcatc ttgggaatga tgacagaagt gagcaagatt 780 tctaggcagg acaagttacc cagaaagaag tacataggag tctgcaggcg agtgtcagct 840 cctaccactc caacaatcaa cacgttgcct gttagagtca gcagatagac gagaaggaag 900 acagaaaaca gttctgcttt tgtgctgttg agatttggga aacctgccag gatgaactct 960 gtaacaccaa tgctctggtt ccccccagga gccat 995

<210> 2662 <211> 329 <212> PRT <213> Felis catus

<400> 2662 Met Ala Pro Gly 1 Gly 5 Asn Gln Ser Ile Gly Val Thr Glu Phe Ile Leu 10 15 Ala Gly Phe Pro Asn Leu Asn Ser Thr Lys Ala Glu Leu Phe Ser Val 20 25 30 Phe Leu Leu Val Tyr Leu Leu Thr Leu Thr Gly Asn Val Leu Ile Val 35 40 45 Gly Val Val Gly Ala Asp Thr Arg Leu Gln Thr Pro Met Tyr Phe Phe 50 55 60 Leu Gly Asn Leu Ser Cys Leu Glu Ile Leu Leu Thr Ser Val Ile Ile 65 70 75 80

Page 2959

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Pro Lys Met Leu Ser Asn Phe Leu Ser Arg Gln His Thr Ile Ser Phe 85 90 95 Ala Ala Cys Ile Ala Gln Phe Tyr Phe Tyr Phe Phe Leu Gly Ala Ser 100 105 110 Glu Phe Leu Leu Leu Ala Ala Met Ser Val Asp Arg Tyr Leu Ala Ile 115 120 125 Cys His Pro Leu His Tyr Pro Leu Leu Met Asn Gly Thr Val Cys Phe 130 135 140 Arg Val Ala Leu Ala Cys Trp Met Gly Gly Leu Phe Pro Val Leu Gly 145 150 155 160 Pro Thr Val Ala Val Ala Leu Leu Pro Phe Cys Glu Gln Asp Ala Met 165 170 175 Val Gln His Phe Phe Cys Asp Ser Gly Pro Leu Leu Arg Leu Ala Cys 180 185 190 Thr Asp Thr Glu Lys Leu Glu Lys Thr Asp Phe Val Leu Ala Phe Leu 195 200 205 Val Ile Val Ser Ser Leu Met Ile Thr Ala Val Ser Tyr Gly His Ile 210 215 220 Val Leu Ala Val Leu Arg Ile Pro Ser Val Ser Gly Arg Gln Arg Ala 225 230 235 240 Phe Ser Thr Cys Thr Ser His Leu Met Val Val Thr Leu Phe Tyr Gly 245 250 255 Ser Ala Ile Phe Leu Tyr Val Arg Pro Ser Gln Ser Gly Ser Val Asp 260 265 270 Thr Asn Trp Ala Val Thr Val Val Thr Thr Phe Val Thr Pro Leu Met 275 280 285

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Asn Pro Phe Ile Tyr Ala Leu Arg Asn Glu Gln Val Lys Glu Ala Leu 290 295 300 Lys Asp Met Phe Arg Lys Val Val Ala Gly Phe Trp Gly Glu Leu Leu 305 310 315 320 Leu Pro Lys Ser Phe Ser Arg Lys Glu

325 <210> 2663 <211> 939 <212> DNA <213> Felis catus <400> 2663

atggatgctc taaatcaaac aagagtgact gaatttgtct tcttgggact cactgataag 60 tgggtgctgg agatactatt ttttctggca ttctccgtca catatgtatt aacccttttg 120 ggaaacactc tcattatagt tactatagtc tttactccac gcctccatac ccccatgtat 180 ttcttcctga gcaatctgtc ctttattgac atctgccact catctgtcac tgtgcccaag 240 atgctagagg gcttgctttt agagataaag actatttcct ttgataattg cattgcacag 300 ctcttcttcc tacatctgtt tgcttgtgct gagatctttc tgctgaccat tatggcttat 360 gatcgttatg tagccatctg tgctccattg cactattcta atgtgatgaa catgagggtc 420 tgtgtacagc ttgtctttgc tctctggttg ggggctactg ttcactctct ggtgcagacc 480 ttcttgacca ttcgtctacc ttactgtggc cccaacatta ttgatagcta cttctgcgat 540 gtgccccctg tcatcaagct ggcttgcaca gatacatacc tcacgggaat gctaattgtg 600 tctaatagtg gaaccatctc cctcacctgt ttcctggctt tggtcacctc ttacacggtc 660 atcctggttt ctcttagaaa acagtcagct gaagggcgcc ggaaagcctt gtctacctgt 720 tcagcccact tcatggttgt agccttcttt tttggaccat gtatcttcat ctacactcgg 780 ccagacacta gcttctccat tgacaaggtg gtatctgtct tctacacagt ggtcactcct 840 ttgctgaatc ctctcattta caccttgaga aatgaggagg taaaaagtgc catgaagcat 900 ctcagacaga gaggtttttt catgaagtca ggtacatga 939

Page 2961

069269_0225_SL.TXT <210> 2664 <211> 312 <212> PRT <213> Felis catus

<400> 2664 Phe Val Phe Leu 15 Gly Met 1 Asp Ala Leu Asn Gln 5 Thr Arg Val Thr 10 Glu Leu Thr Asp Lys Trp Val Leu Glu Ile Leu Phe Phe Leu Ala Phe Ser 20 25 30 Val Thr Tyr Val Leu Thr Leu Leu Gly Asn Thr Leu Ile Ile Val Thr 35 40 45 Ile Val Phe Thr Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Ile Cys His Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Gly Leu Leu Leu Glu Ile Lys Thr Ile Ser Phe Asp Asn 85 90 95 Cys Ile Ala Gln Leu Phe Phe Leu His Leu Phe Ala Cys Ala Glu Ile 100 105 110 Phe Leu Leu Thr Ile Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ala 115 120 125 Pro Leu His Tyr Ser Asn Val Met Asn Met Arg Val Cys Val Gln Leu 130 135 140 Val Phe Ala Leu Trp Leu Gly Ala Thr Val His Ser Leu Val Gln Thr 145 150 155 160 Phe Leu Thr Ile Arg Leu Pro Tyr Cys Gly Pro Asn Ile Ile Asp Ser 165 170 175 Tyr Phe Cys Asp Val Pro Pro Val Ile Lys Leu Ala Cys Thr Asp Thr

Page 2962

180

069269_0225_SL.TXT 185 190

Tyr Leu Thr Gly Met Leu Ile Val 200 Ser Asn Ser Gly Thr 205 Ile Ser Leu 195 Thr Cys Phe Leu Ala Leu Val Thr Ser Tyr Thr Val Ile Leu Val Ser 210 215 220 Leu Arg Lys Gln Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys 225 230 235 240 Ser Ala His Phe Met Val Val Ala Phe Phe Phe Gly Pro Cys Ile Phe 245 250 255 Ile Tyr Thr Arg Pro Asp Thr Ser Phe Ser Ile Asp Lys Val Val Ser 260 265 270 Val Phe Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr 275 280 285 Leu Arg Asn Glu Glu Val Lys Ser Ala Met Lys His Leu Arg Gln Arg 290 295 300 Gly Phe Phe Met Lys Ser Gly Thr

305 310 <210> 2665 <211> 938 <212> DNA <213> Felis catus <400> 2665

cctctcccct ccaaccttcc cattaacttg ttcaaggcat ttttcatgtc ttcattccta 60 agagtataga tgatggggtt cagcaggggg gtgacagcgg tgaaaaacac agccaccacc 120 ttgtcctcag ggaggctggt ggatggacgg gaatagatga agatgcagtg gcccaggaat 180 aatgtgacca cggtgaggtg ggctgcacag gtggataagg ccttccgcct gccttcggac 240 agctgctgcc gcaggctaac caggatgact gcataggaca ccacaaggac cacgaaacag 300 accacagaga tcagcccact gttggagatg atgaggattt caatgatgtg ggtatccgtg Page 2963 360

069269_0225_SL.TXT

caggccaatt tgatcacctg aggtacatcg cagaagaagt tgtcgatctc atcgggacca 420 cagtagggca gcttgatggt gagggaggtc agtgcgacgg agtggatggt tcctcctgtc 480 cagagggcca cagcaagaag cacacatact ttccagttca taactgtcat gtactgcagg 540 ggtttgcaaa tggccacata ccgatcatag gccatgatgg tgaggagaaa gatctctgtg 600 caggcaaaga ggtgcaggaa aaacatctga gtgacacagg catcaaagga gatgagcttc 660 tcttctgacc atgtatctat cagcatcttg gggactgtga cagtggagtg gcagacatcg 720 ataaaagaca ggttgctgag gaagaaatac ataggggtat ggagccggcg gtcataggta 780 atagttatga caatgaggat gttcccaatc agtgtcagga catagaaagt gaggaacatg 840 gcaaacacag ccatctgcac cttctgattt acagataagc ctctaagtcg tatatatgtg 900 atggaagagg tttgattgag taggccggcc tcttccat 938

<210> 2666 <211> 313 <212> PRT <213> Felis catus <400> 2666

Met Glu Glu Ala Gly Leu Leu Asn Gln Thr Ser Ser Ile Thr Tyr Ile 1 5 10 15 Arg Leu Arg Gly Leu Ser Val Asn Gln Lys Val Gln Met Ala Val Phe 20 25 30 Ala Met Phe Leu Thr Phe Tyr Val Leu Thr Leu Ile Gly Asn Ile Leu 35 40 45 Ile Val Ile Thr Ile Thr Tyr Asp Arg Arg Leu His Thr Pro Met Tyr 50 55 60 Phe Phe Leu Ser Asn Leu Ser Phe Ile Asp Val Cys His Ser Thr Val 65 70 75 80 Thr Val Pro Lys Met Leu Ile Asp Thr Trp Ser Glu Glu Lys Leu Ile 85 90 95

Page 2964

Ser Phe Asp Ala 100 Cys Val Thr 069269_0225_SL.TXT Gln Met Phe Phe Leu His 105 Leu 110 Phe Ala Cys Thr Glu Ile Phe Leu Leu Thr Ile Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys Lys Pro Leu Gln Tyr Met Thr Val Met Asn Trp Lys Val 130 135 140 Cys Val Leu Leu Ala Val Ala Leu Trp Thr Gly Gly Thr Ile His Ser 145 150 155 160 Val Ala Leu Thr Ser Leu Thr Ile Lys Leu Pro Tyr Cys Gly Pro Asp 165 170 175 Glu Ile Asp Asn Phe Phe Cys Asp Val Pro Gln Val Ile Lys Leu Ala 180 185 190 Cys Thr Asp Thr His Ile Ile Glu Ile Leu Ile Ile Ser Asn Ser Gly 195 200 205 Leu Ile Ser Val Val Cys Phe Val Val Leu Val Val Ser Tyr Ala Val 210 215 220 Ile Leu Val Ser Leu Arg Gln Gln Leu Ser Glu Gly Arg Arg Lys Ala 225 230 235 240 Leu Ser Thr Cys Ala Ala His Leu Thr Val Val Thr Leu Phe Leu Gly 245 250 255 His Cys Ile Phe Ile Tyr Ser Arg Pro Ser Thr Ser Leu Pro Glu Asp 260 265 270 Lys Val Val Ala Val Phe Phe Thr Ala Val Thr Pro Leu Leu Asn Pro 275 280 285 Ile Ile Tyr Thr Leu Arg Asn Glu Asp Met Lys Asn Ala Leu Asn Lys 290 295 300

Page 2965

069269_0225_SL.TXT Leu Met Gly Arg Leu Glu Gly Arg Gly 305 310 <210> 2667 <211> 924 <212> DNA <213> Felis catus <400> 2667

atgaggaacc acaccactgt caccgagttt gtcctgctgg gactctcaga tgcctgtgag 60 ttgcagatgc tcatcttcct ggggctgctg ctgacctacc tcctcactct gctggggaat 120 ctcctcatcg tgggcatcac cctcgtggac aggcgcctcc acacccccat gtactacttc 180 ctccgcaact ttgctgtcct ggagatctgg ttcacctcgg tcatcttccc caagatgctg 240 accaacatcc tgactggata caagaccatc tctctcccag gctgtttcct acaaagtttc 300 ctctatttct ccctgggcac cacagagttc ttcctactgg cagtgatgtc ctttgacagg 360 tatgtggcca tatgtaaccc cttgcgttat gcaaccatca tgagcaaaaa ggtctgtgtg 420 aagtcagttc tttgttcatg gatggcagga ttccttctca ttgtctttcc aagttccatc 480 acttttcagc agccattttg tggccccaac gtcattaacc atttcttttg tgacaacttt 540 ccactcctgg aactgatatg tgcagacacg agtctgatag agcttctggg ttttattgtg 600 gccaacctca gtttgctggg cactctgtcc gtgacggcca cctgctacgg ccacatcctc 660 cacaccatcc tgcgcatccc ctcggccaag gagagacaga aagccttctc aacctgctcc 720 tcccacatca ttgttgtgtc tctcttctat ggcagctgca tcttcatgta catccggtca 780 ggcaagggaa atgaggggga ggacaggaac aaggtggtgg ccttgctcaa caccgtggtg 840 accccgatgc tcaatccctt catctacacc ctgcggaaca agcaggtgaa gcaggtgttt 900 aaggagcagg taaacaagct cttc 924

<210> 2668 <211> 308 <212> PRT <213> Felis catus <400> 2668

Met Arg Asn His Thr Thr Val Thr Glu Phe Val Leu Leu Gly Leu Ser 1 5 10 15

Page 2966

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Asp Ala Cys Glu 20 Leu Gln Met Leu Ile Phe Leu Gly Leu Leu Leu Thr 25 30 Tyr Leu Leu Thr Leu Leu Gly Asn Leu Leu Ile Val Gly Ile Thr Leu 35 40 45 Val Asp Arg Arg Leu His Thr Pro Met Tyr Tyr Phe Leu Arg Asn Phe 50 55 60 Ala Val Leu Glu Ile Trp Phe Thr Ser Val Ile Phe Pro Lys Met Leu 65 70 75 80 Thr Asn Ile Leu Thr Gly Tyr Lys Thr Ile Ser Leu Pro Gly Cys Phe 85 90 95 Leu Gln Ser Phe Leu Tyr Phe Ser Leu Gly Thr Thr Glu Phe Phe Leu 100 105 110 Leu Ala Val Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 115 120 125 Arg Tyr Ala Thr Ile Met Ser Lys Lys Val Cys Val Lys Ser Val Leu 130 135 140 Cys Ser Trp Met Ala Gly Phe Leu Leu Ile Val Phe Pro Ser Ser Ile 145 150 155 160 Thr Phe Gln Gln Pro Phe Cys Gly Pro Asn Val Ile Asn His Phe Phe 165 170 175 Cys Asp Asn Phe Pro Leu Leu Glu Leu Ile Cys Ala Asp Thr Ser Leu 180 185 190 Ile Glu Leu Leu Gly Phe Ile Val Ala Asn Leu Ser Leu Leu Gly Thr 195 200 205 Leu Ser Val Thr Ala Thr Cys Tyr Gly His Ile Leu His Thr Ile Leu 210 215 220

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Arg Ile 225 Pro Ser Ala Lys Glu 230 Arg Gln Lys Ala Phe Ser Thr Cys Ser 235 240 Ser His Ile Ile Val Val Ser Leu Phe Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Arg Ser Gly Lys Gly Asn Glu Gly Glu Asp Arg Asn Lys Val 260 265 270 Val Ala Leu Leu Asn Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Gln Val Lys Gln Val Phe Lys Glu Gln Val 290 295 300

Asn Lys Leu Phe 305 <210> 2669 <211> 957 <212> DNA <213> Felis catus <400> 2669

tcaaatttat tgcatctttc tggtcaaaag caatctcttt cttgttagaa cttttctgaa 60 agctttcttc acatctttgt ttctcagggt gtatatgaga gggtttacca atggagtgac 120 cacacagtag aacactgaga tcactttacc aatagtgaag ttgtgtgtgg ctggagggcg 180 aacataagca aagataatgg tgccataata aatggtgacc acagtgaggt gggaggcaca 240 tgtggaaaaa gctttcctct gagctttttg ggaagacagc ttgattattg tgaccacaat 300 gtatccatag gaaaacatag tgagaaggaa agaacttaga atcacaacag atgtacatgt 360 gtagcccaag gcctccacca aaaatgtatc agagcaagac agtttaaaaa tggggtctga 420 gtcacaaaag aaatggttga tcttctgggg gccacagaag cttagatggg agatgagtat 480 agtaggtagc agaggggcaa tgaagccccc aatccatgat ccagctgaaa accgcaggca 540 cacccgaaga ctcatgagaa gtgaatacct taaagggctg cagatggcca ggtaccggtc 600 ataggccatc actgcgagca ggatgcactc tgtagctccc atggagaaaa agaagagtac 660

Page 2968

069269_0225_SL.TXT tggtatacaa ccaaaaacag agatggtaac aacccgtgcg aggcaggtgg ccagcaactt aggcaccgtg gctgtggtgt accagatctc caggaatgac aaatttccta aaaaaatgta catgggtgtt tggagtgtga catccgtgag aacaatgaaa ataataagag tgtttcccat gagggagagc agatacacag tgagaaatat cacaaacaaa gttagccgca gatagagaac actagaaaac ccaagaaaaa tgaactctgt cactgctgtt tggtttgttc catccat

720

780

840

900

957 <210> 2670 <211> 316 <212> PRT <213> Felis catus

<400> 2670 Thr Asn 5 Gln Thr Ala Val Thr Glu Phe Ile Phe Leu Gly Met 1 Asp Gly 10 15 Phe Ser Ser Val Leu Tyr Leu Arg Leu Thr Leu Phe Val Ile Phe Leu 20 25 30 Thr Val Tyr Leu Leu Ser Leu Met Gly Asn Thr Leu Ile Ile Phe Ile 35 40 45 Val Leu Thr Asp Val Thr Leu Gln Thr Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Val Pro Lys 65 70 75 80 Leu Leu Ala Thr Cys Leu Ala Arg Val Val Thr Ile Ser Val Phe Gly 85 90 95 Cys Ile Pro Val Leu Phe Phe Phe Ser Met Gly Ala Thr Glu Cys Ile 100 105 110 Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Ser Pro 115 120 125 Leu Arg Tyr Ser Leu Leu Met Ser Leu Arg Val Cys Leu Arg Phe Ser 130 135 140

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Ala 145 Gly Ser Trp Ile Gly Gly Phe Ile Ala Pro Leu Leu Pro Thr Ile 150 155 160 Leu Ile Ser His Leu Ser Phe Cys Gly Pro Gln Lys Ile Asn His Phe 165 170 175 Phe Cys Asp Ser Asp Pro Ile Phe Lys Leu Ser Cys Ser Asp Thr Phe 180 185 190 Leu Val Glu Ala Leu Gly Tyr Thr Cys Thr Ser Val Val Ile Leu Ser 195 200 205 Ser Phe Leu Leu Thr Met Phe Ser Tyr Gly Tyr Ile Val Val Thr Ile 210 215 220 Ile Lys Leu Ser Ser Gln Lys Ala Gln Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ser His Leu Thr Val Val Thr Ile Tyr Tyr Gly Thr Ile Ile Phe 245 250 255 Ala Tyr Val Arg Pro Pro Ala Thr His Asn Phe Thr Ile Gly Lys Val 260 265 270 Ile Ser Val Phe Tyr Cys Val Val Thr Pro Leu Val Asn Pro Leu Ile 275 280 285 Tyr Thr Leu Arg Asn Lys Asp Val Lys Lys Ala Phe Arg Lys Val Leu 290 295 300 Thr Arg Lys Arg Leu Leu Leu Thr Arg Lys Met Gln

305 310 315 <210> 2671 <211> 1047 <212> DNA <213> Felis catus <400> 2671

Page 2970

069269_0225_SL.TXT ctagatagat tctgcctggg ccaggctggt cctcccaagg gccctcacca tggccccctt 60 catttccttg tttcgaaaac tatagatgat ggggttgcac atgggggtga tgatggtgta 120 gagaagggag aaaggcttgt ctttgtcagg gccatgtgtg ctgcgaggat tcatgtaaga 180 gaacatggct gaggtataga gaaagatgac cacagtcaga tgggaggcac aagtagagaa 240 ggtcttcccc cgacctgagg aagaggttct gccaaggatg gaggccagga tgcgggcgta 300 ggagataaca atgagcacca tggggctgag cagcaccacg atggcatcgg caaagatcat 360 tttcaggcta aactgggggt ctccacaaga gagggcaatc actatggggg cctcacagaa 420 gaagttttct atgtggttgt ctctgcagaa gggattccgg aatgacatat actcaagaaa 480 gatgccattg atcagcccaa agaaccaggc agtactcacc agcctcacac agacatgctg 540 gctcatgatc tgggcataat tgagtgggtg gcagatagca atgtaacggt cataggccat 600 aaaagccaag aggacgcact cggctacacc cacacagaag accaggtaca tctgggtcaa 660 gcaagagaca aaggagacag tgtggttctt gaccaccagg tggattagca tctgtgggat 720 ggtggtggtg atgaagcaga catccaggaa ggacagatgg ccaaggaaga agtacatggg 780 gctgttgagt ctggggtctg tccaggtgat gaagatgatg aggccattca tggccatggc 840 aaggctgtag agggctagga agagggcaaa gagcaatgcc cgagtggaag aggagctctg 900 ctcgaagccc acgaggataa actctgtcac tgtgctccca ttccttaggt ccaccatctg 960 cggcctgctt aaggagggag gacaggaaaa gcacaggtga gatagttgta ggggaatgca 1020 aggtactcac ttgggcccag aaaccca 1047 <210> 2672 <211> 318 <212> PRT <213> Felis catus <400> 2672

Met Val Asp Leu Arg Asn Gly Ser Thr Val Thr Glu Phe Ile Leu Val 1 5 10 15

Gly Phe Glu Gln Ser Ser Ser Ser Thr Arg Ala Leu Leu Phe Ala Leu 20 25 30

Phe Leu Ala Leu Tyr Ser Leu Ala Met Ala Met Asn Gly Leu Ile Ile Page 2971

069269_0225_SL.TXT 40 45

Phe Ile Thr Trp Thr Asp Pro Arg Leu Asn Ser Pro Met Tyr Phe Phe 50 55 60 Leu Gly His Leu Ser Phe Leu Asp Val Cys Phe Ile Thr Thr Thr Ile 65 70 75 80 Pro Gln Met Leu Ile His Leu Val Val Lys Asn His Thr Val Ser Phe 85 90 95 Val Ser Cys Leu Thr Gln Met Tyr Leu Val Phe Cys Val Gly Val Ala 100 105 110 Glu Cys Val Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Ile Ala Ile 115 120 125 Cys His Pro Leu Asn Tyr Ala Gln Ile Met Ser Gln His Val Cys Val 130 135 140 Arg Leu Val Ser Thr Ala Trp Phe Phe Gly Leu Ile Asn Gly Ile Phe 145 150 155 160 Leu Glu Tyr Met Ser Phe Arg Asn Pro Phe Cys Arg Asp Asn His Ile 165 170 175 Glu Asn Phe Phe Cys Glu Ala Pro Ile Val Ile Ala Leu Ser Cys Gly 180 185 190 Asp Pro Gln Phe Ser Leu Lys Met Ile Phe Ala Asp Ala Ile Val Val 195 200 205 Leu Leu Ser Pro Met Val Leu Ile Val Ile Ser Tyr Ala Arg Ile Leu 210 215 220 Ala Ser Ile Leu Gly Arg Thr Ser Ser Ser Gly Arg Gly Lys Thr Phe 225 230 235 240 Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Phe Leu Tyr Thr Ser

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245 250 255

Ala Met Phe Ser Tyr Met Asn Pro Arg 265 Ser Thr His Gly Pro 270 Asp Lys 260 Asp Lys Pro Phe Ser Leu Leu Tyr Thr Ile Ile Thr Pro Met Cys Asn 275 280 285 Pro Ile Ile Tyr Ser Phe Arg Asn Lys Glu Met Lys Gly Ala Met Val 290 295 300 Arg Ala Leu Gly Arg Thr Ser Leu Ala Gln Ala Glu Ser Ile 305 310 315

<210> 2673 <211> 1006 <212> DNA <213> Felis catus <220>

<221> modified_base <222> (84)..(103) <223> a, c, t, g, unknown or other <400> 2673

ctagatagat tctgcctggg ccaggctggt cctcccaagg gccctcacca tggccccctt 60 catttccttg tttcggaaac tatnnnnnnn nnnnnnnnnn nnncatgggg gtgatgatgg 120 tgtagagaag ggagaaaggc ttgtctttgt cagggccatg tgtgctgcga ggattcatgt 180 aagagaacat ggctgaggta tagaaaaaga tgaccacagt cagatgggag gcacaagtag 240 agaaggtctt cccccgacct gaggaggagg ttctgccaag gatggaggcc aggatgcggg 300 cgtaggagat aacaatgagc accatggggc tgagcagcac cacgatggca tcggcaaaga 360 tcattttcag gctaaactgg gggtctccac aagagagggc aatcactatg ggggcctcac 420 agaagaagtt ttctatgtgg ttgtctctgc agaatggacc acgaaatgtc atataatcaa 480 gcagaatgcc attgatcagc ccaaagaacc aggcagtact caccagcttt acacagacct 540 gccggctcat gatctgtgca tagctgagtg ggtggcagat agcaacgtaa cggtcatagg 600 ccataaaagc caagaggatg cactcggcca cacctacacc aaaaaccaga tacatctggg 660

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tcaagcagga ggcaaaggag acagtgtggt tcttgaccac caggtggatt agcatctgtg 720 ggatggtggt ggtgatgaag cagacatcca ggaaggacag atggccaagg aagaagtaca 780 tggggctgtt gagtctgggg tctgtccagg tgatgaagat gatgaggcca ttcatggcca 840 tggcaaggct gtagagggct aggaagaggg caaagagcaa tgcccgagtg gaagaggagc 900 tctgctcgaa gcccacgagg ataaactctg tcactgtgct cccattcctt aggtccacca 960 tctgcggcct gcttgaggag ggaagacagg aaaagcacag gtgaga 1006

<210> 2674 <211> 308 <212> PRT <213> Felis catus <220>

<221> MOD RES

<222> (302)..(308) Cys Leu Pro Ser 10 Ser Ser Arg Pro Gln 15 Met <223> Any amino <400> 2674 acid Phe Ser 5 Ser His 1 Leu Cys Val Asp Leu Arg Asn Gly Ser Thr Val Thr Glu Phe Ile Leu Val Gly 20 25 30 Phe Glu Gln Ser Ser Ser Ser Thr Arg Ala Leu Leu Phe Ala Leu Phe 35 40 45 Leu Ala Leu Tyr Ser Leu Ala Met Ala Met Asn Gly Leu Ile Ile Phe 50 55 60 Ile Thr Trp Thr Asp Pro Arg Leu Asn Ser Pro Met Tyr Phe Phe Leu 65 70 75 80 Gly His Leu Ser Phe Leu Asp Val Cys Phe Ile Thr Thr Thr Ile Pro 85 90 95 Gln Met Leu Ile His Leu Val Val Lys Asn His Thr Val Ser Phe Ala 100 105 110

Page 2974

069269_0225_SL.TXT

Ser Cys Leu 115 Thr Gln Met Tyr Leu Val Phe Gly Val Gly Val Ala Glu 120 125 Cys Ile Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 130 135 140 His Pro Leu Ser Tyr Ala Gln Ile Met Ser Arg Gln Val Cys Val Lys 145 150 155 160 Leu Val Ser Thr Ala Trp Phe Phe Gly Leu Ile Asn Gly Ile Leu Leu 165 170 175 Asp Tyr Met Thr Phe Arg Gly Pro Phe Cys Arg Asp Asn His Ile Glu 180 185 190 Asn Phe Phe Cys Glu Ala Pro Ile Val Ile Ala Leu Ser Cys Gly Asp 195 200 205 Pro Gln Phe Ser Leu Lys Met Ile Phe Ala Asp Ala Ile Val Val Leu 210 215 220 Leu Ser Pro Met Val Leu Ile Val Ile Ser Tyr Ala Arg Ile Leu Ala 225 230 235 240 Ser Ile Leu Gly Arg Thr Ser Ser Ser Gly Arg Gly Lys Thr Phe Ser 245 250 255 Thr Cys Ala Ser His Leu Thr Val Val Ile Phe Phe Tyr Thr Ser Ala 260 265 270 Met Phe Ser Tyr Met Asn Pro Arg Ser Thr His Gly Pro Asp Lys Asp 275 280 285 Lys Pro Phe Ser Leu Leu Tyr Thr Ile Ile Thr Pro Met Xaa Xaa Xaa 290 295 300

Xaa Xaa Xaa Xaa 305

Page 2975

069269_0225_SL.TXT <210> 2675 <211> 921 <212> DNA <213> Felis catus <400> 2675

ggcacacttt tgttgcttca gcatcctctg cagagcagcc ttcacctcct ggttcttgag 60 gctgtagatg agggggttca gcaaggatgt gatcacactg tactgaatgg agaccacacg 120 ctccaacact gagcctgaag cagggctgat gtacctgaat agagctgtcc catagaacaa 180 gagcaccacg gtgaggtggg aggagcaggt ggagaaggct ttggcttggc cctcagagga 240 gcggatgttc agaatggcac aaattactct ggagtaagag aagaggatca ggggaagtgt 300 cagcagccct agaaatgcac aggacactgc aagaagaatc tcattgacaa tgggatcggt 360 acaggacaga ggaaagagag gaggtagctc acagctaaag tggaggatga tgttggaccc 420 gcagaaatac aacttgtgga tgaagagact attcagcaag gaaatcagaa atcccactgc 480 ccacgatatg ctcacaatca caatacagag aggtctgttt atgaccatgg tgtagaccag 540 agggtggcag atagcagcat agcggtcata ggccatggca gagagcagac aagcttctgt 600 ccccccagag agagtgaaaa agaagctctg agtgatgcat ccccacattg agatgctttt 660 attctgagtt aagaagttct gtagcatctt gggcacagtg actgaggaga aactgagatc 720 caggaaggat aggtgtccaa ggaagaagta catgggtgtg tggaggcggg gatcaaccct 780 gatcaccagg atcatcacca gattccccac cagggtcagg aggtaaatcc ccaggaacag 840 cacgaagagc atggtctgga tctgggggtc actggataat cccaggagga caaactcagt 900 aatcatactg acatttttca t 921

<210> 2676 <211> 307 <212> PRT <213> Felis catus

<400> 2676 Met Lys Asn Val Ser Met Ile Thr Glu Phe Val Leu Leu Gly Leu Ser 1 5 10 15 Ser Asp Pro Gln Ile Gln Thr Met Leu Phe Val Leu Phe Leu Gly Ile 1 Page 2976

069269_0225_SL.TXT 25 30

Tyr Leu Leu 35 Thr Leu Val Gly Asn Leu Val Met Ile Leu Val Ile Arg 40 45 Val Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly His Leu 50 55 60 Ser Phe Leu Asp Leu Ser Phe Ser Ser Val Thr Val Pro Lys Met Leu 65 70 75 80 Gln Asn Phe Leu Thr Gln Asn Lys Ser Ile Ser Met Trp Gly Cys Ile 85 90 95 Thr Gln Ser Phe Phe Phe Thr Leu Ser Gly Gly Thr Glu Ala Cys Leu 100 105 110 Leu Ser Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His Pro Leu 115 120 125 Val Tyr Thr Met Val Ile Asn Arg Pro Leu Cys Ile Val Ile Val Ser 130 135 140 Ile Ser Trp Ala Val Gly Phe Leu Ile Ser Leu Leu Asn Ser Leu Phe 145 150 155 160 Ile His Lys Leu Tyr Phe Cys Gly Ser Asn Ile Ile Leu His Phe Ser 165 170 175 Cys Glu Leu Pro Pro Leu Phe Pro Leu Ser Cys Thr Asp Pro Ile Val 180 185 190 Asn Glu Ile Leu Leu Ala Val Ser Cys Ala Phe Leu Gly Leu Leu Thr 195 200 205 Leu Pro Leu Ile Leu Phe Ser Tyr Ser Arg Val Ile Cys Ala Ile Leu 210 215 220 Asn Ile Arg Ser Ser Glu Gly Gln Ala Lys Ala Phe Ser Thr Cys Ser

Page 2977

069269_0225_SL.TXT

225 230 235 240 Ser His Leu Thr Val Val Leu Leu Phe Tyr Gly Thr Ala Leu Phe Arg 245 250 255 Tyr Ile Ser Pro Ala Ser Gly Ser Val Leu Glu Arg Val Val Ser Ile 260 265 270 Gln Tyr Ser Val Ile Thr Ser Leu Leu Asn Pro Leu Ile Tyr Ser Leu 275 280 285 Lys Asn Gln Glu Val Lys Ala Ala Leu Gln Arg Met Leu Lys Gln Gln 290 295 300 Lys Cys Ala

305 <210> 2677 <211> 906 <212> DNA <213> Felis catus <400> 2677

ttactgcctc agtatcctct gcagagcagc cttcacctcc tggttcttga ggctgtagat 60 gagggggttc agcaaggatg tgatcacact gtactgaatg gagaccacac gctccaacac 120 tgagcctgag gcagggctga tgtacctgaa tagagccgtc ccatagaaca agagcaccac 180 cgtgagatgg gaggagcagg tggagaaggc tttggcttgg ccctcagagg agcggatgtt 240 cagaatggca gaaatgattc tggagtaaga gaagaggatc aggggaagcg tcagcagccc 300 tagaaatgca ctggaccctg acagaaggaa cttgttggca gtgggatcag tacatgacag 360 agggaagagt gagggcagct cacagcagaa gtggaagatg atgttggacc cacagaaatg 420 taacttgtgg atgaaaagat tatttaccag tgagttcaga acccctattc cccatgctgc 480 gctgaccatt accatgcaga gaggcctgtt catgaccatg gtatagagca gagggtggca 540 gatggcggca tagcggtcat aggccatggc agagagcaga ctggcttccg cacacccaca 600 gagaagaaaa aagaaactct gggtgataca gccccacaca gagatgcttt tcttctgaga 660 caggaagttc tgtagcattt tgggcatagt aactgaagag aagcagatat ctaggaagga 720

Page 2978

069269_0225_SL.TXT cagatgtcca aggaaaaaat acatggggat gtggaggtga gaatcccctc tgatcaccag gatcatcacc agattcccca ccagggtcag gaggtaaatc cccaggaaca ccacaaagag cagagtctgg atgcggcagt cagcagacag cccgaggagg atgaactcag tgaagaaagt gaagtt

780

840

900

906 <210> 2678 <211> 301 <212> PRT <213> Felis catus <400> 2678

Asn Phe Thr 1 Phe Phe Thr Glu Phe 5 Ile Leu Leu Gly Leu Ser Ala Asp 10 15 Cys Arg Ile Gln Thr Leu Leu Phe Val Val Phe Leu Gly Ile Tyr Leu 20 25 30 Leu Thr Leu Val Gly Asn Leu Val Met Ile Leu Val Ile Arg Gly Asp 35 40 45 Ser His Leu His Ile Pro Met Tyr Phe Phe Leu Gly His Leu Ser Phe 50 55 60 Leu Asp Ile Cys Phe Ser Ser Val Thr Met Pro Lys Met Leu Gln Asn 65 70 75 80 Phe Leu Ser Gln Lys Lys Ser Ile Ser Val Trp Gly Cys Ile Thr Gln 85 90 95 Ser Phe Phe Phe Leu Leu Cys Gly Cys Ala Glu Ala Ser Leu Leu Ser 100 105 110 Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His Pro Leu Leu Tyr 115 120 125 Thr Met Val Met Asn Arg Pro Leu Cys Met Val Met Val Ser Ala Ala 130 135 140

Page 2979

069269_0225_SL.TXT

Trp Gly Ile Gly Val Leu Asn Ser Leu Val Asn Asn Leu Phe Ile His 145 150 155 160 Lys Leu His Phe Cys Gly Ser Asn Ile Ile Phe His Phe Cys Cys Glu 165 170 175 Leu Pro Ser Leu Phe Pro Leu Ser Cys Thr Asp Pro Thr Ala Asn Lys 180 185 190 Phe Leu Leu Ser Gly Ser Ser Ala Phe Leu Gly Leu Leu Thr Leu Pro 195 200 205 Leu Ile Leu Phe Ser Tyr Ser Arg Ile Ile Ser Ala Ile Leu Asn Ile 210 215 220 Arg Ser Ser Glu Gly Gln Ala Lys Ala Phe Ser Thr Cys Ser Ser His 225 230 235 240 Leu Thr Val Val Leu Leu Phe Tyr Gly Thr Ala Leu Phe Arg Tyr Ile 245 250 255 Ser Pro Ala Ser Gly Ser Val Leu Glu Arg Val Val Ser Ile Gln Tyr 260 265 270 Ser Val Ile Thr Ser Leu Leu Asn Pro Leu Ile Tyr Ser Leu Lys Asn 275 280 285 Gln Glu Val Lys Ala Ala Leu Gln Arg Ile Leu Arg Gln 290 295 300 <210> 2679 <211> 918 <212> DNA <213> Felis catus <400> 2679 acacatttat tgcttcaaca ttttatacag ' agctgccttc acctcctggt tcttgaggct gtagatgatg gggttcagca aggatgtgat : cacactgtac tgaatggaga ccacttgttc caacttggag ccggagaggg gagtcatgta tctgaataaa gctgtgccat aatacaaaag

120

180

Page 2980

069269_0225_SL.TXT

caccacagta aggtgggaag aacaggtaga gaaggctttg ccttgaccct cagaagaacg 240 tatgcttagg atggcagaga tgattctgga ataagagaag aggatcaggg gaagtgtcac 300 aaatcccaac agtgcacatg acccagcaag aagggcctca ttggcagtag ggtcagtgca 360 ggagagaggg aagagtgaag gcagctcaca gcaaaagtga gggatgatat tggggccaca 420 gaaatgtaag ttgtaagtga aaagactgtt tggcaaggag tttaggaacc ccactgccca 480 tgctgcagtt accatcccaa cacaaaaagg cctattcata accatgctgt agaggagagg 540 gtggcagatg gcagcatagc ggtcatatgc catggcagag agtaggcagg cctctgtgct 600 cccagagaat atgagaaaga aactctgggt cacacagccc cacacagata cggttttctt 660 ctgcattagt aagttctgca gcatcttggg catggttact gaagaaagac agagatctag 720 aaatgacagg tgacctagga agaagtacat gggtgtctta aggtgagaat cagttctgat 780 caccaggatc atcatcacat tccccattag ggtcaagagg taaatcacca gaaatagtgc 840 aaaaaggatg gtctggatct ggggatttct ggacaatccc atgaggacaa actcggtaac 900 gatggtgaga tttttcat 918

<210> 2680 <211> 303 <212> PRT <213> Felis catus <400> 2680

Met 1 Lys Asn Leu Thr Ile 5 Val Thr Glu Phe Val Leu Met Gly Leu Ser 10 15 Arg Asn Pro Gln Ile Gln Thr Ile Leu Phe Ala Leu Phe Leu Val Ile 20 25 30 Tyr Leu Leu Thr Leu Met Gly Asn Val Met Met Ile Leu Val Ile Arg 35 40 45 Thr Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Gly His Leu 50 55 60 Ser Phe Leu Asp Leu Cys Leu Ser Ser Val Thr Met Pro Lys Met Leu 65 70 75 80

Page 2981

069269_0225_SL.TXT

Gln Asn Leu Leu Met 85 Gln Lys Lys Thr Val Ser Val Trp Gly Cys Val 90 95 Thr Gln Ser Phe Phe Leu Ile Phe Ser Gly Ser Thr Glu Ala Cys Leu 100 105 110 Leu Ser Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His Pro Leu 115 120 125 Leu Tyr Ser Met Val Met Asn Arg Pro Phe Cys Val Gly Met Val Thr 130 135 140 Ala Ala Trp Ala Val Gly Phe Leu Asn Ser Leu Pro Asn Ser Leu Phe 145 150 155 160 Thr Tyr Asn Leu His Phe Cys Gly Pro Asn Ile Ile Pro His Phe Cys 165 170 175 Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Thr Asp Pro Thr Ala 180 185 190 Asn Glu Ala Leu Leu Ala Gly Ser Cys Ala Leu Leu Gly Phe Val Thr 195 200 205 Leu Pro Leu Ile Leu Phe Ser Tyr Ser Arg Ile Ile Ser Ala Ile Leu 210 215 220 Ser Ile Arg Ser Ser Glu Gly Gln Gly Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Leu Thr Val Val Leu Leu Tyr Tyr Gly Thr Ala Leu Phe Arg 245 250 255 Tyr Met Thr Pro Leu Ser Gly Ser Lys Leu Glu Gln Val Val Ser Ile 260 265 270 Gln Tyr Ser Val Ile Thr Ser Leu Leu Asn Pro Ile Ile Tyr Ser Leu 275 280 285

Page 2982

069269_0225_SL.TXT

Lys Asn Gln Glu Val Lys Ala Ala Leu Tyr Lys Met Leu Lys Gln 290 295 300 <210> 2681 <211> 921 <212> DNA <213> Felis catus <400> 2681

aaagaattaa catatcttct taatattctt ctcatagctg tcttcacctc cttgttctgt 60 aggctgtaga caagggggtt cagcatggga gtgaccacgc tgtactgcaa ggagggcatc 120 atcgccagac gggagcctga agttggcaag agatagctga ggaaacctga gccatagaac 180 aagatcacag tagtgaggtg agaagagcaa gtagagaagg ccttgcttct gcctgaggtg 240 gagctgatgc tcaggatggt ggagacaatg cgaacatagg aaaaacatca taacgaaggt 300 tccaaagaaa tgcaagacag aggagcacag caggagtgtg aagttggtcg aggtatcaga 360 acaagacaga gggaagagag aagacagctc acagctgaag tggggaagag tctggtcctc 420 gcaatagtct aaattgacag ccaagaggat attaatgaga gcatcaacaa aggccaggcc 480 ccaggaaccc cacaccatcc caacacagag ctggttgctc atcacctggc catagagcag 540 aggggagctg atggctacat agcggtcata ggccatcaca gccagcagac aggcctctgt 600 acccccggtg gcaaacacaa agaaggcctg agccaggcag ctctctacaa agatgacttt 660 gctttcagaa agtagattct ccagcatctt ggggactgta aaagttgggt ggcagaggtc 720 caggaaggac agctgtctca aaaagaagta catgggcatg tgaaggtgag aatcagtcct 780 aatcaccagc agcatcacca ggttccccat cagggtcagg acgtaaatca ccagaaacaa 840 catgaagagc agaatttgag tctgagggtc agcagataac ataaggagga tgaactcact 900 gacaatgctg tggtttctca t 921

<210> 2682 <211> 304 <212> PRT <213> Felis catus <400> 2682

Met Arg Asn His Ser Ile Val Ser Glu Phe Ile Leu Leu Met Leu Ser 1 5 10 15

Page 2983

069269_0225_SL.TXT

Ala Asp Pro Gln Thr Gln 20 Ile Leu Leu Phe 25 Met Leu Phe Leu Val Ile 30 Tyr Val Leu Thr Leu Met Gly Asn Leu Val Met Leu Leu Val Ile Arg 35 40 45 Thr Asp Ser His Leu His Met Pro Met Tyr Phe Phe Leu Arg Gln Leu 50 55 60 Ser Phe Leu Asp Leu Cys His Pro Thr Phe Thr Val Pro Lys Met Leu 65 70 75 80 Glu Asn Leu Leu Ser Glu Ser Lys Val Ile Phe Val Glu Ser Cys Leu 85 90 95 Ala Gln Ala Phe Phe Val Phe Ala Thr Gly Gly Thr Glu Ala Cys Leu 100 105 110 Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser Ser Pro Leu 115 120 125 Leu Tyr Gly Gln Val Met Ser Asn Gln Leu Cys Val Gly Met Val Trp 130 135 140 Gly Ser Trp Gly Leu Ala Phe Val Asp Ala Leu Ile Asn Ile Leu Leu 145 150 155 160 Ala Val Asn Leu Asp Tyr Cys Glu Asp Gln Thr Leu Pro His Phe Ser 165 170 175 Cys Glu Leu Ser Ser Leu Phe Pro Leu Ser Cys Ser Asp Thr Ser Thr 180 185 190 Asn Phe Thr Leu Leu Leu Cys Ser Ser Val Leu His Phe Phe Gly Thr 195 200 205 Phe Val Met Met Phe Phe Leu Cys Ser His Cys Leu His His Pro Glu 210 215 220

Page 2984

069269_0225_SL.TXT

His Gln 225 Leu His Leu Arg Gln 230 Lys Gln Gly Leu Leu Tyr Leu Leu Phe 235 240 Ser Pro His Tyr Cys Asp Leu Val Leu Trp Leu Arg Phe Pro Gln Leu 245 250 255 Ser Leu Ala Asn Phe Arg Leu Pro Ser Gly Asp Asp Ala Leu Leu Ala 260 265 270 Val Gln Arg Gly His Ser His Ala Glu Pro Pro Cys Leu Gln Pro Thr 275 280 285 Glu Gln Gly Gly Glu Asp Ser Tyr Glu Lys Asn Ile Lys Lys Ile Cys 290 295 300

<210> 2683 <211> 936 <212> DNA <213> Felis catus <400> 2683

ctacatgaga gaatgaaaat attttctgaa cattcttccc atagctgcct tcacctcttt 60 gttctgcagg ctgtagacaa gggggttcag catgggagtg accacgctgt actgcaagga 120 gggcatcatc gccagacggg agcctgaagt tggcaagaga tagctgagga aacctgagcc 180 atagaacaag atcacagtag tgaggtgaga agagcaagta gagaaggcct tgcttctgcc 240 tgaggtggag ctgatgctca ggatggtgga gacaatgcga acataggaaa aaacaatcat 300 aacgaaggtt ccaaagaaat gcaagacaga ggagcacagc aggagtgtga agttggtcga 360 ggtatcagaa caagacagag ggaagagaga agacagctca cagctgaagt ggggaagagt 420 ctggtcctcg caatagtcta aattgacagc caagaggata ttaatgagag catcaacaaa 480 ggccaggccc caggaacccc acaccatccc aacacagagc tggttgctca tcacctggcc 540 atagagcaga ggggagctga tggctacata gcggtcatag gccatcacag ccagcagaca 600 ggcctccgtg cccccagtgg caaacacaaa gaaggcctga gccaggcagc tctctacaaa 660 gatggtttta ctttcagaaa gtagattctc cagcatcttg gggactgtga cagatgagtg 720

Page 2985

069269_0225_SL.TXT gcagaggtcc aggaaggaca gttgtcccaa aaagaagtac atgggcatgt ggaggtgaga atcagcccta atcaccagca gcatcaagaa atttcccatc aaagtgaaga gataaatcag aaagaacagc acaaagagta tagcctgaat attggggtca atagatagtc caaggagaat gaactcactg atagcactgt agtttttcat tgccat

780

840

900

936 <210> 2684 <211> 311 <212> PRT <213> Felis catus <400> 2684

Met Ala 1 Met Lys Asn 5 Tyr Ser Ala Ile Ser Glu Phe Ile Leu Leu Gly 10 15 Leu Ser Ile Asp Pro Asn Ile Gln Ala Ile Leu Phe Val Leu Phe Phe 20 25 30 Leu Ile Tyr Leu Phe Thr Leu Met Gly Asn Phe Leu Met Leu Leu Val 35 40 45 Ile Arg Ala Asp Ser His Leu His Met Pro Met Tyr Phe Phe Leu Gly 50 55 60 Gln Leu Ser Phe Leu Asp Leu Cys His Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Asn Leu Leu Ser Glu Ser Lys Thr Ile Phe Val Glu Ser 85 90 95 Cys Leu Ala Gln Ala Phe Phe Val Phe Ala Thr Gly Gly Thr Glu Ala 100 105 110 Cys Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser Ser 115 120 125 Pro Leu Leu Tyr Gly Gln Val Met Ser Asn Gln Leu Cys Val Gly Met 130 135 140 Val Trp Gly Ser Trp Gly Leu Ala Phe Val Asp Ala Leu Ile Asn Ile

Page 2986

069269_0225_SL.TXT

145 150 Glu 170 155 Asp Gln 160 Leu Leu Ala Val Asn 165 Leu Asp Tyr Cys Thr Leu Pro His 175 Phe Ser Cys Glu Leu Ser Ser Leu Phe Pro Leu Ser Cys Ser Asp Thr 180 185 190 Ser Thr Asn Phe Thr Leu Leu Leu Cys Ser Ser Val Leu His Phe Phe 195 200 205 Gly Thr Phe Val Met Ile Val Phe Ser Tyr Val Arg Ile Val Ser Thr 210 215 220 Ile Leu Ser Ile Ser Ser Thr Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Thr Val Ile Leu Phe Tyr Gly Ser Gly Phe 245 250 255 Leu Ser Tyr Leu Leu Pro Thr Ser Gly Ser Arg Leu Ala Met Met Pro 260 265 270 Ser Leu Gln Tyr Ser Val Val Thr Pro Met Leu Asn Pro Leu Val Tyr 275 280 285 Ser Leu Gln Asn Lys Glu Val Lys Ala Ala Met Gly Arg Met Phe Arg 290 295 300 Lys Tyr Phe His Ser Leu Met 305 310 <210> 2685 <211> 918 <212> DNA <213> Felis catus <400> 2685 ctagatacgt tttctcaaaa ttcttctcac agctgccttc acctctttgt tctttaggct atagatgaga ggattcagca taggagtgac cacactgtac tgcaaggaga agattaactc

120

Page 2987

069269_0225_SL.TXT ttgagtggat cctgaatttg gcatgagata gcggagtaat cctgagccat aaaagaagat cactgcagtg aggtgggagg agcaggtgga gaaggccttg tttctgcctg tggtagcatt gatactcagg atggtgaaca aaatgcaaac ataggagaaa aatatcaaga ggaaatttcc aaagaaatgc aggaggctgg aggagagcag ggcagtaaaa cttgcagaca catcagagca agacaaaggg tagagagaag gcagttcaca gctgaagtga tgtatatttt gagccccaca gaaatctaaa ttgagagcta caaggatatt gataagagca tccaaaaaag ccacgctcca tgagccccac accagcccca tacacaattg tctgttcatc atctggccat agagcagagg ggagctgatg gcaacatagc ggtcataggc catgacagtg agtaggcagg attcagtgcc cccagtggca aacacaaaga aggcctgagc caggcagccc tctactgaga tggttttctt ctcagacagg aggttctcca acagcttggg cacagtgaca gaggagtggc agagatccag gaaggacaac tgtcccagga agaagtacat gggggtgtgg aggcaagaat cagccctaat caccagcagc agcatcaggt tccccatcag ggtcaggagg taaataacaa ggaacagtac aaagaggaga acctcgatct gggggtcagc agacagcccg aagaggatga actcagaaac aacactgtgg tttctcat <210> 2686 <211> 305 <212> PRT <213> Felis catus

180

240

300

360

420

480

540

600

660

720

780

840

900

918 <400> 2686

Met Arg Asn His Ser Val Val Ser Glu Phe Ile Leu Phe Gly Leu Ser 1 5 10 15 Ala Asp Pro Gln Ile Glu Val Leu Leu Phe Val Leu Phe Leu Val Ile 20 25 30 Tyr Leu Leu Thr Leu Met Gly Asn Leu Met Leu Leu Leu Val Ile Arg 35 40 45 Ala Asp Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Gly Gln Leu 50 55 60

Page 2988

069269_0225_SL.TXT

Ser Phe 65 Leu Asp Leu Cys His Ser Ser Val Thr Val Pro Lys Leu Leu 80 70 75 Glu Asn Leu Leu Ser Glu Lys Lys Thr Ile Ser Val Glu Gly Cys Leu 85 90 95 Ala Gln Ala Phe Phe Val Phe Ala Thr Gly Gly Thr Glu Ser Cys Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser Ser Pro Leu 115 120 125 Leu Tyr Gly Gln Met Met Asn Arg Gln Leu Cys Met Gly Leu Val Trp 130 135 140 Gly Ser Trp Ser Val Ala Phe Leu Asp Ala Leu Ile Asn Ile Leu Val 145 150 155 160 Ala Leu Asn Leu Asp Phe Cys Gly Ala Gln Asn Ile His His Phe Ser 165 170 175 Cys Glu Leu Pro Ser Leu Tyr Pro Leu Ser Cys Ser Asp Val Ser Ala 180 185 190 Ser Phe Thr Ala Leu Leu Ser Ser Ser Leu Leu His Phe Phe Gly Asn 195 200 205 Phe Leu Leu Ile Phe Phe Ser Tyr Val Cys Ile Leu Phe Thr Ile Leu 210 215 220 Ser Ile Asn Ala Thr Thr Gly Arg Asn Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Leu Thr Ala Val Ile Phe Phe Tyr Gly Ser Gly Leu Leu Arg 245 250 255 Tyr Leu Met Pro Asn Ser Gly Ser Thr Gln Glu Leu Ile Phe Ser Leu 260 265 270

Page 2989

069269_0225_S L.TX T Gln Tyr Ser Val Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu 275 280 285 Lys Asn Lys Glu Val Lys Ala Ala Val Arg Arg Ile Leu Arg Lys Arg 290 295 300

Ile

305 <210> 2687 <211> 916 <212> DNA <213> Felis catus <400> 2687

atggctttgg ggaaccacac caccatcaca gagtttatcc tgcttgaact acctgctgac 60 ccccacattc agactctgct ctttgtgctt ttcttggtga tttatctcct gaccctagta 120 gggaatctga caatgatgct ggtgaccaag gctgattctt acctccacag cctcatgtac 180 ttcttcctaa gtttcctctc tttcttagac ctctgtttcc cttgtcactg tgcccaagat 240 gttggaaaac ctcctttcta agaagaaaac catctcagaa gagggctgcc tggctcaggt 300 cttctttgta tctatcatgg cagggactga agtctgccta ctctcagaga tggcttatga 360 ccactatgtt gccatctgcc acccactgct caatggccag gtgatgagta aacagtggta 420 tttgcagcta gtgtagggtt catggaacct gggcattctg gacacattca ttaatgtccc 480 tttggcaatg aaaatggact tctgtgataa ccataccagc ccacactaca gctgtgagct 540 gccctccctc ttccttctct cttactcaga tatttctaca aacctctttg tcatattctg 600 ctctttcctc ccatatggcc ttgtaacttc cctgtcaatc ttcatctctt atgcccacat 660 tatctccacc atcctgagca tcacctccac ctctggcaga agcaaagctt tttccacctg 720 ctcctccacc ttaccacaat gatcttgttc tatggctcag gtcttcttca ttatttcatt 780 ccaacttcag aatccacccc ccactctgga tctgatctct gcaatatggt gtgatcactc 840 ccatgctgaa tcctctcatc tgcagaccaa aaaatgaggt gaaggatgct ctgcagagaa 900 cactgggaaa gtattt 916

<210> 2688

Page 2990

069269_0225_SL.TXT <211> 86 <212> PRT

<213> Felis catus <400> 2688 Met Ala Leu Gly Asn His Thr Thr Ile Thr Glu Phe Ile Leu Leu Glu 1 5 10 15 Leu Pro Ala Asp Pro His Ile Gln Thr Leu Leu Phe Val Leu Phe Leu 20 25 30 Val Ile Tyr Leu Leu Thr Leu Val Gly Asn Leu Thr Met Met Leu Val 35 40 45 Thr Lys Ala Asp Ser Tyr Leu His Ser Leu Met Tyr Phe Phe Leu Ser 50 55 60 Phe Leu Ser Phe Leu Asp Leu Cys Phe Pro Cys His Cys Ala Gln Asp 65 70 75 80 Val Gly Lys Pro Pro Phe 85 <210> 2689 <211> 926 <212> DNA <213> Felis catus

<400> 2689

atggccttgg ggaaccgcag caccatcact gaattcttcc tcctcgggct gtctgtcaac 60 ccccacatcc aagctctgtt ttttgtgctg ttcctgaata tttaccttct gaccatcatg 120 gggaacctgc tgctgctgct ggtgatcagg gctgactctc acctccacac acccatgtac 180 tttttcctca gtcatctctc tttcctggac ttttgtttat cttcagctac tgtgcccagg 240 atgttgaaag acctcctatc ggagataaaa actatctcag taaggggctg cctggctcaa 300 ggcttctttg tgtttatcac cgcagggact gaagcttttc tgctctcagt gatggcctat 360 gaccgctatg ctgccatctg ccaccctctg ctctatggac agatgatgag aaaacagctg 420 tgtgtgcaac ttgtattggg ctcatggggc ttgagttttt tgaatgcact tattaacatc 480 ctccttgctg ccagcttgga cttctgtgag agccatacca tcaaccacta cagctgtgag 540

Page 2991

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gtgcccactc tctttcctct gtcctgctct gatgtttcta ccaacttcct agtgctgctc 600 tgctccatcc tgcttcatgg acttgggacc ttcttcccaa tcatctcatc ctatggctgc 660 attgtctcca ccatcctgaa catcagctcg acctcaggca gaagcaaggc cttctccacc 720 tgctcctccc acctcatcgc agtgatcttc ttttatggat caggttttct ccgctatctc 780 gtgccaacct caggatcccc ccttgagttg atcttctcta tgcagtatgg tatgatcacc 840 cccatgctga atcctctcat ctatagcctg aagaacaagg aggtgaaggc agctgtgaga 900 aggacactgg gaacgtattt gccatg 926

<210> 2690 <211> 309 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (309)..(309) <223> Any amino acid <400> 2690

Met Ala Leu Gly Asn Arg Ser Thr Ile Thr Glu Phe Phe Leu Leu Gly 1 5 10 15 Leu Ser Val Asn Pro His Ile Gln Ala Leu Phe Phe Val Leu Phe Leu 20 25 30 Asn Ile Tyr Leu Leu Thr Ile Met Gly Asn Leu Leu Leu Leu Leu Val 35 40 45 Ile Arg Ala Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Leu Asp Phe Cys Leu Ser Ser Ala Thr Val Pro Arg 65 70 75 80 Met Leu Lys Asp Leu Leu Ser Glu Ile Lys Thr Ile Ser Val Arg Gly 85 90 95

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Cys Leu Ala Gln Gly Phe Phe Val Phe Ile Thr Ala Gly Thr Glu Ala 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Gly Gln Met Met Arg Lys Gln Leu Cys Val Gln Leu 130 135 140 Val Leu Gly Ser Trp Gly Leu Ser Phe Leu Asn Ala Leu Ile Asn Ile 145 150 155 160 Leu Leu Ala Ala Ser Leu Asp Phe Cys Glu Ser His Thr Ile Asn His 165 170 175 Tyr Ser Cys Glu Val Pro Thr Leu Phe Pro Leu Ser Cys Ser Asp Val 180 185 190 Ser Thr Asn Phe Leu Val Leu Leu Cys Ser Ile Leu Leu His Gly Leu 195 200 205 Gly Thr Phe Phe Pro Ile Ile Ser Ser Tyr Gly Cys Ile Val Ser Thr 210 215 220 Ile Leu Asn Ile Ser Ser Thr Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ile Ala Val Ile Phe Phe Tyr Gly Ser Gly Phe 245 250 255 Leu Arg Tyr Leu Val Pro Thr Ser Gly Ser Pro Leu Glu Leu Ile Phe 260 265 270 Ser Met Gln Tyr Gly Met Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Lys Asn Lys Glu Val Lys Ala Ala Val Arg Arg Thr Leu Gly 290 295 300

Page 2993

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Thr Tyr Leu Pro Xaa

305 <210> 2691 <211> 939 <212> DNA <213> Felis catus <400> 2691 atggacttgg ggaactacag caccatcacg gagtttatcc tcctcgggct ctccgccaat 60 ccccacgtcc aggctgcact ctttgtgctc ttcctgggga tttacctgct gaccatcatg 120 gggaacctga tgctgctgct ggtgatcagg attgattttc acctgcacac acccatgtac 180 ttcttcctga gtcacctctc ttttgtcgat atctgcttct cttcggtcac tgtgcccaag 240 atgctggaga accttctgtc tcaaaaagaa aacaatatca gtagagggct gccttgctca 300 agtcttcttt gtgtttgttg ctgcaggaac tgaagcctgt ctgctttctg caatggccta 360 tgaccgctat gctgccatct gccaccctct gctgtacgga cagatcatga gtaaacagct 420 gtatatgcag cttgtgtggg gctcttggga ctgggctttc tggatgcact catcaacatc 480 ttcctagctg tgaagatggt cttctgcaag gcccaaatca tcccccacta cagctgtgaa 540 atgccctctc tcctctcact gtcctgttcc gatatctcca gcaacctcat tgccttgctc 600 tgctccactc ttctacatgg actcggaacc ttccttttgg tcttcttatc ctacacccgt 660 ataatcgcca ccatcctgag catcagctcc accttaggca gaagtaaggc cttttccacc 720 tgctcctccc acctcatcgc agtgaccctt tactatggct caggtttgct ccgccaccta 780 atgccaaatt caggtgcgcc ccttgagctg atcttttctg tgcagtatac tgtagtcact 840 cccatgctga atcctctcat ctatagcctg aagaacaagg aggtgaaggc agctctggca 900 agaactttgg aaaagtattt gcaacatatc aggtgctga 939 <210> 2692 <211> 110 <212> PRT <213> Felis catus <400> 2692

Met Asp Leu Gly Asn Tyr Ser Thr Ile Thr Glu Phe Ile Leu Leu Gly 1 5 10 15

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Leu Ser Ala Asn 20 Pro His Val Gln Ala Ala Leu Phe Val Leu Phe Leu 25 30 Gly Ile Tyr Leu Leu Thr Ile Met Gly Asn Leu Met Leu Leu Leu Val 35 40 45 Ile Arg Ile Asp Phe His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Ile Cys Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Asn Leu Leu Ser Gln Lys Glu Asn Asn Ile Ser Arg Gly 85 90 95 Leu Pro Cys Ser Ser Leu Leu Cys Val Cys Cys Cys Arg Asn 100 105 110

<210> 2693 <211> 957 <212> DNA <213> Felis catus <400> 2693

atggccttgg taaatcacag caccatcatt gagtttctcc ttcttggagt ccctgaagat 60 catcataccc gggctctagt ctttgtgctt ttcctggtag tttacctcct gactctgtca 120 gggaacctgt tgataatcct ggttatcagg accaattctc accttcacac acccatgtac 180 ttcttcttga atcacctctc cttcctggat ctctgttact cttcggtcac tgtgcccaag 240 atgctagaga acctcctgtc tgagaagaaa gccatctcag tggaagactg tttgacccag 300 gccttctttg tgcttgcctt tgggggaaca gagctctgcc tccttgcagt catggcctat 360 gaccgctatg ctgccatttg ctaccctcta ctctatggtc agatgatgag caatgagctg 420 tgtgtgggac tggcgtgggg atcttggggt ctggcctttt tggatgcttt catcaatacc 480 ctcctagcct ggaatttgga cttctgtgag acgcaagtca tctccaactt catttgtgag 540 attccttctc tgttccctct atcctgttcc aatagctctg acaactttgc agttctgctc 600 ggctctgccc tcctgcatgc ctttgggacc ttcattctgg tcttcttctc ttacgcccgt 660

Page 2995

069269_0225_SL.TXT attgtctcca ccatcctgag catcacctcc acctcaggca gaagcaaggc cttctccacc tgctcctccc acctcaccgc agtgagctta ttttacggct caggttttct tcgctatctc atgccaacct caggttcccc gtgggagttg gttttttcca tgcagtacag tgtggtcact cccctagcga atccccttgt ttatagccta aagaacaagg aagtaaaagc atctctgaaa aacatgttgc agaaaagttt acaacatctc aggtagcaga tggcaagcag cggatga

720

780

840

900

957 <210> 2694 <211> 311 <212> PRT <213> Felis catus <400> 2694

Met Ala Leu Val Asn His Ser Thr Ile Ile Glu Phe Leu Leu Leu Gly 1 5 10 15

Val Pro Glu Asp His His Thr Arg Ala Leu Val Phe Val Leu Phe Leu 20 25 30

Val Val Tyr Leu Leu Thr Leu Ser Gly Asn Leu Leu Ile Ile Leu Val 35 40 45

Ile Arg Thr Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Asn 50 55 60

His Leu Ser Phe Leu Asp Leu Cys Tyr Ser Ser Val Thr Val Pro Lys 65 70 75 80

Met Leu Glu Asn Leu Leu Ser Glu Lys Lys Ala Ile Ser Val Glu Asp 85 90 95

Cys Leu Thr Gln Ala Phe Phe Val Leu Ala Phe Gly Gly Thr Glu Leu 100 105 110

Cys Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Tyr 115 120 125

Pro Leu Leu Tyr Gly Gln Met Met Ser Asn Glu Leu Cys Val Gly Leu 130 135 140

Page 2996

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Ala 145 Trp Gly Ser Trp Gly 150 Leu Ala Phe Leu Asp Ala Phe Ile Asn Thr 155 160 Leu Leu Ala Trp Asn Leu Asp Phe Cys Glu Thr Gln Val Ile Ser Asn 165 170 175 Phe Ile Cys Glu Ile Pro Ser Leu Phe Pro Leu Ser Cys Ser Asn Ser 180 185 190 Ser Asp Asn Phe Ala Val Leu Leu Gly Ser Ala Leu Leu His Ala Phe 195 200 205 Gly Thr Phe Ile Leu Val Phe Phe Ser Tyr Ala Arg Ile Val Ser Thr 210 215 220 Ile Leu Ser Ile Thr Ser Thr Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ser Leu Phe Tyr Gly Ser Gly Phe 245 250 255 Leu Arg Tyr Leu Met Pro Thr Ser Gly Ser Pro Trp Glu Leu Val Phe 260 265 270 Ser Met Gln Tyr Ser Val Val Thr Pro Leu Ala Asn Pro Leu Val Tyr 275 280 285 Ser Leu Lys Asn Lys Glu Val Lys Ala Ser Leu Lys Asn Met Leu Gln 290 295 300 Lys Ser Leu Gln His Leu Arg

305 310 <210> 2695 <211> 936 <212> DNA <213> Felis catus <400> 2695

Page 2997

069269_0225_SL.TXT atggctttga ggaaccacag caccatcaca gagttcatcc tccttggcct gtctgttgac 60 tcccacgtcc aggttctgct ctttgtgctt ttccttggga tttacctctt tactataatg 120 ggaaatctat cgatgctgtt ggtcatcagg gaagatcccc atctccacac acctatgtac 180 ttcttcctga gccacctctc tttcatggac ttttgtctct ctactgccat agtgcccaag 240 ctgctggaga acctcctgtc tcagagcaaa accatctcag ttgggggctg cctggctcaa 300 gccttctttg tgtttgacat tggaggaaca gaagtctgct tactttcagc aatggcctat 360 gaccgttatg ctgctatctg tcacccactc ctctatggcc gggtaatgaa taatcagctg 420 tatatgcagc ttgtatgggg ctcatggagc ctggggtttc tagatgcact cattaacacc 480 cccctgacaa tgaacttgga tttctgtgaa gcgaaaatca tccatcacta tagctgtgag 540 ttgccctccc tcttcccttt gtcctgctct gatgtctcta ccagcctcac tgtcctggtc 600 tgttctacac tcctgcatgg cggtggtaca ttcttcctga ttttcttctc ctatgtgcgc 660 attgtctcca ccatcctgag cattagctcc tcctcaggca gaagcaaggc cttctccacc 720 tgctcctctc acctcactgc attgagcttc ttctatggct cagctttcct ccgttatctc 780 atgccaacct caggctcacc tctggagctc atcttctcca tacagtatgg tgtggtcact 840 cccctagtga atcccctcat ctacagcctg aaaaacaagg aggttaaaaa tgcactgaga 900 agaaccttgg gaaagtgttt gcaatagtac atgtag 936 <210> 2696 <211> 308 <212> PRT <213> Felis catus

<400> 2696 Met 1 Ala Leu Arg Asn His Ser Thr Ile Thr Glu Phe Ile Leu Leu Gly 5 10 15 Leu Ser Val Asp Ser His Val Gln Val Leu Leu Phe Val Leu Phe Leu 20 25 30 Gly Ile Tyr Leu Phe Thr Ile Met Gly Asn Leu Ser Met Leu Leu Val 35 40 45 Ile Arg Glu Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Page 2998

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50 55 60 His Leu Ser Phe Met Asp Phe Cys Leu Ser Thr Ala Ile Val Pro Lys 65 70 75 80 Leu Leu Glu Asn Leu Leu Ser Gln Ser Lys Thr Ile Ser Val Gly Gly 85 90 95 Cys Leu Ala Gln Ala Phe Phe Val Phe Asp Ile Gly Gly Thr Glu Val 100 105 110 Cys Leu Leu Ser Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Gly Arg Val Met Asn Asn Gln Leu Tyr Met Gln Leu 130 135 140 Val Trp Gly Ser Trp Ser Leu Gly Phe Leu Asp Ala Leu Ile Asn Thr 145 150 155 160 Pro Leu Thr Met Asn Leu Asp Phe Cys Glu Ala Lys Ile Ile His His 165 170 175 Tyr Ser Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Ser Asp Val 180 185 190 Ser Thr Ser Leu Thr Val Leu Val Cys Ser Thr Leu Leu His Gly Gly 195 200 205 Gly Thr Phe Phe Leu Ile Phe Phe Ser Tyr Val Arg Ile Val Ser Thr 210 215 220 Ile Leu Ser Ile Ser Ser Ser Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Leu Ser Phe Phe Tyr Gly Ser Ala Phe 245 250 255 Leu Arg Tyr Leu Met Pro Thr Ser Gly Ser Pro Leu Glu Leu Ile Phe

Page 2999

260

069269_0225_SL.TXT 265 270

Ser Ile Gln Tyr Gly Val Val Thr Pro Leu Val Asn Pro Leu Ile Tyr 275 280 285

Ser Leu Lys Asn Lys Glu Val Lys Asn Ala Leu Arg Arg Thr Leu Gly 290 295 300

Lys Cys Leu Gln

305 <210> 2697 <211> 947 <212> DNA <213> Felis catus <400> 2697

atggtcttgg gaaaccacag caccatcaca gaattcatcc tccttgggct atctgctgac 60 cctcacaccc aaattctcct ctttgcattt ttcctggaaa tttacctcct gaccatcatg 120 gggaacctga tgatgatgat ggcgattatg actgattccc atctccacac ccccatgtac 180 ttcttcttga gtcacctctc cttcctggat ctttgtttaa cttcagtcac tgtgcccaag 240 atgctggaga atctcctgtc tcagaagaaa tcagtatcca tagaaagctg cctcgctcag 300 gcattttttg tgttttccat cgcagggact gaagcttttg tgctctctgc catggcctat 360 gaccgctata ctgccatctg caaccccctg ctctatgacc aggtgatgag taaacagctg 420 tgtgggggtc tggtatgggt ctcatgggga ctgggctttc tggatgctct cattaacacc 480 ctcacggctt gcaatttgga cttctgtgag gctcgtgtca tacctcactt cagctgtgaa 540 ctgccatctc tattctctct gtcttgctct gatatctcca ccaactttgc agtcctggtg 600 tgctctgcca tcattcatgc ctctggaacc ttactcctgg tcttcttctc ttacacccgt 660 attatctcca ccatcctgag catcacctcc acctcaggca gaagcaaggc cttctccacc 720 tgctcctccc acctcactgc agtgagtttc ttctatggat ctgcttttct tcgctatctc 780 atgccaacct taagttcccc gctggagtta attttttcca tacagtacag tgtggtcact 840 cctctagtga atccccttgt ctacagcttg aagaacaagg aagtaaaagc agctgtgcaa 900 agaatgttgc aaaaaggttt acaacagctc agagagcaga gaacagg 947

Page 3000

069269_0225_SL.TXT <210> 2698 <211> 316 <212> PRT <213> Felis catus

<400> 2698 Met 1 Val Leu Gly Asn 5 His Ser Thr Ile Thr Glu Phe Ile Leu Leu Gly 10 15 Leu Ser Ala Asp Pro His Thr Gln Ile Leu Leu Phe Ala Phe Phe Leu 20 25 30 Glu Ile Tyr Leu Leu Thr Ile Met Gly Asn Leu Met Met Met Met Ala 35 40 45 Ile Met Thr Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Leu Asp Leu Cys Leu Thr Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Glu Asn Leu Leu Ser Gln Lys Lys Ser Val Ser Ile Glu Ser 85 90 95 Cys Leu Ala Gln Ala Phe Phe Val Phe Ser Ile Ala Gly Thr Glu Ala 100 105 110 Phe Val Leu Ser Ala Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asp Gln Val Met Ser Lys Gln Leu Cys Gly Gly Leu 130 135 140 Val Trp Val Ser Trp Gly Leu Gly Phe Leu Asp Ala Leu Ile Asn Thr 145 150 155 160 Leu Thr Ala Cys Asn Leu Asp Phe Cys Glu Ala Arg Val Ile Pro His 165 170 175

Page 3001

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Phe Ser Cys Glu Leu Pro Ser Leu Phe Ser Leu Ser Cys Ser Asp Ile 180 185 190 Ser Thr Asn Phe Ala Val Leu Val Cys Ser Ala Ile Ile His Ala Ser 195 200 205 Gly Thr Leu Leu Leu Val Phe Phe Ser Tyr Thr Arg Ile Ile Ser Thr 210 215 220 Ile Leu Ser Ile Thr Ser Thr Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ser Phe Phe Tyr Gly Ser Ala Phe 245 250 255 Leu Arg Tyr Leu Met Pro Thr Leu Ser Ser Pro Leu Glu Leu Ile Phe 260 265 270 Ser Ile Gln Tyr Ser Val Val Thr Pro Leu Val Asn Pro Leu Val Tyr 275 280 285 Ser Leu Lys Asn Lys Glu Val Lys Ala Ala Val Gln Arg Met Leu Gln 290 295 300 Lys Gly Leu Gln Gln Leu Arg Glu Gln Arg Thr Gly

305 310 315 <210> 2699 <211> 948 <212> DNA <213> Felis catus <400> 2699 atggcctcag ggaatcacag ccgcatcaca gagttcattc tcctcgggct gtctgctgac ccccatgtcc aggctctgct ctttgttctg ttcctgatga tttaccttct gactctgctg gggaacctgc tgatcatact cgtgatccat acagactcta acctccgcac acccatgtac ttcttcctca gccacctctc cttccaagac ctcttctatt cttccgtcac tgtgcccaag ctgctggaga acctcctgtc tcagagaaaa gccatctcag tagagggctg cctggctcag

120

180

240

300

Page 3002

069269_0225_SL.TXT

gtattctttg tgtttgccac tacggggatt gaggcttgcc tgctctcagt gatggcctat 360 gaccgctatg ccgccatctg ccaccctctg ctctatggcc aggtgatgag taaacagcta 420 tgtgagaggc tggtgtgggg ttcttgggtt gtggcctttc tggatgcact catgaacatc 480 ctcctggctt tgaatatgga cttctgtgat gttcaaacca tccaccacta ctcctgtgag 540 ctgccttccc tcttccctct ctcctgctct gatgtctcca ccaactctgc gatgctactc 600 tgctctgcgc tcctgcatgc cattgggacc tgcctcctga tctttttctc ttacgttcgc 660 attgtctcca ccatcctgag catcggctcc acctcaggca gaagcaaggc cttctccacc 720 tgctcctccc acctgactgc agtgagcctg ttctatggct cagccatttt tcgctatctc 780 atgccaacct cgggttcacc tctggagctg atcctctcca tacagtacag tgtaatcacg 840 cccctggtga atccgctcat ctacagctgg aagaacaagg aggtgaaggc agctctgagg 900 agaatgacga taaaatattt acaatgtctc agcacagaag agatataa 948

<210> 2700 <211> 315 <212> PRT <213> Felis catus <400> 2700

Met Ala Ser Gly Asn His Ser Arg Ile Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Ala Asp Pro His Val Gln Ala Leu Leu Phe Val Leu Phe Leu 20 25 30 Met Ile Tyr Leu Leu Thr Leu Leu Gly Asn Leu Leu Ile Ile Leu Val 35 40 45 Ile His Thr Asp Ser Asn Leu Arg Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Gln Asp Leu Phe Tyr Ser Ser Val Thr Val Pro Lys 65 70 75 80 Leu Leu Glu Asn Leu Leu Ser Gln Arg Lys Ala Ile Ser Val Glu Gly 85 90 95

Page 3003

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Cys Leu Ala Gln Val Phe Phe Val Phe Ala Thr Thr Gly Ile Glu Ala 100 105 110 Cys Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Gly Gln Val Met Ser Lys Gln Leu Cys Glu Arg Leu 130 135 140 Val Trp Gly Ser Trp Val Val Ala Phe Leu Asp Ala Leu Met Asn Ile 145 150 155 160 Leu Leu Ala Leu Asn Met Asp Phe Cys Asp Val Gln Thr Ile His His 165 170 175 Tyr Ser Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Ser Asp Val 180 185 190 Ser Thr Asn Ser Ala Met Leu Leu Cys Ser Ala Leu Leu His Ala Ile 195 200 205 Gly Thr Cys Leu Leu Ile Phe Phe Ser Tyr Val Arg Ile Val Ser Thr 210 215 220 Ile Leu Ser Ile Gly Ser Thr Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ser Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Phe Arg Tyr Leu Met Pro Thr Ser Gly Ser Pro Leu Glu Leu Ile Leu 260 265 270 Ser Ile Gln Tyr Ser Val Ile Thr Pro Leu Val Asn Pro Leu Ile Tyr 275 280 285 Ser Trp Lys Asn Lys Glu Val Lys Ala Ala Leu Arg Arg Met Thr Ile 290 295 300

Page 3004

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Lys Tyr Leu Gln Cys Leu Ser Thr Glu Glu Ile 305 310 315 <210> 2701 <211> 929 <212> DNA <213> Felis catus <400> 2701

atggccttga gaaaccacag caccatcacg gagttcatcc tccttgggct gtcggctgac 60 cccgaagtcc aggcgctgct ctttgcgctc ttcctgggga tttacctcct gaccatgatg 120 gggaacctga tgatgctgct ggtgaccaga gctgattccc agctccacac acccatgtat 180 tatttcctga gtcatctctc cttcctggat ctttgctttt cttcagtcac tgtgcccaag 240 cttctggaga acctcctgtc tgaaaggaaa atcatctcaa aagagggctg cctgattcaa 300 gctttctttg tgttggccat tggaggaaca gaaattttcc tgctgtctgc catggcctat 360 gaccgctatg ctgccatctg ccaccctctg ctctatggcc agatgatgag cagccagctg 420 tgtgtaaggc tggtatgggt ttcatggagc ctgggtttcc tggatgcagt tatcaacatc 480 cccctggcta tgaacttgaa cttctgtgaa gcccatacca tctcccacta cagctgtgag 540 ctaccctctc tctttccttt gtcctgctct gacgtctcca gcaatgtcac tgtcctgatt 600 gcttccacac tcttgcatgg ctttggtaca ttcgtcctga tcttcttctc ttatgcccgt 660 gttgcaacca ccatcctgag catcagctcc accacaggca gaagcaaggc cttctccacc 720 tgctcctccc acctcaccac agtgagcttc ttctatggat cagctttcct tcgttatctc 780 gtgccaactt caggctcacc gctggagctc atcttctcca tacagtatgg tgtggtcact 840 cccctaatga atcccctcat ctatagcctg aaaaacaaag aagtaaaggc ggctctgaga 900 agaatgttgg agaaatgttt gcagtggca 929

<210> 2702 <211> 310 <212> PRT <213> Felis catus <220>

<221> MOD_RES

Page 3005

069269_0225_SL.TXT <222> (310)..(310) <223> Any amino acid

<400> 2702 Ile Leu Leu 15 Gly Met 1 Ala Leu Arg Asn His Ser Thr 5 Ile Thr 10 Glu Phe Leu Ser Ala Asp Pro Glu Val Gln Ala Leu Leu Phe Ala Leu Phe Leu 20 25 30 Gly Ile Tyr Leu Leu Thr Met Met Gly Asn Leu Met Met Leu Leu Val 35 40 45 Thr Arg Ala Asp Ser Gln Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 His Leu Ser Phe Leu Asp Leu Cys Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Leu Leu Glu Asn Leu Leu Ser Glu Arg Lys Ile Ile Ser Lys Glu Gly 85 90 95 Cys Leu Ile Gln Ala Phe Phe Val Leu Ala Ile Gly Gly Thr Glu Ile 100 105 110 Phe Leu Leu Ser Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Gly Gln Met Met Ser Ser Gln Leu Cys Val Arg Leu 130 135 140 Val Trp Val Ser Trp Ser Leu Gly Phe Leu Asp Ala Val Ile Asn Ile 145 150 155 160 Pro Leu Ala Met Asn Leu Asn Phe Cys Glu Ala His Thr Ile Ser His 165 170 175 Tyr Ser Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Ser Asp Val 180 185 190

Page 3006

Ser Ser Asn 195 Val Thr Val Leu 069269_0225_SL.TXT Ile Ala Ser Thr Leu Leu 200 205 His Gly Phe Gly Thr Phe Val Leu Ile Phe Phe Ser Tyr Ala Arg Val Ala Thr Thr 210 215 220 Ile Leu Ser Ile Ser Ser Thr Thr Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Thr Val Ser Phe Phe Tyr Gly Ser Ala Phe 245 250 255 Leu Arg Tyr Leu Val Pro Thr Ser Gly Ser Pro Leu Glu Leu Ile Phe 260 265 270 Ser Ile Gln Tyr Gly Val Val Thr Pro Leu Met Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Lys Asn Lys Glu Val Lys Ala Ala Leu Arg Arg Met Leu Glu 290 295 300 Lys Cys Leu Gln Trp Xaa

305 310 <210> 2703 <211> 943 <212> DNA <213> Felis catus <400> 2703

atggcctgga ggaaccacag catcatcacc gagttcattc tcacggggct gtccgacgac 60 ccccacatcc aggctctgct cttcgtgctc ttcctgggga tttacctcct gaccgtgatg 120 gggaatctga tgctgctgct ggtgatcagg accgactccc gcctccacac gcccatgtac 180 ttcttcctga gtaacctgtc cttcatggac ctttgcttct cttctgtcac tatgcccaag 240 ctactgaagg accttctgtc tgagaagaaa accatctcag tagaaggctg cctgactcag 300 gtgttctttg tgtttttttc ttcggggact gaagcctgtc tgctctcggt gatggcctat 360 gaccgctatg ccgccatctg ccaccctctg ctctacggcc aagtgatgag cagccagctt 420

Page 3007

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tgtgtggggc tggtgctggc ctcatggggc ctggcctctc tcaatgcatt tgtcattgtg 480 cttttggcta ttaacctgga cttctgtgag gcccaaacca tccaccacta cacctgtgag 540 ctgcctgctc ttttccctct gtcttgttct gatatctcca tcacaaccaa tatcctgctc 600 tgctccagtt tactgcacgg gctgggaacc ttcctcccaa tctttttctc ttatgcccgt 660 attatctcca ccatcctgca catcagctcc acctcaggca gaagcaaggc cttctccacc 720 tgctcctccc acctcatcgc agtgatcctg ttctttggct caggttttct ttgttatctc 780 atgcccccct cgggttcctc tttggatttg ctcctctcct tacagtacag tgcagtcacg 840 cccttgctga atcccctcat ctacagccta aagaacgtag aggtgaaggc ggctgtgaga 900 aggacactgg ggaaatatct ctaatgtagt gaacaaagac aca 943

<210> 2704 <211> 307 <212> PRT <213> Felis catus <400> 2704

Met Ala Trp Arg Asn His Ser Ile Ile Thr Glu Phe Ile Leu Thr Gly 1 5 10 15 Leu Ser Asp Asp Pro His Ile Gln Ala Leu Leu Phe Val Leu Phe Leu 20 25 30 Gly Ile Tyr Leu Leu Thr Val Met Gly Asn Leu Met Leu Leu Leu Val 35 40 45 Ile Arg Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Met Asp Leu Cys Phe Ser Ser Val Thr Met Pro Lys 65 70 75 80 Leu Leu Lys Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Val Glu Gly 85 90 95 Cys Leu Thr Gln Val Phe Phe Val Phe Phe Ser Ser Gly Thr Glu Ala 100 105 110

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Cys Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Gly Gln Val Met Ser Ser Gln Leu Cys Val Gly Leu 130 135 140 Val Leu Ala Ser Trp Gly Leu Ala Ser Leu Asn Ala Phe Val Ile Val 145 150 155 160 Leu Leu Ala Ile Asn Leu Asp Phe Cys Glu Ala Gln Thr Ile His His 165 170 175 Tyr Thr Cys Glu Leu Pro Ala Leu Phe Pro Leu Ser Cys Ser Asp Ile 180 185 190 Ser Ile Thr Thr Asn Ile Leu Leu Cys Ser Ser Leu Leu His Gly Leu 195 200 205 Gly Thr Phe Leu Pro Ile Phe Phe Ser Tyr Ala Arg Ile Ile Ser Thr 210 215 220 Ile Leu His Ile Ser Ser Thr Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ile Ala Val Ile Leu Phe Phe Gly Ser Gly Phe 245 250 255 Leu Cys Tyr Leu Met Pro Pro Ser Gly Ser Ser Leu Asp Leu Leu Leu 260 265 270 Ser Leu Gln Tyr Ser Ala Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Lys Asn Val Glu Val Lys Ala Ala Val Arg Arg Thr Leu Gly 290 295 300

Lys Tyr Leu 305

Page 3009

069269_0225_SL.TXT <210> 2705 <211> 925 <212> DNA <213> Felis catus <400> 2705

atggcctgga ggaaccacag catcatcacc gagttcattc tcacggggct gtccgacgac 60 ccccacatcc aggctctgct cttcgtgctc ttcctgggga tttacctcct gaccgtgatg 120 gggaatctga tgctgctgct ggtgatcagg accgactccc gcctccacac gcccatgtac 180 ttcttcctga gtaacctgtc cttcctggac ctctgcttct cttccgtcac tgtgcccaag 240 ctactgaagg accttctgtc tgagaagaaa accatctcag tggagggctg cctggctcag 300 gtgttcttcg tgtttatcac cgcagggact gaagcctttc tgctctcggt gatggcctat 360 gaccgctatg ccgccatctg ccaccctctg ctctacggcc acgtgatgag cagccagctc 420 tgtgtgaggc tggtgctggc ctcatggggc ctggcttccc tcaattcagt catcattgtg 480 cttttggcta ttaacctgga cttctgtgag gcccaaacca tccaccacta cacctgtgag 540 ctgccctccc tcttccctct gtcttgctct gatatttcca tcaatattga catcttgatc 600 tgctccacct tactgcacgg gctgggaacc ttcctcccaa tctttttctc ctatgcccgt 660 attgtctcca ccatcctgca catcagctcc acctcaggca gaagcaaggc cttctccacc 720 tgctcctccc acctcatcgc agtgatcctg ttctttggct caggtttgat tcgctatctt 780 atgcccacct cgggttcctc cctggatttg ctctcctcct tacagtacag tgcagtcacg 840 cccttgctga atcccctcat ctacagccta aagaatgtag aggtgaaggc ggctgtgaga 900 aggacagtgg agaaatacct acact 925

<210> 2706 <211> 309 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (309)..(309) <223> Any amino acid <400> 2706

Page 3010

Met 1 Ala Trp Arg Asn 5 His Ser 069269_0225_SL.TXT Ile Ile Thr Glu Phe Ile 10 Leu Thr 15 Gly Leu Ser Asp Asp Pro His Ile Gln Ala Leu Leu Phe Val Leu Phe Leu 20 25 30 Gly Ile Tyr Leu Leu Thr Val Met Gly Asn Leu Met Leu Leu Leu Val 35 40 45 Ile Arg Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Leu Leu Lys Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Val Glu Gly 85 90 95 Cys Leu Ala Gln Val Phe Phe Val Phe Ile Thr Ala Gly Thr Glu Ala 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu Leu Tyr Gly His Val Met Ser Ser Gln Leu Cys Val Arg Leu 130 135 140 Val Leu Ala Ser Trp Gly Leu Ala Ser Leu Asn Ser Val Ile Ile Val 145 150 155 160 Leu Leu Ala Ile Asn Leu Asp Phe Cys Glu Ala Gln Thr Ile His His 165 170 175 Tyr Thr Cys Glu Leu Pro Ser Leu Phe Pro Leu Ser Cys Ser Asp Ile 180 185 190 Ser Ile Asn Ile Asp Ile Leu Ile Cys Ser Thr Leu Leu His Gly Leu 195 200 205

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Gly Thr Phe Leu Pro Ile Phe Phe Ser Tyr Ala Arg Ile Val Ser Thr 210 215 220 Ile Leu His Ile Ser Ser Thr Ser Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ile Ala Val Ile Leu Phe Phe Gly Ser Gly Leu 245 250 255 Ile Arg Tyr Leu Met Pro Thr Ser Gly Ser Ser Leu Asp Leu Leu Ser 260 265 270 Ser Leu Gln Tyr Ser Ala Val Thr Pro Leu Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Lys Asn Val Glu Val Lys Ala Ala Val Arg Arg Thr Val Glu 290 295 300 Lys Tyr Leu His Xaa

305

<210> 2707 <211> 891 <212> DNA <213> Felis catus <400> 2707 gaaaaccaga ccacctggct gatcctggtt ggctttgggg agctgcaaca cctgggcttc 60 ctccccttca ccttcttttt agccatctat gtggtaacag ttgggggcaa cgccctcatc 120 gtgctggctg tggcctccag tcggacactc cacacaccca tgtacttctt cctctgccac 180 ttttccttgc tggagattgg ctacacctcc aacatcatgc ctcagctgct gcagagcttc 240 ctgaaaggga gggaggccat ctcactggtc agctgtctgg tccagttcta catgtttgcc 300 tcgctggctg cagttgagtg cctcctgcta tctgctatgt cctatgaccg ttacctggcc 360 atctgccacc cacttcgcta ccctgtcctg atgagcacat ggttgtgtgg ctgcctggct 420 gctggagtct gggtcagtgg attttctttc tctgccttca ctctggccct ggcagcccct 480 ctgaccctct gccctggcaa cagggagatc gaccactact tctgtgactt tgctccagtt 540

Page 3012

069269_0225_SL.TXT gtagggctgt tctgtggaga tgtgggggtt atgtgggcag ctggagtgag catctcaggc 600 tttctgacac tggtcccctt cctgttgatt gtggcatcct atgccttcat cttaaggact 660 gtgctgcaaa taccttcagg ccatggtaga cagaaagctt tctccacctg ttcctcccac 720 ctcagtgtgg tcggggtgta ttatggcact ctcattgtgg tctatgtagc cccaacagac 780 cacatggccc ccttgctccg aaaggccttc tctgtcctct acactgtatt cacccctatg 840 gtcaacccca ttatttacag cctcaagaac caagaggtaa agggggccct t 891 <210> 2708 <211> 297 <212> PRT <213> Felis catus

<400> 2708 Trp Leu Ile Leu Val Gly Phe Gly Glu Leu Gln Glu 1 Asn Gln Thr Thr 5 10 15 His Leu Gly Phe Leu Pro Phe Thr Phe Phe Leu Ala Ile Tyr Val Val 20 25 30 Thr Val Gly Gly Asn Ala Leu Ile Val Leu Ala Val Ala Ser Ser Arg 35 40 45 Thr Leu His Thr Pro Met Tyr Phe Phe Leu Cys His Phe Ser Leu Leu 50 55 60 Glu Ile Gly Tyr Thr Ser Asn Ile Met Pro Gln Leu Leu Gln Ser Phe 65 70 75 80 Leu Lys Gly Arg Glu Ala Ile Ser Leu Val Ser Cys Leu Val Gln Phe 85 90 95 Tyr Met Phe Ala Ser Leu Ala Ala Val Glu Cys Leu Leu Leu Ser Ala 100 105 110 Met Ser Tyr Asp Arg Tyr Leu Ala Ile Cys His Pro Leu Arg Tyr Pro 115 120 125

Val

Leu Met Ser Thr Trp

Leu Cys

Gly Cys

Leu Ala

Ala Gly Val Trp

Page 3013

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130 135 140

Val Ser Gly Phe 145 Ser Phe Ser Ala Phe Thr Leu Ala Leu Ala Ala Pro 160 150 155 Leu Thr Leu Cys Pro Gly Asn Arg Glu Ile Asp His Tyr Phe Cys Asp 165 170 175 Phe Ala Pro Val Val Gly Leu Phe Cys Gly Asp Val Gly Val Met Trp 180 185 190 Ala Ala Gly Val Ser Ile Ser Gly Phe Leu Thr Leu Val Pro Phe Leu 195 200 205 Leu Ile Val Ala Ser Tyr Ala Phe Ile Leu Arg Thr Val Leu Gln Ile 210 215 220 Pro Ser Gly His Gly Arg Gln Lys Ala Phe Ser Thr Cys Ser Ser His 225 230 235 240 Leu Ser Val Val Gly Val Tyr Tyr Gly Thr Leu Ile Val Val Tyr Val 245 250 255 Ala Pro Thr Asp His Met Ala Pro Leu Leu Arg Lys Ala Phe Ser Val 260 265 270 Leu Tyr Thr Val Phe Thr Pro Met Val Asn Pro Ile Ile Tyr Ser Leu 275 280 285 Lys Asn Gln Glu Val Lys Gly Ala Leu

290 295 <210> 2709 <211> 874 <212> DNA <213> Felis catus <400> 2709 atgggtgata agggagcagg caaccactca gatgtaactg acttcattct tgtaggcttc agggtctgtc cagaactcca cattctcttc ttcctcctat tcctgctggt ctatggcatg

120

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gtccttttgg gtaacattag tatgatggca atcattgtga cagactccca gctgaataca 180 ccaatgtttc tttcgaggca atctctcctt cattgacctc tcctactcca ctgttattgc 240 ccaaaaagcc atggtcaact tcctgtctga gaaaaagact atctcttttg caggttttgt 300 ggctcagctg ttcctttatg catttttcat ggttacagaa gcttttctcc tggcagtcat 360 ggaatatgac cgcttcattg ccataggcaa ccctcttctt tacagtgtgc acatgtcaag 420 acgactttgc actcagctgg tggctggttc ctatctctgt ggatggctca gttccatcct 480 ccaagtcagc acaacattct cagtgtcttt ctgtgcttcc cgagtcattg atcacttcta 540 ctgtgattct taccaaattg agaagatctc ctgctccaat ctctctgtca ataagatggt 600 gtctcttagt ttggctgcct tcattatttt gcccaccata gttgttattg tagtatctta 660 catgtacatt tgaccacagt cttgaaaatc ccttccagtg gagggagaaa gaaagccttc 720 tccacctgca gctcccattt gggagtggta agtttgctct atgggactgt ctcctttgtg 780 tatctcacac ctccaagcaa tcctgaactt gcttaaagtg gcttcagtat tttacatatt 840 ggtcacactc atgttaaatc ctctgatcta ctct 874

<210> 2710 <211> 71 <212> PRT <213> Felis catus <400> 2710

Met 1 Gly Asp Lys Gly Ala Gly Asn His Ser Asp Val Thr Asp Phe Ile 5 10 15 Leu Val Gly Phe Arg Val Cys Pro Glu Leu His Ile Leu Phe Phe Leu 20 25 30 Leu Phe Leu Leu Val Tyr Gly Met Val Leu Leu Gly Asn Ile Ser Met 35 40 45 Met Ala Ile Ile Val Thr Asp Ser Gln Leu Asn Thr Pro Met Phe Leu 50 55 60 Ser Arg Gln Ser Leu Leu His

65 70

Page 3015

069269_0225_SL.TXT <210> 2711 <211> 946 <212> DNA <213> Felis catus <400> 2711

atgggtgaca agggaggaga caaccactca gaagtgactg acttcattct tgtaggcatc 60 agggtccgtc cagagctcca cagtctcctc ttcctactat tcctggttgt ttatgggatg 120 gtccttctgg ggaaccttag tatgattggc atcattgtga ccgatccccg gctgaacaca 180 ccaatgtatt tcttcctagg caatctctcc atcattgacc tctcctactc cactgttatt 240 gtacccaaag ccatggtcaa catcctatct cagaaaaaga ccatatcctt tgcaggctgt 300 gtgactcagc tatttcttta tgcacttttc atggtcaccg aggcctttgt cctggcagcc 360 atggcctatg accgcttcat cgccatctgc aatccactcc tctacactgt ccgcatgtca 420 agaagcctct gtatccagtt ggtggctggt tcctatctct gtggctgggt cagttccatc 480 cttcaaatca gtgtaacatt ctcaatgtct ttctgtgctt cccgagtcat tgatcacttc 540 tactgtgatt caaaccccat cgagaagatc tcctgttcca atatctttat gaataagatg 600 gtgtcattca gtctggctgt cctcattatt ttgcccacaa tagttgttat tgtggtatct 660 tacatgtata ttgtgtctgc agttttaaaa atccgctcca gtgaagggag gaagaaagcc 720 ttctccactt gcagctcaca cctgggagtt gtcagtttgc tctatggaac tgtttccttt 780 gtctatctca cacctccaaa taaccctgaa cttcgtaaag tggcttcagt atgttacatt 840 ttgttcacac ctatgctgaa ccctttaatc tactctctga gaaataaaga tgttaaagat 900 gccgtgaaaa aagtcatatg gaagcaaaaa gttttacttt aaatct 946

<210> 2712 <211> 313 <212> PRT <213> Felis catus <400> 2712

Met Gly Asp Lys Gly Gly Asp Asn His Ser Glu Val Thr Asp Phe Ile

1 5 10 15

Leu Val Gly Ile Arg Val Arg Pro Glu Leu His Ser Leu Leu Phe Leu

Page 3016

069269_0225_SL.TXT 25 30

Leu Phe Leu 35 Val Val Tyr Gly Met Val Leu Leu Gly Asn Leu Ser Met 40 45 Ile Gly Ile Ile Val Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Ile Ile Asp Leu Ser Tyr Ser Thr Val Ile 65 70 75 80 Val Pro Lys Ala Met Val Asn Ile Leu Ser Gln Lys Lys Thr Ile Ser 85 90 95 Phe Ala Gly Cys Val Thr Gln Leu Phe Leu Tyr Ala Leu Phe Met Val 100 105 110 Thr Glu Ala Phe Val Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Thr Val Arg Met Ser Arg Ser Leu Cys 130 135 140 Ile Gln Leu Val Ala Gly Ser Tyr Leu Cys Gly Trp Val Ser Ser Ile 145 150 155 160 Leu Gln Ile Ser Val Thr Phe Ser Met Ser Phe Cys Ala Ser Arg Val 165 170 175 Ile Asp His Phe Tyr Cys Asp Ser Asn Pro Ile Glu Lys Ile Ser Cys 180 185 190 Ser Asn Ile Phe Met Asn Lys Met Val Ser Phe Ser Leu Ala Val Leu 195 200 205 Ile Ile Leu Pro Thr Ile Val Val Ile Val Val Ser Tyr Met Tyr Ile 210 215 220 Val Ser Ala Val Leu Lys Ile Arg Ser Ser Glu Gly Arg Lys Lys Ala

Page 3017

0 6926 9_02 25_S L.TX T 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Leu Leu Tyr Gly 245 250 255 Thr Val Ser Phe Val Tyr Leu Thr Pro Pro Asn Asn Pro Glu Leu Arg 260 265 270 Lys Val Ala Ser Val Cys Tyr Ile Leu Phe Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Val Lys Lys 290 295 300 Val Ile Trp Lys Gln Lys Val Leu Leu 305 310

<210> 2713 <211> 942 <212> DNA <213> Felis catus <400> 2713 atgggtgaca ggggaccaga caatcactcg gaagtgactg acttcatcct tgtaggcttc agggtccgcc ctgagctcca cattctcctc ttcctgatct ttctgcttgt gtatgccatg atcctcctag ggaatgttgg gatgatgacc attattatgg ccgatccccg gctgaacaca cccatgtatt tcttcctggg caacctgtcc ttcattgatc tcttctattc gtctgttatt gcacccaagg ccatgatcaa cttctggtct gagagcaagt ccatctcttt tgcaggctat gtgacccaat tctgtctctt taccctcttc atcgtggcag agggatttct cctggcagcc atggcctatg accgcttcat tgccatctgc aacccactcc tctactctgt gcagatgtca gcacgtctct gcactcagtt ggtggccggt tgttatttat gtggctgcat cagctcggtt cttcagacca gtatgacatt tactctgtcc ttttgtggtt ctcgggccat tgaccacttt tactgtgaca ctcgcccact tcagaggcta tcttgttctg acctcttcat ctctagaatc atttcctttt ccttatccag catcatcatc ttgcctacca tcatagttat tattatttct tacttgtata ttgtgtccac cgttctcaag atacgctcct ctgagggacg taagaaagca Page 3018

120

180

240

300

360

420

480

540

600

660

720

069269_0225_SL.TXT ttctccactt gcagctcaca cctgggagtc gtgagtgtgc tgtacggtgc tgtgtttttt atgtatctca ctcctgacag atttcctgag ctgagtaaag tggcctcttt gtgttacacc ctagtcactc ccatgttgaa tcctttgatt tactccctga gaaacaaaga tgtcaaagaa gctctaaaaa aacttctgga gaagaaaaat cctattcttt ga

780

840

900

942 <210> 2714 <211> 313 <212> PRT <213> Felis catus <400> 2714

Met Gly Asp Arg 1 Gly 5 Pro Asp Asn His Ser Glu Val Thr Asp Phe Ile 10 15 Leu Val Gly Phe Arg Val Arg Pro Glu Leu His Ile Leu Leu Phe Leu 20 25 30 Ile Phe Leu Leu Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 35 40 45 Met Thr Ile Ile Met Ala Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 65 70 75 80 Ala Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Ser Lys Ser Ile Ser 85 90 95 Phe Ala Gly Tyr Val Thr Gln Phe Cys Leu Phe Thr Leu Phe Ile Val 100 105 110 Ala Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Ser Ala Arg Leu Cys 130 135 140

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Thr Gln Leu Val Ala Gly Cys Tyr Leu Cys Gly Cys Ile Ser Ser Val 145 150 155 160 Leu Gln Thr Ser Met Thr Phe Thr Leu Ser Phe Cys Gly Ser Arg Ala 165 170 175 Ile Asp His Phe Tyr Cys Asp Thr Arg Pro Leu Gln Arg Leu Ser Cys 180 185 190 Ser Asp Leu Phe Ile Ser Arg Ile Ile Ser Phe Ser Leu Ser Ser Ile 195 200 205 Ile Ile Leu Pro Thr Ile Ile Val Ile Ile Ile Ser Tyr Leu Tyr Ile 210 215 220 Val Ser Thr Val Leu Lys Ile Arg Ser Ser Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 245 250 255 Ala Val Phe Phe Met Tyr Leu Thr Pro Asp Arg Phe Pro Glu Leu Ser 260 265 270 Lys Val Ala Ser Leu Cys Tyr Thr Leu Val Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys 290 295 300 Leu Leu Glu Lys Lys Asn Pro Ile Leu 305 310 <210> 2715 <211> 945 <212> DNA <213> Felis catus <400> 2715 atgggtgaca agggagcagg caaccactca gatgtaactg acttcattct tgtaggcttc 60

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agggttcatc cagagctcca cattctcctc ttcctcctat tcctgctggt ctatggcatg 120 gttctttttg ggaacattag tatgatgaca atcattgtga ctgactctca gctgaacaca 180 ccaatgtatt tctttctagg caatctctcc ttcattgacc tctcctactc cactgttatt 240 gccccgaaag ccatggtcaa cttcctgtct gagaaaaaga ctgtctcctt tgtggggtgt 300 gctgcccagc tcttcttttt tgccttcttc attgtaacag aagggtttgt tctggcagcc 360 atggcttatg accgtttcat cgccatttgc aaccctcttc tttacagtgt gcacatgtca 420 agacgacttt gcactcagct ggtggctggt tcctatctct gtggatggct cagttccatc 480 ctccaagtca gcacaacatt ctcagtgtct ttctgtgctt cccgagtcat tgatcacttc 540 tactgtgatt cttaccaaat tgagaagatc tcctgctcca atctctctgt caataagatg 600 gtgtctctta gtttggctgc cttcattatt ttgcctacca tagttgttat tgtagtatct 660 tacatgtaca ttgggaccac agtcttgaaa atcccttcca gtgaagggag aaggaaagcc 720 ttctccacct gcagctccca tttgggagta gtaagtttgc tctatgggac tgtctcattt 780 gtgtatctca cacctccaag caatcctgaa ctgcgtaaag tggcttcagt attttatata 840 ttggtcacac ccatgttaaa ccctctgatc tattctctaa gaaacaaaga tgtcaaacaa 900 gctttgggaa aaatcctgtg gaagaaaaaa gctttatact aattc 945 <210> 2716 <211> 313 <212> PRT <213> Felis catus <400> 2716 Met Gly Asp Lys Gly Ala Gly Asn His Ser Asp Val Thr Asp Phe Ile 1 5 10 15 Leu Val Gly Phe Arg Val His Pro Glu Leu His Ile Leu Leu Phe Leu 20 25 30 Leu Phe Leu Leu Val Tyr Gly Met Val Leu Phe Gly Asn Ile Ser Met 35 40 45 Met Thr Ile Ile Val Thr Asp Ser Gln Leu Asn Thr Pro Met Tyr Phe 50 55 60

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Phe 65 Leu Gly Asn Leu Ser Phe Ile Asp Leu Ser Tyr Ser Thr Val Ile 70 75 80 Ala Pro Lys Ala Met Val Asn Phe Leu Ser Glu Lys Lys Thr Val Ser 85 90 95 Phe Val Gly Cys Ala Ala Gln Leu Phe Phe Phe Ala Phe Phe Ile Val 100 105 110 Thr Glu Gly Phe Val Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Ser Val His Met Ser Arg Arg Leu Cys 130 135 140 Thr Gln Leu Val Ala Gly Ser Tyr Leu Cys Gly Trp Leu Ser Ser Ile 145 150 155 160 Leu Gln Val Ser Thr Thr Phe Ser Val Ser Phe Cys Ala Ser Arg Val 165 170 175 Ile Asp His Phe Tyr Cys Asp Ser Tyr Gln Ile Glu Lys Ile Ser Cys 180 185 190 Ser Asn Leu Ser Val Asn Lys Met Val Ser Leu Ser Leu Ala Ala Phe 195 200 205 Ile Ile Leu Pro Thr Ile Val Val Ile Val Val Ser Tyr Met Tyr Ile 210 215 220 Gly Thr Thr Val Leu Lys Ile Pro Ser Ser Glu Gly Arg Arg Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Leu Leu Tyr Gly 245 250 255 Thr Val Ser Phe Val Tyr Leu Thr Pro Pro Ser Asn Pro Glu Leu Arg 260 265 270

Page 3022

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Lys Val Ala Ser Val Phe Tyr Ile Leu Val Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gln Ala Leu Gly Lys 290 295 300 Ile Leu Trp Lys Lys Lys Ala Leu Tyr 305 310

<210> 2717 <211> 963 <212> DNA <213> Felis catus <400> 2717

atgagtgaca ggggaacaaa caatcactcg gaagtgactg acttcatcct tgtaggcttc 60 agggtccgct ctgagctcca cattctcctc ttcctgatct ttctgcttgt gtatgccatg 120 atcctcctag ggaatgttgg gatgatgacc attattatga ctgatccccg gctgaacaca 180 cccatgtatt tcttcctggg caacctgtcc ttcattgatc tcttctattc gtctgttatt 240 gcacccaagg ccatgatcaa cttctggtct gagagcaagt ccatctcctt tgcaggctgt 300 gtgacccagc tctttctctt tgccctcttc atcgtggcgg agggatttct cctggcagcc 360 atggcctatg accgcttcat tgccatctgc aacccactcc tctactctgt ccagatgaca 420 gcacatctct gcacgcagtt ggtggctggt tcctatattt gtggctgctt tagctcaatt 480 cttttgacca gcgtgacatt tactctgtcc ttttgtgctt cccgagccat cgaccacttt 540 tactgtgatt accgtccact tcaaaggatt tcttgttctg atatctactt tcttaaggtg 600 gtttcttttt tcttatgcag cattattatt ttgcctacca taattgtcat tattgtgtcc 660 tatatgtata ttgtgtccac ggttttaaag ataaaatcct ctgaaggacg taagaaagcc 720 ttctccactt gcagttcaca cctgggagtc gtgagtgtgt tgtacggtgc tgtgattttt 780 atgtatttca tccctgatag atttcctgag ctgagtaaag tggcctcatt atgttacacc 840 ctagtcactc ccatgctgaa tcctttgatt tactccctga taaacaaaga tgtcaaagaa 900 gctttgagaa agattctagg gaaaaaaata cttttatttc attctatctt aacagtgaca 960

taa 963

Page 3023

069269_0225_SL.TXT <210> 2718 <211> 320 <212> PRT <213> Felis catus

<400> 2718 Met 1 Ser Asp Arg Gly 5 Thr Asn Asn His Ser Glu Val Thr Asp Phe Ile 10 15 Leu Val Gly Phe Arg Val Arg Ser Glu Leu His Ile Leu Leu Phe Leu 20 25 30 Ile Phe Leu Leu Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 35 40 45 Met Thr Ile Ile Met Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 65 70 75 80 Ala Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Ser Lys Ser Ile Ser 85 90 95 Phe Ala Gly Cys Val Thr Gln Leu Phe Leu Phe Ala Leu Phe Ile Val 100 105 110 Ala Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Thr Ala His Leu Cys 130 135 140 Thr Gln Leu Val Ala Gly Ser Tyr Ile Cys Gly Cys Phe Ser Ser Ile 145 150 155 160 Leu Leu Thr Ser Val Thr Phe Thr Leu Ser Phe Cys Ala Ser Arg Ala 165 170 175

Page 3024

Ile Asp His Phe 180 Tyr Cys Asp 069269_0225_SL.TXT Tyr Arg Pro Leu Gln Arg 185 Ile 190 Ser Cys Ser Asp Ile Tyr Phe Leu Lys Val Val Ser Phe Phe Leu Cys Ser Ile 195 200 205 Ile Ile Leu Pro Thr Ile Ile Val Ile Ile Val Ser Tyr Met Tyr Ile 210 215 220 Val Ser Thr Val Leu Lys Ile Lys Ser Ser Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 245 250 255 Ala Val Ile Phe Met Tyr Phe Ile Pro Asp Arg Phe Pro Glu Leu Ser 260 265 270 Lys Val Ala Ser Leu Cys Tyr Thr Leu Val Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Ile Asn Lys Asp Val Lys Glu Ala Leu Arg Lys 290 295 300 Ile Leu Gly Lys Lys Ile Leu Leu Phe His Ser Ile Leu Thr Val Thr 305 310 315 320

<210> 2719 <211> 952 <212> DNA <213> Felis <400> 2719 tcaaagaata ttctcaggga ccactttact acaacacact cagaggagcg catus ggatttttct gtaaatcaaa cagctcagga cacgactccc tatcttgaga tctctagaag ggattcagca aatctgtcag aggtgtgaac actgtggcca ttttttttag tgggagtgac ggatgacata tgcaagtgga tgatatacaa agcttctttg tagggtgtaa cataaaaatc gaacgctttc gtaagaaata acatctttgt cacaaagagg atggcaccgt ttacgtccct ataataacta

120

180

240

300

Page 3025

069269_0225_SL.TXT

tgatggtagg caagatgatg atgctggata aggaaaagga aatgattcta gagatgaaga 360 ggtcagaaca agatagcctc tgaagtgggc gtgtgtcaca gtaaaagtgg tcaatggccc 420 gagaaccaca aaaggacaga gtaaatgtca tactggtctg aactgagtat ggtctgaact 480 gagctgatgc agccacataa ataggaactg gccaccaact gcgtgcagag acgtgctgac 540 atctggacag agtagaggag tgggttgcag atggcaatga agcggtcata ggccatggct 600 gccaggagaa atccctccgc caccatgaag agggcaaaga gaaagagctg ggtcacacag 660 cctgctaaag agatggactt gctctcagac cagaagttga tcatggcctt gggtgcaata 720 acagacgaat agaagagatc aatgaaggac aggttgccca ggaagaaata catgggtgtg 780 ttcagccggg gatcggccat aataatggtt atcatcccaa cattccctag gaggatcatg 840 gcatacacaa gcagaaagat caggaagagg agaatgtgga gctctgggtg ggctctgaac 900 cgtacaagaa tgaagttagt tacttcagag tcattgttcc tctgtcaccc at 952

<210> 2720 <211> 197 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (197)..(197) <223> Any amino acid

<400> 2720 Met Thr Ala Ser 1 Leu 5 Pro Ser Ala Thr His Ser Ser Thr Leu Ser Arg 10 15 Cys Gln His Val Ser Ala Arg Ser Trp Trp Pro Val Pro Ile Tyr Val 20 25 30 Ala Ala Ser Ala Gln Phe Arg Pro Tyr Ser Val Gln Thr Ser Met Thr 35 40 45 Phe Thr Leu Ser Phe Cys Gly Ser Arg Ala Ile Asp His Phe Tyr Cys 50 55 60 Asp Thr Arg Pro Leu Gln Arg Leu Ser Cys Ser Asp Leu Phe Ile Ser Page 3026

069269_0225_SL.TXT

65 70 75 80 Arg Ile Ile Ser Phe Ser Leu Ser Ser Ile Ile Ile Leu Pro Thr Ile 85 90 95 Ile Val Ile Ile Ile Ser Tyr Leu Tyr Ile Met Ala Thr Val Leu Lys 100 105 110 Ile Arg Ser Ser Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser 115 120 125 His Leu Gly Val Val Ser Val Leu Tyr Gly Ala Met Ile Phe Met Tyr 130 135 140 Val Ile Pro Asp Arg Phe Pro Glu Leu Ser Lys Val Ala Ser Leu Cys 145 150 155 160 Tyr Thr Leu Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg 165 170 175 Asn Lys Asp Val Lys Glu Ala Leu Lys Lys Thr Ser Arg Glu Glu Lys 180 185 190 Ser Tyr Ser Leu Xaa

195 <210> 2721 <211> 963 <212> DNA <213> Felis catus <400> 2721

ttatgtcact gctaagatag aattaaacaa aaatattttt ttccccagac tctttctcaa 60 agcttctttg acatctttgt ttcttagaga gtaaatcaaa ggattcagca tgggagtgac 120 tagggtgtaa cacaacgagg caactttact cagctcagga aatctgtcag gagtgagata 180 cataaaaaac acagcaccgt acagcacact cacgactccc aggtgtgagc tgcaagtgga 240 gaatgctttc ttacgtccct cagaggagcg tatcttgaga actgtggaca caatatacaa 300 gtaagaaata ataataacta tgatggtagg caagatgatg atgctgcata aggaaaagga 360

Page 3027

069269_0225_SL.TXT

aatgattcta gagatgaaga ggtcagagca agatatcctc tcaagtgggc gagtgtcaca 420 gtaaaagtgg tcaatggccc gagagccaca aaaggacaga gtaaatgtca tactggtctg 480 aagaaccgag ctgatgcagc cacataaata ggaaccagcc accaactgag tgcagagacg 540 tgctgacatc tggacagagt agaggagtgg gttgcagatg gcaatgaagc ggtcataggc 600 catggctgcc aggagaaatc cctctgccac gatgaagagg gtaaagagac agaattgggt 660 cacacagcct gcaaaagaga tggacttgct ctcagaccag aagttgatca tggccttggg 720 tgcaataaca gatgaataga agagatcaat gaaggacaga ttgcctagga agaaatacat 780 gggtgtgttc agccggggat cagtcataat aatggtcatc atcccaacat tacccagaag 840 gatcatggcg tacacaagca gaaagatcag gaagaggaga atgtggagct cggagctgac 900 cctgaagcct accaggatga agtcagtcac ttcagagtga ttgtttgttc ctctgtcact 960

cat 963 <210> 2722 <211> 320 <212> PRT <213> Felis catus

<400> 2722 Gly Thr 5 Asn Asn His Ser Glu Val Thr Asp Phe Ile Met Ser 1 Asp Arg 10 15 Leu Val Gly Phe Arg Val Ser Ser Glu Leu His Ile Leu Leu Phe Leu 20 25 30 Ile Phe Leu Leu Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 35 40 45 Met Thr Ile Ile Met Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 65 70 75 80 Ala Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Ser Lys Ser Ile Ser 85 90 95

Page 3028

069269_0225_SL.TXT

Phe Ala Gly Cys Val Thr Gln Phe Cys Leu Phe Thr Leu Phe 110 Ile Val 100 105 Ala Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Ser Ala Arg Leu Cys 130 135 140 Thr Gln Leu Val Ala Gly Ser Tyr Leu Cys Gly Cys Ile Ser Ser Val 145 150 155 160 Leu Gln Thr Ser Met Thr Phe Thr Leu Ser Phe Cys Gly Ser Arg Ala 165 170 175 Ile Asp His Phe Tyr Cys Asp Thr Arg Pro Leu Glu Arg Ile Ser Cys 180 185 190 Ser Asp Leu Phe Ile Ser Arg Ile Ile Ser Phe Ser Leu Cys Ser Ile 195 200 205 Ile Ile Leu Pro Thr Ile Ile Val Ile Ile Ile Ser Tyr Leu Tyr Ile 210 215 220 Val Ser Thr Val Leu Lys Ile Arg Ser Ser Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 245 250 255 Ala Val Phe Phe Met Tyr Leu Thr Pro Asp Arg Phe Pro Glu Leu Ser 260 265 270 Lys Val Ala Ser Leu Cys Tyr Thr Leu Val Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys 290 295 300

Page 3029

069269_0225_SL.TXT

Ser Leu Gly Lys Lys Ile Phe Leu Phe Asn Ser Ile Leu Ala Val Thr 305 310 315 320 <210> 2723 <211> 963 <212> DNA <213> Felis catus <400> 2723

ttatgtcact gttaagatag aattaagtaa aagtattttt ttccccagaa tctttctcag 60 agcttctttg acatctttgt ttctcagaga gtaaatcaaa ggattcagca tgggagtgac 120 tagggtgtaa cacaacgagg ccactttact cagctcagga aatctgtcag gagtgagata 180 cataaaaaac acagcaccgt acagcacact cacgactccc aggtgtgagc tgcaagtgga 240 gaatgctttc ttacgtccct cagaggagcg tatcttgaga actgtggaca caatatacaa 300 gtaagaaata ataataacta tgatggtagg caagatgatg atgcttgata agaaaaagga 360 aatcatccta tagatgaaga agtcagaaca agatatcctc tcaagtgggc gagtgtcaca 420 gtaaaagtgg tcaatggccc gagagccaca aaaggacaga gtaaatacca tgcttgtctg 480 aagaaccgag ctaatgcagc cacagatata agaaccagcc accaactgaa tgcaaagacg 540 tgttgacatc tgggaagagt agaggagtgg gttgcagatg gcaatgaagc ggtcataggc 600 catagctgcc aggagaaatc cctccgccac gatgaagagg gcaaagagaa agagctgggt 660 cacacagcct gcaaaggaga tggacttgct ctcagaccag aagttgatca tggccttggg 720 tgcaataaca gacgaataga agagatcaat gaaggacagg ttgcctagga agaaatacat 780 cggtgtgttc agccggggat cagtaataat aatggtcatc atcccaacat tccctaggag 840 gatcatggca tacacaagca gaaagatcag gaagaggaga atgtggagct cagggcggac 900 cctgaagcct acaaggatga agtcagtcac ttccgagtga ttgtctgttc ccctgtcacc 960

cat 963 <210> 2724 <211> 320 <212> PRT <213> Felis catus

Page 3030

069269_0225_SL.TXT

<400> 2724 Gly Thr Asp Asn His Ser Glu Val Thr Asp Phe 15 Ile Met 1 Gly Asp Arg 5 10 Leu Val Gly Phe Arg Val Arg Pro Glu Leu His Ile Leu Leu Phe Leu 20 25 30 Ile Phe Leu Leu Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 35 40 45 Met Thr Ile Ile Ile Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 65 70 75 80 Ala Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Ser Lys Ser Ile Ser 85 90 95 Phe Ala Gly Cys Val Thr Gln Leu Phe Leu Phe Ala Leu Phe Ile Val 100 105 110 Ala Glu Gly Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Ser Ser Gln Met Ser Thr Arg Leu Cys 130 135 140 Ile Gln Leu Val Ala Gly Ser Tyr Ile Cys Gly Cys Ile Ser Ser Val 145 150 155 160 Leu Gln Thr Ser Met Val Phe Thr Leu Ser Phe Cys Gly Ser Arg Ala 165 170 175 Ile Asp His Phe Tyr Cys Asp Thr Arg Pro Leu Glu Arg Ile Ser Cys 180 185 190 Ser Asp Phe Phe Ile Tyr Arg Met Ile Ser Phe Phe Leu Ser Ser Ile 195 200 205

Page 3031

069269_0225_SL.TXT

Ile Ile Leu Pro Thr Ile Ile Val Ile Ile Ile Ser Tyr Leu Tyr Ile 210 215 220 Val Ser Thr Val Leu Lys Ile Arg Ser Ser Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 245 250 255 Ala Val Phe Phe Met Tyr Leu Thr Pro Asp Arg Phe Pro Glu Leu Ser 260 265 270 Lys Val Ala Ser Leu Cys Tyr Thr Leu Val Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys 290 295 300 Ile Leu Gly Lys Lys Ile Leu Leu Leu Asn Ser Ile Leu Thr Val Thr 305 310 315 320

<210> 2725 <211> 939 <212> DNA <213> Felis catus <400> 2725 tcatttatat aaagaaaaga ccattctctg gaccatgttc ttgaaggctt gctttacctg 60 ctgattcctt agtgaatata tgaaaggatt caggagagga gcaactgagg taatgattac 120 agctacccct ttgtttaaag tcaccctttc ccttgcagaa ggcttaatgt acatgaagat 180 gcagcttcca taagagaggg agaccactat catgtgggag gaacaagtgg aaaaggcttt 240 tttcctttga ctcttggaag gaattttcag aattgtccgg atgatgtacg tataggagag 300 cataactagt gttaaggtga ccataagtgt taccactgct aaaataaatg ccatgagttc 360 taaaaagcga gtgtttgtac aggaaagctg tagaatcgga gaagagtcgc agataaaatg 420 atcaattaca ttggaggcac agaactccaa cttctgcagc agaattactg gtggaaagat 480 gatcaggaat cctgcaagcc atgagctaaa gacaaggagt atgcagactc tgtgattcat 540

Page 3032

069269_0225_SL.TXT

gatggtcatg taatggagag gcttgcagat ggccacgtag cggtcatagg acatggcagc 600 cagaaggtaa aattctgtca cccccaacag gatgaagaaa aataactgag ccacacaatc 660 attgtaggaa atagttctgt ttcccgtcac tatagtgaca aggaatctgg ggatgcagac 720 agatgtgaat gataattctg ggaatgagaa gtttcgaagg aagaaataca ttggagtctt 780 taagtgggga tctgaaagtg tgagaatgat aacgatcagg ttcccagtca cactaagcat 840 gtaggtagca agaagaaata cgaaaagtac aacctgccat tgtgggtcat ttgtcaatcc 900 gagaagaata aattctgtta ctgctgtgta atttctcat 939

<210> 2726 <211> 312 <212> PRT <213> Felis catus

<400> 2726 Ala Val Thr Glu Phe Ile Leu Leu Gly Leu Thr Met 1 Arg Asn Tyr Thr 5 10 15 Asn Asp Pro Gln Trp Gln Val Val Leu Phe Val Phe Leu Leu Ala Thr 20 25 30 Tyr Met Leu Ser Val Thr Gly Asn Leu Ile Val Ile Ile Leu Thr Leu 35 40 45 Ser Asp Pro His Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Pro Glu Leu Ser Phe Thr Ser Val Cys Ile Pro Arg Phe Leu 65 70 75 80 Val Thr Ile Val Thr Gly Asn Arg Thr Ile Ser Tyr Asn Asp Cys Val 85 90 95 Ala Gln Leu Phe Phe Phe Ile Leu Leu Gly Val Thr Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125

Page 3033

069269_0225_SL.TXT

His Tyr 130 Met Thr Ile Met Asn His Arg Val Cys Ile Leu Leu Val Phe 135 140 Ser Ser Trp Leu Ala Gly Phe Leu Ile Ile Phe Pro Pro Val Ile Leu 145 150 155 160 Leu Gln Lys Leu Glu Phe Cys Ala Ser Asn Val Ile Asp His Phe Ile 165 170 175 Cys Asp Ser Ser Pro Ile Leu Gln Leu Ser Cys Thr Asn Thr Arg Phe 180 185 190 Leu Glu Leu Met Ala Phe Ile Leu Ala Val Val Thr Leu Met Val Thr 195 200 205 Leu Thr Leu Val Met Leu Ser Tyr Thr Tyr Ile Ile Arg Thr Ile Leu 210 215 220 Lys Ile Pro Ser Lys Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Val Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Lys Pro Ser Ala Arg Glu Arg Val Thr Leu Asn Lys Gly Val 260 265 270 Ala Val Ile Ile Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asn Met Val Gln 290 295 300 Arg Met Val Phe Ser Leu Tyr Lys

305 310 <210> 2727 <211> 937

Page 3034

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 2727

atgggtggta agggaggaga caaccactca gaagtgactg acttcattct tgtaggcttc 60 agggtccgtc caaagctcca cagtctcctc ttcctactat tcctggttgt ttatgggatg 120 gtccttctgg ggaaccttat tatgattggc atcattgtga ccgatccccg gctgaacaca 180 ccaatgtatt tcttcgtagg caatctctcc atcattgacc tctcctactc cactgttatt 240 gtacccaaag ccatggtcaa catcctatct cagaaaaaga ccatatcctt tgaacgttgt 300 gtgactcaat tgtttcttta tgcatttttc atggtcaccg aggcctctgt cttggcagcc 360 atggcctatg accgcttcat cgccatctgc aatccactcc tctacactgt ccgcatgtca 420 agaagcctct gtatccagtt ggtggctggt tcctatctct gtggctgggt cagttccatc 480 cttcaaatca gtgtaacatt ctcaatgtct ttctgtgctt cccgagtcat tgatcacttc 540 tattgtgatt caaacccagt tgagaagatc tcctgttcca atatctttat gaataagatg 600 gtgtcgttca gtctgactgt cctcattatt ttgcccacaa tagttgttat tgtggtatgt 660 tacatgtata ttgtgtctgt agttttaaag atgcactcca gtgaagggag gaagagagcc 720 ttctccactt gcagttacca cctggggatc gtaagtttgc tctgagacta tttcctttgt 780 caatttcaca cctcccaata accttaaact ttgtaaagtg gcttcagtat gttacatttt 840 gttcacacct atgctgaacc ctttaatcta ctctgagaaa taagggtgtt aaagatgcca 900 tgagaaaagt cctatggaag aaaaagtttt actttaa 937

<210> 2728 <211> 254 <212> PRT <213> Felis catus

<400> 2728 Met Gly Gly Lys Gly Gly Asp Asn His Ser Glu Val Thr Asp Phe Ile 1 5 10 15 Leu Val Gly Phe Arg Val Arg Pro Lys Leu His Ser Leu Leu Phe Leu 20 25 30 Leu Phe Leu Val Val Tyr Gly Met Val Leu Leu Gly Asn Leu Ile Met Page 303 5

069269_0225_SL.TXT 40 45

Ile Gly Ile Ile Val Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Val Gly Asn Leu Ser Ile Ile Asp Leu Ser Tyr Ser Thr Val Ile 65 70 75 80 Val Pro Lys Ala Met Val Asn Ile Leu Ser Gln Lys Lys Thr Ile Ser 85 90 95 Phe Glu Arg Cys Val Thr Gln Leu Phe Leu Tyr Ala Phe Phe Met Val 100 105 110 Thr Glu Ala Ser Val Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Thr Val Arg Met Ser Arg Ser Leu Cys 130 135 140 Ile Gln Leu Val Ala Gly Ser Tyr Leu Cys Gly Trp Val Ser Ser Ile 145 150 155 160 Leu Gln Ile Ser Val Thr Phe Ser Met Ser Phe Cys Ala Ser Arg Val 165 170 175 Ile Asp His Phe Tyr Cys Asp Ser Asn Pro Val Glu Lys Ile Ser Cys 180 185 190 Ser Asn Ile Phe Met Asn Lys Met Val Ser Phe Ser Leu Thr Val Leu 195 200 205 Ile Ile Leu Pro Thr Ile Val Val Ile Val Val Cys Tyr Met Tyr Ile 210 215 220 Val Ser Val Val Leu Lys Met His Ser Ser Glu Gly Arg Lys Arg Ala 225 230 235 240 Phe Ser Thr Cys Ser Tyr His Leu Gly Ile Val Ser Leu Leu

Page 3036

069269_0225_SL.TXT 245 250 <210> 2729 <211> 930 <212> DNA <213> Felis catus <400> 2729

atgggtgaca ggggaacaga caatcattcg gaagtaactg acttcatcct tgtaggcttc 60 agggtccgct ccgagctcca cattctcctc ttcctgatct ttctgcttgt gtatgccatg 120 atcctcctag ggaatgttgg gatgatgacc attattatga ctgatccccg gctgaacaca 180 cccatgtatt tcttcctggg caacctgtcc ttcattgatc tcttctattc gtctgttatt 240 gcacccaagg ccatgatcaa cttctggtct gagggcaagt ccatctcttt tgcaggctgt 300 gtgacccagt tctgtctttt tgccctcttc atggtggcag agggatttct cctgggagcc 360 atggcctatg accgcttcat tgccatctgc aacccacttc tctactctgt ccagatgtca 420 gcacgtctct gcactcagtt ggtggctggt tcctatttat gcggctgcat cagctcagtt 480 cttcagacaa gcacgacatt tactttgcca ttttgtggtt ctcgggccat tgaccacttt 540 ttctgtgata ttcgcccact tcagagacta tcttgttctg acctcttcat ctatagaatg 600 atttcttttt ccttatccag catcattacc ttgcctacaa taattgtcat tattgtgtcc 660 tatatgtata ttgtatccac agtactaaag atacgctcct ctgagggacg taagaaagcg 720 ttctccactt gtagctctca cctaggagtc gtgagtgtgc tgtacggtgc tgtgtttttt 780 acatatctca ctccggacag atttcctgag ctgagtaaag tgacctcctt atgctatacc 840 ttagtcactc ccatgttgaa tcctttgatt tactctctga gaaacaaaga tgtcaaagag 900 gctctaaaaa aacttttaga gatgaaaaat 930

<210> 2730 <211> 310 <212> PRT <213> Felis catus <400> 2730

Met Gly Asp Arg Gly Thr Asp Asn His Ser Glu Val Thr Asp Phe Ile 1 5 10 15

Page 3037

069269_0225_SL.TXT

Leu Val Gly Phe 20 Arg Val Arg Ser Glu Leu His Ile Leu Leu Phe Leu 25 30 Ile Phe Leu Leu Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 35 40 45 Met Thr Ile Ile Met Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 65 70 75 80 Ala Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Gly Lys Ser Ile Ser 85 90 95 Phe Ala Gly Cys Val Thr Gln Phe Cys Leu Phe Ala Leu Phe Met Val 100 105 110 Ala Glu Gly Phe Leu Leu Gly Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125 Ile Cys Asn Pro Leu Leu Tyr Ser Val Gln Met Ser Ala Arg Leu Cys 130 135 140 Thr Gln Leu Val Ala Gly Ser Tyr Leu Cys Gly Cys Ile Ser Ser Val 145 150 155 160 Leu Gln Thr Ser Thr Thr Phe Thr Leu Pro Phe Cys Gly Ser Arg Ala 165 170 175 Ile Asp His Phe Phe Cys Asp Ile Arg Pro Leu Gln Arg Leu Ser Cys 180 185 190 Ser Asp Leu Phe Ile Tyr Arg Met Ile Ser Phe Ser Leu Ser Ser Ile 195 200 205 Ile Thr Leu Pro Thr Ile Ile Val Ile Ile Val Ser Tyr Met Tyr Ile 210 215 220

Page 3038

Val 225 Ser Thr Val Leu Lys 230 Ile 069269_0225_SL.TXT Arg Ser Ser Glu Gly Arg 235 Lys Lys Ala 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 245 250 255 Ala Val Phe Phe Thr Tyr Leu Thr Pro Asp Arg Phe Pro Glu Leu Ser 260 265 270 Lys Val Thr Ser Leu Cys Tyr Thr Leu Val Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys 290 295 300 Leu Leu Glu Met Lys Asn 305 310

<210> 2731 <211> 963 <212> DNA <213> Felis catus <400> 2731

ttatgtcact gttaagatag aattaaataa aataattttt ttccccagaa tctttctcaa 60 agcttctttg acatctttgt ttctcaggga gtaaatcaaa ggattcagca tgggagtgac 120 tagggtgtaa cacaaagagg ccactttact cagctcagga aatctgtcag ggatgacata 180 cataaaaatc acagcaccat acagcacact cacgactccc aggtgagagc tgcaagtgga 240 aaacgctttc ttacgtccct cagtggatct tatctttaaa accgtggaca caatatacat 300 ataggaaaca ataatgacaa ttatggtagg caaaataata atgctgcata agaaaaacgt 360 aaccatgtta tgaaagtaga gatcagaaca agatagcctc tgaagtggac ggtcatcaca 420 gtaaaagtgg tcaatggttc gggaagcaca aaaggacaaa gtaaatgtta tgcttgtctg 480 aagaaccgag ctgatgcagc cacataaata gcaaccagcc accaactgag tgcaaagact 540 tgctgacatc tgcacagagt agaggagtgg gttgcagatg gcaatgaagc ggtcataggc 600 catggctgcc aggagaaatg cctccgccac gatgaagagg gcaaagagaa agagctgggt 660

Page 3039

069269_0225_SL.TXT cacacagcct gctaaagaga tggacttgct ctcagaccag aagttgatca tggccttggg tgcaataaca gatgaataga agagatcaat gaaggacagg ttgcccagga agaaatacat gggtgtgttc agccggggat cagtcataat aatggtcatc atcccaacat tccctaggag gatcatggca tacacaagca gaaagatcag gaagaggaga atgtggagct cagagcggac tctgaagcct acaaggatga agtcagtcac ttccgaatga ttgtctgttc ccctgtcacc cat

720

780

840

900

960

963 <210> 2732 <211> 320 <212> PRT <213> Felis catus

<400> 2732 Thr Asp Asn His Ser Glu Val Thr Asp Phe Ile Met 1 Gly Asp Arg Gly 5 10 15 Leu Val Gly Phe Arg Val Arg Ser Glu Leu His Ile Leu Leu Phe Leu 20 25 30 Ile Phe Leu Leu Val Tyr Ala Met Ile Leu Leu Gly Asn Val Gly Met 35 40 45 Met Thr Ile Ile Met Thr Asp Pro Arg Leu Asn Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser Ser Val Ile 65 70 75 80 Ala Pro Lys Ala Met Ile Asn Phe Trp Ser Glu Ser Lys Ser Ile Ser 85 90 95 Leu Ala Gly Cys Val Thr Gln Leu Phe Leu Phe Ala Leu Phe Ile Val 100 105 110 Ala Glu Ala Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Phe Ile Ala 115 120 125

Ile Cys Asn Pro Leu

Leu

Tyr Ser Val Gln

Met Ser Ala Ser Leu

Cys

Page 3040

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130 135 140 Thr Gln Leu Val Ala Gly Cys Tyr Leu Cys Gly Cys Ile Ser Ser Val 145 150 155 160 Leu Gln Thr Ser Ile Thr Phe Thr Leu Ser Phe Cys Ala Ser Arg Thr 165 170 175 Ile Asp His Phe Tyr Cys Asp Asp Arg Pro Leu Gln Arg Leu Ser Cys 180 185 190 Ser Asp Leu Tyr Phe His Asn Met Val Thr Phe Phe Leu Cys Ser Ile 195 200 205 Ile Ile Leu Pro Thr Ile Ile Val Ile Ile Val Ser Tyr Met Tyr Ile 210 215 220 Val Ser Thr Val Leu Lys Ile Arg Ser Thr Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Gly Val Val Ser Val Leu Tyr Gly 245 250 255 Ala Val Ile Phe Met Tyr Val Ile Pro Asp Arg Phe Pro Glu Leu Ser 260 265 270 Lys Val Ala Ser Leu Cys Tyr Thr Leu Val Thr Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys 290 295 300 Ile Leu Gly Lys Lys Ile Ile Leu Phe Asn Ser Ile Leu Thr Val Thr 305 310 315 320

<210> 2733 <211> 920 <212> DNA <213> Felis catus

Page 3041

069269_0225_SL.TXT agcctaacag caaaagtaca gaaatattag tcttccttag ccttagccaa ttttcttctt atcgattctc gtgctcagtt gtttcacctt tcccagccct ttctctctgc tcctgtccac gtggctccca agcctggggc taataccgat tgaaaagaat gaattactca gatcctctta catgataatt aaacttgtct cttcctatct tgccctgttt ggccatttgc ggtgactgga cagtttgcgt gatcaagatc tctcatcatc cgtcctgaag tatagcagtg tatctcctct gctaaaccct <400> 2733 atgaagagcg ataacccctc actgtggtgg cctatgtatt gctcccaaaa gcagcccaat atggcatttg cagaaagtct gttcaaacag ttctgtgacg gtgctgtaca tatgcttaca ttctccacct atgtatgccc tacacactgg caagaggcta <210> 2734 <211> 307 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (307)..(307) <223> Any amino acid <400> 2734

Met Lys Ser Glu Pro Asn Arg Asn Tyr 1 5

gaagtgactg agtttgttct actaggattc 60 ttcctagtgt tcttgctgat ctacatggtc 120 gtcattaagg tggactccag acttcatatg 180 tatttagatc tctgctactc cacagtcatt 240 aagggaaaga agatttctta caatggctgc 300 gtcacaactg aaggctttct tctggctgtc 360 tcccctctcc tttaccccgt gcacatgtcc 420 tcctacatct gtggaggcat caactccatg 480 ttctgtggag aaaacagact agaccacttt 540 tcctgtgcgg acacatctgt gaatgagatt 600 atcaccacca caactgtcat tgtggtttcc 660 atcccctcga cccatggcag gggtaagacc 720 gtgagtttat tctatggggc tgtattcttc 780 ccagagtcaa acaagattgt agctgtgctg 840 ctaatataca gtctgagaaa cagagatgtg 900

920

Leu Leu Gly Phe Ile Thr Pro Pro Lys 20 25

Ser Glu Val Thr Glu Phe Val 10 15 Val Gln Ile Leu Leu Phe Leu

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Val Phe Leu 35 Leu Ile Tyr Met Val Thr Val Val Gly Asn Ile Ser Met 40 45 Ile Ile Val Ile Lys Val Asp Ser Arg Leu His Met Pro Met Tyr Phe 50 55 60 Phe Leu Arg Asn Leu Ser Tyr Leu Asp Leu Cys Tyr Ser Thr Val Ile 65 70 75 80 Ala Pro Lys Thr Leu Ala Asn Phe Leu Ser Lys Gly Lys Lys Ile Ser 85 90 95 Tyr Asn Gly Cys Ala Ala Gln Phe Phe Phe Phe Ala Leu Phe Val Thr 100 105 110 Thr Glu Gly Phe Leu Leu Ala Val Met Ala Phe Asp Arg Phe Ser Ala 115 120 125 Ile Cys Ser Pro Leu Leu Tyr Pro Val His Met Ser Gln Lys Val Cys 130 135 140 Ala Gln Leu Val Thr Gly Ser Tyr Ile Cys Gly Gly Ile Asn Ser Met 145 150 155 160 Val Gln Thr Gly Phe Thr Phe Ser Leu Arg Phe Cys Gly Glu Asn Arg 165 170 175 Leu Asp His Phe Phe Cys Asp Val Pro Ala Leu Ile Lys Ile Ser Cys 180 185 190 Ala Asp Thr Ser Val Asn Glu Ile Val Leu Tyr Ile Leu Ser Ala Leu 195 200 205 Ile Ile Ile Thr Thr Thr Thr Val Ile Val Val Ser Tyr Ala Tyr Ile 210 215 220 Leu Ser Thr Val Leu Lys Ile Pro Ser Thr His Gly Arg Gly Lys Thr 225 230 235 240

Page 3043

069269_0225_SL.TXT

Phe Ser Thr Cys Gly Ser His Ile Ala Val Val Ser Leu Phe Tyr Gly 245 250 255 Ala Val Phe Phe Met Tyr Ala Gln Pro Gly Ala Ile Ser Ser Pro Glu 260 265 270 Ser Asn Lys Ile Val Ala Val Leu Tyr Thr Leu Val Ile Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Arg Asp Val Gln Glu Ala Met 290 295 300

Lys Arg Xaa

305 <210> 2735 <211> 831 <212> DNA <213> Felis catus <400> 2735 atgaagaaag agctgaatag gaattactca gaactgacag agtttattct gctgggattc agaacatctc cagatgtaca gattttttta ttcttattct tcttgcttat ctacatggtc attgtggtgg gaaatatcag catgataatt gtcattaaaa tagactccag acttcatacg cctatgtatt tctttctcag aaatttgtcc tatttagatc tctgctactc cacagtcatt gctcccaaaa ctctggctac tttcttgtcc acggacaaga aaatttccta caatggctgt gcaacacaat tctttttctt cgctcttttt gttgggactg aaggctttct tctagccgtg atggcatatg atcgcttctc agccatttgc tcgcccttcc tctatactgt acatatgtct cagcaggctt gtattcgttt agtgtttggc tcctatatct gtggaggcat caactccatg gtccaaacag gtttcacctt cagtttgcat ttctgtggag aaaacagact agaccacttt ttctgtgacg tcccagccct gatcaagatc tcatgtgctg acacgtctgt gaatgagatt gtgctgtaca ttctctctgc tctcatcatc atcaccacca caactgtcat tgtggtttcc tatgcttaca tcctgtccac cgtcctgaag atcccctcga cccatggcag gggtaagacc

120

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Page 3044

780

831

069269_0225_SL.TXT ttctccactt gcagctctca cattactgtg gtgagcttat tctatgggac ggtgttcttc atgtatgccc agcctggggc catctcctca ccacagaaaa gcaagataat a <210> 2736 <211> 277 <212> PRT <213> Felis catus <400> 2736

Met 1 Lys Lys Glu Leu 5 Asn Arg Asn Tyr Ser 10 Glu Leu Thr Glu Phe 15 Ile Leu Leu Gly Phe Arg Thr Ser Pro Asp Val Gln Ile Phe Leu Phe Leu 20 25 30 Phe Phe Leu Leu Ile Tyr Met Val Ile Val Val Gly Asn Ile Ser Met 35 40 45 Ile Ile Val Ile Lys Ile Asp Ser Arg Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Arg Asn Leu Ser Tyr Leu Asp Leu Cys Tyr Ser Thr Val Ile 65 70 75 80 Ala Pro Lys Thr Leu Ala Thr Phe Leu Ser Thr Asp Lys Lys Ile Ser 85 90 95 Tyr Asn Gly Cys Ala Thr Gln Phe Phe Phe Phe Ala Leu Phe Val Gly 100 105 110 Thr Glu Gly Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Ser Ala 115 120 125 Ile Cys Ser Pro Phe Leu Tyr Thr Val His Met Ser Gln Gln Ala Cys 130 135 140 Ile Arg Leu Val Phe Gly Ser Tyr Ile Cys Gly Gly Ile Asn Ser Met 145 150 155 160 Val Gln Thr Gly Phe Thr Phe Ser Leu His Phe Cys Gly Glu Asn Arg

Page 3045

165

175

069269_0225_SL.TXT

170

Leu Asp His Phe Phe Cys Asp Val Pro Ala Leu Ile Lys Ile Ser Cys 180 185 190 Ala Asp Thr Ser Val Asn Glu Ile Val Leu Tyr Ile Leu Ser Ala Leu 195 200 205 Ile Ile Ile Thr Thr Thr Thr Val Ile Val Val Ser Tyr Ala Tyr Ile 210 215 220 Leu Ser Thr Val Leu Lys Ile Pro Ser Thr His Gly Arg Gly Lys Thr 225 230 235 240 Phe Ser Thr Cys Ser Ser His Ile Thr Val Val Ser Leu Phe Tyr Gly 245 250 255 Thr Val Phe Phe Met Tyr Ala Gln Pro Gly Ala Ile Ser Ser Pro Gln 260 265 270 Lys Ser Lys Ile Ile 275

<210> 2737 <211> 951 <212> DNA <213> Felis catus <400> 2737

atgatttgtg aaaatcacac cagagtcact gaatttcttc ttctcggttt tacaaataac 60 cctgagatgc aagtttccct ctttattttg ttcctggtca tctatacagt cactttgttg 120 ggcaacttcc ttatcgtcac agttaccagt gtggatcctg ctcttcaaac acccatgtac 180 ttctttctcc gaaacctatc acttctcgaa gtctgtttta ccttggtcat ggtgccgaag 240 atgctggtag atctagtgtc tccaaggaaa gtcatctctt ttgtaggctg tggtgcccag 300 atgtactttt tcttcttctt tggcagctct gaatgttttc ttctgtctat gatggcttat 360 gatcgctttg tggccatctg taaccctctc cgttattcag tcataatgaa taggtccctg 420 tgcttgtgga tggctgtcgg ctcttggatg tctggtgttc ctgtctctat gctacaaaca 480

Page 3046

069269_0225_SL.TXT

gcttggttga tggcccttcc tttctgtgga ccaaatacca tagaccactt tttttgtgat 540 ggtcctccgg tgttgaaact agtcactcag gatacaagca tgtatgaaat gcaagcactt 600 gcctccacac tactgtttat tatgtttcct ttttccctca ttttggtctc ctacatccgc 660 attatcacaa ctgtcctcag gatgccatct gctactggtc gccagaaggc attctccacc 720 tgttcgtcac acctcattgt ggtatccctt ttctatggaa ccgccagcct gacctaccta 780 cggcccaaat ccagccagtc ccctgaaagc aagaagctag tgtcattgtc atacactgtc 840 atcactccta tgttaaatcc gatcatctac agcctaagga acaatgaagt gaagggggct 900 gtcaagagga cagtcactca aaaagtcttg cagaagttag atgtgttttg a 951

<210> 2738 <211> 316 <212> PRT <213> Felis catus

<400> 2738 His Thr Arg Val Thr Glu Phe Leu Leu Leu Gly Met Ile 1 Cys Glu Asn 5 10 15 Phe Thr Asn Asn Pro Glu Met Gln Val Ser Leu Phe Ile Leu Phe Leu 20 25 30 Val Ile Tyr Thr Val Thr Leu Leu Gly Asn Phe Leu Ile Val Thr Val 35 40 45 Thr Ser Val Asp Pro Ala Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Leu Leu Glu Val Cys Phe Thr Leu Val Met Val Pro Lys 65 70 75 80 Met Leu Val Asp Leu Val Ser Pro Arg Lys Val Ile Ser Phe Val Gly 85 90 95 Cys Gly Ala Gln Met Tyr Phe Phe Phe Phe Phe Gly Ser Ser Glu Cys 100 105 110

Page 3047

Phe Leu Leu 115 Ser Met Met Ala 069269_0225_SL.TXT Tyr Asp Arg Phe Val Ala 120 125 Ile Cys Asn Pro Leu Arg Tyr Ser Val Ile Met Asn Arg Ser Leu Cys Leu Trp Met 130 135 140 Ala Val Gly Ser Trp Met Ser Gly Val Pro Val Ser Met Leu Gln Thr 145 150 155 160 Ala Trp Leu Met Ala Leu Pro Phe Cys Gly Pro Asn Thr Ile Asp His 165 170 175 Phe Phe Cys Asp Gly Pro Pro Val Leu Lys Leu Val Thr Gln Asp Thr 180 185 190 Ser Met Tyr Glu Met Gln Ala Leu Ala Ser Thr Leu Leu Phe Ile Met 195 200 205 Phe Pro Phe Ser Leu Ile Leu Val Ser Tyr Ile Arg Ile Ile Thr Thr 210 215 220 Val Leu Arg Met Pro Ser Ala Thr Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ile Val Val Ser Leu Phe Tyr Gly Thr Ala Ser 245 250 255 Leu Thr Tyr Leu Arg Pro Lys Ser Ser Gln Ser Pro Glu Ser Lys Lys 260 265 270 Leu Val Ser Leu Ser Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Asn Glu Val Lys Gly Ala Val Lys Arg Thr 290 295 300 Val Thr Gln Lys Val Leu Gln Lys Leu Asp Val Phe 305 310 315

Page 3048

069269_0225_SL.TXT <210> 2739 <211> 937 <212> DNA <213> Felis catus <400> 2739

tgatgggcaa ccagacatca gtgatagagt tcattcttct tggactgaca gctgacactg 60 agcttcaggc tgtgcttttc ctttttctgc tgctaactta cgtcttaagc atcgtgggaa 120 acttgaccat catcattctg accacgctgg attaccgcct ccagactcct atgtatttct 180 tcctccggaa tttttccatt ctggaaatat cttttacctc tgtctttgtt cccaaaatgc 240 tagtcaacat tggaactgga gacaggacta tctcctttgc tgcttgtttc actcagtatt 300 tttttgccat ccttctggga gcaaccgagt tttatctttt agctgccatg tcctttgacc 360 gctacgttgc catttgcaaa cccctacact atacaactgt aatgagcagg agactctgca 420 ttcaacttgt cttgtgttcc tggttctctg gttttttggt tgtcattggg cctcatataa 480 tgactctcca gctgcctttc tgtgcctcca acatcatcaa tcattactgc tgtgactgta 540 ctgtactgtt gcatctagct tgttcagaca cacatttcat agaagtgatg gagttcatct 600 tggctgcagt caccctcatc ttcaccttgg tgctagtgat cctttcctac acgtacatta 660 tcaggacaat tctgagaatc ccctctgttc aacagagaaa aaagcttttt ctacatgttt 720 ctctcatatg attgtggtct cactttctta tggaagttgt atctttatgt acataaatcc 780 ttctgttaag gatgcagaaa cttttaataa gggcgtggct gttttaaata catcagttgc 840 ccctctgttg aaccctttca tctataccct caggaataat caagtgaaaa tagccttcaa 900 agatatggtc agcaaagtaa cagctttttc aagaaaa 937

<210> 2740 <211> 242 <212> PRT <213> Felis catus <400> 2740

Met Gly Asn Gln Thr Ser Val Ile Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15

Ala Asp Thr Glu Leu Gln Ala Val Leu Phe Leu Phe Leu Leu Leu Thr 20 25 30

Page 3049

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Tyr Val Leu 35 Ser Ile Val Gly Asn Leu Thr Ile Ile Ile Leu Thr Thr 40 45 Leu Asp Tyr Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Ile Leu Glu Ile Ser Phe Thr Ser Val Phe Val Pro Lys Met Leu 65 70 75 80 Val Asn Ile Gly Thr Gly Asp Arg Thr Ile Ser Phe Ala Ala Cys Phe 85 90 95 Thr Gln Tyr Phe Phe Ala Ile Leu Leu Gly Ala Thr Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Val Met Ser Arg Arg Leu Cys Ile Gln Leu Val Leu 130 135 140 Cys Ser Trp Phe Ser Gly Phe Leu Val Val Ile Gly Pro His Ile Met 145 150 155 160 Thr Leu Gln Leu Pro Phe Cys Ala Ser Asn Ile Ile Asn His Tyr Cys 165 170 175 Cys Asp Cys Thr Val Leu Leu His Leu Ala Cys Ser Asp Thr His Phe 180 185 190 Ile Glu Val Met Glu Phe Ile Leu Ala Ala Val Thr Leu Ile Phe Thr 195 200 205 Leu Val Leu Val Ile Leu Ser Tyr Thr Tyr Ile Ile Arg Thr Ile Leu 210 215 220 Arg Ile Pro Ser Val Gln Gln Arg Lys Lys Leu Phe Leu His Val Ser 225 230 235 240

Page 3050

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Leu Ile <210> 2741 <211> 936 <212> DNA <213> Felis catus <400> 2741

ctacttggat aaagacagga ctctttgtag caagttctta aatgcttgct tcacctgttg 60 gttccttaga gtgcaaataa aagggttcaa aagtggtgtg actgaggtat tgagagttgc 120 tactcccttc attaaggata tcctctgttt gaccgagggt ttaatgtaca tgaagatgca 180 gctgccatat gagagcgaga tgacaatcat gtgagaagaa caagtggaga aagccttttt 240 tctctggttg gcagaaggga tttttaaaat tgtcaggcaa tatatgtgta cggtagaatc 300 agtaatgcca aggtgaccag cagagtcacc aaagctaaga tgaaactcat aatttccaac 360 acatgtgtat ctgtgcagga gatctgcagg aggggagcag tgtcacagta gaaatgatca 420 atggtactgg agtcacagaa gtccaggctt ctgtggacta aaatgagtcc tggaaagatt 480 atgagggaac cagtgatcca agagcttagg atcagctgga tacagatttt gctgctcatg 540 atggttgtat aatgcagggg cttaaagatg gcaacataac gatcatagga catgacaact 600 aggagataaa attcggatgc tccaagaagg aaggcaaaaa ataactgagc tgcacaacgg 660 ttataggaaa tggttttgtc cccagttgcc atgcttacaa gcaatttgta aatacacagt 720 tatataagaa atttctaaga aggaaaagtt ttgaagaaag aaatacatag gggtcttgag 780 atgagaaccc agcaaagtaa gggtaatgat aattaagttg tctgagatgc ttagcaagta 840 ggtgagaagc aggaagacga atagcacaat cttcaccttt gggtcctctg tcaatcctgc 900 taagataaat actgtcacag ttgtacggtt ttccat 936

<210> 2742 <211> 91 <212> PRT <213> Felis catus <400> 2742

Met Glu Asn Arg Thr Thr Val Thr Val Phe Ile Leu Ala Gly Leu Thr 1 5 10 15

Page 3051

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Glu Asp Pro Lys Val Lys Ile Val Leu Phe Val Phe Leu Leu Leu Thr 20 25 30 Tyr Leu Leu Ser Ile Ser Asp Asn Leu Ile Ile Ile Thr Leu Thr Leu 35 40 45 Leu Gly Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Gln Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Tyr Ile Thr Val Tyr Leu Gln Ile Ala Cys 65 70 75 80 Lys His Gly Asn Trp Gly Gln Asn His Phe Leu 85 90

<210> 2743 <211> 938 <212> DNA <213> Felis catus <400> 2743 atgagaaacc acaccacggt aacaaccttc attcttcttg gactgaccga taacccacaa ttacaagtgg ttatttttct tctccttttt tcacctatat gttgagtgtc actgggaatc taaccataat caccctcacc ctgttggatt ctcatctaaa gatacccatg tacttcttcc tccgaagctt ttcattttta gaaatcttat tcacaactgt ctgcatcccc aaatttcttg tcagcatggc aacaggtgac aagaccattt cttacaacag ttgtgcaaca cagctgtttt ttactactgt cttgggtgca atcgaatttt ttcttctggt tgccatgtct tatgaccgct atgtagccat ctgcaaaccc ttgcattaca ccaccatcat gagtgacaga gtctgcaact tgttggtctt tgcttcatgg ttggccggtt ttatagtaat tgtcccacca ctccttgtgg gtctccagct agacttctgt gcagccaaca ctgtaaatca tttcttctgt gattttactc ctatattaca gctctcttgc acagacacag ctgtaataga attaatggca tttctctcag ccattttgac actcctggtt acactggtat tagtgattct ctcctatgca aacatcatca ggactattct gaagatacct tcttctcaac agaggaagaa agccttttct acatgttctt

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Page 3052

069269_0225_SL.TXT ctcacatggt ggttgtgtcc atttcttatg gcagctgcat cttcatgtat gtgaagcctt ctacaaagga gagagtgtct ttaaataaag ggatagcctt gctcagtact tctgttgccc ccatgttgaa tcccttcatt tatacactga gaaacaaaca agtgcaagat gcttttaggc acatgctcaa aaagattaag attttctcaa gtaagtga

780

840

900

938 <210> 2744 <211> 279 <212> PRT <213> Felis catus <400> 2744

Met 1 Leu Ser Val Thr 5 Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu Leu 10 15 Asp Ser His Leu Lys Ile Pro Met Tyr Phe Phe Leu Arg Ser Phe Ser 20 25 30 Phe Leu Glu Ile Leu Phe Thr Thr Val Cys Ile Pro Lys Phe Leu Val 35 40 45 Ser Met Ala Thr Gly Asp Lys Thr Ile Ser Tyr Asn Ser Cys Ala Thr 50 55 60 Gln Leu Phe Phe Thr Thr Val Leu Gly Ala Ile Glu Phe Phe Leu Leu 65 70 75 80 Val Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His 85 90 95 Tyr Thr Thr Ile Met Ser Asp Arg Val Cys Asn Leu Leu Val Phe Ala 100 105 110 Ser Trp Leu Ala Gly Phe Ile Val Ile Val Pro Pro Leu Leu Val Gly 115 120 125 Leu Gln Leu Asp Phe Cys Ala Ala Asn Thr Val Asn His Phe Phe Cys 130 135 140 Asp Phe Thr Pro Ile Leu Gln Leu Ser Cys Thr Asp Thr Ala Val Ile Page 3053

069269_0225_SL.TXT

145 150 155 160 Glu Leu Met Ala Phe Leu Ser Ala Ile Leu Thr Leu Leu Val Thr Leu 165 170 175 Val Leu Val Ile Leu Ser Tyr Ala Asn Ile Ile Arg Thr Ile Leu Lys 180 185 190 Ile Pro Ser Ser Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser 195 200 205 His Met Val Val Val Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met Tyr 210 215 220 Val Lys Pro Ser Thr Lys Glu Arg Val Ser Leu Asn Lys Gly Ile Ala 225 230 235 240 Leu Leu Ser Thr Ser Val Ala Pro Met Leu Asn Pro Phe Ile Tyr Thr 245 250 255 Leu Arg Asn Lys Gln Val Gln Asp Ala Phe Arg His Met Leu Lys Lys 260 265 270 Ile Lys Ile Phe Ser Ser Lys

275 <210> 2745 <211> 939 <212> DNA <213> Felis catus <400> 2745

atgggaaatc acacacaagt gacagtgttt atcctggcag gtttgactga tgatccacaa 60 ttgaaagttg tgctatttgt cttcctgctt ctcacctacc tgctaagtgt cactggcaat 120 ctgctcatca tcacactcac cctggtggat atcaccctca agacccccat gtattttttc 180 cttcggaatt tttccttcct agaaatttcc tatactacca catgcattcc caaattgttg 240 gttgctatgg caactggaaa caaaaccatt tcctttaatt gttgtgttac tcaagtgttt 300 tttgccttcc ttcttggtgc atctgaattt tacttgctgg cagccatgtc ctatgaccgc 360

Page 3054

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tatgttgcca tctgtaagcc cctgcactac acaaccatca tgagcagtaa gatctgcatg 420 caacttgtct tctgttgttg gcttgctggg ttttttgtca tctttccacc tctcctctta 480 ggcataaacc ttgacttctg tgcctccaac gttgttgatc atttctactg tgatacaact 540 cccctgctgc agatctcctg ctcagacaca cagctcttag agaccatggg attcatttct 600 gcatcagtga cacttgtggt cacgttggta atggtgataa tatcatacag ctttattgca 660 ttaacaattc taaacatccc ttcaactaat caaaagaaaa aggctttttc aacatgttcc 720 tctcacatga ttgtgatatc tctttcttac ggcagctgta tcttcatgta cgttaagccg 780 tcagtcaaac aaagaatatc tttttccaag ggaattgcag tgctcaatac ctccattgcc 840 ccacttttaa atcctttcat ttacacttta cggaaccagc aagtgaaaaa agccttcatg 900 aacatgatac aaagggttgt ttctttctca agcaaatga 939

<210> 2746 <211> 312 <212> PRT <213> Felis catus <400> 2746

Met Gly Asn His Thr Gln Val Thr Val Phe Ile Leu Ala Gly Leu Thr 1 5 10 15 Asp Asp Pro Gln Leu Lys Val Val Leu Phe Val Phe Leu Leu Leu Thr 20 25 30 Tyr Leu Leu Ser Val Thr Gly Asn Leu Leu Ile Ile Thr Leu Thr Leu 35 40 45 Val Asp Ile Thr Leu Lys Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Tyr Thr Thr Thr Cys Ile Pro Lys Leu Leu 65 70 75 80 Val Ala Met Ala Thr Gly Asn Lys Thr Ile Ser Phe Asn Cys Cys Val 85 90 95

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Thr Gln Val Phe 100 Phe Ala Phe Leu Leu Gly Ala Ser Glu Phe Tyr Leu 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Ser Ser Lys Ile Cys Met Gln Leu Val Phe 130 135 140 Cys Cys Trp Leu Ala Gly Phe Phe Val Ile Phe Pro Pro Leu Leu Leu 145 150 155 160 Gly Ile Asn Leu Asp Phe Cys Ala Ser Asn Val Val Asp His Phe Tyr 165 170 175 Cys Asp Thr Thr Pro Leu Leu Gln Ile Ser Cys Ser Asp Thr Gln Leu 180 185 190 Leu Glu Thr Met Gly Phe Ile Ser Ala Ser Val Thr Leu Val Val Thr 195 200 205 Leu Val Met Val Ile Ile Ser Tyr Ser Phe Ile Ala Leu Thr Ile Leu 210 215 220 Asn Ile Pro Ser Thr Asn Gln Lys Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Ile Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Val Lys Pro Ser Val Lys Gln Arg Ile Ser Phe Ser Lys Gly Ile 260 265 270 Ala Val Leu Asn Thr Ser Ile Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Gln Gln Val Lys Lys Ala Phe Met Asn Met Ile Gln 290 295 300

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Arg Val Val Ser Phe Ser Ser Lys

305 310 <210> 2747 <211> 940 <212> DNA <213> Felis catus <400> 2747 ttacaattgt ttttatgaaa agcacatctt ttgtaacata tcccagaaga cttcttttac 60 ctgctgtttc cttagggtat aaataaaggg atttagtaaa ggggcaactg aggtatacag 120 caaagctaca gctttggata aagtcactct ttctttggca aatggtttaa tatacataaa 180 gatgcaactc ccataagtca tggagacaac aatcatatgg gaagtatagg tggaaaaagc 240 tttggtcctt tgctgtgctg aagggaattt aataatggtc ttaataatgc aagtgtaaga 300 cagaatcacc aacaccaatg tgatcataag tgtcacaaca gcaaagataa aagacaccaa 360 ttctaggaca tgtgtatctg tgcaggatat ctgcaggata ggaggagttt cacacataaa 420 gtgatcaatt attttggaag cacaaaaatc cagcttgagt cccatgacca ttggtggaaa 480 gatgattagg aatccagtta cccaagagga gagtacaagt tgatagcaca ctttgctgtt 540 cataatgatt gggtaatgca agggattaca gatggcaaca tagcggtcat aggacatagc 600 agccaaggta aaactccata acccccagta aaagaataaa aaataattga gctgcacaat 660 tgttatatga gatggttttt tctctagcca caatggttat caagtatctg ggaatacata 720 ctgttgtgaa tatgatttcc aaaaatgaga aattatggag aaaaaaatgc attggtggct 780 tgaggcgagg atctagcagg gtaaggagga taatgattaa gttccccaac aagctcaata 840 tgtaattaag aaatagaaac atgaaaacca caatttgcaa ttgtgggtca tctgtcaatc 900 cttggagaat gaaatctatt tccatcgatt gttttttcat 940 <210> 2748 <211> 117 <212> PRT <213> Felis catus <400> 2748

Met Lys Lys Gln Ser Met Glu Ile Asp Phe Ile Leu Gln Gly Leu Thr 1 5 10 15

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Asp Asp Pro Gln Leu Gln Ile Val Val Phe Met Phe Leu Phe Leu Asn 20 25 30 Tyr Ile Leu Ser Leu Leu Gly Asn Leu Ile Ile Ile Leu Leu Thr Leu 35 40 45 Leu Asp Pro Arg Leu Lys Pro Pro Met His Phe Phe Leu His Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ile Phe Thr Thr Val Cys Ile Pro Arg Tyr Leu 65 70 75 80 Ile Thr Ile Val Ala Arg Glu Lys Thr Ile Ser Tyr Asn Asn Cys Ala 85 90 95 Ala Gln Leu Phe Phe Ile Leu Leu Leu Gly Val Met Glu Phe Tyr Leu 100 105 110 Gly Cys Tyr Val Leu

115

<210> 2749 <211> 938 <212> DNA <213> Felis catus <400> 2749 atgaggaatc agtcaagaga gatggagttc attctcctag gactgaccga tgacccacaa 60 ctgcaaattg tgatttttgt atttctcttt ctaaattatg tgttgagtgt aatggggaac 120 ttatccatca tccttcttac cttgctagat ccccgcctca agactcccat gtatttttcc 180 tccgaaattt ctccttcttg gaagcttcat tgacaacagt ctgtattccc agattcctga 240 taagcattgt gactaaaaac aaaacaatat cctatgatag ttgtgcatct cagttattct 300 ttttcctctt attagaaatt acagaatttt acctactggc tgccatgtct tttgaccgtt 360 atgtagcaat ctgcaaaccc ctacattatc cagtgattat gaacaacaaa gtgtgttacc 420 aacttctatt cagttcatgg acatcaggct ttctatttac atttccacca ttggccttgg 480 gactgacact ggaattctgt gcttccagag taattgatca tttcatgtgt gacatttccc 540

Page 3058

069269_0225_SL.TXT

ctgtgctgca gctttcttgc actgacactc atttcctgga attattttca tttgtcttag 600 ctattttaac actcctagtc acattgctgt tagtgactct ttcttacaca tatattatca 660 agaccattct aaaaatcccc tctgctcaga aaagaacaaa ggctttttct acttgttctt 720 ctcatataat tgtggtctcc cttacttatg gtagctgtat ctttaattac ataaaaccaa 780 cagcaaagga aagggtaact ttatccaaag gtgtaactgt tatctatacc tcagttgccc 840 ctttattaaa ccctttcatt tacactctaa gaaaccagca agtgaaacaa gccttcaaag 900 atatactcca aaagactttc tcttttttca aaaaatga 938

<210> 2750 <211> 197 <212> PRT <213> Felis catus

<400> 2750 Tyr Val Ala Ile Cys 10 Lys Pro Leu His Tyr 15 Pro Met 1 Ser Phe Asp Arg 5 Val Ile Met Asn Asn Lys Val Cys Tyr Gln Leu Leu Phe Ser Ser Trp 20 25 30 Thr Ser Gly Phe Leu Phe Thr Phe Pro Pro Leu Ala Leu Gly Leu Thr 35 40 45 Leu Glu Phe Cys Ala Ser Arg Val Ile Asp His Phe Met Cys Asp Ile 50 55 60 Ser Pro Val Leu Gln Leu Ser Cys Thr Asp Thr His Phe Leu Glu Leu 65 70 75 80 Phe Ser Phe Val Leu Ala Ile Leu Thr Leu Leu Val Thr Leu Leu Leu 85 90 95 Val Thr Leu Ser Tyr Thr Tyr Ile Ile Lys Thr Ile Leu Lys Ile Pro 100 105 110 Ser Ala Gln Lys Arg Thr Lys Ala Phe Ser Thr Cys Ser Ser His Ile 115 120 125

Page 3059

069269_0225_SL.TXT

Ile Val Val Ser Leu Thr Tyr Gly Ser Cys Ile Phe Asn Tyr Ile Lys 130 135 140

Pro Thr Ala Lys Glu Arg Val Thr Leu Ser Lys Gly Val Thr Val Ile 145 150 155 160

Tyr Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr Thr Leu Arg 165 170 175

Asn Gln Gln Val Lys Gln Ala Phe Lys Asp Ile Leu Gln Lys Thr Phe 180 185 190

Ser Phe Phe Lys Lys 195 <210> 2751 <211> 928 <212> DNA <213> Felis catus <400> 2751 atgagaaacc acacagaaat aacagagttt cttcaggtgg tgatctttgt ctctctgctc ctgaccatta tcacccttac cctgctggat ctcagaaact tctccttatt agaggtttca ggcaccatga tgactggaga taaaaccatt ttttcattct cttgggagtc actgaatttt acattgccat ctgcaaacct ctgcattaca tccttgtctt ctcttcgtgg ctaacgtcat tcctaaacct taattactgt aggtctaatg ccctgctgca actttcctgt tcagacacaa ctgtgttcac tttaatgttc actttggcct gaacaatttt aagaattcct tctactagtc atcctcctgg atcacctaca tcccacctcc ttcacaactg tcctttaatg accttctggc tgaccatcat tcttaatcat ttattgacca aattcttaga tgatatttct agaggaaaaa

gattgtcaga tgacccacag 60 tgctcagcat cactggcaac 120 agacccccat gtatttcttc 180 tcagcatacc caagttcctg 240 actgcattgc tcagctattt 300 cgccatgtcc tatgaccgtt 360 gaatcacaga gtctgcatac 420 attccccgca ctcatgttgc 480 ttttacctgt gattattttc 540 ggcgctgggg ttttcctgcg 600 gtcttacaca tatatcatca 660 ggccttttcc acatgttcat 720

Page 3060

069269_0225_SL.TXT cccatatgat tgtcatctcc atctcctatg gcagctgcat tttcatgtac attaatccat cagcaaaaga cacagtgtct ctgagcaagg gagttgctgt gctaaacacc tcagtggccc ccatgctgaa cccctttatt tacagcctaa ggaatcagca agtcaggcga gccttcatgg acagggcaag gaagattgta tttttctc

780

840

900

928 <210> 2752 <211> 195 <212> PRT <213> Felis catus

<400> 2752 Met Ser 1 Tyr Asp Arg 5 Tyr Ile Ala Thr Ile Met Asn 20 His Arg Val Cys Leu Thr Ser 35 Phe Leu Ile Ile Phe 40 Leu Asn 50 Tyr Cys Arg Ser Asn 55 Val Phe 65 Pro Leu Leu Gln Leu 70 Ser Cys Leu Gly Phe Ser Cys 85 Ala Val Phe Ile Phe Leu Ser 100 Tyr Thr Tyr Ile Ser Thr Ser 115 Gln Arg Lys Lys Ala 120 Ile Val 130 Ile Ser Ile Ser Tyr 135 Gly Pro Ser Ala Lys Asp Thr Val Ser

Ile Cys 10 Lys Pro Leu His Tyr 15 Met Ile 25 Leu Leu Val Phe Ser 30 Ser Trp Pro Ala Leu Met Leu 45 Leu Leu Asn Ile Asp His Phe 60 Thr Cys Asp Tyr Ser Asp Thr 75 Lys Phe Leu Glu Ala 80 Thr Leu 90 Met Phe Thr Leu Ala 95 Leu Ile 105 Arg Thr Ile Leu Arg 110 Ile Pro Phe Ser Thr Cys Ser 125 Ser His Met Ser Cys Ile Phe 140 Met Tyr Ile Asn Leu Ser Lys Gly Val Ala Val Leu

Page 3061

06926 9_02 25_S L.TX T 145 150 155 160 Asn Thr Ser Val Ala Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg 165 170 175 Asn Gln Gln Val Arg Arg Ala Phe Met Asp Arg Ala Arg Lys Ile Val 180 185 190

Phe Phe Ser 195 <210> 2753 <211> 931 <212> DNA <213> Felis catus <400> 2753

atgagaaacc acacagaaat aacagagttt atcctcctgg gattgtcaga tgacccacag 60 cttcaggtgg tgatctttgt ctctctgctc atcacctaca tgctcagcat cactggcaac 120 ctgaccatta tcacccttac cctgctggat tcccacctcc agacccccat gtacttcttc 180 ctcagaaact tctccttatt agaggtttca ttcacaactg tcagcatacc caagttcctg 240 ggcaccatga tgactggaga taaaaccatt tcctttaatg attgtatgat tcagttattt 300 tttttcattc tcttgggagt cactgaattt taccttttgg ccgccatgtc ctatgaccgt 360 tacattgcca tctgcaaacc tctgcattac atgaccatca tgaatcacag agtctgcata 420 ctccttgtct ttgcttcatg gctggcttca ttcttaatca tattcccatc acttatgctg 480 ttcatacaac ttgattactg taagtccaat gttatagacc attttacctg tgattatttt 540 cccttactac acctttcttg ttcagacaca aaattcctag agatagtggg tttttcctgc 600 gctgtgttta ctctaatgtt cactttggcg ttaatagttc tgtcctacat atatatcatc 660 agaacaattt tgaggattcc ttctgctagt cagaggacaa aggccttttc cacctgttct 720 tcccacatga tcgtcatctc catctcctat ggcagctgca ttttcatgta cattaatcca 780 tcagcaaaag acagagtgtc tctgagcaag ggagttgctg tgctaaacac ctcagtggcc 840 cccatgctga acccctttat ttacagccta aggaatcaac aagtcaagca agccttcatg 900 gacagggcaa aaaagattgt atctttctca a 931

Page 3062

069269_0225_SL.TXT <210> 2754 <211> 311 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (311)..(311) <223> Any amino acid

<400> 2754 Glu Ile Thr Glu Phe Ile Leu Leu Gly Leu Ser Met Arg 1 Asn His Thr 5 10 15 Asp Asp Pro Gln Leu Gln Val Val Ile Phe Val Ser Leu Leu Ile Thr 20 25 30 Tyr Met Leu Ser Ile Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Leu Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Leu Leu Glu Val Ser Phe Thr Thr Val Ser Ile Pro Lys Phe Leu 65 70 75 80 Gly Thr Met Met Thr Gly Asp Lys Thr Ile Ser Phe Asn Asp Cys Met 85 90 95 Ile Gln Leu Phe Phe Phe Ile Leu Leu Gly Val Thr Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Ile Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn His Arg Val Cys Ile Leu Leu Val Phe 130 135 140 Ala Ser Trp Leu Ala Ser Phe Leu Ile Ile Phe Pro Ser Leu Met Leu 145 150 155 160

Page 3063

069269_0225_SL.TXT

Phe Ile Gln Leu Asp Tyr 165 Cys Lys Ser Asn Val Ile Asp His Phe Thr 170 175 Cys Asp Tyr Phe Pro Leu Leu His Leu Ser Cys Ser Asp Thr Lys Phe 180 185 190 Leu Glu Ile Val Gly Phe Ser Cys Ala Val Phe Thr Leu Met Phe Thr 195 200 205 Leu Ala Leu Ile Val Leu Ser Tyr Ile Tyr Ile Ile Arg Thr Ile Leu 210 215 220 Arg Ile Pro Ser Ala Ser Gln Arg Thr Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Ile Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Asn Pro Ser Ala Lys Asp Arg Val Ser Leu Ser Lys Gly Val 260 265 270 Ala Val Leu Asn Thr Ser Val Ala Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Met Asp Arg Ala Lys 290 295 300 Lys Ile Val Ser Phe Ser Xaa

305 310 <210> 2755 <211> 938 <212> DNA <213> Felis catus <400> 2755 atgaaaaatc acacagtacc caaagaattc attcttctag ggatatctga tgacccagag ctccagactg tgatttttct ctttttaatt accacatata tattaagtgt cactggaaat

120

Page 3064

069269_0225_SL.TXT

ctgaccatca tcactctcac cttggtggat tcccatctac agacccctat gtatttcttc 180 ctcaggaact tctctgtatt agaaatatcc tttacaactg tctgtattcc taggtttctg 240 ggcacaatta tcaccagaga caaatctatt tcatacaata attgtacagc tcagttgttt 300 ttcttcatct tcatgggtat aactgagttt tatcttctca ctgccatgtc ctatgatcgc 360 tatgtagcca tctgtaaacc cctacattat gcaaccatca tgaacaaaag agtctgcatt 420 ttacttgtct tttgtgcttg gctggcagga ttcttaaata tcttcccacc agttattctt 480 tttctccagt tagattactg tggctccaat gtcatcgatc actttgtttg tgactatttt 540 cccctcttgc agttatcttg ctcagacaca tggctcctag aagtgattgg cttttactct 600 gcaatagtca tactgctttt cactttggca ttaataattc tatcctacat gttcatcatg 660 agaacaattc tgaaactgcc ttccgccagt cagagaaaaa aggcattttc tacgtgttcc 720 tctcacatga ttgtcatttc catctcttat ggaagctgca tattcatgta tgccaaccct 780 tctgcaaaca gaaggcatca ttgaccaaag gagtagctat tctgaatacc tctgtggctc 840 ctatgatgaa tccatttata tataccctga ggaaccagca agtaaagcaa gcctttaagg 900 atactgtcca aaaggttttg tttttctcca gtaattga 938

<210> 2756 <211> 267 <212> PRT <213> Felis catus <400> 2756

Met 1 Lys Asn His Thr Val 5 Pro Lys Glu Phe Ile Leu Leu Gly Ile Ser 10 15 Asp Asp Pro Glu Leu Gln Thr Val Ile Phe Leu Phe Leu Ile Thr Thr 20 25 30 Tyr Ile Leu Ser Val Thr Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Val Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Val Leu Glu Ile Ser Phe Thr Thr Val Cys Ile Pro Arg Phe Leu Page 3065

069269_0225_SL.TXT

Gly Thr Ile Ile Thr Arg Asp Lys Ser Ile Ser Tyr Asn Asn Cys Thr 85 90 95 Ala Gln Leu Phe Phe Phe Ile Phe Met Gly Ile Thr Glu Phe Tyr Leu 100 105 110 Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Ala Thr Ile Met Asn Lys Arg Val Cys Ile Leu Leu Val Phe 130 135 140 Cys Ala Trp Leu Ala Gly Phe Leu Asn Ile Phe Pro Pro Val Ile Leu 145 150 155 160 Phe Leu Gln Leu Asp Tyr Cys Gly Ser Asn Val Ile Asp His Phe Val 165 170 175 Cys Asp Tyr Phe Pro Leu Leu Gln Leu Ser Cys Ser Asp Thr Trp Leu 180 185 190 Leu Glu Val Ile Gly Phe Tyr Ser Ala Ile Val Ile Leu Leu Phe Thr 195 200 205 Leu Ala Leu Ile Ile Leu Ser Tyr Met Phe Ile Met Arg Thr Ile Leu 210 215 220 Lys Leu Pro Ser Ala Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Ile Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ala Asn Pro Ser Ala Asn Arg Arg His His 260 265

<210> 2757

Page 3066

069269_0225_SL.TXT <211> 939 <212> DNA <213> Felis catus <400> 2757

atgaaaaatt acacctcagt aacagaattt attcttcttg gattgacaaa tgacccacag 60 tggcaggttg tacttttcgt atttcttctt gctacctaca tgctaagtgt gactgggaac 120 ctgatcattg tcaccctcac cctttcagat gcccacctgc agacgccaat gtatttcttc 180 cttcgaaact tctcattcct agaaatatca ttcacgtctg tctgcattcc cagattcctt 240 gtcacttttg tgacaaggga cagaaccatt tcctacaatg gttgtgtgac tcagctattt 300 ttcttcatct tcttgggggt gacagaattt taccttctgg ctgccatgtc ctatgaccgc 360 tacgtggcca tctgcaagcc tctccattac atgaccatca tgagcaacag agtctgcacc 420 cttcttgtct ttagctcgtg gcttgcagga ttcctgatca tctttccacc aatactgttg 480 cttctacagt tggatttctg tgcctccaat gtaattgatc attttatctg tgacgcttct 540 ccaattctac agctttcttg cacaaacact cgctttctag aactcatggc atttttttta 600 gcggtggtaa cacttatggt caccttaacg ctagttattc tgtcttacac atacatcatc 660 cgtacaattc tgagaattcc ttccacaagt caaaggaaga aagccttttc cacttgctcc 720 tcccacatga tagtggtctc cctctcttat ggaagctgca ttttcatgta cattaagcgt 780 tctgcaaggg aaagggtgac tttaagcaaa ggagtagctg tgctcaatac ctcagtggct 840 cctctcttaa atcctttcat atatacacta aggaatcagc aggtgaagca agcctttaag 900 aatgtggtcc agagaatggc cttttactca aataaatga 939

<210> 2758 <211> 312 <212> PRT <213> Felis catus <400> 2758

Met Lys Asn Tyr Thr Ser Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Asn Asp Pro Gln Trp Gln Val Val Leu Phe Val Phe Leu Leu Ala Thr

20 25 30

Page 3067

069269_0225_SL.TXT

Tyr Met Leu Ser Val 35 Thr Gly Asn Leu Ile Ile Val Thr Leu Thr Leu 40 45 Ser Asp Ala His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Phe Thr Ser Val Cys Ile Pro Arg Phe Leu 65 70 75 80 Val Thr Phe Val Thr Arg Asp Arg Thr Ile Ser Tyr Asn Gly Cys Val 85 90 95 Thr Gln Leu Phe Phe Phe Ile Phe Leu Gly Val Thr Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Ser Asn Arg Val Cys Thr Leu Leu Val Phe 130 135 140 Ser Ser Trp Leu Ala Gly Phe Leu Ile Ile Phe Pro Pro Ile Leu Leu 145 150 155 160 Leu Leu Gln Leu Asp Phe Cys Ala Ser Asn Val Ile Asp His Phe Ile 165 170 175 Cys Asp Ala Ser Pro Ile Leu Gln Leu Ser Cys Thr Asn Thr Arg Phe 180 185 190 Leu Glu Leu Met Ala Phe Phe Leu Ala Val Val Thr Leu Met Val Thr 195 200 205 Leu Thr Leu Val Ile Leu Ser Tyr Thr Tyr Ile Ile Arg Thr Ile Leu 210 215 220 Arg Ile Pro Ser Thr Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240

Page 3068

Ser His Met Ile Val 245 Val Ser 069269_0225_SL.TXT Leu Ser Tyr Gly Ser Cys 250 Ile Phe 255 Met Tyr Ile Lys Arg Ser Ala Arg Glu Arg Val Thr Leu Ser Lys Gly Val 260 265 270 Ala Val Leu Asn Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asn Val Val Gln 290 295 300 Arg Met Ala Phe Tyr Ser Asn Lys 305 310

<210> 2759 <211> 837 <212> DNA <213> Felis catus <400> 2759

ttcattcttc ttggattaac aaatgaccca aagctaaatg ttttgatttt tctatttcta 60 tttttcacat atatactgag tataactgga aacctgacaa ttatcaccct cactctgata 120 gatcctcacc ttaaaactcc gatgtatttc ttccttagga atttctcttt tctagaaatc 180 gcattcacaa cagtttgcat tcctagattt ctggccagca ttataacagg ggatatgact 240 atttcctata attcttgcat ggtccaggtg tttttcttta tactccttgg ctcgacagaa 300 ttttttcttc tgactgctat gtcttatgat cggtatatag ctatctgtaa gccattgcat 360 tacacaacaa taatgaacag cagaatttgc aaccagcttg taattagctc ttggctggct 420 ggatttctca ttatctttcc acctgtcatg atgggacttc aactggattt ctgtgactcc 480 aacatcattg accatttcac ctgtgactct tctcctatgc tgttgatctc ctgcacggac 540 acagcattcc tagagctcct gggattcttc ctagcagtat tcacactcat ggtgacctta 600 atattagtga ctctttccta tgtattcatc cttaaaacaa ttctgagaat cccctcgcct 660 gagcaaagga aaaaggcctt ttccacttgt tcctcacaca tgattgtagt ttccatttct 720 tatggaagtt gcattttcat gtacatcaaa acttcagcaa aagaaggagt ggctttgacc 780

Page 3069

837

069269_0225_SL.TXT aagggtatag cagtgctcaa tacttctgtt gccccaatgc taaatccttt tatttac <210> 2760 <211> 279 <212> PRT <213> Felis catus

<400> 2760 Phe Ile Leu Leu Gly Leu Thr Asn Asp Pro Lys Leu Asn Val Leu 15 Ile 1 5 10 Phe Leu Phe Leu Phe Phe Thr Tyr Ile Leu Ser Ile Thr Gly Asn Leu 20 25 30 Thr Ile Ile Thr Leu Thr Leu Ile Asp Pro His Leu Lys Thr Pro Met 35 40 45 Tyr Phe Phe Leu Arg Asn Phe Ser Phe Leu Glu Ile Ala Phe Thr Thr 50 55 60 Val Cys Ile Pro Arg Phe Leu Ala Ser Ile Ile Thr Gly Asp Met Thr 65 70 75 80 Ile Ser Tyr Asn Ser Cys Met Val Gln Val Phe Phe Phe Ile Leu Leu 85 90 95 Gly Ser Thr Glu Phe Phe Leu Leu Thr Ala Met Ser Tyr Asp Arg Tyr 100 105 110 Ile Ala Ile Cys Lys Pro Leu His Tyr Thr Thr Ile Met Asn Ser Arg 115 120 125 Ile Cys Asn Gln Leu Val Ile Ser Ser Trp Leu Ala Gly Phe Leu Ile 130 135 140 Ile Phe Pro Pro Val Met Met Gly Leu Gln Leu Asp Phe Cys Asp Ser 145 150 155 160 Asn Ile Ile Asp His Phe Thr Cys Asp Ser Ser Pro Met Leu Leu Ile 165 170 175

Page 3070

069269_0225_SL.TXT

Ser Cys Thr Asp Thr Ala Phe Leu Glu Leu Leu Gly Phe Phe Leu Ala 180 185 190 Val Phe Thr Leu Met Val Thr Leu Ile Leu Val Thr Leu Ser Tyr Val 195 200 205 Phe Ile Leu Lys Thr Ile Leu Arg Ile Pro Ser Pro Glu Gln Arg Lys 210 215 220 Lys Ala Phe Ser Thr Cys Ser Ser His Met Ile Val Val Ser Ile Ser 225 230 235 240 Tyr Gly Ser Cys Ile Phe Met Tyr Ile Lys Thr Ser Ala Lys Glu Gly 245 250 255 Val Ala Leu Thr Lys Gly Ile Ala Val Leu Asn Thr Ser Val Ala Pro 260 265 270 Met Leu Asn Pro Phe Ile Tyr

275

<210> 2761 <211> 892 <212> DNA <213> Felis catus <400> 2761 aaggtttgtt taacttactg gtttctcaga gtataaatga atggattcaa caaaggggca 60 actgaagtat tgagcacagc tactcctttg cttgaagtaa ctcatttgca gatggcttta 120 tgtacatgaa tatacaacta ccataactga tggatacaat aatcatgtga gaagaacagg 180 tagaaagggc ttttttcttt tgcttaattg aagggaattt tagaattttc ttgatgatat 240 aagagtaaga aaggattact aagaacaatg tgacagtaag gatcatcaca gctaagaaaa 300 aagcaatcag gtctaggaaa tgtgtgtctg agcaagaaag ttgcaggaca ggagaaatgt 360 cacaaatgaa atgatcaatg atgtttgagg cacagaaatc caggttaaga attaagatca 420 gtggagggaa aatcaccagg aattcagtta cccaagaact gagtacaagc taatgacaaa 480 ttctgctgtt catgatagat gtataatgca aaggtttaca gatggcaaca tagcggtcat 540

Page 3071

069269_0225_SL.TXT

aggacatagc tgccagaagg aaaaattcta taatccccaa taatatgcag aaaaataact 600 gagatataca atcattatag gaaatggtct tttctctggt tacaatggtg attaggaatc 660 tggggaaaca agcacttgtg aatgaaattt ccaggaaaga gaaattacat aggaagaaat 720 acattggggt cttgagatga gaatccagta gtgtgagggc aatgatggtt aagtttccta 780 tcatactcaa catgtaattt agaagtagaa ataaaaaaat tacaatcttt aactgagaat 840 aatctgtcag tcccagaagg ataaacttta tctgttttgt atggtgcttc at 892

<210> 2762 <211> 140 <212> PRT <213> Felis catus <400> 2762

Met 1 Lys His His Thr 5 Lys Gln Ile Lys Phe Ile Leu Leu Gly Leu Thr 10 15 Asp Tyr Ser Gln Leu Lys Ile Val Ile Phe Leu Phe Leu Leu Leu Asn 20 25 30 Tyr Met Leu Ser Met Ile Gly Asn Leu Thr Ile Ile Ala Leu Thr Leu 35 40 45 Leu Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Cys Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Phe Thr Ser Ala Cys Phe Pro Arg Phe Leu 65 70 75 80 Ile Thr Ile Val Thr Arg Glu Lys Thr Ile Ser Tyr Asn Asp Cys Ile 85 90 95 Ser Gln Leu Phe Phe Cys Ile Leu Leu Gly Ile Ile Glu Phe Phe Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125

Page 3072

069269_0225_SL.TXT

His Tyr Thr Ser Ile Met Asn Ser Arg Ile Cys His 130 135 140 <210> 2763 <211> 932 <212> DNA <213> Felis catus <400> 2763

atgagaaatc acacagcaat aacaacattc atcctgttgg gacttacaga ggacccacag 60 ctgcaagttc tcctttttat cttcttattt ctcacctatg tgctgagcat gactggaaat 120 ctgaccatta tcattcttac attcatggat tttcatctta aaacacctat gtatgttttt 180 cttcgaaatt tctccatttt agaaatctta ttcacaacgg tatgtattcc caggttcttg 240 tacagcttat caactggaga taaaacgatt acttataatg cttgtgttag tcaagtattt 300 tttattgggg ttttgggggc cacagaattt tttctcctgg cagccatgtc ctatgaccgc 360 tacgtggcca tctgcaaacc ccttcattac atgaccatca tgaacaacaa attatgtacc 420 atctttgtct tctgttgctg gatctctggg ttgatgatca tcgtcacacc actcagtatg 480 ggcctccagc tggaattctg tgactccaat gccattgacc attttggctg cgacccattt 540 cctcttttta agatttcatg ctcagatacg tggcttatag aacagacagt tataatctgt 600 gcagtattga tattcattat tacactgatt ggtgtcattc tttcctacat atatatcatc 660 aggacaattc taagattccc ttctgcttcc caaaggaaaa aagctttctc cacttgttca 720 tctcacatga ttgttatttc catcacatat ggcagctgta ttttcatcta tatcaagcct 780 tcagccaaag aacaggtggg catcaataaa ggggtatccg tgcttactac atctgttgct 840 cctttgttga acccgttcat ttatactttg aggaacaagc aagtgaaaca agctttcaat 900 gacacaataa aaaaaattgc atttacctta ca 932

<210> 2764 <211> 311 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (311)..(311)

Page 3073

069269_0225_SL.TXT <223> Any amino acid

<400> 2764 Thr Phe Ile Leu Leu Gly Leu Thr Met 1 Arg Asn His Thr 5 Ala Ile Thr 10 15 Glu Asp Pro Gln Leu Gln Val Leu Leu Phe Ile Phe Leu Phe Leu Thr 20 25 30 Tyr Val Leu Ser Met Thr Gly Asn Leu Thr Ile Ile Ile Leu Thr Phe 35 40 45 Met Asp Phe His Leu Lys Thr Pro Met Tyr Val Phe Leu Arg Asn Phe 50 55 60 Ser Ile Leu Glu Ile Leu Phe Thr Thr Val Cys Ile Pro Arg Phe Leu 65 70 75 80 Tyr Ser Leu Ser Thr Gly Asp Lys Thr Ile Thr Tyr Asn Ala Cys Val 85 90 95 Ser Gln Val Phe Phe Ile Gly Val Leu Gly Ala Thr Glu Phe Phe Leu 100 105 110 Leu Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Asn Lys Leu Cys Thr Ile Phe Val Phe 130 135 140 Cys Cys Trp Ile Ser Gly Leu Met Ile Ile Val Thr Pro Leu Ser Met 145 150 155 160 Gly Leu Gln Leu Glu Phe Cys Asp Ser Asn Ala Ile Asp His Phe Gly 165 170 175 Cys Asp Pro Phe Pro Leu Phe Lys Ile Ser Cys Ser Asp Thr Trp Leu 180 185 190 Ile Glu Gln Thr Val Ile Ile Cys Ala Val Leu Ile Phe Ile Ile Thr

Page 3074

195 069269_0225_SL.TXT 200 205 Leu Ile Gly Val Ile Leu Ser Tyr Ile Tyr Ile Ile Arg Thr Ile Leu 210 215 220 Arg Phe Pro Ser Ala Ser Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Ile Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile 245 250 255 Tyr Ile Lys Pro Ser Ala Lys Glu Gln Val Gly Ile Asn Lys Gly Val 260 265 270 Ser Val Leu Thr Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Lys Gln Ala Phe Asn Asp Thr Ile Lys 290 295 300 Lys Ile Ala Phe Thr Leu Xaa 305 310

<210> 2765 <211> 961 <212> DNA <213> Felis catus <400> 2765 atgagaaacc aaaccacgct tacgactttc atcttgctgg gactgacaga tgacactcga 60 ctgaaaattt tgctttttat ctttctattt ctttcctaca tattgagtgc atctggaaac 120 ctaaccatca tcaccctcac tctgattgat tctcacctta aaacaccgat gtatcttttc 180 ctccaaaatt tctccttctt agaaatttca ttcacaactg cttgtatccc caggttctta 240 tatagcatat catctggtga caagtccatt acctataatg cttgtgtcag tcaactgttg 300 tttacagacc tctttgcagt aacagagttt tttctcctgg ccaccatgtc ctatgatcgc 360 tatgtggcca tctgcaaacc actgcattac atgaccatta tgaacagcag agtctgcaag 420 aacttcatcc tcttctgttg ggtagcagca ctgatcatca ttctcccacc actcagtcta 480

Page 3075

069269_0225_SL.TXT

ggtttggacc tggaattctg tgattcaaac atcattgatc atttttgctg tgatccatct 540 cctatcctga agatctcttg ctcagataca tggttgatag agcagatggt tatagtatgt 600 gctgtgttta cattcatcat caccctcatg tgtgtagttc tttcctacat atatatcatc 660 aggagcattc taaagttttc ctctgcccaa caaagaaaaa aggccttttc cacttgttct 720 tcccacatga ttgttgtttc cattacttat ggtagctgca tcttcattta tgtcaaacct 780 tcagccaagg atgaggtggc tattaataaa gggatttcac tccttattac ttctatctca 840 ccaatgctga atccctttat ttacacactg agaaacaagc aagtgaagca agcttttcat 900 gactcaatta aaaaaattgc attcctctca aagatgtaaa ggagaaatga gtcaatgaat 960

c 961 <210> 2766 <211> 312 <212> PRT <213> Felis catus

<400> 2766 Thr Leu Thr Thr Phe Ile Leu Leu Gly Leu Thr Met Arg 1 Asn Gln Thr 5 10 15 Asp Asp Thr Arg Leu Lys Ile Leu Leu Phe Ile Phe Leu Phe Leu Ser 20 25 30 Tyr Ile Leu Ser Ala Ser Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Ile Asp Ser His Leu Lys Thr Pro Met Tyr Leu Phe Leu Gln Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Phe Thr Thr Ala Cys Ile Pro Arg Phe Leu 65 70 75 80 Tyr Ser Ile Ser Ser Gly Asp Lys Ser Ile Thr Tyr Asn Ala Cys Val 85 90 95 Ser Gln Leu Leu Phe Thr Asp Leu Phe Ala Val Thr Glu Phe Phe Leu 100 105 110

Page 3076

069269_0225_SL.TXT

Leu Ala Thr Met 115 Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 120 125 His Tyr Met Thr Ile Met Asn Ser Arg Val Cys Lys Asn Phe Ile Leu 130 135 140 Phe Cys Trp Val Ala Ala Leu Ile Ile Ile Leu Pro Pro Leu Ser Leu 145 150 155 160 Gly Leu Asp Leu Glu Phe Cys Asp Ser Asn Ile Ile Asp His Phe Cys 165 170 175 Cys Asp Pro Ser Pro Ile Leu Lys Ile Ser Cys Ser Asp Thr Trp Leu 180 185 190 Ile Glu Gln Met Val Ile Val Cys Ala Val Phe Thr Phe Ile Ile Thr 195 200 205 Leu Met Cys Val Val Leu Ser Tyr Ile Tyr Ile Ile Arg Ser Ile Leu 210 215 220 Lys Phe Ser Ser Ala Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile 245 250 255 Tyr Val Lys Pro Ser Ala Lys Asp Glu Val Ala Ile Asn Lys Gly Ile 260 265 270 Ser Leu Leu Ile Thr Ser Ile Ser Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Lys Gln Ala Phe His Asp Ser Ile Lys 290 295 300 Lys Ile Ala Phe Leu Ser Lys Met 305 310

Page 3077

069269_0225_SL.TXT <210> 2767 <211> 891 <212> DNA <213> Felis catus <400> 2767

tacagtaaca acattcattt tctgggacag atgaccctga gctgcaagtt ctgattttta 60 tctttctatt ttttacctac aagctgagtg taacgggacc atcatcacac tcacttttgt 120 ggatccctac cttaaaacac ccatgtactt tttttttttt tttttttaca aaatttctcc 180 ttcttggaga tctcattcac cactgcctgt atttccaggt acttgtataa catagcaaca 240 ggtgacaagg tcattaccta taatgctcat gtcatccaag tgttttttac tgacctcttt 300 gcagtaacag aatttttctt gctggccatc atgtcctatg accattatgt ggccatctgc 360 aaacccttgc attgggtaac catcatgagc agaggagtct gcagcagtct tattttttcc 420 tgcttgttgg ctggattgtt ggtcataacc tcccccactt agtctggggc tagatctgaa 480 attctgtgac tcaaatttta ttgatcattt tctctgtgat gcttctcccc tcctaaagat 540 agcatgttca gacacatggc tcatgaaaca aactgtttta atctgtgctg acccccattt 600 tgacctttat atatgtagtt ctatcttata ttatcaaaac aattttagga tttccatctg 660 ttcagcaaag aaaaaaggcc ttttacacct gttcttccca catgactgta gttttcatca 720 cctatggcat atgcatgttc atttatatga ctcctacagc aaaagagaaa gggactacta 780 ataaagcagt ttcactactc actttttctg tttcacctac attaaatcca tttatttata 840 cactgagaaa taagtaaaaa aaagcctcag tgactcaatc aaaagagttg c 891

<210> 2768 <211> 19 <212> PRT <213> Felis catus <400> 2768

Ala Thr Leu Leu Ile Glu Ser Leu Arg Leu Phe Phe Thr Tyr Phe Ser 1 5 10 15

Val Tyr Lys

Page 3078

069269_0225_SL.TXT <210> 2769 <211> 938 <212> DNA <213> Felis catus <400> 2769

atgagaaacc acacagtaac aacttttatc ctactgggac taactgatga tccacaactg 60 aagattatga ttttcatctt tctatttctc acctacatgt tgagtataac tgggaacctg 120 ataatcatct cccttacttt catagattct caccttaaaa atgctatgta ctttttccta 180 caaaatttct ccttcttaga aatctcattt acctctgctt gtattcccag atatttgtac 240 aacttatcaa caggagacaa gacaatcaca tatgacaact gtgtcactca aatgttttta 300 ctgatctttt tggtgtaaca gaattttttc tccttgccac catgtcctat gatcggtatg 360 tggccatctg caaacccctg cattatgtga ccatcatgaa caacagggtc tgtagaagac 420 tcatcgtttg gtgctggaca actggcttct tggtcataat cccaccgctc agcctgggcc 480 taaagctgga attctgtgac tctaatgtta ttgaccattt tttctgtgat gtatcccccc 540 ttctaaagat atcatgctca gaaacatggc tcatagagca gatggtcata gtctgtgctg 600 tgttgacctt tattatgacc cttatatgtg tagttctatc ttacatatac atcatcaagg 660 ccattctaca attctcttct gcccaccaaa gaaaaaaggc attttctaca tgttcttccc 720 acatgattgt ggtctccatc acctatggaa gttgcatttt catctatgtt aagccttcag 780 caaaggaatt agtggctagt aacaagggtg tggtagtcct cattacatcc attgctccta 840 tgctgaaccc cttcatttac accttgagaa acaagcaagt aaaacaagct ctcaaagact 900 caatcaagag aattgcatta ttctcaagaa gtaatgga 938

<210> 2770 <211> 199 <212> PRT <213> Felis catus

<400> 2770 Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Val 1 5 10 15

Thr Ile Met Asn Asn Arg Val Cys Arg Arg Leu Ile Val Trp Cys Trp 20 25 30

Page 3079

069269_0225_SL.TXT

Thr Thr Gly 35 Phe Leu Val Ile Ile Pro Pro Leu Ser Leu Gly Leu Lys 40 45 Leu Glu Phe Cys Asp Ser Asn Val Ile Asp His Phe Phe Cys Asp Val 50 55 60 Ser Pro Leu Leu Lys Ile Ser Cys Ser Glu Thr Trp Leu Ile Glu Gln 65 70 75 80 Met Val Ile Val Cys Ala Val Leu Thr Phe Ile Met Thr Leu Ile Cys 85 90 95 Val Val Leu Ser Tyr Ile Tyr Ile Ile Lys Ala Ile Leu Gln Phe Ser 100 105 110 Ser Ala His Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser Ser His Met 115 120 125 Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile Tyr Val Lys 130 135 140 Pro Ser Ala Lys Glu Leu Val Ala Ser Asn Lys Gly Val Val Val Leu 145 150 155 160 Ile Thr Ser Ile Ala Pro Met Leu Asn Pro Phe Ile Tyr Thr Leu Arg 165 170 175 Asn Lys Gln Val Lys Gln Ala Leu Lys Asp Ser Ile Lys Arg Ile Ala 180 185 190 Leu Phe Ser Arg Ser Asn Gly

195 <210> 2771 <211> 920 <212> DNA <213> Felis catus <400> 2771

Page 3080

069269_0225_SL.TXT

atgaaaaatc atacagtaac aatcttcatc ctattgggcc tgacagacga ccctcaactt 60 caaattccaa tttttatgtt tctatttctc acttacatat tgagtataac tgggaatctg 120 accatcatat ccctcacttt agtagactct caccttaaaa cacccatgta ctttttccta 180 cagaattttg ccttattaga aatttctttt acatctgctt gtatccctag atatttatac 240 aacatagcaa caggtgacag gtcaattaca tataatattt gtgttattca agtgtttttt 300 accgatgttt ttggagtaac agaatttttt ctcttggctg ccatgtctta tgaccgctat 360 gtggccatct gcaaacccct gcagtatgta accatcatga acaacagagt gtgcaagagg 420 ctcgtcctct gctgttggat ggctggcttg ttgatcatac tcccgccact tactttgttc 480 ctcaatttga aattctgtga ttcaaatgtc attgattatt ttttctgtga tgcatctcca 540 atcttgaaga tttcatgttc agacacatgg ctcatagagc agttggttat tgtctgtgct 600 gtgctgacct tcattctgac ccttgtgtgt gttcttcaat cttacatttc tatcatcaag 660 accattctac aattcccctc tacccaacaa aggaaaagag ccttttccac ctgttcttct 720 cacatgattg tggtttccat cacctatgga agttgtatct tcatctatgt caatccttca 780 gcaaaggaat cagtgacaat taataagggt gtgacagtgc taatgacgtc catagctccc 840 atgttgaacc cattcattta cactctgaga aacaagcaag tgagacaagc tttcagtgat 900 tctttcaaaa aaattgcatt 920

<210> 2772 <211> 307 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (307)..(307) <223> Any amino acid <400> 2772

Met Lys Asn His Thr Val Thr Ile Phe Ile Leu Leu Gly Leu Thr Asp 1 5 10 15 Asp Pro Gln Leu Gln Ile Pro Ile Phe Met Phe Leu Phe Leu Thr Tyr

20 25 30

Page 3081

069269_0225_SL.TXT

Ile Leu Ser 35 Ile Thr Gly Asn Leu Thr Ile Ile Ser Leu Thr Leu Val 40 45 Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Gln Asn Phe Ala 50 55 60 Leu Leu Glu Ile Ser Phe Thr Ser Ala Cys Ile Pro Arg Tyr Leu Tyr 65 70 75 80 Asn Ile Ala Thr Gly Asp Arg Ser Ile Thr Tyr Asn Ile Cys Val Ile 85 90 95 Gln Val Phe Phe Thr Asp Val Phe Gly Val Thr Glu Phe Phe Leu Leu 100 105 110 Ala Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu Gln 115 120 125 Tyr Val Thr Ile Met Asn Asn Arg Val Cys Lys Arg Leu Val Leu Cys 130 135 140 Cys Trp Met Ala Gly Leu Leu Ile Ile Leu Pro Pro Leu Thr Leu Phe 145 150 155 160 Leu Asn Leu Lys Phe Cys Asp Ser Asn Val Ile Asp Tyr Phe Phe Cys 165 170 175 Asp Ala Ser Pro Ile Leu Lys Ile Ser Cys Ser Asp Thr Trp Leu Ile 180 185 190 Glu Gln Leu Val Ile Val Cys Ala Val Leu Thr Phe Ile Leu Thr Leu 195 200 205 Val Cys Val Leu Gln Ser Tyr Ile Ser Ile Ile Lys Thr Ile Leu Gln 210 215 220 Phe Pro Ser Thr Gln Gln Arg Lys Arg Ala Phe Ser Thr Cys Ser Ser 225 230 235 240

Page 3082

069269_0225_SL.TXT

His Met Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile Tyr 245 250 255 Val Asn Pro Ser Ala Lys Glu Ser Val Thr Ile Asn Lys Gly Val Thr 260 265 270 Val Leu Met Thr Ser Ile Ala Pro Met Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Lys Gln Val Arg Gln Ala Phe Ser Asp Ser Phe Lys Lys 290 295 300

Ile Ala Xaa 305 <210> 2773 <211> 936 <212> DNA <213> Felis catus <400> 2773

atgagcaacc agacaataac aaccttcatt ctcctcggac tgacagatga ccctcaattt 60 cagattccaa tttttatgtt tctatttctc acttacatgt taagtataac tgggaatctg 120 accattatat tcctcacttt gctcgactcc caccttaaaa cacccatgta ctttttccta 180 cagaattttg ccttattaga aatttcattt acatctgctt gtattcctag atatttatac 240 aacatagcaa caggtgatag atcaataact tacaatattt gtgtcactca agtgtttttt 300 attgatgcat ttggggtaac agaattttat cttttggcca tcatgtctta tgatcgctat 360 gtggccatct gcaaacccct gcattatgta accatcatca acaacaaagt ttgcagaagg 420 tttgtcctct gctgctggac agctggtgtg ttgatcatac tcgcaccact tatcatgata 480 gtaaatctag aattctgtga ctcgaatgtc attgattatt tcttctgtga ttcatatcct 540 atattgaaga tatcatgctc agacacctgg cttttagagc agatggtgat aacctgtgct 600 gtactggcct tcatcacaac ccttctgtgt gttgttctgt cctatatctg cattatcaag 660 actattctac aattcccctc tgcccagcaa agaaaaaggg ccttttctac ctgttcttct 720 cacatgattg ttgtttccat tacatatgga agctgtattt tcatctatgt taaaccttca 780

Page 3083

069269_0225_SL.TXT gcaaaggaat cagtggctat taataagagt gtgacagtgc taatgacatc catagctccc atgttgaacc cattcattta cactctgaga aacaaacaag tgagacaagc tttcagtgac tcattcaaaa gaattgcatt accctcaaag aagtaa

840

900

936 <210> 2774 <211> 311 <212> PRT <213> Felis catus

<400> 2774 Ile Thr Thr Phe Ile Leu Leu Gly Leu Thr Asp Met Ser 1 Asn Gln Thr 5 10 15 Asp Pro Gln Phe Gln Ile Pro Ile Phe Met Phe Leu Phe Leu Thr Tyr 20 25 30 Met Leu Ser Ile Thr Gly Asn Leu Thr Ile Ile Phe Leu Thr Leu Leu 35 40 45 Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Gln Asn Phe Ala 50 55 60 Leu Leu Glu Ile Ser Phe Thr Ser Ala Cys Ile Pro Arg Tyr Leu Tyr 65 70 75 80 Asn Ile Ala Thr Gly Asp Arg Ser Ile Thr Tyr Asn Ile Cys Val Thr 85 90 95 Gln Val Phe Phe Ile Asp Ala Phe Gly Val Thr Glu Phe Tyr Leu Leu 100 105 110 Ala Ile Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His 115 120 125 Tyr Val Thr Ile Ile Asn Asn Lys Val Cys Arg Arg Phe Val Leu Cys 130 135 140 Cys Trp Thr Ala Gly Val Leu Ile Ile Leu Ala Pro Leu Ile Met Ile 145 150 155 160

Page 3084

069269_0225_SL.TXT

Val Asn Leu Glu Phe Cys Asp Ser Asn Val Ile Asp Tyr Phe Phe Cys 165 170 175 Asp Ser Tyr Pro Ile Leu Lys Ile Ser Cys Ser Asp Thr Trp Leu Leu 180 185 190 Glu Gln Met Val Ile Thr Cys Ala Val Leu Ala Phe Ile Thr Thr Leu 195 200 205 Leu Cys Val Val Leu Ser Tyr Ile Cys Ile Ile Lys Thr Ile Leu Gln 210 215 220 Phe Pro Ser Ala Gln Gln Arg Lys Arg Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Met Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile Tyr 245 250 255 Val Lys Pro Ser Ala Lys Glu Ser Val Ala Ile Asn Lys Ser Val Thr 260 265 270 Val Leu Met Thr Ser Ile Ala Pro Met Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Lys Gln Val Arg Gln Ala Phe Ser Asp Ser Phe Lys Arg 290 295 300 Ile Ala Leu Pro Ser Lys Lys

305 310 <210> 2775 <211> 882 <212> DNA <213> Felis catus <400> 2775 attcttttgg gtctgacaaa tgaccctgta ctgcaggttg taattttcct ctttctattt tttacctact tgttgagtgt gacaggaaac ttaaccatca tcactctcac tctgctggat

120

Page 3085

069269_0225_SL.TXT

tcccacctaa agataccaat gtacttcttc ctacggaatt tctccttttt agaaatctca 180 ttcacaactg tttgtattcc aaggttcctg gtgagccttg tgacaaagga caggactatt 240 tcctacatga gctgtatgac tcagttattt tttgtatctt tttgggagta actgaatttt 300 accttctggc tgctatgtcc ttcgaccgtt atgtggctat atgtaaacct ctgcattaca 360 ccaccatcat gagcaacaaa gtttgctacc aacttgtact cagctcttgg gtaactggat 420 tcttggtcat ctttcctcca ataatcttgg gactcaagtt ggaattttgt gcttccaatg 480 tcattgatca ctttatttgt gattcttctc ccatcctgca gatctcttgt tcagatacac 540 atttcctaga gctaatgtca tttttcttgg ccgtgatgac actaatggtc acactgatgt 600 tagtgattct ctcctacggc tacatcatca agacaattct caaattccct tctgttcagc 660 aaaggactaa agccttttct acctgttcct cccacatgat tgtagtttcc atctcttatg 720 gtagctgcat cttcatgtac ataaaaccat cagcaaatga cagagtgact ttaagcaaag 780 gagtagctgt gctcaatacc tcagttgccc ccttattgaa tcccttcatt tatacactaa 840 gaaaccaaca agtgaaacag gcctttaagg atatggtcca ga 882

<210> 2776 <211> 190 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (190)..(190) <223> Any amino acid

<400> 2776 Met 1 Ser Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Thr 5 10 15 Thr Ile Met Ser Asn Lys Val Cys Tyr Gln Leu Val Leu Ser Ser Trp 20 25 30 Val Thr Gly Phe Leu Val Ile Phe Pro Pro Ile Ile Leu Gly Leu Lys 35 40 45 Leu Glu Phe Cys Ala Ser Asn Val Ile Asp His Phe Ile Cys Asp Ser Page 3086

069269_0225_SL.TXT

Ser Pro Ile Leu Gln Ile Ser Cys Ser Asp Thr His Phe Leu Glu Leu 65 70 75 80 Met Ser Phe Phe Leu Ala Val Met Thr Leu Met Val Thr Leu Met Leu 85 90 95 Val Ile Leu Ser Tyr Gly Tyr Ile Ile Lys Thr Ile Leu Lys Phe Pro 100 105 110 Ser Val Gln Gln Arg Thr Lys Ala Phe Ser Thr Cys Ser Ser His Met 115 120 125 Ile Val Val Ser Ile Ser Tyr Gly Ser Cys Ile Phe Met Tyr Ile Lys 130 135 140 Pro Ser Ala Asn Asp Arg Val Thr Leu Ser Lys Gly Val Ala Val Leu 145 150 155 160 Asn Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr Thr Leu Arg 165 170 175 Asn Gln Gln Val Lys Gln Ala Phe Lys Asp Met Val Gln Xaa 180 185 190

<210> 2777 <211> 928 <212> DNA <213> Felis catus <400> 2777

atgaaaaatc attctgcaat aacattcatt ctactaggat tgacagataa cccactacta 60 caggtttttc tttcagtatt tctgtttttc acctacattt tcactgttac tggaaatcta 120 atcattattc tcctcactct ggttgactct cacctcaaaa cacccatgta ctttttcctt 180 tggaattttt ccattttaga aataatattt acaactgcct gtgttcctag attcctgtac 240 agcctgacaa ctggggacaa aagtgttacc tataatgctt gtgccatcca attctttttt 300 gccatcctca tcggagcaac agaatttttt cttctaactg tatgtgctat gatcactatg 360

Page 3087

069269_0225_SL.TXT

tggccatctg caaacccctg cactacagta ccatcatgag tgaaagagta tgcatcatgt 420 ttgtcctttg ttgttggctg attgggttgt catactccca ccgcttagcc tgggagtcca 480 gctagatttc agtaactcta atctcattga ccattttggc tgtgatgcat ctcctcttct 540 gaagattgta tgctcagaca ccaatttgta gagcaactta ttttaatcat ggctgtgctg 600 accctcatag tcacattatt ctgtgtaatt atgtcctaca catacatcat caagactatt 660 ttaagactcc cttcagctca gcaaagaaaa aagcctttct tcacttgttc ttcccacatg 720 atcatagtct ccatctgcct atggaagatg catcttcatc tatatcagac cagcaaagga 780 aggagttgcc attaataagg tggtgtcatt gctcaaaacc tcagttatcc cattgataaa 840 ctctttcatt tacacactac agaataagca agtcaaacaa gccttcaaat actcaattaa 900 aaagatggca tttctttcaa aggattag 928

<210> 2778 <211> 132 <212> PRT <213> Felis catus <400> 2778

Met 1 Lys Asn His Ser Ala 5 Ile Thr Phe Ile Leu Leu Gly Leu Thr Asp 10 15 Asn Pro Leu Leu Gln Val Phe Leu Ser Val Phe Leu Phe Phe Thr Tyr 20 25 30 Ile Phe Thr Val Thr Gly Asn Leu Ile Ile Ile Leu Leu Thr Leu Val 35 40 45 Asp Ser His Leu Lys Thr Pro Met Tyr Phe Phe Leu Trp Asn Phe Ser 50 55 60 Ile Leu Glu Ile Ile Phe Thr Thr Ala Cys Val Pro Arg Phe Leu Tyr 65 70 75 80 Ser Leu Thr Thr Gly Asp Lys Ser Val Thr Tyr Asn Ala Cys Ala Ile 85 90 95

Page 3088

069269_0225_SL.TXT

Gln Phe Phe Phe Ala Ile Leu Ile Gly Ala Thr Glu Phe Phe Leu Leu 100 105 110 Thr Val Cys Ala Met Ile Thr Met Trp Pro Ser Ala Asn Pro Cys Thr 115 120 125 Thr Val Pro Ser 130

<210> 2779 <211> 939 <212> DNA <213> Felis catus <400> 2779

atgagaaatt gcacagcagt aacaacattc atccttctgg gattaacaga tgaccccaaa 60 atacaagttc tgctttttgt atttttgttt ctcacctaca tgttgagtgt ggctggaaac 120 ctcatcatta tcaccctcac acttttggat tcccatctta aaactcctat gtatcttttc 180 ctccggaatt tctctttctt agaagtctca ttcaccactg tctgtattcc cagattcctg 240 tatatgatga caactggaga caatactgtt acctacaatg cttgcgccac ccaattattt 300 tttattgtcc tctttggagc aacagaattt tttctccttg ctgccatgtc gtatgaccgc 360 tatgtggcca tttgtaagcc cctgcactac acaaccatca tgaacaacag agtctgtact 420 accctcattc tctgctgttg gttcgctggc ctgttaatca tcctcccacc tcttggcatg 480 ggcctccagc tggaattctg tgactcaaat gtgattgatc attttggttg tgatgcatct 540 cctattttgc agataacctg ctcagacaca gtgttaatag agagaattgt tttgagtttt 600 gctgtgctga cactcattat tactttagtg tgtgtagtcc tctcctacac atacatcatt 660 aagaccattc tacaattccc ttctgcccaa caaaggaaaa aggccttttc cacctgctct 720 tcccatatga ttgtggtttc catcacttat ggcagctgta tcttcatcta catcaaacct 780 tcagcaaagg aaggggtagc tactaataaa gtagtgtctg tgctcactac ttcagttgcc 840 cctttgctta acccattcat ttatacactt cgaaacaaac aagtgaaaga tgccttcaaa 900 gacacagtaa aacggattgt atttctcacc aagaagtaa 939

<210> 2780

Page 3089

069269_0225_SL.TXT <211> 312 <212> PRT <213> Felis catus

<400> 2780 Ala Val Thr Met 1 Arg Asn Cys Thr 5 Asp Asp Pro Lys 20 Ile Gln Val Leu Tyr Met Leu 35 Ser Val Ala Gly Asn 40 Leu Asp 50 Ser His Leu Lys Thr 55 Pro Ser 65 Phe Leu Glu Val Ser 70 Phe Thr Tyr Met Met Thr Thr 85 Gly Asp Asn Thr Gln Leu Phe 100 Phe Ile Val Leu Leu Ala Ala 115 Met Ser Tyr Asp Arg 120 His Tyr 130 Thr Thr Ile Met Asn 135 Asn Cys 145 Cys Trp Phe Ala Gly 150 Leu Leu Gly Leu Gln Leu Glu 165 Phe Cys Asp Cys Asp Ala Ser 180 Pro Ile Leu Gln

Phe 10 Ile Leu Leu Gly Leu 15 Thr Phe Val Phe Leu Phe 30 Leu Thr Ile Ile Ile Thr 45 Leu Thr Leu Tyr Leu Phe 60 Leu Arg Asn Phe Val Cys 75 Ile Pro Arg Phe Leu 80 Val 90 Thr Tyr Asn Ala Cys 95 Ala Gly Ala Thr Glu Phe 110 Phe Leu Val Ala Ile Cys 125 Lys Pro Leu Val Cys Thr 140 Thr Leu Ile Leu Ile Leu 155 Pro Pro Leu Gly Met 160 Asn 170 Val Ile Asp His Phe 175 Gly Thr Cys Ser Asp Thr 190 Val Leu

Page 3090

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Ile Glu Arg Ile Val Leu Ser Phe Ala Val Leu Thr Leu Ile Ile Thr 195 200 205 Leu Val Cys Val Val Leu Ser Tyr Thr Tyr Ile Ile Lys Thr Ile Leu 210 215 220 Gln Phe Pro Ser Ala Gln Gln Arg Lys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Met Ile Val Val Ser Ile Thr Tyr Gly Ser Cys Ile Phe Ile 245 250 255 Tyr Ile Lys Pro Ser Ala Lys Glu Gly Val Ala Thr Asn Lys Val Val 260 265 270 Ser Val Leu Thr Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Lys Asp Ala Phe Lys Asp Thr Val Lys 290 295 300 Arg Ile Val Phe Leu Thr Lys Lys

305 310 <210> 2781 <211> 938 <212> DNA <213> Felis catus <400> 2781

atgaaaaatt atacagcaat aacaacattc atcctggtgg gactaacaga tgacccaaat 60 ctacagattc tgctttttat ttttttgttt ctaatttact tgttaagtgt tgtagggaat 120 ctgaccatca tcactctcac cttagtggat tcccacctta aaagtcccat gtattttttc 180 ctctggaatt tctccatctt ggaagtgtca tttacaactg tttgtattcc cagattcctc 240 tacacaatgg catctgagga caataacgtt acctacagtg catgtgccac tcaattattt 300 tttgttactg tcttgggtgt aactgagttt tttctcctga cagccatgtc ctatgactgc 360 tatgttgcca tctgcaaact cctgcattac ataaccttca tgaataacag ggtctgcatc 420

Page 3091

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aagttcctga ttggaacctg catcattgct ctgatcattg tcatcccacc atttggcatg 480 ggcttgagct caagttttgt gactccaatg tcatatatca ctttggctat gatgctactt 540 ccatcctgaa gattaccggc tcagacacag agtttataga gcaatttgtc ttggtcctgg 600 ctgtgctgac actcattttc accttggtgt gtgtaattat gtcctacaca tacatcatca 660 ggaccattct cagattccct tctgcccagc aaaggaaaaa ggctttttct acttgttctc 720 cccatataat tgtggtttct attacttatg gaagatgcat ctttatctat atcaaacctc 780 atgcaaaaga aggggttgct attaataagc tggtgtcagt gcttaccacc tccattgccc 840 cagtgatgaa tcccttcatt tatactctga ggaacaagca agtagtacaa gctttcaaag 900 acatgatctg aaaggttaca tctatctcaa ataactaa 938

<210> 2782 <211> 182 <212> PRT <213> Felis catus

<400> 2782 Thr Ala 5 Ile Thr Thr Phe Ile Leu Val Gly Leu Thr Met 1 Lys Asn Tyr 10 15 Asp Asp Pro Asn Leu Gln Ile Leu Leu Phe Ile Phe Leu Phe Leu Ile 20 25 30 Tyr Leu Leu Ser Val Val Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Val Asp Ser His Leu Lys Ser Pro Met Tyr Phe Phe Leu Trp Asn Phe 50 55 60 Ser Ile Leu Glu Val Ser Phe Thr Thr Val Cys Ile Pro Arg Phe Leu 65 70 75 80 Tyr Thr Met Ala Ser Glu Asp Asn Asn Val Thr Tyr Ser Ala Cys Ala 85 90 95 Thr Gln Leu Phe Phe Val Thr Val Leu Gly Val Thr Glu Phe Phe Leu 100 105 110

Page 3092

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Leu Thr Ala Met Ser Tyr Asp Cys Tyr Val Ala Ile Cys 125 Lys Leu Leu 115 120 His Tyr Ile Thr Phe Met Asn Asn Arg Val Cys Ile Lys Phe Leu Ile 130 135 140 Gly Thr Cys Ile Ile Ala Leu Ile Ile Val Ile Pro Pro Phe Gly Met 145 150 155 160 Gly Leu Ser Ser Ser Phe Val Thr Pro Met Ser Tyr Ile Thr Leu Ala 165 170 175 Met Met Leu Leu Pro Ser

180 <210> 2783 <211> 932 <212> DNA <213> Felis catus <400> 2783 ttctttgaaa gaaatgcaag tcttttaagg atgtcatgga aagaccgcct tacttgtgta tttctcagag tataaatgaa ggggttcaac aaaggggcaa cagatgtagt gagcagagaa actgccttat taatggccac ttcatcctta gctgaaggtt tgatatacat aaaaatgcag ctgccatagg tgacagaaac cacaatcatg tgggaagaac aggtggaaaa ggcttttttc ttttgctggg cagaaggtaa tcttagaatt gtcctaatga tgtatatgta ggacagaact atacacacaa gggtcattat gaaggtcaac acagcacaga ctatgaccag ctgctctatg aaccatgtat ctgaacatga atttttcagt atcggagaag catcacagac aaaatggtca atatcagagt cacagaattc cagatggagg ctcaaaccaa ggggtggaaa gataatcaat aagccagaca cccaacaaga caggataaga ttccaacaga ctctgttgtt catgatggtc acgtaatgca ggggtttgca gatggccaca tagcggtcgt aggacatcac agccaagagg aaaaattctg tagctccaaa gagaacaata aaaaagattt ggctgaagca ggccttgatg gtgatggttt tgtccccact tgatatcatg tacaggtatg tggggacaca ggcagttgtg

120

180

240

300

360

420

480

540

600

660

720

Page 3093

069269_0225_SL.TXT aatgagattt ctaagaagga gaaattttga agaaaaagat acatagctgt ttttaaatga gaatccacca agatgagaga aattatggtc agattcccaa ttacacttat catatatgtg ataaacagaa agataaaaac cagaatctct agttgtgggt catttgtcaa acccagtatg atgaacattg ttattgccga atggtttctc at

780

840

900

932 <210> 2784 <211> 311 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (311)..(311) <223> Any amino acid

<400> 2784 Ala Ile Thr Met Phe Ile Ile Leu Gly Leu Thr Met 1 Arg Asn His Ser 5 10 15 Asn Asp Pro Gln Leu Glu Ile Leu Val Phe Ile Phe Leu Phe Ile Thr 20 25 30 Tyr Met Ile Ser Val Ile Gly Asn Leu Thr Ile Ile Ser Leu Ile Leu 35 40 45 Val Asp Ser His Leu Lys Thr Ala Met Tyr Leu Phe Leu Gln Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Phe Thr Thr Ala Cys Val Pro Thr Tyr Leu 65 70 75 80 Tyr Met Ile Ser Ser Gly Asp Lys Thr Ile Thr Ile Lys Ala Cys Phe 85 90 95 Ser Gln Ile Phe Phe Ile Val Leu Phe Gly Ala Thr Glu Phe Phe Leu 100 105 110 Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125

Page 3094

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His Tyr 130 Val Thr Ile Met Asn Asn Arg Val Cys Trp Asn Leu Ile Leu 135 140 Ser Cys Trp Val Ser Gly Leu Leu Ile Ile Phe Pro Pro Leu Gly Leu 145 150 155 160 Ser Leu His Leu Glu Phe Cys Asp Ser Asp Ile Asp His Phe Val Cys 165 170 175 Asp Ala Ser Pro Ile Leu Lys Asn Ser Cys Ser Asp Thr Trp Phe Ile 180 185 190 Glu Gln Leu Val Ile Val Cys Ala Val Leu Thr Phe Ile Met Thr Leu 195 200 205 Val Cys Ile Val Leu Ser Tyr Ile Tyr Ile Ile Arg Thr Ile Leu Arg 210 215 220 Leu Pro Ser Ala Gln Gln Lys Lys Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Met Ile Val Val Ser Val Thr Tyr Gly Ser Cys Ile Phe Met Tyr 245 250 255 Ile Lys Pro Ser Ala Lys Asp Glu Val Ala Ile Asn Lys Ala Val Ser 260 265 270 Leu Leu Thr Thr Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Thr Gln Val Arg Arg Ser Phe His Asp Ile Leu Lys Arg 290 295 300 Leu Ala Phe Leu Ser Lys Xaa

305 310 <210> 2785 <211> 920 <212> DNA

Page 3095

069269_0225_SL.TXT <213> Felis catus <400> 2785 caatgaaaaa taaaccaggt tgactgaatg tatcctgctg ggtctaacag atgtccctga 60 actccaggtg gtggttttca cctttatgtt ccttgcttat ttactcagca tcatcagaaa 120 tctgactatc ctcatcctca ccttgctgga ctcccacctt cagactccca tgtatttctt 180 tctctggaac ttctctttat tagaaatgtc cttcacaaac attttcattc ccagggtcct 240 gatcagcatc acaacaggga ataagagtat cagtttagct ggctgcttca ctcagtattt 300 ctttgcaata ttccttgggg caacagagtt ttatcttctg gctgccatgt cctatgaccg 360 ctatgtgacc atatgcaaac ccctgcatta catggccatt atgagcagca gagtttgtac 420 ccaaatggtt ctctactctt ggctggctgg gttactggtt attataccac taatccctct 480 gatgagtcaa caggactttt gtgcatccaa caggctgaat cattatttct gtgactatga 540 gcccctttgg aaactctcct gttcagacac aagcctcatc aagaaggttg tctttcttgt 600 ggcatctgtg accctactgg tcactctgac tgctgactct ctcctatatg ttcataatca 660 ggattattct gaagctcccc tcagggagca aaggacaaaa gccttttcca cctgttcttc 720 ccatatgacc atgatctctc cctcctatgg aagctgcttc ttcacattca ttaacccctc 780 agcaaaaaaa aaaggacaca gttaacaagg gagtagctct actcattact acagtcacac 840 ctttattgaa ccccttcatt tatgccctaa ggaaccaaca ggtaaacaag ctttcaagga 900 tatagtcaaa aagcttgtga 920 <210> 2786 <211> 20 <212> PRT <213> Felis catus <400> 2786

Thr Ser Phe Leu Thr Ile Ser Leu Lys Ala Cys Leu Pro Val Gly Ser 1 5 10 15

Leu Gly His Lys 20 <210> 2787 <211> 935

Page 3096

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 2787

gttagcaatg aaaaaccaaa cctttctgac agaattcatt cttctgggac tatcagacat 60 cccggagatc caacttgtaa tctttatatt tctcttcctc acctacatat tcagcatcat 120 tggaaacctg acaatcatca cccttactct actggattcc cacctccaga ctcccatgta 180 tttcttcctc cggaacttct ccttcttaga aatttccttt acaaccactt ttactcccag 240 gctgctgttc agcatcacaa ctggaaacaa gagcatcagc tttgctggct gcttcacaca 300 gtatttcttt gccatcttct ttggagccac agagttttac cttctggctg ccatgtcctt 360 tgaccgctat gtggccatat gcaaacccct gcattacatg accattatga gcagcagagt 420 ctgcatccag ctggtcctct gctcttggtt ggctggattc ctaatcatca tatccccaat 480 catcctgacc agtcagctgg atttctgtgc ctccaacatg ctgaatcatt attactgtga 540 ctatggaccc ctcctagaaa tatcttgctc agacacaaga ttcctggagc tggttgactt 600 tatcttagca gttgtgacct tggtggtcac tctgatgcta gtgattctct cctacacaaa 660 catcatctgg accattctca agatcccctc agctcagcaa aggaaaaagg ctttttccac 720 gtgtttttcc cacatgattg tcatctccct ctcttatggc agctgcatct tcatgtacat 780 aaaaccctca gctaaagaag gagttgcctt caataagggg gtagctgtgc tcaataactc 840 agttgcccct ttattgaacc cattcattta caccttaagg aacaaacaag taaaacaagc 900 cttcaaggat gtggccagaa agattatgag tattt 935

<210> 2788 <211> 310 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (310)..(310) <223> Any amino acid <400> 2788

Met Lys Asn Gln Thr Phe Leu Thr Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15

Page 3097

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Asp Ile Pro Glu 20 Ile Gln Leu Val Ile Phe Ile Phe Leu Phe Leu Thr 25 30 Tyr Ile Phe Ser Ile Ile Gly Asn Leu Thr Ile Ile Thr Leu Thr Leu 35 40 45 Leu Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe 50 55 60 Ser Phe Leu Glu Ile Ser Phe Thr Thr Thr Phe Thr Pro Arg Leu Leu 65 70 75 80 Phe Ser Ile Thr Thr Gly Asn Lys Ser Ile Ser Phe Ala Gly Cys Phe 85 90 95 Thr Gln Tyr Phe Phe Ala Ile Phe Phe Gly Ala Thr Glu Phe Tyr Leu 100 105 110 Leu Ala Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Ser Ser Arg Val Cys Ile Gln Leu Val Leu 130 135 140 Cys Ser Trp Leu Ala Gly Phe Leu Ile Ile Ile Ser Pro Ile Ile Leu 145 150 155 160 Thr Ser Gln Leu Asp Phe Cys Ala Ser Asn Met Leu Asn His Tyr Tyr 165 170 175 Cys Asp Tyr Gly Pro Leu Leu Glu Ile Ser Cys Ser Asp Thr Arg Phe 180 185 190 Leu Glu Leu Val Asp Phe Ile Leu Ala Val Val Thr Leu Val Val Thr 195 200 205 Leu Met Leu Val Ile Leu Ser Tyr Thr Asn Ile Ile Trp Thr Ile Leu 210 215 220

Page 3098

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Lys 225 Ile Pro Ser Ala Gln 230 Gln Arg Lys Lys Ala Phe Ser Thr Cys Phe 235 240 Ser His Met Ile Val Ile Ser Leu Ser Tyr Gly Ser Cys Ile Phe Met 245 250 255 Tyr Ile Lys Pro Ser Ala Lys Glu Gly Val Ala Phe Asn Lys Gly Val 260 265 270 Ala Val Leu Asn Asn Ser Val Ala Pro Leu Leu Asn Pro Phe Ile Tyr 275 280 285 Thr Leu Arg Asn Lys Gln Val Lys Gln Ala Phe Lys Asp Val Ala Arg 290 295 300 Lys Ile Met Ser Ile Xaa

305 310 <210> 2789 <211> 927 <212> DNA <213> Felis catus <400> 2789

atgaaaaata ggacgtttag tgagttcatc ctgttgggct tcacaaatca acctgaggtc 60 caagttgtga tattcatctt tctgctcctc acgtatgtga taagtgtcct aggaaatctg 120 actatcatca ttctcactcg ggtacaccct cacctccaga cccccatgta tttcttcctc 180 cggaatttct ccttcttaga aatttccttc acatccattt ttattcccag atttctgacc 240 agcgtgacaa caggaaataa agtcatcagt tttgctggat gcttcattca atattttttt 300 gctatattcc ttggggcaac agagttttac ctcttggctt ctatgtccta tgaccgctat 360 gttgctatct gcaaacccct gcattacctg accatcatga gcaacagagt ctgcatacaa 420 cttgtgttct gctcctggct ggggggattg ctagctatct tacccccaat caccttgatg 480 agccaggtgg atttctgtgc ctccaatgtt ctgaatcact attactgtga ctatgggccc 540 cttctggagc ttgcctgctc agacacaagc ctcctagaac agatggtcat ctttgtggcg 600 gttgtgactc tggtggttac cctggtgctg gtgacatttt cttatacata cattatcaag 660

Page 3099

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accattttga ggatcccttc tgcccagcaa aggacaaagg ctttttccac ttgttcttcc 720 cacatgattg tcatctccct ctcttatggc agctgcatgt ttatgtacat caatccatca 780 gcaaaagaag aaggcgcttt caacaaagga atagctgtgc tcattacctc aattactccc 840 ttattaaacc ccttcattta cactctaaga aatcagcaag tgaagcaagc attcaaggac 900 accatcaaga agattatgaa gctttaa 927

<210> 2790 <211> 308 <212> PRT <213> Felis catus <400> 2790

Met 1 Lys Asn Arg Thr Phe Ser Glu Phe Ile Leu Leu Gly Phe Thr Asn 5 10 15 Gln Pro Glu Val Gln Val Val Ile Phe Ile Phe Leu Leu Leu Thr Tyr 20 25 30 Val Ile Ser Val Leu Gly Asn Leu Thr Ile Ile Ile Leu Thr Arg Val 35 40 45 His Pro His Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg Asn Phe Ser 50 55 60 Phe Leu Glu Ile Ser Phe Thr Ser Ile Phe Ile Pro Arg Phe Leu Thr 65 70 75 80 Ser Val Thr Thr Gly Asn Lys Val Ile Ser Phe Ala Gly Cys Phe Ile 85 90 95 Gln Tyr Phe Phe Ala Ile Phe Leu Gly Ala Thr Glu Phe Tyr Leu Leu 100 105 110 Ala Ser Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His 115 120 125 Tyr Leu Thr Ile Met Ser Asn Arg Val Cys Ile Gln Leu Val Phe Cys

130 135 140

Page 3100

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Ser 145 Trp Leu Gly Gly Leu 150 Leu Ala Ile Leu Pro Pro Ile Thr Leu Met 155 160 Ser Gln Val Asp Phe Cys Ala Ser Asn Val Leu Asn His Tyr Tyr Cys 165 170 175 Asp Tyr Gly Pro Leu Leu Glu Leu Ala Cys Ser Asp Thr Ser Leu Leu 180 185 190 Glu Gln Met Val Ile Phe Val Ala Val Val Thr Leu Val Val Thr Leu 195 200 205 Val Leu Val Thr Phe Ser Tyr Thr Tyr Ile Ile Lys Thr Ile Leu Arg 210 215 220 Ile Pro Ser Ala Gln Gln Arg Thr Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Met Ile Val Ile Ser Leu Ser Tyr Gly Ser Cys Met Phe Met Tyr 245 250 255 Ile Asn Pro Ser Ala Lys Glu Glu Gly Ala Phe Asn Lys Gly Ile Ala 260 265 270 Val Leu Ile Thr Ser Ile Thr Pro Leu Leu Asn Pro Phe Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Gln Val Lys Gln Ala Phe Lys Asp Thr Ile Lys Lys 290 295 300 Ile Met Lys Leu

305 <210> 2791 <211> 699 <212> DNA <213> Felis catus <400> 2791

Page 3101

069269_0225_SL.TXT

accgtcatcg tgcccaagat gttgctcaac attgccacag ggaccaagac catcagtttt 60 gctggctgca ttactcagga ctttttccac atcttcctgg gggctacaga gttcctcctc 120 ctcacagcca tggcctatga ccggtatatt gccatctgcc agcccctcca ctaccccatc 180 ctcatgagca acagagtctg cacacagctt atcctcacct gctggctggc aggattcttc 240 ttcatcatag tgcctgtcat cctgaccagt cagcttccat tctgtgacac ccacatcaac 300 cacttcttct gcgactatac gcctctaatg gaggtggtgt gcagtgggcc acaggtgtta 360 gagatggtgg attttaccct ggccgtggtg gcactgatca gcactctagt gctgatcacc 420 atatcctatg tccagatcat ccggacaatt gtcaggatcc cctcggtcca ggagagaaag 480 aaagctttct ccacctgttc ctcccatatc attgtggtca ccctgtgcta tggcagctgc 540 ttcttcatgt atgtgaagcc ctctcctggc aagggggttg atttcaacaa aggagtgtcc 600 ctaatcaata caattattgc ccccctcttg aatcccttta tctacactct caggaaccaa 660 caagttaagc aagtagtgaa agacctgatc aggaaaatg 699 <210> 2792 <211> 233 <212> PRT <213> Felis catus <400> 2792 Thr Val Ile Val Pro Lys Met Leu Leu Asn Ile Ala Thr Gly Thr Lys 1 5 10 15 Thr Ile Ser Phe Ala Gly Cys Ile Thr Gln Asp Phe Phe His Ile Phe 20 25 30 Leu Gly Ala Thr Glu Phe Leu Leu Leu Thr Ala Met Ala Tyr Asp Arg 35 40 45 Tyr Ile Ala Ile Cys Gln Pro Leu His Tyr Pro Ile Leu Met Ser Asn 50 55 60 Arg Val Cys Thr Gln Leu Ile Leu Thr Cys Trp Leu Ala Gly Phe Phe 65 70 75 80 Phe Ile Ile Val Pro Val Ile Leu Thr Ser Gln Leu Pro Phe Cys Asp

Page 3102

069269_0225_SL.TXT

85 90 95

Thr His Ile Asn 100 His Phe Phe Cys Asp Tyr Thr Pro Leu Met Glu Val 105 110 Val Cys Ser Gly Pro Gln Val Leu Glu Met Val Asp Phe Thr Leu Ala 115 120 125 Val Val Ala Leu Ile Ser Thr Leu Val Leu Ile Thr Ile Ser Tyr Val 130 135 140 Gln Ile Ile Arg Thr Ile Val Arg Ile Pro Ser Val Gln Glu Arg Lys 145 150 155 160 Lys Ala Phe Ser Thr Cys Ser Ser His Ile Ile Val Val Thr Leu Cys 165 170 175 Tyr Gly Ser Cys Phe Phe Met Tyr Val Lys Pro Ser Pro Gly Lys Gly 180 185 190 Val Asp Phe Asn Lys Gly Val Ser Leu Ile Asn Thr Ile Ile Ala Pro 195 200 205 Leu Leu Asn Pro Phe Ile Tyr Thr Leu Arg Asn Gln Gln Val Lys Gln 210 215 220 Val Val Lys Asp Leu Ile Arg Lys Met 225 230

<210> 2793 <211> 960 <212> DNA <213> Felis catus <400> 2793 atgacaccac ttgaaatgaa caatcagaca gatgtcactg aattcatctt cttgggattt tccaaccacc ccaaactaca gggcttgttt ttcctggttt tcttgctcat ttacctgaca acactcctgg ggaacatgct cattataaca gccactagaa tcagtcctgc tctccacact ccaatgtatt atttcctcag caacctgagt ttcttggaca tctgttatac atccaccacc

120

180

240

Page 3103

069269_0225_SL.TXT

atccccgtca tgctggtgaa cttcttccgg gagaagaaga ccatctcata tgagggctgc 300 ctctcccaga ttttcttcct cgtcacatgt gctggcactg aatgtgtctt attggccgct 360 atggcttatg atcgctatgt agccatttgc caccctcttc aatatcccgt cctcatgcgt 420 gtgaaggtct gtattttttt ggtggctggg tcctggctgt gtgggctggt gaattctgtg 480 acacacacag tgctggcagc cacactgact ctctgtgggc ccaaccaaat cagccacttt 540 ctctgtgaca ttcctctgct cctgaagctc tcctgttcag acacctctct caatgagtct 600 gtgcttcatg tggccagtgc caccattggc ctgagcccct gtctgtttac tggagtgtcc 660 tacatactca tcatttcttc cattcttagg attccctctg ctcagggcag gagcaaagcc 720 ttctctacct gcgcatccca cctcactgtg gtggtggtct tttatggaac agccaacttt 780 aactatgaca gacccagaga aggttactcc ctagacatgg atattctggt ttctgtgctc 840 ttctgtgtta tgactcccat gttgaacccc atcatataca gcctgagaaa caaggaggtc 900 aagggtgctc tgaggaagct ggctggaggg tatatgatcc ctggcaatat tagtgtctag 960

<210> 2794 <211> 319 <212> PRT <213> Felis catus

<400> 2794 Met Thr Pro Leu 1 Glu 5 Met Asn Asn Gln Thr Asp Val Thr Glu Phe Ile 10 15 Phe Leu Gly Phe Ser Asn His Pro Lys Leu Gln Gly Leu Phe Phe Leu 20 25 30 Val Phe Leu Leu Ile Tyr Leu Thr Thr Leu Leu Gly Asn Met Leu Ile 35 40 45 Ile Thr Ala Thr Arg Ile Ser Pro Ala Leu His Thr Pro Met Tyr Tyr 50 55 60 Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Thr Thr 65 70 75 80

Page 3104

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Ile Pro Val Met Leu Val Asn Phe Phe Arg Glu Lys Lys Thr Ile 95 Ser 85 90 Tyr Glu Gly Cys Leu Ser Gln Ile Phe Phe Leu Val Thr Cys Ala Gly 100 105 110 Thr Glu Cys Val Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Gln Tyr Pro Val Leu Met Arg Val Lys Val Cys 130 135 140 Ile Phe Leu Val Ala Gly Ser Trp Leu Cys Gly Leu Val Asn Ser Val 145 150 155 160 Thr His Thr Val Leu Ala Ala Thr Leu Thr Leu Cys Gly Pro Asn Gln 165 170 175 Ile Ser His Phe Leu Cys Asp Ile Pro Leu Leu Leu Lys Leu Ser Cys 180 185 190 Ser Asp Thr Ser Leu Asn Glu Ser Val Leu His Val Ala Ser Ala Thr 195 200 205 Ile Gly Leu Ser Pro Cys Leu Phe Thr Gly Val Ser Tyr Ile Leu Ile 210 215 220 Ile Ser Ser Ile Leu Arg Ile Pro Ser Ala Gln Gly Arg Ser Lys Ala 225 230 235 240 Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Val Val Phe Tyr Gly 245 250 255 Thr Ala Asn Phe Asn Tyr Asp Arg Pro Arg Glu Gly Tyr Ser Leu Asp 260 265 270 Met Asp Ile Leu Val Ser Val Leu Phe Cys Val Met Thr Pro Met Leu 275 280 285

Page 3105

069269_0225_SL.TXT Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Leu 290 295 300

Arg Lys Leu Ala Gly Gly Tyr Met Ile Pro Gly Asn Ile Ser Val 305 310 315

<210> 2795 <211> 938 <212> DNA <213> Felis catus <400> 2795

ctaccgtgaa aatcgaccta gcccaagacc tttttcaagg cagccttaaa ttctttgttc 60 ctcaggcagt agatcaaggg gttgattatt ggggtgagga ccgtgtacac agcagagacg 120 agcttgttgg agctccggga gtcaatggcc tggggccgga cgtacatgaa aagcaaggcc 180 gtatagaaga tggtgaccac ggtgaggtgg gacgcacagg tggagaaggc cctccagcgg 240 ccagtggccg aggggatgcg caggacggcc agggcgatgt gcccgtacga cagcacggtg 300 gccacgagcg gcagcaccag gatgacaaag gccacgacga agtccaccag ctctgcggtc 360 gagaagtctg tgcaggccag tttgaggatg ggggagatgt cacagaagaa gtggttcagg 420 acattggagc cacagaacgt ggcgctggag ataaagtaca ccttgatcac ggagacggag 480 aagccgcacg cgaaggagaa ggccaccagc cggacgcaga gccccgtggt catgatggcg 540 tggtagcgca gggggtggca gatggccacg tggcggtcat aggccatgga ggccaggagc 600 acgcactcgg tgcataccaa ggagctgaag aaatagagct gggtcatgca tccgacaaag 660 gagatgcact tccgctgcag gaggagaccg tccagcatct tggggacgat ggcagacacg 720 tagcagatct ccagggcgga cagggcgccc aggaagtagt acatgggcct gtgcagggag 780 gagctgctcc ggacggcgag caggacggcc aggttctccg ccaggacgaa gaggtaggtg 840 agcaggaaga ggaggaacag cacaggctgc agcccagggg ccgtggggaa gcccagcagg 900 acgaacgcgc tgaccgtgct gccgttctgt cccctcat 938

<210> 2796 <211> 312 <212> PRT <213> Felis catus

Page 3106

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<400> 2796 Asp Leu Ala Gln Asp Leu Phe Gln Gly Ser Leu Lys 15 Thr 1 Val Lys Ile 5 10 Phe Phe Val Pro Gln Ala Val Asp Gln Gly Val Asp Tyr Trp Gly Glu 20 25 30 Asp Arg Val His Ser Arg Asp Glu Leu Val Gly Ala Pro Gly Val Asn 35 40 45 Gly Leu Gly Pro Asp Val His Glu Lys Gln Gly Arg Ile Glu Asp Gly 50 55 60 Asp His Gly Glu Val Gly Arg Thr Gly Gly Glu Gly Pro Pro Ala Ala 65 70 75 80 Ser Gly Arg Gly Asp Ala Gln Asp Gly Gln Gly Asp Val Pro Val Arg 85 90 95 Gln His Gly Gly His Glu Arg Gln His Gln Asp Asp Lys Gly His Asp 100 105 110 Glu Val His Gln Leu Cys Gly Arg Glu Val Cys Ala Gly Gln Phe Glu 115 120 125 Asp Gly Gly Asp Val Thr Glu Glu Val Val Gln Asp Ile Gly Ala Thr 130 135 140 Glu Arg Gly Ala Gly Asp Lys Val His Leu Asp His Gly Asp Gly Glu 145 150 155 160 Ala Ala Arg Glu Gly Glu Gly His Gln Pro Asp Ala Glu Pro Arg Gly 165 170 175 His Asp Gly Val Val Ala Gln Gly Val Ala Asp Gly His Val Ala Val 180 185 190 Ile Gly His Gly Gly Gln Glu His Ala Leu Gly Ala Tyr Gln Gly Ala 195 200 205

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Glu Glu Ile Glu Leu Gly His Ala Ser Asp Lys Gly Asp Ala Leu Pro 210 215 220 Leu Gln Glu Glu Thr Val Gln His Leu Gly Asp Asp Gly Arg His Val 225 230 235 240 Ala Asp Leu Gln Gly Gly Gln Gly Ala Gln Glu Val Val His Gly Pro 245 250 255 Val Gln Gly Gly Ala Ala Pro Asp Gly Glu Gln Asp Gly Gln Val Leu 260 265 270 Arg Gln Asp Glu Glu Val Gly Glu Gln Glu Glu Glu Glu Gln His Arg 275 280 285 Leu Gln Pro Arg Gly Arg Gly Glu Ala Gln Gln Asp Glu Arg Ala Asp 290 295 300 Arg Ala Ala Val Leu Ser Pro His 305 310

<210> 2797 <211> 727 <212> DNA <213> Felis catus <400> 2797

ctcatctgtc attgccccca gtgccccggc caacttcttc tccccaccca aggtcatcac 60 ctttgctgtg ccacccagtt attcttcatc tccttactgg tcaccactga aggcttcctc 120 ctgggcgtca tggcctgtga ccatttcatg gccatctgca gccccccgtg ctaccccatc 180 accatgtgcc actctgtcta cactcacctg gtgctgggca cctactgtgg aggctgcctc 240 aactctgttg tgcagaccag tctcacattc cgcctcccat tctgcagctc caactgcatc 300 aaccacttct tctgtgacgt gtcccctctg ctccagcttg cctgtggcag cacagccatc 360 aacgaacttc tcgtttggca tctgtgggct catcattgtg ggtgtgacat ttgtagtcct 420 catctcctat ggctacatca cagtgaccat cctgaggatg cgctcaggag ctgggagacg 480 caaggtcttc tccacctgtg gctcccacgt gactgtagtg actctctttg ttgggactgt 540

Page 3108

069269_0225_SL.TXT ctttgtcatg tatgcccagc caggagccat tgagtccatg gagcagggca aggtggtctc tgtcttctac acgttggtca tcccaatgct caatcctctc atctacagtc ttcgaaacaa ggatgtgaag gaggccctgc agaggctggg ccagagacac atggtcacat gaaggatgtg ctggtgg

600

660

720

727 <210> 2798 <211> 236 <212> PRT <213> Felis catus <400> 2798

Ser Ser 1 Val Ile Ala Pro Ser Ala Pro Ala Asn Phe Phe Ser Pro 15 Pro 5 10 Lys Val Ile Thr Phe Ala Val Pro Pro Ser Tyr Ser Ser Ser Pro Tyr 20 25 30 Trp Ser Pro Leu Lys Ala Ser Ser Trp Ala Ser Trp Pro Val Thr Ile 35 40 45 Ser Trp Pro Ser Ala Ala Pro Arg Ala Thr Pro Ser Pro Cys Ala Thr 50 55 60 Leu Ser Thr Leu Thr Trp Cys Trp Ala Pro Thr Val Glu Ala Ala Ser 65 70 75 80 Thr Leu Leu Cys Arg Pro Val Ser His Ser Ala Ser His Ser Ala Ala 85 90 95 Pro Thr Ala Ser Thr Thr Ser Ser Val Thr Cys Pro Leu Cys Ser Ser 100 105 110 Leu Pro Val Ala Ala Gln Pro Ser Thr Asn Phe Ser Phe Gly Ile Cys 115 120 125 Gly Leu Ile Ile Val Gly Val Thr Phe Val Val Leu Ile Ser Tyr Gly 130 135 140

Page 3109

069269_0225_SL.TXT

Tyr Ile 145 Thr Val Thr Ile Leu Arg Met Arg Ser Gly Ala Gly Arg Arg 150 155 160 Lys Val Phe Ser Thr Cys Gly Ser His Val Thr Val Val Thr Leu Phe 165 170 175 Val Gly Thr Val Phe Val Met Tyr Ala Gln Pro Gly Ala Ile Glu Ser 180 185 190 Met Glu Gln Gly Lys Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro 195 200 205 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 210 215 220 Ala Leu Gln Arg Leu Gly Gln Arg His Met Val Thr

225 230 235 <210> 2799 <211> 946 <212> DNA <213> Felis catus <400> 2799

actcagaggc cttccttgaa cctgttaact tgaggaaagc cctcttcaca tctttgtttc 60 taaggctgta gatgatggga ttgagaaagg cagagataat attgtagaac agagccagtt 120 tcttgtcccg ctctggggag gcattggccc ctgggttcat gtacataaac atggcaggtc 180 cacagaacat ggtgaccaca gtgatgtggg aggcacaggt ggagaaggcc ttgagtcgac 240 cctgagctga gcggatcttc aagattgtgg caaagatgcg gacataagaa gccagaatga 300 aggagagggg aaccaggaga aggatgaagc ccaggataaa atctacttgg tcattgaggg 360 atgtgtctgc acaggccagc ttcagaacag cagggacctc acagaagaag tgattgatct 420 cattggggcc acagtagggc aggcgcattg tgaagacagt gtagactagg gaacagctga 480 taccccacag tccacaaaag atggccattg ccccacacag ccatggggtc atgataacct 540 tgtatctgag tggataacag atggccacat atctatcata ggccataaca gagaacagcc 600 agccctcagt gatgcccaac accagaaaga tgtacatctg ggccacacac ccaacatagg 660

Page 3110

069269_0225_SL.TXT agatagtttt cttctggcag atcagatgca ccaacatctg aggcacagta gtggtgacat agctcatgtc cagaatggag aggacactga ggaagaagta catgggtgtg tggaggcggg agtccaagtg aatcaaggtg acaatgagtc cattgcccac aagtgtagag aggtagagaa agaggaagat gttgaagagg attgtattaa tttgggaatc cctggagaag cccagaagga tgaattcaga cacagagctg tggttgtccc agggaaagtt ctgcat

720

780

840

900

946 <210> 2800 <211> 316 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (316)..(316) <223> Any amino acid <400> 2800

Met Gln Asn Phe Pro Trp Asp Asn His Ser Ser Val Ser Glu Phe Ile 1 5 10 15 Leu Leu Gly Phe Ser Arg Asp Ser Gln Ile Asn Thr Ile Leu Phe Asn 20 25 30 Ile Phe Leu Phe Leu Tyr Leu Ser Thr Leu Val Gly Asn Gly Leu Ile 35 40 45 Val Thr Leu Ile His Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Ser Val Leu Ser Ile Leu Asp Met Ser Tyr Val Thr Thr Thr 65 70 75 80 Val Pro Gln Met Leu Val His Leu Ile Cys Gln Lys Lys Thr Ile Ser 85 90 95 Tyr Val Gly Cys Val Ala Gln Met Tyr Ile Phe Leu Val Leu Gly Ile 100 105 110 Thr Glu Gly Trp Leu Phe Ser Val Met Ala Tyr Asp Arg Tyr Val Ala

Page 3111

115 069269_0225_SL.TXT 120 125 Ile Cys Tyr Pro Leu Arg Tyr Lys Val Ile Met Thr Pro Trp Leu Cys 130 135 140 Gly Ala Met Ala Ile Phe Cys Gly Leu Trp Gly Ile Ser Cys Ser Leu 145 150 155 160 Val Tyr Thr Val Phe Thr Met Arg Leu Pro Tyr Cys Gly Pro Asn Glu 165 170 175 Ile Asn His Phe Phe Cys Glu Val Pro Ala Val Leu Lys Leu Ala Cys 180 185 190 Ala Asp Thr Ser Leu Asn Asp Gln Val Asp Phe Ile Leu Gly Phe Ile 195 200 205 Leu Leu Leu Val Pro Leu Ser Phe Ile Leu Ala Ser Tyr Val Arg Ile 210 215 220 Phe Ala Thr Ile Leu Lys Ile Arg Ser Ala Gln Gly Arg Leu Lys Ala 225 230 235 240 Phe Ser Thr Cys Ala Ser His Ile Thr Val Val Thr Met Phe Cys Gly 245 250 255 Pro Ala Met Phe Met Tyr Met Asn Pro Gly Ala Asn Ala Ser Pro Glu 260 265 270 Arg Asp Lys Lys Leu Ala Leu Phe Tyr Asn Ile Ile Ser Ala Phe Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Arg Ala Phe 290 295 300 Leu Lys Leu Thr Gly Ser Arg Lys Ala Ser Glu Xaa 305 310 315

<210> 2801

Page 3112

069269_0225_SL.TXT <211> 933 <212> DNA <213> Felis catus <400> 2801

ggccctgccc cagcctgtca ccttgaggaa agccctctgt atgtccttgt tccggaggct 60 atagatgatg gggttgagga aagcagagat aacattgtag aacagggcca acttcttgtc 120 ctcttccagg gaagcctcag agccaggctt catgtacatg accatggctg gcacacagaa 180 catagtgacc acagtgatgt gggaggcaca agtggagaag gccttcagtc gcccctgggc 240 tgaacggatc ctcaagatgg caatgaagat gttggcataa atgacaagaa tgagggagag 300 tgggaccagg atgacagtaa agccaagaat gaagtctact cggtcattga ctgaggtgtc 360 tgcgcaagcc agctttaaga ctgcaggaac ttcacagaag aagtggttga tcttgttgga 420 gccacagtat ggcagacgca tggcaaaaac agtgtagata agagcagaaa tgacacccca 480 gagtccacag aaaataacca ttactccaca taaccatggg ctcatgatga ccttgtacct 540 gagtgggtgg cagatggcca catacctgtc tatagacata atggcaaaga gccacgactc 600 catgatgcct aacaccaaga aaatgtacat ttgggccaca cagctggcaa aagagatggt 660 cttcttctgg ctggctagat gtgccaacat ctgaggcaca gttgtagtgg tatagcccac 720 atccaatatg gaaaggatgc caataaagaa gtacatgggt gtgtggaggt gtgaatccag 780 gcagatgagg atggtgatta agccatttcc cagaataatc agcaggtagg tgatcaggaa 840 ggctgagaag agcagaggag tggtgctggg gttgaaggag aagcccagaa ggatgaattc 900 agccacaaag gactggttag tctcctgcat cat 933

<210> 2802 <211> 311 <212> PRT <213> Felis catus <400> 2802

Met Met Gln Glu Thr Asn Gln Ser Phe Val Ala Glu Phe Ile Leu Leu 1 5 10 15 Gly Phe Ser Phe Asn Pro Ser Thr Thr Pro Leu Leu Phe Ser Ala Phe

20 25 30

Page 3113

Leu Ile Thr 35 Tyr Leu Leu Ile 069269_0225_SL.TXT Ile Leu Gly Asn Gly Leu 40 45 Ile Thr Ile Leu Ile Cys Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Ile 50 55 60 Gly Ile Leu Ser Ile Leu Asp Val Gly Tyr Thr Thr Thr Thr Val Pro 65 70 75 80 Gln Met Leu Ala His Leu Ala Ser Gln Lys Lys Thr Ile Ser Phe Ala 85 90 95 Ser Cys Val Ala Gln Met Tyr Ile Phe Leu Val Leu Gly Ile Met Glu 100 105 110 Ser Trp Leu Phe Ala Ile Met Ser Ile Asp Arg Tyr Val Ala Ile Cys 115 120 125 His Pro Leu Arg Tyr Lys Val Ile Met Ser Pro Trp Leu Cys Gly Val 130 135 140 Met Val Ile Phe Cys Gly Leu Trp Gly Val Ile Ser Ala Leu Ile Tyr 145 150 155 160 Thr Val Phe Ala Met Arg Leu Pro Tyr Cys Gly Ser Asn Lys Ile Asn 165 170 175 His Phe Phe Cys Glu Val Pro Ala Val Leu Lys Leu Ala Cys Ala Asp 180 185 190 Thr Ser Val Asn Asp Arg Val Asp Phe Ile Leu Gly Phe Thr Val Ile 195 200 205 Leu Val Pro Leu Ser Leu Ile Leu Val Ile Tyr Ala Asn Ile Phe Ile 210 215 220 Ala Ile Leu Arg Ile Arg Ser Ala Gln Gly Arg Leu Lys Ala Phe Ser 225 230 235 240

Page 3114

Thr Cys Ala Ser His 245 Ile Thr 069269_0225_SL.TXT Val Val Thr Met Phe Cys 250 Val Pro 255 Ala Met Val Met Tyr Met Lys Pro Gly Ser Glu Ala Ser Leu Glu Glu Asp 260 265 270 Lys Lys Leu Ala Leu Phe Tyr Asn Val Ile Ser Ala Phe Leu Asn Pro 275 280 285 Ile Ile Tyr Ser Leu Arg Asn Lys Asp Ile Gln Arg Ala Phe Leu Lys 290 295 300 Val Thr Gly Trp Gly Arg Ala

305 310 <210> 2803 <211> 948 <212> DNA <213> Felis catus <400> 2803

atgcagagcc tcggcaagga gaaccacagc tttgtatctg agttcatcct ccttggcttc 60 tccagtgagt cacaggtcag aatagccctg ttctccttct tccttctcct ctacctcatc 120 attcttctgg gcaatggact catcatcacc ctgatctaca tggactcaca cctccacaca 180 cccatgtact tctttctcag catcctctcc ttggtggaca tgagctatgt cactaccacc 240 atgccccaga tgttgattaa tatggtgtgt ccaaagaaaa ccatctcctg gggagcttgt 300 gtagcccaaa tgttcatctt cttggtcctg ggcattgctg agtgtgtgct ctatgccatt 360 atggcctatg acaggtatgt ggccatttgc ttcccccttc actatccctt gctcatgggc 420 cgctccattt gtatcaagat ggtcacaggc tgttgggcca ttagcatagc tggggccctg 480 atctacactg tcttcaccat gcgtctgcct tattgtggcc cctacaagat aaaccacttc 540 ttttgtgagg tccctgctgt cctaaagttg gcctgtgcag acacatcctt caatgaccat 600 ttggacttca tcttgggttt caccctgctc ttggttccat tctccctcat cctggtctct 660 tatgtctgca tctttgcctc catcttaaga atccactcat cccacgggag gctcaagtct 720 ttctccacat gtgcctccca cattactgtg gtcattatgt tctatgggcc agccatgata 780

Page 3115

069269_0225_SL.TXT atgtacatga ggcctggctc ctggtatgac ccaaagcggg acaagaagct agctctgttc tacaatgttg tctctgcctt cctcaacccc atcatctaca gcctccggaa caaagatgta aagggggcct ttctgaatgt atttggtaac agaagggcat ctcagtga

840

900

948 <210> 2804 <211> 315 <212> PRT <213> Felis catus <400> 2804

Met Gln 1 Ser Leu Gly Lys Glu Asn His Ser Phe Val Ser Glu Phe Ile 5 10 15 Leu Leu Gly Phe Ser Ser Glu Ser Gln Val Arg Ile Ala Leu Phe Ser 20 25 30 Phe Phe Leu Leu Leu Tyr Leu Ile Ile Leu Leu Gly Asn Gly Leu Ile 35 40 45 Ile Thr Leu Ile Tyr Met Asp Ser His Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Ser Ile Leu Ser Leu Val Asp Met Ser Tyr Val Thr Thr Thr 65 70 75 80 Met Pro Gln Met Leu Ile Asn Met Val Cys Pro Lys Lys Thr Ile Ser 85 90 95 Trp Gly Ala Cys Val Ala Gln Met Phe Ile Phe Leu Val Leu Gly Ile 100 105 110 Ala Glu Cys Val Leu Tyr Ala Ile Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys Phe Pro Leu His Tyr Pro Leu Leu Met Gly Arg Ser Ile Cys 130 135 140 Ile Lys Met Val Thr Gly Cys Trp Ala Ile Ser Ile Ala Gly Ala Leu 145 150 155 160

Page 3116

069269_0225_SL.TXT

Ile Tyr Thr Val Phe Thr Met Arg Leu Pro Tyr Cys Gly Pro Tyr Lys 165 170 175 Ile Asn His Phe Phe Cys Glu Val Pro Ala Val Leu Lys Leu Ala Cys 180 185 190 Ala Asp Thr Ser Phe Asn Asp His Leu Asp Phe Ile Leu Gly Phe Thr 195 200 205 Leu Leu Leu Val Pro Phe Ser Leu Ile Leu Val Ser Tyr Val Cys Ile 210 215 220 Phe Ala Ser Ile Leu Arg Ile His Ser Ser His Gly Arg Leu Lys Ser 225 230 235 240 Phe Ser Thr Cys Ala Ser His Ile Thr Val Val Ile Met Phe Tyr Gly 245 250 255 Pro Ala Met Ile Met Tyr Met Arg Pro Gly Ser Trp Tyr Asp Pro Lys 260 265 270 Arg Asp Lys Lys Leu Ala Leu Phe Tyr Asn Val Val Ser Ala Phe Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Phe 290 295 300 Leu Asn Val Phe Gly Asn Arg Arg Ala Ser Gln

305 310 315 <210> 2805 <211> 939 <212> DNA

<213> Felis catus <400> 2805 atgcaagaac tcaaccagtc ctctgtgaca gaattcattc tattgggttt tgctcccaac cctaggacca accctctgct cttcaccttc tttctcacct tttacctgct aatcctcata agcaacagcc tcctcatcac ccttattcac caggattctc gtctccacac acccatgtac

120

180

Page 3117

069269_0225_SL.TXT

tttttcatca gtgtcctctc cacgctggac gtgtgctaca caaccactac cgtgccccag 240 atgcttgtgc atattctcag tgagaagagg accatctctt ttgctagatg tgtggcccag 300 atgtacatct tcctcctctt tggggtcact gagtcgtggc ttttctctat catgtctgtg 360 gacaggtacg tggccatctg ccatcctctc cggtataaga tcatcatgag ccattggatg 420 tgcctcctca tggtgggcat ctgtgcagcc tatggtgtgg tgggtggcct gtgctatacc 480 ttctttgcta tgaatctgcc ctactgtggc cctaatgaaa ttgaccacta cttctgtgag 540 gtccctgctg tcctaaagct ggcctgtgca gacacatccc tcaatgactt ggtggacttc 600 atcacgggct tcaatgtcat tgtggtccca ctgtccctgg ttgtcatagt ctatgccaat 660 atctttgcta ccatcatgaa gatccgctca gcccagggac gagtcaaagc cttctccacc 720 tgtgcctccc acatcactgt ggtcaccatg ttcgccattc catgcatcat tatgtacatg 780 agccctggct ctgactcttt gtcaaacaat ggcaagaaaa tggccctttt ttataacatt 840 gccacggcct tcctcaaccc tgtcatctac agtctgagga acaaggacgt gaaaaaggct 900 ttcctcaaat tgatgggatg gagcagggcc ccacagtga 939

<210> 2806 <211> 312 <212> PRT <213> Felis catus

<400> 2806 Asn Gln Ser 5 Ser Val Thr Glu Phe 10 Ile Leu Leu 15 Gly Met 1 Gln Glu Leu Phe Ala Pro Asn Pro Arg Thr Asn Pro Leu Leu Phe Thr Phe Phe Leu 20 25 30 Thr Phe Tyr Leu Leu Ile Leu Ile Ser Asn Ser Leu Leu Ile Thr Leu 35 40 45 Ile His Gln Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Ile Ser 50 55 60 Val Leu Ser Thr Leu Asp Val Cys Tyr Thr Thr Thr Thr Val Pro Gln 65 70 75 80

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069269_0225_SL.TXT

Met Leu Val His Ile Leu Ser Glu Lys Arg Thr Ile Ser Phe Ala Arg 85 90 95 Cys Val Ala Gln Met Tyr Ile Phe Leu Leu Phe Gly Val Thr Glu Ser 100 105 110 Trp Leu Phe Ser Ile Met Ser Val Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Lys Ile Ile Met Ser His Trp Met Cys Leu Leu Met 130 135 140 Val Gly Ile Cys Ala Ala Tyr Gly Val Val Gly Gly Leu Cys Tyr Thr 145 150 155 160 Phe Phe Ala Met Asn Leu Pro Tyr Cys Gly Pro Asn Glu Ile Asp His 165 170 175 Tyr Phe Cys Glu Val Pro Ala Val Leu Lys Leu Ala Cys Ala Asp Thr 180 185 190 Ser Leu Asn Asp Leu Val Asp Phe Ile Thr Gly Phe Asn Val Ile Val 195 200 205 Val Pro Leu Ser Leu Val Val Ile Val Tyr Ala Asn Ile Phe Ala Thr 210 215 220 Ile Met Lys Ile Arg Ser Ala Gln Gly Arg Val Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Ile Thr Val Val Thr Met Phe Ala Ile Pro Cys Ile 245 250 255 Ile Met Tyr Met Ser Pro Gly Ser Asp Ser Leu Ser Asn Asn Gly Lys 260 265 270 Lys Met Ala Leu Phe Tyr Asn Ile Ala Thr Ala Phe Leu Asn Pro Val 275 280 285

Page 3119

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Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Lys Ala Phe Leu Lys Leu 290 295 300

Met Gly Trp Ser Arg Ala Pro Gln

305 310 <210> 2807 <211> 842 <212> DNA <213> Felis catus <400> 2807 ccccagcctg tcactttgag gaaagctctc ttcacatctt tgttcctaag actatagatg 60 ataggattga ggaaggcaga gatgatgttg tagaatagag ccaacttctt atcttcttct 120 ggggaagatt cagaaccagg tctcatgtac ataaccatac atggtataga gaacatagtg 180 acaacagtaa tgtgggaggc acaggtggaa aaggccttga gctgcccttg ggctgagcga 240 attctcaaga tggcagcaaa aatattgata tagacaatga tgatgaggga gagtgggacc 300 aacagaagaa tgaagcccaa gatgaagtcc acctgatcat tgagagatgt gtctgcacag 360 gccaacttca agactgcagg tacttcacag aagaagtgat tgatctcatt aggaccacaa 420 tagggaagga tcatagtaga ggcagtgtat atcagggcac agctgatacc ccagaatcca 480 cagaaggcca ccattgaccc acatagcaaa gggctcataa tgactttata cctcagggga 540 tggcaaatgg ccacatacct gtcataagcc atgattgcaa aaagccaaga ctcagtgatt 600 cctagcatca ggaagatgta catctgcgcc acacatccaa tgtaggagat ggtcttctcc 660 ttgcaaacca ggtgtaccag catctggggc actgtggtgg tgacatagcc catatccata 720 atggatagga cactgaggaa aaagtacatg ggtgtgtgga ggcgggagtc catgcgtatc 780 aaggtgataa taagtccatt gcccagaaga gtgatgaggt agaggaagag gaagacactg 840 aa 842 <210> 2808 <211> 281 <212> PRT <213> Felis catus

Page 3120

069269_0225_SL.TXT

<400> 2808 Leu Phe Leu Tyr Leu Ile Thr Leu Leu Gly Asn 15 Gly Phe 1 Ser Val Phe 5 10 Leu Ile Ile Thr Leu Ile Arg Met Asp Ser Arg Leu His Thr Pro Met 20 25 30 Tyr Phe Phe Leu Ser Val Leu Ser Ile Met Asp Met Gly Tyr Val Thr 35 40 45 Thr Thr Val Pro Gln Met Leu Val His Leu Val Cys Lys Glu Lys Thr 50 55 60 Ile Ser Tyr Ile Gly Cys Val Ala Gln Met Tyr Ile Phe Leu Met Leu 65 70 75 80 Gly Ile Thr Glu Ser Trp Leu Phe Ala Ile Met Ala Tyr Asp Arg Tyr 85 90 95 Val Ala Ile Cys His Pro Leu Arg Tyr Lys Val Ile Met Ser Pro Leu 100 105 110 Leu Cys Gly Ser Met Val Ala Phe Cys Gly Phe Trp Gly Ile Ser Cys 115 120 125 Ala Leu Ile Tyr Thr Ala Ser Thr Met Ile Leu Pro Tyr Cys Gly Pro 130 135 140 Asn Glu Ile Asn His Phe Phe Cys Glu Val Pro Ala Val Leu Lys Leu 145 150 155 160 Ala Cys Ala Asp Thr Ser Leu Asn Asp Gln Val Asp Phe Ile Leu Gly 165 170 175 Phe Ile Leu Leu Leu Val Pro Leu Ser Leu Ile Ile Ile Val Tyr Ile 180 185 190 Asn Ile Phe Ala Ala Ile Leu Arg Ile Arg Ser Ala Gln Gly Gln Leu 195 200 205

Page 3121

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Lys Ala Phe Ser Thr Cys Ala Ser His Ile Thr Val Val Thr Met Phe 210 215 220 Ser Ile Pro Cys Met Val Met Tyr Met Arg Pro Gly Ser Glu Ser Ser 225 230 235 240 Pro Glu Glu Asp Lys Lys Leu Ala Leu Phe Tyr Asn Ile Ile Ser Ala 245 250 255 Phe Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Arg 260 265 270 Ala Phe Leu Lys Val Thr Gly Trp Gly 275 280

<210> 2809 <211> 954 <212> DNA <213> Felis catus <400> 2809

atggtgatcc caccctggga aaaccaaaca accatagcag aatttgtgct tcgaggattt 60 tcctccatcc gacagctaaa tattttcctc tttatgatgt ttttagtttt ctacatctta 120 atcatttctg gaaacatcct cattgttctg ctagtttttt tcagccatca cctccacacc 180 cccatgtact tcttcctggt gaacttgtcc tttctagaga tctggtatac ctccaacatc 240 gtccccaaga tgttgctgat catcatagct gagcagaaga ctatctctgt ggctgggtgc 300 ctggcacagt tctacttctt tggatccctg gctgcaacgg agtgtctctt gcttgctgtg 360 atgtcctatg accggtatct ggccatctgc caacctctcc actatcccat cctcatgact 420 ggcccccttt gcattaagct ggcttccagt tcttggctct gctgcttcct cctcacagca 480 attactatgg tcctactgtc tagactaacc ttctgtggac ccaatgaaat tgatcacttc 540 ttctgcgact tcacgcctct ggtccatctt tcctgcatgg acacttcact gaccgagacc 600 attgcttatg ccacctcttc tgcagtgact ctggttccat ttctcctcat cacagcctcc 660 tactcctgca ttcttgttgc catcctaaga attccatctg gcacagggcg gagaaaggct 720 ttctccacct gctcctccca cctcactgtg gtcacggtgt tttatgggac actgattgcc 780

Page 3122

069269_0225_SL.TXT acgtacctcg tgccttcagc caattcttca cagctcttgc gcaaaggatt ctctctgctc tataccatcc tgacacccat gttcaacccc atcatctaca gcctgagaaa cagagacatc cacgaagccc tgaagatgtg cttgagtaag aagccaagtt tcctccttgg atga

840

900

954 <210> 2810 <211> 317 <212> PRT <213> Felis catus

<400> 2810 Trp Glu Asn Gln Thr Thr Ile Ala Glu Phe Val Met Val 1 Ile Pro Pro 5 10 15 Leu Arg Gly Phe Ser Ser Ile Arg Gln Leu Asn Ile Phe Leu Phe Met 20 25 30 Met Phe Leu Val Phe Tyr Ile Leu Ile Ile Ser Gly Asn Ile Leu Ile 35 40 45 Val Leu Leu Val Phe Phe Ser His His Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Val Asn Leu Ser Phe Leu Glu Ile Trp Tyr Thr Ser Asn Ile 65 70 75 80 Val Pro Lys Met Leu Leu Ile Ile Ile Ala Glu Gln Lys Thr Ile Ser 85 90 95 Val Ala Gly Cys Leu Ala Gln Phe Tyr Phe Phe Gly Ser Leu Ala Ala 100 105 110 Thr Glu Cys Leu Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Leu Ala 115 120 125 Ile Cys Gln Pro Leu His Tyr Pro Ile Leu Met Thr Gly Pro Leu Cys 130 135 140 Ile Lys Leu Ala Ser Ser Ser Trp Leu Cys Cys Phe Leu Leu Thr Ala 145 150 155 160

Page 3123

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Ile Thr Met Val Leu Leu Ser Arg Leu Thr Phe Cys Gly Pro Asn Glu 165 170 175 Ile Asp His Phe Phe Cys Asp Phe Thr Pro Leu Val His Leu Ser Cys 180 185 190 Met Asp Thr Ser Leu Thr Glu Thr Ile Ala Tyr Ala Thr Ser Ser Ala 195 200 205 Val Thr Leu Val Pro Phe Leu Leu Ile Thr Ala Ser Tyr Ser Cys Ile 210 215 220 Leu Val Ala Ile Leu Arg Ile Pro Ser Gly Thr Gly Arg Arg Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Thr Val Phe Tyr Gly 245 250 255 Thr Leu Ile Ala Thr Tyr Leu Val Pro Ser Ala Asn Ser Ser Gln Leu 260 265 270 Leu Arg Lys Gly Phe Ser Leu Leu Tyr Thr Ile Leu Thr Pro Met Phe 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Arg Asp Ile His Glu Ala Leu 290 295 300 Lys Met Cys Leu Ser Lys Lys Pro Ser Phe Leu Leu Gly

305 310 315 <210> 2811 <211> 916 <212> DNA <213> Felis catus <400> 2811 atggaggcaa acaagacgca ggtgacggag tttgttctca caggactgac agatcgtcca gggatgcagg ttcccctgtt cctggtgttc ttggtcatct atctcaccac catggtgggc

120

Page 3124

069269_0225_SL.TXT

aacctcggac tgattttcct catctggaag gaccctcatc ttcacactcc catgtactta 180 ttccttggca gtttggcctt tgcagatgct tgttcctcat cctctgtgac tcccaggatg 240 tttgtcagca tcttacacaa aagtcaagtg atatctttga gtgcatggcc cagtattatt 300 tttttggttc cagtgccacc acagagtgtt tcctcttggt agtgatggcc tatgaccgct 360 acgcagccat atgcaacccc ttgctttatc cagtggtgat gtccaaccga ctctgtacct 420 tgttgataag tgtgtcatat gcgattggtt ttctgcatcc catcattcat gtgggattat 480 tgtttagatt aaccttctgc aggtccaata taatacctca tttctactgt gaaattttgt 540 cactatatac aatttcttgc actgacccat ctcttaatgc attggtgatt tttatttttg 600 ctgcttgtat acaagctttt acttttacga ccatcatggt gtcttatacc cgtgtcctct 660 ttgccatcct gagaaagaag tctgaaaagg gcaggagcag agccttctcc acgtgcagcg 720 cccacctgct ctctgtctct ttgttctatg gcactctctt cttcatgtat gtgcgtcctg 780 ggtctgggcc agatcaatat caggataaaa tgtattcatt gttctacacg gttataatcc 840 ccctgctaaa cccctttatt tatagcctaa gaaacaagga agttttaggt gcattgagaa 900 aagtgataaa gaaata 916

<210> 2812 <211> 305 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (305)..(305) <223> Any amino acid <400> 2812

Gly 1 Gly Lys Gln Asp Ala Gly Asp Gly Val Cys Ser His Arg Thr Asp 5 10 15 Arg Ser Ser Arg Asp Ala Gly Ser Pro Val Pro Gly Val Leu Gly His 20 25 30 Leu Ser His His His Gly Gly Gln Pro Arg Thr Asp Phe Pro His Leu 35 40 45

Page 3125

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Glu Gly 50 Pro Ser Ser Ser His Ser 55 His Val Leu Ile Pro Trp Gln 60 Phe Gly Leu Cys Arg Cys Leu Phe Leu Ile Leu Cys Asp Ser Gln Asp Val 65 70 75 80 Cys Gln His Leu Thr Gln Lys Ser Ser Asp Ile Phe Glu Cys Met Ala 85 90 95 Gln Tyr Tyr Phe Phe Gly Ser Ser Ala Thr Thr Glu Cys Phe Leu Leu 100 105 110 Val Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Asn Pro Leu Leu 115 120 125 Tyr Pro Val Val Met Ser Asn Arg Leu Cys Thr Leu Leu Ile Ser Val 130 135 140 Ser Tyr Ala Ile Gly Phe Leu His Pro Ile Ile His Val Gly Leu Leu 145 150 155 160 Phe Arg Leu Thr Phe Cys Arg Ser Asn Ile Ile Pro His Phe Tyr Cys 165 170 175 Glu Ile Leu Ser Leu Tyr Thr Ile Ser Cys Thr Asp Pro Ser Leu Asn 180 185 190 Ala Leu Val Ile Phe Ile Phe Ala Ala Cys Ile Gln Ala Phe Thr Phe 195 200 205 Thr Thr Ile Met Val Ser Tyr Thr Arg Val Leu Phe Ala Ile Leu Arg 210 215 220 Lys Lys Ser Glu Lys Gly Arg Ser Arg Ala Phe Ser Thr Cys Ser Ala 225 230 235 240 His Leu Leu Ser Val Ser Leu Phe Tyr Gly Thr Leu Phe Phe Met Tyr 245 250 255

Page 3126

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Val Arg Pro Gly Ser Gly Pro Asp Gln Tyr Gln Asp Lys Met Tyr Ser 260 265 270 Leu Phe Tyr Thr Val Ile Ile Pro Leu Leu Asn Pro Phe Ile Tyr Ser 275 280 285 Leu Arg Asn Lys Glu Val Leu Gly Ala Leu Arg Lys Val Ile Lys Lys

290 295 300

Xaa

305 <210> 2813 <211> 924 <212> DNA <213> Felis catus <400> 2813

atggcagaag aaaataagac acaggtgacg gagtttgttc tcatgggact tacagatctt 60 ccagggctgc aggtccccct gttcctggtg ttcttgatca tctatctcac caccatggtg 120 ggcaaccttg gtctggttgt tctcatctgg aaggacaccc accttcacaa ccccatgtac 180 ttattcctcg gcagtttggc ctttgcagat gcctgtactt catcctctgt aactcccagg 240 atgcttgtaa attttttatc caagaatcat gcgatatctc tttctgactg tctggctcag 300 ttttacattt ttggttccag tgccaccaca gagtgcttcc tcctggtagt gatggcctat 360 gaccgctatg tagccatttg caaccctttg ctttatccag tcatgatgtc caataacctc 420 tgtactcagt tcattggtgt ttcatatttt attggttttc tacattcagc aattcatgtg 480 ggtttgttat ttagattaac tttctgcagg tccaatgaaa tacattgttt ctactgtgaa 540 attatacaac ttttcaaaat ttcttgcact gatcctacag ttaatacact tctggtgtta 600 gtcttttcgg ccttcgtaca agccttcact tttacgacca tcatggtgtc ttatacccgt 660 gtcctctttg ccatcctgaa aaagaagtct gaaaagggca ggagcagagc cttctccacg 720 tgcagcgccc acctgctctc tgtttccttg ttctatggca ctctcttctt catgtatgtg 780 cgtcctgggt ctggctacac tgaagatcat gataaaattt attctttatt ttacacaata 840 ataattcctc tgctaaatcc ttttatttac agcttgagga acaaagaggt tataggtgcc 900

Page 3127

069269_0225_SL.TXT ttgagaagaa taatgaagaa ataa

924 <210> 2814 <211> 307 <212> PRT <213> Felis catus

<400> 2814 Met 1 Ala Glu Glu Asn 5 Lys Thr Gln Val Thr Glu Phe Val Leu Met Gly 10 15 Leu Thr Asp Leu Pro Gly Leu Gln Val Pro Leu Phe Leu Val Phe Leu 20 25 30 Ile Ile Tyr Leu Thr Thr Met Val Gly Asn Leu Gly Leu Val Val Leu 35 40 45 Ile Trp Lys Asp Thr His Leu His Asn Pro Met Tyr Leu Phe Leu Gly 50 55 60 Ser Leu Ala Phe Ala Asp Ala Cys Thr Ser Ser Ser Val Thr Pro Arg 65 70 75 80 Met Leu Val Asn Phe Leu Ser Lys Asn His Ala Ile Ser Leu Ser Asp 85 90 95 Cys Leu Ala Gln Phe Tyr Ile Phe Gly Ser Ser Ala Thr Thr Glu Cys 100 105 110 Phe Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Pro Val Met Met Ser Asn Asn Leu Cys Thr Gln Phe 130 135 140 Ile Gly Val Ser Tyr Phe Ile Gly Phe Leu His Ser Ala Ile His Val 145 150 155 160 Gly Leu Leu Phe Arg Leu Thr Phe Cys Arg Ser Asn Glu Ile His Cys 165 170 175

Page 3128

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Phe Tyr Cys Glu Ile Ile Gln 180 Leu Phe Lys Ile Ser Cys Thr Asp Pro 185 190 Thr Val Asn Thr Leu Leu Val Leu Val Phe Ser Ala Phe Val Gln Ala 195 200 205 Phe Thr Phe Thr Thr Ile Met Val Ser Tyr Thr Arg Val Leu Phe Ala 210 215 220 Ile Leu Lys Lys Lys Ser Glu Lys Gly Arg Ser Arg Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Leu Ser Val Ser Leu Phe Tyr Gly Thr Leu Phe 245 250 255 Phe Met Tyr Val Arg Pro Gly Ser Gly Tyr Thr Glu Asp His Asp Lys 260 265 270 Ile Tyr Ser Leu Phe Tyr Thr Ile Ile Ile Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Gly Ala Leu Arg Arg Ile 290 295 300

Met Lys Lys 305 <210> 2815 <211> 981 <212> DNA <213> Felis catus <400> 2815 atgactctgt ttttcactta ttcttccatt tcagtgatca acttgagtga gtctgatgga aacaaaacac aggtgatgga gtttgttctc atgggactta cagatcttcc agggctgcag atccccctgt tcctggtgtt cttggtcatc tacctcacta ccatggtggg caacctcgga ctgatttttc tcatctggaa ggacccccat cttcataccc ccatgtactt actccttggc

120

180

240

Page 3129

069269_0225_SL.TXT

agtttggcct ttgcagatgc ttgttcctct acctctgtga ctcccaagat gctgatgaat 300 tttttatcca acaatcactt gatatccctg gttgaatgca tcacccaatt ttatattttt 360 gcttccagtg caaacactga atgtttcctt ctggtagtga tggcctatga tcgctatgta 420 gctatatgta atcctttgct ttatccagtg gtgatgtcca atatcttttg cattcggtta 480 ttaggtgttt catatattat agggtttctt catcctatga tgcacaccag tttgttattt 540 agattaactt tctgcaagtc caatgtaata cattatttct actgtgaaat tttacaactg 600 tttaagattt cctgtactga ccctagagtt aatatgctct taatatttat attttcagtc 660 tttatacaat ctttcacctt tatgactatt atcatctctt actcccatgt cctctttgcc 720 atcctgaaaa agaggtctga aaagggcagg agcaaggcct tttccacatg cagtgcccac 780 ttgctctctg tttctttgtt ctatggcact ctcttcttca tgtatgtgcg tcctgggtct 840 ggcccagctg aaaatcaaga taaaatgtat tctgtatttt acacaatcat aattcccctg 900 ctaaatcctt ttatttacag tttgagaaac aaagaggtta taaatgcctt gaggagaata 960 ataaaatata aatagttctt a 981 <210> 2816 <211> 324 <212> PRT <213> Felis catus <400> 2816 Met Thr Leu 1 Phe Phe Thr Tyr Ser 5 Ser Ile Ser 10 Val Ile Asn Leu Ser 15 Glu Ser Asp Gly Asn Lys Thr Gln 20 Val Met Glu 25 Phe Val Leu 30 Met Gly Leu Thr Asp 35 Leu Pro Gly Leu Gln 40 Ile Pro Leu Phe Leu Val 45 Phe Leu Val Ile Tyr 50 Leu Thr Thr Met Val 55 Gly Asn Leu Gly Leu Ile 60 Phe Leu Ile Trp Lys 65 Asp Pro His Leu His 70 Thr Pro Met 75 Tyr Leu Leu Leu Gly 80

Page 3130

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Ser Leu Ala Phe Ala 85 Asp Ala Cys Ser Ser Thr Ser Val Thr Pro Lys 90 95 Met Leu Met Asn Phe Leu Ser Asn Asn His Leu Ile Ser Leu Val Glu 100 105 110 Cys Ile Thr Gln Phe Tyr Ile Phe Ala Ser Ser Ala Asn Thr Glu Cys 115 120 125 Phe Leu Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 130 135 140 Pro Leu Leu Tyr Pro Val Val Met Ser Asn Ile Phe Cys Ile Arg Leu 145 150 155 160 Leu Gly Val Ser Tyr Ile Ile Gly Phe Leu His Pro Met Met His Thr 165 170 175 Ser Leu Leu Phe Arg Leu Thr Phe Cys Lys Ser Asn Val Ile His Tyr 180 185 190 Phe Tyr Cys Glu Ile Leu Gln Leu Phe Lys Ile Ser Cys Thr Asp Pro 195 200 205 Arg Val Asn Met Leu Leu Ile Phe Ile Phe Ser Val Phe Ile Gln Ser 210 215 220 Phe Thr Phe Met Thr Ile Ile Ile Ser Tyr Ser His Val Leu Phe Ala 225 230 235 240 Ile Leu Lys Lys Arg Ser Glu Lys Gly Arg Ser Lys Ala Phe Ser Thr 245 250 255 Cys Ser Ala His Leu Leu Ser Val Ser Leu Phe Tyr Gly Thr Leu Phe 260 265 270 Phe Met Tyr Val Arg Pro Gly Ser Gly Pro Ala Glu Asn Gln Asp Lys 275 280 285

Page 3131

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Met Tyr Ser Val Phe Tyr Thr Ile Ile Ile Pro Leu Leu Asn Pro Phe 290 295 300

Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Asn Ala Leu Arg Arg Ile 305 310 315 320

Ile Lys Tyr Lys <210> 2817 <211> 928 <212> DNA <213> Felis catus <400> 2817

atgggaacta aaaatacaac agagctaaaa gagtttgttc tcatgggact tacatatcaa 60 ccagagtggc aaattccttt gttcctggta ttcctagtta tatatctcat caccattgtg 120 gcaaaccttg gtctgatttc tctcatatgc aatgagcctc agcttcacat ccccatgtac 180 tttttccttg ggaatctggc atttgtggat gtttggatat catccacggt gacccccaag 240 atgttggtca acttctttgc caagggcaag atgatctctc tctctgaatg catgatacaa 300 tttttttcct ttgtaatgag tgccaccaca gaatgttttc tgctggcaac aatggcatat 360 gatcgatatg tggccatctg caagccttta ctttatccag taattatgac cagtagacta 420 tccatgcagc tattagtttc atcatttgta ggtggacttc ttcatgccat aattcataca 480 ggctttttat tcagattaac gttctgtaat tctaacataa tacatcactt ttactgtgac 540 atcatgccat tatttaaaat ttcttgtact gatccttcta ttaatgttct gatagtattt 600 attttttctg gatcaattca gatgttcacc attctgactg ttcttgtctc ttacacatca 660 gttctcttta caatcttaaa aaagaagtct ctacaagaca taaggaaagc cttctccacc 720 tgtggaaccc atctcttatc tgtctgtttg tactatggtc ctcttctctt catgtatgtg 780 cgccctggat ctgcacaggc agatgatcaa gatatgatgg actctctatt ttacactgtc 840 ataattcctg tgttaaatcc aattatctat agcttgagaa ataagaaagt catagattca 900 ctgagaaaaa tgttaaagag gaaagctt 928

Page 3132

069269_0225_SL.TXT <210> 2818 <211> 310 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (310)..(310) <223> Any amino acid

<400> 2818 Thr Thr Glu Leu Lys Glu Phe Val Leu Met Gly Met Gly 1 Thr Lys Asn 5 10 15 Leu Thr Tyr Gln Pro Glu Trp Gln Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 Val Ile Tyr Leu Ile Thr Ile Val Ala Asn Leu Gly Leu Ile Ser Leu 35 40 45 Ile Cys Asn Glu Pro Gln Leu His Ile Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ala Phe Val Asp Val Trp Ile Ser Ser Thr Val Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Phe Ala Lys Gly Lys Met Ile Ser Leu Ser Glu 85 90 95 Cys Met Ile Gln Phe Phe Ser Phe Val Met Ser Ala Thr Thr Glu Cys 100 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Pro Val Ile Met Thr Ser Arg Leu Ser Met Gln Leu 130 135 140 Leu Val Ser Ser Phe Val Gly Gly Leu Leu His Ala Ile Ile His Thr 145 150 155 160

Page 3133

Gly Phe Leu Phe Arg 165 Leu Thr 069269_0225_SL.TXT Phe Cys Asn Ser Asn Ile 170 Ile His 175 His Phe Tyr Cys Asp Ile Met Pro Leu Phe Lys Ile Ser Cys Thr Asp Pro 180 185 190 Ser Ile Asn Val Leu Ile Val Phe Ile Phe Ser Gly Ser Ile Gln Met 195 200 205 Phe Thr Ile Leu Thr Val Leu Val Ser Tyr Thr Ser Val Leu Phe Thr 210 215 220 Ile Leu Lys Lys Lys Ser Leu Gln Asp Ile Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Thr His Leu Leu Ser Val Cys Leu Tyr Tyr Gly Pro Leu Leu 245 250 255 Phe Met Tyr Val Arg Pro Gly Ser Ala Gln Ala Asp Asp Gln Asp Met 260 265 270 Met Asp Ser Leu Phe Tyr Thr Val Ile Ile Pro Val Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Lys Val Ile Asp Ser Leu Arg Lys Met 290 295 300 Leu Lys Arg Lys Ala Xaa

305 310 <210> 2819 <211> 929 <212> DNA <213> Felis catus <400> 2819 atgggaaagg aaaatacaac attgctgaca gagttaattc tcacaggact cacatatgaa ccacagtggc aaatccccct attcctggtg ttcttggtta tctatcttct caccattgtg gggaaccttg gtctgattgc tctcatatgg aatgaacctc agcttcacat ccccatgtac

120

180

Page 3134

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tttttccttg gaagtttggc atttgtggat gcttggatat catctacagt gacccccaag 240 atgctggtca acttctttgc caagagtaag atgatctctc tctctgaatg catggtacaa 300 ttttttcctt tgcaatcagt gcaaccacag aatgttttct gctggcaaca atggcttatg 360 atcgctatgt ggccatatgc aaaccattac tttacccagt gattatgtcc aatacactat 420 gcatccggct gttagttttg tcattttcag gtggccttct tcatgccata attcacaatg 480 ctttgttatt cagattaacc ttctgtgatt ccatcatagt acatcacttt tactgtgaca 540 ttatgccatt gtttaagatt tcttgtactg acccttctat taattttctg atggtattta 600 ttttctctgg gtcaatacaa gtattcacca ttttgactgt tcttgtctct tacacactag 660 ttctttttac aatattaaaa aagaagtctc tacaaggcat aaggaaagct ttctccactt 720 gtggagccca tcttttatcc gtatctttat actatggccc ccttctcttc atgtacgtgc 780 gccctggatc tgcacaggca gatgatcaag atatgatgga ctctctattt tatactgtca 840 taattcctgt gttaaatcca attatctata gcctgagaaa taagaaagtc atagattcat 900 tgagtaaaat gttaaagaga aatgcttag 929

<210> 2820 <211> 213 <212> PRT <213> Felis catus <400> 2820

Met His Gly Thr Ile Phe Ser Phe Ala Ile Ser Ala Thr Thr Glu Cys 1 5 10 15 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 20 25 30 Pro Leu Leu Tyr Pro Val Ile Met Ser Asn Thr Leu Cys Ile Arg Leu 35 40 45 Leu Val Leu Ser Phe Ser Gly Gly Leu Leu His Ala Ile Ile His Asn 50 55 60 Ala Leu Leu Phe Arg Leu Thr Phe Cys Asp Ser Ile Ile Val His His 65 70 75 80

Page 3135

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Phe Tyr Cys Asp Ile Met Pro Leu Phe Lys Ile Ser Cys Thr Asp Pro 85 90 95 Ser Ile Asn Phe Leu Met Val Phe Ile Phe Ser Gly Ser Ile Gln Val 100 105 110 Phe Thr Ile Leu Thr Val Leu Val Ser Tyr Thr Leu Val Leu Phe Thr 115 120 125 Ile Leu Lys Lys Lys Ser Leu Gln Gly Ile Arg Lys Ala Phe Ser Thr 130 135 140 Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr Tyr Gly Pro Leu Leu 145 150 155 160 Phe Met Tyr Val Arg Pro Gly Ser Ala Gln Ala Asp Asp Gln Asp Met 165 170 175 Met Asp Ser Leu Phe Tyr Thr Val Ile Ile Pro Val Leu Asn Pro Ile 180 185 190 Ile Tyr Ser Leu Arg Asn Lys Lys Val Ile Asp Ser Leu Ser Lys Met 195 200 205 Leu Lys Arg Asn Ala

210 <210> 2821 <211> 930 <212> DNA <213> Felis <400> 2821 atggaaaaag ccacagtggc gggaaccttg tttttccttg atgctggtca catus ataatgcaac aaatccccct gtctgattgc gaagtttggc acttctttgc actactgaca attcctggtg cctcatatgg atttgtggat caagagcaaa gagttaattc ttcttggtta aatgaacctc gcttgggtat atgatatctc tcacaggact tctatcttct agcttcatat catccacagt ttcctgaatg cacatatgaa caccattatg cccgatgtac gacccccaag catgatacag

120

180

240

300

Page 3136

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tttttttcct tggcaatcag tataaccacg gaatgttttc tgctggcaac aatggcttat 360 gatcgatatg tggccatatg caaaccatta ctttatccag tgattatgtc caatacacta 420 tgcatccagc tgttagtttt gtcattttca ggtggccttc ttcatgccat aattcacaat 480 gctttgttat tcagattaac cttctgcaat tccatcatag tacatcactt ttactgtgac 540 attatgccat tgtttaagat ttcttgtact gacccttcta ttaattttct gatagtattt 600 atttttgctg ggtcaataca gatgttcacc attctgatag ttcttgtctc ctatacacta 660 gttctctttt caatcttaaa aaagaagtca ctacaaggca taagaaaagc cttctccacc 720 tgtggagccc atctcttatc tgtctgtttg tactatggcc ctcttgtctt aatgtatatg 780 cgccctgtat ctgcacaatc agatgatcaa gatatgatgg actctctatt ttatactatc 840 ataattcctt tattaaatcc aattatctac agcttgagaa ataagaaagt catagattca 900 tttggaaaaa tattaaagag aatttcttag 930

<210> 2822 <211> 309 <212> PRT <213> Felis catus

<400> 2822 Asn Ala 5 Thr Leu Leu Thr Glu Leu Ile Leu Thr Gly Met Glu 1 Lys Asp 10 15 Leu Thr Tyr Glu Pro Gln Trp Gln Ile Pro Leu Phe Leu Val Phe Leu 20 25 30 Val Ile Tyr Leu Leu Thr Ile Met Gly Asn Leu Gly Leu Ile Ala Leu 35 40 45 Ile Trp Asn Glu Pro Gln Leu His Ile Pro Met Tyr Phe Phe Leu Gly 50 55 60 Ser Leu Ala Phe Val Asp Ala Trp Val Ser Ser Thr Val Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Phe Ala Lys Ser Lys Met Ile Ser Leu Pro Glu 85 90 95

Page 3137

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Cys Met Ile Gln 100 Phe Phe Ser Leu Ala Ile Ser Ile Thr Thr Glu Cys 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Pro Val Ile Met Ser Asn Thr Leu Cys Ile Gln Leu 130 135 140 Leu Val Leu Ser Phe Ser Gly Gly Leu Leu His Ala Ile Ile His Asn 145 150 155 160 Ala Leu Leu Phe Arg Leu Thr Phe Cys Asn Ser Ile Ile Val His His 165 170 175 Phe Tyr Cys Asp Ile Met Pro Leu Phe Lys Ile Ser Cys Thr Asp Pro 180 185 190 Ser Ile Asn Phe Leu Ile Val Phe Ile Phe Ala Gly Ser Ile Gln Met 195 200 205 Phe Thr Ile Leu Ile Val Leu Val Ser Tyr Thr Leu Val Leu Phe Ser 210 215 220 Ile Leu Lys Lys Lys Ser Leu Gln Gly Ile Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ala His Leu Leu Ser Val Cys Leu Tyr Tyr Gly Pro Leu Val 245 250 255 Leu Met Tyr Met Arg Pro Val Ser Ala Gln Ser Asp Asp Gln Asp Met 260 265 270 Met Asp Ser Leu Phe Tyr Thr Ile Ile Ile Pro Leu Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Lys Val Ile Asp Ser Phe Gly Lys Ile 290 295 300

Page 3138

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Leu Lys Arg Ile Ser 305 <210> 2823 <211> 930 <212> DNA <213> Felis catus <400> 2823

atggatacta agaatgcaac aatgttgaca aaatttgttc tcacaggaat cacatatcaa 60 ccagagtggc aaatccctct gtttctgatg ttcttggtga tatacatcat cactattgtg 120 ggaaaccttg gactaactgc tctcatctac aatgaccccc accttcacat tcccatgtac 180 tttctccttg ggagtttagc ctttgtggat gcttggatat catctacagt gaccccaaag 240 atgctggtca acttcctagc caagagtaag atgataactc tttctgaatg tgtgacacaa 300 ttgttttcct ttgcatttgg tgccaccaca gaatgttttc tcttggcaac aatggcatat 360 gatcgctatg tagccatatg caaaccatta ctttatccag taattatgac ctatagactt 420 tgcatctggc tgttagtttc atcatttgta agtggattta ttcattctgt agttcatata 480 ggttttttat ttagattaac cttttgtaat tctaacataa tatatcattt ttactgtgac 540 atcatgccat tgtttaagat ttcctgtact gatccttcaa ttaatattct gatgattttt 600 attttctctg ggtcaataca ggtatttacc attctgattg ttctggtttc ttatacactt 660 attcttttca tgatcttaaa aaagaagtct ctgcaaggca taaaaaaagc cttctccacc 720 tgtggagccc atctcttatc tgtttcttta tactatggcc ctcttctatt catgtatgtg 780 cacccaggat ccgcacaatc acctgatcag gatatgatgg actctctatt ttacactgtc 840 ataattcctt tgttaaatcc aattatctat agtctaagaa ataaaaaagt catagattca 900 ctaagaaaaa tgttaaaaag aaatgtttag 930

<210> 2824 <211> 309 <212> PRT <213> Felis catus <400> 2824

Met Asp Thr Lys Asn Ala Thr Met Leu Thr Lys Phe Val Leu Thr Gly Page 3139

069269_0225_SL.TXT

1 5 10 15 Ile Thr Tyr Gln Pro Glu Trp Gln Ile Pro Leu Phe Leu Met Phe Leu 20 25 30 Val Ile Tyr Ile Ile Thr Ile Val Gly Asn Leu Gly Leu Thr Ala Leu 35 40 45 Ile Tyr Asn Asp Pro His Leu His Ile Pro Met Tyr Phe Leu Leu Gly 50 55 60 Ser Leu Ala Phe Val Asp Ala Trp Ile Ser Ser Thr Val Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Ala Lys Ser Lys Met Ile Thr Leu Ser Glu 85 90 95 Cys Val Thr Gln Leu Phe Ser Phe Ala Phe Gly Ala Thr Thr Glu Cys 100 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Pro Val Ile Met Thr Tyr Arg Leu Cys Ile Trp Leu 130 135 140 Leu Val Ser Ser Phe Val Ser Gly Phe Ile His Ser Val Val His Ile 145 150 155 160 Gly Phe Leu Phe Arg Leu Thr Phe Cys Asn Ser Asn Ile Ile Tyr His 165 170 175 Phe Tyr Cys Asp Ile Met Pro Leu Phe Lys Ile Ser Cys Thr Asp Pro 180 185 190 Ser Ile Asn Ile Leu Met Ile Phe Ile Phe Ser Gly Ser Ile Gln Val 195 200 205 Phe Thr Ile Leu Ile Val Leu Val Ser Tyr Thr Leu Ile Leu Phe Met

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210 215 220

Ile 225 Leu Lys Lys Lys Ser 230 Leu Gln Gly Ile Lys 235 Lys Ala Phe Ser Thr 240 Cys Gly Ala His Leu Leu Ser Val Ser Leu Tyr Tyr Gly Pro Leu Leu 245 250 255 Phe Met Tyr Val His Pro Gly Ser Ala Gln Ser Pro Asp Gln Asp Met 260 265 270 Met Asp Ser Leu Phe Tyr Thr Val Ile Ile Pro Leu Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Lys Val Ile Asp Ser Leu Arg Lys Met

290 295 300

Leu Lys Arg Asn Val 305 <210> 2825 <211> 930 <212> DNA <213> Felis catus <400> 2825

atggctaagg aaaataactc tttgacaact gagtttatcc tcataggatt tacagatcat 60 ccagtgctga atattctcct gtttttggtg ttctttgcca tctatctaat caccatggtg 120 ggaaatcttg gcctggtggc actgatttct atggagcatc gtcttcacac accaatgtac 180 atctttctgg gcaacttggc tctaatggat tcctgttgtt cctgtgccat catccccaag 240 atgttagaga acttcttttc tgagggaaaa atgatttccc tttatgaatg catggcacaa 300 ttttattttc tctgccttgc tgaaactgca gactgctttc ttctggcagc aatggcttat 360 gattgctatg tggccatttg cagcccacta cagtaccata ccatgatgtc aaagaaactc 420 tgcattcaga tgacaatagg gaccttcata gctagtaacc tgcattccat gatccatgta 480 gggcttctgt taaggttaac tttctgcagg tctaatcaaa ttgaccactt tttttgtgat 540 attcttccac tctatagact ctcctgtact gacccttata tcaacgaact aatgatctat 600

Page 3141

069269_0225_SL.TXT

attttttcaa tgccaattca aatcttcacc attgccactg tcttgttctc ttatatttgc 660 atccttttca caatttttaa aatgacatca aaagaggggc gaggtaaagc cttttctacc 720 tgtgcatccc actttctatc tgtctcaata ttctacattt gtcttctcat gtatattaga 780 ccatttgaag aaggggataa agacatacca gtggcaattt tttatacaat tgtaattcct 840 ttattaaatc cttttattta tagcttaaga aataaggaag tgataaatgg tcttaaaaaa 900 tgtatgaaga attataatat tgttaaataa 930

<210> 2826 <211> 309 <212> PRT <213> Felis catus <400> 2826

Met Ala Lys Glu Asn Asn Ser Leu Thr Thr Glu Phe Ile Leu Ile Gly 1 5 10 15 Phe Thr Asp His Pro Val Leu Asn Ile Leu Leu Phe Leu Val Phe Phe 20 25 30 Ala Ile Tyr Leu Ile Thr Met Val Gly Asn Leu Gly Leu Val Ala Leu 35 40 45 Ile Ser Met Glu His Arg Leu His Thr Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ala Leu Met Asp Ser Cys Cys Ser Cys Ala Ile Ile Pro Lys 65 70 75 80 Met Leu Glu Asn Phe Phe Ser Glu Gly Lys Met Ile Ser Leu Tyr Glu 85 90 95 Cys Met Ala Gln Phe Tyr Phe Leu Cys Leu Ala Glu Thr Ala Asp Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Cys Tyr Val Ala Ile Cys Ser 115 120 125

Page 3142

Pro Leu 130 Gln Tyr His Thr Met 135 069269_0225_SL.TXT Ile Gln Met Met Ser Lys Lys Leu Cys 140 Thr Ile Gly Thr Phe Ile Ala Ser Asn Leu His Ser Met Ile His Val 145 150 155 160 Gly Leu Leu Leu Arg Leu Thr Phe Cys Arg Ser Asn Gln Ile Asp His 165 170 175 Phe Phe Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Thr Asp Pro 180 185 190 Tyr Ile Asn Glu Leu Met Ile Tyr Ile Phe Ser Met Pro Ile Gln Ile 195 200 205 Phe Thr Ile Ala Thr Val Leu Phe Ser Tyr Ile Cys Ile Leu Phe Thr 210 215 220 Ile Phe Lys Met Thr Ser Lys Glu Gly Arg Gly Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Leu Ser Val Ser Ile Phe Tyr Ile Cys Leu Leu 245 250 255 Met Tyr Ile Arg Pro Phe Glu Glu Gly Asp Lys Asp Ile Pro Val Ala 260 265 270 Ile Phe Tyr Thr Ile Val Ile Pro Leu Leu Asn Pro Phe Ile Tyr Ser 275 280 285 Leu Arg Asn Lys Glu Val Ile Asn Gly Leu Lys Lys Cys Met Lys Asn 290 295 300 Tyr Asn Ile Val Lys

<210> 2827 <211> 930 <212> DNA <213> Felis catus

305

Page 3143

069269_0225_SL.TXT <400> 2827 atgattgagg ataaccactc cttgacaact gagtttatcc tcataggatt tacagattac 60 ccagaattga agagcctact ctttgtggtg tttcttacta tctatctgat cactatggtg 120 gggaaccttg gcctggtggc attgattttt acagagtgtc gtcttcacac accaatgtac 180 atctttctgg gcaacctagc tctaatggat tcctgttgtt cttgtgccat taccccaaag 240 atgttagaga acttcttttc taaggacaga atgatttccc tttatgaatg catggcacaa 300 ttttattttc tctgccttgc tgaaactgca gactgctttc ttctggcagc aatggcttat 360 gatcgctatg tggccatttg cagcccacta cagtaccaca ccatgatgtc aaagaaactc 420 tgcattcaga tgaccacagg ggcctacata gctggaaact tgcattctgt gattcatata 480 gggtttctct ttaggttaac tttctgtggg tctcatcaaa ttaatcactt tttttgtgat 540 gttcttccat tatacagact ctcttgtgtt gacccttcta tcaatgaatt gatgatattt 600 atcttttcag ggtcaattca agtcttctct attatcgtag ttctaatctc ttatctctgc 660 atcctcttca cgattttcaa aatgaagtcc aaagaaggaa gaggcaaagc tttatctact 720 tgtgcatccc actttctctc tgtctcaata ttctatggtt ctcttctttt tgtgtacatt 780 agaccaaatt cagttaaaga agaggataaa gatatacctg ttgctatttt ttatactcta 840 gtaattcctt tattaaaccc ctttatctat agtctaagaa ataaggaagt attaaatgtt 900 atgaaaaaaa ttatgaagaa agttttataa 930 <210> 2828 <211> 309 <212> PRT <213> Felis catus <400> 2828

Met 1 Ile Glu Asp Asn His Ser Leu Thr Thr Glu Phe Ile Leu Ile Gly 5 10 15 Phe Thr Asp Tyr Pro Glu Leu Lys Ser Leu Leu Phe Val Val Phe Leu 20 25 30 Thr Ile Tyr Leu Ile Thr Met Val Gly Asn Leu Gly Leu Val Ala Leu 35 40 45

Page 3144

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Ile Phe 50 Thr Glu Cys Arg Leu His 55 Thr Pro Met Tyr Ile Phe Leu 60 Gly Asn Leu Ala Leu Met Asp Ser Cys Cys Ser Cys Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Glu Asn Phe Phe Ser Lys Asp Arg Met Ile Ser Leu Tyr Glu 85 90 95 Cys Met Ala Gln Phe Tyr Phe Leu Cys Leu Ala Glu Thr Ala Asp Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Gln Tyr His Thr Met Met Ser Lys Lys Leu Cys Ile Gln Met 130 135 140 Thr Thr Gly Ala Tyr Ile Ala Gly Asn Leu His Ser Val Ile His Ile 145 150 155 160 Gly Phe Leu Phe Arg Leu Thr Phe Cys Gly Ser His Gln Ile Asn His 165 170 175 Phe Phe Cys Asp Val Leu Pro Leu Tyr Arg Leu Ser Cys Val Asp Pro 180 185 190 Ser Ile Asn Glu Leu Met Ile Phe Ile Phe Ser Gly Ser Ile Gln Val 195 200 205 Phe Ser Ile Ile Val Val Leu Ile Ser Tyr Leu Cys Ile Leu Phe Thr 210 215 220 Ile Phe Lys Met Lys Ser Lys Glu Gly Arg Gly Lys Ala Leu Ser Thr 225 230 235 240 Cys Ala Ser His Phe Leu Ser Val Ser Ile Phe Tyr Gly Ser Leu Leu 245 250 255

Page 3145

069269_0225_SL.TXT

Phe Val Tyr Ile 260 Arg Pro Asn Ser Val 265 Lys Glu Glu Asp Lys 270 Asp Ile Pro Val Ala Ile Phe Tyr Thr Leu Val Ile Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Leu Asn Val Met Lys Lys Ile 290 295 300 Met Lys Lys Val Leu

305 <210> 2829 <211> 971 <212> DNA <213> Felis catus <400> 2829

atggctgaag aaaatcatac catgaaaagt gagtttatcc tgacaggatt tacagatcac 60 ccagaattga agacgcttct tttcttggtg ttccttgtca tctatctgat caccatggta 120 gggaaccttg gcctggtgat attgatttca aaagagcctc atcttcacat gccaatgtac 180 atctttctgg gcaacctcgc tcttgtggat tcttgctgtg cctgtgccat tactcctaag 240 atgttaggga acttcttttc tgagaacaga atgatttctc tctatgaatg catggcacaa 300 ttttattttc tttgcaccgt tgaaactgca gactgctttc ttctggcagc aatggcctat 360 gaccgctatg tggccatatg tagcccacta cagtaccaca ccatgatgtc aaagaaactc 420 tgcattcaga tgaccacagg agccttcata gctggaaatc tacattccat gattcatgta 480 gggcttctat ttaggttagc tttctgtgga tctaatcaca tcaaccactt ttactgtgat 540 attcttcctt tatacagact ctcctgtgtt gacccttatg tcaatgagct ggtactattt 600 atcttttcag ggtcaattca agtcttcacc ataagcagtg tcttaatatc ttacctgtac 660 attctcttta ctattttcaa aatgaaatcc aaagaaggaa ggaccaaagc cttttctact 720 tgtgcatccc actttttgtc tgtttcatta ttctatggat ctcttttttt catgtacatt 780 agaccaaatt tgctcgaaga gggggataaa gatataccag ctgctattct gtttacaatt 840 gtagttccct tactaaatcc ttttatttat agcctgagga ataaggaagt aataactgtc 900

Page 3146

069269_0225_SL.TXT ctgagaaaaa ttatgaagaa aaaaaaaaat ctcatgaaaa ttggaaacaa atgacatcta ctgtagctta g

960

971 <210> 2830 <211> 317 <212> PRT <213> Felis catus <400> 2830

Met Ala 1 Glu Glu Asn 5 His Thr Met Lys Ser Glu Phe Ile Leu Thr Gly 10 15 Phe Thr Asp His Pro Glu Leu Lys Thr Leu Leu Phe Leu Val Phe Leu 20 25 30 Val Ile Tyr Leu Ile Thr Met Val Gly Asn Leu Gly Leu Val Ile Leu 35 40 45 Ile Ser Lys Glu Pro His Leu His Met Pro Met Tyr Ile Phe Leu Gly 50 55 60 Asn Leu Ala Leu Val Asp Ser Cys Cys Ala Cys Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Gly Asn Phe Phe Ser Glu Asn Arg Met Ile Ser Leu Tyr Glu 85 90 95 Cys Met Ala Gln Phe Tyr Phe Leu Cys Thr Val Glu Thr Ala Asp Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Gln Tyr His Thr Met Met Ser Lys Lys Leu Cys Ile Gln Met 130 135 140 Thr Thr Gly Ala Phe Ile Ala Gly Asn Leu His Ser Met Ile His Val 145 150 155 160

Page 3147

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Gly Leu Leu Phe Arg Leu Ala Phe Cys Gly 170 Ser Asn His Ile Asn 175 His 165 Phe Tyr Cys Asp Ile Leu Pro Leu Tyr Arg Leu Ser Cys Val Asp Pro 180 185 190 Tyr Val Asn Glu Leu Val Leu Phe Ile Phe Ser Gly Ser Ile Gln Val 195 200 205 Phe Thr Ile Ser Ser Val Leu Ile Ser Tyr Leu Tyr Ile Leu Phe Thr 210 215 220 Ile Phe Lys Met Lys Ser Lys Glu Gly Arg Thr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Phe Leu Ser Val Ser Leu Phe Tyr Gly Ser Leu Phe 245 250 255 Phe Met Tyr Ile Arg Pro Asn Leu Leu Glu Glu Gly Asp Lys Asp Ile 260 265 270 Pro Ala Ala Ile Leu Phe Thr Ile Val Val Pro Leu Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Ile Thr Val Leu Arg Lys Ile 290 295 300 Met Lys Lys Lys Lys Asn Leu Met Lys Ile Gly Asn Lys 305 310 315 <210> 2831 <211> 883 <212> DNA <213> Felis catus <400> 2831 tctttatgcc ctctgtacta acactcattg ggattcctgg actacagtca gtccagtgct ggattgggat tccattctgt gtcatgtatg tcatcgctgt gactgggaat tccctaatct tgggtatcat cagatatgaa cgcagcctcc ataagcccat gtacatattt ttggccatgc

120

180

Page 3148

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tgggggccac agacattgca cttagcacct gtattcttcc caaaatgtta ggcatcttct 240 ggtttcattt gccagagatt tcctttgcag cctgcctgct acaaatgtgg cttatccatt 300 cgttccaggc aatcgaatca ggcatcctac tggcaatggc cctagatcgc tatgtggcca 360 tctgtgaccc cttgagacac accaccatct tctcccagca actcttgact cacattggag 420 ttggggtgac actccgggct gccattctta taggaccatc cattatgctc atcaaatgtc 480 gtctgaaact ctaccgaact acggtcatct ctcactctta ctgtgagcac atggccgttg 540 tgaagctagc tattgaagat gtccagatca acaagatata tggtctattt gttgccttca 600 gtatcttagg ttttgacata atcttcatca ccttgtctta tgttcaaatc tttctcactg 660 tgtttcaatt gccccagaag gaggcacgat tcaaggcctt taatacctgc attgcccaca 720 tctgtgtctt cctccagttc tacctccttg ctttcttctc tttcttcaca catcggtttg 780 gttctcacat accaccatat gttcatatcc tcctatcaaa cctttacctg ttagtcccac 840 cttttctcaa ccccattgtc tatggtgtga agaccaaaca aat 883

<210> 2832 <211> 294 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (294)..(294) <223> Any amino acid <400> 2832

Phe Met Pro Ser Val Leu Thr Leu Ile Gly Ile Pro Gly Leu Gln Ser 1 5 10 15

Val Gln Cys Trp Ile Gly Ile Pro Phe Cys Val Met Tyr Val Ile Ala 20 25 30

Val Thr Gly Asn Ser Leu Ile Leu Gly Ile Ile Arg Tyr Glu Arg Ser 35 40 45

Leu His Lys Pro Met Tyr Ile Phe Leu Ala Met Leu Gly Ala Thr Asp 50 55 60

Page 3149

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Ile Ala 65 Leu Ser Thr Cys Ile Leu Pro Lys Met Leu Gly Ile Phe Trp 80 70 75 Phe His Leu Pro Glu Ile Ser Phe Ala Ala Cys Leu Leu Gln Met Trp 85 90 95 Leu Ile His Ser Phe Gln Ala Ile Glu Ser Gly Ile Leu Leu Ala Met 100 105 110 Ala Leu Asp Arg Tyr Val Ala Ile Cys Asp Pro Leu Arg His Thr Thr 115 120 125 Ile Phe Ser Gln Gln Leu Leu Thr His Ile Gly Val Gly Val Thr Leu 130 135 140 Arg Ala Ala Ile Leu Ile Gly Pro Ser Ile Met Leu Ile Lys Cys Arg 145 150 155 160 Leu Lys Leu Tyr Arg Thr Thr Val Ile Ser His Ser Tyr Cys Glu His 165 170 175 Met Ala Val Val Lys Leu Ala Ile Glu Asp Val Gln Ile Asn Lys Ile 180 185 190 Tyr Gly Leu Phe Val Ala Phe Ser Ile Leu Gly Phe Asp Ile Ile Phe 195 200 205 Ile Thr Leu Ser Tyr Val Gln Ile Phe Leu Thr Val Phe Gln Leu Pro 210 215 220 Gln Lys Glu Ala Arg Phe Lys Ala Phe Asn Thr Cys Ile Ala His Ile 225 230 235 240 Cys Val Phe Leu Gln Phe Tyr Leu Leu Ala Phe Phe Ser Phe Phe Thr 245 250 255 His Arg Phe Gly Ser His Ile Pro Pro Tyr Val His Ile Leu Leu Ser 260 265 270

Page 3150

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Asn Leu Tyr Leu Leu Val Pro Pro Phe Leu Asn Pro Ile Val Tyr Gly 275 280 285

Val Lys Thr Lys Gln Xaa 290 <210> 2833 <211> 920 <212> DNA <213> Felis catus <400> 2833

tttccaaagg attttttcag agccctcttt atgtctctgt tcctcaggct gtagatgaag 60 gggttcagca tgggcgtgac caccgtgtac atcaccgagg ccgtggcacc cgagtaggag 120 ctctgggtag cagtggagct aaggtacaca cctaggcttg tacagtaaaa taagaagacc 180 acagaaaggt gggatgcaca ggtggaaaat gctttatact tgccctgagt tgatgagatc 240 ccacatatgg aagaaactat cttagaataa gagtaaacga tcccagcaag ggggccccca 300 cccagcaacc cagctccaaa atacatcacc atgtcattaa gaaaggtgtc agaacaggca 360 agttggacca cctgtttaat ttcacagaag aagtgaggga tttccaagtc tgtacagaag 420 gacagtcgca gcaccactga ggtttgtaac aaggaatgca ggacactcat gatccaagac 480 accagagcca gcagcccaca gagccggggg ttcatgacga ccgtgtagtg cagggggtga 540 cagatggcca aaaatcggtc ataggccatc acggtcagga tgtagttgtc caatcctgcg 600 aagagtagga aaaaatacat ctgggtgatg cagtcctcat aggttatgac tttgctctgg 660 gtctggatgt tccagagcat ctttgggacg gtggtggagg tgaagcaaat gtctacaaag 720 gacaggttgg ccaggaagaa gtacatgggc gtgtggaggt gggagtcaga gctgatggcc 780 aggatgatga gcagattccc aaacacagtg atcaggtaca tggagaggaa aagcccaaat 840 atgaggggct ggaatgctgg ttcctctgaa aatcccagaa gaagaaattc tgaaatggct 900 gtaaggttcc ttggctccat 920

<210> 2834 <211> 307 <212> PRT <213> Felis catus

Page 3151

069269_0225_SL.TXT <220>

<221> MOD_RES <222> (307)..(307) <223> Any amino acid

<400> 2834 Met 1 Glu Pro Arg Asn 5 Leu Thr Ala Ile Ser Glu Phe Leu Leu Leu Gly 10 15 Phe Ser Glu Glu Pro Ala Phe Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala 35 40 45 Ile Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Asp 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Leu Leu Phe Ala Gly Leu Asp Asn 100 105 110 Tyr Ile Leu Thr Val Met Ala Tyr Asp Arg Phe Leu Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Val Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Ala Leu Val Ser Trp Ile Met Ser Val Leu His Ser Leu Leu Gln Thr 145 150 155 160 Ser Val Val Leu Arg Leu Ser Phe Cys Thr Asp Leu Glu Ile Pro His 165 170 175

Page 3152

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Phe Phe Cys Glu Ile Lys Gln Val Val Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asp Met Val Met Tyr Phe Gly Ala Gly Leu Leu Gly Gly 195 200 205 Gly Pro Leu Ala Gly Ile Val Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Cys Gly Ile Ser Ser Thr Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Phe Leu Phe Tyr Cys Thr Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Thr Ala Thr Gln Ser Ser Tyr Ser Gly Ala 260 265 270 Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Lys Lys Ser 290 295 300 Phe Gly Xaa

305 <210> 2835 <211> 1111 <212> DNA <213> Felis <400> 2835 ttaagaggtg tataccagcc gacccacagt gtttaacatg ggtggaaggc catus atgactgact ccactaagct cttttcatgg ggtgtgatga cttaggtaga tgtttccagc tcacaccaga catttttcac tggtgtaaaa tgaagaggca aacccttttg gtccctctta ctctgtgttt cacagccacc ggggacaaag gaaactggta tttctgtcga ctcagggtgt atcttgtcct aacaagatca caatgcaggc acaacctccc agatcagagg cagtaaaagt ccactgtgat

120

180

240

300

Page 3153

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gtgggaagca cacgtagaca gggccttgcg cctcccctct gacgagcggg tcttaaagga 360 aagcaagatg acaatgtaag agcccataag aatgacaaag cagctcagtg aaatcatgcc 420 actgttagct atcacaatga gccccaccat gtatgtctct gtgcaagcca gcttcagtaa 480 agggtggaca tcacagaagt agtggtcaat caggttgggg ccacagaacg gcagttgtac 540 agtgaggatg gtctggatga aggaatgcac aaaccctcct aaccaacagg ttaccaccag 600 tatagagcag accttccggt ccatgatggt catatagcgc agaggcttac agatagccac 660 gtacctgtca taggccatca ctgtgagaat aaagatctct gtgcagccaa acagatggga 720 gaaaaagagc tggaccatac aaccaacaaa ggagatgctc ttgactttag cttgggaatc 780 aataatcagc ttgggggctg taacagagga gtagcagatg tcgacaaagg ataggaagct 840 gaggaagaag tacattggag agttgagatt gggactcctt tgaatagtca ttataatgag 900 aaaatttcca gtcatgagtg tcatgtaaaa gagtaagaac agaaagaagc atagttgctg 960 cactttctca ttttgggaaa gacccatgaa gataaattct gtaacattat tttccatgga 1020 aactaggaag ctcacaagag ggaaatacag tgtgacttta cctataggaa aaaagtatga 1080 aacacaatta gatttgggca catggtacca t 1111

<210> 2836 <211> 338 <212> PRT <213> Felis catus

<400> 2836 Met Glu Asn Asn 1 Val 5 Thr Glu Phe Ile Phe Met Gly Leu Ser Gln Asn 10 15 Glu Lys Val Gln Gln Leu Cys Phe Phe Leu Phe Leu Leu Phe Tyr Met 20 25 30 Thr Leu Met Thr Gly Asn Phe Leu Ile Ile Met Thr Ile Gln Arg Ser 35 40 45 Pro Asn Leu Asn Ser Pro Met Tyr Phe Phe Leu Ser Phe Leu Ser Phe 50 55 60 Val Asp Ile Cys Tyr Ser Ser Val Thr Ala Pro Lys Leu Ile Ile Asp Page 3154

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Ser Gln Ala Lys Val Lys Ser Ile Ser Phe Val Gly Cys Met Val Gln 85 90 95 Leu Phe Phe Ser His Leu Phe Gly Cys Thr Glu Ile Phe Ile Leu Thr 100 105 110 Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu Arg Tyr 115 120 125 Met Thr Ile Met Asp Arg Lys Val Cys Ser Ile Leu Val Val Thr Cys 130 135 140 Trp Leu Gly Gly Phe Val His Ser Phe Ile Gln Thr Ile Leu Thr Val 145 150 155 160 Gln Leu Pro Phe Cys Gly Pro Asn Leu Ile Asp His Tyr Phe Cys Asp 165 170 175 Val His Pro Leu Leu Lys Leu Ala Cys Thr Glu Thr Tyr Met Val Gly 180 185 190 Leu Ile Val Ile Ala Asn Ser Gly Met Ile Ser Leu Ser Cys Phe Val 195 200 205 Ile Leu Met Gly Ser Tyr Ile Val Ile Leu Leu Ser Phe Lys Thr Arg 210 215 220 Ser Ser Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser His Ile 225 230 235 240 Thr Val Val Ile Leu Phe Phe Val Pro Cys Leu Phe Ile Tyr Leu Arg 245 250 255 Pro Ser Thr Thr Phe Thr Glu Asp Lys Met Val Ala Val Phe Tyr Thr 260 265 270 Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Thr

Page 3155

275 069269_0225_SL.TXT 280 285 Glu Val Lys Asn Ala Met Lys Arg Leu Trp Val Gly Arg Leu Phe Asp 290 295 300 Arg Asn Lys Arg Asp Ser Gly Val Lys Leu Ser Gly Ala Gly Ile Ala 305 310 315 320 Cys Ile Val Pro Val Ser Lys Arg Val Ala Gly Asn Lys Ser Val Ile 325 330 335

Thr Ser <210> 2837 <211> 927 <212> DNA <213> Felis catus <400> 2837

atggccatta caaataatgt gactgagtta attttcactg gcctgtttca ggatccagag 60 gttcagagag catgctttgt ggtgtttctt cctgtgtacc tggccacagt ggtgggcaat 120 ggtctcattg ttctgacagt caatgtcagt aagagtctgt gttcccccat gtacttcttc 180 cttagctact tgtccctggt ggagatcgct tactcctcta ctgttgtccc taaattcatc 240 acagacttac ttgccaagat taaaaccatc tctctggagg gctgtgtggc tcagatattc 300 ttcttccact tctttggggt cactgagatc cttttgcttg tggtgatggc ctatgaccgc 360 tatgtggcca tctgcaagcc tcttcagtat atgaacatta tgagccgcca actatgtcat 420 gtactggtgg ctggctcctg gcttgggggc tttttccact ccattataca gattctcatt 480 accgtccagt tgcccttctg tggtcccaat gtgattgacc actacttctg tgatcttcag 540 ccattattca agcttgcctg cactgacacc tttgtggagg gggttattgt gttggccaac 600 agtggcttaa ttgctctgtg ctccttcctc attttggtgt cctcctatat tatcatcctt 660 gtcaacttga ggaaccattc tgcagagggg aggcgcaaag ccctctctac ctgtgcctct 720 cacatcacag tggtcctctt gttctttgga cctgccatct tcctctacat gcgaccctcc 780 tccaccttca ctgaggacaa actggtggcc gtgttctaca cagttgtcac ccccatgctg 840

Page 3156

069269_0225_SL.TXT aaccccatca tctacacact cagaaatgca gaggtgaaaa ttgccatgag gaggttgtgg ggcaaaaaga acttagggat ggaataa

900

927 <210> 2838 <211> 308 <212> PRT <213> Felis catus <400> 2838

Met Ala 1 Ile Thr Asn Asn Val Thr Glu Leu Ile Phe Thr Gly Leu Phe 5 10 15 Gln Asp Pro Glu Val Gln Arg Ala Cys Phe Val Val Phe Leu Pro Val 20 25 30 Tyr Leu Ala Thr Val Val Gly Asn Gly Leu Ile Val Leu Thr Val Asn 35 40 45 Val Ser Lys Ser Leu Cys Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu 50 55 60 Ser Leu Val Glu Ile Ala Tyr Ser Ser Thr Val Val Pro Lys Phe Ile 65 70 75 80 Thr Asp Leu Leu Ala Lys Ile Lys Thr Ile Ser Leu Glu Gly Cys Val 85 90 95 Ala Gln Ile Phe Phe Phe His Phe Phe Gly Val Thr Glu Ile Leu Leu 100 105 110 Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Gln Tyr Met Asn Ile Met Ser Arg Gln Leu Cys His Val Leu Val Ala 130 135 140 Gly Ser Trp Leu Gly Gly Phe Phe His Ser Ile Ile Gln Ile Leu Ile 145 150 155 160

Page 3157

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Thr Val Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu Gln Pro Leu Phe Lys Leu Ala Cys Thr Asp Thr Phe Val 180 185 190 Glu Gly Val Ile Val Leu Ala Asn Ser Gly Leu Ile Ala Leu Cys Ser 195 200 205 Phe Leu Ile Leu Val Ser Ser Tyr Ile Ile Ile Leu Val Asn Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 His Ile Thr Val Val Leu Leu Phe Phe Gly Pro Ala Ile Phe Leu Tyr 245 250 255 Met Arg Pro Ser Ser Thr Phe Thr Glu Asp Lys Leu Val Ala Val Phe 260 265 270 Tyr Thr Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Ile Ala Met Arg Arg Leu Trp Gly Lys Lys Asn 290 295 300 Leu Gly Met Glu

305 <210> 2839 <211> 930 <212> DNA <213> Felis catus <400> 2839 atggcgagta caaataacgt gaccaagtta attatcgtcg gtcttttcca ggatccagag gtgcagagag ggtgctttgt ggtgtttctt ctggtgtact tggccacagt ggtgggcaat ggtctcattg ttctgacagt caatgtcagt aagagtctgc gttcccccat gtacttcttc

120

180

Page 3158

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cttagctact tgtccctggt ggagatcact tactcctcca ctgttgtccc taaattcatc 240 acagacttac ttgccaagat taaaaccatc tccctggagg gctgtgtggc tcagatattc 300 ttcttccact tctttggagt tactgagatc ttcctgctga cggtaatggc ctatgaccgc 360 tacgtggcca tttgcaaacc ccttcactac acaactatca tgagccggtc tgtgtgtcgc 420 cttctggtgg ctggatcctg gctcgggggc ttttttcatt ccatggtcca gattattatc 480 actctccagt tgtctttctg tggtcccaat gtgattgacc actacttctg tgacctccat 540 ccgttattca agctttcctg cactgacact tctgtggagg gggttattgt gttggccaac 600 agtggattat tttctatctt ctccttcctc ctcctggtgt cctcctatat tgtcatcctg 660 tacaacctga ggaaccattc tgcagagggg aggcgcaaag ccctctccac ctgtgcctct 720 cacatcactg tggtcctctt gttctttgga cctgccatct tcctctacat gcggcctccc 780 tctactttca ctgaggacaa actggtggcc gtgttctaca cagttgtcac ccccatgctg 840 aaccccatca tctacacact caggaatgca gaggtgaaaa atgccatgag gaagctgtgg 900 gggaagagaa tgaattcagg gagggactaa 930

<210> 2840 <211> 309 <212> PRT <213> Felis catus <400> 2840

Met 1 Ala Ser Thr Asn Asn 5 Val Thr Lys Leu Ile Ile Val Gly Leu Phe 10 15 Gln Asp Pro Glu Val Gln Arg Gly Cys Phe Val Val Phe Leu Leu Val 20 25 30 Tyr Leu Ala Thr Val Val Gly Asn Gly Leu Ile Val Leu Thr Val Asn 35 40 45 Val Ser Lys Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu 50 55 60 Ser Leu Val Glu Ile Thr Tyr Ser Ser Thr Val Val Pro Lys Phe Ile 65 70 75 80

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Thr Asp Leu Leu Ala 85 Lys Ile Lys Thr Ile Ser Leu Glu Gly Cys Val 90 95 Ala Gln Ile Phe Phe Phe His Phe Phe Gly Val Thr Glu Ile Phe Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Ser Arg Ser Val Cys Arg Leu Leu Val Ala 130 135 140 Gly Ser Trp Leu Gly Gly Phe Phe His Ser Met Val Gln Ile Ile Ile 145 150 155 160 Thr Leu Gln Leu Ser Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu His Pro Leu Phe Lys Leu Ser Cys Thr Asp Thr Ser Val 180 185 190 Glu Gly Val Ile Val Leu Ala Asn Ser Gly Leu Phe Ser Ile Phe Ser 195 200 205 Phe Leu Leu Leu Val Ser Ser Tyr Ile Val Ile Leu Tyr Asn Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 His Ile Thr Val Val Leu Leu Phe Phe Gly Pro Ala Ile Phe Leu Tyr 245 250 255 Met Arg Pro Pro Ser Thr Phe Thr Glu Asp Lys Leu Val Ala Val Phe 260 265 270 Tyr Thr Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Thr Leu Arg 275 280 285

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Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp Gly Lys Arg Met 290 295 300

Asn Ser Gly Arg Asp

305 <210> 2841 <211> 919 <212> DNA <213> Felis catus <400> 2841 acacaatgtg actgaattca ttttcctagg actttctccc agccgggagg cgcagaaagt 60 ttgttttgtg ctatttctgc ttttgtacac agcagttgtg ctggggaact ccctcattgt 120 gctcactgtc atgaccagca gaagtcttgg ttctcccatg tacttcttcc tcagctgcct 180 ctcctttgtg gagatctgct actcctctac tacagccccc aaactcatct cagatttgct 240 ggctgaaagg aaagcaatat cactgtgggg ctgcatgaca cagcttttct ttatgcactt 300 ctttggtggt gctgagatct tcctgctcac tgtgatggcc tatgaccgct atgtggccat 360 ctgtaggccc ctcaactaca ggactatcat gaaccggcaa gtgtgtgctg tcctggtggg 420 agtagcatgg gtggggggct ttgtgcattc ctttgcccaa atcctcctgc tcttccactt 480 gcccttctgt ggccccaatg tgattgacca ctatttctgt gacctgcttc ccctgctcaa 540 acttgcctgc tctgacacct tcctcgtcgg tctgctgatt gttgccaacg gggggacctt 600 gtctgtgatc agctttggga tcatcttagc ctcctatgtg gtcattttac tccatctgag 660 gactcgaagc tctgaggggc ggagtaaggc cctctccacc tgtgggtccc acatcaccgt 720 ggttacctta ttctttgggc cctgcatctt catctatatg aggccttcca ccaccttgtc 780 tgtagacaag atggtggccg tgttctacac cgtcatcacg ccgctcctca accctgtcat 840 ctactccctg agaaatgctc aagtgaagaa ggccatgaag aaactgtgga tcaggacaat 900 gaagctagat gagaaatag 919 <210> 2842 <211> 305 <212> PRT <213> Felis catus

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<400> 2842 Glu Phe Ile Phe Leu Gly Leu Ser Pro Ser Arg Glu 15 His 1 Asn Val Thr 5 10 Ala Gln Lys Val Cys Phe Val Leu Phe Leu Leu Leu Tyr Thr Ala Val 20 25 30 Val Leu Gly Asn Ser Leu Ile Val Leu Thr Val Met Thr Ser Arg Ser 35 40 45 Leu Gly Ser Pro Met Tyr Phe Phe Leu Ser Cys Leu Ser Phe Val Glu 50 55 60 Ile Cys Tyr Ser Ser Thr Thr Ala Pro Lys Leu Ile Ser Asp Leu Leu 65 70 75 80 Ala Glu Arg Lys Ala Ile Ser Leu Trp Gly Cys Met Thr Gln Leu Phe 85 90 95 Phe Met His Phe Phe Gly Gly Ala Glu Ile Phe Leu Leu Thr Val Met 100 105 110 Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu Asn Tyr Arg Thr 115 120 125 Ile Met Asn Arg Gln Val Cys Ala Val Leu Val Gly Val Ala Trp Val 130 135 140 Gly Gly Phe Val His Ser Phe Ala Gln Ile Leu Leu Leu Phe His Leu 145 150 155 160 Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe Cys Asp Leu Leu 165 170 175 Pro Leu Leu Lys Leu Ala Cys Ser Asp Thr Phe Leu Val Gly Leu Leu 180 185 190 Ile Val Ala Asn Gly Gly Thr Leu Ser Val Ile Ser Phe Gly Ile Ile 195 200 205

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Leu Ala 210 Ser Tyr Val Val Ile 215 Leu Leu His Leu Arg 220 Thr Arg Ser Ser Glu Gly Arg Ser Lys Ala Leu Ser Thr Cys Gly Ser His Ile Thr Val 225 230 235 240 Val Thr Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr Met Arg Pro Ser 245 250 255 Thr Thr Leu Ser Val Asp Lys Met Val Ala Val Phe Tyr Thr Val Ile 260 265 270 Thr Pro Leu Leu Asn Pro Val Ile Tyr Ser Leu Arg Asn Ala Gln Val 275 280 285 Lys Lys Ala Met Lys Lys Leu Trp Ile Arg Thr Met Lys Leu Asp Glu 290 295 300

Lys

305 <210> 2843 <211> 934 <212> DNA <213> Felis catus <400> 2843

atggcaacta cgaacaatgt gactgaactc attctcttgg ggttctcccc caatcgggat 60 gtgcagaaga ccatttctgt gatgtttctc ctcatgtaca cggccattgt gctggggaac 120 ggcctcattg tggtgacaat catgggcagc aaagggctca cctcccccat gtatttcttc 180 ctcggctact tgtcctttgt ggagatctgt tactgctctg tcacagcccc caagctcatc 240 cttgactctt ttattgaaag gaaaatcatt tccctcaaag gctgcatcac acagatcttt 300 ttcctccatt tctttggtgg cactgagatc tttctcctga cagtgatggc ctatgaccgc 360 tatgtggcca tctgcaagcc cctgcactac actgtcatca tgaaccggcg tgcttgtggc 420 ctcctggtgg gggcagcttg gggtgggggc ttgctgcatt ctgtcgggca aacattcctt 480

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atttcccagc tgcccttctg tggccccaag gtccttgacc actacttctg tgatgtccac 540 cctgtgctga agctggcctg ctcagacacc ttcctcactg gtgtgctaat catcgccaat 600 ggtggctcca tttcagtgat cagcttcacg gtactgcttg cttcctacgt ggtcatcctg 660 cacgccctga gcacccagac ctcagaaggt cggcgcaaag ctctgtccac ctgtgcctct 720 catgttgcag ttgtgggcct gttcttcata ccctgttcct ttgtctacat gaggccctgt 780 gtcaccctcc ctgcagacaa gatagtcgct gtgttttaca cagtggtcac acctctctta 840 aaccccatca tttactcctt caggaatgct gaagtgaaaa atgccatgag gagactgata 900 gggaggaaag tgatctggga agagaaatag atga 934 <210> 2844 <211> 309 <212> PRT <213> Felis catus <400> 2844 Met Ala Thr Thr Asn Asn Val Thr Glu Leu Ile Leu Leu Gly Phe Ser 1 5 10 15 Pro Asn Arg Asp Val Gln Lys Thr Ile Ser Val Met Phe Leu Leu Met 20 25 30 Tyr Thr Ala Ile Val Leu Gly Asn Gly Leu Ile Val Val Thr Ile Met 35 40 45 Gly Ser Lys Gly Leu Thr Ser Pro Met Tyr Phe Phe Leu Gly Tyr Leu 50 55 60 Ser Phe Val Glu Ile Cys Tyr Cys Ser Val Thr Ala Pro Lys Leu Ile 65 70 75 80 Leu Asp Ser Phe Ile Glu Arg Lys Ile Ile Ser Leu Lys Gly Cys Ile 85 90 95 Thr Gln Ile Phe Phe Leu His Phe Phe Gly Gly Thr Glu Ile Phe Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu

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115 069269_0225_SL.TXT 120 125 His Tyr Thr Val Ile Met Asn Arg Arg Ala Cys Gly Leu Leu Val Gly 130 135 140 Ala Ala Trp Gly Gly Gly Leu Leu His Ser Val Gly Gln Thr Phe Leu 145 150 155 160 Ile Ser Gln Leu Pro Phe Cys Gly Pro Lys Val Leu Asp His Tyr Phe 165 170 175 Cys Asp Val His Pro Val Leu Lys Leu Ala Cys Ser Asp Thr Phe Leu 180 185 190 Thr Gly Val Leu Ile Ile Ala Asn Gly Gly Ser Ile Ser Val Ile Ser 195 200 205 Phe Thr Val Leu Leu Ala Ser Tyr Val Val Ile Leu His Ala Leu Ser 210 215 220 Thr Gln Thr Ser Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 His Val Ala Val Val Gly Leu Phe Phe Ile Pro Cys Ser Phe Val Tyr 245 250 255 Met Arg Pro Cys Val Thr Leu Pro Ala Asp Lys Ile Val Ala Val Phe 260 265 270 Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Ile Ile Tyr Ser Phe Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Arg Leu Ile Gly Arg Lys Val 290 295 300 Ile Trp Glu Glu Lys

305 <210> 2845

Page 3165

069269_0225_SL.TXT <211> 930 <212> DNA <213> Felis catus <400> 2845

atgggaacca agaacaacgt gactgaattt gtgttgttcg gccttttcca gagcagggag 60 atgcagtatg tgtgcttcgt ggtcttctcc ctcttccatg tactcactat cctggggaac 120 cttctggtca tcatcaccat caatgcaagc aagaccctga aggctcccat gtatttcttc 180 ctcagccacc tctcttttgc cgacatgtgc tatccatctg ctaccacacc caagatgatc 240 gcagacactt ttgtggagcg aaagaccatc tccttcaatg gctgcatgac ccagctcttt 300 tctgcccact tcttcggtgg cactgagata ttcctcctca cagccatggc ctatgaccgc 360 tatgtggcca tctgtagacc cctgcactac acaaccatca tgggtcagtg gaagtgtggc 420 ttgctggccg gggcctcctg ggtggctggc ttcctgcatt ccatcctaca gacactcctg 480 acagtccagc tgcccttttg tgggcccaat gagattgaca acttcttctg tgatgttcat 540 cccttgctga agctggcctg tgcagacacc tatgtggtgg ggctcattgt ggtggccaac 600 agtggcatga tctctttggt gtcctttatc atccttatca tctcctatgt ggtcatcttg 660 ttgaacctga gacgccagtc atctgagggc cggcgcaagg ctctgtccac atgtggctca 720 cacatcatca cggtcatttt ggtcctcgtg ccccccatgt tcatgtacat tcgtccctcc 780 accaccctgg ctgctgacaa acttgtcatc ctctttaaca tcgtcatgcc acctttgctg 840 aaccctctga tctacacgtt gaggaataat gaggtgaaaa atgccatgag gaaactgttt 900 agggtacaag ggagtacagg ggagaagtga 930

<210> 2846 <211> 309 <212> PRT <213> Felis catus <400> 2846

Met Gly Thr Lys Asn Asn Val Thr Glu Phe Val Leu Phe Gly Leu Phe 1 5 10 15 Gln Ser Arg Glu Met Gln Tyr Val Cys Phe Val Val Phe Ser Leu Phe 20 25 30

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His Val Leu 35 Thr Ile Leu Gly Asn Leu Leu Val Ile Ile Thr Ile Asn 40 45 Ala Ser Lys Thr Leu Lys Ala Pro Met Tyr Phe Phe Leu Ser His Leu 50 55 60 Ser Phe Ala Asp Met Cys Tyr Pro Ser Ala Thr Thr Pro Lys Met Ile 65 70 75 80 Ala Asp Thr Phe Val Glu Arg Lys Thr Ile Ser Phe Asn Gly Cys Met 85 90 95 Thr Gln Leu Phe Ser Ala His Phe Phe Gly Gly Thr Glu Ile Phe Leu 100 105 110 Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Gly Gln Trp Lys Cys Gly Leu Leu Ala Gly 130 135 140 Ala Ser Trp Val Ala Gly Phe Leu His Ser Ile Leu Gln Thr Leu Leu 145 150 155 160 Thr Val Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp Asn Phe Phe 165 170 175 Cys Asp Val His Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr Tyr Val 180 185 190 Val Gly Leu Ile Val Val Ala Asn Ser Gly Met Ile Ser Leu Val Ser 195 200 205 Phe Ile Ile Leu Ile Ile Ser Tyr Val Val Ile Leu Leu Asn Leu Arg 210 215 220 Arg Gln Ser Ser Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240

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His Ile Ile Thr Val Ile Leu Val Leu Val Pro Pro Met Phe Met Tyr 245 250 255 Ile Arg Pro Ser Thr Thr Leu Ala Ala Asp Lys Leu Val Ile Leu Phe 260 265 270 Asn Ile Val Met Pro Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Asn Glu Val Lys Asn Ala Met Arg Lys Leu Phe Arg Val Gln Gly 290 295 300 Ser Thr Gly Glu Lys

305 <210> 2847 <211> 930 <212> DNA <213> Felis catus <400> 2847

atggcgagta caaataatgt gaccgagtta attatcgtcg gtcttttcca ggatccagaa 60 gtgcagaggg catgctttgt gatgtttctt cctgtgtacc tggcgacagt ggtgggcaat 120 ggtctcattg ttctgacagt caatgtcagt aagagtctgc gttcccccat gtacttcttc 180 cttagctact tgtccctggt ggagatcact tactcctcca ctgttgtccc taaattcatc 240 acagacttac ttgccaagat taaaaccatc tccctggagg gctgtgtggc tcagatattc 300 ttcttccact tctttggagt tactgagatc ttcctgctga cggtaatggc ctatgaccgc 360 tttgtggcca tttgcaaacc tcttcgctat accaccatca tgagccagtt tgtgtgtcgt 420 cttctggtgg ctgtttcctg gctcgggggc ataattcact ccatggtcca gatcgttgtt 480 actgttcagc tgccgttctg tggtcccaat gtgattgacc actacttctg tgacctccat 540 ccgttattca agcttgcctg cactgacact tctgtggagg gggttattgt gttggccaac 600 agtggattaa tctccgtctt ctccttcctc atcttggtgt cctcctatat tgtcatcctg 660 tacaacctga ggaaccattc tgcagagggg aggcgcaaag ccctctccac ctgtgcctct 720 cacatcacag tggtcctctt gttgtttgga cctgccatct tcctctacat gcgaccctcc 780

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069269_0225_SL.TXT tccaccttca ctgaggacaa actggtggcc gtgttctaca cagttgtcac ccccatgctg aaccccatca tctacacact cagaaatgca gaggtgaaaa atgccatgag gaagctgtgg gagaagaaag tgaactcaga agtaggataa

840

900

930 <210> 2848 <211> 309 <212> PRT <213> Felis catus <400> 2848

Met Ala 1 Ser Thr Asn Asn Val Thr Glu Leu Ile Ile Val Gly Leu Phe 5 10 15 Gln Asp Pro Glu Val Gln Arg Ala Cys Phe Val Met Phe Leu Pro Val 20 25 30 Tyr Leu Ala Thr Val Val Gly Asn Gly Leu Ile Val Leu Thr Val Asn 35 40 45 Val Ser Lys Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu 50 55 60 Ser Leu Val Glu Ile Thr Tyr Ser Ser Thr Val Val Pro Lys Phe Ile 65 70 75 80 Thr Asp Leu Leu Ala Lys Ile Lys Thr Ile Ser Leu Glu Gly Cys Val 85 90 95 Ala Gln Ile Phe Phe Phe His Phe Phe Gly Val Thr Glu Ile Phe Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Met Ser Gln Phe Val Cys Arg Leu Leu Val Ala 130 135 140 Val Ser Trp Leu Gly Gly Ile Ile His Ser Met Val Gln Ile Val Val 145 150 155 160

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Thr Val Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Leu His Pro Leu Phe Lys Leu Ala Cys Thr Asp Thr Ser Val 180 185 190 Glu Gly Val Ile Val Leu Ala Asn Ser Gly Leu Ile Ser Val Phe Ser 195 200 205 Phe Leu Ile Leu Val Ser Ser Tyr Ile Val Ile Leu Tyr Asn Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 His Ile Thr Val Val Leu Leu Leu Phe Gly Pro Ala Ile Phe Leu Tyr 245 250 255 Met Arg Pro Ser Ser Thr Phe Thr Glu Asp Lys Leu Val Ala Val Phe 260 265 270 Tyr Thr Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp Glu Lys Lys Val 290 295 300 Asn Ser Glu Val Gly

305 <210> 2849 <211> 909 <212> DNA <213> Felis catus <400> 2849 atggatagtc cacgaaacat cacggaattt ttcatgctgg gactctcgca aaactctgaa gtgcagagag ttttgtttgt gttctttttg attgtctacc ttgtctctgt tgggggcaac ctacttatca tgatcaccat tatcttcagt cccaccttgg gctcccctat gtactttttc

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069269_0225_SL.TXT ctctcatgtt tgtcctttat tgatacttgc gcagactcct tgtatgaggg gagaaccatc gttgcccatt tactgggagg aactgaaatc tacgtggcca tctgcaagcc tctgcactac ctgctggtgg gggtggcttg gctggggggc gtccttcagc tgcccttctg tgggcctaac cccttgctgg agctcgcctg caccgacaca agtggtgtga tctgcctgtt gaacttcctc cattccttga ggtgccatgg tgccgagggg cacttcactg ttgttgccct gttctttgtg tctactttgt ccgtggacaa aatagtggct aaccccctga tttatacact gagaaacgca aaaaaatga <210> 2850 <211> 302 <212> PRT <213> Felis catus tattcctcat gtatgacccc caaactcatt tcttttgagg gctgtctgat tcaattcttt attctgctca cggtcatggc ctatgaccgc acgaccacca tgaccaagca tctctgtgcc ttcctgcatt cactggttca gctcctcctg gtgatcaatc actttgtctg cgacctgtac tatgtcattg gcatcctggt ggtggccaac atgctggctg cctcctacat tgtcatcctg aggcgcaaag ccctctccac ctgtggggcc ccttgtatat ttatttacat gcggccatcg gtgttttatt gtattttgac acccatgttc gaggtgaaaa atgccatgaa aaacctatgg

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<400> 2850 Met Asp Ser Pro Arg Asn Ile Thr 1 5 Gln Asn Ser Glu Val Gln Arg Val 20 Tyr Leu Val Ser Val Gly Gly Asn 35 40 Phe Ser Pro Thr Leu Gly Ser Pro 50 55 Ser Phe Ile Asp Thr Cys Tyr Ser 65 70

Glu Phe 10 Phe Met Leu Gly Leu 15 Ser Leu 25 Phe Val Phe Phe Leu 30 Ile Val Leu Leu Ile Met Ile 45 Thr Ile Ile Met Tyr Phe Phe 60 Leu Ser Cys Leu Ser Cys Met 75 Thr Pro Lys Leu Ile 80

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Ala Asp Ser Leu Tyr 85 Glu Gly Arg Thr Ile Ser Phe Glu Gly Cys Leu 90 95 Ile Gln Phe Phe Val Ala His Leu Leu Gly Gly Thr Glu Ile Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Lys His Leu Cys Ala Leu Leu Val Gly 130 135 140 Val Ala Trp Leu Gly Gly Phe Leu His Ser Leu Val Gln Leu Leu Leu 145 150 155 160 Val Leu Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asn His Phe Val 165 170 175 Cys Asp Leu Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr Val 180 185 190 Ile Gly Ile Leu Val Val Ala Asn Ser Gly Val Ile Cys Leu Leu Asn 195 200 205 Phe Leu Met Leu Ala Ala Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220 Cys His Gly Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ala 225 230 235 240 His Phe Thr Val Val Ala Leu Phe Phe Val Pro Cys Ile Phe Ile Tyr 245 250 255 Met Arg Pro Ser Ser Thr Leu Ser Val Asp Lys Ile Val Ala Val Phe 260 265 270 Tyr Cys Ile Leu Thr Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285

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Asn Ala Glu Val Lys Asn Ala Met Lys Asn Leu Trp Lys Lys 290 295 300 <210> 2851 <211> 909 <212> DNA <213> Felis catus <400> 2851 atggaaatgc cacacaatat cacagagttt ttcatgctgg gactctcaca gaagccagag 60 atacagagag tcctctttgt ggtttttttg atcatctatg tggtcaccgt gtgtggcaac 120 atgctcattg tggtcaccat tacctccagt cccaccctgg cttcccccat gtattttttc 180 ttggccaatc tgtcctttat tgatacctgt tattcttcct ctatggcccc taaactcatt 240 gcggactcct tgtgtgaggg gagagccatc tcttttgagg gttgcatggc tcagctcttt 300 ggggcccatt tcttgggagg tgttgagatt attctgctca cggtcatggc ctatgaccgc 360 tacgtggcca tctgtaagcc tctgcactac acgaccacca tgaccaagca tctctgtgcc 420 ctgctggtgg gggtggcttg gctggggggc ttcctgcatt cactggttca gctcctcctg 480 gtccttcagc tgcccttctg tgggcctaac gtgatcaatc actttgtctg cgacctgtac 540 cccttgctgg agctcgcctg cactgacaca tatgtcattg gcatcctggt ggtggccaac 600 agtggtgtga tctgcctgtt gaacttcctc atgctggctg cctcctacat tgtcatcctg 660 cattccttga ggtgtcacgg tgccgagggg aggcgcaaag ccctctccac ctgtggggcc 720 cacttcactg ttgttgccct gttctttgtg ccttgtatat ttacttatat gcggccatcg 780 tctacttggt ccatggacaa aaacatggca gtattttatg gtattctgac acctatgctg 840 aatccactca tttacaccct gagaaatgaa gacgtaaaaa atgccatgag aaagctcttc 900 attcagtaa 909 <210> 2852 <211> 302 <212> PRT <213> Felis catus <400> 2852

Met Glu Met Pro His Asn Ile Thr Glu Phe Phe Met Leu Gly Leu Ser

Page 3173

0 6926 9_02 25_S L.TX T 1 5 10 15 Gln Lys Pro Glu Ile Gln Arg Val Leu Phe Val Val Phe Leu Ile Ile 20 25 30 Tyr Val Val Thr Val Cys Gly Asn Met Leu Ile Val Val Thr Ile Thr 35 40 45 Ser Ser Pro Thr Leu Ala Ser Pro Met Tyr Phe Phe Leu Ala Asn Leu 50 55 60 Ser Phe Ile Asp Thr Cys Tyr Ser Ser Ser Met Ala Pro Lys Leu Ile 65 70 75 80 Ala Asp Ser Leu Cys Glu Gly Arg Ala Ile Ser Phe Glu Gly Cys Met 85 90 95 Ala Gln Leu Phe Gly Ala His Phe Leu Gly Gly Val Glu Ile Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Lys His Leu Cys Ala Leu Leu Val Gly 130 135 140 Val Ala Trp Leu Gly Gly Phe Leu His Ser Leu Val Gln Leu Leu Leu 145 150 155 160 Val Leu Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asn His Phe Val 165 170 175 Cys Asp Leu Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr Val 180 185 190 Ile Gly Ile Leu Val Val Ala Asn Ser Gly Val Ile Cys Leu Leu Asn 195 200 205 Phe Leu Met Leu Ala Ala Ser Tyr Ile Val Ile Leu His Ser Leu Arg

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210 215 220

Cys 225 His Gly Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ala 230 235 240 His Phe Thr Val Val Ala Leu Phe Phe Val Pro Cys Ile Phe Thr Tyr 245 250 255 Met Arg Pro Ser Ser Thr Trp Ser Met Asp Lys Asn Met Ala Val Phe 260 265 270 Tyr Gly Ile Leu Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Glu Asp Val Lys Asn Ala Met Arg Lys Leu Phe Ile Gln

290 295 300 <210> 2853 <211> 1001 <212> DNA <213> Felis catus <400> 2853 ctagtcacat gaattgttac ccaaggttac cgtatggctc cagagtttcc tcatggcgtt ttttacctcc gaatttctga gggtgtagat taaggggttt aacataggtg ttatcatagt gtaaaacaca gccgctgttt tgtcaatggg gaaggtgatc gtgggccgca ggtacacaaa tatacagggt acaaagaaca ggacgactac agtaacatgg gaggcacagg tggagagagc cttacgctgt ccttcagggc tgtgggttct cagggagtaa aggatgagga ggtaggaggt gagaagaata gaaaaaatga gcagacacat cagcccgctg ttggcggcaa caagaagtcc atagatgtgg gtgtcagagc aggagagttt cagcagaggg aaaaggtcac agatgaaatg gtcaatgacg ttggggccac agaagggcaa ccagactata aaaagaattt gaatcagagc gtgaagaaat cccccggccc aggccgtggc caccaggagg ccacacgctc gcctgttcat tgtgatcgtg tagtgcaggg gcttgcagat ggccacgtag cggtcataag ccatgactgt gagcaggatg atctcgactc ccccaaagaa atgctctgca aagagctgag tcatgcaccc accggaggag atggttttct tttcggcgag taagtcaaat atcattttgg gagccatggc Page 3175

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069269_0225_SL.TXT agaagagcag cagctgtcta tgaaggacaa gaaagacaga aaaaaataca tgggggagcc cagggctcgg ctggtggtga ttgtcacgac aatgagtagg ttgcctgcca tggtgagaaa gtagatgact ataaacacag cgaacaagag tttctgtgcg tctgggttct gtgtcaggcc aagcaggatg aattccgtca cgttgttcat tcgcccccgt gaatctacgt cggcgtctgg acgattgatc tgtctgtaaa tagcacaggg actgcaattg t

780

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900

960

1001 <210> 2854 <211> 309 <212> PRT <213> Felis catus <400> 2854

Met 1 Asn Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr Gln Asn Pro 5 10 15 Asp Ala Gln Lys Leu Leu Phe Ala Val Phe Ile Val Ile Tyr Phe Leu 20 25 30 Thr Met Ala Gly Asn Leu Leu Ile Val Val Thr Ile Thr Thr Ser Arg 35 40 45 Ala Leu Gly Ser Pro Met Tyr Phe Phe Leu Ser Phe Leu Ser Phe Ile 50 55 60 Asp Ser Cys Cys Ser Ser Ala Met Ala Pro Lys Met Ile Phe Asp Leu 65 70 75 80 Leu Ala Glu Lys Lys Thr Ile Ser Ser Gly Gly Cys Met Thr Gln Leu 85 90 95 Phe Ala Glu His Phe Phe Gly Gly Val Glu Ile Ile Leu Leu Thr Val 100 105 110 Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Thr 115 120 125 Ile Thr Met Asn Arg Arg Ala Cys Gly Leu Leu Val Ala Thr Ala Trp

130 135 140

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Ala Gly Gly Phe 145 Leu His Ala Leu Ile Gln Ile Leu Phe Ile Val Trp 150 155 160 Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Ile Cys Asp Leu 165 170 175 Phe Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr His Ile Tyr Gly Leu 180 185 190 Leu Val Ala Ala Asn Ser Gly Leu Met Cys Leu Leu Ile Phe Ser Ile 195 200 205 Leu Leu Thr Ser Tyr Leu Leu Ile Leu Tyr Ser Leu Arg Thr His Ser 210 215 220 Pro Glu Gly Gln Arg Lys Ala Leu Ser Thr Cys Ala Ser His Val Thr 225 230 235 240 Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Val Tyr Leu Arg Pro 245 250 255 Thr Ile Thr Phe Pro Ile Asp Lys Thr Ala Ala Val Phe Tyr Thr Met 260 265 270 Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Ser Glu 275 280 285 Val Lys Asn Ala Met Arg Lys Leu Trp Ser His Thr Val Thr Leu Gly

290 295 300

Asn Asn Ser Cys Asp 305 <210> 2855 <211> 930 <212> DNA <213> Felis catus <400> 2855

Page 3177

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atggagaata aaagaaatgt gactgagttt attttaatag gtcttacaca gaaccccaag 60 atgcagaata tagtgtttct gggatttttg attctataca tggtaacact ctcaggcaac 120 ctgctcattg tggttaccat taccaccacc cagactctga actcccccat gtatttcttc 180 ctgactcatc tttccttgat agacacaatt tattcttctt cttcagctcc taagctgatt 240 gtggactccc ttcacgagaa gaaaattatc tcctttaatg ggtgtatggc tcaggtttat 300 gcagaacaca tttttggtgc tactgagatc atcctgctca cagtaatggc ctatgatcgc 360 tatgtggcca tctgcagacc tctgcactat gcgactgtca tgagccacag gctgtgcttt 420 cttctgctgg gagtggcctg gactggagga tttctccatg cgaccattca gatactcttt 480 acagtctggc tgcccttctg tggtcccaat gtcatagatc atttcatgtg tgatttgtac 540 cctttattga aacttgtctg catggacact cacacccttg gtctctttgt tgctgtcaac 600 agtgggttca tctgtctttt aaacttcctc ctcttggtgg tctcctacgt agtcattcta 660 tggtccctaa agagctatag cttggaaggg aggcgcaaag ccctttccac ctgtgtctct 720 cacatcacag tagttgtctt attttttgtg ccctgtatat ttgtgtatct gcgcccagtg 780 accactctgc ccattgataa agctgttgct atcttttata ctatggtggt tccaatgtta 840 aatcccttaa tctataccct cagaaatgct gaggtaaaaa atgctatgag gaagctctgg 900 agaaaaaaag tgacttcaga taatgattaa 930

<210> 2856 <211> 309 <212> PRT <213> Felis catus

<400> 2856 Met 1 Glu Asn Lys Arg Asn Val Thr Glu Phe Ile Leu Ile Gly Leu Thr 5 10 15 Gln Asn Pro Lys Met Gln Asn Ile Val Phe Leu Gly Phe Leu Ile Leu 20 25 30 Tyr Met Val Thr Leu Ser Gly Asn Leu Leu Ile Val Val Thr Ile Thr 35 40 45 Thr Thr Gln Thr Leu Asn Ser Pro Met Tyr Phe Phe Leu Thr His Leu Page 3178

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50 55 60

Ser 65 Leu Ile Asp Thr Ile Tyr Ser 70 Ser Ser Ser 75 Ala Pro Lys Leu Ile 80 Val Asp Ser Leu His Glu Lys Lys Ile Ile Ser Phe Asn Gly Cys Met 85 90 95 Ala Gln Val Tyr Ala Glu His Ile Phe Gly Ala Thr Glu Ile Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125 His Tyr Ala Thr Val Met Ser His Arg Leu Cys Phe Leu Leu Leu Gly 130 135 140 Val Ala Trp Thr Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe 145 150 155 160 Thr Val Trp Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met 165 170 175 Cys Asp Leu Tyr Pro Leu Leu Lys Leu Val Cys Met Asp Thr His Thr 180 185 190 Leu Gly Leu Phe Val Ala Val Asn Ser Gly Phe Ile Cys Leu Leu Asn 195 200 205 Phe Leu Leu Leu Val Val Ser Tyr Val Val Ile Leu Trp Ser Leu Lys 210 215 220 Ser Tyr Ser Leu Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Val Ser 225 230 235 240 His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Val Tyr 245 250 255 Leu Arg Pro Val Thr Thr Leu Pro Ile Asp Lys Ala Val Ala Ile Phe

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260

069269_0225_SL.TXT 265 270

Tyr Thr Met Val Val Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp Arg Lys Lys Val 290 295 300 Thr Ser Asp Asn Asp

305 <210> 2857 <211> 930 <212> DNA <213> Felis catus <400> 2857

ttatttctcc cctgaaatag ctttcctgcg gcacaattta ctaatggcat ttttcatctg 60 ggcatttctc aaagtataga ttagcgggtt tagcatggga gttataatag tgtagaacac 120 tgccactgct ttatcaatag ataaagtagc tgcaggcctc atatacacaa atatgcaggg 180 cacaaagaat aagacgacca ccgtgatgtg ggaggcacag gtggagaggg ctttgcgcct 240 tgcctccaag ctgtggttcc ttagggagcg cagaatgacc acataggaga ccatcaagag 300 gaggaagttt aacagacaga tgaatccact gttggcagca acgaagaggc ctagagtgtg 360 ggtatcagtg caggcaagat tgagcaaagg gttcagatca cacataaagt ggtctatgac 420 gttagggcca cagaagggta attggaagat gaagagtatc tgtatagttg cgtgaagaaa 480 gcctcccacc cacaccactc ccattaacag gccacacacc cgccgattca tgatggtcat 540 gtagtgcaat ggcttgcaga tggccacata gcggtcatag gccatcacag taagcaggat 600 gccttcagca cctccaaaga aatgttctcc aaatatttga gtcatgcatc cattgtatag 660 ggtagtcttc tttttatgga gggaatctat gatcagttta ggagtattaa cagaggaata 720 gcaggcatca ataaaggaga ggtaggccag gaaaaagtac atgggagacc ccaacaatgg 780 gctggcagtg atagtgacca caatgagcat attacctact acagtgatgg tgtagatgac 840 aaaaaacacg acaaatataa ttttttgcat ctttggattc tctgtgagtc ccagtagaac 900 aaactctgtc acattgttcc tcttctccat 930

Page 3180

069269_0225_SL.TXT <210> 2858 <211> 309 <212> PRT <213> Felis catus

<400> 2858 Met 1 Glu Lys Arg Asn 5 Asn Val Thr Glu Phe 10 Val Leu Leu Gly Leu 15 Thr Glu Asn Pro Lys Met Gln Lys Ile Ile Phe Val Val Phe Phe Val Ile 20 25 30 Tyr Thr Ile Thr Val Val Gly Asn Met Leu Ile Val Val Thr Ile Thr 35 40 45 Ala Ser Pro Leu Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu 50 55 60 Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Asn Thr Pro Lys Leu Ile 65 70 75 80 Ile Asp Ser Leu His Lys Lys Lys Thr Thr Leu Tyr Asn Gly Cys Met 85 90 95 Thr Gln Ile Phe Gly Glu His Phe Phe Gly Gly Ala Glu Gly Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Arg Arg Val Cys Gly Leu Leu Met Gly 130 135 140 Val Val Trp Val Gly Gly Phe Leu His Ala Thr Ile Gln Ile Leu Phe 145 150 155 160 Ile Phe Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met 165 170 175

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Cys Asp Leu Asn Pro Leu Leu Asn Leu Ala Cys Thr Asp Thr His Thr 180 185 190 Leu Gly Leu Phe Val Ala Ala Asn Ser Gly Phe Ile Cys Leu Leu Asn 195 200 205 Phe Leu Leu Leu Met Val Ser Tyr Val Val Ile Leu Arg Ser Leu Arg 210 215 220 Asn His Ser Leu Glu Ala Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser 225 230 235 240 His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Val Tyr 245 250 255 Met Arg Pro Ala Ala Thr Leu Ser Ile Asp Lys Ala Val Ala Val Phe 260 265 270 Tyr Thr Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Gln Met Lys Asn Ala Ile Ser Lys Leu Cys Arg Arg Lys Ala 290 295 300 Ile Ser Gly Glu Lys

305 <210> 2859 <211> 928 <212> DNA <213> Felis catus <400> 2859 gtcacttgtc acctaaactg aactgatgaa gaagatgaac aatgtgacag aattcatcct cctgggcttg actcaaaacg tggaacttca gaaattctcc ttttttgtgt ttttaattgt ctacttggtc actttggcgg gcaacttgct catcatgatc accatcagta ccagtagtgc cctcgaaacc cccatgtact tcttcctgtc ttacttggcc cttatagatg gctgttgttc ttcctccatg acccctaaaa tgctcgctga cactcttact gtgagaaaaa tcatctcttt

120

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240

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tacaggatgt atgactcaag tctttgctga acattttttt ggtgctgctg agattatcct 360 tctcacagta atggcctatg accgttatgt ggccatctgc aaacccttgc attacacaac 420 catcatgagt caccaggtgt gtggcctcct tgtaggagtg gcctgggctg gagcctttgt 480 ccatgcaacc attcagatcc tcttcacagt ctggctgcct ttctgtggcc ccaatgtcat 540 agatcatttc atgtgtgatt tgtacccttt attgaaactt gtctgcatgg acactcatac 600 ccttggtctc tttgttgctg ccaatagtgg gttcatctgt ttgttaaact tccttctttt 660 ggtggtttcc tatgtggtca tcttgctctc cctaaagacc tatagcttgg aggggagacg 720 caaagccctc tctacctgcg tctctcacat caccgtggtc attttcttct ttgtgccctg 780 cttatttgta tatctgcgcc cagtgatcac cttttccatt gataaagctg tggctgtgtt 840 ttataccatg ataactccta tgttaaaccc tttaatctat acgttgagaa attcagaggt 900 gaaaagtgcc ataaagaagc tccggatc 928

<210> 2860 <211> 301 <212> PRT <213> Felis catus <400> 2860

Met 1 Lys Lys Met Asn 5 Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Gln Asn Val Glu Leu Gln Lys Phe Ser Phe Phe Val Phe Leu Ile Val 20 25 30 Tyr Leu Val Thr Leu Ala Gly Asn Leu Leu Ile Met Ile Thr Ile Ser 35 40 45 Thr Ser Ser Ala Leu Glu Thr Pro Met Tyr Phe Phe Leu Ser Tyr Leu 50 55 60 Ala Leu Ile Asp Gly Cys Cys Ser Ser Ser Met Thr Pro Lys Met Leu 65 70 75 80 Ala Asp Thr Leu Thr Val Arg Lys Ile Ile Ser Phe Thr Gly Cys Met 85 90 95

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Thr Gln Val Phe 100 Ala Glu His Phe Phe Gly Ala Ala Glu Ile Ile Leu 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Ser His Gln Val Cys Gly Leu Leu Val Gly 130 135 140 Val Ala Trp Ala Gly Ala Phe Val His Ala Thr Ile Gln Ile Leu Phe 145 150 155 160 Thr Val Trp Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met 165 170 175 Cys Asp Leu Tyr Pro Leu Leu Lys Leu Val Cys Met Asp Thr His Thr 180 185 190 Leu Gly Leu Phe Val Ala Ala Asn Ser Gly Phe Ile Cys Leu Leu Asn 195 200 205 Phe Leu Leu Leu Val Val Ser Tyr Val Val Ile Leu Leu Ser Leu Lys 210 215 220 Thr Tyr Ser Leu Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Val Ser 225 230 235 240 His Ile Thr Val Val Ile Phe Phe Phe Val Pro Cys Leu Phe Val Tyr 245 250 255 Leu Arg Pro Val Ile Thr Phe Ser Ile Asp Lys Ala Val Ala Val Phe 260 265 270 Tyr Thr Met Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Val Lys Ser Ala Ile Lys Lys Leu Arg Ile 290 295 300

Page 3184

069269_0225_SL.TXT <210> 2861 <211> 932 <212> DNA <213> Felis catus <400> 2861

aagtaaatgg aaccaaagaa caatgtgact gactttgtcc tcttgggcct cacacagaat 60 ccaaaggaac agaaagtact ttttgttatg ttcttgctct tctatatttt gaccatggtg 120 ggcaacctgc tcattgtctt gactgtttct tttagtaaga ccctggactc acctatgtac 180 tttttcttgc tagcttatca tttatggatg tcatttattc ctcatctatt tctcctgaac 240 tgatttcaaa tttgttcttt ggggaaaata ccatatcctt ccatgcttgt atgacccagc 300 tatttacaga gcactttttt ggtggatcag aggtctttct tctgctggtg atggcctatg 360 accgctatgt ggccatctgt aagcccttgc attatttgat tgtcatgagg caatgggtgt 420 gtgttgtgct cctggtaggg tcctgggttg ggggttttat gcattcagta attcaactta 480 gcactattta tgggctccca ttctgcggtc ccaatgtcat tgatcatttt ttctgtgaca 540 tgtacccatt actgaaactg gtctgtactg acacccgtgt cattggcctg ttagtggcgg 600 ccaacggagg actgatctgc acaattgtgt ttgtgctctt gctcatctct tatggtgtca 660 tcttgcactc tctaaagaac cttagtccgg aagggaggcg gaaagccctc cagacctgtg 720 gttcccacat cactgtggtg gtcttcttct ttgtgccctg tattttcatg tacgtgagac 780 ctgctaagac cttccctatt gacaaatcat tgagtgtgtt ttatacagtc ataaccccca 840 tgctgaaccc cctgatctac actctgagaa attctgagat gacaaatgct atgaagaaac 900 tctggaggag aaatttcaca tattgtagta aa 932

<210> 2862 <211> 243 <212> PRT <213> Felis catus <400> 2862

Met Asp Val Ile Tyr Ser Ser Ser Ile Ser Pro Glu Leu Ile Ser Asn 1 5 10 15

Leu Phe Phe Gly Glu Asn Thr Ile Ser Phe His Ala Cys Met Thr Gln 20 25 30

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Leu Phe Thr 35 Glu His Phe Phe Gly Gly Ser Glu Val Phe Leu Leu Leu 40 45 Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr 50 55 60 Leu Ile Val Met Arg Gln Trp Val Cys Val Val Leu Leu Val Gly Ser 65 70 75 80 Trp Val Gly Gly Phe Met His Ser Val Ile Gln Leu Ser Thr Ile Tyr 85 90 95 Gly Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Phe Cys Asp 100 105 110 Met Tyr Pro Leu Leu Lys Leu Val Cys Thr Asp Thr Arg Val Ile Gly 115 120 125 Leu Leu Val Ala Ala Asn Gly Gly Leu Ile Cys Thr Ile Val Phe Val 130 135 140 Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys Asn Leu 145 150 155 160 Ser Pro Glu Gly Arg Arg Lys Ala Leu Gln Thr Cys Gly Ser His Ile 165 170 175 Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Met Tyr Val Arg 180 185 190 Pro Ala Lys Thr Phe Pro Ile Asp Lys Ser Leu Ser Val Phe Tyr Thr 195 200 205 Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Ser 210 215 220 Glu Met Thr Asn Ala Met Lys Lys Leu Trp Arg Arg Asn Phe Thr Tyr 225 230 235 240

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Cys Ser Lys <210> 2863 <211> 938 <212> DNA <213> Felis catus <400> 2863 atgcagacta gatggaaaca aggagcaatg tcacttactt tgtcctcttg ggtctcacac 60 aggatccaaa gggacagaag gtccttttgg ttatgttctt acacttctat attttgacca 120 tggtgggcaa tttgctcatt gtcatgacta taactgtcag taggaccctg gactcaccta 180 tgtacttttt tcttgctagc ttatcgttta tggatgtcat ttattcctct actatttccc 240 ctagattgat ttcagacttg ttgtttggga aaaacaccat atcctttcaa tcttgtatga 300 cccagctgtt tacagagcac ttttttggtg gatcagaggt ctttcttctg ctggtgatgg 360 cctatgaccg ctacgtggcc atctgtaagc ccttgcatta tttggttatc atgagacagt 420 gggtgtgtgt tgtgctcctg gtagggtcct gggttggagg ttttctgcat tcagccattc 480 aagttagcac tatttataga ctcccattct gtggtcccaa tgtcattgat cattttttgt 540 gtgacatgta ccccttactg aaactggtct gtactgacac ccatgttatt ggcctgttag 600 tggtggccaa cggaggactg atctgcacaa ttgtgtttgt gctcttgctc atctcttatg 660 gtgtcatctt gcactctcta aagaacctta gtccggaagg gaagcggaaa gccctccaga 720 cctgtggttc ccacatcact gtggtggtct tcttctttgt gccatgtatt ttcatgtacg 780 tgagacctgc taagaccttc cctattgaca aatcattgag tgtgttctat acagtcataa 840 cccccatgct gaaccccctg atctacactc tgagaaattc tgagatgaca aatgctatga 900 ggaagctctg gaagagaaat atatctctta gtagataa 938 <210> 2864 <211> 308 <212> PRT <213> Felis catus <400> 2864

Met Glu Thr Arg Ser Asn Val Thr Tyr Phe Val Leu Leu Gly Leu Thr Page 3187

0 6926 9_02 25_S L.TX T 1 5 10 15 Gln Asp Pro Lys Gly Gln Lys Val Leu Leu Val Met Phe Leu His Phe 20 25 30 Tyr Ile Leu Thr Met Val Gly Asn Leu Leu Ile Val Met Thr Ile Thr 35 40 45 Val Ser Arg Thr Leu Asp Ser Pro Met Tyr Phe Phe Leu Ala Ser Leu 50 55 60 Ser Phe Met Asp Val Ile Tyr Ser Ser Thr Ile Ser Pro Arg Leu Ile 65 70 75 80 Ser Asp Leu Leu Phe Gly Lys Asn Thr Ile Ser Phe Gln Ser Cys Met 85 90 95 Thr Gln Leu Phe Thr Glu His Phe Phe Gly Gly Ser Glu Val Phe Leu 100 105 110 Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Val Ile Met Arg Gln Trp Val Cys Val Val Leu Leu Val 130 135 140 Gly Ser Trp Val Gly Gly Phe Leu His Ser Ala Ile Gln Val Ser Thr 145 150 155 160 Ile Tyr Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Leu 165 170 175 Cys Asp Met Tyr Pro Leu Leu Lys Leu Val Cys Thr Asp Thr His Val 180 185 190 Ile Gly Leu Leu Val Val Ala Asn Gly Gly Leu Ile Cys Thr Ile Val 195 200 205 Phe Val Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys

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210 215 220

Asn 225 Leu Ser Pro Glu Gly Lys Arg Lys Ala Leu Gln Thr Cys Gly Ser 230 235 240 His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Met Tyr 245 250 255 Val Arg Pro Ala Lys Thr Phe Pro Ile Asp Lys Ser Leu Ser Val Phe 260 265 270 Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Met Thr Asn Ala Met Arg Lys Leu Trp Lys Arg Asn Ile

290 295 300

Ser Leu Ser Arg 305 <210> 2865 <211> 695 <212> DNA <213> Felis catus <400> 2865

cttgggtact gcttccgttt tccgcctgcg tgacttatcc cttctagaag tctgctgttc 60 ttcctccatg acccgtaaaa tgctgcctgg cacttttgct gtaagaaaac catctctctg 120 aggaagtaca tgacttaagt ctttgctgag catccatgtg gccatctgca aaccccggta 180 ccatgacatc atgaagagtg acagggatat ggcttcctct ttcaggtggc atgtgctaga 240 gactttgtcc cagcagccat tcaggtcctc ttcacagtgt ggctgtgtgt gtgtggcccc 300 aatgtcagag accatttgtg tgtgatgtaa atccgttttt gaaagttgtc tgcatggaac 360 caatcatacc cttggtctct ttgttgctgt cgacagtggg ttcattgacc tgttaacatt 420 ttcttcttga tggtctcata ggtggtcatc ttctactatt ctctgaggac ctatatcttt 480 gaggggagac gcaaagcagt gtccaactgt gtctctcaca ccactgtggt gttcttagta 540 ttgtgtctgc atgtttatat atttgtaacc aatcaccacc ttctccactg atcaagttgt 600

Page 3189

069269_0225_SL.TXT ggctatgttg tataccacag tgactccatt gttaacttct taaacctgag caatcaggaa tctggaggta aaaaaatgcc atgaggaagt tctgg

660

695 <210> 2866 <211> 105 <212> PRT <213> Felis catus

<400> 2866 Gly Ala Thr His Thr Gln Pro His Cys Glu Glu Met Val 1 Ser Asp Ile 5 10 15 Asp Leu Asn Gly Cys Trp Asp Lys Val Ser Ser Thr Cys His Leu Lys 20 25 30 Glu Glu Ala Ile Ser Leu Ser Leu Phe Met Met Ser Trp Tyr Arg Gly 35 40 45 Leu Gln Met Ala Thr Trp Met Leu Ser Lys Asp Leu Ser His Val Leu 50 55 60 Pro Gln Arg Asp Gly Phe Leu Thr Ala Lys Val Pro Gly Ser Ile Leu 65 70 75 80 Arg Val Met Glu Glu Glu Gln Gln Thr Ser Arg Arg Asp Lys Ser Arg 85 90 95 Arg Arg Lys Thr Glu Ala Val Pro Lys 100 105

<210> 2867 <211> 924 <212> DNA <213> Felis catus <400> 2867 tttactactt gatgtgacat ttttcctcca gagcttcctc atagcattcg tcatctcaga atttctcaga gtgtagatca gggggttcag catgggggta agactgtata aaacacactc actgatttgt caatggggaa ggtcttagca ggtctcacgt acatgaaaat acatggcaca

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aagaagaaga ccaccacagt gatgtgggaa ccacaggtct ggagggcttt ccgcctccct 240 tccggactaa ggttctttag agagtgcaag atgacaccat aagagatgag caagagcaca 300 aacgcaattg tgcagatcag tccttcatcg cccaccacta acaggccaat gatatgggcg 360 tcagtacaga ccagtttcag taaggggtac atgtcacaca aaaaatgatc agtgaattgg 420 gaccacagaa tgggagccca taaatagtgc taacttgaat tactgaatgc agaaaacctc 480 caacccagga ccctaccagc agcacaacac acaccctttg cctcatgata cacaaataat 540 gcaggggttt acacatggcc acatagaggt cataaacatc accaagagaa gaatgatctc 600 tgatccacca aaaagctgct ctgtaaacag ctgggtcata cagtgttgaa atgacctggt 660 attttcccca catatcaaat ctgaaatcaa tctgagggaa atagaagagg agtaaatgac 720 atccataaaa ggtaagttag caagaaacaa gtacataggt gagttcaggg tcttactgac 780 agttacagtc gccaaaatga ggaggttgcc caccacagtg aaaatataga agagtgagaa 840 cacaaccaaa aggaccttct gttcctttgg atcctgtgtg agacccaaga ggataaaata 900 agtgacattg ctccttggtt ccat 924

<210> 2868 <211> 133 <212> PRT <213> Felis catus <400> 2868

Met Glu Pro Arg Ser Asn Val Thr Tyr Phe Ile Leu Leu Gly Leu Thr 1 5 10 15 Gln Asp Pro Lys Glu Gln Lys Val Leu Leu Val Val Phe Ser Leu Phe 20 25 30 Tyr Ile Phe Thr Val Val Gly Asn Leu Leu Ile Leu Ala Thr Val Thr 35 40 45 Val Ser Lys Thr Leu Asn Ser Pro Met Tyr Leu Phe Leu Ala Asn Leu 50 55 60 Pro Phe Met Asp Val Ile Tyr Ser Ser Ser Ile Ser Leu Arg Leu Ile 65 70 75 80

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Ser Asp Leu Ile Cys Gly Glu Asn Thr Arg Ser Phe Gln His Cys Met 85 90 95 Thr Gln Leu Phe Thr Glu Gln Leu Phe Gly Gly Ser Glu Ile Ile Leu 100 105 110 Leu Leu Val Met Phe Met Thr Ser Met Trp Pro Cys Val Asn Pro Cys 115 120 125 Ile Ile Cys Val Ser

130 <210> 2869 <211> 918 <212> DNA <213> Felis catus <400> 2869 atggaatcaa agaacaacgt aactttcttt gtcctcctgg gcctcacaca ggatggaaaa gaacagaagt ttctgtttgt tatattcttg ctcttctata ttttgacggt ggtgggcaac ctgctcattg tggtgactat agctgtcagt aagaccctgg gctcccctat gtacttgttt cttgctaact tatcctttat ggatgtcact tattcgtctt gcatttcccc cagattgatt tcggacttgt tctttgggga aaataccata tccttccaat cttgtatgac ccagctattt acagagcacc ttttcggtgg atcagaggtc attcttctgc tggtgatggc ttatgaccgc tatgtggcca tctgtaagcc cttgcgttat ttggttgtca tgaggcaaga ggtgtgtgtt gtgctgctgg tagggtcctg ggttggaggt tttctgcatt cagccattca agttagcacg atttatagtc tcccattctg tggtcccaat gtcattgatc atttcatctg tgaaatgtac cccttactga gacttgcctg tactgacaca tatgtcattg gcctgttagt ggtggccaac ggagggatga tgtgcacaat tgtgtttgtg ctcttgctca tctcttacgg tgtcatcttg cactctctaa agaaccttag tccggaaggg aggcggaaag ccctccagac ctgtggttcc cacatcactg tggtggtctt cttctttgtg ccatgtattt tcatgtacgt gagacctgct aagaccttcc ccattgacaa atcagtgagt gtgtttttta cagttataac ccctatgctg aaccccctga tctatactct gagaaattct gagatgacaa atgcgatgaa gaagctctgg Page 3192

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069269_0225_SL.TXT atgagaaatg tcgtatct

918 <210> 2870 <211> 306 <212> PRT <213> Felis catus

<400> 2870 Met 1 Glu Ser Lys Asn 5 Asn Val Thr Phe Phe Val Leu Leu Gly Leu Thr 10 15 Gln Asp Gly Lys Glu Gln Lys Phe Leu Phe Val Ile Phe Leu Leu Phe 20 25 30 Tyr Ile Leu Thr Val Val Gly Asn Leu Leu Ile Val Val Thr Ile Ala 35 40 45 Val Ser Lys Thr Leu Gly Ser Pro Met Tyr Leu Phe Leu Ala Asn Leu 50 55 60 Ser Phe Met Asp Val Thr Tyr Ser Ser Cys Ile Ser Pro Arg Leu Ile 65 70 75 80 Ser Asp Leu Phe Phe Gly Glu Asn Thr Ile Ser Phe Gln Ser Cys Met 85 90 95 Thr Gln Leu Phe Thr Glu His Leu Phe Gly Gly Ser Glu Val Ile Leu 100 105 110 Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Leu Val Val Met Arg Gln Glu Val Cys Val Val Leu Leu Val 130 135 140 Gly Ser Trp Val Gly Gly Phe Leu His Ser Ala Ile Gln Val Ser Thr 145 150 155 160 Ile Tyr Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Ile 165 170 175

Page 3193

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Cys Glu Met Tyr Pro Leu Leu 180 Arg Leu Ala Cys Thr Asp Thr Tyr Val 185 190 Ile Gly Leu Leu Val Val Ala Asn Gly Gly Met Met Cys Thr Ile Val 195 200 205 Phe Val Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys 210 215 220 Asn Leu Ser Pro Glu Gly Arg Arg Lys Ala Leu Gln Thr Cys Gly Ser 225 230 235 240 His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Met Tyr 245 250 255 Val Arg Pro Ala Lys Thr Phe Pro Ile Asp Lys Ser Val Ser Val Phe 260 265 270 Phe Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Met Thr Asn Ala Met Lys Lys Leu Trp Met Arg Asn Val 290 295 300

Val Ser 305 <210> 2871 <211> 919 <212> DNA <213> Felis catus <400> 2871 atggaacata ggtcagaaaa ctcctcattg cttggttact ggatcaatgt tattatttgt tggtgaccgt tatcttttat gactgagttt tgtgttcttg ggtggtcagt ggatgctgtg gtcctcttgg ctcatctaca ccaacactgg tattctacta ggctcactca ttgtgacaat attcccctat cagtcactcc gagcctccaa ggtgggcaac gtatttcttt aaatatgatt

120

180

240

Page 3194

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atagacttac tctgtgagaa gaaaaccatt tccttccaag cttgcatgtc ccagctcttt 300 ctagggcact tgtttggtgg tgcagagatt ttactcctgg tggccatggc ctatgaccgc 360 tatgtggcca tctgcaaacc cttgcattat ttgaccatca tgaatcaacg ggtgtgtgtt 420 ttgttgctgc tgctggcctg ggttggaggt tttttgcatg ctcttgttca ccttgtcttt 480 gtttacgacc ttcccttctg tggtcccaat gtcattgacc acttcatctg cgacatgtac 540 ccattattaa aacttgcctg cactgacact tacattattg gcctcactgt ggttgccaat 600 gatggggcaa tctgtgtggt catctttacg gtcttgctca tctcctatgg ggtcattctg 660 cactctctga agaaccttag tcaggaaggg aggcgcaaag ccttatccac ctgtggctcc 720 cacattacag tggtggtcct cttctttgtc ccctgcatct tcatgtatgt gagacctcct 780 tctacattac ccattgataa atccttgact gtattttaca cagttatcac tcctatgttg 840 aaccccttaa tctatactct gagaaatgga gagatgaaaa atgccatgga agaagctctg 900 gaccagaaga agaaaatga 919

<210> 2872 <211> 307 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (307)..(307) <223> Any amino acid <400> 2872

Met Glu His Arg Ile Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr 1 5 10 15

Gln Ser Leu Gln Gly Gln Lys Ile Leu Phe Val Val Phe Leu Leu Ile 20 25 30

Tyr Ile Val Thr Met Val Gly Asn Leu Leu Ile Val Val Thr Val Val 35 40 45

Val Ser Pro Thr Leu Asp Ser Pro Met Tyr Phe Phe Leu Gly Tyr Leu 50 55 60

Page 3195

069269_0225_SL.TXT

Ser 65 Phe Met Asp Ala Val Tyr Ser Thr Thr Val Thr Pro Asn Met Ile 70 75 80 Ile Asp Leu Leu Cys Glu Lys Lys Thr Ile Ser Phe Gln Ala Cys Met 85 90 95 Ser Gln Leu Phe Leu Gly His Leu Phe Gly Gly Ala Glu Ile Leu Leu 100 105 110 Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Thr Ile Met Asn Gln Arg Val Cys Val Leu Leu Leu Leu 130 135 140 Leu Ala Trp Val Gly Gly Phe Leu His Ala Leu Val His Leu Val Phe 145 150 155 160 Val Tyr Asp Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Ile 165 170 175 Cys Asp Met Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr Tyr Ile 180 185 190 Ile Gly Leu Thr Val Val Ala Asn Asp Gly Ala Ile Cys Val Val Ile 195 200 205 Phe Thr Val Leu Leu Ile Ser Tyr Gly Val Ile Leu His Ser Leu Lys 210 215 220 Asn Leu Ser Gln Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Ile Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Met Tyr 245 250 255 Val Arg Pro Pro Ser Thr Leu Pro Ile Asp Lys Ser Leu Thr Val Phe 260 265 270

Page 3196

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Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285

Asn Gly Glu Met Lys Asn Ala Met Glu Glu Ala Leu Asp Gln Lys Lys 290 295 300

Lys Met Xaa 305 <210> 2873 <211> 940 <212> DNA <213> Felis catus <400> 2873

tgcagattag atggaagcaa gaaacaatgt aacttacttt gtcctcttgg gtctcacaca 60 ggatccaaag gaacagaagg tcctttttgt tatgttcttg cttttctata ttttcaccat 120 ggtgggaaat ttgctcattg tcatgactgt aactgtcagt aagaccctgg gctcgcctat 180 gtacttgttt cttgctaact tatcatttat ggatgtcact tattcgtctt gcatttcccc 240 aagattgatt tcggacttgt tctttgggga aaacaccata tccttccaat cttgtatgac 300 ccaactattt gtagagcact tttttggtgg atcagaggtt tttcttctgc tggtgatggc 360 ctatgaccgc tatgtggcca tttgtaagcc cttgcattat ttggttatca tgagacagtg 420 ggtgtgtgtt gtgctcctgg tagggtcctg ggttgggggt tttatgcatt cagtaattca 480 agttagcact atttatgggc tcccattctg tggccctaat atcattgatc atttttcctg 540 tgatatgtac cccttactga aactggtctg tactgacacc catgtcattg gcctgttagt 600 ggcggccaac ggaggactga tttgcacaat tgtgtttgtg ctcttgctca tctcttatgg 660 tgtcatcttg cactctctaa agaaccttag tccagaaggg aggcagaaag ccctccagac 720 ctgtggtgcc cacatcactg tggtggtctt cttcttcgtc ccgtgtattt tcatgtacat 780 gagacctgcc aagaccttcc ccgttgacaa gttattgagt gtgttttata cagtcataac 840 ccccatgctg aaccccctga tctacactct gagaaattct gagatgacga atgctatgaa 900 gaaactctgg aggagaaatg ttatatcttt cagtagataa 940

Page 3197

069269_0225_SL.TXT <210> 2874 <211> 309 <212> PRT <213> Felis catus

<400> 2874 Met 1 Glu Ala Arg Asn Asn Val Thr 5 Tyr Phe 10 Val Leu Leu Gly Leu 15 Thr Gln Asp Pro Lys Glu Gln Lys Val Leu Phe Val Met Phe Leu Leu Phe 20 25 30 Tyr Ile Phe Thr Met Val Gly Asn Leu Leu Ile Val Met Thr Val Thr 35 40 45 Val Ser Lys Thr Leu Gly Ser Pro Met Tyr Leu Phe Leu Ala Asn Leu 50 55 60 Ser Phe Met Asp Val Thr Tyr Ser Ser Cys Ile Ser Pro Arg Leu Ile 65 70 75 80 Ser Asp Leu Phe Phe Gly Glu Asn Thr Ile Ser Phe Gln Ser Cys Met 85 90 95 Thr Gln Leu Phe Val Glu His Phe Phe Gly Gly Ser Glu Val Phe Leu 100 105 110 Leu Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Val Ile Met Arg Gln Trp Val Cys Val Val Leu Leu Val 130 135 140 Gly Ser Trp Val Gly Gly Phe Met His Ser Val Ile Gln Val Ser Thr 145 150 155 160 Ile Tyr Gly Leu Pro Phe Cys Gly Pro Asn Ile Ile Asp His Phe Ser 165 170 175 Cys Asp Met Tyr Pro Leu Leu Lys Leu Val Cys Thr Asp Thr His Val 180 185 190

Page 3198

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Ile Gly Leu Leu Val Ala Ala Asn 195 200 Phe Val 210 Leu Leu Leu Ile Ser 215 Tyr Asn 225 Leu Ser Pro Glu Gly 230 Arg Gln His Ile Thr Val Val 245 Val Phe Phe Met Arg Pro Ala 260 Lys Thr Phe Pro Tyr Thr Val 275 Ile Thr Pro Met Leu 280 Asn Ser 290 Glu Met Thr Asn Ala 295 Met Ile Ser Phe Ser Arg

305

Gly Gly Leu Ile Cys 205 Thr Ile Val Gly Val Ile Leu 220 His Ser Leu Lys Lys Ala Leu 235 Gln Thr Cys Gly Ala 240 Phe Val 250 Pro Cys Ile Phe Met 255 Tyr Val 265 Asp Lys Leu Leu Ser 270 Val Phe Asn Pro Leu Ile Tyr 285 Thr Leu Arg Lys Lys Leu Trp 300 Arg Arg Asn Val

<210> 2875 <211> 939 <212> DNA <213> Felis catus <400> 2875 atgggaaata gtaacaatgt gacagaattt gggcaaaaag cattatttgt catgatttta ctgctcattg tggtgactgt ttttggcagc ctcacctatc tgtcactcat ggatgttgtt atagacttac tctgtgacaa aaagacaatt ctagaacact tgtttggggg ttctgaggtc gtcctccttg gcctcacccg ggatcctgaa ctgacctaca ttgtgacaat aatgagcaac ccctctctgg gctcccccat gtacttcttc tattccactg tcatctctcc caaattgatt tccttcccag cttgcatggg ccagctcttc ttcctcctga ttgtgatggc ctatgatcgc

120

180

240

300

360

Page 3199

069269_0225_SL.TXT

tatgtggcca tctgtaggcc gctgcattac ttgactatca tgaatcgaca ggtttgcatt 420 ctgctgttgg tggtggcctg ggttggaggt cttatgcact ctatggttca acttctcttt 480 gtgtacagcc tcccgttttg tggccccaat gtcattgatc acttcatctg tgacatgtac 540 ccattactgg aacttgcctg cactgacacc tacttaatag gcctcactat tgttgccaat 600 ggtggagcca tctgcatggt catctttatc cttctgctca tctcgtatgg agtcattcta 660 aattctctta aaagtcacag tccagaaggg aggcgcaaag ccctgtccac ctgcagttcc 720 cacaccacag tggttgtcct cttttttgtt ccctgcattt tcatgtatgt tagacctgtt 780 tccaacttgt ccattgataa atccataact ctggtttata cagttatcac tcccatgtta 840 aatccgttaa tatacacctt gagaaattcg gagatgaaaa atgctatgga aaaattctgg 900 tgtaaaaatg taaccaaaag taaaataagc atgtgtcac 939 <210> 2876 <211> 313 <212> PRT <213> Felis catus <400> 2876 Met Gly Asn Ser Asn Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr 1 5 10 15 Arg Asp Pro Glu Gly Gln Lys Ala Leu Phe Val Met Ile Leu Leu Thr 20 25 30 Tyr Ile Val Thr Ile Met Ser Asn Leu Leu Ile Val Val Thr Val Phe 35 40 45 Gly Ser Pro Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Thr Tyr Leu 50 55 60 Ser Leu Met Asp Val Val Tyr Ser Thr Val Ile Ser Pro Lys Leu Ile 65 70 75 80 Ile Asp Leu Leu Cys Asp Lys Lys Thr Ile Ser Phe Pro Ala Cys Met 85 90 95 Gly Gln Leu Phe Leu Glu His Leu Phe Gly Gly Ser Glu Val Phe Leu

Page 3200

100

069269_0225_SL.TXT 105 110

Leu Ile Val 115 Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 120 125 His Tyr Leu Thr Ile Met Asn Arg Gln Val Cys Ile Leu Leu Leu Val 130 135 140 Val Ala Trp Val Gly Gly Leu Met His Ser Met Val Gln Leu Leu Phe 145 150 155 160 Val Tyr Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Ile 165 170 175 Cys Asp Met Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr Tyr Leu 180 185 190 Ile Gly Leu Thr Ile Val Ala Asn Gly Gly Ala Ile Cys Met Val Ile 195 200 205 Phe Ile Leu Leu Leu Ile Ser Tyr Gly Val Ile Leu Asn Ser Leu Lys 210 215 220 Ser His Ser Pro Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Thr Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Met Tyr 245 250 255 Val Arg Pro Val Ser Asn Leu Ser Ile Asp Lys Ser Ile Thr Leu Val 260 265 270 Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Met Lys Asn Ala Met Glu Lys Phe Trp Cys Lys Asn Val 290 295 300 Thr Lys Ser Lys Ile Ser Met Cys His

Page 3201

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305

310 <210> 2877 <211> 954 <212> DNA <213> Felis catus <400> 2877

atggaaaata gaaacaatgt gacagagttt gtcctcctgg ggctcacaca ggactctgag 60 gggcaaaaag ttctttttgt cccattctta ctcatctata ttgtgacaat agtgggcaat 120 ctgcttatca tggtgaccat catggccagt ccgtcactgg gttctcccat gtactttttc 180 ctggcttatt tatcatttat agatgctatc tattctactg tcattgctcc caagatgatt 240 gtagacttgc tctatgagaa gaagactatt tccttccagg cttgcatgac tcaagtcttt 300 ctggatcact tatttgctgg tgctgaagtc attcttctgg tggtgatggc ctatgaccga 360 tatgtagcca tctgtaaacc acttcattat ctaatcatca tgaataggag ggtatgtgtt 420 cttatgctgc tggtggcctg gactggaggc tttctgcact cgttggttca gttcatcttt 480 atttatcagc tccctttctg tggccccaat gtcattgaca acttcttgtg tgatatgtat 540 cccttattga aacttgcttg caccaatacc tccctcattg ggatttctat gatagctaat 600 ggaggagcca ttttcactgt catcttcttc attctcctag tttcctatgc agtcatatta 660 cgctctctta agactaatgg tttggaagag aaacgcaaag ccttctacac ctgtgcatcc 720 catataactg tggtcatttt attctttgtt ccctgtatct tcctgtatgc aagggctaat 780 tctacctttc ctattgataa attcatgact gtggttttaa cattcataac ccccatgctg 840 aaccctttaa tctataccct gagaaataaa gaaataaaaa atgccatgag gaagctttgg 900 agtaaaaatc tgacctttgc tggaggaagg ttgtactgct cgtgcagaac atga 954

<210> 2878 <211> 317 <212> PRT <213> Felis catus <400> 2878

Met Glu Asn Arg Asn Asn Val Thr Glu Phe Val Leu Leu Gly Leu Thr 1 5 10 15

Page 3202

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Gln Asp Ser Glu 20 Gly Gln Lys Val Leu Phe Val Pro Phe Leu Leu Ile 25 30 Tyr Ile Val Thr Ile Val Gly Asn Leu Leu Ile Met Val Thr Ile Met 35 40 45 Ala Ser Pro Ser Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu 50 55 60 Ser Phe Ile Asp Ala Ile Tyr Ser Thr Val Ile Ala Pro Lys Met Ile 65 70 75 80 Val Asp Leu Leu Tyr Glu Lys Lys Thr Ile Ser Phe Gln Ala Cys Met 85 90 95 Thr Gln Val Phe Leu Asp His Leu Phe Ala Gly Ala Glu Val Ile Leu 100 105 110 Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Ile Ile Met Asn Arg Arg Val Cys Val Leu Met Leu Leu 130 135 140 Val Ala Trp Thr Gly Gly Phe Leu His Ser Leu Val Gln Phe Ile Phe 145 150 155 160 Ile Tyr Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp Asn Phe Leu 165 170 175 Cys Asp Met Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asn Thr Ser Leu 180 185 190 Ile Gly Ile Ser Met Ile Ala Asn Gly Gly Ala Ile Phe Thr Val Ile 195 200 205 Phe Phe Ile Leu Leu Val Ser Tyr Ala Val Ile Leu Arg Ser Leu Lys 210 215 220

Page 3203

Thr 225 Asn Gly Leu Glu Glu 230 Lys 069269_0225_SL.TXT Arg Lys Ala Phe Tyr Thr 235 Cys Ala Ser 240 His Ile Thr Val Val Ile Leu Phe Phe Val Pro Cys Ile Phe Leu Tyr 245 250 255 Ala Arg Ala Asn Ser Thr Phe Pro Ile Asp Lys Phe Met Thr Val Val 260 265 270 Leu Thr Phe Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Lys Glu Ile Lys Asn Ala Met Arg Lys Leu Trp Ser Lys Asn Leu 290 295 300 Thr Phe Ala Gly Gly Arg Leu Tyr Cys Ser Cys Arg Thr 305 310 315

<210> 2879 <211> 930 <212> DNA <213> Felis catus <400> 2879

aaagaagaca ggatgaatgt gaccgaattc attctaatgg gacttaccca gaatcctcag 60 atgcagagaa ttctattttt ggtgttactt atcatctaca ttgtcactgt cacaggcaac 120 ctgctcattg tggtcactat aatctgcagc cagactttgg actccccaat gtatttcttc 180 ctggcattct tgtctttgat agatgcatgc tattcctcct ccatagtccc taaaatgtta 240 gctgatctgc tctctgattc aaaatcggtt tctttcagtg gctgcatgac acagctcttt 300 gtagaacatt tcttaggagc ttcagagatt gtcctccttg tggtcatggc ctatgaccgc 360 tatgtggcca tctgtagacc cctgcactac atgaccatca tgaaccacca cacatgtcgc 420 ctctttgtgg gggtgtgttg ggcagtgggt tttctccact ccattggaca gattctagtt 480 actttctggc tcccattctg tggtcccaac gtcatggatc acttcatgtg tgacattttc 540 cccctgttac aacttgcctg tactgacact ttccttgtcg gcctcttggt tgttgccaat 600 ggtggagtaa tttctgtgat cacctttgtg atgttattgg tatcctatgt ggtcatcctg 660

Page 3204

069269_0225_SL.TXT tgctccctga agactcacag ctctgcaggg aggaaaaagg ccctctctac ctgtggctcc cacatcacag ttgttgtttt gttcttcgtg ccctgtattt ttatgtatct gagaccagta gctacttttc ccatggataa agtcctaaca ttattctttg ctcttattac tcccatgtta aaccctgtca tctacacagt aaggaataca gaagtaaaaa atgccattag aatgttatta aacagcaatg ccatttcaga aaataaatga

720

780

840

900

930 <210> 2880 <211> 305 <212> PRT <213> Felis catus <400> 2880

Met Asn Val 1 Thr Glu Phe Ile Leu 5 Met Gly Leu Thr Gln Asn Pro Gln 10 15 Met Gln Arg Ile Leu Phe Leu Val Leu Leu Ile Ile Tyr Ile Val Thr 20 25 30 Val Thr Gly Asn Leu Leu Ile Val Val Thr Ile Ile Cys Ser Gln Thr 35 40 45 Leu Asp Ser Pro Met Tyr Phe Phe Leu Ala Phe Leu Ser Leu Ile Asp 50 55 60 Ala Cys Tyr Ser Ser Ser Ile Val Pro Lys Met Leu Ala Asp Leu Leu 65 70 75 80 Ser Asp Ser Lys Ser Val Ser Phe Ser Gly Cys Met Thr Gln Leu Phe 85 90 95 Val Glu His Phe Leu Gly Ala Ser Glu Ile Val Leu Leu Val Val Met 100 105 110 Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu His Tyr Met Thr 115 120 125 Ile Met Asn His His Thr Cys Arg Leu Phe Val Gly Val Cys Trp Ala 130 135 140

Page 3205

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Val 145 Gly Phe Leu His Ser 150 Ile Gly Gln Ile Leu Val Thr Phe Trp Leu 155 160 Pro Phe Cys Gly Pro Asn Val Met Asp His Phe Met Cys Asp Ile Phe 165 170 175 Pro Leu Leu Gln Leu Ala Cys Thr Asp Thr Phe Leu Val Gly Leu Leu 180 185 190 Val Val Ala Asn Gly Gly Val Ile Ser Val Ile Thr Phe Val Met Leu 195 200 205 Leu Val Ser Tyr Val Val Ile Leu Cys Ser Leu Lys Thr His Ser Ser 210 215 220 Ala Gly Arg Lys Lys Ala Leu Ser Thr Cys Gly Ser His Ile Thr Val 225 230 235 240 Val Val Leu Phe Phe Val Pro Cys Ile Phe Met Tyr Leu Arg Pro Val 245 250 255 Ala Thr Phe Pro Met Asp Lys Val Leu Thr Leu Phe Phe Ala Leu Ile 260 265 270 Thr Pro Met Leu Asn Pro Val Ile Tyr Thr Val Arg Asn Thr Glu Val 275 280 285 Lys Asn Ala Ile Arg Met Leu Leu Asn Ser Asn Ala Ile Ser Glu Asn 290 295 300

Lys

305 <210> 2881 <211> 917 <212> DNA <213> Felis catus <400> 2881 atggatagcc tcacacctcc gaacaatgtg actgaatttt ttctcttggg actcacgcag

Page 3206

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aatccacgct tgcagaaaat actcttcgtg gtctttttgt tcatttttct atttactgtg 120 cttgccaatc tgctcgttgt catcaccatc tccctcagcc ccacactttc cgctcccatg 180 tatttctttc ttacttactt gtcttttata gatgcctcct acacctctgt gaccaccccc 240 aaaatgatca tcgacctgct gtatcagagg agaaccatct ccttgggtgg ctgcctgact 300 cagctctttg tggagcactt cctgggagga tcagagatca tcctccttat tgtcatggcc 360 tatgatcgct acgtggccat ctgcaagccc ctgcactaca caaccatcat gcgacagggg 420 ctctgccgcc tcctgctggt ggtggcctgg ctagggggga tcctgcatgc cgctgtgcag 480 acgcttttca tggtcagctt gcccttctgt ggtcccaacg tcattgacca cttcatgtgc 540 gatctcttcc ctctgctgaa acttgcctgc agcgacacct acaggttggg aatggtggtg 600 gcggccaaca gtggggccat gtgcttgctc attttttcca tgctactcgt ctcgtacata 660 gccattctga ggtccctgaa ttcccacggc gccgaaggac gacacaaagc cctctcaaca 720 tgtggctccc actttgccgt agttgtactt ttttttgtgc cttgcatatt cacctacatg 780 cgtcctgtgg tcacctaccc tgtggataag ctggtgaccg tgttctttgc cgtcctcact 840 cccatgttaa atcctatcat ttatacagtg agaaacacag aggtgaaaaa tgccatgagg 900 agtctgtgga agaagag 917

<210> 2882 <211> 306 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (306)..(306) <223> Any amino acid <400> 2882

Met Asp Ser Leu Thr Pro Pro Asn Asn Val Thr Glu Phe Phe Leu Leu 1 5 10 15

Gly Leu Thr Gln Asn Pro Arg Leu Gln Lys Ile Leu Phe Val Val Phe 20 25 30

Page 3207

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Leu Phe Ile 35 Phe Leu Phe Thr Val Leu Ala Asn Leu Leu Val Val Ile 40 45 Thr Ile Ser Leu Ser Pro Thr Leu Ser Ala Pro Met Tyr Phe Phe Leu 50 55 60 Thr Tyr Leu Ser Phe Ile Asp Ala Ser Tyr Thr Ser Val Thr Thr Pro 65 70 75 80 Lys Met Ile Ile Asp Leu Leu Tyr Gln Arg Arg Thr Ile Ser Leu Gly 85 90 95 Gly Cys Leu Thr Gln Leu Phe Val Glu His Phe Leu Gly Gly Ser Glu 100 105 110 Ile Ile Leu Leu Ile Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Lys Pro Leu His Tyr Thr Thr Ile Met Arg Gln Gly Leu Cys Arg Leu 130 135 140 Leu Leu Val Val Ala Trp Leu Gly Gly Ile Leu His Ala Ala Val Gln 145 150 155 160 Thr Leu Phe Met Val Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp 165 170 175 His Phe Met Cys Asp Leu Phe Pro Leu Leu Lys Leu Ala Cys Ser Asp 180 185 190 Thr Tyr Arg Leu Gly Met Val Val Ala Ala Asn Ser Gly Ala Met Cys 195 200 205 Leu Leu Ile Phe Ser Met Leu Leu Val Ser Tyr Ile Ala Ile Leu Arg 210 215 220 Ser Leu Asn Ser His Gly Ala Glu Gly Arg His Lys Ala Leu Ser Thr 225 230 235 240

Page 3208

Cys Gly Ser His Phe 245 Ala Val 069269_0225_SL.TXT Val Val Leu Phe Phe Val 250 Pro Cys 255 Ile Phe Thr Tyr Met Arg Pro Val Val Thr Tyr Pro Val Asp Lys Leu Val 260 265 270 Thr Val Phe Phe Ala Val Leu Thr Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Thr Val Arg Asn Thr Glu Val Lys Asn Ala Met Arg Ser Leu Trp Lys 290 295 300

Lys Xaa 305 <210> 2883 <211> 901 <212> DNA <213> Felis catus <400> 2883

atggagaatc caaacaatgc gactgaattc attcttttgg gcatcacaga gaacccagag 60 ctgcggaaaa cgctctctgc tgtgtttcta atcctgtacg tgtccacggt tttggggaac 120 ctactcatgg tggtaaccgt gatcacaagt cagagcctga ggtcacctat gtattttttc 180 ctcacttcct tgtccctcat ggacgccacc tactgttctg tcattgcccc caagatgatc 240 gtggactcct tctccgagag aactaccatc tcctttgaag gctgcatgac ccaactcttt 300 gcggagcatt tctttggtgg tgtgggggtc atccttctcg tcgtgatggc ctatgaccgc 360 tacgtggcca tctgtaagcc cctgcactac ccgagcatca tgaaccctca ggtgtgccgc 420 ctgctgctgg gaggcgcctg cgtggggggg tttatccacg cagcgataca gcttctcttc 480 atgtatcaaa tacccttctg tggtcccaat gtcatcgatc acttcatgtg tgatttgttc 540 ccattgctga aactcgcctg catggacacc cacaccctgg gtctcttagt catcctcaac 600 agtggggtga tgtgtgtgac catcttcctt atcctcgtgg cctcctacgt ggtcatcctc 660 tgctccctga agtcttgcag ctctgcgggg cggcgcaaag ccctgtcgac ctgtggctcc 720 cacctcactg tggtcgtctt gttcttcgtg ccctgcattt tcctgtacgt gcggcctgtg 780

Page 3209

069269_0225_SL.TXT gccacttacc ccatagacaa agcaatggct gtgtccttta ccattgttgc acccatgtta aaccccctga tctacacctt gaggaatgca gaggtgaaaa atgccatgag gaaattgtgg ^g

840

900

901 <210> 2884 <211> 301 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (301)..(301) <223> Any amino acid

<400> 2884 Thr Met 1 Glu Asn Pro Asn Asn 5 Ala Thr Glu Phe 10 Ile Leu Leu Gly Ile 15 Glu Asn Pro Glu Leu Arg Lys Thr Leu Ser Ala Val Phe Leu Ile Leu 20 25 30 Tyr Val Ser Thr Val Leu Gly Asn Leu Leu Met Val Val Thr Val Ile 35 40 45 Thr Ser Gln Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Thr Ser Leu 50 55 60 Ser Leu Met Asp Ala Thr Tyr Cys Ser Val Ile Ala Pro Lys Met Ile 65 70 75 80 Val Asp Ser Phe Ser Glu Arg Thr Thr Ile Ser Phe Glu Gly Cys Met 85 90 95 Thr Gln Leu Phe Ala Glu His Phe Phe Gly Gly Val Gly Val Ile Leu 100 105 110 Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Pro Ser Ile Met Asn Pro Gln Val Cys Arg Leu Leu Leu Gly

Page 3210

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130 135 Ile His Ala 140 Ala Ile Gln Leu Leu Phe Gly 145 Ala Cys Val Gly Gly 150 Phe 155 160 Met Tyr Gln Ile Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met 165 170 175 Cys Asp Leu Phe Pro Leu Leu Lys Leu Ala Cys Met Asp Thr His Thr 180 185 190 Leu Gly Leu Leu Val Ile Leu Asn Ser Gly Val Met Cys Val Thr Ile 195 200 205 Phe Leu Ile Leu Val Ala Ser Tyr Val Val Ile Leu Cys Ser Leu Lys 210 215 220 Ser Cys Ser Ser Ala Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Leu Thr Val Val Val Leu Phe Phe Val Pro Cys Ile Phe Leu Tyr 245 250 255 Val Arg Pro Val Ala Thr Tyr Pro Ile Asp Lys Ala Met Ala Val Ser 260 265 270 Phe Thr Ile Val Ala Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp Xaa 290 295 300 <210> 2885 <211> 936 <212> DNA <213> Felis catus <400> 2885 atgcgaaacc aaagctttgt aactgagttc gtcctcctgg ggctttcgca gaatcccagt gttcagaaaa tagtatttgt tgtattcttg ttcagctaca ttgcaactgt cgggggcaac

120

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ttgctaattg tggtgaccgt cagcagcagc ccagcactcc tgggctcccc catgtacttc 180 ttcttggctt tcctgtcctt cctcgatgct tgcttctcca ctgtcattgc cccaaagatg 240 attgtggact ccctctatga gaggaaaacc atctcctttg gaggttgcat gacccagctc 300 tttgctgaac acttctttgc tggggtggaa gtgattgtcc tcacagccat ggcctacgac 360 cgctatgtgg ccatctgcaa gcccctacgc tacacaacca ttatgaactg gaggctctgt 420 accattctga tgggtgtagc ctggacaggg ggttttctgc attccatgat acaaattctc 480 tttactttcc agcttccctt ctgcggcccc aatgtcattg atcacttcat gtgtgatttg 540 tacccgttat tggagcttgc ctgcactgac actcacatct ttggcctttt ggtggttgcc 600 aatagtgggt ctatctgcat tataatcttc tctctgttac tcgtctccta tgttgtcatc 660 ttgctctctc tgagaaccca tagtcctgaa gggcagcgga aagccctctc cacgtgcgga 720 tctcacattg ctattgtggt cttgttcttt gtcccttgca tatttgtgta tgcacgacct 780 ccatctgctt tctcttttga caaaatggtg gctatatttt acaccatcct aactcccttg 840 ctcaatcctt tgatttacac tttcaggaac aaggaaatga aaaatgccat aaagaaaatg 900 tggaacagaa taatggtggt ttgtagtgac aaataa 936

<210> 2886 <211> 311 <212> PRT <213> Felis catus <400> 2886

Met Arg Asn Gln Ser Phe Val Thr Glu Phe Val Leu Leu Gly Leu Ser 1 5 10 15 Gln Asn Pro Ser Val Gln Lys Ile Val Phe Val Val Phe Leu Phe Ser 20 25 30 Tyr Ile Ala Thr Val Gly Gly Asn Leu Leu Ile Val Val Thr Val Ser 35 40 45 Ser Ser Pro Ala Leu Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Phe 50 55 60

Page 3212

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Leu 65 Ser Phe Leu Asp Ala Cys Phe Ser Thr Val Ile Ala Pro Lys Met 70 75 80 Ile Val Asp Ser Leu Tyr Glu Arg Lys Thr Ile Ser Phe Gly Gly Cys 85 90 95 Met Thr Gln Leu Phe Ala Glu His Phe Phe Ala Gly Val Glu Val Ile 100 105 110 Val Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro 115 120 125 Leu Arg Tyr Thr Thr Ile Met Asn Trp Arg Leu Cys Thr Ile Leu Met 130 135 140 Gly Val Ala Trp Thr Gly Gly Phe Leu His Ser Met Ile Gln Ile Leu 145 150 155 160 Phe Thr Phe Gln Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe 165 170 175 Met Cys Asp Leu Tyr Pro Leu Leu Glu Leu Ala Cys Thr Asp Thr His 180 185 190 Ile Phe Gly Leu Leu Val Val Ala Asn Ser Gly Ser Ile Cys Ile Ile 195 200 205 Ile Phe Ser Leu Leu Leu Val Ser Tyr Val Val Ile Leu Leu Ser Leu 210 215 220 Arg Thr His Ser Pro Glu Gly Gln Arg Lys Ala Leu Ser Thr Cys Gly 225 230 235 240 Ser His Ile Ala Ile Val Val Leu Phe Phe Val Pro Cys Ile Phe Val 245 250 255 Tyr Ala Arg Pro Pro Ser Ala Phe Ser Phe Asp Lys Met Val Ala Ile 260 265 270

Page 3213

0 6926 9_02 25_S L.TX T Phe Tyr Thr Ile Leu Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Phe 275 280 285 Arg Asn Lys Glu Met Lys Asn Ala Ile Lys Lys Met Trp Asn Arg Ile 290 295 300 Met Val Val Cys Ser Asp Lys 305 310

<210> 2887 <211> 915 <212> DNA <213> Felis catus <400> 2887

atggagtcga atagcagtgt gaatgagttc gttctctttg ggttaacaca gaatgttgta 60 aagggaaaag tagtgtttgt ggtcttcttg tttctatacc tcgcaaccct tttggcaaat 120 ttacttattg tgatgaccat aagatacagc cggacacttg ggagccccat gtacttcttc 180 cttttctact tatcctttgc tgatgcctgc ttctcaacaa ccactgctcc taggttaata 240 gtagattctg tatctgagaa gaaagtcatc tcctacaacg agtgcatgac ccaggttttt 300 gcagttcact tatttgggtg catggagatc ttggtgctta tcctcatgtc ctttgatcgc 360 tatgtggcca tttgtaagcc cctgcgatac actatcatca tgagccggca tgtctgtggt 420 acagtggtga gtctagcctg ggtggtgtct tgtatccatt cttctgcaca gattttcttg 480 gctttgaaac tacccttctg tggacccaat gttattgatc attatttctg tgatatgcca 540 cctttgttga aactcgcatg catggacacc tatgtaatca atttactcat agtttttaac 600 agtggggcta tctgtatggt gagtttcgtc gtcctgcttc tctcttatat tttcatctta 660 cattctctga ataaccagag tgcagaagga agaaagaaag ccttctctac gtgcacatcc 720 cacatcatcg ttgtcatctt attctttgtt ccatgtatat tcacatatac tcgccctgta 780 actacgtttc cagtggataa gatggtggct gtgttttaca ctattgggac acccttgctc 840 aaccctctga tttatactct gagaaatgca gaagtgaaga atgcaatgag gaagttatgg 900 ggcggcaaac tctga 915

<210> 2888

Page 3214

069269_0225_SL.TXT <211> 304 <212> PRT <213> Felis catus

<400> 2888 Leu 15 Thr Met 1 Glu Ser Asn Ser Ser Val Asn 5 Glu Phe 10 Val Leu Phe Gly Gln Asn Val Val Lys Gly Lys Val Val Phe Val Val Phe Leu Phe Leu 20 25 30 Tyr Leu Ala Thr Leu Leu Ala Asn Leu Leu Ile Val Met Thr Ile Arg 35 40 45 Tyr Ser Arg Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Phe Ala Asp Ala Cys Phe Ser Thr Thr Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ser Val Ser Glu Lys Lys Val Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ala Val His Leu Phe Gly Cys Met Glu Ile Leu Val 100 105 110 Leu Ile Leu Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Ile Ile Met Ser Arg His Val Cys Gly Thr Val Val Ser 130 135 140 Leu Ala Trp Val Val Ser Cys Ile His Ser Ser Ala Gln Ile Phe Leu 145 150 155 160 Ala Leu Lys Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe 165 170 175 Cys Asp Met Pro Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190

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Ile Asn Leu Leu Ile Val 195 Phe Asn Ser Gly Ala Ile Cys Met Val Ser 200 205 Phe Val Val Leu Leu Leu Ser Tyr Ile Phe Ile Leu His Ser Leu Asn 210 215 220 Asn Gln Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Thr Ser 225 230 235 240 His Ile Ile Val Val Ile Leu Phe Phe Val Pro Cys Ile Phe Thr Tyr 245 250 255 Thr Arg Pro Val Thr Thr Phe Pro Val Asp Lys Met Val Ala Val Phe 260 265 270 Tyr Thr Ile Gly Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Ala Glu Val Lys Asn Ala Met Arg Lys Leu Trp Gly Gly Lys Leu 290 295 300

<210> 2889 <211> 911 <212> DNA <213> Felis catus <400> 2889 cgatgaatag cagtgtgact gaattcattc tccttgggct gacacaggat ccggtaaagc 60 agaaggcagt attcggggtc ttcttgatct tttaccttgc gacactgttg gggaactttc 120 tcattgtagt gactatcaaa acaagcagga cccttgggac tcccatgtac ttcttcctat 180 tctatctgtc ttttgctgac acctgcttct ctacaaccac agcccccaga ttgattgtgg 240 atgccctttc tcacaagaag accatttcct acaatgagtg catgattcag gtctttacat 300 tccatttctt tgggtgcatg gaaatcttgg tgctcatcct catggcttta gatcgctatg 360 tggccatttg taagcccttg cgatacacaa ccatcatgaa ccggcaagtg tgcagcgttt 420 tggtgattct agtgtgggtg gcatcttgta tccactcttt ggcacaaatt ttcctgactt 480 tgagattgcc tttctgtggc cccaacgtga ttgaccacta tttctgtgac ttgcagccct 540

Page 3216

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tgttgaaact tgcctgcatg gacacttatg tgacaaattt gctacttgtt tctaacagtg 600 gaaccatatg cacggtgagt ttcataatcc tgcttacctc ctatgttgtc atcttgtact 660 ctctgcgtaa ccacagtgct gaaggaaggc gaaaagccct ttccacctgc acctcccact 720 ttattgtggt tgtcttattt tttggtccat gcatattcat atacacacgc cccccagcta 780 catttccaat agacaaaatg gtggctgtgt tttatacaat tgggacgccc ctgctcaacc 840 ctctgatcta tacactgagg aatatggaag tgaaaaaagc catgaagaaa ttatggtgta 900 gcaaagaatg a 911

<210> 2890 <211> 302 <212> PRT <213> Felis catus

<400> 2890 Thr Glu Phe Ile Leu Leu Gly Leu Thr Gln Asp Met 1 Asn Ser Ser Val 5 10 15 Pro Val Lys Gln Lys Ala Val Phe Gly Val Phe Leu Ile Phe Tyr Leu 20 25 30 Ala Thr Leu Leu Gly Asn Phe Leu Ile Val Val Thr Ile Lys Thr Ser 35 40 45 Arg Thr Leu Gly Thr Pro Met Tyr Phe Phe Leu Phe Tyr Leu Ser Phe 50 55 60 Ala Asp Thr Cys Phe Ser Thr Thr Thr Ala Pro Arg Leu Ile Val Asp 65 70 75 80 Ala Leu Ser His Lys Lys Thr Ile Ser Tyr Asn Glu Cys Met Ile Gln 85 90 95 Val Phe Thr Phe His Phe Phe Gly Cys Met Glu Ile Leu Val Leu Ile 100 105 110 Leu Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu Arg Tyr 115 120 125

Page 3217

069269_0225_SL.TXT

Thr Thr Ile 130 Met Asn Arg Gln Val Cys Ser Val Leu Val Ile Leu Val 135 140 Trp Val Ala Ser Cys Ile His Ser Leu Ala Gln Ile Phe Leu Thr Leu 145 150 155 160 Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe Cys Asp 165 170 175 Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val Thr Asn 180 185 190 Leu Leu Leu Val Ser Asn Ser Gly Thr Ile Cys Thr Val Ser Phe Ile 195 200 205 Ile Leu Leu Thr Ser Tyr Val Val Ile Leu Tyr Ser Leu Arg Asn His 210 215 220 Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser His Phe 225 230 235 240 Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr Thr Arg 245 250 255 Pro Pro Ala Thr Phe Pro Ile Asp Lys Met Val Ala Val Phe Tyr Thr 260 265 270 Ile Gly Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Met 275 280 285 Glu Val Lys Lys Ala Met Lys Lys Leu Trp Cys Ser Lys Glu 290 295 300

<210> 2891 <211> 912 <212> DNA <213> Felis catus <400> 2891

Page 3218

069269_0225_SL.TXT gcgatgaata gcagtgtgac tgaattcatt ctccttgggt tgactcggga tgcaggaaag 60 cagaaggcag tatttggtgt cttcttgatt ctttaccttt cgacactgtc ggggaacttt 120 ctcattgtag tgactattaa aataagcaag acccttggga gtcccatgta cttcttcctg 180 ttctatctgt cttttgctga cgcctgcttc tctacaacca cagcccccag attgattgtg 240 gatgcccttg ctcagaagaa gaccatttcc tacaatgagt gcatgactca ggtctttgca 300 gcccatttct ttgggtgcat ggaaatcttg gtgctcatcc tcatggcttt tgatcgctat 360 gtagctattt gtaagccatt gcaatacaca accatcatga accggcacgt gtgcagtgtt 420 ttggtgattc tagcctgggt gggatcttgt atccactctt cagcacaaat tttcctggct 480 ttgagattgc ctttctgtgg ccccaacgtg attgaccact atttctgtga cttgcagccc 540 ttgttgaaac ttgcctgtat ggacacttat gtgacaaatt tgctagttgt ttccaacagt 600 ggggccatat gcacggtgag tttcataatc ctgcttacct cctatgttgt catcttgtac 660 tctctgcgta accacagtgc tgaaggaagg cgaaaagccc tttccacctg cacctcccac 720 tttattgtgg ttgtcttatt ttttggtcca tgcatattca tatacacacg cccaccaacc 780 acatttccaa tagacaagac agtggctgtg ttttatacaa ttgggacacc cttgctcaac 840 cctctgatct ataccctgag gaatatggaa gtgaaaaaag ccatgaagaa attatggtgt 900 agcaaagtat ga 912 <210> 2892 <211> 302 <212> PRT <213> Felis catus

<400> 2892 Met 1 Asn Ser Ser Val Thr Glu Phe Ile Leu Leu Gly Leu Thr Arg Asp 5 10 15 Ala Gly Lys Gln Lys Ala Val Phe Gly Val Phe Leu Ile Leu Tyr Leu 20 25 30 Ser Thr Leu Ser Gly Asn Phe Leu Ile Val Val Thr Ile Lys Ile Ser 35 40 45 Lys Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu Ser Phe Page 3219

069269_0225_SL.TXT

50 55 60

Ala 65 Asp Ala Cys Phe Ser Thr Thr Thr Ala Pro Arg Leu Ile Val Asp 70 75 80 Ala Leu Ala Gln Lys Lys Thr Ile Ser Tyr Asn Glu Cys Met Thr Gln 85 90 95 Val Phe Ala Ala His Phe Phe Gly Cys Met Glu Ile Leu Val Leu Ile 100 105 110 Leu Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu Gln Tyr 115 120 125 Thr Thr Ile Met Asn Arg His Val Cys Ser Val Leu Val Ile Leu Ala 130 135 140 Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Phe Leu Ala Leu 145 150 155 160 Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe Cys Asp 165 170 175 Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val Thr Asn 180 185 190 Leu Leu Val Val Ser Asn Ser Gly Ala Ile Cys Thr Val Ser Phe Ile 195 200 205 Ile Leu Leu Thr Ser Tyr Val Val Ile Leu Tyr Ser Leu Arg Asn His 210 215 220 Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser His Phe 225 230 235 240 Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr Thr Arg 245 250 255 Pro Pro Thr Thr Phe Pro Ile Asp Lys Thr Val Ala Val Phe Tyr Thr

Page 3220

260

069269_0225_SL.TXT 265 270

Ile Gly Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Met 275 280 285

Glu Val Lys Lys Ala Met Lys Lys Leu Trp Cys Ser Lys Val 290 295 300

<210> 2893 <211> 901 <212> DNA <213> Felis catus <400> 2893

cccacagttt ccccatggca gttttcacct ctgcgttcct cagggtgtag atcagggggt 60 ttaacatggg cgtgatgatg gaatcagaca cggccattgc cttgtctatg gggtaagtgg 120 ccacaggccg cacgtacagg aaaatgcagg gcacgaagaa caagatgacc acagtgaggt 180 gggagccaca ggtcgacagg gctttgcgcc gccccgcaga gctgcaagac ttcagggagc 240 agaggatgac cacgtaggag gccacgagga taaggaagat ggtcacacac atcaccccac 300 tgttgaggat gactaagaga cccagggcat gggtgtccat gcaggcgagt ttcagcaatg 360 ggaacaaatc acatatgaag tgatcgatga cattgggacc acagaagggt atttgataca 420 tgaagagaag ctgtatcgct gcgtggataa acccccccac gcaggcgcct cccagcagca 480 ggcggcacac ctgagggttc atgatgctcg ggtagtgcag gggcttacag atggccacgt 540 agcggtcata ggccatcacg acgagaagga tgacccccac accaccaaag aaatgctccg 600 caaagagctg ggccatgcag ccttcaaagg agatggtagt tctctcggag aaggagtcca 660 cgatcatctt gggggcaatg acggaacagt aggtggcgtc catgagggac aaggaagtga 720 gaaaaaaata cataggtgat ctcaggctct gacttgtgat cacggttacc accatgagta 780 ggttccccaa aaccgtggac acgtacagga ttagaaacac agcagagagc gttttccgca 840 gctctgggtt ctctgtgatg cccaaaagaa tgaattcagt cgcattgttt ggattctcca 900

t 901 <210> 2894 <211> 301

Page 3221

069269_0225_SL.TXT <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (301)..(301) <223> Any amino acid

<400> 2894 Met 1 Glu Asn Pro Asn 5 Asn Ala Thr Glu Phe Ile Leu Leu Gly Ile Thr 10 15 Glu Asn Pro Glu Leu Arg Lys Thr Leu Ser Ala Val Phe Leu Ile Leu 20 25 30 Tyr Val Ser Thr Val Leu Gly Asn Leu Leu Met Val Val Thr Val Ile 35 40 45 Thr Ser Gln Ser Leu Arg Ser Pro Met Tyr Phe Phe Leu Thr Ser Leu 50 55 60 Ser Leu Met Asp Ala Thr Tyr Cys Ser Val Ile Ala Pro Lys Met Ile 65 70 75 80 Val Asp Ser Phe Ser Glu Arg Thr Thr Ile Ser Phe Glu Gly Cys Met 85 90 95 Ala Gln Leu Phe Ala Glu His Phe Phe Gly Gly Val Gly Val Ile Leu 100 105 110 Leu Val Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Pro Ser Ile Met Asn Pro Gln Val Cys Arg Leu Leu Leu Gly 130 135 140 Gly Ala Cys Val Gly Gly Phe Ile His Ala Ala Ile Gln Leu Leu Phe 145 150 155 160 Met Tyr Gln Ile Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Ile 165 170 175

Page 3222

069269_0225_SL.TXT

Cys Asp Leu Phe 180 Pro Leu Leu Lys Leu Gly Leu 195 Leu Val Ile Leu Asn 200 Phe Leu 210 Ile Leu Val Ala Ser 215 Tyr Ser 225 Cys Ser Ser Ala Gly 230 Arg Arg His Leu Thr Val Val 245 Ile Leu Phe Val Arg Pro Val 260 Ala Thr Tyr Pro Asp Ser Ile 275 Ile Thr Pro Met Leu 280 Asn Ala 290 Glu Val Lys Thr Ala 295 Met

Leu Ala Cys Met Asp Thr His Ala 185 190 Ser Gly Val Met Cys 205 Val Thr Ile Val Val Ile Leu 220 Cys Ser Leu Lys Lys Ala Leu 235 Ser Thr Cys Gly Ser 240 Phe Val 250 Pro Cys Ile Phe Leu 255 Tyr Ile 265 Asp Lys Ala Met Ala 270 Val Ser Asn Pro Leu Ile Tyr 285 Thr Leu Arg Gly Lys Leu Trp 300 Xaa

<210> 2895 <211> 912 <212> DNA <213> Felis catus <400> 2895 gcgatgaata gcagtgtgac tgaattcatt cagaaggcag tatttggggt cttcttgatt ctcattttgg tgactattaa aacaagcaag ttctatctgt cgttttctga tgcttgcctc ggtgccatta ctcagaagaa taccatttcg gctcatttct ttgggtgcct ggaaatcttc ctgtttgggt tgacacagga tgcaggaaag ctttaccttg caacactgtt ggggaacttt acccttggga gtcccatgta cttcttccta tctacaacca ctgcccccag attgattgtg tacaatgagt gcatgactca ggtctttgca gtgctcatcc tcatggcttt tgatcgctac

120

180

240

300

360

Page 3223

069269_0225_SL.TXT

atagctattt gtaagccctt gcgatacaca accctcatga gccagcatgt ctgcagtgtg 420 ctgatgattt tgagctgggt gggatcctgt atccactctt cagcacaaat tttcctggct 480 ttgagattgc ctttctgtgg ccccaacgtg attgaccact atttctgtga ctttcagccc 540 ttgttgaaac ttgcctgtat ggacacttac gtgataaatt tgctacttgt ttctaacagt 600 ggggccatat gcacggtgag tttcataatc ctgcttacct cctatgttgt catcttgtac 660 tctctgcgaa accacagtgc tgaaggaagg cgaaaagccc tttccacctg cacctcccac 720 tttattgtgg ttgtcctatt ttttggtcca tgtatattca tatacacacg cccaccaacc 780 acatttccaa tagacaagat ggtggctgtg ttttatacaa ttgggacgcc cttgctcaac 840 cctctgatct ataccctgag gaatgttgaa gtgaaaaatg ccatgaaaaa gttatggtgt 900 agcaaagtat ga 912 <210> 2896 <211> 302 <212> PRT <213> Felis catus <400> 2896 Met Asn Ser Ser Val Thr Glu Phe Ile Leu Phe Gly Leu Thr Gln Asp 1 5 10 15 Ala Gly Lys Gln Lys Ala Val Phe Gly Val Phe Leu Ile Leu Tyr Leu 20 25 30 Ala Thr Leu Leu Gly Asn Phe Leu Ile Leu Val Thr Ile Lys Thr Ser 35 40 45 Lys Thr Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu Ser Phe 50 55 60 Ser Asp Ala Cys Leu Ser Thr Thr Thr Ala Pro Arg Leu Ile Val Gly 65 70 75 80 Ala Ile Thr Gln Lys Asn Thr Ile Ser Tyr Asn Glu Cys Met Thr Gln 85 90 95 Val Phe Ala Ala His Phe Phe Gly Cys Leu Glu Ile Phe Val Leu Ile

Page 3224

100

069269_0225_SL.TXT 105 110

Leu Met Ala 115 Phe Asp Arg Tyr Ile Ala 120 Ile Cys Lys Pro Leu 125 Arg Tyr Thr Thr Leu Met Ser Gln His Val Cys Ser Val Leu Met Ile Leu Ser 130 135 140 Trp Val Gly Ser Cys Ile His Ser Ser Ala Gln Ile Phe Leu Ala Leu 145 150 155 160 Arg Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe Cys Asp 165 170 175 Phe Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val Ile Asn 180 185 190 Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Thr Val Ser Phe Ile 195 200 205 Ile Leu Leu Thr Ser Tyr Val Val Ile Leu Tyr Ser Leu Arg Asn His 210 215 220 Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Thr Ser His Phe 225 230 235 240 Ile Val Val Val Leu Phe Phe Gly Pro Cys Ile Phe Ile Tyr Thr Arg 245 250 255 Pro Pro Thr Thr Phe Pro Ile Asp Lys Met Val Ala Val Phe Tyr Thr 260 265 270 Ile Gly Thr Pro Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Val 275 280 285 Glu Val Lys Asn Ala Met Lys Lys Leu Trp Cys Ser Lys Val 290 295 300 <210> 2897

Page 3225

069269_0225_SL.TXT <211> 927 <212> DNA <213> Felis catus <400> 2897

ctgaataata atgtgacaga gttcattctc cttgggttga cccaggatcc tgttaggaag 60 aaaatagtgt ttgtcacttt cttgcttttc tatttgggga cattgctggg taactttctg 120 atcattacta ctatcaagac cagccgggcc cttgggagtc caatgtactt tttccttttc 180 cacttgtcct tatctgacac ctgtttctgt agttccgtag cccctagaat gattgtggat 240 gcctttttga agaagagcac tatctctttc agtgagtgca tgatacaggt cttctcattc 300 catttctttg gctgcctgga gatcttcatt cttatcctca tggccgctga ccgctatgtg 360 gccatctgta agcccctgca ctacacaacc atcatgagtc aacgggtctg tgctgtgctg 420 gtggctatgg cctgggtggg gtcctgtgta cattctttag ctcagatttt tctggccttg 480 agtttaccct tctgtggtcc caatgtgatc gatcactatt tttgtgactt gcagccattg 540 ttgagactcg cctgtacaga cacttacgta atcaatctac tcttggtgtc caatagcggg 600 gccatttgta ccctgagttt tgtcatgctg atgtgctcct atgttaatat cttgtattct 660 ctgagaaacc acagtgctga agggaggaga aaagccctct ccacctgtgt ctcccacatc 720 attgtggtca tcttgttctt cggtccttgc atatttatat acacacgccc tgcaaccacc 780 ttccccatgg ataagatgat agctgtattt tatacacttg gaacaccttt gatcaatcct 840 ctgatttaca cgctgaggaa tgcagaagtg aaaaacgcca tgaggaaatt atggaagaag 900 aagttaatct taggtgacaa aagatga 927

<210> 2898 <211> 308 <212> PRT <213> Felis catus <400> 2898

Leu Asn Asn Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr Gln Asp 1 5 10 15

Pro Val Arg Lys Lys Ile Val Phe Val Thr Phe Leu Leu Phe Tyr Leu 20 25 30

Page 3226

069269_0225_SL.TXT

Gly Thr Leu 35 Leu Gly Asn Phe Leu Ile Ile Thr Thr Ile Lys Thr Ser 40 45 Arg Ala Leu Gly Ser Pro Met Tyr Phe Phe Leu Phe His Leu Ser Leu 50 55 60 Ser Asp Thr Cys Phe Cys Ser Ser Val Ala Pro Arg Met Ile Val Asp 65 70 75 80 Ala Phe Leu Lys Lys Ser Thr Ile Ser Phe Ser Glu Cys Met Ile Gln 85 90 95 Val Phe Ser Phe His Phe Phe Gly Cys Leu Glu Ile Phe Ile Leu Ile 100 105 110 Leu Met Ala Ala Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr 115 120 125 Thr Thr Ile Met Ser Gln Arg Val Cys Ala Val Leu Val Ala Met Ala 130 135 140 Trp Val Gly Ser Cys Val His Ser Leu Ala Gln Ile Phe Leu Ala Leu 145 150 155 160 Ser Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Tyr Phe Cys Asp 165 170 175 Leu Gln Pro Leu Leu Arg Leu Ala Cys Thr Asp Thr Tyr Val Ile Asn 180 185 190 Leu Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Thr Leu Ser Phe Val 195 200 205 Met Leu Met Cys Ser Tyr Val Asn Ile Leu Tyr Ser Leu Arg Asn His 210 215 220 Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Val Ser His Ile 225 230 235 240

Page 3227

Ile Val Val Ile Leu 245 Phe Phe 069269_0225_SL.TXT Gly Pro Cys Ile Phe Ile 250 Tyr Thr 255 Arg Pro Ala Thr Thr Phe Pro Met Asp Lys Met Ile Ala Val Phe Tyr Thr 260 265 270 Leu Gly Thr Pro Leu Ile Asn Pro Leu Ile Tyr Thr Leu Arg Asn Ala 275 280 285 Glu Val Lys Asn Ala Met Arg Lys Leu Trp Lys Lys Lys Leu Ile Leu 290 295 300

Gly Asp Lys Arg 305 <210> 2899 <211> 927 <212> DNA <213> Felis catus <400> 2899

atgggacatg aaaacatcac agaatttatc ctcctgggac ttttcagtga tgaggatgca 60 aagattgcct gctttgtgct gttctcgctt tgctatattg caattctctc cggaaacctg 120 cttgttcttc ttaccatcag gggcagccgc ctcagtgaac agcccatgta ctttttcctg 180 agctacctgt ctttcatgga tgtctgcttc acctccacag tggcccccaa actgatcaca 240 gatctgctgg cccggcggaa gactatctct tacaacagct gcatggccca gatgttttat 300 gcccacttct ttggtgccac tgagatcttc atcttggtgg ccatggctta tgaccgttat 360 gcagccatct gcagacccct tcactatatg gtcatcatga gcagaccggt gtgctatatc 420 attgtgatgg cctcgattat cggagcattc atccattcaa tcctccacgt attgattatt 480 gtcgaacttc ccttctgtgg ccccaatcgg atagaccact atttctgtga tgttttcccc 540 ttgctgaagc tggcttgcat ggacactagc ctgttggtta ttgtgatcat taccaccaca 600 ggagtgatgt ccattttgac ctttgttgcc ttggtaattt cttacctcat catcctgtcc 660 accctgagga cccgctcatc ccagggccgc cgcaaagccc tctctacctg cagctctcac 720 gtcactgtcg tgttcctgtt cttcctgccc ctcatcttca cgtatgtccc cgtggctgat 780

Page 3228

069269_0225_SL.TXT tctgtcagta acgacaaggt ttttgccctg ttttacacca tgattgctcc catgttcaac cctctcatct acacgctgag aaacacagac atgaagaacg ccatgaggaa agtgtggtgt tggcacaaac ggactgaagg gaaatga

840

900

927 <210> 2900 <211> 308 <212> PRT <213> Felis catus

<400> 2900 Ile Thr Glu Phe Ile Leu Leu Gly Leu Phe Ser Met Gly 1 His Glu Asn 5 10 15 Asp Glu Asp Ala Lys Ile Ala Cys Phe Val Leu Phe Ser Leu Cys Tyr 20 25 30 Ile Ala Ile Leu Ser Gly Asn Leu Leu Val Leu Leu Thr Ile Arg Gly 35 40 45 Ser Arg Leu Ser Glu Gln Pro Met Tyr Phe Phe Leu Ser Tyr Leu Ser 50 55 60 Phe Met Asp Val Cys Phe Thr Ser Thr Val Ala Pro Lys Leu Ile Thr 65 70 75 80 Asp Leu Leu Ala Arg Arg Lys Thr Ile Ser Tyr Asn Ser Cys Met Ala 85 90 95 Gln Met Phe Tyr Ala His Phe Phe Gly Ala Thr Glu Ile Phe Ile Leu 100 105 110 Val Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Arg Pro Leu His 115 120 125 Tyr Met Val Ile Met Ser Arg Pro Val Cys Tyr Ile Ile Val Met Ala 130 135 140 Ser Ile Ile Gly Ala Phe Ile His Ser Ile Leu His Val Leu Ile Ile 145 150 155 160

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069269_0225_SL.TXT

Val Glu Leu Pro Phe Cys Gly Pro Asn Arg Ile Asp His Tyr Phe Cys 165 170 175 Asp Val Phe Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Ser Leu Leu 180 185 190 Val Ile Val Ile Ile Thr Thr Thr Gly Val Met Ser Ile Leu Thr Phe 195 200 205 Val Ala Leu Val Ile Ser Tyr Leu Ile Ile Leu Ser Thr Leu Arg Thr 210 215 220 Arg Ser Ser Gln Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser Ser His 225 230 235 240 Val Thr Val Val Phe Leu Phe Phe Leu Pro Leu Ile Phe Thr Tyr Val 245 250 255 Pro Val Ala Asp Ser Val Ser Asn Asp Lys Val Phe Ala Leu Phe Tyr 260 265 270 Thr Met Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg Asn 275 280 285 Thr Asp Met Lys Asn Ala Met Arg Lys Val Trp Cys Trp His Lys Arg 290 295 300 Thr Glu Gly Lys

305 <210> 2901 <211> 936 <212> DNA <213> Felis catus <400> 2901 ctacttacca ttagcttctg ggaaaacctt cctgccccac agtcttttca ttgcattctt tacttccgca tttctcagtg tataaatcag gggatttaac atgggggtga taatggtgta aaatacagcc accatcttgt cctctgaaaa ggtagtatca gggcgcatat acatgaaggt

120

180

Page 3230

069269_0225_SL.TXT acagggacca aaaaagatga tgaccacagc aatgtgggag ccacaggtgg agagtgcttt gagcctgctt tctgctgagt gctttctcag ggacaccagg atgatggtat aggaaatgat caagataaca aagctcccca gagcaatggt accactgttg gctgtcacca caacaccaac gatgtatgtg tctgtgcagg caagtttcag cacagggtgg atatcacaaa agtagtgatc gatctcattg ggtccacaaa agggtaacgg gactaccaga gccacttgga taatggagtg taagaacccc cctatccacg tccccagcaa cattttattg catctgtcac agcccatgat ggtcgtatag tgtaggggtt tacagatagc cacataacga tcataggcca ttacggtaag gatgaagatc tcagtgcaac caaagaaatg taccccaaag agttgcaaca tgcaccccac ataggagatg gttttgctct tggctaatag gtcaacaatc atcttaggag ctgtgaccga agagtaacaa atatccacaa aagacaagta gctgaggaag aaatacatag gagacttgaa aagcttgccc ctataaatgg tcagcatgat gaggaggttt cccagaagaa tgaccgtgta gaagaaagaa aacaccacga aacaaacctc ttcaacttct aggttctgag aaagacccca gaaaatgaat tcagttacat tgtttatttt ttccat <210> 2902 <211> 311 <212> PRT <213> Felis catus

240

300

360

420

480

540

600

660

720

780

840

900

936

<400> 2902 Met Glu Lys Ile 1 Asn 5 Asn Val Thr Glu Phe Ile Phe Trp Gly Leu Ser 10 15 Gln Asn Leu Glu Val Glu Glu Val Cys Phe Val Val Phe Ser Phe Phe 20 25 30 Tyr Thr Val Ile Leu Leu Gly Asn Leu Leu Ile Met Leu Thr Ile Tyr 35 40 45 Arg Gly Lys Leu Phe Lys Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu 50 55 60 Ser Phe Val Asp Ile Cys Tyr Ser Ser Val Thr Ala Pro Lys Met Ile 65 70 75 80

Page 3231

069269_0225_SL.TXT

Val Asp Leu Leu Ala 85 Lys Ser Lys Thr Ile Ser Tyr Val Gly Cys Met 90 95 Leu Gln Leu Phe Gly Val His Phe Phe Gly Cys Thr Glu Ile Phe Ile 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Ile Met Gly Cys Asp Arg Cys Asn Lys Met Leu Leu 130 135 140 Gly Thr Trp Ile Gly Gly Phe Leu His Ser Ile Ile Gln Val Ala Leu 145 150 155 160 Val Val Pro Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Ile His Pro Val Leu Lys Leu Ala Cys Thr Asp Thr Tyr Ile 180 185 190 Val Gly Val Val Val Thr Ala Asn Ser Gly Thr Ile Ala Leu Gly Ser 195 200 205 Phe Val Ile Leu Ile Ile Ser Tyr Thr Ile Ile Leu Val Ser Leu Arg 210 215 220 Lys His Ser Ala Glu Ser Arg Leu Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Ile Ala Val Val Ile Ile Phe Phe Gly Pro Cys Thr Phe Met Tyr 245 250 255 Met Arg Pro Asp Thr Thr Phe Ser Glu Asp Lys Met Val Ala Val Phe 260 265 270 Tyr Thr Ile Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285

Page 3232

069269_0225_SL.TXT

Asn Ala Glu Val Lys Asn Ala Met Lys Arg Leu Trp Gly Arg Lys Val 290 295 300

Phe Pro Glu Ala Asn Gly Lys

305 310 <210> 2903 <211> 932 <212> DNA <213> Felis catus <400> 2903 tcattttttg ttttctgagg taattttgag atgccatagc tttctcatgg catttttcac 60 ttctacattt ctcagtgtgt agatgagtgg gttgagaaat ggtgtcccaa tagtataaaa 120 tacggccacc aacttatcca tggggaaagt ggttgggggg cgtgtataaa taaatataca 180 tggaccaaag aataagacta ctacaatgat gtgggaagtg caagtagaga gagctttttc 240 ctcccttctg cgctgtggtt tctcagcgaa tgcaagatga caatgtatga gatcatcagt 300 atcacaaaac tgcttgagca aatggccccg ctgttagaca ccaacagcgt gttgatcacg 360 taagtgtcca tgcaagcaag tttcagcaag ggctgcaaat cacagcagta atgatcaatc 420 aaattgggtc cacagaaagg caatctcaac gccaggataa tctgggctat agaatgtata 480 aaagacccta tccatgcaag aacaatcagg atggtgcaga cctgccggct catgatggtt 540 gggtaacgta agggcttaca gatggccacg tagcgatcaa cagccatgag gatgaggaca 600 aagatctcca tgcagccaaa taaatgtagt gaaaagactt gagtcataca ctcattgtaa 660 gagatgattt tttttgcaga gagtgcatcc acaattagtc tgggggctgt agaagttgaa 720 aaacaggaat cagcaaggga caaataaaat aggaaaaagt acatggggct ctcaagtgtc 780 cggctggact tgatggtcac aataataagc aaattcccta ccacggttcc cacataaaaa 840 atgaagaaga ttacaaatac cactttctgt ctcataggat cttgggtcaa tcctaatagt 900 ataaactcag ttacgctgtt attttgctgc at 932 <210> 2904 <211> 243 <212> PRT

Page 3233

069269_0225_SL.TXT <213> Felis catus <400> 2904

Met 1 Gln Gln Asn Asn 5 Ser Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Gln Asp Pro Met Arg Gln Lys Val Val Phe Val Ile Phe Phe Ile Phe 20 25 30 Tyr Val Gly Thr Val Val Gly Asn Leu Leu Ile Ile Val Thr Ile Lys 35 40 45 Ser Ser Arg Thr Leu Glu Ser Pro Met Tyr Phe Phe Leu Phe Tyr Leu 50 55 60 Ser Leu Ala Asp Ser Cys Phe Ser Thr Ser Thr Ala Pro Arg Leu Ile 65 70 75 80 Val Asp Ala Leu Ser Ala Lys Lys Ile Ile Ser Tyr Asn Glu Cys Met 85 90 95 Thr Gln Val Phe Ser Leu His Leu Phe Gly Cys Met Glu Ile Phe Val 100 105 110 Leu Ile Leu Met Ala Val Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Pro Thr Ile Met Ser Arg Gln Val Cys Thr Ile Leu Ile Val 130 135 140 Leu Ala Trp Ile Gly Ser Phe Ile His Ser Ile Ala Gln Ile Ile Leu 145 150 155 160 Ala Leu Arg Leu Pro Phe Cys Gly Pro Asn Leu Ile Asp His Tyr Cys 165 170 175 Cys Asp Leu Gln Pro Leu Leu Lys Leu Ala Cys Met Asp Thr Tyr Val 180 185 190 Ile Asn Thr Leu Leu Val Ser Asn Ser Gly Ala Ile Cys Ser Ser Ser

Page 3234

0 6926 9_02 25_S L.TX T 195 200 205 Phe Val Ile Leu Met Ile Ser Tyr Ile Val Ile Leu His Ser Leu Arg 210 215 220 Asn His Ser Ala Glu Gly Arg Lys Lys Leu Ser Leu Leu Ala Leu Pro 225 230 235 240

Thr Ser Leu <210> 2905 <211> 893 <212> DNA <213> Felis catus <400> 2905

atggagagtc agaggaatgt ctcagaattc attcttttgg gactttcgta tgaccatcgc 60 acgcaaatat tttgctttgt gttcttctta ttctgttatg ctgctctctt ggtaggaaac 120 cttctgatcc ttatctctat tcgatgcagc cctcttttcc accaaccaat gtactatttc 180 ctcagccact tatcctgtat ggacatctgc ttcacctcta gcattacacc caaattcatt 240 gctgacctcc tagtgggaag aaaagccatc tcctatggta actgtatgtt acaagtcttt 300 accatgcact tcttcggaat gattgaagtc ttaatcctca ccgtcatggc ctttgatcgc 360 tacgctgcca tctgcaaacc tctccactac ctgcttgtca tgaacagagc aaggtgcaat 420 ctcctcgtct tagctgcttg ggctggtggg gccgcgcact cctttcctca gttttttctg 480 gtaatcaggt tgcccttctg tggtcctaat gagattgatc actatttttg cgacattttt 540 cctttgctaa aagttgcctg tgctgacacg tatgtcaccg gtgtcctttt ggttgccaat 600 tcaggaatgg ttaccttagt ggcatttgtg gtcttgtttt tttcttatgt cattatatta 660 ttcactttaa gaaatcattc agccaaagga aggcgcaaag ccctctctac ctgtgggtcg 720 catatcactg tgatagtttt attttttggg ccttcaatct ttgcctacct tcggcctcca 780 accactttcc ctgaggataa ggtatttgct ctgttttaca ccatcattgc tccgatgttc 840 aatcccttca tatacactct gaggaactca gagatgaaaa acgccatgag aaa 893

Page 3235

069269_0225_SL.TXT <210> 2906 <211> 298 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (298)..(298) <223> Any amino acid

<400> 2906 Asn Val Ser Glu Phe Ile Leu Leu Gly Leu Ser Met Glu 1 Ser Gln Arg 5 10 15 Tyr Asp His Arg Thr Gln Ile Phe Cys Phe Val Phe Phe Leu Phe Cys 20 25 30 Tyr Ala Ala Leu Leu Val Gly Asn Leu Leu Ile Leu Ile Ser Ile Arg 35 40 45 Cys Ser Pro Leu Phe His Gln Pro Met Tyr Tyr Phe Leu Ser His Leu 50 55 60 Ser Cys Met Asp Ile Cys Phe Thr Ser Ser Ile Thr Pro Lys Phe Ile 65 70 75 80 Ala Asp Leu Leu Val Gly Arg Lys Ala Ile Ser Tyr Gly Asn Cys Met 85 90 95 Leu Gln Val Phe Thr Met His Phe Phe Gly Met Ile Glu Val Leu Ile 100 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Leu Val Met Asn Arg Ala Arg Cys Asn Leu Leu Val Leu 130 135 140 Ala Ala Trp Ala Gly Gly Ala Ala His Ser Phe Pro Gln Phe Phe Leu 145 150 155 160

Page 3236

Val Ile Arg Leu Pro 165 Phe Cys 069269_0225_SL.TXT Gly Pro Asn Glu Ile Asp 170 His Tyr 175 Phe Cys Asp Ile Phe Pro Leu Leu Lys Val Ala Cys Ala Asp Thr Tyr Val 180 185 190 Thr Gly Val Leu Leu Val Ala Asn Ser Gly Met Val Thr Leu Val Ala 195 200 205 Phe Val Val Leu Phe Phe Ser Tyr Val Ile Ile Leu Phe Thr Leu Arg 210 215 220 Asn His Ser Ala Lys Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240 His Ile Thr Val Ile Val Leu Phe Phe Gly Pro Ser Ile Phe Ala Tyr 245 250 255 Leu Arg Pro Pro Thr Thr Phe Pro Glu Asp Lys Val Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Phe Ile Tyr Thr Leu Arg 275 280 285 Asn Ser Glu Met Lys Asn Ala Met Arg Xaa

290 295 <210> 2907 <211> 934 <212> DNA <213> Felis catus <400> 2907 atgaaaagcc agagaaacat ctcagaattc attcttctgg gactttccta cgaccagaac atacaagtat tttgctttgt cctcttctta gtctgttacg tcgccttgtt ggcaggaaac ctgctgatcc tcgtctccgt tcgatgcagc cctctttttc accaacccat gtactatttc ctcagccact tatccttaat agacatctgc tatacctcta ctgttacacc caagttaatt gctgacctgc tggtggaaag aaaaaccatt tcctatagta actgcatgtt acaggtgttt

120

180

240

300

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069269_0225_SL.TXT

acaatgcact tctttggagg caccgagatc ttcgttctta ccgccatggc ctttgatcgc 360 tatgctgcca tctgcaaacc tctccactac gtgattgtca tgaacaggac aagatgcaat 420 ctgctagtcg tagctgcctg ggctggtggg gccgtccatg ccttccctct cttttctacc 480 gcgattggtt tgcccttctg tggtcctaat gaaattgatc actacttttg tgatattttt 540 cctttgctaa aagttgcctg caccgacacc tatgtcactg gtatccttgt gattgccttt 600 tcaggtctgg tcgccttagt tacctttatt gtcttatttg tttcttatgg tattatctta 660 ttcactttaa gaaatctctc agctgaggga agacgcaaag ccctctccac ctgttggtct 720 catatcactg tggtcgtctt attttttgga ccagtaatct ttatctacct taggccgcct 780 actacttttc ctgaggacaa aatatttgct ctattttaca cgatcattgc tcctatgttt 840 aatcccttaa tctacactct gagaaactca gagatgaaaa acatgatgag gaaagtttgg 900 tgtcacacat tattttcaaa ggaaacacac aatt 934

<210> 2908 <211> 312 <212> PRT <213> Felis catus <220>

<221> MOD RES

<222> (312)..(312) Ile Ser Glu Phe 10 Ile Leu Leu Gly Leu 15 Ser <223> Any amino <400> 2908 acid Arg Asn 5 Met 1 Lys Ser Gln Tyr Asp Gln Asn 20 Ile Gln Val Phe Cys 25 Phe Val Leu Phe Leu 30 Val Cys Tyr Val Ala Leu 35 Leu Ala Gly Asn 40 Leu Leu Ile Leu Val 45 Ser Val Arg Cys Ser Pro Leu 50 Phe His Gln 55 Pro Met Tyr Tyr Phe 60 Leu Ser His Leu Ser Leu Ile Asp Ile Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Ile

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Ala Asp Leu Leu Val Glu Arg Lys Thr Ile Ser Tyr Ser Asn Cys Met 85 90 95 Leu Gln Val Phe Thr Met His Phe Phe Gly Gly Thr Glu Ile Phe Val 100 105 110 Leu Thr Ala Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Val Ile Val Met Asn Arg Thr Arg Cys Asn Leu Leu Val Val 130 135 140 Ala Ala Trp Ala Gly Gly Ala Val His Ala Phe Pro Leu Phe Ser Thr 145 150 155 160 Ala Ile Gly Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Ile Phe Pro Leu Leu Lys Val Ala Cys Thr Asp Thr Tyr Val 180 185 190 Thr Gly Ile Leu Val Ile Ala Phe Ser Gly Leu Val Ala Leu Val Thr 195 200 205 Phe Ile Val Leu Phe Val Ser Tyr Gly Ile Ile Leu Phe Thr Leu Arg 210 215 220 Asn Leu Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Trp Ser 225 230 235 240 His Ile Thr Val Val Val Leu Phe Phe Gly Pro Val Ile Phe Ile Tyr 245 250 255 Leu Arg Pro Pro Thr Thr Phe Pro Glu Asp Lys Ile Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg

Page 3239

275 069269_0225_SL.TXT 280 285 Asn Ser Glu Met Lys Asn Met Met Arg Lys Val Trp Cys His Thr Leu 290 295 300 Phe Ser Lys Glu Thr His Asn Xaa 305 310

<210> 2909 <211> 930 <212> DNA <213> Felis catus <400> 2909

ttatttctcc cctgaaatag ctttcctact acacaatttc ctaatggcat ttttcatctg 60 gtcatttctc aaggtataga ttagaggatt taacatggga gttatcatag tgtagaacac 120 tgccactgct ttgtcgatag ataaagtagc tgcgggtctc atgtactcaa atatgcaagg 180 cacaaagaaa aagacaacca ctgtgatgtg agagacacag gtggagaggg ctttgcgcct 240 tgcctccaag ctgtggttcc ttagggagcg cagaatgacc acataggaga ccatcaagag 300 gaggaagttt aagacacaga tgaaaccact gttggcagca acgaagagcc ctagagtgtg 360 ggtatctgtg caggcaagtt tgagcaaagg gttcagatca cacataaagt ggtctatgac 420 gttagggcca cagaagggta atgggatgat aaagaggatc tgtatgattg catgaagaaa 480 gccccccacc cacaccactc ccattaacag gccacacacc cgtcgattca tgatggtcat 540 gtagtgcaat ggtttgcaga tggccacata gcggtcatag gccatcaccg taagcaggat 600 gacatcagca cctccaaaga agtgttcccc aaagatttgg gtcatacatg cattgaatag 660 ggtggtcttc ttttcacgga gtgaatctat gatcaatttg gggttattga ccgaggaata 720 gcaagcatca atgaaggaga gataggccaa gaaaaagtac atgggggacc ccaataatgg 780 gctggcagtg atagtgacca gagtgagcac gtttcctacc atagagacga tgtagatggc 840 caaaaacaca acaaatatga ctttctgcat ctttggattc tctgtgagcc ccagtagaac 900 aaactccgtc acgttgttcc tattctccat 930

<210> 2910 <211> 309

Page 3240

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 2910 Leu Gly Leu Thr 15 Met 1 Glu Asn Arg Asn Asn Val Thr 5 Glu Phe 10 Val Leu Glu Asn Pro Lys Met Gln Lys Val Ile Phe Val Val Phe Leu Ala Ile 20 25 30 Tyr Ile Val Ser Met Val Gly Asn Val Leu Thr Leu Val Thr Ile Thr 35 40 45 Ala Ser Pro Leu Leu Gly Ser Pro Met Tyr Phe Phe Leu Ala Tyr Leu 50 55 60 Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Asn Asn Pro Lys Leu Ile 65 70 75 80 Ile Asp Ser Leu Arg Glu Lys Lys Thr Thr Leu Phe Asn Ala Cys Met 85 90 95 Thr Gln Ile Phe Gly Glu His Phe Phe Gly Gly Ala Asp Val Ile Leu 100 105 110 Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Met Thr Ile Met Asn Arg Arg Val Cys Gly Leu Leu Met Gly 130 135 140 Val Val Trp Val Gly Gly Phe Leu His Ala Ile Ile Gln Ile Leu Phe 145 150 155 160 Ile Ile Pro Leu Pro Phe Cys Gly Pro Asn Val Ile Asp His Phe Met 165 170 175 Cys Asp Leu Asn Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr His Thr 180 185 190

Page 3241

Leu Gly Leu 195 Phe Val Ala Ala 069269_0225_SL.TXT Asn Ser Gly Phe Ile Cys 200 205 Val Leu Asn Phe Leu Leu Leu Met Val Ser Tyr Val Val Ile Leu Arg Ser Leu Arg 210 215 220 Asn His Ser Leu Glu Ala Arg Arg Lys Ala Leu Ser Thr Cys Val Ser 225 230 235 240 His Ile Thr Val Val Val Phe Phe Phe Val Pro Cys Ile Phe Glu Tyr 245 250 255 Met Arg Pro Ala Ala Thr Leu Ser Ile Asp Lys Ala Val Ala Val Phe 260 265 270 Tyr Thr Met Ile Thr Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Asp Gln Met Lys Asn Ala Ile Arg Lys Leu Cys Ser Arg Lys Ala 290 295 300 Ile Ser Gly Glu Lys

305 <210> 2911 <211> 930 <212> DNA <213> Felis catus <400> 2911 atggaaaatc agaacaatgt cacagaattt gttttcatgg gtctgtgggg aaataagcaa atggagctcc tgttcttttt ctggttcctg ctctgttacc tggctgtctt aatgggcaac gtcatcatct tgctcacaat cacctgcagc catctaatcg aacagccgat gtactacttt ctctgtcacc tttccctcat ggatctctgc tacacctcca ccgtggtccc caggctaatc agggacttag gcgccgcaag aagaaacatc tcctataaca attgtatgac ccagctcttc gctgcccact tgctggcggg tgtggagata ttcatcttgg tgtccatggc ttttgaccgc tatgttgcca ttgtcaagcc cctgcactac acggtcctca tgaaccggca gaggtgtaac

120

180

240

300

360

420

Page 3242

069269_0225_SL.TXT

atgttgatct tcacggcctg ggctgtgggt ttttggcact ccattgctct gttgctcatg 480 gtactcaact tacctttctg tggtcctaat cagatagatc actacgtatg tgatgtgaag 540 cctcttttga aactggtgtg cagagacatt catgttgtta gtatcttagt gattgctaat 600 tcagggatgg tggtggttgt catttttctt gtcctggtgg cttcttacat actcatatta 660 tataatctta ggacccgctc ctccgcaggg cgacgcaaag ctctctccac ctgcagctct 720 cacgtaatgg tggtggtttt attctttgtg ccctgtatct atacttacgt tttacctgca 780 gggagtgaga acaaggataa ggaaatatcc gtgttttaca ctgtgattgc ccctatgctg 840 aatcctctca tctataccct gagaaacacg gagatgaaaa ccgccatgca gaaggtatgg 900 tctaaaatgg cacattcaga atgcaagtaa 930

<210> 2912 <211> 309 <212> PRT <213> Felis catus

<400> 2912 Asn Val Thr Glu Phe Val Phe Met Gly Leu Trp Met Glu 1 Asn Gln Asn 5 10 15 Gly Asn Lys Gln Met Glu Leu Leu Phe Phe Phe Trp Phe Leu Leu Cys 20 25 30 Tyr Leu Ala Val Leu Met Gly Asn Val Ile Ile Leu Leu Thr Ile Thr 35 40 45 Cys Ser His Leu Ile Glu Gln Pro Met Tyr Tyr Phe Leu Cys His Leu 50 55 60 Ser Leu Met Asp Leu Cys Tyr Thr Ser Thr Val Val Pro Arg Leu Ile 65 70 75 80 Arg Asp Leu Gly Ala Ala Arg Arg Asn Ile Ser Tyr Asn Asn Cys Met 85 90 95 Thr Gln Leu Phe Ala Ala His Leu Leu Ala Gly Val Glu Ile Phe Ile 100 105 110

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069269_0225_SL.TXT

Leu Val Ser 115 Met Ala Phe Asp Arg Tyr Val Ala Ile Val Lys Pro Leu 120 125 His Tyr Thr Val Leu Met Asn Arg Gln Arg Cys Asn Met Leu Ile Phe 130 135 140 Thr Ala Trp Ala Val Gly Phe Trp His Ser Ile Ala Leu Leu Leu Met 145 150 155 160 Val Leu Asn Leu Pro Phe Cys Gly Pro Asn Gln Ile Asp His Tyr Val 165 170 175 Cys Asp Val Lys Pro Leu Leu Lys Leu Val Cys Arg Asp Ile His Val 180 185 190 Val Ser Ile Leu Val Ile Ala Asn Ser Gly Met Val Val Val Val Ile 195 200 205 Phe Leu Val Leu Val Ala Ser Tyr Ile Leu Ile Leu Tyr Asn Leu Arg 210 215 220 Thr Arg Ser Ser Ala Gly Arg Arg Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Val Met Val Val Val Leu Phe Phe Val Pro Cys Ile Tyr Thr Tyr 245 250 255 Val Leu Pro Ala Gly Ser Glu Asn Lys Asp Lys Glu Ile Ser Val Phe 260 265 270 Tyr Thr Val Ile Ala Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Thr Glu Met Lys Thr Ala Met Gln Lys Val Trp Ser Lys Met Ala 290 295 300 His Ser Glu Cys Lys

305

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069269_0225_SL.TXT <210> 2913 <211> 936 <212> DNA <213> Felis catus <400> 2913

atggagagcc agagaaacac ctcagaattc gttcttctag gactttcgta tgaccagaac 60 gtacaaatat tttgctttgt gctcttctta ttctgttatg ttgccctgtt ggcaggaaac 120 ctgctgatcc tcgtctccat tcgatgcagc cctcttttcc accaacccat gtactatttc 180 ctcagccact tatcctgtat ggacatctgc tatacctcta gtgttacacc caaattcatt 240 gctgacctac gaggggggac aaaaacgatc tcctacggta attgcatgtt ccaggtcttt 300 gctatgcact tctttgggag tactgaggtc tttgtcctca cagtcatggc ctttgatcgc 360 tacgtggcta tctgtaaacc tctccactac ctgcttatca tgaacaggac aagatgcaat 420 cttctagtct tggctgcttg ggctggtggg gctctccatt ctcttcctca attatcgatg 480 accatccagt tgccattttg tggacctaat gagattgatc actatttttg tgacatcttg 540 cctttgttga aagttgcctg tactgatacc tacatcactg gtgtccttgt ggttgccaat 600 tcaggtctgg tcgctttagt gaccttcgtt gtcttatttg tttcttatgt cattatattg 660 tttagtctaa gacatcgttc ggccgaggga agacacaaag ccctctctac ctgtgggtct 720 catattactg tggtcatctt attttttgga ccttcaatct ttgcctacct tcgacctccg 780 accacgttcc cccaggacaa aatatttgct ctattttaca ccatcatcgc tcctatgttc 840 aatcccttaa tctacaccct gagaaataca gagatgaaaa gcgcgatgag aaaagtttgg 900 tgtcaaacat tattttcgaa ggaagcacac aattaa 936

<210> 2914 <211> 311 <212> PRT <213> Felis catus <400> 2914

Met Glu Ser Gln Arg Asn Thr Ser Glu Phe Val Leu Leu Gly Leu Ser

1 5 10 15

Tyr Asp Gln Asn Val Gln Ile Phe Cys Phe Val Leu Phe Leu Phe Cys

20 25 30

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Tyr Val Ala 35 Leu Leu Ala Gly Asn Leu Leu Ile Leu Val Ser Ile Arg 40 45 Cys Ser Pro Leu Phe His Gln Pro Met Tyr Tyr Phe Leu Ser His Leu 50 55 60 Ser Cys Met Asp Ile Cys Tyr Thr Ser Ser Val Thr Pro Lys Phe Ile 65 70 75 80 Ala Asp Leu Arg Gly Gly Thr Lys Thr Ile Ser Tyr Gly Asn Cys Met 85 90 95 Phe Gln Val Phe Ala Met His Phe Phe Gly Ser Thr Glu Val Phe Val 100 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Leu Ile Met Asn Arg Thr Arg Cys Asn Leu Leu Val Leu 130 135 140 Ala Ala Trp Ala Gly Gly Ala Leu His Ser Leu Pro Gln Leu Ser Met 145 150 155 160 Thr Ile Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Ile Leu Pro Leu Leu Lys Val Ala Cys Thr Asp Thr Tyr Ile 180 185 190 Thr Gly Val Leu Val Val Ala Asn Ser Gly Leu Val Ala Leu Val Thr 195 200 205 Phe Val Val Leu Phe Val Ser Tyr Val Ile Ile Leu Phe Ser Leu Arg 210 215 220 His Arg Ser Ala Glu Gly Arg His Lys Ala Leu Ser Thr Cys Gly Ser 225 230 235 240

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His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Ser Ile Phe Ala Tyr 245 250 255 Leu Arg Pro Pro Thr Thr Phe Pro Gln Asp Lys Ile Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Thr Glu Met Lys Ser Ala Met Arg Lys Val Trp Cys Gln Thr Leu 290 295 300 Phe Ser Lys Glu Ala His Asn

305 310 <210> 2915 <211> 767 <212> DNA <213> Felis catus <400> 2915 aatcacagct gtcatcttat ccatggggaa ggtggttgca gggcgtgcat atataaatat gcaaggaccg aagaacaaaa tgaccacaat gatgtgggag acacaggtgg agagggcttt tctcctccct tcagcactgt ggtttctcag agaatacaag atattaacat aggagcacat cagcatgaca aaactcaggg tacaaatggc cccgctattg gacaccaaga gtagattgat tacgtaagtg tctgtacagg cgagtcacaa caatggctgc aagtcacaaa aatagtgatc gatcacattg ggaccacaga agggtaaact caaggccaga aaaacctaag ctaaagaatg tacacaggac cccacccagg ccatagccac cagcacagca cagacccgtc gactcatgat ggttgtgtag tgcaggggct tacagatggc cacatagcgg tcagcggcca tgaggataag aatgaagatc tccaggcagc caaagaaatg gaatgggaag acctgtatca tgcactcact gaaagagata gtggtctttt tttaaagggc atccacaatc attccagggg ctacggaagt acagaagcag gtgtcagata aggatcggtg ggctaggaag tagcacacgg gactcctgag ttccccgggg ggccttgaca gtggtaatga tcagaacgtt acccagcaac atgcccgaat

120

180

240

300

360

420

480

540

600

660

720

Page 3247

069269_0225_SL.TXT agagaagcaa gacaatgaca aacgctgttt tcctcctaac aggatcc 767 <210> 2916 <211> 77 <212> PRT <213> Felis catus

<400> 2916 Asn His Ser Cys 1 His 5 Leu Ile His Gly Glu Gly Gly Cys Arg Ala Cys 10 15 Ile Tyr Lys Tyr Ala Arg Thr Glu Glu Gln Asn Asp His Asn Asp Val 20 25 30 Gly Asp Thr Gly Gly Glu Gly Phe Ser Pro Pro Phe Ser Thr Val Val 35 40 45 Ser Gln Arg Ile Gln Asp Ile Asn Ile Gly Ala His Gln His Asp Lys 50 55 60 Thr Gln Gly Thr Asn Gly Pro Ala Ile Gly His Gln Glu 65 70 75

<210> 2917 <211> 929 <212> DNA <213> Felis catus <400> 2917

atggatcaaa gcaataatgt cactgtattt attctcttgg gactttccaa aaacaagaac 60 attgaaatcc tttgttttgt gttattttta ttttgctaca ttgctatttg gataggaaac 120 tcactcgtaa taatttccat catgggcagt cagctaattg agcaacccat gtattttttc 180 cttaattacc tctcactctc cgacctttgc tacacatcca ccgtgacacc caaactaatg 240 actgacttgt tggcagagag gaagaccatt tcctacagta gctgcatgac acaactcttt 300 agcacacatt tatttggagg catcgagatc ttcatcctca cggggatggc ctatgaccgc 360 tacgtggcca tctgcaggcc cctgcactac acggtcatca tgagcagaca gaggtgtaac 420 acaattatca cagcctgctg tactgggggg tttgtacatt ctgccagcca gttccttctc 480 accatcttct tacccttctg tggccccaat gagatagatc actacttctg cgacgtgtac 540

Page 3248

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cctttactga aactagcctg ttctaataca cacctcatag gtctcctagt cattgccaat 600 tcaggcctaa ttgctttggt gaccttcgtc gtgctgatgt tgtcttactt ttttatactg 660 tgcagtgtca gggcttactc cgcagagagt cgcagcaagg ctctttccac ctgcagtgct 720 cacatcacag ttgtggcttt gttttttgca cctgcactct tcatctatat tagaccagcc 780 acaacatttc cagaagacaa agtgtttgct cttttctata ccatcattgc ccccatgttc 840 aaccctctga tctacacgtt gagaaacaca gagatgaaga aagccatgaa gaaagtgtgg 900 tgtcgtcata tactcttgga aggaaagta 929

<210> 2918 <211> 310 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (310)..(310) <223> Any amino acid <400> 2918

Met Asp Gln Ser Asn Asn Val Thr Val Phe Ile Leu Leu Gly Leu Ser 1 5 10 15 Lys Asn Lys Asn Ile Glu Ile Leu Cys Phe Val Leu Phe Leu Phe Cys 20 25 30 Tyr Ile Ala Ile Trp Ile Gly Asn Ser Leu Val Ile Ile Ser Ile Met 35 40 45 Gly Ser Gln Leu Ile Glu Gln Pro Met Tyr Phe Phe Leu Asn Tyr Leu 50 55 60 Ser Leu Ser Asp Leu Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Met 65 70 75 80 Thr Asp Leu Leu Ala Glu Arg Lys Thr Ile Ser Tyr Ser Ser Cys Met 85 90 95

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Thr Gln Leu Phe 100 Ser Thr His Leu Phe Gly Gly Ile Glu Ile Phe Ile 105 110 Leu Thr Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125 His Tyr Thr Val Ile Met Ser Arg Gln Arg Cys Asn Thr Ile Ile Thr 130 135 140 Ala Cys Cys Thr Gly Gly Phe Val His Ser Ala Ser Gln Phe Leu Leu 145 150 155 160 Thr Ile Phe Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Val Tyr Pro Leu Leu Lys Leu Ala Cys Ser Asn Thr His Leu 180 185 190 Ile Gly Leu Leu Val Ile Ala Asn Ser Gly Leu Ile Ala Leu Val Thr 195 200 205 Phe Val Val Leu Met Leu Ser Tyr Phe Phe Ile Leu Cys Ser Val Arg 210 215 220 Ala Tyr Ser Ala Glu Ser Arg Ser Lys Ala Leu Ser Thr Cys Ser Ala 225 230 235 240 His Ile Thr Val Val Ala Leu Phe Phe Ala Pro Ala Leu Phe Ile Tyr 245 250 255 Ile Arg Pro Ala Thr Thr Phe Pro Glu Asp Lys Val Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Thr Glu Met Lys Lys Ala Met Lys Lys Val Trp Cys Arg His Ile 290 295 300

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Leu Leu Glu Gly Lys Xaa 305 310 <210> 2919 <211> 956 <212> DNA <213> Felis catus <400> 2919

atgggaagtc agaggaacat ctcagaattc attcttttgg gactttccta taaccagaac 60 atacaaattt tttgctttgt attcttcttg ttttgttatg tttccatttt ggtgggaaat 120 gtcttaattc tcgtctccat tcgatgcagt gccctttttt accaaccaat gtactatttc 180 ctcggtcact tatcctttat ggacatttgc tacacctcct ctgtgacacc caaactgata 240 ggtgatctgc tgctgaccag aaaaaccatc tcttatggta attgcatgtt acaggtcttt 300 tccttgcact ttttgggaat gattgaaatc ttcatcctta cagtcatggc ctttgatcgc 360 tacgctgcca tctgcaaacc tctccactac ctgcttatca tgaatagagc aaggtgcaat 420 ctcctagtct tggctgcttg ggctggtggg gccgtccatt ctttttctca gttttctatg 480 atattccagt tgcctttctg tggccccaac gaaatcaatc actactattg tgatatcttc 540 cctttgctga aagttgcttg tactgatacc tacatcactg gtgtccttgt ggttgccaat 600 tcaggtctgg tcgctttagt gacctttgtt ctcttgtttg ggtcttatgt tgtcatatta 660 ttcactttaa gacatcagtc ggctgaagga agacgcaaag ccctctccac ctgtgggtct 720 catatcactg tggtcatctt attttttggg ccttcaatct ttgcctacct tcgacctccg 780 accacgttcc ccgaggacaa gatattcgct ctattttaca ccatcatcgc tcctatgttc 840 aatcccttaa tctacaccct gagaaataca gagatgaaaa gcgtgatgag aaaagtttgg 900 tttcaaatga tattttcagg agaaaaacac aattgatttg tcctattcaa tatgct 956

<210> 2920 <211> 311 <212> PRT <213> Felis catus <400> 2920

Met Gly Ser Gln Arg Asn Ile Ser Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15

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Tyr Asn Gln Asn 20 Ile Gln Ile Phe Cys Phe Val Phe Phe Leu Phe Cys 25 30 Tyr Val Ser Ile Leu Val Gly Asn Val Leu Ile Leu Val Ser Ile Arg 35 40 45 Cys Ser Ala Leu Phe Tyr Gln Pro Met Tyr Tyr Phe Leu Gly His Leu 50 55 60 Ser Phe Met Asp Ile Cys Tyr Thr Ser Ser Val Thr Pro Lys Leu Ile 65 70 75 80 Gly Asp Leu Leu Leu Thr Arg Lys Thr Ile Ser Tyr Gly Asn Cys Met 85 90 95 Leu Gln Val Phe Ser Leu His Phe Leu Gly Met Ile Glu Ile Phe Ile 100 105 110 Leu Thr Val Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Leu Leu Ile Met Asn Arg Ala Arg Cys Asn Leu Leu Val Leu 130 135 140 Ala Ala Trp Ala Gly Gly Ala Val His Ser Phe Ser Gln Phe Ser Met 145 150 155 160 Ile Phe Gln Leu Pro Phe Cys Gly Pro Asn Glu Ile Asn His Tyr Tyr 165 170 175 Cys Asp Ile Phe Pro Leu Leu Lys Val Ala Cys Thr Asp Thr Tyr Ile 180 185 190 Thr Gly Val Leu Val Val Ala Asn Ser Gly Leu Val Ala Leu Val Thr 195 200 205 Phe Val Leu Leu Phe Gly Ser Tyr Val Val Ile Leu Phe Thr Leu Arg 210 215 220

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His Gln 225 Ser Ala Glu Gly Arg Arg Lys Ala Leu Ser Thr Cys Gly Ser 230 235 240 His Ile Thr Val Val Ile Leu Phe Phe Gly Pro Ser Ile Phe Ala Tyr 245 250 255 Leu Arg Pro Pro Thr Thr Phe Pro Glu Asp Lys Ile Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Thr Glu Met Lys Ser Val Met Arg Lys Val Trp Phe Gln Met Ile 290 295 300 Phe Ser Gly Glu Lys His Asn

305 310 <210> 2921 <211> 982 <212> DNA <213> Felis catus <400> 2921

atgggaaata gaaacaacgt caccgtgttt attctcttgg gactctctca aaacaagaac 60 gttgaaatcc tctgctttat attattttca ttttgctacg ttgccatttg gatgggcaat 120 ctgctcgtaa tgatttccat cacatgcagt ccactcatta accaacctat gtatttcttc 180 cttaattgtc tctcactttc tgaccttagc tacacatcaa cagtgacacc caaacttctg 240 attgatttgc tggcagagag gaagaccatt tcctacagta actgcatgac acagctcttt 300 atcctccact ttctcggagg catcgagatc ttcatcctca cggggatggc ctatgaccgc 360 tatgtggcca tctgcaggcc cctgcactac acggtcatca tgagcagaca gaggtgcaac 420 acaatcatca cagcctgctg cacgggggca tttctacact ctgccagcca gttccttctc 480 accatcttct tacccttctg tggccccaat gagatagatc actacttctg cgacgtgtat 540 cctctcctga aactggcctg cactgacacg tacagaattg gcgtcttggt aattgtcgat 600 tcaggtctga ttgccttact ggcttttgtg attttgatgg cgtcctattt tctgattctg 660

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tacaccatca gggcttaccc tgcagagagc cgcgccaaag ctctgtccac ctgtagttcc 720 catgtcacag ttgtgattct gttctttgcg cctgttctct tcatttatat tcgaccagcc 780 gcgacacttc cagaagacaa agtgtttgct ctcttctaca ccatcattgc ccccatgttc 840 aaccctctga tctacacgct gagaaacatg gagatgaagg atgccatgaa gaaaatttgg 900 tttcgttatt tgttcttgga agggaagtaa cttctacgca aagcgttcta gaatttcacg 960 ttagagctcc atcctgaccc ta 982

<210> 2922 <211> 309 <212> PRT <213> Felis catus

<400> 2922 Asn Val Thr Val Phe Ile Leu Leu Gly Leu Ser Met 1 Gly Asn Arg Asn 5 10 15 Gln Asn Lys Asn Val Glu Ile Leu Cys Phe Ile Leu Phe Ser Phe Cys 20 25 30 Tyr Val Ala Ile Trp Met Gly Asn Leu Leu Val Met Ile Ser Ile Thr 35 40 45 Cys Ser Pro Leu Ile Asn Gln Pro Met Tyr Phe Phe Leu Asn Cys Leu 50 55 60 Ser Leu Ser Asp Leu Ser Tyr Thr Ser Thr Val Thr Pro Lys Leu Leu 65 70 75 80 Ile Asp Leu Leu Ala Glu Arg Lys Thr Ile Ser Tyr Ser Asn Cys Met 85 90 95 Thr Gln Leu Phe Ile Leu His Phe Leu Gly Gly Ile Glu Ile Phe Ile 100 105 110 Leu Thr Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg Pro Leu 115 120 125

Page 3254

His Tyr 130 Thr Val Ile Met Ser 135 069269_0225_SL.TXT Arg Gln Arg Cys Asn Thr 140 Ile Ile Thr Ala Cys Cys Thr Gly Ala Phe Leu His Ser Ala Ser Gln Phe Leu Leu 145 150 155 160 Thr Ile Phe Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Val Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr Tyr Arg 180 185 190 Ile Gly Val Leu Val Ile Val Asp Ser Gly Leu Ile Ala Leu Leu Ala 195 200 205 Phe Val Ile Leu Met Ala Ser Tyr Phe Leu Ile Leu Tyr Thr Ile Arg 210 215 220 Ala Tyr Pro Ala Glu Ser Arg Ala Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Val Thr Val Val Ile Leu Phe Phe Ala Pro Val Leu Phe Ile Tyr 245 250 255 Ile Arg Pro Ala Ala Thr Leu Pro Glu Asp Lys Val Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Met Glu Met Lys Asp Ala Met Lys Lys Ile Trp Phe Arg Tyr Leu 290 295 300 Phe Leu Glu Gly Lys

<210> 2923 <211> 935 <212> DNA <213> Felis catus

305

Page 3255

069269_0225_SL.TXT <400> 2923 atggaaaata tgaacaacgt cactgaattt gttctgttgg gactttccca gaacaagaaa 60 attaaaaact tgtgctttct actattctta ttttgttaca tagctatttg gatgggaaac 120 ttgctcataa tgatttctat cacatgcagc ccgctaattg accaacccat gtatttcttc 180 cttaataacc ttgcgctctc agatctgtgt tatacgtcaa cagtgacacc caagctagtc 240 accgacttgc tggcagaaag taacatgatt tcttatacta gctgtatggc acagcttttt 300 gccatgcatt tctttggggg gattgaaatc tttatcctca cagcgatggc ctatgaccgc 360 tacgtggcca tctgcaagcc cctgcactat accatcatca tgaacaggca gaggtgttat 420 accatagtca ctgctagctg taccggggca tttctgcatt cttttttcca gtgtctcctt 480 accatcaatt tacctttctg tggccccaat gaaatagatc actacttctg tgatgtgtat 540 cctttgctga aactggcctg cacagacact taccgagttg ggatcctagt ggttgccaac 600 tcaggcatga tgggcttggt gacctttgtg gtcttggtgc tgtcttactt gttgatattg 660 tacaccatca gggcttaccc tgcagagagc cgcaccaaag cactttccac ctgtagttcc 720 cacatcacag ttgttgttct gttctttgtg cctgttctct tcatttacat tagaccaacc 780 acaactttcc cggaagacaa agtgtttgct ctcttctaca ccatcattgc ccccatgttt 840 aaccctctca tttacacatt cagaaacgtg gagatgaaga ctgccttgag aaaagtgtgg 900 tgccagaaac tatgttttat tggaaggcaa atcat 935 <210> 2924 <211> 312 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (312)..(312) <223> Any amino acid <400> 2924

Met Glu Asn Met Asn Asn Val Thr Glu Phe Val Leu Leu Gly Leu Ser

1 5 10 15

Gln Asn Lys Lys Ile Lys Asn Leu Cys Phe Leu Leu Phe Leu Phe Cys

Page 3256

069269_0225_SL.TXT 25 30

Tyr Ile Ala 35 Ile Trp Met Gly Asn Leu Leu Ile Met Ile Ser Ile Thr 40 45 Cys Ser Pro Leu Ile Asp Gln Pro Met Tyr Phe Phe Leu Asn Asn Leu 50 55 60 Ala Leu Ser Asp Leu Cys Tyr Thr Ser Thr Val Thr Pro Lys Leu Val 65 70 75 80 Thr Asp Leu Leu Ala Glu Ser Asn Met Ile Ser Tyr Thr Ser Cys Met 85 90 95 Ala Gln Leu Phe Ala Met His Phe Phe Gly Gly Ile Glu Ile Phe Ile 100 105 110 Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Thr Ile Ile Met Asn Arg Gln Arg Cys Tyr Thr Ile Val Thr 130 135 140 Ala Ser Cys Thr Gly Ala Phe Leu His Ser Phe Phe Gln Cys Leu Leu 145 150 155 160 Thr Ile Asn Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Val Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr Tyr Arg 180 185 190 Val Gly Ile Leu Val Val Ala Asn Ser Gly Met Met Gly Leu Val Thr 195 200 205 Phe Val Val Leu Val Leu Ser Tyr Leu Leu Ile Leu Tyr Thr Ile Arg 210 215 220 Ala Tyr Pro Ala Glu Ser Arg Thr Lys Ala Leu Ser Thr Cys Ser Ser

Page 3257

0 6926 9_02 25_S ;l.tx T 225 230 235 240 His Ile Thr Val Val Val Leu Phe Phe Val Pro Val Leu Phe Ile Tyr 245 250 255 Ile Arg Pro Thr Thr Thr Phe Pro Glu Asp Lys Val Phe Ala Leu Phe 260 265 270 Tyr Thr Ile Ile Ala Pro Met Phe Asn Pro Leu Ile Tyr Thr Phe Arg 275 280 285 Asn Val Glu Met Lys Thr Ala Leu Arg Lys Val Trp Cys Gln Lys Leu 290 295 300 Cys Phe Ile Gly Arg Gln Ile Xaa

305 310 <210> 2925 <211> 939 <212> DNA <213> Felis catus <400> 2925

tcaaatcatt gacttccctt tccaaaacct tgcaccgcac caaactttcc ttatggcatt 60 tttcatctct gtgtttctaa gtgtgtagat aagaggattg agcatgggga caataattgt 120 gtagaagagt gtgaacactt tatcttccgg taaagttgtg gcaggtcgaa tgtaaacaaa 180 gatgacaggt gcaaaaaaca ggatcacaac cgtgatgtgg gagctgcagg tggaaagggc 240 cttgtggcgg ttctctgcag aatatgctct cacattgcat aatatcatga agtaggaggc 300 catcaaaacc acgaagatcc ccagtcccat caggccggaa ttggcaatga ctaagaaacc 360 aattttgtgt gtatcagtgc aggccagttt caacaaagga tatacatcgc agaaatagtg 420 atctatttca ttggggccac agaatggcag aaaaattgca agaagaaaca ggccaatgga 480 atgcagaaac ccacctgcac atgatgctcc gagaattgag ttacatcgtt gtctactcat 540 gaggatggca taatggagtg gtttgcagat ggccacatag cggtcgtagg ccattcctgt 600 gatgatgcag acctcgaccc ccccaaagaa gtgtgtggtg aacaactgtg tcatgcagtt 660 atgataggaa atgaccttct tccctgtcag taagtcagtc attagtttgg gtgtcacagt 720

Page 3258

069269_0225_SL.TXT ggaggtgtag aggaggtctg agagggcaag gtaattaagg aagaagtaca tgggctggtt aattagctga ctgtaggtga tagaagccat aataatcaga ttccccaacc agatagcgag gtaacagagt aagaaaaata aaaagcagag gatctggact ctcttactct tagaaagtcc caggagaata aattcagtaa cattattcct attttccat

780

840

900

939 <210> 2926 <211> 312 <212> PRT <213> Felis catus <400> 2926

Met Glu Asn Arg 1 Asn 5 Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Ser 10 15 Lys Ser Lys Arg Val Gln Ile Leu Cys Phe Leu Phe Phe Leu Leu Cys 20 25 30 Tyr Leu Ala Ile Trp Leu Gly Asn Leu Ile Ile Met Ala Ser Ile Thr 35 40 45 Tyr Ser Gln Leu Ile Asn Gln Pro Met Tyr Phe Phe Leu Asn Tyr Leu 50 55 60 Ala Leu Ser Asp Leu Leu Tyr Thr Ser Thr Val Thr Pro Lys Leu Met 65 70 75 80 Thr Asp Leu Leu Thr Gly Lys Lys Val Ile Ser Tyr His Asn Cys Met 85 90 95 Thr Gln Leu Phe Thr Thr His Phe Phe Gly Gly Val Glu Val Cys Ile 100 105 110 Ile Thr Gly Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 His Tyr Ala Ile Leu Met Ser Arg Gln Arg Cys Asn Ser Ile Leu Gly 130 135 140

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Ala Ser Cys Ala Gly Gly Phe Leu His Ser Ile Gly Leu Phe Leu Leu 145 150 155 160 Ala Ile Phe Leu Pro Phe Cys Gly Pro Asn Glu Ile Asp His Tyr Phe 165 170 175 Cys Asp Val Tyr Pro Leu Leu Lys Leu Ala Cys Thr Asp Thr His Lys 180 185 190 Ile Gly Phe Leu Val Ile Ala Asn Ser Gly Leu Met Gly Leu Gly Ile 195 200 205 Phe Val Val Leu Met Ala Ser Tyr Phe Met Ile Leu Cys Asn Val Arg 210 215 220 Ala Tyr Ser Ala Glu Asn Arg His Lys Ala Leu Ser Thr Cys Ser Ser 225 230 235 240 His Ile Thr Val Val Ile Leu Phe Phe Ala Pro Val Ile Phe Val Tyr 245 250 255 Ile Arg Pro Ala Thr Thr Leu Pro Glu Asp Lys Val Phe Thr Leu Phe 260 265 270 Tyr Thr Ile Ile Val Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg 275 280 285 Asn Thr Glu Met Lys Asn Ala Ile Arg Lys Val Trp Cys Gly Ala Arg 290 295 300 Phe Trp Lys Gly Lys Ser Met Ile 305 310 <210> 2927 <211> 932 <212> DNA <213> Felis catus <400> 2927 tcagcttctg tcctcacttc ccatgacatg gccccagagt ttctttacgg cgttcttcat 60

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ccccatgttt cttagtgcgt ctatgagagg gttgagcacg ggggcaatga cagtatagaa 120 aagagcaaac actttgtcct ctggtaaggt cgttgctggt cgaatgtaaa taaagactaa 180 aggagcaaaa aagagaacca ccacgatgat gtgggaactg catgtggaaa gggctttgtg 240 gcgattctcc gcggagtagg acctgacaat atataggatc atagcatagg ataccagcga 300 gaccacgaaa gtcaccagac ccatcagtcc taagttggca accaccaggg agaactattc 360 tgctcatgtc cgtgcaggcc atcttcagca aaggatacac atcgcagaag acgtgatcta 420 tttcactggg gtcacagtag ggtaagacga tggcgaggag aaactgacca aaaaggaatg 480 taggaaccca cccgcacacg aagccgcgag catggcattg cacttccact catgatgact 540 gcacagtgca ggggcctgca gatggccacg tgtcggtcat aggccatccc ggtgaggaca 600 aagacctcga tttccccaaa gaagtgcacg gtgaagagct gtgtcgtaca gccactgtag 660 gaaatgacct tcttttctgt cagcaagtca atgatgaact tgggggtcac agtggaggtg 720 tagaaaaggt ctgccaggga taggaaactc gggaagaaat acacagggtg gtcaataagt 780 tgactgcagg tgagagaaat cacgacaaga aggttgccaa tcaagatggc aatgtaacaa 840 aacaagaaca gtaaaaagca gaagacttct atttcttttt tctgagaaag tcctaaaaga 900 ataaattctg tgatgttatt cctattttcc at 932

<210> 2928 <211> 166 <212> PRT <213> Felis catus <400> 2928

Met Glu Asn Arg Asn Asn Ile Thr Glu Phe Ile Leu Leu Gly Leu Ser 1 5 10 15 Gln Lys Lys Glu Ile Glu Val Phe Cys Phe Leu Leu Phe Leu Phe Cys 20 25 30 Tyr Ile Ala Ile Leu Ile Gly Asn Leu Leu Val Val Ile Ser Leu Thr 35 40 45 Cys Ser Gln Leu Ile Asp His Pro Val Tyr Phe Phe Pro Ser Phe Leu 50 55 60

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Ser Leu Ala Asp Leu Phe Tyr Thr Ser Thr Val Thr Pro Lys Phe Ile 65 70 75 80 Ile Asp Leu Leu Thr Glu Lys Lys Val Ile Ser Tyr Ser Gly Cys Thr 85 90 95 Thr Gln Leu Phe Thr Val His Phe Phe Gly Glu Ile Glu Val Phe Val 100 105 110 Leu Thr Gly Met Ala Tyr Asp Arg His Val Ala Ile Cys Arg Pro Leu 115 120 125 His Cys Ala Val Ile Met Ser Gly Ser Ala Met Pro Cys Ser Arg Leu 130 135 140 Arg Val Arg Val Gly Ser Tyr Ile Pro Phe Trp Ser Val Ser Pro Arg 145 150 155 160 His Arg Leu Thr Leu Leu

165

<210> 2929 <211> 895 <212> DNA <213> Felis catus <400> 2929 cactttcatt ctcttgggct tttcagaata tccagaactc cagatgcctc tgttcctggt 60 attcctgacc atctacacag tcactgtttt gggaaatctg ggcatgatca tgattatcca 120 gatcaatccc aaactccaca cccccatgta tttttttctc agccatttat ctttggttga 180 tttctgttac tctacagtag tcacacccaa actattagaa aacttggttg tggaagacag 240 aaccatctcc ttcacaggct gcatcatgca attcttcttt gcgtgcatat tcgtggtgac 300 agaaaccttc atgttggccg tgatggcata tgaccgattt gtggcagttt gtaaccctct 360 tctgtacata gttgtcatgt ctcagaagct ttgttccttg ttggtgggtg catcatactc 420 ctggggtata gtgtgttccc tgactcttac ttacttccta ctgaaattat ccttcaaagg 480 aaataatatc ataaataact ttgtctgtga gcatgccgcc atcatctctg tgtcctgctc 540

Page 3262

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tgatccctac atgagccaga agattatttt aatctctgcc acattcaatg aaataagcag 600 cctggtgatc attctgctct cctatgtttc cgtttttatc actgtcatga agatgccttc 660 cactgggggg cgccacaagg ccttctccac gtgtgcttcc cacctgaccg ctatcacaat 720 cttccatggg accattctct tcctgtactg tgttcccaac tccaaaagtt catggctcat 780 ggtcaaggtg gcttctgtct tttacactgt ggtcattccc atgctgaacc cactgatcta 840 tagcctcagg aacaaagatg tgaaggagac agtcaagaag ttaatcaata ccaaa 895

<210> 2930 <211> 298 <212> PRT <213> Felis catus <400> 2930

Thr Phe Ile Leu Leu Gly Phe Ser Glu Tyr Pro Glu Leu Gln Met Pro 1 5 10 15 Leu Phe Leu Val Phe Leu Thr Ile Tyr Thr Val Thr Val Leu Gly Asn 20 25 30 Leu Gly Met Ile Met Ile Ile Gln Ile Asn Pro Lys Leu His Thr Pro 35 40 45 Met Tyr Phe Phe Leu Ser His Leu Ser Leu Val Asp Phe Cys Tyr Ser 50 55 60 Thr Val Val Thr Pro Lys Leu Leu Glu Asn Leu Val Val Glu Asp Arg 65 70 75 80 Thr Ile Ser Phe Thr Gly Cys Ile Met Gln Phe Phe Phe Ala Cys Ile 85 90 95 Phe Val Val Thr Glu Thr Phe Met Leu Ala Val Met Ala Tyr Asp Arg 100 105 110 Phe Val Ala Val Cys Asn Pro Leu Leu Tyr Ile Val Val Met Ser Gln 115 120 125

Page 3263

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Lys Leu Cys Ser Leu Leu Val Gly Ala Ser Tyr Ser Trp Gly Ile 140 Val 130 135 Cys Ser Leu Thr Leu Thr Tyr Phe Leu Leu Lys Leu Ser Phe Lys Gly 145 150 155 160 Asn Asn Ile Ile Asn Asn Phe Val Cys Glu His Ala Ala Ile Ile Ser 165 170 175 Val Ser Cys Ser Asp Pro Tyr Met Ser Gln Lys Ile Ile Leu Ile Ser 180 185 190 Ala Thr Phe Asn Glu Ile Ser Ser Leu Val Ile Ile Leu Leu Ser Tyr 195 200 205 Val Ser Val Phe Ile Thr Val Met Lys Met Pro Ser Thr Gly Gly Arg 210 215 220 His Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile 225 230 235 240 Phe His Gly Thr Ile Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Ser 245 250 255 Ser Trp Leu Met Val Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile 260 265 270 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 275 280 285 Glu Thr Val Lys Lys Leu Ile Asn Thr Lys 290 295

<210> 2931 <211> 885 <212> DNA <213> Felis catus <400> 2931 caccttcatt ctgttgggct tctcagaata tccagaactc cagatgccac ttttcctggt

Page 3264

069269_0225_SL.TXT

attcctgacc atctacatag tcactgttct tgggaatctg ggtatgatca tgatcatcag 120 gatcaatccc aaactccaca cccccatgta cttttttctc agccatttat ctttggttga 180 tttctgttac tctacagtag tcacacccaa actattagaa aacttggttg tggaagacag 240 aaccatctcc ttcacaggct gcatcatgca attcttcttt gcgtgcatat ttgtggtgac 300 agaaaccttc atgttggccg tgatggcata tgaccgattt gtggcagttt gtaaccctct 360 tctgtacaca gttgtcatgt ctcagaagct ttgttccttg ttggtgggag catcatattc 420 ttggagtata gcctgctcct taacatacac atactttttg ttgactttat ccttttgtgg 480 aactagcttc ataaacaact ttgtctgtga gcattctgcc attgtctctg tgtcctgctc 540 tgatccttac attagccaga gggtcatttt agtctctgcc acattcaacg aaataagcag 600 cctggtgatc attcttccct cctatgtttc catttttatc actgtcatga agatgccttc 660 cactgggggg cgccacaagg ccttctccac gtgtgcttct cacctgaccg ctgttacaat 720 tttccatggg accatactgt ttctgtattg tgttcccaac tccaaaagtt catggctcat 780 ggtcaaagta gcttctgtct tttacactgt ggtcattccc atgctgaacc cactgatcta 840 cagcctcagg aacaaagatg tgaaagaggc agtcaagacg ttaat 885

<210> 2932 <211> 295 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (295)..(295) <223> Any amino acid <400> 2932

Thr 1 Phe Ile Leu Leu Gly Phe Ser Glu Tyr Pro Glu Leu Gln Met Pro 5 10 15 Leu Phe Leu Val Phe Leu Thr Ile Tyr Ile Val Thr Val Leu Gly Asn 20 25 30 Leu Gly Met Ile Met Ile Ile Arg Ile Asn Pro Lys Leu His Thr Pro 35 40 45

Page 3265

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Met Tyr Phe Phe Leu Ser His Leu Ser Leu Val Asp Phe Cys Tyr Ser 60 50 55 Thr Val Val Thr Pro Lys Leu Leu Glu Asn Leu Val Val Glu Asp Arg 65 70 75 80 Thr Ile Ser Phe Thr Gly Cys Ile Met Gln Phe Phe Phe Ala Cys Ile 85 90 95 Phe Val Val Thr Glu Thr Phe Met Leu Ala Val Met Ala Tyr Asp Arg 100 105 110 Phe Val Ala Val Cys Asn Pro Leu Leu Tyr Thr Val Val Met Ser Gln 115 120 125 Lys Leu Cys Ser Leu Leu Val Gly Ala Ser Tyr Ser Trp Ser Ile Ala 130 135 140 Cys Ser Leu Thr Tyr Thr Tyr Phe Leu Leu Thr Leu Ser Phe Cys Gly 145 150 155 160 Thr Ser Phe Ile Asn Asn Phe Val Cys Glu His Ser Ala Ile Val Ser 165 170 175 Val Ser Cys Ser Asp Pro Tyr Ile Ser Gln Arg Val Ile Leu Val Ser 180 185 190 Ala Thr Phe Asn Glu Ile Ser Ser Leu Val Ile Ile Leu Pro Ser Tyr 195 200 205 Val Ser Ile Phe Ile Thr Val Met Lys Met Pro Ser Thr Gly Gly Arg 210 215 220 His Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Ala Val Thr Ile 225 230 235 240 Phe His Gly Thr Ile Leu Phe Leu Tyr Cys Val Pro Asn Ser Lys Ser 245 250 255

Page 3266

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Ser Trp Leu Met Val Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile 260 265 270 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 275 280 285 Glu Ala Val Lys Thr Leu Xaa 290 295

<210> 2933 <211> 949 <212> DNA <213> Felis catus <400> 2933

atggcactgg atgagggaaa tcagagctct gtgactatat ttatcctcct gggtttctcg 60 gagtacccat acctccaggc acccctcttc ctcatgttct tgaccatcta cacagtcact 120 ctggtgggaa acctgggcat cattgcggtt gtaaggatca accccaaact ccacacaccc 180 atgtactttt tcctcagtca tctatccttt ttggatattt gttattccag tgtatttaca 240 ccaaaactgc tagagatctt ggtcatggaa gacagaagta tctccttcaa agcatgcatg 300 gtgcaatttt tttttgtttg tgcatttgtg attacagaaa tgttcatgtt agcggttatg 360 gcctatgacc ggtttgtggc tgtttgcaac cccctgctct acacagtggc tatgtctcgg 420 aaactctgtg ccctcttggt agctggaacc tatgtatggg gtggaatatg ttccctgaca 480 ctcacatact ctcttttgga actatccttc tgtggtccca acattataca tcactttggc 540 tgtgagtatt ctgccatcct ttctttatcc tgctctgacc cctcctttag tcagaggatg 600 tgtttagtca tttccacatt caatgaggct tgtagcctcc tgattatcct cgcctcctat 660 atttttatag ttgtcaccat agtcaagatg ccatctactg gaggactcca gaaagccttc 720 tccacctgtg cctcccacct gaccaccatc accatcttcc atgggatcat ccttcttctc 780 tactgtgtgc ccaactccaa aagctcgtgg ctcctggtca aagtggccac tgtgtttttt 840 actgtcatga tccccatgtt gaaccctctt atttacagtc ttaggaacaa agatgtgaaa 900 gacacagcca gaaagttaat tcataccaaa ctgctttctc actcaatgt 949

Page 3267

069269_0225_SL.TXT <210> 2934 <211> 317 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (317)..(317) <223> Any amino acid

<400> 2934 Gly Asn Gln Ser Ser Val Thr Ile Phe Ile Leu Met Ala 1 Leu Asp Glu 5 10 15 Leu Gly Phe Ser Glu Tyr Pro Tyr Leu Gln Ala Pro Leu Phe Leu Met 20 25 30 Phe Leu Thr Ile Tyr Thr Val Thr Leu Val Gly Asn Leu Gly Ile Ile 35 40 45 Ala Val Val Arg Ile Asn Pro Lys Leu His Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ser His Leu Ser Phe Leu Asp Ile Cys Tyr Ser Ser Val Phe Thr 65 70 75 80 Pro Lys Leu Leu Glu Ile Leu Val Met Glu Asp Arg Ser Ile Ser Phe 85 90 95 Lys Ala Cys Met Val Gln Phe Phe Phe Val Cys Ala Phe Val Ile Thr 100 105 110 Glu Met Phe Met Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Val 115 120 125 Cys Asn Pro Leu Leu Tyr Thr Val Ala Met Ser Arg Lys Leu Cys Ala 130 135 140 Leu Leu Val Ala Gly Thr Tyr Val Trp Gly Gly Ile Cys Ser Leu Thr 145 150 155 160

Page 3268

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Leu Thr Tyr Ser Leu Leu Glu Leu Ser Phe 170 Cys Gly Pro Asn Ile 175 Ile 165 His His Phe Gly Cys Glu Tyr Ser Ala Ile Leu Ser Leu Ser Cys Ser 180 185 190 Asp Pro Ser Phe Ser Gln Arg Met Cys Leu Val Ile Ser Thr Phe Asn 195 200 205 Glu Ala Cys Ser Leu Leu Ile Ile Leu Ala Ser Tyr Ile Phe Ile Val 210 215 220 Val Thr Ile Val Lys Met Pro Ser Thr Gly Gly Leu Gln Lys Ala Phe 225 230 235 240 Ser Thr Cys Ala Ser His Leu Thr Thr Ile Thr Ile Phe His Gly Ile 245 250 255 Ile Leu Leu Leu Tyr Cys Val Pro Asn Ser Lys Ser Ser Trp Leu Leu 260 265 270 Val Lys Val Ala Thr Val Phe Phe Thr Val Met Ile Pro Met Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Thr Ala Arg 290 295 300 Lys Leu Ile His Thr Lys Leu Leu Ser His Ser Met Xaa 305 310 315 <210> 2935 <211> 863 <212> DNA <213> Felis catus <400> 2935 gttccactct tcctggcttt cttgtctatc tatatggtca ctgccgtggg caacgtgggc atgattataa tcatcaagat caatctgaaa ttccacacga tcatgcactt tttccttagt cacttgtcct ttgtagattt ctgttattcc accatagtga cgcctaaatt gttgaagaac

120

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ttgattgtgc aagacagaac cgtatctttc tccggttgca ttatgcagtt ctgctttgct 240 tgcatatttg gagtaacaga agcttttatg ttagcagcaa tggcctatga ccgttgtgtg 300 gcggtctgta atcccttgct ctatcttact attatgtctc caaagctctg tgctccgctg 360 gtggctgggt catactcatg gggtatagtg tgttccctga cacatatttt ctccttgcat 420 tatcctattg tgagtctaac atcataaata attttatctg tgaccactct gtaattgttt 480 ctgtcttctg ttcggacccc tatatcagcc agatgtgctg ttttattatt gccatattcg 540 atgaggtgag cagcttgatg gttattctga agtcctatac cctcattttt gtcactgtta 600 tgaggatgtc ttctgcaagt gggtgccgga aaaccctctc cacctgtgcc tcccacctga 660 cagccattac catcttccat gggaccatcc ttttcctcta ctgtatccct aatcctaaaa 720 cttcttggct cagagttaaa gtggcatctg tgttttacac agtagtgatt cccatgcgga 780 accccttaat ctacagcctt agaaacaaag atgtgaagga cacattgaga ttagttgttg 840 caaaattgct ttgtccctca ata 863 <210> 2936 <211> 162 <212> PRT <213> Felis catus <400> 2936 Met Gly Tyr Ser Val Phe Pro Asp Thr Tyr Phe Leu Leu Ala Leu Ser 1 5 10 15 Tyr Cys Glu Ser Asn Ile Ile Asn Asn Phe Ile Cys Asp His Ser Val 20 25 30 Ile Val Ser Val Phe Cys Ser Asp Pro Tyr Ile Ser Gln Met Cys Cys 35 40 45 Phe Ile Ile Ala Ile Phe Asp Glu Val Ser Ser Leu Met Val Ile Leu 50 55 60 Lys Ser Tyr Thr Leu Ile Phe Val Thr Val Met Arg Met Ser Ser Ala 65 70 75 80 Ser Gly Cys Arg Lys Thr Leu Ser Thr Cys Ala Ser His Leu Thr Ala

Page 3270

85 069269_0225_SL.TXT 90 95 Ile Thr Ile Phe His Gly Thr Ile Leu Phe Leu Tyr Cys Ile Pro Asn 100 105 110 Pro Lys Thr Ser Trp Leu Arg Val Lys Val Ala Ser Val Phe Tyr Thr 115 120 125 Val Val Ile Pro Met Arg Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys 130 135 140 Asp Val Lys Asp Thr Leu Arg Leu Val Val Ala Lys Leu Leu Cys Pro 145 150 155 160

Ser Ile <210> 2937 <211> 930 <212> DNA <213> Felis catus <400> 2937 gaaggaaacc acagtactgg agccacattc accctcttgg gcttctcaga atatccggat ctgcagattc ccttgttcct gctattcctg accgtctaca ccgtcactgt ggtggggaac ctgggcatga tcatgatcat cagggtcagt ccccaactcc acacccccat gtactttttc ctgagccact tgtcctttgt cgacttctgt tactccacta cagttacccc caaactgttg gagaacttgg ttgtggaaga cagaaccatc tctttcatag gctgcatagt gcaattcctg ttggcttgta tatttgcagt gtcagaaaca ttcatgttgg cagtgatggc ctatgaccgc tttgtggcag tttgtaaccc tctactctac aaagctgtca tgtcccaaaa gctgtgtgca tcgttagtgg cggggcccta cacatggggt gtagtctctt ccttgacact cacctatttt ctcctgacat tgtccttctg tggctctaac atcataaata attttgtctg cgagcactct gtcattgtct ctgtgtcctg ctctgacacc tacatcagcc aagtgctttg ttttgccatc gccatgttca atgaggtgag cagcctggta atcatcctca ctacttatat ttttattttt gtcactgtca taaaaatgcc ttctgctggt gggcgccaaa aagccttctc cacttgtgca Page 3271

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660

720

069269_0225_SL.TXT

tcccacctga ctgccatcac catcttccat gggaccgtct tgttccttta ctgtgtaccc 780 aactccaaaa actcatggct cataatcaaa gtaggttctt tattttatac cgtggtgatc 840 cccatgctga accctctaat ctatagcctc agaaacaaag atgtgaaaga gagtgtcagg 900 aaattaatta atcactcaat gcaattttgt 930

<210> 2938 <211> 310 <212> PRT <213> Felis catus <400> 2938

Glu Gly Asn His 1 Ser 5 Thr Gly Ala Thr Phe Thr Leu Leu Gly Phe Ser 10 15 Glu Tyr Pro Asp Leu Gln Ile Pro Leu Phe Leu Leu Phe Leu Thr Val 20 25 30 Tyr Thr Val Thr Val Val Gly Asn Leu Gly Met Ile Met Ile Ile Arg 35 40 45 Val Ser Pro Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser His Leu 50 55 60 Ser Phe Val Asp Phe Cys Tyr Ser Thr Thr Val Thr Pro Lys Leu Leu 65 70 75 80 Glu Asn Leu Val Val Glu Asp Arg Thr Ile Ser Phe Ile Gly Cys Ile 85 90 95 Val Gln Phe Leu Leu Ala Cys Ile Phe Ala Val Ser Glu Thr Phe Met 100 105 110 Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Val Cys Asn Pro Leu 115 120 125 Leu Tyr Lys Ala Val Met Ser Gln Lys Leu Cys Ala Ser Leu Val Ala 130 135 140

Page 3272

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Gly Pro Tyr Thr Trp Gly Val Val Ser Ser Leu Thr Leu Thr Tyr Phe 145 150 155 160 Leu Leu Thr Leu Ser Phe 165 Cys Gly Ser Asn 170 Ile Ile Asn Asn Phe Val 175 Cys Glu His Ser Val Ile 180 Val Ser Val Ser 185 Cys Ser Asp Thr 190 Tyr Ile Ser Gln Val Leu Cys Phe 195 Ala Ile 200 Ala Met Phe Asn Glu Val 205 Ser Ser Leu Val 210 Ile Ile Leu Thr Thr Tyr 215 Ile Phe Ile Phe Val Thr 220 Val Ile Lys Met 225 Pro Ser Ala Gly 230 Gly Arg Gln Lys Ala Phe Ser Thr 235 Cys Ala 240 Ser His Leu Thr Ala Ile 245 Thr Ile Phe His 250 Gly Thr Val Leu Phe Leu 255 Tyr Cys Val Pro Asn Ser 260 Lys Asn Ser Trp 265 Leu Ile Ile Lys 270 Val Gly Ser Leu Phe Tyr Thr Val 275 Val Ile 280 Pro Met Leu Asn Pro Leu 285 Ile Tyr Ser Leu Arg Asn Lys Asp 290 His Ser Met Gln Phe Cys 305 310 <210> 2939 <211> 907 <212> DNA <213> Felis catus <400> 2939 Val Lys 295 Glu Ser Val Arg Lys Leu 300 Ile Asn atgttacttt cagagagaaa taaaactggg gctgtgttca ctctcttggg cttctcagat 60

Page 3273 tacccagaac tgcaagtccc gtaggaaata ttgggatgat tactttttcc tcagccacct aagaccctgg caaacctagt caatattttt tcttttgtac tatgaccgct ttgtggccat ttctgtgcca tgctggtggt acatgttctg ctatcaggtt gagttctctg cattgctgtc ttcatttttg ccaccttcaa tttatcattg tcaccatcct acctgtgcct cccacctgac tgtgttccta actccaaaaa gtggtgatcc ctatgctgaa acagtca <210> 2940 <211> 303 <212> PRT <213> Felis catus

069269_0225_ tctcttcttg atttttttgg agttataatc aagattaact ctcatttgtg gatttctgct tgtagaagac aggaccattt ctttgtggta gctgaatcct ctgcaaacct ctgctctaca tggatcatac gcatggggag atctttccag ggtttcaaca cctgtcttgc tctgatattt cgtggtcagc acactgttta caagatgcgt tcagccagtg agccatcacc atcttctatg ctcgaggaac acagtgaaag tcccttgatc tacagtctga

L.TXT ccatctacag tgtcactgtt ccaaactgca cacccccatg attcctccat cattgttccc catttccagg atgtatagta ttttattggc tgtgatggcc cagtggccat gtcccagaaa tagcatgttc cctgatactc caatcaatca cttcttctgt acatcaatca gttgctgctt tcattctcat gtcttatgta gtcgtcgcaa agccttctcc ggaccattgt cttcctctac tggcgtctgt gttttacaca gaaataaaga catcaaggat

120

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360

420

480

540

600

660

720

780

840

900

907 <220>

<221> MOD_RES <222> (303)..(303) <223> Any amino acid <400> 2940

Met 1 Leu Leu Ser Glu 5 Arg Asn Lys Thr Gly Ala Val Phe Thr Leu Leu 10 15 Gly Phe Ser Asp Tyr Pro Glu Leu Gln Val Pro Leu Phe Leu Ile Phe 20 25 30 Leu Ala Ile Tyr Ser Val Thr Val Val Gly Asn Ile Gly Met Ile Val

Page 3274

069269_0225_SL.TXT 40 45

Ile Ile 50 Lys Ile Asn Ser Lys 55 Leu His Thr Pro Met Tyr Phe Phe 60 Leu Ser His Leu Ser Phe Val Asp Phe Cys Tyr Ser Ser Ile Ile Val Pro 65 70 75 80 Lys Thr Leu Ala Asn Leu Val Val Glu Asp Arg Thr Ile Ser Phe Pro 85 90 95 Gly Cys Ile Val Gln Tyr Phe Phe Phe Cys Thr Phe Val Val Ala Glu 100 105 110 Ser Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys 115 120 125 Lys Pro Leu Leu Tyr Thr Val Ala Met Ser Gln Lys Phe Cys Ala Met 130 135 140 Leu Val Val Gly Ser Tyr Ala Trp Gly Val Ala Cys Ser Leu Ile Leu 145 150 155 160 Thr Cys Ser Ala Ile Arg Leu Ser Phe Gln Gly Phe Asn Thr Ile Asn 165 170 175 His Phe Phe Cys Glu Phe Ser Ala Leu Leu Ser Leu Ser Cys Ser Asp 180 185 190 Ile Tyr Ile Asn Gln Leu Leu Leu Phe Ile Phe Ala Thr Phe Asn Val 195 200 205 Val Ser Thr Leu Phe Ile Ile Leu Met Ser Tyr Val Phe Ile Ile Val 210 215 220 Thr Ile Leu Lys Met Arg Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Ile Thr Ile Phe Tyr Gly Thr Ile

Page 3275

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245 250 255

Val Phe Leu Tyr Cys Val Pro Asn Ser Lys Asn Ser Arg Asn Thr Val 260 265 270 Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Asp Thr Val Xaa 290 295 300

<210> 2941 <211> 934 <212> DNA <213> Felis catus <400> 2941

gggcaaggga aactgctccg gtgtgaccga gttcattctc ctgggattcg cagaagcccc 60 tgagttgaga gttgccctct tctctgtgtt ctttctcatc tatggagtca cggtgctggg 120 caacctgggc atgatggcag tgattcaggt cagctgtcac cttcacactc ccatgtactt 180 tttcctcagc cacttgtcct ttgtggattt ttgctactcc accatcatcg tgccaaagat 240 gctaactaat atcttaaacg aggacaaaac catttccttc ctggggtgct gcgtgcaatt 300 ctacttgttt tgtacatgtg tggtaagtga ggtcttcctg ttggcggtca tggcctatga 360 ccgcttcgtg gccatctgga acccactgtt gtacacggtc accatgtccc ggaatctctg 420 tgtggagctg gtgtcttgtt gctacctgtg tgggatggtg tgttctctga tccacttgtg 480 tttagctctt gagatcacat cctacagatc aaatgtgatt gaccacttct tctgcgatct 540 gccccctctc ttatcccttg cttgctctga tgtgactatg aatgaactgc tgctgtacat 600 cgtggccacc ttcaatgaga tcaccaccat tgtgatcatc ctcacctcct acttgctaat 660 tctcatcacc atcctgagga tgcactctgc cgagggaagg cgcaaagcct tttccacctg 720 tgcctcccac ctcacagcca tccttgtctt ccacggaaca atccttttca cttactgccg 780 gcccagttct ggcaacagta tggatactga caaggtggcc acggtgttct acactgtagt 840 gattcccatg ctcaaccccc tcatctatag cctccggaac aaggatgtga aggaagcgct 900 cagaaaaatg gtgagctcca aaatattttc ctag 934

Page 3276

069269_0225_SL.TXT <210> 2942 <211> 310 <212> PRT <213> Felis catus

<400> 2942 Gly 1 Lys Gly Asn Cys 5 Ser Gly Val Thr Glu Phe Ile Leu Leu Gly Phe 10 15 Ala Glu Ala Pro Glu Leu Arg Val Ala Leu Phe Ser Val Phe Phe Leu 20 25 30 Ile Tyr Gly Val Thr Val Leu Gly Asn Leu Gly Met Met Ala Val Ile 35 40 45 Gln Val Ser Cys His Leu His Thr Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ser Phe Val Asp Phe Cys Tyr Ser Thr Ile Ile Val Pro Lys Met 65 70 75 80 Leu Thr Asn Ile Leu Asn Glu Asp Lys Thr Ile Ser Phe Leu Gly Cys 85 90 95 Cys Val Gln Phe Tyr Leu Phe Cys Thr Cys Val Val Ser Glu Val Phe 100 105 110 Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Trp Asn Pro 115 120 125 Leu Leu Tyr Thr Val Thr Met Ser Arg Asn Leu Cys Val Glu Leu Val 130 135 140 Ser Cys Cys Tyr Leu Cys Gly Met Val Cys Ser Leu Ile His Leu Cys 145 150 155 160 Leu Ala Leu Glu Ile Thr Ser Tyr Arg Ser Asn Val Ile Asp His Phe 165 170 175

Page 3277

069269_0225_SL.TXT

Phe Cys Asp Leu Pro Pro Leu Leu Ser Leu Ala Cys Ser Asp Val Thr 180 185 190 Met Asn Glu Leu Leu Leu Tyr Ile Val Ala Thr Phe Asn Glu Ile Thr 195 200 205 Thr Ile Val Ile Ile Leu Thr Ser Tyr Leu Leu Ile Leu Ile Thr Ile 210 215 220 Leu Arg Met His Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ser His Leu Thr Ala Ile Leu Val Phe His Gly Thr Ile Leu Phe 245 250 255 Thr Tyr Cys Arg Pro Ser Ser Gly Asn Ser Met Asp Thr Asp Lys Val 260 265 270 Ala Thr Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Arg Lys Met Val 290 295 300 Ser Ser Lys Ile Phe Ser

305 310 <210> 2943 <211> 945 <212> DNA <213> Felis catus <220>

<221> modified_base <222> (553)..(572) <223> a, c, t, g, unknown or other <400> 2943 aactgctcca gtgtgaccga gttcattctc ctcggattcg cagaagcccc cgagttgaga gtcgccctct tctctgtgtt ccttctcagc tatggagtca cggtgctggg caacctgggc

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atgatggcag tgattcaggt cagctgtcac cttcacactc ccatgtactt tttcctcagc 180 cacttgtcct ttgtggactt ttgctactcc accgtcatcg tgccaaatgt gctgtccagt 240 atcttaaaca agggcaaagc catctccttc ctgggatgca tggtgcaatt ctatttcttt 300 tgtgcctatg caatcactga ggtcttcctt ttggctgtga tggcctatga ccgcttcgtg 360 gccatctgca acccactgtt gtacatggtc accatgtccc agaatctctg tttggagctg 420 gtgtcttgtt gctacctgtg tgggatggtg tgttctctga tccacttgtg tttagctctt 480 gagatcacat cctacagatc aaatgtgatt gaccacttct tctgcgatct gccccctctc 540 ttgtcccttg ctnnnnnnnn nnnnnnnnnn nnactatgaa tgaactgctg ctgtacatcg 600 tggccacctt caatgagatc accaccatcg tgatcatcct cacctcctac ttgctaattc 660 tcatcaccat cctgaggatg cactctgccg agggaaggcg caaagccttt tccacctgtg 720 cctcccacct cacagccatc cttgtcttcc acggaacaat ccttttcact tactgccggc 780 ccagttctgg caacagtgtg gatactgaca aggtggccac ggtgttctac actgtagtga 840 ttcccatgct caaccccctc atctatagcc tccggaacaa ggatgtgaag gaagcactca 900 agaaagtgtt gggatctaga ttaccttttg aaaaactatt ttctt 945

<210> 2944 <211> 192 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (185)..(191) <223> Any amino acid <400> 2944

Asn Cys Ser Ser Val Thr Glu Phe Ile Leu Leu Gly Phe Ala Glu Ala 1 5 10 15 Pro Glu Leu Arg Val Ala Leu Phe Ser Val Phe Leu Leu Ser Tyr Gly 20 25 30 Val Thr Val Leu Gly Asn Leu Gly Met Met Ala Val Ile Gln Val Ser

35 40 45

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Cys His 50 Leu His Thr Pro Met Tyr Phe Phe Leu Ser His Leu Ser Phe 55 60 Val Asp Phe Cys Tyr Ser Thr Val Ile Val Pro Asn Val Leu Ser Ser 65 70 75 80 Ile Leu Asn Lys Gly Lys Ala Ile Ser Phe Leu Gly Cys Met Val Gln 85 90 95 Phe Tyr Phe Phe Cys Ala Tyr Ala Ile Thr Glu Val Phe Leu Leu Ala 100 105 110 Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Asn Pro Leu Leu Tyr 115 120 125 Met Val Thr Met Ser Gln Asn Leu Cys Leu Glu Leu Val Ser Cys Cys 130 135 140 Tyr Leu Cys Gly Met Val Cys Ser Leu Ile His Leu Cys Leu Ala Leu 145 150 155 160 Glu Ile Thr Ser Tyr Arg Ser Asn Val Ile Asp His Phe Phe Cys Asp 165 170 175 Leu Pro Pro Leu Leu Ser Leu Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu 180 185 190

<210> 2945 <211> 933 <212> DNA <213> Felis catus <400> 2945 atggaattgg agaacctcac tgtgaagact gagttctttc tcttgggatt tagtgagcat ccagaactct ggagggttct ttttgctgtg ttccttttta tctactctgt taccttaatg gggaacctag ggatgatgtc attaatcatg accagttcgc atttgcacac ccctatgtac tttttcctct gcatactgtc cttcgtcgat gtatgctact cctccgtcat tgcccccaaa ttacttgcag acttggtttc cgagaaaaag accatttctt acaagggctg tgctgcacag

120

180

240

300

Page 3280

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ttatattttt tctgttcttt ggttgacaca gaatctttcc tcttggctgc catggcttat 360 gaccggtacc tagccatctg caacccactg ctttatactg ttattatgtc caagaggctt 420 tgctgccagc ttgtgattgg agcattttgg gggggtacca tgagctcaat tattcacact 480 atcaatacct tccatctgtc tttctgctcc aaagaaatta accatttctt ctgtgatatc 540 tccccactct tctctctgtc ctgcactgat acttacatgc atgacattgt tctggtagtt 600 tttgctggtt tagtggaagc tatctgtctt ctaacagttc ttctctctta tgtctgcatc 660 atagcagcca ttcttaaaac aggttctgct gaaggaagaa gaaaagggtt ctccacttgt 720 gcttcccatc tgactgtggt cactatttac catggtaccc tcatttttat ttatttgcgc 780 cccagcgctg gtcattcgct ggatattgac aaagtgacct ctgtgttcta tacattgatt 840 atacctatgt tgaatccctt aatttacagt ctgaggaaca aagatgtcaa aaatgccttt 900 aggaaagtga tcagccgaaa attgctttct taa 933

<210> 2946 <211> 310 <212> PRT <213> Felis catus <400> 2946

Met Glu Leu Glu Asn Leu Thr Val Lys Thr Glu Phe Phe Leu Leu Gly 1 5 10 15 Phe Ser Glu His Pro Glu Leu Trp Arg Val Leu Phe Ala Val Phe Leu 20 25 30 Phe Ile Tyr Ser Val Thr Leu Met Gly Asn Leu Gly Met Met Ser Leu 35 40 45 Ile Met Thr Ser Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60 Ile Leu Ser Phe Val Asp Val Cys Tyr Ser Ser Val Ile Ala Pro Lys 65 70 75 80 Leu Leu Ala Asp Leu Val Ser Glu Lys Lys Thr Ile Ser Tyr Lys Gly

85 90 95

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Cys Ala Ala Gln 100 Leu Tyr Phe Phe Cys Ser Leu Val Asp Thr Glu Ser 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Thr Val Ile Met Ser Lys Arg Leu Cys Cys Gln Leu 130 135 140 Val Ile Gly Ala Phe Trp Gly Gly Thr Met Ser Ser Ile Ile His Thr 145 150 155 160 Ile Asn Thr Phe His Leu Ser Phe Cys Ser Lys Glu Ile Asn His Phe 165 170 175 Phe Cys Asp Ile Ser Pro Leu Phe Ser Leu Ser Cys Thr Asp Thr Tyr 180 185 190 Met His Asp Ile Val Leu Val Val Phe Ala Gly Leu Val Glu Ala Ile 195 200 205 Cys Leu Leu Thr Val Leu Leu Ser Tyr Val Cys Ile Ile Ala Ala Ile 210 215 220 Leu Lys Thr Gly Ser Ala Glu Gly Arg Arg Lys Gly Phe Ser Thr Cys 225 230 235 240 Ala Ser His Leu Thr Val Val Thr Ile Tyr His Gly Thr Leu Ile Phe 245 250 255 Ile Tyr Leu Arg Pro Ser Ala Gly His Ser Leu Asp Ile Asp Lys Val 260 265 270 Thr Ser Val Phe Tyr Thr Leu Ile Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Asn Ala Phe Arg Lys Val Ile 290 295 300

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Ser Arg Lys Leu Leu Ser 305 310 <210> 2947 <211> 921 <212> DNA <213> Felis catus <400> 2947

agtactgatt atttttttca gggcaccttt cacatcctta ttccgtaagc tgtagatcag 60 tgggtttaac attgggatga cgaccgtgta gaacacagag gccattttgt ccgtgtccat 120 agagtaactg gagctgggtc ggaaatacat gaacaggagt gtgccgtgaa atatggccac 180 tgcggtcaag tgggaggcac atgtagaaaa ggctttgcgt ctcccttcca ctgagttcat 240 tctgaggatg gtcattatga tgtaggtgta ggagaggagg acggtgatga cgctgcaccc 300 caccacacaa ccaatgaaag tgaacatcac tatctcgttt atagatgtat ccgaagacga 360 gagggacagc aagggtggga tgtcacagaa aaagtgattg atgatattgg aattgcagaa 420 tgccaatcga aacgtgcaac cggtgtggat tgccgaatcc acaaatccca cgatgtaggc 480 aagggccacg agctggatgc agattctcct ggacatggcc attgtataca gaagtggatt 540 acagatggct gcgtaccggt cgtaagccat gacagccaac atgagacact ccacatctgc 600 gaaggccccg aaaaaataca gctgaattgc acacgagttg tatggaatct tcttttgctc 660 agataagaag ccagccagca tcttgggaga cacagtggag gagtagcaga catcacagaa 720 agacaggttg ctcaggaaat aatacatggg tgtgtggagc ctggagtcca gtttgattag 780 caggatcatc cccagattgg caatcatggt tatggcataa accagcagaa agaacacaaa 840 gagcccctgc tgcacatctt ttcttccagt aagtcctagg agtatgaagt ccgtcatcac 900 agagcagttc tcaccagcca t 921

<210> 2948 <211> 307 <212> PRT <213> Felis catus <400> 2948

Met Ala Gly Glu Asn Cys Ser Val Met Thr Asp Phe Ile Leu Leu Gly Page 3283

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1 5 10 15 Leu Thr Gly Arg Lys Asp Val Gln Gln Gly Leu Phe Val Phe Phe Leu 20 25 30 Leu Val Tyr Ala Ile Thr Met Ile Ala Asn Leu Gly Met Ile Leu Leu 35 40 45 Ile Lys Leu Asp Ser Arg Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Asn Leu Ser Phe Cys Asp Val Cys Tyr Ser Ser Thr Val Ser Pro Lys 65 70 75 80 Met Leu Ala Gly Phe Leu Ser Glu Gln Lys Lys Ile Pro Tyr Asn Ser 85 90 95 Cys Ala Ile Gln Leu Tyr Phe Phe Gly Ala Phe Ala Asp Val Glu Cys 100 105 110 Leu Met Leu Ala Val Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Thr Met Ala Met Ser Arg Arg Ile Cys Ile Gln Leu 130 135 140 Val Ala Leu Ala Tyr Ile Val Gly Phe Val Asp Ser Ala Ile His Thr 145 150 155 160 Gly Cys Thr Phe Arg Leu Ala Phe Cys Asn Ser Asn Ile Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Pro Pro Leu Leu Ser Leu Ser Ser Ser Asp Thr 180 185 190 Ser Ile Asn Glu Ile Val Met Phe Thr Phe Ile Gly Cys Val Val Gly 195 200 205 Cys Ser Val Ile Thr Val Leu Leu Ser Tyr Thr Tyr Ile Ile Met Thr

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210 215 220

Ile 225 Leu Arg Met Asn Ser Val Glu Gly Arg Arg Lys Ala Phe Ser Thr 230 235 240 Cys Ala Ser His Leu Thr Ala Val Ala Ile Phe His Gly Thr Leu Leu 245 250 255 Phe Met Tyr Phe Arg Pro Ser Ser Ser Tyr Ser Met Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Lys Lys Ile

290 295 300

Ile Ser Thr 305 <210> 2949 <211> 912 <212> DNA <213> Felis catus <400> 2949

aagttttttc cgagcctctt tcacatcttt gttccgcagg ctataaatca cagggtttaa 60 catgggaatc acaagggtgt agaacaagga ggtcattttg tcttgatcaa gagagtagga 120 agaactcggg cggaaataca taaagagcag ggttccctgg aaaattgcaa cagcagttaa 180 gtgggaggtg caggtggaga aagctttgaa cctcccctca gcagagcgga tctttatcac 240 tgccaggatg atataacagt aagacacaaa gagccctgaa agggtaatca gctcaatgaa 300 gccaaaaatg gtgaatatca ctaactcatt aacttgggta tctgagcaag ataacaaaag 360 gagaggtggg acatcacaga agaagtggtt gatcacattt gatccacaga aacataacct 420 gaatgataat attgtatttg cagaagcatc cacaagccct accatgtaaa ccccagccat 480 gagcagaaag cacactctgc tggacatgtt ggccgtgtag agcaaggggt tgctaatggc 540 cttgtaccga tcaaaggcca tcaccgccag cagtaggcac tcagaatcag caaaggtaca 600

Page 3285

069269_0225_SL.TXT gaagatccag aattgcagag cacagccata gaaaggaatt gactttatct tggtaatgag gcccaccagc atccggggcc caattgctgt agaataacag aggtcactga aagagaggtg gctgaggaag aaatacattg gtgtgtgaag cttagaatcc attctaatta acatgatcat cccgaggttt gcaataagaa tgatgagata aacaattaga aatgtgacaa acagggtcac tttaattcca gggttattgc taattcccag gagaaggaat tcattcacag aagagcaatt ttttccatcc at

660

720

780

840

900

912 <210> 2950 <211> 304 <212> PRT <213> Felis catus <400> 2950

Met Asp Gly Lys Asn Cys Ser Ser Val Asn Glu Phe Leu Leu Leu Gly 1 5 10 15 Ile Ser Asn Asn Pro Gly Ile Lys Val Thr Leu Phe Val Thr Phe Leu 20 25 30 Ile Val Tyr Leu Ile Ile Leu Ile Ala Asn Leu Gly Met Ile Met Leu 35 40 45 Ile Arg Met Asp Ser Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Ser Asp Leu Cys Tyr Ser Thr Ala Ile Gly Pro Arg 65 70 75 80 Met Leu Val Gly Leu Ile Thr Lys Ile Lys Ser Ile Pro Phe Tyr Gly 85 90 95 Cys Ala Leu Gln Phe Trp Ile Phe Cys Thr Phe Ala Asp Ser Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ala Phe Asp Arg Tyr Lys Ala Ile Ser Asn 115 120 125

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Pro Leu 130 Leu Tyr Thr Ala Asn Met 135 Ser Ser Arg Val Cys Phe Leu 140 Leu Met Ala 145 Gly Val Tyr Met Val Gly 150 Leu Val Asp Ala Ser Ala Asn 155 Thr 160 Ile Leu Ser Phe Arg Leu Cys Phe 165 Cys Gly Ser Asn Val Ile Asn 170 175 His Phe Phe Cys Asp Val Pro Pro Leu 180 Leu Leu Leu Ser Cys Ser Asp 185 190 Thr Gln Val Asn Glu Leu Val Ile Phe 195 200 Thr Ile Phe Gly Phe Ile Glu 205 Leu Ile Thr 210 Leu Ser Gly Leu Phe Val 215 Ser Tyr Cys Tyr Ile Ile Leu 220 Ala Val Ile 225 Lys Ile Arg Ser Ala Glu 230 Gly Arg Phe Lys Ala Phe Ser 235 Thr 240 Cys Thr Ser His Leu Thr Ala Val 245 Ala Ile Phe Gln Gly Thr Leu 250 255 Leu Phe Met Tyr Phe Arg Pro Ser Ser 260 Ser Tyr Ser Leu Asp Gln Asp 265 270 Lys Met Thr Ser Leu Phe Tyr Thr Leu 275 280 Val Ile Pro Met Leu Asn Pro 285 Val Ile Tyr Ser Leu Arg Asn Lys Asp 290 295 <210> 2951 <211> 928 <212> DNA <213> Felis catus <400> 2951 Val Lys Glu Ala Arg Lys Lys 300 Leu tattttgttt ttcaattttt ctaaggccct ttttacgtcc ttgttccgta ggctataaat

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cagtgggttt aacatgggaa tcacaagggt gtaaaacaag gaggtcattt tgtcttgatc 120 aagagagtag gaagaactcg gccggaaata catgaagatc atggtcccct ggaaaattgc 180 aacagtagtt atgtgggagg tgcaggtgga gaaagctttg aacctcccct cagcagagtg 240 gatcttcagg acggatagga ttatataaca ataagagaca aggactactg aaatggtgct 300 cagttcaatg aagccaaaaa tggtgaatat tgctaattcg ttgagttgtg tgtctgcgca 360 agagagcaat aggagagggg gtacatcaca gaagaagtga ttaatcaatc tcctttgatc 420 cacagaaaca taaccggaat gttagtgtcg tgtgtatcaa agcatctgcc gttgccagca 480 cgtaaacccc cgccatgagc aggaagcaca ctctgctgga catgttgacc gtgtagagca 540 aggggttgct aatggcctcg taccgatcaa aggccatcac tgccagcagt aggcactcag 600 aatcagcaaa cgtacagaag accaagaatt gcagagcaca gccaacgaaa gggattgatg 660 tgtttttggc tagaagttct accaaagttt tgggcccaat tgctgtggaa taacagaggt 720 cacagaaaga gaggtggcta aggaaaaagt acattggtgt gttcagctga gaactcattc 780 taattagaat aatcattccg aggtttgcca ggagattagt gagataaata agcaggatgg 840 tggtgaatag agtcactttg atctcagagt tgtccgtaat tcccaagaga aagaattcag 900 tcaaggagga gcagttttct ttgtccat 928

<210> 2952 <211> 175 <212> PRT <213> Felis catus <400> 2952

Met Asp Lys Glu Asn Cys Ser Ser Leu Thr Glu Phe Phe Leu Leu Gly 1 5 10 15 Ile Thr Asp Asn Ser Glu Ile Lys Val Thr Leu Phe Thr Thr Ile Leu 20 25 30 Leu Ile Tyr Leu Thr Asn Leu Leu Ala Asn Leu Gly Met Ile Ile Leu 35 40 45 Ile Arg Met Ser Ser Gln Leu Asn Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60

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His 65 Leu Ser Phe Cys Asp 70 Leu Cys Tyr Ser Thr Ala Ile Gly Pro Lys 75 80 Thr Leu Val Glu Leu Leu Ala Lys Asn Thr Ser Ile Pro Phe Val Gly 85 90 95 Cys Ala Leu Gln Phe Leu Val Phe Cys Thr Phe Ala Asp Ser Glu Cys 100 105 110 Leu Leu Leu Ala Val Met Ala Phe Asp Arg Tyr Glu Ala Ile Ser Asn 115 120 125 Pro Leu Leu Tyr Thr Val Asn Met Ser Ser Arg Val Cys Phe Leu Leu 130 135 140 Met Ala Gly Val Tyr Val Leu Ala Thr Ala Asp Ala Leu Ile His Thr 145 150 155 160 Thr Leu Thr Phe Arg Leu Cys Phe Cys Gly Ser Lys Glu Ile Asp 165 170 175

<210> 2953 <211> 934 <212> DNA <213> Felis catus <400> 2953 tcaatgaaac caccgtctat ttttaatttt tttcagagct ttgttcacat ctttgttccg 60 gaggctgtaa atcataggat ttaacatggg aatcacaagg gtataaaaca aggaggtcat 120 tttgtcttga tcagagtagg aagagtagga agaacttggc cggaaataca taaagagcag 180 ggtcccctgg aaagttgcaa cagcagttaa gtgggaggca caggtggaga aagctttgaa 240 cctcccctca gcagagcgga tctttatcac tgccaggatg atctaacagt aagatgcaaa 300 gagccctgaa agggtaatca gctcagtgaa gccaaaaatg gtgaatatca ctaactcatt 360 aacttgtgta tctgagcaag ataacaaaag gagaggtggg acatcacaga agaagtcgtt 420 gatcacattt gactcacaga aacataagtg aaatattaat attgtattta cagaagcatc 480 cacaattccc atcatgtaaa ccccagccgt gagcagaaag cacactctgc tggacgtgtt 540

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ggtcgtgtag agcaaggggt tgctaatgac cttgtagcga tcaaaggcca tcactgccaa 600 ccatagacac tcagaatcta caaaggtgca gaagatccag aattgcagag aacagccata 660 gaaggaaatt gacttgttct ttgcagtgag gcctaccagc atctggggtc caattgctgt 720 agaataacag aaggagaggt agctgaggaa gaaatacact ggtgtgtgaa gctgggaatc 780 cattctgatt aaaatgatca tcccaaggat tgcaaccaga atgatgagat aagcaactag 840 aaatgtgata aatagggtca ctttaattcc agggttattg ctaattccca ggagaaggaa 900 ttcattcaaa gaagagcaat ttttttccat ccat 934

<210> 2954 <211> 216 <212> PRT <213> Felis catus

<400> 2954 Cys Ser Ser Leu Asn Glu Phe Leu Leu Leu Gly Trp 1 Met Glu Lys Asn 5 10 15 Ile Ser Asn Asn Pro Gly Ile Lys Val Thr Leu Phe Ile Thr Phe Leu 20 25 30 Val Ala Tyr Leu Ile Ile Leu Val Ala Ile Leu Gly Met Ile Ile Leu 35 40 45 Ile Arg Met Asp Ser Gln Leu His Thr Pro Val Tyr Phe Phe Leu Ser 50 55 60 Tyr Leu Ser Phe Cys Tyr Ser Thr Ala Ile Gly Pro Gln Met Leu Val 65 70 75 80 Gly Leu Thr Ala Lys Asn Lys Ser Ile Ser Phe Tyr Gly Cys Ser Leu 85 90 95 Gln Phe Trp Ile Phe Cys Thr Phe Val Asp Ser Glu Cys Leu Trp Leu 100 105 110 Ala Val Met Ala Phe Asp Arg Tyr Lys Val Ile Ser Asn Pro Leu Leu 115 120 125

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Tyr Thr 130 Thr Asn Thr Ser Ser Arg Val Cys Phe Leu Leu Thr Ala Gly 135 140 Val Tyr Met Met Gly Ile Val Asp Ala Ser Val Asn Thr Ile Leu Ile 145 150 155 160 Phe His Leu Cys Phe Cys Glu Ser Asn Val Ile Asn Asp Phe Phe Cys 165 170 175 Asp Val Pro Pro Leu Leu Leu Leu Ser Cys Ser Asp Thr Gln Val Asn 180 185 190 Glu Leu Val Ile Phe Thr Ile Phe Gly Phe Thr Glu Leu Ile Thr Leu 195 200 205 Ser Gly Leu Phe Ala Ser Tyr Cys 210 215

<210> 2955 <211> 862 <212> DNA <213> Felis catus <400> 2955 tgggtttaac atgggaatca caagggtgta gaacaaggag gtcattttgt cttgatcaag 60 agagtaggaa gaactcggcc ggaaatacat gaagagcagg ggtcccctgg aaagttgcaa 120 cagcagttaa gtgggaggtg caggtggaga aagctttgaa cctcccctca gcagagtgaa 180 ccttcaggac ggataggatt atataacaat aagagataag gactcctaaa atggtactca 240 gttcaatgaa gccaaaaaat gtgaataatg ccaactcatt gatctctgta tttgagcagg 300 aaagaaggta gagtggaggt agatcacaga agaaatgatt aatctccttt gatccacaga 360 aacataaccg gaatgttagt gtcgtgtgta tcaaagcatc tgccgttgcc agcacgtaaa 420 ccccggccat gagcaggaag cacactctgc tggacatgtt aaccgtgtag agcaaggggt 480 tgctaatggc cttgtaccga tcaaaggcca tcactgccag cagtaggcac tcagaatcag 540 caaatgtaca gaagaccaag aattgcagag cacagccaac gaaagggatt gatgtgtttt 600

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069269_0225_SL.TXT tggctagaag gtctaccaac attttgggcc caatagctgt ggaataacag aggtcacaga aagagaggtg gctaaggaaa aagtacattg gtgtgttcag ctgagaattc attctaatta gaataatcat tccgaggttt gcaaaaagat taatgagata aataataaga aacattgtaa atagggttgt tttcatccca gggttattgg taattcccaa gaaaatgaaa tcagtcaagg atgaacaatt tcctccatcc at

660

720

780

840

862 <210> 2956 <211> 268 <212> PRT <213> Felis catus <400> 2956

Met Asp Gly Gly Asn Cys Ser Ser Leu Thr Asp Phe Ile Phe Leu Gly 1 5 10 15

Ile Thr Asn Asn Pro Gly Met Lys Thr Thr Leu Phe Thr Met Phe Leu 20 25 30

Ile Ile Tyr Leu Ile Asn Leu Phe Ala Asn Leu Gly Met Ile Ile Leu 35 40 45

Ile Arg Met Asn Ser Gln Leu Asn Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60

His Leu Ser Phe Cys Asp Leu Cys Tyr Ser Thr Ala Ile Gly Pro Lys 65 70 75 80

Met Leu Val Asp Leu Leu Ala Lys Asn Thr Ser Ile Pro Phe Val Gly 85 90 95

Cys Ala Leu Gln Phe Leu Val Phe Cys Thr Phe Ala Asp Ser Glu Cys 100 105 110

Leu Leu Leu Ala Val Met Ala Phe Asp Arg Tyr Lys Ala Ile Ser Asn 115 120 125

Pro Leu Leu Tyr Thr Val Asn Met Ser Ser Arg Val Cys Phe Leu Leu 130 135 140

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Met Ala Gly Val Tyr Val Leu Ala Thr Ala Asp Ala Leu Ile His Thr 145 150 155 160 Thr Leu Thr Phe Arg Leu Cys Phe Cys Gly Ser Lys Glu Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Pro Pro Leu Tyr Leu Leu Ser Cys Ser Asn Thr 180 185 190 Glu Ile Asn Glu Leu Ala Leu Phe Thr Phe Phe Gly Phe Ile Glu Leu 195 200 205 Ser Thr Ile Leu Gly Val Leu Ile Ser Tyr Cys Tyr Ile Ile Leu Ser 210 215 220 Val Leu Lys Val His Ser Ala Glu Gly Arg Phe Lys Ala Phe Ser Thr 225 230 235 240 Cys Thr Ser His Leu Thr Ala Val Ala Thr Phe Gln Gly Thr Pro Ala 245 250 255 Leu His Val Phe Pro Ala Glu Phe Phe Leu Leu Ser 260 265

<210> 2957 <211> 945 <212> DNA <213> Felis catus <400> 2957

tcacgaggca tctaccttta atcgtacagc tctcttagcg gcatctttga catctttatt 60 tctcaaacta taaatcaatg gattcagcac tgggatgatg atggtgtaga acacggagat 120 aattttatca gtgttaggag aatatagata gctgggcctt gagtaaatga agaggagagt 180 cccctgatag atggccactg aagtcaggtg agaggcacat gtggaaaagg ttttcttcct 240 cccactggaa gaacggatct ttaagactga gcgaaggatg aaaaagtagg agatgatgat 300 gacaatgaaa cagataattt ccactgagct gccatatgtg gagagaagcc actcattaac 360 tgatgtgtct gtgcaggata acttaagcag tggggggagg tcacagaaaa aatgattaat 420

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gacattttta tcacagtatt tcagaataaa ggcaaaggac gtatgaacca gggaactcag 480 gttgcctcca atgtaggaca atacaatcaa ccatatacag atgtcccgag acatcacaac 540 catatacagt aaagggttac agatggcgac gtagcgatcg tatgccatgg cagccaagat 600 aaaggattct gtatcagcaa aagcacagaa aaaataaaac tggagggcac agccataata 660 agagatagat ttgttctctg agaggaaatt gatgagcatt ttgggaacaa tgactgagga 720 gtaacagagg tctgcaaagg ataagttgct aaggaaaaaa tacatggggg tttgaaggtg 780 agaatcagtc ctgattaata tcatcagtcc aatgttccct gttaaaatca taccatacag 840 tgtcagaaac atgaggaata ggacaatctg cagttcaggg cgggtcggaa accctaaaag 900 aataaactca gtcaccaaag tgtagtttcc atctatcaat tccat 945

<210> 2958 <211> 314 <212> PRT <213> Felis catus

<400> 2958 Gly Asn Tyr Thr Leu Val Thr Glu Phe Ile Leu Met Glu 1 Leu Ile Asp 5 10 15 Leu Gly Phe Pro Thr Arg Pro Glu Leu Gln Ile Val Leu Phe Leu Met 20 25 30 Phe Leu Thr Leu Tyr Gly Met Ile Leu Thr Gly Asn Ile Gly Leu Met 35 40 45 Ile Leu Ile Arg Thr Asp Ser His Leu Gln Thr Pro Met Tyr Phe Phe 50 55 60 Leu Ser Asn Leu Ser Phe Ala Asp Leu Cys Tyr Ser Ser Val Ile Val 65 70 75 80 Pro Lys Met Leu Ile Asn Phe Leu Ser Glu Asn Lys Ser Ile Ser Tyr 85 90 95 Tyr Gly Cys Ala Leu Gln Phe Tyr Phe Phe Cys Ala Phe Ala Asp Thr 100 105 110

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Glu Ser Phe 115 Ile Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 120 125 Cys Asn Pro Leu Leu Tyr Met Val Val Met Ser Arg Asp Ile Cys Ile 130 135 140 Trp Leu Ile Val Leu Ser Tyr Ile Gly Gly Asn Leu Ser Ser Leu Val 145 150 155 160 His Thr Ser Phe Ala Phe Ile Leu Lys Tyr Cys Asp Lys Asn Val Ile 165 170 175 Asn His Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ser Cys Thr 180 185 190 Asp Thr Ser Val Asn Glu Trp Leu Leu Ser Thr Tyr Gly Ser Ser Val 195 200 205 Glu Ile Ile Cys Phe Ile Val Ile Ile Ile Ser Tyr Phe Phe Ile Leu 210 215 220 Arg Ser Val Leu Lys Ile Arg Ser Ser Ser Gly Arg Lys Lys Thr Phe 225 230 235 240 Ser Thr Cys Ala Ser His Leu Thr Ser Val Ala Ile Tyr Gln Gly Thr 245 250 255 Leu Leu Phe Ile Tyr Ser Arg Pro Ser Tyr Leu Tyr Ser Pro Asn Thr 260 265 270 Asp Lys Ile Ile Ser Val Phe Tyr Thr Ile Ile Ile Pro Val Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Ala Lys 290 295 300 Arg Ala Val Arg Leu Lys Val Asp Ala Ser 305 310

Page 3295

069269_0225_SL.TXT <210> 2959 <211> 935 <212> DNA <213> Felis catus <400> 2959 tcacgccatt tttttaagta atagttttct cagggctgca gtcacatcct tgttcctaag 60 actgtatatc aggggattaa acattggcgt cactgtggta tagaaaagag agagcagtct 120 gtcagttcct gcagaatgat tggacttggg ccttatgtag gtaatggtag cggatccaaa 180 gaataaaaac acgaccagca ggtgggaaga acaggtggaa aaagctttgg cccgtcctcc 240 ggcggttggc aacttgagaa tggtggaaat gattttgctg taagagacaa gtatcaacac 300 aaaaggaagt gtgacaaaca acatagctac tacatagacc gatatctcat gtacaaagag 360 gtccccacag gctagccgga ggatgggggg tatgtcgcag aagaagtggt tgatttggtt 420 agaattacag aaatgcagag agaaaatctg acatgtttgt cctatctgga ctgggactcc 480 accgatccag gagccaatgg ccagttggat acacatcttc tggttcatga ctagagagta 540 gtgcagaggg ttacaaatgg ccacgtagcg gtcataggcc attactgtca ggaggaaaca 600 ctcagtggct cccaacgcga ggaagaagca catctgggag gcacagccca gcatagaaat 660 gcttctatcc tgagtccaaa ggttcaccag aatcctaggg agagtgacgg acacgtaaca 720 gatttccagc gaggaaagat gcgccaggaa aaaatacatg ggtttctgta gtgccttgtc 780 aagcctggtt attgttatta cgaggctatt tccaattaag ataataacgt aaatggtgga 840 gaacactcca aatagtaacc gctggaggtt tggaaggtca gaaaatccca agagaacaaa 900 ttgctttatg gtggaagtat tatcatctgc tttca 935 <210> 2960 <211> 310 <212> PRT <213> Felis catus <400> 2960

Lys Ala Asp Asp Asn Thr Ser Thr Ile Lys Gln Phe Val Leu Leu Gly

1 5 10 15

Phe Ser Asp Leu Pro Asn Leu Gln Arg Leu Leu Phe Gly Val Phe Ser

Page 3296

069269_0225_SL.TXT 25 30

Thr Ile Tyr 35 Val Ile Ile Leu Ile Gly Asn Ser Leu Val Ile Thr Ile 40 45 Thr Arg Leu Asp Lys Ala Leu Gln Lys Pro Met Tyr Phe Phe Leu Ala 50 55 60 His Leu Ser Ser Leu Glu Ile Cys Tyr Val Ser Val Thr Leu Pro Arg 65 70 75 80 Ile Leu Val Asn Leu Trp Thr Gln Asp Arg Ser Ile Ser Met Leu Gly 85 90 95 Cys Ala Ser Gln Met Cys Phe Phe Leu Ala Leu Gly Ala Thr Glu Cys 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu His Tyr Ser Leu Val Met Asn Gln Lys Met Cys Ile Gln Leu 130 135 140 Ala Ile Gly Ser Trp Ile Gly Gly Val Pro Val Gln Ile Gly Gln Thr 145 150 155 160 Cys Gln Ile Phe Ser Leu His Phe Cys Asn Ser Asn Gln Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Pro Pro Ile Leu Arg Leu Ala Cys Gly Asp Leu 180 185 190 Phe Val His Glu Ile Ser Val Tyr Val Val Ala Met Leu Phe Val Thr 195 200 205 Leu Pro Phe Val Leu Ile Leu Val Ser Tyr Ser Lys Ile Ile Ser Thr 210 215 220 Ile Leu Lys Leu Pro Thr Ala Gly Gly Arg Ala Lys Ala Phe Ser Thr

Page 3297

069269_0225_SL.TXT

225 230 235 240 Cys Ser Ser His Leu Leu Val Val Phe Leu Phe Phe Gly Ser Ala Thr 245 250 255 Ile Thr Tyr Ile Arg Pro Lys Ser Asn His Ser Ala Gly Thr Asp Arg 260 265 270 Leu Leu Ser Leu Phe Tyr Thr Thr Val Thr Pro Met Phe Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Thr Ala Ala Leu Arg Lys Leu 290 295 300 Leu Leu Lys Lys Met Ala

305 310 <210> 2961 <211> 942 <212> DNA <213> Felis catus <400> 2961

ttacttatat agcaatcttc tcaatgccat gatgacatcc ttgttcctta gactgtatat 60 cataggatta aacatgggag tcacaattgt gtagaaaaga gaaagtactt tgtcaattcc 120 tgctgagtga ctgtgtttgg gtcttaagta agtgataacg gctgatccaa agaacaacgc 180 cacgacaata agatgagaaa aacaggtgga gaaggctttg gcccgacttg tggctgatgg 240 caattgaagg actgtggaga tgattttgct ataggagata agtatcaaca gaaagggaat 300 ggtgacaatc aacacagcag ctatgtagat caacatttca ctcacaaatg tgtccccaca 360 agcaagcttg aggattgggg ggatgtcaca gaagaagtgg tcaattaaat tggagccaca 420 aaaggacaga gagaaaatct ggaacgtttg ccctatctgg actggaattc cactgatcca 480 ggagccagcc accagctgga tacagatctt atgattcatg actagagggt agtgcagagg 540 gttacagatg gccacgtagc ggtcataggc catcactgtc agcaggaaac actccgtggc 600 tcccaacaca agaatacagc acatctgtgt ggcacaggca actaatgaaa ttgttcttct 660 ctgggtccaa aggttcataa gcattctggg gagagtaact gacacatagc agatttctaa 720

Page 3298

069269_0225_SL.TXT aaaggaaaaa ttgccaagga aatagtacat aggagtctga agtgcaggat ccaattttgt tattagaaat atgatgccat tactcatcac aatagtgata tagatgaccg agaacaatcc aaatagaagc caccggagat ggggaacatc agcaaagtcc aagagaacaa attctatcag ttcagttagg tttgcttctg gtggtttttc tttgtgttgc at

780

840

900

942 <210> 2962 <211> 313 <212> PRT <213> Felis catus <400> 2962

Met 1 Gln His Lys Glu Lys 5 Pro Pro Glu Ala Asn Leu Thr Glu Leu Ile 10 15 Glu Phe Val Leu Leu Asp Phe Ala Asp Val Pro His Leu Arg Trp Leu 20 25 30 Leu Phe Gly Leu Phe Ser Val Ile Tyr Ile Thr Ile Val Met Ser Asn 35 40 45 Gly Ile Ile Phe Leu Ile Thr Lys Leu Asp Pro Ala Leu Gln Thr Pro 50 55 60 Met Tyr Tyr Phe Leu Gly Asn Phe Ser Phe Leu Glu Ile Cys Tyr Val 65 70 75 80 Ser Val Thr Leu Pro Arg Met Leu Met Asn Leu Trp Thr Gln Arg Arg 85 90 95 Thr Ile Ser Leu Val Ala Cys Ala Thr Gln Met Cys Cys Ile Leu Val 100 105 110 Leu Gly Ala Thr Glu Cys Phe Leu Leu Thr Val Met Ala Tyr Asp Arg 115 120 125 Tyr Val Ala Ile Cys Asn Pro Leu His Tyr Pro Leu Val Met Asn His 130 135 140

Page 3299

069269_0225_SL.TXT

Lys Ile Cys Ile Gln Leu Val Ala Gly Ser Trp Ile Ser Gly Ile Pro 145 150 155 160 Val Gln Ile Gly Gln Thr Phe Gln Ile Phe Ser Leu Ser Phe Cys Gly 165 170 175 Ser Asn Leu Ile Asp His Phe Phe Cys Asp Ile Pro Pro Ile Leu Lys 180 185 190 Leu Ala Cys Gly Asp Thr Phe Val Ser Glu Met Leu Ile Tyr Ile Ala 195 200 205 Ala Val Leu Ile Val Thr Ile Pro Phe Leu Leu Ile Leu Ile Ser Tyr 210 215 220 Ser Lys Ile Ile Ser Thr Val Leu Gln Leu Pro Ser Ala Thr Ser Arg 225 230 235 240 Ala Lys Ala Phe Ser Thr Cys Phe Ser His Leu Ile Val Val Ala Leu 245 250 255 Phe Phe Gly Ser Ala Val Ile Thr Tyr Leu Arg Pro Lys His Ser His 260 265 270 Ser Ala Gly Ile Asp Lys Val Leu Ser Leu Phe Tyr Thr Ile Val Thr 275 280 285 Pro Met Phe Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys Asp Val Ile 290 295 300 Met Ala Leu Arg Arg Leu Leu Tyr Lys 305 310 <210> 2963 <211> 939 <212> DNA <213> Felis catus <400> 2963 cttcgttagt agttttctta gtgctaccgt gatgtctttg ttcctcagag tatatataat 60

Page 3300

069269_0225_SL.TXT

gggattcaaa gttgggatca aaacggtgaa gaaaagagag atcaatttcc caactccttc 120 agattgattt gatttcagtt gtgtataatt gatagtagcc gttccataga ataagacgac 180 aactatcagg tgagaagaac aggtggagaa ggctttagcc ctccctttgg ctgatgacaa 240 tttcagaatg ctggagataa ttttgccata ggagacaaca atcaacagaa atggaaccat 300 gacaattgcc actgcaatta tatagaccac aaattcattc acaagtgtgt ccccacaagc 360 tagcttgagt actgggggga tgtcacagaa gaaatgatta attgtgttag acccacaaaa 420 gggcagagag aaaatctggc atgtttgtcc aattacaaat ggaaatacac tgatccagga 480 gacagtcacc agttggacac agaccttgtg gttcatgatt agagggtagt acagagggtt 540 acaaatggcc atgtagcggt cataggccat cactgtcagg agaagacact ctgagcttcc 600 aaatgtgagg aaaaaaaaca tttgtgcagc acaggcaaag aaagaaatat ttcctttctg 660 agtcaatagg tccatgagca ttctgggcat tgtgactgtt acataacaga tttctaagaa 720 ggagagattg ccaagaaaaa aatacatggg ggtctggaga gcagagtcaa ttcttgttac 780 caatattatg atgctattgc acatcaggat agttaggtag atgactaaaa atatcccaaa 840 aagagtccag tggagattgg gactatcaga aaaccccaag agaacaaatt ccatcagtgt 900 agtaatattt gaaattcctg tttgcaattg attctccat 939

<210> 2964 <211> 313 <212> PRT <213> Felis catus <400> 2964

Met Glu Asn Gln Leu Gln Thr Gly Ile Ser Asn Ile Thr Thr Leu Met 1 5 10 15 Glu Phe Val Leu Leu Gly Phe Ser Asp Ser Pro Asn Leu His Trp Thr 20 25 30 Leu Phe Gly Ile Phe Leu Val Ile Tyr Leu Thr Ile Leu Met Cys Asn 35 40 45 Ser Ile Ile Ile Leu Val Thr Arg Ile Asp Ser Ala Leu Gln Thr Pro 50 55 60

Page 3301

069269_0225_SL.TXT

Met 65 Tyr Phe Phe Leu Gly Asn Leu Ser Phe Leu Glu Ile Cys Tyr Val 70 75 80 Thr Val Thr Met Pro Arg Met Leu Met Asp Leu Leu Thr Gln Lys Gly 85 90 95 Asn Ile Ser Phe Phe Ala Cys Ala Ala Gln Met Phe Phe Phe Leu Thr 100 105 110 Phe Gly Ser Ser Glu Cys Leu Leu Leu Thr Val Met Ala Tyr Asp Arg 115 120 125 Tyr Met Ala Ile Cys Asn Pro Leu Tyr Tyr Pro Leu Ile Met Asn His 130 135 140 Lys Val Cys Val Gln Leu Val Thr Val Ser Trp Ile Ser Val Phe Pro 145 150 155 160 Phe Val Ile Gly Gln Thr Cys Gln Ile Phe Ser Leu Pro Phe Cys Gly 165 170 175 Ser Asn Thr Ile Asn His Phe Phe Cys Asp Ile Pro Pro Val Leu Lys 180 185 190 Leu Ala Cys Gly Asp Thr Leu Val Asn Glu Phe Val Val Tyr Ile Ile 195 200 205 Ala Val Ala Ile Val Met Val Pro Phe Leu Leu Ile Val Val Ser Tyr 210 215 220 Gly Lys Ile Ile Ser Ser Ile Leu Lys Leu Ser Ser Ala Lys Gly Arg 225 230 235 240 Ala Lys Ala Phe Ser Thr Cys Ser Ser His Leu Ile Val Val Val Leu 245 250 255 Phe Tyr Gly Thr Ala Thr Ile Asn Tyr Thr Gln Leu Lys Ser Asn Gln 260 265 270

Page 3302

069269_0225_SL.TXT

Ser Glu Gly 275 Val Gly Lys Leu Ile Ser Leu Phe Phe Thr Val Leu Ile 280 285 Pro Thr Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys Asp Ile Thr 290 295 300 Val Ala Leu Arg Lys Leu Leu Thr Lys 305 310

<210> 2965 <211> 939 <212> DNA <213> Felis catus <400> 2965

cttcgttagt aattttctca gtgccaccat gatgtctttg ttcctcagag tatatataat 60 gggattcaaa gttgggatca aaacggtgta gaaaagagag atcaatttcc caactccttc 120 agattgattt ggtttcggtt gtaaatacgt gatggtagcc gttccataga ataagatgac 180 aactatcagg tgagaagaac aggtggagaa gactttagcc ctccctttgg ctgatgacaa 240 tttcagaatg ctggagataa ttttgccata ggagacaaca atcaacagaa atggaaccat 300 gacaaatatc actgcaacta cgtagactgc tatctcattc acaaatgtgt ccccacaagc 360 tagcttgagt actgggggga ggtcacagaa gaaatgatta attgtgttag acccacaaaa 420 gggcagagag aaaatctggc atgtttgccc aattacaact gggactccac tgatccagga 480 gacagtcacc agttggacac agaccttgtg gttcatgatt agaggatagt gcagagggtt 540 acaaatggcc acgtagcggt cataggccat cactgtcagg agaagacact ctgagcctcc 600 aaacataagg acaaaacaca tttgtgcagc acaggcaaag aaagaaatat ttcctttctg 660 agtcagtaag tccatgagca ttctggggat agtgactgtt acataacaga tttctaagaa 720 ggagagattg ccaagaaaaa aatacatggg ggtgtggaga gcagagtcaa ttcttgttac 780 caatattatg atgctattgc acatcaggat agttaggtag atgactaaaa atatcccaaa 840 aagagtccag tggagattgg gaatatcaga aaaacccaag agaacaaatt ccaccagttt 900 agtaacattt gaaattcctg tttttaatcg attctccat 939

Page 3303

069269_0225_SL.TXT <210> 2966 <211> 313 <212> PRT <213> Felis catus

<400> 2966 Thr Lys Leu 15 Val Met 1 Glu Asn Arg Leu Lys Thr Gly 5 Ile Ser 10 Asn Val Glu Phe Val Leu Leu Gly Phe Ser Asp Ile Pro Asn Leu His Trp Thr 20 25 30 Leu Phe Gly Ile Phe Leu Val Ile Tyr Leu Thr Ile Leu Met Cys Asn 35 40 45 Ser Ile Ile Ile Leu Val Thr Arg Ile Asp Ser Ala Leu His Thr Pro 50 55 60 Met Tyr Phe Phe Leu Gly Asn Leu Ser Phe Leu Glu Ile Cys Tyr Val 65 70 75 80 Thr Val Thr Ile Pro Arg Met Leu Met Asp Leu Leu Thr Gln Lys Gly 85 90 95 Asn Ile Ser Phe Phe Ala Cys Ala Ala Gln Met Cys Phe Val Leu Met 100 105 110 Phe Gly Gly Ser Glu Cys Leu Leu Leu Thr Val Met Ala Tyr Asp Arg 115 120 125 Tyr Val Ala Ile Cys Asn Pro Leu His Tyr Pro Leu Ile Met Asn His 130 135 140 Lys Val Cys Val Gln Leu Val Thr Val Ser Trp Ile Ser Gly Val Pro 145 150 155 160 Val Val Ile Gly Gln Thr Cys Gln Ile Phe Ser Leu Pro Phe Cys Gly 165 170 175 Ser Asn Thr Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Lys 180 185 190

Page 3304

069269_0225_SL.TXT

Leu Ala Cys Gly Asp Thr Phe Val Asn Glu Ile Ala Val Tyr Val Val 195 200 205 Ala Val Ile Phe Val Met Val Pro Phe Leu Leu Ile Val Val Ser Tyr 210 215 220 Gly Lys Ile Ile Ser Ser Ile Leu Lys Leu Ser Ser Ala Lys Gly Arg 225 230 235 240 Ala Lys Val Phe Ser Thr Cys Ser Ser His Leu Ile Val Val Ile Leu 245 250 255 Phe Tyr Gly Thr Ala Thr Ile Thr Tyr Leu Gln Pro Lys Pro Asn Gln 260 265 270 Ser Glu Gly Val Gly Lys Leu Ile Ser Leu Phe Tyr Thr Val Leu Ile 275 280 285 Pro Thr Leu Asn Pro Ile Ile Tyr Thr Leu Arg Asn Lys Asp Ile Met 290 295 300 Val Ala Leu Arg Lys Leu Leu Thr Lys

305 310 <210> 2967 <211> 933 <212> DNA <213> Felis catus <400> 2967 ttaaggtaac aattttctca aggccatcat ggcatcctta tttctcagag tgtatatcat aggattaaac attggggtga caatggtata gaaaagagag agaaacttgt ctgctctgga agaatgttta gacttgggcc gtaaatatgt gatgattgca gatccaaaga acatcgccac aactgtgata tgagacgagc aggtggagaa agctttggtt cgtcctgttg ctgatggcaa cctcagaatg gtggagatga ttttgatgta ggatccaagt atcaacagaa aggggatcgt aacaaacagc acagcgactg taaagactaa catctcattc aggaatgtgt ccccacaggc

120

180

240

300

360

Page 3305

069269_0225_SL.TXT

caacttgagt agtggaggga tgtcacagaa gaagtgattg atttggttag acccacaaaa 420 tggcagagag aaaatttggt atgtctgccc tgtctccact ggaactccag tgatccagca 480 ggccactacc atctggacac agaccttgtg gttcataact aaaggatagt gcagagggtt 540 acaaatggcc acgtagcggt cataggccat cactgtcaga aggaggcact ctatgtttcc 600 aagcgtaagg acaaaaccca tttgtgttgc acaggcaaac aaagaaatat ttcttttctg 660 agtccaaagg tttgtgagca ttctgggaag agtgacagat acaaaacaga tttccaagaa 720 ggaaaaatta ctaaggaaaa aatacatggg cgtctgaaga gcctggtcaa ccctgactat 780 gagaacaatg atgccatttc ccatcagaat tatcacatag acaaagaaaa atattacaaa 840 aagaaacatt tgaagattgg gaatatcaga aaatcccaaa agaacaaatt ccatcactga 900 agtgagattt <210> 2968 <211> 310 <212> PRT <213> Felis <400> 2968 acttctgctg tttttttctc catus cat 933 Met Glu Lys Lys Thr Ala Glu Val Asn Leu Thr Ser Val Met Glu Phe 1 5 10 15 Val Leu Leu Gly Phe Ser Asp Ile 20 Pro Asn Leu 25 Gln Met Phe Leu Phe 30 Val Ile Phe 35 Phe Phe Val Tyr Val 40 Ile Ile Leu Met Gly Asn Gly Ile 45 Ile Val Leu 50 Ile Val Arg Val Asp 55 Gln Ala Leu Gln Thr Pro Met Tyr 60 Phe Phe Leu Ser Asn Phe Ser Phe Leu Glu Ile Cys Phe Val Ser Val 65 70 75 80 Thr Leu Pro Arg Met Leu Thr Asn 85 Leu Trp Thr 90 Gln Lys Arg Asn Ile 95 Ser Leu Phe Ala Cys Ala Thr Gln Met Gly Phe Val Leu Thr Leu Gly

Page 3306

100

069269_0225_SL.TXT 105 110

Asn Ile Glu Cys Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys Asn Pro Leu His Tyr Pro Leu Val Met Asn His Lys Val 130 135 140 Cys Val Gln Met Val Val Ala Cys Trp Ile Thr Gly Val Pro Val Glu 145 150 155 160 Thr Gly Gln Thr Tyr Gln Ile Phe Ser Leu Pro Phe Cys Gly Ser Asn 165 170 175 Gln Ile Asn His Phe Phe Cys Asp Ile Pro Pro Leu Leu Lys Leu Ala 180 185 190 Cys Gly Asp Thr Phe Leu Asn Glu Met Leu Val Phe Thr Val Ala Val 195 200 205 Leu Phe Val Thr Ile Pro Phe Leu Leu Ile Leu Gly Ser Tyr Ile Lys 210 215 220 Ile Ile Ser Thr Ile Leu Arg Leu Pro Ser Ala Thr Gly Arg Thr Lys 225 230 235 240 Ala Phe Ser Thr Cys Ser Ser His Ile Thr Val Val Ala Met Phe Phe 245 250 255 Gly Ser Ala Ile Ile Thr Tyr Leu Arg Pro Lys Ser Lys His Ser Ser 260 265 270 Arg Ala Asp Lys Phe Leu Ser Leu Phe Tyr Thr Ile Val Thr Pro Met 275 280 285 Phe Asn Pro Met Ile Tyr Thr Leu Arg Asn Lys Asp Ala Met Met Ala 290 295 300 Leu Arg Lys Leu Leu Pro

Page 3307

069269_0225_SL.TXT

305

310 <210> 2969 <211> 961 <212> DNA <213> Felis catus <400> 2969 atggaaaatg tgactgaagt cacgacattt atattgatgg gcttcacaaa tgattttaag 60 ctgcaagttt tcctattttt cctatttcta gcaatctatc tttttacgat gatgggaaac 120 ttgggaatgg ttttattggt cattggggat tctcggctcc acaaccctat gtactatttt 180 ctgagtgtct tatcattcct ggatgcctgc tactcttcag ctgtcacccc aaaaatgtta 240 gtcaatttct tgtcagagaa taaagccatt tcattccttg gatgtgcagc acagatgttt 300 ctctttgtta ctttcggaac cacggaatgt tttatcttag ctgcaatggc ttatgatcgc 360 tatgtagcca tctacaaccc tctcctgtat tcagttagaa tgtcacccag ggtctacgtg 420 ccgctcatag tttcctgcta tgttggtggc tttctgcatg ctactttaca caccgtggct 480 acctttcgtc tatccttctg tgcatccaat gaaattaaac atgtcttttg tgacatccct 540 cctcttctcg ctatttcttg ttctgacact cacataaacc aactgctagt cttctacttt 600 gcgggatcta ttgagatatc cactatcctc atagtcctgg tctcctatgg ttttattctg 660 ttggccattc tgaggatgca ttccgctgaa gggaggcgga aggtcttttc cacgtgtggc 720 tctcacctaa ctggagtatc aatttttcac ggtacggttc tcttcatgta tgtgagacct 780 aattccagct atgctttgga tcatgatatg atagtgtcag tattttacac gattgtgatt 840 cctatgctga atcccatcat ctatagtttg aggaacaaag atgtgaaaga tgcaatgaaa 900 agagtgtttg gtaaaagctg gtttgccaat aaagtatact tttcacacta aacgttaaat 960 t 961 <210> 2970 <211> 316 <212> PRT <213> Felis catus <400> 2970

Met Glu Asn Val Thr Glu Val Thr Thr Phe Ile Leu Met Gly Phe Thr 1 5 10 15

Page 3308

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Asn Asp Phe Lys 20 Leu Gln Val Phe Leu Phe Phe Leu Phe Leu Ala Ile 25 30 Tyr Leu Phe Thr Met Met Gly Asn Leu Gly Met Val Leu Leu Val Ile 35 40 45 Gly Asp Ser Arg Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu 50 55 60 Ser Phe Leu Asp Ala Cys Tyr Ser Ser Ala Val Thr Pro Lys Met Leu 65 70 75 80 Val Asn Phe Leu Ser Glu Asn Lys Ala Ile Ser Phe Leu Gly Cys Ala 85 90 95 Ala Gln Met Phe Leu Phe Val Thr Phe Gly Thr Thr Glu Cys Phe Ile 100 105 110 Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Tyr Asn Pro Leu 115 120 125 Leu Tyr Ser Val Arg Met Ser Pro Arg Val Tyr Val Pro Leu Ile Val 130 135 140 Ser Cys Tyr Val Gly Gly Phe Leu His Ala Thr Leu His Thr Val Ala 145 150 155 160 Thr Phe Arg Leu Ser Phe Cys Ala Ser Asn Glu Ile Lys His Val Phe 165 170 175 Cys Asp Ile Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Ile 180 185 190 Asn Gln Leu Leu Val Phe Tyr Phe Ala Gly Ser Ile Glu Ile Ser Thr 195 200 205 Ile Leu Ile Val Leu Val Ser Tyr Gly Phe Ile Leu Leu Ala Ile Leu 210 215 220

Page 3309

069269_0225_SL.TXT

Arg 225 Met His Ser Ala Glu Gly Arg Arg Lys Val Phe Ser Thr Cys Gly 230 235 240 Ser His Leu Thr Gly Val Ser Ile Phe His Gly Thr Val Leu Phe Met 245 250 255 Tyr Val Arg Pro Asn Ser Ser Tyr Ala Leu Asp His Asp Met Ile Val 260 265 270 Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Met Lys Arg Val Phe Gly 290 295 300 Lys Ser Trp Phe Ala Asn Lys Val Tyr Phe Ser His 305 310 315

<210> 2971 <211> 957 <212> DNA <213> Felis catus <400> 2971

tcatattaca atccattttg gtaagaattt tttgagtgcc accaaaacat ctttgtttct 60 caaacaatat attatgggat taaacattgg tgtcacaatg ctgtaaaaga gagaaagaaa 120 tttgtccatt cctgttgaat ggctggactt tggtctcaaa tacgaaatga tgcctgatcc 180 aaagaataaa gccacaacca caaggtggga agaacacgta gagaatgcct tggctcgccc 240 agcggctgat ggcagcttca ggatggttga gattattttc acataagatc caagaatcaa 300 cataaaagga atagtgacaa ctagaacagc aactgtataa accaatatct caatcgtaaa 360 agtatcccca caggcaagct taagtattgg aggtatgtca cagaaaaagt gattcaactg 420 attggacccg cagaagggtt gagagaagat taggtaggtg aaccctatgt gtactggaat 480 tccagtgatc caacagccag ctgccaattg gatacacagc ctactgttca tgatgagagg 540 gtagagtaag gggttgcaaa tggcgacata cctgtcgtaa gccattgcag tcaaaataaa 600

Page 3310

069269_0225_SL.TXT

gcactcggtg gctccaaaga ccagaaagaa atacatttgt gtagcacagg ccagaaagga 660 aatgcttcta ctttgtctac aaagatctgt taataatctg gggacagtga ctgacacata 720 acatatttcc aaggaagaaa agttcccaag gaaaaaatac atgggagtcc ggagggaggg 780 atcaatctgg gttattatga taatgaggct atttcccatc agaataatca cataaattat 840 caaaaacacc ccaaaaagaa actcttggag gtcaggaaca tcagaaaagc caagcaggat 900 gaaatccatt aatgtagtgt gattccctcc tggaggatat tgtcctttag attccat 957

<210> 2972 <211> 318 <212> PRT <213> Felis catus

<400> 2972 Gln Tyr Pro Pro Gly Gly Asn His Thr Thr Leu Met 1 Glu Ser Lys Gly 5 10 15 Met Asp Phe Ile Leu Leu Gly Phe Ser Asp Val Pro Asp Leu Gln Glu 20 25 30 Phe Leu Phe Gly Val Phe Leu Ile Ile Tyr Val Ile Ile Leu Met Gly 35 40 45 Asn Ser Leu Ile Ile Ile Ile Thr Gln Ile Asp Pro Ser Leu Arg Thr 50 55 60 Pro Met Tyr Phe Phe Leu Gly Asn Phe Ser Ser Leu Glu Ile Cys Tyr 65 70 75 80 Val Ser Val Thr Val Pro Arg Leu Leu Thr Asp Leu Cys Arg Gln Ser 85 90 95 Arg Ser Ile Ser Phe Leu Ala Cys Ala Thr Gln Met Tyr Phe Phe Leu 100 105 110 Val Phe Gly Ala Thr Glu Cys Phe Ile Leu Thr Ala Met Ala Tyr Asp 115 120 125

Arg Tyr Val Ala Ile Cys Asn Pro Leu Leu Tyr Pro Leu Ile Met Asn Page 3311

130 135 069269_0225_SL.TXT 140 Ser Arg Leu Cys Ile Gln Leu Ala Ala Gly Cys Trp Ile Thr Gly Ile 145 150 155 160 Pro Val His Ile Gly Phe Thr Tyr Leu Ile Phe Ser Gln Pro Phe Cys 165 170 175 Gly Ser Asn Gln Leu Asn His Phe Phe Cys Asp Ile Pro Pro Ile Leu 180 185 190 Lys Leu Ala Cys Gly Asp Thr Phe Thr Ile Glu Ile Leu Val Tyr Thr 195 200 205 Val Ala Val Leu Val Val Thr Ile Pro Phe Met Leu Ile Leu Gly Ser 210 215 220 Tyr Val Lys Ile Ile Ser Thr Ile Leu Lys Leu Pro Ser Ala Ala Gly 225 230 235 240 Arg Ala Lys Ala Phe Ser Thr Cys Ser Ser His Leu Val Val Val Ala 245 250 255 Leu Phe Phe Gly Ser Gly Ile Ile Ser Tyr Leu Arg Pro Lys Ser Ser 260 265 270 His Ser Thr Gly Met Asp Lys Phe Leu Ser Leu Phe Tyr Ser Ile Val 275 280 285 Thr Pro Met Phe Asn Pro Ile Ile Tyr Cys Leu Arg Asn Lys Asp Val 290 295 300 Leu Val Ala Leu Lys Lys Phe Leu Pro Lys Trp Ile Val Ile 305 310 315

<210> 2973 <211> 937 <212> DNA <213> Felis catus

Page 3312

069269_0225_SL.TXT <400> 2973

tagttcaaaa aatttacaaa gcatatcaga caaaaggagg gatcctcctc ttggtagtga 60 aattccataa agccttcttt acttcctcat ttctaaggct gtagatcagg ggattcaaca 120 tagggatcac tactgtgtag aacacagaag ccactttgtc ctgacccaag gagtagctgg 180 aactaggtct cagataggta tagatggcgg tggcatagaa cagagttatc gctgtcaagt 240 gagaggcaca cgtggagacg gctttgtgcc tcccctgccg tgaatgcacg tggaagacag 300 agaagagaat gtaggagtag gaggtgagga tgatcagcag agtcccggcc agattcgcac 360 cagcaaacgt ggaaatgata ccctcggtaa ggtgtgtgtc agagcacgag agcctaaaga 420 gtggagggct gtcacagaag aagtggtgaa tgacattgga accacagaat ggcaagctgc 480 ctacataact cgtgttaacc atggagttca agaatcctgc tgtaaaagcc cctgctgcca 540 ttttgaggca gactgtcctg gacatgatca aagagtaaag gagggggttg catatggcca 600 cgtaacggtc ataggccatt aagccaaaga ggatggcttc ggttgtggcc aaggcgataa 660 agaagtacaa ttgcaggaag cagcctgcga aggagatggt tttcgtctct gacagtaagt 720 ctaccagcat ctttggggtg atggcggagg aataacaaac atccacaaag gacaggttag 780 ccaggaagaa atacatgggt gtgtgaagtc gggaatcagt gccgattaag aggatcatcc 840 caacattccc caaaactgta agggcgtaaa tcccaaagaa aagcagaaag aggatgatcc 900 gtaactccat ggtgtctgct aatcccaaca ggatgaa 937

<210> 2974 <211> 303 <212> PRT <213> Felis catus <400> 2974

Phe 1 Ile Leu Leu Gly Leu Ala Asp Thr Met Glu Leu Arg Ile Ile Leu 5 10 15 Phe Leu Leu Phe Phe Gly Ile Tyr Ala Leu Thr Val Leu Gly Asn Val 20 25 30 Gly Met Ile Leu Leu Ile Gly Thr Asp Ser Arg Leu His Thr Pro Met 35 40 45

Page 3313

Tyr Phe 50 Phe Leu Ala Asn Leu 55 069269_0225_SL.TXT Ser Phe Val Asp Val Cys 60 Tyr Ser Ser Ala Ile Thr Pro Lys Met Leu Val Asp Leu Leu Ser Glu Thr Lys Thr 65 70 75 80 Ile Ser Phe Ala Gly Cys Phe Leu Gln Leu Tyr Phe Phe Ile Ala Leu 85 90 95 Ala Thr Thr Glu Ala Ile Leu Phe Gly Leu Met Ala Tyr Asp Arg Tyr 100 105 110 Val Ala Ile Cys Asn Pro Leu Leu Tyr Ser Leu Ile Met Ser Arg Thr 115 120 125 Val Cys Leu Lys Met Ala Ala Gly Ala Phe Thr Ala Gly Phe Leu Asn 130 135 140 Ser Met Val Asn Thr Ser Tyr Val Gly Ser Leu Pro Phe Cys Gly Ser 145 150 155 160 Asn Val Ile His His Phe Phe Cys Asp Ser Pro Pro Leu Phe Arg Leu 165 170 175 Ser Cys Ser Asp Thr His Leu Thr Glu Gly Ile Ile Ser Thr Phe Ala 180 185 190 Gly Ala Asn Leu Ala Gly Thr Leu Leu Ile Ile Leu Thr Ser Tyr Ser 195 200 205 Tyr Ile Leu Phe Ser Val Phe His Val His Ser Arg Gln Gly Arg His 210 215 220 Lys Ala Val Ser Thr Cys Ala Ser His Leu Thr Ala Ile Thr Leu Phe 225 230 235 240 Tyr Ala Thr Ala Ile Tyr Thr Tyr Leu Arg Pro Ser Ser Ser Tyr Ser 245 250 255

Page 3314

069269_0225_SL.TXT Leu Gly Gln Asp Lys Val Ala Ser Val Phe Tyr Thr Val Val Ile Pro 260 265 270

Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Glu Glu Val Lys Lys 275 280 285

Ala Leu Trp Asn Phe Thr Thr Lys Arg Arg Ile Pro Pro Phe Val 290 295 300

<210> 2975 <211> 939 <212> DNA <213> Felis catus <400> 2975

atgttggaga gtaattatac catgccaact gagtttcttc ttgttggatt cacagattat 60 ttgcctctca gggtcacact cttcttggta tttcttatag tctatacact aactgtggtg 120 ggaaatctgg gtttaataat cttagttcat atcaatccga gccttcaaac ccccatgtat 180 tattttctta gcaacctgtc tttcttagac atctgctatt ctaccgcgat cgctcctaaa 240 atgctggtga attttttagc atccaggaaa agcatctctc cctatggctg tgcactacaa 300 atgtttttct ttggttgctt tgctgatgct gagtgcctca ttctggcagc aatggcctat 360 gaccgctatg cagccatctg taacccattg ctctattcta cccttatgtc gaggagagtc 420 tgtatctgct tcgttgtgtt ggcgtacttc agcgggagta tgacttccat ggtacatgtc 480 tgcctcacat tcaggctgtc attttgtggc tctaatattg tcaatcattt cttctgtgat 540 atcccacctc ttctggcttt atcatgcacg gacatccatg tcaatgagct tctgctcttt 600 gccttatgtg gtttcatcca gaccagcact tttgtggtca tatttatctc ttacttctgt 660 atcctcatca ctgttttgag cattaaatcc tcagggggca ggagcaaaac gttctccact 720 tgtacttccc atttcatagc ggtctccttg ttctacggaa cactcctgtt tatgtactta 780 cgtcccacca ctgactattc cctggacact gacaaggtag ttgcagtgtt ttatactgtg 840 gtctttccca tgtttaaccc aataatatac agtttcagaa acagggatgt aaaaaatgcc 900 ctcaaaaagc tattagaaag aaactggact ttcaaatga 939

<210> 2976

Page 3315

069269_0225_SL.TXT <211> 312 <212> PRT <213> Felis catus

<400> 2976 Asn Tyr Thr Met Pro Thr Glu Phe Leu Leu Val Gly Met 1 Leu Glu Ser 5 10 15 Phe Thr Asp Tyr Leu Pro Leu Arg Val Thr Leu Phe Leu Val Phe Leu 20 25 30 Ile Val Tyr Thr Leu Thr Val Val Gly Asn Leu Gly Leu Ile Ile Leu 35 40 45 Val His Ile Asn Pro Ser Leu Gln Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Ser Thr Ala Ile Ala Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Ala Ser Arg Lys Ser Ile Ser Pro Tyr Gly 85 90 95 Cys Ala Leu Gln Met Phe Phe Phe Gly Cys Phe Ala Asp Ala Glu Cys 100 105 110 Leu Ile Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ser Thr Leu Met Ser Arg Arg Val Cys Ile Cys Phe 130 135 140 Val Val Leu Ala Tyr Phe Ser Gly Ser Met Thr Ser Met Val His Val 145 150 155 160 Cys Leu Thr Phe Arg Leu Ser Phe Cys Gly Ser Asn Ile Val Asn His 165 170 175 Phe Phe Cys Asp Ile Pro Pro Leu Leu Ala Leu Ser Cys Thr Asp Ile 180 185 190

Page 3316

069269_0225_SL.TXT

His Val Asn Glu Leu Leu Leu Phe Ala Leu Cys Gly Phe Ile Gln Thr 195 200 205 Ser Thr Phe Val Val Ile Phe Ile Ser Tyr Phe Cys Ile Leu Ile Thr 210 215 220 Val Leu Ser Ile Lys Ser Ser Gly Gly Arg Ser Lys Thr Phe Ser Thr 225 230 235 240 Cys Thr Ser His Phe Ile Ala Val Ser Leu Phe Tyr Gly Thr Leu Leu 245 250 255 Phe Met Tyr Leu Arg Pro Thr Thr Asp Tyr Ser Leu Asp Thr Asp Lys 260 265 270 Val Val Ala Val Phe Tyr Thr Val Val Phe Pro Met Phe Asn Pro Ile 275 280 285 Ile Tyr Ser Phe Arg Asn Arg Asp Val Lys Asn Ala Leu Lys Lys Leu 290 295 300 Leu Glu Arg Asn Trp Thr Phe Lys

305 310 <210> 2977 <211> 929 <212> DNA <213> Felis catus <400> 2977

atggcaggtt ggaaccagac aggggtgaag gaattccttc tggtaggttt aactgaaaac 60 cctaatttgc agatccctct ctttttcctt ttctccctta tttattccat cactctggca 120 ggtaattggg ggatgattat cttgatctgg ttaaataccc aacttcatac gccaatgtac 180 tttttcctta gcaacctctc tttttgtgat atctgctact ctactgtctt tgctccaaag 240 atgttggtca attttctatc aaaacacaaa gctagcacat tttctggttg tgttctacag 300 agtttctttt ttgcagttta tgtaaccaca gagggcatcc ttctgtctat gatggcttat 360 gaccgctatg tggcaatagc taatcccttg tcatatacac tcataatgac ccaaaaggtt 420

Page 3317

069269_0225_SL.TXT

tgtatgcaga tggtccttgc gtcatacttg ggtgggctca ttaattcgtt gacacacaca 480 ataggtttgc tcaagctaga tttctgtggt cctaacatcg tgaatcatta tttctgtgac 540 attccccctc ttctgagact ctcttgctct gatgcccatg acaatgagat gctactttta 600 gttttctctg gggtcattgc aatgttcact ttcactatca tcatggtctc ttatacgtgc 660 atcatcattg ccatccagag aatccgctca gctgagggga ggcacaaagc cttctccact 720 tgcgcctctc acctcactgc tgtgacctta ttctatgggt ctgtaacctt tagttacatc 780 cagccaagtt ctcagtattc tctggaacag gagaaagtct ctgctgtgtt ttatacattg 840 gttatcccca tgctgaaccc actgatttat agcttacgca ataaggatgt aaaagaggca 900 gcaaaaaggt caatgtggtg gaagagaac 929

<210> 2978 <211> 310 <212> PRT <213> Felis catus

<400> 2978 Gln Thr Gly Val Lys Glu Phe Leu Leu Val Gly Met Ala 1 Gly Trp Asn 5 10 15 Leu Thr Glu Asn Pro Asn Leu Gln Ile Pro Leu Phe Phe Leu Phe Ser 20 25 30 Leu Ile Tyr Ser Ile Thr Leu Ala Gly Asn Trp Gly Met Ile Ile Leu 35 40 45 Ile Trp Leu Asn Thr Gln Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Cys Asp Ile Cys Tyr Ser Thr Val Phe Ala Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Ser Lys His Lys Ala Ser Thr Phe Ser Gly 85 90 95 Cys Val Leu Gln Ser Phe Phe Phe Ala Val Tyr Val Thr Thr Glu Gly 100 105 110

Page 3318

069269_0225_SL.TXT

Ile Leu Leu 115 Ser Met Met Ala Tyr Asp Arg Tyr Val Ala Ile Ala Asn 120 125 Pro Leu Ser Tyr Thr Leu Ile Met Thr Gln Lys Val Cys Met Gln Met 130 135 140 Val Leu Ala Ser Tyr Leu Gly Gly Leu Ile Asn Ser Leu Thr His Thr 145 150 155 160 Ile Gly Leu Leu Lys Leu Asp Phe Cys Gly Pro Asn Ile Val Asn His 165 170 175 Tyr Phe Cys Asp Ile Pro Pro Leu Leu Arg Leu Ser Cys Ser Asp Ala 180 185 190 His Asp Asn Glu Met Leu Leu Leu Val Phe Ser Gly Val Ile Ala Met 195 200 205 Phe Thr Phe Thr Ile Ile Met Val Ser Tyr Thr Cys Ile Ile Ile Ala 210 215 220 Ile Gln Arg Ile Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Ser Val Thr 245 250 255 Phe Ser Tyr Ile Gln Pro Ser Ser Gln Tyr Ser Leu Glu Gln Glu Lys 260 265 270 Val Ser Ala Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Ala Lys Arg Ser 290 295 300 Met Trp Trp Lys Arg Thr

305 310

Page 3319

069269_0225_SL.TXT <210> 2979 <211> 939 <212> DNA <213> Felis catus <400> 2979

atggctgatg ataatttgac attggttaca gagtttatcc ttttgggact gacagaccgt 60 cctgaactga aagtggtcct ctttacgccg ttccttctga tctacaccat atctttggtg 120 gggaatatag gaatgctctt tctaatccaa ataactccca aactccacac acccatgtat 180 catttcctta gctgcctgtc atttgttgat gcctgttatt cgtccgtctt tgcaccgaaa 240 atgctgctca acttctttgc tgaacgggag acaatctcat tctctgcatg catcgtgcaa 300 tattttttct ttgtgtcact ccttaccact gagggcttct tgctggcggc aatggcttat 360 gaccgctacg tggccatcgt gaacccttta ctttatacag tggcgatgac taaaatagtt 420 tgcgttgtcc tggtcattgg gtcatgtgta ggaggcttaa tcaactcgtt gacacacaca 480 attggcttgg tgaaattgtc tttctgtggg ccaaacatca tcagtcactt cttctgtgac 540 cttcccccac tgttgaagct gtcgtgttct gacacgtccc tgaatgaact gttgctttta 600 atcttttctg gaattattgc catcgtcact ttcttgactg tgatgatctc ctacatcttc 660 attgttgccg ccatcctcag gatccgctca gcagcaggaa gacaaaaagc cttctctacc 720 tgtgcttcgc atctaacggc cgtgacttta ttctatggct ctataagctt tagttacatt 780 caaccaagtt cccaatattc cttagaacaa gagaaggtgg tgtctgtgct ttataccttg 840 gtgattccta tgttaaaccc aatgatttac agcctgagga ataaggaagt aaaggatgcc 900 gtgaaaaagg ctatagaaat gaaatacttc ccttgttaa 939

<210> 2980 <211> 312 <212> PRT <213> Felis catus <400> 2980

Met Ala Asp Asp Asn Leu Thr Leu Val Thr Glu Phe Ile Leu Leu Gly

1 5 10 15

Leu Thr Asp Arg Pro Glu Leu Lys Val Val Leu Phe Thr Pro Phe Leu

Page 3320

069269_0225_SL.TXT 25 30

Leu Ile Tyr 35 Thr Ile Ser Leu Val Gly Asn Ile Gly Met Leu Phe Leu 40 45 Ile Gln Ile Thr Pro Lys Leu His Thr Pro Met Tyr His Phe Leu Ser 50 55 60 Cys Leu Ser Phe Val Asp Ala Cys Tyr Ser Ser Val Phe Ala Pro Lys 65 70 75 80 Met Leu Leu Asn Phe Phe Ala Glu Arg Glu Thr Ile Ser Phe Ser Ala 85 90 95 Cys Ile Val Gln Tyr Phe Phe Phe Val Ser Leu Leu Thr Thr Glu Gly 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Val Asn 115 120 125 Pro Leu Leu Tyr Thr Val Ala Met Thr Lys Ile Val Cys Val Val Leu 130 135 140 Val Ile Gly Ser Cys Val Gly Gly Leu Ile Asn Ser Leu Thr His Thr 145 150 155 160 Ile Gly Leu Val Lys Leu Ser Phe Cys Gly Pro Asn Ile Ile Ser His 165 170 175 Phe Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190 Ser Leu Asn Glu Leu Leu Leu Leu Ile Phe Ser Gly Ile Ile Ala Ile 195 200 205 Val Thr Phe Leu Thr Val Met Ile Ser Tyr Ile Phe Ile Val Ala Ala 210 215 220 Ile Leu Arg Ile Arg Ser Ala Ala Gly Arg Gln Lys Ala Phe Ser Thr

Page 3321

0 6926 9_02 25_S L.TX T 225 230 235 240 Cys Ala Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Ser Ile Ser 245 250 255 Phe Ser Tyr Ile Gln Pro Ser Ser Gln Tyr Ser Leu Glu Gln Glu Lys 260 265 270 Val Val Ser Val Leu Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Val Lys Lys Ala 290 295 300 Ile Glu Met Lys Tyr Phe Pro Cys

305 310 <210> 2981 <211> 934 <212> DNA <213> Felis catus <400> 2981

atggccaaca gaaatgtcag tgtggtaact gaattcatcc tccttgggct gaccgataac 60 cctgaactga atactgtcct ttttgtgctg tttctctcca tttattttgt caccgtggtg 120 ggcaatgttt ggattatagc aataatctgg gctagtaccc agctccattc ccccaaatac 180 ttcttccttt gccagctggc tttcttggat ttctgctatt cgtcagtctt tattcctaaa 240 atgttggtga attacctagc aggacagaaa gtcatctcct atcacggttg cctccttcag 300 tattcctttg tcagcatgat cctgaccact gaatgtttcc tgctggcggc catggcctat 360 gaccgctatg tcgccatttg ccgcccgctt cactacaaag gcctcatgac ccccacgttc 420 tgcacccact tggtggctgc ttgctacctg ctaggttctg ccagctcact cacccacctg 480 agaggcttgc tcagcctgtc tttctgtggg cccaacatca tcaaccatta cttctgtgac 540 atcccactgc tctttcaact gtcctgttcg gacacccaac acaacaagat tttacttacc 600 gtcctctctg gaatgacatc ggtgaccacc ttcctgatgg tggttggttc ctatgtggga 660 atcctgctca ctgtcctgaa gtcaccctcc acaaggagca gatataaagc gttctccacg 720

Page 3322

069269_0225_SL.TXT

tgtgtatctc acctaacagt agtgactctc ttctacggaa cagtgatatt tacttatctg 780 ggaagcagtt ccagctccgc accagataga gccaaaatcc tgtccatgtt ttacaccctt 840 ttgctgccaa tcctaaattt cctgatatac agtgtgagaa acacagaggc caacgaagca 900 atgaaaagaa ttattgtgag aaaaatattt gctc 934 <210> 2982 <211> 312 <212> PRT <213> Felis catus

<220>

<221> MOD_RES <222> (312)..(312) <223> Any amino acid

<400> 2982 Val Ser Val Val Thr Glu Phe Ile Leu Leu Gly Met 1 Ala Asn Arg Asn 5 10 15 Leu Thr Asp Asn Pro Glu Leu Asn Thr Val Leu Phe Val Leu Phe Leu 20 25 30 Ser Ile Tyr Phe Val Thr Val Val Gly Asn Val Trp Ile Ile Ala Ile 35 40 45 Ile Trp Ala Ser Thr Gln Leu His Ser Pro Lys Tyr Phe Phe Leu Cys 50 55 60 Gln Leu Ala Phe Leu Asp Phe Cys Tyr Ser Ser Val Phe Ile Pro Lys 65 70 75 80 Met Leu Val Asn Tyr Leu Ala Gly Gln Lys Val Ile Ser Tyr His Gly 85 90 95 Cys Leu Leu Gln Tyr Ser Phe Val Ser Met Ile Leu Thr Thr Glu Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125

Page 3323

069269_0225_SL.TXT

Pro Leu 130 His Tyr Lys Gly Leu Met Thr Pro Thr Phe Cys Thr His Leu 135 140 Val Ala Ala Cys Tyr Leu Leu Gly Ser Ala Ser Ser Leu Thr His Leu 145 150 155 160 Arg Gly Leu Leu Ser Leu Ser Phe Cys Gly Pro Asn Ile Ile Asn His 165 170 175 Tyr Phe Cys Asp Ile Pro Leu Leu Phe Gln Leu Ser Cys Ser Asp Thr 180 185 190 Gln His Asn Lys Ile Leu Leu Thr Val Leu Ser Gly Met Thr Ser Val 195 200 205 Thr Thr Phe Leu Met Val Val Gly Ser Tyr Val Gly Ile Leu Leu Thr 210 215 220 Val Leu Lys Ser Pro Ser Thr Arg Ser Arg Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Val Ser His Leu Thr Val Val Thr Leu Phe Tyr Gly Thr Val Ile 245 250 255 Phe Thr Tyr Leu Gly Ser Ser Ser Ser Ser Ala Pro Asp Arg Ala Lys 260 265 270 Ile Leu Ser Met Phe Tyr Thr Leu Leu Leu Pro Ile Leu Asn Phe Leu 275 280 285 Ile Tyr Ser Val Arg Asn Thr Glu Ala Asn Glu Ala Met Lys Arg Ile 290 295 300 Ile Val Arg Lys Ile Phe Ala Xaa

305 310 <210> 2983 <211> 918

Page 3324

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 2983

atgactggga acaatttcac tgagatcact ctcttcatcc tctctggatt tgcaaatcac 60 ccggaactac aagtcagtct tttcttaatg ttcctcttta tttatctgtt cactgttctg 120 gggaaccttg ggctgatcat gttaatcaga attgactctc atcttcgcac acctatgtac 180 ttttttctta gcaacttagc atttattgac atattttatt cttccactgt aacacccaag 240 gcgctggtaa atttccaatc caaacagaaa accatctctt ttgttgcctg ctttgttcag 300 atgtactttt ttgtgggttt ggtgtgtagt gagtgttttc ttttgggatc aatggcctat 360 gaccgctacg tagcaatctg caatccctta ttgtactcag tggttatgtc ccggaaagtg 420 tgcaacgggc tgggagtcat gccatatgca ataggcttca cgaattctct gatatccgtc 480 tgtgtgataa gcagcttggc attctgtgat tccagcatca atcatttctt ctgtgatacc 540 acagctcttt tggccctgtc ttgtgcggat gcgttcagca cagaaatggt gatctttgtc 600 ttagctggga ccacccttct tagctctctg ctcatcatca cagtcactta cgttgccatc 660 atctcggcca ttctcaagat ccagtctgca gcaggcagac agaaggcctt ttccacctgt 720 gcttcccacc tcatgggcgt cactatcttc tatgggtccc tgattttcac atatttgcag 780 cctgataaca catcatccct gacccaggca caggtggcgt ccgtattcta taccatcgtc 840 attccgatgt tgaatccact gatctatagt ctgaggaaca gagatgtgaa aaatgctctc 900 ctgagagtca tgcataga 918

<210> 2984 <211> 306 <212> PRT <213> Felis catus

<400> 2984 Met Thr Gly Asn Asn Phe Thr Glu Ile Thr Leu Phe Ile Leu Ser Gly 1 5 10 15 Phe Ala Asn His Pro Glu Leu Gln Val Ser Leu Phe Leu Met Phe Leu 20 25 30 Phe Ile Tyr Leu Phe Thr Val Leu Gly Asn Leu Gly Leu Ile Met Leu Page 332 5

069269_0225_SL.TXT 40 45

Ile Arg 50 Ile Asp Ser His Leu Arg Thr Pro Met Tyr Phe Phe Leu Ser 55 60 Asn Leu Ala Phe Ile Asp Ile Phe Tyr Ser Ser Thr Val Thr Pro Lys 65 70 75 80 Ala Leu Val Asn Phe Gln Ser Lys Gln Lys Thr Ile Ser Phe Val Ala 85 90 95 Cys Phe Val Gln Met Tyr Phe Phe Val Gly Leu Val Cys Ser Glu Cys 100 105 110 Phe Leu Leu Gly Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ser Val Val Met Ser Arg Lys Val Cys Asn Gly Leu 130 135 140 Gly Val Met Pro Tyr Ala Ile Gly Phe Thr Asn Ser Leu Ile Ser Val 145 150 155 160 Cys Val Ile Ser Ser Leu Ala Phe Cys Asp Ser Ser Ile Asn His Phe 165 170 175 Phe Cys Asp Thr Thr Ala Leu Leu Ala Leu Ser Cys Ala Asp Ala Phe 180 185 190 Ser Thr Glu Met Val Ile Phe Val Leu Ala Gly Thr Thr Leu Leu Ser 195 200 205 Ser Leu Leu Ile Ile Thr Val Thr Tyr Val Ala Ile Ile Ser Ala Ile 210 215 220 Leu Lys Ile Gln Ser Ala Ala Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ser His Leu Met Gly Val Thr Ile Phe Tyr Gly Ser Leu Ile Phe

Page 3326

245 069269_0225_SL.TXT 250 255 Thr Tyr Leu Gln Pro Asp Asn Thr Ser Ser Leu Thr Gln Ala Gln Val 260 265 270 Ala Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Arg Asp Val Lys Asn Ala Leu Leu Arg Val Met 290 295 300

His Arg

305 <210> 2985 <211> 917 <212> DNA <213> Felis catus <400> 2985

agaaagaata acacacatgt gcctgacttc atccttatgg ggctgacaga ttctgaagag 60 gtccagctgg tccttttcat gctgtttctc ctgatatacc tggttactgt gctgggaaat 120 gcagggatga tattgatcat ccgcctggat ctccagcttc acacccccat gtattttttc 180 ctccgtcacc tgtcatttct tgacctcagt tactcaactg tcatcacacc taaaacctta 240 cagaacttac tgacttccac caagtatatt tcatacacga gctgcttcac ccagatgtcc 300 ttttttgtct tcttgggtgc cactgaatgt ttccttctct cctcaatggc ctatgatcgc 360 tatgtcgcta tctgcaatcc tctgcactac ccagtggtta tgtcctcaag gttctgctct 420 cacctcatct ttgggtccta tatgattggc tttgtggact cctttgtcaa tgggctttgc 480 atgagcaggt tgcatttctg cgactccaat gtaatccatc actttttctg tgacacaacc 540 ccagttttag ccttgtcttg cactgacaca catgacattg aaatcatgat atttattgtc 600 gctggctcca ctctaatggt gtctcttatc acaatatctg tgtcctatgt gtccattctg 660 tctactatcc tgaaaattac ttccacttca ggaaagaaaa aagccttctc tacttgtgcc 720 tctcatctcc tgggagtcgc catcttttat ggcactatga tttttactta tttaaagcca 780 agtaagtctt attccttggg aaaggatcaa gtggcttctg ttttttatac tattgtgatc 840

Page 3327

069269_0225_SL.TXT cccatgctga atccactcat ttatagtctc aggaacaaag aagtgaaaaa cgctctcctt agagtcatgt ggaaggg

900

917 <210> 2986 <211> 306 <212> PRT <213> Felis catus <400> 2986

Arg Lys 1 Asn Asn Thr His Val Pro Asp Phe Ile Leu Met Gly Leu Thr 5 10 15 Asp Ser Glu Glu Val Gln Leu Val Leu Phe Met Leu Phe Leu Leu Ile 20 25 30 Tyr Leu Val Thr Val Leu Gly Asn Ala Gly Met Ile Leu Ile Ile Arg 35 40 45 Leu Asp Leu Gln Leu His Thr Pro Met Tyr Phe Phe Leu Arg His Leu 50 55 60 Ser Phe Leu Asp Leu Ser Tyr Ser Thr Val Ile Thr Pro Lys Thr Leu 65 70 75 80 Gln Asn Leu Leu Thr Ser Thr Lys Tyr Ile Ser Tyr Thr Ser Cys Phe 85 90 95 Thr Gln Met Ser Phe Phe Val Phe Leu Gly Ala Thr Glu Cys Phe Leu 100 105 110 Leu Ser Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 115 120 125 His Tyr Pro Val Val Met Ser Ser Arg Phe Cys Ser His Leu Ile Phe 130 135 140 Gly Ser Tyr Met Ile Gly Phe Val Asp Ser Phe Val Asn Gly Leu Cys 145 150 155 160

Page 3328

069269_0225_SL.TXT

Met Ser Arg Leu His Phe Cys Asp Ser Asn 170 Val Ile His His Phe 175 Phe 165 Cys Asp Thr Thr Pro Val Leu Ala Leu Ser Cys Thr Asp Thr His Asp 180 185 190 Ile Glu Ile Met Ile Phe Ile Val Ala Gly Ser Thr Leu Met Val Ser 195 200 205 Leu Ile Thr Ile Ser Val Ser Tyr Val Ser Ile Leu Ser Thr Ile Leu 210 215 220 Lys Ile Thr Ser Thr Ser Gly Lys Lys Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Leu Gly Val Ala Ile Phe Tyr Gly Thr Met Ile Phe Thr 245 250 255 Tyr Leu Lys Pro Ser Lys Ser Tyr Ser Leu Gly Lys Asp Gln Val Ala 260 265 270 Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Leu Leu Arg Val Met Trp 290 295 300 Lys Gly 305 <210> 2987 <211> 931 <212> DNA <213> Felis catus <400> 2987 aattgataaa ccaatttttt tgaaacactc ttttcattgc ctcttttaca tctttgttcc ttaaactgta gatgatggga ttcagcatgg gaatcacaat gctgtaaaac attgacacta tcacgtcatg gtccagagca tagctggaac tcggtctcac atacatgaag aggatggttc

120

180

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catgatatat tgacactcca gttaggtgag agccacatgt agaaaagact ttccgcctcc 240 ctgcagcaga atgaatcttc agaatggcca acaaaatgaa accataggag atcagaactg 300 tcaggatagt gacgatctca atggagccca caaggtagaa gagcaggagc tggtttgtgt 360 gagtgtcaga acaagaaatg gcgaggagag gagggatgtc acaaaagaca tgtctaattt 420 cattggatgc gcagaaggac aggctgaatg tggccactgt gtgtacggaa gcatgcaaaa 480 tgccacccac gcaggaagca atgatgagtg gcacatagac tctgggtgac atgctcactg 540 agtacaggag agggttgtag atggcgacat agcggtcata tgccatcgca gccaagagaa 600 agcattctgt ggtcccaaag gtaacagcca gaaacatctg tgttgcacat ccaaggaatg 660 aaatgatttt attctttgac atgaaatcta ctaacatatt tggagtaata actgaggaaa 720 aacaagcatc cacagatgat aacacactta gaaaatagta catgggattg tggagccggg 780 aatccccaat gactaatgaa actaaaacca aattccccat catagtaaag aggtagattg 840 ctagaaacag gaagaataag attgtctgca gctcaagctt atctgtgaag cccttcagta 900 caaatatggt gacttccgtg tgattcttca t 931

<210> 2988 <211> 311 <212> PRT <213> Felis catus <220>

<221> MOD RES

<222> (311) .(311) <223> Any amino acid <400> 2988 Met Lys Asn His Thr Glu Val Thr Ile Phe Val Leu Lys Gly Phe Thr 1 5 10 15 Asp Lys Leu Glu Leu Gln Thr Ile Leu Phe Phe Leu Phe Leu Ala Ile 20 25 30 Tyr Leu Phe Thr Met Met Gly Asn Leu Val Leu Val Ser Leu Val Ile 35 40 45 Gly Asp Ser Arg Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu

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50 55 60

Ser 65 Ser Val Asp Ala Cys Phe Ser Ser Val Ile Thr Pro Asn Met Leu 80 70 75 Val Asp Phe Met Ser Lys Asn Lys Ile Ile Ser Phe Leu Gly Cys Ala 85 90 95 Thr Gln Met Phe Leu Ala Val Thr Phe Gly Thr Thr Glu Cys Phe Leu 100 105 110 Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Tyr Asn Pro Leu 115 120 125 Leu Tyr Ser Val Ser Met Ser Pro Arg Val Tyr Val Pro Leu Ile Ile 130 135 140 Ala Ser Cys Val Gly Gly Ile Leu His Ala Ser Val His Thr Val Ala 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys Ala Ser Asn Glu Ile Arg His Val Phe 165 170 175 Cys Asp Ile Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Thr 180 185 190 Asn Gln Leu Leu Leu Phe Tyr Leu Val Gly Ser Ile Glu Ile Val Thr 195 200 205 Ile Leu Thr Val Leu Ile Ser Tyr Gly Phe Ile Leu Leu Ala Ile Leu 210 215 220 Lys Ile His Ser Ala Ala Gly Arg Arg Lys Val Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Gly Val Ser Ile Tyr His Gly Thr Ile Leu Phe Met 245 250 255

Tyr Val Arg Pro Ser Ser Ser Tyr Ala Leu Asp His Asp Val Ile Val Page 3331

260

069269_0225_SL.TXT 265 270

Ser Met Phe Tyr Ser Ile Val Ile Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Met Lys Arg Val Phe Gln 290 295 300 Lys Asn Trp Phe Ile Asn Xaa

305 310 <210> 2989 <211> 939 <212> DNA <213> Felis catus <400> 2989 tgaaaatgta ttttacttag gaaccaattt ttaccaattt tttcattgct tcttttacat 60 ctttgttcct taaactgtag atgatgggat tcagcatggg aatcacaatc gtgtaaaatg 120 ttgagactat catgtcatgg tccagagcat agctggaact cggtctcacg tacgtgaaga 180 ggatggttcc atgatatatt gacactccgg ttaggtgaga gccacatgta gaaaagactt 240 tctgcctccc tgcagcagaa tgaatcttcc gaatggccaa caaaatgaaa ccataggaga 300 tcagaactgt caggatagtg acgatctcaa tggagcccac aaggtagaag agcaggagct 360 ggtttgtgtg agtgtcagaa caagaaatgg cgaggagagg agggatgtca caaaagacat 420 gtctaatttc attggatgcg cagaaggaca ggctgaatgt ggccacggtg tgtatggaag 480 catgcaaaat gccacccacg taggaagcaa cgatgagtgg cacatagact ctgggtgaca 540 tgctcactga gtacaggaga gggttgtaga tggcgacata gcggtcatat gccattgcag 600 ccaagagaaa gcattctgtg gtcccaaagg taacaaagag aagcatctgc gctgcacatc 660 caacatagga aatggcttta ttctctgcga ggaaattgac caacattttt ggggtgcaac 720 tgaagaataa caggcatcca ggaaagacaa tacgctcaga aagtagtaca tggggttgtg 780 tagccgagaa tccccaatga ctaatagaac tagccccaaa tttcctacca gagtaaaaag 840 gtagattgct agaaatagta aaaagaggaa gatttgcacc tcaaaatcat ctgtgaaacc 900 cgtcaatata aacatggtga ctttggtcac attttccat 939

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069269_0225_SL.TXT <210> 2990 <211> 131 <212> PRT <213> Felis catus

<400> 2990 Lys Val Thr Met Phe Ile Leu Thr Gly Phe Thr Met 1 Glu Asn Val Thr 5 10 15 Asp Asp Phe Glu Val Gln Ile Phe Leu Phe Leu Leu Phe Leu Ala Ile 20 25 30 Tyr Leu Phe Thr Leu Val Gly Asn Leu Gly Leu Val Leu Leu Val Ile 35 40 45 Gly Asp Ser Arg Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu 50 55 60 Ser Phe Leu Asp Ala Cys Tyr Ser Ser Val Ala Pro Gln Lys Cys Trp 65 70 75 80 Ser Ile Ser Ser Gln Arg Ile Lys Pro Phe Pro Met Leu Asp Val Gln 85 90 95 Arg Arg Cys Phe Ser Leu Leu Pro Leu Gly Pro Gln Asn Ala Phe Ser 100 105 110 Trp Leu Gln Trp His Met Thr Ala Met Ser Pro Ser Thr Thr Leu Ser 115 120 125

Cys Thr Gln 130 <210> 2991 <211> 928 <212> DNA <213> Felis catus <400> 2991 atgaagaatg tcactgaagt caccacattt gtactgaagg gcttcacaaa caaccttgaa

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ctacagatca tcttattctt cctgtttcta acaatctacc tctttactct gatgggcaac 120 ttaggactgg ttgtattggt ctttggggat tcccggctcc acaaccccat gtactatttt 180 ctaagtgtgt tatcatctgt ggatgcctgc tattcctcag taattacccc aaatatgtta 240 gtagatttca tgtcaaagaa taaagtcatt tcattccttg gatgtgcaac acagatgttt 300 ctggctgtta cctttgggac cacagaatgc tttctcttgg ctgcaatggc atatgaccgc 360 tatgtcgcca tctacaaccc cctcctgtac tcagtgagca tgtcacccag agtctatgta 420 ccactcatcg ctgcttcctt tgttggtggc attttgcatg cttgtgtaca caccatggcc 480 acattcagcc tgtccttctg cgcatccaac gaaattagac atgtcttttg tgacatccct 540 cctctcctcg ccatttcttg ttctgacact cacacaaacc agcttctact cttctacttt 600 gcagggtcta ttgagatatt tactctattg atagtcctga cctcctatgg ttttattatg 660 ttcataattc taaggatgca ttctgctgaa ggaagacgaa aaatcttttc tacatgtggt 720 tctcacctaa ctggagtgtc agtttttcac ggtacagttc tcttcatgta cgtgaaacct 780 aattccagct atgatttgga tcatgacatg atagtgtcag tattttacag cattgtgatt 840 cccatggtga atcccatgat ctatagctgg aggaacaaag atgtaaaaga cgcaatgcag 900 aaagtgttta agaaaaattg atttatca 928

<210> 2992 <211> 306 <212> PRT <213> Felis catus <400> 2992

Met 1 Lys Asn Val Thr 5 Glu Val Thr Thr Phe Val Leu 10 Lys Gly Phe 15 Thr Asn Asn Leu Glu Leu Gln Ile Ile Leu Phe Phe Leu Phe Leu Thr Ile 20 25 30 Tyr Leu Phe Thr Leu Met Gly Asn Leu Gly Leu Val Val Leu Val Phe 35 40 45 Gly Asp Ser Arg Leu His Asn Pro Met Tyr Tyr Phe Leu Ser Val Leu 50 55 60

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Ser 65 Ser Val Asp Ala Cys 70 Tyr Ser Ser Val Ile Thr 75 Pro Asn Met Leu 80 Val Asp Phe Met Ser Lys Asn Lys Val Ile Ser Phe Leu Gly Cys Ala 85 90 95 Thr Gln Met Phe Leu Ala Val Thr Phe Gly Thr Thr Glu Cys Phe Leu 100 105 110 Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Tyr Asn Pro Leu 115 120 125 Leu Tyr Ser Val Ser Met Ser Pro Arg Val Tyr Val Pro Leu Ile Ala 130 135 140 Ala Ser Phe Val Gly Gly Ile Leu His Ala Cys Val His Thr Met Ala 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys Ala Ser Asn Glu Ile Arg His Val Phe 165 170 175 Cys Asp Ile Pro Pro Leu Leu Ala Ile Ser Cys Ser Asp Thr His Thr 180 185 190 Asn Gln Leu Leu Leu Phe Tyr Phe Ala Gly Ser Ile Glu Ile Phe Thr 195 200 205 Leu Leu Ile Val Leu Thr Ser Tyr Gly Phe Ile Met Phe Ile Ile Leu 210 215 220 Arg Met His Ser Ala Glu Gly Arg Arg Lys Ile Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Gly Val Ser Val Phe His Gly Thr Val Leu Phe Met 245 250 255 Tyr Val Lys Pro Asn Ser Ser Tyr Asp Leu Asp His Asp Met Ile Val 260 265 270

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Ser Val Phe Tyr Ser Ile Val Ile Pro Met Val Asn Pro Met Ile Tyr 275 280 285 Ser Trp Arg Asn Lys Asp Val Lys Asp Ala Met Gln Lys Val Phe Lys 290 295 300

Lys Asn

305 <210> 2993 <211> 948 <212> DNA <213> Felis catus <400> 2993

atggcccaag ggaatctcac cccagtgact gagttcattc tcacaggagt ctcagacctc 60 ccagagctcc agattccact cttctttgtt ttcctggtga tctatgggtt cactgtggca 120 gggaacctgg gcatcatcac cctcaccagt gttgactctc aacttcaaac ccccatgtac 180 ttcttcctca ggcacttggc tatcatcaat cttggtgatt ctactgtcat tgccccaaaa 240 atgctggtta acttcttggc ttcaaaaaag accatatcct actatggatg tgcagcccaa 300 ctgggtgggt tcttagtctt tattgtggct gagattttca tgctagctgt aatggcctac 360 gaccgctacg tggctatttg caaccccctg ctctacgggg tggtggtatc tccacagatc 420 tgtctgctgc tggtatccct cacatacctc tacagtctga ccacagcact gaccgtcacc 480 tcctgtgtgt tctctgtatc atactgctct tccaatgtaa tcaatcattt ttactgtgat 540 aatgtccctt tgttggcatt gtcctgttct gatacttaca ttccagaaac agcagtgttt 600 accttttcag ggaccaattt gcttttctct atgattattg ttctaatttc ctatttcaac 660 atcgtccttg ccattttgag gatacgttcc tcagagggtc gacaaaaagc cttttccacc 720 tgtgcctccc acatgatggc tgtcactgtg ttctacggga cccttctctt catgtatttg 780 caaccaagga gcaaccactc attggatact gataaaatgg cctctgtctt ctacaccctg 840 gtgataccca tgctgaatcc cctcatttac agcctaagga acaaggatgt gaaggatgca 900 ttgaagagtt tcctaaataa ggcgtgtcag tctttcaaat tcatgtaa 948

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069269_0225_SL.TXT <210> 2994 <211> 315 <212> PRT <213> Felis catus

<400> 2994 Ile Leu Thr 15 Gly Met 1 Ala Gln Gly Asn Leu Thr Pro 5 Val Thr 10 Glu Phe Val Ser Asp Leu Pro Glu Leu Gln Ile Pro Leu Phe Phe Val Phe Leu 20 25 30 Val Ile Tyr Gly Phe Thr Val Ala Gly Asn Leu Gly Ile Ile Thr Leu 35 40 45 Thr Ser Val Asp Ser Gln Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 His Leu Ala Ile Ile Asn Leu Gly Asp Ser Thr Val Ile Ala Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Ala Ser Lys Lys Thr Ile Ser Tyr Tyr Gly 85 90 95 Cys Ala Ala Gln Leu Gly Gly Phe Leu Val Phe Ile Val Ala Glu Ile 100 105 110 Phe Met Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Gly Val Val Val Ser Pro Gln Ile Cys Leu Leu Leu 130 135 140 Val Ser Leu Thr Tyr Leu Tyr Ser Leu Thr Thr Ala Leu Thr Val Thr 145 150 155 160 Ser Cys Val Phe Ser Val Ser Tyr Cys Ser Ser Asn Val Ile Asn His 165 170 175 Phe Tyr Cys Asp Asn Val Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190

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Tyr Ile Pro 195 Glu Thr Ala Val Phe Thr Phe Ser Gly Thr Asn Leu Leu 200 205 Phe Ser Met Ile Ile Val Leu Ile Ser Tyr Phe Asn Ile Val Leu Ala 210 215 220 Ile Leu Arg Ile Arg Ser Ser Glu Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Met Met Ala Val Thr Val Phe Tyr Gly Thr Leu Leu 245 250 255 Phe Met Tyr Leu Gln Pro Arg Ser Asn His Ser Leu Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Leu Lys Ser Phe 290 295 300 Leu Asn Lys Ala Cys Gln Ser Phe Lys Phe Met 305 310 315

<210> 2995 <211> 971 <212> DNA <213> Felis catus <400> 2995

tcccacagca ttcttccttc atggccagga tgaaccaacc aaatcaaaca gtgctaacag 60 aattcatcct aatgggaatc acagaccggc cagggctgca ggctcccttc tttggactct 120 tcctcagcat ctatgtgatc tcagtggtgg gcaacctgag catgatcatc ctcaccaagg 180 tggactccag gctacaaaca cccatgtact tcttcctcag acacctggct ctcactgatc 240 tgggttattc aacaactata ggaccaaaaa tgttagtcaa tttcatagct aatcaaaaca 300 caatccccta taactggtgt gccacacagc tggctttctt catcttgttc atcatcagcg 360

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agcttttcat tctgtcagca atggcctatg accgctatgt ggccatctgt catcctctgc 420 tttatatggt tgttatgtca caaaaggtgt gctgggtgct ggtggccgtc ccctatgtct 480 acagtgcctt tctttctctg ataatcacca taaagatttt tatgtcatcc ttttgtgacc 540 ataatgtcat tagacatttt tattgtgaca atcttccctt attaactttg ttatgctcca 600 gcacacgtga cattgagttg ataatactga tcttttcagc atttaatttg gtgtcttctc 660 ttctgatagt gcttgtctcc tacatcttaa tcctgatggc catcctcagc atgaactctg 720 cacagggcag gcacaaggct ttctccacct gtggatccca tatgacagtg gtcgttgtat 780 tatatgcaac tctattcttc atgtacgtgc aacccaaatc cagtcattcc tttgatactg 840 ataaaattgc ctctgtattt tatactttga taatacctat gctgaatccc atgatctaca 900 gtttgaggaa caaagaggta aaaggtgccc tgcgtcggat atggaaaaat ctgcacaaac 960 tgcctatgta ^g 971

<210> 2996 <211> 316 <212> PRT <213> Felis catus <400> 2996

Met Ala Arg Met Asn Gln Pro Asn Gln Thr Val Leu Thr Glu Phe Ile 1 5 10 15 Leu Met Gly Ile Thr Asp Arg Pro Gly Leu Gln Ala Pro Phe Phe Gly 20 25 30 Leu Phe Leu Ser Ile Tyr Val Ile Ser Val Val Gly Asn Leu Ser Met 35 40 45 Ile Ile Leu Thr Lys Val Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe 50 55 60 Phe Leu Arg His Leu Ala Leu Thr Asp Leu Gly Tyr Ser Thr Thr Ile 65 70 75 80 Gly Pro Lys Met Leu Val Asn Phe Ile Ala Asn Gln Asn Thr Ile Pro 85 90 95

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Tyr Asn Trp Cys 100 Ala Thr Gln Leu Ala Phe Phe Ile Leu Phe Ile Ile 105 110 Ser Glu Leu Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Leu Tyr Met Val Val Met Ser Gln Lys Val Cys 130 135 140 Trp Val Leu Val Ala Val Pro Tyr Val Tyr Ser Ala Phe Leu Ser Leu 145 150 155 160 Ile Ile Thr Ile Lys Ile Phe Met Ser Ser Phe Cys Asp His Asn Val 165 170 175 Ile Arg His Phe Tyr Cys Asp Asn Leu Pro Leu Leu Thr Leu Leu Cys 180 185 190 Ser Ser Thr Arg Asp Ile Glu Leu Ile Ile Leu Ile Phe Ser Ala Phe 195 200 205 Asn Leu Val Ser Ser Leu Leu Ile Val Leu Val Ser Tyr Ile Leu Ile 210 215 220 Leu Met Ala Ile Leu Ser Met Asn Ser Ala Gln Gly Arg His Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Met Thr Val Val Val Val Leu Tyr Ala 245 250 255 Thr Leu Phe Phe Met Tyr Val Gln Pro Lys Ser Ser His Ser Phe Asp 260 265 270 Thr Asp Lys Ile Ala Ser Val Phe Tyr Thr Leu Ile Ile Pro Met Leu 275 280 285 Asn Pro Met Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Leu 290 295 300

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Arg Arg Ile Trp Lys Asn Leu His Lys Leu Pro Met 305 310 315 <210> 2997 <211> 896 <212> DNA <213> Felis catus <400> 2997 acaaacacaa tctaacactg ttgaaagaat tcattctaat gggaatcaca ggactccctg 60 agctgcaggc tccattattt ggactactcc tcactgtata tctggtctca gtcgtgggta 120 atctgggttt gatcatcctc accaagatag actctaggct acaaacaccc atgtacttct 180 tcctcagaca cctggctttc actgatcttg gttattcaac agctgtggga cccaaaatgc 240 tagtaaatta tgctgtagat caacatacaa tctcctttaa tgggtgtgcc acccaactca 300 cttttttcaa tatttttatc attaatgaaa ttttcattct gtcggcaatg gcctatgacc 360 actatgtggc cgtctgtaac cctctgctct acacagctgt tatgtcacaa agattatgtc 420 aggtgctagt ggtaatgcct tgtctctata gtgtctcttt gtctttgttg accatcatga 480 aaattttcct ttcatcattt agtgaatata atgtcatcag gcatttctac tgtgacagtc 540 taccattgat agctttgctc tgttcaggca ccgatgaaat tagattgata attctgatct 600 tttctgcttt taatttggtg tcatctcttc tcacagtcct tgtgtcctac attctaatct 660 ctgttgccat cttcaggatg aactctgcag aaggcaggca caaggctttc tccacctgtg 720 gatcccatct ggcagtgatt gccttattct atggcactct attctttatg tatgtgcagc 780 cgaaatctac tcattccttt gatactgata atatggccgc cttattttac atgttggtta 840 tacccatgct gaatccaatg atctacagct tgaggaacaa agaggtgaaa aatgcc 896 <210> 2998 <211> 298 <212> PRT <213> Felis catus <400> 2998

Lys His Asn Leu Thr Leu Leu Lys Glu Phe Ile Leu Met Gly Ile Thr 1 5 10 15

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Gly Leu Pro Glu 20 Leu Gln Ala 069269_0225_SL.TXT Pro Leu Phe Gly Leu Leu 25 Leu 30 Thr Val Tyr Leu Val Ser Val Val Gly Asn Leu Gly Leu Ile Ile Leu Thr Lys 35 40 45 Ile Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg His Leu 50 55 60 Ala Phe Thr Asp Leu Gly Tyr Ser Thr Ala Val Gly Pro Lys Met Leu 65 70 75 80 Val Asn Tyr Ala Val Asp Gln His Thr Ile Ser Phe Asn Gly Cys Ala 85 90 95 Thr Gln Leu Thr Phe Phe Asn Ile Phe Ile Ile Asn Glu Ile Phe Ile 100 105 110 Leu Ser Ala Met Ala Tyr Asp His Tyr Val Ala Val Cys Asn Pro Leu 115 120 125 Leu Tyr Thr Ala Val Met Ser Gln Arg Leu Cys Gln Val Leu Val Val 130 135 140 Met Pro Cys Leu Tyr Ser Val Ser Leu Ser Leu Leu Thr Ile Met Lys 145 150 155 160 Ile Phe Leu Ser Ser Phe Ser Glu Tyr Asn Val Ile Arg His Phe Tyr 165 170 175 Cys Asp Ser Leu Pro Leu Ile Ala Leu Leu Cys Ser Gly Thr Asp Glu 180 185 190 Ile Arg Leu Ile Ile Leu Ile Phe Ser Ala Phe Asn Leu Val Ser Ser 195 200 205 Leu Leu Thr Val Leu Val Ser Tyr Ile Leu Ile Ser Val Ala Ile Phe 210 215 220

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Arg 225 Met Asn Ser Ala Glu 230 Gly 069269_0225_SL.TXT Thr Cys Gly 240 Arg His Lys Ala Phe Ser 235 Ser His Leu Ala Val Ile Ala Leu Phe Tyr Gly Thr Leu Phe Phe Met 245 250 255 Tyr Val Gln Pro Lys Ser Thr His Ser Phe Asp Thr Asp Asn Met Ala 260 265 270 Ala Leu Phe Tyr Met Leu Val Ile Pro Met Leu Asn Pro Met Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Asn Ala 290 295

<210> 2999 <211> 942 <212> DNA <213> Felis catus <400> 2999

atggaaaaac acaatctgac agtgtttaat gaatttattc tcatgggaat cacacaacgt 60 cctgagctgc aggctccatt atttgggctc ttcctcatca tctatgtgat ctcagtggtg 120 ggcaacctgg gcctgatcat cctcgccaag gtggactcca ggctacaaac acccatgtac 180 ttcttcctca aacacctggc tctcactgat ctgggttatt caacaactgt gggacccaaa 240 atgttagcaa gttttgttgt ggaagaaaac acaatttcct atcatttgtg tgccacacag 300 ggagcattct acattatgtt catcgttagc gagcttttca ttctgtcggc tatgtcctat 360 gaccgctatg tggccatctg taatcctctg ctctatccag tcatcatgtc acaaagggtg 420 tgtcaggtgc tgatgacaat cctctatctc tacagcacat ttatggctct actagtcacc 480 ataaggattt ttagttcatc cttctgtggt tacaatgtca tcagccattt ctactgtgac 540 tgtcttccct tgctatcctt gctctgctca aacatgcatg aaattgaatt gatgattttg 600 gctttctcag tttttaattt gatgtcctcc cttctgatgg ttgttgtgtc ttacctgctg 660 atcctactag ccatagtcag gatgaactca gctgagggta ggcacaaagc cttttctaca 720 tgtgggtccc acctgacagt ggccacagtg ttttatggga ctatgatatt tatgtatgca 780

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069269_0225_SL.TXT caacctgagt ccagtcattc ctttgacact gataaaatgg cgtccatatt ttacaccctt gttatcccca tgttgaatcc catgatctat agtctgagga acaaagatgt aaaatgtgct ttccatagga tatggaaaaa gttatgaggt accttttctt aa

840

900

942 <210> 3000 <211> 308 <212> PRT <213> Felis catus

<400> 3000 Leu Thr Val Phe Asn Glu Phe Ile Leu Met Gly Met Glu 1 Lys His Asn 5 10 15 Ile Thr Gln Arg Pro Glu Leu Gln Ala Pro Leu Phe Gly Leu Phe Leu 20 25 30 Ile Ile Tyr Val Ile Ser Val Val Gly Asn Leu Gly Leu Ile Ile Leu 35 40 45 Ala Lys Val Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Lys 50 55 60 His Leu Ala Leu Thr Asp Leu Gly Tyr Ser Thr Thr Val Gly Pro Lys 65 70 75 80 Met Leu Ala Ser Phe Val Val Glu Glu Asn Thr Ile Ser Tyr His Leu 85 90 95 Cys Ala Thr Gln Gly Ala Phe Tyr Ile Met Phe Ile Val Ser Glu Leu 100 105 110 Phe Ile Leu Ser Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Pro Val Ile Met Ser Gln Arg Val Cys Gln Val Leu 130 135 140 Met Thr Ile Leu Tyr Leu Tyr Ser Thr Phe Met Ala Leu Leu Val Thr 145 150 155 160

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Ile Arg Ile Phe Ser Ser Ser Phe Cys Gly Tyr Asn Val Ile Ser His 165 170 175 Phe Tyr Cys Asp Cys Leu Pro Leu Leu Ser Leu Leu Cys Ser Asn Met 180 185 190 His Glu Ile Glu Leu Met Ile Leu Ala Phe Ser Val Phe Asn Leu Met 195 200 205 Ser Ser Leu Leu Met Val Val Val Ser Tyr Leu Leu Ile Leu Leu Ala 210 215 220 Ile Val Arg Met Asn Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Ala Thr Val Phe Tyr Gly Thr Met Ile 245 250 255 Phe Met Tyr Ala Gln Pro Glu Ser Ser His Ser Phe Asp Thr Asp Lys 260 265 270 Met Ala Ser Ile Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Cys Ala Phe His Arg Ile 290 295 300

Trp Lys Lys Leu 305 <210> 3001 <211> 942 <212> DNA <213> Felis catus <400> 3001 atggaaaaag ataatctaac agggctgaat gaattcattc tcatgggaat cacagaccgt cctgagctgc aggctccatt atttgggctc ttcctcatca tctatgtgat ctcagtggtg ggcaacctgg gcatgatcat cctcaccaag atggactcca ggctacaaac acccatgtac

120

180

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069269_0225_SL.TXT ttcttcctca aacacctggc tctcactgat ctgggttatt caacaactgt aggacccaaa atgctagtca attttgttgt ggatcaaaat acaatcccct attatttttg tgctatacag ctcgctttct ttcttgtgtt catcattagt gaacttttca ttctgtcagc gatgtcttat gatcgctatg tggccatctg taaccctctg ctctacccaa tcgtcatgtc acaaagtgtg tgtcaggtgc tagtggcaat cccctatctc tacagtgcat ttgtgtctct tctagtcacc atgaagattt ttagttcatc cttctgtggc tacaatgtca ttagtcattt ctactgtgac agtctcccct tgatatcttt gctttgctca aatacacatg aaattgaact gattattctg atcttagcag gctttaattt gattttttcc cttttgatag ttattgtgtc ttacctcctg atccttgtag ccatcgtcag gatgaactca gctgagggta ggcacaaggc cttctccacc tgcgggtccc acctgacagt ggccacagtg ttctatggga ctctgatatt tatgtatgtg caacctgagt ccagtcattc ctttgacact gataaagtgg cgtccatatt ttacaccctt gttatcccca tgttgaatcc cttgatctat ggcttgagga acaaggatgt aaaatgtgct gtacaaacaa tgtggaaaaa gctatgtaat cttttttctt aa <210> 3002 <211> 313 <212> PRT <213> Felis catus

240

300

360

420

480

540

600

660

720

780

840

900

942

<400> 3002 Met Glu Lys Asp 1 Asn 5 Leu Thr Gly Leu Asn Glu Phe Ile Leu Met Gly 10 15 Ile Thr Asp Arg Pro Glu Leu Gln Ala Pro Leu Phe Gly Leu Phe Leu 20 25 30 Ile Ile Tyr Val Ile Ser Val Val Gly Asn Leu Gly Met Ile Ile Leu 35 40 45 Thr Lys Met Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Lys 50 55 60 His Leu Ala Leu Thr Asp Leu Gly Tyr Ser Thr Thr Val Gly Pro Lys 65 70 75 80

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Met Leu Val Asn Phe Val Val Asp Gln Asn Thr Ile Pro Tyr Tyr Phe 85 90 95 Cys Ala Ile Gln Leu Ala Phe Phe Leu Val Phe Ile Ile Ser Glu Leu 100 105 110 Phe Ile Leu Ser Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Pro Ile Val Met Ser Gln Ser Val Cys Gln Val Leu 130 135 140 Val Ala Ile Pro Tyr Leu Tyr Ser Ala Phe Val Ser Leu Leu Val Thr 145 150 155 160 Met Lys Ile Phe Ser Ser Ser Phe Cys Gly Tyr Asn Val Ile Ser His 165 170 175 Phe Tyr Cys Asp Ser Leu Pro Leu Ile Ser Leu Leu Cys Ser Asn Thr 180 185 190 His Glu Ile Glu Leu Ile Ile Leu Ile Leu Ala Gly Phe Asn Leu Ile 195 200 205 Phe Ser Leu Leu Ile Val Ile Val Ser Tyr Leu Leu Ile Leu Val Ala 210 215 220 Ile Val Arg Met Asn Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Ala Thr Val Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Met Tyr Val Gln Pro Glu Ser Ser His Ser Phe Asp Thr Asp Lys 260 265 270 Val Ala Ser Ile Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285

Page 3347

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Ile Tyr Gly Leu Arg Asn Lys Asp Val Lys Cys Ala Val Gln Thr Met 290 295 300

Trp Lys Lys Leu Cys Asn Leu Phe Ser

305 310 <210> 3003 <211> 943 <212> DNA <213> Felis catus <400> 3003

atggaaacac ataatctaac aatgctcaat gaattcattc tcatgggaat cacagaccgt 60 cctgagctgc aggctccatt atttgggctc ttcctcatca tctatatgat ctcagtggtg 120 ggcaacctgg gcatgatcat cctcacccag atggactcca ggctgcaaac acccatgtac 180 ttcttcctca gacacctggc tctcaccgat ctgggttatt caacaactgt aggacccaaa 240 atgctagtca attttgttgt ggatcaaaat acaatctcct gttatttttg tgctatacag 300 ctcgctttct ttcttgtgtt cattgttagt gaacttttta ttctaacagc aatgtcctac 360 gaccgctatg tggccatctg tcaccctctg cgctatccag tcatcatgtc acaaagggtg 420 tgtcaggtgc tggtggccat cctctatctc tacagcacat ttgtgtctct tatagtcacc 480 atcaagattt ttagttcgtc cttctgtggc tacaatgtca ttagtcattt ctactgtgac 540 agtctcccct tgatatcttt gctttgctca aatacacatg aaactgaaat gattattctg 600 attttagccg gttttgattt gatttcatcc cttttgatag ttattgtgtc ttacctcctg 660 atccttgtag ccatcgtcag gatgaactca gctgagggta gacacaaggc tttttctacc 720 tgtgggtccc acctgacagt ggccacagtg ttttatggga ctctgatatt tatgtatgtg 780 caacctgagt ccagtcattc ctttgacact gataaagtgg catccatatt ttacaccctt 840 gttatcccca tgttgaatcc cttgatctat agcttgagga acaaggatat aaaatatgca 900 ggacaaagga tgtggaaaaa aatatgtaat tcttttttct taa 943

<210> 3004 <211> 315 <212> PRT

Page 3348

069269_0225_SL.TXT <213> Felis catus <220>

<221> MOD_RES <222> (315)..(315) <223> Any amino acid

<400> 3004 Met Glu Thr His Asn Leu Thr Met Leu Asn Glu Phe Ile Leu Met Gly 1 5 10 15 Ile Thr Asp Arg Pro Glu Leu Gln Ala Pro Leu Phe Gly Leu Phe Leu 20 25 30 Ile Ile Tyr Met Ile Ser Val Val Gly Asn Leu Gly Met Ile Ile Leu 35 40 45 Thr Gln Met Asp Ser Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 His Leu Ala Leu Thr Asp Leu Gly Tyr Ser Thr Thr Val Gly Pro Lys 65 70 75 80 Met Leu Val Asn Phe Val Val Asp Gln Asn Thr Ile Ser Cys Tyr Phe 85 90 95 Cys Ala Ile Gln Leu Ala Phe Phe Leu Val Phe Ile Val Ser Glu Leu 100 105 110 Phe Ile Leu Thr Ala Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Pro Val Ile Met Ser Gln Arg Val Cys Gln Val Leu 130 135 140 Val Ala Ile Leu Tyr Leu Tyr Ser Thr Phe Val Ser Leu Ile Val Thr 145 150 155 160 Ile Lys Ile Phe Ser Ser Ser Phe Cys Gly Tyr Asn Val Ile Ser His 165 170 175

Page 3349

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Phe Tyr Cys Asp Ser Leu Pro Leu Ile Ser Leu Leu Cys Ser Asn Thr 180 185 190 His Glu Thr Glu Met Ile Ile Leu Ile Leu Ala Gly Phe Asp Leu Ile 195 200 205 Ser Ser Leu Leu Ile Val Ile Val Ser Tyr Leu Leu Ile Leu Val Ala 210 215 220 Ile Val Arg Met Asn Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Ala Thr Val Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Met Tyr Val Gln Pro Glu Ser Ser His Ser Phe Asp Thr Asp Lys 260 265 270 Val Ala Ser Ile Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Tyr Ala Gly Gln Arg Met 290 295 300 Trp Lys Lys Ile Cys Asn Ser Phe Phe Leu Xaa

305 310 315 <210> 3005 <211> 944 <212> DNA <213> Felis catus <400> 3005 ttaacagggg aaatgtttca tctctatggc ccttttcaca gcatccttta cctctttgtt cctcagactg taaataagtg ggtttaacat gggaatcact agtgtataga acacagaaac caccttctcc tgctccacag aatactggga acttggctga atgtaactaa agcttaaggt accatagaat atggtcacag aagtcaggtg agaggcacag gtggagaagg ctttctgtct acctgctgct gaactgatcc tcaggatagt gataaaaatg aaaatgtagg aaatgaccac

120

180

240

300

Page 3350

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aatcaaaaaa gtagccatgg caatgactcc agaaaaagtt aagagcagca actcattctt 360 ggatgtatca gaacacgaca gctttagcag tgggggaaca tcacagaaga agtggctaac 420 aacattggac ccacaaaagg acagtcttcc caagcttatt gtgtgtatca atgagttgag 480 cattccaccg acaaatgacc cagtgaccag ccctacacac ttccttttag acatgactac 540 actgtaaagc aaagggttgg caatggccac atagcggtca taggccatca atgacagcaa 600 gaagccttct gtggtgataa acaccccaaa aaacaaatgc tgcactatgc aggcagataa 660 tgagatggtt tccctcacaa ccaagaagtt gatcagcatt ttcggtgcaa taacagatga 720 atagcaggca tctataaatg aaaggcagct taggaaaaag tacatgggtg tgtggagctt 780 gggagtgatt tggattaaga aaatcatgcc cagattccct gccaaggtaa ttgcataaat 840 caccaagaac aacacaaaaa gcatgatttt caggtcagca ttatctgtca atcccaaaag 900 aataaattca gtaacagctg tgaaattttc ttcggccatt tgtt 944

<210> 3006 <211> 312 <212> PRT <213> Felis catus

<400> 3006 Met Ala Glu Glu 1 Asn 5 Phe Thr Ala Val Thr Glu Phe Ile Leu Leu Gly 10 15 Leu Thr Asp Asn Ala Asp Leu Lys Ile Met Leu Phe Val Leu Phe Leu 20 25 30 Val Ile Tyr Ala Ile Thr Leu Ala Gly Asn Leu Gly Met Ile Phe Leu 35 40 45 Ile Gln Ile Thr Pro Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Cys Leu Ser Phe Ile Asp Ala Cys Tyr Ser Ser Val Ile Ala Pro Lys 65 70 75 80

Met Leu Ile Asn Phe Leu Val Val Arg Glu Thr Ile 85 90

Ser Leu Ser Ala 95

Page 3351

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Cys Ile Val Gln His Leu Phe Phe Gly Val Phe Ile Thr Thr Glu Gly 100 105 110 Phe Leu Leu Ser Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Ala Asn 115 120 125 Pro Leu Leu Tyr Ser Val Val Met Ser Lys Arg Lys Cys Val Gly Leu 130 135 140 Val Thr Gly Ser Phe Val Gly Gly Met Leu Asn Ser Leu Ile His Thr 145 150 155 160 Ile Ser Leu Gly Arg Leu Ser Phe Cys Gly Ser Asn Val Val Ser His 165 170 175 Phe Phe Cys Asp Val Pro Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190 Ser Lys Asn Glu Leu Leu Leu Leu Thr Phe Ser Gly Val Ile Ala Met 195 200 205 Ala Thr Phe Leu Ile Val Val Ile Ser Tyr Ile Phe Ile Phe Ile Thr 210 215 220 Ile Leu Arg Ile Ser Ser Ala Ala Gly Arg Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ser Val Thr Ile Phe Tyr Gly Thr Leu Ser 245 250 255 Phe Ser Tyr Ile Gln Pro Ser Ser Gln Tyr Ser Val Glu Gln Glu Lys 260 265 270 Val Val Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Val Lys Arg Ala 290 295 300

Page 3352

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Ile Glu Met Lys His Phe Pro Cys 305 310 <210> 3007 <211> 915 <212> DNA <213> Felis catus <400> 3007

atgggccaac agaatctaac atcactgacg gagttcattc tgatgggagt cacaaggcag 60 cctgagctac aggttcccct ttttggggtc ttcctcatca tctatacagt cacagtggtg 120 ggcaacctgg gcatgatcat cttgacccag gtggactccc gcctacatac acctatgtat 180 ttttttatca aacatctggc tttcattgat cttggtaatt ctactgtcat ttgtcccaag 240 atgctggtaa attttgttgt ggatcaaaat gccatttctt attatgcatg tgccacacag 300 ttggctttct tccttatgtt catcattagt gaatttttca tcttgtcggc catggcctat 360 gaccgctatt tggccatctg taaccctctg ctctacaatg ttactatgtc ccagagactt 420 tgtcacatgc tagtgggcat tccatacctc tacagtacct ttcaggctct aatgttcact 480 attaagattt ttacattgac cttctgtggt tctaatgtca tcagtcattt ctattgtgat 540 gatgttgcct tgttacttat gctctgctca aatgcacaag acatagaatt gttgatcata 600 ctattttcag cacttaattt gatctcttcc ctgatggtag tccttgtgtc ttatatacta 660 attctgatat ccatatttca aatgcattct gcagagggta ggaaaaaagc tttctccacg 720 tgtgggtctc atttgacagt ggtgattgtg ttctatgggt ctctactatt tatgtacatg 780 cagcccaaat ctgcccactc ttttgatact gataaaatgg cttctgtgtt ttacacatta 840 gtgatcccca tgcttaaccc cttgatctac agcttaagaa acaaagaggt aaaaaatgcc 900 ttccgcaggg tcttt 915

<210> 3008 <211> 305 <212> PRT <213> Felis catus <400> 3008

Met Gly Gln Gln Asn Leu Thr Ser Leu Thr Glu Phe Ile Leu Met Gly Page 3353

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1 5 10 15 Val Thr Arg Gln Pro Glu Leu Gln Val Pro Leu Phe Gly Val Phe Leu 20 25 30 Ile Ile Tyr Thr Val Thr Val Val Gly Asn Leu Gly Met Ile Ile Leu 35 40 45 Thr Gln Val Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Ile Lys 50 55 60 His Leu Ala Phe Ile Asp Leu Gly Asn Ser Thr Val Ile Cys Pro Lys 65 70 75 80 Met Leu Val Asn Phe Val Val Asp Gln Asn Ala Ile Ser Tyr Tyr Ala 85 90 95 Cys Ala Thr Gln Leu Ala Phe Phe Leu Met Phe Ile Ile Ser Glu Phe 100 105 110 Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Thr Met Ser Gln Arg Leu Cys His Met Leu 130 135 140 Val Gly Ile Pro Tyr Leu Tyr Ser Thr Phe Gln Ala Leu Met Phe Thr 145 150 155 160 Ile Lys Ile Phe Thr Leu Thr Phe Cys Gly Ser Asn Val Ile Ser His 165 170 175 Phe Tyr Cys Asp Asp Val Ala Leu Leu Leu Met Leu Cys Ser Asn Ala 180 185 190 Gln Asp Ile Glu Leu Leu Ile Ile Leu Phe Ser Ala Leu Asn Leu Ile 195 200 205 Ser Ser Leu Met Val Val Leu Val Ser Tyr Ile Leu Ile Leu Ile Ser

Page 3354

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210 215 220

Ile 225 Phe Gln Met His Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 240 230 235 Cys Gly Ser His Leu Thr Val Val Ile Val Phe Tyr Gly Ser Leu Leu 245 250 255 Phe Met Tyr Met Gln Pro Lys Ser Ala His Ser Phe Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Phe Arg Arg Val

290 295 300

Phe

305 <210> 3009 <211> 959 <212> DNA <213> Felis catus <400> 3009

atgaatccta tggagaaaca gaatcattct gcagtgattg aggtgactga atttattctc 60 ctggggatca ccagcaatcc tgggctacaa gcacctctcc tcgcaatctt cctcatcata 120 tatttgatca cagtgacagg caatctgggc atagttatct tgacccattt ggactccaag 180 ctaaataccc ccatgtactt tttccttaga catctgtcaa ttactgatct tggttactcc 240 actgtcatcg gcccaaaaat gatggtaaac tttgtggtgc acaaaaatac aatttcctac 300 cattggtgtg ccacccagct ggcagtcttt gagattttca tcatcaccga actgttcatt 360 ctttcagcaa tggcctatga tcgctacgta gccatctgca aacctctcct ctacgtggtc 420 atcatggcag agaaggtgcg ttgggcgctg gtccttattc cttatttcta cagcacattt 480 gtgtcgctct ttctcacaat caaattattt aaattgtcct tctgtggctc taacattatc 540 aggtattttt actgtgactg ccttcctctc atatccatgc tctgttcaga cacacatgaa 600

Page 3355

069269_0225_SL.TXT ttagaattga tcattttaag tttttcaggc tgtaatctgc tctcttccct cttgattgtt cttatatcct acatgtttat tcttgtggcc atcctcagaa tgaactcaac cgaggggaga tacaaagcct tctcaacctg tagttcccac ttgacggtgg tggtcgtgtt ctatgggaca ttattgttta tttacctgca gcccaaatcc agccatactt ttgatattga taagatggcc tctgtgtttt acactttggt gatccctatg ctgaatccat ggatctacag cttaaggaac aaagaagtaa aagatgctct gaagagaatt ttaaccaacc gatgcaaaat tcccactta

660

720

780

840

900

959 <210> 3010 <211> 320 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (320)..(320) <223> Any amino acid

<400> 3010 Lys Gln Asn His Ser Ala Val Ile Glu Val Thr Met Asn 1 Pro Met Glu 5 10 15 Glu Phe Ile Leu Leu Gly Ile Thr Ser Asn Pro Gly Leu Gln Ala Pro 20 25 30 Leu Leu Ala Ile Phe Leu Ile Ile Tyr Leu Ile Thr Val Thr Gly Asn 35 40 45 Leu Gly Ile Val Ile Leu Thr His Leu Asp Ser Lys Leu Asn Thr Pro 50 55 60 Met Tyr Phe Phe Leu Arg His Leu Ser Ile Thr Asp Leu Gly Tyr Ser 65 70 75 80 Thr Val Ile Gly Pro Lys Met Met Val Asn Phe Val Val His Lys Asn 85 90 95 Thr Ile Ser Tyr His Trp Cys Ala Thr Gln Leu Ala Val Phe Glu Ile 100 105 110

Page 3356

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Phe Ile Ile 115 Thr Glu Leu Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg 120 125 Tyr Val Ala Ile Cys Lys Pro Leu Leu Tyr Val Val Ile Met Ala Glu 130 135 140 Lys Val Arg Trp Ala Leu Val Leu Ile Pro Tyr Phe Tyr Ser Thr Phe 145 150 155 160 Val Ser Leu Phe Leu Thr Ile Lys Leu Phe Lys Leu Ser Phe Cys Gly 165 170 175 Ser Asn Ile Ile Arg Tyr Phe Tyr Cys Asp Cys Leu Pro Leu Ile Ser 180 185 190 Met Leu Cys Ser Asp Thr His Glu Leu Glu Leu Ile Ile Leu Ser Phe 195 200 205 Ser Gly Cys Asn Leu Leu Ser Ser Leu Leu Ile Val Leu Ile Ser Tyr 210 215 220 Met Phe Ile Leu Val Ala Ile Leu Arg Met Asn Ser Thr Glu Gly Arg 225 230 235 240 Tyr Lys Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Val Val 245 250 255 Phe Tyr Gly Thr Leu Leu Phe Ile Tyr Leu Gln Pro Lys Ser Ser His 260 265 270 Thr Phe Asp Ile Asp Lys Met Ala Ser Val Phe Tyr Thr Leu Val Ile 275 280 285 Pro Met Leu Asn Pro Trp Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys 290 295 300 Asp Ala Leu Lys Arg Ile Leu Thr Asn Arg Cys Lys Ile Pro Thr Xaa 305 310 315 320

Page 3357

069269_0225_SL.TXT <210> 3011 <211> 928 <212> DNA <213> Felis catus <400> 3011

atggctccag ggaacctcac cctggtgact gagttcattc tcatgggagt ctcagaccgc 60 ccagagctcc agattccact cttctttgtt ttcctggtga tctatgggct gaccatggca 120 gggaatctgg gcatcatcac cctcaccagt gttgactctc aacttcaaac ccccatgtac 180 ttcttcctgc gccatttggc tatcatcaat cttggcgatt ctactgtcat tgcccctaaa 240 atgctgatca attttttagt acagaagaaa accacctcat actatgaatg tgccacccaa 300 ctgggagggt tcttattttt cattgtagcc gaggtgctca cgttagctgt gatggcttat 360 gaccgctatg tggccatttg taaccccctg ctttacatgg tggtggtatc tccacagatc 420 tgccttcttc tggtatccct cacatatctc tatggctttt ccacaggtat tgtggtttca 480 tattgtatat tttctctgtc ttattgctct tccaatgtaa tcaatcattt cttctgtgat 540 attgtcccac tgttaacatt gtcctgctct gatacttacc ttccagagac aatagtattt 600 atatccgcag ctacaaattt ggtcttatcg ttgataatag ttgtagtatc ttatttcaac 660 attgttttgt ccattctaag gatgcgttca tcagaaggaa ggaaaaaagc cttttccaca 720 tgtgcttcac atatgatggc tgtcactgtg ttctatggga cccttctctt catgtatttg 780 cagcctcaaa ctaactactc attggatacc gataaaattg cttctgtgtt ttatacactg 840 gtgatcccca tgttgaatcc catgatctac agcctgcgga ataaggatgt gaaggctgcc 900 ttacagagat ttctaacaat ttcatgct 928

<210> 3012 <211> 310 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (310)..(310) <223> Any amino acid

Page 3358

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<400> 3012 Asn Leu Thr Leu Val Thr Glu Phe Ile Leu Met Gly 15 Met 1 Ala Pro Gly 5 10 Val Ser Asp Arg Pro Glu Leu Gln Ile Pro Leu Phe Phe Val Phe Leu 20 25 30 Val Ile Tyr Gly Leu Thr Met Ala Gly Asn Leu Gly Ile Ile Thr Leu 35 40 45 Thr Ser Val Asp Ser Gln Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 His Leu Ala Ile Ile Asn Leu Gly Asp Ser Thr Val Ile Ala Pro Lys 65 70 75 80 Met Leu Ile Asn Phe Leu Val Gln Lys Lys Thr Thr Ser Tyr Tyr Glu 85 90 95 Cys Ala Thr Gln Leu Gly Gly Phe Leu Phe Phe Ile Val Ala Glu Val 100 105 110 Leu Thr Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Val Val Val Ser Pro Gln Ile Cys Leu Leu Leu 130 135 140 Val Ser Leu Thr Tyr Leu Tyr Gly Phe Ser Thr Gly Ile Val Val Ser 145 150 155 160 Tyr Cys Ile Phe Ser Leu Ser Tyr Cys Ser Ser Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Val Pro Leu Leu Thr Leu Ser Cys Ser Asp Thr 180 185 190 Tyr Leu Pro Glu Thr Ile Val Phe Ile Ser Ala Ala Thr Asn Leu Val 195 200 205

Page 3359

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Leu Ser Leu Ile Ile Val Val Val Ser Tyr Phe Asn Ile Val Leu Ser 210 215 220 Ile Leu Arg Met Arg Ser Ser Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Met Met Ala Val Thr Val Phe Tyr Gly Thr Leu Leu 245 250 255 Phe Met Tyr Leu Gln Pro Gln Thr Asn Tyr Ser Leu Asp Thr Asp Lys 260 265 270 Ile Ala Ser Val Phe Tyr Thr Leu Val Ile Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala Leu Gln Arg Phe 290 295 300 Leu Thr Ile Ser Cys Xaa

305 310

<210> 3013 <211> 952 <212> DNA <213> Felis catus <400> 3013 cagataaatt gcacccacgt aaaggatttt attctcacgg gcctcacaga tcgaaaggaa 60 ttaaagacgc ccttctttgt ggttttctta tctatctacc tcttcacagt agttggtaac 120 ctcggcttga tcctagtcat tagaacagac tcaagactca acacaccgat gtacttcttt 180 cttagcaacc tggcgtttgt tgacttttgc tactcttctg tcattacacc caaaatgctt 240 gggaatttct tgtacaaaca aaatgttatc tctttcaatg catgtgctgc tcaattaggc 300 tgtttcctgg ccttcatgac cgctgaatgc ttgctactgg cttccatggc ctatgacaga 360 tacgtggcca tttgtaaccc tctcctctac ctggttgtca tgtccccagg aatctgcatt 420 cagcttgtgg ttgtccccta cagctatagc ttcctggttg cactatttca tactatcctc 480 acctttcgcc tctcctattg ccactccaac gtcatcaatc atttctattg tgatgacatg 540

Page 3360

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cctctcctca ggctaacctg ctcagacact cactccaaac agctatggat ctttgtctgt 600 gctgggatca tgttcatttc ttcccttctg gtcgtctttg tctcctacac gtacattatt 660 tctgccatcc tgaggatgcg ctcagctgag ggcaggcgca aggctttctc cacgtgtggc 720 tctcacatgc tggcggtcac catattctat gggaccctta tctttatgta cttacagcca 780 agctcaaacc attccctaga cacggataag atggcctcag tcttctatac agtgatcatt 840 cctatgttga accctttgat ctacagcctt aggaacaagg aggtgaaaga tgctctgaag 900 aaagtcattg tcaatagaaa ccaggctttt gtgttcatta aattaaggaa gt 952

<210> 3014 <211> 318 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (318)..(318) <223> Any amino acid <400> 3014

Gln Ile Asn Cys Thr His Val Lys Asp Phe Ile Leu Thr Gly Leu Thr 1 5 10 15 Asp Arg Lys Glu Leu Lys Thr Pro Phe Phe Val Val Phe Leu Ser Ile 20 25 30 Tyr Leu Phe Thr Val Val Gly Asn Leu Gly Leu Ile Leu Val Ile Arg 35 40 45 Thr Asp Ser Arg Leu Asn Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ala Phe Val Asp Phe Cys Tyr Ser Ser Val Ile Thr Pro Lys Met Leu 65 70 75 80 Gly Asn Phe Leu Tyr Lys Gln Asn Val Ile Ser Phe Asn Ala Cys Ala 85 90 95

Page 3361

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Ala Gln Leu Gly 100 Cys Phe Leu Ala Phe Met Thr Ala Glu Cys Leu Leu 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 115 120 125 Leu Tyr Leu Val Val Met Ser Pro Gly Ile Cys Ile Gln Leu Val Val 130 135 140 Val Pro Tyr Ser Tyr Ser Phe Leu Val Ala Leu Phe His Thr Ile Leu 145 150 155 160 Thr Phe Arg Leu Ser Tyr Cys His Ser Asn Val Ile Asn His Phe Tyr 165 170 175 Cys Asp Asp Met Pro Leu Leu Arg Leu Thr Cys Ser Asp Thr His Ser 180 185 190 Lys Gln Leu Trp Ile Phe Val Cys Ala Gly Ile Met Phe Ile Ser Ser 195 200 205 Leu Leu Val Val Phe Val Ser Tyr Thr Tyr Ile Ile Ser Ala Ile Leu 210 215 220 Arg Met Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Gly 225 230 235 240 Ser His Met Leu Ala Val Thr Ile Phe Tyr Gly Thr Leu Ile Phe Met 245 250 255 Tyr Leu Gln Pro Ser Ser Asn His Ser Leu Asp Thr Asp Lys Met Ala 260 265 270 Ser Val Phe Tyr Thr Val Ile Ile Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Lys Lys Val Ile Val 290 295 300

Page 3362

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Asn Arg Asn Gln Ala Phe Val Phe Ile Lys Leu Arg Lys Xaa 305 310 315 <210> 3015 <211> 817 <212> DNA <213> Felis catus <400> 3015

tgatctactt aattagtgtc ataggtaatc ttgggttaat tatgctaatt tatacccgtt 60 ctcagcttca cacacccatg tattcttttg tcagcaatct agcttttgtt gctttttgct 120 acacctcctc tgtcacccct aacaccctgg tgaacttcct ccaagaaatt aagagaatat 180 ccttacctgc ttgtgccact cagttgtgtt gctttatcat gtttgtggtc tgtgaagtgt 240 atatgctctc aatcatggcg tatgataggt atgtagccat ttctaaacct ttactgtata 300 ccgttatcat gaacagaagg gtctgtattc aaatggtggt cactacacat ttgtatggct 360 tttctgtggg actcctccag gcaattctaa cattccactt acctttctgt aatgcaaaca 420 taataaatca cttctactgt gatgatgttc cctggttggt ctggcctgcc gtaaaaccca 480 ttataaagat atcaaagaac tgatatggtt cacacttgct gctttcaata cccttttctc 540 tctctttatc gtcctcatct cctgcatagt cattctattt gccattctga ggattcattc 600 agcagaaggc cgacaaaagg cattttctac ttgtgcctcc cacctgactt catcaccatg 660 ttttatggta ccgtcatctt catgtatatg cagccgaaac aagccattct ctggatactg 720 acaaaatagc ttctgttttc tatattgtgg tgatccccac gatgaatcct ttaatataca 780 gcctgaggaa ccaggaagtc aaaatgcttt gaagaga 817

<210> 3016 <211> 166 <212> PRT <213> Felis catus <400> 3016

Ile Tyr Leu Ile Ser Val Ile Gly Asn Leu Gly Leu Ile Met Leu Ile 1 5 10 15 Tyr Thr Arg Ser Gln Leu His Thr Pro Met Tyr Ser Phe Val Ser Asn 20 25 30

Page 3363

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Leu Ala Phe Val Ala Phe Cys Tyr Thr Ser Ser Val Thr Pro Asn Thr 35 40 45 Leu Val Asn Phe Leu Gln Glu Ile Lys Arg Ile Ser Leu Pro Ala Cys 50 55 60 Ala Thr Gln Leu Cys Cys Phe Ile Met Phe Val Val Cys Glu Val Tyr 65 70 75 80 Met Leu Ser Ile Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser Lys Pro 85 90 95 Leu Leu Tyr Thr Val Ile Met Asn Arg Arg Val Cys Ile Gln Met Val 100 105 110 Val Thr Thr His Leu Tyr Gly Phe Ser Val Gly Leu Leu Gln Ala Ile 115 120 125 Leu Thr Phe His Leu Pro Phe Cys Asn Ala Asn Ile Ile Asn His Phe 130 135 140 Tyr Cys Asp Asp Val Pro Trp Leu Val Trp Pro Ala Val Lys Pro Ile 145 150 155 160 Ile Lys Ile Ser Lys Asn

165 <210> 3017 <211> 922 <212> DNA <213> Felis catus <400> 3017 atggcaaaag gcaatcagtc agcagtcact gagtttattc tcttgggcct cacagataat ccagagtttc aggccatcct cttttgtgta ttcctattga tttactcagt tactctcctg ggtaatcttg gcttgattgt gttaatccaa ataagtcccc agcttcacac acccatgtat tttttcctct gtcatctggc ttttgttgat ttttatggtg cctccaccat tactccaaac acccttgcaa actcgttacg tgaaattaaa actatgccat tttatgcatg tgccactcaa

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gtgtgttgct ttatcacatt ttcagtttgg gaattattaa tgctgtctgt catggcctat 360 gatcgctatg tggccatctg caacccttta ctctaagtca ttctcatgcc caggaaactc 420 tgcttccaaa tggtcactag ctcttatatt tatggactca ctgtaggact cgtacaagca 480 gtggctacat tccacatgtc tttctgtgac tctaatgtgg tcaaccagtt ctactgtgat 540 gatgtcccct tgattgctct ggcttgctct gatacccaag tcaaagagtt gatgctgtgg 600 atcattgctg ggttcaatgt gttcttttct cttatcattg ttctcatatc ctatgtgttc 660 gttgtcttca ccatcttgaa gatccattct gctgcaggaa gacataaagc cttttccacc 720 tgcgcttctc acctgttttc tattaccatg tattatggga ccctcagttt tatgtacctg 780 cgccccaagt caagccactc actggataaa gacaaatttg cctcagtgtt ctatgcagtg 840 gtgattccca tgttaaaccc attgatctac agcttgagga atcaggatgt aaaaaaggct 900 ctcaagaaaa tctttgacaa ag 922

<210> 3018 <211> 173 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (173)..(173) <223> Any amino acid <400> 3018

Met Pro 1 Arg Lys Leu 5 Cys Phe Gln Met Val Thr Ser Ser Tyr Ile Tyr 10 15 Gly Leu Thr Val Gly Leu Val Gln Ala Val Ala Thr Phe His Met Ser 20 25 30 Phe Cys Asp Ser Asn Val Val Asn Gln Phe Tyr Cys Asp Asp Val Pro 35 40 45 Leu Ile Ala Leu Ala Cys Ser Asp Thr Gln Val Lys Glu Leu Met Leu 50 55 60

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Trp Ile Ile Ala Gly Phe Asn Val Phe Phe Ser Leu Ile Ile Val Leu 65 70 75 80 Ile Ser Tyr Val Phe Val Val Phe Thr Ile Leu Lys Ile His Ser Ala 85 90 95 Ala Gly Arg His Lys Ala Phe Ser Thr Cys Ala Ser His Leu Phe Ser 100 105 110 Ile Thr Met Tyr Tyr Gly Thr Leu Ser Phe Met Tyr Leu Arg Pro Lys 115 120 125 Ser Ser His Ser Leu Asp Lys Asp Lys Phe Ala Ser Val Phe Tyr Ala 130 135 140 Val Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Gln 145 150 155 160 Asp Val Lys Lys Ala Leu Lys Lys Ile Phe Asp Lys Xaa

165 170 <210> 3019 <211> 960 <212> DNA <213> Felis catus <400> 3019

ttattttctt aactttaaca gctttaaggt ttcacaacct ttatccaagg ctttccttga 60 agcatcttta acctctttgt tccttagact atagatcagg gggttcaaca tcgggatcac 120 caccgtgtag aatacagacg ccattttgtc cgtgtccagg gagtgatttg atttgggctg 180 taggtacata aagatcaagg tgccgtagaa aatagtgaca gtcaccatat gggagccaca 240 ggtggaaatg gccttgcgtc gcccctgagt agagcggatc cttaagatgg cagcaatgat 300 aaagatgtag gaggtgagaa caatggaaga ggagcagatc atatcaaaac cagcaaaggc 360 aaagatcaga atttccttca cgtgtgtgtc tgagcaggac agagccaaga gaggaaggtc 420 atcacagtag aaatggttaa ttacattggg gccacagtaa gttagatgga aggtgataat 480 ggtatggaat agggcaacca gaaagctgta tatatatgga actgccacta attgaatgca 540

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gagtcttttt gacatcaggg ttgaatagtg caggggacta cagatggcca cgtagcgatc 600 ataggccata gaagccaaca ggaaacactc ggtgatcatg aaggtgagaa agcagcccag 660 ttgtgttgca caagcataga aaggaatagc gttgatttcc acaacaaaat tcaccatcat 720 ctttggtgtg atagcagagg agtagcaaag gtcaacaaag gccaagtgac tgaggaaata 780 gtacataggc gagtggagtc gaacatcaat cctgattaaa gttatcaacc ccatgttgcc 840 cagcactgtg accagataga tgatgaaaaa caccacaaag catggggcct gaagctctgg 900 ttggtctgtg attccctgga gaatgaattc agtgacatgg gtgatattgg tctcagccat 960

<210> 3020 <211> 319 <212> PRT <213> Felis catus

<400> 3020 Ile Thr His Val Thr Glu Phe Ile Leu Gln Gly Met 1 Ala Glu Thr Asn 5 10 15 Ile Thr Asp Gln Pro Glu Leu Gln Ala Pro Cys Phe Val Val Phe Phe 20 25 30 Ile Ile Tyr Leu Val Thr Val Leu Gly Asn Met Gly Leu Ile Thr Leu 35 40 45 Ile Arg Ile Asp Val Arg Leu His Ser Pro Met Tyr Tyr Phe Leu Ser 50 55 60 His Leu Ala Phe Val Asp Leu Cys Tyr Ser Ser Ala Ile Thr Pro Lys 65 70 75 80 Met Met Val Asn Phe Val Val Glu Ile Asn Ala Ile Pro Phe Tyr Ala 85 90 95 Cys Ala Thr Gln Leu Gly Cys Phe Leu Thr Phe Met Ile Thr Glu Cys 100 105 110 Phe Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125

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Pro Leu 130 His Tyr Ser Thr Leu Met Ser Lys Arg Leu Cys Ile Gln Leu 135 140 Val Ala Val Pro Tyr Ile Tyr Ser Phe Leu Val Ala Leu Phe His Thr 145 150 155 160 Ile Ile Thr Phe His Leu Thr Tyr Cys Gly Pro Asn Val Ile Asn His 165 170 175 Phe Tyr Cys Asp Asp Leu Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 His Val Lys Glu Ile Leu Ile Phe Ala Phe Ala Gly Phe Asp Met Ile 195 200 205 Cys Ser Ser Ser Ile Val Leu Thr Ser Tyr Ile Phe Ile Ile Ala Ala 210 215 220 Ile Leu Arg Ile Arg Ser Thr Gln Gly Arg Arg Lys Ala Ile Ser Thr 225 230 235 240 Cys Gly Ser His Met Val Thr Val Thr Ile Phe Tyr Gly Thr Leu Ile 245 250 255 Phe Met Tyr Leu Gln Pro Lys Ser Asn His Ser Leu Asp Thr Asp Lys 260 265 270 Met Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Ser Arg Lys Ala 290 295 300 Leu Asp Lys Gly Cys Glu Thr Leu Lys Leu Leu Lys Leu Arg Lys

305 310 315 <210> 3021 <211> 957 <212> DNA

Page 3368

069269_0225_SL.TXT <213> Felis catus <400> 3021 atggttgaaa ggaataacac cagggtgaca gaattcattc ttttgggctt ttctgtccat 60 agagagattg aaatcactct cttttttctc atttcagtag tatatactct aactttggta 120 gggaaccttg ggatgatttc attaatacga ttggattctc gacttcacac acccatgtac 180 ttttttctca gcaatctggc ctttgtagac ctctgttact cttcatcaat agcccccaag 240 ttcctgcaga ccctcctgac caagcacaag tctatatctt tctacgcatg tgcaacacag 300 ttgggctttt tcctgaactt cttgatttca gagatgctcc ttcttgcagt gatggcttat 360 gaccgctatg tggccatctg caatcctctt ctctacatgg tgagcatgtc cccaaaagtg 420 tgtatgcaac tagtaacagg cccctactta tacagctttt ctgttgcttt gctccacaca 480 gccgttactt tccaactgat ttattgtggc ccaaatatca tcaatcactt ttattgcgat 540 gatgtccctt tgatggccct cgcctgctca gacaccagtc tcaaagaaat cttgattttc 600 atctttgcgg gtttcaacat gatcagctct ttgagcactg ttcttatttc ttacttatac 660 atcgtggctg ccatcttgaa aatccaatct acagaaggaa ggttcagagc tttctcaacc 720 tgcgcgtctc atctgactgc tgtgactata ttctatggga ctctgatctt catgtatctg 780 cagcccaaat caaaccattc ccttgacaca gacaaaatgg cctctgtgtt ctacacaatt 840 gtaattccta tgctgaaccc aatgatctat agcttgagga acaaagaggt gaaaaatgcc 900 ttgaggaaat caattgacaa atgttacatc ctgcttctaa caaactttaa aaaatga 957 <210> 3022 <211> 318 <212> PRT <213> Felis catus

<400> 3022 Asn Thr Arg Val Thr Glu Phe Ile Leu Leu Gly Met 1 Val Glu Arg Asn 5 10 15 Phe Ser Val His Arg Glu Ile Glu Ile Thr Leu Phe Phe Leu Ile Ser 20 25 30 Val Val Tyr Thr Leu Thr Leu Val Gly Asn Leu Gly Met Ile Ser Leu 35 40 45

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Ile Arg 50 Leu Asp Ser Arg Leu His 55 Thr Pro Met Tyr Phe Phe Leu 60 Ser Asn Leu Ala Phe Val Asp Leu Cys Tyr Ser Ser Ser Ile Ala Pro Lys 65 70 75 80 Phe Leu Gln Thr Leu Leu Thr Lys His Lys Ser Ile Ser Phe Tyr Ala 85 90 95 Cys Ala Thr Gln Leu Gly Phe Phe Leu Asn Phe Leu Ile Ser Glu Met 100 105 110 Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Met Val Ser Met Ser Pro Lys Val Cys Met Gln Leu 130 135 140 Val Thr Gly Pro Tyr Leu Tyr Ser Phe Ser Val Ala Leu Leu His Thr 145 150 155 160 Ala Val Thr Phe Gln Leu Ile Tyr Cys Gly Pro Asn Ile Ile Asn His 165 170 175 Phe Tyr Cys Asp Asp Val Pro Leu Met Ala Leu Ala Cys Ser Asp Thr 180 185 190 Ser Leu Lys Glu Ile Leu Ile Phe Ile Phe Ala Gly Phe Asn Met Ile 195 200 205 Ser Ser Leu Ser Thr Val Leu Ile Ser Tyr Leu Tyr Ile Val Ala Ala 210 215 220 Ile Leu Lys Ile Gln Ser Thr Glu Gly Arg Phe Arg Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Leu Ile 245 250 255

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Phe Met Tyr Leu Gln Pro Lys Ser Asn 265 His Ser Leu Asp Thr 270 Asp Lys 260 Met Ala Ser Val Phe Tyr Thr Ile Val Ile Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Leu Arg Lys Ser 290 295 300 Ile Asp Lys Cys Tyr Ile Leu Leu Leu Thr Asn Phe Lys Lys 305 310 315

<210> 3023 <211> 927 <212> DNA <213> Felis catus <400> 3023 ccccacattt gccttggcaa ttgctttgtt gactgcctct ctcacatcct tgttcctcag actgtagatc atgggattca gcatggggat cactgtggta tagaacacgg ccaccatttt cccctgctcc acggactctt cagtgggacg cctgaggtac atgaatatga gagtcccata aaacagggtc acagctgtca agtgggaccc acaggtggag aacgccttct tcctgccctc agcagagtgc atccgtagca cggtgactac aatgagggtg taggatgtga ggaccacaga gagagaatat gtgaagttta ttccagcaat aacaatcatc gtgtattctt tgatgtggac ccccccacag gcaatcttga tgagaggagg gtctgcacaa tagaagtggt tgatttcaaa gtttccacag aagtacaatc catatgtcca gagggtacat attaagctaa cagagaatcc atagacgtaa ggcacagaga taagtcgaac acagacaatc ctggacattc tactgccata aagcaacggc ttgcagatgg ccatgtagcg atcaaaggcc atcactgcca agatatagac ctccacgtgg acaagggcaa tgaaaaagta gcactgcacc aaacacccca cataggaaat agtttttgtc tctgacaata aattttccag cattttgggg gtgacattgg aagagaacca cacgtcgaca aaagacaaat ggctcaagaa aaagtacata gggctctgaa gctgaggact gatgctgatc agaatgatca taccaacgtt ccctaaaaga gtgatcatgt aaactactag

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900

927

069269_0225_SL.TXT gaatatcaca aaaaagagaa cttgaaattc ctgacgactg gccaagccca gaagaacaaa ttctgtcaca tccgtgaaat ttggcat <210> 3024 <211> 309 <212> PRT <213> Felis catus

<400> 3024 Asp Val Thr Met 1 Pro Asn Phe Thr 5 Ser Arg Gln Glu 20 Phe Gln Val Leu Tyr Met Ile 35 Thr Leu Leu Gly Asn 40 Ile Ser 50 Pro Gln Leu Gln Ser 55 Pro Ser 65 Phe Val Asp Val Trp 70 Phe Ser Glu Asn Leu Leu Ser 85 Glu Thr Lys Val Gln Cys Tyr 100 Phe Phe Ile Ala Leu Ala Val 115 Met Ala Phe Asp Arg 120 Leu Tyr 130 Gly Ser Arg Met Ser 135 Arg Val 145 Pro Tyr Val Tyr Gly 150 Phe Ser Thr Tyr Gly Leu Tyr Phe Cys Gly

Glu Phe 10 Val Leu Leu Gly Leu 15 Ala Phe 25 Phe Val Ile Phe Leu 30 Val Val Val Gly Met Ile Ile 45 Leu Ile Ser Met Tyr Phe Phe 60 Leu Ser His Leu Ser Asn Val 75 Thr Pro Lys Met Leu 80 Thr Ile 90 Ser Tyr Val Gly Cys 95 Leu Leu 105 Val His Val Glu Val 110 Tyr Ile Tyr Met Ala Ile Cys 125 Lys Pro Leu Ile Val Cys Val 140 Arg Leu Ile Ser Val Ser Leu 155 Ile Cys Thr Leu Trp 160 Asn Phe Glu Ile Asn His Phe Tyr

Page 3372

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165 170 175

Cys Ala Asp Pro Pro Leu Ile Lys Ile Ala Cys Gly Gly Val His Ile 180 185 190 Lys Glu Tyr Thr Met Ile Val Ile Ala Gly Ile Asn Phe Thr Tyr Ser 195 200 205 Leu Ser Val Val Leu Thr Ser Tyr Thr Leu Ile Val Val Thr Val Leu 210 215 220 Arg Met His Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Thr Leu Ile Phe Met 245 250 255 Tyr Leu Arg Arg Pro Thr Glu Glu Ser Val Glu Gln Gly Lys Met Val 260 265 270 Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Arg Glu Ala Val Asn Lys Ala Ile Ala 290 295 300 Lys Ala Asn Val Gly

305 <210> 3025 <211> 933 <212> DNA <213> Felis catus <400> 3025 ttattttgtt aagcatgttc tgctggccac tttgctcatg gcttctttca catccttgtt cctcaaactg tagatcatgg gattcagcat ggggatcact gtggtataaa acacagccac cattttcccc tgctccacgg actcttctgt gggacgcctg agatacatga atatgagagt cccataaaat atgacgacag cggtcaagtg ggacccacag gtggaaaagg ccttccgcct

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069269_0225_SL.TXT cccttcggct gagtgcatcc gtagaatggc aatgagaatg aacagataag aaatggtgac gacactcaga gaatatgtga agttaatgcc tgcaagtatg atcattgtat attcttttac gaaggtccca gcgcacgcca ttttgatgag aggtgggtct gcacagtaga agtggttgat ctcaattctc ccacaaaagt acaagccata tgtccagagg gttgctgcca gactagtcag aaaaccatat atgtaaggga aagaaatcag tcgaatacag actgttctag acattttgct gccatagagc agagggttcc caattgccat atacctatca aaggccatca cagcaagaat aaaaatttct acatggacaa gggcaatgaa aaagaaacat tgcaccaaac aaccagcata ggaaatagtt tttgtctctg ataacagatt ttccagcatt ttaggggtga cattggagga aaaccacaca tcaacaaatg acaaatgact gagaaaaaag tacatggggc tgttaagctg tggactgatc ttaattaaca taatcatgcc aatgttgccc accaccgtga caatatagac cgcaagaaaa atgacgaaga agagaacttg ccattcctga tgactggtta atcccaaaag aataaactct gtcacatcgg tgaaattgag cat <210> 3026 <211> 310 <212> PRT <213> Felis catus <400> 3026

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933

Met 1 Leu Asn Phe Thr Asp 5 Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 10 15 Ser His Gln Glu Trp Gln Val Leu Phe Phe Val Ile Phe Leu Ala Val 20 25 30 Tyr Ile Val Thr Val Val Gly Asn Ile Gly Met Ile Met Leu Ile Lys 35 40 45 Ile Ser Pro Gln Leu Asn Ser Pro Met Tyr Phe Phe Leu Ser His Leu 50 55 60 Ser Phe Val Asp Val Trp Phe Ser Ser Asn Val Thr Pro Lys Met Leu 65 70 75 80

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Glu Asn Leu Leu Ser 85 Glu Thr Lys Thr Ile Ser Tyr Ala Gly Cys Leu 90 95 Val Gln Cys Phe Phe Phe Ile Ala Leu Val His Val Glu Ile Phe Ile 100 105 110 Leu Ala Val Met Ala Phe Asp Arg Tyr Met Ala Ile Gly Asn Pro Leu 115 120 125 Leu Tyr Gly Ser Lys Met Ser Arg Thr Val Cys Ile Arg Leu Ile Ser 130 135 140 Phe Pro Tyr Ile Tyr Gly Phe Leu Thr Ser Leu Ala Ala Thr Leu Trp 145 150 155 160 Thr Tyr Gly Leu Tyr Phe Cys Gly Arg Ile Glu Ile Asn His Phe Tyr 165 170 175 Cys Ala Asp Pro Pro Leu Ile Lys Met Ala Cys Ala Gly Thr Phe Val 180 185 190 Lys Glu Tyr Thr Met Ile Ile Leu Ala Gly Ile Asn Phe Thr Tyr Ser 195 200 205 Leu Ser Val Val Thr Ile Ser Tyr Leu Phe Ile Leu Ile Ala Ile Leu 210 215 220 Arg Met His Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Ala Val Val Ile Phe Tyr Gly Thr Leu Ile Phe Met 245 250 255 Tyr Leu Arg Arg Pro Thr Glu Glu Ser Val Glu Gln Gly Lys Met Val 260 265 270 Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met Ile Tyr 275 280 285

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Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Met Ser Lys Val Ala Ser 290 295 300

Arg Thr Cys Leu Thr Lys 305 310 <210> 3027 <211> 936 <212> DNA <213> Felis catus <400> 3027

ttaagaaaat cttttttttc ttatcaactc tttggttaat gcttctttca catctttatt 60 cctaaggcta taaatcatgg ggttcaacat gggaattacc gttgtataaa atacagcaac 120 catttttccc tgttccacag attcctttga agggggtcta agatacatga agaaaagagt 180 tgcatagaat atggtgacag ctatcagatg ggagccacag gtggaaaaag ctttgtgcct 240 gccttctgtg gaacgaatcc tcaggatagc aggaaaaata taaaggtagg atatcaagat 300 gatgaggaga gaaaaggaga ggttacatcc agccacaaca aacatggaca gctctttgtt 360 ggaagtgtca gaacaagcca gcttaatcag tggtgggtca gcacagtaga agtggttaat 420 ttcattgggg ccacagaagg ctaggttgta agtccacatg gtttccatga ggccagtgag 480 cgctccatac acataaggcc cggtgatgag ggatgtgcac acactcttgg acatcttgct 540 gccataaagc agagggttgc agatggccat gtaccgatca aaggccatca cagccaggat 600 gtagatctcc acgtggacca aggcaataaa aaagtaacac tgcaccagac atgcagggta 660 agaaatagtt ttcttctccg acaagaaaat ctccagcatc tttggagtca cattggaaga 720 gaaacacaga tccacaaagg ataagtggct cagaaaaaag tacatgggtt tgtgcagccg 780 ggcattgacc tggatgagta caatcatgcc gagattccct gcgactgtgg ccgtgtaaat 840 ggccagaaac agcaggaaga ggagaatctg taattccagg tgactggtca gtccaagaag 900 aatgaactca ttcactgagg tgaaatttct tctcat 936

<210> 3028 <211> 311 <212> PRT <213> Felis catus

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<400> 3028 Phe Ile Leu Leu Gly 15 Leu Met 1 Arg Arg Asn Phe Thr 5 Ser Val Asn Glu 10 Thr Ser His Leu Glu Leu Gln Ile Leu Leu Phe Leu Leu Phe Leu Ala 20 25 30 Ile Tyr Thr Ala Thr Val Ala Gly Asn Leu Gly Met Ile Val Leu Ile 35 40 45 Gln Val Asn Ala Arg Leu His Lys Pro Met Tyr Phe Phe Leu Ser His 50 55 60 Leu Ser Phe Val Asp Leu Cys Phe Ser Ser Asn Val Thr Pro Lys Met 65 70 75 80 Leu Glu Ile Phe Leu Ser Glu Lys Lys Thr Ile Ser Tyr Pro Ala Cys 85 90 95 Leu Val Gln Cys Tyr Phe Phe Ile Ala Leu Val His Val Glu Ile Tyr 100 105 110 Ile Leu Ala Val Met Ala Phe Asp Arg Tyr Met Ala Ile Cys Asn Pro 115 120 125 Leu Leu Tyr Gly Ser Lys Met Ser Lys Ser Val Cys Thr Ser Leu Ile 130 135 140 Thr Gly Pro Tyr Val Tyr Gly Ala Leu Thr Gly Leu Met Glu Thr Met 145 150 155 160 Trp Thr Tyr Asn Leu Ala Phe Cys Gly Pro Asn Glu Ile Asn His Phe 165 170 175 Tyr Cys Ala Asp Pro Pro Leu Ile Lys Leu Ala Cys Ser Asp Thr Ser 180 185 190 Asn Lys Glu Leu Ser Met Phe Val Val Ala Gly Cys Asn Leu Ser Phe 195 200 205

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Ser Leu Leu Ile Ile Leu Ile Ser Tyr Leu Tyr Ile Phe Pro Ala Ile 210 215 220 Leu Arg Ile Arg Ser Thr Glu Gly Arg His Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Ser His Leu Ile Ala Val Thr Ile Phe Tyr Ala Thr Leu Phe Phe 245 250 255 Met Tyr Leu Arg Pro Pro Ser Lys Glu Ser Val Glu Gln Gly Lys Met 260 265 270 Val Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Thr Lys Glu Leu 290 295 300 Ile Arg Lys Lys Arg Phe Ser

305 310

<210> 3029 <211> 957 <212> DNA <213> Felis catus <400> 3029 ttatttcaaa agtacatttc ttctcatcaa tttccaaaaa gcttgcttca cattcttgtt 60 cctcaggcta taaatgatgg ggttcaacat agggcttaca aaagtgtaga aaacagcaat 120 aattttagac tgctccactg acttgtccgt gggaggtcta acatacatgc agaagagtgt 180 cccgtaaaat acagtcactg ccaccagatg ggaaccacac gtggaaaaag ctttgtgcct 240 gccttcagca gaatgtatcc tcaggatggc agtgagaatg aagatgtaag agatgacaat 300 tatgaggagg gagttggaga ggttaaatcc tgctaccaca aacatggacg tctctttaat 360 gaaagtgtca gagcaggaca gctggatgag gggggggtca gcgcagtaga agtgattaat 420 aatattggag tcacagaagg tcaagcggta cgtccacatg gtttccatca ggccactaag 480 gaagccgtag acatagggac cagcaatcag gcgaatacag acccctctgg acatcttgct 540

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gctgtaaagc aaagggttac agatggccac gtacctgtca taagccatta cagccagcat 600 gtaatactca gtaatcacca tggcaatgaa aaaataacac tgggttaaac aagcagcata 660 ggaaatggtt ttcttctctg ataagaagtt cgccaacatc ttgggagtca cattcgtgga 720 ataacacaaa tccaagccgg acaaactggc gagaaagaag tacatggggg tgtggaggcg 780 tgaatctatc ctgatcaata ccaacatccc aaggttcccc cccacggtga tcaagtagat 840 caccaggaac agcacaaaga ggatgggctg aagctctgga cgatctgtta atcccaggag 900 aacaaattcg gtcactaagg tggaatttcc tctgaccatt ttcttagctg ccagcat 957

<210> 3030 <211> 318 <212> PRT <213> Felis catus

<400> 3030 Val Arg Gly Asn Ser Thr Leu Val Thr Met 1 Leu Ala Ala Lys 5 Lys Met 10 15 Glu Phe Val Leu Leu Gly Leu Thr Asp Arg Pro Glu Leu Gln Pro Ile 20 25 30 Leu Phe Val Leu Phe Leu Val Ile Tyr Leu Ile Thr Val Gly Gly Asn 35 40 45 Leu Gly Met Leu Val Leu Ile Arg Ile Asp Ser Arg Leu His Thr Pro 50 55 60 Met Tyr Phe Phe Leu Ala Ser Leu Ser Gly Leu Asp Leu Cys Tyr Ser 65 70 75 80 Thr Asn Val Thr Pro Lys Met Leu Ala Asn Phe Leu Ser Glu Lys Lys 85 90 95 Thr Ile Ser Tyr Ala Ala Cys Leu Thr Gln Cys Tyr Phe Phe Ile Ala 100 105 110 Met Val Ile Thr Glu Tyr Tyr Met Leu Ala Val Met Ala Tyr Asp Arg 115 120 125

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Tyr Val 130 Ala Ile Cys Asn Pro Leu Leu Tyr Ser Ser Lys Met Ser Arg 135 140 Gly Val Cys Ile Arg Leu Ile Ala Gly Pro Tyr Val Tyr Gly Phe Leu 145 150 155 160 Ser Gly Leu Met Glu Thr Met Trp Thr Tyr Arg Leu Thr Phe Cys Asp 165 170 175 Ser Asn Ile Ile Asn His Phe Tyr Cys Ala Asp Pro Pro Leu Ile Gln 180 185 190 Leu Ser Cys Ser Asp Thr Phe Ile Lys Glu Thr Ser Met Phe Val Val 195 200 205 Ala Gly Phe Asn Leu Ser Asn Ser Leu Leu Ile Ile Val Ile Ser Tyr 210 215 220 Ile Phe Ile Leu Thr Ala Ile Leu Arg Ile His Ser Ala Glu Gly Arg 225 230 235 240 His Lys Ala Phe Ser Thr Cys Gly Ser His Leu Val Ala Val Thr Val 245 250 255 Phe Tyr Gly Thr Leu Phe Cys Met Tyr Val Arg Pro Pro Thr Asp Lys 260 265 270 Ser Val Glu Gln Ser Lys Ile Ile Ala Val Phe Tyr Thr Phe Val Ser 275 280 285 Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asn Val Lys 290 295 300 Gln Ala Phe Trp Lys Leu Met Arg Arg Asn Val Leu Leu Lys

305 310 315 <210> 3031 <211> 967

Page 3380

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 3031 atttcaaatg aacagataac caaatttcaa ttttatgaaa gagatttccc tgaatgattt 60 gctgcatagc atggaccaca tccttgttcc gtagactata aatcaatggg ttcaacattg 120 ggctcaagaa agtataaaag actgcaatta ttttggactc ctccacagac ttctcagatg 180 gggtccttaa gtacatgcag aagagggttc cataaaatag ggtgactgtt gtcaagtggg 240 aaccacaagt agaaaaggct ctgtgcctgc cttcagcaga atggatcctc aagatggctg 300 caataatgag aaggtaggaa aggacaatga tgaagagaga gcttgacaga gtcaagccag 360 cgactacaaa cattgccatt tttttgacat aagtgtcaga gcaggccaat agtataagag 420 gaggatctgc acagtagaaa tgattgattt caagggagcc acagaaggac aagtgaaaag 480 tcagcagtgt ctgggagagt ccattaagga agccacaagt ataagacacc atgactagag 540 agatacaaac attcttagac attctggtac tgtaatgtag agggctacaa atggctacat 600 agcgatccaa tgccatcgaa gcaaggatat aaaactcagt gatcaccagg gcaatgaaga 660 gaagacactg tgtgaagcat ccagcatagg agatggtctt ctggtcggag aggaagttgt 720 acagcatgtt tggagtgata ttggaggaat agcaaatgtc cacgaaggag aggtggctaa 780 ggaagaagta catgggtgtt tggaggtgag aattggtcct gatcagcata atcatgcaga 840 gattgcctgc cagcgtgatc aggtagatca ccagaaacac cccaaacagg atcttctcca 900 ggacagggtc gtctgtgagt cccaagagaa tgaattctgc cactgtagtg tggtttgggg 960 aagacat 967 <210> 3032 <211> 323 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (323)..(323) <223> Any amino acid <400> 3032

Met Ser Ser Pro Asn His Thr Thr Val Ala Glu Phe Ile Leu Leu Gly Page 3381

069269_0225_SL.TXT

1 5 10 15 Leu Thr Asp Asp Pro Val Leu Glu Lys Ile Leu Phe Gly Val Phe Leu 20 25 30 Val Ile Tyr Leu Ile Thr Leu Ala Gly Asn Leu Cys Met Ile Met Leu 35 40 45 Ile Arg Thr Asn Ser His Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Asn Ile Thr Pro Asn 65 70 75 80 Met Leu Tyr Asn Phe Leu Ser Asp Gln Lys Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Phe Thr Gln Cys Leu Leu Phe Ile Ala Leu Val Ile Thr Glu Phe 100 105 110 Tyr Ile Leu Ala Ser Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu His Tyr Ser Thr Arg Met Ser Lys Asn Val Cys Ile Ser Leu 130 135 140 Val Met Val Ser Tyr Thr Cys Gly Phe Leu Asn Gly Leu Ser Gln Thr 145 150 155 160 Leu Leu Thr Phe His Leu Ser Phe Cys Gly Ser Leu Glu Ile Asn His 165 170 175 Phe Tyr Cys Ala Asp Pro Pro Leu Ile Leu Leu Ala Cys Ser Asp Thr 180 185 190 Tyr Val Lys Lys Met Ala Met Phe Val Val Ala Gly Leu Thr Leu Ser 195 200 205 Ser Ser Leu Phe Ile Ile Val Leu Ser Tyr Leu Leu Ile Ile Ala Ala

Page 3382

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210 215 220

Ile 225 Leu Arg Ile His Ser Ala Glu Gly Arg His Arg Ala Phe Ser Thr 230 235 240 Cys Gly Ser His Leu Thr Thr Val Thr Leu Phe Tyr Gly Thr Leu Phe 245 250 255 Cys Met Tyr Leu Arg Thr Pro Ser Glu Lys Ser Val Glu Glu Ser Lys 260 265 270 Ile Ile Ala Val Phe Tyr Thr Phe Leu Ser Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Val His Ala Met Gln Gln Ile 290 295 300 Ile Gln Gly Asn Leu Phe His Lys Ile Glu Ile Trp Leu Ser Val His 305 310 315 320

Leu Lys Xaa <210> 3033 <211> 917 <212> DNA <213> Felis catus <400> 3033

gttgttttaa aaattttacc tgaggaagct ttgacgtcct tagttctcag actctagatg 60 aaaggattta acatgggaat gatcactgta taaaacacag ataccacttt gtcttggtcc 120 cttgagtagc agaagctgga gcgcagatac atgaacagaa tagtgccaaa gaaaatggtg 180 atcaccatca agcgggaagc gcaggtggag aaagccttgt gcctcccttc agcagaatgg 240 atcctcaagg cggcaatgag gatgtacaga taagaactga gaataatcag gaggcagctc 300 agttcattac aactggcaaa agcaaaaatg acaacttcat tgacacgtgt atcagaacaa 360 gagagtttca ggaggggtgg agtgtcacag aaaaagtggt tgatgacatt caagtggcag 420 aaagacagct gaaaggtgaa gcctgggtga atggcagcct tcagaaagcc tgcaagatac 480

Page 3383

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gcggccaata ccagaaggac attaagacgc agggacgtgg tgactgtgta aagaagaggc 540 ttgcagatga ccacgtaacg gtcataggcc atcacagcca acagaaagcc ctcaattcca 600 gcaaaggaac caaaaaagaa gaactgcgtg gcacatgcac taaatgaaat gactgggttc 660 tccagccaga aattcattag catattaggg gcaatgacag aagaataaca gaagtcaaca 720 agggataaat tactgaagaa aaagcacatt ggggtatgga gatgtgagtc actcttgatt 780 aataggatca tgccaagatt tccaaacaca gttatcatat agatgactag aaacaccata 840 aaaagaagaa actgtagttc tggatgatcc ctgaatccca tgagaataaa ttcagccact 900 gttgtatggt tgctcat 917

<210> 3034 <211> 287 <212> PRT <213> Felis catus

<400> 3034 Thr Val Ala Glu Phe Ile Leu Met Gly Phe Arg Met Ser 1 Asn His Thr 5 10 15 Asp His Pro Glu Leu Gln Phe Leu Leu Phe Met Val Phe Leu Val Ile 20 25 30 Tyr Met Ile Thr Val Phe Gly Asn Leu Gly Met Ile Leu Leu Ile Lys 35 40 45 Ser Asp Ser His Leu His Thr Pro Met Cys Phe Phe Phe Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Cys Tyr Ser Ser Val Ile Ala Pro Asn Met Leu 65 70 75 80 Met Asn Phe Trp Leu Glu Asn Pro Val Ile Ser Phe Ser Ala Cys Ala 85 90 95 Thr Gln Phe Phe Phe Phe Gly Ser Phe Ala Gly Ile Glu Gly Phe Leu 100 105 110

Page 3384

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Leu Ala Val Met Ala Tyr Asp Arg 120 Tyr Val Val Ile Cys 125 Lys Pro Leu 115 Leu Tyr Thr Val Thr Thr Ser Leu Arg Leu Asn Val Leu Leu Val Leu 130 135 140 Ala Ala Tyr Leu Ala Gly Phe Leu Lys Ala Ala Ile His Pro Gly Phe 145 150 155 160 Thr Phe Gln Leu Ser Phe Cys His Leu Asn Val Ile Asn His Phe Phe 165 170 175 Cys Asp Thr Pro Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr Arg Val 180 185 190 Asn Glu Val Val Ile Phe Ala Phe Ala Ser Cys Asn Glu Leu Ser Cys 195 200 205 Leu Leu Ile Ile Leu Ser Ser Tyr Leu Tyr Ile Leu Ile Ala Ala Leu 210 215 220 Arg Ile His Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser Arg Leu Met Val Ile Thr Ile Phe Phe Gly Thr Ile Leu Phe Met 245 250 255 Tyr Leu Arg Ser Ser Phe Cys Tyr Ser Arg Asp Gln Asp Lys Val Val 260 265 270 Ser Val Phe Tyr Thr Val Ile Ile Pro Met Leu Asn Pro Phe Ile 275 280 285

<210> 3035 <211> 948 <212> DNA <213> Felis catus <400> 3035 ttacagcatg tgtttctgta agatcttctt tagggcccct ttcacatcct tatttttcaa

Page 3385

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actgtagatg agggggttta acataggaat cactactgta taaaagacag agacaatctt 120 ttcctgttcc attgaatagc tagatgtagg gcgcaagtac atgaagagaa ttgtcccaaa 180 aaatatggtg acagccatga ggtgggaggc acaggtggag aaggctttgt gcctgccctc 240 taaagaggga atcctcaaga tggcaatgag gatacacagg taagaaatga gaacaaccat 300 aacacaagtg atgacattaa aactggagaa aaccatgatc acaatgccat tgatgcgagt 360 gtcagagcaa gacagcttga gcaggggtgg ggtgtcacag tagaaatggt tgatcctatt 420 agagccacaa aaggacaatc tgaaagtcat tcctgtgtgt atggctgcat tcccaaagcc 480 tgctaggaaa gacatagcta ctagcaagaa acaaattctc ccagacatga gaactgagta 540 cagcagaggg ttccaaatgg ctgcatagcg atcatatgcc atcatagcca acagaaagca 600 ttcagtcccc aaaaaggaac caaagaagta gaactgggca gcgcatccat taaaagatat 660 ggctttgttc tcagccacaa ggttcaccag catcttagga gtgacagaag aagagtaaga 720 ggcatcaaca aaagagaggc tgctgagaaa gaggtacatt ggagtgtgga gacaaggatc 780 cattttaatt aacaccatca tccctaaatt acccaccatg gttgccatat agattaacag 840 aaacaatcca aagaggacac tctgtagatc tgagttgtct gagagtccta agaggataaa 900 ttctgtcact tctgtttgat ttcgtccttg aacctctttc atatatct 948

<210> 3036 <211> 313 <212> PRT <213> Felis catus <400> 3036

Met 1 Lys Glu Val Gln 5 Gly Arg Asn Gln Thr Glu Val Thr Glu 10 Phe 15 Ile Leu Leu Gly Leu Ser Asp Asn Ser Asp Leu Gln Ser Val Leu Phe Gly 20 25 30 Leu Phe Leu Leu Ile Tyr Met Ala Thr Met Val Gly Asn Leu Gly Met 35 40 45 Met Val Leu Ile Lys Met Asp Pro Cys Leu His Thr Pro Met Tyr Leu 50 55 60

Page 3386

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Phe 65 Leu Ser Ser Leu Ser Phe Val Asp Ala Ser Tyr Ser Ser Ser Val 70 75 80 Thr Pro Lys Met Leu Val Asn Leu Val Ala Glu Asn Lys Ala Ile Ser 85 90 95 Phe Asn Gly Cys Ala Ala Gln Phe Tyr Phe Phe Gly Ser Phe Leu Gly 100 105 110 Thr Glu Cys Phe Leu Leu Ala Met Met Ala Tyr Asp Arg Tyr Ala Ala 115 120 125 Ile Trp Asn Pro Leu Leu Tyr Ser Val Leu Met Ser Gly Arg Ile Cys 130 135 140 Phe Leu Leu Val Ala Met Ser Phe Leu Ala Gly Phe Gly Asn Ala Ala 145 150 155 160 Ile His Thr Gly Met Thr Phe Arg Leu Ser Phe Cys Gly Ser Asn Arg 165 170 175 Ile Asn His Phe Tyr Cys Asp Thr Pro Pro Leu Leu Lys Leu Ser Cys 180 185 190 Ser Asp Thr Arg Ile Asn Gly Ile Val Ile Met Val Phe Ser Ser Phe 195 200 205 Asn Val Ile Thr Cys Val Met Val Val Leu Ile Ser Tyr Leu Cys Ile 210 215 220 Leu Ile Ala Ile Leu Arg Ile Pro Ser Leu Glu Gly Arg His Lys Ala 225 230 235 240 Phe Ser Thr Cys Ala Ser His Leu Met Ala Val Thr Ile Phe Phe Gly 245 250 255 Thr Ile Leu Phe Met Tyr Leu Arg Pro Thr Ser Ser Tyr Ser Met Glu 260 265 270

Page 3387

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Gln Glu Lys Ile Val Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Lys Asn Lys Asp Val Lys Gly Ala Leu 290 295 300 Lys Lys Ile Leu Gln Lys His Met Leu 305 310

<210> 3037 <211> 929 <212> DNA <213> Felis catus <400> 3037

atggataaag aaaaccactc aatggtgacc gagtttatct ttatgggcat cactcaagac 60 cctcagctgc agaccatctt ttttgtggtc ttcctcttga tctacctggt caatgtcgtg 120 gggaacattg gtatgattat cttgatcata acagacactc agcttcacac ccccatgtac 180 tttttcctgt gtaacctctc tttcgttgac ctgggatact cttcagccat cgcccccagg 240 atgctggctg acttcttaac aaagcacaaa gttatctcct tctccagctg tgccacccag 300 tttgctttct tcgtaggttt cgtggatgcc gagtgctatg tcttggccgc catggcctac 360 gaccgtttcg tggccatctg tcgacccctc cactatagca ctctcatgtc caagaaagtt 420 tgtatagctc tcatgctggg ctcttacctg gctggcttgg tgagtttagt agcccacact 480 tccctcacct tcagtttgag ttactgtggt tccaatatta tcaaccactt cttctgtgaa 540 atcccacctc tcttagccct ctcttgctca gacacttaca tcagcgagat cttgctcttt 600 agtctgtgtg gcttcattga attcagcacc atcctcatca tcttcatctc ttatgccttc 660 atcctcgtag caatcatcag aatgcgctca gctgaaggcc gccataaggc tttctccacc 720 tgtgggtctc acctcactgg cgtcaccctt ttttatggca cagtcatgtt tatgtacctg 780 aggccaacat ccagctactc cctggaccaa gacaagtggg cctctgtgtt ctacactatt 840 atcatcccca tgctgaatcc cttgatctac agtttacgga acaaggacgt gaaagctgct 900 ttcaaaaaac taactggaag gaaacctca 929

Page 3388

069269_0225_SL.TXT <210> 3038 <211> 310 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (310)..(310) <223> Any amino acid

<400> 3038 His Ser Met Val Thr Glu Phe Ile Phe Met Gly Met Asp 1 Lys Glu Asn 5 10 15 Ile Thr Gln Asp Pro Gln Leu Gln Thr Ile Phe Phe Val Val Phe Leu 20 25 30 Leu Ile Tyr Leu Val Asn Val Val Gly Asn Ile Gly Met Ile Ile Leu 35 40 45 Ile Ile Thr Asp Thr Gln Leu His Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60 Asn Leu Ser Phe Val Asp Leu Gly Tyr Ser Ser Ala Ile Ala Pro Arg 65 70 75 80 Met Leu Ala Asp Phe Leu Thr Lys His Lys Val Ile Ser Phe Ser Ser 85 90 95 Cys Ala Thr Gln Phe Ala Phe Phe Val Gly Phe Val Asp Ala Glu Cys 100 105 110 Tyr Val Leu Ala Ala Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Ser Thr Leu Met Ser Lys Lys Val Cys Ile Ala Leu 130 135 140 Met Leu Gly Ser Tyr Leu Ala Gly Leu Val Ser Leu Val Ala His Thr 145 150 155 160

Page 3389

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Ser Leu Thr Phe Ser Leu Ser Tyr Cys Gly 170 Ser Asn Ile Ile Asn 175 His 165 Phe Phe Cys Glu Ile Pro Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 Tyr Ile Ser Glu Ile Leu Leu Phe Ser Leu Cys Gly Phe Ile Glu Phe 195 200 205 Ser Thr Ile Leu Ile Ile Phe Ile Ser Tyr Ala Phe Ile Leu Val Ala 210 215 220 Ile Ile Arg Met Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Gly Val Thr Leu Phe Tyr Gly Thr Val Met 245 250 255 Phe Met Tyr Leu Arg Pro Thr Ser Ser Tyr Ser Leu Asp Gln Asp Lys 260 265 270 Trp Ala Ser Val Phe Tyr Thr Ile Ile Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ala Ala Phe Lys Lys Leu 290 295 300 Thr Gly Arg Lys Pro Xaa 305 310 <210> 3039 <211> 930 <212> DNA <213> Felis catus <400> 3039 tgtcttctgt tttgcaatag ctctccttaa agctcctttc acatcttggt tccttaggct atagatcaag gggttgagca taggtgtgat cacagtgtag aacactgcaa tgatcttgcc cccagccctg gaggacttcg actggggtct catgtacatg aagatggcag ttccgtagaa

120

180

Page 3390

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caaggccacc actgtcagat gggaggcaca ggtggacagt gccttgtgcc ttccagaggc 240 tgaccgtatc ctgaggactg atagaaggat tcgggcatag gaaacaacaa tcaggagaaa 300 aggaatgaag acgatgataa tactgaagat gaaaacaacc agctcagtaa atgaggtgtc 360 agtgcaagcc aacctcagga cagaagggac ctcacagaaa aagtgattca ggacattggg 420 cccacagtag ggcaaactca aggtgaggac attgataacc atggagctca ggaagctaat 480 ggaccaagaa atggttgcca attggacaca gacactttgg ttcataatga cagtataatg 540 aagagggtga caaatggcta catatctgtc ataagccatg accccaagga gaacacattc 600 aatcattcca aaggagaggg agaagtacat ctgagtagca cagctagaga atgggatggt 660 ctttttcccc accatgttgg acagcatttg tgggacattg gtggatgtat agcagatatc 720 tagaaaggat aaattagtga ggaagaagta catgggggtt tggagacgag gttctatctg 780 aataacagtg atgattgtaa tattccccac tactgttaat aaatagaaaa acaagaacat 840 aataaaaaga atgagctgca tctttggctg agatgagagg cccaggaaca caaattcagt 900 cacagtgaag tttgttttta tcatatccat 930

<210> 3040 <211> 310 <212> PRT <213> Felis catus <400> 3040

Met Asp Met Ile Lys Thr Asn Phe Thr Val Thr Glu Phe Val Phe Leu 1 5 10 15 Gly Leu Ser Ser Gln Pro Lys Met Gln Leu Ile Leu Phe Ile Met Phe 20 25 30 Leu Phe Phe Tyr Leu Leu Thr Val Val Gly Asn Ile Thr Ile Ile Thr 35 40 45 Val Ile Gln Ile Glu Pro Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu 50 55 60 Thr Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Thr Asn Val Pro 65 70 75 80

Page 3391

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Gln Met Leu Ser Asn 85 Met Val Gly Lys Lys Thr Ile Pro Phe Ser Ser 90 95 Cys Ala Thr Gln Met Tyr Phe Ser Leu Ser Phe Gly Met Ile Glu Cys 100 105 110 Val Leu Leu Gly Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Gln Ser Val Cys Val Gln Leu 130 135 140 Ala Thr Ile Ser Trp Ser Ile Ser Phe Leu Ser Ser Met Val Ile Asn 145 150 155 160 Val Leu Thr Leu Ser Leu Pro Tyr Cys Gly Pro Asn Val Leu Asn His 165 170 175 Phe Phe Cys Glu Val Pro Ser Val Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 Ser Phe Thr Glu Leu Val Val Phe Ile Phe Ser Ile Ile Ile Val Phe 195 200 205 Ile Pro Phe Leu Leu Ile Val Val Ser Tyr Ala Arg Ile Leu Leu Ser 210 215 220 Val Leu Arg Ile Arg Ser Ala Ser Gly Arg His Lys Ala Leu Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ala Leu Phe Tyr Gly Thr Ala Ile 245 250 255 Phe Met Tyr Met Arg Pro Gln Ser Lys Ser Ser Arg Ala Gly Gly Lys 260 265 270 Ile Ile Ala Val Phe Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Leu 275 280 285

Page 3392

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Ile Tyr Ser Leu Arg Asn Gln Asp Val Lys Gly Ala Leu Arg Arg Ala 290 295 300

Ile Ala Lys Gln Lys Thr

305 310 <210> 3041 <211> 918 <212> DNA <213> Felis catus <400> 3041

atggagagaa gcaatcacac agcgacggag ttcatcctgg tgggtttcac cacagaccca 60 acgatgcagc tggtcctgtt tgtggtattc cttggtgtgt actctctgac tgtggttgga 120 aatacctccc tcatggtgtt gatctgtaaa gactcccggc tgcacacacc tatgtatttt 180 ttcattggga atctatcttt tctggatctc tggtattcca ctgtctacac cccaaagatc 240 ctcatgacct gcatctctga agacaaaagc atctcctttg ctggctgtgt atgtcagttc 300 ttcttctctg ctgggctggc atacagtgag tgttacctgt tggctgccat ggcttatgac 360 cgctacatgg ccatctcaaa gccattgctt tattctcagg ctatgtctgt aaagctatgt 420 gcatctttgg tagcttcttc ataccttggt ggctttatta actcttctat tatcaccaaa 480 agaacttttg ccttgaactt ctgtagtggc aatgtcattg atgacttttt ttgtgatttg 540 cttcccctgg tgaagttggc ttgtggcaaa aaagatggct accagactgt gctctatttc 600 ctcctggcct ccaatgtcat cacccccaca gtgctcatcc tcgcttccta cctgttcatc 660 attgccacca tcttgaggat ccgttccacc cagggccgcc tcaaagcttt ctccacctgt 720 tcctcccacc tgatctctgt caccttgtac tatggctcca ttctctacat ctattctcgt 780 ccccagtcta gctattcttt ggacagggac aaaatagttt ctacatttta cactgtggtg 840 ttccccatgt tgaaccccat gatctatagc ctgagaaata aggatgtaaa agaggctctg 900 gataaactca ttaaataa 918

<210> 3042 <211> 305 <212> PRT <213> Felis catus

Page 3393

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<400> 3042 Asn His Thr Ala Thr Glu Phe Ile Leu Val Gly 15 Phe Met 1 Glu Arg Ser 5 10 Thr Thr Asp Pro Thr Met Gln Leu Val Leu Phe Val Val Phe Leu Gly 20 25 30 Val Tyr Ser Leu Thr Val Val Gly Asn Thr Ser Leu Met Val Leu Ile 35 40 45 Cys Lys Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Ile Gly Asn 50 55 60 Leu Ser Phe Leu Asp Leu Trp Tyr Ser Thr Val Tyr Thr Pro Lys Ile 65 70 75 80 Leu Met Thr Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys 85 90 95 Val Cys Gln Phe Phe Phe Ser Ala Gly Leu Ala Tyr Ser Glu Cys Tyr 100 105 110 Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Met Ala Ile Ser Lys Pro 115 120 125 Leu Leu Tyr Ser Gln Ala Met Ser Val Lys Leu Cys Ala Ser Leu Val 130 135 140 Ala Ser Ser Tyr Leu Gly Gly Phe Ile Asn Ser Ser Ile Ile Thr Lys 145 150 155 160 Arg Thr Phe Ala Leu Asn Phe Cys Ser Gly Asn Val Ile Asp Asp Phe 165 170 175 Phe Cys Asp Leu Leu Pro Leu Val Lys Leu Ala Cys Gly Lys Lys Asp 180 185 190 Gly Tyr Gln Thr Val Leu Tyr Phe Leu Leu Ala Ser Asn Val Ile Thr 195 200 205

Page 3394

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Pro Thr 210 Val Leu Ile Leu Ala Ser Tyr Leu Phe Ile Ile Ala Thr Ile 215 220 Leu Arg Ile Arg Ser Thr Gln Gly Arg Leu Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Ile Ser Val Thr Leu Tyr Tyr Gly Ser Ile Leu Tyr 245 250 255 Ile Tyr Ser Arg Pro Gln Ser Ser Tyr Ser Leu Asp Arg Asp Lys Ile 260 265 270 Val Ser Thr Phe Tyr Thr Val Val Phe Pro Met Leu Asn Pro Met Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Asp Lys Leu Ile 290 295 300

Lys

305

<210> 3043 <211> 923 <212> DNA <213> Felis catus <400> 3043 atggaaagaa gcaatcatac agtgactgag ttcattctgg tgggtttcac cacagaccca 60 acgatgcagc tggtcctgtt tggggtattc cttggtgtgt actctctgac tgtggtaggg 120 aataccaccc tcatagtgtt gatctgtaac gactcccggc tgcacacacc catgtatttt 180 ttcattggga atctgtcttt tttggatctc tggtattcct ctgtctacac cccaaagatc 240 ctcatgacct gtatctctga agacaaaagc atctcctttg ctggctgtgt atctcagttc 300 ttcttctctg ctgggttggc atacagtgag tgttacctgt tggctgccat ggcttatgac 360 cgctacgcag ccatttccaa ccctctgctt tatgctcagt ccgtgtcaag gacattgtgc 420 atctgtttgg ttacatattc ctacactgga ggttttgtca atgcaataat actcaccagc 480

Page 3395

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aacacattca cattggattt ttgtggtgac aatgtcattg acgacttttt ctgtgatgtc 540 ccacctctgg tgaagttggc gtgtgatgtt aaagagagct accaggctgt gctctacttc 600 ctcctggcct ccaatgttat cacccccacg acgctcatcc tcgcctccta cctgttcatc 660 atcgctgcca tcttaagaat tcgctccgcc cagggccgcc gcaaggcctt ctccacctgc 720 tcctcccacc tggtctctgt caccttgtac tatggctcca ttctctacat ctattctcgc 780 ccaagttcca gctattccct tgagagggac aaaatggtgt ccacatttta tactgtgctc 840 ttccctatgt tgaaccccat gatctatagt ctgaggaata aggatgtgaa agaggctctg 900 aaaaaactct ttcggttaac aca 923

<210> 3044 <211> 308 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (308)..(308) <223> Any amino acid <400> 3044

Met Glu Arg Ser Asn His Thr Val Thr Glu Phe Ile Leu Val Gly Phe 1 5 10 15 Thr Thr Asp Pro Thr Met Gln Leu Val Leu Phe Gly Val Phe Leu Gly 20 25 30 Val Tyr Ser Leu Thr Val Val Gly Asn Thr Thr Leu Ile Val Leu Ile 35 40 45 Cys Asn Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Ile Gly Asn 50 55 60 Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val Tyr Thr Pro Lys Ile 65 70 75 80 Leu Met Thr Cys Ile Ser Glu Asp Lys Ser Ile Ser Phe Ala Gly Cys 85 90 95

Page 3396

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Val Ser Gln Phe 100 Phe Phe Ser Ala Gly Leu Ala Tyr Ser Glu Cys Tyr 105 110 Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Ser Asn Pro 115 120 125 Leu Leu Tyr Ala Gln Ser Val Ser Arg Thr Leu Cys Ile Cys Leu Val 130 135 140 Thr Tyr Ser Tyr Thr Gly Gly Phe Val Asn Ala Ile Ile Leu Thr Ser 145 150 155 160 Asn Thr Phe Thr Leu Asp Phe Cys Gly Asp Asn Val Ile Asp Asp Phe 165 170 175 Phe Cys Asp Val Pro Pro Leu Val Lys Leu Ala Cys Asp Val Lys Glu 180 185 190 Ser Tyr Gln Ala Val Leu Tyr Phe Leu Leu Ala Ser Asn Val Ile Thr 195 200 205 Pro Thr Thr Leu Ile Leu Ala Ser Tyr Leu Phe Ile Ile Ala Ala Ile 210 215 220 Leu Arg Ile Arg Ser Ala Gln Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Val Ser Val Thr Leu Tyr Tyr Gly Ser Ile Leu Tyr 245 250 255 Ile Tyr Ser Arg Pro Ser Ser Ser Tyr Ser Leu Glu Arg Asp Lys Met 260 265 270 Val Ser Thr Phe Tyr Thr Val Leu Phe Pro Met Leu Asn Pro Met Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Leu Lys Lys Leu Phe 290 295 300

Page 3397

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Arg Leu Thr Xaa

305 <210> 3045 <211> 938 <212> DNA <213> Felis catus <400> 3045

tcatctctgt ggccttatgg tttgtgctgc cttccagaag gcctctttga catctttgtt 60 tctcaggctg tagatgagag ggttgagcaa tgggttgacc acagtgtaga acagagcagc 120 tactttgtct ctttccaggg agtaggtaga acttggcctt gaatacatga agagcaagga 180 tccgtagaag aacatgactg agatgagatg tgaggcacag gtggagaagg ccttgcgcct 240 tcctgaggct gagtggatcc tcaggatcgc caggaggatg ttgaaatagg aaaccaagat 300 ggcaaggatg ctggagagga ctgtgaagcc caccacaccc aagaggactt tttcatagac 360 gtgggtatct gtacaagaca tttttaccaa tggtggcgca tcacagaaga agtggtctat 420 gatgttttta ccacagaagg tcaggcggaa agtgttggca gtatgggcta tggcgtttaa 480 aagtcctcct aagtaggagc cagcaacgag tccagtacag agagaattgg acatagtact 540 tgaataaagt agtgggttgc agattgcagc atgccggtca taggccatgg ctgctaggag 600 ataacactca gtataggcta caacacagga aaaaacaact gggcgccaca tccagccaag 660 gaaatacgtt tatcttctga gacacaatta gccaagattt tgggagtgta tacagaagtg 720 taccaaaaat ccaagaagga cagattgccg atgaaaaagt acatgggcgt gtgcaggcgg 780 gaatcaaccc ggattaggat gaccagggtc atattccccg acaaagtcat caaatagagt 840 atcagaaaaa ttccaaatag aatcagctgc caccgtgggt ctgctgagaa acccaccaag 900 atgaattcag tcagaagggt gcgatttcct acttccat 938

<210> 3046 <211> 216 <212> PRT <213> Felis catus <400> 3046

Met Trp Arg Pro Val Val Phe Ser Cys Val Val Ala Tyr Thr Glu Cys 1 5 10 15

Page 3398

069269_0225_SL.TXT

Tyr Leu Leu Ala 20 Ala Met Ala Tyr Asp Arg His Ala Ala Ile Cys Asn 25 30 Pro Leu Leu Tyr Ser Ser Thr Met Ser Asn Ser Leu Cys Thr Gly Leu 35 40 45 Val Ala Gly Ser Tyr Leu Gly Gly Leu Leu Asn Ala Ile Ala His Thr 50 55 60 Ala Asn Thr Phe Arg Leu Thr Phe Cys Gly Lys Asn Ile Ile Asp His 65 70 75 80 Phe Phe Cys Asp Ala Pro Pro Leu Val Lys Met Ser Cys Thr Asp Thr 85 90 95 His Val Tyr Glu Lys Val Leu Leu Gly Val Val Gly Phe Thr Val Leu 100 105 110 Ser Ser Ile Leu Ala Ile Leu Val Ser Tyr Phe Asn Ile Leu Leu Ala 115 120 125 Ile Leu Arg Ile His Ser Ala Ser Gly Arg Arg Lys Ala Phe Ser Thr 130 135 140 Cys Ala Ser His Leu Ile Ser Val Met Phe Phe Tyr Gly Ser Leu Leu 145 150 155 160 Phe Met Tyr Ser Arg Pro Ser Ser Thr Tyr Ser Leu Glu Arg Asp Lys 165 170 175 Val Ala Ala Leu Phe Tyr Thr Val Val Asn Pro Leu Leu Asn Pro Leu 180 185 190 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ala Phe Trp Lys Ala 195 200 205 Ala Gln Thr Ile Arg Pro Gln Arg 210 215

Page 3399

069269_0225_SL.TXT <210> 3047 <211> 936 <212> DNA <213> Felis catus <400> 3047

ttaagaaaat gttgccctat ctaacatttt cttcagggca tctttaacat ctttatttct 60 taagctataa atcaagggat tcaacattgg tatgaccaca gtatagaaga ctgaaaccac 120 tttatccctt tctagagcat agctggtact tggtcgggag taaacgaaga gaatagagcc 180 gtagtacaaa gtgacagccg tcaggtgaga gccacaagtg gagacggcct tgaggcggcc 240 ttgggtggag cgcatctttg agatggcagc agcaatgaag aggtaagagg caaggatgag 300 cacagtggga gtaatgacat tggaggccag tatgaaatag agcacagcct ggtagctctc 360 cttcacgtca caggccagct ttacaagggg aggtagatca caaaagtaat cgtcaatgac 420 attgttccca cagaagctca gggtaaatgt ctcactggta atgagggttg agttaagaaa 480 gccaccaaag tatgaaactg caacaagacc agtacataac ctcgaagaca ttgcctggaa 540 ataaagcaga ggattggaga tggccgtgta gcggtcgtaa gccatggcag ccaacaggta 600 acactcactg tatgccagcc cagccgagaa gaagaactga gcaaggcagc cagcaaagga 660 gatgcttttg tcttccgcag cgcaggtcat gaggatttgg ggggcataga cagaagagta 720 ccagagatcc aggaaggaaa gatttccaat gaagaaatac atgggtgtgt ggagttgaga 780 atcagcaccg atcagagaaa tcagggtgat gttcccggac agactgatga catagatggt 840 gaggaaaatg acaaagagta ctctctgtaa ccacaagtct gctgtgaacc ctagaagtat 900 aaactctttc actctggtga aatttttctc atccat 936

<210> 3048 <211> 311 <212> PRT <213> Felis catus <400> 3048

Met Asp Glu Lys Asn Phe Thr Arg Val Lys Glu Phe Ile Leu Leu Gly

1 5 10 15

Phe Thr Ala Asp Leu Trp Leu Gln Arg Val Leu Phe Val Ile Phe Leu

Page 3400

069269_0225_SL.TXT 25 30

Thr Ile Tyr 35 Val Ile Ser Leu Ser Gly Asn Ile Thr Leu Ile Ser Leu 40 45 Ile Gly Ala Asp Ser Gln Leu His Thr Pro Met Tyr Phe Phe Ile Gly 50 55 60 Asn Leu Ser Phe Leu Asp Leu Trp Tyr Ser Ser Val Tyr Ala Pro Gln 65 70 75 80 Ile Leu Met Thr Cys Ala Ala Glu Asp Lys Ser Ile Ser Phe Ala Gly 85 90 95 Cys Leu Ala Gln Phe Phe Phe Ser Ala Gly Leu Ala Tyr Ser Glu Cys 100 105 110 Tyr Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Thr Ala Ile Ser Asn 115 120 125 Pro Leu Leu Tyr Phe Gln Ala Met Ser Ser Arg Leu Cys Thr Gly Leu 130 135 140 Val Ala Val Ser Tyr Phe Gly Gly Phe Leu Asn Ser Thr Leu Ile Thr 145 150 155 160 Ser Glu Thr Phe Thr Leu Ser Phe Cys Gly Asn Asn Val Ile Asp Asp 165 170 175 Tyr Phe Cys Asp Leu Pro Pro Leu Val Lys Leu Ala Cys Asp Val Lys 180 185 190 Glu Ser Tyr Gln Ala Val Leu Tyr Phe Ile Leu Ala Ser Asn Val Ile 195 200 205 Thr Pro Thr Val Leu Ile Leu Ala Ser Tyr Leu Phe Ile Ala Ala Ala 210 215 220 Ile Ser Lys Met Arg Ser Thr Gln Gly Arg Leu Lys Ala Val Ser Thr

Page 3401

0 6926 9_02 25_S iL.TX T 225 230 235 240 Cys Gly Ser His Leu Thr Ala Val Thr Leu Tyr Tyr Gly Ser Ile Leu 245 250 255 Phe Val Tyr Ser Arg Pro Ser Thr Ser Tyr Ala Leu Glu Arg Asp Lys 260 265 270 Val Val Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Leu Lys Lys Met 290 295 300 Leu Asp Arg Ala Thr Phe Ser

305 310 <210> 3049 <211> 934 <212> DNA <213> Felis catus <400> 3049 ttaggccata caaaacttcc tcttagcagc agtcctgtgg atggcatctt tgacttcctt gttcctcaag ctgtagataa gtgggttcaa catggggatc actgcagtgt aaaacactga caccacttta ttgagatcca gagacagact tgctctaggt cgtacataaa taaagaaaag agtaccatac aggatggaga cgaccgtcag gtgagaagag caggtagaaa aggctttgcg cctcccatcc acagagtgga tcttcatgat ggcgacaagg atgtaaatgt aggaaatcag gatagtcaga ccgctgaaga ctccaacagc tccagctacg acaaaaacta ccaacttagt aagccttgtg tcagcacata caagggaaag gaggggggac atatcacaga agaaatgatt aatgacattg gggccacaaa aaggaagaag gaatgcattt gttgtatggg tcatggtgtt catgaacccg atgacatagg gaccaaccac cagctggata cagagtctct gggacatggc aacagaatac aataatgggt tgcagatggc cacatagcgg tcataggcca tggacgccaa gagaaaacac tctgctgcca caaagaaccc aaaaaaccac tgctgcaaag cacagcccaa gaaggagatg gccttcctct tcgcaaagac gtccgtgagc atcttggggc tcacaacaga Page 3402

120

180

240

300

360

420

480

540

600

660

720

069269_0225_SL.TXT ggagaagcac atgtccacaa aggacaagtg gctgaggaga aagtacatgg gtgtgtgaag gcgggaatca atccgaatca gaataatcat acccaagttt ccggttagat tgatgacgta gaaactcagg aagagcagga agagggaggc ctgcaattgg gggttgtcac tcaaacctgc caaaatgaac tctgtaaccc ttgtgtagtt gtca

780

840

900

934 <210> 3050 <211> 310 <212> PRT <213> Felis catus <400> 3050

Asp Asn Tyr Thr 1 Arg 5 Val Thr Glu Phe Ile Leu Ala Gly Leu Ser Asp 10 15 Asn Pro Gln Leu Gln Ala Ser Leu Phe Leu Leu Phe Leu Ser Phe Tyr 20 25 30 Val Ile Asn Leu Thr Gly Asn Leu Gly Met Ile Ile Leu Ile Arg Ile 35 40 45 Asp Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser His Leu Ser 50 55 60 Phe Val Asp Met Cys Phe Ser Ser Val Val Ser Pro Lys Met Leu Thr 65 70 75 80 Asp Val Phe Ala Lys Arg Lys Ala Ile Ser Phe Leu Gly Cys Ala Leu 85 90 95 Gln Gln Trp Phe Phe Gly Phe Phe Val Ala Ala Glu Cys Phe Leu Leu 100 105 110 Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Leu 115 120 125 Tyr Ser Val Ala Met Ser Gln Arg Leu Cys Ile Gln Leu Val Val Gly 130 135 140

Page 3403

Pro 145 Tyr Val Ile Gly Phe 150 Met 069269_0225_SL.TXT Asn Thr Met Thr His Thr 155 Thr Asn Ala 160 Phe Leu Leu Pro Phe Cys Gly Pro Asn Val Ile Asn His Phe Phe Cys 165 170 175 Asp Met Ser Pro Leu Leu Ser Leu Val Cys Ala Asp Thr Arg Leu Thr 180 185 190 Lys Leu Val Val Phe Val Val Ala Gly Ala Val Gly Val Phe Ser Gly 195 200 205 Leu Thr Ile Leu Ile Ser Tyr Ile Tyr Ile Leu Val Ala Ile Met Lys 210 215 220 Ile His Ser Val Asp Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser 225 230 235 240 His Leu Thr Val Val Ser Ile Leu Tyr Gly Thr Leu Phe Phe Ile Tyr 245 250 255 Val Arg Pro Arg Ala Ser Leu Ser Leu Asp Leu Asn Lys Val Val Ser 260 265 270 Val Phe Tyr Thr Ala Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser 275 280 285 Leu Arg Asn Lys Glu Val Lys Asp Ala Ile His Arg Thr Ala Ala Lys 290 295 300 Arg Lys Phe Cys Met Ala 305 310

<210> 3051 <211> 945 <212> DNA <213> Felis catus <400> 3051 ttaacttctt atgcaaaact tccccctgac gatcgttctg cacatggcag ctttcacttc

Page 3404

069269_0225_SL.TXT

tttatttctc aagctgtaga tgagaggatt caacatgggg atcactgctg tgtagaacac 120 cgacaccact ttattgatgt ccagagaaaa gattgcacct ggtcgcacat agataaagaa 180 gagggtccca tataagatgg acactgcggt gagatgggag gagcaggtgg aaaaggcttt 240 gcgcctccca tcgccagagc ggatcctcag gatggcagta aggatgtaaa aataggagat 300 tacaatggtc aggctactga caaccagtac agctccagcc acaatgaaaa ccaacagttt 360 attgatccgg gtgtcagcac ataccagaga aagaaggggg gacatgtcac aaaagaaatg 420 attgataatg ttggagcgac aaaagggaag tcggaaagca gccgttgtgt gagtcatggt 480 gctcatgaag ccaatagtat agggtccaac caccaactgt acgcagagtc tctgtgacat 540 ggagacagaa tacaataatg ggttacagat ggccacatag cggtcgtaag ccatggacgc 600 caggagaagg cactcaatgg ccacaaagaa cccaaagaac cattgctgca aggcacagcc 660 caggaaggag atggccttcc tctcagtgaa gaagtcagtg agcatcttgg gacccactac 720 tgatgaaaag cagatgtcca caaaagacag gtgactgaga aaaaagtaca tgggcgtgtg 780 aaggcgggga tctatctgga taagaataat catacccaag tttcctgtga tggtaacaag 840 gtaaaaaagt agaaatagca agaaaaggaa gacttgcatt cgaggatgat acttcaaact 900 tatgaaaata aattctgtga ttcttgtatt gttcccatca gccat 945

<210> 3052 <211> 314 <212> PRT <213> Felis catus <400> 3052

Met Ala Asp Gly Asn Asn Thr Arg Ile Thr Glu Phe Ile Phe Ile Ser 1 5 10 15 Leu Lys Tyr His Pro Arg Met Gln Val Phe Leu Phe Leu Leu Phe Leu 20 25 30 Leu Phe Tyr Leu Val Thr Ile Thr Gly Asn Leu Gly Met Ile Ile Leu 35 40 45 Ile Gln Ile Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60

Page 3405

069269_0225_SL.TXT

His 65 Leu Ser Phe Val Asp Ile Cys Phe Ser Ser Val Val Gly Pro Lys 70 75 80 Met Leu Thr Asp Phe Phe Thr Glu Arg Lys Ala Ile Ser Phe Leu Gly 85 90 95 Cys Ala Leu Gln Gln Trp Phe Phe Gly Phe Phe Val Ala Ile Glu Cys 100 105 110 Leu Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Ser Val Ser Met Ser Gln Arg Leu Cys Val Gln Leu 130 135 140 Val Val Gly Pro Tyr Thr Ile Gly Phe Met Ser Thr Met Thr His Thr 145 150 155 160 Thr Ala Ala Phe Arg Leu Pro Phe Cys Arg Ser Asn Ile Ile Asn His 165 170 175 Phe Phe Cys Asp Met Ser Pro Leu Leu Ser Leu Val Cys Ala Asp Thr 180 185 190 Arg Ile Asn Lys Leu Leu Val Phe Ile Val Ala Gly Ala Val Leu Val 195 200 205 Val Ser Ser Leu Thr Ile Val Ile Ser Tyr Phe Tyr Ile Leu Thr Ala 210 215 220 Ile Leu Arg Ile Arg Ser Gly Asp Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ser Ile Leu Tyr Gly Thr Leu Phe 245 250 255 Phe Ile Tyr Val Arg Pro Gly Ala Ile Phe Ser Leu Asp Ile Asn Lys 260 265 270

Page 3406

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Val Val Ser Val Phe Tyr Thr Ala Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Met Cys Arg Thr 290 295 300 Ile Val Arg Gly Lys Phe Cys Ile Arg Ser 305 310

<210> 3053 <211> 945 <212> DNA <213> Felis catus <400> 3053 atggaattta gaaatcaaac tttggtcact gagtttttat ttgtgggctt aacaaattac 60 ttccagcacc aggttgttct gtttgtgatg tttctcttgg cttatctggt cactcttctg 120 ggaaatgtgg ggatgatcac cctcatttgg atggattccc ggctccacac tcccatgtac 180 ttttttctca gccacttgtc ctttgtggat gtctgctcct cttctgtcat tggtcccaag 240 atgttgacag acatctttgt gaaaaaaaaa gtaatctctt tcttgggttg tgcttcccag 300 ttatggtttt ttggtcagtt tgtagtgaca gagtgtttcc tgttggcctc catggcttat 360 gacaggtata tggccatctg taagcccttg ttgtatacac tcattatgtc ccggcgaatc 420 tgtgtgcagc tggtggtagg gccttatacc atgggtctta taagcgccat aacgcatacg 480 acgtttgcct ttcgcctgcc ttactgtggt ccaaatacca tcaatcactt cttctgtgac 540 cttcttcctg ttctctccct ggcatgtgca gacacccagg tcaatcaggt tttacttttc 600 atcttggctg gagctctagg agtgctcagt ggtgtgatca tcctggtttc ctacatttac 660 atcgtggtca ctatcttgag gatccgctct gctgagggga ggcgcaaagc cttctccacc 720 tgctcttcac acctgactgc tgtctccatc ctgtatggga cactcttctt tatctacgta 780 cgccccagtt ctagtttctc gctggacatc aataaagtgg tttctgtgtt ctacacagcc 840 gtgatcccca tgttgaaccc ccttatctac agcctgagaa acagagaggt caaggattca 900 ttcagaagga cgtttgagaa gaagaatctt cttctgagta ggtaa 945

Page 3407

069269_0225_SL.TXT <210> 3054 <211> 314 <212> PRT <213> Felis catus

<400> 3054 Met 1 Glu Phe Arg Asn Gln Thr Leu 5 Val Thr 10 Glu Phe Leu Phe Val Gly 15 Leu Thr Asn Tyr Phe Gln His Gln Val Val Leu Phe Val Met Phe Leu 20 25 30 Leu Ala Tyr Leu Val Thr Leu Leu Gly Asn Val Gly Met Ile Thr Leu 35 40 45 Ile Trp Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Val Cys Ser Ser Ser Val Ile Gly Pro Lys 65 70 75 80 Met Leu Thr Asp Ile Phe Val Lys Lys Lys Val Ile Ser Phe Leu Gly 85 90 95 Cys Ala Ser Gln Leu Trp Phe Phe Gly Gln Phe Val Val Thr Glu Cys 100 105 110 Phe Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Thr Leu Ile Met Ser Arg Arg Ile Cys Val Gln Leu 130 135 140 Val Val Gly Pro Tyr Thr Met Gly Leu Ile Ser Ala Ile Thr His Thr 145 150 155 160 Thr Phe Ala Phe Arg Leu Pro Tyr Cys Gly Pro Asn Thr Ile Asn His 165 170 175 Phe Phe Cys Asp Leu Leu Pro Val Leu Ser Leu Ala Cys Ala Asp Thr 180 185 190

Page 3408

069269_0225_SL.TXT

Gln Val Asn Gln Val Leu Leu Phe Ile Leu Ala Gly Ala Leu Gly Val 195 200 205 Leu Ser Gly Val Ile Ile Leu Val Ser Tyr Ile Tyr Ile Val Val Thr 210 215 220 Ile Leu Arg Ile Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Ser Ile Leu Tyr Gly Thr Leu Phe 245 250 255 Phe Ile Tyr Val Arg Pro Ser Ser Ser Phe Ser Leu Asp Ile Asn Lys 260 265 270 Val Val Ser Val Phe Tyr Thr Ala Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Glu Val Lys Asp Ser Phe Arg Arg Thr 290 295 300 Phe Glu Lys Lys Asn Leu Leu Leu Ser Arg

305 310 <210> 3055 <211> 932 <212> DNA <213> Felis catus <400> 3055 ttacctactc agaagaagat tcttcttctc aaacgtcctt ctgaatgaat ccttgacctc tctgtttctc aggctgtaga taagggggtt caacatgggg atcacggctg tgtagaacac agaaaccact ttattgatgt ccagcgagaa actagaactg ggcgtacgta gataaagaag agtgtcccat acaggatgga gacagcagtc aggtgtgaag agcaggtgga gaaggctttg cgcctcccct cagcagagcg gatcctcaag atagtgacca cgatgtaaat gtaggaaacc aggatgatca caccactgag cactcctaga gctccagcca agatgaaaag taaaacctga

120

180

240

300

360

Page 3409

069269_0225_SL.TXT

ttgacctggg tgtctgcaca tgccagggag agaacaggaa gaaggtcaca gaagaagtga 420 ttgatggtat ttggaccaca gtaaggcagg cgaaaggtga acgtcgtgtg gatcatggtg 480 ctcataagac ccatggtata aggccctacc accagctgca tgcagattcg ccgggacata 540 atgagtgtat acaacaaggg cttacagatg gccatatacc tgtcataagc catggaggcc 600 aacaggaaac actctgtcac tacaaactga ccaaaaaacc agatctgggc agcacaaccc 660 aagaaagaga ttactttttt tttcacaaag atgtctgtca acatcttggg accaatgaca 720 gaagaggagc agacatccac aaaggacaag tggctgagaa aaaagtacat gggagtgtgg 780 agccgggaat ccatccaaat gagggtgatc atccccacat ttcccagaag agtgaccaga 840 taagccaaga gaaacatcac aaacagaaca acctggtgct ggaagtaatt tgttaagccc 900 acaaataaaa actcagtgac caaagtttga tt 932 <210> 3056 <211> 276 <212> PRT <213> Felis catus <400> 3056 Asn Gln Thr Leu Val Thr Glu Phe Leu Phe Val Gly Leu Thr Asn Tyr 1 5 10 15 Phe Gln His Gln Val Val Leu Phe Val Met Phe Leu Leu Ala Tyr Leu 20 25 30 Val Thr Leu Leu Gly Asn Val Gly Met Ile Thr Leu Ile Trp Met Asp 35 40 45 Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His Leu Ser Phe 50 55 60 Val Asp Val Cys Ser Ser Ser Val Ile Gly Pro Lys Met Leu Thr Asp 65 70 75 80 Ile Phe Val Lys Lys Lys Val Ile Ser Phe Leu Gly Cys Ala Ala Gln 85 90 95 Ile Trp Phe Phe Gly Gln Phe Val Val Thr Glu Cys Phe Leu Leu Ala

Page 3410

100

069269_0225_SL.TXT 105 110

Ser Met Ala Tyr Asp Arg Tyr Met 120 Ala Ile Cys Lys Pro 125 Leu Leu Tyr 115 Thr Leu Ile Met Ser Arg Arg Ile Cys Met Gln Leu Val Val Gly Pro 130 135 140 Tyr Thr Met Gly Leu Met Ser Thr Met Ile His Thr Thr Phe Thr Phe 145 150 155 160 Arg Leu Pro Tyr Cys Gly Pro Asn Thr Ile Asn His Phe Phe Cys Asp 165 170 175 Leu Leu Pro Val Leu Ser Leu Ala Cys Ala Asp Thr Gln Val Asn Gln 180 185 190 Val Leu Leu Phe Ile Leu Ala Gly Ala Leu Gly Val Leu Ser Gly Val 195 200 205 Ile Ile Leu Val Ser Tyr Ile Tyr Ile Val Val Thr Ile Leu Arg Ile 210 215 220 Arg Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys Ser Ser His 225 230 235 240 Leu Thr Ala Val Ser Ile Leu Tyr Gly Thr Leu Phe Phe Ile Tyr Val 245 250 255 Arg Pro Val Leu Val Ser Arg Trp Thr Ser Ile Lys Trp Phe Leu Cys 260 265 270

Ser Thr Gln Pro 275 <210> 3057 <211> 930 <212> DNA <213> Felis catus

Page 3411

069269_0225_SL.TXT <400> 3057 atgacaaaag aaaatatcac taaagtgact gaattttttc ttctggggtt tggtgcccaa 60 aacaagtttc gagacctcct cttcattgta tttctggtca tctatgcgac ttccatggtg 120 ggtaatattg gaatgatcct actcatcaag acagattcca gacttcaaac acccatgtac 180 tttttcctac aacatttggc ttttgttgat atctgttata cctccgctat cactcccaag 240 atgctgcaaa acttcatatt agaaaacaaa tctatatcct ttgagggctg tataatgcaa 300 ttattggttt atgcaacatt tgcaaccagt gactgttacc tcctggctgc tatggcagtg 360 gatcgttatg tagccatctg taacccactt cactacccca taatcatgtc ccgaagagtc 420 tgcatccaac tggtagctgg ttcatatgtc atgggttcaa taaatgcttc cgtgcacaca 480 ggttttacat tttcactgtc cttctgcaaa tccaatacca tcaatcattt tttctgtgat 540 gttcccccaa ttcttgccct ttcatgctcc aacattgaca tcaacatcat gctccttgtt 600 gtctttgtgg gatttaactt gatattcact gtgtcagttg tcatcttttc ctacatgtat 660 atcatggccg ccatcctgaa gataccttct gtttcaggga ggaaaaaagc tttctccaca 720 tgtgcctccc acctgacagc agtcactgtt ttctatgcaa ccctgtcata catgtactta 780 cagccccaag ctagtaattc ccaggagaat atgaaagtag cctctgtatt ttatggcatt 840 gtgattcctc ttttgaaccc catgatctat agtttgagaa ataaggaagt gaaagaggct 900 ataaaaggga tgaggaaaaa gttcttctag 930 <210> 3058 <211> 309 <212> PRT <213> Felis catus <400> 3058

Met 1 Thr Lys Glu Asn Ile Thr Lys Val Thr Glu Phe Phe Leu Leu Gly 5 10 15 Phe Gly Ala Gln Asn Lys Phe Arg Asp Leu Leu Phe Ile Val Phe Leu 20 25 30 Val Ile Tyr Ala Thr Ser Met Val Gly Asn Ile Gly Met Ile Leu Leu 35 40 45

Page 3412

Ile Lys 50 Thr Asp Ser Arg Leu 55 069269_0225_SL.TXT Gln Thr Pro Met Tyr Phe 60 Phe Leu Gln His Leu Ala Phe Val Asp Ile Cys Tyr Thr Ser Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Gln Asn Phe Ile Leu Glu Asn Lys Ser Ile Ser Phe Glu Gly 85 90 95 Cys Ile Met Gln Leu Leu Val Tyr Ala Thr Phe Ala Thr Ser Asp Cys 100 105 110 Tyr Leu Leu Ala Ala Met Ala Val Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu His Tyr Pro Ile Ile Met Ser Arg Arg Val Cys Ile Gln Leu 130 135 140 Val Ala Gly Ser Tyr Val Met Gly Ser Ile Asn Ala Ser Val His Thr 145 150 155 160 Gly Phe Thr Phe Ser Leu Ser Phe Cys Lys Ser Asn Thr Ile Asn His 165 170 175 Phe Phe Cys Asp Val Pro Pro Ile Leu Ala Leu Ser Cys Ser Asn Ile 180 185 190 Asp Ile Asn Ile Met Leu Leu Val Val Phe Val Gly Phe Asn Leu Ile 195 200 205 Phe Thr Val Ser Val Val Ile Phe Ser Tyr Met Tyr Ile Met Ala Ala 210 215 220 Ile Leu Lys Ile Pro Ser Val Ser Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Val Thr Val Phe Tyr Ala Thr Leu Ser 245 250 255

Page 3413

069269_0225_SL.TXT

Tyr Met Tyr Leu Gln Pro Gln Ala Ser Asn Ser Gln Glu Asn Met Lys 260 265 270 Val Ala Ser Val Phe Tyr Gly Ile Val Ile Pro Leu Leu Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Ile Lys Gly Met 290 295 300 Arg Lys Lys Phe Phe

305 <210> 3059 <211> 928 <212> DNA <213> Felis catus <400> 3059

atggaacaaa acaatggcac tgaaataagt gagttcattc tcctgggatt tgctggtcaa 60 cgcaagtcgt ggcatattct cttcatagta tttctagtga tctacgtggc catcctagtg 120 ggcaatattg gaatgatcct actcatcaag attgattctt gccttcgtac cccgatgtat 180 tttttcctcc aacatttggc atttgttgat ctctgctaca cctctgctat cactcccaaa 240 atgctgcaaa actttgtaca aacagagcaa tccatctcat tcatagggtg tatggtgcaa 300 ttactagtct atggtgcttt tgcaacgact gactgttaca tcttggctgc aatggcagtg 360 gaccggtatg tcgccatctg caatccactc cgctatccaa tagtcatgtc ccagagagtc 420 tgcattcaac tcctatttgg ctcatacttc ataggttttc taaatgcctc tgtaaacaca 480 agttttactt tttcactgag cttttgcaaa tccaataaaa ttaaccactt tttctgtgat 540 gaacccccaa ttttagctct ctcttgctcc aacattgact tcaacatcat gctactaact 600 gtctttgtgg ggtttaacct aatgttcact gtgctggttg tcatcttttc ctacatatat 660 atcctggctg ccatcctgaa gatatcttcc attgcaggga agaaaaaagc cttctccacg 720 tgtgcctccc acctgacagc agtcactgtt ttctatggga ctctgtctta catgtatctg 780 caccatggga ccaatgagtc tcaagagcaa gaaaaaatgg cttctgtgtt ttatggcatt 840 atgatcccca tgttaaaccc cctcatctac agcctgagaa accaagatgt gaaggaagcc 900

Page 3414

069269_0225_SL.TXT ctaaaagtgg ttacaaagaa gtgcttct

928 <210> 3060 <211> 310 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (310)..(310) <223> Any amino acid

<400> 3060 Met Glu Gln 1 Asn Asn Gly Thr Glu Ile Ser Glu Phe Ile Leu Leu 15 Gly 5 10 Phe Ala Gly Gln Arg Lys Ser Trp His Ile Leu Phe Ile Val Phe Leu 20 25 30 Val Ile Tyr Val Ala Ile Leu Val Gly Asn Ile Gly Met Ile Leu Leu 35 40 45 Ile Lys Ile Asp Ser Cys Leu Arg Thr Pro Met Tyr Phe Phe Leu Gln 50 55 60 His Leu Ala Phe Val Asp Leu Cys Tyr Thr Ser Ala Ile Thr Pro Lys 65 70 75 80 Met Leu Gln Asn Phe Val Gln Thr Glu Gln Ser Ile Ser Phe Ile Gly 85 90 95 Cys Met Val Gln Leu Leu Val Tyr Gly Ala Phe Ala Thr Thr Asp Cys 100 105 110 Tyr Ile Leu Ala Ala Met Ala Val Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Ile Val Met Ser Gln Arg Val Cys Ile Gln Leu 130 135 140 Leu Phe Gly Ser Tyr Phe Ile Gly Phe Leu Asn Ala Ser Val Asn Thr

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145 150 Lys 170 155 Ser Asn 160 Ser Phe Thr Phe Ser 165 Leu Ser Phe Cys Lys Ile Asn His 175 Phe Phe Cys Asp Glu Pro Pro Ile Leu Ala Leu Ser Cys Ser Asn Ile 180 185 190 Asp Phe Asn Ile Met Leu Leu Thr Val Phe Val Gly Phe Asn Leu Met 195 200 205 Phe Thr Val Leu Val Val Ile Phe Ser Tyr Ile Tyr Ile Leu Ala Ala 210 215 220 Ile Leu Lys Ile Ser Ser Ile Ala Gly Lys Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Val Thr Val Phe Tyr Gly Thr Leu Ser 245 250 255 Tyr Met Tyr Leu His His Gly Thr Asn Glu Ser Gln Glu Gln Glu Lys 260 265 270 Met Ala Ser Val Phe Tyr Gly Ile Met Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Asp Val Lys Glu Ala Leu Lys Val Val 290 295 300 Thr Lys Lys Cys Phe Xaa 305 310 <210> 3061 <211> 957 <212> DNA <213> Felis catus <400> 3061 gcagggaaag ataccgacct ggagtttcct ctccagtgcg tcctttacct i ccttgttgcg gaggctatag atgaaggggt tgagcatggg aattatgatg gtgtagaaca cggacactat

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069269_0225_SL.TXT ttggccgttg gtatcattag aggatccgtg aggctggacg taggtgaaaa ccacagtgcc atagaaaatg gcaatggcca agaagtggga ggcacaggtg gagagggcct tctcccgtcc agctgctgag cgcatcctcc caatggccac caggaccaag ctgtaggagg tgaggatgac tgcagcaggc agaagggtaa ccagagcaga gaagatacag aggagcagcc ctgctgtggc cgtgttgcca cgagccaggc ggagaagggg tgggatgtca cagaagtagt gtgtcacctg gttgggccca cagaaaggca gagcaaagac attcccagtc tggatggcag agttggcacc accaaatgca taggaagcag ctaccagctg gacgcaggtc tccttagtca tgacagaacc gtaatggagg ggttggcaga tggccacaaa gcggtcaaag gccatggagg ccagcaggaa gctctcagct gtcacgtgca ccacaaagaa ggtcagttgg accacacagc cctcgaaaga gatggtctta tcggaggcca ggaagttgac caagagcttg ggtgtgacca cagatgagta acaaatatct agaaacgaca ggacactgag gaagaaatac atggggctat ggagacggga gtctgtgaag atgagtgcca tcattcccag gttgcccagc actgttatgg cataaatgag caggaaggct acaaacagaa gctcctggag atccgcataa ctggagaatc ccaacaagat gaactcggta actggagtgc ggttgccatt tgcaagggct agttctccag gtgtcat <210> 3062 <211> 319 <212> PRT <213> Felis catus

180

240

300

360

420

480

540

600

660

720

780

840

900

957

<400> 3062 Leu Ala Leu Ala Asn Gly Asn Arg Thr Pro Val Met 1 Thr Pro Gly Glu 5 10 15 Thr Glu Phe Ile Leu Leu Gly Phe Ser Ser Tyr Ala Asp Leu Gln Glu 20 25 30 Leu Leu Phe Val Ala Phe Leu Leu Ile Tyr Ala Ile Thr Val Leu Gly 35 40 45 Asn Leu Gly Met Met Ala Leu Ile Phe Thr Asp Ser Arg Leu His Ser 50 55 60

Page 3417

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Pro 65 Met Tyr Phe Phe Leu 70 Ser Val Leu Ser Phe Leu Asp Ile Cys Tyr 75 80 Ser Ser Val Val Thr Pro Lys Leu Leu Val Asn Phe Leu Ala Ser Asp 85 90 95 Lys Thr Ile Ser Phe Glu Gly Cys Val Val Gln Leu Thr Phe Phe Val 100 105 110 Val His Val Thr Ala Glu Ser Phe Leu Leu Ala Ser Met Ala Phe Asp 115 120 125 Arg Phe Val Ala Ile Cys Gln Pro Leu His Tyr Gly Ser Val Met Thr 130 135 140 Lys Glu Thr Cys Val Gln Leu Val Ala Ala Ser Tyr Ala Phe Gly Gly 145 150 155 160 Ala Asn Ser Ala Ile Gln Thr Gly Asn Val Phe Ala Leu Pro Phe Cys 165 170 175 Gly Pro Asn Gln Val Thr His Tyr Phe Cys Asp Ile Pro Pro Leu Leu 180 185 190 Arg Leu Ala Arg Gly Asn Thr Ala Thr Ala Gly Leu Leu Leu Cys Ile 195 200 205 Phe Ser Ala Leu Val Thr Leu Leu Pro Ala Ala Val Ile Leu Thr Ser 210 215 220 Tyr Ser Leu Val Leu Val Ala Ile Gly Arg Met Arg Ser Ala Ala Gly 225 230 235 240 Arg Glu Lys Ala Leu Ser Thr Cys Ala Ser His Phe Leu Ala Ile Ala 245 250 255 Ile Phe Tyr Gly Thr Val Val Phe Thr Tyr Val Gln Pro His Gly Ser 260 265 270

Page 3418

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Ser Asn Asp Thr Asn Gly Gln Ile Val Ser Val Phe Tyr Thr Ile Ile 275 280 285 Ile Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Glu Val 290 295 300 Lys Asp Ala Leu Glu Arg Lys Leu Gln Val Gly Ile Phe Pro Cys

305 310 315 <210> 3063 <211> 873 <212> DNA <213> Felis catus <400> 3063 ttccttaagc tgtagaccag ggggttcagc atggggatca caatggtgta gaacacagag 60 aggcccttgt tataggctgc agcacttcca gggttgggtt ggacatagac aaagaacaca 120 gacccgtaga agagggagag gcagtgaggt gggaggcaca agtggagaaa gctttgtgct 180 gggcctccag ggacctcatc ctacagattg tgaccaggat gaaggcataa gagatcaaga 240 cggctgagac catggggaca gtgacccagg cagagaggca aagcaggatg acgttggcca 300 ctgtggtgtc tgagcaggcc agttggagca cagggaggat gtcacagaag aaacgatcaa 360 tgacgttggg accacagtag ggcaagatga aggcattcct tgtctgcgga gctgaaacga 420 acactcccgc agcgtaggtg accattacca gctggatgca caaacgctta gacatgatgg 480 cgtggtagag gagagggtgg cagatggcca caaatcgatc ataggccatt atggccaaga 540 gcaggctccc ctgtgccgtg gaggatcacg gaggccatct ggaccacaca gcctgtaaac 600 gagatggacc ggtccgtggt gaggatgctg atcagcagcc cgggggtgaa cacggaggaa 660 ttgcaggtgt ccaggaagga gagcacgctc agaagaaagt acatgggggt gtggaggacg 720 gagctggcac ggatcaggtc tatcatgccc aggttgcccg ccagtgtcac ggtgcagatc 780 atcaggaaga cggcaaagag gagttgtttt tggtctgcct ggtctgtgag gcccagcagg 840 atgaatcttg tcactgcggt gtgattctgc ccc 873 <210> 3064 <211> 117 <212> PRT

Page 3419

069269_0225_SL.TXT <213> Felis catus

<400> 3064 Gly Gln Asn His Thr Ala Val Thr 1 5 Asp Gln Ala Asp 20 Gln Lys Gln Leu Cys Thr Val 35 Thr Leu Ala Gly Asn 40 Ala Ser 50 Ser Val Leu His Thr 55 Pro Ser 65 Phe Leu Asp Thr Cys 70 Asn Ser Ile Ser Ile Leu Thr 85 Thr Asp Arg Val Gln Met Ala 100 Ser Val Ile Leu Gly His Asn Gly Leu

115

Arg Phe 10 Ile Leu Leu Gly Leu 15 Thr Leu 25 Phe Ala Val Phe Leu 30 Met Ile Leu Gly Met Ile Asp 45 Leu Ile Arg Met Tyr Phe Leu 60 Leu Ser Val Leu Ser Val Phe 75 Thr Pro Gly Leu Leu 80 Ser Ile 90 Ser Phe Thr Gly Cys 95 Val His 105 Gly Thr Gly Glu Pro 110 Ala Leu

<210> 3065 <211> 951 <212> DNA <213> Felis catus <400> 3065 atgcagccat atgccccaaa ctggacccac ggggtgcatg aagcacgccc cctcttcttt ctggtggaga acttggccat catcgtggtg atgtatttct tcctgacgca cttgtcctgc cccaagatgc tggctggttt tattggggta tgcctgtccc agctcttcat ctttaccttc gtaacagagt ttgtcatagt gggctttgct acactcttcc tcaccatgta cctattcacc gtggctttag accaccggct acgtagaccc cttgaaatct ggtacacttc ggtgacagtg ggtgggggca agaacatctc ctatgctggc ctgggggcaa cagagtgttt cctactggct Page 3420

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300

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069269_0225_SL.TXT

gccatggcct atgaccgcta tgtggccatt tgtatgcctc tccgatatgc ggccttggtg 420 tcgtggggcg cctgcatccg tctggccgct gcttgttggc tggcaggcct cctcacacct 480 gttttgccta tctacctcat gtcccagctg acgttttgtg gccccaacgt catcgaccac 540 ttcttctgtg atgcctcacc gctgctagcc ttgtcctgct cagatgtcac cctgaaggag 600 accacagact tcctcgtttc tctggcggtg ctcctggcct cctctacggt tatttctgtg 660 tcctatggca atatcgtctg gacgttgctg cacatccatt cagctgctga gcgcaggaag 720 gccttctcca cttgtgcagc tcacctgaca gtggtgagcc tcttctatgg cactcttttt 780 ttcatgtatg tccgcaccaa agtggcctcc tccgtcaact tcaacaaggt ggtgtctgtc 840 ttctactcca ttgtcacgcc aatgctcaac cccctcatct atagtcttcg gaacagggag 900 gtgaagggag ctctgggccg agccttgtcc ctcaggtctt ggaaaggtca ^g 951

<210> 3066 <211> 317 <212> PRT <213> Felis catus <400> 3066

Met Gln Pro Tyr Ala Pro Asn Trp Thr His Val Thr Glu Phe Val Ile 1 5 10 15 Val Gly Phe Ala Gly Val His Glu Ala Arg Pro Leu Phe Phe Thr Leu 20 25 30 Phe Leu Thr Met Tyr Leu Phe Thr Leu Val Glu Asn Leu Ala Ile Ile 35 40 45 Val Val Val Ala Leu Asp His Arg Leu Arg Arg Pro Met Tyr Phe Phe 50 55 60 Leu Thr His Leu Ser Cys Leu Glu Ile Trp Tyr Thr Ser Val Thr Val 65 70 75 80 Pro Lys Met Leu Ala Gly Phe Ile Gly Val Gly Gly Gly Lys Asn Ile 85 90 95

Page 3421

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Ser Tyr Ala Gly Cys Leu Ser Gln Leu Phe Ile Phe Thr Phe Leu Gly 100 105 110 Ala Thr Glu Cys Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys Met Pro Leu Arg Tyr Ala Ala Leu Val Ser Trp Gly Ala 130 135 140 Cys Ile Arg Leu Ala Ala Ala Cys Trp Leu Ala Gly Leu Leu Thr Pro 145 150 155 160 Val Leu Pro Ile Tyr Leu Met Ser Gln Leu Thr Phe Cys Gly Pro Asn 165 170 175 Val Ile Asp His Phe Phe Cys Asp Ala Ser Pro Leu Leu Ala Leu Ser 180 185 190 Cys Ser Asp Val Thr Leu Lys Glu Thr Thr Asp Phe Leu Val Ser Leu 195 200 205 Ala Val Leu Leu Ala Ser Ser Thr Val Ile Ser Val Ser Tyr Gly Asn 210 215 220 Ile Val Trp Thr Leu Leu His Ile His Ser Ala Ala Glu Arg Arg Lys 225 230 235 240 Ala Phe Ser Thr Cys Ala Ala His Leu Thr Val Val Ser Leu Phe Tyr 245 250 255 Gly Thr Leu Phe Phe Met Tyr Val Arg Thr Lys Val Ala Ser Ser Val 260 265 270 Asn Phe Asn Lys Val Val Ser Val Phe Tyr Ser Ile Val Thr Pro Met 275 280 285 Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Arg Glu Val Lys Gly Ala 290 295 300

Page 3422

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Leu Gly Arg Ala Leu Ser Leu Arg Ser Trp Lys Gly Gln 305 310 315 <210> 3067 <211> 888 <212> DNA <213> Felis catus <400> 3067 ttttctgaat gtgcagcttt tacacctttg ttcctcagac tgtagatcaa ggggttcggc 60 atgaggatga ccacggtgta aaagacagac acgatcttgt cctcctctgg gaatgagtct 120 gagtgatttc tctggtacac gaaggcaagc gtcctgaaga agaggacaac cgtggtgagg 180 cgggacatgc aggtggagaa ggtcttggct cgtccaccaa cagacttcac ccttgaaatg 240 gctctgatta tgagcctata ggagaccggg atgatcagga cattggccag gaacatgagc 300 ttggcaaaaa agaggatgac agtggcactt tgtgtcatgc ttggcaggca agcttcagca 360 ggggtgggag gtcacagaag aagtctgtca cagacagaga cggtcacaga aagagaaggt 420 gagggtgcat gtggtacgca ggatggcccc tgagacccca cagacatagg ctgcagccaa 480 caatccccag caggtgcctg gagtcatagc gaggttatag cacaatgggt tgctaacggc 540 aacaaagtgg ccataggcca tcaaacaccc tgtgcctgca cagagggtga agaaaaagaa 600 gtgggtagca cattggtcat aggagaggac cgtcttgcct gtggccagtg tggccaggat 660 ccaaggggtg atgaccgagg cgtcgcaggc atccagtagg gcgaggtggc tcaagaagaa 720 gtacatgggc ctgtggagtt ggacaccctc ttgggtcaga atgatcatcc ccacattccc 780 cagaagggtg acgacataga aaatgagaaa catcaggaag aggggccccg ccagttcagg 840 gtgatctgtg aaggccacaa gaatgaactc tgtcacagca gtgagatt 888 <210> 3068 <211> 166 <212> PRT <213> Felis catus

<400> 3068 Asn Leu Thr Ala Val Thr Glu Phe Ile Leu Val Ala Phe Thr Asp His 1 5 10 15 Pro Glu Leu Ala Gly Pro Leu Phe Leu Met Phe Leu Ile Phe Tyr Val 1 Page 3423

069269_0225_SL.TXT 25 30

Val Thr Leu Leu Gly Asn Val Gly Met Ile Ile Leu Thr Gln Glu Gly 35 40 45 Val Gln Leu His Arg Pro Met Tyr Phe Phe Leu Ser His Leu Ala Leu 50 55 60 Leu Asp Ala Cys Asp Ala Ser Val Ile Thr Pro Trp Ile Leu Ala Thr 65 70 75 80 Leu Ala Thr Gly Lys Thr Val Leu Ser Tyr Asp Gln Cys Ala Thr His 85 90 95 Phe Phe Phe Phe Thr Leu Cys Ala Gly Thr Gly Cys Leu Met Ala Tyr 100 105 110 Gly His Phe Val Ala Val Ser Asn Pro Leu Cys Tyr Asn Leu Ala Met 115 120 125 Thr Pro Gly Thr Cys Trp Gly Leu Leu Ala Ala Ala Tyr Val Cys Gly 130 135 140 Val Ser Gly Ala Ile Leu Arg Thr Thr Cys Thr Leu Thr Phe Ser Phe 145 150 155 160 Cys Asp Arg Leu Cys Leu

165 <210> 3069 <211> 934 <212> DNA <213> Felis <400> 3069 cacactcagg gtttcttagg cacgaccttg ggtcccaaag catus gacacctgga ctgtagatca tcttcctcca aaaagggcca gtctaccagt gagggtttag gggacttgcc cagcggtgag gacctttctg catggggatg cgagccactc gtgggaggca aaggctgctt accacagtgt cgcagataca catgtggaga tcacatcctt agaagacaga tgaagatgag aagtcttggc

120

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Page 3424

069269_0225_SL.TXT cttgccacgt ggagacttca ccttcagaat aatgaccaac gcgttggcca agatcacaaa gtttgttgtg tcattgcagg cgagcttcag gatctgattg tggtcacaga aggagagggt taacatccca cagacatagg cttccaccgc tacagtgtag agcagtgggt tgctaacagc caggaaacac tctgtgcctg cacagaaggt ataggagatg accgtcgtgc ctgtggccag ggcgtagcag gcatccagca gggcgaggtg ttggtcatcc acttggatca gaatgatcat gaaaatgaga aacgtcagga agaggggaat gagaatgaac tctgttaccg tagtaagatt <210> 3070 <211> 311 <212> PRT <213> Felis catus ggccttgatg atgagcaggt aggatatcag gttcccgaag aagacaatga caatctcagt caggggcggg aggtcacaga agaagaagtt gaaggtgcat gtggtacgca caatgaaccc caaactccag caaattctag gattcatggc aacatagcgg tcataggcca tcactgccag gaagaaaaag aactgggtac cacactggcc tgtggccagg atctgaggag tgatgaccga gctcaggaag aagtacatgg gcgtgtggag ccccatattc cccagaaggg tgacgatata ctccaacatg tggtagtcag taaagcccac attc

300

360

420

480

540

600

660

720

780

840

900

934

<400> 3070 Thr Val Thr 5 Glu Asn Asn 1 Leu Thr Tyr His Met Leu 20 Glu Ile Pro Leu Ile Val Thr 35 Leu Leu Gly Asn Met 40 Asp Asp 50 Gln Leu His Thr Pro 55 Met Leu 65 Leu Asp Ala Cys Tyr 70 Ala Ser

Phe Ile 10 Leu Val Gly Phe Thr 15 Asp Phe 25 Leu Thr Phe Leu Ile 30 Phe Tyr Gly Met Ile Ile Leu 45 Ile Gln Val Tyr Phe Phe Leu 60 Ser His Leu Ala Val Ile Thr 75 Pro Gln Ile Leu Ala 80

Page 3425

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Thr Leu Ala Thr Gly 85 Thr Thr Val Ile Ser Tyr Gly Gln Cys Gly Thr 90 95 Gln Phe Phe Phe Phe Thr Phe Cys Ala Gly Thr Glu Cys Phe Leu Leu 100 105 110 Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Val Ser Asn Pro Leu Leu 115 120 125 Tyr Thr Val Ala Met Asn Pro Arg Ile Cys Trp Ser Leu Ala Val Glu 130 135 140 Ala Tyr Val Cys Gly Met Leu Gly Phe Ile Val Arg Thr Thr Cys Thr 145 150 155 160 Phe Thr Leu Ser Phe Cys Asp His Asn Gln Ile Asn Phe Phe Phe Cys 165 170 175 Asp Leu Pro Pro Leu Leu Lys Leu Ala Cys Asn Asp Thr Thr Asn Thr 180 185 190 Glu Ile Val Ile Val Phe Phe Gly Asn Phe Val Ile Leu Ala Asn Ala 195 200 205 Leu Val Ile Leu Ile Ser Tyr Leu Leu Ile Ile Lys Ala Ile Leu Lys 210 215 220 Val Lys Ser Pro Arg Gly Lys Ala Lys Thr Phe Ser Thr Cys Ala Ser 225 230 235 240 His Leu Thr Ala Val Ala Leu Phe Phe Gly Thr Leu Ile Phe Met Tyr 245 250 255 Leu Arg Ser Gly Ser Gly Lys Ser Leu Glu Glu Asp Lys Val Val Ser 260 265 270 Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser 275 280 285

Page 3426

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Leu Arg Asn Lys Asp Val Lys Ala Ala Phe Arg Lys Val Thr Gly Arg 290 295 300

Leu Gln Val Ser Leu Ser Val 305 310 <210> 3071 <211> 934 <212> DNA <213> Felis catus <400> 3071 atggcagaga atgacactgt ggtgacagaa ttcattctaa tggcattcca gctgtcggca 60 gggctgcaaa tgagtctctt ctttgtgttt ctggtgctat atttcgtcac cgtggggggc 120 aacctgggca tgatagtgtt gattcagaga gaccttcgtc tccaaactcc catgtacttc 180 ttcctccgcc acctttcctt cctggacatt tgctactctt ctgtcattgt ccctcagttg 240 cttgagacct tgggtacccg taagatggcc atcacttacg aacgctgtgc cacccagttc 300 ttcttcttta cactctgtgc cagcaccgaa tgtttccttt tggctgtgat ggcctatgac 360 cgctatatgg ctgtgtgtaa ccccctcttc tacgccactg ccatgacacc acagacctgc 420 ctagggctgg tggctggggc atatgcttgt gccatggtca tcgctgtgat ccgcactggg 480 tgtacctttt cgatctcctt ctgtaagtcc aaccacgtgg acttcttttt ttgtgacctc 540 ccacccctgc tgaagcttgc gtgtagtgag accaagccac gggaacgggt catctacctc 600 ctagctttct tggtcattac gaccagcata tcagtgattc ttatatccta cttttttatc 660 attcatgcta ttctgaagat tcgtacagca ggtggcaaag tcaagacttt ctccacctgt 720 gtttctcaca tgactgcagt ggctcttttc tttgggacac tcatattcat atacctgaaa 780 ggtaacatgg gcgcatcgct tggggaggat aagattgtgt cagtatttta cacggtggtc 840 atccctatgc tgaacccaat gatctacagc ttgagaaaca aggaagtgaa ggaggctctg 900 aagaaaactc tcaacaggat aaaggtttcc caag 934 <210> 3072 <211> 312 <212> PRT <213> Felis catus

Page 3427

069269_0225_SL.TXT <220>

<221> MOD_RES <222> (312)..(312) <223> Any amino acid

<400> 3072 Met 1 Ala Glu Asn Asp Thr 5 Val Val Thr Glu 10 Phe Ile Leu Met Ala Phe 15 Gln Leu Ser Ala Gly Leu Gln Met Ser Leu Phe Phe Val Phe Leu Val 20 25 30 Leu Tyr Phe Val Thr Val Gly Gly Asn Leu Gly Met Ile Val Leu Ile 35 40 45 Gln Arg Asp Leu Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Arg His 50 55 60 Leu Ser Phe Leu Asp Ile Cys Tyr Ser Ser Val Ile Val Pro Gln Leu 65 70 75 80 Leu Glu Thr Leu Gly Thr Arg Lys Met Ala Ile Thr Tyr Glu Arg Cys 85 90 95 Ala Thr Gln Phe Phe Phe Phe Thr Leu Cys Ala Ser Thr Glu Cys Phe 100 105 110 Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Met Ala Val Cys Asn Pro 115 120 125 Leu Phe Tyr Ala Thr Ala Met Thr Pro Gln Thr Cys Leu Gly Leu Val 130 135 140 Ala Gly Ala Tyr Ala Cys Ala Met Val Ile Ala Val Ile Arg Thr Gly 145 150 155 160 Cys Thr Phe Ser Ile Ser Phe Cys Lys Ser Asn His Val Asp Phe Phe 165 170 175 Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Ala Cys Ser Glu Thr Lys

Page 3428

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069269_0225_SL.TXT 185 190

Pro Arg Glu 195 Arg Val Ile Tyr Leu Leu Ala Phe Leu Val Ile Thr Thr 200 205 Ser Ile Ser Val Ile Leu Ile Ser Tyr Phe Phe Ile Ile His Ala Ile 210 215 220 Leu Lys Ile Arg Thr Ala Gly Gly Lys Val Lys Thr Phe Ser Thr Cys 225 230 235 240 Val Ser His Met Thr Ala Val Ala Leu Phe Phe Gly Thr Leu Ile Phe 245 250 255 Ile Tyr Leu Lys Gly Asn Met Gly Ala Ser Leu Gly Glu Asp Lys Ile 260 265 270 Val Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro Met Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Leu Lys Lys Thr Leu 290 295 300 Asn Arg Ile Lys Val Ser Gln Xaa 305 310

<210> 3073 <211> 936 <212> DNA <213> Felis catus <400> 3073

atggcagaga agaacctcac ctccacgacc cagttcctcc ttactgcgtt cactgactgt 60 cctgaacagg ctctccctct cttcctcctc tttctgttga tctatctcat caccttgctg 120 gggaacacag gaatggtcat cctgatccgc gtggatggcc ggctccacac cccgatgtac 180 ttcctcctga gtcacctctc tttcatggac atctgctact cgtctgtcac ggtcccccag 240 atgctggcca tgctgctgga gcgcggggcg gctctgtcct acacacgctg tgccgctcag 300 ttcttcctct tcaccttctt tggctccatc gactgctacc tcctggcaat catggcctat 360

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gaccgctacg tggccgtgtg ccggcccctg ctttatgtca ccgtcatgac gcagaaggcc 420 cgtctgggtt ttgtggctgg ggcttacggt gctggtctct tcagtgcctc cgtgaggaca 480 gtctcggctt tcaccctctc cttctgtgga accaatgaga tcgactttat tttctgtgat 540 ctccctcccc tgttaaagct gacctgtggg gacagctaca cccaggaggt ggtcattatt 600 gtgtttgcga tatttgtcat ccctgcctgc atggcggcca tcttggtgtc ctacctgttc 660 atcatcgtgg ccatcatgag gatcccctca gcgggaggcc gggccaagac cttctccacg 720 tgtgcctccc acctcacggc cgtgtcactc ttcttcggca ctctcatctt catgtacctc 780 cgagacaact cgggccactc cttgcaggaa gatcgggtgg tggctgtgtt ttacacaaca 840 gtgatcccca tgctgaaccc cctcatttat agcctgagga accaggaagt gaaggaagcc 900 ctgaggaaag ttcttgaacg agctgagtgg tcctga 936

<210> 3074 <211> 311 <212> PRT <213> Felis catus

<400> 3074 Asn Leu 5 Thr Ser Thr Thr Gln Phe Leu Leu Thr Ala Met Ala 1 Glu Lys 10 15 Phe Thr Asp Cys Pro Glu Gln Ala Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 Leu Ile Tyr Leu Ile Thr Leu Leu Gly Asn Thr Gly Met Val Ile Leu 35 40 45 Ile Arg Val Asp Gly Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60 His Leu Ser Phe Met Asp Ile Cys Tyr Ser Ser Val Thr Val Pro Gln 65 70 75 80 Met Leu Ala Met Leu Leu Glu Arg Gly Ala Ala Leu Ser Tyr Thr Arg 85 90 95

Page 3430

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Cys Ala Ala Gln 100 Phe Phe Leu Phe Thr Phe Phe Gly Ser Ile Asp Cys 105 110 Tyr Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Arg 115 120 125 Pro Leu Leu Tyr Val Thr Val Met Thr Gln Lys Ala Arg Leu Gly Phe 130 135 140 Val Ala Gly Ala Tyr Gly Ala Gly Leu Phe Ser Ala Ser Val Arg Thr 145 150 155 160 Val Ser Ala Phe Thr Leu Ser Phe Cys Gly Thr Asn Glu Ile Asp Phe 165 170 175 Ile Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Thr Cys Gly Asp Ser 180 185 190 Tyr Thr Gln Glu Val Val Ile Ile Val Phe Ala Ile Phe Val Ile Pro 195 200 205 Ala Cys Met Ala Ala Ile Leu Val Ser Tyr Leu Phe Ile Ile Val Ala 210 215 220 Ile Met Arg Ile Pro Ser Ala Gly Gly Arg Ala Lys Thr Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Phe Gly Thr Leu Ile 245 250 255 Phe Met Tyr Leu Arg Asp Asn Ser Gly His Ser Leu Gln Glu Asp Arg 260 265 270 Val Val Ala Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Val Lys Glu Ala Leu Arg Lys Val 290 295 300

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Leu Glu Arg Ala Glu Trp Ser 305 310 <210> 3075 <211> 945 <212> DNA <213> Felis catus <400> 3075 atggctggga ggaatgacac tgtagtgacc gagttcttcc tcactgcgtt cccagagcat 60 cccgagtggg ggctccctct cttcctggtg tttttgagtt tctatctcct cactctgctg 120 gggaacacgg gaatggtcat cctgatccgt gtggatggcc ggcttcacac cccgatgtac 180 ttcttccttg gccacctttc cttcgtggac atctgctact cgtccgtcac ggtcccccag 240 atgctggcca tgctgctgga gcgcggggca gttctgtcct acacacgctg tgccgctcag 300 ttcttcctct tcaccttctt tgcttccatc gactgctacc tcctggcaat catggcctat 360 gaccgctatg tggccgtgtg ccggcccctg ctttatgtca ccgtcatgac cgagaaggcc 420 cgctggggct tactggctgc agcttatgcg gctggtttct ccagtgcctt tgttcggacg 480 gtcacagcct tcaccctctc cttctgtgga accaatgaga tcgactttat tttctgtgat 540 ctccctcccc tgttaaagct gacctgtggg gacagctaca cccaggaggt ggtcattatt 600 gtgtttgcca tttttgtcat gcctctttgt gtattggtga tcttggtgtc ctacgtgttt 660 atcatcgtgg ccatcatgag gatccgctcc tcggggggcc gggccaagac cttctccacg 720 tgtgtctccc acctcacggc cgtgtcactc ttcttcggca ctctcatctt catgtacctc 780 cgagacaact cgggccagtc ctcggaggag gaccgagcgg tgtcagtgct ctacacagtg 840 gtgaccccca tgctgaaccc cttcatctat agcctgagga ataaggaggt aaaggaggcg 900 gttgtgaaag ccctgagcag gtcaaagtct cgtggaaggc cctag 945 <210> 3076 <211> 314 <212> PRT <213> Felis catus <400> 3076

Met Ala Gly Arg Asn Asp Thr Val Val Thr Glu Phe Phe Leu Thr Ala 1 5 10 15

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Phe Pro Glu His 20 Pro Glu Trp Gly Leu Pro Leu Phe Leu Val Phe Leu 25 30 Ser Phe Tyr Leu Leu Thr Leu Leu Gly Asn Thr Gly Met Val Ile Leu 35 40 45 Ile Arg Val Asp Gly Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 His Leu Ser Phe Val Asp Ile Cys Tyr Ser Ser Val Thr Val Pro Gln 65 70 75 80 Met Leu Ala Met Leu Leu Glu Arg Gly Ala Val Leu Ser Tyr Thr Arg 85 90 95 Cys Ala Ala Gln Phe Phe Leu Phe Thr Phe Phe Ala Ser Ile Asp Cys 100 105 110 Tyr Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Arg 115 120 125 Pro Leu Leu Tyr Val Thr Val Met Thr Glu Lys Ala Arg Trp Gly Leu 130 135 140 Leu Ala Ala Ala Tyr Ala Ala Gly Phe Ser Ser Ala Phe Val Arg Thr 145 150 155 160 Val Thr Ala Phe Thr Leu Ser Phe Cys Gly Thr Asn Glu Ile Asp Phe 165 170 175 Ile Phe Cys Asp Leu Pro Pro Leu Leu Lys Leu Thr Cys Gly Asp Ser 180 185 190 Tyr Thr Gln Glu Val Val Ile Ile Val Phe Ala Ile Phe Val Met Pro 195 200 205 Leu Cys Val Leu Val Ile Leu Val Ser Tyr Val Phe Ile Ile Val Ala 210 215 220

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Ile 225 Met Arg Ile Arg Ser Ser Gly Gly Arg Ala Lys Thr Phe Ser Thr 230 235 240 Cys Val Ser His Leu Thr Ala Val Ser Leu Phe Phe Gly Thr Leu Ile 245 250 255 Phe Met Tyr Leu Arg Asp Asn Ser Gly Gln Ser Ser Glu Glu Asp Arg 260 265 270 Ala Val Ser Val Leu Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Val Val Lys Ala 290 295 300 Leu Ser Arg Ser Lys Ser Arg Gly Arg Pro 305 310

<210> 3077 <211> 925 <212> DNA <213> Felis catus <400> 3077

ttttcctact gaggagcttt cttagggcac ctttcatgtc cttgttcctc aggctataga 60 tgaaggggtt catcatgggc gtcaccacgg tgaatagcac tgcaccaatc ttatctccgc 120 catcagggtg agtggttgag gggaagaagt aaacccctac aatggtccca tagaagagca 180 atacaactgt caggtgagag ccacaggtag agaaggcttt ccactttcct tctgtggatg 240 agattctcag gacagccctg acaatgcaga tgtaggagaa gagaatgagg gcaaagggga 300 aggtgacaac cgataagccc gcgataaata atacgagttc attgatcctt gtgtctgagc 360 aggacagctt gagcagaggc gccaagtcac agaagaagtg tgggagagtg ttgctgtcac 420 agaaaagcaa cggaaggagt agaagagtgt gtattagggc aacagcatta ctgaggaccc 480 acggaatgac cgcgagtgaa acgcagagcc tgggttgcat gatggtcatg tagttcagag 540 ggtggcagat agccacaaag cggtcatagg ccatgacgcc caagaggaaa ttgtcaataa 600 cgacaaacac aatagaaaag tacatttgtg tgatgcagtt ctcataggag atggattgag 660

Page 3434

069269_0225_SL.TXT tcttggtctg aatattcatc agcatcttgg ggactgaggt ggatacggag gaaatatcag caaaggatag attggcaagg aagaaataca tgggagtgtg aaggtaagaa tccaagccga tggccaggat gatgagtcca ttcccaacta cagtgaccag gtacataccc aggaaaagca caaagaggac cttctgctgc tcagcctggt tggagagtcc cagaaggagg aacccagaga cggtggttcg atttccttga tgcat

720

780

840

900

925 <210> 3078 <211> 309 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (309)..(309) <223> Any amino acid <400> 3078

Met His Gln Gly Asn Arg Thr Thr Val Ser Gly Phe Leu Leu Leu Gly 1 5 10 15 Leu Ser Asn Gln Ala Glu Gln Gln Lys Val Leu Phe Val Leu Phe Leu 20 25 30 Gly Met Tyr Leu Val Thr Val Val Gly Asn Gly Leu Ile Ile Leu Ala 35 40 45 Ile Gly Leu Asp Ser Tyr Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Ala Asp Ile Ser Ser Val Ser Thr Ser Val Pro Lys 65 70 75 80 Met Leu Met Asn Ile Gln Thr Lys Thr Gln Ser Ile Ser Tyr Glu Asn 85 90 95 Cys Ile Thr Gln Met Tyr Phe Ser Ile Val Phe Val Val Ile Asp Asn 100 105 110

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Phe Leu Leu 115 Gly Val Met Ala 069269_0225_SL.TXT Tyr Asp Arg Phe Val Ala 120 125 Ile Cys His Pro Leu Asn Tyr Met Thr Ile Met Gln Pro Arg Leu Cys Val Ser Leu 130 135 140 Ala Val Ile Pro Trp Val Leu Ser Asn Ala Val Ala Leu Ile His Thr 145 150 155 160 Leu Leu Leu Leu Pro Leu Leu Phe Cys Asp Ser Asn Thr Leu Pro His 165 170 175 Phe Phe Cys Asp Leu Ala Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190 Arg Ile Asn Glu Leu Val Leu Phe Ile Ala Gly Leu Ser Val Val Thr 195 200 205 Phe Pro Phe Ala Leu Ile Leu Phe Ser Tyr Ile Cys Ile Val Arg Ala 210 215 220 Val Leu Arg Ile Ser Ser Thr Glu Gly Lys Trp Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Leu Leu Phe Tyr Gly Thr Ile Val 245 250 255 Gly Val Tyr Phe Phe Pro Ser Thr Thr His Pro Asp Gly Gly Asp Lys 260 265 270 Ile Gly Ala Val Leu Phe Thr Val Val Thr Pro Met Met Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Arg Lys Leu 290 295 300 Leu Ser Arg Lys Xaa

305

Page 3436

069269_0225_SL.TXT <210> 3079 <211> 945 <212> DNA <213> Felis catus <400> 3079

ctagttgttc tgggagaggc aattcctggc aagaactctc cccagggtcc ccttcatttc 60 acggttcctc agggtgtaga taagtgggtt gagcagtggg gttcccaatg tgtacaccag 120 tgaaatgaac tgatcttgct tggggtagta gctggagttg gggcgcaggt acatgaaggc 180 acaacagcca tactgcagca ggaccacgga gaggtgggag gagcaggtgg agaaggcccg 240 gtggcggcca gttgccgagt ggatcttgag cacagcagcc acaatgaagg cgtaggaggt 300 ggcgatgaag aagaaaggca tggcaatggc caatgtggct gccaccagca ctgcccgctc 360 atggatgtgg ctgttggtgc aaacaagacg catcaccggt ggcacatcgc aaaagaagtg 420 ctcgatagtc cgcgcccggc agaatggcag cgagaagatg aaggccacca gttgtatgga 480 caggaacaag ccaatgacca cagaggccac gaccaagtgg acacagagag ttaaagtcac 540 agtgagcggg tactgcaagg gggagcaaat agcaacatac cggtcataag ccatggcagc 600 caagaggaag cagtcagcgc taccaagccc aatgaagaag atcatctgag tggcacagcc 660 caggagggtg atggtcttct ctgactggag gatgttggtc aggatgtggg gcaccaccac 720 agcagtgtag catagttcta ttcccgagag gctgcccagg aagtagtaca tggctgtgtg 780 caggcgtgct tctgtatgga tggccaccac aatgaagaca ttcccaccaa tgatcaagat 840 ataaaccagg ctgactccaa ggaaaaacaa gacctggagc tctgggggag acggataggc 900 caagaacaca aattccatca acattgagtg atttccccag gtcat 945

<210> 3080 <211> 314 <212> PRT <213> Felis catus <400> 3080

Met Thr Trp Gly Asn His Ser Met Leu Met Glu Phe Val Phe Leu Ala 1 5 10 15

Tyr Pro Ser Pro Pro Glu Leu Gln Val Leu Phe Phe Leu Gly Val Ser 20 25 30

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Leu Val Tyr 35 Ile Leu Ile Ile Gly Gly Asn Val Phe Ile Val Val Ala 40 45 Ile His Thr Glu Ala Arg Leu His Thr Ala Met Tyr Tyr Phe Leu Gly 50 55 60 Ser Leu Ser Gly Ile Glu Leu Cys Tyr Thr Ala Val Val Val Pro His 65 70 75 80 Ile Leu Thr Asn Ile Leu Gln Ser Glu Lys Thr Ile Thr Leu Leu Gly 85 90 95 Cys Ala Thr Gln Met Ile Phe Phe Ile Gly Leu Gly Ser Ala Asp Cys 100 105 110 Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Gln Tyr Pro Leu Thr Val Thr Leu Thr Leu Cys Val His Leu 130 135 140 Val Val Ala Ser Val Val Ile Gly Leu Phe Leu Ser Ile Gln Leu Val 145 150 155 160 Ala Phe Ile Phe Ser Leu Pro Phe Cys Arg Ala Arg Thr Ile Glu His 165 170 175 Phe Phe Cys Asp Val Pro Pro Val Met Arg Leu Val Cys Thr Asn Ser 180 185 190 His Ile His Glu Arg Ala Val Leu Val Ala Ala Thr Leu Ala Ile Ala 195 200 205 Met Pro Phe Phe Phe Ile Ala Thr Ser Tyr Ala Phe Ile Val Ala Ala 210 215 220 Val Leu Lys Ile His Ser Ala Thr Gly Arg His Arg Ala Phe Ser Thr 225 230 235 240

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Cys Ser Ser His Leu Ser Val Val Leu Leu Gln Tyr Gly Cys Cys Ala 245 250 255 Phe Met Tyr Leu Arg Pro Asn Ser Ser Tyr Tyr Pro Lys Gln Asp Gln 260 265 270 Phe Ile Ser Leu Val Tyr Thr Leu Gly Thr Pro Leu Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Arg Glu Met Lys Gly Thr Leu Gly Arg Val 290 295 300 Leu Ala Arg Asn Cys Leu Ser Gln Asn Asn 305 310

<210> 3081 <211> 960 <212> DNA <213> Felis catus <400> 3081

tcagagagct tcacctgttc ctttgctact gatggccttt ttcagggcac ctttgacatc 60 cttgttccta agggtgtaaa tcagcgggtt gagtaggggg gtgatgaagg tgtagactag 120 ggcaaactgg cggtcctcat ccaccgacga gcccgactgg ggacgcaggt agaccaaggc 180 acagaagcca tactgcagca ggaccacggt gaggtgcgac gagcaggtgg agaaggcccg 240 gcggcggccc tcggcggagc ggatgcgcag gatggcggag gcgatgaaca cgtaggacac 300 gcagataagc aggaagggga cggtcagcac caggatgccc accacgtaga gcacggcctg 360 gtgcacgcgg atgtcggcgc aggccagccg caggacggga ggcacgtcgc acaggaagtg 420 gttgatttcc cggcggtgcc cgcagaaggg caaggtgaag atcaagcaag tgagctgcag 480 ggagaggagg agggccaggc ccagggcgca cagcaccatc cggacgcaca gcttctgggt 540 catgatgagg gtgtagcgca gcgggtggca gatggccacg tagcgatcgt atgccatgat 600 tgccaagagg aagcagtcag cgccgccaag cgtgagaaaa aagaacattt gggccccaca 660 gccagccagc ggaatgggtt tccgggcgcc gcaaaggttg gcaagcatca gaggcaccac 720 cactgtggtg tagctgatct ctacgaaaga caggttgcac aggaagaagt acatgggggt 780

Page 3439

069269_0225_SL.TXT gtgcagcgag ctgtgtgtgc gcaccgccca gacgatggcc gcgttgccac aaaggatcat caagtagagc aggaggaaga ggaggaagag gagggcctgc aattcgggga cggtggtgaa cgcgcggaac acgaactcgg tggggccgga ctggttgagg acggggctcc tggcaaacat

840

900

960 <210> 3082 <211> 319 <212> PRT <213> Felis catus

<400> 3082 Pro Val Leu Asn Gln Ser Gly Pro Thr Glu Phe Met Phe 1 Ala Arg Ser 5 10 15 Val Phe Arg Ala Phe Thr Thr Val Pro Glu Leu Gln Ala Leu Leu Phe 20 25 30 Leu Leu Phe Leu Leu Leu Tyr Leu Met Ile Leu Cys Gly Asn Ala Ala 35 40 45 Ile Val Trp Ala Val Arg Thr His Ser Ser Leu His Thr Pro Met Tyr 50 55 60 Phe Phe Leu Cys Asn Leu Ser Phe Val Glu Ile Ser Tyr Thr Thr Val 65 70 75 80 Val Val Pro Leu Met Leu Ala Asn Leu Cys Gly Ala Arg Lys Pro Ile 85 90 95 Pro Leu Ala Gly Cys Gly Ala Gln Met Phe Phe Phe Leu Thr Leu Gly 100 105 110 Gly Ala Asp Cys Phe Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Thr Leu Ile Met Thr Gln Lys Leu 130 135 140 Cys Val Arg Met Val Leu Cys Ala Leu Gly Leu Ala Leu Leu Leu Ser 145 150 155 160

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Leu Gln Leu Thr Cys Leu Ile Phe Thr Leu Pro Phe Cys Gly His Arg 165 170 175 Arg Glu Ile Asn His Phe Leu Cys Asp Val Pro Pro Val Leu Arg Leu 180 185 190 Ala Cys Ala Asp Ile Arg Val His Gln Ala Val Leu Tyr Val Val Gly 195 200 205 Ile Leu Val Leu Thr Val Pro Phe Leu Leu Ile Cys Val Ser Tyr Val 210 215 220 Phe Ile Ala Ser Ala Ile Leu Arg Ile Arg Ser Ala Glu Gly Arg Arg 225 230 235 240 Arg Ala Phe Ser Thr Cys Ser Ser His Leu Thr Val Val Leu Leu Gln 245 250 255 Tyr Gly Phe Cys Ala Leu Val Tyr Leu Arg Pro Gln Ser Gly Ser Ser 260 265 270 Val Asp Glu Asp Arg Gln Phe Ala Leu Val Tyr Thr Phe Ile Thr Pro 275 280 285 Leu Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Gly 290 295 300 Ala Leu Lys Lys Ala Ile Ser Ser Lys Gly Thr Gly Glu Ala Leu

305 310 315 <210> 3083 <211> 952 <212> DNA <213> Felis catus <400> 3083 ttagtaggct aaacccaatg aagactttgc ttttccaacc accttctgaa atgcaccctt gacctctttg ttccttaggc tgtagaccaa agggttcagc atggggatga ccatggtgta

120

Page 3441

069269_0225_SL.TXT gaacacggac gccattttgt ctgtgttcat ggaatgacta gaacttggct gtaagtacgt gaagatgatt gtcccgtaga agatggaaac agtggtaagg tgggatgcac aggtggagaa agccttcttc tgcacctgag ctgagcgcat cctcaggata gcaataaaaa tgaacagata agagttcaag ataaccaaga gggtgaaaaa gacattgaat gctgccagtg tgaagagcac aatctcattc atgtagatat cagagcaaga gagagacagc attgggggaa tgtcacagaa aaagtgatta attacattgg aatgacagaa agagaggtgg aaagtgaaaa caacatggat ggaagactgc aagagtccac agatgtagga tccagtggcc agtaaggtac acatagcact tgtcatggtg gtggtgtaac gcaaaggttt gcacacggct gcatggcggt caaaggccat tgaggccaga aggaaacttt caatagtggc aaaggctgag aagaagaaca tctgtgcagc acatgcattg taggatatga tcttatctcc tgtgagaaac cccaccatta ccttgggagt gacagccgag gcataaacgc agtccacgag ggagaggttg ctgaggaaga agtacatggg agtgtggaga cgagagtcca acagaatcaa cacgatcatt ccaacgttcc caaccagaat gatgaggtaa atgatagtga agatggtaaa caaagggacc tgcatctcca gggcatctgt gagccccaca agaatgaatt ccaccacctc tgaaatgttc tccatcaaag tc <210> 3084 <211> 314 <212> PRT <213> Felis catus

180

240

300

360

420

480

540

600

660

720

780

840

900

952

<400> 3084 Met Glu Asn Ile 1 Ser 5 Glu Val Val Glu Phe Ile Leu Val Gly Leu Thr 10 15 Asp Ala Leu Glu Met Gln Val Pro Leu Phe Thr Ile Phe Thr Ile Ile 20 25 30 Tyr Leu Ile Ile Leu Val Gly Asn Val Gly Met Ile Val Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Cys Val Tyr Ala Ser Ala Val Thr Pro Lys Val Met Page 3442

069269_0225_SL.TXT

Val Gly Phe Leu Thr Gly Asp Lys Ile Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Ala Gln Met Phe Phe Phe Ser Ala Phe Ala Thr Ile Glu Ser Phe Leu 100 105 110 Leu Ala Ser Met Ala Phe Asp Arg His Ala Ala Val Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Thr Thr Met Thr Ser Ala Met Cys Thr Leu Leu Ala Thr 130 135 140 Gly Ser Tyr Ile Cys Gly Leu Leu Gln Ser Ser Ile His Val Val Phe 145 150 155 160 Thr Phe His Leu Ser Phe Cys His Ser Asn Val Ile Asn His Phe Phe 165 170 175 Cys Asp Ile Pro Pro Met Leu Ser Leu Ser Cys Ser Asp Ile Tyr Met 180 185 190 Asn Glu Ile Val Leu Phe Thr Leu Ala Ala Phe Asn Val Phe Phe Thr 195 200 205 Leu Leu Val Ile Leu Asn Ser Tyr Leu Phe Ile Phe Ile Ala Ile Leu 210 215 220 Arg Met Arg Ser Ala Gln Val Gln Lys Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Thr Val Ser Ile Phe Tyr Gly Thr Ile Ile Phe Thr 245 250 255 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asn Thr Asp Lys Met Ala 260 265 270 Ser Val Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Leu Val Tyr

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069269_0225_S ;l.tx T 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Phe Gln Lys Val Val Gly 290 295 300 Lys Ala Lys Ser Ser Leu Gly Leu Ala Tyr 305 310

<210> 3085 <211> 945 <212> DNA <213> Felis catus <400> 3085

ctaggaggtg aagcttagag acaggtttgc cttaacaacc ttcttgaaag cattcttgac 60 ctctttgttc cttaggctat acaccgcagg atttagcatg ggaatgacca tagtatagaa 120 cacagacaca attttgtcca tgtccataga atggctggag gttggctggg agtacataaa 180 catgactgtc ccatagaaga tggagactgc agtgaggtga gaagcacagg tggatatagc 240 tttcaggtat ccctctattg agggcatttt caagatggtg gtaaatacga acaggtagga 300 aatcaaaata accaaaagac caaaaaaaga tgtggaagct tgctaccaaa acaagaacca 360 gctcactgac atgtctatca gaacaagaga gagagagaca actgcaggaa tatcacagaa 420 aaagtgatgg atcacattgg acttacagaa gaagaggtgg aatgtgtttc caacatccac 480 agaagcattc agaaaaccaa aaacatagga gcctatagcc aaacgagcac acacacctgt 540 cgtcatggtg gtggtgtaat ggaggggttt gcacaccgct gcatagtggt cataggccat 600 tgaggccaag aggtaactct ccaccgtggc aaaggctgca aaaaagaaca tctgagtagc 660 acacgcattg taggagatga gcttgtctct tataagtaat ccagccagga ccctgggagt 720 gacagctgta gagtaaccaa agtccaccag agacaggtta ctgaggaaaa agtacatggg 780 agtgtggaga cgagagtcca acagaatcag cgccatcatc cccaggtttc caaccacact 840 gatgaggtag atgagggtga acatgataaa gaggggggcc agcagttctg ggtcactggt 900 tagtcccagc aagatgaatt cagtcacttc tgtgttgttc ttcat 945

<210> 3086 <211> 200

Page 3444

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 3086 Thr Glu Val Thr Glu Phe Ile Leu Leu Gly Leu Thr Met 1 Lys Asn Asn 5 10 15 Ser Asp Pro Glu Leu Leu Ala Pro Leu Phe Ile Met Phe Thr Leu Ile 20 25 30 Tyr Leu Ile Ser Val Val Gly Asn Leu Gly Met Met Ala Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Gly Tyr Ser Thr Ala Val Thr Pro Arg Val Leu 65 70 75 80 Ala Gly Leu Leu Ile Arg Asp Lys Leu Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Thr Gln Met Phe Phe Phe Ala Ala Phe Ala Thr Val Glu Ser Tyr Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp His Tyr Ala Ala Val Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Thr Gly Val Cys Ala Arg Leu Ala Ile 130 135 140 Gly Ser Tyr Val Phe Gly Phe Leu Asn Ala Ser Val Asp Val Gly Asn 145 150 155 160 Thr Phe His Leu Phe Phe Cys Lys Ser Asn Val Ile His His Phe Phe 165 170 175 Cys Asp Ile Pro Ala Val Val Ser Leu Ser Leu Val Leu Ile Asp Met 180 185 190

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069269_0225_SL.TXT Ser Val Ser Trp Phe Leu Phe Trp

195 200 <210> 3087 <211> 935 <212> DNA <213> Felis catus <400> 3087

tcattaagac aaaacctaga gaaaaatttg cctttttaac aacctttttg aatgcattct 60 tgacctcttt gttcctcagg ctatagacca cagggttcag catggggatg accatggtgt 120 agaacacgga tgcaattttg tctgtgtcca tggaatggct ggaacttggc tgtaagtaca 180 tgatgatgac tgtcccataa aatatggaaa ctgtaatgag gtgagacaca caggtggata 240 aagccttctg gtatccctca cctgagtgta tcttcagaat ggtagtaaat atgaacaggt 300 aggaaataaa gatgacaaaa agtgcaaaaa agacattgaa gcttgagata aaaacaagaa 360 tcagctcact tttgtgttta tcagagcacg tcaaagtcat gacagctgga atatcacaga 420 aaaagtgatg aaccacattg gacacacaga aagagagact aaaggtgtct ccaatgttta 480 tagaggcatt taagacacca caggcatagg agcctatggc cagatgagca cacacacctg 540 tcgtcatggt ggtggtgtaa tggaggggtt tgcacactgc tgcatagcgg tcataggcca 600 ttgaggccaa gaggtaattt tccacagtgg caaagactgc aaaaaagaac atctgggcag 660 cacatgcatt gtaggagatg agcttgtctc ccattaggag cccagccatg accttgggag 720 tgactgttga ggagtaacaa aagtcaacca gagacaggtt actgaggaag aaatacatag 780 gagtgtggag acaagagtcc agcaagatca gcacgatcat ccccaggttt ccaatcagag 840 tgacgaggta gatgagcgtg aacattataa agagaggaaa ctgcagttct gggttatcgg 900 ttagtcccag caggatgaaa ttggtcacgt ctgta 935

<210> 3088 <211> 312 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (312)..(312)

Page 3446

069269_0225_SL.TXT <223> Any amino acid

<400> 3088 Leu Gly Leu Thr Asp Asn Pro Glu Thr 1 Asp Val Thr Asn 5 Phe Ile Leu 10 15 Leu Gln Phe Pro Leu Phe Ile Met Phe Thr Leu Ile Tyr Leu Val Thr 20 25 30 Leu Ile Gly Asn Leu Gly Met Ile Val Leu Ile Leu Leu Asp Ser Cys 35 40 45 Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Leu Val Asp 50 55 60 Phe Cys Tyr Ser Ser Thr Val Thr Pro Lys Val Met Ala Gly Leu Leu 65 70 75 80 Met Gly Asp Lys Leu Ile Ser Tyr Asn Ala Cys Ala Ala Gln Met Phe 85 90 95 Phe Phe Ala Val Phe Ala Thr Val Glu Asn Tyr Leu Leu Ala Ser Met 100 105 110 Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu His Tyr Thr Thr 115 120 125 Thr Met Thr Thr Gly Val Cys Ala His Leu Ala Ile Gly Ser Tyr Ala 130 135 140 Cys Gly Val Leu Asn Ala Ser Ile Asn Ile Gly Asp Thr Phe Ser Leu 145 150 155 160 Ser Phe Cys Val Ser Asn Val Val His His Phe Phe Cys Asp Ile Pro 165 170 175 Ala Val Met Thr Leu Thr Cys Ser Asp Lys His Lys Ser Glu Leu Ile 180 185 190 Leu Val Phe Ile Ser Ser Phe Asn Val Phe Phe Ala Leu Phe Val Ile

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069269_0225_SL.TXT

195 200 205 Phe Ile Ser Tyr Leu Phe Ile Phe Thr Thr Ile Leu Lys Ile His Ser 210 215 220 Gly Glu Gly Tyr Gln Lys Ala Leu Ser Thr Cys Val Ser His Leu Ile 225 230 235 240 Thr Val Ser Ile Phe Tyr Gly Thr Val Ile Ile Met Tyr Leu Gln Pro 245 250 255 Ser Ser Ser His Ser Met Asp Thr Asp Lys Ile Ala Ser Val Phe Tyr 260 265 270 Thr Met Val Ile Pro Met Leu Asn Pro Val Val Tyr Ser Leu Arg Asn 275 280 285 Lys Glu Val Lys Asn Ala Phe Lys Lys Val Val Lys Lys Ala Asn Phe 290 295 300 Ser Leu Gly Phe Val Leu Met Xaa

305 310

<210> 3089 <211> 939 <212> DNA <213> Felis catus <400> 3089 tcacagtctt aaagataatt ttgcctctga aatgaccttc atgagtgcac tcttaacctc 60 tttgttcctc aggctataga ccacagggtt cagcatgggg atgaccatgg tgtagaacac 120 agatgccatt ttgtctgtgt ccatggaatg gctggaactg ggctgtaagt acataaaaat 180 gagtgtccca tagaagatgg agactgcaga gaggtgagaa gcacaggtag ataaagcctt 240 ctgatatcct gtagatgagt gcatctttag aatggtgata aatatgaata tgtaggaaat 300 caagatgacc atgagagcaa aaaagctgtt gaagctcact acataaacaa gaaccagctc 360 actgacacgt ctatcagagc aagaaagaac cacgactgca ggcacatcac agaaaaaatg 420 atgaatcaca ttggacatac aaaaggagag tctgaacgtg tctccagtgt ggatagaggc 480

Page 3448

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attcaggaaa ccacaggtgt aggaacctat ggccagacat gcacacacac ctgtcgtcat 540 ggtggtggtg taatggaggg gtttgcacac tgctgcatag cggtcatagg ccattgaagc 600 caacaggtaa ctctccacag tggcaaaggc tgcaaaaaag aacatctgag cagcacatgc 660 attgtaggag atgaccttgt ctcccataag taatccagcc atgaccttgg gagtgacagc 720 tgtagagtaa caaaggtcca ccagagacag gttactgagg aaaaagtaca tgggagtgtg 780 gagacgagag tccaacagaa tcaacactat tatccccagg tttccaacca gagtgatgag 840 gtagatgagg gtgaacacga taaagagggg aacctgcagt tctggatcac tggttagtcc 900 cagcaagatg aactgcgtca cttttgtcct gttatccat 939

<210> 3090 <211> 312 <212> PRT <213> Felis catus

<400> 3090 Lys Val Thr Gln Phe Ile Leu Leu Gly Leu Thr Met Asp 1 Asn Arg Thr 5 10 15 Ser Asp Pro Glu Leu Gln Val Pro Leu Phe Ile Val Phe Thr Leu Ile 20 25 30 Tyr Leu Ile Thr Leu Val Gly Asn Leu Gly Ile Ile Val Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Leu Cys Tyr Ser Thr Ala Val Thr Pro Lys Val Met 65 70 75 80 Ala Gly Leu Leu Met Gly Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Ala Gln Met Phe Phe Phe Ala Ala Phe Ala Thr Val Glu Ser Tyr Leu 100 105 110

Page 3449

Leu Ala Ser 115 Met Ala Tyr Asp 069269_0225_SL.TXT Arg Tyr Ala Ala Val Cys 120 125 Lys Pro Leu His Tyr Thr Thr Thr Met Thr Thr Gly Val Cys Ala Cys Leu Ala Ile 130 135 140 Gly Ser Tyr Thr Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asp 145 150 155 160 Thr Phe Arg Leu Ser Phe Cys Met Ser Asn Val Ile His His Phe Phe 165 170 175 Cys Asp Val Pro Ala Val Val Val Leu Ser Cys Ser Asp Arg Arg Val 180 185 190 Ser Glu Leu Val Leu Val Tyr Val Val Ser Phe Asn Ser Phe Phe Ala 195 200 205 Leu Met Val Ile Leu Ile Ser Tyr Ile Phe Ile Phe Ile Thr Ile Leu 210 215 220 Lys Met His Ser Ser Thr Gly Tyr Gln Lys Ala Leu Ser Thr Cys Ala 225 230 235 240 Ser His Leu Ser Ala Val Ser Ile Phe Tyr Gly Thr Leu Ile Phe Met 245 250 255 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala 260 265 270 Ser Val Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Val Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Leu Met Lys Val Ile Ser 290 295 300 Glu Ala Lys Leu Ser Leu Arg Leu

305 310

Page 3450

069269_0225_SL.TXT <210> 3091 <211> 930 <212> DNA <213> Felis catus <400> 3091

atggacacta atacagaagt gacagatttc atcctgatgg atctgaccaa tactccaaaa 60 cttcagattc cactttttat tgtgttcacc cctcatttac ttcatcagtg tttgggggaa 120 ccttgggatg atcatactga tcctactgga ctcccattgc cactctctca tgtacttttt 180 cctcagtaac ctgtctctgg tggactttgg ttactctgca gctgtcactc ccagggtcac 240 ggctggattc cttataggag accaggtcat ctcctataat gcgtgtgctg ctcaaacgtt 300 ctcttctgca gcctttgcaa ctgtggaacg ttatctctta tcctcagcgg cccgtgacct 360 ctgcgcagca gtgtgaagcc cctccatccc accaccacca tgacgatgag cgtgtgtgct 420 cttctggcca tgggttgcta catctgtagt ctcctgaatg catccattca ggttgggaat 480 acgttcagtc tttctttctg tcagtccaat gtggtccatc actttttcct gtgatattcc 540 agcagtcatg gctctctctt gctttgataa acacattagt aaggtggttc ttgtgtatgt 600 gtcaagcttt aatgtctttt ttgctcttct cgttataatc ctatcctatc tattcatatt 660 tataaccagc ttgaagatgc agtcagctca ggggcaccaa aaggctttgt ccacctgcac 720 ttcccacctc actacagtct ccatcttcta tgggacagtc atctttatgt atttacagcc 780 cagttccagc cattccatgg acacagacaa aacggcatcc gtgttctaca ctgtgctcat 840 ccccatgctg aaccctgtgg tctacagcct gaggaacaaa gaggtcaaga atgctttcaa 900 taaagttttg gaaaaggcaa aatcatctct 930

<210> 3092 <211> 158 <212> PRT <213> Felis catus <400> 3092

Met His Pro Phe Arg Leu Gly Ile Arg Ser Val Phe Leu Ser Val Ser 1 5 10 15

Pro Met Trp Ser Ile Thr Phe Ser Cys Asp Ile Pro Ala Val Met Ala 20 25 30

Page 3451

069269_0225_SL.TXT

Leu Ser Cys 35 Phe Asp Lys His Ile Ser Lys Val Val Leu Val Tyr Val 40 45 Ser Ser Phe Asn Val Phe Phe Ala Leu Leu Val Ile Ile Leu Ser Tyr 50 55 60 Leu Phe Ile Phe Ile Thr Ser Leu Lys Met Gln Ser Ala Gln Gly His 65 70 75 80 Gln Lys Ala Leu Ser Thr Cys Thr Ser His Leu Thr Thr Val Ser Ile 85 90 95 Phe Tyr Gly Thr Val Ile Phe Met Tyr Leu Gln Pro Ser Ser Ser His 100 105 110 Ser Met Asp Thr Asp Lys Thr Ala Ser Val Phe Tyr Thr Val Leu Ile 115 120 125 Pro Met Leu Asn Pro Val Val Tyr Ser Leu Arg Asn Lys Glu Val Lys 130 135 140 Asn Ala Phe Asn Lys Val Leu Glu Lys Ala Lys Ser Ser Leu 145 150 155

<210> 3093 <211> 945 <212> DNA <213> Felis catus <400> 3093

atggataaca ggacagaaga gacacaattc atcctggtgg gactaaccag tgacccagaa 60 ctgctgatcc ccctttttat catgttcacc ctcatctatc tcatcaatgt ggttgggaac 120 ctggggatga tggcgctgat tctcttggac tcccgtctcc acactcccat gtactttttc 180 ctcagtaacc tgtctctggt ggatctttgt tactctacag ctgtcactcc caaggtcatg 240 gctggattac ttgtgggaga caaggtcatc tcctacaatg catgtgctgc tcagatgttc 300 ttttttgtag catttgccac tgtggaaaat tacctcttgg cctcaatggc ctatgaccgc 360 tacacagcag tgtgcaaacc cctccattat accaccacct tgaccacagg tgtgtgtgct 420

Page 3452

069269_0225_SL.TXT

tctctagcta taggctccta catctgtggt tttctgaatg cctctttcca tgttggggac 480 atattcagtc tgtctttatg taagtccaat ctgatccatc actttttctg tgatgttcca 540 gctgtcatgg ctctctcttg ctttgataaa cacgttagtg aactggttct tgtttttatg 600 tcaagcttta atgccctttt tgctcttctg gttatattga tttcctacct attcatattt 660 atttccatct tgaagatgca gtcagctcag gggtaccaaa aggctttgtc cacctgcgct 720 tcccacctca ctacagtctc catcttctat gggacagtca tctttatgta tttacagccc 780 agttccagcc attccatgga cacagacaaa atggcttccg tgttctattc tatggtcatc 840 cccatgctga atcctgtggt ctatagcctg agaaacaaag aggtcaagtg tgcattcaag 900 aaggtggtgg agaaggcaag tttttctaca ggattgggaa tttaa 945

<210> 3094 <211> 314 <212> PRT <213> Felis catus

<400> 3094 Glu Glu Thr Gln Phe Ile Leu Val Gly Leu Thr Met Asp 1 Asn Arg Thr 5 10 15 Ser Asp Pro Glu Leu Leu Ile Pro Leu Phe Ile Met Phe Thr Leu Ile 20 25 30 Tyr Leu Ile Asn Val Val Gly Asn Leu Gly Met Met Ala Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Leu Cys Tyr Ser Thr Ala Val Thr Pro Lys Val Met 65 70 75 80 Ala Gly Leu Leu Val Gly Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Ala Gln Met Phe Phe Phe Val Ala Phe Ala Thr Val Glu Asn Tyr Leu 100 105 110

Page 3453

069269_0225_SL.TXT

Leu Ala Ser Met 115 Ala Tyr Asp Arg Tyr Thr Ala Val Cys Lys Pro Leu 120 125 His Tyr Thr Thr Thr Leu Thr Thr Gly Val Cys Ala Ser Leu Ala Ile 130 135 140 Gly Ser Tyr Ile Cys Gly Phe Leu Asn Ala Ser Phe His Val Gly Asp 145 150 155 160 Ile Phe Ser Leu Ser Leu Cys Lys Ser Asn Leu Ile His His Phe Phe 165 170 175 Cys Asp Val Pro Ala Val Met Ala Leu Ser Cys Phe Asp Lys His Val 180 185 190 Ser Glu Leu Val Leu Val Phe Met Ser Ser Phe Asn Ala Leu Phe Ala 195 200 205 Leu Leu Val Ile Leu Ile Ser Tyr Leu Phe Ile Phe Ile Ser Ile Leu 210 215 220 Lys Met Gln Ser Ala Gln Gly Tyr Gln Lys Ala Leu Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Thr Val Ser Ile Phe Tyr Gly Thr Val Ile Phe Met 245 250 255 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala 260 265 270 Ser Val Phe Tyr Ser Met Val Ile Pro Met Leu Asn Pro Val Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Cys Ala Phe Lys Lys Val Val Glu 290 295 300 Lys Ala Ser Phe Ser Thr Gly Leu Gly Ile 305 310

Page 3454

069269_0225_SL.TXT <210> 3095 <211> 934 <212> DNA <213> Felis catus <400> 3095

atgaagaaca acacggaagt ggctgaattc atcctgctgg gactaaccaa tgacccaaag 60 ctacagatcc ttctatttat catgttcacc ctcatttacc tcatcacgct gttggaaaca 120 tggggatgat tgttttgatt ctcttagact ctcatctcca cactcccatg tactttttcc 180 tcagtaacct gtctctggtg gactttggtt actctacagc tgtcactccc aaagttatgg 240 ctgggctcct taagggagac aaagtcatct cttacaatgc atgtgctgcc cagatgttct 300 tttttggagc cttggccact gtggaaaatt tccttttggc ctcaatggcc tatgaccgct 360 acacagcagt gtgcaaaccc ctccattaca ccaccaccat gacgacaagg gtgtgtgcat 420 gtctggcgat aggttcctac atctatggtt tcttgaatgc ttccatccac attcggaaca 480 cgttcagtct ctcattctgc aagtccaatc tgatccatca ctttttctgt gatgttccag 540 ctgtcatggc tctatcttgt tctgatagac atgtcagtga acttattctt attgtggtag 600 caagcttcaa catctttttt gctgtctttg ttatcttgat ttcctacctg ctcatattta 660 tcaccatcct gaagatgcac tcaactcagg gttatcagaa ggctttatcc acgtgcactt 720 cccacctcac tacagtctcc atcttctatg ggacagccat atttatgtac tcccagccca 780 cctccagcca ttccatggac tcagacaaaa tcgcatccat gttctacact atggttattc 840 ccatgctgaa ccccctggtc tatagcttaa gaaacaagga ggttaaaact gctttcaaga 900 aggtgggtga gaaggcaaaa ctgtctctag gctt 934

<210> 3096 <211> 272 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (272)..(272) <223> Any amino acid

Page 3455

069269_0225_SL.TXT

<400> 3096 Val Leu Ile Leu Leu Asp Ser His Leu His Thr 15 Pro Met 1 Gly Met Ile 5 10 Met Tyr Phe Phe Leu Ser Asn Leu Ser Leu Val Asp Phe Gly Tyr Ser 20 25 30 Thr Ala Val Thr Pro Lys Val Met Ala Gly Leu Leu Lys Gly Asp Lys 35 40 45 Val Ile Ser Tyr Asn Ala Cys Ala Ala Gln Met Phe Phe Phe Gly Ala 50 55 60 Leu Ala Thr Val Glu Asn Phe Leu Leu Ala Ser Met Ala Tyr Asp Arg 65 70 75 80 Tyr Thr Ala Val Cys Lys Pro Leu His Tyr Thr Thr Thr Met Thr Thr 85 90 95 Arg Val Cys Ala Cys Leu Ala Ile Gly Ser Tyr Ile Tyr Gly Phe Leu 100 105 110 Asn Ala Ser Ile His Ile Arg Asn Thr Phe Ser Leu Ser Phe Cys Lys 115 120 125 Ser Asn Leu Ile His His Phe Phe Cys Asp Val Pro Ala Val Met Ala 130 135 140 Leu Ser Cys Ser Asp Arg His Val Ser Glu Leu Ile Leu Ile Val Val 145 150 155 160 Ala Ser Phe Asn Ile Phe Phe Ala Val Phe Val Ile Leu Ile Ser Tyr 165 170 175 Leu Leu Ile Phe Ile Thr Ile Leu Lys Met His Ser Thr Gln Gly Tyr 180 185 190 Gln Lys Ala Leu Ser Thr Cys Thr Ser His Leu Thr Thr Val Ser Ile 195 200 205

Page 3456

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Phe Tyr 210 Gly Thr Ala Ile Phe Met Tyr Ser Gln Pro Thr Ser Ser His 215 220 Ser Met Asp Ser Asp Lys Ile Ala Ser Met Phe Tyr Thr Met Val Ile 225 230 235 240 Pro Met Leu Asn Pro Leu Val Tyr Ser Leu Arg Asn Lys Glu Val Lys 245 250 255 Thr Ala Phe Lys Lys Val Gly Glu Lys Ala Lys Leu Ser Leu Gly Xaa 260 265 270

<210> 3097 <211> 771 <212> DNA <213> Felis catus <400> 3097 tgggctgaac ggaatcttca tcttcttagt ggatttcctg aaagcattat tcacctcttt 60 attccttaga ttgtagacag tagggctcaa catgaggact ctaattacac agaacacaaa 120 tcccatttgg tcattgtctg tggaatcact agaactgggt tgtaagtaca cgaacgtgac 180 agttccatag aagagggtga ctgcagtgag gtgtgaggca caggtggaga aggctttctt 240 ctgtccgtcg gctgagcgca tcctcaggag ggcaatgaat gtgaacagat aggaggtcaa 300 gattactatc agggcaaaac aaacttagaa atctactaag ataaagagca tgatctcatt 360 tatgtagttg tcacaacagg aaggagccta gattggggcg atatcacaga aaaagtgatg 420 gaccacattg gaatggcaga agaggcagaa ggtgaatcca gggtgggtga ccccagacat 480 agcagcctac tgtcatttga gcacacaagc tggtggtcac agcggtggta taatgtaagg 540 gcttacatac tgctgcaggc cgatcgtaag ccatgacctc tagcaagaaa cagtctacac 600 tggcaaaagc cgcacagaac acatgagcaa cacagtcacc agaggagttg actttatcct 660 ccgtgagaaa cccagccgtc accttggtag taacagttag gaagtaaacg gggtccacca 720 gagagaggtt acatacaaac aaaaagctga aataggccca taaatccaga g 771 <210> 3098 <211> 121

Page 3457

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 3098 Leu Asp Leu Trp 1 Ala 5 Tyr Phe Ser Phe Leu Phe Val Cys Asn Leu Ser 10 15 Leu Val Asp Pro Val Tyr Phe Leu Thr Val Thr Thr Lys Val Thr Ala 20 25 30 Gly Phe Leu Thr Glu Asp Lys Val Asn Ser Ser Gly Asp Cys Val Ala 35 40 45 His Val Phe Cys Ala Ala Phe Ala Ser Val Asp Cys Phe Leu Leu Glu 50 55 60 Val Met Ala Tyr Asp Arg Pro Ala Ala Val Cys Lys Pro Leu His Tyr 65 70 75 80

Thr Thr Ala Val Thr Thr Ser Leu Cys Ala Gln Met Thr Val Gly Cys 85 90 95

Tyr Val Trp Gly His Pro Pro Trp Ile His Leu Leu Pro Leu Leu Pro 110 100 105 Phe Gln Cys Gly Pro Ser Leu Phe Leu 115 120

<210> 3099 <211> 939 <212> DNA <213> Felis catus <400> 3099 atggataaca ggacaaaagt gacgcagttc atcttgctgg gactaaccag tgatccagaa ctgcaggttc ccctctttat cgtgttcacc ctcatctacc tcatcactct ggttggaaac ctggggataa tagtgttgat tctgttggac tctcgtctcc acactcccat gtactttttc ctcagtaacc tgtctctggt ggacctttgt tactctacag ctgtcacccc caaagtcttg actgcattac ttataagaga caaggtcatc tcctacaatg catgtgctgc tcagatgttc

120

180

240

300

Page 3458

069269_0225_SL.TXT

ttttttgtag catttgccac tgtggagagt tacctgttgg cttcaatggc ctatgaccgc 360 tatgcagcag tgtgcaaacc cctccattac accaccacca tgacaatagg tgtgtgtgca 420 tgtctggcca tagtttccta cgcctgtggt ttcctgaatg cctctatcca cactggagac 480 acgttcagtc tctccttttg tatgtccaat gtgattcatc attttttctg tgatgtgcct 540 gcagtcgtgg ttctttcttg ctctgataga cgtgtcagtg agctggttct tgtttatgta 600 gtgagcttca acagcttttc tgctctcatg gtcatcttga tttcctacat attcatattt 660 atcaccatcc taaagatgca ctcatctaca ggatatcaga aggctttatc tacctgtgct 720 tctcacctct ctgcagtctc catcttctat gggacagtca tttttatgta cttacagccc 780 agttccagcc attccatgga cacagacaaa atggcatctg tgttctacac catggtcatc 840 cccatgctga accctgtggt ctatagcctg aggaacaaag aggttaagag tgcactcatg 900 aaggtcattt cagagacaaa attatcttta agattgtga 939

<210> 3100 <211> 312 <212> PRT <213> Felis catus <400> 3100

Met Asp 1 Asn Arg Thr 5 Lys Val Thr Gln Phe Ile Leu Leu Gly Leu Thr 10 15 Ser Asp Pro Glu Leu Gln Val Pro Leu Phe Ile Val Phe Thr Leu Ile 20 25 30 Tyr Leu Ile Thr Leu Val Gly Asn Leu Gly Ile Ile Val Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Leu Cys Tyr Ser Thr Ala Val Thr Pro Lys Val Leu 65 70 75 80 Thr Ala Leu Leu Ile Arg Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95

Page 3459

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Ala Gln Met Phe 100 Phe Phe Val Ala Phe Ala Thr Val Glu Ser Tyr Leu 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Ile Gly Val Cys Ala Cys Leu Ala Ile 130 135 140 Val Ser Tyr Ala Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asp 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys Met Ser Asn Val Ile His His Phe Phe 165 170 175 Cys Asp Val Pro Ala Val Val Val Leu Ser Cys Ser Asp Arg Arg Val 180 185 190 Ser Glu Leu Val Leu Val Tyr Val Val Ser Phe Asn Ser Phe Ser Ala 195 200 205 Leu Met Val Ile Leu Ile Ser Tyr Ile Phe Ile Phe Ile Thr Ile Leu 210 215 220 Lys Met His Ser Ser Thr Gly Tyr Gln Lys Ala Leu Ser Thr Cys Ala 225 230 235 240 Ser His Leu Ser Ala Val Ser Ile Phe Tyr Gly Thr Val Ile Phe Met 245 250 255 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Met Ala 260 265 270 Ser Val Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Val Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Ser Ala Leu Met Lys Val Ile Ser 290 295 300

Page 3460

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Glu Thr Lys Leu Ser Leu Arg Leu 305 310 <210> 3101 <211> 940 <212> DNA <213> Felis catus <400> 3101 atgaagaata atacagaggt gaaaggattc gtcctgctgg gactaaccaa taacacagag 60 ctgcaacttc ctctctttct aatgttcacc ctcatctacc tcgtcactct gattgggaac 120 ctggggatga tcatgctgat cctgttcgac tctcgtctcc acattcccat gtacttcttt 180 ctcagtaacc tgtccctggt agacttttgt tactcctcaa caatcactcc taaggtcatg 240 gctggattac ttataggaga caaggtcatc tcctacaatg cgtgtgccgc ccagatgttc 300 ttttttgttc tctttgcgac tgtggaaagt tacctcttag cttcaatggc ctatgaccgc 360 tacgcagcag tgtgcaaacc cctgcattac accaccacca tgacaacgag tgtgtgtgct 420 cgtctggcca taggctccta tgtctttgct tttctaactg ctgctattga cattggagac 480 acattcgatc tctctttctg tatgtccaat gtagtccatc actttttctg tgatattcca 540 gcagtcatga ccctggcttg ctcagataaa gacactaatg agctgattct tgttcttatt 600 tcaagcttta atatcttttt tgcagttcta gttatcttga tttcctacat gttcatattt 660 attaccgttt tgaagataca gtcaggtgag ggataccaaa aggctttatc tacctgtgct 720 tctcatcttg ttgcagtctc catattttat gggacagtca tcatcatgta tgtacagcca 780 agttcaagtc attccatgga tacagacaaa atcgcatctg tgttctatac tatggtcatc 840 cccatgctga accctgtggt ctacagcttg aggaacaaag aggtcaagaa tgctatcaag 900 aaggttgttg agagggcaaa atattctcta ggtttagtct 940 <210> 3102 <211> 314 <212> PRT <213> Felis catus <220>

<221> MOD_RES

Page 3461

069269_0225_SL.TXT <222> (314)..(314) <223> Any amino acid

<400> 3102 Thr Glu Val Lys Gly Phe Val Leu Leu Gly Leu Thr Met 1 Lys Asn Asn 5 10 15 Asn Asn Thr Glu Leu Gln Leu Pro Leu Phe Leu Met Phe Thr Leu Ile 20 25 30 Tyr Leu Val Thr Leu Ile Gly Asn Leu Gly Met Ile Met Leu Ile Leu 35 40 45 Phe Asp Ser Arg Leu His Ile Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Phe Cys Tyr Ser Ser Thr Ile Thr Pro Lys Val Met 65 70 75 80 Ala Gly Leu Leu Ile Gly Asp Lys Val Ile Ser Tyr Asn Ala Cys Ala 85 90 95 Ala Gln Met Phe Phe Phe Val Leu Phe Ala Thr Val Glu Ser Tyr Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Thr Ser Val Cys Ala Arg Leu Ala Ile 130 135 140 Gly Ser Tyr Val Phe Ala Phe Leu Thr Ala Ala Ile Asp Ile Gly Asp 145 150 155 160 Thr Phe Asp Leu Ser Phe Cys Met Ser Asn Val Val His His Phe Phe 165 170 175 Cys Asp Ile Pro Ala Val Met Thr Leu Ala Cys Ser Asp Lys Asp Thr 180 185 190

Page 3462

Asn Glu Leu 195 Ile Leu Val Leu 069269_0225_SL.TXT Ile Ser Ser Phe Asn Ile 200 205 Phe Phe Ala Val Leu Val Ile Leu Ile Ser Tyr Met Phe Ile Phe Ile Thr Val Leu 210 215 220 Lys Ile Gln Ser Gly Glu Gly Tyr Gln Lys Ala Leu Ser Thr Cys Ala 225 230 235 240 Ser His Leu Val Ala Val Ser Ile Phe Tyr Gly Thr Val Ile Ile Met 245 250 255 Tyr Val Gln Pro Ser Ser Ser His Ser Met Asp Thr Asp Lys Ile Ala 260 265 270 Ser Val Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Val Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Lys Asn Ala Ile Lys Lys Val Val Glu 290 295 300 Arg Ala Lys Tyr Ser Leu Gly Leu Val Xaa

305 310 <210> 3103 <211> 939 <212> DNA <213> Felis catus <400> 3103

ctatgggttg aacagaatct tcattttctt agtgactttc ctgaaagcat tatttacctc 60 tttattcctt agactgtaga caatagggtt cagcatgggg actattattg tatagaacac 120 agatgccatt tggtcattgt ccatagaatg gctagaactg ggttgtaagt acatgaacat 180 gacagctcca tagaagaggg tgactgcagt gagatgtgag gcacaggtgg agaaggcttt 240 cttccgtccc tcggctgagc acatcctcag gatggcaatg aatattaaca gataggaggt 300 caagattact atcagggcaa aacagacatt gaaagctgct aagataaaga gcacaatctc 360 atttatgtag atatcagagc aggaaagcgc caggattgga gggatatcac agaaaaagtg 420

Page 3463

069269_0225_SL.TXT

atggaccaca ttggaatggc agaaggagag gctgaaggtg aatccagtgt ggatggcaga 480 ttcaataaaa ccccagacat agcagcctac tgccatttga gcacacaagc tggtggtcac 540 agtggtggta taatgtaagg gcttacatac cgctgcatac cgatcataag ccatgacagc 600 tagcaggaaa cagtctacgc tggcaaaacc cacaaagaag aacatctgag cagcacatcc 660 accataggag atgattttat cccctgttag aaacccagcc atcaccttgg gagtaacagc 720 tgaggagtaa acacagtcta ccagagagag gttactgaga aaaatataca tgggagtgtg 780 gagacgggag tccaacagaa tcaacatgat catcccaaga tttccaatga gagtggtgag 840 ataaataaga gtaaatgtta tgaagagaaa gatttgcagt tctgggttgt cagtcagtcc 900 caagagtcta aactcattca ccttagtgcc gttctccat 939

<210> 3104 <211> 312 <212> PRT <213> Felis catus <400> 3104

Met Glu Asn Gly Thr Lys Val Asn Glu Phe Arg Leu Leu Gly Leu Thr 1 5 10 15 Asp Asn Pro Glu Leu Gln Ile Phe Leu Phe Ile Thr Phe Thr Leu Ile 20 25 30 Tyr Leu Thr Thr Leu Ile Gly Asn Leu Gly Met Ile Met Leu Ile Leu 35 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Ile Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Cys Val Tyr Ser Ser Ala Val Thr Pro Lys Val Met 65 70 75 80 Ala Gly Phe Leu Thr Gly Asp Lys Ile Ile Ser Tyr Gly Gly Cys Ala 85 90 95 Ala Gln Met Phe Phe Phe Val Gly Phe Ala Ser Val Asp Cys Phe Leu 100 105 110

Page 3464

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Leu Ala Val 115 Met Ala Tyr Asp Arg Tyr Ala Ala Val Cys Lys Pro Leu 120 125 His Tyr Thr Thr Thr Val Thr Thr Ser Leu Cys Ala Gln Met Ala Val 130 135 140 Gly Cys Tyr Val Trp Gly Phe Ile Glu Ser Ala Ile His Thr Gly Phe 145 150 155 160 Thr Phe Ser Leu Ser Phe Cys His Ser Asn Val Val His His Phe Phe 165 170 175 Cys Asp Ile Pro Pro Ile Leu Ala Leu Ser Cys Ser Asp Ile Tyr Ile 180 185 190 Asn Glu Ile Val Leu Phe Ile Leu Ala Ala Phe Asn Val Cys Phe Ala 195 200 205 Leu Ile Val Ile Leu Thr Ser Tyr Leu Leu Ile Phe Ile Ala Ile Leu 210 215 220 Arg Met Cys Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Leu Thr Ala Val Thr Leu Phe Tyr Gly Ala Val Met Phe Met 245 250 255 Tyr Leu Gln Pro Ser Ser Ser His Ser Met Asp Asn Asp Gln Met Ala 260 265 270 Ser Val Phe Tyr Thr Ile Ile Val Pro Met Leu Asn Pro Ile Val Tyr 275 280 285 Ser Leu Arg Asn Lys Glu Val Asn Asn Ala Phe Arg Lys Val Thr Lys 290 295 300 Lys Met Lys Ile Leu Phe Asn Pro

305 310

Page 3465

069269_0225_SL.TXT <210> 3105 <211> 945 <212> DNA <213> Felis catus <400> 3105

ttaaaatatg aatcctatag aagactttgc cttccctatg gcctttttaa aggcactctt 60 gacctctttg ttcctcaagc tgtagaccac aggatttagc atggggatga ccatggtata 120 gaacacggat gccactttgt ctgtgtccat ggaatggttg gcgctgggct gtaagtacat 180 gaaggtgccg gtcccgtaga agatggacac tgtagtgagg tgggaggtgc aggtggaaaa 240 ggccttctgg cgtccttcag atgagcgcat cctcagaata gtgataaata taaacaggta 300 ggagatcaag atgaccaaaa cagaaaagag attattcatg cccaccacca aaaaaataac 360 catctcactg atgtagttgt ctgaacatga gagagccaga agaggaggag catcacagaa 420 aaagtgatca accacactgg ctctacagaa ggagagcctg aaaatattcc cagtgtggat 480 ggacgcattc aggaaaccac aaatgtagca gcccatgacc agactagcac acataactgt 540 cgtcatggtg gtggtgtaat gcaggggtct gcacactgct acgtagcggt cataggccat 600 tgaggccaag aggaaacttt ctacagtgat aaaggctaca aagaaaaaga actgggtgac 660 acaagcatca taggagatga ccccgtctcc tgtaagtgat ccagccatga ccttgggagt 720 gatagcagta gagtaaccaa agtccaccag agacaggtga ctgaggaaaa agtacatggg 780 agtatggaga cgagagtcca agagaatcag caccatcatc cccaggttcc ccaaaagagt 840 gacaagataa atgagggcga agattaagaa gagaggaatc tgcagttttg ggtcattggt 900 taaccccaca agaatgaact cagtcacctc agtgctgttc tccat 945

<210> 3106 <211> 314 <212> PRT <213> Felis catus <400> 3106

Met Glu Asn Ser Thr Glu Val Thr Glu Phe Ile Leu Val Gly Leu Thr 1 5 10 15

Asn Asp Pro Lys Leu Gln Ile Pro Leu Phe Leu Ile Phe Ala Leu Ile 20 25 30

Page 3466

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Tyr Leu Val 35 Thr Leu Leu Gly Asn Leu Gly Met Met Val Leu Ile Leu 40 45 Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser His Leu 50 55 60 Ser Leu Val Asp Phe Gly Tyr Ser Thr Ala Ile Thr Pro Lys Val Met 65 70 75 80 Ala Gly Ser Leu Thr Gly Asp Gly Val Ile Ser Tyr Asp Ala Cys Val 85 90 95 Thr Gln Phe Phe Phe Phe Val Ala Phe Ile Thr Val Glu Ser Phe Leu 100 105 110 Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val Ala Val Cys Arg Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Thr Thr Val Met Cys Ala Ser Leu Val Met 130 135 140 Gly Cys Tyr Ile Cys Gly Phe Leu Asn Ala Ser Ile His Thr Gly Asn 145 150 155 160 Ile Phe Arg Leu Ser Phe Cys Arg Ala Ser Val Val Asp His Phe Phe 165 170 175 Cys Asp Ala Pro Pro Leu Leu Ala Leu Ser Cys Ser Asp Asn Tyr Ile 180 185 190 Ser Glu Met Val Ile Phe Leu Val Val Gly Met Asn Asn Leu Phe Ser 195 200 205 Val Leu Val Ile Leu Ile Ser Tyr Leu Phe Ile Phe Ile Thr Ile Leu 210 215 220 Arg Met Arg Ser Ser Glu Gly Arg Gln Lys Ala Phe Ser Thr Cys Thr 225 230 235 240

Page 3467

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Ser His Leu Thr Thr 245 Val Ser Ile Tyr Leu Gln Pro 260 Ser Ala Asn His Ser Val Phe 275 Tyr Thr Met Val Ile 280 Ser Leu 290 Arg Asn Lys Glu Val 295 Lys Lys 305 Ala Lys Ser Ser Ile 310 Gly Phe

Ile Phe

Phe Tyr Gly Thr Gly Thr Phe Met 250 255 Ser Met Asp Thr Asp Lys Val Ala 265 270 Pro Met Leu Asn Pro Val Val Tyr 285 Ser Ala Phe Lys Lys Ala Ile Gly

300 <210> 3107 <211> 950 <212> DNA <213> Felis catus <400> 3107 ctacttccta ctcacactta acgacggagg attttttacc tctttgttcc taaggctgta cgagtaaaac acagaagcaa ttttgtccgt atacatgaag atgatggttc catagaagat agagaaggct ttcttccgtc cttccgcaga gaagtaagag atgaggatga ccaggagggt gacagccaag ctgctgatgc gagtgtcaga gcagaagaaa tgatttactt cgtgagagcc gtgaatggag gcattgagga agccacagac acctgccgtc atggtggtgg agtaatggag ggccatggag gccaggaggt agcactcgac agcagcacat ccattgtagg tgatgacttt acaaagttgg ttgcgtattt tccagagagc gatcaagggg ttcagcatgg gaatcaccac gtccattgac tcgctggagc tgggctgtaa ggtgacagca gtgaggtggg aggcacaggt acgcatcctt tgaatggcga tgtatatgaa gaagaagacg ttgaagccca cgacacagaa acacgagaga gttaagagtg gcggaatgtc acagaatgag agtctaaagg tgtttgccgt ataggagcca gcagtcagga gggcacacac tggcctacac acagctgcat ggcggtcata agtggcaaaa cccgcgaaga agaagaactg gctccctgaa tgcagtgcag ccaccatctt

120

180

240

300

360

420

480

540

600

660

720

Page 3468

069269_0225_SL.TXT aggagctacc gctgacgagt aacccaggtc tacgaaggag aggttactga attggagtgt ggaggtgggg gtctgcgcgg atgattgcca tcatcccccc agagtgatga ggtagatgaa taaaaatacc aggaggaggg ggacctgaag tctgttaatc ccaagaggat gaactctgtt gcttctgtgc cattctccat ggaaaaatac attcccaacc atgagggtcg

780

840

900

950 <210> 3108 <211> 315 <212> PRT <213> Felis catus <400> 3108

Gly 1 Glu Trp His Arg 5 Ser Asn Arg Pro Ser Ser 20 Ser Gly Pro Pro His His 35 Ser Gly Trp Glu Arg Pro 50 Pro Pro Pro His Ser 55 Phe 65 Val Asp Leu Gly Tyr 70 Ser Ala Leu His Ser Gly 85 Ser Lys Gln Phe Phe Phe 100 Phe Ala Gly Ala Ser Met 115 Ala Tyr Asp Arg Tyr Ser 130 Thr Thr Met Thr Ala 135 Ser Tyr Val Cys Gly Phe Leu

Arg Val His 10 Pro Leu Gly Ile Pro Pro 25 Pro Gly Ile Phe Ile 30 Trp 40 Gly Asp Asp Gly Asn 45 His Asn Val Phe Phe Leu 60 Ser Asn Ser Ala Val Ala 75 Pro Lys Met Val Ile Thr 90 Tyr Asn Gly Cys Phe Ala 105 Thr Val Glu Cys Tyr 110 His 120 Ala Ala Val Cys Arg 125 Pro Gly Val Cys Ala Leu 140 Leu Thr Asn Ala Ser Page Ile His 3469 Thr Ala

Asn Arg 15

His Leu

Pro Arg

Leu Ser

Val Ala 80

Ala Ala 95

Leu Leu

Leu His

Ala Gly

Asn Thr

0 6926 9_02 25_S L.TX T 145 150 155 160 Phe Arg Leu Ser Phe Cys Gly Ser His Glu Val Asn His Phe Phe Cys 165 170 175 Asp Ile Pro Pro Leu Leu Thr Leu Ser Cys Ser Asp Thr Arg Ile Ser 180 185 190 Ser Leu Ala Val Phe Cys Val Val Gly Phe Asn Val Phe Phe Thr Leu 195 200 205 Leu Val Ile Leu Ile Ser Tyr Phe Phe Ile Tyr Ile Ala Ile Gln Arg 210 215 220 Met Arg Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Ala Ser 225 230 235 240 His Leu Thr Ala Val Thr Ile Phe Tyr Gly Thr Ile Ile Phe Met Tyr 245 250 255 Leu Gln Pro Ser Ser Ser Glu Ser Met Asp Thr Asp Lys Ile Ala Ser 260 265 270 Val Phe Tyr Ser Val Val Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser 275 280 285 Leu Arg Asn Lys Glu Val Lys Asn Ala Leu Trp Lys Ile Arg Asn Gln 290 295 300 Leu Cys Pro Pro Ser Leu Ser Val Ser Arg Lys 305 310 315

<210> 3109 <211> 958 <212> DNA <213> Felis catus <400> 3109 gaaccataag acacagaggg aacatctgct tcttctggtt cttgagtttt ttcaatgcat 60 ctttgatctc cttgtttcgc aaactgtata tgatgggatt cagcatggga atcacagctc 120

Page 3470

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catagagcat ggacaccacc ttctcttggt cctgtgagta gccagcacta gaatggagat 180 atgagaagag accagagcca tagaagagaa tcactgtggt cagatgagag gcacaggtgt 240 tgaaagcctt catccgccct tgggttgaat ggatcttcat gacagcagca atgatgtagc 300 aataggacac caggacaaca agagctgatg tcccaccaac tgcacacaca acaagaaagt 360 tcactacctg gctgaggaag gtactagaac aagacaagac tagcagaggt ggcaggtcac 420 agaaaaagtg tttaatgact cgtggaccac agaaatacag ctggaatatg gagctggttt 480 ggaccaatcc cgtgaggaac cctccagtgt atgctgtaat gaccatcccc acacacatgg 540 tgggtgacat gaaggctgcg tagaacagag gggtggaaat agcagcatag cggtcatatg 600 ccatggccgc caggagacag cattcagtgg cccccatgct gatgaagaag aaaaactgag 660 tagcacatcc cacaaaggag atggtcttct gctgcttgaa gaagtcacag agcatcttgg 720 gggtgatgga ggacgtgtat gagatgtcaa caaaggacaa gtttccaagg aagaaataca 780 tgggggagtg caggcatgac tccatcctga tcaagacaac aaggcccagg ttccaagtca 840 gagtcacaga atagatcccc agaaacaaca caaagaggaa agcctgaagc tctggctgct 900 ctgaaaatcc caaaaggatg aagtcggttg ttatgttgat gttccttccc atggccat 958

<210> 3110 <211> 320 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (320)..(320) <223> Any amino acid

<400> 3110 Asn Ile Asn Ile Thr Thr Asp Phe Ile Leu Leu Met 1 Ala Met Gly Arg 5 10 15 Gly Phe Ser Glu Gln Pro Glu Leu Gln Ala Phe Leu Phe Val Leu Phe 20 25 30 Leu Gly Ile Tyr Ser Val Thr Leu Thr Trp Asn Leu Gly Leu Val Val 35 40 45

Page 3471

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Leu Ile Arg Met Glu Ser Cys Leu His Ser Pro Met Tyr Phe Phe Leu 60 50 55 Gly Asn Leu Ser Phe Val Asp Ile Ser Tyr Thr Ser Ser Ile Thr Pro 65 70 75 80 Lys Met Leu Cys Asp Phe Phe Lys Gln Gln Lys Thr Ile Ser Phe Val 85 90 95 Gly Cys Ala Thr Gln Phe Phe Phe Phe Ile Ser Met Gly Ala Thr Glu 100 105 110 Cys Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Ser 115 120 125 Thr Pro Leu Phe Tyr Ala Ala Phe Met Ser Pro Thr Met Cys Val Gly 130 135 140 Met Val Ile Thr Ala Tyr Thr Gly Gly Phe Leu Thr Gly Leu Val Gln 145 150 155 160 Thr Ser Ser Ile Phe Gln Leu Tyr Phe Cys Gly Pro Arg Val Ile Lys 165 170 175 His Phe Phe Cys Asp Leu Pro Pro Leu Leu Val Leu Ser Cys Ser Ser 180 185 190 Thr Phe Leu Ser Gln Val Val Asn Phe Leu Val Val Cys Ala Val Gly 195 200 205 Gly Thr Ser Ala Leu Val Val Leu Val Ser Tyr Cys Tyr Ile Ile Ala 210 215 220 Ala Val Met Lys Ile His Ser Thr Gln Gly Arg Met Lys Ala Phe Asn 225 230 235 240 Thr Cys Ala Ser His Leu Thr Thr Val Ile Leu Phe Tyr Gly Ser Gly 245 250 255

Page 3472

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Leu Phe Ser Tyr Leu His Ser Ser Ala Gly Tyr Ser Gln Asp Gln Glu 260 265 270

Lys Val Val Ser Met Leu Tyr Gly Ala Val Ile Pro Met Leu Asn Pro 275 280 285

Ile Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Lys Lys 290 295 300

Leu Lys Asn Gln Lys Lys Gln Met Phe Pro Leu Cys Leu Met Val Xaa 305 310 315 320 <210> 3111 <211> 954 <212> DNA <213> Felis catus <400> 3111 agacctttaa ctatgacaat gggaaaaagc gatttccttg ttcctcagac tgtaaatcaa gaagactgat gccatcttgt catggtccag aaagagtcct gatccaaaaa aacagatcac ggccttggac ctgcctttag cagagcttgt agatatcatg atgactgaga cagatattac gacttttagg aaagaggttt cagagcagga gaagtggttg ataacattgg gcccacaaaa caatgaacca aagagagcag ttatacaggc tgacacgatg gcggtgtaga gtagaggatt ggcggccagg agacagcact cagtcagacc gcatcccaga aaggagatgg atttaggctt tgtggaggta acatagcaga aatccaagaa tgtatgtagg tgagagtcca tcttaatcag tctcttctta aggattcaac agaatcatca tgctgtcagg cttcaggatg accaaaaatc taggactaat attgagctga tccaaccatc acaaatggca caggctagag ctggaagaag agataagtta gatgatgagg

cacctcttaa aggcgtcttt 60 atggggatca ccactgtata 120 gtgctggggt gcatatagac 180 tgagaagtac aggtattgaa 240 gtagcaatga tataaccata 300 actgctatca caaacttcat 360 aattgaggca ggtcacagaa 420 agtaaagcac acaattggat 480 atctgtacac agagggtggg 540 gcatatcggt cataagccat 600 aagaagaagt actgcatggt 660 tctgagagca ttttcggggt 720 ctgaggaaga agtacatggg 780 cccaggttcc aagccactgt 840

Page 3473

900

954

069269_0225_SL.TXT caagaggtaa gaacccaaga atactacaaa gagagcgatc ttgatcttgg gataatctga gaatcccaaa aggatgaatc tgatgactat tgtactgttc cttcctccag ccat <210> 3112 <211> 315 <212> PRT <213> Felis catus <400> 3112

Met Ala Gly Gly Arg Asn Ser Thr Ile Val Ile Arg Phe Ile Leu Leu 1 5 10 15 Gly Phe Ser Asp Tyr Pro Lys Ile Lys Ile Ala Leu Phe Val Val Phe 20 25 30 Leu Gly Ser Tyr Leu Leu Thr Val Ala Trp Asn Leu Gly Leu Ile Ile 35 40 45 Leu Ile Lys Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Phe Leu Asp Phe Cys Tyr Val Thr Ser Thr Thr Pro 65 70 75 80 Lys Met Leu Ser Asp Phe Phe Gln Lys Pro Lys Ser Ile Ser Phe Leu 85 90 95 Gly Cys Thr Met Gln Tyr Phe Phe Phe Ser Ser Leu Gly Leu Thr Glu 100 105 110 Cys Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Thr Ala Ile Val Ser Pro Thr Leu Cys Val Gln 130 135 140 Met Met Val Gly Ala Cys Ile Thr Ala Leu Phe Gly Ser Leu Ile Gln 145 150 155 160 Leu Cys Ala Leu Leu Gln Leu Asn Phe Cys Gly Pro Asn Val Ile Asn

Page 3474

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165 170 175

His Phe Phe Cys Asp Leu Pro Gln Leu Leu Val Leu Ser Cys Ser Glu 180 185 190 Thr Ser Phe Leu Lys Val Met Lys Phe Val Ile Ala Val Ile Phe Gly 195 200 205 Val Ile Ser Val Ser Val Ile Met Ile Ser Tyr Gly Tyr Ile Ile Ala 210 215 220 Thr Ile Leu Lys Thr Ser Ser Ala Lys Gly Arg Ser Lys Ala Phe Asn 225 230 235 240 Thr Cys Thr Ser His Leu Thr Ala Val Ile Cys Phe Phe Gly Ser Gly 245 250 255 Leu Phe Val Tyr Met His Pro Ser Thr Asp Asp Ser Leu Asp His Asp 260 265 270 Lys Met Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Phe Lys Arg 290 295 300 Cys Lys Lys Arg Ala Phe Ser His Cys His Ser

305 310 315 <210> 3113 <211> 976 <212> DNA <213> Felis catus <400> 3113 ctatactgta catttgaaat aaattccata attagttaaa acagaaaaag attctcttct tccttctgtt tagggcatct ttgatttcct tgttcctcaa gctatagatc aatggattta gcatggggat taaaacagtg tataaaactg atgccaactt gttttggctc agggaatcac cagagttagg atacatataa acaaagatac ctgagccaaa gaagagagcc acagctgtca

120

180

240

Page 3475

069269_0225_SL.TXT ggtgagaagc acaggtgttg aaggccttgg acctgccttc agctgaggtg atcttcagaa tggtggcaac aatataaccg taggatatca tgataaccaa gacagatgtg agcccaaaga tcactgtgag cacagaggtc atgatttgaa agaaaaaggt gtcagagcag gataggatca gcaactgggg aagatcacaa aagaaatggt tgatgacatt tggcccacag aaatgaagct gaagtaaggc atacagttgg ataaatgagc cacagaatcc aattacacaa gatcccccca ccatctgcac acagagggtg ggcaacatga tggcggtgta gagcagagga ttacaaatgg cagcatatcg gtcataagcc atggcggcca ggagacagca ctcagtcaga cccaggctag agaagaagaa gtactgtata gtgcacccca caaaggagat gtatttctgc ttcttgaaga aatctgagag catcttgggc gctatagtgg aaacatagca gatgtccagc agggacaggt tactgaggaa aaagtacata ggtgtgtgca gatgtgagtc caccctgatg agagtgatga ggcctaggtt ccaggacaca gtcatgaggt agatcgctag gaatattgaa aaaagaacac tggcgagctt tggaaattca gagaatccca agagaatgaa ctttgtaact attgtactgt tccttccccc agccat <210> 3114 <211> 314 <212> PRT <213> Felis catus

300

360

420

480

540

600

660

720

780

840

900

960

976

<400> 3114 Met Ala Gly Gly 1 Arg 5 Asn Ser Thr Ile Val Thr Lys Phe Ile Leu Leu 10 15 Gly Phe Ser Glu Phe Pro Lys Leu Ala Ser Val Leu Phe Ser Ile Phe 20 25 30 Leu Ala Ile Tyr Leu Met Thr Val Ser Trp Asn Leu Gly Leu Ile Thr 35 40 45 Leu Ile Arg Val Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Leu Leu Asp Ile Cys Tyr Val Ser Thr Ile Ala Pro 65 70 75 80

Page 3476

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Lys Met Leu Ser Asp Phe 85 Phe Lys Lys Gln Lys Tyr Ile Ser Phe Val 90 95 Gly Cys Thr Ile Gln Tyr Phe Phe Phe Ser Ser Leu Gly Leu Thr Glu 100 105 110 Cys Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys 115 120 125 Asn Pro Leu Leu Tyr Thr Ala Ile Met Leu Pro Thr Leu Cys Val Gln 130 135 140 Met Val Gly Gly Ser Cys Val Ile Gly Phe Cys Gly Ser Phe Ile Gln 145 150 155 160 Leu Tyr Ala Leu Leu Gln Leu His Phe Cys Gly Pro Asn Val Ile Asn 165 170 175 His Phe Phe Cys Asp Leu Pro Gln Leu Leu Ile Leu Ser Cys Ser Asp 180 185 190 Thr Phe Phe Phe Gln Ile Met Thr Ser Val Leu Thr Val Ile Phe Gly 195 200 205 Leu Thr Ser Val Leu Val Ile Met Ile Ser Tyr Gly Tyr Ile Val Ala 210 215 220 Thr Ile Leu Lys Ile Thr Ser Ala Glu Gly Arg Ser Lys Ala Phe Asn 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Val Ala Leu Phe Phe Gly Ser Gly 245 250 255 Ile Phe Val Tyr Met Tyr Pro Asn Ser Gly Asp Ser Leu Ser Gln Asn 260 265 270 Lys Leu Ala Ser Val Leu Tyr Thr Val Leu Ile Pro Met Leu Asn Pro 275 280 285

Page 3477

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Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Asn Arg 290 295 300

Arg Lys Lys Arg Ile Phe Phe Cys Phe Asn

305 310 <210> 3115 <211> 899 <212> DNA <213> Felis catus <400> 3115 tgaaaatatt ctcttttccc atctatttaa ggcatctttg atttccgtgt tccttaggtt 60 tcagatcaat agatttaaat caccacagtg tatacaacag agtgttttgg ctcagaaaat 120 catcagaagt agggcacaaa tagaccaagg tgcgtgagcc ataaaagaga gtcacagcta 180 tccggtgaga agcacagaag ttgaaggcct tggacctgcc ttcagatgaa gtgatctcag 240 aatggtggca gcaatataac catagaatat catgataacc aagacagatg tgagtccaaa 300 gatcactgtg agcacagagg tcccgatttg aaaggaaaag gtgtcagagc agaatatgat 360 cagcagctgg ggaaaatcac aaaagaaatg gctgatgaca tttggcccac agaaatgaag 420 ctgaaataag gcacacagtt ggataaatga gccaaagaat ccagttacac gagatctcac 480 aaccatctgc acacagaggg tgggagatat gatggtggtg tagaacagag gcttacaaat 540 ggcagcatat cggtcacaag ccatagctgc taagaaaaag cgctcagtca gactcggtaa 600 agaagaagta ctgcatggtg ccccctacaa aggagatgta tttctgcttc ttgaagaaat 660 ctgagagcgt cttggaagct gtggaggaaa cataacaaat atctaagaag gcaagtttat 720 tgataaagaa atacatgggt gtgtgcaggt aggagtccat cttgatcaga gtgatgaggt 780 tgacattgca gaacactgtc acgagggaga tgcctaggaa aaaggatgac ttcaagtgtt 840 ggaaattcag agtatcccaa taggataaac ctggtaattg tagtgctgtt tcttccttc 899 <210> 3116 <211> 104 <212> PRT <213> Felis catus

Page 3478

069269_0225_SL.TXT <400> 3116

Lys Glu Glu Thr Ala Leu Gln Leu Pro Gly Leu Ser Tyr Trp Asp Thr 1 5 10 15 Leu Asn Phe Gln His Leu Lys Ser Ser Phe Phe Leu Gly Ile Ser Leu 20 25 30 Val Thr Val Phe Cys Asn Val Asn Leu Ile Thr Leu Ile Lys Met Asp 35 40 45 Ser Tyr Leu His Thr Pro Met Tyr Phe Phe Ile Asn Lys Leu Ala Phe 50 55 60 Leu Asp Ile Cys Tyr Val Ser Ser Thr Ala Ser Lys Thr Leu Ser Asp 65 70 75 80 Phe Phe Lys Lys Gln Lys Tyr Ile Ser Phe Val Gly Gly Thr Met Gln 85 90 95 Tyr Phe Phe Phe Thr Glu Ser Asp

100 <210> 3117 <211> 939 <212> DNA <213> Felis catus <400> 3117

tcagcagtac catctcttct tctgtaaact cctcaaggca tctttgattt ccttgttcct 60 cagactgtaa atcaaaggat tcaacatggg gataaccaca gtgtagaata ctgatgcaaa 120 tctgtcaaaa ctggaggaac cgccagagct ggaactcaaa tagacaaaga cactcgagat 180 ataaaagagg gaaactgctg ttagatgaga agcacaggtg ttgaaagcct tggacctgcc 240 tttagctgaa gtgatcttca tgacggagat gacaatataa cagtaggata ccatgataat 300 gagagcatta actaccccaa agatcattgt tactatagca agcaatagct gtacaaagaa 360 agtgtcagtg caggacagga ctaacaactg gggcatgtca cagaagaagt ggttgatgac 420 attaggccca cagaagtgaa gctgaagtat ggcacacaat tgggatacag aaccagagag 480 tccagccaga taggacccca gcaccatccg aatacacagg gtgggtgaca tgactgatga 540

Page 3479

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atagagaaga ggattacaaa tggcggcata tcggtcataa gccatggctg tcatgagaca 600 agactcactc agtcccatga ttgaaaaaac aaagtattga acggcgcaac ccacaaaggt 660 gatagtctgc tgctcttgga aaaagctgga gagcatcttg ggggctgtgg aggtcacata 720 gcagatatcc atgaaggaca gattactgag gaagaagtac atgggtgtgt ggaggtgaga 780 gtccatcctt attaagatga tgaggcacaa gttccaagtc agagtcataa tgtagatgag 840 caggaataca acaaagagca ctactaggat tctggggaaa tcagagaatc ccaaaaggat 900 gaaataagtg acctctgtaa tatttcctcc cccagtcat 939

<210> 3118 <211> 312 <212> PRT <213> Felis catus

<400> 3118 Asn Ile Thr Glu Val Thr Tyr Phe Ile Leu Leu Met 1 Thr Gly Gly Gly 5 10 15 Gly Phe Ser Asp Phe Pro Arg Ile Leu Val Val Leu Phe Val Val Phe 20 25 30 Leu Leu Ile Tyr Ile Met Thr Leu Thr Trp Asn Leu Cys Leu Ile Ile 35 40 45 Leu Ile Arg Met Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Asn Leu Ser Phe Met Asp Ile Cys Tyr Val Thr Ser Thr Ala Pro 65 70 75 80 Lys Met Leu Ser Ser Phe Phe Gln Glu Gln Gln Thr Ile Thr Phe Val 85 90 95 Gly Cys Ala Val Gln Tyr Phe Val Phe Ser Ile Met Gly Leu Ser Glu 100 105 110 Ser Cys Leu Met Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys 115 120 125

Page 3480

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Asn Pro 130 Leu Leu Tyr Ser Ser Val Met Ser Pro Thr Leu Cys Ile Arg 135 140 Met Val Leu Gly Ser Tyr Leu Ala Gly Leu Ser Gly Ser Val Ser Gln 145 150 155 160 Leu Cys Ala Ile Leu Gln Leu His Phe Cys Gly Pro Asn Val Ile Asn 165 170 175 His Phe Phe Cys Asp Met Pro Gln Leu Leu Val Leu Ser Cys Thr Asp 180 185 190 Thr Phe Phe Val Gln Leu Leu Leu Ala Ile Val Thr Met Ile Phe Gly 195 200 205 Val Val Asn Ala Leu Ile Ile Met Val Ser Tyr Cys Tyr Ile Val Ile 210 215 220 Ser Val Met Lys Ile Thr Ser Ala Lys Gly Arg Ser Lys Ala Phe Asn 225 230 235 240 Thr Cys Ala Ser His Leu Thr Ala Val Ser Leu Phe Tyr Ile Ser Ser 245 250 255 Val Phe Val Tyr Leu Ser Ser Ser Ser Gly Gly Ser Ser Ser Phe Asp 260 265 270 Arg Phe Ala Ser Val Phe Tyr Thr Val Val Ile Pro Met Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Leu Arg Asn Lys Glu Ile Lys Asp Ala Leu Arg Ser 290 295 300 Leu Gln Lys Lys Arg Trp Tyr Cys

305 310 <210> 3119 <211> 959

Page 3481

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 3119 atgtccacag ctaaggcctg gaatagctct tcagtaacca tgttcatctt cctgggattt 60 gcagaccatc cagaactcca gacccttctc tttgtgacct tcctgggtat ctatcttgtg 120 acactggcct ggaacctggc cctcatcttt ttgatcagag gtgacccccg tctgcacaca 180 cccatgtact tcttcctcag caacttgtct ttcatcgaca tctgctactc ttctacagtg 240 gcccccaaga tgctcactga tttcttctgg gagcaaaaga ccatatcatt cttgggctgt 300 gctgctcagt tttttttctt tgtcagtatg ggtctcactg agtgcttcct cctgactgcc 360 atggcatacg acagatacgc agccatctcc aatcccctgc tgtacacagc catcatgtcc 420 caaggcctct gcacacgcat ggtgcttggg gcatatgttg gtggcttcct gagctccctg 480 atccaggcca gctccatatt tcagcttcac ttctgcggac ccaacattat caatcatttc 540 ttctgtgacc tccctccagt actggcactt tcttgctctg acacctttcc tagtcaagtg 600 gtgaattttc tcgtggtagt cactattggg gggacatcat tcctcatcct catcatctcc 660 tacagttaca taggaactgc tgtcttgaaa atccgttcag tggaaggccg aaagaaagcc 720 ttcagcacat gtgcctcaca cttgatggtg gtgactctgt tgtttgggac ggcccttttc 780 atgtacctga gacccagctc cagctactcg cttggcaggg acaaggtagt gtctgtgttc 840 tattcactgg tgatccccat gctgaaccct cttatttaca gtttgaggaa cagagagatc 900 aaagatgccc tatggaaggt gttggagaag aagaaactgt tttcctagtt cacgattga 959 <210> 3120 <211> 315 <212> PRT <213> Felis catus

<400> 3120 Met Ser Thr Ala Lys Ala Trp Asn Ser Ser Ser Val Thr Met Phe Ile 1 5 10 15 Phe Leu Gly Phe Ala Asp His Pro Glu Leu Gln Thr Leu Leu Phe Val 20 25 30 Thr Phe Leu Gly Ile Tyr Leu Val Thr Leu Ala Trp Asn Leu Ala Leu Page 348 2

069269_0225_SL.TXT 40 45

Ile Phe Leu Ile Arg Gly Asp Pro Arg Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Ser Asn Leu Ser Phe Ile Asp Ile Cys Tyr Ser Ser Thr Val 65 70 75 80 Ala Pro Lys Met Leu Thr Asp Phe Phe Trp Glu Gln Lys Thr Ile Ser 85 90 95 Phe Leu Gly Cys Ala Ala Gln Phe Phe Phe Phe Val Ser Met Gly Leu 100 105 110 Thr Glu Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Ala Ala 115 120 125 Ile Ser Asn Pro Leu Leu Tyr Thr Ala Ile Met Ser Gln Gly Leu Cys 130 135 140 Thr Arg Met Val Leu Gly Ala Tyr Val Gly Gly Phe Leu Ser Ser Leu 145 150 155 160 Ile Gln Ala Ser Ser Ile Phe Gln Leu His Phe Cys Gly Pro Asn Ile 165 170 175 Ile Asn His Phe Phe Cys Asp Leu Pro Pro Val Leu Ala Leu Ser Cys 180 185 190 Ser Asp Thr Phe Pro Ser Gln Val Val Asn Phe Leu Val Val Val Thr 195 200 205 Ile Gly Gly Thr Ser Phe Leu Ile Leu Ile Ile Ser Tyr Ser Tyr Ile 210 215 220 Gly Thr Ala Val Leu Lys Ile Arg Ser Val Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Ala Ser His Leu Met Val Val Thr Leu Leu Phe Gly

Page 3483

069269_0225_SL.TXT

245 250 255

Thr Ala Leu Phe Met Tyr Leu Arg Pro 265 Ser Ser Ser Tyr Ser 270 Leu Gly 260 Arg Asp Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Arg Glu Ile Lys Asp Ala Leu 290 295 300 Trp Lys Val Leu Glu Lys Lys Lys Leu Phe Ser 305 310 315

<210> 3121 <211> 966 <212> DNA <213> Felis catus <400> 3121 atggaggagg gtggtcccaa ccatggccag agcaaccaca ccaatgtgaa ggaatttgtc ttcctagaac tcactcactt ccaggagctg gaatgtttct tgtttgtggc tttccttgct gtatatgtaa ccaccgtgct gggcaatgcc ctcattgtgc tgaccatcac ctatgagtcc caccttcaca ctcccatgta ctttctgctg cggaacaaat cggtcctgga cattgttttt tcatctgtca ctgttcccaa gttcctggtg gatctgttat cagagaggaa aaccatctcc tacaatggct gcatggcaca gatcttcttc ttccattttg ctggtggggc agatattttc ttcctctccg tgatggccta tgacagatac cttgcaatcg ccaaacccct gcattatgtg accattatga agagagaggt gtgggtgggc ttggtggtgg cttcctgggt gggcggtggt ttgcactcaa ttgtccagat aattctgatg cttccactct ccttctgtgg ccccaacatc ctggatgcct tctactgtga tgtgccccaa gtagttaagc tggcttgcac tgataccttt gctctggaac ttctcatgat ctctaacaat gggttggtga ccctgctatg gttcctcttg ctcctgggat cctacaccgt tattctggtg atgctgagat ctcactctgg ggcaggacgg aacaaggccc tgtccacctg cacctcccat atcctcgtgg tgactctgca ctttgtgcct tgtgtctaca tctactgccg gcccttcact acactgccca tggacacagc tgtgtccatc

120

180

240

300

360

420

480

540

600

660

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780

840

Page 3484

069269_0225_SL.TXT aataacacgg tcattacgcc catgctgaac cccatgattt ataccctgag gaaccaggag atgaagtctg ccatgaaaag actacacaga aggcttggac cttctgagag cagtaagctg gggtga

900

960

966 <210> 3122 <211> 321 <212> PRT <213> Felis catus

<400> 3122 Pro Asn His Gly Gln Ser Asn His Thr Asn Val Met Glu 1 Glu Gly Gly 5 10 15 Lys Glu Phe Val Phe Leu Glu Leu Thr His Phe Gln Glu Leu Glu Cys 20 25 30 Phe Leu Phe Val Ala Phe Leu Ala Val Tyr Val Thr Thr Val Leu Gly 35 40 45 Asn Ala Leu Ile Val Leu Thr Ile Thr Tyr Glu Ser His Leu His Thr 50 55 60 Pro Met Tyr Phe Leu Leu Arg Asn Lys Ser Val Leu Asp Ile Val Phe 65 70 75 80 Ser Ser Val Thr Val Pro Lys Phe Leu Val Asp Leu Leu Ser Glu Arg 85 90 95 Lys Thr Ile Ser Tyr Asn Gly Cys Met Ala Gln Ile Phe Phe Phe His 100 105 110 Phe Ala Gly Gly Ala Asp Ile Phe Phe Leu Ser Val Met Ala Tyr Asp 115 120 125 Arg Tyr Leu Ala Ile Ala Lys Pro Leu His Tyr Val Thr Ile Met Lys 130 135 140 Arg Glu Val Trp Val Gly Leu Val Val Ala Ser Trp Val Gly Gly Gly 145 150 155 160

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069269_0225_SL.TXT

Leu His Ser Ile Val Gln Ile Ile Leu Met Leu Pro Leu Ser Phe 175 Cys 165 170 Gly Pro Asn Ile Leu Asp Ala Phe Tyr Cys Asp Val Pro Gln Val Val 180 185 190 Lys Leu Ala Cys Thr Asp Thr Phe Ala Leu Glu Leu Leu Met Ile Ser 195 200 205 Asn Asn Gly Leu Val Thr Leu Leu Trp Phe Leu Leu Leu Leu Gly Ser 210 215 220 Tyr Thr Val Ile Leu Val Met Leu Arg Ser His Ser Gly Ala Gly Arg 225 230 235 240 Asn Lys Ala Leu Ser Thr Cys Thr Ser His Ile Leu Val Val Thr Leu 245 250 255 His Phe Val Pro Cys Val Tyr Ile Tyr Cys Arg Pro Phe Thr Thr Leu 260 265 270 Pro Met Asp Thr Ala Val Ser Ile Asn Asn Thr Val Ile Thr Pro Met 275 280 285 Leu Asn Pro Met Ile Tyr Thr Leu Arg Asn Gln Glu Met Lys Ser Ala 290 295 300 Met Lys Arg Leu His Arg Arg Leu Gly Pro Ser Glu Ser Ser Lys Leu 305 310 315 320

Gly <210> 3123 <211> 930 <212> DNA <213> Felis catus <400> 3123

Page 3486

069269_0225_SL.TXT atggccctga gaaattatac caaggtgtct gaatttattt tttgtggact tacccagtct 60 caagagctga gcttgctctt atttttcttt ttatctgtag tttatgtaac aactgtgtta 120 gcaaatgttg ccatcatggt cactgtgacc tacgagtccc gccttcacac gcccatgtac 180 ttcctgctcc gcaatctctc cgtcttggac atctgcttct cctccatcac cgctcccaag 240 gtcctcgtag acctcctgtc aaggacgaag accatctcct tcaatggttg catcactcag 300 atcttcttct tccacctcct cgggggggca gacatttttt ctctctctgt catggccttc 360 gaccgctaca tggccatctc caagcccctg cactacgtga ccatcatgag cagggggcga 420 tgcactgccc tcatcgtggc ctcctgggtg gggggctttg tccactccat cgtgcagatt 480 tccctgttgc tgcccctccc tttctgtgga cccaatgttg ttgatggctt ctactgcgac 540 gtcccccagg tcctcaaact cgcctgcacc aacacctttg ctcttgaggt cttaatgatt 600 tccaacaatg gtctagtcac tactttgtgg tttgttcttc tccttgtgtc ctacacagtc 660 atcttgatga tgctgagatc tcacgctggg gagggaagga ggaaagccat ctccacctgc 720 accgcccaca tcactgtggt gaccctgcac tttgtgccct gcatctatgt ctacgcccgg 780 cccttcaccg cccttcccat ggacagagct gtctccatca ccttcacggt catcatcccg 840 gtcctgaacc ccatgatcta caccctcagg aaccaggaga tgaagtcagc catgaagaga 900 ttgaagggaa gacttatgtt ttctgaaagg 930 <210> 3124 <211> 310 <212> PRT <213> Felis catus

<400> 3124 Met 1 Ala Leu Arg Asn Tyr Thr Lys Val Ser Glu Phe Ile Phe Cys Gly 5 10 15 Leu Thr Gln Ser Gln Glu Leu Ser Leu Leu Leu Phe Phe Phe Leu Ser 20 25 30 Val Val Tyr Val Thr Thr Val Leu Ala Asn Val Ala Ile Met Val Thr 35 40 45 Val Thr Tyr Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg Page 3487

069269_0225_SL.TXT

50 55 60 Asn Leu Ser Val Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Val Leu Val Asp Leu Leu Ser Arg Thr Lys Thr Ile Ser Phe Asn Gly 85 90 95 Cys Ile Thr Gln Ile Phe Phe Phe His Leu Leu Gly Gly Ala Asp Ile 100 105 110 Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Met Ala Ile Ser Lys 115 120 125 Pro Leu His Tyr Val Thr Ile Met Ser Arg Gly Arg Cys Thr Ala Leu 130 135 140 Ile Val Ala Ser Trp Val Gly Gly Phe Val His Ser Ile Val Gln Ile 145 150 155 160 Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Val Asp Gly 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Asn Thr 180 185 190 Phe Ala Leu Glu Val Leu Met Ile Ser Asn Asn Gly Leu Val Thr Thr 195 200 205 Leu Trp Phe Val Leu Leu Leu Val Ser Tyr Thr Val Ile Leu Met Met 210 215 220 Leu Arg Ser His Ala Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 225 230 235 240 Thr Ala His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Met Asp Arg Ala Val Ser

Page 3488

260

069269_0225_SL.TXT 265 270

Ile Thr Phe Thr Val Ile Ile Pro Val Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Lys Ser Ala Met Lys Arg Leu Lys Gly Arg 290 295 300 Leu Met Phe Ser Glu Arg 305 310

<210> 3125 <211> 936 <212> DNA <213> Felis catus <400> 3125 atggagctga gaaactgcac cagggtgaaa gaatttactt tccttggtct aacccagaat 60 caagagctga gcttggtctt atttcttttc ctgcttctcg tgtacgtgac aactctgctg 120 ggaaacctcc tcatcatggt cactgtgtcc tgtgaatctc gccttcacac ccccatgtac 180 ttcctgctcc gtaatttatc tattgccgac atctgctttt cctccatcac tgctcccaag 240 gttctggtgg acctgctgtc acagagaaag accatctcct tcaatggctg cttcacccag 300 atgtttttct tccaccttgt cggaggggtg gatgtgtttt cattatcagt gatggcattg 360 gatcgatatg tggccatctc caagcctctg cactacgtga ccatcatgag tagaggtcgt 420 tgcattggat tcatagtggc ctcctgggtg gggggctttg tccactccat tgtgcagatt 480 tccctgttgg ttccactccc gttctgtgga cccaatgttc ttgacacttt ctactgtgat 540 gtcccccagg ttctcaagct ctcctgtaca gacattttta tacttgagtt gctgatgatt 600 tccaataatg gactgctcac cacactgtgg ttcttcttcc tcttggtgtc atatatggtc 660 atattattag tagtaaggtc tcaggcaggg gaggggagga ggaaagccat ctccacctgc 720 acctcccaca tcactgtggt gaccctgcac tttgtgccct gcatctacgt ctatgcccgg 780 cccttcactg ccctccccac agataaagcc atctctgtca ccttcactgt catctccccg 840 ctgctgaacc ccttgatcta cacgctgagg aaccaggaga tgaagtcagc catgaggaga 900 ctgaagagaa gactcatgcc ttctgacagg gaatag 936

Page 3489

069269_0225_SL.TXT <210> 3126 <211> 311 <212> PRT <213> Felis catus

<400> 3126 Met 1 Glu Leu Arg Asn 5 Cys Thr Arg Val Lys Glu Phe Thr Phe Leu Gly 10 15 Leu Thr Gln Asn Gln Glu Leu Ser Leu Val Leu Phe Leu Phe Leu Leu 20 25 30 Leu Val Tyr Val Thr Thr Leu Leu Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Ser Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ser Ile Ala Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Val Leu Val Asp Leu Leu Ser Gln Arg Lys Thr Ile Ser Phe Asn Gly 85 90 95 Cys Phe Thr Gln Met Phe Phe Phe His Leu Val Gly Gly Val Asp Val 100 105 110 Phe Ser Leu Ser Val Met Ala Leu Asp Arg Tyr Val Ala Ile Ser Lys 115 120 125 Pro Leu His Tyr Val Thr Ile Met Ser Arg Gly Arg Cys Ile Gly Phe 130 135 140 Ile Val Ala Ser Trp Val Gly Gly Phe Val His Ser Ile Val Gln Ile 145 150 155 160 Ser Leu Leu Val Pro Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Thr 165 170 175

Page 3490

069269_0225_SL.TXT

Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ser Cys Thr 190 Asp Ile 180 185 Phe Ile Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Leu Thr Thr 195 200 205 Leu Trp Phe Phe Phe Leu Leu Val Ser Tyr Met Val Ile Leu Leu Val 210 215 220 Val Arg Ser Gln Ala Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 225 230 235 240 Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Thr Asp Lys Ala Ile Ser 260 265 270 Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Leu Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Lys Ser Ala Met Arg Arg Leu Lys Arg Arg 290 295 300 Leu Met Pro Ser Asp Arg Glu

305 310 <210> 3127 <211> 936 <212> DNA <213> Felis <400> 3127 atggagttgg caaaacctga ggaaacctcc ttcctgctcc gtcctcgtag catus gaaatagcac gtttggtcct tcatcatggt gcaatctctc acctcctgtc aagggtaaaa atttctttct cactgtgacc cgtcttggac aaggacgaag gaatttatat ttgtgcttgg tgcgagtccc atctgcttct accatctcct ttttgggact tatacatgac gccttcacac cctccatcac tcaatggttg tactcagtcc aactcttctg gcccatgtac cgctcccaag catcactcag

120

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Page 3491

069269_0225_SL.TXT

atcttcttct tccacctcct cgggggggca gacatttttt ctctctctgt catggccttc 360 gaccgctaca tggccatctc caagcccctg cactacgtga ccatcatgag cagggggcga 420 tgcactgccc tcatcgtggc ctcctgggtg gggggctttg tccactccat cgtgcagatt 480 tccctgttgc tgcccctccc tttctgtgga cccaatgttg ttgatggctt ctactgtgac 540 gtcccccagg tcctcaaact tgcctgtaca gacacctttg tacttgaact cctgatgatt 600 tccaacaatg gcttagtcac taccctgtgg tttattttcc tgcttgcatc ctacacagtc 660 atcttgacaa tgctaaggtc tcagggaggg gagggaagga ggaaagccat ctccacctgc 720 acctcccaca tcactgtggt gaccctgcac tttgtgccct gcatctacgt ctatgcccgg 780 cccttcactg ccctccccac agataaagcc atctctgtca ccttcactgt catctccccg 840 ctgctgaacc ccttgatcta cacgctgagg aaccaggaga tgaagtcagc catgaggaga 900 ctgaagagaa gactcatgcc ttctgacagg gaatag 936

<210> 3128 <211> 311 <212> PRT <213> Felis catus <400> 3128

Met Glu Leu Gly Asn Ser Thr Arg Val Lys Glu Phe Ile Phe Leu Gly 1 5 10 15 Leu Thr Gln Ser Gln Asn Leu Ser Leu Val Leu Phe Leu Ser Leu Cys 20 25 30 Leu Val Tyr Met Thr Thr Leu Leu Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Thr Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ser Val Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Val Leu Val Asp Leu Leu Ser Arg Thr Lys Thr Ile Ser Phe Asn Gly 85 90 95

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Cys Ile Thr Gln Ile Phe Phe Phe His Leu Leu Gly Gly Ala 110 Asp Ile 100 105 Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Met Ala Ile Ser Lys 115 120 125 Pro Leu His Tyr Val Thr Ile Met Ser Arg Gly Arg Cys Thr Ala Leu 130 135 140 Ile Val Ala Ser Trp Val Gly Gly Phe Val His Ser Ile Val Gln Ile 145 150 155 160 Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Val Asp Gly 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Val Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Val Thr Thr 195 200 205 Leu Trp Phe Ile Phe Leu Leu Ala Ser Tyr Thr Val Ile Leu Thr Met 210 215 220 Leu Arg Ser Gln Gly Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 225 230 235 240 Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Thr Asp Lys Ala Ile Ser 260 265 270 Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Leu Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Lys Ser Ala Met Arg Arg Leu Lys Arg Arg 290 295 300

Page 3493

069269_0225_SL.TXT

Leu Met Pro Ser Asp Arg Glu 305 310 <210> 3129 <211> 936 <212> DNA <213> Felis catus <400> 3129

atggatcagg gaaactacac cagagtgaaa gaatttattt tcctgggaat tactcagtct 60 caagagctga gctgggtctt gtttggcttc ttgtttttgg tgtacatgac aactctgctg 120 ggaaacctcc tcatcatggt cactgtgacc tgtgagtctc accttcacac ccccatgtac 180 ttcctgctcc gcaatctttc tgtgcttgac atctgcttct cctccatcac tgctcccaag 240 gtcctagttg atcttctgtc agagaaaaaa accatttcct tccatggctg tgtcacccaa 300 atgttcttct tccatcttct tggaggagca gatgtttttt ctctctctgt gatggccttt 360 gatcgctatg tagccatctc aagacccctt cactatatga ctatcatgag taagggacga 420 tgtactagcc tggtgctggc ctcctgggtg gggggctttg tccactccat cgtgcagatt 480 tctctgttgc tgcccctccc cttctgtgga cccaatgttc ttgacacgtt ctactgcgat 540 gttccccagg tcctcaaact cgcctgcacc gacaccttca ctctagagct cctgatgatt 600 tccaataacg gactggtcag ttggttgatt ttcttctttc tcctcatatc ttacacagtc 660 atcctgatga tgctgaggtc tcatgcaggg gagggaagga ggaaagccat ctccacctgc 720 acctcccaca tcaccgtggt aaccctgcac tttgtgccct gcatctatgt ctacgcccgg 780 cccttcactg ccctccccac agatactgcc atctctgtca ccttcaccgt catctcccct 840 ttgctcaatc ctatgatcta cacactgagg aatcaggaaa tgaagtcagc catggggaga 900 ctaaaaaaac gactagggca ttcagaaagg atttaa 936

<210> 3130 <211> 311 <212> PRT <213> Felis catus <400> 3130

Met Asp Gln Gly Asn Tyr Thr Arg Val Lys Glu Phe Ile Phe Leu Gly 1 5 10 15

Page 3494

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Ile Thr Gln Ser 20 Gln Glu Leu Ser Trp Val Leu Phe Gly Phe Leu Phe 25 30 Leu Val Tyr Met Thr Thr Leu Leu Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Thr Cys Glu Ser His Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ser Val Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80 Val Leu Val Asp Leu Leu Ser Glu Lys Lys Thr Ile Ser Phe His Gly 85 90 95 Cys Val Thr Gln Met Phe Phe Phe His Leu Leu Gly Gly Ala Asp Val 100 105 110 Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Val Ala Ile Ser Arg 115 120 125 Pro Leu His Tyr Met Thr Ile Met Ser Lys Gly Arg Cys Thr Ser Leu 130 135 140 Val Leu Ala Ser Trp Val Gly Gly Phe Val His Ser Ile Val Gln Ile 145 150 155 160 Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Thr 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Thr Leu Glu Leu Leu Met Ile Ser Asn Asn Gly Leu Val Ser Trp 195 200 205 Leu Ile Phe Phe Phe Leu Leu Ile Ser Tyr Thr Val Ile Leu Met Met 210 215 220

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Leu Arg 225 Ser His Ala Gly Glu Gly Arg Arg Lys Ala Ile Ser Thr Cys 230 235 240 Thr Ser His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Thr Asp Thr Ala Ile Ser 260 265 270 Val Thr Phe Thr Val Ile Ser Pro Leu Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Lys Ser Ala Met Gly Arg Leu Lys Lys Arg 290 295 300 Leu Gly His Ser Glu Arg Ile

305 310 <210> 3131 <211> 936 <212> DNA <213> Felis catus <400> 3131

atggagcagg gaaattacac cagggtgaaa gaatttattt ttcaaggact gacccagtcc 60 cgagagttaa gcttggcctt atttcttatg ttatttctgg tgtacacatc aactcttctg 120 ggaaacctcc tcatcatggt cactgtgacc tgcgagtccc gccttcacac gcccatgtac 180 ttcctgctcc gcaatctctc cgtcttggac atctgcttct cctccatcac cgctcccaag 240 gtcctcgtag acctcctgtc aaggacgaag accatctcct tcaatggttg catcactcag 300 atcttcttct tccacctcct cgggggagca gacatttttt ctctctctgt catggccttc 360 gaccgctaca tggccatctc caagcccctg cactacgtga ccatcatgag cagggggcga 420 tgcactgccc tcatcgtggc ctcctgggtg gggggctttg tccactccat cgtgcagatt 480 tccctgttgc tgcccctccc cttctgtgga cccagtgttg ttgatggctt ctactgtgac 540 gtcccccagg tcctcaaact cgcctgcacc agcacctttg ctcttgaggt cttaatgatt 600

Page 3496

069269_0225_SL.TXT tccaacaatg gcttaatctc tacactatgg tttgtcttcc tccttgtgtc ctacacagtc atcttgacga tgctgaggtc tcacgccggg gagggaagaa agaaagccat ctccacctgc accgcccaca tcactgtggt gactctgcac tttgtgccct gcatctacgt ctacgcccgg cccttcactg cccttcccat ggacagagct gtctccatca ccttcacggt catcatcccg gtcctgaacc ccatgatcta caccctcagg aaccaggaga tgaagtcagc catgaagaga ctgaggaaaa gacttggacc ttcagaaaaa gaatag

660

720

780

840

900

936 <210> 3132 <211> 311 <212> PRT <213> Felis catus <400> 3132

Met Glu Gln Gly Asn Tyr Thr Arg Val Lys Glu Phe Ile Phe Gln Gly 1 5 10 15

Leu Thr Gln Ser Arg Glu Leu Ser Leu Ala Leu Phe Leu Met Leu Phe 20 25 30

Leu Val Tyr Thr Ser Thr Leu Leu Gly Asn Leu Leu Ile Met Val Thr 35 40 45

Val Thr Cys Glu Ser Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg 50 55 60

Asn Leu Ser Val Leu Asp Ile Cys Phe Ser Ser Ile Thr Ala Pro Lys 65 70 75 80

Val Leu Val Asp Leu Leu Ser Arg Thr Lys Thr Ile Ser Phe Asn Gly 85 90 95

Cys Ile Thr Gln Ile Phe Phe Phe His Leu Leu Gly Gly Ala Asp Ile 100 105 110

Phe Ser Leu Ser Val Met Ala Phe Asp Arg Tyr Met Ala Ile Ser Lys 115 120 125

Pro Leu His Tyr Val Thr Ile Met Ser Arg Gly Arg Cys Thr Ala Leu Page 3497

130 135 069269_0225_SL.TXT 140 Ile Val Ala Ser Trp Val Gly Gly Phe Val His Ser Ile Val Gln Ile 145 150 155 160 Ser Leu Leu Leu Pro Leu Pro Phe Cys Gly Pro Ser Val Val Asp Gly 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Lys Leu Ala Cys Thr Ser Thr 180 185 190 Phe Ala Leu Glu Val Leu Met Ile Ser Asn Asn Gly Leu Ile Ser Thr 195 200 205 Leu Trp Phe Val Phe Leu Leu Val Ser Tyr Thr Val Ile Leu Thr Met 210 215 220 Leu Arg Ser His Ala Gly Glu Gly Arg Lys Lys Ala Ile Ser Thr Cys 225 230 235 240 Thr Ala His Ile Thr Val Val Thr Leu His Phe Val Pro Cys Ile Tyr 245 250 255 Val Tyr Ala Arg Pro Phe Thr Ala Leu Pro Met Asp Arg Ala Val Ser 260 265 270 Ile Thr Phe Thr Val Ile Ile Pro Val Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Lys Ser Ala Met Lys Arg Leu Arg Lys Arg 290 295 300 Leu Gly Pro Ser Glu Lys Glu 305 310

<210> 3133 <211> 886 <212> DNA <213> Felis catus

Page 3498

069269_0225_SL.TXT <400> 3133

ctttcagcaa cttgttcctc ctactataga tcaaggcatt caagacaggg gtgacaaagg 60 tgtagacaac agacacccat ttctgggtta tagctagagc tggggcataa atacataagg 120 ctacaggagc catactggag gagagccatg gtcagatgag aggaaaaggt ggagaaggcc 180 ttgcaccatc cctctgcaga gcagatcttc aaaatggcac ccacaatgaa gatgtatgag 240 atggagatca gggaacaggg aatggtaagc atgatgacac tgacaatgaa gatcatggct 300 tcttgtattt gagtgtctcc acaggccaac tgtatgatcg gagtacatca cagtagaagt 360 gagtgattct gttgtggcca caaaatggca gggggggaat cagagctgtt ggttgtatgg 420 ctagagtgaa accaaggacc agggctccca tagccaatta ggcacacagc taccatcgca 480 tgctgagggt gtaatgcagg gaatcctgaa tagctacaaa ccgatcataa gccatgatcc 540 ccaagaggaa acagtcagca ctgcccagga agacaaagaa gaacatctat gtgccacagt 600 cagtgaaaga gatgggcatt ctccccatgg tcaggaggtt gaccaaaggg agaggggcaa 660 caagtggaag agtataagat ctccggaact gccagattag ccagaaagaa agacatggga 720 atgtggagtg aacgttccgc ccagatagtg agaaagactg tggtattacc aatgagactg 780 ccaatataca ttagcaggaa agttacaaaa acatttgtat ctccaggatg ggtgaaaatg 840 gttgaaagtg gaactggatc tctatggttt agttttcatc ccccat 886

<210> 3134 <211> 58 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (58)..(58) <223> Any amino acid <400> 3134

Met Gly Met Trp Ser Glu Arg Ser Ala Gln Ile Val Arg Lys Thr Val 1 5 10 15

Val Leu Pro Met Arg Leu Pro Ile Tyr Ile Ser Arg Lys Val Thr Lys 20 25 30

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Thr Phe Val Ser Pro Gly Trp Val Lys Met Val Glu Ser Gly Thr Gly 35 40 45

Ser Leu Trp Phe Ser Phe His Pro Pro Xaa 50 55 <210> 3135 <211> 930 <212> DNA <213> Felis catus <400> 3135

ctagaacttc ctcagcgcct tctgtagggc atctttcagt tccttgttcc gcatactgta 60 gatcaaaggg tttaaaatgg gagtgatgaa ggtgtagacc acggacacca cccggcccat 120 ctcaggagag tagctggaac tgggagacaa gtatataaag ctggtgcagc catactgcag 180 gaggaccact aagatgtgcg aggagcaggt ggagaaggct cggtggcgcc cttctgttga 240 ccggatccgt aaaatggctg ccacgatgaa gacgtaggag atggagatta atgagagcgg 300 gacgcttagg acgatgaagc tgacgatgta cagggcagtc ttgtgaatgt gtgtgtccgc 360 acaggccagg cgcatgacag caggcatgtc acagtagaag tggtagatct cattgttgtt 420 gcagaatggg agacggaaga tcaaaatagt cagtggcagg gacagcagga accccagcac 480 cagggaccct accaccagct ccacacacaa gggccagctc atgacgtggg tgtatcgtag 540 agggtaacag atggctacaa accggtcata agccatgacc gcaagcagga cacaatcagc 600 tccacccagg aagacaaaga aaaacatttg ggtcccacag ccagggatgg aaacaggagt 660 cctgcccatt gaaagaaggt tcgccaaggc cagtggggca atggaagatg tgtagaagat 720 ttccagaact gccaggttcg ccaggaaaaa gtacatgggg atgtggaggg agtggttgat 780 ctggacaatg accgcaattg tggtgtttcc gctgaggctg atcaggtaca tcgtcaggaa 840 ggccacaaaa atgcctactt gtaccttagg gtcagctgag aatggacgaa agaagaattg 900 tatctttgca gttttattta tttcttccat 930

<210> 3136 <211> 309 <212> PRT <213> Felis catus

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<400> 3136 Asn Lys Thr Ala Lys Ile Gln Phe Phe Phe Arg 15 Pro Met 1 Glu Glu Ile 5 10 Phe Ser Ala Asp Pro Lys Val Gln Val Gly Ile Phe Val Ala Phe Leu 20 25 30 Thr Met Tyr Leu Ile Ser Leu Ser Gly Asn Thr Thr Ile Ala Val Ile 35 40 45 Val Gln Ile Asn His Ser Leu His Ile Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ala Val Leu Glu Ile Phe Tyr Thr Ser Ser Ile Ala Pro Leu 65 70 75 80 Ala Leu Ala Asn Leu Leu Ser Met Gly Arg Thr Pro Val Ser Ile Pro 85 90 95 Gly Cys Gly Thr Gln Met Phe Phe Phe Val Phe Leu Gly Gly Ala Asp 100 105 110 Cys Val Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys 115 120 125 Tyr Pro Leu Arg Tyr Thr His Val Met Ser Trp Pro Leu Cys Val Glu 130 135 140 Leu Val Val Gly Ser Leu Val Leu Gly Phe Leu Leu Ser Leu Pro Leu 145 150 155 160 Thr Ile Leu Ile Phe Arg Leu Pro Phe Cys Asn Asn Asn Glu Ile Tyr 165 170 175 His Phe Tyr Cys Asp Met Pro Ala Val Met Arg Leu Ala Cys Ala Asp 180 185 190 Thr His Ile His Lys Thr Ala Leu Tyr Ile Val Ser Phe Ile Val Leu 195 200 205

Page 3501

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Ser Val 210 Pro Leu Ser Leu Ile Ser Ile Ser Tyr Val Phe Ile Val Ala 215 220 Ala Ile Leu Arg Ile Arg Ser Thr Glu Gly Arg His Arg Ala Phe Ser 225 230 235 240 Thr Cys Ser Ser His Ile Leu Val Val Leu Leu Gln Tyr Gly Cys Thr 245 250 255 Ser Phe Ile Tyr Leu Ser Pro Ser Ser Ser Tyr Ser Pro Glu Met Gly 260 265 270 Arg Val Val Ser Val Val Tyr Thr Phe Ile Thr Pro Ile Leu Asn Pro 275 280 285 Leu Ile Tyr Ser Met Arg Asn Lys Glu Leu Lys Asp Ala Leu Gln Lys 290 295 300

Ala Leu Arg Lys Phe 305

<210> 3137 <211> 1007 <212> DNA <213> Felis catus <400> 3137 atgactcctt tccttgttcc aggtctgatg gaagaggaaa accggatggg ggtggtctac 60 tttcacttcc accccttctc aaccgaccca gcagtggctc ccctcctatt tgtggccttc 120 ttggtgtcgt acttaggaag tctcattgga aacatcacca ctgggctcac agtctggcga 180 gatcactccc cccacacccc gatgtgcttc ttcctcttcg cactggctgt gctggcaatt 240 ggctactcca ccaacattgc tcccctgact ctggctggca tcctttccac ggggcacatg 300 ctcgtctctc tccctggctg tggggcctag atgttcccct tcattcttct tggagggtct 360 gactgtgtct ttcttgctgt catggcctac gacaggtaca tggcaatctg ccacctagtg 420 cgttaccaca tcatcatgag ttggtggctc tgtgggcaga tgactttagg ttctttgggc 480 ctgggattcc tgttgtcact gcctttgacc attctgatct gccaccttcc aatctgtggc 540

Page 3502

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cgcaatgaaa tcttctgctt ctgtgacatg cctgacgtca tgcacctggc ctgtgtggac 600 acccgcatgc acaaggcagc tctctatgcc atcagtgtgg ccgcagtggc tgtccccttc 660 ctcctgatct gcctctccta tggctacatt gtggccacca tcctgaggat gaattcagct 720 gagggaaagt gccgggcttt ctccacctgt tcctcccacc tcatcgtggt tctcctgcag 780 tttggatgtt gcacccttat ctactttcac cccagctcca gttcctcttc agaagagggc 840 cgggcagtgt ctgttgtcta cacctttttt gcaccagtgc taaacccctt gatctatagc 900 ataaggagtc aagaggtgac cgatgcggga agaagactta cagtaagaac gtgctggttc 960 aggaaaccag aaatattcct tcctagaaga aatattcccc aaaccag 1007

<210> 3138 <211> 226 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (226)..(226) <223> Any amino acid <400> 3138

Met Phe Pro Phe Ile Leu Leu Gly Gly Ser Asp Cys Val Phe Leu Ala 1 5 10 15

Val Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys His Leu Val Arg Tyr 20 25 30

His Ile Ile Met Ser Trp Trp Leu Cys Gly Gln Met Thr Leu Gly Ser 35 40 45

Leu Gly Leu Gly Phe Leu Leu Ser Leu Pro Leu Thr Ile Leu Ile Cys 50 55 60

His Leu Pro Ile Cys Gly Arg Asn Glu Ile Phe Cys Phe Cys Asp Met 65 70 75 80

Pro Asp Val Met His Leu Ala Cys Val Asp Thr Arg Met His Lys Ala 85 90 95

Page 3503

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Ala Leu Tyr Ala Ile Ser Val 100 Ala Ala Val Ala Val Pro Phe Leu Leu 105 110 Ile Cys Leu Ser Tyr Gly Tyr Ile Val Ala Thr Ile Leu Arg Met Asn 115 120 125 Ser Ala Glu Gly Lys Cys Arg Ala Phe Ser Thr Cys Ser Ser His Leu 130 135 140 Ile Val Val Leu Leu Gln Phe Gly Cys Cys Thr Leu Ile Tyr Phe His 145 150 155 160 Pro Ser Ser Ser Ser Ser Ser Glu Glu Gly Arg Ala Val Ser Val Val 165 170 175 Tyr Thr Phe Phe Ala Pro Val Leu Asn Pro Leu Ile Tyr Ser Ile Arg 180 185 190 Ser Gln Glu Val Thr Asp Ala Gly Arg Arg Leu Thr Val Arg Thr Cys 195 200 205 Trp Phe Arg Lys Pro Glu Ile Phe Leu Pro Arg Arg Asn Ile Pro Gln 210 215 220

Thr Xaa 225 <210> 3139 <211> 937 <212> DNA <213> Felis catus <400> 3139 atggagggta caaatcagac tgggatgatt cacttccact tccgcccctt ctccaaactc cccgaggtgc agacgctgat tttcgtggcc ttcctcgtca tgtacctggt cagcatcggc ggcaacggct ccatttctct catcatctgg agcaaccgtt ctttgcacac ccccatgtac ttcttcctgg ccagcttggc agctctggag atctgctact cttccaccat tgcccctctg

120

180

240

Page 3504

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actctggcca gcgtcctgtc cgcagagaga gccctcatct ccctgcctgg ctgtggtgcc 300 cagatgttct tcttcatctt cctgggcagc gctgactgca ttctactagc tgtcatggcc 360 tatgacaggt ttgtggccat ctgccaccct ttgcgttaca ccctcatgat gagctggcgg 420 ttgtgcgtcc agctggccct ggggtctctg gcgctggggt tcatcttggc catgcagctg 480 actgtgctca tcttccgcct ccccttctgc cgcagccaag aaatcagcct gttctactgc 540 gatgtcctcc ctgtcatgag actggcctgt gcagatacat gggtccatga ggccaccctg 600 ttggtggtca gcctcaccgt cctcaccatc cccttcctgc ttatcgccct ctcctacgtt 660 ttcatcatgg ccgccatcct gaagatccgc tcggcagagg ggaggcacaa ggccttctcc 720 acctgctcct cccacctgac tgtggtcctg ctccagtacg gatgtggaag cctcatctac 780 ttgtgcccca gctccaggta ctctccagag agaggccagg tagtgtctgt ggtttacacc 840 ttcgtcaccc ctgtgctgaa ccccttgatc tacagcatga gaaacagaga gcttacggat 900 gctttgaaga gaacaatgat gaggttcctg ttgtcct 937

<210> 3140 <211> 313 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (313)..(313) <223> Any amino acid <400> 3140

Met Glu Gly Thr Asn Gln Thr Gly Met Ile His Phe His Phe Arg Pro 1 5 10 15 Phe Ser Lys Leu Pro Glu Val Gln Thr Leu Ile Phe Val Ala Phe Leu 20 25 30 Val Met Tyr Leu Val Ser Ile Gly Gly Asn Gly Ser Ile Ser Leu Ile 35 40 45 Ile Trp Ser Asn Arg Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ala

50 55 60

Page 3505

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Ser 65 Leu Ala Ala Leu Glu Ile Cys Tyr Ser Ser Thr Ile Ala Pro Leu 70 75 80 Thr Leu Ala Ser Val Leu Ser Ala Glu Arg Ala Leu Ile Ser Leu Pro 85 90 95 Gly Cys Gly Ala Gln Met Phe Phe Phe Ile Phe Leu Gly Ser Ala Asp 100 105 110 Cys Ile Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys 115 120 125 His Pro Leu Arg Tyr Thr Leu Met Met Ser Trp Arg Leu Cys Val Gln 130 135 140 Leu Ala Leu Gly Ser Leu Ala Leu Gly Phe Ile Leu Ala Met Gln Leu 145 150 155 160 Thr Val Leu Ile Phe Arg Leu Pro Phe Cys Arg Ser Gln Glu Ile Ser 165 170 175 Leu Phe Tyr Cys Asp Val Leu Pro Val Met Arg Leu Ala Cys Ala Asp 180 185 190 Thr Trp Val His Glu Ala Thr Leu Leu Val Val Ser Leu Thr Val Leu 195 200 205 Thr Ile Pro Phe Leu Leu Ile Ala Leu Ser Tyr Val Phe Ile Met Ala 210 215 220 Ala Ile Leu Lys Ile Arg Ser Ala Glu Gly Arg His Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ser His Leu Thr Val Val Leu Leu Gln Tyr Gly Cys Gly 245 250 255 Ser Leu Ile Tyr Leu Cys Pro Ser Ser Arg Tyr Ser Pro Glu Arg Gly 260 265 270

Page 3506

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Gln Val Val 275 Ser Val Val Tyr Thr Phe Val Thr Pro Val Leu Asn Pro 280 285 Leu Ile Tyr Ser Met Arg Asn Arg Glu Leu Thr Asp Ala Leu Lys Arg 290 295 300 Thr Met Met Arg Phe Leu Leu Ser Xaa 305 310

<210> 3141 <211> 925 <212> DNA <213> Felis catus <400> 3141 ctctggatga tgagtctttg gacaagccat tgccttcctt agggctgctt tcacctcctt 60 gtttctaatt gtacaaatga agggattcag aaggggtgtc aggatagtat ttggcactga 120 caccacctta ttaatcttag aggaagagtg tgctgtgggt ctcaggtacg tgaacaaaac 180 ggcaccatag agcagggaga ctgctgtcag gtgggaggca caggtcgaga aaatcttctg 240 ttggccagtg gctgaaggga tctgtaggat ggtggacagg atacagatat aagaagtcgc 300 tgtgaagagg agtgaccctg ggatcacctg gacggtcgcc aaaagacccg ggagctccaa 360 aatgcttgtg tctgtgcagg ctgctttcaa aatgggacca acatcacagt agaaatggtt 420 gatgacattg tcgccacaga atggcaactg gatgagcggt agcatctgac aaaagacgat 480 ggtaaagcct accacccagg agctgagggc aagttgcagg cagaggttgc tggtcatagt 540 ggtggggtag cgaaggggct tgcagatggc caggtaatgg tcaaaagaca tgacaatgaa 600 gataaagaac tcggcggttc ccgggaaaaa gtggaagaag gcagcagggg atgcagatag 660 ctgttcttgc caccacaaac gtttctgata gtttgggaat gaccgtggta gggaaccaga 720 tctctaggaa ggacaaggtg caaaggaaga agtacattgg tatttgtagc ctgggctcag 780 cccagacaat ggagattttg aacccattgc ctgcaagggt taatacgtag atgcaaaaga 840 tcacgagaaa gagagggatt tgtagtcctt gggtatcagg aaagcctaga aggatgaact 900 ctgtgatggt cgtgccattt gtcat 925

Page 3507

069269_0225_SL.TXT <210> 3142 <211> 197 <212> PRT <213> Felis catus

<400> 3142 Tyr Leu Ala Ile Cys 10 Lys Pro Leu Arg Tyr 15 Pro Met 1 Ser Phe Asp His 5 Thr Thr Met Thr Ser Asn Leu Cys Leu Gln Leu Ala Leu Ser Ser Trp 20 25 30 Val Val Gly Phe Thr Ile Val Phe Cys Gln Met Leu Pro Leu Ile Gln 35 40 45 Leu Pro Phe Cys Gly Asp Asn Val Ile Asn His Phe Tyr Cys Asp Val 50 55 60 Gly Pro Ile Leu Lys Ala Ala Cys Thr Asp Thr Ser Ile Leu Glu Leu 65 70 75 80 Pro Gly Leu Leu Ala Thr Val Gln Val Ile Pro Gly Ser Leu Leu Phe 85 90 95 Thr Ala Thr Ser Tyr Ile Cys Ile Leu Ser Thr Ile Leu Gln Ile Pro 100 105 110 Ser Ala Thr Gly Gln Gln Lys Ile Phe Ser Thr Cys Ala Ser His Leu 115 120 125 Thr Ala Val Ser Leu Leu Tyr Gly Ala Val Leu Phe Thr Tyr Leu Arg 130 135 140 Pro Thr Ala His Ser Ser Ser Lys Ile Asn Lys Val Val Ser Val Pro 145 150 155 160 Asn Thr Ile Leu Thr Pro Leu Leu Asn Pro Phe Ile Cys Thr Ile Arg 165 170 175 Asn Lys Glu Val Lys Ala Ala Leu Arg Lys Ala Met Ala Cys Pro Lys 180 185 190

Page 3508

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Thr His His Pro Glu 195 <210> 3143 <211> 947 <212> DNA <213> Felis catus <400> 3143

ccggttatcc ttagtatcaa ggacatgatt ctgtttattg tctctctcaa tacttctttc 60 accttttcat ttctcaaact ataaataaaa ggattcagga gaggggtcac cactgtaatg 120 aggacagcag ctaccttgtc aaaattcagg gaatagttct gattgggtct cacatacaca 180 aagatattgc tcccgtaagc aatggcaatg accgtgatat gagaagcaca ggtagaaaaa 240 gccttttgac ggccttgggc cgaggggatg cgcaggatgg tagagatgat gtaggtatag 300 gacgcagtag tgaatgccag ggagctcagg atgacaaggg cagataggag gaagttgatc 360 tgctcaatga ggtgagtatc tacacaggcc acctgcagaa gaggggcaat gtcacagaaa 420 aaatgattga tttcttttcc acagtaaggt agccttgtca ctacaatggt tggtaccaac 480 acagacagga aggctcctac ccagcagctc agaaccagca ggaggcaggt cctgctgttc 540 atgatgatgg tatagcgcag ggggttacag atggccacgt agcggtcaaa ggacatcact 600 gctaggagga taaactccac tgtccccaga aagaagtaga aatatgtttg agtgatacag 660 ccagcaaagg atatggtttt cttctctcct aggaggcagg ctagcaactt tggtgtaacg 720 acagtggtgt ataaaatatc cagaaaagac agattactga ggaaaatgta cattggggtt 780 tgcaggtgat tatcagtcca tattaggaag atgatgacaa tgtttcctat tgctgttagt 840 gtgtacgtca gcaaaagaac cacaaagagg agtattcgaa gctccaggag agtgggaaag 900 gcgatcaggg tgaattcagt caccgtgctc caatttccca tgggcat 947

<210> 3144 <211> 316 <212> PRT <213> Felis catus <400> 3144

Met Pro Met Gly Asn Trp Ser Thr Val Thr Glu Phe Thr Leu Ile Ala Page 3509

0 6926 »9_02 25_S iL.TX T 1 5 10 15 Phe Pro Thr Leu Leu Glu Leu Arg Ile Leu Leu Phe Val Val Leu Leu 20 25 30 Leu Thr Tyr Thr Leu Thr Ala Ile Gly Asn Ile Val Ile Ile Phe Leu 35 40 45 Ile Trp Thr Asp Asn His Leu Gln Thr Pro Met Tyr Ile Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Ile Leu Tyr Thr Thr Val Val Thr Pro Lys 65 70 75 80 Leu Leu Ala Cys Leu Leu Gly Glu Lys Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Ile Thr Gln Thr Tyr Phe Tyr Phe Phe Leu Gly Thr Val Glu Phe 100 105 110 Ile Leu Leu Ala Val Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Thr Ile Ile Met Asn Ser Arg Thr Cys Leu Leu Leu 130 135 140 Val Leu Ser Cys Trp Val Gly Ala Phe Leu Ser Val Leu Val Pro Thr 145 150 155 160 Ile Val Val Thr Arg Leu Pro Tyr Cys Gly Lys Glu Ile Asn His Phe 165 170 175 Phe Cys Asp Ile Ala Pro Leu Leu Gln Val Ala Cys Val Asp Thr His 180 185 190 Leu Ile Glu Gln Ile Asn Phe Leu Leu Ser Ala Leu Val Ile Leu Ser 195 200 205 Ser Leu Ala Phe Thr Thr Ala Ser Tyr Thr Tyr Ile Ile Ser Thr Ile

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210 215 220

Leu 225 Arg Ile Pro Ser Ala Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys 230 235 240 Ala Ser His Ile Thr Val Ile Ala Ile Ala Tyr Gly Ser Asn Ile Phe 245 250 255 Val Tyr Val Arg Pro Asn Gln Asn Tyr Ser Leu Asn Phe Asp Lys Val 260 265 270 Ala Ala Val Leu Ile Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Glu Lys Val Lys Glu Val Leu Arg Glu Thr Ile 290 295 300 Asn Arg Ile Met Ser Leu Ile Leu Arg Ile Thr Gly 305 310 315

<210> 3145 <211> 948 <212> DNA <213> Felis catus <400> 3145

tcaagttctc ctgtgtaata aggacatgat tttgctgatt gcttctctca aaactttttt 60 tacctttgca ttccttagac tataaatgaa ggggttcaga agaggcgtca ccatagtggt 120 gagaacagca gtcactttgt caaaatccag cgaacggctc tggctgggcc tcacatacat 180 gaagatgttg ctcccatagg caatggagac gaccgtgatg tgagaagcac aggtggaaaa 240 tgccttctga cgtccttggg ctgaggggat gcgcaaaatg gtagaaatga tgtaggtgta 300 agacacaatg gtgagtacca gcgaggtcag gaggacgagg gaagataaga ggaagtttat 360 catctcaatg aaatgagtgt ctatgcaggc cacctgtagc agaggggcaa tgtcacagaa 420 aaaatgactg atttctttat gacagtaggg cagtctggac actacaatag ttgggcacag 480 cactgagaag aaggctccta cccagcatcc cagaaccagt aggagacaga cgttgctgtt 540 catgatgatg gtatagcgca gggggttaca gatggccacg tagcggtcaa aggacatcac 600

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tgctaggagg ataaactcca ctgtccccaa gaaaaagaag aagtatgttt gggttatgca 660 gccagcaaaa gatatggtct tcctgtcctc tagaagacaa gctaatagct ttggggtaac 720 tgaggtagtg tataaaatgt ccagaaatga caaattactg aggaagaagt acattggggt 780 ttggaggcgg ttatcagccc atattaggga aacgatgaca atatttcctg tgagagttaa 840 catgtaaata aacaagagga ccacaaagag agagatctga agcttccgga taacagggaa 900 ggcagtcagg gtgaattcag tcactgtggt ctgattttgc atatccat 948

<210> 3146 <211> 315 <212> PRT <213> Felis catus <400> 3146

Met Asp Met Gln Asn Gln Thr Thr Val Thr Glu Phe Thr Leu Thr Ala 1 5 10 15 Phe Pro Val Ile Arg Lys Leu Gln Ile Ser Leu Phe Val Val Leu Leu 20 25 30 Phe Ile Tyr Met Leu Thr Leu Thr Gly Asn Ile Val Ile Val Ser Leu 35 40 45 Ile Trp Ala Asp Asn Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Ile Leu Tyr Thr Thr Ser Val Thr Pro Lys 65 70 75 80 Leu Leu Ala Cys Leu Leu Glu Asp Arg Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Ile Thr Gln Thr Tyr Phe Phe Phe Phe Leu Gly Thr Val Glu Phe 100 105 110 Ile Leu Leu Ala Val Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125

Page 3512

Pro Leu 130 Arg Tyr Thr Ile Ile 135 069269_0225_SL.TXT Met Asn Ser Asn Val Cys 140 Leu Leu Leu Val Leu Gly Cys Trp Val Gly Ala Phe Phe Ser Val Leu Cys Pro Thr 145 150 155 160 Ile Val Val Ser Arg Leu Pro Tyr Cys His Lys Glu Ile Ser His Phe 165 170 175 Phe Cys Asp Ile Ala Pro Leu Leu Gln Val Ala Cys Ile Asp Thr His 180 185 190 Phe Ile Glu Met Ile Asn Phe Leu Leu Ser Ser Leu Val Leu Leu Thr 195 200 205 Ser Leu Val Leu Thr Ile Val Ser Tyr Thr Tyr Ile Ile Ser Thr Ile 210 215 220 Leu Arg Ile Pro Ser Ala Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ser His Ile Thr Val Val Ser Ile Ala Tyr Gly Ser Asn Ile Phe 245 250 255 Met Tyr Val Arg Pro Ser Gln Ser Arg Ser Leu Asp Phe Asp Lys Val 260 265 270 Thr Ala Val Leu Thr Thr Met Val Thr Pro Leu Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Ala Lys Val Lys Lys Val Leu Arg Glu Ala Ile 290 295 300 Ser Lys Ile Met Ser Leu Leu His Arg Arg Thr 305 310 315

<210> 3147 <211> 941 <212> DNA <213> Felis catus

Page 3513

069269_0225_SL.TXT <400> 3147

cccttggaat gtgatggaac tatcctgcta actgactctt tcaagacttc ctttaccttt 60 tcattcctca agctataaat gaaaggattc agaagagggg tcaccattgt agtgaggaca 120 gccgtcactt tatcaaaatc cagtgaatgg ctctggttgg gcctcacgta cgtgaagatg 180 gagcttccat aggcaatgga gacaactgtg atgtgagaag cacaggtgga aaaggccttc 240 tgacgtcctt gggctgaggg gatgcgcatg atggtagaaa tgatgcaggt gtaggatgtg 300 gtggtgagca ccagtgaact caggaccaca agggaagata agaggaagtt tatcatctca 360 atgaagtggg tatcaatgca ggccacctgt agtaaagggg caatgtcaca gaagaaatga 420 ctaatttctc tatgacagta gggcaatctg gacaccacaa tagttgggca tagcactgag 480 agaaaggctc ccacccagca gcccagaacc agcaggagac agaccctact gttcatgatg 540 atggtatagc gcagggggtt acagatggcc acatagcggt caaaggacat caccgctagg 600 aggataaact ccacagtccc cagaaagaag tagaaataaa cttgagtgat gcagccagca 660 aaggatatgg ttttcttctt ttctaagaga caagctagca actttggggc aatagtagtt 720 gtgaacaaaa tgtccaaaaa tgacaaatta ctaaggaaga aatacattgg tgtctggaga 780 cgattatcag tccatattaa ggaaatgatg acaatgtttc ctgttatgat gagcatataa 840 accagcagga gaatgacaaa cagcaagact tgaagctcct ggatggcagg aagggagacc 900 aatgtgaatt cactcaatgt actctggttt ctcatagcca t 941

<210> 3148 <211> 314 <212> PRT <213> Felis catus <400> 3148

Met 1 Ala Met Arg Asn Gln Ser Thr Leu Ser Glu Phe Thr Leu Val Ser 5 10 15 Leu Pro Ala Ile Gln Glu Leu Gln Val Leu Leu Phe Val Ile Leu Leu 20 25 30 Leu Val Tyr Met Leu Ile Ile Thr Gly Asn Ile Val Ile Ile Ser Leu 35 40 45

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Ile Trp 50 Thr Asp Asn Arg Leu Gln 55 Thr Pro Met Tyr Phe Phe Leu 60 Ser Asn Leu Ser Phe Leu Asp Ile Leu Phe Thr Thr Thr Ile Ala Pro Lys 65 70 75 80 Leu Leu Ala Cys Leu Leu Glu Lys Lys Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Ile Thr Gln Val Tyr Phe Tyr Phe Phe Leu Gly Thr Val Glu Phe 100 105 110 Ile Leu Leu Ala Val Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Thr Ile Ile Met Asn Ser Arg Val Cys Leu Leu Leu 130 135 140 Val Leu Gly Cys Trp Val Gly Ala Phe Leu Ser Val Leu Cys Pro Thr 145 150 155 160 Ile Val Val Ser Arg Leu Pro Tyr Cys His Arg Glu Ile Ser His Phe 165 170 175 Phe Cys Asp Ile Ala Pro Leu Leu Gln Val Ala Cys Ile Asp Thr His 180 185 190 Phe Ile Glu Met Ile Asn Phe Leu Leu Ser Ser Leu Val Val Leu Ser 195 200 205 Ser Leu Val Leu Thr Thr Thr Ser Tyr Thr Cys Ile Ile Ser Thr Ile 210 215 220 Met Arg Ile Pro Ser Ala Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ser His Ile Thr Val Val Ser Ile Ala Tyr Gly Ser Ser Ile Phe 245 250 255

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Thr Tyr Val Arg 260 Pro Asn Gln Ser His Ser Leu Asp Phe Asp Lys Val 265 270 Thr Ala Val Leu Thr Thr Met Val Thr Pro Leu Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Glu Lys Val Lys Glu Val Leu Lys Glu Ser Val 290 295 300 Ser Arg Ile Val Pro Ser His Ser Lys Gly

305 310 <210> 3149 <211> 936 <212> DNA <213> Felis catus <400> 3149

ttataaaggc atttttcttt ttaagcgttt tatcagtgca tctttcactt ccttgttcct 60 cagactatat atcaggggat tcaacatggg aatcacggtg gtgtaaaata ctgaggatac 120 tttctcctgg atgagtgagc tgcgggaagc aggtttgaga tacatggaca tgagagtccc 180 ataaaatgta agaacagctg tcaagtggga actgcaggtg ctgaaggctt tggacctgcc 240 ctctgtcgag tgcatgcgga ggatgctgga gagaataaag acataagaaa tgatgattgt 300 caggctggtg actatcatgt taaatccacc aatgacaaaa atcaaaagtt catcaatata 360 agtgcttgaa caagagagtt taataagtgg gatgatgtca cagaaataat gtttaatgat 420 gttcgagcca cagaaattca gccttaatat acaacctcca tgaatcatag catcggtaaa 480 tccaattgag aagccagaag ccaccagcag agaacagact cgaggggaca tgatgacatt 540 gtagagcagg gggctgcaga tggcgacata gcgatcatag gccattacag ctaacatgta 600 gcactcagaa atgacaaaca tacagaaaaa aaatagctga gtcatgcatc cagaatagga 660 gatagctgta tccctgcata aaagctctgc cagcaacttg ggagtaataa cagaagaata 720 gcacaaatct accaaagaca gactactgag gaaatggtac ataggggtgt gaagttggga 780 actgaaccta attattgaga tcatgccgag atttcctacc actgtgactg tataaatccc 840 taagaagagg cagaaaagag gcagctgaag ctctggttgg tcagttagtc cccaaagaag 900

Page 3516

069269_0225_SL.TXT aaactcagtc actgtggaat gatttcttgt gcccat

936 <210> 3150 <211> 311 <212> PRT <213> Felis catus <400> 3150

Met 1 Gly Thr Arg Asn 5 His Ser Thr Val Thr Glu Phe Leu Leu Trp Gly 10 15 Leu Thr Asp Gln Pro Glu Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu 20 25 30 Gly Ile Tyr Thr Val Thr Val Val Gly Asn Leu Gly Met Ile Ser Ile 35 40 45 Ile Arg Phe Ser Ser Gln Leu His Thr Pro Met Tyr His Phe Leu Ser 50 55 60 Ser Leu Ser Leu Val Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 Leu Leu Ala Glu Leu Leu Cys Arg Asp Thr Ala Ile Ser Tyr Ser Gly 85 90 95 Cys Met Thr Gln Leu Phe Phe Phe Cys Met Phe Val Ile Ser Glu Cys 100 105 110 Tyr Met Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr Asn Val Ile Met Ser Pro Arg Val Cys Ser Leu Leu 130 135 140 Val Ala Ser Gly Phe Ser Ile Gly Phe Thr Asp Ala Met Ile His Gly 145 150 155 160 Gly Cys Ile Leu Arg Leu Asn Phe Cys Gly Ser Asn Ile Ile Lys His 165 170 175

Page 3517

069269_0225_SL.TXT

Tyr Phe Cys Asp Ile Ile Pro Leu Ile Lys Leu Ser Cys Ser 190 Ser Thr 180 185 Tyr Ile Asp Glu Leu Leu Ile Phe Val Ile Gly Gly Phe Asn Met Ile 195 200 205 Val Thr Ser Leu Thr Ile Ile Ile Ser Tyr Val Phe Ile Leu Ser Ser 210 215 220 Ile Leu Arg Met His Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Ala Val Leu Thr Phe Tyr Gly Thr Leu Met 245 250 255 Ser Met Tyr Leu Lys Pro Ala Ser Arg Ser Ser Leu Ile Gln Glu Lys 260 265 270 Val Ser Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Ile Lys Arg 290 295 300 Leu Lys Arg Lys Met Pro Leu

305 310 <210> 3151 <211> 945 <212> DNA <213> Felis catus <400> 3151 atgaatccag caaatcattc ccaggtgaca ggctttgtcc tcctggggct ctctcaggta tgggggcttc ggttcctctt ctttattatc ttctctgttg tgtatcttat gaccgtagct ggaaatctcc ttattgtggc catagtgacc tgtgactcac gcctccacac aaccatgtac tttctcttag gcaacctttc tttcctagac ctttgctact cttccatcac agcacctagg

120

180

240

Page 3518

069269_0225_SL.TXT atgctgtttg acttgctctc agacaacccc atcatttcct tcggcagctg cctgactcag ctcttcttct tccacttcat tggaggcatc aagatcttcc tgctgacggt gatggcatat gaccgctatg ttgccatctc ccagccattg cgctacatgc ttgtgatgaa ccgcacagtc tgtgggctcc tcatggtagc ctcctgggtg gggggcttca tccactccat tgtgcagatt ggactgacta tccagctgcc attctgtggg cctgacaagc tggacaactt ttactgtgac gtgcctcagc taatcaaatt agcctgcacg gatacctttg tcttagagct tctgatggtg tctaacaatg gcctggtaac tttgatgtgt tttctggtgc tcctgggatc ctacacggca ctgctagtca tgctccgagg ccactcatgg gagggccgga gcaaagccct atccacttgt gcctctcaca ttgctgtggt gaccttaatt tttgtgcctt gtgtctacat ctatgcgagg ccatttcgga cattccctat ggacaaggcg gtctctgttc tgtacacaat ggtcactccc atgctgaatc ctgccatcta taccctgaga aacaaggaag tgatcgtggc catgaagaaa ctgtggagga ggcagaaaga ccttctgggc cccctggagc actga <210> 3152 <211> 314 <212> PRT <213> Felis catus

300

360

420

480

540

600

660

720

780

840

900

945

<400> 3152 Asn His 5 Ser Gln Val Thr Gly Phe Val Leu Leu Gly Met Asn 1 Pro Ala 10 15 Leu Ser Gln Val Trp Gly Leu Arg Phe Leu Phe Phe Ile Ile Phe Ser 20 25 30 Val Val Tyr Leu Met Thr Val Ala Gly Asn Leu Leu Ile Val Ala Ile 35 40 45 Val Thr Cys Asp Ser Arg Leu His Thr Thr Met Tyr Phe Leu Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Leu Cys Tyr Ser Ser Ile Thr Ala Pro Arg 65 70 75 80 Met Leu Phe Asp Leu Leu Ser Asp Asn Pro Ile Ile Ser Phe Gly Ser Page 3519

069269_0225_SL.TXT

85 90 95

Cys Leu Thr Gln Leu 100 Phe Phe Phe His Phe Ile Gly Gly Ile Lys Ile 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Ser Gln 115 120 125 Pro Leu Arg Tyr Met Leu Val Met Asn Arg Thr Val Cys Gly Leu Leu 130 135 140 Met Val Ala Ser Trp Val Gly Gly Phe Ile His Ser Ile Val Gln Ile 145 150 155 160 Gly Leu Thr Ile Gln Leu Pro Phe Cys Gly Pro Asp Lys Leu Asp Asn 165 170 175 Phe Tyr Cys Asp Val Pro Gln Leu Ile Lys Leu Ala Cys Thr Asp Thr 180 185 190 Phe Val Leu Glu Leu Leu Met Val Ser Asn Asn Gly Leu Val Thr Leu 195 200 205 Met Cys Phe Leu Val Leu Leu Gly Ser Tyr Thr Ala Leu Leu Val Met 210 215 220 Leu Arg Gly His Ser Trp Glu Gly Arg Ser Lys Ala Leu Ser Thr Cys 225 230 235 240 Ala Ser His Ile Ala Val Val Thr Leu Ile Phe Val Pro Cys Val Tyr 245 250 255 Ile Tyr Ala Arg Pro Phe Arg Thr Phe Pro Met Asp Lys Ala Val Ser 260 265 270 Val Leu Tyr Thr Met Val Thr Pro Met Leu Asn Pro Ala Ile Tyr Thr 275 280 285

Leu Arg Asn Lys Glu Val Ile Val Ala Met Lys Lys Leu Trp Arg Arg Page 3520

069269_0225_SL.TXT

290 295 300

Gln Lys Asp Leu Leu Gly Pro Leu Glu His

305 310 <210> 3153 <211> 935 <212> DNA <213> Felis catus <400> 3153

tagtccctcg cagccatggt tctgtgccac atcagggcaa ctcttagggc ctgcttcacc 60 ttatcattgc ggagactgaa gatgaatggg ttcaggagag gtgtgatgat acagctcagg 120 acggaggccc ctttgtggag cagtgtggac tgagcctctg acatacggat gtagagaaaa 180 atggagctgc catagacaat gatgaccact gtaaggtgtg aggcacaagt ggagaatgct 240 ttttttcgct ccgcaggtgt gggggccctg aaaacagtgg caagaatgca ggcgtaggaa 300 accgaggtca gtgccagcga gcccagtaac actgacgtgg agagcacgaa agccaccagc 360 tccagtaagc gggtgtctcc gcaagagagc ctcagcaagg gccaactgtc acagaaaaag 420 tggtcaatac cattggggcc acagaaaggc aagttggcca tgaggatggt ggggcacagg 480 acccagagga atccagctaa ccaggaggcc agaaccagtt gggaacagac acggccattc 540 attagagtct catagtggag aggtcggcag attgccaagt aacgatctag agacatgaca 600 gctaagagga agaagtcggt ggtgcctagg aggaagtaga agtaagactg gatgatgcag 660 gtggcgaatg agatggagtg gtcccccgta agaatgacaa caagcatctt gggaaccaca 720 acagacacga gcaacagctc caggaaggac aggtgcctca ggaagaagta catctgtgtg 780 tgcaggtgtc gattcgtcca actgagccca atgatgagca ggttgcctgt ggccgttaca 840 gcgtaggctg ccatcaaagc caggaacagc aggaactgca ggatgtggct tctagggaaa 900 cccagaagga caaaccctgt cacgtgagtc cagtt 935

<210> 3154 <211> 312 <212> PRT <213> Felis catus

Page 3521

069269_0225_SL.TXT <220>

<221> MOD_RES <222> (312)..(312) <223> Any amino acid

<400> 3154 Asn 1 Trp Thr His Val Thr Gly Phe 5 Val Leu 10 Leu Gly Phe Pro Arg Ser 15 His Ile Leu Gln Phe Leu Leu Phe Leu Ala Leu Met Ala Ala Tyr Ala 20 25 30 Val Thr Ala Thr Gly Asn Leu Leu Ile Ile Gly Leu Ser Trp Thr Asn 35 40 45 Arg His Leu His Thr Gln Met Tyr Phe Phe Leu Arg His Leu Ser Phe 50 55 60 Leu Glu Leu Leu Leu Val Ser Val Val Val Pro Lys Met Leu Val Val 65 70 75 80 Ile Leu Thr Gly Asp His Ser Ile Ser Phe Ala Thr Cys Ile Ile Gln 85 90 95 Ser Tyr Phe Tyr Phe Leu Leu Gly Thr Thr Asp Phe Phe Leu Leu Ala 100 105 110 Val Met Ser Leu Asp Arg Tyr Leu Ala Ile Cys Arg Pro Leu His Tyr 115 120 125 Glu Thr Leu Met Asn Gly Arg Val Cys Ser Gln Leu Val Leu Ala Ser 130 135 140 Trp Leu Ala Gly Phe Leu Trp Val Leu Cys Pro Thr Ile Leu Met Ala 145 150 155 160 Asn Leu Pro Phe Cys Gly Pro Asn Gly Ile Asp His Phe Phe Cys Asp 165 170 175 Ser Trp Pro Leu Leu Arg Leu Ser Cys Gly Asp Thr Arg Leu Leu Glu 180 185 190

Page 3522

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Leu Val Ala Phe Val Leu Ser Thr Ser Val Leu Leu Gly Ser Leu Ala 195 200 205 Leu Thr Ser Val Ser Tyr Ala Cys Ile Leu Ala Thr Val Phe Arg Ala 210 215 220 Pro Thr Pro Ala Glu Arg Lys Lys Ala Phe Ser Thr Cys Ala Ser His 225 230 235 240 Leu Thr Val Val Ile Ile Val Tyr Gly Ser Ser Ile Phe Leu Tyr Ile 245 250 255 Arg Met Ser Glu Ala Gln Ser Thr Leu Leu His Lys Gly Ala Ser Val 260 265 270 Leu Ser Cys Ile Ile Thr Pro Leu Leu Asn Pro Phe Ile Phe Ser Leu 275 280 285 Arg Asn Asp Lys Val Lys Gln Ala Leu Arg Val Ala Leu Met Trp His 290 295 300 Arg Thr Met Ala Ala Arg Asp Xaa

305 310 <210> 3155 <211> 929 <212> DNA <213> Felis catus <400> 3155 atggcagtag gaaatgcctc ttcagtgacc cagtttatcc tgctgggttt aacacaacag ccagaactcc agctgcctct cttcttcatt ttcttaggaa tctacgtggt caccgtgatg gggaacatgg gcttgattat tctgattggt ctgaagcctc acctgcacac tcccatgtac tactttctct tcaacctttc cttcattgat ctctgctact cgtctgtcat aatgcctaga atgctgatag gttttgtaaa gcaaaacacc atctcttacg cagagtgcgt ggctcagctc tgtttcttct ccttctttgt cattgatgag tgctatattt tgacatcgat ggcctatgac

120

180

240

300

360

Page 3523

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cggtatgtgg ccatctgtaa gcccctgctt tacaaggcca tcatgtccca ccaggtctgc 420 ctcatgctga tggcaggaac atatgcagtg gggtttgtgg gtgccatggc gcacaccggg 480 tgcatgctga ggctcacgtt ctgtgatggc aacatcatta atcattacat gtgtgacata 540 cctcctctcc ttcagctctc ctgcacaagc acctacgtca acgagctggt ggttttcatt 600 gtggtgggaa tcaatgtaat aatgcccagt ctcaccatca ccatttctta caccttgatc 660 gtctccaaca tcctccgtat ccgttctaca gggggcaggt ccaaagcctt cagtacctgc 720 agctcccaca tagttactgt ttctctcttc tttggagcat cggcattcat gtatctaaga 780 cctttttcta ctgggtattt ggatcaagat aaggtatcca cagtttttta taccattgtg 840 gggccaatgt tgaatccttt tatctatagt ctgaggaaca aagatgtcaa aattgcactg 900 agtaagactt ttaagaaaag ggtgttctc 929

<210> 3156 <211> 310 <212> PRT <213> Felis catus <400> 3156

Met Ala Val Gly Asn Ala Ser Ser Val Thr Gln Phe Ile Leu Leu Gly 1 5 10 15 Leu Thr Gln Gln Pro Glu Leu Gln Leu Pro Leu Phe Phe Ile Phe Leu 20 25 30 Gly Ile Tyr Val Val Thr Val Met Gly Asn Met Gly Leu Ile Ile Leu 35 40 45 Ile Gly Leu Lys Pro His Leu His Thr Pro Met Tyr Tyr Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Met Pro Arg 65 70 75 80 Met Leu Ile Gly Phe Val Lys Gln Asn Thr Ile Ser Tyr Ala Glu Cys 85 90 95 Val Ala Gln Leu Cys Phe Phe Ser Phe Phe Val Ile Asp Glu Cys Tyr Page 352- 4

100

069269_0225_SL.TXT 105 110

Ile Leu Thr 115 Ser Met Ala Tyr Asp 120 Arg Tyr Val Ala Ile 125 Cys Lys Pro Leu Leu Tyr Lys Ala Ile Met Ser His Gln Val Cys Leu Met Leu Met 130 135 140 Ala Gly Thr Tyr Ala Val Gly Phe Val Gly Ala Met Ala His Thr Gly 145 150 155 160 Cys Met Leu Arg Leu Thr Phe Cys Asp Gly Asn Ile Ile Asn His Tyr 165 170 175 Met Cys Asp Ile Pro Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr Tyr 180 185 190 Val Asn Glu Leu Val Val Phe Ile Val Val Gly Ile Asn Val Ile Met 195 200 205 Pro Ser Leu Thr Ile Thr Ile Ser Tyr Thr Leu Ile Val Ser Asn Ile 210 215 220 Leu Arg Ile Arg Ser Thr Gly Gly Arg Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Ile Val Thr Val Ser Leu Phe Phe Gly Ala Ser Ala Phe 245 250 255 Met Tyr Leu Arg Pro Phe Ser Thr Gly Tyr Leu Asp Gln Asp Lys Val 260 265 270 Ser Thr Val Phe Tyr Thr Ile Val Gly Pro Met Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Ile Ala Leu Ser Lys Thr Phe 290 295 300 Lys Lys Arg Val Phe Ser

Page 3525

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305

310 <210> 3157 <211> 930 <212> DNA <213> Felis catus <400> 3157

gcctccgcgc agaagtcttt gcagagcccg cttgacctcc ttgttccgcg gagtgtaaat 60 gaaaggggtg agcgtggggg tgatgattgt gtagaagaca gcaggggccc cagcccctgc 120 ccccgcggag caaggctgca ggtagatgca tacaggtggc atgcagttca gcagcaccac 180 ggtgaggtgg gaggtgcagg tggagaaggc acgctgccag ccttgggcag ggcggacccg 240 cagcacggcc gccacactaa agacgtccgg tatgatgatg aagggaagac acctgccgcc 300 acaaggccga tgttggcaag cgtgacgggc tcactgatgg tggtgtctgc gcaggccagc 360 ttcagcacgg ggggcatgtc acagaagaag cgggcgatgt ggtgaggacc acagtagagc 420 aggcgaaagg tgagggcggt gtggacggca gagtgcccag cacctatggc ccaagtgatc 480 ccagcccgcc ctgcacacat ccgtctgttc atgtccccct gggtagtgta ggggttggca 540 gatagctagg tagcggtcgt aggccgtgat ggcgtataga aagtactcgg tgctggccag 600 gaaacggaag cagtaaagct gaaccgcaca gccctcagag gagatcacct tcccatgcac 660 cgtcaggaga aggcctgcca tgaccttggg cactgtcact gtggacagac aggcatccag 720 ggaggagaga tgccccagga agtggtacat aggggagcag aggtgaggct cagagcccac 780 agttatgaga atgaggagat tcccagtcaa ggcgatgctg tagatgagga ggaagagaag 840 gaagaagagg ccaggatgtt cagctgtata catgagaccc tccaggaaga agtggctcag 900 cacagcctgg ttgggggcct ctgtctccat 930

<210> 3158 <211> 183 <212> PRT <213> Felis catus <400> 3158

Met Glu Thr Glu Ala Pro Asn Gln Ala Val Leu Ser His Phe Phe Leu 1 5 10 15

Page 3526

Glu Gly Leu Met 20 Tyr Thr Ala 069269_0225_SL.TXT Glu His Pro Gly Leu Phe 25 Phe 30 Leu Leu Phe Leu Leu Ile Tyr Ser Ile Ala Leu Thr Gly Asn Leu Leu Ile Leu 35 40 45 Ile Thr Val Gly Ser Glu Pro His Leu Cys Ser Pro Met Tyr His Phe 50 55 60 Leu Gly His Leu Ser Ser Leu Asp Ala Cys Leu Ser Thr Val Thr Val 65 70 75 80 Pro Lys Val Met Ala Gly Leu Leu Leu Thr Val His Gly Lys Val Ile 85 90 95 Ser Ser Glu Gly Cys Ala Val Gln Leu Tyr Cys Phe Arg Phe Leu Ala 100 105 110 Ser Thr Glu Tyr Phe Leu Tyr Ala Ile Thr Ala Tyr Asp Arg Tyr Leu 115 120 125 Ala Ile Cys Gln Pro Leu His Tyr Pro Gly Gly His Glu Gln Thr Asp 130 135 140 Val Cys Arg Ala Gly Trp Asp His Leu Gly His Arg Cys Trp Ala Leu 145 150 155 160 Cys Arg Pro His Arg Pro His Leu Ser Pro Ala Leu Leu Trp Ser Ser 165 170 175 Pro His Arg Pro Leu Leu Leu

180 <210> 3159 <211> 936 <212> DNA <213> Felis catus <400> 3159 tcagtgaggc agcacatcct tgcgacctcc cagcctccac aatgctgcct tcatctcttt

Page 3527

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gttgcggagc gtgtagacga tggggttaag caagggggtg atgacagtgt agaagacggc 120 gaccactcca tccagggttt cctgagagcc agggcgaagg taaatgaagg tgcagggcac 180 atagtaaaca atgacaacag tgaggtgggc agcacaggtg gagaaggcgt tgcggcgccc 240 atcagcggac tggattcgca ggatggcagc cactatatac ccataggaag tgaggatgag 300 catgaagcag gtgagggcca agaacccaat gtccacaaag gtgaccagct cattgacggt 360 gatatcagca caggctagac gcaacatggc gggaatgtca cagaagaagt agtctacctg 420 gtttgggcca cagaagggca gccggaatat gaagcttgtt tggaaaagtg agtggagggt 480 acctcccagc caggtgccca aggccaggta attacagacg ttccgggtca tgatggtggc 540 ataatgtaaa ggcttacaga tggccaagaa gcgatcataa gccatgagcg tgtaaaggaa 600 gcattcagta cagcccagga aatggaaaga aaagagttgg attacacagc ctccaaagga 660 gatgaccctg ctatccaaga caaagccagc tagcatcttg gggacaatgg cagaggaaac 720 ggtcatgtcc aggaaggaga gatgacacag gaaccagtac atggggcggt gaagccgggt 780 gtccaccaag acagtgaaga tgatgagccc gttgccagag acagtgaggg catagatgac 840 caggaaagcc aggaagagcg gcacccccag ctgcggtggg tggtgcaggc ccaccaaaat 900 gaagtgagac acagaagtct ggtttccact gtgcat 936

<210> 3160 <211> 311 <212> PRT <213> Felis catus <400> 3160

Met His Ser Gly Asn Gln Thr Ser Val Ser His Phe Ile Leu Val Gly 1 5 10 15 Leu His His Pro Pro Gln Leu Gly Val Pro Leu Phe Leu Ala Phe Leu 20 25 30 Val Ile Tyr Ala Leu Thr Val Ser Gly Asn Gly Leu Ile Ile Phe Thr 35 40 45 Val Leu Val Asp Thr Arg Leu His Arg Pro Met Tyr Trp Phe Leu Cys 50 55 60

Page 3528

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His 65 Leu Ser Phe Leu Asp Met Thr Val Ser Ser Ala Ile Val Pro Lys 70 75 80 Met Leu Ala Gly Phe Val Leu Asp Ser Arg Val Ile Ser Phe Gly Gly 85 90 95 Cys Val Ile Gln Leu Phe Ser Phe His Phe Leu Gly Cys Thr Glu Cys 100 105 110 Phe Leu Tyr Thr Leu Met Ala Tyr Asp Arg Phe Leu Ala Ile Cys Lys 115 120 125 Pro Leu His Tyr Ala Thr Ile Met Thr Arg Asn Val Cys Asn Tyr Leu 130 135 140 Ala Leu Gly Thr Trp Leu Gly Gly Thr Leu His Ser Leu Phe Gln Thr 145 150 155 160 Ser Phe Ile Phe Arg Leu Pro Phe Cys Gly Pro Asn Gln Val Asp Tyr 165 170 175 Phe Phe Cys Asp Ile Pro Ala Met Leu Arg Leu Ala Cys Ala Asp Ile 180 185 190 Thr Val Asn Glu Leu Val Thr Phe Val Asp Ile Gly Phe Leu Ala Leu 195 200 205 Thr Cys Phe Met Leu Ile Leu Thr Ser Tyr Gly Tyr Ile Val Ala Ala 210 215 220 Ile Leu Arg Ile Gln Ser Ala Asp Gly Arg Arg Asn Ala Phe Ser Thr 225 230 235 240 Cys Ala Ala His Leu Thr Val Val Ile Val Tyr Tyr Val Pro Cys Thr 245 250 255 Phe Ile Tyr Leu Arg Pro Gly Ser Gln Glu Thr Leu Asp Gly Val Val 260 265 270

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069269_0225_SL.TXT

Ala Val Phe Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Ile Val Tyr 275 280 285 Thr Leu Arg Asn Lys Glu Met Lys Ala Ala Leu Trp Arg Leu Gly Gly 290 295 300 Arg Lys Asp Val Leu Pro His 305 310

<210> 3161 <211> 936 <212> DNA <213> Felis catus <400> 3161 atgagaaaca tgagcgtagt gacaacgttc atcctcacgg gtcttcccca tgcaccagca 60 ctggacatcc ccctcttggg aatcttcttg gtgatttatg tactcactgt ggtggagaac 120 ctcctcatcc tgctggtgat cacggtggat tcccacctcc acactcccat gtactatttc 180 ctggccaact tgtccttcat cgacatgtgg ttctccaccg tcactgtgcc caaaatgctg 240 atgaccttgg tctccccggg aggcggggcc atctcctttc acagctgtgt ggcccagctc 300 tactcctttc acttcctggg gagcaccgag tgtttcctct acacagtcat gtcctacgac 360 cgctacctgg ccatcagtca gccgctcagg tatgccagcc tgatgggtgg gagagcgtgt 420 gccctcctgg ccgccaccac gtggctcagc ggctctctgc actctgctgt ccagaccaca 480 ctgaccttcc gcttgcccta ctgtgggccc agccagatcc agcattattt ctgtgacgga 540 ccacccatcc tcagactggc ctgtgcagac acgtccatga acgagagggt gatcttcgtc 600 aacatcgggg tagtggcttc gggctgcttt ctcctgatag tggggtccta tgtgtccatc 660 gtctgttcca tcctgaagat ccgcacctcc gaggggagat gcagagcctt tcagacctgt 720 acctcccact gcattgtggt cctttgtttc tttgttccct gtgtttttgt ttacctgagg 780 ccaggctcca aggatgctgt ggacaggatt gtggcagttt tctacactgt gctgactccc 840 cttctaaacc ctgtggtgta caccctgagg aataaggaag tgaagaaagc tctattgaag 900 cttcaagaca aagtaacata gtctcagaga aaataa 936

Page 3530

069269_0225_SL.TXT <210> 3162 <211> 306 <212> PRT <213> Felis catus

<400> 3162 Met 1 Arg Asn Met Ser Val Val Thr 5 Thr Phe 10 Ile Leu Thr Gly Leu Pro 15 His Ala Pro Ala Leu Asp Ile Pro Leu Leu Gly Ile Phe Leu Val Ile 20 25 30 Tyr Val Leu Thr Val Val Glu Asn Leu Leu Ile Leu Leu Val Ile Thr 35 40 45 Val Asp Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Ala Asn Leu 50 55 60 Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu 65 70 75 80 Met Thr Leu Val Ser Pro Gly Gly Gly Ala Ile Ser Phe His Ser Cys 85 90 95 Val Ala Gln Leu Tyr Ser Phe His Phe Leu Gly Ser Thr Glu Cys Phe 100 105 110 Leu Tyr Thr Val Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser Gln Pro 115 120 125 Leu Arg Tyr Ala Ser Leu Met Gly Gly Arg Ala Cys Ala Leu Leu Ala 130 135 140 Ala Thr Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Thr 145 150 155 160 Leu Thr Phe Arg Leu Pro Tyr Cys Gly Pro Ser Gln Ile Gln His Tyr 165 170 175 Phe Cys Asp Gly Pro Pro Ile Leu Arg Leu Ala Cys Ala Asp Thr Ser 180 185 190

Page 3531

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Met Asn Glu Arg Val Ile 195 Phe Val Asn Ile Gly Val Val Ala Ser Gly 200 205 Cys Phe Leu Leu Ile Val Gly Ser Tyr Val Ser Ile Val Cys Ser Ile 210 215 220 Leu Lys Ile Arg Thr Ser Glu Gly Arg Cys Arg Ala Phe Gln Thr Cys 225 230 235 240 Thr Ser His Cys Ile Val Val Leu Cys Phe Phe Val Pro Cys Val Phe 245 250 255 Val Tyr Leu Arg Pro Gly Ser Lys Asp Ala Val Asp Arg Ile Val Ala 260 265 270 Val Phe Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr 275 280 285 Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Leu Lys Leu Gln Asp Lys 290 295 300

Val Thr 305 <210> 3163 <211> 928 <212> DNA <213> Felis catus <400> 3163

attcggtgaa tactgactta cttctcacct tgaacagagc tttcttcact tccttgttcc 60 tcagggtgta caccacaggg tttagaaggg gagtcagcac agtgtagaaa actgccacaa 120 tcctgtccac agcatccttg gagcctggcc tcaggtaaac aaaaacacag ggaacaaaga 180 aacaaaggac cacaatgcag tgggaggtac aggtctgaaa ggctctgcat ctcccctcgg 240 aggtgcggat cttcaggatg gaacagacga tggacacata ggacagcact atcaggagaa 300 agcagctcaa ggccactact ccgatgttga cgaagatcac cctctcgttc atggacgtgt 360

Page 3532

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ctgcacaggc cagtctgagg ataggaggag cgtcacagaa ataatgctgg atctggctgg 420 gcccacagta gggcaagcgg aaggtcagtg tggtctggac agcagagtgc agagagccgc 480 tgagccacgt ggtggcggcc aggagggcac acgctctccc acccatcagg ctggcatacc 540 tgagcggctg actgatggcc aggtagcggt cgtaggacat gactgtgtag aggaaacact 600 cggtgctccc caggaagtga aaggagtaga gctgggccac acagctgtga aaggagatgg 660 ccccgcctcc cggggagacc aaggtcatca gcattttggg cacagtgacg gtggagaacc 720 acatgtcgat gaaggacaag ttggccagga aatagtacat gggagtgtgg aggtgggaat 780 ccaccgtgat caccagcagg atgaggaggt tccccaccac agtgagtaca taaatcacca 840 agaagattcc caagaggggg atgtccagtg ctggtgcatg gggaagaccc gtgaggatga 900 acgttgtcac tacgctcatg tttctcat 928

<210> 3164 <211> 310 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (310)..(310) <223> Any amino acid <400> 3164

Met Arg Asn Met Ser Val Val Thr Thr Phe Ile Leu Thr Gly Leu Pro 1 5 10 15 His Ala Pro Ala Leu Asp Ile Pro Leu Leu Gly Ile Phe Leu Val Ile 20 25 30 Tyr Val Leu Thr Val Val Gly Asn Leu Leu Ile Leu Leu Val Ile Thr 35 40 45 Val Asp Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Ala Asn Leu 50 55 60 Ser Phe Ile Asp Met Trp Phe Ser Thr Val Thr Val Pro Lys Met Leu 65 70 75 80

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Met Thr Leu Val Ser 85 Pro Gly Gly Gly Ala Ile Ser Phe His Ser Cys 90 95 Val Ala Gln Leu Tyr Ser Phe His Phe Leu Gly Ser Thr Glu Cys Phe 100 105 110 Leu Tyr Thr Val Met Ser Tyr Asp Arg Tyr Leu Ala Ile Ser Gln Pro 115 120 125 Leu Arg Tyr Ala Ser Leu Met Gly Gly Arg Ala Cys Ala Leu Leu Ala 130 135 140 Ala Thr Thr Trp Leu Ser Gly Ser Leu His Ser Ala Val Gln Thr Thr 145 150 155 160 Leu Thr Phe Arg Leu Pro Tyr Cys Gly Pro Ser Gln Ile Gln His Tyr 165 170 175 Phe Cys Asp Ala Pro Pro Ile Leu Arg Leu Ala Cys Ala Asp Thr Ser 180 185 190 Met Asn Glu Arg Val Ile Phe Val Asn Ile Gly Val Val Ala Leu Ser 195 200 205 Cys Phe Leu Leu Ile Val Leu Ser Tyr Val Ser Ile Val Cys Ser Ile 210 215 220 Leu Lys Ile Arg Thr Ser Glu Gly Arg Cys Arg Ala Phe Gln Thr Cys 225 230 235 240 Thr Ser His Cys Ile Val Val Leu Cys Phe Phe Val Pro Cys Val Phe 245 250 255 Val Tyr Leu Arg Pro Gly Ser Lys Asp Ala Val Asp Arg Ile Val Ala 260 265 270 Val Phe Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Val Val Tyr Thr 275 280 285

Page 3534

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Leu Arg Asn Lys Glu Val Lys Lys Ala Leu Phe Lys Val Arg Ser Lys 290 295 300

Ser Val Phe Thr Glu Xaa

305 310 <210> 3165 <211> 927 <212> DNA <213> Felis catus <400> 3165

atgcagaact acacttctgt gacggagttc accctgttgg gaattccaaa tactgaaggg 60 ctggagaata tgctgtttgt cctctttctg gccttctacc tcttcacctt gctggggaac 120 ctgctcatct tcctcaccat tctggtttcc tctaacctgc acacccccat gtatttcttc 180 ctgggaaacc tgtctgtgtt tgacatattt ttcccttcag tgagttcccc caaaatgatg 240 ctctacctaa cggggccaag ccggaccatc tcttaccagg gctgtgcctg ccagctcttc 300 ttctaccact tcctgggtgg cactgagtgc ttcctgtaca cggtgatggc ctatgaccgc 360 ttcgtggcta tttgtcaccc tttgcgatac acagtcatca tgagccacag ggtgcgtacc 420 ggcttgatgt tgggcacttg gctgggcggc tgtctacatg gaagtatcct cacgtttctg 480 gtctttaagt tacccttctg tggccccaat gaggtggata atttcttctg tgatatccca 540 gggctgctgc cgctggcctg tgcagacacc tctctagccc agaccgtgag ttttactaac 600 gtggatgttg tgactctgac atgctttttc cttatcctta cttcctacgg ccacatcgtc 660 atttccatac tgaaaatcgg cacctctgca ggcaggcgcc gagctttttc cacctgcagt 720 gcccacctga tatcaatctt cttgttttac ggtccagtga tgctcatcta tctcaggccc 780 gcttccagcc cctggctaga ttctgttatt caggtgttaa ataacattgt cactccttct 840 cttaaccctt tgatttacac cttgagaaac aaggatgtga aattggcctt gaggcaagta 900 ttcactcaag tggtccacat ttctggg 927

<210> 3166 <211> 309 <212> PRT <213> Felis catus

Page 3535

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<400> 3166 Thr Ser Val Thr Glu Phe Thr Leu Leu Gly Ile Pro 15 Met 1 Gln Asn Tyr 5 10 Asn Thr Glu Gly Leu Glu Asn Met Leu Phe Val Leu Phe Leu Ala Phe 20 25 30 Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Phe Leu Thr Ile Leu 35 40 45 Val Ser Ser Asn Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu 50 55 60 Ser Val Phe Asp Ile Phe Phe Pro Ser Val Ser Ser Pro Lys Met Met 65 70 75 80 Leu Tyr Leu Thr Gly Pro Ser Arg Thr Ile Ser Tyr Gln Gly Cys Ala 85 90 95 Cys Gln Leu Phe Phe Tyr His Phe Leu Gly Gly Thr Glu Cys Phe Leu 100 105 110 Tyr Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu 115 120 125 Arg Tyr Thr Val Ile Met Ser His Arg Val Arg Thr Gly Leu Met Leu 130 135 140 Gly Thr Trp Leu Gly Gly Cys Leu His Gly Ser Ile Leu Thr Phe Leu 145 150 155 160 Val Phe Lys Leu Pro Phe Cys Gly Pro Asn Glu Val Asp Asn Phe Phe 165 170 175 Cys Asp Ile Pro Gly Leu Leu Pro Leu Ala Cys Ala Asp Thr Ser Leu 180 185 190 Ala Gln Thr Val Ser Phe Thr Asn Val Asp Val Val Thr Leu Thr Cys 195 200 205

Page 3536

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Phe Phe Leu Ile Leu Thr Ser Tyr Gly His Ile Val Ile Ser Ile Leu 210 215 220 Lys Ile Gly Thr Ser Ala Gly Arg Arg Arg Ala Phe Ser Thr Cys Ser 225 230 235 240 Ala His Leu Ile Ser Ile Phe Leu Phe Tyr Gly Pro Val Met Leu Ile 245 250 255 Tyr Leu Arg Pro Ala Ser Ser Pro Trp Leu Asp Ser Val Ile Gln Val 260 265 270 Leu Asn Asn Ile Val Thr Pro Ser Leu Asn Pro Leu Ile Tyr Thr Leu 275 280 285 Arg Asn Lys Asp Val Lys Leu Ala Leu Arg Gln Val Phe Thr Gln Val 290 295 300 Val His Ile Ser Gly

305

<210> 3167 <211> 936 <212> DNA <213> Felis catus <400> 3167 tcatttattc ttcacagaga agcctctcct gtgaaatata ttccaaaggg ctgatttcac 60 atccttattc ctcaggctgt agattagtgg gttcagcgtg ggggtaacaa gattgttcac 120 tatctgaatt attgcgccaa gcaaggcgct gggattgggc tgtaggtaga tgatgattac 180 cggtccataa gcacaaagaa ttgcagtgag gtgggcactg caggtggaga aggctctttg 240 cctgccctct gctgagcgaa tttttgatat ggagatccca atgcgagtgt aggaaacaag 300 gatgacaaaa aagcaaacga gagacaaaag accaacattt gtaaaaccaa ccctctgggc 360 tagagctata tcaccacagg ccagaggtaa gacggcaggt atgtcacaga agtagtagcc 420 cacctggtta gagtcacagt agggcaactg gaaagtgagg gaggttagaa taatggcgtg 480

Page 3537

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aacacagcca cccgtccagg tccctgtggc caagatggag cagaccctgc ggttcatgat 540 gaccatgtat ctcaaaggat aacatatggc aacaaagcgg tcataggcca tcactgtgta 600 caggaaacac tcagtgcagc ccaggaagtg gtagaagaag acctgggaca cacagccctg 660 aaaagagata ccccgactct gccctgaaag gtataacagc atcttgggaa cagtggttga 720 agagaagccc aggtcaaaca tggagagatt tcccaagaaa aaatacatag gagtgtgaag 780 ccgagaggag gagatgatag ctgtgaggat gagcacattt cccaagagag tacacaaata 840 taatgacaag aacaggaaaa aaaggacagt ctctaggccc tctgtctccg ggattccaag 900 caggatgaat tcagttaccg ttgtgtgatt tctcat 936 <210> 3168 <211> 311 <212> PRT <213> Felis catus <400> 3168 Met Arg Asn His Thr Thr Val Thr Glu Phe Ile Leu Leu Gly Ile Pro 1 5 10 15 Glu Thr Glu Gly Leu Glu Thr Val Leu Phe Phe Leu Phe Leu Ser Leu 20 25 30 Tyr Leu Cys Thr Leu Leu Gly Asn Val Leu Ile Leu Thr Ala Ile Ile 35 40 45 Ser Ser Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu 50 55 60 Ser Met Phe Asp Leu Gly Phe Ser Ser Thr Thr Val Pro Lys Met Leu 65 70 75 80 Leu Tyr Leu Ser Gly Gln Ser Arg Gly Ile Ser Phe Gln Gly Cys Val 85 90 95 Ser Gln Val Phe Phe Tyr His Phe Leu Gly Cys Thr Glu Cys Phe Leu 100 105 110 Tyr Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Tyr Pro Leu

Page 3538

115 069269_0225_SL.TXT 120 125 Arg Tyr Met Val Ile Met Asn Arg Arg Val Cys Ser Ile Leu Ala Thr 130 135 140 Gly Thr Trp Thr Gly Gly Cys Val His Ala Ile Ile Leu Thr Ser Leu 145 150 155 160 Thr Phe Gln Leu Pro Tyr Cys Asp Ser Asn Gln Val Gly Tyr Tyr Phe 165 170 175 Cys Asp Ile Pro Ala Val Leu Pro Leu Ala Cys Gly Asp Ile Ala Leu 180 185 190 Ala Gln Arg Val Gly Phe Thr Asn Val Gly Leu Leu Ser Leu Val Cys 195 200 205 Phe Phe Val Ile Leu Val Ser Tyr Thr Arg Ile Gly Ile Ser Ile Ser 210 215 220 Lys Ile Arg Ser Ala Glu Gly Arg Gln Arg Ala Phe Ser Thr Cys Ser 225 230 235 240 Ala His Leu Thr Ala Ile Leu Cys Ala Tyr Gly Pro Val Ile Ile Ile 245 250 255 Tyr Leu Gln Pro Asn Pro Ser Ala Leu Leu Gly Ala Ile Ile Gln Ile 260 265 270 Val Asn Asn Leu Val Thr Pro Thr Leu Asn Pro Leu Ile Tyr Ser Leu 275 280 285 Arg Asn Lys Asp Val Lys Ser Ala Leu Trp Asn Ile Phe His Arg Arg 290 295 300 Gly Phe Ser Val Lys Asn Lys 305 310

<210> 3169

Page 3539

069269_0225_SL.TXT <211> 840 <212> DNA <213> Felis catus <400> 3169

tgtttcttaa gaaatagatt aacgagttca gcatgggtga gacaatatta tttaatattt 60 acaccacagc accaagcaag gggttgggtg agggctgcag atagatgatg attacaggtc 120 cataggcaca gaggattgcg gtgaggtggg cactgcaggt agagaaagct ttctgcccgc 180 cctctgctga tcggattctc agaatggcaa tcccaatgca tgtgtaggag atacagacac 240 tgaaccaaag cattaaagcc agaaaaccat tagtggagcc cactttctgg gccagggagc 300 tgtcagtaca cgccaggggt aagacagcag gaatgtcaca gaagtactcc acccggttgg 360 agccacagta ggttaaccga aaggtgaagg aggtcaggat ggtggcgtgg agacaagcca 420 ccagccaggc tgccatgact aagctgacac agacctcagt gggtgacaga tggccacaaa 480 gcggtcatag gccatcacag aatagagaca accttcgcta gaccccagga aatggtagaa 540 gaagagctgt gcagcacagc ccttataaga aagggcttgg gtttggccag agagataaaa 600 tagcatcctg ggacaggtta tagatgggaa caacgtgtcg aaaatagata ggcgtcccag 660 aaagaaatac atgggggtgt gaagggtaga ggaagaaaca attgctgtaa ggatgagtaa 720 attgccaagc agggtgaaga ggtaagcaaa tgagaagatg acaaatagca cagtctccag 780 tccctctgtc tgaggtattc ccagtagaat aaactcctgg aactctgtgt gattcctcat 840

<210> 3170 <211> 133 <212> PRT <213> Felis catus <400> 3170

Met 1 Arg Asn His Thr Glu Phe Gln Glu Phe Ile Leu Leu Gly Ile Pro 5 10 15 Gln Thr Glu Gly Leu Glu Thr Val Leu Phe Val Ile Phe Ser Phe Ala 20 25 30 Tyr Leu Phe Thr Leu Leu Gly Asn Leu Leu Ile Leu Thr Ala Ile Val 35 40 45

Page 3540

Ser Ser 50 Ser Thr Leu His Thr 55 069269_0225_SL.TXT Pro Met Tyr Phe Phe Leu 60 Gly Arg Leu Ser Ile Phe Asp Thr Leu Phe Pro Ser Ile Thr Cys Pro Arg Met Leu 65 70 75 80 Phe Tyr Leu Ser Gly Gln Thr Gln Ala Leu Ser Tyr Lys Gly Cys Ala 85 90 95 Ala Gln Leu Phe Phe Tyr His Phe Leu Gly Ser Ser Glu Gly Cys Leu 100 105 110 Tyr Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu 115 120 125 Arg Ser Val Ser Ala

130 <210> 3171 <211> 935 <212> DNA <213> Felis catus <400> 3171

atgaagaatc tctcagcagt gactgagttc atcctgctgg gcatcccaca cacggaagac 60 ctggagacca tgctctttgt cctgtttttg ggctgctacg tcttcactct tatggggaac 120 ctgctcatcc tactggcgat tgtctcctcc actcggcttc acacccccat gtacttcttc 180 ctgtgtcaac tgtctgtgtg tgacatattt ttcccttctg tgagctcccc caagatgctc 240 ttctacctct cggggaacag ccgggccatc tcctatgcgg gctgcgtgtc ccagctcttc 300 ttctaccact tcctgggctg taccgagtgc ttcctgtaca cggtgatggc ctacgaccgc 360 tttgtcgcca tctgctaccc tctccgctac acggtaatca tgagccacag ggtgtgtgcc 420 atcctggccg tggggacctc tttttttggc tgcgttcagg ccaccttcct aaccactctc 480 accttccagt tgccctactg tggccccaat gaggtggatt acttcttctg tgatatcccg 540 gtgatgctga agctggcttg tgctgacacc tcagccctgg agagggtggg gttcgtcagc 600 gtgggcctca tgcccctcag ctgcttcctt ctcatcctca cctcctacag ccgcattgtc 660

Page 3541

069269_0225_SL.TXT tgctccatcc tgcagatccg ctctaccgaa ggcagacgcc gtgccttctc cacctgcagt gcccacctca ccgccatcct gcttttctac atgccggtgg tcctcatcta cctcaggccc accccaagcc cctggctgga tgcaactgtt cagatcctga ataacctggt cacccccatg ctgaacccct tgatttacag cctcaggaac aaggaagtaa tatcctctct ggggaaggtg ctacatcact tgggcttcct tgctgaccaa ttgta

720

780

840

900

935 <210> 3172 <211> 312 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (312)..(312) <223> Any amino acid <400> 3172

Met 1 Lys Asn Leu Ser 5 Ala Val Thr Glu Phe Ile Leu Leu Gly Ile Pro 10 15 His Thr Glu Asp Leu Glu Thr Met Leu Phe Val Leu Phe Leu Gly Cys 20 25 30 Tyr Val Phe Thr Leu Met Gly Asn Leu Leu Ile Leu Leu Ala Ile Val 35 40 45 Ser Ser Thr Arg Leu His Thr Pro Met Tyr Phe Phe Leu Cys Gln Leu 50 55 60 Ser Val Cys Asp Ile Phe Phe Pro Ser Val Ser Ser Pro Lys Met Leu 65 70 75 80 Phe Tyr Leu Ser Gly Asn Ser Arg Ala Ile Ser Tyr Ala Gly Cys Val 85 90 95 Ser Gln Leu Phe Phe Tyr His Phe Leu Gly Cys Thr Glu Cys Phe Leu 100 105 110 Tyr Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Tyr Pro Leu Page 3542

115 069269_0225_SL.TXT 120 125 Arg Tyr Thr Val Ile Met Ser His Arg Val Cys Ala Ile Leu Ala Val 130 135 140 Gly Thr Ser Phe Phe Gly Cys Val Gln Ala Thr Phe Leu Thr Thr Leu 145 150 155 160 Thr Phe Gln Leu Pro Tyr Cys Gly Pro Asn Glu Val Asp Tyr Phe Phe 165 170 175 Cys Asp Ile Pro Val Met Leu Lys Leu Ala Cys Ala Asp Thr Ser Ala 180 185 190 Leu Glu Arg Val Gly Phe Val Ser Val Gly Leu Met Pro Leu Ser Cys 195 200 205 Phe Leu Leu Ile Leu Thr Ser Tyr Ser Arg Ile Val Cys Ser Ile Leu 210 215 220 Gln Ile Arg Ser Thr Glu Gly Arg Arg Arg Ala Phe Ser Thr Cys Ser 225 230 235 240 Ala His Leu Thr Ala Ile Leu Leu Phe Tyr Met Pro Val Val Leu Ile 245 250 255 Tyr Leu Arg Pro Thr Pro Ser Pro Trp Leu Asp Ala Thr Val Gln Ile 260 265 270 Leu Asn Asn Leu Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu 275 280 285 Arg Asn Lys Glu Val Ile Ser Ser Leu Gly Lys Val Leu His His Leu 290 295 300 Gly Phe Leu Ala Asp Gln Leu Xaa 305 310

<210> 3173

Page 3543

069269_0225_SL.TXT <211> 926 <212> DNA <213> Felis catus <400> 3173

agaagaattg ctcaggggtg accgaattca tcctgttggg aattccacac acagaggggt 60 tggagactat agtttttgtc ttgttcttgc ccttctatgc ctgcaccctg ctgggaaatg 120 tgtctatcct cgtggctgtt ctttcttcca cttgccttca tgcgcccatg tattttttct 180 tggggaactt gtctgttttt gacatgagtt tctcttctgt gacctgtcct aaaatgccac 240 tgtaccttat gggccccctc attttgtata agatctagtc tcccaggtct ccttcttcca 300 tttccttggc agcattgaat gcttcttgta tactgtgatg gcctatggcc actttgctgc 360 tatctgttac cctctatggt aggcagccat catgaaccgt agactcggtg gggccctggc 420 tgtgggcaca tgggtgttgg ggtatatcca ttccagcatt ttgactttgc tcaccttcac 480 tttgccatgc tgcggtccca ataagtggac cacttcttct gtgatattcc agcactcctg 540 ccattggcct gtgctgatac atccttagcc cagagggtgg gtttcaccaa tgttggcttg 600 gtatctctcc tctgcttgtt tctaatcctt ctatcctaca ctcgcgtcac catctccatc 660 ttgtatattc gttcaaccga gggccgccgc cgggccttct ccacttgcag tgcccacctc 720 attgccatcc tttgtgccta tgggcccatc atcactgtct acctgcagcc caccccaacc 780 ccatgctggg aactgaggtt caaattctga tgaatctcgt aggaccaagg ctgaaccttt 840 taatctatac cttgaggaat aaggaagtta aaacagccct gaaaacaatt ttgcacagga 900 caaaccacgt ttctgagaga tagtaa 926

<210> 3174 <211> 91 <212> PRT <213> Felis catus <400> 3174

Lys Asn Cys Ser Gly Val Thr Glu Phe Ile Leu Leu Gly Ile Pro His 1 5 10 15

Thr Glu Gly Leu Glu Thr Ile Val Phe Val Leu Phe Leu Pro Phe Tyr 20 25 30

Page 3544

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Ala Cys Thr Leu Leu Gly Asn Val Ser Ile Leu Val Ala Val Leu Ser 35 40 45 Ser Thr Cys Leu His Ala Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser 50 55 60 Val Phe Asp Met Ser Phe Ser Ser Val Thr Cys Pro Lys Met Pro Leu 65 70 75 80 Tyr Leu Met Gly Pro Leu Ile Leu Tyr Lys Ile

85 90 <210> 3175 <211> 946 <212> DNA <213> Felis catus <400> 3175

agcaggaaat cattccacag tgactgagtt catccttgct gggttaacag agagcccaga 60 actccagctg ccccttttct tcctcttcct aggagtctat gtggtcacgg tggtggggaa 120 cctggccatg atcacactga tagggctcag tgctcacctg cacaccccca tgtactattt 180 cctcagcaat ttgtccttca ttgatctctg ccattccact gtcattaccc ctaaaatgct 240 agtgaacttt gtgacagaga ggaatttcat ctcctaccaa gcatgcatga ctcaactcta 300 cttcttcctt gtttttgtta tatcagaatg tcatatgttg gctataatgg cgtatgatcg 360 ctatgttgcc atctgtaacc cattgcttta caatgtcacc atgtcttatc aggtttgctc 420 ccggctggta gttggggtgt atatcatggg cttgactggt gcctcagctc acacaggctg 480 catgctaaga gtgcttttct gtaaggctga cagaatcaac cattacttct gtgatctttt 540 cccactgttg gagctctcct gctccagtac ttatatcaac gaggtggtag ttttgtgctt 600 cagtgcattt aatatcctcg cccccagcct catgattctt agctcctaca tcttcatcat 660 tgccagcatc ctccgcatcc gctccaccga aggtaggtgc aaagccttca gcacctgcag 720 ctcccacatc tcagctgttg ccgttttctt tggatccgct gcgttcatgt acctgcagcc 780 atcatctgtg agctccatga accaagggaa agtgtcttcc gtgttttaca ccattattgt 840 gcctatgctg aaccccctga tctacagcct gaggaataaa gatgtcagag ttgtcctgaa 900

Page 3545

946

069269_0225_SL.TXT taagatcctt gaaaaaagaa ggaaatgggt attttgcttg agaaaa <210> 3176 <211> 315 <212> PRT <213> Felis catus <400> 3176

Ala 1 Gly Asn His Ser Thr Val Thr Glu Phe Ile Leu Ala Gly Leu Thr 5 10 15 Glu Ser Pro Glu Leu Gln Leu Pro Leu Phe Phe Leu Phe Leu Gly Val 20 25 30 Tyr Val Val Thr Val Val Gly Asn Leu Ala Met Ile Thr Leu Ile Gly 35 40 45 Leu Ser Ala His Leu His Thr Pro Met Tyr Tyr Phe Leu Ser Asn Leu 50 55 60 Ser Phe Ile Asp Leu Cys His Ser Thr Val Ile Thr Pro Lys Met Leu 65 70 75 80 Val Asn Phe Val Thr Glu Arg Asn Phe Ile Ser Tyr Gln Ala Cys Met 85 90 95 Thr Gln Leu Tyr Phe Phe Leu Val Phe Val Ile Ser Glu Cys His Met 100 105 110 Leu Ala Ile Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 115 120 125 Leu Tyr Asn Val Thr Met Ser Tyr Gln Val Cys Ser Arg Leu Val Val 130 135 140 Gly Val Tyr Ile Met Gly Leu Thr Gly Ala Ser Ala His Thr Gly Cys 145 150 155 160 Met Leu Arg Val Leu Phe Cys Lys Ala Asp Arg Ile Asn His Tyr Phe 165 170 175

Page 3546

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Cys Asp Leu Phe Pro Leu Leu Glu Leu Ser Cys Ser Ser Thr Tyr Ile 180 185 190 Asn Glu Val Val Val Leu Cys Phe Ser Ala Phe Asn Ile Leu Ala Pro 195 200 205 Ser Leu Met Ile Leu Ser Ser Tyr Ile Phe Ile Ile Ala Ser Ile Leu 210 215 220 Arg Ile Arg Ser Thr Glu Gly Arg Cys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240 Ser His Ile Ser Ala Val Ala Val Phe Phe Gly Ser Ala Ala Phe Met 245 250 255 Tyr Leu Gln Pro Ser Ser Val Ser Ser Met Asn Gln Gly Lys Val Ser 260 265 270 Ser Val Phe Tyr Thr Ile Ile Val Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Arg Val Val Leu Asn Lys Ile Leu Glu 290 295 300 Lys Arg Arg Lys Trp Val Phe Cys Leu Arg Lys

305 310 315 <210> 3177 <211> 934 <212> DNA <213> Felis catus <400> 3177 atggaccctg gaaataattc cacagtaact gagttcatcc tcgctgggct aacagagaag accggattcc agctgcccct tttcttcctc ttcctaggag tctatgtggt cacggtggtg gggaacctgg ccatgatcac actgataggg ctcagggctc acctgcacac ccccatgtac tatttcctca gcaatttgtc cttcattgat ctctgtcatt ccactgtcat tacccccaaa atgctggtga actttgtgac tgagacgaac ataatttcct actcagcatg catgactcag

120

180

240

300

Page 3547

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ctctatttct tccttgtttt tgctatctca gagtgtcaca tgttagctgc aatggcttat 360 gaccgctatg ctaccatctg caaccccttg ctttacaatg tcgtcatgtc ttcacacatc 420 tgcttccggc tcacagtggg agtttatatt ttgggcatcg ttggatctac aatccatacg 480 ggttttatga tgaggctcct tttctgccag agcaatgtga ttaaccatta tttctgtgat 540 ctctttccac tcctggagat atcctgttcc agcatcttca tcaatgaatt attggtccta 600 gtcttgagtg catttaacat tctgactcct gccttcacca tccttgcctc ctacatcttc 660 atcattgcca gcatcctccg catccgctcc accgagggca ggtgcaaagc cttcaggacc 720 tgcagctccc acatctccgc tgttgccatt ttctttggat ctgctgcgtt catgtacctg 780 cagccatcat ctgtgagctc catggaccga gggagagtgt cctctgtgtt ttataccacc 840 attgtgccca tgctgaaccc cttgatctat agtctgcaga ataaggatgt caaatttgcc 900 ctgaagaaaa ttctgggcag tagaaaatgt tcat 934

<210> 3178 <211> 312 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (312)..(312) <223> Any amino acid <400> 3178

Met 1 Asp Pro Gly Asn Asn Ser Thr Val Thr Glu Phe Ile Leu Ala Gly 5 10 15 Leu Thr Glu Lys Thr Gly Phe Gln Leu Pro Leu Phe Phe Leu Phe Leu 20 25 30 Gly Val Tyr Val Val Thr Val Val Gly Asn Leu Ala Met Ile Thr Leu 35 40 45 Ile Gly Leu Arg Ala His Leu His Thr Pro Met Tyr Tyr Phe Leu Ser

50 55 60

Page 3548

Asn 65 Leu Ser Phe Ile Asp 70 Leu 069269_0225_SL.TXT Cys His Ser Thr Val Ile 75 Thr Pro Lys 80 Met Leu Val Asn Phe Val Thr Glu Thr Asn Ile Ile Ser Tyr Ser Ala 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Leu Val Phe Ala Ile Ser Glu Cys 100 105 110 His Met Leu Ala Ala Met Ala Tyr Asp Arg Tyr Ala Thr Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Val Met Ser Ser His Ile Cys Phe Arg Leu 130 135 140 Thr Val Gly Val Tyr Ile Leu Gly Ile Val Gly Ser Thr Ile His Thr 145 150 155 160 Gly Phe Met Met Arg Leu Leu Phe Cys Gln Ser Asn Val Ile Asn His 165 170 175 Tyr Phe Cys Asp Leu Phe Pro Leu Leu Glu Ile Ser Cys Ser Ser Ile 180 185 190 Phe Ile Asn Glu Leu Leu Val Leu Val Leu Ser Ala Phe Asn Ile Leu 195 200 205 Thr Pro Ala Phe Thr Ile Leu Ala Ser Tyr Ile Phe Ile Ile Ala Ser 210 215 220 Ile Leu Arg Ile Arg Ser Thr Glu Gly Arg Cys Lys Ala Phe Arg Thr 225 230 235 240 Cys Ser Ser His Ile Ser Ala Val Ala Ile Phe Phe Gly Ser Ala Ala 245 250 255 Phe Met Tyr Leu Gln Pro Ser Ser Val Ser Ser Met Asp Arg Gly Arg 260 265 270

Page 3549

06926 9_02 25_S iL.TX T Val Ser Ser Val Phe Tyr Thr Thr Ile Val Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Gln Asn Lys Asp Val Lys Phe Ala Leu Lys Lys Ile 290 295 300 Leu Gly Ser Arg Lys Cys Ser Xaa 305 310

<210> 3179 <211> 936 <212> DNA <213> Felis catus <400> 3179

atggcagcag aaaatctttc cacagtgact gcgtttatcc tcactgggct aacacaacag 60 ccagaactcc agctgcccct tttctttctc ttcctaggag tctatgtggt cacagtggtg 120 gggaacttgg tcatgatcac actgatagga ctcagtgctc acctacacac ccccatgtac 180 tacttcctca gtaatttgtc cttcattgat ctctgccatt ccactgtcat tacccccaaa 240 atgctagtga actttgtgac agagatggac accatctcct actctgaatg cataactcag 300 ctctatttct tccttgtttt tgctatctca gagtgttaca tgttagctgc aatggcatac 360 gaccgctatg ttgccatctg tagccccctg ctttataata tcaacatgtc ccatcaggct 420 tgtttctccc tgatttgggg agtgtatatt atagccctgg tttgtgcatt tgttcataca 480 gtctgcttgt ttagagttca cttctgcaaa tttgctgtga tcaaccatta tttctgtgat 540 cttctttccc tcttaaagct ctcctgttct agcacccacg tcaatgaatt actgattcta 600 gtctttagtg caattaatat cctcgccccc agcctcatga ttcttagctc ctacatcttc 660 atcattgcca gcatgctccg catccgctcc accgaaggca gagccaaagc cttcagcacc 720 tgcagctccc acatctcagc tgttgccgtt ttctttggat ccgctgcgtt catgtacctg 780 cagccatcat ctgtgagctc cctagaccga ggaaaagtgt cttctgtgtt ttatactgtt 840 gttgtgccta tgttgaatcc cctgatctac agcctgagga ataaagatgt caatgtcgca 900 ctgaagaaaa tgctagagag aagaatattc ttgtga 936

<210> 3180

Page 3550

069269_0225_SL.TXT <211> 311 <212> PRT <213> Felis catus

<400> 3180 Thr 15 Gly Met 1 Ala Ala Glu Asn Leu Ser Thr 5 Val Thr 10 Ala Phe Ile Leu Leu Thr Gln Gln Pro Glu Leu Gln Leu Pro Leu Phe Phe Leu Phe Leu 20 25 30 Gly Val Tyr Val Val Thr Val Val Gly Asn Leu Val Met Ile Thr Leu 35 40 45 Ile Gly Leu Ser Ala His Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys His Ser Thr Val Ile Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Val Thr Glu Met Asp Thr Ile Ser Tyr Ser Glu 85 90 95 Cys Ile Thr Gln Leu Tyr Phe Phe Leu Val Phe Ala Ile Ser Glu Cys 100 105 110 Tyr Met Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr Asn Ile Asn Met Ser His Gln Ala Cys Phe Ser Leu 130 135 140 Ile Trp Gly Val Tyr Ile Ile Ala Leu Val Cys Ala Phe Val His Thr 145 150 155 160 Val Cys Leu Phe Arg Val His Phe Cys Lys Phe Ala Val Ile Asn His 165 170 175 Tyr Phe Cys Asp Leu Leu Ser Leu Leu Lys Leu Ser Cys Ser Ser Thr 180 185 190

Page 3551

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His Val Asn 195 Glu Leu Leu Ile Leu 200 Ala Pro 210 Ser Leu Met Ile Leu 215 Ser Met 225 Leu Arg Ile Arg Ser 230 Thr Glu Cys Ser Ser His Ile 245 Ser Ala Val Phe Met Tyr Leu 260 Gln Pro Ser Ser Val Ser Ser 275 Val Phe Tyr Thr Val 280 Ile Tyr 290 Ser Leu Arg Asn Lys 295 Asp Leu 305 Glu Arg Arg Ile Phe 310 Leu

Val Phe Ser Ala Ile 205 Asn Ile Leu Ser Tyr Ile Phe 220 Ile Ile Ala Ser Gly Arg Ala 235 Lys Ala Phe Ser Thr 240 Ala Val 250 Phe Phe Gly Ser Ala 255 Ala Val 265 Ser Ser Leu Asp Arg 270 Gly Lys Val Val Pro Met Leu 285 Asn Pro Leu Val Asn Val Ala 300 Leu Lys Lys Met

<210> 3181 <211> 929 <212> DNA <213> Felis catus <400> 3181 atggggaatg cttcagtggt gaccaagttc ctggagacca tgctctttgt cctgtttttg ctgctcatcc tactggcgat tgtctcctcc ctgtgtcaac tgtctgtgtg tgacatattt ttctacctct cggggaacag ccgggccatc ttctaccact tcctgggctg taccgagtgc tttgttgcca tctgctaccc tctccgctac atcctgctgg gcatcccaca cacggaagac ggctgctacg tcttcactct tatggggaac actcggcttc acacccccat gtacttcttc ttcccttctg tgagctcccc caagatgctc tcctatgcgg gctgcgtgtc ccagctcttc ttcctgtaca cggtgatggc ctacgaccgc acggtaatca tgagccacag ggtgtgtgcc

120

180

240

300

360

420

Page 3552

069269_0225_SL.TXT

atcctggccg tggggacctc tttttttggc tgcattcagg ccaccttcct aaccactctc 480 accttccagt tgccctactg tggccccaat gaggtggatt acttcttctg tgatatcccg 540 gtgatgctga agctggcttg tgctgacacc tcagccctgg agagggtggg gttcgtcagc 600 gtgggcctca tgcccctcag ctgcttcctt ctcatcctca cctcctacag ccgcattgtc 660 tgctccatcc tgcagatccg ctctactgaa ggcagacgcc gtgccttctc cacctgcagt 720 gcccacctta ctgccatcct cctctccttt atgccagtgg tcctcatgta cctgcagccc 780 acccccaatc cctggctcaa tgcaactgtt caggtcctga ataacttggt cacccctatg 840 ctgaacccct tgatttacag cttgagaaat aaagaagtaa aatattctct gaggaaggta 900 ctacagcagg tagccttcct tcctgagca 929

<210> 3182 <211> 310 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (310)..(310) <223> Any amino acid <400> 3182

Met Gly Asn Ala Ser Val Val Thr Lys Phe Ile Leu Leu Gly Ile Pro 1 5 10 15 His Thr Glu Asp Leu Glu Thr Met Leu Phe Val Leu Phe Leu Gly Cys 20 25 30 Tyr Val Phe Thr Leu Met Gly Asn Leu Leu Ile Leu Leu Ala Ile Val 35 40 45 Ser Ser Thr Arg Leu His Thr Pro Met Tyr Phe Phe Leu Cys Gln Leu 50 55 60 Ser Val Cys Asp Ile Phe Phe Pro Ser Val Ser Ser Pro Lys Met Leu 65 70 75 80

Page 3553

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Phe Tyr Leu Ser Gly 85 Asn Ser Arg Ala Ile Ser Tyr Ala Gly Cys Val 90 95 Ser Gln Leu Phe Phe Tyr His Phe Leu Gly Cys Thr Glu Cys Phe Leu 100 105 110 Tyr Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Tyr Pro Leu 115 120 125 Arg Tyr Thr Val Ile Met Ser His Arg Val Cys Ala Ile Leu Ala Val 130 135 140 Gly Thr Ser Phe Phe Gly Cys Ile Gln Ala Thr Phe Leu Thr Thr Leu 145 150 155 160 Thr Phe Gln Leu Pro Tyr Cys Gly Pro Asn Glu Val Asp Tyr Phe Phe 165 170 175 Cys Asp Ile Pro Val Met Leu Lys Leu Ala Cys Ala Asp Thr Ser Ala 180 185 190 Leu Glu Arg Val Gly Phe Val Ser Val Gly Leu Met Pro Leu Ser Cys 195 200 205 Phe Leu Leu Ile Leu Thr Ser Tyr Ser Arg Ile Val Cys Ser Ile Leu 210 215 220 Gln Ile Arg Ser Thr Glu Gly Arg Arg Arg Ala Phe Ser Thr Cys Ser 225 230 235 240 Ala His Leu Thr Ala Ile Leu Leu Ser Phe Met Pro Val Val Leu Met 245 250 255 Tyr Leu Gln Pro Thr Pro Asn Pro Trp Leu Asn Ala Thr Val Gln Val 260 265 270 Leu Asn Asn Leu Val Thr Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu 275 280 285

Page 3554

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Arg Asn Lys Glu Val Lys Tyr Ser Leu Arg Lys Val Leu Gln Gln Val 290 295 300

Ala Phe Leu Pro Glu Xaa 305 310 <210> 3183 <211> 937 <212> DNA <213> Felis catus <400> 3183 atggatacag gaaaccattc ttcagtaact gagtttatcc ttgaggggtt aacagaccag 60 ccaggactcc agctccctct ctttttcctg tttctattga tctatatggt ctgcatggtg 120 ggaaattcgg gtttgatctt tttaattagg atcagttctc agcttcacac gcccatgtat 180 tattttctca gtaatttgtc cttcatagat ctctgctact ccactgtcat aattcccaag 240 atgttggtga actttgtatc agagaagaat ttcacctcct ttcctgagtg tatgacccag 300 ctcttttgct tctgcttctt tggtattgat gactcctaca tgctgacagc aatggcatat 360 gatcgttatg ttgccatctg taaccccttg ctctacaatg tcataatgtc cccaagaatc 420 tgttttctac tggccaccag tgtgtataca gtggggatca ttggagcctt ggtccacacc 480 agctacatat ctagtcgatc cttctgtgga atgaacatca tccaccatta cttctgtgac 540 atcctccctc ttctgaatat atcttgctca agagactaca ccaaggaact cttggtgatg 600 attttggttg gcgtcaatgt atttgcatgt gctgtagcca tcttcatctc ttatgccttc 660 attctttcca gtatcttatg catctgctca gctgaaggca ggtccaaagc tttcagtacc 720 tgcagctcac accttgcagc tgttggggtt ttctatggct ccatcatttt catgtatttt 780 aaaccatata ccagtgacat aatacaggag aaggtggcct ctgtgttcta taccacagtg 840 attcccatgc ttaatcccct tatctacagc cttaggaaca aggatgtcaa agaatccctt 900 aaaagagttc ttaatggtgg gtaactttct gggtctg 937 <210> 3184 <211> 307 <212> PRT <213> Felis catus

Page 3555

069269_0225_SL.TXT

<400> 3184 Asn His Ser Ser Val Thr Glu Phe Ile Leu Glu 15 Gly Met 1 Asp Thr Gly 5 10 Leu Thr Asp Gln Pro Gly Leu Gln Leu Pro Leu Phe Phe Leu Phe Leu 20 25 30 Leu Ile Tyr Met Val Cys Met Val Gly Asn Ser Gly Leu Ile Phe Leu 35 40 45 Ile Arg Ile Ser Ser Gln Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Thr Val Ile Ile Pro Lys 65 70 75 80 Met Leu Val Asn Phe Val Ser Glu Lys Asn Phe Thr Ser Phe Pro Glu 85 90 95 Cys Met Thr Gln Leu Phe Cys Phe Cys Phe Phe Gly Ile Asp Asp Ser 100 105 110 Tyr Met Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Ile Met Ser Pro Arg Ile Cys Phe Leu Leu 130 135 140 Ala Thr Ser Val Tyr Thr Val Gly Ile Ile Gly Ala Leu Val His Thr 145 150 155 160 Ser Tyr Ile Ser Ser Arg Ser Phe Cys Gly Met Asn Ile Ile His His 165 170 175 Tyr Phe Cys Asp Ile Leu Pro Leu Leu Asn Ile Ser Cys Ser Arg Asp 180 185 190 Tyr Thr Lys Glu Leu Leu Val Met Ile Leu Val Gly Val Asn Val Phe 195 200 205

Page 3556

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Ala Cys Ala Val Ala Ile Phe Ile Ser Tyr Ala Phe Ile Leu Ser Ser 210 215 220 Ile Leu Cys Ile Cys Ser Ala Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Ala Ala Val Gly Val Phe Tyr Gly Ser Ile Ile 245 250 255 Phe Met Tyr Phe Lys Pro Tyr Thr Ser Asp Ile Ile Gln Glu Lys Val 260 265 270 Ala Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu Ser Leu Lys Arg Val Leu 290 295 300 Asn Gly Gly

305

<210> 3185 <211> 916 <212> DNA <213> Felis catus <400> 3185 caaaaccttc ctcaatgctt tctttacatc cttgtttctc agactgtata ttaaagggtt 60 cagcatgggg atcactgtgg tgtaaaacac tgaggacacc ttctcctgtt ccagggagtt 120 actggaaggg ggcttgaaat acatgaatgt gattgacccc aaagaagatc cccacagcca 180 tgagatgaga gctgcaagtt ccaaaagctt tggaccggcc ccctgaggat tggatgtgaa 240 ggatgctatg gaagatgaag gcgtaggaaa tgaagacagc tagcgtgggc accaaggtgt 300 tcagtcccgc aatgataaaa agcagctgct cattgaggta tgtattggag caggagagat 360 tgaggagagg aaggacatca cagaagtaat ggctgatgat gtgggatctg cagaaagaca 420 gtttcatcat ggcacttgta tgggccatgg cagagagaaa gcccaggatg aaggcaacca 480 gcaccagcag tgagcaaacc ggagaggaca tggtcacact gtaaagcagg gggctacaga 540

Page 3557

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tagccacgta gcgatcatat gccatcacag tcaggaggta accctcagcc actacaaaaa 600 ctacgaagaa aaacagctgt gccatgcatt cagaataaag gatcatattc ttcttcccta 660 agaagttcac cagcattttg ggcgtaatga cagaggaata gcagagatcg atgaaggaca 720 agctgctgag gaagtagtac atgggggtgt gaagccaagg gcttactgta atcaggagaa 780 tcaagcccaa gttccccacc actgtcacta tatagattcc caggaacagg aggaagagag 840 gcagctggag ctctggccgc tgtgttaaac ccactaacac aaacttagtt gccgtggaat 900 gatttcctgc aaccat 916

<210> 3186 <211> 265 <212> PRT <213> Felis catus

<400> 3186 His Ser Thr Ala Thr Lys Phe Val Leu Val Gly Met 1 Val Ala Gly Asn 5 10 15 Leu Thr Gln Arg Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 Gly Ile Tyr Ile Val Thr Val Val Gly Asn Leu Gly Leu Ile Leu Leu 35 40 45 Ile Thr Val Ser Pro Trp Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Ser Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 Met Leu Val Asn Phe Leu Gly Lys Lys Asn Met Ile Leu Tyr Ser Glu 85 90 95 Cys Met Ala Gln Leu Phe Phe Phe Val Val Phe Val Val Ala Glu Gly 100 105 110 Tyr Leu Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125

Page 3558

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Pro Leu 130 Leu Tyr Ser Val Thr Met Ser Ser Pro Val Cys Ser Leu Leu 135 140 Val Leu Val Ala Phe Ile Leu Gly Phe Leu Ser Ala Met Ala His Thr 145 150 155 160 Ser Ala Met Met Lys Leu Ser Phe Cys Arg Ser His Ile Ile Ser His 165 170 175 Tyr Phe Cys Asp Val Leu Pro Leu Leu Asn Leu Ser Cys Ser Asn Thr 180 185 190 Tyr Leu Asn Glu Gln Leu Leu Phe Ile Ile Ala Gly Leu Asn Thr Leu 195 200 205 Val Pro Thr Leu Ala Val Phe Ile Ser Tyr Ala Phe Ile Phe His Ser 210 215 220 Ile Leu His Ile Gln Ser Ser Gly Gly Arg Ser Lys Ala Phe Gly Thr 225 230 235 240 Cys Ser Ser His Leu Met Ala Val Gly Ile Phe Phe Gly Val Asn His 245 250 255 Ile His Val Phe Gln Ala Pro Phe Gln 260 265

<210> 3187 <211> 925 <212> DNA <213> Felis catus <400> 3187 accttccccc aaccaccttt ctcagtgcgt ccttcacatc tttgttcctc aggctgtaga tcatgggatt cagcatgggg atcaccgtgg tgtaaaacac tgaggacacc ttcttctgtt ccatagtatt gctagaaggg ggtttgaaat acatgaatgt gatagatcca aaaaagatac ccacagccat gagatgagag ctacaggtgc caaaggcttt ggaccgtccc tcagcagagt

120

180

240

Page 3559

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gaatatggag gatgctcgaa aggatgaaag cgtaagagat gagtacagcc actgtaggta 300 ctaaggtatt aactcctcca ataataaaca gcagtatctc attgatatgg gtactggagc 360 aagagagagt caacaagggg agaatatcac aaaaataatg cctaacaaca tgagacccac 420 agaaggacaa tactgacatg tgggtagtat ggactgtagc cccaaacaaa cccagtgaat 480 ataccacagc catcattatg gagcagaccc tatgggacat gataatattg taaagcagtg 540 ggctacagat ggctacataa cggtcatatg ccatggcagt cagaaggtag ccttctgcaa 600 ttacaaaaac aaggaagaaa taaagctgag tcatgcatgc caaaaaggag ataatgttct 660 tctcagatat gaagttcacc agcatttttg gggtaatgac tgaggagtag cagagatcaa 720 tgaatgacag atgactgaga aaataataca ttggagagtg aagttgagaa ctgatagcaa 780 ttaagaggat catgcccagg ttccccacca ctgtgaccac gtatattcca aggaacagta 840 aaaagagtgg caactgaagc tctgggtgtt ttgctaaccc ttcaaggata aagtcagtca 900 tggaggaatg atttgaagta gccat 925

<210> 3188 <211> 309 <212> PRT <213> Felis catus <220>

<221> MOD_RES

<222> (309)..(309) Ser Ser Met Thr 10 Asp Phe Ile Leu Glu 15 Gly <223> Any amino <400> 3188 Met Ala Thr Ser 1 acid Asn His 5 Leu Ala Lys His 20 Pro Glu Leu Gln Leu 25 Pro Leu Phe Leu Leu 30 Phe Leu Gly Ile Tyr Val 35 Val Thr Val Val 40 Gly Asn Leu Gly Met 45 Ile Leu Leu Ile Ala Ile Ser 50 Ser Gln Leu 55 His Ser Pro Met Tyr 60 Tyr Phe Leu Ser

Page 3560

069269_0225_SL.TXT

His 65 Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys 70 75 80 Met Leu Val Asn Phe Ile Ser Glu Lys Asn Ile Ile Ser Phe Leu Ala 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Leu Val Phe Val Ile Ala Glu Gly 100 105 110 Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Leu Tyr Asn Ile Ile Met Ser His Arg Val Cys Ser Ile Met 130 135 140 Met Ala Val Val Tyr Ser Leu Gly Leu Phe Gly Ala Thr Val His Thr 145 150 155 160 Thr His Met Ser Val Leu Ser Phe Cys Gly Ser His Val Val Arg His 165 170 175 Tyr Phe Cys Asp Ile Leu Pro Leu Leu Thr Leu Ser Cys Ser Ser Thr 180 185 190 His Ile Asn Glu Ile Leu Leu Phe Ile Ile Gly Gly Val Asn Thr Leu 195 200 205 Val Pro Thr Val Ala Val Leu Ile Ser Tyr Ala Phe Ile Leu Ser Ser 210 215 220 Ile Leu His Ile His Ser Ala Glu Gly Arg Ser Lys Ala Phe Gly Thr 225 230 235 240 Cys Ser Ser His Leu Met Ala Val Gly Ile Phe Phe Gly Ser Ile Thr 245 250 255 Phe Met Tyr Phe Lys Pro Pro Ser Ser Asn Thr Met Glu Gln Lys Lys 260 265 270

Page 3561

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Val Ser Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Asp Ala Leu Arg Lys Val 290 295 300 Val Gly Gly Arg Xaa

305 <210> 3189 <211> 936 <212> DNA <213> Felis catus <400> 3189

tcaagaaaat gtttttctat tcaagctttc tttcagggca accttaacct ccttgttcct 60 gaagctatag atcagaggat tgagcatagg caccacaata gtatagaaca cagtggacac 120 tttcccctgg tccatggaca aaacagaaga aggatgaaga tacatgaatg cccccgaccc 180 aaagaaaaca gaaacaacaa ttatatgtga gctacaagtg ctaaaagctt tggaccttcc 240 ttcaggggaa tgcatgcgaa ggatgctggt gaggatcaaa gagtaagaga taatgatagt 300 gaggctgggc acacccacat caaagcccac aacaatgaga actaccagtt cattgatgtg 360 agtgtttgtg caggagagct ccagaagggg gaggatgtca cacatgtagt ggttgatggt 420 gttggcgtca cagaaggtca acctgagcat gcatcctgtg tgggcccagg caccaataaa 480 cgcccccaca tatacaatca cagccagcag agaacagacc tgaggggaca tggtgaccgt 540 gtataacaag ggcttgcaaa tggccacata gcgatcatag gccattactg tcaacacata 600 acactctgca ctgacaaaga aacagtagaa aaagagctga gtcatgcatc ctgcatagga 660 gatggtgttc agctttgaca caaagtttac cagcagtttt ggggtaatga cagaagagta 720 acacaggtca ataaaggata aattaaagag gaaatagtac atgggggtgt gaaggtgaga 780 attcagtcca attagagtga ccaagcccag gtttcctgcc acagtgacaa tgtagattcc 840 taggaaaaga aagaacagag gcagctggat ctctgaatat ttggttaaac ccacaaggaa 900 aaactcagtg actaaggaac tgtttcccat atccat 936

Page 3562

069269_0225_SL.TXT <210> 3190 <211> 311 <212> PRT <213> Felis catus

<400> 3190 Phe Leu Val 15 Gly Met 1 Asp Met Gly Asn Ser Ser Leu 5 Val Thr 10 Glu Phe Leu Thr Lys Tyr Ser Glu Ile Gln Leu Pro Leu Phe Phe Leu Phe Leu 20 25 30 Gly Ile Tyr Ile Val Thr Val Ala Gly Asn Leu Gly Leu Val Thr Leu 35 40 45 Ile Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Tyr Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80 Leu Leu Val Asn Phe Val Ser Lys Leu Asn Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Met Thr Gln Leu Phe Phe Tyr Cys Phe Phe Val Ser Ala Glu Cys 100 105 110 Tyr Val Leu Thr Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Thr Val Thr Met Ser Pro Gln Val Cys Ser Leu Leu 130 135 140 Ala Val Ile Val Tyr Val Gly Ala Phe Ile Gly Ala Trp Ala His Thr 145 150 155 160 Gly Cys Met Leu Arg Leu Thr Phe Cys Asp Ala Asn Thr Ile Asn His 165 170 175 Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Leu Ser Cys Thr Asn Thr 180 185 190

Page 3563

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His Ile Asn Glu Leu Val Val Leu Ile Val Val Gly Phe Asp Val Gly 195 200 205 Val Pro Ser Leu Thr Ile Ile Ile Ser Tyr Ser Leu Ile Leu Thr Ser 210 215 220 Ile Leu Arg Met His Ser Pro Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ile Val Val Ser Val Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu His Pro Ser Ser Val Leu Ser Met Asp Gln Gly Lys 260 265 270 Val Ser Thr Val Phe Tyr Thr Ile Val Val Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Phe Arg Asn Lys Glu Val Lys Val Ala Leu Lys Glu Ser 290 295 300 Leu Asn Arg Lys Thr Phe Ser

305 310 <210> 3191 <211> 930 <212> DNA <213> Felis catus <400> 3191

tcaaaacctt ctacttagag tttttctcaa agcaagttta acatctttgt ttctcaagct 60 gtaaagtaaa gggttcatca tgggaactgt attggtgtaa aagatagatg atatttttcc 120 ctcatccata gacccagcag aagatggttt aagatacata aatgcacctg atccaaagaa 180 caaggaaaca gaaattatgt gggaactgca ggtgctgaac gctttggacc tgccctcagt 240 ggaaccgatg tggaggatgc tggaaaggat gcaaccataa gagacaaaga tggtgacact 300 gggcacaatg atgttgatgc ccaccacgat gaaaaccacc agctcattca cgtaggtgct 360

Page 3564

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tgtgcaggag agctggagaa gggggaggat gtcacacaaa taatggttga tggtgtttgc 420 atcacagaag gtcagtccca gcatgcttcc tgtgtgagcc acagcacctg aaaatgccat 480 caaatatgaa ccaagcataa ggctggaaca cgctttaggg gacatgacaa cattatacaa 540 aagtgggtta cagatggcca catagcgatc ataggccatt gatgtcaaca catagcattc 600 agaaatagca aaaaaacaga aaaagtaaag ctgggtcatg caccccctgt aggagataat 660 atttttcttt gatacaaagt tagtcagcat tttgggtgta aacacagaag aataacagaa 720 atctatgaag gacaaattga agagaaaaaa gtacattgga gtatgtaggt gtgaattcag 780 cccaattaga gttatcaagc ccaaatttcc caacacagtg accacataca tgactagaaa 840 cagacagaac agggggagct ggagatctgg taggtctgtt agccccacca gaatgaatgc 900 agccacaaaa gaactgtttc caggagccat 930

<210> 3192 <211> 309 <212> PRT <213> Felis catus <400> 3192

Met Ala Pro Gly Asn Ser Ser Phe Val Ala Ala Phe Ile Leu Val Gly 1 5 10 15 Leu Thr Asp Leu Pro Asp Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu 20 25 30 Val Met Tyr Val Val Thr Val Leu Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Ile Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Phe Thr Pro Lys 65 70 75 80 Met Leu Thr Asn Phe Val Ser Lys Lys Asn Ile Ile Ser Tyr Arg Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Cys Phe Phe Ala Ile Ser Glu Cys Page 356 5

100

069269_0225_SL.TXT 105 110

Tyr Val Leu 115 Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 120 125 Pro Leu Leu Tyr Asn Val Val Met Ser Pro Lys Ala Cys Ser Ser Leu 130 135 140 Met Leu Gly Ser Tyr Leu Met Ala Phe Ser Gly Ala Val Ala His Thr 145 150 155 160 Gly Ser Met Leu Gly Leu Thr Phe Cys Asp Ala Asn Thr Ile Asn His 165 170 175 Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr 180 185 190 Tyr Val Asn Glu Leu Val Val Phe Ile Val Val Gly Ile Asn Ile Ile 195 200 205 Val Pro Ser Val Thr Ile Phe Val Ser Tyr Gly Cys Ile Leu Ser Ser 210 215 220 Ile Leu His Ile Gly Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ile Ser Val Ser Leu Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu Lys Pro Ser Ser Ala Gly Ser Met Asp Glu Gly Lys 260 265 270 Ile Ser Ser Ile Phe Tyr Thr Asn Thr Val Pro Met Met Asn Pro Leu 275 280 285 Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys Leu Ala Leu Arg Lys Thr 290 295 300 Leu Ser Arg Arg Phe

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069269_0225_SL.TXT

305 <210> 3193 <211> 927 <212> DNA <213> Felis catus <400> 3193

tcaaaacttt cccctattca gagtttttct cagagcaagt ttaatgtctt tgtttctcaa 60 gctgtaaatg aatgggttca tcaagggaac tatactggta taaaagacag aagagatttt 120 cccctcatcc atagacccag cagaagatgg tttaagatac ataaatgcac ctgatccaaa 180 gaacaaggaa acagcaatta tgtgggaact gcaggtgctg aacgctttgg acctgccctc 240 agtggagctg atgcggagga tgctggagag gatgcaacca taagacacaa agatggtgac 300 actgggcaca atcacattga ttcccaccac gatgaaaacc accagttcat ttacataggt 360 gcttgtgcag gagagctgga gaagggggag gatgtcacac aaataatggt tgatggtgtt 420 tgcatcgcag aaggtcagtc tcagcatgca tcctgtgtgg gccatagcac ccgaaaatgc 480 catcaaatat gaaccaagca taaggctgga acacgcttta ggggacagga aaacattata 540 caaaagtggg ttacagatgg ccacatagcg atcataggcc attgatgtga gcacatagca 600 ttcagaaata ccaaaaaaac tgaaaaggta aagctgggcc atgcaccccc tataggagat 660 gatattcttc tttgatgtga agttaaatag cattttgggt gtaaacacag aagaataaca 720 gaagtcgatg aaggacaaat tggagaggaa aaagtacatg ggggtgtgta gatgtgaatt 780 cagcccaatt agagttatca agcccaaatt tcccgatgca gtgaccacgt aaatgactag 840 aaacaggcag aacaggggga gctggagatc tggtaggtct gttagcccca gcagaatgaa 900 ttcagtcaca aaagaagcat tcccagg 927

<210> 3194 <211> 308 <212> PRT <213> Felis catus <400> 3194

Pro Gly Asn Ala Ser Phe Val Thr Glu Phe Ile Leu Leu Gly Leu Thr 1 5 10 15

Page 3567

069269_0225_SL.TXT

Asp Leu Pro Asp Leu Gln 20 Leu Pro Leu Phe 25 Cys Leu Phe Leu Val Ile 30 Tyr Val Val Thr Ala Ser Gly Asn Leu Gly Leu Ile Thr Leu Ile Gly 35 40 45 Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Phe Ile Asp Phe Cys Tyr Ser Ser Val Phe Thr Pro Lys Met Leu 65 70 75 80 Phe Asn Phe Thr Ser Lys Lys Asn Ile Ile Ser Tyr Arg Gly Cys Met 85 90 95 Ala Gln Leu Tyr Leu Phe Ser Phe Phe Gly Ile Ser Glu Cys Tyr Val 100 105 110 Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu 115 120 125 Leu Tyr Asn Val Phe Leu Ser Pro Lys Ala Cys Ser Ser Leu Met Leu 130 135 140 Gly Ser Tyr Leu Met Ala Phe Ser Gly Ala Met Ala His Thr Gly Cys 145 150 155 160 Met Leu Arg Leu Thr Phe Cys Asp Ala Asn Thr Ile Asn His Tyr Leu 165 170 175 Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr Tyr Val 180 185 190 Asn Glu Leu Val Val Phe Ile Val Val Gly Ile Asn Val Ile Val Pro 195 200 205 Ser Val Thr Ile Phe Val Ser Tyr Gly Cys Ile Leu Ser Ser Ile Leu 210 215 220

Page 3568

069269_0225_SL.TXT

Arg Ile 225 Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys Ser 230 235 240 Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala Phe Met 245 250 255 Tyr Leu Lys Pro Ser Ser Ala Gly Ser Met Asp Glu Gly Lys Ile Ser 260 265 270 Ser Val Phe Tyr Thr Ser Ile Val Pro Leu Met Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Ile Lys Leu Ala Leu Arg Lys Thr Leu Asn 290 295 300 Arg Gly Lys Phe

305 <210> 3195 <211> 933 <212> DNA <213> Felis catus <400> 3195

tcaaaacctt ctcctactga aggtttttct cagagcagtt ttaacatctt tgtttctcaa 60 gctgtagagt aaagggttca tcatgggaac cacactggta taaaagacag aagagatttt 120 ccccttatgc atagacagag cagacgacgg tttgagatat gtaaatgcac ctgatccaaa 180 gaacaaggaa acagcaatta tgtgggaact gcaggtgctg aacgctttgg acctgccctc 240 agtggagctg atgcggagga tgctggaaag gatgcaaccg taagacacaa agatggtgac 300 actgggcaca atgatgttga tgcccaccac gatgaaaacc accagctcat tcacgtaggt 360 gcttgtgcag gagagctgga gaagggggag gatgtcacac aaataatggt tgatggtgtt 420 tgcatcgcag aaggtcagtc tcagcatgca tcctgtgtgg gccatagcac ccgaaaatgc 480 catcaaatat gaaccaagca taaggctgga acacacttta ggggacagga caacattata 540 caaaagtggg ttacagatgg ccacatagcg atcataggcc attgatgtga gcacatagca 600 ttcagaaatg ataaaaaaac aaaaaaagta gaattgggtc atgcaccccc tataggagat 660

Page 3569

069269_0225_SL.TXT aatattcttc tttgatgtga aattaatcag cattttgggt gtaaacacag aagcataaca gaggtctatg aaggacaaat tggagaggaa aaagtacatg gggatatgta ggtgtgaatt cagcccaatt agagttatca agcccaaatt tcctaacaca gtgaccacat acatgactag aaacaggcag aacaggggga gctggagatc tggtaggtct gttagcccta ccagcataaa ttcagtcaca aaagaggcat ttgtaggagc cat

720

780

840

900

933 <210> 3196 <211> 310 <212> PRT <213> Felis catus <400> 3196

Met Ala Pro Thr 1 Asn 5 Ala Ser Phe Val Thr Glu Phe Met 10 Leu Val 15 Gly Leu Thr Asp Leu Pro Asp Leu Gln Leu Pro Leu Phe Cys Leu Phe Leu 20 25 30 Val Met Tyr Val Val Thr Val Leu Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Ile Gly Leu Asn Ser His Leu His Ile Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ala Ser Val Phe Thr Pro Lys 65 70 75 80 Met Leu Ile Asn Phe Thr Ser Lys Lys Asn Ile Ile Ser Tyr Arg Gly 85 90 95 Cys Met Thr Gln Phe Tyr Phe Phe Cys Phe Phe Ile Ile Ser Glu Cys 100 105 110 Tyr Val Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Asn Val Val Leu Ser Pro Lys Val Cys Ser Ser Leu 130 135 140

Page 3570

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Met 145 Leu Gly Ser Tyr Leu Met Ala Phe Ser Gly Ala Met Ala His Thr 150 155 160 Gly Cys Met Leu Arg Leu Thr Phe Cys Asp Ala Asn Thr Ile Asn His 165 170 175 Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr 180 185 190 Tyr Val Asn Glu Leu Val Val Phe Ile Val Val Gly Ile Asn Ile Ile 195 200 205 Val Pro Ser Val Thr Ile Phe Val Ser Tyr Gly Cys Ile Leu Ser Ser 210 215 220 Ile Leu Arg Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala 245 250 255 Phe Thr Tyr Leu Lys Pro Ser Ser Ala Leu Ser Met His Lys Gly Lys 260 265 270 Ile Ser Ser Val Phe Tyr Thr Ser Val Val Pro Met Met Asn Pro Leu 275 280 285 Leu Tyr Ser Leu Arg Asn Lys Asp Val Lys Thr Ala Leu Arg Lys Thr 290 295 300 Phe Ser Arg Arg Arg Phe

305 310 <210> 3197 <211> 933 <212> DNA <213> Felis catus <400> 3197 tcaaaacact ctcctaccga gggttcttct cagagcaatt ttaacatctt tgttcctcaa

Page 3571

069269_0225_SL.TXT

actatagatt aaggggttca tcatgggaac cacattggta taaaagacag aagagatttt 120 accctcatcc atagacccaa cagaagatgg tttaagatac ataattgcac ctgacccaaa 180 gaacaaggaa acagcaatta tgtgggaact gcaggtgctg aacgctttgg acctgccctc 240 agtggaactg atgcggagga tgctggagag gatgcaacca taagacacaa agatggtgac 300 actgggcaca atgatgttga tgcccaccac gatgaaaacc accagctcat tcacgtaggt 360 gcttgtgcag gaaagctgga gcacagggag gatgtcacac aaataatggt tgatggtgtt 420 tgcatcacag aaggtcagtc tcagcatgca tcctgtgtgg gccatagcac ccgaaaatgc 480 catcaaatat gaaccaagca taaggctgga acacgcttta ggggacatga caacattata 540 caaaagtggg ttacagatgg ccacatagcg atcataggcc attgatgtca gcacatagca 600 ttcagaaatt acaaaaaaac agaaaaagta aagctgggtc atgcatccca tataagagat 660 aatgtttttc tttgatagga aattcatcag catttttggt gtcaatactg aagaatagaa 720 gaggtctatg aaggacaaat tgaagaggaa aaagtacatg ggggtgtgta ggtattaatt 780 cagcccaatt aaaatgatca agcccatatt tcccaacaca gtgaccacat acatgactag 840 aaataggcag aacaggggaa gctggagttc tgataggtct gttaatccca ccagaatgaa 900 ttcagtcaca gaagaggcat ttccaggagt cat 933

<210> 3198 <211> 252 <212> PRT <213> Felis catus <400> 3198

Met Tyr Phe Phe Leu Phe Asn Leu Ser Phe Ile Asp Leu Phe Tyr Ser 1 5 10 15 Ser Val Leu Thr Pro Lys Met Leu Met Asn Phe Leu Ser Lys Lys Asn 20 25 30 Ile Ile Ser Tyr Met Gly Cys Met Thr Gln Leu Tyr Phe Phe Cys Phe 35 40 45 Phe Val Ile Ser Glu Cys Tyr Val Leu Thr Ser Met Ala Tyr Asp Arg

50 55 60

Page 3572

069269_0225_SL.TXT

Tyr 65 Val Ala Ile Cys Asn 70 Pro Leu Leu Tyr Asn Val Val Met Ser Pro 75 80 Lys Ala Cys Ser Ser Leu Met Leu Gly Ser Tyr Leu Met Ala Phe Ser 85 90 95 Gly Ala Met Ala His Thr Gly Cys Met Leu Arg Leu Thr Phe Cys Asp 100 105 110 Ala Asn Thr Ile Asn His Tyr Leu Cys Asp Ile Leu Pro Val Leu Gln 115 120 125 Leu Ser Cys Thr Ser Thr Tyr Val Asn Glu Leu Val Val Phe Ile Val 130 135 140 Val Gly Ile Asn Ile Ile Val Pro Ser Val Thr Ile Phe Val Ser Tyr 145 150 155 160 Gly Cys Ile Leu Ser Ser Ile Leu Arg Ile Ser Ser Thr Glu Gly Arg 165 170 175 Ser Lys Ala Phe Ser Thr Cys Ser Ser His Ile Ile Ala Val Ser Leu 180 185 190 Phe Phe Gly Ser Gly Ala Ile Met Tyr Leu Lys Pro Ser Ser Val Gly 195 200 205 Ser Met Asp Glu Gly Lys Ile Ser Ser Val Phe Tyr Thr Asn Val Val 210 215 220 Pro Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 225 230 235 240 Ile Ala Leu Arg Arg Thr Leu Gly Arg Arg Val Phe

245 250 <210> 3199 <211> 928

Page 3573

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 3199 tttgtaattc tcttcagggt tttcttcaga gcaagtttga tatctttatt cctgaggcta 60 taaatgaaag ggttgagcat gggtaccaca ttggtgtaaa acactgagaa aaatttcctt 120 ggcttacaga cccagaagat gatggcttga catgagtgag caacccaaat ccatagaaca 180 ggccaacagt tactatgtgg gagccacagg tgctgaaggc tttgggccaa ccctgagctg 240 atgagatgtg aaggatattg aaaagaatca aaaaataaga aataaagata ataaggctag 300 atgcaatgac aactgagccc acaataacag agataaccag ctcactggca taggtactgc 360 tgcaggagag ctggaggagg gggaaaatgt cacacatgta atggtcaatg gcactggagt 420 cacaaaagat cagcctgatc atgcaccctg tgtggaccat ggcaccagca aaacccatca 480 catatgaacc agacatcagc agagaacaga ctagagggga catggtaatg gtgtatagca 540 gaggtttaca gatggccaca tagcgatcat aggccatggc tgtcaacaca tagcattcag 600 agttgacaaa aaagcagaag aaaaataact gagtcatgca tcccattaag gagatgatgt 660 tcttgtctga aataaagctc atcagcattt ttggggtaga gacaaatgaa taacaaagat 720 caatcaggga cagattgaag aggaaaaaat acatgggggt gtgaaggtgt gaattcaggc 780 aaattaaatt aattaagctc aaattgccca ccacagtgac cacatagttc accaaaaaca 840 gaaaaaacag aggtagttgg agttcaggtt ggtctgttaa tcccataagg ataaagtcag 900 tcacagagga gtcattttcc acagccat 928 <210> 3200 <211> 300 <212> PRT <213> Felis catus

<400> 3200 Met 1 Ala Val Glu Asn Asp Ser Ser Val Thr Asp Phe Ile Leu Met 15 Gly 5 10 Leu Thr Asp Gln Pro Glu Leu Gln Leu Pro Leu Phe Phe Leu Phe Leu 20 25 30 Val Asn Tyr Val Val Thr Val Val Gly Asn Leu Ser Leu Ile Asn Leu

Page 3574

069269_0225_SL.TXT 40 45

Ile Cys Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60 Asn Leu Ser Leu Ile Asp Leu Cys Tyr Ser Phe Val Ser Thr Pro Lys 65 70 75 80 Met Leu Met Ser Phe Ile Ser Asp Lys Asn Ile Ile Ser Leu Met Gly 85 90 95 Cys Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Asn Ser Glu Cys 100 105 110 Tyr Val Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Thr Ile Thr Met Ser Pro Leu Val Cys Ser Leu Leu 130 135 140 Met Ser Gly Ser Tyr Val Met Gly Phe Ala Gly Ala Met Val His Thr 145 150 155 160 Gly Cys Met Ile Arg Leu Ile Phe Cys Asp Ser Ser Ala Ile Asp His 165 170 175 Tyr Met Cys Asp Ile Phe Pro Leu Leu Gln Leu Ser Cys Ser Ser Thr 180 185 190 Tyr Ala Ser Glu Leu Val Ile Ser Val Ile Val Gly Ser Val Val Ile 195 200 205 Ala Ser Ser Leu Ile Ile Phe Ile Ser Tyr Phe Leu Ile Leu Phe Asn 210 215 220 Ile Leu His Ile Ser Ser Ala Gln Gly Trp Pro Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Ile Val Thr Val Gly Leu Phe Tyr Gly Phe Gly Leu

Page 3575

245

255

069269_0225_SL.TXT

250

Leu Thr His Val Lys Pro Ser Ser Ser Gly Ser Val Ser Gln Gly Asn 260 265 270 Phe Ser Gln Cys Phe Thr Pro Met Trp Tyr Pro Cys Ser Thr Leu Ser 275 280 285 Phe Ile Ala Ser Gly Ile Lys Ile Ser Asn Leu Leu 290 295 300

<210> 3201 <211> 986 <212> DNA <213> Felis catus <400> 3201

attttaatca agactttcct cagtgcaatt ttgacatcct tattcctcaa actgtagatc 60 aggggattga gcatgggccc cacattagtg tagaaaactg aagaaacttt cccctgctcc 120 atagaccccg gagaagaata tttaagatac atgaatgctg ctgagccaaa gaaaagagaa 180 atagcaatga tgtgagaact acaggtactg aaggcttttg atcgtccttg agcagatctg 240 atatgaagaa tgctagtgag gataaagacg taagaaatca ggatggtaaa actgggtact 300 gtgatattaa ttcccacgac tatcagaact actacctcgt tgacataggt gctgctgcaa 360 gacagttgga ggagaggaag aatatcacac aggtaatggt tgatgacatt aacactgcag 420 aaggttagtc tgagcatgca ccctgtgtgg gcagaggctc cagcaaaccc catcatatat 480 gcagcaacag tcagcaaggc acagacctgg tgggacatgg ttaccttata cagcaacgga 540 ttacagatgg ccacgtagcg atcgtaggcc attgaggtca acatatagca ttccgagatg 600 acaaaaaaga gaaagaaaaa cagctgagtc atgcagccaa cataggagat gatattctcc 660 cttgatacaa agttcatcag catcttgggg gtgaaagcag aagagtaaca gacatcaatg 720 aaggataggt tgaagaggaa gtagtacatg ggggtatgga ggtgagaatt cagacgaata 780 agagtgacca agccaacgtt gcccaccatg gtgacaatgt agatcaccag aaacaggaag 840 aagaggggtt gctggagctc tggacggtct gttaggccag caagaagaaa ttcagtcact 900 aaggactcat ttctaaccag tattcttctc ttcagaaatc tgtgagaaca gaagaaaatc 960

Page 3576

069269_0225_SL.TXT ccattagaga ccccagctct ctcctt

986 <210> 3202 <211> 329 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (329)..(329) <223> Any amino acid

<400> 3202 Ala Gly 5 Val Ser Asn Gly Ile Phe Phe Cys Ser His Arg Lys 1 Glu Arg 10 15 Phe Leu Lys Arg Arg Ile Leu Val Arg Asn Glu Ser Leu Val Thr Glu 20 25 30 Phe Leu Leu Ala Gly Leu Thr Asp Arg Pro Glu Leu Gln Gln Pro Leu 35 40 45 Phe Phe Leu Phe Leu Val Ile Tyr Ile Val Thr Met Val Gly Asn Val 50 55 60 Gly Leu Val Thr Leu Ile Arg Leu Asn Ser His Leu His Thr Pro Met 65 70 75 80 Tyr Tyr Phe Leu Phe Asn Leu Ser Phe Ile Asp Val Cys Tyr Ser Ser 85 90 95 Ala Phe Thr Pro Lys Met Leu Met Asn Phe Val Ser Arg Glu Asn Ile 100 105 110 Ile Ser Tyr Val Gly Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe 115 120 125 Val Ile Ser Glu Cys Tyr Met Leu Thr Ser Met Ala Tyr Asp Arg Tyr 130 135 140

Page 3577

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Val 145 Ala Ile Cys Asn Pro 150 Leu Leu Tyr Lys Val Thr Met Ser His Gln 155 160 Val Cys Ala Leu Leu Thr Val Ala Ala Tyr Met Met Gly Phe Ala Gly 165 170 175 Ala Ser Ala His Thr Gly Cys Met Leu Arg Leu Thr Phe Cys Ser Val 180 185 190 Asn Val Ile Asn His Tyr Leu Cys Asp Ile Leu Pro Leu Leu Gln Leu 195 200 205 Ser Cys Ser Ser Thr Tyr Val Asn Glu Val Val Val Leu Ile Val Val 210 215 220 Gly Ile Asn Ile Thr Val Pro Ser Phe Thr Ile Leu Ile Ser Tyr Val 225 230 235 240 Phe Ile Leu Thr Ser Ile Leu His Ile Arg Ser Ala Gln Gly Arg Ser 245 250 255 Lys Ala Phe Ser Thr Cys Ser Ser His Ile Ile Ala Ile Ser Leu Phe 260 265 270 Phe Gly Ser Ala Ala Phe Met Tyr Leu Lys Tyr Ser Ser Pro Gly Ser 275 280 285 Met Glu Gln Gly Lys Val Ser Ser Val Phe Tyr Thr Asn Val Gly Pro 290 295 300 Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Ile 305 310 315 320 Ala Leu Arg Lys Val Leu Ile Lys Xaa

<210> 3203 <211> 933 <212> DNA <213> Felis catus

325

Page 3578

069269_0225_SL.TXT <400> 3203 atggctatgg aaaatgactc ttcagtgaca gagttcatcc tggtaggatt tacagaccga 60 cctcagctcc agttacccct tttctttctc tttttactga actatgtggt cactatggta 120 ggaaatttga gcctagttaa tctaatatgc ctgaattctc acctgcacac tcccatgtac 180 tttttcatct tcaacttatc cttcatagat ttctgccact ctttggtcat tacccctaaa 240 atgctgatga gctttgtctc agagaagaac atcatttcct ttacagaatg catgactcag 300 ctgtttttct tctgtttctt tgtgcattct gagtgctatg tgttgacagc catggcctat 360 gatcgctatg tggccatctg taaacctctg gtgtacacgg tcaccatgtc ccctcaggtc 420 tgttctctgc tgatgtttgg ttcttacgtg atggggtttg ctggtgccat gatccacata 480 ggggacatgg tcagattgtc cttttgtgat tctaacatca tcaaccatta catgtgtgac 540 atcttccccc tccttcagct ctcctgcagt ggcacctatg ccagtgagtt gctgaattcc 600 attattgtga gcacagttgt cataatatcc ggcttcatta ttttcatttc ttatgctttg 660 gtcctgtcca atgtcctcca cgtctcatca gctcagggtt ggcccaaagc cttcagcacc 720 tgtggctccc acatagtaac tgtgggtctg ttctatgggt ctgggttgtt cacacatctc 780 aagacctctc cttctgattc tgtggaccag gggaaattct tttcagtatt ttacaccaat 840 gtaataccca tgttgaaccc cctcatctat agtctaagga acaaggatgt caaatgtgct 900 ctgaaaaaaa ccctgaagag aattgcaaac taa 933 <210> 3204 <211> 310 <212> PRT <213> Felis catus <400> 3204

Met 1 Ala Met Glu Asn Asp Ser Ser Val Thr Glu Phe Ile Leu Val Gly 5 10 15 Phe Thr Asp Arg Pro Gln Leu Gln Leu Pro Leu Phe Phe Leu Phe Leu 20 25 30 Leu Asn Tyr Val Val Thr Met Val Gly Asn Leu Ser Leu Val Asn Leu 35 40 45

Page 3579

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Ile Cys Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Ile Phe 50 55 60 Asn Leu Ser Phe Ile Asp Phe Cys His Ser Leu Val Ile Thr Pro Lys 65 70 75 80 Met Leu Met Ser Phe Val Ser Glu Lys Asn Ile Ile Ser Phe Thr Glu 85 90 95 Cys Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val His Ser Glu Cys 100 105 110 Tyr Val Leu Thr Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Val Tyr Thr Val Thr Met Ser Pro Gln Val Cys Ser Leu Leu 130 135 140 Met Phe Gly Ser Tyr Val Met Gly Phe Ala Gly Ala Met Ile His Ile 145 150 155 160 Gly Asp Met Val Arg Leu Ser Phe Cys Asp Ser Asn Ile Ile Asn His 165 170 175 Tyr Met Cys Asp Ile Phe Pro Leu Leu Gln Leu Ser Cys Ser Gly Thr 180 185 190 Tyr Ala Ser Glu Leu Leu Asn Ser Ile Ile Val Ser Thr Val Val Ile 195 200 205 Ile Ser Gly Phe Ile Ile Phe Ile Ser Tyr Ala Leu Val Leu Ser Asn 210 215 220 Val Leu His Val Ser Ser Ala Gln Gly Trp Pro Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Ile Val Thr Val Gly Leu Phe Tyr Gly Ser Gly Leu 245 250 255

Page 3580

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Phe Thr His Leu Lys Thr Ser Pro Ser Asp Ser Val Asp Gln Gly Lys 260 265 270 Phe Phe Ser Val Phe Tyr Thr Asn Val Ile Pro Met Leu Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Cys Ala Leu Lys Lys Thr 290 295 300 Leu Lys Arg Ile Ala Asn

305 310 <210> 3205 <211> 930 <212> DNA <213> Felis catus <400> 3205

tcaggagagc actgttctca gggttttacc cagagcaagt ttcacatcct tattcctcaa 60 actgtagatc aaaggattaa gcatgggaac cacattggtg taaaagactg aggcaaattt 120 actctggtcc atagatgcag gaaaagagct tgttaaatag gtgaatgccc ctgacccaaa 180 aaacaaagca acagcaatta tgtgggagcc acatgtgctg atggctttgg atctaccctc 240 agcagaagga atatggagga tattagagag aatcaaggca taagaaatga aaatgctaat 300 actggatatt gtgatgacca ctcccacaac aataaaaaac actagctcat tgacatgggt 360 gctggtgcag gagagctgca ggagaggaag aacttcacac agataatggt ggatgatgtt 420 ggaattacag aaagtcagtc tccatatgct cccagtgtgg gccatggctc cagcaaaccc 480 tatcacatat gaaccaaaca tgagcagaga acagacctga ggggacatgg tgaccgtgta 540 cagcagaggc ttgcagatag ccacatagcg atcataggcc attgatacca acacatagca 600 ctcagaattg acaaagaaac agaagaaaaa aagttgagtc acgcatccca cgtaagagat 660 gacattttct gacagaaaat cattcagcat tttgggggta aatacagagg aataacagag 720 atctataaaa gacaagttga agagaaaaaa gtacatggga gtgtgaaggc tagaatttag 780 cccaattaag gtaatcaagc ccaagttgcc caccacagta aacacataga tccctaagaa 840 caggatgaag aggggaagct ggagctctgg ttgttctgat aatcccacta ggataaactc 900

Page 3581

069269_0225_SL.TXT agtcactgag gagctgtttc tcagagtcat

930 <210> 3206 <211> 309 <212> PRT <213> Felis catus <400> 3206

Met 1 Thr Leu Arg Asn 5 Ser Ser Ser Val Thr Glu Phe Ile Leu Val Gly 10 15 Leu Ser Glu Gln Pro Glu Leu Gln Leu Pro Leu Phe Ile Leu Phe Leu 20 25 30 Gly Ile Tyr Val Phe Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Ile Gly Leu Asn Ser Ser Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Leu Cys Tyr Ser Ser Val Phe Thr Pro Lys 65 70 75 80 Met Leu Asn Asp Phe Leu Ser Glu Asn Val Ile Ser Tyr Val Gly Cys 85 90 95 Val Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Asn Ser Glu Cys Tyr 100 105 110 Val Leu Val Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro 115 120 125 Leu Leu Tyr Thr Val Thr Met Ser Pro Gln Val Cys Ser Leu Leu Met 130 135 140 Phe Gly Ser Tyr Val Ile Gly Phe Ala Gly Ala Met Ala His Thr Gly 145 150 155 160 Ser Ile Trp Arg Leu Thr Phe Cys Asn Ser Asn Ile Ile His His Tyr 165 170 175

Page 3582

069269_0225_SL.TXT

Leu Cys Glu Val Leu Pro Leu Leu Gln Leu Ser Cys Thr Ser Thr His 180 185 190 Val Asn Glu Leu Val Phe Phe Ile Val Val Gly Val Val Ile Thr Ile 195 200 205 Ser Ser Ile Ser Ile Phe Ile Ser Tyr Ala Leu Ile Leu Ser Asn Ile 210 215 220 Leu His Ile Pro Ser Ala Glu Gly Arg Ser Lys Ala Ile Ser Thr Cys 225 230 235 240 Gly Ser His Ile Ile Ala Val Ala Leu Phe Phe Gly Ser Gly Ala Phe 245 250 255 Thr Tyr Leu Thr Ser Ser Phe Pro Ala Ser Met Asp Gln Ser Lys Phe 260 265 270 Ala Ser Val Phe Tyr Thr Asn Val Val Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Leu Ala Leu Gly Lys Thr Leu 290 295 300 Arg Thr Val Leu Ser

305 <210> 3207 <211> 945 <212> DNA <213> Felis catus <400> 3207 tcaagagaat gtctttttgc tcaatgattt cttcagagca actttgacat ctttatttct taagctatag attagcgggt tgagcatggg cacaacggtg gtatagaaca aggaggacac tttcccctga ttcataggta aaagagagga tggtttgagg tacataaatg cccctgaccc aaagaaaaga gaaacagcaa ttatgtgaga gctgcatgtg ctgaaggctt tggacctgcc

120

180

240

Page 3583

069269_0225_SL.TXT ctcagtggaa aactgtgggc ggtgctggtg attgttggca ccccatcaca gtacaccagt ggactcagag gatggtgttc aaaatctatg cagcccaatc aaacaggaag ttctgtcaca cgaatatgga acgccaatat caagagcgct cagaaggtca tagacaccca gggttacaga acaacaaaga tttgagacaa aaggacaagt agggttatca aagaggggca gaggagttct gaatgctggt caatgcccac caagaagggg gcctcaccat acagaagaag tggcggtgta aaagaaaaaa aactcatcag tgaagaggaa gacccaggtt tccgaagtcc cagctgccat gaggatgagg gacaacgaaa aaggatgtca gcatgtcgtg cgagcagacc gcggtcatat gaagagctga catcttggga gaagtacatg ccccatcaca gggctggttg tctcattaaa gcataagaaa actaccagct cacatgtagt tgggccatgg tgaggagaca gccattgctg gtcatacacc gtgataacag ggggtgtgca gtgaccacat gttaagcctg ggcat tgaagatggt catttacata ggtcaaccag ccccagcaaa tggtggctgt acaggatgaa ctgcgtaggc tggaatagca ggtgagaatt agaaacctag caaggataaa

300

360

420

480

540

600

660

720

780

840

900

945 <210> 3208 <211> 314 <212> PRT <213> Felis catus <400> 3208

Met Pro Leu Met Arg Met Ala Ala Glu Asn Ser Ser Val Thr Glu Phe 1 5 10 15 Ile Leu Ala Gly Leu Thr Asn Gln Pro Gly Leu Arg Met Pro Leu Phe 20 25 30 Phe Leu Phe Leu Gly Phe Tyr Val Val Thr Val Met Gly Asn Leu Gly 35 40 45 Leu Ile Thr Leu Ile Gly Leu Asn Ser His Leu His Thr Pro Met Tyr 50 55 60 Phe Phe Leu Phe Asn Leu Ser Phe Ile Asp Phe Cys Tyr Ser Thr Val 65 70 75 80 Ile Thr Pro Lys Met Leu Met Ser Phe Val Ser Lys Asn Thr Ile Ala Page 358 4

069269_0225_SL.TXT

85 90 95 Tyr Ala Gly Cys Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val Val 100 105 110 Ser Glu Ser Phe Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Thr Ala 115 120 125 Ile Cys Asn Pro Leu Val Tyr Thr Ala Thr Met Ser Pro Gln Val Cys 130 135 140 Ser Leu Leu Leu Leu Gly Val Tyr Val Met Gly Phe Ala Gly Ala Met 145 150 155 160 Ala His Thr Thr Cys Met Val Arg Leu Thr Phe Cys Ala Asn Asn Leu 165 170 175 Val Asp His Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Arg Ser Cys 180 185 190 Thr Ser Thr Tyr Val Asn Glu Leu Val Val Phe Val Val Val Gly Ile 195 200 205 Asp Ile Gly Val Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu Ile 210 215 220 Leu Thr Ser Ile Leu His Ile Arg Ser Thr Glu Gly Arg Ser Lys Ala 225 230 235 240 Phe Ser Thr Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly 245 250 255 Ser Gly Ala Phe Met Tyr Leu Lys Pro Ser Ser Leu Leu Pro Met Asn 260 265 270 Gln Gly Lys Val Ser Ser Leu Phe Tyr Thr Thr Val Val Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu

Page 3585

069269_0225_SL.TXT

290 295 300

Lys Lys Ser Leu Ser Lys Lys Thr Phe Ser

305 310 <210> 3209 <211> 930 <212> DNA <213> Felis catus <400> 3209 gaagaatttt ctgcctaagg tcttcttcag ggcaactttg acatccttgt tcctcagact 60 atagattaat gggttgaaca tgggcaccac agcagtatag aatatggagg acactttccc 120 ctggtcaagg ggtaaaatag aaggtggttt gaggtacata aaagctcctg atccaaagaa 180 aagagatacc acaattatat gggaactgca ggtactgaag gctttggatc tgccctcagt 240 agaactaata tggagaatac tagaaagaat gaaaccatag gagataaaaa tggtcacaat 300 gggtacccca atgccaatgg tcacaacaat gaagaccacc agcaaattta tgtaagagct 360 gttgcaggag agctcaagga ggggaatgat atcgcacata tagtggttga cgaagttgtc 420 agcacaaaag gttataaaca ttatgtttcc catatgggca acagctccaa acactcccat 480 cccataaaca cctaacaaaa ggagtgaaca cacctgagga gacatggtaa ctgtgtatag 540 cagtggttta cagatggcga catagcggtc atatgccatc gctgacaaga tgtaggattc 600 agaaaacaca aagaaacaga agaaaaaaaa ctgagtcata caccctgcat aggaaatgat 660 gtttctcttt gcgacaaaac ccattagcat tttaggggtc agagtcgtgg agtaactaac 720 atctatgaag gacaagttga agaggaaaaa gtacatggga atatgaaggt gagaattcag 780 cccaatcagg gttatcaggc ccaggttccc caccacagtg accatgtaga aacctagaaa 840 caggaagaag aggggcatct ggagttctgg ctcatctgtt aagcctgcga ggataaactc 900 tgtcacagag gaggcattat ctgtagccat 930 <210> 3210 <211> 310 <212> PRT <213> Felis catus <400> 3210

Page 3586

069269_0225_SL.TXT

Met 1 Ala Thr Asp Asn 5 Ala Ser Ser Val Thr Glu Phe Ile Leu Ala Gly 10 15 Leu Thr Asp Glu Pro Glu Leu Gln Met Pro Leu Phe Phe Leu Phe Leu 20 25 30 Gly Phe Tyr Met Val Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Ile Gly Leu Asn Ser His Leu His Ile Pro Met Tyr Phe Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Val Ser Tyr Ser Thr Thr Leu Thr Pro Lys 65 70 75 80 Met Leu Met Gly Phe Val Ala Lys Arg Asn Ile Ile Ser Tyr Ala Gly 85 90 95 Cys Met Thr Gln Phe Phe Phe Phe Cys Phe Phe Val Phe Ser Glu Ser 100 105 110 Tyr Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125 Pro Leu Leu Tyr Thr Val Thr Met Ser Pro Gln Val Cys Ser Leu Leu 130 135 140 Leu Leu Gly Val Tyr Gly Met Gly Val Phe Gly Ala Val Ala His Met 145 150 155 160 Gly Asn Ile Met Phe Ile Thr Phe Cys Ala Asp Asn Phe Val Asn His 165 170 175 Tyr Met Cys Asp Ile Ile Pro Leu Leu Glu Leu Ser Cys Asn Ser Ser 180 185 190 Tyr Ile Asn Leu Leu Val Val Phe Ile Val Val Thr Ile Gly Ile Gly 195 200 205

Page 3587

Val Pro 210 Ile Val Thr Ile Phe 215 069269_0225_SL.TXT Ile Ser Tyr Gly Phe Ile 220 Leu Ser Ser Ile Leu His Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ile Val Val Ser Leu Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu Lys Pro Pro Ser Ile Leu Pro Leu Asp Gln Gly Lys 260 265 270 Val Ser Ser Ile Phe Tyr Thr Ala Val Val Pro Met Phe Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Lys Lys Thr 290 295 300 Leu Gly Arg Lys Phe Phe

305 310

<210> 3211 <211> 936 <212> DNA <213> Felis catus <400> 3211 tcaagagaag gttattctgc ccacagtttt cctcagggca actttgacat ccttattcct 60 cagactgtag attaatgggt tgaacattgg cacaacaatg gtgtagaaca aggaagacac 120 tttcccctgg tcaaggggta aaatagaagg tggcttgagg tacataaaag ctcctgatcc 180 aaagaaaaga gaaactgcaa ttatgtgaga actgcaggta ctgaaggcct tggacctgcc 240 ttcagtggag ctaatgtgga aaatgctaga aataatgaag ccataagata taaaaatggc 300 aacaatgggc accccaatgc caatggtcac aacaataaag acaattagta catttatgta 360 agagctgttg caagagagct caaggagggg aaggatgtca cacatatagt gattaacaag 420 gttgtcagaa caaaatgtca gaaataatat atttcctgta tgggccacag ctcccaaaat 480 ccccatccca tagacaccca gtaaaaggag taaacacacc tgagaagaca cagtgaccat 540

Page 3588

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gtacagcagt ggtttacaga tggcgacata gcggtcatat gccatcgctg acaggatgta 600 ggattcagaa aagacaaaaa agcaaaagaa aaagagctga gtcatacacc ctgcatagga 660 aatgatgttc ttcttggaga caaaactcat tagcattttg gggatgatgg cagtagagaa 720 actaaaatct atgaaggaca agttgaagag gaaaaagtac atgggaatat gaaggtgaga 780 attcagccca atcagggtta tcaggcccag gttccccacc acagtgacca tgtagaaacc 840 tagaaacagg aagaagaggg gcatctggag ttctggctca tctgttaagc ctgcgaggat 900 aaactctgtc acagaggagg cattatctgt agccat 936

<210> 3212 <211> 311 <212> PRT <213> Felis catus <400> 3212

Met Ala Thr Asp Asn Ala Ser Ser Val Thr Glu Phe Ile Leu Ala Gly 1 5 10 15 Leu Thr Asp Glu Pro Glu Leu Gln Met Pro Leu Phe Phe Leu Phe Leu 20 25 30 Gly Phe Tyr Met Val Thr Val Val Gly Asn Leu Gly Leu Ile Thr Leu 35 40 45 Ile Gly Leu Asn Ser His Leu His Ile Pro Met Tyr Phe Phe Leu Phe 50 55 60 Asn Leu Ser Phe Ile Asp Phe Ser Phe Ser Thr Ala Ile Ile Pro Lys 65 70 75 80 Met Leu Met Ser Phe Val Ser Lys Lys Asn Ile Ile Ser Tyr Ala Gly 85 90 95 Cys Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Phe Ser Glu Ser 100 105 110 Tyr Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys 115 120 125

Page 3589

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Pro Leu 130 Leu Tyr Met Val Thr Val Ser Ser Gln Val Cys Leu Leu Leu 135 140 Leu Leu Gly Val Tyr Gly Met Gly Ile Leu Gly Ala Val Ala His Thr 145 150 155 160 Gly Asn Ile Leu Phe Leu Thr Phe Cys Ser Asp Asn Leu Val Asn His 165 170 175 Tyr Met Cys Asp Ile Leu Pro Leu Leu Glu Leu Ser Cys Asn Ser Ser 180 185 190 Tyr Ile Asn Val Leu Ile Val Phe Ile Val Val Thr Ile Gly Ile Gly 195 200 205 Val Pro Ile Val Ala Ile Phe Ile Ser Tyr Gly Phe Ile Ile Ser Ser 210 215 220 Ile Phe His Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala 245 250 255 Phe Met Tyr Leu Lys Pro Pro Ser Ile Leu Pro Leu Asp Gln Gly Lys 260 265 270 Val Ser Ser Leu Phe Tyr Thr Ile Val Val Pro Met Phe Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Lys Thr 290 295 300 Val Gly Arg Ile Thr Phe Ser

305 310 <210> 3213 <211> 905 <212> DNA

Page 3590

069269_0225_SL.TXT <213> Felis catus <400> 3213 gtgaccgagt ttattctcag gggattgaca aatcggccag agctccagct ccccctcttc 60 ctcctcttcc ttgggatcta cttggtcacc gtcataggga acctgggcat gttcacgctg 120 atttgtctga atgctcagct tcacaccccc atgtactact tcctcagcaa tctgtccctt 180 gtggatctct gctactcctc tgtcattacc ccgaaaatgc tggtgaactt tgtgtcagag 240 aagaacatca tctcctatgc ggggtgcatg tcacagctct acttcttcct tgtgtttgtc 300 attggtgagt gttacatgtt gacagtgatg gcctatgacc gctatgtcgc catctgcagc 360 ccattgctct accatgtcat catgtctcct caagtgtgtt ccctgctggt gtctgtggtc 420 tatgccatgg gatttattgg tgcaacaata gagactggcc tgatgttaaa actgtcctac 480 tgtgagctcc tcatcagcca ttacttctgt gacatcctcc ctctcataaa gctctcctgc 540 tctagcacct atcatattga gatgacagtg ttctttttgg ctggattcaa catcatagtc 600 accagcttaa cagtccttgt ttcctacgtc ttcatcctct ccagcatcct ccacatcagc 660 accacacagg gaaggtccaa agccttcagc acctgcagct ctcaccttgc agctgtggta 720 atgttctatg gatctactgc atttatgtac ttaaaaccct ccacggccag ttctgtggcc 780 aaggagaatg tggcctccgt gttctacacc acggtgatcc ccatgctgaa ccccctgatc 840 tacagcttga ggaataagga ggtaaagact accgtgcaga aaacactgag gagaatactc 900 ttcag 905 <210> 3214 <211> 302 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (302)..(302) <223> Any amino acid <400> 3214

Val Thr Glu Phe Ile Leu Arg Gly Leu Thr Asn Arg Pro Glu Leu Gln 1 5 10 15

Page 3591

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Leu Pro Leu Phe 20 Leu Leu Phe Leu Gly Ile Tyr Leu Val Thr Val Ile 25 30 Gly Asn Leu Gly Met Phe Thr Leu Ile Cys Leu Asn Ala Gln Leu His 35 40 45 Thr Pro Met Tyr Tyr Phe Leu Ser Asn Leu Ser Leu Val Asp Leu Cys 50 55 60 Tyr Ser Ser Val Ile Thr Pro Lys Met Leu Val Asn Phe Val Ser Glu 65 70 75 80 Lys Asn Ile Ile Ser Tyr Ala Gly Cys Met Ser Gln Leu Tyr Phe Phe 85 90 95 Leu Val Phe Val Ile Gly Glu Cys Tyr Met Leu Thr Val Met Ala Tyr 100 105 110 Asp Arg Tyr Val Ala Ile Cys Ser Pro Leu Leu Tyr His Val Ile Met 115 120 125 Ser Pro Gln Val Cys Ser Leu Leu Val Ser Val Val Tyr Ala Met Gly 130 135 140 Phe Ile Gly Ala Thr Ile Glu Thr Gly Leu Met Leu Lys Leu Ser Tyr 145 150 155 160 Cys Glu Leu Leu Ile Ser His Tyr Phe Cys Asp Ile Leu Pro Leu Ile 165 170 175 Lys Leu Ser Cys Ser Ser Thr Tyr His Ile Glu Met Thr Val Phe Phe 180 185 190 Leu Ala Gly Phe Asn Ile Ile Val Thr Ser Leu Thr Val Leu Val Ser 195 200 205 Tyr Val Phe Ile Leu Ser Ser Ile Leu His Ile Ser Thr Thr Gln Gly 210 215 220

Page 3592

Arg 225 Ser Lys Ala Phe Ser 230 Thr 069269_0225_SL.TXT Ala Val Val 240 Cys Ser Ser His 235 Leu Ala Met Phe Tyr Gly Ser Thr Ala Phe Met Tyr Leu Lys Pro Ser Thr Ala 245 250 255 Ser Ser Val Ala Lys Glu Asn Val Ala Ser Val Phe Tyr Thr Thr Val 260 265 270 Ile Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu Val 275 280 285 Lys Thr Thr Val Gln Lys Thr Leu Arg Arg Ile Leu Phe Xaa 290 295 300

<210> 3215 <211> 936 <212> DNA <213> Felis catus <400> 3215

tcaagaagat atttttcttt ccaaggtgtt cctcagggaa actttgacat ccttgttcct 60 caaactgtag atcagtgggt ttaacatggg caccacaatg gtatagaaca gagaggacac 120 tttcccttgg tcaaggggca aaatagaagg tggtttgaga tacatgaaag ccccagaacc 180 aaagaaaaga gaaaccacaa ttatatgaga gctacatgta ctgaaagctt tggacctgcc 240 ctcagtggag tgaatgtgca gaatgctgga cagaatcaga gcataagaga tgaagatggt 300 gataatgggc attccaatgt caatggccac aaggatgaag accaccagtt catttacata 360 agtgctgttg caggacagct cgaggagagg aaggatgtca cacatgaaat gattgagaag 420 gttgtcagca cagaaggtca gacttgctat gcttcccgta tggaccatag cccctgaaag 480 ccccatcacg tagacaccca acaaaaggaa tagacagacc tgaggagaca tggtgaccat 540 gtacaccaat ggtttacaga tggccacata gcggtcatat gccatcactg acaggaggaa 600 ggactcagaa atgacaaaga agcagaagaa aaagagttga gtcatacact ctgcatgcaa 660 gatgatgttc ttctttgaga caaaactctt cagcattttg ggggtgatgg tagtggagta 720 gcagaaatct attaaggaga ggttgaagag gaaaaagtac attggggtgt gtaggcaaga 780

Page 3593

069269_0225_SL.TXT attcaaccga atcagggcta tcaaggccag gtttcccagc acagtgacca tgtagaaacc tagaaacagg aagaagagag ggatctggag ttccagctgg tctgttaaac ctgtaaggat aaactctgtc acagaagagt tcttagctgc cattct

840

900

936 <210> 3216 <211> 310 <212> PRT <213> Felis catus <400> 3216

Met Ala 1 Ala Lys Asn Ser Ser Val Thr Glu Phe Ile Leu Thr Gly Leu 5 10 15 Thr Asp Gln Leu Glu Leu Gln Ile Pro Leu Phe Phe Leu Phe Leu Gly 20 25 30 Phe Tyr Met Val Thr Val Leu Gly Asn Leu Ala Leu Ile Ala Leu Ile 35 40 45 Arg Leu Asn Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Phe Asn 50 55 60 Leu Ser Leu Ile Asp Phe Cys Tyr Ser Thr Thr Ile Thr Pro Lys Met 65 70 75 80 Leu Lys Ser Phe Val Ser Lys Lys Asn Ile Ile Leu His Ala Glu Cys 85 90 95 Met Thr Gln Leu Phe Phe Phe Cys Phe Phe Val Ile Ser Glu Ser Phe 100 105 110 Leu Leu Ser Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro 115 120 125 Leu Val Tyr Met Val Thr Met Ser Pro Gln Val Cys Leu Phe Leu Leu 130 135 140 Leu Gly Val Tyr Val Met Gly Leu Ser Gly Ala Met Val His Thr Gly 145 150 155 160

Page 3594

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Ser Ile Ala Ser Leu Thr Phe Cys Ala Asp Asn Leu Leu Asn His Phe 165 170 175 Met Cys Asp Ile Leu Pro Leu Leu Glu Leu Ser Cys Asn Ser Thr Tyr 180 185 190 Val Asn Glu Leu Val Val Phe Ile Leu Val Ala Ile Asp Ile Gly Met 195 200 205 Pro Ile Ile Thr Ile Phe Ile Ser Tyr Ala Leu Ile Leu Ser Ser Ile 210 215 220 Leu His Ile His Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Ile Ile Val Val Ser Leu Phe Phe Gly Ser Gly Ala Phe 245 250 255 Met Tyr Leu Lys Pro Pro Ser Ile Leu Pro Leu Asp Gln Gly Lys Val 260 265 270 Ser Ser Leu Phe Tyr Thr Ile Val Val Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ser Leu Arg Asn Thr Leu 290 295 300 Glu Arg Lys Ile Ser Ser

305 310 <210> 3217 <211> 921 <212> DNA <213> Felis catus <400> 3217 atggctgccg aaaatcactc tacagtgacc gagtttattc tcaggggatt gacaaatcgg ccagagctcc agctccctct cttcctcctc ttccttggga tctacttggt caccatcata gggaacctgg gcatgttcac actgatttgt ctgaatgctc agcttcacac ccccatgtac Page 3595

120

180

069269_0225_SL.TXT

tacttcctca gcaatctgtc ccttgtggat ctctgctact cctctgtcat taccccgaaa 240 atgctggtga actttgtgtc agagaagaac atcatctcct atgcggggtg catgtcacag 300 ctctacttct tcattgtgtt tgtcgtggca gagtgttaca tgctgacagt gatggcctat 360 gactgctatg tcgccatcta tacccctttg ctctacaatg tcatcatgtc tcctcaagtg 420 tgttccctgc tgatggctgc ggcctatgcc atggctttca ttggcgcaac aatagacact 480 ggcctgatgt taaaactgtc ctactgtgag ttcctcatca gtcattactt ctgtgacatt 540 gtgcccctca tgaagctctc ctgctctagc acctatcata ttgagatgac agtgttcttt 600 ttggctggat tcaacatcat agccaccagc ttaacagtcc ttgtttccta cgtcttcatc 660 ctctccagca tcctccacat cagcaccaca cagggaaggt ccaaagcctt cagcacctgc 720 agctctcacc ttgcagctgt gggaatgttc tatggatcta cagcgttcat gtacttaaaa 780 ccctccacgg ccagttctgt ggccaaggag aatgtggcct ccgtgttcta caccacggtg 840 atccccatgc tgaaccccct gatctacagc ttgaggaata aggaggtaaa ggctgccgtg 900 cagaaaacac tgaggagaaa a 921

<210> 3218 <211> 307 <212> PRT <213> Felis catus

<400> 3218 Met Ala Ala Glu 1 Asn 5 His Ser Thr Val Thr Glu Phe Ile Leu Arg Gly 10 15 Leu Thr Asn Arg Pro Glu Leu Gln Leu Pro Leu Phe Leu Leu Phe Leu 20 25 30 Gly Ile Tyr Leu Val Thr Ile Ile Gly Asn Leu Gly Met Phe Thr Leu 35 40 45 Ile Cys Leu Asn Ala Gln Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Asn Leu Ser Leu Val Asp Leu Cys Tyr Ser Ser Val Ile Thr Pro Lys 65 70 75 80

Page 3596

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Met Leu Val Asn Phe Val Ser Glu Lys Asn Ile Ile Ser Tyr Ala Gly 85 90 95 Cys Met Ser Gln Leu Tyr Phe Phe Ile Val Phe Val Val Ala Glu Cys 100 105 110 Tyr Met Leu Thr Val Met Ala Tyr Asp Cys Tyr Val Ala Ile Tyr Thr 115 120 125 Pro Leu Leu Tyr Asn Val Ile Met Ser Pro Gln Val Cys Ser Leu Leu 130 135 140 Met Ala Ala Ala Tyr Ala Met Ala Phe Ile Gly Ala Thr Ile Asp Thr 145 150 155 160 Gly Leu Met Leu Lys Leu Ser Tyr Cys Glu Phe Leu Ile Ser His Tyr 165 170 175 Phe Cys Asp Ile Val Pro Leu Met Lys Leu Ser Cys Ser Ser Thr Tyr 180 185 190 His Ile Glu Met Thr Val Phe Phe Leu Ala Gly Phe Asn Ile Ile Ala 195 200 205 Thr Ser Leu Thr Val Leu Val Ser Tyr Val Phe Ile Leu Ser Ser Ile 210 215 220 Leu His Ile Ser Thr Thr Gln Gly Arg Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Ala Ala Val Gly Met Phe Tyr Gly Ser Thr Ala Phe 245 250 255 Met Tyr Leu Lys Pro Ser Thr Ala Ser Ser Val Ala Lys Glu Asn Val 260 265 270 Ala Ser Val Phe Tyr Thr Thr Val Ile Pro Met Leu Asn Pro Leu Ile 275 280 285

Page 3597

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Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Val Gln Lys Thr Leu 290 295 300

Arg Arg Lys

305 <210> 3219 <211> 918 <212> DNA <213> Felis catus <400> 3219

ctgtaatgga tcagagaact actcactggt cttctacctg gtaggcatcc tgtctctgca 60 tgaatctttc ttcctccctg tcttcttgat tttcctctta atttacctgc tcatcctgct 120 gggaaatgcc tgatcctgtt ggctgtggtg gcagagccca gcctccacaa gcccatgtac 180 ttcttcctga tcagctctga gccttggaca ttctactaca accgtcgtcc ccaaaatgtc 240 atccttattc ttacttgggg accacttcct cagcttccct gcctgcttcc tgcagatgta 300 cctcttccat agcttctcct actcagaagc cttcatcctg gtggtcatgg cctatgactg 360 ctacgtggct gtctgccacc cactgcacta ccctgtcctc atgactccac agaccaatgc 420 tgcactggca gcctgtgcct ggctcactgc cctcctcctg gccaacccag cagtggtgca 480 gacttcccac atggcttttg acaacactgc tcacatctat cactgcttct gtgaccacct 540 ggctgtggtc caggcctctt gctcggacac catgcctcat gggcttctgt atcgccatgg 600 cagtatcctt cctgcccctt gtcctggtgc ttctctccta tgcccacatc ctggcctcgg 660 tgcttcacat cagctcccga gaaggatgct cagaagtctt ctccacctac agctcctaca 720 tcctggtggt tggcacctac tacttatcca ttgccatagc ctatgtggcc tacagagcta 780 acctgccact cgacttccac atcatgggca atgtggtata tgctattctc acacctgtcc 840 tcaaccctct catctatgcg ctgaggaaca aggatgtcaa agcagccatc accagaatgg 900 catgtcccca ggacccag 918

<210> 3220 <211> 168 <212> PRT

Page 3598

069269_0225_SL.TXT <213> Felis catus <220>

<221> MOD_RES <222> (168)..(168) <223> Any amino acid <400> 3220

Met 1 Leu His Trp Gln 5 Pro Val Pro Gly Ser Leu Pro Ser Ser Trp Pro 10 15 Thr Gln Gln Trp Cys Arg Leu Pro Thr Trp Leu Leu Thr Thr Leu Leu 20 25 30 Thr Ser Ile Thr Ala Ser Val Thr Thr Trp Leu Trp Ser Arg Pro Leu 35 40 45 Ala Arg Thr Pro Cys Leu Met Gly Phe Cys Ile Ala Met Ala Val Ser 50 55 60 Phe Leu Pro Leu Val Leu Val Leu Leu Ser Tyr Ala His Ile Leu Ala 65 70 75 80 Ser Val Leu His Ile Ser Ser Arg Glu Gly Cys Ser Glu Val Phe Ser 85 90 95 Thr Tyr Ser Ser Tyr Ile Leu Val Val Gly Thr Tyr Tyr Leu Ser Ile 100 105 110 Ala Ile Ala Tyr Val Ala Tyr Arg Ala Asn Leu Pro Leu Asp Phe His 115 120 125 Ile Met Gly Asn Val Val Tyr Ala Ile Leu Thr Pro Val Leu Asn Pro 130 135 140 Leu Ile Tyr Ala Leu Arg Asn Lys Asp Val Lys Ala Ala Ile Thr Arg 145 150 155 160 Met Ala Cys Pro Gln Asp Pro Xaa 165

Page 3599

069269_0225_SL.TXT <210> 3221 <211> 948 <212> DNA <213> Felis catus <400> 3221

atggaggcca caacttgtaa tggatcagtg gatggatcac cagtcttcta tctggtggga 60 atcccctctt tgccagagac cttcttcctc cctatgtttt ttattttcct cctcttctat 120 cttctcatcc ttatgggaaa tgccctgatc ctggtggctg tggtggcaga gcccagcctc 180 cacaagccca tgtacttctt cctgatcaat ctctctactc tggacattct cttcaccaca 240 accactgtcc ccaagatgct gtccttattc ctgcttggag accacttcct cagcttccct 300 gcttgcttat tgcaaatgta cctcttccaa ggcttcacat gttcagaagc cttcatcttg 360 gtggtcatgg cctatgaccg ctatgtggct atctgccgcc cactgcacta ccctgtccac 420 atgaccccac agaccaatgc ttcactggca gcctgtgcct ggcttaccgc cctcctcctg 480 cccatcccag cagtagtcaa gacctcccag atggcatata acaacattgc tcagatctac 540 cattgtttct gtgatcattt agctctggtt caggcttcct gctctgacac catgccccag 600 accctcatgg gcttctgtat tgctatggtg gtatccttcc tgccccttct cctggtgctt 660 ctttcctatg cccacatcct ggcctcggtg cttcgcatca gctcccgaga aggacgctca 720 aaagccttct ccacctgcag ctcccacctc ctggtggttg gcacctacta ttcatccatc 780 gccatagcct atgtggccta cagggctgac ttgccgctcg acttccacat catgggcaac 840 gtagcatatt ctattctcac accaatcctc aaccctctca tttacactct gagaaacaag 900 gatgtcaagg cagccattac gaaaatcaca tctctcaaga cccagtct 948

<210> 3222 <211> 316 <212> PRT <213> Felis catus

<400> 3222 Met Glu Ala Thr Thr Cys Asn Gly Ser Val Asp Gly Ser Pro Val Phe 1 5 10 15 Tyr Leu Val Gly Ile Pro Ser Leu Pro Glu Thr Phe Phe Leu Pro Met 20 25 30

Page 3600

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Phe Phe Ile 35 Phe Leu Leu Phe Tyr Leu Leu Ile Leu Met Gly Asn Ala 40 45 Leu Ile Leu Val Ala Val Val Ala Glu Pro Ser Leu His Lys Pro Met 50 55 60 Tyr Phe Phe Leu Ile Asn Leu Ser Thr Leu Asp Ile Leu Phe Thr Thr 65 70 75 80 Thr Thr Val Pro Lys Met Leu Ser Leu Phe Leu Leu Gly Asp His Phe 85 90 95 Leu Ser Phe Pro Ala Cys Leu Leu Gln Met Tyr Leu Phe Gln Gly Phe 100 105 110 Thr Cys Ser Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr 115 120 125 Val Ala Ile Cys Arg Pro Leu His Tyr Pro Val His Met Thr Pro Gln 130 135 140 Thr Asn Ala Ser Leu Ala Ala Cys Ala Trp Leu Thr Ala Leu Leu Leu 145 150 155 160 Pro Ile Pro Ala Val Val Lys Thr Ser Gln Met Ala Tyr Asn Asn Ile 165 170 175 Ala Gln Ile Tyr His Cys Phe Cys Asp His Leu Ala Leu Val Gln Ala 180 185 190 Ser Cys Ser Asp Thr Met Pro Gln Thr Leu Met Gly Phe Cys Ile Ala 195 200 205 Met Val Val Ser Phe Leu Pro Leu Leu Leu Val Leu Leu Ser Tyr Ala 210 215 220 His Ile Leu Ala Ser Val Leu Arg Ile Ser Ser Arg Glu Gly Arg Ser 225 230 235 240

Page 3601

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Lys Ala Phe Ser Thr Cys Ser Ser His Leu 250 Leu Val Val Gly Thr 255 Tyr 245 Tyr Ser Ser Ile Ala Ile Ala Tyr Val Ala Tyr Arg Ala Asp Leu Pro 260 265 270 Leu Asp Phe His Ile Met Gly Asn Val Ala Tyr Ser Ile Leu Thr Pro 275 280 285 Ile Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Lys Asp Val Lys Ala 290 295 300 Ala Ile Thr Lys Ile Thr Ser Leu Lys Thr Gln Ser 305 310 315

<210> 3223 <211> 923 <212> DNA <213> Felis catus <400> 3223

atggagacta gagcctataa tggatcagag gactcctcaa ccatcttcta cctggtggga 60 attccctctc tacccaaatc tttctttctt cctatcttct ttatctttct cctactctac 120 ttactcatcc tgctgggaaa tgccctgatc ctggtggctg tggtggcaga gcccagcctc 180 cacatgccca tgtacttctt cctgatcaac ctctcagcct tgcgcatcct tttcaccaca 240 accaccatct ccaagatact gtccctcctc ttactggggg actgcttcct cagcttccct 300 gcctgcttcc tgcagatgta cctcttctat agcttctcct actcagaagc cttcatcctg 360 gtggtcatgg cctatgaccg ctatgtggct gtctgccacc cactgcacta ccctgtcctc 420 aggactccac agaccaatgc tgcactggca gcctgtgtct gctcactgcc ctcctccggc 480 ccaccccagt ggtggtgcag acttcccaca tggcttttga caacactgtt cacatctatc 540 actgcttctg tgaccacctg gctgtggttt aggcctcctg cttagcccca ggctctcatg 600 ggcttctgca tcgccatggc agtatccttc ctgccccttg tcctggtgct tctctcctat 660 gcccacatcc tggcctcggt gcttcgcatc tgctcccgag aaggacgctc agaagacttc 720

Page 3602 tccacctgca tatgtggcct gctattctca agccatcacc gctcccacct acagcgctaa tacctgtcct agaacggaat

069269_0225_SL.TXT cctggtggtt ggcacctact acttatccat tgccatagcc cctgccactc gacttccaca tcatgggcaa tgtggtatat caaccctctc atctatgctg aggaacaaga atgtcaaagc gtc

780

840

900

923 <210> 3224 <211> 194 <212> PRT <213> Felis catus

<400> 3224 Met Glu Thr 1 Arg Ala Tyr Asn Gly Ser Glu Asp Ser Ser Thr Ile Phe 15 5 10 Tyr Leu Val Gly Ile Pro Ser Leu Pro Lys Ser Phe Phe Leu Pro Ile 20 25 30 Phe Phe Ile Phe Leu Leu Leu Tyr Leu Leu Ile Leu Leu Gly Asn Ala 35 40 45 Leu Ile Leu Val Ala Val Val Ala Glu Pro Ser Leu His Met Pro Met 50 55 60 Tyr Phe Phe Leu Ile Asn Leu Ser Ala Leu Arg Ile Leu Phe Thr Thr 65 70 75 80 Thr Thr Ile Ser Lys Ile Leu Ser Leu Leu Leu Leu Gly Asp Cys Phe 85 90 95 Leu Ser Phe Pro Ala Cys Phe Leu Gln Met Tyr Leu Phe Tyr Ser Phe 100 105 110 Ser Tyr Ser Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr 115 120 125 Val Ala Val Cys His Pro Leu His Tyr Pro Val Leu Arg Thr Pro Gln 130 135 140 Thr Asn Ala Ala Leu Ala Ala Cys Val Cys Ser Leu Pro Ser Ser Gly

Page 3603

06926 9_02 25_S L.TX T 145 150 155 160 Pro Pro Gln Trp Trp Cys Arg Leu Pro Thr Trp Leu Leu Thr Thr Leu 165 170 175 Phe Thr Ser Ile Thr Ala Ser Val Thr Thr Trp Leu Trp Phe Arg Pro 180 185 190

Pro Ala <210> 3225 <211> 1033 <212> DNA <213> Felis catus <400> 3225

caagttgata aagtcctttc actctggcag ttgcccctcc actctcatat tctgtagtct 60 ctggcttctc cccaacctcc tgggctgatt tattgccata gagcatcttt tccacatgtt 120 gccggatctc cctggtctgt actccataaa tgataggatt caaggatcct gggagtagca 180 agtagatggc actgagcagg ttctggacat ccggagacac agtcttggcc actcggaaga 240 caatggaggt agagagacca gagaggtaga tagtgaggat gaccagtaag tgggagccac 300 atgtgtgcaa ggccttggct cgggctctcc cagaagagat ccagaaggca gcatagatga 360 tgcgtgtata ggaggtccct agcagggcta gatccaaggt cacagtgacc aaccgcatgg 420 tcagtcccaa cccattgttg aaagtcaagt ctccacaagc tatgctcagc agtgcaatgt 480 actcacaggc aaagtgtcga atcaccattg tctggcagaa tcgacctcgt gacgttagca 540 ccaccaaagg cactgccact tccaggctcc gtgtcagagc aagaatggcc agcactccca 600 gcaggcggga agttatcagg tcagtatagt ggagtgggtg acagatggcc acgtagcggt 660 ctagggccat ggccagcagg atattgtagt ccaggagaga aaagtagata aagaacatct 720 ggtccaggca gccatgcagt gacatggggt tagcataatg cacaaagccc tccagcattt 780 tgggcatcac ggctgtggca gcacaaatgt tgacagccag gagcagggcg atgagcatgt 840 acatgggttg atgcaaactc cgttgggcca ccaccgtgtg gatgaccagg acgtttgcag 900 agatgatcgt cacataaagg aaggtaagag gcaggaccag gaggggctgc cactctcgca 960

Page 3604

069269_0225_SL.TXT atccagggaa gcccaccagg aagaagttgg tgtaggagat gctgaaggca ctggtatctc cattctcacc cat

1020

1033 <210> 3226 <211> 345 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (345)..(345) <223> Any amino acid <400> 3226

Met 1 Gly Glu Asn Gly 5 Asp Thr Ser Ala Phe Ser Ile Ser Tyr Thr Asn 10 15 Phe Phe Leu Val Gly Phe Pro Gly Leu Arg Glu Trp Gln Pro Leu Leu 20 25 30 Val Leu Pro Leu Thr Phe Leu Tyr Val Thr Ile Ile Ser Ala Asn Val 35 40 45 Leu Val Ile His Thr Val Val Ala Gln Arg Ser Leu His Gln Pro Met 50 55 60 Tyr Met Leu Ile Ala Leu Leu Leu Ala Val Asn Ile Cys Ala Ala Thr 65 70 75 80 Ala Val Met Pro Lys Met Leu Glu Gly Phe Val His Tyr Ala Asn Pro 85 90 95 Met Ser Leu His Gly Cys Leu Asp Gln Met Phe Phe Ile Tyr Phe Ser 100 105 110 Leu Leu Asp Tyr Asn Ile Leu Leu Ala Met Ala Leu Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu His Tyr Thr Asp Leu Ile Thr Ser Arg Leu

130 135 140

Page 3605

069269_0225_SL.TXT

Leu 145 Gly Val Leu Ala Ile Leu Ala Leu Thr Arg Ser Leu Glu Val Ala 150 155 160 Val Pro Leu Val Val Leu Thr Ser Arg Gly Arg Phe Cys Gln Thr Met 165 170 175 Val Ile Arg His Phe Ala Cys Glu Tyr Ile Ala Leu Leu Ser Ile Ala 180 185 190 Cys Gly Asp Leu Thr Phe Asn Asn Gly Leu Gly Leu Thr Met Arg Leu 195 200 205 Val Thr Val Thr Leu Asp Leu Ala Leu Leu Gly Thr Ser Tyr Thr Arg 210 215 220 Ile Ile Tyr Ala Ala Phe Trp Ile Ser Ser Gly Arg Ala Arg Ala Lys 225 230 235 240 Ala Leu His Thr Cys Gly Ser His Leu Leu Val Ile Leu Thr Ile Tyr 245 250 255 Leu Ser Gly Leu Ser Thr Ser Ile Val Phe Arg Val Ala Lys Thr Val 260 265 270 Ser Pro Asp Val Gln Asn Leu Leu Ser Ala Ile Tyr Leu Leu Leu Pro 275 280 285 Gly Ser Leu Asn Pro Ile Ile Tyr Gly Val Gln Thr Arg Glu Ile Arg 290 295 300 Gln His Val Glu Lys Met Leu Tyr Gly Asn Lys Ser Ala Gln Glu Val 305 310 315 320 Gly Glu Lys Pro Glu Thr Thr Glu Tyr Glu Ser Gly Gly Ala Thr Ala 325 330 335 Arg Val Lys Gly Leu Tyr Gln Leu Xaa 340 345

Page 3606

069269_0225_SL.TXT <210> 3227 <211> 908 <212> DNA <213> Felis catus <400> 3227 ttggaacaga gttgccaggt gctgcctgat ttccttggtc ccggccccgt agatgacagg 60 gttaactaga catgggagca gcaggtagag ggcgctgagt gagttgtgca tggccaggga 120 ggcggtggga gccacacggt agatgatgga tcaggacatg gtggaagagt agacggtgaa 180 gatgaccagc aggtgggagc cacaggtgtt cagggccttg gaatgtgctc tgcctgatga 240 aatccagaag gcagcatggg tgatgcgaga gtaggaggct ccaggtagca gcatgtccag 300 gactctgttg aagatgtgga cagtgagacc cacagtcttg ttcggggaga tgtccccact 360 ggagagcttc atgagggcca tgtgctcaca ggcaaagtgg tggatcaggt ctgagcagca 420 gaagtgaacc tgggaggcaa gccccacgag ggggggggca acaatgcaag tgctcctggc 480 agctgccgcc cccaccaggc cagccagcaa ctgacccgtc actatctcag ggtagcacag 540 agggtagcag atggcaatgt agcagtccag ggccatgacc aggaggatgt tgcagtcaaa 600 gacaatgagg aagtagatgc agaacatctg gagtagacag caaggcaggg agatgcggtt 660 gaagtgggta gagaagctga acagcatggt gcgcatcacg gtggcggcaa cacagatgct 720 gacagccagg agaagggaag tgagcaggta catgggctgg tgcaggctct gctgggccac 780 caccatgtgg gtgaccaggg cattggcaga gatgatcacc aggtagaggc tgaggaaggg 840 cagcaccaga agggcgcgag tgctcctgca gcccagggaa gcccacccag aggaagctgg 900 tgtaggac 908 <210> 3228 <211> 251 <212> PRT <213> Felis catus <400> 3228

Pro Thr Pro Ala Ser Ser Gly Trp Ala Ser Leu Gly Cys Arg Ser Thr

1 5 10 15

Arg Ala Leu Leu Val Leu Pro Phe Leu Ser Leu Tyr Leu Val Ile Ile

Page 3607

069269_0225_SL.TXT 25 30

Ser Ala Asn 35 Ala Leu Val Thr His Met Val Val Ala Gln Gln Ser Leu 40 45 His Gln Pro Met Tyr Leu Leu Thr Ser Leu Leu Leu Ala Val Ser Ile 50 55 60 Cys Val Ala Ala Thr Val Met Arg Thr Met Leu Phe Ser Phe Ser Thr 65 70 75 80 His Phe Asn Arg Ile Ser Leu Pro Cys Cys Leu Leu Gln Met Phe Cys 85 90 95 Ile Tyr Phe Leu Ile Val Phe Asp Cys Asn Ile Leu Leu Val Met Ala 100 105 110 Leu Asp Cys Tyr Ile Ala Ile Cys Tyr Pro Leu Cys Tyr Pro Glu Ile 115 120 125 Val Thr Gly Gln Leu Leu Ala Gly Leu Val Gly Ala Ala Ala Ala Arg 130 135 140 Ser Thr Cys Ile Val Ala Pro Pro Leu Val Gly Leu Ala Ser Gln Val 145 150 155 160 His Phe Cys Cys Ser Asp Leu Ile His His Phe Ala Cys Glu His Met 165 170 175 Ala Leu Met Lys Leu Ser Ser Gly Asp Ile Ser Pro Asn Lys Thr Val 180 185 190 Gly Leu Thr Val His Ile Phe Asn Arg Val Leu Asp Met Leu Leu Pro 195 200 205 Gly Ala Ser Tyr Ser Arg Ile Thr His Ala Ala Phe Trp Ile Ser Ser 210 215 220 Gly Arg Ala His Ser Lys Ala Leu Asn Thr Cys Gly Ser His Leu Leu

Page 3608

069269_0225_SL.TXT

225 230 235 240

Val Ile Phe Thr Val Tyr Ser Ser Thr Met Ser 245 250 <210> 3229 <211> 951 <212> DNA <213> Felis catus <400> 3229

atgatttcct taaaccacac tggtattagc cacacaatct tccacttcct gggcatccct 60 gggctagagg accagcatgt gtggatttcc atccccttct tcatttccta tgtcattgcc 120 ctgcttggga acagcctgct catctgcatt atcctcacaa agcacagcct ccacgaaccc 180 atgtacctct tcctctgcat gctggccgga gcagacgttg tcctctccac gtgcacagta 240 cctcaggcct tggccatctt ctggttccat gctggggaga tctccctgga tcgatgcatc 300 actcagttct tcattatcca ctgcactttc atctctgagt cagggatctt gctggtgatg 360 gcgtttgacc gctacattgc catatgctac ccactgagat acaccactat tcttacacat 420 gcactcattg ggaaaatcgg tgtgaccatc ttcctgagaa gtttttgtat gatcttcccc 480 ataatatttc ttttgaaaag attgactttc tgccaaaata agattattcc acacacctat 540 tgtgaacaca ttggcttggc caaatatgct tgtaatgaca ttagtgtgaa catctggtat 600 ggactttttg tcatcgtgtc tacagtggtc ttagatgtcc tgttaatttt tgtttcatat 660 ctgctgattc tccatgctgt cttccacatg ccttcacgag atgctcgcca caaagctctc 720 aacacatgtg gctcccatgt ctgcatcatt gtcctctttt atggccctgc gatcttcaca 780 acccttactc agcggtttgg acgccacatt ccacctcata ttcacatatt attggctaat 840 gtctgcattc ttgttccacc tatgctgaat cccatcattt atgggattaa gaccaagcaa 900 atccgagagc aggtggttca catatttttt ccaaagcaga aatgactttg g 951

<210> 3230 <211> 314 <212> PRT <213> Felis catus <400> 3230

Page 3609

069269_0225_SL.TXT

Met 1 Ile Ser Leu Asn 5 His Thr Gly Ile Ser His Thr Ile Phe His Phe 10 15 Leu Gly Ile Pro Gly Leu Glu Asp Gln His Val Trp Ile Ser Ile Pro 20 25 30 Phe Phe Ile Ser Tyr Val Ile Ala Leu Leu Gly Asn Ser Leu Leu Ile 35 40 45 Cys Ile Ile Leu Thr Lys His Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Cys Met Leu Ala Gly Ala Asp Val Val Leu Ser Thr Cys Thr Val 65 70 75 80 Pro Gln Ala Leu Ala Ile Phe Trp Phe His Ala Gly Glu Ile Ser Leu 85 90 95 Asp Arg Cys Ile Thr Gln Phe Phe Ile Ile His Cys Thr Phe Ile Ser 100 105 110 Glu Ser Gly Ile Leu Leu Val Met Ala Phe Asp Arg Tyr Ile Ala Ile 115 120 125 Cys Tyr Pro Leu Arg Tyr Thr Thr Ile Leu Thr His Ala Leu Ile Gly 130 135 140 Lys Ile Gly Val Thr Ile Phe Leu Arg Ser Phe Cys Met Ile Phe Pro 145 150 155 160 Ile Ile Phe Leu Leu Lys Arg Leu Thr Phe Cys Gln Asn Lys Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Ile Gly Leu Ala Lys Tyr Ala Cys Asn 180 185 190 Asp Ile Ser Val Asn Ile Trp Tyr Gly Leu Phe Val Ile Val Ser Thr 195 200 205

Page 3610

Val Val 210 Leu Asp Val Leu Leu 215 069269_0225_SL.TXT Ile Phe Val Ser Tyr Leu 220 Leu Ile Leu His Ala Val Phe His Met Pro Ser Arg Asp Ala Arg His Lys Ala Leu 225 230 235 240 Asn Thr Cys Gly Ser His Val Cys Ile Ile Val Leu Phe Tyr Gly Pro 245 250 255 Ala Ile Phe Thr Thr Leu Thr Gln Arg Phe Gly Arg His Ile Pro Pro 260 265 270 His Ile His Ile Leu Leu Ala Asn Val Cys Ile Leu Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Gly Ile Lys Thr Lys Gln Ile Arg Glu Gln 290 295 300 Val Val His Ile Phe Phe Pro Lys Gln Lys

305 310

<210> 3231 <211> 949 <212> DNA <213> Felis catus <400> 3231 atgactacct taaaccacac tgctgttagt cacatggtct tctgtttgct ggccattcct 60 ggccttgagg accagcatgt gtgggcttcc atccccttct tcatttccta tgtcatcgcc 120 ctgcttggga acagcctgct catctgcatt atcctcacaa agtgcagcct ccacgaaccc 180 atgtacctct tcctctgcat gccgggcgga gcagacattg tcctcttcac gtgcacagta 240 actcaggcct tggacatctt ctggttccgt gctggggaga tctctctgaa tcgctgcatc 300 acttagctct tcttcatcca taccaccttc atctctgagt cagggatctt gctggtgatg 360 gagtttgagt gctacattgc cgtatgctac ctactgagat acaccactat tcttacatgt 420 gcactgattg ggaaagttgg attgactatc tttctgagaa gttatggtac aattttccct 480 ataatgtttc ttctgaaaag attggctttt tgaaaaagta gcatcctccc aaacacagcc 540

Page 3611

069269_0225_SL.TXT

tgtaagcata ctgtcttggc ccgtgcttcc tgtaatgaca tatgactaaa catctggtat 600 gtggttttgt cctaatgtca acagtggtct tgggtatcgt gctaattttt atttcatatg 660 tgctgattct ccacgctgtc gtctgcatcc cttctggaga cgcttgtcac aaagctctca 720 atacttgcgg ctcccatgtc tgtgtcattg tcctctttta tggacctggg agctttacaa 780 cacttactca gcagtttgga tgccacatca caccccacat tcatgttctg ctggccagta 840 tctgcattct ggctcctcct atgctaaatc ccatcattta tgggataaag accaaacaga 900 tccgggacca ggtggtttat gcattgttta caaagcagaa ataattttg 949

<210> 3232 <211> 117 <212> PRT <213> Felis catus <400> 3232

Met Trp Phe Cys Pro Asn Val Asn Ser Gly Leu Gly Tyr Arg Ala Asn 1 5 10 15 Phe Tyr Phe Ile Cys Ala Asp Ser Pro Arg Cys Arg Leu His Pro Phe 20 25 30 Trp Arg Arg Leu Ser Gln Ser Ser Gln Tyr Leu Arg Leu Pro Cys Leu 35 40 45 Cys His Cys Pro Leu Leu Trp Thr Trp Glu Leu Tyr Asn Thr Tyr Ser 50 55 60 Ala Val Trp Met Pro His His Thr Pro His Ser Cys Ser Ala Gly Gln 65 70 75 80 Tyr Leu His Ser Gly Ser Ser Tyr Ala Lys Ser His His Leu Trp Asp 85 90 95 Lys Asp Gln Thr Asp Pro Gly Pro Gly Gly Leu Cys Ile Val Tyr Lys 100 105 110

Ala Glu Ile Ile Leu 115

Page 3612

069269_0225_SL.TXT <210> 3233 <211> 944 <212> DNA <213> Felis catus <400> 3233 tcatttctgc tttggaaaca acacataaac tacttggtct catatctgtt ttattttgac 60 cccataaatg ataggattca gcatcggtgg aacaagcatg ctgacattgg ccaacagaat 120 gtggacatgt agtgggatgt gacgtccaaa gcgctgagtg agaaccaaga agatcccagg 180 cccataaaaa aggacaatga cacagacatg ggagccacat atgttgagag ctttgtggca 240 agcatctcgg gaagggatac ggtagatagc atggagtatc agagtatagg aaacaaaaat 300 gaggacaatg tctaggatca ctgtggacat taggacaaaa aatccatacc agatgtttat 360 acggatatca tcacaggcat acttggccaa accaatgtgt tcacagaatg tatgtggtag 420 gatgttattt ctgcaaaaag tgagtctctt cagaagaaat atcatgggga aaattgtaca 480 atgtgctctc aagaaaacag ccacaccaat tttccctatc agagaatgag tgagtatcat 540 ggtgtacctc agtgggtaac atattgcaat gtagcggtca aatgccataa tcagcaagat 600 gccagactca gaaatgaaga aggaatgctg gaagtagagc tgggcaatgc agctattaag 660 agagatctcc ctattattga accaaaaatt gccaatgcct tgggttctgt ggttgtggca 720 aagacaatgt caactccagc cagcatgcag aggaaaagat acataggctc atggaggctg 780 ctcttggtga ggataatata gatgagcaga ccatttccaa gaagagcaaa gacataggag 840 atgagtaagg gggtggaaat ccatatgtgt aggtcttctc ggcctggaat gcccagcaga 900 tagaagacta tatggttaac accagtgtga ttgaagctag ccat 944 <210> 3234 <211> 117 <212> PRT <213> Felis catus

<400> 3234 Met Ala Ser Phe Asn His Thr Gly Val Asn His Ile Val Phe Tyr Leu 1 5 10 15

Leu Gly Ile Pro Gly Arg Glu Asp Leu His Ile Trp Ile Ser Thr Pro 20 25 30

Page 3613

069269_0225_SL.TXT

Leu Leu Ile 35 Ser Tyr Val Phe Ala Leu Leu Gly Asn Gly Leu Leu Ile 40 45 Tyr Ile Ile Leu Thr Lys Ser Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Cys Met Leu Ala Gly Val Asp Ile Val Phe Ala Thr Thr Thr Glu 65 70 75 80 Pro Lys Ala Leu Ala Ile Phe Gly Ser Ile Ile Gly Arg Ser Leu Leu 85 90 95 Ile Ala Ala Leu Pro Ser Ser Thr Ser Ser Ile Pro Ser Ser Phe Leu 100 105 110

Ser Leu Ala Ser Cys 115 <210> 3235 <211> 964 <212> DNA <213> Felis catus <400> 3235

atggcaaccc ataaccacac tggtgccagc cactcacttt tcattctgcg gggcatccct 60 ggcctggaag accagcacat atggatttct cttcccttct ttatttccta cctggttgct 120 ctccttggga atagcctcct tgtcttcatc atcattactg aacgcagcct ccatgaaccc 180 atgtacctct ttctctgcat gctagctgtg gctgacctca tcctgtccac taccactgtg 240 cccaaagccc tggccatatt ctggtttcat gctggggaga tctcccttga tggctgcgtc 300 actcaaatct tcttcatcca tgccaccttc attgctgaat cagggattct gttggccatg 360 gcatttgacc gctatgtggc catctgtgac ccactgcgat atactacact gctcagtcat 420 gcagtaatca taaaggttgg tctggctgtg gtcctgagaa gcttctctgt gatactccca 480 gatgtgttcc tggtgaagag actgcctttc tgccatagca atgtgttacc acatacctac 540 tgtgagcaca tggctgttgc caagtttgct tgtgctgata ttcgtgtcaa tgtctggtat 600

Page 3614

069269_0225_SL.TXT

ggcttgtctg ttcttctctc tactgtaatg ccagatgcct tgctcatctt gttttcgtat 660 accctcatcc tcaatgcagt cttccacctc ccttcccgag gagctcggca aaaggctcta 720 ggcacatgtg gctcccacct tggggtcatt tccatgttct atttgtctgg catttttact 780 gtaattaccc agcggtttgg gcatcatgtt cccctccata ctcacattct gctggccaat 840 atctgcacat tagcccctcc catgctgaac cctatcattt atggggtcaa gaccaggcag 900 attcgagtgt gtgtggtcag tactctgtct tcacagtaga aacatgttga gtctgtgtga 960

ctga 964 <210> 3236 <211> 312 <212> PRT <213> Felis catus <400> 3236

Met Ala Thr His Asn His Thr Gly Ala Ser His Ser Leu Phe Ile Leu 1 5 10 15 Arg Gly Ile Pro Gly Leu Glu Asp Gln His Ile Trp Ile Ser Leu Pro 20 25 30 Phe Phe Ile Ser Tyr Leu Val Ala Leu Leu Gly Asn Ser Leu Leu Val 35 40 45 Phe Ile Ile Ile Thr Glu Arg Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Cys Met Leu Ala Val Ala Asp Leu Ile Leu Ser Thr Thr Thr Val 65 70 75 80 Pro Lys Ala Leu Ala Ile Phe Trp Phe His Ala Gly Glu Ile Ser Leu 85 90 95 Asp Gly Cys Val Thr Gln Ile Phe Phe Ile His Ala Thr Phe Ile Ala 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125

Page 3615

069269_0225_SL.TXT

Cys Asp 130 Pro Leu Arg Tyr Thr Thr Leu Leu Ser His Ala Val Ile Ile 135 140 Lys Val Gly Leu Ala Val Val Leu Arg Ser Phe Ser Val Ile Leu Pro 145 150 155 160 Asp Val Phe Leu Val Lys Arg Leu Pro Phe Cys His Ser Asn Val Leu 165 170 175 Pro His Thr Tyr Cys Glu His Met Ala Val Ala Lys Phe Ala Cys Ala 180 185 190 Asp Ile Arg Val Asn Val Trp Tyr Gly Leu Ser Val Leu Leu Ser Thr 195 200 205 Val Met Pro Asp Ala Leu Leu Ile Leu Phe Ser Tyr Thr Leu Ile Leu 210 215 220 Asn Ala Val Phe His Leu Pro Ser Arg Gly Ala Arg Gln Lys Ala Leu 225 230 235 240 Gly Thr Cys Gly Ser His Leu Gly Val Ile Ser Met Phe Tyr Leu Ser 245 250 255 Gly Ile Phe Thr Val Ile Thr Gln Arg Phe Gly His His Val Pro Leu 260 265 270 His Thr His Ile Leu Leu Ala Asn Ile Cys Thr Leu Ala Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Gly Val Lys Thr Arg Gln Ile Arg Val Cys 290 295 300 Val Val Ser Thr Leu Ser Ser Gln

305 310 <210> 3237 <211> 949 <212> DNA

Page 3616

069269_0225_SL.TXT <213> Felis catus

<400> 3237 atgttctcct gcaacaccag cacttctggt cattctacct tcctcctcac tggctttcca 60 ggcctggaag cctctcatta ttgggtttct atccccatca acctcatctg tgtgttttcc 120 atcctgggta acggtatcat tcttctcctg atctgcacgg atccagcctt acgtgaaccc 180 atgtacatct tcctgtccat gttggcagcc tctgatctag gcctctgtgc ctctactttt 240 cccaccatga tgtggctttt ctggctgggt gctcgtgagc tgccctttga tctctgtgca 300 gcgcagatgt tcttcatcca tgccttcacc tatgtggaat ctggtgtgct gctggccatg 360 gcctttgatc gttttgttgc catccgggaa cctctgcact atgccacaat tcttacccac 420 tcagccatgg ccaaggtggg ggctgccatc ctggtgaggg ctgtcctgct caacctccca 480 ggacccatcc tcctgcggcg tctgcttttc ccccagatca gtgtactttc tcactgctac 540 tgcctgcact gtgaccttgt gggattggcc tgctcagaca cccagatcaa cagcttggtt 600 ggcctggtct ccatcctctt ctcactgggc cttgattcct ccctcattgt gctctcatac 660 gccctgatcc tacaaacagt actgggcatt gcatcacctg gagaacagct caaggcactc 720 aacacatgtg tctcacacct ctgcgttgtt ctcatctttt atttgcccaa actggggctg 780 tctgtgttac acagagtaga gaagcacagc tatcctgctc tggcagtgct catggccaac 840 ctgcatttct tggtcccgcc tatcatgaac cccatagttt actgtatcaa gtctaagaag 900 atacgtcaga gcctcctaaa gcacttccag cataaaaggg ttgatgtct 949

<210> 3238 <211> 317 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (317)..(317) <223> Any amino acid <400> 3238

Met Phe Ser Cys Asn Thr Ser Thr Ser Gly His Ser Thr Phe Leu Leu 1 5 10 15

Page 3617

Thr Gly Phe Pro 20 Gly Leu Glu 069269_0225_SL.TXT Ala Ser His Tyr Trp Val 25 Ser 30 Ile Pro Ile Asn Leu Ile Cys Val Phe Ser Ile Leu Gly Asn Gly Ile Ile Leu 35 40 45 Leu Leu Ile Cys Thr Asp Pro Ala Leu Arg Glu Pro Met Tyr Ile Phe 50 55 60 Leu Ser Met Leu Ala Ala Ser Asp Leu Gly Leu Cys Ala Ser Thr Phe 65 70 75 80 Pro Thr Met Met Trp Leu Phe Trp Leu Gly Ala Arg Glu Leu Pro Phe 85 90 95 Asp Leu Cys Ala Ala Gln Met Phe Phe Ile His Ala Phe Thr Tyr Val 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Arg Glu Pro Leu His Tyr Ala Thr Ile Leu Thr His Ser Ala Met Ala 130 135 140 Lys Val Gly Ala Ala Ile Leu Val Arg Ala Val Leu Leu Asn Leu Pro 145 150 155 160 Gly Pro Ile Leu Leu Arg Arg Leu Leu Phe Pro Gln Ile Ser Val Leu 165 170 175 Ser His Cys Tyr Cys Leu His Cys Asp Leu Val Gly Leu Ala Cys Ser 180 185 190 Asp Thr Gln Ile Asn Ser Leu Val Gly Leu Val Ser Ile Leu Phe Ser 195 200 205 Leu Gly Leu Asp Ser Ser Leu Ile Val Leu Ser Tyr Ala Leu Ile Leu 210 215 220

Page 3618

Gln 225 Thr Val Leu Gly Ile 230 Ala 069269_0225_SL.TXT Ser Pro Gly Glu Gln Leu 235 Lys Ala Leu 240 Asn Thr Cys Val Ser His Leu Cys Val Val Leu Ile Phe Tyr Leu Pro 245 250 255 Lys Leu Gly Leu Ser Val Leu His Arg Val Glu Lys His Ser Tyr Pro 260 265 270 Ala Leu Ala Val Leu Met Ala Asn Leu His Phe Leu Val Pro Pro Ile 275 280 285 Met Asn Pro Ile Val Tyr Cys Ile Lys Ser Lys Lys Ile Arg Gln Ser 290 295 300 Leu Leu Lys His Phe Gln His Lys Arg Val Asp Val Xaa 305 310 315

<210> 3239 <211> 948 <212> DNA <213> Felis catus <400> 3239

ttaagactga acaatgcccc gcttcagcag tcggagggcc ccatcccgga tctgcttggt 60 cttcatgcca tagatgatgg ggttgagcat gggtggtaca acaaggtaga ggtcagccaa 120 gaggatatgg atgtgccggg gcacatgctg gccaaagcgc tgagtgtaga atgagaagag 180 ccctggtgta tagaagagaa ggatgacacc caggtgggag ccacaagtgc caaaggtctt 240 agctcttgcc tctttggagg agaggcctaa cacagcccgg aggattagtg tataggagac 300 agtgatgcag atggaatctg tgcccacaac tagcgtggca gcagtaatgc catagatgtt 360 gtttggccgt gtacccccac aagccagctt taccacagcc atgtgctcac agtaggagtg 420 ggccaccact cggctacagt agctcagcct tgccaataag catgtgagtg gggtcatgag 480 gcccaagcca cgaaacacag cagcagctgc cagcttgccc acagcctctg ggggcaacaa 540 tgacccatag tgcagtggcc ggcagatggc caagtagcgg tcaaaggcca ttgctaacag 600 gataccagat tcaacagctg aaaagccatg gataaagaac atctgagtag cacaggcccc 660

Page 3619

069269_0225_SL.TXT aaagtcaatc tcagtagcat ttgtccaaaa aagtgcaagg agtttgggca cagtagaagt gcagagcacc aggtcaatga tggacagcat gcataggaac aggtacatgg gctggtgcag tgcaggctct gatcgcacca ccagcagcac tgccatgttg ccaagcactg ccagggcata catggagcag aagggaaatg caatccaaaa gtgggatgcc tccaggccag gaattcccat gagcagaaaa gagtttgggt tctgatggct gtggtttgtg aaatgcat

720

780

840

900

948 <210> 3240 <211> 315 <212> PRT <213> Felis catus <400> 3240

Met His Phe Thr 1 Asn 5 His Ser His Gln Asn Pro Asn Ser Phe Leu Leu 10 15 Met Gly Ile Pro Gly Leu Glu Ala Ser His Phe Trp Ile Ala Phe Pro 20 25 30 Phe Cys Ser Met Tyr Ala Leu Ala Val Leu Gly Asn Met Ala Val Leu 35 40 45 Leu Val Val Arg Ser Glu Pro Ala Leu His Gln Pro Met Tyr Leu Phe 50 55 60 Leu Cys Met Leu Ser Ile Ile Asp Leu Val Leu Cys Thr Ser Thr Val 65 70 75 80 Pro Lys Leu Leu Ala Leu Phe Trp Thr Asn Ala Thr Glu Ile Asp Phe 85 90 95 Gly Ala Cys Ala Thr Gln Met Phe Phe Ile His Gly Phe Ser Ala Val 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Leu Ala Ile 115 120 125 Cys Arg Pro Leu His Tyr Gly Ser Leu Leu Pro Pro Glu Ala Val Gly 130 135 140

Page 3620

069269_0225_SL.TXT

Lys Leu Ala Ala Ala Ala Val Phe Arg Gly Leu Gly Leu Met Thr Pro 145 150 155 160 Leu Thr Cys Leu Leu Ala Arg Leu Ser Tyr Cys Ser Arg Val Val Ala 165 170 175 His Ser Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys Gly Gly 180 185 190 Thr Arg Pro Asn Asn Ile Tyr Gly Ile Thr Ala Ala Thr Leu Val Val 195 200 205 Gly Thr Asp Ser Ile Cys Ile Thr Val Ser Tyr Thr Leu Ile Leu Arg 210 215 220 Ala Val Leu Gly Leu Ser Ser Lys Glu Ala Arg Ala Lys Thr Phe Gly 225 230 235 240 Thr Cys Gly Ser His Leu Gly Val Ile Leu Leu Phe Tyr Thr Pro Gly 245 250 255 Leu Phe Ser Phe Tyr Thr Gln Arg Phe Gly Gln His Val Pro Arg His 260 265 270 Ile His Ile Leu Leu Ala Asp Leu Tyr Leu Val Val Pro Pro Met Leu 275 280 285 Asn Pro Ile Ile Tyr Gly Met Lys Thr Lys Gln Ile Arg Asp Gly Ala 290 295 300 Leu Arg Leu Leu Lys Arg Gly Ile Val Gln Ser 305 310 315

<210> 3241 <211> 942 <212> DNA <213> Felis catus <400> 3241 tcagcctcca acatcacctc aacccatccg tcagtcttcg tgttgatggg gattccaggc

Page 3621

069269_0225_SL.TXT

ctgcagcacc tacataattg gatctccatt cccttctgct cagcttatac tctagccttg 120 ctaggcaact gcaccctcct cttcatcatc cagactgatg cagccctcca cgagcccatg 180 tacctctttc tggccatgct ggcagtcatt gatctggttc tctcttctac aacacttccc 240 aaaatgctag ctattttttg gttcagagat cgggagatca acttctatgc ctgtctggtc 300 cagatgttct ttctccactc cttctctatc atggagtcag caatgcttct ggccatggcc 360 tttgaccgct atgtggctat ctgcaagcca ctgcactaca ctacagtcct gactgggtcc 420 cttatcacta ggattggcat ggctgctgtg actcgggctg tgacactaat gactccactc 480 ccctttctgc tcagacgttt ccactactgc cgaggccccc taattgccca ctgctactgt 540 gagcacatgg ctgtggtaag gcttgcctgt ggggacactc gcttcaacaa tatctatggc 600 attgctgtgg ccatgtttat agtggtgttg gacctgctct ttgttatcct gtcttatatc 660 ttcatccttc aagcagttct acggctctcc tctcaggagg cccgttacaa ggcctttggg 720 acatgtgtgt ctcacatagg tgctatctta gctttctaca cacctgtggt catctcctca 780 gtcatgcacc gtgtggctcg ccaggctgcc cctcatgtcc acatactctt tgctaatttc 840 tatctgctct tcccacccat gattaatccc atcatctatg gtgtcaagac caagcagatt 900 cgcaagcgag ccttaggact attctcaaga aaggatgtat aa 942

<210> 3242 <211> 313 <212> PRT <213> Felis catus

<400> 3242 Thr Ser Thr His Pro Ser Val Phe Val Leu Met Ser 1 Ala Ser Asn Ile 5 10 15 Gly Ile Pro Gly Leu Gln His Leu His Asn Trp Ile Ser Ile Pro Phe 20 25 30 Cys Ser Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu Phe 35 40 45

Ile Ile Gln Thr Asp Ala Ala Leu 50 55

His Glu

Pro Met Tyr Leu Phe Leu 60

Page 3622

069269_0225_SL.TXT

Ala Met 65 Leu Ala Val Ile 70 Asp Leu Val Leu Ser Ser Thr Thr Leu Pro 75 80 Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile Asn Phe Tyr 85 90 95 Ala Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser Ile Met Glu 100 105 110 Ser Ala Met Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Lys Pro Leu His Tyr Thr Thr Val Leu Thr Gly Ser Leu Ile Thr Arg 130 135 140 Ile Gly Met Ala Ala Val Thr Arg Ala Val Thr Leu Met Thr Pro Leu 145 150 155 160 Pro Phe Leu Leu Arg Arg Phe His Tyr Cys Arg Gly Pro Leu Ile Ala 165 170 175 His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Cys Gly Asp 180 185 190 Thr Arg Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met Phe Ile Val 195 200 205 Val Leu Asp Leu Leu Phe Val Ile Leu Ser Tyr Ile Phe Ile Leu Gln 210 215 220 Ala Val Leu Arg Leu Ser Ser Gln Glu Ala Arg Tyr Lys Ala Phe Gly 225 230 235 240 Thr Cys Val Ser His Ile Gly Ala Ile Leu Ala Phe Tyr Thr Pro Val 245 250 255 Val Ile Ser Ser Val Met His Arg Val Ala Arg Gln Ala Ala Pro His 260 265 270

Page 3623

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Val His Ile Leu Phe Ala Asn Phe Tyr Leu Leu Phe Pro Pro Met Ile 275 280 285 Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Lys Arg Ala 290 295 300 Leu Gly Leu Phe Ser Arg Lys Asp Val

305 310 <210> 3243 <211> 945 <212> DNA <213> Felis catus <400> 3243

atgacagcct ccaatattac cacaacccat ccaacttcct tcctgctggt aggaattcca 60 ggtttggaac acctgcatgt ctggatctct attccattct ccttcgccta tactctggcc 120 ctgctaggca actgcaccct cctcttcatc atccagactg atgcagccct ccacgagccc 180 atgtacctct ttctggccat gctggcagtc attgatctgg ttctctcttc tacaacactt 240 cccaaaatgc tagctatttt ttggttcaga gatcgggaga tcaacttcta tgcctgtctg 300 gtccagatgt tctttctcca ctccttctct atcatggagt cagcaatgct tctggccatg 360 gcctttgacc gctatgtggc tatctgcaag ccactgcact acaccacagt cctgactggg 420 tcccttatca ctaggattgg catggctgct gtgactcggg ctgtgacact aatgactcca 480 ctcccctttc tgctcagacg tttccactac tgccgaggcc ccctaattgc ccactgctac 540 tgtgagcaca tggctgtggt aaggcttgcc tgtggggaca ctcgcttcaa caatatctat 600 ggcattgctg tggccatgtt tatagtggtg ttggacctgc tctttgttat cctgtcttat 660 atcttcatcc ttcgagcagt tctacggctc tcctctcagg aggcccgtta caaggccttt 720 gggacatgtg tgtctcacat aggtgccatc ttgtccacct acacacctgt ggtcatctcc 780 tcagtcatgc accgtgtggc tcgacaggct gcccctcatg tccacatact ccttgctatt 840 ttctatcttc tttttccacc catgatcaac cccatcattt atggcatcaa gaccaaacag 900 attcgtgatc atgtgctcag tctatttcaa agaaagaatg tgtag 945

Page 3624

069269_0225_SL.TXT <210> 3244 <211> 314 <212> PRT <213> Felis catus

<400> 3244 Met 1 Thr Ala Ser Asn Ile 5 Thr Thr Thr His 10 Pro Thr Ser Phe Leu 15 Leu Val Gly Ile Pro Gly Leu Glu His Leu His Val Trp Ile Ser Ile Pro 20 25 30 Phe Ser Phe Ala Tyr Thr Leu Ala Leu Leu Gly Asn Cys Thr Leu Leu 35 40 45 Phe Ile Ile Gln Thr Asp Ala Ala Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Ala Val Ile Asp Leu Val Leu Ser Ser Thr Thr Leu 65 70 75 80 Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Asp Arg Glu Ile Asn Phe 85 90 95 Tyr Ala Cys Leu Val Gln Met Phe Phe Leu His Ser Phe Ser Ile Met 100 105 110 Glu Ser Ala Met Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Lys Pro Leu His Tyr Thr Thr Val Leu Thr Gly Ser Leu Ile Thr 130 135 140 Arg Ile Gly Met Ala Ala Val Thr Arg Ala Val Thr Leu Met Thr Pro 145 150 155 160 Leu Pro Phe Leu Leu Arg Arg Phe His Tyr Cys Arg Gly Pro Leu Ile 165 170 175 Ala His Cys Tyr Cys Glu His Met Ala Val Val Arg Leu Ala Cys Gly

Page 3625

180

069269_0225_SL.TXT 185 190

Asp Thr Arg 195 Phe Asn Asn Ile Tyr Gly Ile Ala Val Ala Met Phe Ile 200 205 Val Val Leu Asp Leu Leu Phe Val Ile Leu Ser Tyr Ile Phe Ile Leu 210 215 220 Arg Ala Val Leu Arg Leu Ser Ser Gln Glu Ala Arg Tyr Lys Ala Phe 225 230 235 240 Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ser Thr Tyr Thr Pro 245 250 255 Val Val Ile Ser Ser Val Met His Arg Val Ala Arg Gln Ala Ala Pro 260 265 270 His Val His Ile Leu Leu Ala Ile Phe Tyr Leu Leu Phe Pro Pro Met 275 280 285 Ile Asn Pro Ile Ile Tyr Gly Ile Lys Thr Lys Gln Ile Arg Asp His 290 295 300 Val Leu Ser Leu Phe Gln Arg Lys Asn Val 305 310

<210> 3245 <211> 955 <212> DNA <213> Felis catus <400> 3245 tcacttgggt tgagactctg ccttaaggat gtggagaaat ctttctcgaa tctgtttggt acggacagca tagacaactg ggttgaggat gggtgggatg aggaggtaaa agttgggcca aaaggatatg gatatgggga ggcacatcat gtccaaagcg gtgagtgaga gaagaaacag caatggggat atagaagaca agaatggcac aaatatgaga actacatgtc cctagggttt taagcctagc ctcaggggtg ctcaatccca ttacagcctt gaaaatcatc acataggaga cagtgatggc taatgaatcc aagatcaata ccaggaagcc aattcccatt ccataaaagt

120

180

240

300

360

Page 3626

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tgttgactgt tgtgtcacca catgccatgg tgactacagc catgtgctca caataggaat 420 gggcaatgat ttgggtccgg taaaggggca gcctcaggcg aatcatcaga ggtaggggtc 480 caatgtagag tactccacgg aggagggcag ccaggcccaa acgacccacc actgcatgag 540 tgagcactga ggtgtggtgt aatgggtcac aaatagcgac atagcgatca aaagccatgg 600 caaggaagat gcctgactca acagtggcaa agcagtggat gaagaacatc tgagtcaagc 660 aggcatccag gtcaatgttg cgggcaccaa accagaagat agctagcagt ttgggcatgg 720 tagaggttga caggaccaag tcaatgacag ccaacatgca taggaagaag tacatgggtt 780 ggtgcaggct gcgttccatc tttatcaccg ccaggatggt cacattcccc accacagcca 840 ccaggtacat agagctgaag gggatagaaa gccagatgtg cagggactcc agccctggaa 900 ttccagtaag ccagaaagaa ctaggcacca agcaggcatt gttagatatg aacat 955

<210> 3246 <211> 310 <212> PRT <213> Felis catus <400> 3246

Met 1 Phe Ile Ser Asn Asn Ala Cys 5 Leu Val Pro Ser Ser Phe Trp Leu 10 15 Thr Gly Ile Pro Gly Leu Glu Ser Leu His Ile Trp Leu Ser Ile Pro 20 25 30 Phe Ser Ser Met Tyr Leu Val Ala Val Val Gly Asn Val Thr Ile Leu 35 40 45 Ala Val Ile Lys Met Glu Arg Ser Leu His Gln Pro Met Tyr Phe Phe 50 55 60 Leu Cys Met Leu Ala Val Ile Asp Leu Val Leu Ser Thr Ser Thr Met 65 70 75 80 Pro Lys Leu Leu Ala Ile Phe Trp Phe Gly Ala Arg Asn Ile Asp Leu 85 90 95

Page 3627

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Asp Ala Cys Leu Thr Gln Met Phe Phe Ile His Cys Phe Ala Thr Val 100 105 110 Glu Ser Gly Ile Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu His His Thr Ser Val Leu Thr His Ala Val Val Gly 130 135 140 Arg Leu Gly Leu Ala Ala Leu Leu Arg Gly Val Leu Tyr Ile Gly Pro 145 150 155 160 Leu Pro Leu Met Ile Arg Leu Arg Leu Pro Leu Tyr Arg Thr Gln Ile 165 170 175 Ile Ala His Ser Tyr Cys Glu His Met Ala Val Val Thr Met Ala Cys 180 185 190 Gly Asp Thr Thr Val Asn Asn Phe Tyr Gly Met Gly Ile Gly Phe Leu 195 200 205 Val Leu Ile Leu Asp Ser Leu Ala Ile Thr Val Ser Tyr Val Met Ile 210 215 220 Phe Lys Ala Val Met Gly Leu Ser Thr Pro Glu Ala Arg Leu Lys Thr 225 230 235 240 Leu Gly Thr Cys Ser Ser His Ile Cys Ala Ile Leu Val Phe Tyr Ile 245 250 255 Pro Ile Ala Val Ser Ser Leu Thr His Arg Phe Gly His Asp Val Pro 260 265 270 Pro His Ile His Ile Leu Leu Ala Gln Leu Leu Pro Pro His Pro Thr 275 280 285 His Pro Gln Pro Ser Cys Leu Cys Cys Pro Tyr Gln Thr Asp Ser Arg 290 295 300

Page 3628

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Lys Ile Ser Pro His Pro 305 310 <210> 3247 <211> 954 <212> DNA <213> Felis catus <400> 3247

atgctcactt ttcaaaattc ctgctcagta cccagctcct tccagcttgc cggcatccca 60 gggctggagt ccctgcatct ctggctttcc atcccctttg gctccatgta cctggttgcc 120 gtggtgggga acatcaccat tctggctgtg gtaaaggtgg agaatagcct gcaccagccc 180 atgtacttct tcctttgtat gttggcggtt gttgacctgg ttctatccac ttctactatg 240 cccaaactgc tgggaatctt ctggtttggt gctggtgata ttggcctgga tgcctgcttg 300 gcccaaatgt tcctcatcca ctgctttgcc acagttgagt caggcatctt ccttgacatg 360 gctttggacc gctacgtagc catttgcaac ccgctacatc ataccacagt gctcactcat 420 gctatggtgg gacggttggg gctggctgcc ctctttcggg gggtactcta cattggacct 480 ctgcctttga tgatccgcct atggctgccc ctttacaagg ctcatgtcat ctcacactct 540 tactgtgagc acatggctgt ggtcaccttg gcatgtggtg acagcagggt caacaatgtc 600 tatgggctaa gcattggttt tttggtccta atcttggatt ccatggctat tgctgtctct 660 tatgtgatga ttttccgggc cgtgatgggg ctagccacac ctgaagcccg acttaaaacc 720 ctggggacat gtggttctca catctgtgcc attctgatct tttatgttcc tattgtggtt 780 tcttctctca ttcaccgatt tggtcaccag gtacctcctc caatccacac tttactggct 840 aacttctacc tcctcattcc tccaatcctt aatcccattg tttacgctgt ccgcaccaag 900 cagatccggg agcggcttct ccaaatgctg aagacagaaa ctaagttcaa gtga 954

<210> 3248 <211> 317 <212> PRT <213> Felis catus <400> 3248

Met Leu Thr Phe Gln Asn Ser Cys Ser Val Pro Ser Ser Phe Gln Leu 1 5 10 15

Page 3629

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Ala Gly Ile Pro Gly Leu Glu Ser Leu His Leu Trp Leu Ser 30 Ile Pro 20 25 Phe Gly Ser Met Tyr Leu Val Ala Val Val Gly Asn Ile Thr Ile Leu 35 40 45 Ala Val Val Lys Val Glu Asn Ser Leu His Gln Pro Met Tyr Phe Phe 50 55 60 Leu Cys Met Leu Ala Val Val Asp Leu Val Leu Ser Thr Ser Thr Met 65 70 75 80 Pro Lys Leu Leu Gly Ile Phe Trp Phe Gly Ala Gly Asp Ile Gly Leu 85 90 95 Asp Ala Cys Leu Ala Gln Met Phe Leu Ile His Cys Phe Ala Thr Val 100 105 110 Glu Ser Gly Ile Phe Leu Asp Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu His His Thr Thr Val Leu Thr His Ala Met Val Gly 130 135 140 Arg Leu Gly Leu Ala Ala Leu Phe Arg Gly Val Leu Tyr Ile Gly Pro 145 150 155 160 Leu Pro Leu Met Ile Arg Leu Trp Leu Pro Leu Tyr Lys Ala His Val 165 170 175 Ile Ser His Ser Tyr Cys Glu His Met Ala Val Val Thr Leu Ala Cys 180 185 190 Gly Asp Ser Arg Val Asn Asn Val Tyr Gly Leu Ser Ile Gly Phe Leu 195 200 205 Val Leu Ile Leu Asp Ser Met Ala Ile Ala Val Ser Tyr Val Met Ile 210 215 220

Page 3630

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Phe 225 Arg Ala Val Met Gly Leu Ala Thr Pro Glu Ala Arg Leu Lys Thr 230 235 240 Leu Gly Thr Cys Gly Ser His Ile Cys Ala Ile Leu Ile Phe Tyr Val 245 250 255 Pro Ile Val Val Ser Ser Leu Ile His Arg Phe Gly His Gln Val Pro 260 265 270 Pro Pro Ile His Thr Leu Leu Ala Asn Phe Tyr Leu Leu Ile Pro Pro 275 280 285 Ile Leu Asn Pro Ile Val Tyr Ala Val Arg Thr Lys Gln Ile Arg Glu 290 295 300 Arg Leu Leu Gln Met Leu Lys Thr Glu Thr Lys Phe Lys 305 310 315

<210> 3249 <211> 975 <212> DNA <213> Felis catus <400> 3249

atgctgggga taccctataa ccacacagtg gaaactcctg ccaccttctt ccttgtgggt 60 atcccaggtt tgccatcttc ccatctttgg ctggctattt cactgggtgc catgtatacc 120 atatccctgt taggaaacac cctcatcatg accgtaatct ggatggattt cactctacga 180 gagcccatgt attgcttcct gtatgtactg actgctgtgg atattgttat ggtctcctct 240 gtggtaccaa agatggtgag catattctct tcaggagatg gctccatcag ctttaatgct 300 tgtttcactc agatgtattt tgtccatgta gccacatctg tggagacagg gctattgctg 360 gccatggctt ttgaccgcta tatagccatc tgtaagcccc tgcactacaa gaggattctc 420 acacctcaac tgatgctggt aatgagtgtg gccatcacca tcagggctgt catattcatg 480 actccactga gttggatggt aagtcatctg cctttctgtg gctccaatgt ggttctccat 540 tcctactgtg agcacatagc cgtggccaag ttggcatgtg ctgaccccat gcccagtagt 600 ctctacagtg tgattggctc ctccattatt gtgggctctg atgtggcctt catttctgcc 660

Page 3631

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tcctataacc tgattctcca ggcagtatgt ggtctctctt caaagaatgc tcaattgaaa 720 gcattaagca catgtggctc ccacatgggg gttatggctc tgtactacct acctgggatg 780 gcatccatct atgtggcctg gctagggaag gatacagtgc ctctgtacat ccaagtactg 840 ttagctgatt tgtatttgat catcccacct acctttaacc ccatcattta tggcctgagg 900 accaaacaaa tgcggaagcg aatatggagc ttgctgatac actgcctctt tgacctctcc 960 aaactgggtt cataa 975

<210> 3250 <211> 324 <212> PRT <213> Felis catus <400> 3250

Met 1 Leu Gly Ile Pro 5 Tyr Asn His Thr Val Glu Thr Pro Ala Thr Phe 10 15 Phe Leu Val Gly Ile Pro Gly Leu Pro Ser Ser His Leu Trp Leu Ala 20 25 30 Ile Ser Leu Gly Ala Met Tyr Thr Ile Ser Leu Leu Gly Asn Thr Leu 35 40 45 Ile Met Thr Val Ile Trp Met Asp Phe Thr Leu Arg Glu Pro Met Tyr 50 55 60 Cys Phe Leu Tyr Val Leu Thr Ala Val Asp Ile Val Met Val Ser Ser 65 70 75 80 Val Val Pro Lys Met Val Ser Ile Phe Ser Ser Gly Asp Gly Ser Ile 85 90 95 Ser Phe Asn Ala Cys Phe Thr Gln Met Tyr Phe Val His Val Ala Thr 100 105 110 Ser Val Glu Thr Gly Leu Leu Leu Ala Met Ala Phe Asp Arg Tyr Ile 115 120 125

Page 3632

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Ala Ile Cys Lys Pro Leu His Tyr Lys Arg Ile Leu Thr Pro Gln Leu 130 135 140 Met Leu Val Met Ser Val Ala Ile Thr Ile Arg Ala Val Ile Phe Met 145 150 155 160 Thr Pro Leu Ser Trp Met Val Ser His Leu Pro Phe Cys Gly Ser Asn 165 170 175 Val Val Leu His Ser Tyr Cys Glu His Ile Ala Val Ala Lys Leu Ala 180 185 190 Cys Ala Asp Pro Met Pro Ser Ser Leu Tyr Ser Val Ile Gly Ser Ser 195 200 205 Ile Ile Val Gly Ser Asp Val Ala Phe Ile Ser Ala Ser Tyr Asn Leu 210 215 220 Ile Leu Gln Ala Val Cys Gly Leu Ser Ser Lys Asn Ala Gln Leu Lys 225 230 235 240 Ala Leu Ser Thr Cys Gly Ser His Met Gly Val Met Ala Leu Tyr Tyr 245 250 255 Leu Pro Gly Met Ala Ser Ile Tyr Val Ala Trp Leu Gly Lys Asp Thr 260 265 270 Val Pro Leu Tyr Ile Gln Val Leu Leu Ala Asp Leu Tyr Leu Ile Ile 275 280 285 Pro Pro Thr Phe Asn Pro Ile Ile Tyr Gly Leu Arg Thr Lys Gln Met 290 295 300 Arg Lys Arg Ile Trp Ser Leu Leu Ile His Cys Leu Phe Asp Leu Ser 305 310 315 320

Lys Leu Gly Ser

Page 3633

069269_0225_SL.TXT catggccact tggcctgggg ggccaccctg gcccatgtac catgcccaag tctggcccag tatggctttt agggcctact ccctctgccc cttctgtctg atatggactc ctacattctt tttcaatacc gctctcagtg tatctatttg gatccgttca ccaaatggaa cctgacatac ggaaacctgg ctcttcctgg atggccagcc atgttcctta gaccgctttg gtggccaaga ttcatcctga caccaagata ttcattatcc atcctgaaga tgcctctccc gtgcacaggc ctactaccac cgggtcctcc <210> 3251 <211> 956 <212> DNA <213> Felis catus <400> 3251 tggttcctgt tgggaatccc tgtatgccat gtctgcacga cttctgtcac tcaatgtttg ttctgctggc ctgtgctcac ttttcttctt tcacacactc tcaatgtagt ttggcttctc cactcaaggc ccctcattgg ttatggctaa aaaccaagga <210> 3252 <211> 314 <212> PRT <213> Felis catus <400> 3252

Met Ala Thr Pro Asn Gly Thr Leu Val 1 5 ctctggtcca tccagcatac ttcctgctgg 60 acttttggct ggctttcccc ctgtgcttta 120 ccattgtcct catcatccgt gtggaaaggc 180 ccatgctttc cactattgac ctagtcctgt 240 tcttcctgac aggcatccag gagataggat 300 tccatgctct gtcagccatg gagtcagctg 360 tggccatctg tcatccactg cggcatgctt 420 ttggactagc tgccctgacc aggggatttg 480 agcggttgtc atactgccaa acacatatgg 540 ttatgaagtt gtcctgttct gacaccaggg 600 tctcagtcat gggtgtggac tccctcttca 660 ctgtgttgga gctggcttct cagggggcag 720 atctctgtgc tgtcctggtc ttctatgtgc 780 tggggggccc tacctccctg ctccatgtga 840 ctgtggtcaa ccctgttgtc tatggagcca 900 atatgttctc acagggtggc aggtga 956

Val Gly Ile Pro Gly Leu Gly Pro Asp 20 25

His Pro Ala Tyr Phe Leu Leu 10 15 Ile His Phe Trp Leu Ala Phe 30

Page 3634

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Pro Leu Cys 35 Phe Met Tyr Ala Met Ala Thr Leu Gly Asn Leu Ala Ile 40 45 Val Leu Ile Ile Arg Val Glu Arg Arg Leu His Glu Pro Met Tyr Leu 50 55 60 Phe Leu Ala Met Leu Ser Thr Ile Asp Leu Val Leu Ser Ser Val Thr 65 70 75 80 Met Pro Lys Met Ala Ser Leu Phe Leu Thr Gly Ile Gln Glu Ile Gly 85 90 95 Phe Asn Val Cys Leu Ala Gln Met Phe Leu Ile His Ala Leu Ser Ala 100 105 110 Met Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala 115 120 125 Ile Cys His Pro Leu Arg His Ala Ser Val Leu Thr Gly Pro Thr Val 130 135 140 Ala Lys Ile Gly Leu Ala Ala Leu Thr Arg Gly Phe Val Phe Phe Phe 145 150 155 160 Pro Leu Pro Phe Ile Leu Lys Arg Leu Ser Tyr Cys Gln Thr His Met 165 170 175 Val Thr His Ser Phe Cys Leu His Gln Asp Ile Met Lys Leu Ser Cys 180 185 190 Ser Asp Thr Arg Val Asn Val Val Tyr Gly Leu Phe Ile Ile Leu Ser 195 200 205 Val Met Gly Val Asp Ser Leu Phe Ile Gly Phe Ser Tyr Ile Leu Ile 210 215 220 Leu Lys Thr Val Leu Glu Leu Ala Ser Gln Gly Ala Ala Leu Lys Ala 225 230 235 240

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Phe Asn Thr Cys Leu Ser 245 His Leu Cys Ala Val Leu Val Phe Tyr Val 250 255 Pro Leu Ile Gly Leu Ser Val Val His Arg Leu Gly Gly Pro Thr Ser 260 265 270 Leu Leu His Val Ile Met Ala Asn Ile Tyr Leu Leu Leu Pro Pro Val 275 280 285 Val Asn Pro Val Val Tyr Gly Ala Lys Thr Lys Glu Ile Arg Ser Arg 290 295 300 Val Leu His Met Phe Ser Gln Gly Gly Arg 305 310

<210> 3253 <211> 954 <212> DNA <213> Felis catus <400> 3253

atggtggaca ccaatggcag tgaatctagt gccacatatt tcattctaat aggccttcca 60 ggcttggaaa aagctcagtt ctggttggcc ttcccgttat gctccctcta ccttattgct 120 gtgctaggta acctgacagt catctgcatt gtgcggactg agcacagact acatgaaccc 180 atgtatattt ttctttgcat gctttctggc cttgacatac ttatctctac ttcatctatg 240 cccagaatga tggccatctt ctggttcaat tccactacca tccagtttga tgcttgtctt 300 ctacagatgt ttgccatcca ctccttatct ggcatggagt ccactgtact gctggccatg 360 gcctttgacc gctatgtggc catttgtcac ccactacgcc atgccactgt gctaacattg 420 cctcgtgtta ccaagattgg cgtggctgct gtggtacggg gtacttcact tatggcaccc 480 ctgcctatct tcatcaaacg gctgcctttc tgccgctcca acattctttc ccattcctac 540 tgcctacatc aagatgtcat gaagctggct tgtgctgaca tccgtgtcaa tatcatctat 600 ggcctcattg tcatcatctc tgccattggc ctggactcac ttctcatctc cttgtcatat 660 ctgcttatcc tcaagactgt gttgggcttg acacgtgaag cccaggcaaa ggcatttggc 720 acttgtgtct ctcatgtgtg tgctgttttc atattctatg tacctttcat tgggttatct 780

Page 3636

069269_0225_SL.TXT atggtgcacc gctttgggaa gcggcatgac tccctcctgc ccatcattat ggccaacacc tacttgcttg ttcctcctgt gctcaaccct attgtttatg gagtgaagac aaaggagatc cggcagcgta tccttcgtct tttccatgtg accacccata cttcagatcc ctag

840

900

954 <210> 3254 <211> 317 <212> PRT <213> Felis catus

<400> 3254 Gly Ser Glu Ser Ser Ala Thr Tyr Phe Ile Leu Met Val 1 Asp Thr Asn 5 10 15 Ile Gly Leu Pro Gly Leu Glu Lys Ala Gln Phe Trp Leu Ala Phe Pro 20 25 30 Leu Cys Ser Leu Tyr Leu Ile Ala Val Leu Gly Asn Leu Thr Val Ile 35 40 45 Cys Ile Val Arg Thr Glu His Arg Leu His Glu Pro Met Tyr Ile Phe 50 55 60 Leu Cys Met Leu Ser Gly Leu Asp Ile Leu Ile Ser Thr Ser Ser Met 65 70 75 80 Pro Arg Met Met Ala Ile Phe Trp Phe Asn Ser Thr Thr Ile Gln Phe 85 90 95 Asp Ala Cys Leu Leu Gln Met Phe Ala Ile His Ser Leu Ser Gly Met 100 105 110 Glu Ser Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg His Ala Thr Val Leu Thr Leu Pro Arg Val Thr 130 135 140 Lys Ile Gly Val Ala Ala Val Val Arg Gly Thr Ser Leu Met Ala Pro 145 150 155 160

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Leu Pro Ile Phe Ile Lys Arg Leu Pro Phe Cys Arg Ser Asn Ile Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ala 180 185 190 Asp Ile Arg Val Asn Ile Ile Tyr Gly Leu Ile Val Ile Ile Ser Ala 195 200 205 Ile Gly Leu Asp Ser Leu Leu Ile Ser Leu Ser Tyr Leu Leu Ile Leu 210 215 220 Lys Thr Val Leu Gly Leu Thr Arg Glu Ala Gln Ala Lys Ala Phe Gly 225 230 235 240 Thr Cys Val Ser His Val Cys Ala Val Phe Ile Phe Tyr Val Pro Phe 245 250 255 Ile Gly Leu Ser Met Val His Arg Phe Gly Lys Arg His Asp Ser Leu 260 265 270 Leu Pro Ile Ile Met Ala Asn Thr Tyr Leu Leu Val Pro Pro Val Leu 275 280 285 Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Glu Ile Arg Gln Arg Ile 290 295 300 Leu Arg Leu Phe His Val Thr Thr His Thr Ser Asp Pro 305 310 315

<210> 3255 <211> 963 <212> DNA <213> Felis catus <400> 3255 tcagtcttgg ccttttctct ttagcatcct aagcatggct tccctgatgg gcttggattt cacactgtag atgatggggt tgagcacagg gggtaccacc aggtatacat aggcaaccag

120

Page 3638

069269_0225_SL.TXT ggcatgtgca atgggggaca agtgcctccc aaaacggtgg atcatggacg tggtaatgcc tggaatgaaa aagacaaaga cagccaggat atgggaaaca caggtgttga aggctcggat gcgctccctg ggagatgcca gtcccaggat tgtgtgtagg atgagaatat aggataggat gatgagcaga gagtctatgc ctccagtgga caataccaca tagagcccat agaagatgtt tatggtgatg tcagcacagg ctcttctcat cacatcagga tgaaaacaga acgagtggga caaaaggatt ttgttagggc agaagttcaa gcgtttaagc aggaaaggca ctgggaagag agacagggca gcacgggcca caatggccat cccaatcctg atgatgacat tattggtgag gacagttgca tagcgaagag ggttcgagat ggccacaaag cggtcaaatg acatggccag gagcactgac gactccacca cagagaagga atggagaaag aacatctgga ccaggcaggc attgaagcct atgagcctgt ggccaaacca gagcacagcc aaggtggtgg gcagtgtgga cagggtgagg cccacgtcgg tgagggccag catggacaag aaatagtaca tgggctggtg caggctggga gtcttcctca cagccaagag gatcaggcag tttccagtga gggccatagt gtacatggag gagaagggga tagagatcca tccatgaaca gcctcatgcc ctgggatgcc aatcatcagg aaggcatgtg gctggaagaa ggagatgttg acataggtct gggaagggag cat <210> 3256 <211> 320 <212> PRT <213> Felis catus <400> 3256

180

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Met 1 Leu Pro Ser Gln 5 Thr Tyr Val Asn Ile Ser Phe Phe Gln 10 Pro 15 His Ala Phe Leu Met Ile Gly Ile Pro Gly His Glu Ala Val His Gly Trp 20 25 30 Ile Ser Ile Pro Phe Ser Ser Met Tyr Thr Met Ala Leu Thr Gly Asn 35 40 45 Cys Leu Ile Leu Leu Ala Val Arg Lys Thr Pro Ser Leu His Gln Pro 50 55 60

Page 3639

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Met Tyr 65 Tyr Phe Leu Ser 70 Met Leu Ala Leu Thr Asp Val Gly Leu Thr 75 80 Leu Ser Thr Leu Pro Thr Thr Leu Ala Val Leu Trp Phe Gly His Arg 85 90 95 Leu Ile Gly Phe Asn Ala Cys Leu Val Gln Met Phe Phe Leu His Ser 100 105 110 Phe Ser Val Val Glu Ser Ser Val Leu Leu Ala Met Ser Phe Asp Arg 115 120 125 Phe Val Ala Ile Ser Asn Pro Leu Arg Tyr Ala Thr Val Leu Thr Asn 130 135 140 Asn Val Ile Ile Arg Ile Gly Met Ala Ile Val Ala Arg Ala Ala Leu 145 150 155 160 Ser Leu Phe Pro Val Pro Phe Leu Leu Lys Arg Leu Asn Phe Cys Pro 165 170 175 Asn Lys Ile Leu Leu Ser His Ser Phe Cys Phe His Pro Asp Val Met 180 185 190 Arg Arg Ala Cys Ala Asp Ile Thr Ile Asn Ile Phe Tyr Gly Leu Tyr 195 200 205 Val Val Leu Ser Thr Gly Gly Ile Asp Ser Leu Leu Ile Ile Leu Ser 210 215 220 Tyr Ile Leu Ile Leu His Thr Ile Leu Gly Leu Ala Ser Pro Arg Glu 225 230 235 240 Arg Ile Arg Ala Phe Asn Thr Cys Val Ser His Ile Leu Ala Val Phe 245 250 255 Val Phe Phe Ile Pro Gly Ile Thr Thr Ser Met Ile His Arg Phe Gly 260 265 270

Page 3640

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Arg His Leu 275 Ser Pro Ile Ala His Ala Leu Val Ala Tyr Val Tyr Leu 280 285 Val Val Pro Pro Val Leu Asn Pro Ile Ile Tyr Ser Val Lys Ser Lys 290 295 300 Pro Ile Arg Glu Ala Met Leu Arg Met Leu Lys Arg Lys Gly Gln Asp 305 310 315 320

<210> 3257 <211> 963 <212> DNA <213> Felis catus <400> 3257 tcagccttgc ctcttctctc tcagtaatct gagcatggcc tccctgatgg gcttggattt 60 cacactgtaa ataatggggt tgagcacagg gggcaccacc aggtacacat aggcaataag 120 agcatgtaca atgtgaggca ggtgcctgcc aaaacggtgg atcattgaca ctcctatgac 180 tgggatgtag aaaatcagaa cagctaatat atgagaaacg catgtgttga gggcccggac 240 acgctccctg ggagaggcca gacccatcac tgtacgaaga ataagggtat aggacaggaa 300 aataagcaaa gaatctacac ccactgtgga taaaactaca tagagcccat agaggatgtt 360 gacagtaatg tcagcacagg cccgtttcat gacatctgca tggaaacaga aggagtggga 420 caggagaatc ttgccaggac aaaagttcag tcgcttcagt aagaagggcc ctggaaagag 480 ggatacagtg gcccgagcaa caatggcgat cccgatcctg atgatgacat tattggtgag 540 gacagttgca tagcgaagag ggttcgagat ggccacaaag cggtcaaatg acatggccag 600 gagcaccgac gactccacca cagagaagga atggaggaag aacatctgga ccaggcaggc 660 attgaagcct atgagcctgt ggtcaaacca gagcacagcc aaggtggtgg gcagtgtgga 720 cagggtgagg cccacgtcgg tgagggccag catggacaag aagtagtaca tgggctggtg 780 caggctggga gtcttcctca cagccaagag gatcaggcag tttccagtga gggccacagt 840 gtacatggag gagaagggga tagagatcca tccatgaaca gcctcatgcc ctgggatgcc 900 aatcatcagg aaggcatgtg gctggaagaa ggagatgttg acataggtct gggaagggag 960 cat 963

Page 3641

069269_0225_SL.TXT <210> 3258 <211> 320 <212> PRT <213> Felis catus

<400> 3258 Val Asn Ile Ser Phe Phe Gln Pro His Met 1 Leu Pro Ser Gln 5 Thr Tyr 10 15 Ala Phe Leu Met Ile Gly Ile Pro Gly His Glu Ala Val His Gly Trp 20 25 30 Ile Ser Ile Pro Phe Ser Ser Met Tyr Thr Val Ala Leu Thr Gly Asn 35 40 45 Cys Leu Ile Leu Leu Ala Val Arg Lys Thr Pro Ser Leu His Gln Pro 50 55 60 Met Tyr Tyr Phe Leu Ser Met Leu Ala Leu Thr Asp Val Gly Leu Thr 65 70 75 80 Leu Ser Thr Leu Pro Thr Thr Leu Ala Val Leu Trp Phe Asp His Arg 85 90 95 Leu Ile Gly Phe Asn Ala Cys Leu Val Gln Met Phe Phe Leu His Ser 100 105 110 Phe Ser Val Val Glu Ser Ser Val Leu Leu Ala Met Ser Phe Asp Arg 115 120 125 Phe Val Ala Ile Ser Asn Pro Leu Arg Tyr Ala Thr Val Leu Thr Asn 130 135 140 Asn Val Ile Ile Arg Ile Gly Ile Ala Ile Val Ala Arg Ala Thr Val 145 150 155 160 Ser Leu Phe Pro Gly Pro Phe Leu Leu Lys Arg Leu Asn Phe Cys Pro 165 170 175

Page 3642

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Gly Lys Ile Leu 180 Leu Ser His Ser Phe Cys Phe His Ala Asp Val Met 185 190 Lys Arg Ala Cys Ala Asp Ile Thr Val Asn Ile Leu Tyr Gly Leu Tyr 195 200 205 Val Val Leu Ser Thr Val Gly Val Asp Ser Leu Leu Ile Phe Leu Ser 210 215 220 Tyr Thr Leu Ile Leu Arg Thr Val Met Gly Leu Ala Ser Pro Arg Glu 225 230 235 240 Arg Val Arg Ala Leu Asn Thr Cys Val Ser His Ile Leu Ala Val Leu 245 250 255 Ile Phe Tyr Ile Pro Val Ile Gly Val Ser Met Ile His Arg Phe Gly 260 265 270 Arg His Leu Pro His Ile Val His Ala Leu Ile Ala Tyr Val Tyr Leu 275 280 285 Val Val Pro Pro Val Leu Asn Pro Ile Ile Tyr Ser Val Lys Ser Lys 290 295 300 Pro Ile Arg Glu Ala Met Leu Arg Leu Leu Arg Glu Lys Arg Gln Gly 305 310 315 320

<210> 3259 <211> 971 <212> DNA <213> Felis catus <400> 3259 tcacctgctt cccacagcct gagggtcctt gtcacagctg atcttgaaca tagctagcat ccgagttctg atctttttgg tcttggcacc atagatgatg ggattgatca caggaggcag aagtagatag acatcaccca taagaacatg cacgatgggg tcaaggcctt ttccaaaacg gtgaaccact gagagtccaa tgagaggaac atagaaggct aaaaccacac cgatgtgtga cacacaggtt ccaaaagcct tggcccgctc tgacttggaa ggcagttgta gaactgttcg

120

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Page 3643

069269_0225_SL.TXT tataatcaga aaataggaca aggagatgaa gaggacatcc acgcccataa ccagcagaat ggcagtaaga ccatagacct cattgggcaa tgtgtctgca taggccaact tcatcatatc ctggtgcacg caataggagt gtgagagcac attggagtgg cagaaggcca gccgcttgat gagcagaggc agtgggataa agaagaggga tccacggacc acggccacca tgccaatctg ggctgttact gtattgttga gcactgctgc gtggcgtagt gggtgacaga tggctatata acggtcaaag gccatggcca gcaggatggt ggactcaata gctgagaggg catgaataaa aaacatctgg gcaatgcagg catcataggt aatctcccgg gaatcaaacc agaagagggc gaggatcttg ggcatggtgg atgtggacaa tgccaggtca atggctgcca acatgcagag aaagaggtac atgggagcat gcaggctgcg ctccgtcctt acgatgaaca ccacgatgca gtttccaaac actgctacag catacattga aagcaggggg aagccgatcc agaaatgggc ttcttctaat ccggggatac caatgagtac aaaggtggca tgtgtgaaat tgcaggaact catagctggc a <210> 3260 <211> 320 <212> PRT <213> Felis catus

360

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900

960

971

<400> 3260 Asn Phe 5 Thr His Ala Thr Phe Val Leu Ile Gly Ile Met Ser 1 Ser Cys 10 15 Pro Gly Leu Glu Glu Ala His Phe Trp Ile Gly Phe Pro Leu Leu Ser 20 25 30 Met Tyr Ala Val Ala Val Phe Gly Asn Cys Ile Val Val Phe Ile Val 35 40 45 Arg Thr Glu Arg Ser Leu His Ala Pro Met Tyr Leu Phe Leu Cys Met 50 55 60 Leu Ala Ala Ile Asp Leu Ala Leu Ser Thr Ser Thr Met Pro Lys Ile 65 70 75 80 Leu Ala Leu Phe Trp Phe Asp Ser Arg Glu Ile Thr Tyr Asp Ala Cys Page 3644

069269_0225_SL.TXT

85 90 95

Ile Ala Gln Met Phe Phe Ile His Ala Leu Ser Ala Ile Glu Ser Thr 100 105 110 Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys His Pro 115 120 125 Leu Arg His Ala Ala Val Leu Asn Asn Thr Val Thr Ala Gln Ile Gly 130 135 140 Met Val Ala Val Val Arg Gly Ser Leu Phe Phe Ile Pro Leu Pro Leu 145 150 155 160 Leu Ile Lys Arg Leu Ala Phe Cys His Ser Asn Val Leu Ser His Ser 165 170 175 Tyr Cys Val His Gln Asp Met Met Lys Leu Ala Tyr Ala Asp Thr Leu 180 185 190 Pro Asn Glu Val Tyr Gly Leu Thr Ala Ile Leu Leu Val Met Gly Val 195 200 205 Asp Val Leu Phe Ile Ser Leu Ser Tyr Phe Leu Ile Ile Arg Thr Val 210 215 220 Leu Gln Leu Pro Ser Lys Ser Glu Arg Ala Lys Ala Phe Gly Thr Cys 225 230 235 240 Val Ser His Ile Gly Val Val Leu Ala Phe Tyr Val Pro Leu Ile Gly 245 250 255 Leu Ser Val Val His Arg Phe Gly Lys Gly Leu Asp Pro Ile Val His 260 265 270 Val Leu Met Gly Asp Val Tyr Leu Leu Leu Pro Pro Val Ile Asn Pro 275 280 285 Ile Ile Tyr Gly Ala Lys Thr Lys Lys Ile Arg Thr Arg Met Leu Ala

Page 3645

069269_0225_SL.TXT

290 295 300

Met Phe Lys Ile Ser Cys Asp Lys Asp Pro Gln Ala Val Gly Ser Arg 305 310 315 320 <210> 3261 <211> 941 <212> DNA <213> Felis catus <400> 3261

atgccatcct tcaatcagag cattttccac cctgcagtct tctttcttac tggcatccct 60 ggctttgaaa cttaccatgc ctggctctcc atcccttttt gttgtctcta tgccattgcc 120 atctctggga atggcatgat cctgtttgtg atcttcactg agtcgagcct ccatgaaccc 180 atgtactatt tcctctccat gctatctttc acggacctag gactatgcct ttccacattg 240 gtcaccatgc tgggtatttt ctggttcaat gctcgagaaa ttagttttga tgcctgcatt 300 ggtcaaatgt tctttatcca tggtttcaca ttcatggagt cctcagtact cctggcgatg 360 gcctttgatc gcttcactgc catctgtaac ccactgagat atgccacaat cttaaccaat 420 tcaaggatca tcaaagtggg ctttgccatt gttattaggg ggacaacggc tctagtgcct 480 ttactcctgc tcctaaagcg tctttctgcc atggccatgt tctgcaccat tcatattgtt 540 tccaccctga tgtgatgacg ctttcatgca cagataccaa gatcaacagt gcatttggtt 600 tggccattgt catatcaact gctggcctag actctgtgtt tatcctcctt tcctatgttc 660 tgatcatcca ctctgtgctc aacatggcct ccccagagga gcagaaaaag gtctttggta 720 cctgtgtctc acacataagt gctgttgcca tcttctacat tcccatgatc agcttgtcac 780 tggtgcatag atttgggaag caagcccctc cccttgtgca cactctcatt gccaatgttt 840 atctgctcat ccctcctgtg atgaatccca taatctacag tgtgaaaacc aagcaaattc 900 gtaaggcagt gctcaaaata ttcctttcta agatgattta g 941

<210> 3262 <211> 184 <212> PRT <213> Felis catus <400> 3262

Page 3646

Met 1 Pro Ser Phe Asn 5 Gln Ser 069269_0225_SL.TXT Ile Phe His Pro Ala Val 10 Phe Phe 15 Leu Thr Gly Ile Pro Gly Phe Glu Thr Tyr His Ala Trp Leu Ser Ile Pro 20 25 30 Phe Cys Cys Leu Tyr Ala Ile Ala Ile Ser Gly Asn Gly Met Ile Leu 35 40 45 Phe Val Ile Phe Thr Glu Ser Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ser Phe Thr Asp Leu Gly Leu Cys Leu Ser Thr Leu 65 70 75 80 Val Thr Met Leu Gly Ile Phe Trp Phe Asn Ala Arg Glu Ile Ser Phe 85 90 95 Asp Ala Cys Ile Gly Gln Met Phe Phe Ile His Gly Phe Thr Phe Met 100 105 110 Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Phe Thr Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asn Ser Arg Ile Ile 130 135 140 Lys Val Gly Phe Ala Ile Val Ile Arg Gly Thr Thr Ala Leu Val Pro 145 150 155 160 Leu Leu Leu Leu Leu Lys Arg Leu Ser Ala Met Ala Met Phe Cys Thr 165 170 175 Ile His Ile Val Ser Thr Leu Met

<210> 3263 <211> 926 <212> DNA <213> Felis catus

180

Page 3647

069269_0225_SL.TXT <400> 3263

aactttccag aataccacag ctatgtccat cattttccta ctaactgatg tttctgggtt 60 ggaagtcttc cacacctgga tctccattcc cttctgcttt ctctacataa ccaacctctc 120 tggaaacagc ctgattctct ttgccattgt cactcagccc agcctccacg aacccatgta 180 ttatttcctc tccatgctgc ccaccactga cctcggcctg tccatatcta ccctggtcac 240 catgttgggt atattctggt ttgatgccag ggagatcagc tttaatgcct gcctgtcaca 300 gatgtttttc attcaacttt acattgtcat ggagtcctca gtgctgttgg ccatggcctt 360 tgatcgtttt gtggccatct ctaatcctct tagatatgct tctatcttaa ctgagcttaa 420 aatagcacag attggaatag caatcatcac cagggggcac taatccagac tcctatggtg 480 ttgcttctta aacgattgcc cttttgccac agccatgtgc tccaccactc atactgcttc 540 taccctgacg tgatgaagct ctcgtgcaca gacaccagga tcaacagcgc agtggggttc 600 acagccctga tcaccactgc tggggtagac tcggtcttca ttattttttc taacttgtta 660 atcgttaaga ctgtcttcag cattgcatct ttgaaagaga ggaagaaagc cttcagcaca 720 tgtatctccc atattggggc tgttgctgta ttctacattc cattgattag tctgtccttt 780 gttcacagat ttggaaatgg gccccacctt atgtacatat cctggttgcc aatacctacc 840 tgttaatccc cctgtgctga accccatcat ctacagtgtg aagaccaaac agatacgcag 900 agctgtgctg aaagttctcc atccca 926

<210> 3264 <211> 153 <212> PRT <213> Felis catus <400> 3264

Thr 1 Phe Gln Asn Thr Thr Ala Met Ser Ile Ile Phe Leu Leu Thr Asp 5 10 15 Val Ser Gly Leu Glu Val Phe His Thr Trp Ile Ser Ile Pro Phe Cys 20 25 30 Phe Leu Tyr Ile Thr Asn Leu Ser Gly Asn Ser Leu Ile Leu Phe Ala 35 40 45

Page 3648

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Ile Val Thr Gln Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Met Leu Pro Thr Thr Asp Leu Gly Leu Ser Ile Ser Thr Leu Val Thr 65 70 75 80 Met Leu Gly Ile Phe Trp Phe Asp Ala Arg Glu Ile Ser Phe Asn Ala 85 90 95 Cys Leu Ser Gln Met Phe Phe Ile Gln Leu Tyr Ile Val Met Glu Ser 100 105 110 Ser Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Ser Asn 115 120 125 Pro Leu Arg Tyr Ala Ser Ile Leu Thr Glu Leu Lys Ile Ala Gln Ile 130 135 140 Gly Ile Ala Ile Ile Thr Arg Gly His 145 150

<210> 3265 <211> 945 <212> DNA <213> Felis catus <400> 3265 ttaaatatga gttcccttgg aacataccag tttgagcaca gatttttgaa tctgctttgt 60 tttcacacta taaatgatgg gattcattac agggggaatg agcaagtaaa tattagcaat 120 cagtgtgggc acatatggtg gagaatgttt tccaaatctg tgaacaaaag acaggctgat 180 taaagggatg tagaatatgg ccacagccgt gatatgagaa atgcaggtgc tgaaggcctt 240 tttcctctcc tctggggatg caatgttgag aactgagcaa attatcagga cataggaaat 300 caggataaaa atagagtcca ctccagcagt agagataatt gcagtgagtc caaacgcact 360 gttgatcttt gtgtctgaac acgagagctt cattacatca ggatggaaac agtaggaatg 420 atggagcaca tgactgcggc agaacgatag acgcttgaga agaaggacta gtggtatcag 480 aatgacagtt cccctggtaa cgactgccaa accaatctgt gcaatccttt catgagttag 540

Page 3649

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aatggtagcg tatctcaagg ggttggaaat ggccacaaaa cgatcaaaag ccatagccag 600 gagcactgaa gattccatga aagtgaagag gtgaatgaag aacatctgtg ataagcaggc 660 attaaagctg atctccctgg cattgagcca gaatattcct agtactgtca ccagtgtaga 720 gatgcataag ccaatgtcag tggtggacaa catggagagg aaatagtaca tgggctcatg 780 gaggcttggc tcagtgagga ctacgaacag gatcagggta ttcccagaaa gagcagttaa 840 atagaggcag cagaagggga tggaaatcca ggcatgggcc cattcaagtc caggcacccc 900 agtcaagagg aaagtaggga aagtagaatt atggaaaact ggcat 945

<210> 3266 <211> 314 <212> PRT <213> Felis catus

<400> 3266 Asn Ser Thr Phe Pro Thr Phe Leu Leu Thr Gly Met 1 Pro Val Phe His 5 10 15 Val Pro Gly Leu Glu Trp Ala His Ala Trp Ile Ser Ile Pro Phe Cys 20 25 30 Cys Leu Tyr Leu Thr Ala Leu Ser Gly Asn Thr Leu Ile Leu Phe Val 35 40 45 Val Leu Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Met Leu Ser Thr Thr Asp Ile Gly Leu Cys Ile Ser Thr Leu Val Thr 65 70 75 80 Val Leu Gly Ile Phe Trp Leu Asn Ala Arg Glu Ile Ser Phe Asn Ala 85 90 95 Cys Leu Ser Gln Met Phe Phe Ile His Leu Phe Thr Phe Met Glu Ser 100 105 110 Ser Val Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Ser Asn 115 120 125

Page 3650

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Pro Leu Arg Tyr Ala Thr Ile Leu Thr His Glu Arg Ile Ala Gln Ile 130 135 140 Gly Leu Ala Val Val Thr Arg Gly Thr Val Ile Leu Ile Pro Leu Val 145 150 155 160 Leu Leu Leu Lys Arg Leu Ser Phe Cys Arg Ser His Val Leu His His 165 170 175 Ser Tyr Cys Phe His Pro Asp Val Met Lys Leu Ser Cys Ser Asp Thr 180 185 190 Lys Ile Asn Ser Ala Phe Gly Leu Thr Ala Ile Ile Ser Thr Ala Gly 195 200 205 Val Asp Ser Ile Phe Ile Leu Ile Ser Tyr Val Leu Ile Ile Cys Ser 210 215 220 Val Leu Asn Ile Ala Ser Pro Glu Glu Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ile Ser His Ile Thr Ala Val Ala Ile Phe Tyr Ile Pro Leu Ile 245 250 255 Ser Leu Ser Phe Val His Arg Phe Gly Lys His Ser Pro Pro Tyr Val 260 265 270 Pro Thr Leu Ile Ala Asn Ile Tyr Leu Leu Ile Pro Pro Val Met Asn 275 280 285 Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Gln Lys Ser Val Leu 290 295 300 Lys Leu Val Cys Ser Lys Gly Thr His Ile 305 310

<210> 3267 <211> 965

Page 3651

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 3267 tctgtttgtt ttgcaaggag aagactgagt atagctttgc gaatctgttt tgtttttaca 60 ctatagatga tggggttgag cactggagga aaaagcaggt atatattagc catcatcgaa 120 tggaccactt tgggggctga tggaccatag cgatgcacca aggataggct catcatgggg 180 atgtagaaaa tagcgaccgc tccaatgtgg gacacacaag tgctgaagac cttatggcgt 240 tcttcagggg aggcaatacg gaccacacag cgaatgatca agatatatga caggataatg 300 catggtgtat ctactcctgt ggtcaggatg agatcaatta atccacagat gctgttggcc 360 tgagtatctg aacatgctaa tttaatcaca tctgggtggt agcagtagga gtgggaaagg 420 acattttctc tacagaaata gagaggctta aggagcaaaa gtagtggtac tattaatact 480 acactacgta taatcattaa caagctcatc tgaattattc tggaattagt gagaatagta 540 gtatacctca gaggatcaca gatggccaca tagcggtcaa aagccatagc caccagcacc 600 ccagattcta tgaatgtaaa tccatgaaga aaaaacatct ggataatgca ggtatctaga 660 ttgacttctg ttgcatcaaa ccagaggata cctaatgttg ttgacattgt agaaatggcc 720 aaccccaagt cagcagttga aagcatagag aggaaatagt acatgggttc atggagactc 780 tgctgggtga tgatgacaaa caggatcatg ctgttcccag agagggcaat ggcatagaga 840 cagcagaagg ggatagaaat ccacgcatgg acagactcta ggccaggaat tccagtcaat 900 aagaaggttg gaaatttaga tgtcaagtta cttaagatct gcatgttttc ctggattcat 960 agcat 965 <210> 3268 <211> 315 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (315)..(315) <223> Any amino acid <400> 3268

Met Gln Ile Leu Ser Asn Leu Thr Ser Lys Phe Pro Thr Phe Leu Leu Page 3652

0 6926 9_02 25_S L.TX T 1 5 10 15 Thr Gly Ile Pro Gly Leu Glu Ser Val His Ala Trp Ile Ser Ile Pro 20 25 30 Phe Cys Cys Leu Tyr Ala Ile Ala Leu Ser Gly Asn Ser Met Ile Leu 35 40 45 Phe Val Ile Ile Thr Gln Gln Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ser Thr Ala Asp Leu Gly Leu Ala Ile Ser Thr Met 65 70 75 80 Ser Thr Thr Leu Gly Ile Leu Trp Phe Asp Ala Thr Glu Val Asn Leu 85 90 95 Asp Thr Cys Ile Ile Gln Met Phe Phe Leu His Gly Phe Thr Phe Ile 100 105 110 Glu Ser Gly Val Leu Val Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg Tyr Thr Thr Ile Leu Thr Asn Ser Arg Ile Ile 130 135 140 Gln Met Ser Leu Leu Met Ile Ile Arg Ser Val Val Leu Ile Val Pro 145 150 155 160 Leu Leu Leu Leu Leu Lys Pro Leu Tyr Phe Cys Arg Glu Asn Val Leu 165 170 175 Ser His Ser Tyr Cys Tyr His Pro Asp Val Ile Lys Leu Ala Cys Ser 180 185 190 Asp Thr Gln Ala Asn Ser Ile Cys Gly Leu Ile Asp Leu Ile Leu Thr 195 200 205 Thr Gly Val Asp Thr Pro Cys Ile Ile Leu Ser Tyr Ile Leu Ile Ile

Page 3653

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210 215 220 Arg Cys Val Val Arg Ile Ala Ser Pro Glu Glu Arg His Lys Val Phe 225 230 235 240 Ser Thr Cys Val Ser His Ile Gly Ala Val Ala Ile Phe Tyr Ile Pro 245 250 255 Met Met Ser Leu Ser Leu Val His Arg Tyr Gly Pro Ser Ala Pro Lys 260 265 270 Val Val His Ser Met Met Ala Asn Ile Tyr Leu Leu Phe Pro Pro Val 275 280 285 Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Arg Lys Ala 290 295 300 Ile Leu Ser Leu Leu Leu Ala Lys Gln Thr Xaa 305 310 315

<210> 3269 <211> 973 <212> DNA <213> Felis catus <400> 3269

ggttggctat gttgccatga cccttggctc agggatcttt tccacaaaat ccttgaataa 60 ccctgttcct gatctgcttg gttctaactc catagatgat ggggttgagc atgggaggaa 120 ccaggagata gagattggca aacatgatat gtactgctcg gggcacatga tgtccaaagc 180 ggtgggtgag aaaagtgaag agggcaggga tatataaagc caagatgaca cagatatggg 240 atgcacatgt gccaaaagcc ttgagctggg cttgaccaga aggcaacccc agaacagttc 300 tcaaaatcat cacataggag acactgatga caatcatatc aaagccaacc acagagaagg 360 ccacaaagag cccatatgca cgatttactc tagtgtctgc acacaccagc tttagcacag 420 ccatgtgttc acagtatggc tggggaatga tctggttggg gcagaagggc atcctggaga 480 ccataatgca gaaggggctc accaaaagca atgctctcat catcacagct gctcccaatt 540 tacccactac agctggggtc aggacacttg agtgacggag tgggaagcag atggccacat 600

Page 3654

069269_0225_SL.TXT

aacggtccaa ggccatagcc atgagtaccc cagactccac agaggaaaag gcatggatga 660 agaacacctg gatgaggcag gcatggtatt gagtctcatg agcatgaaac cagagtatag 720 ccagcatttt aggttgggtg gaagacgaga ggaccaggtc agtgatagcc agcatggcta 780 gaaagaggta catgggctca tgcagagtgt ggtcaattcg gattatatgg aggacagtgg 840 tattgccaat tatagccaca acatacatgg cacagagagg aaaggcaatc caaaattggg 900 aattctcgag tcctgggatc ccaagtagga tgaaggacac aggataagat gagtggttcc 960 ctgaagccaa cat 973 <210> 3270 <211> 314 <212> PRT <213> Felis catus <400> 3270 Met Leu Ala Ser Gly Asn His Ser Ser Tyr Pro Val Ser Phe Ile Leu 1 5 10 15 Leu Gly Ile Pro Gly Leu Glu Asn Ser Gln Phe Trp Ile Ala Phe Pro 20 25 30 Leu Cys Ala Met Tyr Val Val Ala Ile Ile Gly Asn Thr Thr Val Leu 35 40 45 His Ile Ile Arg Ile Asp His Thr Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Ala Ile Thr Asp Leu Val Leu Ser Ser Ser Thr Gln 65 70 75 80 Pro Lys Met Leu Ala Ile Leu Trp Phe His Ala His Glu Thr Gln Tyr 85 90 95 His Ala Cys Leu Ile Gln Val Phe Phe Ile His Ala Phe Ser Ser Val 100 105 110 Glu Ser Gly Val Leu Met Ala Met Ala Leu Asp Arg Tyr Val Ala Ile

115 120 125

Page 3655

069269_0225_SL.TXT

Cys Phe Pro Leu Arg His Ser Ser Val Leu Thr Pro Ala Val Val Gly 130 135 140 Lys Leu Gly Ala Ala Val Met Met Arg Ala Leu Leu Leu Val Ser Pro 145 150 155 160 Phe Cys Ile Met Val Ser Arg Met Pro Phe Cys Pro Asn Gln Ile Ile 165 170 175 Pro Gln Pro Tyr Cys Glu His Met Ala Val Leu Lys Leu Val Cys Ala 180 185 190 Asp Thr Arg Val Asn Arg Ala Tyr Gly Leu Phe Val Ala Phe Ser Val 195 200 205 Val Gly Phe Asp Met Ile Val Ile Ser Val Ser Tyr Val Met Ile Leu 210 215 220 Arg Thr Val Leu Gly Leu Pro Ser Gly Gln Ala Gln Leu Lys Ala Phe 225 230 235 240 Gly Thr Cys Ala Ser His Ile Cys Val Ile Leu Ala Leu Tyr Ile Pro 245 250 255 Ala Leu Phe Thr Phe Leu Thr His Arg Phe Gly His His Val Pro Arg 260 265 270 Ala Val His Ile Met Phe Ala Asn Leu Tyr Leu Leu Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Asn Arg 290 295 300 Val Ile Gln Gly Phe Cys Gly Lys Asp Pro 305 310

<210> 3271 <211> 721

Page 3656

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 3271

gcttatccct gtgcacactt cctactaccc ttggtgtttt ctggtttgaa gctcgcgaaa 60 tcaccttaaa tgcctgcatt gcccagatgt tctttctcca tggatttact ttcatggagt 120 ctggggttct attggccatg gcctttgacc gttttgtagc catctgtgat ccactgagat 180 atgccaccat cctcaccaat gccaggattg cccagattgg gataagcatg ttgataagga 240 acgttgctgt aatgttacca gtggtgctct ttgtcaagag gctgtccttc tgccgtgctg 300 tggccctctc acattcttac tgctaccacg tcgatctcat tcaactctca tgcacagaca 360 acagaatcaa cagcatcctt ggtctgtttg cactttttcc acgacggggt ttgattgtcc 420 ttgcatcttg atctcctatg tcctgatcat tcgatctgtt ctcaacattg cctcctctga 480 ggggcggcaa aaagccttca acacctgcat atcccacatc agcgctgttg ccatcttcta 540 catccctctc atcagcttgt ctcttgtcca tcgctatggc cattcagcac ctctgtttgt 600 ccacaccatc atggccaatg tcttccttct catccctcct gtgctcaacc ctatcatcta 660 cagtgtgaag actaagcaga ttcgaaaggc tattgtcaag gtcttaattc agaagcaaca 720

a 721 <210> 3272 <211> 142 <212> PRT <213> Felis catus <400> 3272

Leu Ser Leu Cys Thr Leu Pro Thr Thr Leu Gly Val Phe Trp Phe Glu 1 5 10 15 Ala Arg Glu Ile Thr Leu Asn Ala Cys Ile Ala Gln Met Phe Phe Leu 20 25 30 His Gly Phe Thr Phe Met Glu Ser Gly Val Leu Leu Ala Met Ala Phe 35 40 45 Asp Arg Phe Val Ala Ile Cys Asp Pro Leu Arg Tyr Ala Thr Ile Leu 50 55 60

Page 3657

069269_0225_SL.TXT

Thr 65 Asn Ala Arg Ile Ala Gln Ile Gly Ile Ser Met Leu Ile Arg Asn 80 70 75 Val Ala Val Met Leu Pro Val Val Leu Phe Val Lys Arg Leu Ser Phe 85 90 95 Cys Arg Ala Val Ala Leu Ser His Ser Tyr Cys Tyr His Val Asp Leu 100 105 110 Ile Gln Leu Ser Cys Thr Asp Asn Arg Ile Asn Ser Ile Leu Gly Leu 115 120 125 Phe Ala Leu Phe Pro Arg Arg Gly Leu Ile Val Leu Ala Ser 130 135 140

<210> 3273 <211> 960 <212> DNA <213> Felis catus <400> 3273 atgaaagacc tatttgtgat gttttctctt aatacctcgg aagttgaaat ctccaccttc ctgttggttg ggatcccagg gtttgagagt gtacacattt ggatctccat ccccatctgc tttatgtacc tcctggccat cctgggcaac tgcacccccc tgtttgtcat caggacagag tcttccctgc atgagcctat gtactatttc ctctccatgc tggccctatc tgacctgggc ttgtctttct cttctcttcc ctctatgctg aggatcttct tgttcaatgc catggagatt tctgctgatg catgtattgc ccaggaattt ttcatccatg gattcacagg catggaatcc tcaatgctct tgatcatgtc ctttgattgc tttccagcca tttgcaaccc tctgaggtat aattccattc ttaccagctc cagaattttg catcgtggac tgatatttga tattaaaagc attctactag ttcttcctct tcctttcact ttaaatagac tcagatactg taataaacac ctgctctcac actcctactg tctccaccag gatgtcatga aactggcctg ctctgacaat agggttaact tttactatgg tctgtttgtc gcactctgca tgatgtcaga cagtgttttc attgctgttt cctatgtgtt caacctgaag actgtattgg gtattgcatc ccatggggag caacttaaag ctcttaatac ctgtgtgtcc cacatctgtg ctgtgctcat cttctttgtg Page 3658

120

180

240

300

360

420

480

540

600

660

720

780

069269_0225_SL.TXT cccatcatca ccttggctac catacatcac tttgccaagc ataaatcccc tttggctatg attctgatag ctgatgcatt cttgttggta ccatctttga tgaatcccat tgtgtattgt gtaaaaagtt ggcagattag agtaaaagtc ctggaaaaac tgagtctaaa gtctaaatga

840

900

960 <210> 3274 <211> 319 <212> PRT <213> Felis catus

<400> 3274 Met 1 Lys Asp Leu Phe Val 5 Met Phe Ser Leu Asn Thr Ser Glu Val Glu 10 15 Ile Ser Thr Phe Leu Leu Val Gly Ile Pro Gly Phe Glu Ser Val His 20 25 30 Ile Trp Ile Ser Ile Pro Ile Cys Phe Met Tyr Leu Leu Ala Ile Leu 35 40 45 Gly Asn Cys Thr Pro Leu Phe Val Ile Arg Thr Glu Ser Ser Leu His 50 55 60 Glu Pro Met Tyr Tyr Phe Leu Ser Met Leu Ala Leu Ser Asp Leu Gly 65 70 75 80 Leu Ser Phe Ser Ser Leu Pro Ser Met Leu Arg Ile Phe Leu Phe Asn 85 90 95 Ala Met Glu Ile Ser Ala Asp Ala Cys Ile Ala Gln Glu Phe Phe Ile 100 105 110 His Gly Phe Thr Gly Met Glu Ser Ser Met Leu Leu Ile Met Ser Phe 115 120 125 Asp Cys Phe Pro Ala Ile Cys Asn Pro Leu Arg Tyr Asn Ser Ile Leu 130 135 140 Thr Ser Ser Arg Ile Leu His Arg Gly Leu Ile Phe Asp Ile Lys Ser 145 150 155 160

Page 3659

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Ile Leu Leu Val Leu Pro Leu Pro Phe Thr Leu Asn Arg Leu Arg Tyr 165 170 175 Cys Asn Lys His Leu Leu Ser His Ser Tyr Cys Leu His Gln Asp Val 180 185 190 Met Lys Leu Ala Cys Ser Asp Asn Arg Val Asn Phe Tyr Tyr Gly Leu 195 200 205 Phe Val Ala Leu Cys Met Met Ser Asp Ser Val Phe Ile Ala Val Ser 210 215 220 Tyr Val Phe Asn Leu Lys Thr Val Leu Gly Ile Ala Ser His Gly Glu 225 230 235 240 Gln Leu Lys Ala Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu 245 250 255 Ile Phe Phe Val Pro Ile Ile Thr Leu Ala Thr Ile His His Phe Ala 260 265 270 Lys His Lys Ser Pro Leu Ala Met Ile Leu Ile Ala Asp Ala Phe Leu 275 280 285 Leu Val Pro Ser Leu Met Asn Pro Ile Val Tyr Cys Val Lys Ser Trp 290 295 300 Gln Ile Arg Val Lys Val Leu Glu Lys Leu Ser Leu Lys Ser Lys

305 310 315 <210> 3275 <211> 969 <212> DNA <213> Felis catus <400> 3275 tcattgagca caacccacct tcctgggctg tagtctcttg actattctct ctctaatctc cttcatcttg acactgtaga gaataggatt tatcaatgga ggaaacagga agtggacata

120

Page 3660

069269_0225_SL.TXT

ggagagaaga gtatgggcag gctgaggtat tggcactcta agatggtcaa tgagggcaag 180 aaggatcatg ggcatgtaga agaggagcac agcagagagg tgggcagcac aggtttggcc 240 agccttccag cgatcctcac tggatcccaa accttgcaag actctgccaa ttaagccata 300 ggagaaaaaa ataagcagag ggtctaatcc cataactgac agaaccacaa agaggctata 360 gattgcaccc caagctccag ggcaggccaa atgggctata tctgggtgca agcagtaaga 420 atgggtcagg acctgtggga ggcagtaggg catgtgggcc aggaggaatg gcaggggcag 480 atggagaccc aggcatcgga aagcaatagc caggcaaatc ttgctaatga catcattggt 540 gaggagcgtt gggtagtgga gagggcggca gatggctagt gctcgatcta aggccatggc 600 gagcaacaca gaggactcca tgacagaaaa gatgtggaca aagaacatct gtaggaggca 660 agccgaagca gggacagcat gaacgccagc aaaggcaaga cccagcaggg tgggcatcag 720 ggctgtggcc aagccaacat cagacacgct aagcaagaag aggaagaagt acattggacg 780 gtgcagggtg gaatccaagg caatgatcca gagaatagta ccgttgccca gggcagagag 840 aaggtacatt gtgatgagtg gtattgtcca ccaggagggt gcagctgaca gacctggcat 900 gcccaccaac aagaaggtgg gggccattga agtgttattg ggggctgcct gattggggaa 960

tgttgacat 969 <210> 3276 <211> 322 <212> PRT <213> Felis catus <400> 3276

Met Ser Thr Phe Pro Asn Gln Ala Ala Pro Asn Asn Thr Ser Met Ala 1 5 10 15 Pro Thr Phe Leu Leu Val Gly Met Pro Gly Leu Ser Ala Ala Pro Ser 20 25 30 Trp Trp Thr Ile Pro Leu Ile Thr Met Tyr Leu Leu Ser Ala Leu Gly 35 40 45 Asn Gly Thr Ile Leu Trp Ile Ile Ala Leu Asp Ser Thr Leu His Arg 50 55 60

Page 3661

069269_0225_SL.TXT

Pro 65 Met Tyr Phe Phe Leu Phe Leu Leu Ser Val Ser Asp Val Gly Leu 70 75 80 Ala Thr Ala Leu Met Pro Thr Leu Leu Gly Leu Ala Phe Ala Gly Val 85 90 95 His Ala Val Pro Ala Ser Ala Cys Leu Leu Gln Met Phe Phe Val His 100 105 110 Ile Phe Ser Val Met Glu Ser Ser Val Leu Leu Ala Met Ala Leu Asp 115 120 125 Arg Ala Leu Ala Ile Cys Arg Pro Leu His Tyr Pro Thr Leu Leu Thr 130 135 140 Asn Asp Val Ile Ser Lys Ile Cys Leu Ala Ile Ala Phe Arg Cys Leu 145 150 155 160 Gly Leu His Leu Pro Leu Pro Phe Leu Leu Ala His Met Pro Tyr Cys 165 170 175 Leu Pro Gln Val Leu Thr His Ser Tyr Cys Leu His Pro Asp Ile Ala 180 185 190 His Leu Ala Cys Pro Gly Ala Trp Gly Ala Ile Tyr Ser Leu Phe Val 195 200 205 Val Leu Ser Val Met Gly Leu Asp Pro Leu Leu Ile Phe Phe Ser Tyr 210 215 220 Gly Leu Ile Gly Arg Val Leu Gln Gly Leu Gly Ser Ser Glu Asp Arg 225 230 235 240 Trp Lys Ala Gly Gln Thr Cys Ala Ala His Leu Ser Ala Val Leu Leu 245 250 255 Phe Tyr Met Pro Met Ile Leu Leu Ala Leu Ile Asp His Leu Arg Val 260 265 270

Page 3662

069269_0225_SL.TXT

Pro Ile Pro 275 Gln Pro Ala His Thr Leu Leu Ser Tyr Val His Phe Leu 280 285 Phe Pro Pro Leu Ile Asn Pro Ile Leu Tyr Ser Val Lys Met Lys Glu 290 295 300 Ile Arg Glu Arg Ile Val Lys Arg Leu Gln Pro Arg Lys Val Gly Cys 305 310 315 320

Ala Gln <210> 3277 <211> 957 <212> DNA <213> Felis catus <400> 3277

atggcagata ataaccactc tcacttccaa cacccttact ttgtcttaac gggaattcca 60 gggcttgaac aaaagtatta ctggatagca ttcccactgg gtgctatata tgtcattgcc 120 ctctttggca atggtgttat catctctacc atcaagtctg aatcatccct gcatatcccc 180 atgtactatt ttctctgcat gttggcactg gcagacatgg gacttaccct ctgtactctg 240 ccctctatgc taggcatatt ctggtttaac tataagtcca ttgcctttga ttcctgcctt 300 gttcagatgt acttcattca caccttctca gccattgaat ctggtgtact ggtggccatg 360 gcctttgatc gggttgtagc catctggaac cccctcaggt atgggaccat cataaccaat 420 ggtgtggtct gcagagctgg gacagtcatc ttgacaaggg cagtctgtgt ggtcttccct 480 gtgcctttcc tcatcaagcg acttcccttc taccactcca acatcctctc ccactccttc 540 tgccttcacc aagatgtcat gcgccttgcc tgtgccagca ctcgtatcaa cagtctctat 600 ggccttattg ctgtcatctt caccaagggt tctgactccc tctctatcct cctctcctat 660 gtgttcatac tccgagcggt aatggccatt gcctcagggg agggctggct gaaagcactc 720 aacacctgtg tttcacatat ctgtgctgta ctcatcttct atgttccact cattgggctg 780 tctgtcatcc atcgttttgg aaagcatctt tcaccactga ctcatgtcct catggctaat 840 gcctaccttc ttgtaccccc tgtgctaaac cctatagtct ataccgtgaa gaccaaggag 900

Page 3663

069269_0225_SL.TXT atgagaaaga aaataattca aatatttgtt caaaccaaga tcactgcaga gggttag

957 <210> 3278 <211> 318 <212> PRT <213> Felis catus

<400> 3278 Met 1 Ala Asp Asn Asn 5 His Ser His Phe Gln His Pro Tyr Phe Val Leu 10 15 Thr Gly Ile Pro Gly Leu Glu Gln Lys Tyr Tyr Trp Ile Ala Phe Pro 20 25 30 Leu Gly Ala Ile Tyr Val Ile Ala Leu Phe Gly Asn Gly Val Ile Ile 35 40 45 Ser Thr Ile Lys Ser Glu Ser Ser Leu His Ile Pro Met Tyr Tyr Phe 50 55 60 Leu Cys Met Leu Ala Leu Ala Asp Met Gly Leu Thr Leu Cys Thr Leu 65 70 75 80 Pro Ser Met Leu Gly Ile Phe Trp Phe Asn Tyr Lys Ser Ile Ala Phe 85 90 95 Asp Ser Cys Leu Val Gln Met Tyr Phe Ile His Thr Phe Ser Ala Ile 100 105 110 Glu Ser Gly Val Leu Val Ala Met Ala Phe Asp Arg Val Val Ala Ile 115 120 125 Trp Asn Pro Leu Arg Tyr Gly Thr Ile Ile Thr Asn Gly Val Val Cys 130 135 140 Arg Ala Gly Thr Val Ile Leu Thr Arg Ala Val Cys Val Val Phe Pro 145 150 155 160 Val Pro Phe Leu Ile Lys Arg Leu Pro Phe Tyr His Ser Asn Ile Leu 165 170 175

Page 3664

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Ser His Ser Phe Cys Leu His Gln Asp 185 Val Met Arg Leu Ala 190 Cys Ala 180 Ser Thr Arg Ile Asn Ser Leu Tyr Gly Leu Ile Ala Val Ile Phe Thr 195 200 205 Lys Gly Ser Asp Ser Leu Ser Ile Leu Leu Ser Tyr Val Phe Ile Leu 210 215 220 Arg Ala Val Met Ala Ile Ala Ser Gly Glu Gly Trp Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Ile Phe Tyr Val Pro 245 250 255 Leu Ile Gly Leu Ser Val Ile His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Leu Thr His Val Leu Met Ala Asn Ala Tyr Leu Leu Val Pro Pro Val 275 280 285 Leu Asn Pro Ile Val Tyr Thr Val Lys Thr Lys Glu Met Arg Lys Lys 290 295 300 Ile Ile Gln Ile Phe Val Gln Thr Lys Ile Thr Ala Glu Gly

305 310 315 <210> 3279 <211> 954 <212> DNA <213> Felis catus <400> 3279 ctaggccctg tcttttctcc cctggaacat gtgtaagatc cgccttcgta tctgcttagt cttcacacta tagacaatgg ggtttagtac aggggggagt aacagataga tattggccat gagtgtgtgt actactggtg atagatgctt cccaaatctg tggatcatgg tgacaccaat gagaggaaca tagaagagga gcacagcaca gatgtgagaa aggcaggtgt tgagggcttt

120

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Page 3665

069269_0225_SL.TXT gaccctttca gagaatgatg gttgatgcgg agacaagacg cacacagact gatggaagca taatactcct atcaaaggga catggagaga gagactctca gtagagaaat tgtcaaaatg gttctggaag agagcatcca gtgctggcac ttggaacggc gcccggatga tagcgtaatg gattctacca atctcaggga ctaacatcgg tctaccttga cccaagggaa aaactgtggt caatgcccag gccccaatgt aggctagccg aaaaaggtag ggacagctat ggtctcggat ctccaaatcc cattaaacca tgacagccaa tgacagctaa aggccatcca ggttggcatg cacagtcttc gaagatgact cattgcatct ccgctttata tccgatcttt ggccacaaaa atggatgaaa gaagatgctg gatagagagg gatggttcca tgggttttta tgatgcagtt aggatgagca atgatgaggc tggtggagac aggaatggca ccaatgatgt cggtcaaagg aacatctgtg agcatggagg aagtagtaca tttcccagga tctgacatcc gaattcattg tgtaagaaaa catagagact aatatgaatg caggcaaaac catgggtgag ccatggacac taatgcatgc gcgaggtgga taggctcatg gagttagtgt cagggatacc tcat

300

360

420

480

540

600

660

720

780

840

900

954 <210> 3280 <211> 317 <212> PRT <213> Felis catus

<400> 3280 Ser Thr 5 Ala Ser His Ala Asn His His Ser Phe Ile Met Thr 1 Met Asn 10 15 Leu Thr Gly Ile Pro Gly Met Ser Asp Lys Asn Pro Trp Met Ala Phe 20 25 30 Pro Leu Gly Phe Leu Tyr Thr Leu Thr Leu Leu Gly Asn Gly Thr Ile 35 40 45 Leu Ala Val Ile Lys Val Asp Glu Ser Leu His Glu Pro Met Tyr Tyr 50 55 60 Phe Leu Ser Ile Leu Ala Val Thr Asp Val Ser Leu Ser Met Ser Thr 65 70 75 80 Ser Pro Ser Met Leu Ser Ile Phe Trp Phe Asn Val Pro Glu Ile Pro Page 3666

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85 90 95

Phe Asp Ala Cys Ile Thr Gln Met Phe Phe Ile His Gly Phe Gly Val 100 105 110 Val Glu Ser Gly Val Leu Val Ser Met Ala Phe Asp Arg Phe Val Ala 115 120 125 Ile Arg Asp Pro Leu Arg Tyr Ala Ser Ile Leu Thr His Asp Ile Ile 130 135 140 Gly Lys Ile Gly Ile Ala Val Leu Ile Arg Ala Val Cys Val Val Leu 145 150 155 160 Pro Val Pro Phe Leu Ile Lys Arg Leu Pro Phe Cys Arg Ser Asn Val 165 170 175 Leu Ser His Ser Tyr Cys Leu His Gln Asp Ala Met Arg Leu Ala Cys 180 185 190 Ala Ser Thr Arg Ile Asn Ser Leu Tyr Gly Leu Ile Ile Val Ile Phe 195 200 205 Thr Leu Gly Leu Asp Ala Leu Ile Ile Leu Phe Ser Tyr Met Leu Ile 210 215 220 Leu Lys Thr Val Leu Gly Ile Ala Ser Arg Thr Glu Arg Val Lys Ala 225 230 235 240 Leu Asn Thr Cys Leu Ser His Ile Cys Ala Val Leu Leu Phe Tyr Val 245 250 255 Pro Leu Ile Gly Val Thr Met Ile His Arg Phe Gly Lys His Leu Ser 260 265 270 Pro Val Val His Thr Leu Met Ala Asn Ile Tyr Leu Leu Leu Pro Pro 275 280 285 Val Leu Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile Arg Arg

Page 3667

069269_0225_SL.TXT 290 295 300

Arg Ile Leu His Met Phe Gln Gly Arg Lys Asp Arg Ala 305 310 315

<210> 3281 <211> 951 <212> DNA <213> Felis catus <400> 3281 atgtcactgt tcaaccaaac tattcataac catcagacct ttaccctgat tgggattcca 60 ggaatgccag agaaagactt ctggatggcc ttgcccctct gccttcttta cagtaccaca 120 ttcctaggta atttcattat ccttgttgtc ataaaggttg agcgaagtct ccatgaaccc 180 atgtattatt ttctggctat gctagctgcc actgacctta gcctttcatt atcttccatg 240 cccaccatga taagtgttca cttgtttgac tggcgctcag taacccttga tgtctgcatc 300 actcagatgt tctttatcca caactttgga ggagtggaat caggtgttct ggtcgccatg 360 gcctttgatc gctttgtggc tattcgcttc cctttgcgct atgccaccat tctcactcat 420 ggagtcatca tcaaaattgg agcagcagtc ctgctacgga gtgtgagtgt agtgctccct 480 gtgcctttcc tcatcaaaag gctacctttc tgccactcca atgtcctttc ccacgcatac 540 tgcctccatc aggatgccat gaggcttgcc tgtgctgaca cccgtgtcaa tagcatctat 600 ggtctgctgg ctgtgatctt catcattgta ctagatgcct tgatcctttt gatttcttac 660 tttctaatcc tccatgcagt actgggcatt gcttccagag aagagagact taaggctctt 720 aatacctgct tctctcatat ctgtgcagta ctgctcttct atgtgcctct cattggcatg 780 actctgattc accgctttgg gaagcatttg tcaccagtaa tacccacact tatggccaat 840 atctacctgc tgctccctcc tctgctcaat cctgttgtgt acagtgttag gaccaagcag 900 atccggcagc ggattgtccg agcattctgt gggaacagga ttggccatta a 951 <210> 3282 <211> 316 <212> PRT <213> Felis catus <400> 3282

Page 3668

Met 1 Ser Leu Phe Asn 5 Gln Thr 069269_0225_SL.TXT Ile His Asn His Gln Thr 10 Phe Thr 15 Leu Ile Gly Ile Pro Gly Met Pro Glu Lys Asp Phe Trp Met Ala Leu Pro 20 25 30 Leu Cys Leu Leu Tyr Ser Thr Thr Phe Leu Gly Asn Phe Ile Ile Leu 35 40 45 Val Val Ile Lys Val Glu Arg Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Met Leu Ala Ala Thr Asp Leu Ser Leu Ser Leu Ser Ser Met 65 70 75 80 Pro Thr Met Ile Ser Val His Leu Phe Asp Trp Arg Ser Val Thr Leu 85 90 95 Asp Val Cys Ile Thr Gln Met Phe Phe Ile His Asn Phe Gly Gly Val 100 105 110 Glu Ser Gly Val Leu Val Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Arg Phe Pro Leu Arg Tyr Ala Thr Ile Leu Thr His Gly Val Ile Ile 130 135 140 Lys Ile Gly Ala Ala Val Leu Leu Arg Ser Val Ser Val Val Leu Pro 145 150 155 160 Val Pro Phe Leu Ile Lys Arg Leu Pro Phe Cys His Ser Asn Val Leu 165 170 175 Ser His Ala Tyr Cys Leu His Gln Asp Ala Met Arg Leu Ala Cys Ala 180 185 190 Asp Thr Arg Val Asn Ser Ile Tyr Gly Leu Leu Ala Val Ile Phe Ile 195 200 205

Page 3669

069269_0225_SL.TXT

Ile Val Leu Asp Ala Leu Ile Leu Leu Ile Ser Tyr Phe Leu Ile Leu 210 215 220 His Ala Val Leu Gly Ile Ala Ser Arg Glu Glu Arg Leu Lys Ala Leu 225 230 235 240 Asn Thr Cys Phe Ser His Ile Cys Ala Val Leu Leu Phe Tyr Val Pro 245 250 255 Leu Ile Gly Met Thr Leu Ile His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Val Ile Pro Thr Leu Met Ala Asn Ile Tyr Leu Leu Leu Pro Pro Leu 275 280 285 Leu Asn Pro Val Val Tyr Ser Val Arg Thr Lys Gln Ile Arg Gln Arg 290 295 300 Ile Val Arg Ala Phe Cys Gly Asn Arg Ile Gly His

305 310 315

<210> 3283 <211> 978 <212> DNA <213> Felis catus <400> 3283 attttcaata atactacatc atcttcctca aacttcctac tcactgcatt tcctggtctg 60 gaacttgcac atgtctggat ctctattcct gtctgctgtc tctatgccat tgccctcttg 120 ggaaacagca cgattctgct cgtcatcatt gttgagagga gtcttcacaa gcccatgtac 180 tatttcctcg ccatgctgtc agctgttgat ctatgtctga ccatctcaac ccttcccact 240 gttcttgggg ttctctggtt tcatgcccgg gagattagct tgaaagcttg cctcattcaa 300 atgttctttg tacatggctt ctccttcctg gagtcttcag tgctggtagc catggccttt 360 gaccgcctca tggctatctg taacccactg aagtatgcta ttgtcttcac agacatgata 420 atcttggtga ttggactggt catctgcata cggcaagtaa ttttaatctt tcccatgatt 480 ctagccttga cgagagtatc ttttcacgga ggccaagagc tttcccaccc attttgctac 540

Page 3670

069269_0225_SL.TXT

catccagaca tgattaaata cacatattcc aacccctgga tcagcaattt tttgggcatg 600 tttcttcagc tctacctgac tggcactgac ttactgttca ttcttttctc ctacgttctg 660 attctccgaa ccgtcttgag tatcgtggcc cctaagaaac aacaaaaagc tctcagcact 720 tgtgtctgtc acatctgtgc tgtcactgtt ttctatgtgc caatgatcag cctgtccttt 780 acacaccgcc ttttcagctc caccccaaaa gtggtctgta gcattttggc caatgtttat 840 ttgttcttac cacctgtact gaaccctgtc atttacagct tgaagaccaa gaccatccga 900 caggctatgc tccagctgct ccactttaag ggctcacagg gccccagtgt gaggagtcat 960 agaggaccct ggggttga 978

<210> 3284 <211> 325 <212> PRT <213> Felis catus

<400> 3284 Thr Ser Ser Ser Ser Asn Phe Leu Leu Thr Ala Ile Phe 1 Asn Asn Thr 5 10 15 Phe Pro Gly Leu Glu Leu Ala His Val Trp Ile Ser Ile Pro Val Cys 20 25 30 Cys Leu Tyr Ala Ile Ala Leu Leu Gly Asn Ser Thr Ile Leu Leu Val 35 40 45 Ile Ile Val Glu Arg Ser Leu His Lys Pro Met Tyr Tyr Phe Leu Ala 50 55 60 Met Leu Ser Ala Val Asp Leu Cys Leu Thr Ile Ser Thr Leu Pro Thr 65 70 75 80 Val Leu Gly Val Leu Trp Phe His Ala Arg Glu Ile Ser Leu Lys Ala 85 90 95 Cys Leu Ile Gln Met Phe Phe Val His Gly Phe Ser Phe Leu Glu Ser 100 105 110

Ser Val

Leu Val Ala Met

Ala

Phe Asp Arg Leu Met Ala Page 3671

Ile Cys Asn

069269_0225_SL.TXT

115 120 125 Pro Leu Lys Tyr Ala Ile Val Phe Thr Asp Met Ile Ile Leu Val Ile 130 135 140 Gly Leu Val Ile Cys Ile Arg Gln Val Ile Leu Ile Phe Pro Met Ile 145 150 155 160 Leu Ala Leu Thr Arg Val Ser Phe His Gly Gly Gln Glu Leu Ser His 165 170 175 Pro Phe Cys Tyr His Pro Asp Met Ile Lys Tyr Thr Tyr Ser Asn Pro 180 185 190 Trp Ile Ser Asn Phe Leu Gly Met Phe Leu Gln Leu Tyr Leu Thr Gly 195 200 205 Thr Asp Leu Leu Phe Ile Leu Phe Ser Tyr Val Leu Ile Leu Arg Thr 210 215 220 Val Leu Ser Ile Val Ala Pro Lys Lys Gln Gln Lys Ala Leu Ser Thr 225 230 235 240 Cys Val Cys His Ile Cys Ala Val Thr Val Phe Tyr Val Pro Met Ile 245 250 255 Ser Leu Ser Phe Thr His Arg Leu Phe Ser Ser Thr Pro Lys Val Val 260 265 270 Cys Ser Ile Leu Ala Asn Val Tyr Leu Phe Leu Pro Pro Val Leu Asn 275 280 285 Pro Val Ile Tyr Ser Leu Lys Thr Lys Thr Ile Arg Gln Ala Met Leu 290 295 300 Gln Leu Leu His Phe Lys Gly Ser Gln Gly Pro Ser Val Arg Ser His 305 310 315 320 Arg Gly Pro Trp Gly

Page 3672

069269_0225_SL.TXT

325 <210> 3285 <211> 926 <212> DNA <213> Felis catus <400> 3285

ttattttaga cataatttcc cccaaacctt ctcacgaatt tgctgcgtct tcacacagta 60 tacaatggga ttcaccagag gtggtactag taagaaaacg tccgcaatga ggatcatggc 120 cactggggac ttgtgcttgc caaaacggtg catggaggcc aaagcaatga tgggcacata 180 gaagatgagc acagcacaga tgtgggagac acaggtgttg agagccttga gccgctcctt 240 atgggatcca attcccatca ctgtcttcag gatgaatatg taggacacaa caatgaacac 300 actgtctgac atcatacaga gggcaacaaa gaaaccatag aaaaagttga ctgtgttgtc 360 agagcaggcc agcttcatga catcctggtg tagacaataa gagtgagaaa gtaggctttt 420 cctacaatat gtcaattttt tgagagtgaa agggaatggg aggactaaga gcatgctttt 480 aattagaaac accaggccca ttttggcaac tctggcattg gtgaggatag agctatatct 540 cagagggtga cgtatggcca aaaagcggtc aaaagacatg gccaggagca ctgaggactc 600 catatctgta aatccgtgga taaagaattc ttgagcaaag caggcatttg gggaaattcc 660 tgtagcattg aaaacaaata tcctcagcat agtggggagg gatgagaggg agaggcccaa 720 gtcagagaca gccaacccag aaaggaaata gtacatgggt gcatggagtg aggactctgt 780 cctgatcaca aagaggatgg tgcagttgcc aaagatggcc accaggtaca tgaagcagat 840 ggggacagag atccaagcat gaatatgttc cagtcctggg attccaatca ggaagaaggt 900 ggtgatctca atgttagagg aattga 926

<210> 3286 <211> 307 <212> PRT <213> Felis catus <400> 3286

Asn Ser Ser Asn Ile Glu Ile Thr Thr Phe Phe Leu Ile Gly Ile Pro 1 5 10 15

Page 3673

Gly Leu Glu His 20 Ile His Ala 069269_0225_SL.TXT Trp Ile Ser Val Pro Ile 25 Cys 30 Phe Met Tyr Leu Val Ala Ile Phe Gly Asn Cys Thr Ile Leu Phe Val Ile Arg 35 40 45 Thr Glu Ser Ser Leu His Ala Pro Met Tyr Tyr Phe Leu Ser Gly Leu 50 55 60 Ala Val Ser Asp Leu Gly Leu Ser Leu Ser Ser Leu Pro Thr Met Leu 65 70 75 80 Arg Ile Phe Val Phe Asn Ala Thr Gly Ile Ser Pro Asn Ala Cys Phe 85 90 95 Ala Gln Glu Phe Phe Ile His Gly Phe Thr Asp Met Glu Ser Ser Val 100 105 110 Leu Leu Ala Met Ser Phe Asp Arg Phe Leu Ala Ile Arg His Pro Leu 115 120 125 Arg Tyr Ser Ser Ile Leu Thr Asn Ala Arg Val Ala Lys Met Gly Leu 130 135 140 Val Phe Leu Ile Lys Ser Met Leu Leu Val Leu Pro Phe Pro Phe Thr 145 150 155 160 Leu Lys Lys Leu Thr Tyr Cys Arg Lys Ser Leu Leu Ser His Ser Tyr 165 170 175 Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ser Asp Asn Thr Val 180 185 190 Asn Phe Phe Tyr Gly Phe Phe Val Ala Leu Cys Met Met Ser Asp Ser 195 200 205 Val Phe Ile Val Val Ser Tyr Ile Phe Ile Leu Lys Thr Val Met Gly 210 215 220

Page 3674

Ile 225 Gly Ser His Lys Glu 230 Arg 069269_0225_SL.TXT Leu Lys Ala Leu Asn Thr 235 Cys Val Ser 240 His Ile Cys Ala Val Leu Ile Phe Tyr Val Pro Ile Ile Ala Leu Ala 245 250 255 Ser Met His Arg Phe Gly Lys His Lys Ser Pro Val Ala Met Ile Leu 260 265 270 Ile Ala Asp Val Phe Leu Leu Val Pro Pro Leu Val Asn Pro Ile Val 275 280 285 Tyr Cys Val Lys Thr Gln Gln Ile Arg Glu Lys Val Trp Gly Lys Leu 290 295 300

Cys Leu Lys 305 <210> 3287 <211> 938 <212> DNA <213> Felis catus <400> 3287

caacaaaagg catgggccac acgatctcgg atctgtttgg tcttcacact atagactatg 60 gggttcatca ggggaggggc tagaaggtac acaaagccca tgatcacttg gacaagatga 120 ggtgccttgt tcccaaaccg gtggatgatg gacaaaccaa tcatgggagt gtagaagagg 180 agcacagcac atatatggga aacacacgtg ttgagagctt tgaatctctc agccctggat 240 gcaatagaca gcacagtacg caggatcagg gcataggaga agagaatgag cagtgagtct 300 acacccactg ttgaaacaat gacaaacatg ccatagatgc tgttggcttt gatgtctgca 360 caggccaatt tcattacttc ttgatggaga caataggaat gtgagagaag tgcagagcca 420 caataggaga atcttttgag cataaaaggc aatgggaaaa tgagtgctac actgcgaccc 480 agggaaacca ggccaatcct gccaatgact gtgttggtga gaatggaagc atagtgcaag 540 gggcgacaaa tggccacaaa gcggtcaaag gccatagaca gcagcacaga ggactctagg 600 aaggacaaac agtgaatgaa aaagagctgg gcaaaacagg catcgtgacc aatatctcgc 660

Page 3675

069269_0225_SL.TXT gccccaatcc aaaagatgcc tagcactgta gggagggtgc aaagagacag acccaggtca gtcacagcca gcatggacag gaagaggtac ataggctcat ggagtgaggg ctctgtttta atgataaaaa ggatagtaca gttgcccagg atggaaacca ggtaaatgaa gcacaatggg atggagatcc agatgtgcat gtgctccagc ccaggaatgc cactcagcag aaaggtggag gaaatgttgc tgctgctttc caagggtccc aaagacat

720

780

840

900

938 <210> 3288 <211> 313 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (313)..(313) <223> Any amino acid <400> 3288

Met Ser Leu Gly Pro Leu Glu Ser Ser Ser Asn Ile Ser Ser Thr Phe 1 5 10 15 Leu Leu Ser Gly Ile Pro Gly Leu Glu His Met His Ile Trp Ile Ser 20 25 30 Ile Pro Leu Cys Phe Ile Tyr Leu Val Ser Ile Leu Gly Asn Cys Thr 35 40 45 Ile Leu Phe Ile Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr 50 55 60 Leu Phe Leu Ser Met Leu Ala Val Thr Asp Leu Gly Leu Ser Leu Cys 65 70 75 80 Thr Leu Pro Thr Val Leu Gly Ile Phe Trp Ile Gly Ala Arg Asp Ile 85 90 95 Gly His Asp Ala Cys Phe Ala Gln Leu Phe Phe Ile His Cys Leu Ser 100 105 110 Phe Leu Glu Ser Ser Val Leu Leu Ser Met Ala Phe Asp Arg Phe Val

Page 3676

069269_0225_SL.TXT

115 120 125 Ala Ile Cys Arg Pro Leu His Tyr Ala Ser Ile Leu Thr Asn Thr Val 130 135 140 Ile Gly Arg Ile Gly Leu Val Ser Leu Gly Arg Ser Val Ala Leu Ile 145 150 155 160 Phe Pro Leu Pro Phe Met Leu Lys Arg Phe Ser Tyr Cys Gly Ser Ala 165 170 175 Leu Leu Ser His Ser Tyr Cys Leu His Gln Glu Val Met Lys Leu Ala 180 185 190 Cys Ala Asp Ile Lys Ala Asn Ser Ile Tyr Gly Met Phe Val Ile Val 195 200 205 Ser Thr Val Gly Val Asp Ser Leu Leu Ile Leu Phe Ser Tyr Ala Leu 210 215 220 Ile Leu Arg Thr Val Leu Ser Ile Ala Ser Arg Ala Glu Arg Phe Lys 225 230 235 240 Ala Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Leu Phe Tyr 245 250 255 Thr Pro Met Ile Gly Leu Ser Ile Ile His Arg Phe Gly Asn Lys Ala 260 265 270 Pro His Leu Val Gln Val Ile Met Gly Phe Val Tyr Leu Leu Ala Pro 275 280 285 Pro Leu Met Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile Arg 290 295 300 Asp Arg Val Ala His Ala Phe Cys Xaa

305 310 <210> 3289

Page 3677

069269_0225_SL.TXT <211> 960 <212> DNA <213> Felis catus <400> 3289

ctatcgaaaa cacttaaggg attttacaat ctcaagcttc ttagcaatgc ggatacggat 60 ttgcttggtc ttcatactgt agacaatggg gttcatgaga ggtgggacca gcagatacac 120 ataagacatg aggaggtgta caatacgggg cagatgttca ccaaagcggt gcacgagaga 180 caagccaatc atggggatgt agaagagtag cacagcacag atatgagaga cgcaggtgtt 240 gagggcctga agtcgctcct ggcgggaggc aatgcttagc acagtgcgga ggatgagggc 300 ataggagagg aagatgagca gtgaatccac accaacagtg aaggccacaa caaagagccc 360 atatatgtga ttgacaatga tgctagagca ggccaacttc atgatctcta ggtgcagaca 420 ataggcatgg gccagcacat gggagccgca gtactggaag cgtttaagga ggaatggcag 480 gggcaggatg agcagggcac ttctaagaat tgagctcagc cccatcttga tgatacgtgc 540 aggtgtcaag accatggagt aacgcaatgg attgcaaatg gccacatagc ggtcaatgga 600 catggacagt agaactgaag actctaccag tgacaaggta tggatgaaga agagctgagt 660 gaagcaggcg gggatggtaa tctctctgac atcaaaccag aagatgccca acacagtggg 720 cagtgtagat aggcaaaggc ccaagtctgt cagggccagc atggccaaga aatagtacat 780 gggttcatgg agggtgacgt cggtatggat gatgtggagg atggtaaggt ttcctacaat 840 aactgtcaag tagatggagc agaagggaat agagatccag ccatggagag cttccagacc 900 ttggaagcct gttaggaaga aagtggctct ttggaggctg ccattataaa atattgtcat 960

<210> 3290 <211> 319 <212> PRT <213> Felis catus <400> 3290

Met Thr Ile Phe Tyr Asn Gly Ser Leu Gln Arg Ala Thr Phe Phe Leu 1 5 10 15 Thr Gly Phe Gln Gly Leu Glu Ala Leu His Gly Trp Ile Ser Ile Pro

20 25 30

Page 3678

Phe Cys Ser 35 Ile Tyr Leu Thr 069269_0225_SL.TXT Val Ile Val Gly Asn Leu 40 45 Thr Ile Leu His Ile Ile His Thr Asp Val Thr Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Gly Leu Cys Leu Ser Thr Leu 65 70 75 80 Pro Thr Val Leu Gly Ile Phe Trp Phe Asp Val Arg Glu Ile Thr Ile 85 90 95 Pro Ala Cys Phe Thr Gln Leu Phe Phe Ile His Thr Leu Ser Leu Val 100 105 110 Glu Ser Ser Val Leu Leu Ser Met Ser Ile Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ser Met Val Leu Thr Pro Ala Arg Ile Ile 130 135 140 Lys Met Gly Leu Ser Ser Ile Leu Arg Ser Ala Leu Leu Ile Leu Pro 145 150 155 160 Leu Pro Phe Leu Leu Lys Arg Phe Gln Tyr Cys Gly Ser His Val Leu 165 170 175 Ala His Ala Tyr Cys Leu His Leu Glu Ile Met Lys Leu Ala Cys Ser 180 185 190 Ser Ile Ile Val Asn His Ile Tyr Gly Leu Phe Val Val Ala Phe Thr 195 200 205 Val Gly Val Asp Ser Leu Leu Ile Phe Leu Ser Tyr Ala Leu Ile Leu 210 215 220 Arg Thr Val Leu Ser Ile Ala Ser Arg Gln Glu Arg Leu Gln Ala Leu 225 230 235 240

Page 3679

Asn Thr Cys Val Ser 245 His Ile 069269_0225_SL.TXT Cys Ala Val Leu Leu Phe 250 Tyr Ile 255 Pro Met Ile Gly Leu Ser Leu Val His Arg Phe Gly Glu His Leu Pro Arg 260 265 270 Ile Val His Leu Leu Met Ser Tyr Val Tyr Leu Leu Val Pro Pro Leu 275 280 285 Met Asn Pro Ile Val Tyr Ser Met Lys Thr Lys Gln Ile Arg Ile Arg 290 295 300 Ile Ala Lys Lys Leu Glu Ile Val Lys Ser Leu Lys Cys Phe Arg

305 310 315 <210> 3291 <211> 942 <212> DNA <213> Felis catus <400> 3291

ttacatctgc ttctgacata attttgctac aactcttact ctaatctgtc tcgttttcac 60 acagtacaca atgggattca tcattggagg cacaagtaaa agaacatttg ccatgagaac 120 attgaagaga ggggagacat gtcggacaaa ccgatggaca atggaaaggt taatgatggg 180 cagatagaag atgatcactg cacagatgtg tgaaacacaa gtattgaggg ccttgagctg 240 ctcctttcgg gatgcaattc ccagcacagt cttgaggatc aggaagtaag acacagcaat 300 aagcataaag tctaccataa cccacagtac tccaaaaaag ccatatatga catcaattcg 360 gttgtcagag caggccaact tcatgacatc ctggtggaga cagtaggaat gggataattg 420 gcttttatta caatatttca aacttctcaa agtgaagggg aagggtagca ctaggaggac 480 actcttaagg gatatcacta ttcctatttt gacaactctg ataggagtaa gaatggatct 540 gtatctcaga gggctgtgga tggctaggaa gcggtcaaac gacatgatca agagcactga 600 agattccact gctgcaaatc catggatgaa gaattcttgg gcaaagcagg cattggcaga 660 aatttcaggg gcattgaata agaagatcct ccacatggtg ggtagagaag agaaggacag 720 gcccatgtca gacatggcta acatggaaag gaagtagtac atgggctcat gcaaagaggg 780

Page 3680

069269_0225_SL.TXT ctctgtcttg atgaccaaaa ggatggtgca gtttcccaga atagcaaaaa tatacatgct acatatgggg atagagatcc agatgtgtgc atattccagc cctggcatcc caaccaagaa gaaggtggtg atttcaacat ctgatgtatt aataatggac at

840

900

942 <210> 3292 <211> 313 <212> PRT <213> Felis catus

<400> 3292 Thr Ser Asp Val Glu Ile Thr Thr Phe Phe Leu Met Ser 1 Ile Ile Asn 5 10 15 Val Gly Met Pro Gly Leu Glu Tyr Ala His Ile Trp Ile Ser Ile Pro 20 25 30 Ile Cys Ser Met Tyr Ile Phe Ala Ile Leu Gly Asn Cys Thr Ile Leu 35 40 45 Leu Val Ile Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ala Met Ser Asp Met Gly Leu Ser Phe Ser Ser Leu 65 70 75 80 Pro Thr Met Trp Arg Ile Phe Leu Phe Asn Ala Pro Glu Ile Ser Ala 85 90 95 Asn Ala Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Ala Ala Val 100 105 110 Glu Ser Ser Val Leu Leu Ile Met Ser Phe Asp Arg Phe Leu Ala Ile 115 120 125 His Ser Pro Leu Arg Tyr Arg Ser Ile Leu Thr Pro Ile Arg Val Val 130 135 140 Lys Ile Gly Ile Val Ile Ser Leu Lys Ser Val Leu Leu Val Leu Pro 145 150 155 160

Page 3681

069269_0225_SL.TXT

Phe Pro Phe Thr Leu Arg Ser Leu Lys Tyr Cys Asn Lys Ser Gln Leu 165 170 175 Ser His Ser Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ser 180 185 190 Asp Asn Arg Ile Asp Val Ile Tyr Gly Phe Phe Gly Val Leu Trp Val 195 200 205 Met Val Asp Phe Met Leu Ile Ala Val Ser Tyr Phe Leu Ile Leu Lys 210 215 220 Thr Val Leu Gly Ile Ala Ser Arg Lys Glu Gln Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Val Ser His Ile Cys Ala Val Ile Ile Phe Tyr Leu Pro Ile 245 250 255 Ile Asn Leu Ser Ile Val His Arg Phe Val Arg His Val Ser Pro Leu 260 265 270 Phe Asn Val Leu Met Ala Asn Val Leu Leu Leu Val Pro Pro Met Met 275 280 285 Asn Pro Ile Val Tyr Cys Val Lys Thr Arg Gln Ile Arg Val Arg Val 290 295 300 Val Ala Lys Leu Cys Gln Lys Gln Met 305 310 <210> 3293 <211> 930 <212> DNA <213> Felis catus <400> 3293 tcaaccttgt tatcacatag ttttgccagg atccgatttc taatctgctg actcatcact gagtacacaa tgggattcat tagagggtac cagaaggaaa atatcagcta taatggccct aatgactggg gaaacatttt ttggcaaagc gatgaagggc ggccaaggca catagaagat

120

180

Page 3682

069269_0225_SL.TXT gaacacagca cagatgtggg agatgcaggt gttgagaacc ttgaggcggc ccttgtgtga ggcaatgcct agaataagtt tcaagatcaa catgtaagac acagaaatgc accccaagta caataaggat gtaagagcca caaagagtcc atagataaca ttgaccctgt tgtcagaaca ggccagcttc atgacattca ggtggaggca gtaggagtgg gatagaaggc ttttcctaca gaatttcagc ctctttagaa taaaggggaa agggaggaca aacatgatac ataatgcagc aaatatgagg ccgattttaa agactctggc actggtcagg atggaggtgt atctcagaga gctgtagatg gctatgaagt gatctatgga catgatgaga agaactgatg actctatagc tgagaatcca tgaatgaaaa actcttgggc aaagcagccc ttgggggaaa ttccagtggc attgaacaag aagattctca gcatggttgg aagggaggag atggaaagtc ccaggtcaga aaaggccagc atggagagaa aataatacat tggggcatgc agagaggtct ctgtttttat gaaaaagagg acagtgcagt tccccaggat ggcaaggagg tacatgaggc aaatggggat caagacccaa atgtgagcat gctccatgcc tgggatccca atgaggaaga aggtagagat ttccatttca gaggtgttca agactgacat <210> 3294 <211> 296 <212> PRT <213> Felis catus

240

300

360

420

480

540

600

660

720

780

840

900

930

<400> 3294 Met Ser Val Leu 1 Asn 5 Thr Ser Glu Met Glu Ile Ser Thr Phe Phe Leu 10 15 Ile Gly Ile Pro Gly Met Glu His Ala His Ile Trp Val Leu Ile Pro 20 25 30 Ile Cys Leu Met Tyr Leu Leu Ala Ile Leu Gly Asn Cys Thr Val Leu 35 40 45 Phe Phe Ile Lys Thr Glu Thr Ser Leu His Ala Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Met Leu Ala Phe Ser Asp Leu Gly Leu Ser Ile Ser Ser Leu 65 70 75 80

Page 3683

069269_0225_SL.TXT

Pro Thr Met Leu Arg Ile Phe Leu Phe Asn Ala Thr Gly Ile Ser Pro 85 90 95 Lys Gly Cys Phe Ala Gln Glu Phe Phe Ile His Gly Phe Ser Ala Ile 100 105 110 Glu Ser Ser Val Leu Leu Ile Met Ser Ile Asp His Phe Ile Ala Ile 115 120 125 Tyr Ser Ser Leu Arg Tyr Thr Ser Ile Leu Thr Ser Ala Arg Val Phe 130 135 140 Lys Ile Gly Leu Ile Phe Ala Ala Leu Cys Ile Met Phe Val Leu Pro 145 150 155 160 Phe Pro Phe Ile Leu Lys Arg Leu Lys Phe Cys Arg Lys Ser Leu Leu 165 170 175 Ser His Ser Tyr Cys Leu His Leu Asn Val Met Lys Leu Ala Cys Ser 180 185 190 Asp Asn Arg Val Asn Val Ile Tyr Gly Leu Phe Val Ala Leu Thr Ser 195 200 205 Leu Leu Tyr Leu Gly Cys Ile Ser Val Ser Tyr Met Leu Ile Leu Lys 210 215 220 Leu Ile Leu Gly Ile Ala Ser His Lys Gly Arg Leu Lys Val Leu Asn 225 230 235 240 Thr Cys Ile Ser His Ile Cys Ala Val Phe Ile Phe Tyr Val Pro Trp 245 250 255 Pro Pro Phe Ile Ala Leu Pro Lys Asn Val Ser Pro Val Ile Arg Ala 260 265 270 Ile Ile Ala Asp Ile Phe Leu Leu Val Pro Ser Asn Glu Ser His Cys 275 280 285

Page 3684

069269_0225_SL.TXT

Val Leu Ser Asp Glu Ser Ala Asp 290 295 <210> 3295 <211> 659 <212> DNA <213> Felis catus <400> 3295

ctgacacagc ttccctaaaa ccatatttct tatctgttgg ctcttcacac agtatacaat 60 gggattcatc aatggaggta ccaacaggaa aacatcagcc atgaagatcc taactattgg 120 ggagctgtgt ttggcaaacc ggtagataac agttagagag aaaatgggaa catagaagat 180 gagcacagca cagatgtggg acacgcaggt gttgaggacc ttgagccttt gtttctgtga 240 tgctatgctc aatactgctt tcagtatcat catataggac atgaaaataa atcctaagtc 300 tagggtgcct gtgacagcca caaataagcc atagatgaca ttgaccttgt tgtcagagca 360 ggccagcttc atgacatcct gatggaggca gtaggaatgg gaaaggaggg tcttcttaca 420 gtatcttaga tgttttaggg tcaaagggaa agggaggatc aacagaacat ttttgaaaga 480 aaaagcaagc ccaattttgg tgactctggc actggtcagg atggaagtgt atctcagagg 540 gttgcagatg gcaataaatc gatcaaagga catgatgaga agaactgatg attccatagc 600 tgagaatcca tgaataaaaa attcttgggc aaagcaggca tcaggggaaa ttcctggag 659

<210> 3296 <211> 219 <212> PRT <213> Felis catus

<400> 3296 Asp Ala Cys Phe Ala Gln Glu Phe Phe Ile His Pro 1 Gly Ile Ser Pro 5 10 15 Gly Phe Ser Ala Met Glu Ser Ser Val Leu Leu Ile Met Ser Phe Asp 20 25 30 Arg Phe Ile Ala Ile Cys Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr 35 40 45

Page 3685

069269_0225_SL.TXT

Ser Ala 50 Arg Val Thr Lys Ile Gly Leu Ala Phe Ser Phe Lys Asn Val 55 60 Leu Leu Ile Leu Pro Phe Pro Leu Thr Leu Lys His Leu Arg Tyr Cys 65 70 75 80 Lys Lys Thr Leu Leu Ser His Ser Tyr Cys Leu His Gln Asp Val Met 85 90 95 Lys Leu Ala Cys Ser Asp Asn Lys Val Asn Val Ile Tyr Gly Leu Phe 100 105 110 Val Ala Val Thr Gly Thr Leu Asp Leu Gly Phe Ile Phe Met Ser Tyr 115 120 125 Met Met Ile Leu Lys Ala Val Leu Ser Ile Ala Ser Gln Lys Gln Arg 130 135 140 Leu Lys Val Leu Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Ile 145 150 155 160 Phe Tyr Val Pro Ile Phe Ser Leu Thr Val Ile Tyr Arg Phe Ala Lys 165 170 175 His Ser Ser Pro Ile Val Arg Ile Phe Met Ala Asp Val Phe Leu Leu 180 185 190 Val Pro Pro Leu Met Asn Pro Ile Val Tyr Cys Val Lys Ser Gln Gln 195 200 205 Ile Arg Asn Met Val Leu Gly Lys Leu Cys Gln

210 215 <210> 3297 <211> 875 <212> DNA <213> Felis catus <400> 3297 acacagtata caatgggatt catcaatgga ggtaccaaca ggaaaacatc agccatgaag

Page 3686

069269_0225_SL.TXT atcctaacta ttggggagct gtgtttggca aaccggtaga taacagttag agagaaaatg ggaacataga agatgagcac agcacagatg tgggacacgc aggtgttgag gaccttgagc ctttgtttct gtgatgctat gctcaatact gctttcagta tcatcatata ggacatgaaa ataaatccta agtctagggt gcctgtgaca gccacaaata agccatagat gacattgacc ttgttgtcag agcaggccag cttcatgaca tcctgatgga ggcagtagga atgggaaagg agggtcttct tacagtatct tagatgtttt agggtcaaag ggaaagggag gatcaacaga acatttttga aagaaaaagc aagcccaatt ttggtgactc tggcactggt caggatggaa gtgtatctca gagggttgca gatggcaata aatcgatcaa aggacatgat gagaagaact gatgattcca tagctgagaa tccatgaata aaaaattctt gggcaaagca ggcatcaggg gaaattcctg gagcattgaa caagaatatc cttagcatgg tagggagaga tgagagggac agtcctaggt cagagagagc caacatggag agaaaatagt acatgggttc gtgcagagat ggttctgttt ttatgaaaaa cagaatggta cagttcccca ggatggcaat gaggtacatg aagcaaatag gtatggagac ccaaatgtgg gcatgctcca tccctgggat cccaatcagg aagaaggtag aaattttcag tttcagagct gttga <210> 3298 <211> 292 <212> PRT <213> Felis catus

120

180

240

300

360

420

480

540

600

660

720

780

840

875 <400> 3298

Ser Thr Ala Leu Lys Leu Lys Ile Ser Thr Phe Phe Leu Ile Gly Ile 1 5 10 15 Pro Gly Met Glu His Ala His Ile Trp Val Ser Ile Pro Ile Cys Phe 20 25 30 Met Tyr Leu Ile Ala Ile Leu Gly Asn Cys Thr Ile Leu Phe Phe Ile 35 40 45 Lys Thr Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ser Met 50 55 60

Page 3687

069269_0225_SL.TXT

Leu 65 Ala Leu Ser Asp Leu Gly Leu Ser Leu Ser Ser Leu Pro Thr Met 70 75 80 Leu Arg Ile Phe Leu Phe Asn Ala Pro Gly Ile Ser Pro Asp Ala Cys 85 90 95 Phe Ala Gln Glu Phe Phe Ile His Gly Phe Ser Ala Met Glu Ser Ser 100 105 110 Val Leu Leu Ile Met Ser Phe Asp Arg Phe Ile Ala Ile Cys Asn Pro 115 120 125 Leu Arg Tyr Thr Ser Ile Leu Thr Ser Ala Arg Val Thr Lys Ile Gly 130 135 140 Leu Ala Phe Ser Phe Lys Asn Val Leu Leu Ile Leu Pro Phe Pro Leu 145 150 155 160 Thr Leu Lys His Leu Arg Tyr Cys Lys Lys Thr Leu Leu Ser His Ser 165 170 175 Tyr Cys Leu His Gln Asp Val Met Lys Leu Ala Cys Ser Asp Asn Lys 180 185 190 Val Asn Val Ile Tyr Gly Leu Phe Val Ala Val Thr Gly Thr Leu Asp 195 200 205 Leu Gly Phe Ile Phe Met Ser Tyr Met Met Ile Leu Lys Ala Val Leu 210 215 220 Ser Ile Ala Ser Gln Lys Gln Arg Leu Lys Val Leu Asn Thr Cys Val 225 230 235 240 Ser His Ile Cys Ala Val Leu Ile Phe Tyr Val Pro Ile Phe Ser Leu 245 250 255 Thr Val Ile Tyr Arg Phe Ala Lys His Ser Ser Pro Ile Val Arg Ile 260 265 270

Page 3688

069269_0225_SL.TXT

Phe Met Ala Asp Val Phe Leu Leu Val Pro Pro Leu Met Asn Pro Ile 275 280 285

Val Tyr Cys Val 290 <210> 3299 <211> 963 <212> DNA <213> Felis catus <400> 3299

atgccaaggt tcaccatggt ggtctggaat aacaataaca ccatggagcc tatatttatt 60 ctgaggggat ttcatggatt ggagtgtgtc tattcttgga tctcagtccc attctgtctt 120 gcatacttgg tagcatttat tggtaatgtt accatcctct ctgtcatttg gatagagtca 180 tcactccatc agcccatgta ctacttcctt tccatcttgg cactgactga cctaggtatg 240 tctatgtcca cacttcccac catgcttgct gtgttatggc tggatgctcg ggagatccag 300 gcaagtgctt gctatgctca gctctttttc atccacacat tcacattcct ggagtcttcg 360 gtgctactgg ccatggcctt tgaccgtttt gttgctatct gccgtccact gcactatact 420 accatcctta acaacagtgt aataggcaag attggtttgg cctgcttgct aagaagcatg 480 ggagttgtac ttcctacacc tttgctactg agacattatc actactgcca tgacaatgcc 540 ctttcccata ccttctgttt gcaccaagac attctgaaat tatcctgttc agatgcaagg 600 atcagcagtg tctatggcct gtgtgtagtt attaccacac ttggtgtgga ttcagtctgc 660 atacttcttt cttatatcct gattctgaat gctgtgctgg ggattgcatc tcatgaagag 720 cggcggaagg cactcaacac atgcatatcc catatctgtg ttgtgctcat tttctttgtg 780 ccagtaattg gggtgtcaat ggtccatcgc tttgggaaac atctgtctcc aagaattcac 840 atcatcatgg ccgatattta cctgcttttc cccccagtgc ttaaccctat tgtctatagc 900 atcaaaacaa agcagattcg tctaagaatt ctccgcaggt ttggactgcg gagggggcat 960

taa 963 <210> 3300 <211> 320 <212> PRT

Page 3689

069269_0225_SL.TXT <213> Felis catus <400> 3300

Met Pro Arg Phe Thr Met Val Val Trp Asn Asn Asn Asn Thr Met Glu 1 5 10 15 Pro Ile Phe Ile Leu Arg Gly Phe His Gly Leu Glu Cys Val Tyr Ser 20 25 30 Trp Ile Ser Val Pro Phe Cys Leu Ala Tyr Leu Val Ala Phe Ile Gly 35 40 45 Asn Val Thr Ile Leu Ser Val Ile Trp Ile Glu Ser Ser Leu His Gln 50 55 60 Pro Met Tyr Tyr Phe Leu Ser Ile Leu Ala Leu Thr Asp Leu Gly Met 65 70 75 80 Ser Met Ser Thr Leu Pro Thr Met Leu Ala Val Leu Trp Leu Asp Ala 85 90 95 Arg Glu Ile Gln Ala Ser Ala Cys Tyr Ala Gln Leu Phe Phe Ile His 100 105 110 Thr Phe Thr Phe Leu Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp 115 120 125 Arg Phe Val Ala Ile Cys Arg Pro Leu His Tyr Thr Thr Ile Leu Asn 130 135 140 Asn Ser Val Ile Gly Lys Ile Gly Leu Ala Cys Leu Leu Arg Ser Met 145 150 155 160 Gly Val Val Leu Pro Thr Pro Leu Leu Leu Arg His Tyr His Tyr Cys 165 170 175 His Asp Asn Ala Leu Ser His Thr Phe Cys Leu His Gln Asp Ile Leu 180 185 190 Lys Leu Ser Cys Ser Asp Ala Arg Ile Ser Ser Val Tyr Gly Leu Cys

Page 3690

195 069269_0225_SL.TXT 200 205 Val Val Ile Thr Thr Leu Gly Val Asp Ser Val Cys Ile Leu Leu Ser 210 215 220 Tyr Ile Leu Ile Leu Asn Ala Val Leu Gly Ile Ala Ser His Glu Glu 225 230 235 240 Arg Arg Lys Ala Leu Asn Thr Cys Ile Ser His Ile Cys Val Val Leu 245 250 255 Ile Phe Phe Val Pro Val Ile Gly Val Ser Met Val His Arg Phe Gly 260 265 270 Lys His Leu Ser Pro Arg Ile His Ile Ile Met Ala Asp Ile Tyr Leu 275 280 285 Leu Phe Pro Pro Val Leu Asn Pro Ile Val Tyr Ser Ile Lys Thr Lys 290 295 300 Gln Ile Arg Leu Arg Ile Leu Arg Arg Phe Gly Leu Arg Arg Gly His 305 310 315 320

<210> 3301 <211> 936 <212> DNA <213> Felis catus <400> 3301

atgtctgtct tcaatagctc tgccctgtac cctcgctttc tcctgacagg cctctcaggc 60 cttgaaagca gatacagctt gatttccatc cccatcttct tggtgtatgc cacctcaatt 120 gcaggaaaca tcaccatcct acttatcatc agaactgagc cttccctcca ccaaccaatg 180 tactactttc tatcaatgct ggcacttact gacctgggcc tatctactac aaccttgcct 240 acgatgttca gcattttctg gttccatgcc cgggagatct cttttaatgc ctgtctcgtc 300 cagatgtact tcattcatgt tttctcgatt attgagtcag ctgtgctgtt ggccatggcc 360 tttgaccgct ttgtagcaat ccgagagccc ctgcgctatg tggccattct aaccaatggt 420 gtgatcactg ggattgggtt ggcaattgct ggaagggcct tggctctggt ctttccggct 480

Page 3691

069269_0225_SL.TXT

tcctttctcc taaagaggct tcaatatcgt tctgtcaata ttctctctta cccattctgc 540 ctgcaccagg accttataaa gacaactgta tccagccgtc aggtcagcag catctatggc 600 ctcatggtgg tcatctgctc catgggactt gattcagtgc tccttctcct ctcctatatc 660 ctcattcttg gcacagtatt gaatatagcc tccaagacgg agagggtgaa agccctcaac 720 acctgcatct cccacatctg tgctgtgctc actttctata caccaatgat tgggctatct 780 atgatccatc gctatgggca gaatgtgtcc ccaattgtcc atgtgctcat ggccaatgtc 840 tacttgctgg tcccacccct catgaacccc attgtctaca gtgtcaagac caagcagatt 900 cgggatagaa tcctcaagaa attcaagcaa cagaaa 936

<210> 3302 <211> 312 <212> PRT <213> Felis catus

<400> 3302 Ser Ser Ala Leu Tyr Pro Arg Phe Leu Leu Thr Met Ser 1 Val Phe Asn 5 10 15 Gly Leu Ser Gly Leu Glu Ser Arg Tyr Ser Leu Ile Ser Ile Pro Ile 20 25 30 Phe Leu Val Tyr Ala Thr Ser Ile Ala Gly Asn Ile Thr Ile Leu Leu 35 40 45 Ile Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Tyr Tyr Phe Leu 50 55 60 Ser Met Leu Ala Leu Thr Asp Leu Gly Leu Ser Thr Thr Thr Leu Pro 65 70 75 80 Thr Met Phe Ser Ile Phe Trp Phe His Ala Arg Glu Ile Ser Phe Asn 85 90 95 Ala Cys Leu Val Gln Met Tyr Phe Ile His Val Phe Ser Ile Ile Glu 100 105 110

Page 3692

Ser Ala Val 115 Leu Leu Ala Met 069269_0225_SL.TXT Ala Phe Asp Arg Phe Val 120 125 Ala Ile Arg Glu Pro Leu Arg Tyr Val Ala Ile Leu Thr Asn Gly Val Ile Thr Gly 130 135 140 Ile Gly Leu Ala Ile Ala Gly Arg Ala Leu Ala Leu Val Phe Pro Ala 145 150 155 160 Ser Phe Leu Leu Lys Arg Leu Gln Tyr Arg Ser Val Asn Ile Leu Ser 165 170 175 Tyr Pro Phe Cys Leu His Gln Asp Leu Ile Lys Thr Thr Val Ser Ser 180 185 190 Arg Gln Val Ser Ser Ile Tyr Gly Leu Met Val Val Ile Cys Ser Met 195 200 205 Gly Leu Asp Ser Val Leu Leu Leu Leu Ser Tyr Ile Leu Ile Leu Gly 210 215 220 Thr Val Leu Asn Ile Ala Ser Lys Thr Glu Arg Val Lys Ala Leu Asn 225 230 235 240 Thr Cys Ile Ser His Ile Cys Ala Val Leu Thr Phe Tyr Thr Pro Met 245 250 255 Ile Gly Leu Ser Met Ile His Arg Tyr Gly Gln Asn Val Ser Pro Ile 260 265 270 Val His Val Leu Met Ala Asn Val Tyr Leu Leu Val Pro Pro Leu Met 275 280 285 Asn Pro Ile Val Tyr Ser Val Lys Thr Lys Gln Ile Arg Asp Arg Ile 290 295 300 Leu Lys Lys Phe Lys Gln Gln Lys

305 310

Page 3693

069269_0225_SL.TXT <210> 3303 <211> 939 <212> DNA <213> Felis catus <400> 3303

atgttttatc ccaacaggag catttttcac ccagacacat tcttcctcgt tggaatccca 60 gggctggaaa gagcccatgc ctggatctcc ctgcctttct gctctgttta ccttgtggct 120 ttgctgggca atgccaccat tttgctagtc atcaagatgg agcagaccct gcggagagag 180 cccatgttct actttctggc cctcctttca actatcgatt tggctctttc cacaacctct 240 atgccccgca tgctgggtat cttctggttt gatgctcatg agattaactt tggggcttgt 300 gtggcccaga tgtttctgat ccatgccttc actggcatgg aggccgaggt cctggtagcc 360 atggcctttg accgttatgt ggcgatctgt gctccactcc actataggac catcttgaca 420 tcccgggtgc tggtgggcat cagcatgtgc attgtgattc gtcctgttct gtttacactt 480 cccatgatct atctcatcta ccgcctaccc ttttgtcagg ctcgtgtaat agctcattcc 540 tactgtgaac acatgggcat tgcaaaactg tcctgtggaa acatccgtat caatgccatc 600 tatgggctct ttgtggtgtc tctctttctt ctgaacctgt tccttattgg catctcctat 660 gtttacatac tccgagctgt tttccgcctc ccatcacacg atgctcggtt aaaagcccta 720 agcacgtgtg gctctcacgt tggggtcatc tgcgttttct atatcccctc agtgttctcc 780 ttcctcactc accgatttgg acacaacata ccacgctaca ttcacattct tgttgccaac 840 ctctatttgg ttatcccacc ttcgctcaac cccatcattt atggtgtaag gaccaaacag 900 atacgagagc gagtgctctg tgtctttgct aaaaagtag 939

<210> 3304 <211> 312 <212> PRT <213> Felis catus <400> 3304

Met Phe Tyr Pro Asn Arg Ser Ile Phe His Pro Asp Thr Phe Phe Leu

1 5 10 15

Val Gly Ile Pro Gly Leu Glu Arg Ala His Ala Trp Ile Ser Leu Pro

20 25 30

Page 3694

069269_0225_SL.TXT

Phe Cys Ser 35 Val Tyr Leu Val Ala Leu Leu Gly Asn Ala Thr Ile Leu 40 45 Leu Val Ile Lys Met Glu Gln Thr Leu Arg Arg Glu Pro Met Phe Tyr 50 55 60 Phe Leu Ala Leu Leu Ser Thr Ile Asp Leu Ala Leu Ser Thr Thr Ser 65 70 75 80 Met Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Glu Ile Asn 85 90 95 Phe Gly Ala Cys Val Ala Gln Met Phe Leu Ile His Ala Phe Thr Gly 100 105 110 Met Glu Ala Glu Val Leu Val Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 Ile Cys Ala Pro Leu His Tyr Arg Thr Ile Leu Thr Ser Arg Val Leu 130 135 140 Val Gly Ile Ser Met Cys Ile Val Ile Arg Pro Val Leu Phe Thr Leu 145 150 155 160 Pro Met Ile Tyr Leu Ile Tyr Arg Leu Pro Phe Cys Gln Ala Arg Val 165 170 175 Ile Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ser Cys 180 185 190 Gly Asn Ile Arg Ile Asn Ala Ile Tyr Gly Leu Phe Val Val Ser Leu 195 200 205 Phe Leu Leu Asn Leu Phe Leu Ile Gly Ile Ser Tyr Val Tyr Ile Leu 210 215 220 Arg Ala Val Phe Arg Leu Pro Ser His Asp Ala Arg Leu Lys Ala Leu 225 230 235 240

Page 3695

069269_0225_SL.TXT

Ser Thr Cys Gly Ser His Val Gly Val Ile Cys Val Phe Tyr Ile Pro 245 250 255 Ser Val Phe Ser Phe Leu Thr His Arg Phe Gly His Asn Ile Pro Arg 260 265 270 Tyr Ile His Ile Leu Val Ala Asn Leu Tyr Leu Val Ile Pro Pro Ser 275 280 285 Leu Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg 290 295 300 Val Leu Cys Val Phe Ala Lys Lys

305 310 <210> 3305 <211> 934 <212> DNA <213> Felis catus <400> 3305

gtttctttaa tattattttc ttcacacggt cataaatctg tttggttctg actccgtaga 60 tgacagggtt gagcattggt ggcactacga cataaagatt ggccaggagt atgtggatat 120 agcgggggac gttatggcca aagcgatgtg tcataaagga aaagagggct ggtgtataga 180 aggcaagaat tacacaaaca tgagaaccac aagtgctgag ggacttgagt cgggcttcac 240 gggaaggaag acggaaaacg gcacggagta tctgaacata agaaagggca atggctatga 300 tgtcaaatac tagattacaa attgcacata agccataaat aatattgatc ttgatgctgg 360 cacaagacag acgagccaga cccatgtgtt cacagtaggt atggggaatg acatgattcc 420 cacagaaggg cagtcgcaaa ataagaaaca caaatggaat cacaaaaata aatgccctca 480 ctaacacacc aacaccaatc acagagacaa tcttgttggt gaggacggtg ctgtatcgaa 540 gcggatcgca gatggccaca tagcggtcat aagccattgc caacaagact gctgactcca 600 taagtgtgaa gctgtgaatg aaaaacatct gcatgaggca ggcttcaaag atgatctctc 660 tgaggttgaa ccagaagatc ccgagcatct tggggatggt agctgtggac agacccaaat 720 caatagcagc caacatggtc aggaagtaaa acataggctg gtgtaggctg ctctcaaccc 780

Page 3696

069269_0225_SL.TXT agatcacaaa taggatagtg aagttcccca tgagggcaat catgtacaca gcacaaaaag gaaagccaat ccagacatgc aatgtttcca accctggaat ccccagcaac aagaaggaga cgaggtggaa ctgggtgtca ttgagaagga acat

840

900

934 <210> 3306 <211> 312 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (312)..(312) <223> Any amino acid <400> 3306

Met Phe 1 Leu Leu Asn Asp Thr Gln Phe His Leu Val Ser Phe Leu 15 Leu 5 10 Leu Gly Ile Pro Gly Leu Glu Thr Leu His Val Trp Ile Gly Phe Pro 20 25 30 Phe Cys Ala Val Tyr Met Ile Ala Leu Met Gly Asn Phe Thr Ile Leu 35 40 45 Phe Val Ile Trp Val Glu Ser Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Thr Met Leu Ala Ala Ile Asp Leu Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Arg Glu Ile Ile Phe 85 90 95 Glu Ala Cys Leu Met Gln Met Phe Phe Ile His Ser Phe Thr Leu Met 100 105 110 Glu Ser Ala Val Leu Leu Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125

Page 3697

Cys Asp 130 Pro Leu Arg Tyr Ser 135 069269_0225_SL.TXT Thr Val Leu Thr Asn Lys 140 Ile Val Ser Val Ile Gly Val Gly Val Leu Val Arg Ala Phe Ile Phe Val Ile Pro 145 150 155 160 Phe Val Phe Leu Ile Leu Arg Leu Pro Phe Cys Gly Asn His Val Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Leu Ala Arg Leu Ser Cys Ala 180 185 190 Ser Ile Lys Ile Asn Ile Ile Tyr Gly Leu Cys Ala Ile Cys Asn Leu 195 200 205 Val Phe Asp Ile Ile Ala Ile Ala Leu Ser Tyr Val Gln Ile Leu Arg 210 215 220 Ala Val Phe Arg Leu Pro Ser Arg Glu Ala Arg Leu Lys Ser Leu Ser 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Ile Leu Ala Phe Tyr Thr Pro Ala 245 250 255 Leu Phe Ser Phe Met Thr His Arg Phe Gly His Asn Val Pro Arg Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Met Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Tyr Asp Arg Val 290 295 300 Lys Lys Ile Ile Leu Lys Lys Xaa 305 310

<210> 3307 <211> 942 <212> DNA <213> Felis catus

Page 3698

069269_0225_SL.TXT

<400> 3307 atggcctcac ttaataacac cctatttcat ccatattctt tcttccttct ggggatccct 60 gggctggaac acatgcatat ctggatgggt ctccctttct ttgctgtgta cctgatagct 120 gttcttggga atatcagcat cctttctgtg attgagactg agagcaccct ccaccagccc 180 atgttctact tcctggccat tctgtcatct atcgacctgg gcctgtccac atccacgatc 240 cccaagatgc ttggaatctt ctggttcagc ctgagagaaa tctcctttga gggatgtctc 300 atccagatgt tcttcatcca tctattcact ggcatggagt cggctgtgct cgtggccatg 360 gcctatgatc gctatgtggc catctgtaac cctcttcggt acacactggt gctgacaaac 420 aaggtggtat tcatcattgc attgataatt ctactgaggc ctttgtcttt tgccataccc 480 tttgttccac tcatcctacg gttaccattt tgtgggcacc aacttatccc tcacacttat 540 tgtgagcaca tgggcattgc ccgcctgtcc tgtgccagca tcagggtcaa catcatctat 600 ggcttatatg ccatctctaa cctggtgttt gacatcatag ccattgtcat ttcttatgcc 660 cagatccttc atgctgtctt tcgactgcct tcccatgatg ctcggctcaa agcgctcagc 720 acctgtggct ctcacgtgtg tgtcatgttg gctttctaca cccctgcgtt tttttcattt 780 atgacccaca ggtttggccg gaatatacca cgttatattc acatccttct ggctaatttc 840 tatgtagtca ttccaccggc tctcaaccct gtaatctatg gtgtcagaac taaacagatt 900 agagaacagg tgctgaaggt attttccaag aaaaaaacat aa 942

<210> 3308 <211> 313 <212> PRT <213> Felis catus <400> 3308

Met 1 Ala Ser Leu Asn Asn Thr Leu Phe His Pro Tyr Ser Phe Phe Leu 5 10 15 Leu Gly Ile Pro Gly Leu Glu His Met His Ile Trp Met Gly Leu Pro 20 25 30 Phe Phe Ala Val Tyr Leu Ile Ala Val Leu Gly Asn Ile Ser Ile Leu 35 40 45

Page 3699

069269_0225_SL.TXT

Ser Val 50 Ile Glu Thr Glu Ser Thr 55 Leu His Gln Pro Met Phe Tyr 60 Phe Leu Ala Ile Leu Ser Ser Ile Asp Leu Gly Leu Ser Thr Ser Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Ser Leu Arg Glu Ile Ser Phe 85 90 95 Glu Gly Cys Leu Ile Gln Met Phe Phe Ile His Leu Phe Thr Gly Met 100 105 110 Glu Ser Ala Val Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Thr Leu Val Leu Thr Asn Lys Val Val Phe 130 135 140 Ile Ile Ala Leu Ile Ile Leu Leu Arg Pro Leu Ser Phe Ala Ile Pro 145 150 155 160 Phe Val Pro Leu Ile Leu Arg Leu Pro Phe Cys Gly His Gln Leu Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ser Cys Ala 180 185 190 Ser Ile Arg Val Asn Ile Ile Tyr Gly Leu Tyr Ala Ile Ser Asn Leu 195 200 205 Val Phe Asp Ile Ile Ala Ile Val Ile Ser Tyr Ala Gln Ile Leu His 210 215 220 Ala Val Phe Arg Leu Pro Ser His Asp Ala Arg Leu Lys Ala Leu Ser 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Met Leu Ala Phe Tyr Thr Pro Ala 245 250 255

Page 3700

069269_0225_SL.TXT

Phe Phe Ser Phe Met Thr His Arg Phe 265 Gly Arg Asn Ile Pro 270 Arg Tyr 260 Ile His Ile Leu Leu Ala Asn Phe Tyr Val Val Ile Pro Pro Ala Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Gln Val 290 295 300 Leu Lys Val Phe Ser Lys Lys Lys Thr 305 310

<210> 3309 <211> 952 <212> DNA <213> Felis catus <400> 3309

ttatttcaca ggctttgaaa aagtgaaaaa tttaagaaac ctgtcccgta tcttcttggt 60 ccttaccccg tagataatag ggttcaccat gggtgggacc agaagataga tgttggccac 120 aaatatgtgg acatggggag ccacatggtg cccaaacctg tgggtaagga aagagaagaa 180 ggctggagta taagacacta agatgacaca gatatgggag ccacaggtac ccaaggtctt 240 gaatcgggca tccttggatg ggaggtggaa gacagtgtgc agtatgagaa cataagaaca 300 aatgatcaat atgaagtcca ggccaccagt aaggaaggca acgatgaggc tgtaggctct 360 acggattctt gtctcagcac aggcaatctt gatgagggcc atgaactcac agtaggtgtg 420 ggaaatgata ttggttctgc agtagggaag ccaacgtagc aggaaggggt gaggactgag 480 aagtgctgtg ccccggagta ctatagctag acccatcccc ccaattacag catgtgtcag 540 aatagctgaa tgtcttaatg ggttacaaat ggctacataa cggtcaaaag ccatggccag 600 aaagaagcca gattccatgg tagagcaaga gtgaatcagg aacacttgag tgaggcaggc 660 ttcaaagcga atctctccat catggaacca gaaaaggcta agaagttttg gtacagctgt 720 agtacacaca accagatcag ccacagccag catgcagagg aagaggtaca ttggctcatg 780 gaggctgggg tctgtcttaa tgataaacag aagagagcag tttcccagga gggccaaaag 840 gtataccaca caaaagggga tggatatcca gatgtgggca gcctccaacc caggaatgcc 900

Page 3701

069269_0225_SL.TXT aatgaggatg aaggttgatg gatggacatc agtcttattg tatgctgaca ta

952 <210> 3310 <211> 316 <212> PRT <213> Felis catus <400> 3310

Met 1 Ser Ala Tyr Asn 5 Lys Thr Asp Val His Pro Ser Thr Phe Ile Leu 10 15 Ile Gly Ile Pro Gly Leu Glu Ala Ala His Ile Trp Ile Ser Ile Pro 20 25 30 Phe Cys Val Val Tyr Leu Leu Ala Leu Leu Gly Asn Cys Ser Leu Leu 35 40 45 Phe Ile Ile Lys Thr Asp Pro Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Cys Met Leu Ala Val Ala Asp Leu Val Val Cys Thr Thr Ala Val 65 70 75 80 Pro Lys Leu Leu Ser Leu Phe Trp Phe His Asp Gly Glu Ile Arg Phe 85 90 95 Glu Ala Cys Leu Thr Gln Val Phe Leu Ile His Ser Cys Ser Thr Met 100 105 110 Glu Ser Gly Phe Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg His Ser Ala Ile Leu Thr His Ala Val Ile Gly 130 135 140 Gly Met Gly Leu Ala Ile Val Leu Arg Gly Thr Ala Leu Leu Ser Pro 145 150 155 160 His Pro Phe Leu Leu Arg Trp Leu Pro Tyr Cys Arg Thr Asn Ile Ile 165 170 175

Page 3702

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Ser His Thr Tyr 180 Cys Glu Phe Met Ala Leu Ile Lys Ile Ala Cys Ala 185 190 Glu Thr Arg Ile Arg Arg Ala Tyr Ser Leu Ile Val Ala Phe Leu Thr 195 200 205 Gly Gly Leu Asp Phe Ile Leu Ile Ile Cys Ser Tyr Val Leu Ile Leu 210 215 220 His Thr Val Phe His Leu Pro Ser Lys Asp Ala Arg Phe Lys Thr Leu 225 230 235 240 Gly Thr Cys Gly Ser His Ile Cys Val Ile Leu Val Ser Tyr Thr Pro 245 250 255 Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly His His Val Ala Pro 260 265 270 His Val His Ile Phe Val Ala Asn Ile Tyr Leu Leu Val Pro Pro Met 275 280 285 Val Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Lys Ile Arg Asp Arg 290 295 300 Phe Leu Lys Phe Phe Thr Phe Ser Lys Pro Val Lys 305 310 315

<210> 3311 <211> 831 <212> DNA <213> Felis catus <400> 3311 atgtcccttc ccaatgacac acagtttcat ccctccttct ttttgctgct ggggatccca ggactggaaa ctgtccacat gtggattggc tttccctttt gcgctgtgta catgattgca ctcataggaa acctcactat tttgtttgtg gtccaggttg acagcagcct acatcagccc atgttctact tcctggccat gttggctagc attgatttgg gtctgtccac agctaccatc

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cccaagatgc ttgggatctt ctggtttggt ctcagggaga taatcttcga tgcttgtctc 300 acccagatgt tttttatcca caacttcact ggtatggagt cagcagtcct gttggcaatg 360 gcttatgacc gctatgtggc catatgcaac ccacttcgat atagcaccat tctcaccaac 420 aaggttgtct ctgtgattgg tgttggtgtg ttagtgaggt catttatttc tgttattcca 480 tttgtgtttc ttattttgcg actgcccttc tgtgggaatc atatcattcc ccatacctat 540 tgtgaacaca tgggtctggc tcgtctgtct tgtgccagca tcaagatcaa tattatttat 600 ggcttatgtg caatttgtaa tctagtattt gacatcatag ccattgccct ttcttatgtt 660 cagatactcc gtgccgtttt ccgtcttcct tcccgtgaag cccgactcaa gtccctcagc 720 acatgtggtt ctcatgtttg tgtaattctt gccttgtata caccagccct ctttttcctt 780 tatgacacat <210> 3312 <211> 267 <212> PRT <213> Felis <400> 3312 cgctttggcc ataaacgtcc catus cccgctatat ccacatactc c 831 Met Ser Leu Pro Asn Asp Thr Gln Phe His Pro Ser Phe Phe Leu Leu 1 5 10 15 Leu Gly Ile Pro Gly Leu Glu Thr 20 Val His Met 25 Trp Ile Gly Phe Pro 30 Phe Cys Ala 35 Val Tyr Met Ile Ala 40 Leu Ile Gly Asn Leu Thr Ile Leu 45 Phe Val Val 50 Gln Val Asp Ser Ser 55 Leu His Gln Pro Met Phe Tyr Phe 60 Leu Ala Met Leu Ala Ser Ile Asp Leu Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp 85 Phe Gly Leu 90 Arg Glu Ile Ile Phe 95 Asp Ala Cys Leu Thr Gln Met Phe Phe Ile His Asn Phe Thr Gly Met

Page 3704

100

069269_0225_SL.TXT 105 110

Glu Ser Ala Val Leu Leu Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn Lys Val Val Ser 130 135 140 Val Ile Gly Val Gly Val Leu Val Arg Ser Phe Ile Ser Val Ile Pro 145 150 155 160 Phe Val Phe Leu Ile Leu Arg Leu Pro Phe Cys Gly Asn His Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Leu Ala Arg Leu Ser Cys Ala 180 185 190 Ser Ile Lys Ile Asn Ile Ile Tyr Gly Leu Cys Ala Ile Cys Asn Leu 195 200 205 Val Phe Asp Ile Ile Ala Ile Ala Leu Ser Tyr Val Gln Ile Leu Arg 210 215 220 Ala Val Phe Arg Leu Pro Ser Arg Glu Ala Arg Leu Lys Ser Leu Ser 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Ile Leu Ala Leu Tyr Thr Pro Ala 245 250 255 Leu Phe Phe Leu Tyr Asp Thr Ser Leu Trp Pro 260 265

<210> 3313 <211> 929 <212> DNA <213> Felis catus <400> 3313 atgttccaca caaacacttc cgctttccac ccagacacct tttttctcac aggcatccca ggatttgagg gtttccatgg ctggatctcc ctaccttttt gctccattta cttaatggct

120

Page 3705

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ctgttaggca atgttacaat tttgctgatc atctggtctg accgtactct gcgggatcct 180 atgttctact ttctagccat cttatcagcc atagatctgg ccctctccac atcgtcagtg 240 ccccgaatgc tgggtatctt ctggtttgat gcacatgaaa ttggttttgg agcctgcgtg 300 gctcagatgt tcctgataca cacctttaca ggaatggagt ctgctgttct gttggccatg 360 gcttttgatc gctatgtggc tatctgtgta ccactccact acacaaccac cctgacaccc 420 cgggtgctag caggcattgg tgtgggcatt ataatgcgtc ctgtcctgct catgttgccc 480 attctatacc taacccatcg tctgcccttt tgtgagactc gaattattgc gcattcctac 540 tgtgagcaca tgggcattgc caagttggcc tgtgccagca ttcgagttaa tgccatttac 600 gggctttttg tggcttcttt tcttattttg gacgtggtac ttgttggaat ctcttatgcc 660 tacatcctcc gtgcagtttt cctcctccca tctcgagatg ctcgtcacaa agccttgagc 720 acatgtgggt cacatgttgg ggtcatgtgt gttttctata caccgtgtct cttctccttc 780 ctcacccacc ggtttggcaa gaaaattccc cattatgttc acatccttgt tgccaatctc 840 tacgttgtat tcccacctgc cctcaatcct attatctacg gtgtgaggac aaagcagatt 900 cgtgagcatg tgatccatgc tctcacctc 929

<210> 3314 <211> 310 <212> PRT <213> Felis catus <400> 3314

Met Phe His Thr Asn Thr Ser Ala Phe His Pro Asp Thr Phe Phe Leu 1 5 10 15 Thr Gly Ile Pro Gly Phe Glu Gly Phe His Gly Trp Ile Ser Leu Pro 20 25 30 Phe Cys Ser Ile Tyr Leu Met Ala Leu Leu Gly Asn Val Thr Ile Leu 35 40 45 Leu Ile Ile Trp Ser Asp Arg Thr Leu Arg Asp Pro Met Phe Tyr Phe 50 55 60

Page 3706

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Leu 65 Ala Ile Leu Ser Ala Ile Asp Leu Ala Leu Ser Thr Ser Ser Val 70 75 80 Pro Arg Met Leu Gly Ile Phe Trp Phe Asp Ala His Glu Ile Gly Phe 85 90 95 Gly Ala Cys Val Ala Gln Met Phe Leu Ile His Thr Phe Thr Gly Met 100 105 110 Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Val Pro Leu His Tyr Thr Thr Thr Leu Thr Pro Arg Val Leu Ala 130 135 140 Gly Ile Gly Val Gly Ile Ile Met Arg Pro Val Leu Leu Met Leu Pro 145 150 155 160 Ile Leu Tyr Leu Thr His Arg Leu Pro Phe Cys Glu Thr Arg Ile Ile 165 170 175 Ala His Ser Tyr Cys Glu His Met Gly Ile Ala Lys Leu Ala Cys Ala 180 185 190 Ser Ile Arg Val Asn Ala Ile Tyr Gly Leu Phe Val Ala Ser Phe Leu 195 200 205 Ile Leu Asp Val Val Leu Val Gly Ile Ser Tyr Ala Tyr Ile Leu Arg 210 215 220 Ala Val Phe Leu Leu Pro Ser Arg Asp Ala Arg His Lys Ala Leu Ser 225 230 235 240 Thr Cys Gly Ser His Val Gly Val Met Cys Val Phe Tyr Thr Pro Cys 245 250 255 Leu Phe Ser Phe Leu Thr His Arg Phe Gly Lys Lys Ile Pro His Tyr 260 265 270

Page 3707

0 69269_02 :25_S L.TX T Val His Ile Leu Val Ala Asn Leu Tyr Val Val Phe Pro Pro Ala Leu 275 280 285 Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu His Val 290 295 300 Ile His Ala Leu Thr Ser 305 310

<210> 3315 <211> 935 <212> DNA <213> Felis catus <400> 3315 atgtcctctg tcaatgacac tgcttcaaat ccctctgcct tccttctgct gggtatacct ggtctggaag ctttccatat ctggattgct ttccctttct ttgttgttta tctgatagca cttgtgggaa atgtcacaat cctggttgtg atcaagactg agcagagtct tcatcaaccc atgttctaat ttttggctct tctctccttt attgatctag gcctttccac ttctaccatt cccaagatgc tatcttctgg ttcaacttca gggagataaa atttgaaggc tgcttcatcc aaatgttctt tatccatacc tacactggca tggaatccgt tgtactgctg gcatggcaac tgactgcctt gttgccatct gttacctact gacatatacc actattctca ccaacagagt ggtagccatc atggcctctg ttgtagtggg gaggccagtc cttcttgtca tccctttctg ccctcttctc aaatggttgc ccttttgtgg atactacatt attcctcaca cctactgtga acacatggga atcgtgcatc tttcctgtgc taacataagg gtcaacatca tctatggctt atataccatt gctgccctga tttctgactt gatccttatt gccctctcct atgttcagat cctacgagct gttttccacc ttccttccag ggatgccaga ctccaaagca cttagcacat gtggctccca tgtctgtgtc atcttagcat tttacacgcc agcatttttc tcttttatga ctcactgatt tggtagtaat attccttgct acatccacat ccttctggcc aatctgtatg tagttgttcc cccttgttta aatccagtca tttatggaac caggacaaag caaattcagg actgagttgt gaaaatactt gtaaataaag aatga <210> 3316

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935

Page 3708

069269_0225_SL.TXT <211> 62 <212> PRT <213> Felis catus

<400> 3316 Asp Thr Ala Ser Asn Pro Ser Ala Phe Leu Leu Met 1 Ser Ser Val Asn 5 10 15 Leu Gly Ile Pro Gly Leu Glu Ala Phe His Ile Trp Ile Ala Phe Pro 20 25 30 Phe Phe Val Val Tyr Leu Ile Ala Leu Val Gly Asn Val Thr Ile Leu 35 40 45 Val Val Ile Lys Thr Glu Gln Ser Leu His Gln Pro Met Phe 50 55 60

<210> 3317 <211> 947 <212> DNA <213> Felis catus <400> 3317

tcagctgatt ttagtcatga ataattgttg aacacattct cggatctgtc tggtccttac 60 tccatagatg agagggttca gcataggtgg taccaacaag tacatgttgg ccagcaggat 120 gtgggtgtgg cgtggtatat gcttactaaa acggtgggtg aggaaggaaa aagagcaggg 180 atgtagaagg tgaggatgac acacacatgg gacccacaag tgctgagggt cttcaacctg 240 gcatcattag aagggagatt aaatacagta cgaagtatct gtacatagga cagagagatg 300 catgtcacat cagtcccaac aattaagaca atgactgcca aactataaag actattgatg 360 gaaatgtcag cacaagccaa tttcaccaca gccatgtgct cacagtatgt gtgggggact 420 acattggact ggcaatatgg ccatctcctt accagaaatg gatgtggtat cattagtact 480 aacccacgta gaagtgccac tatgccaact cgagccacca cagtatttgt aagaatggat 540 gtgtgtctca gcggattgca gattgccaca taccggtcaa gtgccatggc cacaagaagc 600 cctgactcca ccccagagaa agcatggatg aaaaacatct gagtgagaca ggcatggaag 660 ccgatttcat gataattgaa ccagaacata cccaacatct tgggaagagt ggaggttgac 720 aagatgaggt ctgtgatggc caacatggaa agaaaataga acatgggttc atggagaaca 780

Page 3709

069269_0225_SL.TXT gtctcagttt tgatgataaa aaggataagt atgtttccca tgagcgccac aatatacatt gagcagaaag ggatggctat ccaaatatgc aaatattcta ggccaggtat gcccatcagg aagaaggtac taggattggt gaatgcagtg gagttaaagt caatcat

840

900

947 <210> 3318 <211> 289 <212> PRT <213> Felis catus

<400> 3318 Ser Thr Ala Phe Thr Asn Pro Ser Thr Phe Phe Met Ile 1 Asp Phe Asn 5 10 15 Leu Met Gly Ile Pro Gly Leu Glu Tyr Leu His Ile Trp Ile Ala Ile 20 25 30 Pro Phe Cys Ser Met Tyr Ile Val Ala Leu Met Gly Asn Ile Leu Ile 35 40 45 Leu Phe Ile Ile Lys Thr Glu Thr Val Leu His Glu Pro Met Phe Tyr 50 55 60 Phe Leu Ser Met Leu Ala Ile Thr Asp Leu Ile Leu Ser Thr Ser Thr 65 70 75 80 Leu Pro Lys Met Leu Gly Met Phe Trp Phe Asn Tyr His Glu Ile Gly 85 90 95 Phe His Ala Cys Leu Thr Gln Met Phe Phe Ile His Ala Phe Ser Gly 100 105 110 Val Glu Ser Gly Leu Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala 115 120 125 Ile Cys Asn Pro Leu Arg His Thr Ser Ile Leu Thr Asn Thr Val Val 130 135 140 Ala Arg Val Gly Ile Val Ala Leu Leu Arg Gly Leu Val Leu Met Ile 145 150 155 160

Page 3710

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Pro His Pro Phe Leu Val Arg Arg Trp Pro Tyr Cys Gln Ser Asn Val 165 170 175 Val Pro His Thr Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys 180 185 190 Ala Asp Ile Ser Ile Asn Ser Leu Tyr Ser Leu Ala Val Ile Val Leu 195 200 205 Ile Val Gly Thr Asp Val Thr Cys Ile Ser Leu Ser Tyr Val Gln Ile 210 215 220 Leu Arg Thr Val Phe Asn Leu Pro Ser Asn Asp Ala Arg Leu Lys Thr 225 230 235 240 Leu Ser Thr Cys Gly Ser His Val Cys Val Ile Leu Thr Phe Tyr Ile 245 250 255 Pro Ala Leu Phe Pro Ser Ser Pro Thr Val Leu Val Ser Ile Tyr His 260 265 270 Ala Thr Pro Thr Ser Cys Trp Pro Thr Cys Thr Cys Trp Tyr His Leu 275 280 285

Cys <210> 3319 <211> 944 <212> DNA <213> Felis catus <400> 3319 tcaaacacat ttgattatta agaatttaaa gaatccttcc cggattctct tggtttttac accataaata atagggttca tcataggtgg aataagaaga tatatattgg ctataaaaat atggatatgt ggagcgatgt ggtggccaaa cctatgagtg agaaaagaga aaaaggctgg tgtataaaac actaagatga cccatacatg ggagacacat gtacttaagg tcttgaggcg

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Page 3711

069269_0225_SL.TXT ggcagctttc gaaggcagat taaagacagt caatatgaaa tccaatcccc ctgtcaggaa cttggtttca gtgcaaacta gctttatcac gacattcgtt ctgcagtagg aaagccacct agctcctcta aagacaatgc ccaaaccgaa ggaatgtctt aatgggtggc aaatggctat tccagattcc atagtagaca gagaatgaat gtagatctct ctgtaattga accagaagag aagaatcaaa tcagccactg aaagcatgca gtggtctgtc ttgacaatta atagaagggc tagacaaaaa gggatagaaa tccatatgtg tagaaagctg gtagggtgaa gactggtcct <210> 3320 <211> 313 <212> PRT <213> Felis catus gaaaagaata aggacataag aacagatgat tgccacaatt aggctgtagg ctctacgaat agccataaac tcacagtacg tatgggagat cagtagaaag ggatgtggac tgaggagtac gcctataatc actgcagggg tcaggatagt gtagcggtca aaagccatgg ccaggataaa aagatacatt tgagtgaggc aggcttcaaa gctaagtatc ttgggaagtg tagaagaagt tagaaagagg tacataggtt cgtgtagttt aacatttccc attagtgaca cgaggtagac aacagcctcc aatcctggaa tgccaagcag gttgtaattt aaca

300

360

420

480

540

600

660

720

780

840

900

944

<400> 3320 Leu 1 Asn Tyr Asn Arg 5 Thr Ser Leu Gly Ile Pro Gly 20 Leu Glu Ala Val Cys Leu Val 35 Tyr Leu Val Ser Leu 40 Ile Val 50 Lys Thr Asp His Lys 55 Leu Cys 65 Met Leu Ser Val Ala 70 Asp Leu Lys Ile Leu Ser Leu Phe Trp Phe

His Pro 10 Thr Ser Phe Leu Leu 15 Leu His 25 Ile Trp Ile Ser Ile 30 Pro Phe Met Gly Asn Val Ala 45 Leu Leu Leu His Glu Pro Met 60 Tyr Leu Phe Leu Ile Leu Thr 75 Ser Ser Thr Leu Pro 80 Asn 1 Tyr Page Arg Glu 3712 Ile Tyr Phe Glu

069269_0225_SL.TXT

85 90 95

Ala Cys Leu Thr 100 Gln Met Tyr Leu Ile His Ser Leu Ser Thr Met Glu 105 110 Ser Gly Phe Ile Leu Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile Cys 115 120 125 His Pro Leu Arg His Ser Thr Ile Leu Thr Pro Ala Val Ile Ile Gly 130 135 140 Phe Gly Leu Gly Ile Val Phe Arg Gly Ala Val Leu Leu Ser Pro His 145 150 155 160 Pro Phe Leu Leu Arg Trp Leu Ser Tyr Cys Arg Thr Asn Val Ile Ser 165 170 175 His Thr Tyr Cys Glu Phe Met Ala Val Ile Lys Leu Val Cys Thr Glu 180 185 190 Thr Lys Ile Arg Arg Ala Tyr Ser Leu Ile Val Ala Phe Leu Thr Gly 195 200 205 Gly Leu Asp Phe Ile Leu Ile Ile Cys Ser Tyr Val Leu Ile Leu Phe 210 215 220 Thr Val Phe Asn Leu Pro Ser Lys Ala Ala Arg Leu Lys Thr Leu Ser 225 230 235 240 Thr Cys Val Ser His Val Trp Val Ile Leu Val Phe Tyr Thr Pro Ala 245 250 255 Phe Phe Ser Phe Leu Thr His Arg Phe Gly His His Ile Ala Pro His 260 265 270 Ile His Ile Phe Ile Ala Asn Ile Tyr Leu Leu Ile Pro Pro Met Met 275 280 285

Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Arg Ile Arg Glu Gly Phe Page 3713

069269_0225_SL.TXT

290 295 300

Phe Lys Phe Leu Ile Ile Lys Cys Val

305 310 <210> 3321 <211> 945 <212> DNA <213> Felis catus <400> 3321

tcaagcaact ttgaccatta atgtcctaat aacatgttcc cgtattttct tggtccttac 60 tccatataca atagggttga gaaaaggggg caccaaaagg tacatatttg caataaatat 120 atggacatgt gcaggcacat ttttcccaaa acggtgagtg aaaatggaaa aaccagctgt 180 ggaatagaag acaagaataa cacagacatg tgacccacat gtgcccagag ccttaaagct 240 agcttctcgg gatggcaggc ggaatacaga gcgcaggatg aaggcatagg atacagcaat 300 gagaattgca tcacatgagc caatgataga agccatactg aggctataac tcttggtggc 360 ccctatgtcc atacatgcca gcttcaccac ggccatgaac tcacaatagg tgtgggcaat 420 aattcgtgat ctgcagtagg gaagttgttt gagcaggatg ggatgtggag aaaagaacgc 480 tacaccccta atcaccacaa taatactcat tatggtgatg cgtgcatggg tgagaatggt 540 agtatggtgc agtggatgac aaatggccac ataacggtca aaggccatgg ccaggaaaaa 600 gccagattcc atagcagtaa aactatgaat gaagaacatt tgggctagac agacatcaaa 660 ggcaatgtca tggactccaa gccagaagag acacagcatc cgaggcagtg tagatgtgga 720 gaggaccagg tcagtgacgg agagcatgca caaaaagaag aacataggct catggagact 780 ccgctctgcc ttcatcacgg ccaggatggt cacattcccc accacagcca ccacgtacat 840 ggagcagaag ggaatcccaa tccagacatg caggtgctct agtcctggga tgcccatcag 900 caagaaggtg acaggagaag gatgagaggt attgaaagga gacat 945

<210> 3322 <211> 314 <212> PRT <213> Felis catus <400> 3322

Page 3714

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Met 1 Ser Pro Phe Asn 5 Thr Ser His Pro Ser Pro Val Thr Phe Leu Leu 10 15 Met Gly Ile Pro Gly Leu Glu His Leu His Val Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ser Met Tyr Val Val Ala Val Val Gly Asn Val Thr Ile Leu 35 40 45 Ala Val Met Lys Ala Glu Arg Ser Leu His Glu Pro Met Phe Phe Phe 50 55 60 Leu Cys Met Leu Ser Val Thr Asp Leu Val Leu Ser Thr Ser Thr Leu 65 70 75 80 Pro Arg Met Leu Cys Leu Phe Trp Leu Gly Val His Asp Ile Ala Phe 85 90 95 Asp Val Cys Leu Ala Gln Met Phe Phe Ile His Ser Phe Thr Ala Met 100 105 110 Glu Ser Gly Phe Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu His His Thr Thr Ile Leu Thr His Ala Arg Ile Thr 130 135 140 Ile Met Ser Ile Ile Val Val Ile Arg Gly Val Ala Phe Phe Ser Pro 145 150 155 160 His Pro Ile Leu Leu Lys Gln Leu Pro Tyr Cys Arg Ser Arg Ile Ile 165 170 175 Ala His Thr Tyr Cys Glu Phe Met Ala Val Val Lys Leu Ala Cys Met 180 185 190 Asp Ile Gly Ala Thr Lys Ser Tyr Ser Leu Ser Met Ala Ser Ile Ile 195 200 205

Page 3715

Gly Ser 210 Cys Asp Ala Ile Leu 215 069269_0225_SL.TXT Ile Ala Val Ser Tyr Ala 220 Phe Ile Leu Arg Ser Val Phe Arg Leu Pro Ser Arg Glu Ala Ser Phe Lys Ala Leu 225 230 235 240 Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Val Phe Tyr Ser Thr 245 250 255 Ala Gly Phe Ser Ile Phe Thr His Arg Phe Gly Lys Asn Val Pro Ala 260 265 270 His Val His Ile Phe Ile Ala Asn Met Tyr Leu Leu Val Pro Pro Phe 275 280 285 Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys Lys Ile Arg Glu His 290 295 300 Val Ile Arg Thr Leu Met Val Lys Val Ala 305 310

<210> 3323 <211> 950 <212> DNA <213> Felis catus <400> 3323 atggcatcca tcaatacatc atatttgacc cccagaactg taatcttgat cagaattcct 60 ggactagaac atgtgcagtt ttggactggg tttcccttct ttgctgtgtg catagtggct 120 cttctgggaa atattatttt actaatcatc attgctacag aacgtagcct gcatcagccc 180 gtgtataact tcctggcagt gctggcggcc actgacatag gactctgcgc agccattgct 240 cccaagatgt tggccatctt ctggttcaga tcttgctcca tggcctttga cagctgcctg 300 acccagctgt tcttcattca tgccttgcag tgcatggagt ctggcattct gttggccatg 360 gcttttgacc actacattgc catctgtgat ccactgagac ccatccaacc tcacgccttc 420 catcctggat cagatgatag caacagtggc gatccgagct acagtgctgg ttggtctgtc 480 acccattctg atcaaaagat ttcatgtttt tcattccatt ctgattgccc cactcttact 540

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gtgagcacat ggccatggtc aagctagctg cagaagacat ccgagtcaat ataacatgtg 600 gtctcctagt aggttttaca atactgggat ttgacatgat ttttgtcctc atttcctata 660 tccttatttt ccaggctgtt tttcatctac accaaaagga ggcacggctc aaagcattta 720 acacatgcac agctcatatt tttgttttcc ttgagtttta tattcttgcc ttcttctcct 780 ttttcagcca ccgttttgga catgttgctc cttctaccca catccttctt tctaccatct 840 atctccttgt gccacctgca ctcaacccta ttgtctatgg tgtaaaacat aaggtaattc 900 gtaagcgtgt ggcacagatt tttcttctga gtcatggatc ccaccagtga 950

<210> 3324 <211> 188 <212> PRT <213> Felis catus

<400> 3324 Thr Ser Tyr Leu Thr Pro Arg Thr Val Ile Leu Met 1 Ala Ser Ile Asn 5 10 15 Ile Arg Ile Pro Gly Leu Glu His Val Gln Phe Trp Thr Gly Phe Pro 20 25 30 Phe Phe Ala Val Cys Ile Val Ala Leu Leu Gly Asn Ile Ile Leu Leu 35 40 45 Ile Ile Ile Ala Thr Glu Arg Ser Leu His Gln Pro Val Tyr Asn Phe 50 55 60 Leu Ala Val Leu Ala Ala Thr Asp Ile Gly Leu Cys Ala Ala Ile Ala 65 70 75 80 Pro Lys Met Leu Ala Ile Phe Trp Phe Arg Ser Cys Ser Met Ala Phe 85 90 95 Asp Ser Cys Leu Thr Gln Leu Phe Phe Ile His Ala Leu Gln Cys Met 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp His Tyr Ile Ala Ile 115 120 125

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Cys Asp 130 Pro Leu Arg Pro Ile Gln Pro His Ala Phe His Pro Gly Ser 135 140 Asp Asp Ser Asn Ser Gly Asp Pro Ser Tyr Ser Ala Gly Trp Ser Val 145 150 155 160 Thr His Ser Asp Gln Lys Ile Ser Cys Phe Ser Phe His Ser Asp Cys 165 170 175 Pro Thr Leu Thr Val Ser Thr Trp Pro Trp Ser Ser 180 185

<210> 3325 <211> 939 <212> DNA <213> Felis catus <400> 3325

atgggatcta ccaacatgtc atatctgaac ccaaagactg tgaccctgat tgggatccct 60 ggactagagc atgtgcagtt ttggatcgga tttcccttcc ttggagtgtg cctggtggct 120 gtgctgggga acatcttctt gttaatcatc atccttacag aacgcagtct tcaccaaccc 180 atgtacatct tcctagcagt tttggcagcc actgacctag gtctctgtgt agccatcgct 240 cccaagatgt tggccatctt ctggtttggc ttgtgctcca tggcttttga tgcttgcctc 300 actcagctct tctttatcca tgccttgcag ggcatggaat ctggtatcct gttggccatg 360 gcctttgacc gctatgttgc catctgtgat cctttgaggc acacatccat cctcacacct 420 ctctttctag ttcaaatcgt actggtggta gtagtccggg caacggtgct tgttggaatt 480 ttacccattc tgcttaaacg cctgcaactt ttccaatctg tggtcattgt ccattcctac 540 tgtgagcaca tggctgtggt caagttggct gcagaagatg tccatattaa taaatcatat 600 gggctctttg tggcctttgc aattctaggt tttgacatga tctttgtctt catctcctac 660 attcttatat ttcaggctgt ttttcgtctt ccccagaagg aggcacgacg caaagcattc 720 aatacttgta ctgcccatat tgttgtcttc ctggagtttt atatccttgc cttttttcct 780 tcttcagcca ccgttttgga catgtatcac cctatgttca tatcctcttg tctaccatct 840 atctgcttgt gccccctgcc cttaacccca ttgtctatgg tgtgaagacc agggagatcc 900

Page 3718

069269_0225_SL.TXT gcatgcgagt tgctcagatt tgtattctga agcctgaca

939 <210> 3326 <211> 294 <212> PRT <213> Felis catus

<400> 3326 Met 1 Gly Ser Thr Asn 5 Met Ser Tyr Leu Asn Pro Lys Thr Val Thr Leu 10 15 Ile Gly Ile Pro Gly Leu Glu His Val Gln Phe Trp Ile Gly Phe Pro 20 25 30 Phe Leu Gly Val Cys Leu Val Ala Val Leu Gly Asn Ile Phe Leu Leu 35 40 45 Ile Ile Ile Leu Thr Glu Arg Ser Leu His Gln Pro Met Tyr Ile Phe 50 55 60 Leu Ala Val Leu Ala Ala Thr Asp Leu Gly Leu Cys Val Ala Ile Ala 65 70 75 80 Pro Lys Met Leu Ala Ile Phe Trp Phe Gly Leu Cys Ser Met Ala Phe 85 90 95 Asp Ala Cys Leu Thr Gln Leu Phe Phe Ile His Ala Leu Gln Gly Met 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Thr Ser Ile Leu Thr Pro Leu Phe Leu Val 130 135 140 Gln Ile Val Leu Val Val Val Val Arg Ala Thr Val Leu Val Gly Ile 145 150 155 160 Leu Pro Ile Leu Leu Lys Arg Leu Gln Leu Phe Gln Ser Val Val Ile 165 170 175

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Val His Ser Tyr Cys Glu His Met Ala 185 Val Val Lys Leu Ala 190 Ala Glu 180 Asp Val His Ile Asn Lys Ser Tyr Gly Leu Phe Val Ala Phe Ala Ile 195 200 205 Leu Gly Phe Asp Met Ile Phe Val Phe Ile Ser Tyr Ile Leu Ile Phe 210 215 220 Gln Ala Val Phe Arg Leu Pro Gln Lys Glu Ala Arg Arg Lys Ala Phe 225 230 235 240 Asn Thr Cys Thr Ala His Ile Val Val Phe Leu Glu Phe Tyr Ile Leu 245 250 255 Ala Phe Phe Pro Ser Ser Ala Thr Val Leu Asp Met Tyr His Pro Met 260 265 270 Phe Ile Ser Ser Cys Leu Pro Ser Ile Cys Leu Cys Pro Leu Pro Leu 275 280 285 Thr Pro Leu Ser Met Val

290 <210> 3327 <211> 945 <212> DNA <213> Felis catus <400> 3327

tcagtttcta tgacagcgga ggatccgtag tacccgctcc cgcatttgct tagtccgggc 60 tccataaatc aaggggttgg ccatgggagg cactaggaag tagaggttgt caatgataat 120 ctggatatag ggagccatat ggtagcctaa aatctgggcc aggacagaga agacaacagg 180 agaataaaag agagctatga cacaaagatg ggagccacat gtactgagag ctttgccccc 240 tgcctcccaa gaggggatcc gaaagacagc atgaaggatc agcccatagg acagaatgat 300 aaaaagcaaa tcaaatccca cagatgttac aataaccatg aggccataga caatgtggtt 360

Page 3720

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ggagatgtcc ccacaggcta tctgtaccac agccatgtag gcacagtagg agtaagagat 420 gatgtgggtt tggaagcttt ccagtctttt tgccaggatg ggtgctggag tcagcactgc 480 caccgccctt gtcaggacag ccagagccat cttcacaagt atgttgttag caaggatggt 540 tgtatatctc agagggtacc agatagccac aaatctgtca aaagccatgg ctaggaggat 600 cccagactcc atgacataaa atgaagggat gaaaaacatc tgtgcgaggc aggcattaaa 660 gctgatgtct ttggcattca tccagaagat ccctagcatg cggggcacag tgacactgac 720 cagggacagg tcaacaacag acagcatggc caggaggaga aacatgggct catgaagact 780 cttctccacc cagatgatgc ataagatggc ggcattccca atcattgtaa tgacaaatac 840 caagaaaaaa ggcacagaga accagccatg ggaagattcc aagccaggaa ttccagccag 900 gacaaatgtc aagggttgag gaatggagtt <210> 3328 <211> 314 <212> PRT <213> Felis catus <400> 3328 gttgcaagag gacat 945 Met Ser Ser Cys Asn Asn Ser Ile 1 5 Pro Gln Pro 10 Leu Thr Phe Val Leu 15 Ala Gly Ile Pro Gly Leu Glu Ser 20 Ser His Gly 25 Trp Phe Ser Val Pro 30 Phe Phe Leu Val Phe Val Ile Thr 35 40 Met Ile Gly Asn Ala Ala Ile Leu 45 Cys Ile Ile Trp Val Glu Lys Ser 50 55 Leu His Glu Pro Met Phe Leu Leu 60 Leu Ala Met Leu Ser Val Val Asp 65 70 Leu Ser Leu 75 Val Ser Val Thr Val 80 Pro Arg Met Leu Gly Ile Phe Trp 85 Met Asn Ala 90 Lys Asp Ile Ser Phe 95 Asn Ala Cys Leu Ala Gln Met Phe Phe Ile Pro Ser Phe Tyr Val Met

Page 3721

100

069269_0225_SL.TXT 105 110

Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Trp Tyr Pro Leu Arg Tyr Thr Thr Ile Leu Ala Asn Asn Ile Leu Val 130 135 140 Lys Met Ala Leu Ala Val Leu Thr Arg Ala Val Ala Val Leu Thr Pro 145 150 155 160 Ala Pro Ile Leu Ala Lys Arg Leu Glu Ser Phe Gln Thr His Ile Ile 165 170 175 Ser Tyr Ser Tyr Cys Ala Tyr Met Ala Val Val Gln Ile Ala Cys Gly 180 185 190 Asp Ile Ser Asn His Ile Val Tyr Gly Leu Met Val Ile Val Thr Ser 195 200 205 Val Gly Phe Asp Leu Leu Phe Ile Ile Leu Ser Tyr Gly Leu Ile Leu 210 215 220 His Ala Val Phe Arg Ile Pro Ser Trp Glu Ala Gly Gly Lys Ala Leu 225 230 235 240 Ser Thr Cys Gly Ser His Leu Cys Val Ile Ala Leu Phe Tyr Ser Pro 245 250 255 Val Val Phe Ser Val Leu Ala Gln Ile Leu Gly Tyr His Met Ala Pro 260 265 270 Tyr Ile Gln Ile Ile Ile Asp Asn Leu Tyr Phe Leu Val Pro Pro Met 275 280 285 Ala Asn Pro Leu Ile Tyr Gly Ala Arg Thr Lys Gln Met Arg Glu Arg 290 295 300

Val Leu Arg Ile Leu Arg Cys His Arg Asn

Page 3722

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305

310 <210> 3329 <211> 945 <212> DNA <213> Felis catus <400> 3329 tcaagtgact tttaccttta gagaactaag gacatggtct cgaatttttt tggttctaat 60 accataaaca atggggttaa ggaaaggtgg taccagaagg tacatattgg caataaagat 120 atgaatttgg ggggccacat tgtggccaaa gcggtgagtg aggaaggtaa agacagctgt 180 ggagtagaaa acaaggatga cacagacatg agagccacag gttcctagag ctttaaaact 240 tgcttcctgt gatggaaggc gaaagactgc acggaggatt agggcataag agacagcaat 300 gaaaaagcca tcgcaggaac caatgacaga ggctacactg aggctgtaac gtttggtagc 360 tcctgtgtcc acacatgcca gcttcaccac ggccatgaac tcacagtagg tgtgggtaat 420 gactcgtgtt ctgcagtagg gcagctgcct gagcaggata ggatgtgggg aaaagaaggc 480 cactccccgg agtaccacag aaactcccat tttggcaatg cgagcatggg tgagaatcgt 540 ggtatggtgc agcggatgac aaatggccac gtaacggtca aaggccatgg ccaggaaaaa 600 acctgattcc atagcagtaa aactatggat gaagaacatt tgagccaggc aagcatcaaa 660 ggcaatgtca cgcgctccaa gccagaagag acagagcatg cgaggcagtg tagatgtgga 720 gaggaccagg tcagtgacgg agagcatgca cagaaagagg aacataggct catggagact 780 ccgctctgcc ctcaccacgg ccaggatggt cacattcccc accacagcca ccatgtacat 840 ggagcagaag ggaatcccaa tccagatatg caggtgctct agtcctggga tgcccatcag 900 caagaaggtg tctggagatg tttgagattt attggctggt cccat 945 <210> 3330 <211> 314 <212> PRT <213> Felis catus <400> 3330

Met Gly Pro Ala Asn Lys Ser Gln Thr Ser Pro Asp Thr Phe Leu Leu 1 5 10 15

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Met Gly Ile Pro Gly 20 Leu Glu His Leu His Ile Trp Ile Gly Ile Pro 25 30 Phe Cys Ser Met Tyr Met Val Ala Val Val Gly Asn Val Thr Ile Leu 35 40 45 Ala Val Val Arg Ala Glu Arg Ser Leu His Glu Pro Met Phe Leu Phe 50 55 60 Leu Cys Met Leu Ser Val Thr Asp Leu Val Leu Ser Thr Ser Thr Leu 65 70 75 80 Pro Arg Met Leu Cys Leu Phe Trp Leu Gly Ala Arg Asp Ile Ala Phe 85 90 95 Asp Ala Cys Leu Ala Gln Met Phe Phe Ile His Ser Phe Thr Ala Met 100 105 110 Glu Ser Gly Phe Phe Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu His His Thr Thr Ile Leu Thr His Ala Arg Ile Ala 130 135 140 Lys Met Gly Val Ser Val Val Leu Arg Gly Val Ala Phe Phe Ser Pro 145 150 155 160 His Pro Ile Leu Leu Arg Gln Leu Pro Tyr Cys Arg Thr Arg Val Ile 165 170 175 Thr His Thr Tyr Cys Glu Phe Met Ala Val Val Lys Leu Ala Cys Val 180 185 190 Asp Thr Gly Ala Thr Lys Arg Tyr Ser Leu Ser Val Ala Ser Val Ile 195 200 205 Gly Ser Cys Asp Gly Phe Phe Ile Ala Val Ser Tyr Ala Leu Ile Leu 210 215 220

Page 3724

Arg 225 Ala Val Phe Arg Leu 230 Pro 069269_0225_SL.TXT Ser Gln Glu Ala Ser Phe 235 Lys Ala Leu 240 Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Val Phe Tyr Ser Thr 245 250 255 Ala Val Phe Thr Phe Leu Thr His Arg Phe Gly His Asn Val Ala Pro 260 265 270 Gln Ile His Ile Phe Ile Ala Asn Met Tyr Leu Leu Val Pro Pro Phe 275 280 285 Leu Asn Pro Ile Val Tyr Gly Ile Arg Thr Lys Lys Ile Arg Asp His 290 295 300 Val Leu Ser Ser Leu Lys Val Lys Val Thr 305 310

<210> 3331 <211> 945 <212> DNA <213> Felis catus <400> 3331

tcagacaact ttgaccttta gtgctctaag aacatgctcc tgtattttct tggtccttac 60 tccatacaca atggggttga gaaaaggggg caccaaaagg tacatatttg caataaatat 120 atggacatgt gcaggcacat ttttcccaaa acggtgagtg aaaatggaaa aaccagctgt 180 ggaatagaag acaagaataa cacagacatg tgatccacat gtgcccagag ccttaaagct 240 agcttctcgg gatggcaggc ggaatacaga gcgcaggatg aaggcatagg atacagcagt 300 gagaatggca tcacatgagc caatgataga agccacactg aggctataac gtgtggtggc 360 tcctgtgtcc acacatgcca gcttcaccac agccatgaac tcacagtagg tgtgggcaat 420 ggttcgtgtt ctgcagtagg gcagctgcct gagcaggatg ggatgtggag aaaagaaggc 480 tacgccccga atcaccacaa taatacccat catggtgatg cgcgcatggg tgagaatggt 540 agtgtggtgc agtggatgac aaatggccac gtaacggtca atggccatgg ccaggaaaaa 600 acccgattcc atggtggtaa agctatggat gaagaacatt tgggtcaggc aagcatcaaa 660

Page 3725

069269_0225_SL.TXT tgtaatgtca tgggctccaa gccagaaaag acaaagcatg cggggcagtg tagatgtgga gaggaccagg tcagtgacgg agagcatgca caaaaagaag aacataggct catggagact ccgctctgcc ttcaccacgg ccaggatggt cacattcccc accacagcca ccacatacat ggagcagaag ggaatcccaa tccagacatg caggtgctct agtcctggga tgcccatcag caagaaggtg ataggagagg gacgagaggt gttgagagga ggcat

720

780

840

900

945 <210> 3332 <211> 314 <212> PRT <213> Felis catus <400> 3332

Met Pro Pro 1 Leu Asn Thr Ser Arg 5 Pro Ser Pro Ile Thr Phe Leu Leu 10 15 Met Gly Ile Pro Gly Leu Glu His Leu His Val Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ser Met Tyr Val Val Ala Val Val Gly Asn Val Thr Ile Leu 35 40 45 Ala Val Val Lys Ala Glu Arg Ser Leu His Glu Pro Met Phe Phe Phe 50 55 60 Leu Cys Met Leu Ser Val Thr Asp Leu Val Leu Ser Thr Ser Thr Leu 65 70 75 80 Pro Arg Met Leu Cys Leu Phe Trp Leu Gly Ala His Asp Ile Thr Phe 85 90 95 Asp Ala Cys Leu Thr Gln Met Phe Phe Ile His Ser Phe Thr Thr Met 100 105 110 Glu Ser Gly Phe Phe Leu Ala Met Ala Ile Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu His His Thr Thr Ile Leu Thr His Ala Arg Ile Thr 130 135 140

Page 3726

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Met Met Gly 145 Ile Ile Val Val Ile Arg Gly Val Ala Phe Phe Ser Pro 150 155 160 His Pro Ile Leu Leu Arg Gln Leu Pro Tyr Cys Arg Thr Arg Thr Ile 165 170 175 Ala His Thr Tyr Cys Glu Phe Met Ala Val Val Lys Leu Ala Cys Val 180 185 190 Asp Thr Gly Ala Thr Thr Arg Tyr Ser Leu Ser Val Ala Ser Ile Ile 195 200 205 Gly Ser Cys Asp Ala Ile Leu Thr Ala Val Ser Tyr Ala Phe Ile Leu 210 215 220 Arg Ser Val Phe Arg Leu Pro Ser Arg Glu Ala Ser Phe Lys Ala Leu 225 230 235 240 Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Val Phe Tyr Ser Thr 245 250 255 Ala Gly Phe Ser Ile Phe Thr His Arg Phe Gly Lys Asn Val Pro Ala 260 265 270 His Val His Ile Phe Ile Ala Asn Met Tyr Leu Leu Val Pro Pro Phe 275 280 285 Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys Lys Ile Gln Glu His 290 295 300 Val Leu Arg Ala Leu Lys Val Lys Val Val 305 310 <210> 3333 <211> 951 <212> DNA <213> Felis catus <400> 3333 atggcgtccg ttaatatgtc atatctagac cccacaacac tgatgctaat tgggatcccc 60

Page 3727

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ggactacagg acgtgcaatt ttggattggg ttttccttct ttgcaatatg cctggtggct 120 cttctgggaa atactatttt actaatcatc attcctacag aacacagcct gcatcaaccc 180 atgtacgttt tcctggcagt gctggcagcc actgacatag ggctctgtgt agccattgct 240 cccaagatgt tggccatctt ctcgtttggc tcatgctcca tggcttttga tgcttgctta 300 gcccagcttt ttttcattca tgccttgcag ggcatggaat ctggcatcct gctggccatg 360 gcctttgacc gctatgttgc catctgtgat ccactgaggc acgcgtccat cctcacacca 420 tccatcctgg tcactatggt gctggttgtg gcaattcggg caatggtgct tgttggcatt 480 ttaccaattt taatcaaaag actacacctt ttccattcca ctgtaattgc tcactcctac 540 tgtgagcaca tggctgtggt caagctagct gcagaagaca tccgagtcaa taaaacatgt 600 ggtctcctcg taggttttac aatactggga tttgacatga ttttcatctt catttcctat 660 atccttattt tccaggctgt ttttcatcta caccaaaagg aggcacggct caaagcattt 720 aacacatgca cagctcatat ttttgttttc cttgagtttt atattcttgc tttcttctcc 780 tttttcagcc accgttttgg acatgttgct ccttctaccc acatccttct ttctaccatc 840 tatctccttg tgccacctgc actcaaccct attgtctatg gtgtaaaaaa taaggtaatt 900 cgtaagcgtg tggcacagat ttttcttctg aatcgtcact cccagcagta a 951

<210> 3334 <211> 316 <212> PRT <213> Felis catus

<400> 3334 Val Asn Met Ser Tyr Leu Asp Pro Thr Thr Leu Met Leu Met 1 Ala Ser 5 10 15 Ile Gly Ile Pro Gly Leu Gln Asp Val Gln Phe Trp Ile Gly Phe Ser 20 25 30 Phe Phe Ala Ile Cys Leu Val Ala Leu Leu Gly Asn Thr Ile Leu Leu 35 40 45 Ile Ile Ile Pro Thr Glu His Ser Leu His Gln Pro Met Tyr Val Phe 50 55 60

Page 3728

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Leu 65 Ala Val Leu Ala Ala Thr Asp Ile Gly Leu Cys Val Ala Ile Ala 70 75 80 Pro Lys Met Leu Ala Ile Phe Ser Phe Gly Ser Cys Ser Met Ala Phe 85 90 95 Asp Ala Cys Leu Ala Gln Leu Phe Phe Ile His Ala Leu Gln Gly Met 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Ala Ser Ile Leu Thr Pro Ser Ile Leu Val 130 135 140 Thr Met Val Leu Val Val Ala Ile Arg Ala Met Val Leu Val Gly Ile 145 150 155 160 Leu Pro Ile Leu Ile Lys Arg Leu His Leu Phe His Ser Thr Val Ile 165 170 175 Ala His Ser Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Ala Glu 180 185 190 Asp Ile Arg Val Asn Lys Thr Cys Gly Leu Leu Val Gly Phe Thr Ile 195 200 205 Leu Gly Phe Asp Met Ile Phe Ile Phe Ile Ser Tyr Ile Leu Ile Phe 210 215 220 Gln Ala Val Phe His Leu His Gln Lys Glu Ala Arg Leu Lys Ala Phe 225 230 235 240 Asn Thr Cys Thr Ala His Ile Phe Val Phe Leu Glu Phe Tyr Ile Leu 245 250 255 Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly His Val Ala Pro Ser 260 265 270

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Thr His Ile Leu Leu Ser Thr Ile Tyr Leu Leu Val Pro Pro Ala Leu 275 280 285 Asn Pro Ile Val Tyr Gly Val Lys Asn Lys Val Ile Arg Lys Arg Val 290 295 300 Ala Gln Ile Phe Leu Leu Asn Arg His Ser Gln Gln 305 310 315

<210> 3335 <211> 888 <212> DNA <213> Felis catus <400> 3335

ttggaggaat cgatctctga tcgtcttggt tcttatagat cattcaccat ggatggagca 60 aggaggtaga tgctagccac aaagatgtga atatgaggag ccatatggcc accaaatctg 120 tgagtgagga aggagaaaaa ggctggagca tagaccacta agatcacaca cacatgggat 180 ccacgtgttt ccaaggtctt gagcttagca cctttggatg gaagatggaa gacagtgtaa 240 aggatgataa cataggaaca taggattaat atgaaatcta aacctccagc aaggaaggca 300 gcagccagcc tgcagattct gcagatcctt gtctcttcac aaggtagcct gatcagagcc 360 ataaattcac agtaagtgtg agagatgaca gtagttctgc agtaaggaag ccactgaggc 420 atgaaaggtt gaggactgaa gagcaaaacc ccatggagga caatagctag ccccaagttc 480 ttgatgactc tatgtgtcag gatagcaaaa tgtctcagag gatcacagat tgccatatac 540 tggtcaaagg ccatggccaa gataaaccct gaggccatgt tgcatagtga atgaatgaga 600 aacacttgtg tgagtgttct tcaaaataga tctccctacc atggaaccaa aaaatgctga 660 ggatttgggc acagtgatgg agatgaacaa gtcagccaca gagagcgtac agaggaagaa 720 gtacatgggg tcatgcaggt tggaatctgt tctgacaata aagagaagaa ttacccagca 780 gagcactcag gtagataggc agaagggcca tgagagccaa gtgtggattt cctccatccc 840 tagaaggcca aggagaagaa aagtactggg gtggaaattg gtattatt 888

<210> 3336

Page 3730

069269_0225_SL.TXT <211> 83 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (83)..(83)

<223> Any amino acid <400> 3336 Met Glu Pro Lys Asn Ala Glu Asp Leu Gly Thr Val Met Glu Met Asn 1 5 10 15 Lys Ser Ala Thr Glu Ser Val Gln Arg Lys Lys Tyr Met Gly Ser Cys 20 25 30 Arg Leu Glu Ser Val Leu Thr Ile Lys Arg Arg Ile Thr Gln Gln Ser 35 40 45 Thr Gln Val Asp Arg Gln Lys Gly His Glu Ser Gln Val Trp Ile Ser 50 55 60 Ser Ile Pro Arg Arg Pro Arg Arg Arg Lys Val Leu Gly Trp Lys Leu 65 70 75 80 Val Leu Xaa

<210> 3337 <211> 947 <212> DNA <213> Felis catus <400> 3337 atggtcttct tcaatggtag tagctacaga ccttttcttc tgagtggttt tcctggtctg gaagactcac atccaatgat ttccattttg ttttgtgtcc tctacctgat tgccctaatg ggtaacatca ccatcttagt ggttattaaa gtggaacggt cacttcatac acccatgtac ttttttctct ccatgctggc tgctagtgac cttggaatct gtgctaccac cctgcccacc ctgctcaagc ttttctggtc taatgttcgg gaaatagact ttgatgcctg cctcatccag atgttcttta tccatgtgtt ttccttaatg gagtcaggca tcctcctcac catggctttt

120

180

240

300

360

Page 3731

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gaccgctatg tggccatctc caacccactc aggtacacta ctgttttgac tgattctacc 420 attgccaaaa taggtgtggg gcttctgcta cgggctgttg ctgtcatctt cccaggaccc 480 tttctcatca aacgactgag gttttgtaag gctaatgtgc tctcccactc atactgcctg 540 cacccagata taatcaagct ctcttgttct gaccaccgaa taaatagcat ctatggcctc 600 atcatcattc tcatcacctt tggtgtggac tctgtactca ttctcctctc ttatttgaag 660 atcctgatta ctgtgctagg catcgcctcc cgggaacaac aatttaaggc ccttaacact 720 tgtgtctccc acatctgtgc tgtgcttctg gtttatgtcc ctatgctggg tgtatctatt 780 atccatcgct ttgggaaaca tgttccatct atggtgcaca ttatcatggg ttatatatac 840 ctattgattc ctcctgttct caaccctgtt gtatactgtg ttaaaacccg agagatacgt 900 acccgtattc taggtaatct actgaaatta tagctgaagt actttag 947 <210> 3338 <211> 310 <212> PRT <213> Felis catus <400> 3338 Met Val Phe Phe Asn Gly Ser Ser Tyr Arg Pro Phe Leu Leu Ser Gly 1 5 10 15 Phe Pro Gly Leu Glu Asp Ser His Pro Met Ile Ser Ile Leu Phe Cys 20 25 30 Val Leu Tyr Leu Ile Ala Leu Met Gly Asn Ile Thr Ile Leu Val Val 35 40 45 Ile Lys Val Glu Arg Ser Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Met Leu Ala Ala Ser Asp Leu Gly Ile Cys Ala Thr Thr Leu Pro Thr 65 70 75 80 Leu Leu Lys Leu Phe Trp Ser Asn Val Arg Glu Ile Asp Phe Asp Ala 85 90 95

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Cys Leu Ile Gln Met Phe Phe Ile His Val Phe Ser Leu Met Glu Ser 100 105 110 Gly Ile Leu Leu Thr Met Ala Phe Asp Arg Tyr Val Ala Ile Ser Asn 115 120 125 Pro Leu Arg Tyr Thr Thr Val Leu Thr Asp Ser Thr Ile Ala Lys Ile 130 135 140 Gly Val Gly Leu Leu Leu Arg Ala Val Ala Val Ile Phe Pro Gly Pro 145 150 155 160 Phe Leu Ile Lys Arg Leu Arg Phe Cys Lys Ala Asn Val Leu Ser His 165 170 175 Ser Tyr Cys Leu His Pro Asp Ile Ile Lys Leu Ser Cys Ser Asp His 180 185 190 Arg Ile Asn Ser Ile Tyr Gly Leu Ile Ile Ile Leu Ile Thr Phe Gly 195 200 205 Val Asp Ser Val Leu Ile Leu Leu Ser Tyr Leu Lys Ile Leu Ile Thr 210 215 220 Val Leu Gly Ile Ala Ser Arg Glu Gln Gln Phe Lys Ala Leu Asn Thr 225 230 235 240 Cys Val Ser His Ile Cys Ala Val Leu Leu Val Tyr Val Pro Met Leu 245 250 255 Gly Val Ser Ile Ile His Arg Phe Gly Lys His Val Pro Ser Met Val 260 265 270 His Ile Ile Met Gly Tyr Ile Tyr Leu Leu Ile Pro Pro Val Leu Asn 275 280 285 Pro Val Val Tyr Cys Val Lys Thr Arg Glu Ile Arg Thr Arg Ile Leu 290 295 300

Page 3733

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Gly Asn Leu Leu Lys Leu 305 310 <210> 3339 <211> 955 <212> DNA <213> Felis catus <400> 3339 ctacatcata gtagaactga tttttgtgcg gagaagtagg tagaggactc cttgacggat 60 ctgtttggtc ttcacactat agatgattgg attgagcaca ggtggaacca ataagtagat 120 gtgagccatg aagatacgga tcagtgggga ggagtgtttg gcaaaacggt ggacaataga 180 taacccaatc ataggcacat atagaatgag tacagcacag atgtgggacg cacacgtgtt 240 gagagcctta agccgccctt cacgtgacgc aatttttaat acagagttaa ggatgtacac 300 ataagacaca aaaataccca gagagtccat tccccacagc acactgatta gaaccaaccc 360 atatataaca ttaaacttgg tgtcagcaca ggcaaggcgg atcatgtcct ggtgcagaca 420 atatgaatga gaaaggatgt gagagtggca gaaaggaaag aaggccagcc gagccagaag 480 tggaatcatg gcacaggcac tcctaagcag ggctgcaatt ccaattttca tgataagtct 540 tggggtgaga atggtagcat atcgtagagg gtggcagata gccacgtagc ggtcaaaggc 600 catggccaag agcacagatg attccgtgaa ggagaaagtg tgaatgaaaa acatttggac 660 cacacaggta ctgaactgga tttccctgga aatggaccac aacaccctga acagtgatat 720 catggtgggc atggacatgc ccatgtcggt gagggaaagc atggccagaa agtagtacat 780 gggctgatgg agcctggggt ctgtccgaac aatatgcagg atggtgcagt tacccatgat 840 tccaacaagg tacaggagac agaatggaat ggatatccag tggtggaatt cctcatagcc 900 agggatacct gagagataga atgtggagga cagggtatta ctggagttta aggtt 955 <210> 3340 <211> 317 <212> PRT <213> Felis catus <400> 3340

Thr Leu Asn Ser Ser Asn Thr Leu Ser Ser Thr Phe Tyr Leu Ser Gly 1 5 10 15

Page 3734

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Ile Pro Gly Tyr 20 Glu Glu Phe His His Trp Ile Ser Ile Pro Phe Cys 25 30 Leu Leu Tyr Leu Val Gly Ile Met Gly Asn Cys Thr Ile Leu His Ile 35 40 45 Val Arg Thr Asp Pro Arg Leu His Gln Pro Met Tyr Tyr Phe Leu Ala 50 55 60 Met Leu Ser Leu Thr Asp Met Gly Met Ser Met Pro Thr Met Ile Ser 65 70 75 80 Leu Phe Arg Val Leu Trp Ser Ile Ser Arg Glu Ile Gln Phe Ser Thr 85 90 95 Cys Val Val Gln Met Phe Phe Ile His Thr Phe Ser Phe Thr Glu Ser 100 105 110 Ser Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Ala Thr Ile Leu Thr Pro Arg Leu Ile Met Lys Ile 130 135 140 Gly Ile Ala Ala Leu Leu Arg Ser Ala Cys Ala Met Ile Pro Leu Leu 145 150 155 160 Ala Arg Leu Ala Phe Phe Pro Phe Cys His Ser His Ile Leu Ser His 165 170 175 Ser Tyr Cys Leu His Gln Asp Met Ile Arg Leu Ala Cys Ala Asp Thr 180 185 190 Lys Phe Asn Val Ile Tyr Gly Leu Val Leu Ile Ser Val Leu Trp Gly 195 200 205 Met Asp Ser Leu Gly Ile Phe Val Ser Tyr Val Tyr Ile Leu Asn Ser 210 215 220

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Val 225 Leu Lys Ile Ala Ser Arg Glu Gly Arg Leu Lys Ala Leu Asn Thr 230 235 240 Cys Ala Ser His Ile Cys Ala Val Leu Ile Leu Tyr Val Pro Met Ile 245 250 255 Gly Leu Ser Ile Val His Arg Phe Ala Lys His Ser Ser Pro Leu Ile 260 265 270 Arg Ile Phe Met Ala His Ile Tyr Leu Leu Val Pro Pro Val Leu Asn 275 280 285 Pro Ile Ile Tyr Ser Val Lys Thr Lys Gln Ile Arg Gln Gly Val Leu 290 295 300 Tyr Leu Leu Leu Arg Thr Lys Ile Ser Ser Thr Met Met 305 310 315

<210> 3341 <211> 990 <212> DNA <213> Felis catus <400> 3341

tggctacttg ggacagactc atgacaggct ctacctccag tatggaacag tttgtttcat 60 tccacctcac tgggattcct ggctccaaga atgttaatca ttttatttcc atcccctttc 120 atgtgtgcta cttgattgga atagtgggca actgtacaat ccttcacatt atccacatag 180 acaagagtct ccacaagccc atgtactact tcctggccat tctgtccctt actgacatgg 240 gcctgtctat ctctaccctg cccacagtat taaaaaatct tctggtttga tactaggaag 300 attgaggtga atgcttgtgt atcccagatg tattttattc atactttttc cctgatggag 360 tcagctgtgc ttctagccat ggtttttgac cgctatgttg ccatttgtga tcctttgagg 420 tattccagca aactcactcc acagcacact gtctacatag gggtcttcat tataatcaga 480 tgttctgttg tcctccctgt tattcttgtt tgtattccca cactttcctt ctgtcactcc 540 catgttctct ctcactcttt ctgcttgcat caagatgtca tccagttgga ctgtgatgac 600 atctcattca acattttata tggcttgttt gttgttggat tttattgggg tgtagattct 660

Page 3736

069269_0225_SL.TXT ttaggaatct tgttatctta tgcattcatc ctccattctg tgctaggcat tgcatcctag 720 ggagggaagc tcaaagctct caatacatgt gcttcccaca tttgtgctgt attcattcta 780 tatgtgccca tgatcgggct atccttagtg catcgctttg caaaacactc ctcccccttt 840 ttccacatga acatgtccaa tatttacctc ttagttccaa cagtacttaa ctcaatcatt 900 tatagcatca agacaaagca gattccctaa ggtttcctaa gggtactatc acccaaaagg 960 gttgggcttg ctcacactta aatgggataa 990 <210> 3342 <211> 95 <212> PRT <213> Felis catus

<400> 3342 Arg Leu 5 Met Thr Gly Ser Thr Ser Ser Met Glu Gln Ala Thr 1 Trp Asp 10 15 Phe Val Ser Phe His Leu Thr Gly Ile Pro Gly Ser Lys Asn Val Asn 20 25 30 His Phe Ile Ser Ile Pro Phe His Val Cys Tyr Leu Ile Gly Ile Val 35 40 45 Gly Asn Cys Thr Ile Leu His Ile Ile His Ile Asp Lys Ser Leu His 50 55 60 Lys Pro Met Tyr Tyr Phe Leu Ala Ile Leu Ser Leu Thr Asp Met Gly 65 70 75 80 Leu Ser Ile Ser Thr Leu Pro Thr Val Leu Lys Asn Leu Leu Val 85 90 95

<210> 3343 <211> 955 <212> DNA <213> Felis catus <400> 3343 atggcaacct ttaactccag taataccctg tcctccacat tctatctctc aggtatccct 60

Page 3737

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ggctatgagg aattccacca ctggatatcc attccattct gtctcctgta ccttgttgga 120 atcatgggta actgcaccat cctgcatatt gttcggacag accccaggct ccatcagccc 180 atgtactact ttctggccat gctttccctc accgacatgg gcatgtccat gcccaccatg 240 atatcactgt tcagggtgtt gtggtccatt tccagggaaa tccagttcag tacctgtgtg 300 gtccaaatgt ttttcattca cactttctcc ttcacggaat catctgtgct cttggccatg 360 gcctttgacc gctacgtggc tatctgccac cctctacgat atgctaccat tctcaccccc 420 aagacttatc atgaaaattg gaattgcagc cctgcttagg agtgcctgtg ccatgattcc 480 acttctggct cggctggcct tctttccttt ctgccactct cacatccttt ctcattcata 540 ttgtctgcac caggacatga tccgccttgc ctgtgctgac accctgttta atgttatata 600 tgggttgctt cttgtcgttg tgctgtgggg aatggactct ctgggtattt ttgtgtctta 660 tgtgtacatc cttaactctg tattaaaaat tgcgtcacgt gaagggcggc ttaaggctct 720 caacacgtgt gcgtcccaca tctgtgttgt actcatttta tatgtgccta tgatggggct 780 atctattgtc catcgttttg ccaaacactc ctccccactg atccatatct tcatggctca 840 catctactta ttggttccac ctgtgctcaa tccaatcatc tatagtgtga agaccaaaca 900 gatccgccaa ggagtcctct acctacttct ccgcacaaaa accggttcta ctatg 955

<210> 3344 <211> 185 <212> PRT <213> Felis catus <400> 3344

Met 1 Leu Pro Phe Ser Pro 5 Pro Arg Leu Ile 10 Met Lys Ile Gly Ile 15 Ala Ala Leu Leu Arg Ser Ala Cys Ala Met Ile Pro Leu Leu Ala Arg Leu 20 25 30 Ala Phe Phe Pro Phe Cys His Ser His Ile Leu Ser His Ser Tyr Cys 35 40 45 Leu His Gln Asp Met Ile Arg Leu Ala Cys Ala Asp Thr Leu Phe Asn 50 55 60

Page 3738

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Val Ile Tyr Gly Leu Leu Leu Val Val Val Leu Trp Gly Met Asp Ser 80 65 70 75 Leu Gly Ile Phe Val Ser Tyr Val Tyr Ile Leu Asn Ser Val Leu Lys 85 90 95 Ile Ala Ser Arg Glu Gly Arg Leu Lys Ala Leu Asn Thr Cys Ala Ser 100 105 110 His Ile Cys Val Val Leu Ile Leu Tyr Val Pro Met Met Gly Leu Ser 115 120 125 Ile Val His Arg Phe Ala Lys His Ser Ser Pro Leu Ile His Ile Phe 130 135 140 Met Ala His Ile Tyr Leu Leu Val Pro Pro Val Leu Asn Pro Ile Ile 145 150 155 160 Tyr Ser Val Lys Thr Lys Gln Ile Arg Gln Gly Val Leu Tyr Leu Leu 165 170 175 Leu Arg Thr Lys Thr Gly Ser Thr Met 180 185

<210> 3345 <211> 972 <212> DNA <213> Felis catus <400> 3345

tcattttggt ttgttacaga gccctagtac atgcatcctt atctcctttg tctttactcc 60 ataaacaatg gggttcatag tgggtggcac cagtaagtag aggtttgcca ggaggataag 120 gacatgcttg ggtacatgat ctccaaagcg atgggtaaag aaggaaaaga aggccagagt 180 ataaaatatc aagatgacac atatatgagc tccacatgtt gcaaatgctt ttgtccgggc 240 ttccctagaa ggtagttgga agactgttct caggattagc cagtaggaca gggagatgag 300 gaaaaagtct agccctgtgg tgaggagagc agcagtgagc ccataaatgc tattgagggc 360 aatgctattg caggccaact tggcaatgcc catgttctca cagtaggtat ggtggatgat 420

Page 3739

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gttttcccgg caaaaacgta gccggagaat gaggaggaca ccaggagtga ccacagccac 480 actccgagtc accagagcca gacccacctt gctaatgaga gaacctgtaa gaaaggttgc 540 ataatggagt ggtgtacaga tagccacgta gcgatcaaaa gccatggcca agagaacagc 600 agattcagag aggaacagag catgaacaaa aaacatctgt gtgagacatg cagggaatgt 660 taatggggaa ggacccttcc agaagataag aagcatttgg ggcactgtca cagtacaaag 720 gagaacatca ttgagtgcca gcatggccag gaagagatac atgggttcat ggaggttcct 780 gtccccaacc accactgcca taaccaggcc attgcctatc acagccaaaa ggtacatgaa 840 gctgaagggg atggagatcc agatttggaa gtcttctaat cctgggactc cagtcagcag 900 aaaggcagtg aggtgagtgg atgtagaatt ggatattctt gtagacaggt ggcccaagtc 960 tgttacatga aa 972

<210> 3346 <211> 323 <212> PRT <213> Felis catus <400> 3346

Phe 1 His Val Thr Asp Leu Gly His 5 Leu Ser Thr Arg Ile Ser Asn Ser 10 15 Thr Ser Thr His Leu Thr Ala Phe Leu Leu Thr Gly Val Pro Gly Leu 20 25 30 Glu Asp Phe Gln Ile Trp Ile Ser Ile Pro Phe Ser Phe Met Tyr Leu 35 40 45 Leu Ala Val Ile Gly Asn Gly Leu Val Met Ala Val Val Val Gly Asp 50 55 60 Arg Asn Leu His Glu Pro Met Tyr Leu Phe Leu Ala Met Leu Ala Leu 65 70 75 80 Asn Asp Val Leu Leu Cys Thr Val Thr Val Pro Gln Met Leu Leu Ile 85 90 95

Page 3740

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Phe Trp Lys Gly Pro Ser 100 Pro Leu Thr Phe Pro 105 Ala Cys Leu 110 Thr Gln Met Phe Phe Val His Ala Leu Phe Leu Ser Glu Ser Ala Val Leu Leu 115 120 125 Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Thr Pro Leu His Tyr 130 135 140 Ala Thr Phe Leu Thr Gly Ser Leu Ile Ser Lys Val Gly Leu Ala Leu 145 150 155 160 Val Thr Arg Ser Val Ala Val Val Thr Pro Gly Val Leu Leu Ile Leu 165 170 175 Arg Leu Arg Phe Cys Arg Glu Asn Ile Ile His His Thr Tyr Cys Glu 180 185 190 Asn Met Gly Ile Ala Lys Leu Ala Cys Asn Ser Ile Ala Leu Asn Ser 195 200 205 Ile Tyr Gly Leu Thr Ala Ala Leu Leu Thr Thr Gly Leu Asp Phe Phe 210 215 220 Leu Ile Ser Leu Ser Tyr Trp Leu Ile Leu Arg Thr Val Phe Gln Leu 225 230 235 240 Pro Ser Arg Glu Ala Arg Thr Lys Ala Phe Ala Thr Cys Gly Ala His 245 250 255 Ile Cys Val Ile Leu Ile Phe Tyr Thr Leu Ala Phe Phe Ser Phe Phe 260 265 270 Thr His Arg Phe Gly Asp His Val Pro Lys His Val Leu Ile Leu Leu 275 280 285 Ala Asn Leu Tyr Leu Leu Val Pro Pro Thr Met Asn Pro Ile Val Tyr 290 295 300

Page 3741

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Gly Val Lys Thr Lys Glu Ile Arg Met His Val Leu Gly Leu Cys Asn 305 310 315 320

Lys Pro Lys <210> 3347 <211> 942 <212> DNA <213> Felis catus <400> 3347

ctacattttc agggaacacc acttcttcat cctgcttcgg atctgctggg tctttacact 60 gtagatgatt ggattcatca ggggtggaaa gagaatatag atgttgccca tgaggacatg 120 aacggaaggg gagagatgct ttccaaagcg atgcaccatg gtgaggccaa tgatggggat 180 gtaaaagacc aggacagcac agatgtggga cacacaggtc tgcaaggact tgagcctctc 240 ctcgcgggat gcaattgcca gcactgtgtg caagatgaaa acgtaggaga tgagaataag 300 cacagcgtct aacaacaagg tacagatcac cagagccaag gcatagaggc tgttgaagcg 360 gatgtcagag caggcgagcc ggagcaggtc ctggtgcagg cagaaagagt gggagaggat 420 gtgagggcgg cagtaatgga agagcttcag gcgaatgatg acagggagaa tggacaaagc 480 tgccctcatc aaaatggcca ccatgaagtg aatgactcta ctgttagtca ggagggatgt 540 gtatctcaga ggattgcaga ttgcagtgaa gcgatcaaag gccatggcaa gaaggacccc 600 agactctatg gaggacagac catggataaa gtaagtttgg gcaatgcaag catcttgact 660 aacttcttgg ttgagccccc acaggacccc cagcaccgtg tgcactgtgg acagccccat 720 gcacaggtca gtgagagcca gcatggccag gaagtagaac atgggctggt gcaggctggg 780 ctctgtccgg atcacatgca gcaccacgca gtttcccagg aaaaccatgg catagatgga 840 ggagaaggga atggaaaacc agggatagta gtggtccagg ccagggaacc ccgtgagaat 900 gaatattgag gtattgataa tggaagcaga agaagcaggc at 942

<210> 3348 <211> 313 <212> PRT <213> Felis catus

Page 3742

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<400> 3348 Ser Ala Ser Ile Ile Asn Thr Ser Ile Phe Ile Leu 15 Met 1 Pro Ala Ser 5 10 Thr Gly Phe Pro Gly Leu Asp His Tyr Tyr Pro Trp Phe Ser Ile Pro 20 25 30 Phe Ser Ser Ile Tyr Ala Met Val Phe Leu Gly Asn Cys Val Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Val 65 70 75 80 His Thr Val Leu Gly Val Leu Trp Gly Leu Asn Gln Glu Val Ser Gln 85 90 95 Asp Ala Cys Ile Ala Gln Thr Tyr Phe Ile His Gly Leu Ser Ser Ile 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Phe Asp Arg Phe Thr Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Thr Ser Leu Leu Thr Asn Ser Arg Val Ile 130 135 140 His Phe Met Val Ala Ile Leu Met Arg Ala Ala Leu Ser Ile Leu Pro 145 150 155 160 Val Ile Ile Arg Leu Lys Leu Phe His Tyr Cys Arg Pro His Ile Leu 165 170 175 Ser His Ser Phe Cys Leu His Gln Asp Leu Leu Arg Leu Ala Cys Ser 180 185 190 Asp Ile Arg Phe Asn Ser Leu Tyr Ala Leu Ala Leu Val Ile Cys Thr 195 200 205

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Leu Leu Leu Asp Ala Val Leu Ile Leu Ile Ser Tyr Val Phe Ile Leu 210 215 220 His Thr Val Leu Ala Ile Ala Ser Arg Glu Glu Arg Leu Lys Ser Leu 225 230 235 240 Gln Thr Cys Val Ser His Ile Cys Ala Val Leu Val Phe Tyr Ile Pro 245 250 255 Ile Ile Gly Leu Thr Met Val His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Ser Val His Val Leu Met Gly Asn Ile Tyr Ile Leu Phe Pro Pro Leu 275 280 285 Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Gln Gln Ile Arg Ser Arg 290 295 300 Met Lys Lys Trp Cys Ser Leu Lys Met

305 310

<210> 3349 <211> 910 <212> DNA <213> Felis catus <400> 3349 gtctctgatg ccagccccac ccagccagaa gaggcttagc atcctcagcc ggatctgctt 60 ggtcttaatg gtgtagacat tgacaccgga ggcgtgagaa aatgaagaca ggagagcagc 120 acacggctgg aaggggaagc ccccttccca aatctgtgga tcatggacag gccaatgata 180 ggcgtgtaga agagcaacac agcacagaca aaggcgacac aagtgttgag ggctttgagg 240 cgctcaacat tggaagcaat ggatagcatt gtttggagat cagcccatag tagagcacaa 300 tgagcatcac aaagagacca taggcactgt tgatgtgggt gtctgcacag gccagcatga 360 catctgggtg tagacagtaa gagggggaaa gcaggtgatt ctggcagtaa ggcagctcct 420 tcagcatgat gggggccggg atgtggagcc cgaagctgtg cgccacactg gccaggccca 480 agcaggcaat gtgggagctg gtgagcatgg tgctgtaacg cagggggttg ctaatggcca 540

Page 3744

069269_0225_SL.TXT caaaatggtc aaaggccatg gtcagcagca cagaggactc catgagggag aaagtgtgga tgaagaagag ctgggccagg cacatatcca ccgccacctg tctgagaccc agcatgtaga aggggagcat ggtggagggg agcgtggagg cagacaggcc caggtcagtc gctgtcagca tcgacaggaa gtagtacatg ggctggtgca gagtgggctc tgacttcacc acccacagga tcaggctgtt ccctgccaga gaggccacgt acatggcaca cagagggatg gagagccagc tgtgcacagc ctcaaggcct gggagccctg ctaggaggaa ggaactacca gtgtggttgg agtctgacat

600

660

720

780

840

900

910 <210> 3350 <211> 249 <212> PRT <213> Felis catus

<400> 3350 His Thr Gly Ser Ser Phe Leu Leu Ala Gly Leu Met 1 Ser Asp Ser Asn 5 10 15 Pro Gly Leu Glu Ala Val His Ser Trp Leu Ser Ile Pro Leu Cys Ala 20 25 30 Met Tyr Val Ala Ser Leu Ala Gly Asn Ser Leu Ile Leu Trp Val Val 35 40 45 Lys Ser Glu Pro Thr Leu His Gln Pro Met Tyr Tyr Phe Leu Ser Met 50 55 60 Leu Thr Ala Thr Asp Leu Gly Leu Ser Ala Ser Thr Leu Pro Ser Thr 65 70 75 80 Met Leu Pro Phe Tyr Met Leu Gly Leu Arg Gln Val Ala Val Asp Met 85 90 95 Cys Leu Ala Gln Leu Phe Phe Ile His Thr Phe Ser Leu Met Glu Ser 100 105 110 Ser Val Leu Leu Thr Met Ala Phe Asp His Phe Val Ala Ile Ser Asn 115 120 125

Page 3745

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Pro Leu 130 Arg Tyr Ser Gly 145 Leu Ala Ser Val Ile Met Leu Lys Glu 165 Ser Tyr Cys Leu 180 His Ile Asn Ser 195 Ala Tyr Gly Leu 210 Ile Ser Lys Ser 225 Lys Pro Ser Thr Ser Thr Arg Leu Ser 245

Thr Met 135 Leu Thr Ser Ser Ala 150 His Ser Phe Gly Leu 155 Leu Pro Tyr Cys Gln 170 Asn Pro Asp Val Met 185 Leu Ala Gly Leu Phe 200 Val Met Leu Gln Cys 215 Tyr Pro Leu Leu Leu 230 Val Ser Pro Leu Ser 235 Leu Ala Cys Pro

His 140 Ile Ala Cys Leu His Ile Pro Ala Pro 160 His Leu Leu Ser 175 Pro Cys Ala Asp 190 Thr His Ile Val 205 Leu Tyr Tyr Pro 220 Met Leu Ser Ala Val Leu Cys Cys Ser

240 <210> 3351 <211> 942 <212> DNA <213> Felis catus <400> 3351 tcagagtttt tttaggtgga accgtagaca attgggttga gtatatacct gagctggtag agtggggtat aaaatagtaa agcccctcag tgttagaaga agaatgagta cagcatccaa gcgtcttcag aatgcatgcc gcattagagg aacaagaaag cttctttttc ccaaagtgat tacagcacag ctgtgggaaa aatgctcaat actgtcctca agccagtgtg gagagcatga cgaatctctt tggttttaac tgtagatagg agagaaacat ggatcatcga caggctgacc tgcaggtgtt aaaggcttgg agattagcat gtaggagagg caaagagccc aaagccactg

120

180

240

300

360

Page 3746

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tccacaagag tgctagaact ggctagcctt aaaacatcag gatgaacaca atatgaatga 420 gacagagcat tcataggctg aaattgccgt cttccaagga tcaagaacag gggcagatgg 480 agagcagcac tacgtatcac aatggccagc ccaatggccc caatgcgctt ggttgtgaga 540 atggtggcat agcataaaag ctctcgaata gccacatggt ggtcaaaagc catggccaag 600 agcacagatg attcaataac tgagaaagta tggatgaaga agagttgtgt aaagcaggtt 660 gcatctccca cctctctctg gcccaggaca aagacagctg tcactgaagg cagggtggaa 720 gctgagaggc ccaggtctgc cattgaaagc atggacagga agaggtacct aggtgtgtgg 780 aggctaggga caggcttgac aatgtacatt atggtgattt tgcccagcaa agacacaaca 840 tagatagagc agataggaat agctgtccag cagtgagagg tctccagtcc tcttcagtat 900 gaagatgaag ctgctggcat tattgttgtt aagaactgcc at <210> 3352 <211> 52 <212> PRT <213> Felis catus <400> 3352 942 Met Ala Val Leu Asn Asn Asn Asn Ala Ser Ser Phe Ile Phe Ile Leu 1 5 10 15 Lys Arg Thr Gly Asp Leu Ser Leu Leu Asp Ser Tyr Ser Tyr Leu Leu 20 25 30 Tyr Leu Cys Cys Val Phe Ala Gly Gln Asn His His Asn Val His Cys 35 40 45 Gln Ala Cys Pro 50 <210> 3353 <211> 967 <212> DNA <213> Felis catus <400> 3353 atgttataaa tgtgacttgg gattctcctg gtcttctttc ggtgaagagt ttctgaattt 60 tatctcgtat ctgcttggtt ttcgctacat acacaacagg gttcatcaca gggggaatga 120

Page 3747

069269_0225_SL.TXT gaaaatgcat gttagccatg gtcacgtaga tacatgaggg aagtttgggg ccgaagcggt gcagtatgga caggcagatc atgggtgtga aaaagagaat cacagcacag atgtgggaaa tgcaggtgtt gagagccttg agacggccac cataggatgc aatgctcagt acagttttca gtatcaggac atatgaaaag aggatgaaga gaaaatcaag tcccatagtg gatagcacca caaacagtcc aaagatgctg ttgatcctgg tgttggaaca agagagcttt atgatatcag gatgcaggca gtaggaatga gatagtacat tggaatcaca gaagcacagc gtcctcaaga ggatggggag aggcacctgc acagtgaatg ttcgcactat aatggccaaa cctatcctgg caattacacc gttggtgaga atggaagaat agtgcaatgg acgagaaatg gccacatagc ggtcaaaggc cattgccagt atgatagctg actcaaaatc ctggaaggtg tgaataaaaa acatttgggt gaagcaagca gagaaggtga gctctcgagc atccagccag aagatcccca gcattgtggg gaaagtgaaa agggacagac ccagatcaga gacagctagc atggccagga agagatacat aggcacatgg agggtctggt ccttgcagat aactgttatg atggtcatgt tgctcaccaa ggtaatgaag aacatggcac agaagggtat ggagatccag atgtgcacag cctccagccc aggtatgcct gtcaccacaa aggtggagac tatggatgtg gtgctattgg tgggcaa <210> 3354 <211> 323 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (323)..(323) <223> Any amino acid <400> 3354

180

240

300

360

420

480

540

600

660

720

780

840

900

960

967

Leu Pro Thr Asn Ser Thr Thr Ser Ile Val Ser Thr Phe Val Val Thr 1 5 10 15 Gly Ile Pro Gly Leu Glu Ala Val His Ile Trp Ile Ser Ile Pro Phe

20 25 30

Page 3748

Cys Ala Met 35 Phe Phe Ile Thr 069269_0225_SL.TXT Leu Val Ser Asn Met Thr 40 45 Ile Ile Thr Val Ile Cys Lys Asp Gln Thr Leu His Val Pro Met Tyr Leu Phe Leu 50 55 60 Ala Met Leu Ala Val Ser Asp Leu Gly Leu Ser Leu Phe Thr Phe Pro 65 70 75 80 Thr Met Leu Gly Ile Phe Trp Leu Asp Ala Arg Glu Leu Thr Phe Ser 85 90 95 Ala Cys Phe Thr Gln Met Phe Phe Ile His Thr Phe Gln Asp Phe Glu 100 105 110 Ser Ala Ile Ile Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Ser 115 120 125 Arg Pro Leu His Tyr Ser Ser Ile Leu Thr Asn Gly Val Ile Ala Arg 130 135 140 Ile Gly Leu Ala Ile Ile Val Arg Thr Phe Thr Val Gln Val Pro Leu 145 150 155 160 Pro Ile Leu Leu Arg Thr Leu Cys Phe Cys Asp Ser Asn Val Leu Ser 165 170 175 His Ser Tyr Cys Leu His Pro Asp Ile Ile Lys Leu Ser Cys Ser Asn 180 185 190 Thr Arg Ile Asn Ser Ile Phe Gly Leu Phe Val Val Leu Ser Thr Met 195 200 205 Gly Leu Asp Phe Leu Phe Ile Leu Phe Ser Tyr Val Leu Ile Leu Lys 210 215 220 Thr Val Leu Ser Ile Ala Ser Tyr Gly Gly Arg Leu Lys Ala Leu Asn 225 230 235 240

Page 3749

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Thr Cys Ile Ser His 245 Ile Cys Ala Val Ile Leu Phe Phe Thr Pro Met 250 255 Ile Cys Leu Ser Ile Leu His Arg Phe Gly Pro Lys Leu Pro Ser Cys 260 265 270 Ile Tyr Val Thr Met Ala Asn Met His Phe Leu Ile Pro Pro Val Met 275 280 285 Asn Pro Val Val Tyr Val Ala Lys Thr Lys Gln Ile Arg Asp Lys Ile 290 295 300 Gln Lys Leu Phe Thr Glu Arg Arg Pro Gly Glu Ser Gln Val Thr Phe 305 310 315 320 Ile Thr Xaa

<210> 3355 <211> 957 <212> DNA <213> Felis catus <400> 3355

atgttggctt ttaataacac tttctttaat tggcccactt tctccttcat tggtattcct 60 ggtctggaag ctgcacatat atggatctcc atccccttct gtgtcctgta cctcatagcc 120 cttgtgggta atgctgttct tcttatccta gttagagcag agaagaacct tcatgaacct 180 cagttctatt ttttggctat gctagccctt actgatctag gcctttcatt gtcaacaatg 240 cctagtgtct tggctatctt ctggtttgat gtccgtgaca ttggccttaa tgcctgccta 300 acccagatgt tcttcatcca caccctctcc tcagtagaat caggtgtcct ggtggccatg 360 gcttttgacc gtttggtagc tatctgtgct ccactaaact ataccaagat ccttacccac 420 tacaccgttg cctgccttag tggagctgcc ctcatacgag gtgccactct gctggctcct 480 ctgccttttt tccttaggac ttttcctttc tgtggggcca atatcctgtc acactcctat 540 tgctactacc cagatatgct gaacttagcc tgtggggaca ttaccttcag cagtgcctat 600 ggattggttt ttgttctctg cacatttgca gtggatgttg tcttcatctt agcttcatac 660

Page 3750

069269_0225_SL.TXT atgaagatct tggacaccat tatgaagctg gagactcaag acagaaactg gaggtcactg cacacctgtg cctgtcacct atgcatggtg cttgtgttct acctgcccct aatcagcttg gcagtgctac atcgttatac ccaggacact tccccaattc tgtataccac catgagtaat gcctacctcc tcatgacacc actgctcaac cctctcgtct atagtctcaa atcccggcag atccaggctg ccctgcgcaa gcgattttgg gtgcaacgtg tcattgctgg ggaatga

720

780

840

900

957 <210> 3356 <211> 318 <212> PRT <213> Felis catus <400> 3356

Met 1 Leu Ala Phe Asn Asn Thr Phe Phe Asn Trp Pro Thr Phe Ser Phe 5 10 15 Ile Gly Ile Pro Gly Leu Glu Ala Ala His Ile Trp Ile Ser Ile Pro 20 25 30 Phe Cys Val Leu Tyr Leu Ile Ala Leu Val Gly Asn Ala Val Leu Leu 35 40 45 Ile Leu Val Arg Ala Glu Lys Asn Leu His Glu Pro Gln Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Gly Leu Ser Leu Ser Thr Met 65 70 75 80 Pro Ser Val Leu Ala Ile Phe Trp Phe Asp Val Arg Asp Ile Gly Leu 85 90 95 Asn Ala Cys Leu Thr Gln Met Phe Phe Ile His Thr Leu Ser Ser Val 100 105 110 Glu Ser Gly Val Leu Val Ala Met Ala Phe Asp Arg Leu Val Ala Ile 115 120 125 Cys Ala Pro Leu Asn Tyr Thr Lys Ile Leu Thr His Tyr Thr Val Ala 130 135 140

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Cys Leu Ser Gly Ala Ala Leu Ile Arg Gly Ala Thr Leu Leu Ala Pro 145 150 155 160 Leu Pro Phe Phe Leu Arg Thr Phe Pro Phe Cys Gly Ala Asn Ile Leu 165 170 175 Ser His Ser Tyr Cys Tyr Tyr Pro Asp Met Leu Asn Leu Ala Cys Gly 180 185 190 Asp Ile Thr Phe Ser Ser Ala Tyr Gly Leu Val Phe Val Leu Cys Thr 195 200 205 Phe Ala Val Asp Val Val Phe Ile Leu Ala Ser Tyr Met Lys Ile Leu 210 215 220 Asp Thr Ile Met Lys Leu Glu Thr Gln Asp Arg Asn Trp Arg Ser Leu 225 230 235 240 His Thr Cys Ala Cys His Leu Cys Met Val Leu Val Phe Tyr Leu Pro 245 250 255 Leu Ile Ser Leu Ala Val Leu His Arg Tyr Thr Gln Asp Thr Ser Pro 260 265 270 Ile Leu Tyr Thr Thr Met Ser Asn Ala Tyr Leu Leu Met Thr Pro Leu 275 280 285 Leu Asn Pro Leu Val Tyr Ser Leu Lys Ser Arg Gln Ile Gln Ala Ala 290 295 300 Leu Arg Lys Arg Phe Trp Val Gln Arg Val Ile Ala Gly Glu 305 310 315 <210> 3357 <211> 834 <212> DNA <213> Felis catus <400> 3357 aaacagtcta cattttggac ttcaaatttg ttttcttttc acactagaaa caaaagagtt 60

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gaggacaggt gtgaggaaaa ggataatgtt ggacatagtg atgtggggta aaggggagtt 120 gtatctgcct gtcctgtgga tcagaactaa gccaataagt gggtcctaga caatgaggac 180 catgacaatg tggtagacat gtgtgttgag ttccttaagt catccttccc cagaagcaat 240 gccaagaact gtcttcaaga tcaaagcata agacagaaac aataaagaca gagtcaacac 300 caaaggtgca gagaaccaat gccaacccat gggtgatgtt cacatgaatg gacacacaag 360 ctagcttcat cacttcaggg tggaagcaga atgagtggga taggatgatg ttcttacaga 420 agggaagcca tttgagctgg atgagtaaga aggccatcag tgccactcct cgagccatag 480 cagccaatcc cacctgagta atgcaggaat gggtcaggac cacagtgtag catagcgggt 540 tgcatatggc aacaaagcaa tcaaaagcca tggcttacag gagggctgac tccacagaag 600 agaagtgtgg atgaagaacg tcggagctag gcaaccatgg aactcaatcc tgtggttaag 660 gagaaacata ttaggtatag taggcagtgt agatgctgac atgcctgtgt cggtggctgc 720 caacatggat aagaatacat actgaggctc atgaaggctg ggattcttgt gtattatggt 780 aattatgatg cggttctcca ggatggcaat tatatacgtg atgctcagtt ggat 834 <210> 3358 <211> 106 <212> PRT <213> Felis catus <400> 3358 Ile Gln Leu Ser Ile Thr Tyr Ile Ile Ala Ile Leu Glu Asn Arg Ile 1 5 10 15 Ile Ile Thr Ile Ile His Lys Asn Pro Ser Leu His Glu Pro Gln Tyr 20 25 30 Val Phe Leu Ser Met Leu Ala Ala Thr Asp Thr Gly Met Ser Ala Ser 35 40 45 Thr Leu Pro Thr Ile Pro Asn Met Phe Leu Leu Asn His Arg Ile Glu 50 55 60 Phe His Gly Cys Leu Ala Pro Thr Phe Phe Ile His Thr Ser Leu Leu 65 70 75 80

Page 3753

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Trp Ser Gln Pro Ser Cys Lys Pro Trp Leu Leu Ile Ala Leu Leu Pro 85 90 95

Tyr Ala Thr Arg Tyr Ala Thr Leu Trp Ser 100 105 <210> 3359 <211> 946 <212> DNA <213> Felis catus <400> 3359

ctacttcagc aagtttctcc tggccctgag taccttgtgt actgcagacc ttatctgttt 60 ggtttttagg ctataaacca agggattaag gactggggtc aagaagagaa agagattggc 120 catggtgaca tggagaagag gagatgtgaa tgtaccaaac ctatgaatta gagccaggac 180 aatgagtggc acataaaaga tgcagacagt gaaaatgtgg gaaatgcaag tattaagcgc 240 tctgagctga ccatcttctg aagcaatacc cagcactgtt ttcaaaataa ggatgtatga 300 aatgacaatg aacacagagt caactccaaa ggagcagagc acaagagaca gtccatagat 360 gatattgact ctgacagggc cacaggccag cttcataaca tcagggtggt agcagtaaca 420 atgtgatagg ataacatccc tgcagaaaga caatcgcttg agcaggattg gcaagggtac 480 catcaacacc acagccctaa ccatggctgc aattcccatc cccatgatcc gaggagaggt 540 taagaccaca gtgtagtgca atgggttgca aatagctaca aatcggtcaa aggccatggc 600 caacaggatg gctgactcca tggaggagaa ggtatggatg aagaacattt gtgtcagaca 660 agaatggaac tcaatttctc tgtgattcaa gaggaagaca ctgagtaccg taggtagagt 720 tgataaagac agacccacat ctgtggttgc cagcatcgat aggaagatgt attgagggtc 780 atgaaggctg gaggtggttt tgataacaaa gaggatgatg cagttcccca ggagagcaat 840 tagatacatg acacacagtg ggatagagat ccatatttgt acagcctcca gtccaggaat 900 gcctgttagg agaagagtgg gtggctggaa ccagctactg tttata 946

<210> 3360 <211> 314 <212> PRT

Page 3754

069269_0225_SL.TXT <213> Felis catus <400> 3360

Ile Asn Ser Ser Trp Phe Gln Pro Pro Thr Leu Leu Leu Thr Gly Ile 1 5 10 15 Pro Gly Leu Glu Ala Val Gln Ile Trp Ile Ser Ile Pro Leu Cys Val 20 25 30 Met Tyr Leu Ile Ala Leu Leu Gly Asn Cys Ile Ile Leu Phe Val Ile 35 40 45 Lys Thr Thr Ser Ser Leu His Asp Pro Gln Tyr Ile Phe Leu Ser Met 50 55 60 Leu Ala Thr Thr Asp Val Gly Leu Ser Leu Ser Thr Leu Pro Thr Val 65 70 75 80 Leu Ser Val Phe Leu Leu Asn His Arg Glu Ile Glu Phe His Ser Cys 85 90 95 Leu Thr Gln Met Phe Phe Ile His Thr Phe Ser Ser Met Glu Ser Ala 100 105 110 Ile Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile Cys Asn Pro 115 120 125 Leu His Tyr Thr Val Val Leu Thr Ser Pro Arg Ile Met Gly Met Gly 130 135 140 Ile Ala Ala Met Val Arg Ala Val Val Leu Met Val Pro Leu Pro Ile 145 150 155 160 Leu Leu Lys Arg Leu Ser Phe Cys Arg Asp Val Ile Leu Ser His Cys 165 170 175 Tyr Cys Tyr His Pro Asp Val Met Lys Leu Ala Cys Gly Pro Val Arg 180 185 190 Val Asn Ile Ile Tyr Gly Leu Ser Leu Val Leu Cys Ser Phe Gly Val

Page 3755

195 069269_0225_SL.TXT 200 205 Asp Ser Val Phe Ile Val Ile Ser Tyr Ile Leu Ile Leu Lys Thr Val 210 215 220 Leu Gly Ile Ala Ser Glu Asp Gly Gln Leu Arg Ala Leu Asn Thr Cys 225 230 235 240 Ile Ser His Ile Phe Thr Val Cys Ile Phe Tyr Val Pro Leu Ile Val 245 250 255 Leu Ala Leu Ile His Arg Phe Gly Thr Phe Thr Ser Pro Leu Leu His 260 265 270 Val Thr Met Ala Asn Leu Phe Leu Phe Leu Thr Pro Val Leu Asn Pro 275 280 285 Leu Val Tyr Ser Leu Lys Thr Lys Gln Ile Arg Ser Ala Val His Lys 290 295 300 Val Leu Arg Ala Arg Arg Asn Leu Leu Lys

305 310 <210> 3361 <211> 840 <212> DNA <213> Felis catus <400> 3361

cccatctgtt tcatgtacat agtttctgtt ttaggcaaca ccttcttatt attcctgatc 60 ttcactgaac gcagtcttca tgaacccatg taccttttct tgtccatgtt agccctggca 120 gatatctttc tctccacagt caccacacca aagatgctag caatcttctg gttccaagat 180 gggggtattt cttttggttg ctgtgtgtcc caaatgtttt ttctccactt catctttgtg 240 gcagagtctg ccatattgct ggccatggca tttgaccgct atgtagccat ctgccatcca 300 ctaagatata ctacaattct aaccccctca gtcattggaa aaatgggcat tgcctctgtg 360 atcaggagtt tcttcatctg cttccccttg gtttttctgg tttatcggct tgcttactgt 420 gggaggaata ttattcatca ctcatattgt gaacatatgg gcattgccag gctagcctgt 480

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gatagcatca aaatcaacat ctactatggg gtgattgtgg ccctattttc tacatgcctg 540 gatgtggtgt ttatcattgt ttcctatgcc cttatactct gtactgtttt tagaattcct 600 tcccaagatg cccgactcaa gactctgggt acttgtggct cccatgtctg tgttatcctg 660 ctgttctata ctccagcctt tttttcattc tttgctcacc gatttggggg ccaccatata 720 ccactccatg tacatatcct ccttgccaat ctttatgtgg tggtaccacc cactctcaat 780 cccatcattt atggagttaa gaccaagaaa gttcaggaga agtttgtcca tgtcttttct 840

<210> 3362 <211> 280 <212> PRT <213> Felis catus <400> 3362

Pro Ile Cys Phe Met Tyr Ile Val Ser Val Leu Gly Asn Thr Phe Leu 1 5 10 15 Leu Phe Leu Ile Phe Thr Glu Arg Ser Leu His Glu Pro Met Tyr Leu 20 25 30 Phe Leu Ser Met Leu Ala Leu Ala Asp Ile Phe Leu Ser Thr Val Thr 35 40 45 Thr Pro Lys Met Leu Ala Ile Phe Trp Phe Gln Asp Gly Gly Ile Ser 50 55 60 Phe Gly Cys Cys Val Ser Gln Met Phe Phe Leu His Phe Ile Phe Val 65 70 75 80 Ala Glu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 85 90 95 Ile Cys His Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro Ser Val Ile 100 105 110 Gly Lys Met Gly Ile Ala Ser Val Ile Arg Ser Phe Phe Ile Cys Phe 115 120 125

Page 3757

Pro Leu 130 Val Phe Leu Val Tyr 135 069269_0225_SL.TXT Arg Leu Ala Tyr Cys Gly 140 Arg Asn Ile Ile His His Ser Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys 145 150 155 160 Asp Ser Ile Lys Ile Asn Ile Tyr Tyr Gly Val Ile Val Ala Leu Phe 165 170 175 Ser Thr Cys Leu Asp Val Val Phe Ile Ile Val Ser Tyr Ala Leu Ile 180 185 190 Leu Cys Thr Val Phe Arg Ile Pro Ser Gln Asp Ala Arg Leu Lys Thr 195 200 205 Leu Gly Thr Cys Gly Ser His Val Cys Val Ile Leu Leu Phe Tyr Thr 210 215 220 Pro Ala Phe Phe Ser Phe Phe Ala His Arg Phe Gly Gly His His Ile 225 230 235 240 Pro Leu His Val His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro 245 250 255 Pro Thr Leu Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Lys Val Gln 260 265 270 Glu Lys Phe Val His Val Phe Ser

275 280 <210> 3363 <211> 940 <212> DNA <213> Felis catus <400> 3363 attttttgaa attaaacaat ctctgaactc ttcttcgtat ttgttgggtc ttgatactgt aaataatggg gttcatcaag ggtgggaaaa ggatataggt gttgcccagg aggacatgta cccatggtga gaggtgtttc ccaaagcgat gcaccatagt cagaccaatg attgggatgt

120

180

Page 3758

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agaaaacaga aacagcacag atgtgagata cacaggtctg caaggacttg attctctctt 240 cccgtgatgc aatagctaag actgcatgca agatcataat ataggagata agtatgagca 300 ctgcatccaa caacaggttg ctaattacca gggcaagacc ataaatgctg ttgaaacgga 360 tgtctgaaca ggccattcta attaagtctt ggtgcaggca gaaagagtga gaaaggatgt 420 gggggcggca ataatttaag aactttaggc gaatgatgac tggaggtatg agtaaagaac 480 tcctacataa gattgtcacc ccaattttca tgattttgtc attagttagg atggaagaat 540 agcgtagtgg gttgcaaatg gcaatgtaac ggtcaaaagc catagcaagg aggacagagg 600 attccatgaa ggacaaacca tggatgaagt aggactgggc aatgcaggaa tctaggctga 660 tctcacgaac gaatccccac aggatcccca gaaccgtgta catggtagac agccccatgc 720 acagatcagt gagggccagc atggccagga agtagaacat aggctggtgc aggctgggct 780 ctgtccggat cacatgcagc accatgcagt ttcccaggaa aaccgtggca tagatggagg 840 agaaagggat ggagatccag agatagtgaa cttctaggcc aggaaaacca gtgagaataa 900 atctggaact attaacatta aagatagaga taggagacat 940

<210> 3364 <211> 314 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (314)..(314) <223> Any amino acid

<400> 3364 Met 1 Ser Pro Ile Ser Ile Phe Asn Val Asn Ser Ser Arg Phe Ile Leu 5 10 15 Thr Gly Phe Pro Gly Leu Glu Val His Tyr Leu Trp Ile Ser Ile Pro 20 25 30 Phe Ser Ser Ile Tyr Ala Thr Val Phe Leu Gly Asn Cys Met Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met Phe Tyr Phe Page 3759

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50 55 60

Leu Ala Met 65 Leu Ala Leu 70 Thr Asp Leu Cys Met Gly Leu Ser Thr Met 75 80 Tyr Thr Val Leu Gly Ile Leu Trp Gly Phe Val Arg Glu Ile Ser Leu 85 90 95 Asp Ser Cys Ile Ala Gln Ser Tyr Phe Ile His Gly Leu Ser Phe Met 100 105 110 Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Ile Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ser Ser Ile Leu Thr Asn Asp Lys Ile Met 130 135 140 Lys Ile Gly Val Thr Ile Leu Cys Arg Ser Ser Leu Leu Ile Pro Pro 145 150 155 160 Val Ile Ile Arg Leu Lys Phe Leu Asn Tyr Cys Arg Pro His Ile Leu 165 170 175 Ser His Ser Phe Cys Leu His Gln Asp Leu Ile Arg Met Ala Cys Ser 180 185 190 Asp Ile Arg Phe Asn Ser Ile Tyr Gly Leu Ala Leu Val Ile Ser Asn 195 200 205 Leu Leu Leu Asp Ala Val Leu Ile Leu Ile Ser Tyr Ile Met Ile Leu 210 215 220 His Ala Val Leu Ala Ile Ala Ser Arg Glu Glu Arg Ile Lys Ser Leu 225 230 235 240 Gln Thr Cys Val Ser His Ile Cys Ala Val Ser Val Phe Tyr Ile Pro 245 250 255

Ile Ile Gly Leu Thr Met Val His Arg Phe Gly Lys His Leu Ser Pro Page 3760

260

069269_0225_SL.TXT 265 270

Trp Val His Val Leu Leu Gly Asn Thr Tyr Ile Leu Phe Pro Pro Leu 275 280 285 Met Asn Pro Ile Ile Tyr Ser Ile Lys Thr Gln Gln Ile Arg Arg Arg 290 295 300 Val Gln Arg Leu Phe Asn Phe Lys Lys Xaa 305 310

<210> 3365 <211> 952 <212> DNA <213> Felis catus <400> 3365

atgctcaagc tcaatggcac agtcttcatg ccctcagtgc tgacactggt tgggatccct 60 ggcttggaat ctgtgcagtt ctggattgga attcctttct gtgccatgta catcactgct 120 ctgtttggga attccctgct cctggtcatc atcaaatcgg aacgcagcct ccatgagccc 180 atgtacctct tcctggcaat gcttggagca acagacattg ctctcagtac ctgcatccta 240 cccaaaatgc taggaatatt ctggttccat ttaccagaca tatatttcga tgcctgtctc 300 tttcagatgt ggcttatcca caccttccag tgtatcgaat caggaattct gctggccatg 360 gccctggacc gctatgtggc catctgtgat cccctgagac atgcaatcat ctttacccac 420 caactagtca ctcagattgg ggtagcagtg acactcagag cagtcatctt ttcagctcca 480 tgtctcatcc tcatcaaatg tcggctgaaa cacttctgga ccaatgtggt ctcccattca 540 tactgtgagc acatggccgt cgtgaagttg gcagcagaag atattcaaat caacaagatc 600 tatggtctgt ttgtggcttt cattatactt ggatttgaca taatcgttat catactctcc 660 tacatccgaa tatttataac tgtcttcaat ctgcctcaga gagaatctag gctcaaagcc 720 tttaacacct gcattgccca tatttgtgtc ttccttgagt tttatctcct aggtttcttc 780 tccttcttta cacacaggtt cgggttccac attccaccct acattcatat tcttctgtcc 840 aatctttatc tgcttgtccc tcctttgctc aatcctattg tgtatggggt gaaaaccaaa 900 cagattcgag atcggttgtc caagattttt tcactctaag gatccatttt ga 952

Page 3761

069269_0225_SL.TXT <210> 3366 <211> 312 <212> PRT <213> Felis catus

<400> 3366 Gly Thr Val Phe Met Pro Ser Val Leu Thr Leu Met 1 Leu Lys Leu Asn 5 10 15 Val Gly Ile Pro Gly Leu Glu Ser Val Gln Phe Trp Ile Gly Ile Pro 20 25 30 Phe Cys Ala Met Tyr Ile Thr Ala Leu Phe Gly Asn Ser Leu Leu Leu 35 40 45 Val Ile Ile Lys Ser Glu Arg Ser Leu His Glu Pro Met Tyr Leu Phe 50 55 60 Leu Ala Met Leu Gly Ala Thr Asp Ile Ala Leu Ser Thr Cys Ile Leu 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Leu Pro Asp Ile Tyr Phe 85 90 95 Asp Ala Cys Leu Phe Gln Met Trp Leu Ile His Thr Phe Gln Cys Ile 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asp Pro Leu Arg His Ala Ile Ile Phe Thr His Gln Leu Val Thr 130 135 140 Gln Ile Gly Val Ala Val Thr Leu Arg Ala Val Ile Phe Ser Ala Pro 145 150 155 160 Cys Leu Ile Leu Ile Lys Cys Arg Leu Lys His Phe Trp Thr Asn Val 165 170 175

Page 3762

Val Ser His Ser 180 Tyr Cys Glu 069269_0225_SL.TXT His Met Ala Val Val Lys 185 Leu 190 Ala Ala Glu Asp Ile Gln Ile Asn Lys Ile Tyr Gly Leu Phe Val Ala Phe Ile 195 200 205 Ile Leu Gly Phe Asp Ile Ile Val Ile Ile Leu Ser Tyr Ile Arg Ile 210 215 220 Phe Ile Thr Val Phe Asn Leu Pro Gln Arg Glu Ser Arg Leu Lys Ala 225 230 235 240 Phe Asn Thr Cys Ile Ala His Ile Cys Val Phe Leu Glu Phe Tyr Leu 245 250 255 Leu Gly Phe Phe Ser Phe Phe Thr His Arg Phe Gly Phe His Ile Pro 260 265 270 Pro Tyr Ile His Ile Leu Leu Ser Asn Leu Tyr Leu Leu Val Pro Pro 275 280 285 Leu Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 Arg Leu Ser Lys Ile Phe Ser Leu 305 310

<210> 3367 <211> 955 <212> DNA <213> Felis catus <400> 3367 ttagttttca gaaatcttct tgcttgggaa gaagagacca accactcggt cacgaatctg cttggtcttg acgccataca ccaggggatt gactgcagga ggcaccaaaa gatacaaact cgcaaaaatt atatgaatgc ttggaggtac cttcttgcca atgcggtgag ttaggaaact aaacagtgca ggggtgtagg agacaagtat agtgcacaca tgggcagcac aggtgcccag cgctttcgag cgggcattct gggaagacag ctggaagact gcctggagga ttttggtata

120

180

240

300

Page 3763

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ggatgcggct atgagcccta ggtcccacac catcactgaa agggccacag agattccgta 360 cactctgtta atgagggtgt tggcactggc caacttcacc acagccatgt gctcacagta 420 ggcatgactg atgacatatt tagtataata tggtagcctt ttaataagaa gaggacctgg 480 aaaaaccata aggatagctc gggtcatacc agctagaccc attttaatga ccgttggtgt 540 tgtcaggatg gttgtataac gcaatgggat acaaatagct acatagcggt caaaggccat 600 ggcaaccaag agggatgatt caattacgca gaatgtgtga atgaaataca actgtgtcag 660 gcaggtgtca aagtcaatcc aatgtgcatc catccagaag ataccaagca tcttgggggc 720 cgtggaagag gcaagagcca tgtcattcac tgccagcata caaaggaaga aatacatagg 780 ctggtggagg cttggttcta gtttgatggt gatgatgatt acactgttcc ccagcagggc 840 cagggcaagc agggaggcag accgggatgc caatccagca gtgaaaatct tgcaaaccag 900 gaataccaac caggaaaaaa gatgagatgt agcgatgtgt agcattgtct gccat 955

<210> 3368 <211> 314 <212> PRT <213> Felis catus <400> 3368

Met 1 Leu His Ile Ala 5 Thr Ser His Leu Phe Ser Trp Leu Val Phe Leu 10 15 Val Cys Lys Ile Phe Thr Ala Gly Leu Ala Ser Arg Ser Ala Ser Leu 20 25 30 Leu Ala Leu Ala Leu Leu Gly Asn Ser Val Ile Ile Ile Thr Ile Lys 35 40 45 Leu Glu Pro Ser Leu His Gln Pro Met Tyr Phe Phe Leu Cys Met Leu 50 55 60 Ala Val Asn Asp Met Ala Leu Ala Ser Ser Thr Ala Pro Lys Met Leu 65 70 75 80 Gly Ile Phe Trp Met Asp Ala His Trp Ile Asp Phe Asp Thr Cys Leu 85 90 95

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Thr Gln Leu Tyr 100 Phe Ile His Thr Phe Cys Val Ile Glu Ser Ser Leu 105 110 Leu Val Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Ile Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Leu Thr Thr Pro Thr Val Ile Lys Met Gly Leu 130 135 140 Ala Gly Met Thr Arg Ala Ile Leu Met Val Phe Pro Gly Pro Leu Leu 145 150 155 160 Ile Lys Arg Leu Pro Tyr Tyr Thr Lys Tyr Val Ile Ser His Ala Tyr 165 170 175 Cys Glu His Met Ala Val Val Lys Leu Ala Ser Ala Asn Thr Leu Ile 180 185 190 Asn Arg Val Tyr Gly Ile Ser Val Ala Leu Ser Val Met Val Trp Asp 195 200 205 Leu Gly Leu Ile Ala Ala Ser Tyr Thr Lys Ile Leu Gln Ala Val Phe 210 215 220 Gln Leu Ser Ser Gln Asn Ala Arg Ser Lys Ala Leu Gly Thr Cys Ala 225 230 235 240 Ala His Val Cys Thr Ile Leu Val Ser Tyr Thr Pro Ala Leu Phe Ser 245 250 255 Phe Leu Thr His Arg Ile Gly Lys Lys Val Pro Pro Ser Ile His Ile 260 265 270 Ile Phe Ala Ser Leu Tyr Leu Leu Val Pro Pro Ala Val Asn Pro Leu 275 280 285 Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp Arg Val Val Gly Leu 290 295 300

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Phe Phe Pro Ser Lys Lys Ile Ser Glu Asn 305 310 <210> 3369 <211> 939 <212> DNA <213> Felis catus <400> 3369

ttatgaagag aacatcttta ccacatgaat gcggatctgc ttggtcttgg caccatagac 60 gagtggattg agaaatgggg ggaccagcaa gtagaggcta gaaaagagga tgtggatata 120 agggggaaca tgagcaccaa acctatgtgt gaagaaggag aagaaggcaa ggaggtagaa 180 ctggaggaag acacagatgt gagcgatgca cgtattgaat gctttcaaac gagcctcctt 240 ctggggcaaa cgaaaaactg tgaaaaagat ctgtgcataa gacaaagtga tgaatgtgag 300 gtcgaaccct gcaactataa atgccacaaa caaaccatag attttgttga cccgtacatt 360 ttctgcagcc agtttcacaa tggccatatg ctcacagtag cagtgggaga tgatggttgt 420 atggtaaaac tgaaaccgga actttatcag tactaaagat ggggctacaa gaagggcagc 480 cctgagtgtt accacagccg ctatttgggt gactaggtgg tgggtgaaga tggcagaatg 540 tcttagtgga taacagatgg ccacataacg gtccagagcc atggccaaca ggatgcctga 600 ctctatgcct tgaaatgtgt ggatgagccc catttgaagc aaacaggaat caaaataaat 660 gtctggcaca tgaaaccaga agattccaag catcttgggc acaatgctcg tgccaagtac 720 aatatctgtg actcccagca tgcctagaaa aatgtacatg ggctcatgga ggctgcgctc 780 tgacctgatg atgatcagaa gcaagaaatt tccaatgata gcaatgagat acatgacaca 840 gaatggaatc ccaatccagc actgcactgt ctctaggcct gggatcccta tcagtgtcaa 900 cacagaaggc atgaagactg tgatgttgga aacggacat 939

<210> 3370 <211> 312 <212> PRT <213> Felis catus <400> 3370

Met Ser Val Ser Asn Ile Thr Val Phe Met Pro Ser Val Leu Thr Leu 1 5 10 15

Page 3766

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Ile Gly Ile Pro 20 Gly Leu Glu Thr Val Gln Cys Trp Ile Gly Ile Pro 25 30 Phe Cys Val Met Tyr Leu Ile Ala Ile Ile Gly Asn Phe Leu Leu Leu 35 40 45 Ile Ile Ile Arg Ser Glu Arg Ser Leu His Glu Pro Met Tyr Ile Phe 50 55 60 Leu Gly Met Leu Gly Val Thr Asp Ile Val Leu Gly Thr Ser Ile Val 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Val Pro Asp Ile Tyr Phe 85 90 95 Asp Ser Cys Leu Leu Gln Met Gly Leu Ile His Thr Phe Gln Gly Ile 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg His Ser Ala Ile Phe Thr His His Leu Val Thr 130 135 140 Gln Ile Ala Ala Val Val Thr Leu Arg Ala Ala Leu Leu Val Ala Pro 145 150 155 160 Ser Leu Val Leu Ile Lys Phe Arg Phe Gln Phe Tyr His Thr Thr Ile 165 170 175 Ile Ser His Cys Tyr Cys Glu His Met Ala Ile Val Lys Leu Ala Ala 180 185 190 Glu Asn Val Arg Val Asn Lys Ile Tyr Gly Leu Phe Val Ala Phe Ile 195 200 205 Val Ala Gly Phe Asp Leu Thr Phe Ile Thr Leu Ser Tyr Ala Gln Ile 210 215 220

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Phe Phe 225 Thr Val Phe Arg Leu Pro Gln Lys Glu Ala Arg Leu Lys Ala 230 235 240 Phe Asn Thr Cys Ile Ala His Ile Cys Val Phe Leu Gln Phe Tyr Leu 245 250 255 Leu Ala Phe Phe Ser Phe Phe Thr His Arg Phe Gly Ala His Val Pro 260 265 270 Pro Tyr Ile His Ile Leu Phe Ser Ser Leu Tyr Leu Leu Val Pro Pro 275 280 285 Phe Leu Asn Pro Leu Val Tyr Gly Ala Lys Thr Lys Gln Ile Arg Ile 290 295 300 His Val Val Lys Met Phe Ser Ser

305 310 <210> 3371 <211> 946 <212> DNA <213> Felis catus <400> 3371

cctggtcttt ggaacacaac atctttaccg ccttatctcg aatgtgtttg gtcttcaccc 60 catatacaaa gggattgagg aaaggtggaa ccagtaggta aaggttagac aaggtgatat 120 gtacatatga tggaatagaa gatccagatc tgtgagtgaa aaaggaaaaa aaggcaagga 180 gatagaattg gaagaagata catatgtggg gaatacatgt attaagggcc ttaagacgtg 240 cccctttctg ggacaggtga aagacagtga taaatatttg tacataggag agggtgatta 300 aaaggaagtc caggccacca acaataaaag ctccaaggag accgtagaat ttactgatgg 360 aaacgtcttc agtggcaagc ttcacaaggg ccatgtgttc acagtaagtg tgggatatta 420 acttggttcg gtaaagtttc agacgacact ttatgagcaa gaggcatggg attaccaaaa 480 aggcaggcct caaggtcacc ccaattccaa tatgtgtgac cagttgtcga gtgaatatga 540 tagcatgcct cagtggataa cagattgcta catagcggtc cagagccata gccaaaagga 600

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ctcccgattc aataccttga aatgtgtgga taagccacat ctgaaagagg caagcatcaa 660 aatagatctc tggcaagtgg aaccaaaaaa ttccaagcat cttggggaca atgctggtgc 720 taagtacaat gtctgtggct cccaacatgg ccagaaagaa atacataggt tcatggagac 780 tgggttcaga tttgatgatg atcaaaagca gagaatttcc caccaaagca atgatgtaca 840 taacacagaa tggaatccca atccaacact gaatagtttc cagaccaggg atcccaatga 900 aagtcagcac agagggtatg aacatggtgc catttgcaat aggcat 946

<210> 3372 <211> 316 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (316)..(316) <223> Any amino acid <400> 3372

Met Pro Ile Ala Asn Gly Thr Met Phe Ile Pro Ser Val Leu Thr Phe 1 5 10 15

Ile Gly Ile Pro Gly Leu Glu Thr Ile Gln Cys Trp Ile Gly Ile Pro 20 25 30

Phe Cys Val Met Tyr Ile Ile Ala Leu Val Gly Asn Ser Leu Leu Leu 35 40 45

Ile Ile Ile Lys Ser Glu Pro Ser Leu His Glu Pro Met Tyr Phe Phe 50 55 60

Leu Ala Met Leu Gly Ala Thr Asp Ile Val Leu Ser Thr Ser Ile Val 65 70 75 80

Pro Lys Met Leu Gly Ile Phe Trp Phe His Leu Pro Glu Ile Tyr Phe 85 90 95

Asp Ala Cys Leu Phe Gln Met Trp Leu Ile His Thr Phe Gln Gly Ile 100 105 110

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Glu Ser Gly 115 Val Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile 120 125 Cys Tyr Pro Leu Arg His Ala Ile Ile Phe Thr Arg Gln Leu Val Thr 130 135 140 His Ile Gly Ile Gly Val Thr Leu Arg Pro Ala Phe Leu Val Ile Pro 145 150 155 160 Cys Leu Leu Leu Ile Lys Cys Arg Leu Lys Leu Tyr Arg Thr Lys Leu 165 170 175 Ile Ser His Thr Tyr Cys Glu His Met Ala Leu Val Lys Leu Ala Thr 180 185 190 Glu Asp Val Ser Ile Ser Lys Phe Tyr Gly Leu Leu Gly Ala Phe Ile 195 200 205 Val Gly Gly Leu Asp Phe Leu Leu Ile Thr Leu Ser Tyr Val Gln Ile 210 215 220 Phe Ile Thr Val Phe His Leu Ser Gln Lys Gly Ala Arg Leu Lys Ala 225 230 235 240 Leu Asn Thr Cys Ile Pro His Ile Cys Ile Phe Phe Gln Phe Tyr Leu 245 250 255 Leu Ala Phe Phe Ser Phe Phe Thr His Arg Ser Gly Ser Ser Ile Pro 260 265 270 Ser Tyr Val His Ile Thr Leu Ser Asn Leu Tyr Leu Leu Val Pro Pro 275 280 285 Phe Leu Asn Pro Phe Val Tyr Gly Val Lys Thr Lys His Ile Arg Asp 290 295 300 Lys Ala Val Lys Met Leu Cys Ser Lys Asp Gln Xaa

305 310 315

Page 3770

069269_0225_SL.TXT <210> 3373 <211> 898 <212> DNA <213> Felis catus <400> 3373

ttttcagaga aaagagtctg agcattctgc tacgaatctg ctgggtcttg acactgtaga 60 tgatggggtt catcaaaggt ggaaaaagga tgtagatgtt gcccataagt acatggacca 120 caggggagag atgcttgcca aaacggtgca tcattgtgag gctaatgata gggatgtaga 180 acacgagaac agcacaaatg tgggagacac aagtctgaaa tgatttatgc cgctcctcct 240 gagaggcaat taccagcact gacctaagaa tcaggaaata ggagtaaagg atcagaatag 300 catccaacaa tagtgtgaaa atgaccagca tcagggcata gtagctattg aatcttatgt 360 ctgagcaagc gaggcggaga agatcctggt gtaggcagaa tgagtgagag aggatgtggg 420 aatggcagta atggaaaaat ttcagattga tgatgggggg tgtaataaag aagaaactcc 480 tacctactat ggcgagccca attttgaaaa tcctggaatt agtcagaatg gaggaataac 540 gcagtggatt acaaatagca acatacctat caaaggccat cgtaaggaga acagaggact 600 ccatgaagga aagaccatgg ataaaatagg actgggcaat gcaggaattc aggctgattt 660 ctcgaatgaa cccccacagg atccccagca ctgtgtggaa tgtggacagc cccatgcaca 720 ggtcagtgag ggccagcatg gccaggaagt agaacatggg ttggtgcagg ctgggctctg 780 tccggatcac atgtagcacc atgcagttgc ccgaaagcac catggcatag atggtcaaaa 840 agggaatgga gatccaggga tactgctgct ccaggccaga aaatccagtg agaagaaa 898

<210> 3374 <211> 300 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (300)..(300) <223> Any amino acid <400> 3374

Phe Leu Leu Thr Gly Phe Ser Gly Leu Glu Gln Gln Tyr Pro Trp Ile 1 5 10 15

Page 3771

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Ser Ile Pro Phe 20 Leu Thr Ile Tyr Ala Met Val Leu Ser Gly Asn Cys 25 30 Met Val Leu His Val Ile Arg Thr Glu Pro Ser Leu His Gln Pro Met 35 40 45 Phe Tyr Phe Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu 50 55 60 Ser Thr Phe His Thr Val Leu Gly Ile Leu Trp Gly Phe Ile Arg Glu 65 70 75 80 Ile Ser Leu Asn Ser Cys Ile Ala Gln Ser Tyr Phe Ile His Gly Leu 85 90 95 Ser Phe Met Glu Ser Ser Val Leu Leu Thr Met Ala Phe Asp Arg Tyr 100 105 110 Val Ala Ile Cys Asn Pro Leu Arg Tyr Ser Ser Ile Leu Thr Asn Ser 115 120 125 Arg Ile Phe Lys Ile Gly Leu Ala Ile Val Gly Arg Ser Phe Phe Phe 130 135 140 Ile Thr Pro Pro Ile Ile Asn Leu Lys Phe Phe His Tyr Cys His Ser 145 150 155 160 His Ile Leu Ser His Ser Phe Cys Leu His Gln Asp Leu Leu Arg Leu 165 170 175 Ala Cys Ser Asp Ile Arg Phe Asn Ser Tyr Tyr Ala Leu Met Leu Val 180 185 190 Ile Phe Thr Leu Leu Leu Asp Ala Ile Leu Ile Leu Tyr Ser Tyr Phe 195 200 205 Leu Ile Leu Arg Ser Val Leu Val Ile Ala Ser Gln Glu Glu Arg His 210 215 220

Page 3772

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Lys Ser 225 Phe Gln Thr Cys Val 230 Ser His Ile Cys Ala Val Leu Val Phe 235 240 Tyr Ile Pro Ile Ile Ser Leu Thr Met Met His Arg Phe Gly Lys His 245 250 255 Leu Ser Pro Val Val His Val Leu Met Gly Asn Ile Tyr Ile Leu Phe 260 265 270 Pro Pro Leu Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Gln Gln Ile 275 280 285 Arg Ser Arg Met Leu Arg Leu Phe Ser Leu Lys Xaa 290 295 300

<210> 3375 <211> 932 <212> DNA <213> Felis catus <400> 3375

tcaagccctt ctgtgcacag aaaataggcg aatgatactt ctctgaattt gcttggtctt 60 gatgctatat ataatggggt tcatgaatgg aggaaagaga aagtagacat agctcatagt 120 aatgtggatc acacgtgatg catgtttctc aaacctgtgg atgaaggtca ggccaatcac 180 agtaatataa aagaccagaa cacagctaat atgggagaca caggtgttaa gggccttagc 240 tcgctcttct ccagaggcga tgcccataac tgtcttcaag attaaaatac aagagaagag 300 aataatctga gcatctagga agaaagtcaa agcaaccaga ataactggat atacacgatt 360 aaatgtaata tcagcacaag cgagtttcat gacatcttgg tggaggcaaa aggcacggga 420 aagaacatgg gaacggcaat atgggaacca atagagtgac acaattgggg gcacaatgga 480 cacaaagtcc cttgtttgta ctccaagtcc tattttcatc acctgggaat tggtaagaat 540 ggagttatac ctcagagcgg tgcagatggc aatgaatcgg tcataggcca tggcaaacaa 600 gacacctgat tccacaatgg acagggtgtg aatgaagtag gactgagtga aatagtcacc 660 ctgggaaatt tccctctgga aaattggaca ctcaggactg tgggcactgt ggttagtgtc 720

Page 3773

069269_0225_SL.TXT atcccaaggt ctgtacctgc cagcatagct aggaagtagt acatgcgctc atgaagactg gagtcattcc aaatgagaaa gagaagtgtg ccattgacca aaaggatgga gaggtagatg ataaagaagg gaatagagat ccagtgctga attgcctctg agcccagaaa gccagtcagc aagaagggag cagcactgtt gttggaccac at

780

840

900

932 <210> 3376 <211> 196 <212> PRT <213> Felis catus

<400> 3376 Asp Arg 5 Phe Ile Ala Ile Cys Thr Ala Leu Arg Tyr Asn Met 1 Ala Tyr 10 15 Ser Ile Leu Thr Asn Ser Gln Val Met Lys Ile Gly Leu Gly Val Gln 20 25 30 Thr Arg Asp Phe Val Ser Ile Val Pro Pro Ile Val Ser Leu Tyr Trp 35 40 45 Phe Pro Tyr Cys Arg Ser His Val Leu Ser Arg Ala Phe Cys Leu His 50 55 60 Gln Asp Val Met Lys Leu Ala Cys Ala Asp Ile Thr Phe Asn Arg Val 65 70 75 80 Tyr Pro Val Ile Leu Val Ala Leu Thr Phe Phe Leu Asp Ala Gln Ile 85 90 95 Ile Leu Phe Ser Cys Ile Leu Ile Leu Lys Thr Val Met Gly Ile Ala 100 105 110 Ser Gly Glu Glu Arg Ala Lys Ala Leu Asn Thr Cys Val Ser His Ile 115 120 125 Ser Cys Val Leu Val Phe Tyr Ile Thr Val Ile Gly Leu Thr Phe Ile 130 135 140

His Arg Phe Glu

Lys

His Ala Ser Arg Val

Ile His

Ile Thr Met Ser

Page 3774

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145 150 155 160

Tyr Val Tyr Phe Leu Phe Pro Pro Phe Met Asn Pro Ile Ile Tyr Ser 165 170 175 Ile Lys Thr Lys Gln Ile Gln Arg Ser Ile Ile Arg Leu Phe Ser Val

180 185 190

His Arg Arg Ala 195 <210> 3377 <211> 936 <212> DNA <213> Felis catus <400> 3377

tcaagctctc ctatgcatag aaaataggca aatgatgttt ctctgaattt gcttggtctt 60 gatgctatat ataatggggt tcatgaatgg aggaaagaga aagtagacat agctcatagt 120 aatgtggatc acacgtggtg catgtttccc aaacctgtgg atgaaggtca ggccaatcac 180 agtaatataa aagaccagaa cacagctaat atgggagaca caggtgttaa gggccttagc 240 tcgctcttct ccagaggcga tgcccataac tgtcttcaag attaaaatat aagagaagag 300 aataatcaga gcatctagga agaaagtcaa agcaaccaga ataactggat atacacgatt 360 aaatgtaata tcagcacaag caagtttcat gacatcttgg tggaggcaaa aggcatggga 420 gagaacatgg gaacggcaat atgggaacca atagagtggc acgattgggg gcacaaggga 480 taaaaagccc ctcattagta cccccaggcc taccttcatc acctgggaat tggtaagaat 540 ggagttatac ctcagagggg tgcggatggc gatgaatcgg tcataggcca tggcaagcaa 600 gacaccagat tccacaatgg aaagggagtg aatgaagtag gcctgcagga agcaggctcc 660 atggctcatc tgccggtgat tcatccacaa gacacccatc acagttggca tcgtggtcaa 720 tgtcaccatc agatctgtgc ctgccagcat agcaaggaaa taatacatgg gttcatggag 780 gctgtggtca tccttgatta ggtagaggag agtaccattg ccaagaagca cagagatgta 840 gacagcaaag aaggggatgg agatccaggg atgagcagct tccagacctg ggaagccagt 900 cagcaaaaag ggggcagcac taatattggg ccacat 936

Page 3775

069269_0225_SL.TXT <210> 3378 <211> 311 <212> PRT <213> Felis catus

<400> 3378 Met 1 Trp Pro Asn Ile 5 Ser Ala Ala Pro Phe Leu Leu Thr Gly Phe Pro 10 15 Gly Leu Glu Ala Ala His Pro Trp Ile Ser Ile Pro Phe Phe Ala Val 20 25 30 Tyr Ile Ser Val Leu Leu Gly Asn Gly Thr Leu Leu Tyr Leu Ile Lys 35 40 45 Asp Asp His Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ala Met Leu 50 55 60 Ala Gly Thr Asp Leu Met Val Thr Leu Thr Thr Met Pro Thr Val Met 65 70 75 80 Gly Val Leu Trp Met Asn His Arg Gln Met Ser His Gly Ala Cys Phe 85 90 95 Leu Gln Ala Tyr Phe Ile His Ser Leu Ser Ile Val Glu Ser Gly Val 100 105 110 Leu Leu Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Arg Thr Pro Leu 115 120 125 Arg Tyr Asn Ser Ile Leu Thr Asn Ser Gln Val Met Lys Val Gly Leu 130 135 140 Gly Val Leu Met Arg Gly Phe Leu Ser Leu Val Pro Pro Ile Val Pro 145 150 155 160 Leu Tyr Trp Phe Pro Tyr Cys Arg Ser His Val Leu Ser His Ala Phe 165 170 175

Page 3776

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Cys Leu His Gln Asp 180 Val Met Lys Leu 185 Ala Cys Ala Asp Ile 190 Thr Phe Asn Arg Val Tyr Pro Val Ile Leu Val Ala Leu Thr Phe Phe Leu Asp 195 200 205 Ala Leu Ile Ile Leu Phe Ser Tyr Ile Leu Ile Leu Lys Thr Val Met 210 215 220 Gly Ile Ala Ser Gly Glu Glu Arg Ala Lys Ala Leu Asn Thr Cys Val 225 230 235 240 Ser His Ile Ser Cys Val Leu Val Phe Tyr Ile Thr Val Ile Gly Leu 245 250 255 Thr Phe Ile His Arg Phe Gly Lys His Ala Pro Arg Val Ile His Ile 260 265 270 Thr Met Ser Tyr Val Tyr Phe Leu Phe Pro Pro Phe Met Asn Pro Ile 275 280 285 Ile Tyr Ser Ile Lys Thr Lys Gln Ile Gln Arg Asn Ile Ile Cys Leu 290 295 300 Phe Ser Met His Arg Arg Ala

305 310 <210> 3379 <211> 891 <212> DNA

<213> Felis catus <400> 3379 aatttgcttg gtcttgatgc tatagatgac aggattcatt aaaggaggga agaggaagta gaaatagctc attattacgt ggaccactgg tggcacattc ttcccaaacc tgtggatgaa tgacggacca accacagtga catagaagat aagaacagag ccaatgtggg agatacaagt attgagggcc ttggttctct cttaaccaga ggctatgccc atgacagtct taagaattag gatataggaa aaaagggtaa tcagagaatc taggaagatt gttgaaagaa ccaaaattac

120

180

240

300

Page 3777

069269_0225_SL.TXT

agagtaaagt ctattggaag ttatgtcagc acaggccagt tttatgactt cttgatgaag 360 acagaaagca tgggagagaa catgagagtg gcaatatgga aatgagaaaa agctgcagga 420 ttacagggac gatggatatg aaacccctca taaaagttcc catccctaaa gttacaacac 480 gagtattggt gagaatggaa gtgtatttca agggattgtg gaaggcaata aaatggtcat 540 aggccatagc aagtaagata cctgattcca tgatggaaag ggagtgaatg aagtaggcct 600 gcaggaagca ggctccatgg ctcatcttcc ggtgattcat ccacaagaca cccatcacag 660 ttggcatcgt gatcaatgtc accatcagct ctgtgcctgc cagcatggca aggaaataat 720 acatgggttc atagaggctg tggtcatcct tgatgaggca gaggagagtg tcattgccaa 780 gaagcacaga gatgtagaca gcaaagaagg ggatggagat ccagtgatga gcagcttcca 840 gacctgggga gccagtcagc aaaaggggcc agcactaata ttgggccaca t 891

<210> 3380 <211> 92 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (92)..(92) <223> Any amino acid <400> 3380

Met Ala His Leu Pro Val Ile His Pro Gln Asp Thr His His Ser Trp 1 5 10 15

His Arg Asp Gln Cys His His Gln Leu Cys Ala Cys Gln His Gly Lys 20 25 30

Glu Ile Ile His Gly Phe Ile Glu Ala Val Val Ile Leu Asp Glu Ala 35 40 45

Glu Glu Ser Val Ile Ala Lys Lys His Arg Asp Val Asp Ser Lys Glu 50 55 60

Gly Asp Gly Asp Pro Val Met Ser Ser Phe Gln Thr Trp Gly Ala Ser 65 70 75 80

Page 3778

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Gln Gln Lys Gly Pro Ala Leu Ile Leu Gly His Xaa 85 90 <210> 3381 <211> 932 <212> DNA <213> Felis catus <400> 3381

tcaaattcta tgcaaagaga gaaggtgatt gatgccattc cttatctgct tggtcttaat 60 actatagatg attggattca taaatggggg gaagaggaag taaatatagc tcatgataat 120 atgaactaca tgtggcacat atttcccaaa tcgatgaata agggtcaacc cagtaacagt 180 gacataaaaa ccagaacaca gctaatatgg gagacacaag tgtttagagc cttagcctgc 240 tccttacctg aggcaatccc catgacagta ttaaggatta gaatataaga gatcaggata 300 agcacagagt ccaagaagcc agttaatgag actagcacta taggatagag tctattgaag 360 gtgatgtcag cacaggccag tttgatcaca tcctggtgta ggcagaaagc atgagagaga 420 acatgggatc cacagtaggg aaatccagag agggtgatga ttatgggcac aataagtata 480 aatcccctca ttagaacccc cagacctatc ttcaccaccc tagcattggt gaggatggag 540 gtgtatctca ggggactgtg gatggcaatg aaacgatcat aggccataac aagcaagact 600 ccagactcca caatagagag tgaatggatt agataggcct gaaagtagca ggctccttgg 660 ctgattgccc tgtgaccaag ccacagaaca ccaagcacgg tgggcattgt tgtcaaagtc 720 actccaaggt ctgtggctgc caacagagcc acaaagtagt acatcggctg gtggagagtg 780 tggtcttctc tgataaggta gaggatggtg ccattgccaa ggagtatgga gacataaatg 840 acaaagaaag agacggaaat ccaaggatga aatatcccca gacctggaaa gccagtcagt 900 agaaaagggg cagcactgat gttggaccac at 932

<210> 3382 <211> 255 <212> PRT <213> Felis catus <400> 3382

Met Trp Ser Asn Ile Ser Ala Ala Pro Phe Leu Leu Thr Gly Phe Pro 1 5 10 15

Page 3779

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Gly Leu Gly Ile 20 Phe His Pro Trp Ile Ser Val Ser Phe Phe Val Ile 25 30 Tyr Val Ser Ile Leu Leu Gly Asn Gly Thr Ile Leu Tyr Leu Ile Arg 35 40 45 Glu Asp His Thr Leu His Gln Pro Met Tyr Tyr Phe Val Ala Leu Leu 50 55 60 Ala Ala Thr Asp Leu Gly Val Thr Leu Thr Thr Met Pro Thr Val Leu 65 70 75 80 Gly Val Leu Trp Leu Gly His Arg Ala Ile Ser Gln Gly Ala Cys Tyr 85 90 95 Phe Gln Ala Tyr Leu Ile His Ser Leu Ser Ile Val Glu Ser Gly Val 100 105 110 Leu Leu Val Met Ala Tyr Asp Arg Phe Ile Ala Ile His Ser Pro Leu 115 120 125 Arg Tyr Thr Ser Ile Leu Thr Asn Ala Arg Val Val Lys Ile Gly Leu 130 135 140 Gly Val Leu Met Arg Gly Phe Ile Leu Ile Val Pro Ile Ile Ile Thr 145 150 155 160 Leu Ser Gly Phe Pro Tyr Cys Gly Ser His Val Leu Ser His Ala Phe 165 170 175 Cys Leu His Gln Asp Val Ile Lys Leu Ala Cys Ala Asp Ile Thr Phe 180 185 190 Asn Arg Leu Tyr Pro Ile Val Leu Val Ser Leu Thr Gly Phe Leu Asp 195 200 205 Ser Val Leu Ile Leu Ile Ser Tyr Ile Leu Ile Leu Asn Thr Val Met 210 215 220

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Gly Ile Ala Ser Gly Lys Glu Gln Ala Lys Ala Leu Asn Thr Cys Val 225 230 235 240

Ser His Ile Ser Cys Val Leu Val Phe Met Ser Leu Leu Leu Gly 245 250 255 <210> 3383 <211> 920 <212> DNA <213> Felis catus <400> 3383

atggttagta aaaaggtgaa gaaagccact ccggatctgc ttggtcttga cactatagat 60 cataggattc attagtggag ggaaaagaaa atatacatag ctcatagtga ggtggacaat 120 atgtggaacc tgcttcccaa accgatgaat cagagacaat ccaatgactg tgacatagaa 180 aaccaggaca cagcagatat gggagacaca ggtgttgaag gccttggccc tctcttcttt 240 ggaggcaatt ctcaggacac tcttgagtat caatacatag gagatgagga tgatcagaga 300 atccagcaca aatataaaga ctacaagcac aactggatac agtcgattga aggtggtgtc 360 agcacaggcc agtttgatga catcctggtg aaggcagaat gcatgagaga ggacatggga 420 atggcaatag ggaaaaaaat aaaggggtac aattggaggg ataacagata caaaccccct 480 cagcagaact cccagtccaa ttttcagcac ttgagtataa gtgagtatgg aggtatatct 540 aagggggttg cgaatggcaa taaaacgatc ataagccata gcaagcaaaa caccagactc 600 tacaaaggca agtgagtgta taaagtaggc ttgagaaaaa caggctactt tcccaatctc 660 cctgtgaccc aaccagagga ctctgagcac cgtaggcatc gtggtcaagg tcagccctaa 720 gtctgtggct gctagcatgg ccaggaaata gtacataggt tcatgaagat tgggatcttc 780 cttaatgaga aggaggaggg tgctgttgcc taaaaggaca gagatgtaga tgaaaaagaa 840 gggtgtggaa atccagtggt gagctgcctc caagcctggg aaaccagtca acaggaagga 900 actggaattg ccgttcggcc 920

<210> 3384 <211> 306 <212> PRT

Page 3781

069269_0225_SL.TXT <213> Felis catus <400> 3384

Pro Asn Gly Asn Ser Ser Ser Phe Leu Leu Thr Gly Phe Pro Gly Leu 1 5 10 15 Glu Ala Ala His His Trp Ile Ser Thr Pro Phe Phe Phe Ile Tyr Ile 20 25 30 Ser Val Leu Leu Gly Asn Ser Thr Leu Leu Leu Leu Ile Lys Glu Asp 35 40 45 Pro Asn Leu His Glu Pro Met Tyr Tyr Phe Leu Ala Met Leu Ala Ala 50 55 60 Thr Asp Leu Gly Leu Thr Leu Thr Thr Met Pro Thr Val Leu Arg Val 65 70 75 80 Leu Trp Leu Gly His Arg Glu Ile Gly Lys Val Ala Cys Phe Ser Gln 85 90 95 Ala Tyr Phe Ile His Ser Leu Ala Phe Val Glu Ser Gly Val Leu Leu 100 105 110 Ala Met Ala Tyr Asp Arg Phe Ile Ala Ile Arg Asn Pro Leu Arg Tyr 115 120 125 Thr Ser Ile Leu Thr Tyr Thr Gln Val Leu Lys Ile Gly Leu Gly Val 130 135 140 Leu Leu Arg Gly Phe Val Ser Val Ile Pro Pro Ile Val Pro Leu Tyr 145 150 155 160 Phe Phe Pro Tyr Cys His Ser His Val Leu Ser His Ala Phe Cys Leu 165 170 175 His Gln Asp Val Ile Lys Leu Ala Cys Ala Asp Thr Thr Phe Asn Arg 180 185 190 Leu Tyr Pro Val Val Leu Val Val Phe Ile Phe Val Leu Asp Ser Leu

Page 3782

195 069269_0225_SL.TXT 200 205 Ile Ile Leu Ile Ser Tyr Val Leu Ile Leu Lys Ser Val Leu Arg Ile 210 215 220 Ala Ser Lys Glu Glu Arg Ala Lys Ala Phe Asn Thr Cys Val Ser His 225 230 235 240 Ile Cys Cys Val Leu Val Phe Tyr Val Thr Val Ile Gly Leu Ser Leu 245 250 255 Ile His Arg Phe Gly Lys Gln Val Pro His Ile Val His Leu Thr Met 260 265 270 Ser Tyr Val Tyr Phe Leu Phe Pro Pro Leu Met Asn Pro Met Ile Tyr 275 280 285 Ser Val Lys Thr Lys Gln Ile Arg Ser Gly Phe Leu His Leu Phe Thr 290 295 300

Asn His 305

<210> 3385 <211> 939 <212> DNA <213> Felis catus <400> 3385 atgtggctca acaccaccac ttccctgttt ctgcttactg gtttcccagg catggagaag 60 gcacaccact ggatttccat cccattatta ggggtttacg tctccatact tcttggtaat 120 ggcactcttc tctttcttat cagggatgat cataaccttc acgagcccat gtactatttc 180 ttagctatgc tggcagccac agaccttgga gtgactttga ccacgatgcc cacagttctg 240 ggcgttctat ggttgaatca cagagagatt ggccatcagg cctgcttctc tcaggcctac 300 tttatccaca ctctttctat cgtagaatct ggtgttttgc ttgccatggc ctatgaccgc 360 ttcattgcca tccgcaaccc cttgagatat acttccatcc ttaccaacac caaggtaatg 420 aagattggga tgggggtatt gacaagggct ggtctgtcaa tcatgccaat aattatccgc 480

Page 3783

069269_0225_SL.TXT

ctccactggt ttccctattg tcgatcccat gtactctctc atgctttctg tctacaccaa 540 gatgtcatca agttagcttg tgctgacatc accttcaatc gtctctatcc agttgtggtt 600 gtatttgcaa tggtcttgtt ggactttctt atcatctttt tctcctactt tttgatcctt 660 aagactgtca tgggcattgc ttctggagaa gaaagggcca aggccctcaa tacgtgcatt 720 tctcacatct gctgcatcct ggtcttctat gtcactgtag ttggtctaac atttattcat 780 aggtttggaa agcatgctcc tcgtgtggtc cacatcacaa tgagctacat ctacttcctt 840 ttcccccctt ttatgaaccc tgttatatat agcattaaaa ccaagcagat ccagagtggt 900 ataattcgtt tattctctct gcctaactct agagcataa 939

<210> 3386 <211> 312 <212> PRT <213> Felis catus <400> 3386

Met Trp Leu Asn Thr Thr Thr Ser Leu Phe Leu Leu Thr Gly Phe Pro 1 5 10 15 Gly Met Glu Lys Ala His His Trp Ile Ser Ile Pro Leu Leu Gly Val 20 25 30 Tyr Val Ser Ile Leu Leu Gly Asn Gly Thr Leu Leu Phe Leu Ile Arg 35 40 45 Asp Asp His Asn Leu His Glu Pro Met Tyr Tyr Phe Leu Ala Met Leu 50 55 60 Ala Ala Thr Asp Leu Gly Val Thr Leu Thr Thr Met Pro Thr Val Leu 65 70 75 80 Gly Val Leu Trp Leu Asn His Arg Glu Ile Gly His Gln Ala Cys Phe 85 90 95 Ser Gln Ala Tyr Phe Ile His Thr Leu Ser Ile Val Glu Ser Gly Val 100 105 110

Page 3784

Leu Leu Ala 115 Met Ala Tyr Asp 069269_0225_SL.TXT Arg Phe Ile Ala Ile Arg 120 125 Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr Asn Thr Lys Val Met Lys Ile Gly Met 130 135 140 Gly Val Leu Thr Arg Ala Gly Leu Ser Ile Met Pro Ile Ile Ile Arg 145 150 155 160 Leu His Trp Phe Pro Tyr Cys Arg Ser His Val Leu Ser His Ala Phe 165 170 175 Cys Leu His Gln Asp Val Ile Lys Leu Ala Cys Ala Asp Ile Thr Phe 180 185 190 Asn Arg Leu Tyr Pro Val Val Val Val Phe Ala Met Val Leu Leu Asp 195 200 205 Phe Leu Ile Ile Phe Phe Ser Tyr Phe Leu Ile Leu Lys Thr Val Met 210 215 220 Gly Ile Ala Ser Gly Glu Glu Arg Ala Lys Ala Leu Asn Thr Cys Ile 225 230 235 240 Ser His Ile Cys Cys Ile Leu Val Phe Tyr Val Thr Val Val Gly Leu 245 250 255 Thr Phe Ile His Arg Phe Gly Lys His Ala Pro Arg Val Val His Ile 260 265 270 Thr Met Ser Tyr Ile Tyr Phe Leu Phe Pro Pro Phe Met Asn Pro Val 275 280 285 Ile Tyr Ser Ile Lys Thr Lys Gln Ile Gln Ser Gly Ile Ile Arg Leu 290 295 300 Phe Ser Leu Pro Asn Ser Arg Ala 305 310

Page 3785

069269_0225_SL.TXT <210> 3387 <211> 916 <212> DNA <213> Felis catus <400> 3387

aatgcccatt atggagctca acaccagtgc cccacccttt ctgctgaccg gcttcgtggg 60 cctggaaaag gctcaccact ggatctctat cccgttatct gtcatctaga ttgccatact 120 tcatggcaat ggcattctcc tatttctcat cagggttgac cataacctcc acgagcccat 180 gtactatttc ttagccatgc tggcaaccac agacctcggg atgaccctgg ttacaatgcc 240 tacagtgctg tgtgtgatgt ggacaaatca tagggaaatc agccatggct cctgcttttg 300 ccaagcctgc ttcatccaca ctttctctgt catacagtct gggattttgc ttgccaaggc 360 ctatgatcag tttgttgcca tccacaaccc actgagatat acttccattc ttaccaacac 420 ccaaatgata aagattggag tgggggtttt catgaaggga tttacagtca tcttgcctcc 480 aatattccct ctcgattggt tttcctattg caggtcccat ttcttctctc atgcattctg 540 cctccaccag gatgtcatca aattagcctg tgctgacatc accttcaatt gcctatatcc 600 tattgtgatg gtattttcta tggtcctaat ggactgcctg ataatctttt cttctatatt 660 ttgattctca aaactgtcat gagtattgca tctggagagg aggggtccaa ggcactcaac 720 aaatgtgcct cccacatctg ctgtatcttg gtcttctatg tcactgtttt ggtttgacat 780 tcatctaccg atttgggaag aaatggtccc catctagtac acatcacaaa tagctacatc 840 tacttccttt cccttctttt atgaaccctg tcatctgtag tattaaaact aagcagattc 900 acagtagtat tctcca 916

<210> 3388 <211> 52 <212> PRT <213> Felis catus <400> 3388

Asn Ala His Tyr Gly Ala Gln His Gln Cys Pro Thr Leu Ser Ala Asp 1 5 10 15

Arg Leu Arg Gly Pro Gly Lys Gly Ser Pro Leu Asp Leu Tyr Pro Val 20 25 30

Page 3786

069269_0225_SL.TXT

Ile Cys His Leu Asp Cys His Thr Ser Trp Gln Trp His Ser Pro Ile 35 40 45

Ser His Gln Gly 50 <210> 3389 <211> 812 <212> DNA <213> Felis catus <400> 3389 acaattggag gggcatgctt ggcaaagcgg tgagtcatgg aaagtcccac caagggcaca 60 tagaggacca gaacagccag aatgtgggac agacagttat tgagagcctg gaaactttca 120 ccctgggagc tgattctcaa gacacttctc agaatgagtg cataggagac cacaatgagc 180 agggggtcca atgtagtaaa gaccagagct ataacaaatc cataccaatt attgatagtg 240 gtatcagcac acaccaggcg aatcatgtct tgatgaaggc agtaggagtg ggagagatgg 300 tgggagccac aaaatggaag ccgtttcagt aggaataatg caggaagaac agtcagaaca 360 cagcggaaaa tgatggctat ccctattctt ctgatgaccc ggttggtaag gatggagaca 420 taatggaggg ggcggcagat ggccacatag cggtcaaagg acatggccaa caacacggaa 480 gattccataa aagagaatcc atggaggaag aagaactggg caaaacaagc ctcaaagctg 540 atctctgagg cattaaacca gaggagtccc atgactgtag gcaaagtggt gagggtaagc 600 cccaggtctg ttagagccaa aatagagagg aacaagtaca tgggctcttg tagggagggc 660 tctatcctga tgacagccag gatggtgata ttgcccacaa tggagaccgt gtagagacaa 720 cagaagggga tggaaatcca gccatgggaa acctcaaagc cagggatgcc catgaggatg 780 aagaagaagg ggacttgagt ggagttagta ac 812 <210> 3390 <211> 271 <212> PRT <213> Felis catus <400> 3390

Val Thr Asn Ser Thr Gln Val Pro Phe Phe Phe Ile Leu Met Gly Ile 1 5 10 15

Page 3787

069269_0225_SL.TXT

Pro Gly Phe Glu 20 Val Ser His Gly Trp Ile Ser Ile Pro Phe Cys Cys 25 30 Leu Tyr Thr Val Ser Ile Val Gly Asn Ile Thr Ile Leu Ala Val Ile 35 40 45 Arg Ile Glu Pro Ser Leu Gln Glu Pro Met Tyr Leu Phe Leu Ser Ile 50 55 60 Leu Ala Leu Thr Asp Leu Gly Leu Thr Leu Thr Thr Leu Pro Thr Val 65 70 75 80 Met Gly Leu Leu Trp Phe Asn Ala Ser Glu Ile Ser Phe Glu Ala Cys 85 90 95 Phe Ala Gln Phe Phe Phe Leu His Gly Phe Ser Phe Met Glu Ser Ser 100 105 110 Val Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Arg Pro 115 120 125 Leu His Tyr Val Ser Ile Leu Thr Asn Arg Val Ile Arg Arg Ile Gly 130 135 140 Ile Ala Ile Ile Phe Arg Cys Val Leu Thr Val Leu Pro Ala Leu Phe 145 150 155 160 Leu Leu Lys Arg Leu Pro Phe Cys Gly Ser His His Leu Ser His Ser 165 170 175 Tyr Cys Leu His Gln Asp Met Ile Arg Leu Val Cys Ala Asp Thr Thr 180 185 190 Ile Asn Asn Trp Tyr Gly Phe Val Ile Ala Leu Val Phe Thr Thr Leu 195 200 205 Asp Pro Leu Leu Ile Val Val Ser Tyr Ala Leu Ile Leu Arg Ser Val 210 215 220

Page 3788

069269_0225_SL.TXT

Leu 225 Arg Ile Ser Ser Gln Gly Glu Ser Phe Gln Ala Leu Asn Asn Cys 230 235 240 Leu Ser His Ile Leu Ala Val Leu Val Leu Tyr Val Pro Leu Val Gly 245 250 255 Leu Ser Met Thr His Arg Phe Ala Lys His Ala Pro Pro Ile Val 260 265 270

<210> 3391 <211> 960 <212> DNA <213> Felis catus <400> 3391

atgctcttat ccaacattac tcagtttagt cccatgttct acctcactgg ctttcctgga 60 ttggacacca tcgaacactg gattttcatc ccctttttcc ttatgtacct tgtggccatc 120 tcgggcaatt gtttcattct gatagttatt aagaccaacc ctcgtctgca cagacccatg 180 tactatctac tctcttttct ggccttcact gacctgggac tgtcagtgtc taccttgccc 240 accactatgg gaatcttttg gttcaaatct catggtatct actttgtggc ttgtcagatc 300 cagatgttct gtatccactc attttccttc atggagtcct cagtgctcct tattatgtcc 360 tttgaccgct ttttggctat ctgccacccc cttaggtact cggtcattat cactagccag 420 cgagtgatca gggcaggtct ggctgtcatc ttccggggac ctgtggccct agttcccctt 480 gtcctcctcc tgaagacttt tccctactgt gggcctcgag tcctttccca ttctttctgc 540 ctacaccagg aagtgataca cttggcctgc acagatacca ccttcaacaa cctgtatggg 600 ctggcagtgg tggtgttcac tatgatgttg gacctggtgc tcattgcact gtcttatggg 660 gtcatcctgc acaccgtggc aagactggcc tcccaagagg agcagctccg agccttccaa 720 acatgtacct cacacctctg tgctgtactg atattctttg tgcctatggt ggggctgtcc 780 ctcgtgcacc gctttgggaa gcacgtccca cttgctgtcc accttctcat ggccaatgtc 840 tatctctttg tgcctcctat gcttaatcca atcatataca gtattaagac caaggagatc 900 cgccacatca tcagcaaact cctcggtctt aagaacgtca gtactaagtc ttggagctaa 960

Page 3789

069269_0225_SL.TXT <210> 3392 <211> 319 <212> PRT <213> Felis catus

<400> 3392 Ile Thr Gln Phe Ser Pro Met Phe Tyr Leu Thr Met 1 Leu Leu Ser Asn 5 10 15 Gly Phe Pro Gly Leu Asp Thr Ile Glu His Trp Ile Phe Ile Pro Phe 20 25 30 Phe Leu Met Tyr Leu Val Ala Ile Ser Gly Asn Cys Phe Ile Leu Ile 35 40 45 Val Ile Lys Thr Asn Pro Arg Leu His Arg Pro Met Tyr Tyr Leu Leu 50 55 60 Ser Phe Leu Ala Phe Thr Asp Leu Gly Leu Ser Val Ser Thr Leu Pro 65 70 75 80 Thr Thr Met Gly Ile Phe Trp Phe Lys Ser His Gly Ile Tyr Phe Val 85 90 95 Ala Cys Gln Ile Gln Met Phe Cys Ile His Ser Phe Ser Phe Met Glu 100 105 110 Ser Ser Val Leu Leu Ile Met Ser Phe Asp Arg Phe Leu Ala Ile Cys 115 120 125 His Pro Leu Arg Tyr Ser Val Ile Ile Thr Ser Gln Arg Val Ile Arg 130 135 140 Ala Gly Leu Ala Val Ile Phe Arg Gly Pro Val Ala Leu Val Pro Leu 145 150 155 160 Val Leu Leu Leu Lys Thr Phe Pro Tyr Cys Gly Pro Arg Val Leu Ser 165 170 175 His Ser Phe Cys Leu His Gln Glu Val Ile His Leu Ala Cys Thr Asp

Page 3790

180

069269_0225_SL.TXT 185 190

Thr Thr Phe Asn Asn Leu Tyr Gly Leu Ala Val Val Val Phe Thr Met 195 200 205 Met Leu Asp Leu Val Leu Ile Ala Leu Ser Tyr Gly Val Ile Leu His 210 215 220 Thr Val Ala Arg Leu Ala Ser Gln Glu Glu Gln Leu Arg Ala Phe Gln 225 230 235 240 Thr Cys Thr Ser His Leu Cys Ala Val Leu Ile Phe Phe Val Pro Met 245 250 255 Val Gly Leu Ser Leu Val His Arg Phe Gly Lys His Val Pro Leu Ala 260 265 270 Val His Leu Leu Met Ala Asn Val Tyr Leu Phe Val Pro Pro Met Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Ile Lys Thr Lys Glu Ile Arg His Ile Ile 290 295 300 Ser Lys Leu Leu Gly Leu Lys Asn Val Ser Thr Lys Ser Trp Ser

305 310 315 <210> 3393 <211> 953 <212> DNA <213> Felis catus <400> 3393

atgaagaact ctaatagctc tttggagttc ttacctacaa cgttcattct gattggcatc 60 ccaggactgg aggcagagca cctctggata tccatcccct tctgcctgat gtacactatc 120 atcttccttg ggaatggcac catccttcat gtcatcagaa cagacactgc cctacaccag 180 cccatgtacc tccttcttgc catgttggca ctcgctgagg ttggtgtctc tgcatctact 240 ctgcctacgg tgctaggcat cttccttttt ggcatcactg agattagttt tgatgtatgc 300 ctttttcaga tgtttttcat ccattcattc tccattatgg agtcagctgt gttgctggcc 360

Page 3791

069269_0225_SL.TXT

atgtctgtgg accgatttgt ggccatctat agcccactgc gctatacagc cattctaacc 420 ctgccccgta tctttggcac aggagctgtc atggggctga aaagcattat gctcatggcc 480 ccattgccca tgctgttaag gcgcctgccc ttctgtggcc acaacgtcct ctcccattcc 540 tattgcctcc accccaacct tatccatcta ccttgcgggg acatttctat caacaatatc 600 tatgggcttt tcattgttac ctccactttt gggctggatt cactgcttat tgtcatctcc 660 tatgggctca tactccacac tgtaatgagt atcaccactg gggaggggcg gaggaaggca 720 ctcaacacat gtggctcaca tatctgtgct gtgctcgctt actatgtgcc tatgattggc 780 ttatctatgg tgcaccgctt tggacaccac gtgtcccctt tgctgcatgc tatgatagcc 840 aatgcttatc tcttcttccc acctgttgtc aaccccattg tctacagcat taagaccaag 900 gagatccatc gtggcattgt ccgaatgttc tcagagaaaa gagccagagt tta 953

<210> 3394 <211> 318 <212> PRT <213> Felis catus <220>

<221> MOD_RES

<222> (318) ..(318) <223> Any amino acid <400> 3394 Met Lys Asn Ser Asn Ser Ser Leu Glu Phe Leu Pro Thr Thr Phe Ile 1 5 10 15 Leu Ile Gly Ile Pro Gly Leu Glu Ala Glu His Leu Trp Ile Ser Ile 20 25 30 Pro Phe Cys Leu Met Tyr Thr Ile Ile Phe Leu Gly Asn Gly Thr Ile 35 40 45 Leu His Val Ile Arg Thr Asp Thr Ala Leu His Gln Pro Met Tyr Leu 50 55 60 Leu Leu Ala Met Leu Ala Leu Ala Glu Val Gly Val Ser Ala Ser Thr 65 70 75 80

Page 3792

069269_0225_SL.TXT

Leu Pro Thr Val Leu 85 Gly Ile Phe Leu Phe Gly Ile Thr Glu Ile Ser 90 95 Phe Asp Val Cys Leu Phe Gln Met Phe Phe Ile His Ser Phe Ser Ile 100 105 110 Met Glu Ser Ala Val Leu Leu Ala Met Ser Val Asp Arg Phe Val Ala 115 120 125 Ile Tyr Ser Pro Leu Arg Tyr Thr Ala Ile Leu Thr Leu Pro Arg Ile 130 135 140 Phe Gly Thr Gly Ala Val Met Gly Leu Lys Ser Ile Met Leu Met Ala 145 150 155 160 Pro Leu Pro Met Leu Leu Arg Arg Leu Pro Phe Cys Gly His Asn Val 165 170 175 Leu Ser His Ser Tyr Cys Leu His Pro Asn Leu Ile His Leu Pro Cys 180 185 190 Gly Asp Ile Ser Ile Asn Asn Ile Tyr Gly Leu Phe Ile Val Thr Ser 195 200 205 Thr Phe Gly Leu Asp Ser Leu Leu Ile Val Ile Ser Tyr Gly Leu Ile 210 215 220 Leu His Thr Val Met Ser Ile Thr Thr Gly Glu Gly Arg Arg Lys Ala 225 230 235 240 Leu Asn Thr Cys Gly Ser His Ile Cys Ala Val Leu Ala Tyr Tyr Val 245 250 255 Pro Met Ile Gly Leu Ser Met Val His Arg Phe Gly His His Val Ser 260 265 270 Pro Leu Leu His Ala Met Ile Ala Asn Ala Tyr Leu Phe Phe Pro Pro 275 280 285

Page 3793

069269_0225_SL.TXT

Val Val Asn Pro Ile Val Tyr Ser Ile Lys Thr Lys Glu Ile His Arg 290 295 300 Gly Ile Val Arg Met Phe Ser Glu Lys Arg Ala Arg Val Xaa

305 310 315 <210> 3395 <211> 949 <212> DNA <213> Felis catus <400> 3395

atgtccaagg tgacgaacag cacccaagca cccttctact tcatcctcac cggcatccct 60 ggatttgagg cctcccacat ctggatctcc attcccttct gctgcctcta caccatctcc 120 atcatgggta acaccaccat tctcacggtc atccgcaagg aaccatccct ccaccagccc 180 atgtacctat ttctctccat gctggccctg accgacctgg gcctcaccct caccaccctg 240 cccacagtca tgcagctcct ctggttcaac attcatgaga tcagctttga agcgtgtttt 300 gcacagttat ttttcattca tacattctcc tttatggaat cttctgtgtt gttggccatg 360 tcctttgatc gctatgtggc catctgccgc cccctgcatt atacctccat cctcaccggt 420 gaagtcattg gcaagatcgg cttagccatc atttgccgct gtgtcctggc tgttctccct 480 tccctcttcc tactcaagcg cctgcccttc tgccgctccc accttctctc tcactcctat 540 tgcctccacc aggatatgat ccgcctcgtc tgtgctgaca tccgggtcaa tagctggtat 600 ggatttgctc ttgttttgct cattattgtg atggaccctt tgctcattgt gctctcctac 660 acactcatcc tgaagagtat cttgggcaca gcctcctgga ctgagcggtt ccgggccctc 720 aaaaactgtc tatcccatgt gctggctgtt ctggtccttt atgttcccat ggttggagta 780 tccatgactc atcgatttgc caagcatgcc tctccgctgg tccatgttat catggccaat 840 atctacctgt tggcaccgcc tgtgatgaac cccatcattt acagtgtcaa gactaagcag 900 atccgtcagg gaattatctg cctcctttcc caaagagata tgtgcttaa 949

<210> 3396 <211> 317 <212> PRT

Page 3794

069269_0225_SL.TXT <213> Felis catus <220>

<221> MOD_RES <222> (317)..(317) <223> Any amino acid

<400> 3396 Met 1 Ser Lys Val Thr 5 Asn Ser Thr Gln Ala Pro Phe Tyr Phe Ile Leu 10 15 Thr Gly Ile Pro Gly Phe Glu Ala Ser His Ile Trp Ile Ser Ile Pro 20 25 30 Phe Cys Cys Leu Tyr Thr Ile Ser Ile Met Gly Asn Thr Thr Ile Leu 35 40 45 Thr Val Ile Arg Lys Glu Pro Ser Leu His Gln Pro Met Tyr Leu Phe 50 55 60 Leu Ser Met Leu Ala Leu Thr Asp Leu Gly Leu Thr Leu Thr Thr Leu 65 70 75 80 Pro Thr Val Met Gln Leu Leu Trp Phe Asn Ile His Glu Ile Ser Phe 85 90 95 Glu Ala Cys Phe Ala Gln Leu Phe Phe Ile His Thr Phe Ser Phe Met 100 105 110 Glu Ser Ser Val Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Arg Pro Leu His Tyr Thr Ser Ile Leu Thr Gly Glu Val Ile Gly 130 135 140 Lys Ile Gly Leu Ala Ile Ile Cys Arg Cys Val Leu Ala Val Leu Pro 145 150 155 160 Ser Leu Phe Leu Leu Lys Arg Leu Pro Phe Cys Arg Ser His Leu Leu 165 170 175

Page 3795

069269_0225_SL.TXT

Ser His Ser Tyr 180 Cys Asp Ile Arg 195 Val Asn Ile Val 210 Met Asp Pro Lys 225 Ser Ile Leu Gly Lys Asn Cys Leu Ser 245 Met Val Gly Val 260 Ser Leu Val His 275 Val Ile Met Asn 290 Pro Ile Ile Ile Ile Cys Leu Leu

305

Leu His Gln Asp 185 Met Ile Ser Trp Tyr 200 Gly Phe Ala Leu Leu 215 Ile Val Leu Ser Thr 230 Ala Ser Trp Thr Glu 235 His Val Leu Ala Val 250 Leu Met Thr His Arg 265 Phe Ala Met Ala Asn 280 Ile Tyr Leu Tyr Ser 295 Val Lys Thr Lys Ser 310 Gln Arg Asp Met Cys 315

Arg Leu Val 190 Cys Ala Leu Val 205 Leu Leu Ile Tyr 220 Thr Leu Ile Leu Arg Phe Arg Ala Leu 240 Val Leu Tyr Val 255 Pro Lys His Ala 270 Ser Pro Leu Ala 285 Pro Pro Val Gln 300 Ile Arg Gln Gly Leu Xaa

<210> 3397 <211> 940 <212> DNA <213> Felis catus <400> 3397 atttcctctt gcaggagaac tgtagatgat ggggttgagc ggaccagggg tgaggcatgc cgtagtacat gagcactgcg cctccccaga agcaatgccc aaggtgaaaa tcccctgtcg acaggaggca caaagaggta ttggcagcac gatgcatcac cagatatgtg acacacacgt agcactgtgt aaagaatcag

Page 3796 gattggcttg gtcttgacac gacgctagac atgagtgtgt agacacacca atcatgggca gttgagggcc ttccgccgtc cacataagag acaatgataa

120

180

240

300

069269_0225_SL.TXT

gcagtgagtc cagcccaaaa gtggccagga cgatggccaa acccaggatg ctactgagct 360 tcgtatcacc acaaggcagc tggatcaggt ctgagtggag gcagtaggaa tgggagagta 420 cattggtgtg acaatagggc agttgtttca aaaggactgg aagtggggcc atgagcatca 480 cactcttcag tgtgatgccc agacccatgc aaatgatacg tggcagggtt aggatggctg 540 tatatcgcag tggactgtag atggctacaa agcggtcata actcatggcc aacaggaccc 600 ctgattccat gcaggagaaa gtgtggatga agaacatctg agccaggcag ccatccaggt 660 caatccggcg ggcatcaaac caaagaatac ccatgacagt gggcagtgta gacacagaaa 720 cacccacctc tgtcacagcc aacatggaga gaaacaagta catgggctcg tgaagggcag 780 ggtctgcctg cactgctgcc atgattaggt tgttacccac aatggccaca atatacacag 840 tgaagaaagg aatggaaagc cagccatgtt gggcctccaa tcctgggatg ccagtcagga 900 agacggatag gtcaagactt ccattgcttt cagctcccat 940

<210> 3398 <211> 314 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (314)..(314) <223> Any amino acid

<400> 3398 Asn Gly Ser Leu Asp Leu Ser Val Phe Leu Thr Met 1 Gly Ala Glu Ser 5 10 15 Gly Ile Pro Gly Leu Glu Ala Gln His Gly Trp Leu Ser Ile Pro Phe 20 25 30 Phe Thr Val Tyr Ile Val Ala Ile Val Gly Asn Asn Leu Ile Met Ala 35 40 45 Ala Val Gln Ala Asp Pro Ala Leu His Glu Pro Met Tyr Leu Phe Leu 50 55 60

Page 3797

Ser 65 Met Leu Ala Val Thr 70 Glu 069269_0225_SL.TXT Val Gly Val Ser Val Ser 75 Thr Leu Pro 80 Thr Val Met Gly Ile Leu Trp Phe Asp Ala Arg Arg Ile Asp Leu Asp 85 90 95 Gly Cys Leu Ala Gln Met Phe Phe Ile His Thr Phe Ser Cys Met Glu 100 105 110 Ser Gly Val Leu Leu Ala Met Ser Tyr Asp Arg Phe Val Ala Ile Tyr 115 120 125 Ser Pro Leu Arg Tyr Thr Ala Ile Leu Thr Leu Pro Arg Ile Ile Cys 130 135 140 Met Gly Leu Gly Ile Thr Leu Lys Ser Val Met Leu Met Ala Pro Leu 145 150 155 160 Pro Val Leu Leu Lys Gln Leu Pro Tyr Cys His Thr Asn Val Leu Ser 165 170 175 His Ser Tyr Cys Leu His Ser Asp Leu Ile Gln Leu Pro Cys Gly Asp 180 185 190 Thr Lys Leu Ser Ser Ile Leu Gly Leu Ala Ile Val Leu Ala Thr Phe 195 200 205 Gly Leu Asp Ser Leu Leu Ile Ile Val Ser Tyr Val Leu Ile Leu Tyr 210 215 220 Thr Val Leu Gly Ile Ala Ser Gly Glu Gly Arg Arg Lys Ala Leu Asn 225 230 235 240 Thr Cys Val Ser His Ile Cys Ala Val Leu Met Tyr Tyr Val Pro Met 245 250 255 Ile Gly Val Ser Val Met His Arg Ala Ala Lys His Ala Ser Pro Leu 260 265 270

Page 3798

0 6926 9_02 25_S L.TX T Val His Thr Leu Met Ser Ser Val Tyr Leu Phe Val Pro Pro Val Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Pro Ile Arg Gln Gly Ile 290 295 300 Phe Thr Leu Phe Ser Cys Lys Arg Lys Xaa 305 310

<210> 3399 <211> 945 <212> DNA <213> Felis catus <400> 3399 tcagctctgg gatttataga ggactttgag gatccctctg cgtatctcct ttgtcttcac 60 actgtagatg atggggttga gcatgggggg tacaaacagg tagacattgg acatcatgac 120 atgaacaaca ggtggggcac tcttccagaa gcggtggatc atggagacag taattatggg 180 cacataaaaa gccagcactg cacagatgtg tgacatgcag gtgttgaatg ccttgagccg 240 ctgctcctga gatgcgatgg ccagcacggc tctgaggatc aatgcataag aaagcaggat 300 gaacgctgag tctacaccat aggtgaaaat gaccacaaaa agtccataga tgttgttaac 360 atgggtgtct ccacacgcca ctctcatgag atctggatgg aggcagtatg agtgatgcag 420 aactttgccc ttgcagaagg gcagccgttt taccaaaaag gggaaaggga aaagagtgat 480 gaaacttttg gtgaggatgc ccagacccat agccaggatg cggctgttgg tgagcacagt 540 ggcatagcgc agtgggtcac aaacagccac aaaacgatca aagctcatgg ccagcagtat 600 gcctgattcc atgaaagaga aagtgtggat gaagaacatc tggaccaagc aggcatcgaa 660 gccaacatgg cggtggttga agcagaaggt agcaagcaca gtgggaagtg tagacaagga 720 cactcccaga tcgttgagag agagcataga gaggaagcag tacatgggct ggtgcagagc 780 aggctcctga accaccagag cgaggatgct gaggttgcct atgatggaaa tcaggtagag 840 gatgcagaaa accagggcaa cccaggcatg gcctgtctgc atcccaggaa tgcctgtgag 900 ctggagtgtg gctggctgga agggggtacc attgacactc aacat 945 <210> 3400

Page 3799

069269_0225_SL.TXT <211> 314 <212> PRT <213> Felis catus

<400> 3400 Asn Gly Thr Pro Phe Gln Pro Ala Thr Leu Gln 15 Leu Met 1 Leu Ser Val 5 10 Thr Gly Ile Pro Gly Met Gln Thr Gly His Ala Trp Val Ala Leu Val 20 25 30 Phe Cys Ile Leu Tyr Leu Ile Ser Ile Ile Gly Asn Leu Ser Ile Leu 35 40 45 Ala Leu Val Val Gln Glu Pro Ala Leu His Gln Pro Met Tyr Cys Phe 50 55 60 Leu Ser Met Leu Ser Leu Asn Asp Leu Gly Val Ser Leu Ser Thr Leu 65 70 75 80 Pro Thr Val Leu Ala Thr Phe Cys Phe Asn His Arg His Val Gly Phe 85 90 95 Asp Ala Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Ser Phe Met 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Phe Val Ala Val 115 120 125 Cys Asp Pro Leu Arg Tyr Ala Thr Val Leu Thr Asn Ser Arg Ile Leu 130 135 140 Ala Met Gly Leu Gly Ile Leu Thr Lys Ser Phe Ile Thr Leu Phe Pro 145 150 155 160 Phe Pro Phe Leu Val Lys Arg Leu Pro Phe Cys Lys Gly Lys Val Leu 165 170 175 His His Ser Tyr Cys Leu His Pro Asp Leu Met Arg Val Ala Cys Gly 180 185 190

Page 3800

069269_0225_SL.TXT

Asp Thr His 195 Val Asn Asn Ile Tyr Gly Leu Phe Val Val Ile Phe Thr 200 205 Tyr Gly Val Asp Ser Ala Phe Ile Leu Leu Ser Tyr Ala Leu Ile Leu 210 215 220 Arg Ala Val Leu Ala Ile Ala Ser Gln Glu Gln Arg Leu Lys Ala Phe 225 230 235 240 Asn Thr Cys Met Ser His Ile Cys Ala Val Leu Ala Phe Tyr Val Pro 245 250 255 Ile Ile Thr Val Ser Met Ile His Arg Phe Trp Lys Ser Ala Pro Pro 260 265 270 Val Val His Val Met Met Ser Asn Val Tyr Leu Phe Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Ser Val Lys Thr Lys Glu Ile Arg Arg Gly 290 295 300 Ile Leu Lys Val Leu Tyr Lys Ser Gln Ser 305 310

<210> 3401 <211> 923 <212> DNA <213> Felis catus <400> 3401

atgggactgt tcaatgtcac tcatcctgct tccttcctcc tgaccggcat ccctggtctg 60 gagagctctc acgcctggct agcagggccc ctctgtgtca tgtatgctgt ggccctcgga 120 ggcaacactg tgatcctgca ggccgtgcga gtggagccca gcctccatga gcccatgtac 180 tacttcctgt ccatgctgtc cttcagtgac gtggccatgt ccatggccac actgcccacc 240 gtgctcagaa ccttctgcct caatgcccgc aacattgcct tcgatgcctg cctgattcag 300 atgtttctca ttcattcctt ctccatgatg gagtcgggca ttctgctggc catgagcttt 360 gatcgctatg tggccatttg tgatcccttg cactatgccg ccgtgctcac caatgaagtc 420

Page 3801

069269_0225_SL.TXT

attgccggaa taggcatagc tgtggctgct cggagcttca tcaccctcct tccccttctc 480 ttcctcttca agaggctgcc tatctgcaga tccaatgttc tttcccactc ctactgcctt 540 cacccagaca tgatgaagct ggcctgtgct gatatcacta tcaacagcat ctatggattc 600 tttgttcttg tatctacctt tggcatggac atgtttctta tcttcctctc ctatgtgctc 660 attctgcact cggtcatggc catcgcttcc cgagaggaac gcctgaaagt tctcaacaca 720 tgcatgtcac atatcttggc tgtacttgtg ttttacgtac cgatgattgg ggtctccaca 780 gtgcaccgct ttgggaagca tgccccgcgc tatgtacatg tcctcatgtc caatgtttac 840 ctctttgtac ctcctgtgct caaccctctc atttacagcg ccaagacaaa ggagatccgc 900 cgaaccattg tccgtatgtt tcg 923

<210> 3402 <211> 308 <212> PRT <213> Felis catus

<400> 3402 Val Thr His Pro Ala Ser Phe Leu Leu Thr Gly Met Gly 1 Leu Phe Asn 5 10 15 Ile Pro Gly Leu Glu Ser Ser His Ala Trp Leu Ala Gly Pro Leu Cys 20 25 30 Val Met Tyr Ala Val Ala Leu Gly Gly Asn Thr Val Ile Leu Gln Ala 35 40 45 Val Arg Val Glu Pro Ser Leu His Glu Pro Met Tyr Tyr Phe Leu Ser 50 55 60 Met Leu Ser Phe Ser Asp Val Ala Met Ser Met Ala Thr Leu Pro Thr 65 70 75 80 Val Leu Arg Thr Phe Cys Leu Asn Ala Arg Asn Ile Ala Phe Asp Ala 85 90 95 Cys Leu Ile Gln Met Phe Leu Ile His Ser Phe Ser Met Met Glu Ser 100 105 110

Page 3802

069269_0225_SL.TXT

Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asp 115 120 125 Pro Leu His Tyr Ala Ala Val Leu Thr Asn Glu Val Ile Ala Gly Ile 130 135 140 Gly Ile Ala Val Ala Ala Arg Ser Phe Ile Thr Leu Leu Pro Leu Leu 145 150 155 160 Phe Leu Phe Lys Arg Leu Pro Ile Cys Arg Ser Asn Val Leu Ser His 165 170 175 Ser Tyr Cys Leu His Pro Asp Met Met Lys Leu Ala Cys Ala Asp Ile 180 185 190 Thr Ile Asn Ser Ile Tyr Gly Phe Phe Val Leu Val Ser Thr Phe Gly 195 200 205 Met Asp Met Phe Leu Ile Phe Leu Ser Tyr Val Leu Ile Leu His Ser 210 215 220 Val Met Ala Ile Ala Ser Arg Glu Glu Arg Leu Lys Val Leu Asn Thr 225 230 235 240 Cys Met Ser His Ile Leu Ala Val Leu Val Phe Tyr Val Pro Met Ile 245 250 255 Gly Val Ser Thr Val His Arg Phe Gly Lys His Ala Pro Arg Tyr Val 260 265 270 His Val Leu Met Ser Asn Val Tyr Leu Phe Val Pro Pro Val Leu Asn 275 280 285 Pro Leu Ile Tyr Ser Ala Lys Thr Lys Glu Ile Arg Arg Thr Ile Val 290 295 300

Arg Met Phe Arg 305

Page 3803

069269_0225_SL.TXT <210> 3403 <211> 937 <212> DNA <213> Felis catus <400> 3403 taggcttaaa aaacattttg tgtagcctct tacgaatttc tttagtctta atggaataga 60 taattgggtt gagcattgga ggcacaaaga gatataccag ggacattaac ttgtgcacat 120 actcaggggc atgcttccca aatcgatgaa ccatggacac actaaccatg ggtacataga 180 agatgagcac agcacagatg tgtgacacac atgtattgag tgtcttaagc ctctcctcct 240 gggaggcaat ggccagtaca gagcgcagta tgagcacata ggagaggagg atgagcactg 300 agtctacacc aaaggcggag ataacaatga acaagccata catgctattg atggtggtat 360 ctccacaggg caggcggatc aggtctgggt gcaaacagta ggaatgggtt aacacattgg 420 ccttacagaa aggcagcctc ttcagaagga atggcaatgg aaagaccatg cagaagctgc 480 ggatgatgat ggatatgccc atgtgagcca cacggatatc agtgagcact gaagaataac 540 gcaaggggtt acagatggcc acatagcgat caaaactcat ggccagcagg atcccagatt 600 ctgtccagga gaaaaggtgg atgaagaaca tctgggtcaa gcaggcgtcg aaggcagtct 660 ccggggcatg aaagcacaag gcagccagta cggtgggcaa tgtagaaaag gacacgccca 720 ggtcattgac agacaacaga gacaggaagt agtacatagg ctggtgcaag ctctgctcct 780 cctttatgat gaagagaatt aggatgttac ccaggatgga gacagcataa agcagcaaga 840 ggagggccgc taaccagtgc tgtaggccct ccatctctgg gaagcctgtt agtgtgaagc 900 tggtggtgct agaggtatta gtcccaaaac ttcccat 937 <210> 3404 <211> 313 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (313)..(313) <223> Any amino acid

Page 3804

069269_0225_SL.TXT

<400> 3404 Gly Thr Asn Thr Ser Ser Thr Thr Ser Phe Thr 15 Leu Met 1 Gly Ser Phe 5 10 Thr Gly Phe Pro Glu Met Glu Gly Leu Gln His Trp Leu Ala Ala Leu 20 25 30 Leu Leu Leu Leu Tyr Ala Val Ser Ile Leu Gly Asn Ile Leu Ile Leu 35 40 45 Phe Ile Ile Lys Glu Glu Gln Ser Leu His Gln Pro Met Tyr Tyr Phe 50 55 60 Leu Ser Leu Leu Ser Val Asn Asp Leu Gly Val Ser Phe Ser Thr Leu 65 70 75 80 Pro Thr Val Leu Ala Ala Leu Cys Phe His Ala Pro Glu Thr Ala Phe 85 90 95 Asp Ala Cys Leu Thr Gln Met Phe Phe Ile His Leu Phe Ser Trp Thr 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Ser Ser Val Leu Thr Asp Ile Arg Val Ala 130 135 140 His Met Gly Ile Ser Ile Ile Ile Arg Ser Phe Cys Met Val Phe Pro 145 150 155 160 Leu Pro Phe Leu Leu Lys Arg Leu Pro Phe Cys Lys Ala Asn Val Leu 165 170 175 Thr His Ser Tyr Cys Leu His Pro Asp Leu Ile Arg Leu Pro Cys Gly 180 185 190 Asp Thr Thr Ile Asn Ser Met Tyr Gly Leu Phe Ile Val Ile Ser Ala 195 200 205

Page 3805

069269_0225_SL.TXT

Phe Gly Val Asp Ser Val Leu Ile Leu Leu Ser Tyr Val Leu Ile Leu 210 215 220 Arg Ser Val Leu Ala Ile Ala Ser Gln Glu Glu Arg Leu Lys Thr Leu 225 230 235 240 Asn Thr Cys Val Ser His Ile Cys Ala Val Leu Ile Phe Tyr Val Pro 245 250 255 Met Val Ser Val Ser Met Val His Arg Phe Gly Lys His Ala Pro Glu 260 265 270 Tyr Val His Lys Leu Met Ser Leu Val Tyr Leu Phe Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Ser Ile Lys Thr Lys Glu Ile Arg Lys Arg 290 295 300 Leu His Lys Met Phe Phe Lys Pro Xaa

305 310

<210> 3405 <211> 909 <212> DNA <213> Felis catus <400> 3405 tagtattttg caaagcctcc gacgaatctc tttggttttg atggaataaa taatggggtt 60 gagcatagga ggcacaaaga gatagatcag ggacatgagt gtatgtacat actgtggggc 120 atgcctccca tagcgagcaa ccatggacac accaaccatg ggcacataga acatgagcac 180 agcacacaag tgagacacac atgtattcag tgtcttaagt ctttcctccc aggatgcaat 240 gacaagtaca gagcgcagta tgagcacgta agaaagaaga atgagtgcag aatccagacc 300 aaagttacag atgacaatga attgaccata aatattattg atggtgatgt caccacaggg 360 caagcggatc agatctggat gcaggcagta agcatgggag agtacattgg ccttgcagaa 420 gggcaacctc ttcagaagga aaggcagtgg gaaaaccaca cagaaactgc ggatgataac 480 agccatgccc atacacacca cacaggcacc agtaagaact gtggcataac gcagtgggtt 540

Page 3806

069269_0225_SL.TXT acagatggcc acatagcggt caaagctcat aaccaacaga atccccgact ctatgaagga gaagaggtgg ataaagaaca tttgagccat gcaagaatca aagctgatct tctgtaagtg gaagcaaaat gtggccaaca ccgtgggcag tgtggaaaag gacacaccta ggtcattaac tgatagcagg gacaagaaat agtacatagg ctgatgcaaa ctctgttcct ccttgataat gaaaaggata agggcatttc ccacaatgga gacagtgtag agggtaccaa ggagcagaaa cacatagtgt tgggaggtcc ccagccctga caaccctgtc agggtaaagg gaggcaactc tgagctgtt

600

660

720

780

840

900

909 <210> 3406 <211> 303 <212> PRT <213> Felis catus

<400> 3406 Pro Pro Phe Thr Leu Thr Gly Leu Ser 10 Gly 15 Leu Asn 1 Ser Ser Glu Leu 5 Gly Thr Ser Gln His Tyr Val Phe Leu Leu Leu Gly Thr Leu Tyr Thr 20 25 30 Val Ser Ile Val Gly Asn Ala Leu Ile Leu Phe Ile Ile Lys Glu Glu 35 40 45 Gln Ser Leu His Gln Pro Met Tyr Tyr Phe Leu Ser Leu Leu Ser Val 50 55 60 Asn Asp Leu Gly Val Ser Phe Ser Thr Leu Pro Thr Val Leu Ala Thr 65 70 75 80 Phe Cys Phe His Leu Gln Lys Ile Ser Phe Asp Ser Cys Met Ala Gln 85 90 95 Met Phe Phe Ile His Leu Phe Ser Phe Ile Glu Ser Gly Ile Leu Leu 100 105 110 Val Met Ser Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr 115 120 125

Page 3807

069269_0225_SL.TXT

Ala Thr Val 130 Leu Thr Gly Ala Cys Val Val Cys Met Gly Met Ala Val 135 140 Ile Ile Arg Ser Phe Cys Val Val Phe Pro Leu Pro Phe Leu Leu Lys 145 150 155 160 Arg Leu Pro Phe Cys Lys Ala Asn Val Leu Ser His Ala Tyr Cys Leu 165 170 175 His Pro Asp Leu Ile Arg Leu Pro Cys Gly Asp Ile Thr Ile Asn Asn 180 185 190 Ile Tyr Gly Gln Phe Ile Val Ile Cys Asn Phe Gly Leu Asp Ser Ala 195 200 205 Leu Ile Leu Leu Ser Tyr Val Leu Ile Leu Arg Ser Val Leu Val Ile 210 215 220 Ala Ser Trp Glu Glu Arg Leu Lys Thr Leu Asn Thr Cys Val Ser His 225 230 235 240 Leu Cys Ala Val Leu Met Phe Tyr Val Pro Met Val Gly Val Ser Met 245 250 255 Val Ala Arg Tyr Gly Arg His Ala Pro Gln Tyr Val His Thr Leu Met 260 265 270 Ser Leu Ile Tyr Leu Phe Val Pro Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Ile Lys Thr Lys Glu Ile Arg Arg Arg Leu Cys Lys Ile Leu 290 295 300

<210> 3407 <211> 948 <212> DNA <213> Felis catus <400> 3407

Page 3808

069269_0225_SL.TXT

tcaggactta accctaaaga gcatcttgag gagcctgcga cgtatctcct ttgtcttaat 60 ggagtagatg ataggattga gcatgggagg cacaaagagg tagagaatag acatgaggat 120 atagacagca tggggcaggc cagcatcaaa acgatgcaca atggacacac ttaccatggg 180 cacatagaag atgagcacag ctaggatgtg ggacacacat gtgttcagtg tcttgatgcg 240 cttttctccg gaggcaatgg caagcactga tcgcaagatt agtacatagg agaggagaat 300 gagtgcagag tccaggccaa aggtgaatag cacaatggac agcccatagt ggctattgag 360 ggagacatca gtacatgcca gcttaatcat atccacatga aggcagtagg catgggagag 420 gatgttctgg gagtggcaga aggggagtct gtgcagcagc agtgggaaga caaggataag 480 ggcaaagctt cggaggacag cacacagtcc cattgccaca atgcgggcat tagtgagcac 540 tgtagcatag cgcagtgggt ggcagatggc aacatagcga tcaaagctca tagccagaag 600 gatgccagac tctgtccaag agaagaggtg gatgaaaaac atttgggcca agcaggcatt 660 aaaggcaatc accctggcat ggaaacagag ggcagccagc acggtcggca atgtggaaaa 720 ggacactccc aagtcattga ctgaaagtag agataaaaag tagtacatgg gctggtgcaa 780 gctctgctcc tccttaacaa tgaggaggat cagggtgttt cccacaatgg agatggtgta 840 gagcagcaga agagggaagg atagccagga ttccatggtt tccattcctg ggaagcccgt 900 caagataaag gtgggagcat cagaggcatt gattttgaag ttacccat 948

<210> 3408 <211> 315 <212> PRT <213> Felis catus

<400> 3408 Met 1 Gly Asn Phe Lys Ile Asn Ala Ser Asp Ala Pro Thr Phe Ile Leu 5 10 15 Thr Gly Phe Pro Gly Met Glu Thr Met Glu Ser Trp Leu Ser Phe Pro 20 25 30 Leu Leu Leu Leu Tyr Thr Ile Ser Ile Val Gly Asn Thr Leu Ile Leu 35 40 45 Leu Ile Val Lys Glu Glu Gln Ser Leu His Gln Pro Met Tyr Tyr Phe Page 3809

50 55 069269_0225_SL.TXT 60 Leu Ser Leu Leu Ser Val Asn Asp Leu Gly Val Ser Phe Ser Thr Leu 65 70 75 80 Pro Thr Val Leu Ala Ala Leu Cys Phe His Ala Arg Val Ile Ala Phe 85 90 95 Asn Ala Cys Leu Ala Gln Met Phe Phe Ile His Leu Phe Ser Trp Thr 100 105 110 Glu Ser Gly Ile Leu Leu Ala Met Ser Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg Tyr Ala Thr Val Leu Thr Asn Ala Arg Ile Val 130 135 140 Ala Met Gly Leu Cys Ala Val Leu Arg Ser Phe Ala Leu Ile Leu Val 145 150 155 160 Phe Pro Leu Leu Leu His Arg Leu Pro Phe Cys His Ser Gln Asn Ile 165 170 175 Leu Ser His Ala Tyr Cys Leu His Val Asp Met Ile Lys Leu Ala Cys 180 185 190 Thr Asp Val Ser Leu Asn Ser His Tyr Gly Leu Ser Ile Val Leu Phe 195 200 205 Thr Phe Gly Leu Asp Ser Ala Leu Ile Leu Leu Ser Tyr Val Leu Ile 210 215 220 Leu Arg Ser Val Leu Ala Ile Ala Ser Gly Glu Lys Arg Ile Lys Thr 225 230 235 240 Leu Asn Thr Cys Val Ser His Ile Leu Ala Val Leu Ile Phe Tyr Val 245 250 255 Pro Met Val Ser Val Ser Ile Val His Arg Phe Asp Ala Gly Leu Pro

Page 3810

260

069269_0225_SL.TXT 265 270

His Ala Val Tyr Ile Leu Met Ser Ile Leu Tyr Leu Phe Val Pro Pro 275 280 285 Met Leu Asn Pro Ile Ile Tyr Ser Ile Lys Thr Lys Glu Ile Arg Arg 290 295 300 Arg Leu Leu Lys Met Leu Phe Arg Val Lys Ser

305 310 315 <210> 3409 <211> 945 <212> DNA <213> Felis catus <400> 3409

aacatcagtg atgacagtct cccaggcaca ctcatcctta ctgggatccc aggactggag 60 tgggcccacg tctggatcgc catccccttc tgcaccatgt atctggtagc gctgactggg 120 aatgctgccc tcatccttgt cattgtgaca gacagggctc ttcatgcacc catgtacctc 180 ttcctgtgcc ttctctcact cactgacctg gctctcagct ccactactgt gcccaagaca 240 ttagccattt tgtggtttta tactggagag atttcctttg gtggatgcct ggcccagatg 300 ttttgtgtcc attctatcta tgctctagag tcctcagttc ttctcgccat ggcctttgat 360 cgctatgtgg ctatctgcaa cccactgaga tacacaacta ttctcaacca tactgtcata 420 ggcaaaattg gacttgccag catattccgt agcatagttt ttgtctcccc attcatcttc 480 ttgttgaggc gactgcctta ctgtggtcac catgtcatgg cccacacata ctgtgagcac 540 atgggcatcg ctcgcctggc ctgtgccaac atcactgtca atattgtcta tgggctgact 600 gtggccctgt tggccgtggg tctggattcc atcctcattg ccatttccta cggctttatc 660 ctccatgctg tcttccgcct tccatctcaa gatgccaggc acaaggctct gagtacctgt 720 ggctcccacc tgggggtcat cttggtcttc tacattcctg ccttcttctc cttcctcacc 780 caccgttttg gccagcaccg agtccccaag aatgtgcaca tttttctggc caacctgtat 840 gtgctggtgc ctcctgtgct caacccgatc atctatgggg ctaggaccaa ggagattcgg 900 agccgacttc tgaggctgct tcacttgagg agggtctcag tatga 945

Page 3811

069269_0225_SL.TXT <210> 3410 <211> 314 <212> PRT <213> Felis catus

<400> 3410 Asn 1 Ile Ser Asp Asp 5 Ser Leu Pro Gly Thr Leu Ile Leu Thr Gly Ile 10 15 Pro Gly Leu Glu Trp Ala His Val Trp Ile Ala Ile Pro Phe Cys Thr 20 25 30 Met Tyr Leu Val Ala Leu Thr Gly Asn Ala Ala Leu Ile Leu Val Ile 35 40 45 Val Thr Asp Arg Ala Leu His Ala Pro Met Tyr Leu Phe Leu Cys Leu 50 55 60 Leu Ser Leu Thr Asp Leu Ala Leu Ser Ser Thr Thr Val Pro Lys Thr 65 70 75 80 Leu Ala Ile Leu Trp Phe Tyr Thr Gly Glu Ile Ser Phe Gly Gly Cys 85 90 95 Leu Ala Gln Met Phe Cys Val His Ser Ile Tyr Ala Leu Glu Ser Ser 100 105 110 Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125 Leu Arg Tyr Thr Thr Ile Leu Asn His Thr Val Ile Gly Lys Ile Gly 130 135 140 Leu Ala Ser Ile Phe Arg Ser Ile Val Phe Val Ser Pro Phe Ile Phe 145 150 155 160 Leu Leu Arg Arg Leu Pro Tyr Cys Gly His His Val Met Ala His Thr 165 170 175

Page 3812

069269_0225_SL.TXT

Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala Asn Ile Thr 190 180 185 Val Asn Ile Val Tyr Gly Leu Thr Val Ala Leu Leu Ala Val Gly Leu 195 200 205 Asp Ser Ile Leu Ile Ala Ile Ser Tyr Gly Phe Ile Leu His Ala Val 210 215 220 Phe Arg Leu Pro Ser Gln Asp Ala Arg His Lys Ala Leu Ser Thr Cys 225 230 235 240 Gly Ser His Leu Gly Val Ile Leu Val Phe Tyr Ile Pro Ala Phe Phe 245 250 255 Ser Phe Leu Thr His Arg Phe Gly Gln His Arg Val Pro Lys Asn Val 260 265 270 His Ile Phe Leu Ala Asn Leu Tyr Val Leu Val Pro Pro Val Leu Asn 275 280 285 Pro Ile Ile Tyr Gly Ala Arg Thr Lys Glu Ile Arg Ser Arg Leu Leu 290 295 300 Arg Leu Leu His Leu Arg Arg Val Ser Val 305 310 <210> 3411 <211> 945 <212> DNA <213> Felis catus <400> 3411 aacatcagtg atgacagtct cccaggcaca ctcatcctga cgggcatccc agggctggag tgggcccacg tctggatcgc catccccttc tgcgccatgt atctggtagc actggctggg aatgctgccc tcatcctggt cattgtgaca gacagtgctc ttcatgcacc catgtacctc ttcctgtgcc ttctctcact cactgacctg gctctcagct ctgtcactgt gcccaagatg ctggccattt tgtggcttca tgctggagag atttcctttg gtggatgcct ggcccagatg

120

180

240

300

Page 3813

069269_0225_SL.TXT

ttttgtgtcc attctatcta taccctggag tctttagttc ttcttgccat ggcctttgat 360 cgctacgtgg ccatctgcaa cccactgaga tacacaacca ttctcaacca tacagtcata 420 ggcaaaattg gccttgctgg gctgtgccgt agtgtggcca ttgtgtcccc gttcatcttc 480 ttgttgaggc gactgcctta ctgtggtcac catgtcatgg cccacacata ctgtgagcac 540 atgggcatcg ctcgcctggc ctgtgccaac atcactgtca atattgtcta tgggctgact 600 gtggccctgc tggccatggg tctggatgcc atcctcattg ccatttccta cggctttatc 660 ctccatgctg tcttccgcct tccatctcaa gatgccaggc acaaggctct gagtacctgt 720 ggctcccacc tgggggtcat cctggtcttc tacattcctg ccttcttctc cttcctcacc 780 caccgctttg gccagcaccg agtccccaag aatgtgcaca tttttctggc caacctgtat 840 gtgctggtgc ctcctgtgct caacccgatc atctatgggg ctaggaccaa ggagattcgg 900 agccgacttc tgaggctgct acatatgagg aaggtctcat tgtga 945

<210> 3412 <211> 314 <212> PRT <213> Felis catus <400> 3412

Asn Ile Ser Asp Asp Ser Leu Pro Gly Thr Leu Ile Leu Thr Gly Ile 1 5 10 15 Pro Gly Leu Glu Trp Ala His Val Trp Ile Ala Ile Pro Phe Cys Ala 20 25 30 Met Tyr Leu Val Ala Leu Ala Gly Asn Ala Ala Leu Ile Leu Val Ile 35 40 45 Val Thr Asp Ser Ala Leu His Ala Pro Met Tyr Leu Phe Leu Cys Leu 50 55 60 Leu Ser Leu Thr Asp Leu Ala Leu Ser Ser Val Thr Val Pro Lys Met 65 70 75 80 Leu Ala Ile Leu Trp Leu His Ala Gly Glu Ile Ser Phe Gly Gly Cys 85 90 95

Page 3814

069269_0225_SL.TXT

Leu Ala Gln Met 100 Phe Cys Val His Ser Ile Tyr Thr Leu Glu Ser Leu 105 110 Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125 Leu Arg Tyr Thr Thr Ile Leu Asn His Thr Val Ile Gly Lys Ile Gly 130 135 140 Leu Ala Gly Leu Cys Arg Ser Val Ala Ile Val Ser Pro Phe Ile Phe 145 150 155 160 Leu Leu Arg Arg Leu Pro Tyr Cys Gly His His Val Met Ala His Thr 165 170 175 Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala Asn Ile Thr 180 185 190 Val Asn Ile Val Tyr Gly Leu Thr Val Ala Leu Leu Ala Met Gly Leu 195 200 205 Asp Ala Ile Leu Ile Ala Ile Ser Tyr Gly Phe Ile Leu His Ala Val 210 215 220 Phe Arg Leu Pro Ser Gln Asp Ala Arg His Lys Ala Leu Ser Thr Cys 225 230 235 240 Gly Ser His Leu Gly Val Ile Leu Val Phe Tyr Ile Pro Ala Phe Phe 245 250 255 Ser Phe Leu Thr His Arg Phe Gly Gln His Arg Val Pro Lys Asn Val 260 265 270 His Ile Phe Leu Ala Asn Leu Tyr Val Leu Val Pro Pro Val Leu Asn 275 280 285 Pro Ile Ile Tyr Gly Ala Arg Thr Lys Glu Ile Arg Ser Arg Leu Leu 290 295 300

Page 3815

069269_0225_SL.TXT

Arg Leu Leu His Met Arg Lys Val Ser Leu 305 310 <210> 3413 <211> 949 <212> DNA <213> Felis catus <400> 3413

atgtcagctt ccaacatcag tgaggatagt ctcccaggca cactcatcct gacgggcatc 60 ccagggctgg agtgggccca tgtctggatc gccatcccct tctgcgccat gtatcttgta 120 gcgctggctg ggaatgctgc cctcatcctg gtcattgtga cagacagtgc tcttcatgca 180 cccatgtacc tcttcctgtg ccttctttcg ctcaccgacc tggctctcag ctccaccacg 240 gtgcctaaga tgctgtccac tttatggctg catgctggag agatttcctt tggtggatgc 300 ctggcccaaa tgttttgtgt ccattctatc tatgctctgg agtcctcagt tcttctagcc 360 atggcctttg atcgctacgt ggcaatctgc aacccactga gatacacaac tattctcaac 420 catagcatca taggcatgat tagccttgtt gggctattcc gtagtgtggc cattgtgacc 480 ccattcatct tcttgctgag gcgactgcct tactgtggtc accatgtcat ggcccacaca 540 tactgtgagc acatgggcat cgctcgcctg gcctgtgcca atatcactgt caatattgtc 600 tatgggctga ctgtggccct gctggccatg ggtctggatg ccatcctcat tgccatttcc 660 tacggcttta tcctccatgc tgtcttccgc cttccatctc aagatgccag gcacaaggct 720 ctgagtacct gtggctccca cctgggggtc atcctggtct tctacattcc tgccttcttc 780 tccttcctca cccaccgctt tggccagcac cgagtcccca agaatgtgca catttttctg 840 gccaacctgt acgtgctggt gcctcctgtg ctcaacccga tcatctatgg ggctaggacc 900 aaggagattc ggagccgact tctgaggctg cttcacttgg ggaaaattt 949

<210> 3414 <211> 317 <212> PRT <213> Felis catus <220>

<221> MOD RES

Page 3816

069269_0225_SL.TXT <222> (317)..(317) <223> Any amino acid

<400> 3414 Met 1 Ser Ala Ser Asn Ile Ser Glu 5 Asp Ser 10 Leu Pro Gly Thr Leu Ile 15 Leu Thr Gly Ile Pro Gly Leu Glu Trp Ala His Val Trp Ile Ala Ile 20 25 30 Pro Phe Cys Ala Met Tyr Leu Val Ala Leu Ala Gly Asn Ala Ala Leu 35 40 45 Ile Leu Val Ile Val Thr Asp Ser Ala Leu His Ala Pro Met Tyr Leu 50 55 60 Phe Leu Cys Leu Leu Ser Leu Thr Asp Leu Ala Leu Ser Ser Thr Thr 65 70 75 80 Val Pro Lys Met Leu Ser Thr Leu Trp Leu His Ala Gly Glu Ile Ser 85 90 95 Phe Gly Gly Cys Leu Ala Gln Met Phe Cys Val His Ser Ile Tyr Ala 100 105 110 Leu Glu Ser Ser Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala 115 120 125 Ile Cys Asn Pro Leu Arg Tyr Thr Thr Ile Leu Asn His Ser Ile Ile 130 135 140 Gly Met Ile Ser Leu Val Gly Leu Phe Arg Ser Val Ala Ile Val Thr 145 150 155 160 Pro Phe Ile Phe Leu Leu Arg Arg Leu Pro Tyr Cys Gly His His Val 165 170 175 Met Ala His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys 180 185 190

Page 3817

Ala Asn Ile 195 Thr Val Asn Ile 069269_0225_SL.TXT Val Tyr Gly Leu Thr Val 200 205 Ala Leu Leu Ala Met Gly Leu Asp Ala Ile Leu Ile Ala Ile Ser Tyr Gly Phe Ile 210 215 220 Leu His Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg His Lys Ala 225 230 235 240 Leu Ser Thr Cys Gly Ser His Leu Gly Val Ile Leu Val Phe Tyr Ile 245 250 255 Pro Ala Phe Phe Ser Phe Leu Thr His Arg Phe Gly Gln His Arg Val 260 265 270 Pro Lys Asn Val His Ile Phe Leu Ala Asn Leu Tyr Val Leu Val Pro 275 280 285 Pro Val Leu Asn Pro Ile Ile Tyr Gly Ala Arg Thr Lys Glu Ile Arg 290 295 300 Ser Arg Leu Leu Arg Leu Leu His Leu Gly Lys Ile Xaa 305 310 315

<210> 3415 <211> 1020 <212> DNA <213> Felis catus <400> 3415

tcattcactg ctatgggagg ccctctcagg gcttacaccc cttatggccc cgacccagca 60 caatcgaagc aagtgcctga gcctctgagc gatctgttgg gtacgtactc catagaccac 120 agggttcagg gcagggggca ccaccacata caggttagcc agtaggatgt ggatgtggcc 180 gggcaccgtg tggcggccga aacggtgggc caggaaagag aagagagcgg gtgtgtagaa 240 gagagtgatg acactggcat gggccccaca ggtacccaag gctttgcagc gggcactgtg 300 ggacggcagg cgacagacag cacggagaat gaaggcatag gaagtggcga tgagcccgaa 360 gtccagtgct ggggatagaa gtgtggtggc tagtccgtac caaacgttgg ggcgcgtgtc 420

Page 3818

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accacatgcc agccgagcca cacccatgtg ttcacagtag gtgtggggga gctcccgctg 480 cccacagtaa ggcagtcttt ggagcagggc cacagggggt gccatgacac aggcaccacg 540 ggtcacggca gccaccgcca ctccacccac cacacgctgt gtcagcaatg ccccatagcg 600 cagaggctga cagatggcca catagcggtc cacggccatg gccaggagca ctgaagattc 660 agcaatgaag gccacatggg taacaaagag ctgagctagg caggccgcaa aagagatctc 720 tgctgacagg ccccacagca cagccagagc tttgggtacc gtggatgtgg ccagaaccaa 780 gtcagcagct gccagaagcc ccagcagctg gtacatgggt gcctgaagtg tcttatcagc 840 tgccaccagc cccagtagaa ggacattccc tgccaaagcc gccatgtaca gcagacatac 900 aggcaccgca agccaggcat gcagggtctc cagtcctggc acccccagca ggacaaaggg 960 accgggccca gagatgagca cagtctggtt gaaagcagcc agtacaggat ccatttccat 1020

<210> 3416 <211> 339 <212> PRT <213> Felis catus <400> 3416

Met Glu Met Asp Pro Val Leu Ala Ala Phe Asn Gln Thr Val Leu Ile 1 5 10 15 Ser Gly Pro Gly Pro Phe Val Leu Leu Gly Val Pro Gly Leu Glu Thr 20 25 30 Leu His Ala Trp Leu Ala Val Pro Val Cys Leu Leu Tyr Met Ala Ala 35 40 45 Leu Ala Gly Asn Val Leu Leu Leu Gly Leu Val Ala Ala Asp Lys Thr 50 55 60 Leu Gln Ala Pro Met Tyr Gln Leu Leu Gly Leu Leu Ala Ala Ala Asp 65 70 75 80 Leu Val Leu Ala Thr Ser Thr Val Pro Lys Ala Leu Ala Val Leu Trp 85 90 95 Gly Leu Ser Ala Glu Ile Ser Phe Ala Ala Cys Leu Ala Gln Leu Phe Page 381 9

100

069269_0225_SL.TXT 105 110

Val Thr His 115 Val Ala Phe Ile Ala Glu Ser Ser Val Leu Leu Ala Met 120 125 Ala Val Asp Arg Tyr Val Ala Ile Cys Gln Pro Leu Arg Tyr Gly Ala 130 135 140 Leu Leu Thr Gln Arg Val Val Gly Gly Val Ala Val Ala Ala Val Thr 145 150 155 160 Arg Gly Ala Cys Val Met Ala Pro Pro Val Ala Leu Leu Gln Arg Leu 165 170 175 Pro Tyr Cys Gly Gln Arg Glu Leu Pro His Thr Tyr Cys Glu His Met 180 185 190 Gly Val Ala Arg Leu Ala Cys Gly Asp Thr Arg Pro Asn Val Trp Tyr 195 200 205 Gly Leu Ala Thr Thr Leu Leu Ser Pro Ala Leu Asp Phe Gly Leu Ile 210 215 220 Ala Thr Ser Tyr Ala Phe Ile Leu Arg Ala Val Cys Arg Leu Pro Ser 225 230 235 240 His Ser Ala Arg Cys Lys Ala Leu Gly Thr Cys Gly Ala His Ala Ser 245 250 255 Val Ile Thr Leu Phe Tyr Thr Pro Ala Leu Phe Ser Phe Leu Ala His 260 265 270 Arg Phe Gly Arg His Thr Val Pro Gly His Ile His Ile Leu Leu Ala 275 280 285 Asn Leu Tyr Val Val Val Pro Pro Ala Leu Asn Pro Val Val Tyr Gly 290 295 300 Val Arg Thr Gln Gln Ile Ala Gln Arg Leu Arg His Leu Leu Arg Leu

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305 310 315 320

Cys Trp Val Gly Ala Ile Arg Gly Val Ser Pro Glu Arg Ala Ser His 325 330 335

Ser Ser Glu <210> 3417 <211> 931 <212> DNA <213> Felis catus <400> 3417

ccttggtgga aaacaaaaat atgaccttat ctcggatctg cttggtcttc actccataga 60 caatggggtt gagtgcaggg ggaataacta tgtagaggtt ggcaaacagg atgtggaaag 120 tgcgggagac attgtgccca aagcgatgcg caaggatgga gaaaaaggcg ggtgtataaa 180 acatgaggat gacacagaca tgggaaccac acgtgccaag ggctttgtga cgggcatccc 240 gggagggaag gcggaagacg gcacggagga tgaggctgta agaaacggca atgagaatca 300 catctgagat gaccgtcatg atggggacac caaagccata ccagatgttg acggagatgt 360 cagcacaggc gagccgggca acacctatgt gctcacagta tgtgtgcggt atgatgcgtg 420 tcctgcagaa aggcaggcgt gtgagcaaga atacaactgg caggataatg cagaagcttc 480 gaaaggagat gcccactgca atcttgatga tggtcctggg agtcagaata gtggtgtacc 540 tcaggggaga gcagatggcc acgtagcggt caaatgccat ggccatcagg atggctgaat 600 ccaggacaaa gctgcagtgc agaaagaata actgggtcag acaaccagga aaactgattt 660 tctggggacc aagccagaag atggtaaggg ttttggggac acaagtggta gacagtatca 720 gatctgtcat ggccagcatg gaaaggaaaa agaacatggg tgcatgaaga ctatgttcca 780 cagcaatgag gtagagaagg atactattgc ccacaatggc cgcgagatag ataaagcaga 840 aggggatgct gatccagacg tggtactgcc cgaggccagg gatgcccaaa agggtgaagt 900 cacctgtgtg gtcgttactc aggttgtaca t 931

<210> 3418 <211> 311

Page 3821

069269_0225_SL.TXT <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (311)..(311) <223> Any amino acid

<400> 3418 Met 1 Tyr Asn Leu Ser 5 Asn Asp His Thr Gly Asp Phe Thr Leu Leu Gly 10 15 Ile Pro Gly Leu Gly Gln Tyr His Val Trp Ile Ser Ile Pro Phe Cys 20 25 30 Phe Ile Tyr Leu Ala Ala Ile Val Gly Asn Ser Ile Leu Leu Tyr Leu 35 40 45 Ile Ala Val Glu His Ser Leu His Ala Pro Met Phe Phe Phe Leu Ser 50 55 60 Met Leu Ala Met Thr Asp Leu Ile Leu Ser Thr Thr Cys Val Pro Lys 65 70 75 80 Thr Leu Thr Ile Phe Trp Leu Gly Pro Gln Lys Ile Ser Phe Pro Gly 85 90 95 Cys Leu Thr Gln Leu Phe Phe Leu His Cys Ser Phe Val Leu Asp Ser 100 105 110 Ala Ile Leu Met Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Arg Tyr Thr Thr Ile Leu Thr Pro Arg Thr Ile Ile Lys Ile 130 135 140 Ala Val Gly Ile Ser Phe Arg Ser Phe Cys Ile Ile Leu Pro Val Val 145 150 155 160 Phe Leu Leu Thr Arg Leu Pro Phe Cys Arg Thr Arg Ile Ile Pro His 165 170 175

Page 3822

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Thr Tyr Cys Glu 180 His Ser Val Asn 195 Ile Trp Ser Asp 210 Val Ile Leu Val 225 Phe Arg Leu Pro Cys Gly Ser His Val 245 Phe Ser Ile Leu 260 Ala His Ile Leu 275 Phe Ala Pro Ile 290 Val Tyr Gly Phe 305 Leu Phe Ser Thr

Ile Gly Val Ala 185 Arg Leu Tyr Gly Phe 200 Gly Val Pro Ile Ala 215 Val Ser Tyr Ser Ser 230 Arg Asp Ala Arg His 235 Cys Val Ile Leu Met 250 Phe His Arg Phe Gly 265 His Asn Asn Leu Tyr 280 Ile Val Ile Val Lys 295 Thr Lys Gln Ile Lys Xaa

310

Ala Cys Ala 190 Asp Ile Ile Met 205 Thr Val Ile Leu 220 Ile Leu Arg Ala Lys Ala Leu Gly Thr 240 Tyr Thr Pro Ala 255 Phe Val Ser Arg 270 Thr Phe Pro Pro 285 Ala Leu Asn Arg 300 Asp Lys Val Ile

<210> 3419 <211> 843 <212> DNA <213> Felis catus <400> 3419 cacatgtgga tctccatcgc atcctgatct gtgtggtggc tctgtgttgg ctttttggga atcttctgat ttgatgatgt cttctgcctg atgtacctgg agtggagcaa agtcttcatg tctgattcta tccacatcca ggacatctct tggtggctgt ttgctgtgtc aggaaatgtt aacatatgta cctcttcctc cagcacccaa agccctgagc ataacccagc tcttctttat

120

180

240

Page 3823

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gcattttgcc tttgtggtgg aatcaggcat tctcttggcc atggtttttg atcactatgt 300 ggccatctgc tacccacgga ggtacaccat cattcttagc catggtgtca tcggcaaaat 360 agggcgtgtt gtagtgctca ggagttttgc aactgtttgc ccctttatct tcctagtgag 420 gagcctgctc ttctgccaga aaaacatcat tgcccacacg ttctgtgaac acatggggct 480 ggctaagttg gcttatgctg atatcaccgt caacatttgg tatggaatct ctgtgccatt 540 actcagtgta atgctagata tggtgacaat agtcatctcc tataggctca ttctccaggc 600 ggtcttcagg ctgccatccc atgatgtgca gatgaaaaca ttcagcacct gtggttccca 660 tgtctgtgtc atcctcatgt tctaccttcc tgggattgtc agtgtcattg ctcaacactt 720 tggccgaaaa atccccaagc atgtccacat cctgttggct gatctctatg ttctcgttct 780 ccccgtgatg aacccaatta tctatggagt aaagaccaaa cagatttgtg aaagagtggt 840

ctt 843 <210> 3420 <211> 217 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (217)..(217) <223> Any amino acid

<400> 3420 Met Met Trp Thr 1 Ser 5 Leu Gly Gly Cys Ile Thr Gln Leu Phe Phe Met 10 15 His Phe Ala Phe Val Val Glu Ser Gly Ile Leu Leu Ala Met Val Phe 20 25 30 Asp His Tyr Val Ala Ile Cys Tyr Pro Arg Arg Tyr Thr Ile Ile Leu 35 40 45 Ser His Gly Val Ile Gly Lys Ile Gly Arg Val Val Val Leu Arg Ser 50 55 60 Phe Ala Thr Val Cys Pro Phe Ile Phe Leu Val Arg Ser Leu Leu Phe Page 3824

069269_0225_SL.TXT

Cys Gln Lys Asn Ile Ile Ala His Thr Phe Cys Glu His Met Gly Leu 85 90 95 Ala Lys Leu Ala Tyr Ala Asp Ile Thr Val Asn Ile Trp Tyr Gly Ile 100 105 110 Ser Val Pro Leu Leu Ser Val Met Leu Asp Met Val Thr Ile Val Ile 115 120 125 Ser Tyr Arg Leu Ile Leu Gln Ala Val Phe Arg Leu Pro Ser His Asp 130 135 140 Val Gln Met Lys Thr Phe Ser Thr Cys Gly Ser His Val Cys Val Ile 145 150 155 160 Leu Met Phe Tyr Leu Pro Gly Ile Val Ser Val Ile Ala Gln His Phe 165 170 175 Gly Arg Lys Ile Pro Lys His Val His Ile Leu Leu Ala Asp Leu Tyr 180 185 190 Val Leu Val Leu Pro Val Met Asn Pro Ile Ile Tyr Gly Val Lys Thr 195 200 205 Lys Gln Ile Cys Glu Arg Val Val Xaa 210 215

<210> 3421 <211> 949 <212> DNA <213> Felis catus <400> 3421 tcacttcatc cctttaggaa agagtaggag aatgactttg tccctgatct gcttggtttt tacaccataa atgatgggat tgagtgcagg agggattgcc acatagaggt tggcaaatat gatgtgaaag gtgcaagaga tattgtgtcc gaagcgatga gtgaggacag agaatatggc tggtgtgtag aatatgagaa tgacacagac atgggaaccg caggtgctga gggctttctg Page 3825

120

180

240

069269_0225_SL.TXT gtgggcatct ctggatggaa gatggaaaac aatgaggacc aggtctgaga taatagtcat gatggagatg tcagcacagg cgagtcgggc gatgatacgt gacttgcaga agggcaaacg accaaagctc cgacccacaa tgcccaccat acttgtgtat ctcaaagggc agcaaatggc aatggcggag tccagaaaaa agctgaagtg aaaagtgatt ttctgagctt tcaaccagaa gcataatacg aggtctgcag aggccaacat gctgtggtcc acagtgatga ggtaaagaag gatagtgaag aaaggaatcc caatccagat caaaatgaaa gagcctggat tgaaacttgt <210> 3422 <211> 315 <212> PRT <213> Felis catus agcatgaagg atgagagcat aggaaatacc cacaggcaca gcaaaaccat accagatgtt aacccctata tgttcacagt atgtgtgagg cttcaccagg aaaacaacag gcaaaatgac gatcttgaca attgtccttg gtgtcaaaac catgtaacgg ccaaatgcca tgcccaacaa aagaaagaac aactgggtaa ggcaaccagg tatgccaagt gttttgggga cacacgtggt ggagagaaag aagaacatgg gttcgtggag gatgccatta ccagcaaggg ccaccagata gtggaattgc tccagccctg ggatccccac cagattcaat gtggccatc

300

360

420

480

540

600

660

720

780

840

900

949

<400> 3422 Met Ala Thr Leu Asn Leu Thr Ser 1 5 Val Gly Ile Pro Gly Leu Glu Gln 20 Phe Phe Thr 35 Ile Tyr Leu Val Ala 40 Tyr Leu Ile 50 Thr Val Asp His Ser 55 Leu Ser Met 65 Leu Ala Ser Ala Asp 70

Phe Asn 10 Pro Gly Ser Phe Ile 15 Leu Phe 25 His Ile Trp Ile Gly 30 Ile Pro Leu Ala Gly Asn Gly 45 Ile Leu Leu Leu His Glu Pro 60 Met Phe Phe Phe Leu Val Leu 75 Cys Thr Thr Cys Val 80

Page 3826

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Pro Lys Thr Leu Gly 85 Ile Phe Trp Leu Lys Ala Gln Lys Ile Thr Phe 90 95 Pro Gly Cys Leu Thr Gln Leu Phe Phe Leu His Phe Ser Phe Phe Leu 100 105 110 Asp Ser Ala Ile Leu Leu Gly Met Ala Phe Gly Arg Tyr Met Ala Ile 115 120 125 Cys Cys Pro Leu Arg Tyr Thr Ser Val Leu Thr Pro Arg Thr Ile Val 130 135 140 Lys Ile Met Val Gly Ile Val Gly Arg Ser Phe Gly Val Ile Leu Pro 145 150 155 160 Val Val Phe Leu Val Lys Arg Leu Pro Phe Cys Lys Ser Arg Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys Ala 180 185 190 Asp Ile Ser Ile Asn Ile Trp Tyr Gly Phe Ala Val Pro Val Met Thr 195 200 205 Ile Ile Ser Asp Leu Val Leu Ile Gly Ile Ser Tyr Ala Leu Ile Leu 210 215 220 His Ala Val Phe His Leu Pro Ser Arg Asp Ala His Gln Lys Ala Leu 225 230 235 240 Ser Thr Cys Gly Ser His Val Cys Val Ile Leu Ile Phe Tyr Thr Pro 245 250 255 Ala Ile Phe Ser Val Leu Thr His Arg Phe Gly His Asn Ile Ser Cys 260 265 270 Thr Phe His Ile Ile Phe Ala Asn Leu Tyr Val Ala Ile Pro Pro Ala 275 280 285

Page 3827

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Leu Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp Lys 290 295 300

Val Ile Leu Leu Leu Phe Pro Lys Gly Met Lys 305 310 315 <210> 3423 <211> 981 <212> DNA <213> Felis catus <400> 3423

atggcccttt catctgccag gagcacggct gccgtgaacg actctgacac tcgcacgaca 60 ggctgcctcc tcactggcat ccctgggctg gagcacctgc acatctggct ctccatcccc 120 ttctgcgcca tgtatgtagc cgccctggca ggcaatggca ttttaatttg tatcatcctc 180 tcacagccaa gcctgcacga gcccatgtac atattcctgt ccatgctggc cagtgcagat 240 atcttgctct ccacttccac gatgcccaaa acactggcca acttctggct aggttccagc 300 cacatttcct ttgatggctg cctcacccaa atgttcttca tccacttcct ctttgtggcc 360 gactctgcag tcctgctggc catggccttt gaccgctttg tggccatctg ctcccctctg 420 cgatatacca cagtcctcac gagcaccgtc attgggaaga tcgtcgctgc caccctgacc 480 cgcagcctca tcatcatgtt tccatccatc tttcttctca agcgcctgca ctattgccgg 540 atcaacatca ttgcacacac tttttgtgag cacatgggca tcgcccgtct gtcttgttct 600 gatatctcca tcaatgtctg gtacgggttg gcagctgccc tactctccac aggcctggac 660 atcatcctta tcgctgtttc ctacattcac atcctacgag ctgtcttccg cctcccttct 720 cgaaatgccc ggtccaaggc cctgagcaca tgtggctccc acgtctgtgt catcctactc 780 ttctacatcc ctgccctttt ctctgtcttt gcctacaggt tcggtgagag acgcatccca 840 cgctatgtcc atatcctcct ggccaacctc tatgtggtca tcccgcctat gcttaatccc 900 attatttatg gagcaaggac caagcagatt tgggaagggg ctaaacagat gttttcacat 960 cttgccaagg aatctaaata a 981

<210> 3424 <211> 326 <212> PRT

Page 3828

069269_0225_SL.TXT <213> Felis catus <400> 3424

Met Ala Leu Ser Ser Ala Arg Ser Thr Ala Ala Val Asn Asp Ser Asp 1 5 10 15 Thr Arg Thr Thr Gly Cys Leu Leu Thr Gly Ile Pro Gly Leu Glu His 20 25 30 Leu His Ile Trp Leu Ser Ile Pro Phe Cys Ala Met Tyr Val Ala Ala 35 40 45 Leu Ala Gly Asn Gly Ile Leu Ile Cys Ile Ile Leu Ser Gln Pro Ser 50 55 60 Leu His Glu Pro Met Tyr Ile Phe Leu Ser Met Leu Ala Ser Ala Asp 65 70 75 80 Ile Leu Leu Ser Thr Ser Thr Met Pro Lys Thr Leu Ala Asn Phe Trp 85 90 95 Leu Gly Ser Ser His Ile Ser Phe Asp Gly Cys Leu Thr Gln Met Phe 100 105 110 Phe Ile His Phe Leu Phe Val Ala Asp Ser Ala Val Leu Leu Ala Met 115 120 125 Ala Phe Asp Arg Phe Val Ala Ile Cys Ser Pro Leu Arg Tyr Thr Thr 130 135 140 Val Leu Thr Ser Thr Val Ile Gly Lys Ile Val Ala Ala Thr Leu Thr 145 150 155 160 Arg Ser Leu Ile Ile Met Phe Pro Ser Ile Phe Leu Leu Lys Arg Leu 165 170 175 His Tyr Cys Arg Ile Asn Ile Ile Ala His Thr Phe Cys Glu His Met 180 185 190 Gly Ile Ala Arg Leu Ser Cys Ser Asp Ile Ser Ile Asn Val Trp Tyr

Page 3829

195 069269_0225_SL.TXT 200 205 Gly Leu Ala Ala Ala Leu Leu Ser Thr Gly Leu Asp Ile Ile Leu Ile 210 215 220 Ala Val Ser Tyr Ile His Ile Leu Arg Ala Val Phe Arg Leu Pro Ser 225 230 235 240 Arg Asn Ala Arg Ser Lys Ala Leu Ser Thr Cys Gly Ser His Val Cys 245 250 255 Val Ile Leu Leu Phe Tyr Ile Pro Ala Leu Phe Ser Val Phe Ala Tyr 260 265 270 Arg Phe Gly Glu Arg Arg Ile Pro Arg Tyr Val His Ile Leu Leu Ala 275 280 285 Asn Leu Tyr Val Val Ile Pro Pro Met Leu Asn Pro Ile Ile Tyr Gly 290 295 300 Ala Arg Thr Lys Gln Ile Trp Glu Gly Ala Lys Gln Met Phe Ser His 305 310 315 320

Leu Ala Lys Glu Ser Lys 325 <210> 3425 <211> 953 <212> DNA <213> Felis catus <400> 3425

taaaccacac tgctgttagc catacaatct tccacttgct gggcatcccc gggctagagg 60 accagcatgt gtggatttcc atccccttct tcgtttccta tgtcatcgcc ctgcttggga 120 acagcctgct catctgcatt atcctcacaa agcagagcct ccatgaaccc atgtacctct 180 tcctctgcat gctggccgga gcagatgttg tcctctccac gtgcacagta cctcaggcct 240 tggccatctt ctggttccgt gctggggaga tctccctgga tcgctgcata actcagttct 300 tcatcatcca ctgcactttc atgtctgagt cggggatctt gctggtgatg gcgtttgacc 360

Page 3830

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actacattgc catatgctac ccactgagat acaccactat tcttacacgt gcactgattg 420 gaaaaattgg cgtgactata attctgaaaa gtttctgtac acttttcccc atagtatttc 480 ttttgaaaag attgactttc tgccaaaata atattgttcc acacaccttt tgtgaacaca 540 ttggcttggc caaatatgct tgtaatgaca ttcgtgtgaa catctggtat ggattttcca 600 tcctaatatt aacagtggtt ttagatgtgg tgctaatttt tgtttcctat gtgctgattc 660 tccgtgctgt cttccacatc ccttcccaag atgctcgcca caaagctctt aacacatgtg 720 gctcccatgt ctgcatcatt gtcctctttt acagccctgc gatcttcaca acccttactc 780 agcggtttgg acgccacatt cctcctcata cccacatctt gttggccaac atctgcatgc 840 ttgccccacc tatgctgaat cccatcattt atgggattaa gaccaagcaa atcagagagc 900 aggtggttca catgttgttt acaaagcaga aatcactttg gttgaagaac tga 953

<210> 3426 <211> 316 <212> PRT <213> Felis catus <400> 3426

Asn His 1 Thr Ala Val 5 Ser His Thr Ile Phe His 10 Leu Leu Gly Ile 15 Pro Gly Leu Glu Asp Gln His Val Trp Ile Ser Ile Pro Phe Phe Val Ser 20 25 30 Tyr Val Ile Ala Leu Leu Gly Asn Ser Leu Leu Ile Cys Ile Ile Leu 35 40 45 Thr Lys Gln Ser Leu His Glu Pro Met Tyr Leu Phe Leu Cys Met Leu 50 55 60 Ala Gly Ala Asp Val Val Leu Ser Thr Cys Thr Val Pro Gln Ala Leu 65 70 75 80 Ala Ile Phe Trp Phe Arg Ala Gly Glu Ile Ser Leu Asp Arg Cys Ile 85 90 95

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Thr Gln Phe Phe 100 Ile Ile His Cys Thr Phe Met Ser Glu Ser Gly Ile 105 110 Leu Leu Val Met Ala Phe Asp His Tyr Ile Ala Ile Cys Tyr Pro Leu 115 120 125 Arg Tyr Thr Thr Ile Leu Thr Arg Ala Leu Ile Gly Lys Ile Gly Val 130 135 140 Thr Ile Ile Leu Lys Ser Phe Cys Thr Leu Phe Pro Ile Val Phe Leu 145 150 155 160 Leu Lys Arg Leu Thr Phe Cys Gln Asn Asn Ile Val Pro His Thr Phe 165 170 175 Cys Glu His Ile Gly Leu Ala Lys Tyr Ala Cys Asn Asp Ile Arg Val 180 185 190 Asn Ile Trp Tyr Gly Phe Ser Ile Leu Ile Leu Thr Val Val Leu Asp 195 200 205 Val Val Leu Ile Phe Val Ser Tyr Val Leu Ile Leu Arg Ala Val Phe 210 215 220 His Ile Pro Ser Gln Asp Ala Arg His Lys Ala Leu Asn Thr Cys Gly 225 230 235 240 Ser His Val Cys Ile Ile Val Leu Phe Tyr Ser Pro Ala Ile Phe Thr 245 250 255 Thr Leu Thr Gln Arg Phe Gly Arg His Ile Pro Pro His Thr His Ile 260 265 270 Leu Leu Ala Asn Ile Cys Met Leu Ala Pro Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Gly Ile Lys Thr Lys Gln Ile Arg Glu Gln Val Val His Met 290 295 300

Page 3832

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Leu Phe Thr Lys Gln Lys Ser Leu Trp Leu Lys Asn 305 310 315 <210> 3427 <211> 942 <212> DNA <213> Felis catus <400> 3427 atgcataatt tgagctgcta caatcccagt tcctttctcc ttgtgggaat acctggcctg 60 gacaagttcc acatctggat tgggattccc ttttgtgtca tctatgtttt ggctattgtg 120 ggaaacttca tcctcctcta cctcattgca actgagcaca gcctccatga gcccatgttt 180 ttcttcctag ctatgctggc taccacggac ctcatcctgt ccactgccac agtgcccaaa 240 ctgctcagta acctctggct gggcttccag gaaataacct tctctggctg tctcacccag 300 atgttcttcc tccacttcag ctttgtagtg gactcagcca tcctgttggc catggcgttc 360 gatcgctatg tggccatctg cttccctttg aggtacacca ccatcctgac tcggcaggtg 420 atcatcaagc tgatggtgag cattgttgtg aggagcttct ctgtcatctt gccagatgtt 480 tttctgctga aacggttacc cttctgtggg acacgcatca taccgcacac atactgtgag 540 cacataggtg ttgctcggct ttcctctgct gacatctcca tcaacatctg gtatggattt 600 tctgtccctc tcatgactgt catctcagat gtgatcttta ttgctgtttc ctataccttc 660 atcctccatg ctgtctttca cctctcatcc cagggtgccc gccaaaaggc cctcagcacc 720 tgtggttccc atgtcagtgt catcctcatg ttttacacac ctgccttctt ctccatcctt 780 gcacatcgct ttgggcacag tgtccctcga aatgtgctca tcctatttgc caacctctat 840 gtggccatcc cccctgccct aaatcctgtg gtctatggag tgaagaccaa gcagatccag 900 gacaaatttg ttctcctctt ttctttgaag aggacacact ga 942 <210> 3428 <211> 313 <212> PRT <213> Felis catus <400> 3428

Met His Asn Leu Ser Cys Tyr Asn Pro Ser Ser Phe Leu Leu Val Gly 1 5 10 15

Page 3833

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Ile Pro Gly Leu 20 Asp Lys Phe His Ile Trp Ile Gly Ile Pro Phe Cys 25 30 Val Ile Tyr Val Leu Ala Ile Val Gly Asn Phe Ile Leu Leu Tyr Leu 35 40 45 Ile Ala Thr Glu His Ser Leu His Glu Pro Met Phe Phe Phe Leu Ala 50 55 60 Met Leu Ala Thr Thr Asp Leu Ile Leu Ser Thr Ala Thr Val Pro Lys 65 70 75 80 Leu Leu Ser Asn Leu Trp Leu Gly Phe Gln Glu Ile Thr Phe Ser Gly 85 90 95 Cys Leu Thr Gln Met Phe Phe Leu His Phe Ser Phe Val Val Asp Ser 100 105 110 Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Phe 115 120 125 Pro Leu Arg Tyr Thr Thr Ile Leu Thr Arg Gln Val Ile Ile Lys Leu 130 135 140 Met Val Ser Ile Val Val Arg Ser Phe Ser Val Ile Leu Pro Asp Val 145 150 155 160 Phe Leu Leu Lys Arg Leu Pro Phe Cys Gly Thr Arg Ile Ile Pro His 165 170 175 Thr Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ser Ser Ala Asp Ile 180 185 190 Ser Ile Asn Ile Trp Tyr Gly Phe Ser Val Pro Leu Met Thr Val Ile 195 200 205 Ser Asp Val Ile Phe Ile Ala Val Ser Tyr Thr Phe Ile Leu His Ala 210 215 220

Page 3834

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Val Phe 225 His Leu Ser Ser 230 Gln Gly Ala Arg Gln Lys Ala Leu Ser Thr 235 240 Cys Gly Ser His Val Ser Val Ile Leu Met Phe Tyr Thr Pro Ala Phe 245 250 255 Phe Ser Ile Leu Ala His Arg Phe Gly His Ser Val Pro Arg Asn Val 260 265 270 Leu Ile Leu Phe Ala Asn Leu Tyr Val Ala Ile Pro Pro Ala Leu Asn 275 280 285 Pro Val Val Tyr Gly Val Lys Thr Lys Gln Ile Gln Asp Lys Phe Val 290 295 300 Leu Leu Phe Ser Leu Lys Arg Thr His 305 310

<210> 3429 <211> 937 <212> DNA <213> Felis catus <400> 3429

ccacattcaa cttgagcagc ttcaattcag gccctttcat cctactggga atcccagggc 60 tggaggagtt ccatgtctgg atcgggattc cttttttcat tatctacctt gtggcccttg 120 caggcaacag tgtccttctc taccttattt ccatggaacg cagccttcat cagcccatgt 180 tctttttcct ctccatgctg gctgctacag atctcatcct atctaataca tgtgtaccca 240 aaacattcag catcttctgg ctaggtcctc aggaaatcac cttttctgga tgccttactc 300 aaatgttctt tctccactat agctttgcca tggattctgc catcctgtta gccatggcat 360 ttgatcgcta tgttgctgtt tgcttccccc taagatatac cactattctt acccgtcaga 420 ttattactaa aattgtaatg gctattgtta gcaggagctt ttgcatcatc ttcccatgtg 480 tgttcctatt aaaacgacta cctttttgcc gaacactcat catcccccac acgtactgtg 540 agcacatagg catagcccag cttgcctgtg cggacatctc catcaacatc tggtatggct 600 ttgctgtgcc tgtaatgact gttacatcag acctgatcct cattggcatc tcctacactc 660

Page 3835

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tcatccttcg tgccatcttt aatcttccat cccgagatgc ccgccagaaa gccctcaaca 720 cctgtggttc ccatgtttgt gtcattctta tattctacac accagcaatg ttctctgtcc 780 tcacccaccg ttttggtcac aatattcctc actccttcca catactgact gccaacctct 840 acgtggccat ccctcctgca ctcaatccaa tcatctatgg ggtgaagacc aagcagattc 900 gggaaaaaat catcctaccc ttcttcccta aagggaa 937

<210> 3430 <211> 312 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (312)..(312) <223> Any amino acid

<400> 3430 Ser Phe Asn Ser Gly Pro Phe Ile Leu Leu Gly Thr Phe 1 Asn Leu Ser 5 10 15 Ile Pro Gly Leu Glu Glu Phe His Val Trp Ile Gly Ile Pro Phe Phe 20 25 30 Ile Ile Tyr Leu Val Ala Leu Ala Gly Asn Ser Val Leu Leu Tyr Leu 35 40 45 Ile Ser Met Glu Arg Ser Leu His Gln Pro Met Phe Phe Phe Leu Ser 50 55 60 Met Leu Ala Ala Thr Asp Leu Ile Leu Ser Asn Thr Cys Val Pro Lys 65 70 75 80 Thr Phe Ser Ile Phe Trp Leu Gly Pro Gln Glu Ile Thr Phe Ser Gly 85 90 95 Cys Leu Thr Gln Met Phe Phe Leu His Tyr Ser Phe Ala Met Asp Ser 100 105 110

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Ala Ile Leu 115 Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Val Cys Phe 120 125 Pro Leu Arg Tyr Thr Thr Ile Leu Thr Arg Gln Ile Ile Thr Lys Ile 130 135 140 Val Met Ala Ile Val Ser Arg Ser Phe Cys Ile Ile Phe Pro Cys Val 145 150 155 160 Phe Leu Leu Lys Arg Leu Pro Phe Cys Arg Thr Leu Ile Ile Pro His 165 170 175 Thr Tyr Cys Glu His Ile Gly Ile Ala Gln Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Ile Trp Tyr Gly Phe Ala Val Pro Val Met Thr Val Thr 195 200 205 Ser Asp Leu Ile Leu Ile Gly Ile Ser Tyr Thr Leu Ile Leu Arg Ala 210 215 220 Ile Phe Asn Leu Pro Ser Arg Asp Ala Arg Gln Lys Ala Leu Asn Thr 225 230 235 240 Cys Gly Ser His Val Cys Val Ile Leu Ile Phe Tyr Thr Pro Ala Met 245 250 255 Phe Ser Val Leu Thr His Arg Phe Gly His Asn Ile Pro His Ser Phe 260 265 270 His Ile Leu Thr Ala Asn Leu Tyr Val Ala Ile Pro Pro Ala Leu Asn 275 280 285 Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Lys Ile Ile 290 295 300 Leu Pro Phe Phe Pro Lys Gly Xaa 305 310

Page 3837

069269_0225_SL.TXT <210> 3431 <211> 951 <212> DNA <213> Felis catus <400> 3431

atgctgtcca catctgtcat caataacact gcctttcatc cttccacatt tattctactt 60 ggaatccctg gaatgcaaga tcagcatgtg tgggctgcca tccccttctg ctccatgtat 120 atccttgctc tggttggcaa tggcaccatc ctctacatcg tcatgacaaa tagaactcta 180 catgagccaa tgtacctctt cctgtgcctg ctttctatca ctgacctggt tctctgttcg 240 accacattgc ccaaaatgtt aacaatattt tggtttaggt cccacataat ttcctaccat 300 ggctgcctca cccagatgtt ttttgttcac actatttttg ccacagagtc ggctgttcta 360 ctggccatgg cttttgaccg ctatgtggct atctgccatc cacttcatta tacatccatc 420 ctcaatgcca cagtgattgg gaagattggt ctggcatgtg tggtccgtgg ccttatcttt 480 gttttcccct ttgtcatcct catcaaacgt ttacccttct gtggacacca catcatcccc 540 cacacttact gtgagcacat gggcattgcc aagctcgcct gtgccagcat caagcccaac 600 accatttatg gactcactgt ggcactttca gtcactggca tggatgtggt cctcatcacc 660 acctcctacg gcttgatcct gcgggctgtg ctgcgcttgc cctccaagga tgcccaattc 720 cgagcattta gcacttgtgg agcccatatt tgtgtgattc tggttttcta tgtacctgcc 780 ttcttttcat ttttcaccca ccgctttggc caccaagtac ctcctcatgt ccacattgta 840 cttgcaaatc tctatctcct cgtgccccct gttcttaacc ccctggtcta tggcatcaat 900 accaaacaaa tccgcctaag aatatttggc ttttttatgg gaaggaggta g 951

<210> 3432 <211> 316 <212> PRT <213> Felis catus <400> 3432

Met Leu Ser Thr Ser Val Ile Asn Asn Thr Ala Phe His Pro Ser Thr 1 5 10 15 Phe Ile Leu Leu Gly Ile Pro Gly Met Gln Asp Gln His Val Trp Ala

20 25 30

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Ala Ile Pro 35 Phe Cys Ser Met Tyr Ile Leu Ala Leu Val Gly Asn Gly 40 45 Thr Ile Leu Tyr Ile Val Met Thr Asn Arg Thr Leu His Glu Pro Met 50 55 60 Tyr Leu Phe Leu Cys Leu Leu Ser Ile Thr Asp Leu Val Leu Cys Ser 65 70 75 80 Thr Thr Leu Pro Lys Met Leu Thr Ile Phe Trp Phe Arg Ser His Ile 85 90 95 Ile Ser Tyr His Gly Cys Leu Thr Gln Met Phe Phe Val His Thr Ile 100 105 110 Phe Ala Thr Glu Ser Ala Val Leu Leu Ala Met Ala Phe Asp Arg Tyr 115 120 125 Val Ala Ile Cys His Pro Leu His Tyr Thr Ser Ile Leu Asn Ala Thr 130 135 140 Val Ile Gly Lys Ile Gly Leu Ala Cys Val Val Arg Gly Leu Ile Phe 145 150 155 160 Val Phe Pro Phe Val Ile Leu Ile Lys Arg Leu Pro Phe Cys Gly His 165 170 175 His Ile Ile Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Lys Leu 180 185 190 Ala Cys Ala Ser Ile Lys Pro Asn Thr Ile Tyr Gly Leu Thr Val Ala 195 200 205 Leu Ser Val Thr Gly Met Asp Val Val Leu Ile Thr Thr Ser Tyr Gly 210 215 220 Leu Ile Leu Arg Ala Val Leu Arg Leu Pro Ser Lys Asp Ala Gln Phe 225 230 235 240

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Arg Ala Phe Ser Thr Cys Gly Ala His Ile Cys Val Ile Leu Val Phe 245 250 255 Tyr Val Pro Ala Phe Phe Ser Phe Phe Thr His Arg Phe Gly His Gln 260 265 270 Val Pro Pro His Val His Ile Val Leu Ala Asn Leu Tyr Leu Leu Val 275 280 285 Pro Pro Val Leu Asn Pro Leu Val Tyr Gly Ile Asn Thr Lys Gln Ile 290 295 300 Arg Leu Arg Ile Phe Gly Phe Phe Met Gly Arg Arg 305 310 315

<210> 3433 <211> 978 <212> DNA <213> Felis catus <400> 3433

atgaccgttt gcaatgcgtc cctgggtcac ccacctttct tcattctcca aggcattcct 60 gggatggagg acaagcacag atggatctct gtccccttct cttccatgta cttcatcacc 120 atccttggga actgcaccat catcttcacc atctgcaccg agcgctccct gcacaaaccc 180 atgttccttc tcctctgcat gttggccctc acagacctgg gcatgtccac taccaccatt 240 cctaaggtgc tgtgcatctt ctggtttggc cagagtgaga tcagctatgt gggctgcctg 300 gtccaaatgt tcttcatcca cttcatatct gtgttgcagt cagccatcct gatgaccatg 360 gcctttgacc gctatgtagc catctgtgaa cctctgcgtt atgccaccat cctttccaat 420 agtcgcattg ggctcattgg cctggtgagt ttagtgagag ccattctttt cattctgccc 480 atgcctgtcc tcctccagaa gatgcccttt catgtaaatc acgtcatccc caccacctac 540 tgtgagcaca tggctgtggt gaagatggtg tgtgtggaca ccacagtcaa caggatatat 600 ggtctggtgg tggccttgtt ggttatcggg ctggacatct cagctattgc ttcatcgtat 660 gtgcttatca tccgggctgt actgcgactg tcttctaagg aagcccacca caaagcagtc 720 aacacctgca ccacacacat ttgtgtcatg cttatctcat acactccctc gctgttctct 780

Page 3840

069269_0225_SL.TXT tttctcactc accgctttgg taggggaatt gcaccccatg tgcacaccat tcttgggaac ctctacttcc ttgttcctcc aatgctcaat cctattattt atgcagtgaa aaccaaagag tttcgggaca aattgaccaa atacgggtgc tggaagaagg accctgtaac cataacccat ggtcagaagc ctgtctga

840

900

960

978 <210> 3434 <211> 325 <212> PRT <213> Felis catus <400> 3434

Met Thr Val Cys 1 Asn 5 Ala Ser Leu Gly His Pro Pro Phe Phe Ile Leu 10 15 Gln Gly Ile Pro Gly Met Glu Asp Lys His Arg Trp Ile Ser Val Pro 20 25 30 Phe Ser Ser Met Tyr Phe Ile Thr Ile Leu Gly Asn Cys Thr Ile Ile 35 40 45 Phe Thr Ile Cys Thr Glu Arg Ser Leu His Lys Pro Met Phe Leu Leu 50 55 60 Leu Cys Met Leu Ala Leu Thr Asp Leu Gly Met Ser Thr Thr Thr Ile 65 70 75 80 Pro Lys Val Leu Cys Ile Phe Trp Phe Gly Gln Ser Glu Ile Ser Tyr 85 90 95 Val Gly Cys Leu Val Gln Met Phe Phe Ile His Phe Ile Ser Val Leu 100 105 110 Gln Ser Ala Ile Leu Met Thr Met Ala Phe Asp Arg Tyr Val Ala Ile 115 120 125 Cys Glu Pro Leu Arg Tyr Ala Thr Ile Leu Ser Asn Ser Arg Ile Gly 130 135 140

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Leu 145 Ile Gly Leu Val Ser 150 Leu Val Arg Ala Ile Leu Phe Ile Leu Pro 155 160 Met Pro Val Leu Leu Gln Lys Met Pro Phe His Val Asn His Val Ile 165 170 175 Pro Thr Thr Tyr Cys Glu His Met Ala Val Val Lys Met Val Cys Val 180 185 190 Asp Thr Thr Val Asn Arg Ile Tyr Gly Leu Val Val Ala Leu Leu Val 195 200 205 Ile Gly Leu Asp Ile Ser Ala Ile Ala Ser Ser Tyr Val Leu Ile Ile 210 215 220 Arg Ala Val Leu Arg Leu Ser Ser Lys Glu Ala His His Lys Ala Val 225 230 235 240 Asn Thr Cys Thr Thr His Ile Cys Val Met Leu Ile Ser Tyr Thr Pro 245 250 255 Ser Leu Phe Ser Phe Leu Thr His Arg Phe Gly Arg Gly Ile Ala Pro 260 265 270 His Val His Thr Ile Leu Gly Asn Leu Tyr Phe Leu Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Ile Tyr Ala Val Lys Thr Lys Glu Phe Arg Asp Lys 290 295 300 Leu Thr Lys Tyr Gly Cys Trp Lys Lys Asp Pro Val Thr Ile Thr His 305 310 315 320 Gly Gln Lys Pro Val

<210> 3435 <211> 935 <212> DNA <213> Felis catus

325

Page 3842

069269_0225_SL.TXT <400> 3435

ctatgcaggt cctctgcaaa ggcatttggt caccttgtgc catatttcct tcatttttct 60 accatagatg atggggttga gcactgaggg tagaagaagg tagagattgg caaggagaac 120 acgagcatga ggtgggatac tgtgaccaat gcggtgcatg agagacgaaa agagtgcagg 180 aacataagtg acaagaatga caaagaggtg agctgaacag gtgttgagag ctttataggt 240 agcatcttga gagttgagac ataccagagc ctgaagaatg aagccataag agaagccaat 300 gagcagcaga tcaagtccca ccactagcag aatcacaaag agcccataga tatggttagg 360 tctggtatgg tcacaggcca ttttcaccaa agccatgtgg tcacagtagg tatgaggaat 420 gaccatgtgg cagaatgtca acctttgaag tagaagtagc atgggtagga taagaatcac 480 acccttgcca gagccatcag tcccaggcat ccaactaagg aatggctcag aattgtgttg 540 tagcataacg gctcacatac agccacaaag cggtcaaagg ccattgcaac aagtaaggct 600 gatcatacca cagatgttct atggatgaaa aacatctggg tgaaacaggc attggcagct 660 atatccccat cattgaacca gaagaggcaa aggaacttgg gcaatagagc cagagtagat 720 atgaggtcag ccaccatcag caaggccagg agcaggtaca ttgggatgtg aaatgtgggc 780 tctgtggcca ccagaaagag aatagcacca ttgacaatga ggacagccaa gaacatggag 840 gagaaaggaa taaataacca caagtgctgt gactctaagc ctggtatgcc catcaaagtg 900 aagttcagga tgctggaatg gttgaagatt agcat 935

<210> 3436 <211> 181 <212> PRT <213> Felis catus <400> 3436

Met 1 Leu Gln His Asn 5 Ser Glu Pro Phe Leu Ser Trp Met Pro Gly Thr 10 15 Asp Gly Ser Gly Lys Gly Val Ile Leu Ile Leu Pro Met Leu Leu Leu 20 25 30 Leu Gln Arg Leu Thr Phe Cys His Met Val Ile Pro His Thr Tyr Cys 35 40 45

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Asp His Met 50 Ala Leu Val Lys Met Ala Cys Asp His Thr Arg Pro Asn 55 60 His Ile Tyr Gly Leu Phe Val Ile Leu Leu Val Val Gly Leu Asp Leu 65 70 75 80 Leu Leu Ile Gly Phe Ser Tyr Gly Phe Ile Leu Gln Ala Leu Val Cys 85 90 95 Leu Asn Ser Gln Asp Ala Thr Tyr Lys Ala Leu Asn Thr Cys Ser Ala 100 105 110 His Leu Phe Val Ile Leu Val Thr Tyr Val Pro Ala Leu Phe Ser Ser 115 120 125 Leu Met His Arg Ile Gly His Ser Ile Pro Pro His Ala Arg Val Leu 130 135 140 Leu Ala Asn Leu Tyr Leu Leu Leu Pro Ser Val Leu Asn Pro Ile Ile 145 150 155 160 Tyr Gly Arg Lys Met Lys Glu Ile Trp His Lys Val Thr Lys Cys Leu 165 170 175 Cys Arg Gly Pro Ala

180 <210> 3437 <211> 962 <212> DNA <213> Felis catus <400> 3437 agtctcctaa tgacactaac ctggaccctt ctgttttctt cctcttgggc atcccaggtc tggaacagtt ccacctctgg ctctcactcc ctgtgtgctg cctgagcaca gccacagttg tgggcaacat caccatcttg gttgttgttg ccactgagcc agccctgcac aagcctgtgt acctgttcct gtgcatgctc tcaaccattg acttggctgc ctccttctcc acagttccca aactactggc catcctctgg tgtgcagctg gacacatctc agcctctgct tgccttgcac

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Page 3844

069269_0225_SL.TXT agatgttctt cattcatgct ttctgcatga ttgatcgcta tgtggccatt tgtcacccac tcattgcccg cattggagtg gtagctatgg ccttcctcat tgggcgtttg agcttctgcc aacacatggc tgttgtgaag ctagcatgtg tgacagcagc acttttggtc attggggttg ttattgcaag atctgtcctt cgtctctcat cttgtggttc ccatgtctgt gtcatcctaa ttacccatcg ctttggccac cacgttccac atctactctt cccacctgct cttaacccta gggaaaaggt tgtcagagtg tttcaaaggg ga <210> 3438 <211> 319 <212> PRT <213> Felis catus tggagtccac tgtgctgctg gccatggcct tccgctatgc cactattctc actgacacca tgcggggctc catgctcatg ctcccatgtc aaagccatgt cattccacat acatactgtg gagacaccag gcctaaccgt gtgtatgggc acttgttctg cattggtctc tcctatgtct cccatgaagc tcggtccaag gccctgggga tctcttatac accagccctc ttctccttct tccatattca cattcttttg gccaatgtct tagtatatgg agttaagacc aaagaaatcc gtcagggaat tggggtcaag gtacctgagt

360

420

480

540

600

660

720

780

840

900

960

962

<400> 3438 Ser Pro Asn Asp Thr Asn Leu Asp 1 5 Ile Pro Gly Leu Glu Gln Phe His 20 Cys Leu Ser Thr Ala Thr Val Val 35 40 Val Ala Thr Glu Pro Ala Leu His 50 55 Met Leu Ser Thr Ile Asp Leu Ala 65 70

Pro Ser 10 Val Phe Phe Leu Leu 15 Gly Leu 25 Trp Leu Ser Leu Pro 30 Val Cys Gly Asn Ile Thr Ile 45 Leu Val Val Lys Pro Val Tyr 60 Leu Phe Leu Cys Ala Ser Phe 75 Ser Thr Val Pro Lys 80

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Leu Leu Ala Ile Leu 85 Trp Cys Ala Ala Gly His Ile Ser Ala Ser Ala 90 95 Cys Leu Ala Gln Met Phe Phe Ile His Ala Phe Cys Met Met Glu Ser 100 105 110 Thr Val Leu Leu Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Ala Thr Ile Leu Thr Asp Thr Ile Ile Ala Arg Ile 130 135 140 Gly Val Val Ala Met Val Arg Gly Ser Met Leu Met Leu Pro Cys Pro 145 150 155 160 Phe Leu Ile Gly Arg Leu Ser Phe Cys Gln Ser His Val Ile Pro His 165 170 175 Thr Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys Gly Asp Thr 180 185 190 Arg Pro Asn Arg Val Tyr Gly Leu Thr Ala Ala Leu Leu Val Ile Gly 195 200 205 Val Asp Leu Phe Cys Ile Gly Leu Ser Tyr Val Phe Ile Ala Arg Ser 210 215 220 Val Leu Arg Leu Ser Ser His Glu Ala Arg Ser Lys Ala Leu Gly Thr 225 230 235 240 Cys Gly Ser His Val Cys Val Ile Leu Ile Ser Tyr Thr Pro Ala Leu 245 250 255 Phe Ser Phe Phe Thr His Arg Phe Gly His His Val Pro Leu His Ile 260 265 270 His Ile Leu Leu Ala Asn Val Tyr Leu Leu Phe Pro Pro Ala Leu Asn 275 280 285

Page 3846

069269_0225_S L.TXT Pro Ile Val Tyr Gly Val Lys Thr Lys Glu Ile Arg Glu Lys Val Val 290 295 300 Arg Val Phe Gln Arg Gly Gln Gly Ile Gly Val Lys Val Pro Glu 305 310 315

<210> 3439 <211> 969 <212> DNA <213> Felis catus <400> 3439

atgatgctaa tgttaaacca aacagacctg accccagcct cattcattct taatgggatc 60 ccaggactgg aggacatgca catgtggatt tctttcccat tctgctccat gtatgctgtg 120 gcaatggtag ggaattgtgg gctcctctac ctcatccact tagaggactc cctgcacagg 180 cccatgtatt actttttagc catgctttcc ctaactgacc ttttcatatg ctctagtaca 240 atccctaaag ccctcagcat attctggttc catttcaagg aaatcagctt cgatggatgt 300 ctggtccaaa tgttctttgt ccacaccttc acagggatgg agtctggggt gctcatgctt 360 atggctctgg accgttatgt ggccatctgc taccctctgc actattcaac tatcctcacc 420 aatcctgtca ttgcaaaggt tgggcttgct actttcctga gaggggtgtt cctcatcatt 480 cccttcactt tccttaccaa gcgcctgccc tactgcagag ggaatataat tcctcacacc 540 tactgtgacc acatgtctgt agctaagtta tcctgtggaa atatcaaggt caatgtcatc 600 tatggtctga tggttgccct cctgattggg ggctttgaca tcttgtgcat cacaatctcc 660 tacaccatga tcctccgggc agtggttagc ctctcttcag cagatgctcg gcagaaggct 720 ttcagcacct gcactgccca catctgtgcc attgttttct cctacagtcc agccttcttc 780 tccttctttt cccaccgctt tgggggccac acaattcctc catcttgtca tatcattgtg 840 gccaatatct atctgctttt gcctcccacg atgaatcccg ttgtctatgg ggtgaaaacc 900 aagcagatac gagactgtgt catcaggatc ctttcaggtt ctaagaacct caaatcccac 960

agcatatga 969 <210> 3440 <211> 322 <212> PRT

Page 3847

069269_0225_SL.TXT <213> Felis catus <400> 3440

Met 1 Met Leu Met Leu Asn Gln Thr Asp Leu Thr Pro Ala Ser Phe Ile 5 10 15 Leu Asn Gly Ile Pro Gly Leu Glu Asp Met His Met Trp Ile Ser Phe 20 25 30 Pro Phe Cys Ser Met Tyr Ala Val Ala Met Val Gly Asn Cys Gly Leu 35 40 45 Leu Tyr Leu Ile His Leu Glu Asp Ser Leu His Arg Pro Met Tyr Tyr 50 55 60 Phe Leu Ala Met Leu Ser Leu Thr Asp Leu Phe Ile Cys Ser Ser Thr 65 70 75 80 Ile Pro Lys Ala Leu Ser Ile Phe Trp Phe His Phe Lys Glu Ile Ser 85 90 95 Phe Asp Gly Cys Leu Val Gln Met Phe Phe Val His Thr Phe Thr Gly 100 105 110 Met Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala 115 120 125 Ile Cys Tyr Pro Leu His Tyr Ser Thr Ile Leu Thr Asn Pro Val Ile 130 135 140 Ala Lys Val Gly Leu Ala Thr Phe Leu Arg Gly Val Phe Leu Ile Ile 145 150 155 160 Pro Phe Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Ile 165 170 175 Ile Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Leu Ser Cys 180 185 190 Gly Asn Ile Lys Val Asn Val Ile Tyr Gly Leu Met Val Ala Leu Leu

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195 200 205 Ile Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile 210 215 220 Leu Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala 225 230 235 240 Phe Ser Thr Cys Thr Ala His Ile Cys Ala Ile Val Phe Ser Tyr Ser 245 250 255 Pro Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly Gly His Thr Ile 260 265 270 Pro Pro Ser Cys His Ile Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro 275 280 285 Pro Thr Met Asn Pro Val Val Tyr Gly Val Lys Thr Lys Gln Ile Arg 290 295 300 Asp Cys Val Ile Arg Ile Leu Ser Gly Ser Lys Asn Leu Lys Ser His 305 310 315 320

Ser Ile <210> 3441 <211> 969 <212> DNA <213> Felis catus <400> 3441 atgtctgcat ctctgaaagg ctctaatagc tccaagttcc aggtgtctga gttcatcttg atgggactcc caggcattca cagctggcaa cactggctct ccttaccatt ggcaatactc tacctctcag caattggtgc taatatcctc atcctcgtca ccatctgcca ggaccctgct cttcagcagc ccatgtactc tttcctaggc atcctctctg tggtggacat gggcctggcc accaccatca tgcccaagat cttggccatc ttctggtttg atgcgaaggt catcagcctt cctgagtgtt ttgctcagat ctatgccatt cactgctttg tgggcatgga gtctggtatc

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069269_0225_SL.TXT

ttcctctgca tggcttttga tagatacata gctatttgtc accctcttcg ctacccatca 420 attgtcacca aggcctttat cttaagagct actgtgttca tggtactaag aaatggcttg 480 tttgtcattc cagtgccagt gctagcagcc cagcgtaatt attgttccag gaacgagatc 540 gagcactgcc tgtgctctaa ccttggggtc accagcctgg cttgtgatga caggaggcca 600 aacagcatct gccaattggt tctagcatgg cttgtaatgg ggagtgacct aggtcttata 660 atattgtcat acattttgat tctgcgctct gtacttaaac tgaattctgc tgaagctgcc 720 tccaaagctc tgagcacttg tagctcccat ctcatcctta ttctattctt ctacactgtt 780 gttgtagtga tttcagtaac tcatctggca gaaactaagg tccctttggt tccagttcta 840 ctcaatgtgc tgcacaacat catcccccct tccctcaacc ctatggttta tgcacttagg 900 actaaagaac ttagggcagg cttccaaaag gtgttttgtt tgagcttaga aaagaaaaca 960

aggcaccag 969 <210> 3442 <211> 323 <212> PRT <213> Felis catus

<400> 3442 Leu Lys 5 Gly Ser Asn Ser Ser Lys Phe Gln Val Ser Met Ser 1 Ala Ser 10 15 Glu Phe Ile Leu Met Gly Leu Pro Gly Ile His Ser Trp Gln His Trp 20 25 30 Leu Ser Leu Pro Leu Ala Ile Leu Tyr Leu Ser Ala Ile Gly Ala Asn 35 40 45 Ile Leu Ile Leu Val Thr Ile Cys Gln Asp Pro Ala Leu Gln Gln Pro 50 55 60 Met Tyr Ser Phe Leu Gly Ile Leu Ser Val Val Asp Met Gly Leu Ala 65 70 75 80 Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Phe Trp Phe Asp Ala Lys 85 90 95

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Val Ile Ser Leu 100 Pro Glu Cys Phe Ala Gln Ile Tyr Ala Ile His Cys 105 110 Phe Val Gly Met Glu Ser Gly Ile Phe Leu Cys Met Ala Phe Asp Arg 115 120 125 Tyr Ile Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Val Thr Lys 130 135 140 Ala Phe Ile Leu Arg Ala Thr Val Phe Met Val Leu Arg Asn Gly Leu 145 150 155 160 Phe Val Ile Pro Val Pro Val Leu Ala Ala Gln Arg Asn Tyr Cys Ser 165 170 175 Arg Asn Glu Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Thr Ser 180 185 190 Leu Ala Cys Asp Asp Arg Arg Pro Asn Ser Ile Cys Gln Leu Val Leu 195 200 205 Ala Trp Leu Val Met Gly Ser Asp Leu Gly Leu Ile Ile Leu Ser Tyr 210 215 220 Ile Leu Ile Leu Arg Ser Val Leu Lys Leu Asn Ser Ala Glu Ala Ala 225 230 235 240 Ser Lys Ala Leu Ser Thr Cys Ser Ser His Leu Ile Leu Ile Leu Phe 245 250 255 Phe Tyr Thr Val Val Val Val Ile Ser Val Thr His Leu Ala Glu Thr 260 265 270 Lys Val Pro Leu Val Pro Val Leu Leu Asn Val Leu His Asn Ile Ile 275 280 285 Pro Pro Ser Leu Asn Pro Met Val Tyr Ala Leu Arg Thr Lys Glu Leu 290 295 300

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Arg Ala Gly Phe Gln Lys Val Phe Cys Leu Ser Leu Glu Lys Lys Thr 305 310 315 320

Arg His Gln <210> 3443 <211> 966 <212> DNA <213> Felis catus <400> 3443

atgctaatgc tgaataaaac aaactggact ccagcctcat tcattcttaa tggagtccca 60 ggactggagg acatgcacat gtggatttct ttcccattct gctccatgta tgctgtggca 120 atggtaggga attgtgggct tctctacctc atccacttag aggactccct gcacaggccc 180 atgtattact ttttagctat gctttcccta actgatattg tcatgtgctc tagtacaatc 240 cctaaagctc tcagcatctt ctggtgtcat ctcaaagaaa ttggctttgg tgaatgtctg 300 gtacagatgt tctttgtcca caccttcaca gggatggagt ctggggtgct catgcttatg 360 gccctggacc gttatgtggc catctgttac cctctgcgct attcaactat cctcaccaat 420 cctgtcattg caaaggttgg gcttgctact ttcctgagag gggtgttcct catcattccc 480 ttcactttcc ttaccaagcg cctgccctac tgcagaggga atataattcc tcacacctac 540 tgtgaccaca tgtctgtagc caagttatcc tgtggaaata tcaaggccaa tgtcatctat 600 ggtctgatgg ttgccctcct gattgggggc tttgacattt tgtgcatcac agtctcctac 660 accatgatcc tccgggcagt ggtgagcctc tcctcagcag atgctcggca gaaggctttc 720 agcacctgca ctgcccacat ctgtgccatc gttttctcct acagtccagc cttcttctcc 780 ttcttttccc accgctttgg gggccacaca atccctccat cttgccacat cattgtggcc 840 aatatttatc tgctcctgcc tcccactatg aaccctattg tctatggagt gaaaaccaag 900 cagatacgcg actgtgtcat aaggatcttt tcaggttcta aggacatcaa atcccacagc 960

atataa 966 <210> 3444

Page 3852

069269_0225_SL.TXT <211> 321 <212> PRT <213> Felis catus

<400> 3444 Lys Thr Asn Trp Thr Pro Ala Ser Phe Ile Leu Met 1 Leu Met Leu Asn 5 10 15 Asn Gly Val Pro Gly Leu Glu Asp Met His Met Trp Ile Ser Phe Pro 20 25 30 Phe Cys Ser Met Tyr Ala Val Ala Met Val Gly Asn Cys Gly Leu Leu 35 40 45 Tyr Leu Ile His Leu Glu Asp Ser Leu His Arg Pro Met Tyr Tyr Phe 50 55 60 Leu Ala Met Leu Ser Leu Thr Asp Ile Val Met Cys Ser Ser Thr Ile 65 70 75 80 Pro Lys Ala Leu Ser Ile Phe Trp Cys His Leu Lys Glu Ile Gly Phe 85 90 95 Gly Glu Cys Leu Val Gln Met Phe Phe Val His Thr Phe Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn Pro Val Ile Ala 130 135 140 Lys Val Gly Leu Ala Thr Phe Leu Arg Gly Val Phe Leu Ile Ile Pro 145 150 155 160 Phe Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Arg Gly Asn Ile Ile 165 170 175 Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys Leu Ser Cys Gly 180 185 190

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Asn Ile Lys 195 Ala Asn Val Ile Tyr Gly Leu Met Val Ala Leu Leu Ile 200 205 Gly Gly Phe Asp Ile Leu Cys Ile Thr Val Ser Tyr Thr Met Ile Leu 210 215 220 Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe 225 230 235 240 Ser Thr Cys Thr Ala His Ile Cys Ala Ile Val Phe Ser Tyr Ser Pro 245 250 255 Ala Phe Phe Ser Phe Phe Ser His Arg Phe Gly Gly His Thr Ile Pro 260 265 270 Pro Ser Cys His Ile Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro Pro 275 280 285 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300 Cys Val Ile Arg Ile Phe Ser Gly Ser Lys Asp Ile Lys Ser His Ser 305 310 315 320

Ile <210> 3445 <211> 966 <212> DNA <213> Felis <400> 3445 atgataattc ggactggagg atggtaggga atgtattatt cctaaagctc catus tgaaccaaac acatgcacat attgtgggct ttttggcaat tcagcatctt agatgtgacc gtggatttcc cctctacctc gctttccctt ctggtgtcat ccagcctcat ttcccattct atctactatg actgaccttg ctcaaggaaa tcattcttaa gctccatgta aggactccct tcatgtgctc ttagatttga tgggatccca tgctgtggca gcatagatcc tagtacaatc agaatgccta

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Page 3854

069269_0225_SL.TXT gtccagatgt tcttcatcca taccttcaca gggatggagt ctggggtgct catgcttatg gccctggatc gctacgtggc catctgttac cctctgcgct actcaactat cctcaccaat cctgtcattg caaaggttgg gcttgctact ttcctgagag cggtgttcct catcattccc ttgattttcc tcaccaagag actaccctat tgcaagggta atatcataca ccatacctat tgtgaccagc tatcggtagc aaagttatcc tgtggaaata tcaaggccaa tgttatatat ggtctggtgg ctgccttcct gattgggggc tttgacatcc tgtgcatcac agtctcctac accatgatcc tccgggcagt ggtgagcctg tcctcagcag atgctcggca gaaggccttc agcacctgca ctgcccacat ctgtgccatc gttttctcct acagtccagc cttcttctgc ttctttttta atcgttttgg gagccacaca attcctccat cttgccacat cattgtggcc aatatttatc tgctcctgcc tcccactatg aaccctattg tctatggagt gaaaaccaag cagatacgag actgtgtcat aaggatcttt tcaggttcga agaaaatcaa atcctatagc acatag <210> 3446 <211> 321 <212> PRT <213> Felis catus <400> 3446

360

420

480

540

600

660

720

780

840

900

960

966

Met Ile Ile Leu Asn Gln Thr Asp Val Thr Pro Ala Ser Phe Ile Leu 1 5 10 15 Asn Gly Ile Pro Gly Leu Glu Asp Met His Met Trp Ile Ser Phe Pro 20 25 30 Phe Cys Ser Met Tyr Ala Val Ala Met Val Gly Asn Cys Gly Leu Leu 35 40 45 Tyr Leu Ile Tyr Tyr Glu Asp Ser Leu His Arg Ser Met Tyr Tyr Phe 50 55 60 Leu Ala Met Leu Ser Leu Thr Asp Leu Val Met Cys Ser Ser Thr Ile 65 70 75 80

Page 3855

Pro Lys Ala Leu Ser 85 Ile Phe 069269_0225_SL.TXT Ile Arg 95 Phe Trp Cys His 90 Leu Lys Glu Glu Glu Cys Leu Val Gln Met Phe Phe Ile His Thr Phe Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg Tyr Ser Thr Ile Leu Thr Asn Pro Val Ile Ala 130 135 140 Lys Val Gly Leu Ala Thr Phe Leu Arg Ala Val Phe Leu Ile Ile Pro 145 150 155 160 Leu Ile Phe Leu Thr Lys Arg Leu Pro Tyr Cys Lys Gly Asn Ile Ile 165 170 175 His His Thr Tyr Cys Asp Gln Leu Ser Val Ala Lys Leu Ser Cys Gly 180 185 190 Asn Ile Lys Ala Asn Val Ile Tyr Gly Leu Val Ala Ala Phe Leu Ile 195 200 205 Gly Gly Phe Asp Ile Leu Cys Ile Thr Val Ser Tyr Thr Met Ile Leu 210 215 220 Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe 225 230 235 240 Ser Thr Cys Thr Ala His Ile Cys Ala Ile Val Phe Ser Tyr Ser Pro 245 250 255 Ala Phe Phe Cys Phe Phe Phe Asn Arg Phe Gly Ser His Thr Ile Pro 260 265 270 Pro Ser Cys His Ile Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro Pro 275 280 285

Page 3856

069269_0225_SL.TXT Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Asp 290 295 300

Cys Val Ile Arg Ile Phe Ser Gly Ser Lys Lys Ile Lys Ser Tyr Ser 305 310 315 320

Thr <210> 3447 <211> 966 <212> DNA <213> Felis catus <400> 3447

atgctaatgt taaaccaaac agacctgacc ccagcctcat tcattcttaa tgggatccga 60 ggactggagg atgtgcatat gtggatttcc ttcccattct gctccatgta tgctgtggca 120 gtggtaggga attgtgggct cctctacctc atccgctatg aggactccct gcacaggacc 180 atgtactatt tcttggctat gctttcccta actgatctcg tcatgtgcac tactacaatc 240 cctaaagctc tctgcatctt ctggttccac cttaaggaaa tcagttttaa tgaatgccta 300 gtccagatgt tcttcatcta tacctcaaca gggatggaat ctggggtact catgcttatg 360 gcgctggacc gttatgtggc catctgctac cctctgcact actcaactat ccttaccaat 420 cctgtcattg caaaggttgg gcttgctact ttcctgagag tggtgctgct tgtcattcct 480 ttgactttca tcatcaagag gctaccctac tgtagaggga atatactaca ccatacctac 540 tgtgaccata tgtctgtagc caagttatcc tgtggaaata tcaaggtcaa tgtcatctat 600 ggtctgatgg ttgccctcct gattgggggc tttgacatcc tgtgcatcac aatctcctac 660 accatgatcc tccgggcagt agtcagcctc tcctcagcag atgctcggca gaaggccttc 720 agcacctgca ctgcccacat ctgtgccatc gttttctcct acagtccagc cttcttctgt 780 ttcttttccc accgctttgg gggccacaca atccctccat cttgccacat cattgtggcc 840 aatatttatc tgctcctgcc tcccactatg aaccctattg tctatggagt gaaaaccaaa 900 cagatatgag actgtgtcat aaggatcttt tcaagttcta aggacattaa atcccacagc 960

atatga 966

Page 3857

069269_0225_SL.TXT <210> 3448 <211> 302 <212> PRT <213> Felis catus

<400> 3448 Met 1 Leu Met Leu Asn Gln Thr Asp Leu Thr Pro Ala Ser Phe Ile Leu 5 10 15 Asn Gly Ile Arg Gly Leu Glu Asp Val His Met Trp Ile Ser Phe Pro 20 25 30 Phe Cys Ser Met Tyr Ala Val Ala Val Val Gly Asn Cys Gly Leu Leu 35 40 45 Tyr Leu Ile Arg Tyr Glu Asp Ser Leu His Arg Thr Met Tyr Tyr Phe 50 55 60 Leu Ala Met Leu Ser Leu Thr Asp Leu Val Met Cys Thr Thr Thr Ile 65 70 75 80 Pro Lys Ala Leu Cys Ile Phe Trp Phe His Leu Lys Glu Ile Ser Phe 85 90 95 Asn Glu Cys Leu Val Gln Met Phe Phe Ile Tyr Thr Ser Thr Gly Met 100 105 110 Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile 115 120 125 Cys Tyr Pro Leu His Tyr Ser Thr Ile Leu Thr Asn Pro Val Ile Ala 130 135 140 Lys Val Gly Leu Ala Thr Phe Leu Arg Val Val Leu Leu Val Ile Pro 145 150 155 160 Leu Thr Phe Ile Ile Lys Arg Leu Pro Tyr Cys Arg Gly Asn Ile Leu 165 170 175 His His Thr Tyr Cys Asp His Met Ser Val Ala Lys Leu Ser Cys Gly

Page 3858

069269_0225_SL.TXT

180 185 190

Asn Ile Lys Val Asn Val 195 Ile Tyr Gly Leu Met Val Ala Leu Leu Ile 200 205 Gly Gly Phe Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu 210 215 220 Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe 225 230 235 240 Ser Thr Cys Thr Ala His Ile Cys Ala Ile Val Phe Ser Tyr Ser Pro 245 250 255 Ala Phe Phe Cys Phe Phe Ser His Arg Phe Gly Gly His Thr Ile Pro 260 265 270 Pro Ser Cys His Ile Ile Val Ala Asn Ile Tyr Leu Leu Leu Pro Pro 275 280 285 Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile 290 295 300

<210> 3449 <211> 960 <212> DNA <213> Felis catus <400> 3449

atgttccagc atcccggaga ttccaacatc tctaagttcc aggtctctga gttcattctg 60 atgggattcc caggcattca cacctggcag cactggctct ccctgcccct ggctctgctc 120 tacctcttag ctctcactgc caacatcctt atcctgatca tcatcaatca ggagaccaca 180 ctgcatcagc ctatgtacta tttcctaggg gtcctggcgg tagtagacat gggtctgggt 240 accaacatca tgcccaaaat tttggctatt ttatggttca atgctaaggc catcagtctc 300 cctgagtgct ttgtgcagat gtatgctata cattgcttta tgggcatgga gtcaggtatc 360 tttgtctgta tggctataga tagatatgta gccatttgta aaccactaca ctatccagca 420 ataatcactg aatcttttgt ggtcaaagca actgtgctca tggctctccg aaatacccta 480

Page 3859

069269_0225_SL.TXT

actaccatcc cagtgcctgt gttggctgct cagagacact actgctcaca gaaccaaatt 540 gagcactgcc tgtgctctaa tcttggagtc actagcttat cctgtgatga caggacaatt 600 aacagcatct accagctact tctggcatgg acactgatgg ggagtgacct ggctttgatt 660 tttttatcat atgttttgat acttcactca gtgctgaagc tgaactcagc agaagctgct 720 tccaaagccc taagtacctg cacttcccac ttcatcctaa tcttattctt ctacacagtt 780 gtcattgtca tttccatcac ccatagtgaa gcaatcacgc ttccccttgt cccagttctt 840 ctcaatgtac ttcaaaatac cattcctcct gccctcaacc ccatggtgta tgcactcaag 900 aataaggagc tgagacaggg cttgcataag tttctaaagc tagacactaa ggacaactaa 960

<210> 3450 <211> 319 <212> PRT <213> Felis catus <400> 3450

Met Phe Gln His Pro Gly Asp Ser Asn Ile Ser Lys Phe Gln Val Ser 1 5 10 15 Glu Phe Ile Leu Met Gly Phe Pro Gly Ile His Thr Trp Gln His Trp 20 25 30 Leu Ser Leu Pro Leu Ala Leu Leu Tyr Leu Leu Ala Leu Thr Ala Asn 35 40 45 Ile Leu Ile Leu Ile Ile Ile Asn Gln Glu Thr Thr Leu His Gln Pro 50 55 60 Met Tyr Tyr Phe Leu Gly Val Leu Ala Val Val Asp Met Gly Leu Gly 65 70 75 80 Thr Asn Ile Met Pro Lys Ile Leu Ala Ile Leu Trp Phe Asn Ala Lys 85 90 95 Ala Ile Ser Leu Pro Glu Cys Phe Val Gln Met Tyr Ala Ile His Cys 100 105 110

Page 3860

Phe Met Gly 115 Met Glu Ser Gly 069269_0225_SL.TXT Ile Phe Val Cys Met Ala 120 125 Ile Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Pro Ala Ile Ile Thr Glu 130 135 140 Ser Phe Val Val Lys Ala Thr Val Leu Met Ala Leu Arg Asn Thr Leu 145 150 155 160 Thr Thr Ile Pro Val Pro Val Leu Ala Ala Gln Arg His Tyr Cys Ser 165 170 175 Gln Asn Gln Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Thr Ser 180 185 190 Leu Ser Cys Asp Asp Arg Thr Ile Asn Ser Ile Tyr Gln Leu Leu Leu 195 200 205 Ala Trp Thr Leu Met Gly Ser Asp Leu Ala Leu Ile Phe Leu Ser Tyr 210 215 220 Val Leu Ile Leu His Ser Val Leu Lys Leu Asn Ser Ala Glu Ala Ala 225 230 235 240 Ser Lys Ala Leu Ser Thr Cys Thr Ser His Phe Ile Leu Ile Leu Phe 245 250 255 Phe Tyr Thr Val Val Ile Val Ile Ser Ile Thr His Ser Glu Ala Ile 260 265 270 Thr Leu Pro Leu Val Pro Val Leu Leu Asn Val Leu Gln Asn Thr Ile 275 280 285 Pro Pro Ala Leu Asn Pro Met Val Tyr Ala Leu Lys Asn Lys Glu Leu 290 295 300 Arg Gln Gly Leu His Lys Phe Leu Lys Leu Asp Thr Lys Asp Asn 305 310 315

Page 3861

069269_0225_SL.TXT <210> 3451 <211> 957 <212> DNA <213> Felis catus <400> 3451

atgttccagc atcccggaga ttccaacatc tctaagttcc aggtctctga gttcattctg 60 atgggattcc caggcattca cacctggcag cactggctct ccctgcccct ggcactgctc 120 taccttttag ctctcactgc caacatcctt atcctgatca tcatcaatca ggaggccaca 180 ctgcaccaac ctatgtacca tttcctgggg atcctggctg tggtagacat gggactggct 240 accaccatca tgcccaagat tttggccatc ttatggttca gtgccaaggc catcagtctc 300 cctgagtgtt ttgctcagat gtatgtcata cattgcttcg tgggcatgga gtcaggtatc 360 tttgtctgca tggctataga tagatatgta gccatttgca aaccattaca ctatccagca 420 ataatcactg aatcttttgt ggtcaaagca actgtgctca tggccctccg aaatacccta 480 actaccatcc cagtgcctgt tttggctgct cagagacact actgctcaca gaaccaaatt 540 gagcactgcc tgtgctctaa tcttggagtc actagcttat cctgtgatga caggacaatt 600 aacagcatct accagctact tctggcatgg acactgatgg ggagtgacct ggctttgatt 660 tttttatcat atgttttgat acttcactca gtgctgaagc tgaactcagc agaagctgct 720 tccaaagccc taagtacctg cacttcccac ctcatcctaa tcctattctt ctacacagtt 780 gtcattgtca tttctatcac ccataatgca acaatgacgt ttccccttgt cccagttcta 840 ctcaatgtac tacacaatgt cattcctcct gccctcaacc ccatggtata tgcactcaag 900 aacaaggagc tcatgcaggg cttgtataag cttctgaagc tgaacatcaa aggcaac 957

<210> 3452 <211> 319 <212> PRT <213> Felis catus <400> 3452

Met Phe Gln His Pro Gly Asp Ser Asn Ile Ser Lys Phe Gln Val Ser 1 5 10 15

Glu Phe Ile Leu Met Gly Phe Pro Gly Ile His Thr Trp Gln His Trp 20 25 30

Page 3862

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Leu Ser Leu 35 Pro Leu Ala Leu Leu Tyr Leu Leu Ala Leu Thr Ala Asn 40 45 Ile Leu Ile Leu Ile Ile Ile Asn Gln Glu Ala Thr Leu His Gln Pro 50 55 60 Met Tyr His Phe Leu Gly Ile Leu Ala Val Val Asp Met Gly Leu Ala 65 70 75 80 Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Leu Trp Phe Ser Ala Lys 85 90 95 Ala Ile Ser Leu Pro Glu Cys Phe Ala Gln Met Tyr Val Ile His Cys 100 105 110 Phe Val Gly Met Glu Ser Gly Ile Phe Val Cys Met Ala Ile Asp Arg 115 120 125 Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Pro Ala Ile Ile Thr Glu 130 135 140 Ser Phe Val Val Lys Ala Thr Val Leu Met Ala Leu Arg Asn Thr Leu 145 150 155 160 Thr Thr Ile Pro Val Pro Val Leu Ala Ala Gln Arg His Tyr Cys Ser 165 170 175 Gln Asn Gln Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Thr Ser 180 185 190 Leu Ser Cys Asp Asp Arg Thr Ile Asn Ser Ile Tyr Gln Leu Leu Leu 195 200 205 Ala Trp Thr Leu Met Gly Ser Asp Leu Ala Leu Ile Phe Leu Ser Tyr 210 215 220 Val Leu Ile Leu His Ser Val Leu Lys Leu Asn Ser Ala Glu Ala Ala 225 230 235 240

Page 3863

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Ser Lys Ala Leu Ser 245 Thr Cys Thr Phe Tyr Thr Val 260 Val Ile Val Ile Thr Phe Pro 275 Leu Val Pro Val Leu 280 Pro Pro 290 Ala Leu Asn Pro Met 295 Val Met 305 Gln Gly Leu Tyr Lys 310 Leu Leu

Ser His 250 Leu Ile Leu Ile Leu 255 Phe Ser 265 Ile Thr His Asn Ala 270 Thr Met Leu Asn Val Leu His 285 Asn Val Ile Tyr Ala Leu Lys 300 Asn Lys Glu Leu Lys Leu Asn 315 Ile Lys Gly Asn

<210> 3453 <211> 960 <212> DNA <213> Felis catus <400> 3453 atgttccagg atctcacaca ttccaacatc atgggattcc caggcattca cacctggcag tacctcttag ctctcactgc caacatcctt ctgcatcagc ctatgtacta tttcctgggg accaccatca tgcccaagat tttggccatc cctgagtgtt ttgctcagat gtatgtcata tttgtctgca tggctataga tagatatgta atagttactg attcttttgt ggtcaaggca gctaccatcc cagtgcctgt gttggctgct gagcactgcc tgtgctctaa tcttggagtc aacagcatct accagctatt tctggcatgg tttttatcgt atgttttgat acttcactca tccaaagccc taagtacctg tacttcccac tctaagttcc aggtctctga gttcattctg cactggctct ccctgcccct ggctctgctc atcctgatca tcatcaatca ggaggccaca atcctggctg tggtagacat gggactggct ttatggttca gtgccaaggc catcagtctc cattgttttg tggttatgga gtcaggtatc gccatttgca aaccactacg ctatccagca actgtgttca tggcacttag aaacagcctg cagagacact actgctcaca gaaccaaatt actagcttat cctgtgatga caggacaatc acattgatgg ggagtgacct ggttttgatt gtgctgaaac tgaactcagc agaagctgct ctcatcctca ttttgttctt ttacacagtc

120

180

240

300

360

420

480

540

600

660

720

780

Page 3864

069269_0225_SL.TXT attgttgtca ctcaatgtac aataaggaac tttccatcac tacacaatgt tcaggcatgg ccatagtgca cattcctcct cttatataaa gcaatcacgc gccctcaatc gctcttaagt ttccccttgt ccatagtgta tgaacatcaa cccagttctc tgcactcaag aagcaagtaa

840

900

960 <210> 3454 <211> 319 <212> PRT <213> Felis catus

<400> 3454 Thr His Ser Asn Ile Ser Lys Phe Gln Val Ser Met Phe 1 Gln Asp Leu 5 10 15 Glu Phe Ile Leu Met Gly Phe Pro Gly Ile His Thr Trp Gln His Trp 20 25 30 Leu Ser Leu Pro Leu Ala Leu Leu Tyr Leu Leu Ala Leu Thr Ala Asn 35 40 45 Ile Leu Ile Leu Ile Ile Ile Asn Gln Glu Ala Thr Leu His Gln Pro 50 55 60 Met Tyr Tyr Phe Leu Gly Ile Leu Ala Val Val Asp Met Gly Leu Ala 65 70 75 80 Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Leu Trp Phe Ser Ala Lys 85 90 95 Ala Ile Ser Leu Pro Glu Cys Phe Ala Gln Met Tyr Val Ile His Cys 100 105 110 Phe Val Val Met Glu Ser Gly Ile Phe Val Cys Met Ala Ile Asp Arg 115 120 125 Tyr Val Ala Ile Cys Lys Pro Leu Arg Tyr Pro Ala Ile Val Thr Asp 130 135 140 Ser Phe Val Val Lys Ala Thr Val Phe Met Ala Leu Arg Asn Ser Leu 145 150 155 160

Page 3865

069269_0225_SL.TXT

Ala Thr Ile Pro Val Pro Val Leu Ala Ala Gln Arg His Tyr Cys Ser 165 170 175 Gln Asn Gln Ile Glu His Cys Leu Cys Ser Asn Leu Gly Val Thr Ser 180 185 190 Leu Ser Cys Asp Asp Arg Thr Ile Asn Ser Ile Tyr Gln Leu Phe Leu 195 200 205 Ala Trp Thr Leu Met Gly Ser Asp Leu Val Leu Ile Phe Leu Ser Tyr 210 215 220 Val Leu Ile Leu His Ser Val Leu Lys Leu Asn Ser Ala Glu Ala Ala 225 230 235 240 Ser Lys Ala Leu Ser Thr Cys Thr Ser His Leu Ile Leu Ile Leu Phe 245 250 255 Phe Tyr Thr Val Ile Val Val Ile Ser Ile Thr His Ser Ala Ala Ile 260 265 270 Thr Leu Pro Leu Val Pro Val Leu Leu Asn Val Leu His Asn Val Ile 275 280 285 Pro Pro Ala Leu Asn Pro Ile Val Tyr Ala Leu Lys Asn Lys Glu Leu 290 295 300 Arg His Gly Leu Tyr Lys Ala Leu Lys Leu Asn Ile Lys Ser Lys

305 310 315 <210> 3455 <211> 860 <212> DNA <213> Felis catus <400> 3455 ttaaatgttg tgagaattgt ccttttcctt aaacaagaat ctaataacaa tttctcgtat ctgcttggtt ttcaccccat acacaatagg gttcattgtg ggaggcatga gcaggtagag

120

Page 3866

069269_0225_SL.TXT

attagccata ataatgtgta tatgtggagg aatggtgtgt cccccaaacc ggtgagtaaa 180 gaaggtgaag aaggctggga cataggtgat gacaatggca cagatgtgag cagtgcatgt 240 gctaaaggcc ttctgccggg catctgctga tgatagactc acaactgccc ggaggatcat 300 agtgtaggag attgtgatgc acaggatgtc aaagccccca atcaggaggg caaccattaa 360 accatatatg gcattgatcc taacattacc acaggatatc ttggccacag acatgtggtc 420 acagtaggtg tgaggtatga cattgcccct gcagtatggc aggtgcttgg tgaggaaagt 480 gaaagggata acaagtatta cacctctaag aaaagtgagg agtccagcct tggaaatgac 540 tgaatttgtg aggatagtag catagcgcag gggatagcag atggccacat agcggtccag 600 ggccatgagc atgagcaccc cagactccat tcctgtgaaa gtgtgcacaa agaacatctg 660 ggccaggcag gccttgaaat caatctcctt gaggttgaac cacaatatgc agagggtgtt 720 gggaagagtg ctggtgcaca tgagcacatc tgtgaaggat agaagggcta ggaaaatgta 780 cataggtctg tgtagggctt cttcagagta aatgaggtat ataagaccaa agtttcctgt 840 gattgcaatg gctgtacatg 860 <210> 3456 <211> 285 <212> PRT <213> Felis catus <400> 3456 Cys Thr Ala Ile Ala Ile Thr Gly Asn Phe Gly Leu Ile Tyr Leu Ile 1 5 10 15 Tyr Ser Glu Glu Ala Leu His Arg Pro Met Tyr Ile Phe Leu Ala Leu 20 25 30 Leu Ser Phe Thr Asp Val Leu Met Cys Thr Ser Thr Leu Pro Asn Thr 35 40 45 Leu Cys Ile Leu Trp Phe Asn Leu Lys Glu Ile Asp Phe Lys Ala Cys 50 55 60 Leu Ala Gln Met Phe Phe Val His Thr Phe Thr Gly Met Glu Ser Gly 65 70 75 80

Page 3867

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Val Leu Met Leu Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Tyr Pro 85 90 95 Leu Arg Tyr Ala Thr Ile Leu Thr Asn Ser Val Ile Ser Lys Ala Gly 100 105 110 Leu Leu Thr Phe Leu Arg Gly Val Ile Leu Val Ile Pro Phe Thr Phe 115 120 125 Leu Thr Lys His Leu Pro Tyr Cys Arg Gly Asn Val Ile Pro His Thr 130 135 140 Tyr Cys Asp His Met Ser Val Ala Lys Ile Ser Cys Gly Asn Val Arg 145 150 155 160 Ile Asn Ala Ile Tyr Gly Leu Met Val Ala Leu Leu Ile Gly Gly Phe 165 170 175 Asp Ile Leu Cys Ile Thr Ile Ser Tyr Thr Met Ile Leu Arg Ala Val 180 185 190 Val Ser Leu Ser Ser Ala Asp Ala Arg Gln Lys Ala Phe Ser Thr Cys 195 200 205 Thr Ala His Ile Cys Ala Ile Val Ile Thr Tyr Val Pro Ala Phe Phe 210 215 220 Thr Phe Phe Thr His Arg Phe Gly Gly His Thr Ile Pro Pro His Ile 225 230 235 240 His Ile Ile Met Ala Asn Leu Tyr Leu Leu Met Pro Pro Thr Met Asn 245 250 255 Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Ile Val Ile 260 265 270 Arg Phe Leu Phe Lys Glu Lys Asp Asn Ser His Asn Ile 275 280 285

Page 3868

069269_0225_SL.TXT <210> 3457 <211> 715 <212> DNA <213> Felis catus <400> 3457

tgctgtgcat attctggttc aacctcaagg agattgactt tgatgcctgc ctggctcaga 60 tgttttcgtc cacatgctga ctgggatgga gtctggggtg ctcatgctca tggccctgga 120 ccgctatgtg gccatctgct accccttacg ttattccatc atcctcacca accctgtcat 180 cgccaagacc ggtcttgcca ccttcctgag gggtgtgctg ctcattatcc cattcacttt 240 cctcaccaag cgtctgccct attgccgggg caacttcatt ccccatacct actgtgatca 300 tatgtctgtg gccaaggtgt cctgtggcaa tttcaaggtc aatgccatct atggtctctt 360 ggcagccctc ctaattgggg gctttgatat gttctgtatt tctgtgtctt acactatgat 420 cttgcgggca gtggtgagtt tgtcatctgc agatgctcgg aagaaagcct tcggtacctg 480 tacatcccac atatgtgcca ttgtgatcac atatgttcca gccctgttca ccatttttac 540 tcatcgtttt gggggacaaa acattcccca ccacgttcat atccttattg ctaatcttta 600 tttgatgttg cctcctactc tgaaccccat tgtttatgga gccaagacca agcagatcca 660 ggaaggagtg atcaagttat tttttaaaga gaaaactatc ttagttatga gatag 715

<210> 3458 <211> 213 <212> PRT <213> Felis catus <400> 3458

Met 1 Leu Thr Gly Met Glu Ser Gly Val Leu Met Leu Met Ala Leu Asp 5 10 15 Arg Tyr Val Ala Ile Cys Tyr Pro Leu Arg Tyr Ser Ile Ile Leu Thr 20 25 30 Asn Pro Val Ile Ala Lys Thr Gly Leu Ala Thr Phe Leu Arg Gly Val 35 40 45 Leu Leu Ile Ile Pro Phe Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys

50 55 60

Page 3869

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Arg Gly Asn Phe 65 Ile Pro His Thr Tyr Cys Asp His Met Ser Val Ala 70 75 80 Lys Val Ser Cys Gly Asn Phe Lys Val Asn Ala Ile Tyr Gly Leu Leu 85 90 95 Ala Ala Leu Leu Ile Gly Gly Phe Asp Met Phe Cys Ile Ser Val Ser 100 105 110 Tyr Thr Met Ile Leu Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala 115 120 125 Arg Lys Lys Ala Phe Gly Thr Cys Thr Ser His Ile Cys Ala Ile Val 130 135 140 Ile Thr Tyr Val Pro Ala Leu Phe Thr Ile Phe Thr His Arg Phe Gly 145 150 155 160 Gly Gln Asn Ile Pro His His Val His Ile Leu Ile Ala Asn Leu Tyr 165 170 175 Leu Met Leu Pro Pro Thr Leu Asn Pro Ile Val Tyr Gly Ala Lys Thr 180 185 190 Lys Gln Ile Gln Glu Gly Val Ile Lys Leu Phe Phe Lys Glu Lys Thr 195 200 205 Ile Leu Val Met Arg

210 <210> 3459 <211> 885 <212> DNA <213> Felis catus <400> 3459 gatctccctg ccattctgct tcatgtacgt catcgctgtc gtggggaact gcgggctcat ctacctaatc agccatgagg atgccctgca ccggcccatg tactacttcc tggccctgct

120

Page 3870

069269_0225_SL.TXT

cgccttcaca gatgtcaccc tgtgcaccac cactgtaccc aatatgctgt gcatattctg 180 gttcaacctc aaggagattg actttgatgc ctgcctggct cagatgtttt tcgtccacat 240 gctgactggg atggagtctg gggtgctcat gctcatggcc ctggaccgct atgtggccat 300 ctgctacccc ttacgttatt ccatcatcct caccaaccct gtcatcgcca agaccggtct 360 tgccaccttc ctgaggggtg tgctgctcat tatcccattc actttcctca ccaagcgtct 420 gccctattgc cggggcaact tcattcccca tacctactgt gatcatatgt ctgtggccaa 480 ggtgtcctgt ggcaatttca aagtcaatgc tgtctatggt ctgatggttg ctctccttat 540 tggtgtgttt gacatctgct gtatttctgt gtcttacact atgatattga gagcagtagt 600 gagcctgtca tctgcagatg ctcgtcaaaa agcctttagc acctgtacat cccacatatg 660 tgccattgtg atcacttatg ttccagcttt tttcactttt tttgcccacc gttttggagg 720 acacaatatc ccccaccaca ttcacatcat tgtagccaac ctttacctgc tcctacctcc 780 tacaatgaat cctattgttt atggagtcaa gaccaagcag atccgagaag gtgtgttcaa 840 gtttttactt ggacacaagg ttgtctttac tcaagacaaa tgaat 885

<210> 3460 <211> 293 <212> PRT <213> Felis catus <400> 3460

Ile Ser Leu Pro Phe Cys Phe Met Tyr Val Ile Ala Val Val Gly Asn 1 5 10 15 Cys Gly Leu Ile Tyr Leu Ile Ser His Glu Asp Ala Leu His Arg Pro 20 25 30 Met Tyr Tyr Phe Leu Ala Leu Leu Ala Phe Thr Asp Val Thr Leu Cys 35 40 45 Thr Thr Thr Val Pro Asn Met Leu Cys Ile Phe Trp Phe Asn Leu Lys 50 55 60 Glu Ile Asp Phe Asp Ala Cys Leu Ala Gln Met Phe Phe Val His Met 65 70 75 80

Page 3871

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Leu Thr Gly Met Glu 85 Ser Gly Val Leu Met 90 Leu Met Ala Leu Asp 95 Arg Tyr Val Ala Ile Cys Tyr Pro Leu Arg Tyr Ser Ile Ile Leu Thr Asn 100 105 110 Pro Val Ile Ala Lys Thr Gly Leu Ala Thr Phe Leu Arg Gly Val Leu 115 120 125 Leu Ile Ile Pro Phe Thr Phe Leu Thr Lys Arg Leu Pro Tyr Cys Arg 130 135 140 Gly Asn Phe Ile Pro His Thr Tyr Cys Asp His Met Ser Val Ala Lys 145 150 155 160 Val Ser Cys Gly Asn Phe Lys Val Asn Ala Val Tyr Gly Leu Met Val 165 170 175 Ala Leu Leu Ile Gly Val Phe Asp Ile Cys Cys Ile Ser Val Ser Tyr 180 185 190 Thr Met Ile Leu Arg Ala Val Val Ser Leu Ser Ser Ala Asp Ala Arg 195 200 205 Gln Lys Ala Phe Ser Thr Cys Thr Ser His Ile Cys Ala Ile Val Ile 210 215 220 Thr Tyr Val Pro Ala Phe Phe Thr Phe Phe Ala His Arg Phe Gly Gly 225 230 235 240 His Asn Ile Pro His His Ile His Ile Ile Val Ala Asn Leu Tyr Leu 245 250 255 Leu Leu Pro Pro Thr Met Asn Pro Ile Val Tyr Gly Val Lys Thr Lys 260 265 270 Gln Ile Arg Glu Gly Val Phe Lys Phe Leu Leu Gly His Lys Val Val 275 280 285

Page 3872

069269_0225_SL.TXT

Phe Thr Gln Asp Lys 290 <210> 3461 <211> 931 <212> DNA <213> Felis catus <400> 3461

atgtccccct caaatgatac caagctccac ccctcctatt tcctcctgct gggagttcca 60 ggtcttgaac agatgcacat ctggattggg tttccttttt gttctgtgta tttgattgcc 120 cttgtgggga acatcactat cctgtttgtg atcaagactg aacacagcct tcatcagcct 180 atgttttact tcttggctat gttagcctcc attgatctgg gcctgtccac atccaccatc 240 cccaaaatgt taggcatatt ctggtttaat ttaaaggaga ttagctttga gggctgtgtc 300 acccagatgt tctttattca tatattcact gccatggaga ctgtcgtgtt ggtggccatg 360 gcctttgatc gccatgttgc tgtctgcaac cctctgcgat acagcctgat tctcactaac 420 agaacgattg gtctcatcct tgttgttgtg tttggtgtca atttcatttt ggttatccct 480 ctggtgtttc tcatcttgag acttcccttt tgtggacacc atgtaatccc ccacacatac 540 tgtgagcaca tgggaattgc tcgcctagcc tgtgccaata taaaggtcaa catgatattt 600 ggattaattc ttatatcact ggtgtttgtt gacgtggttc tgatcgtcat ctcctatgtg 660 agaatactcc gagctgtctt ctgccttcct tcccaggatg ccagactcaa agcacttaat 720 acatgtggct cccatatctg tgttatccta gccttcttta ctccagcttt tttctccttc 780 atgactcacc ggtttggcag gaacgttccc gtatacattc atattctcct tgccaatcta 840 tatgtggttg ttccacctgc cctcaatcct gtcatctatg gagtgaggac caagcaaatt 900 cgagaaaggg tttcaagcat ctttttgaaa a 931

<210> 3462 <211> 311 <212> PRT <213> Felis catus <220>

<221> MOD_RES

Page 3873

069269_0225_SL.TXT <222> (311)..(311) <223> Any amino acid

<400> 3462 Leu 15 Leu Met 1 Ser Pro Ser Asn 5 Asp Thr Lys Leu His 10 Pro Ser Tyr Phe Leu Gly Val Pro Gly Leu Glu Gln Met His Ile Trp Ile Gly Phe Pro 20 25 30 Phe Cys Ser Val Tyr Leu Ile Ala Leu Val Gly Asn Ile Thr Ile Leu 35 40 45 Phe Val Ile Lys Thr Glu His Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Ser Ile Asp Leu Gly Leu Ser Thr Ser Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Lys Glu Ile Ser Phe 85 90 95 Glu Gly Cys Val Thr Gln Met Phe Phe Ile His Ile Phe Thr Ala Met 100 105 110 Glu Thr Val Val Leu Val Ala Met Ala Phe Asp Arg His Val Ala Val 115 120 125 Cys Asn Pro Leu Arg Tyr Ser Leu Ile Leu Thr Asn Arg Thr Ile Gly 130 135 140 Leu Ile Leu Val Val Val Phe Gly Val Asn Phe Ile Leu Val Ile Pro 145 150 155 160 Leu Val Phe Leu Ile Leu Arg Leu Pro Phe Cys Gly His His Val Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala 180 185 190

Page 3874

Asn Ile Lys 195 Val Asn Met Ile 069269_0225_SL.TXT Phe Gly Leu Ile Leu Ile 200 205 Ser Leu Val Phe Val Asp Val Val Leu Ile Val Ile Ser Tyr Val Arg Ile Leu Arg 210 215 220 Ala Val Phe Cys Leu Pro Ser Gln Asp Ala Arg Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Gly Ser His Ile Cys Val Ile Leu Ala Phe Phe Thr Pro Ala 245 250 255 Phe Phe Ser Phe Met Thr His Arg Phe Gly Arg Asn Val Pro Val Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Ala Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg Val 290 295 300 Ser Ser Ile Phe Leu Lys Xaa 305 310

<210> 3463 <211> 942 <212> DNA <213> Felis catus <400> 3463

tcaaacttcc ttaaaaagga agatcatcac cacctgttct cggatctgct tagttctcac 60 cccataaata atggggttaa gagcaggtgg gattatcaca tataaatttg ccaggaggat 120 gtggatataa cgtggaatat tgtggccaaa tcgatgagtc ataaaagaga aaaatgctgg 180 agtgaaaaaa gctaagatga cacatacatg ggaaccacag gtattaagag ctttgagcct 240 ggcctcccag gatgggagtc tgaagacagc acgtagaatc ttcacatagg agatagcaat 300 caaaataaca tccagaagta tcatagagat aagaattaat ccaaataata tattgacctt 360 tatgctgaca caggccagac gggcaatgcc catgtgctca cagtaggtat ggggtataat 420

Page 3875

069269_0225_SL.TXT

attatgtcca cagaatgaaa gccttagaag gagaaacaca agtggaaaca ccaaaacaaa 480 atttttcaac attcctactc cagcaataat acaaatagtt ctgttggtaa ggattgtgtt 540 gtatcgaaga gggtggcaaa tggcaacata gcgatcaaaa gccatggcaa caagcatgaa 600 agtttcgaaa cctgtaaaca ggtgtatgaa gaacatttga gctaagcatc ccccaaagtc 660 aatctcattg agaccaaacc agaatatgct cagcattttg ggaatagttg cggtggagag 720 gcccaggtca gtgagagcca acatggccaa taagtagaac atgggatggt gaaggctgtg 780 ctcagtctgg atcacaaaga ggatgatgcc attccccagg agggcaatca gatagactgt 840 accaaatggg acaccaagcc agagctgcat attttccagt cctgggattc ccaacagcag 900 gaaagatgag gggtgaaaac atgaggtatt ggctagagac at 942

<210> 3464 <211> 313 <212> PRT <213> Felis catus

<400> 3464 Thr Ser Cys Phe His Pro Ser Ser Phe Leu Leu Met Ser 1 Leu Ala Asn 5 10 15 Leu Gly Ile Pro Gly Leu Glu Asn Met Gln Leu Trp Leu Gly Val Pro 20 25 30 Phe Gly Thr Val Tyr Leu Ile Ala Leu Leu Gly Asn Gly Ile Ile Leu 35 40 45 Phe Val Ile Gln Thr Glu His Ser Leu His His Pro Met Phe Tyr Leu 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Ser Ile Phe Trp Phe Gly Leu Asn Glu Ile Asp Phe 85 90 95 Gly Gly Cys Leu Ala Gln Met Phe Phe Ile His Leu Phe Thr Gly Phe 100 105 110

Page 3876

069269_0225_SL.TXT

Glu Thr Phe Met 115 Leu Val Ala Met 120 Ala Phe Asp Arg Tyr Val 125 Ala Ile Cys His Pro Leu Arg Tyr Asn Thr Ile Leu Thr Asn Arg Thr Ile Cys 130 135 140 Ile Ile Ala Gly Val Gly Met Leu Lys Asn Phe Val Leu Val Phe Pro 145 150 155 160 Leu Val Phe Leu Leu Leu Arg Leu Ser Phe Cys Gly His Asn Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Val 180 185 190 Ser Ile Lys Val Asn Ile Leu Phe Gly Leu Ile Leu Ile Ser Met Ile 195 200 205 Leu Leu Asp Val Ile Leu Ile Ala Ile Ser Tyr Val Lys Ile Leu Arg 210 215 220 Ala Val Phe Arg Leu Pro Ser Trp Glu Ala Arg Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Ile Leu Ala Phe Phe Thr Pro Ala 245 250 255 Phe Phe Ser Phe Met Thr His Arg Phe Gly His Asn Ile Pro Arg Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Ile Ile Pro Pro Ala Leu 275 280 285 Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Gln Val 290 295 300 Val Met Ile Phe Leu Phe Lys Glu Val 305 310

Page 3877

069269_0225_SL.TXT <210> 3465 <211> 928 <212> DNA <213> Felis catus <400> 3465 ttaactgtct tttaaaaaga tcctcaaaac ctgctcctta atctgcttgg tcctgacccc 60 atagattaca ggattgagag ctggcggaac aaccacatat aggttggcta agaggatgtg 120 gatatattga gggatgttgt ggccaaaacg gtgtgtcaag aaagagaaaa atgctggtgt 180 gaaaaaggct aagataacac caatgtgaga gccacaggtg ttgagagctt tgaaccgggc 240 ctcccaggaa ggcaggcaga agacagcata gaggatcctg acataggaga gaattataag 300 gaacacatcc aataataaaa tagacatatc cccaagacca aatattatgt tgactttgat 360 gctggcacag gccaggcgag caatgcccat gtgttcacag taggtatgag ggatgatata 420 gtgcccacag aagggcagcc tcaagaggag aaataccaga ggggccacca tgcacaggct 480 cctcagaata gccatgcctg caatgaggct gatgattttg ctggtgagga tcatggtgta 540 ccgaaggggt ttacaaatgg caacatagcg gtcaaaggcc atggccacca acacaatgct 600 ctccatggca gtgaagaagt ggatgaagaa catctgggaa aggcagcttt caaaagatat 660 atccctgagg ctgaaccaga agatgcccag cattttgggg atggtggctg tggacaagcc 720 caggtcgatg gagtccaaca tggctaggaa gtagtacacg ggctcatgga gactatgctc 780 agtctggatc acaaacagga cagcagcgtt ccccaagagt gcaacaagat acgcaaagaa 840 aaagggaaat ccaatccaga cgtgcacatc ttctagccct gggataccca ggaggaggaa 900 cgaagaagga tggaactggg tgtcatta 928 <210> 3466 <211> 308 <212> PRT <213> Felis catus <400> 3466

Asn Asp Thr Gln Phe His Pro Ser Ser Phe Leu Leu Leu Gly Ile Pro 1 5 10 15

Gly Leu Glu Asp Val His Val Trp Ile Gly Phe Pro Phe Phe Phe Ala 20 25 30

Page 3878

069269_0225_SL.TXT

Tyr Leu Val 35 Ala Leu Leu Gly Asn Ala Ala Val Leu Phe Val Ile Gln 40 45 Thr Glu His Ser Leu His Glu Pro Val Tyr Tyr Phe Leu Ala Met Leu 50 55 60 Asp Ser Ile Asp Leu Gly Leu Ser Thr Ala Thr Ile Pro Lys Met Leu 65 70 75 80 Gly Ile Phe Trp Phe Ser Leu Arg Asp Ile Ser Phe Glu Ser Cys Leu 85 90 95 Ser Gln Met Phe Phe Ile His Phe Phe Thr Ala Met Glu Ser Ile Val 100 105 110 Leu Val Ala Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu 115 120 125 Arg Tyr Thr Met Ile Leu Thr Ser Lys Ile Ile Ser Leu Ile Ala Gly 130 135 140 Met Ala Ile Leu Arg Ser Leu Cys Met Val Ala Pro Leu Val Phe Leu 145 150 155 160 Leu Leu Arg Leu Pro Phe Cys Gly His Tyr Ile Ile Pro His Thr Tyr 165 170 175 Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala Ser Ile Lys Val 180 185 190 Asn Ile Ile Phe Gly Leu Gly Asp Met Ser Ile Leu Leu Leu Asp Val 195 200 205 Phe Leu Ile Ile Leu Ser Tyr Val Arg Ile Leu Tyr Ala Val Phe Cys 210 215 220 Leu Pro Ser Trp Glu Ala Arg Phe Lys Ala Leu Asn Thr Cys Gly Ser 225 230 235 240

Page 3879

069269_0225_SL.TXT

His Ile Gly Val Ile Leu Ala Phe Phe Thr Pro Ala Phe Phe Ser Phe 245 250 255 Leu Thr His Arg Phe Gly His Asn Ile Pro Gln Tyr Ile His Ile Leu 260 265 270 Leu Ala Asn Leu Tyr Val Val Val Pro Pro Ala Leu Asn Pro Val Ile 275 280 285 Tyr Gly Val Arg Thr Lys Gln Ile Lys Glu Gln Val Leu Arg Ile Phe 290 295 300

Leu Lys Asp Ser

305 <210> 3467 <211> 936 <212> DNA <213> Felis catus <400> 3467 ttatttctgt acaaatatct tcacaactct ctctcggatg tgtttggtcc tgactccata gatgaccgga ttaagggccg gtgggacaac cacataaaga ttagccagaa gaatgtggat atagcgggga atgtttctgc caaaacggtg tgtcataaaa gaaaaaaaag ctggcgtgta aaagcacagc atgacacaga catgagaacc acaggtattg agagccttta gccgggcatc ctgagaagga aggcggaaaa cagctcgaag gataagcaca taggaggagg caatcaggat cacatccaca atgatattag aaatcaccat gagcccatag ataatgttga ccttgatggg tgcacaggcc aaccgggcaa gacccatgtg ctcacagtac gtatgaggga tgatgtgatg cccacagaag ggcaacctca gaatgagaaa cacgaatgga gtcacaagaa ttaaatttct tcccacaaca agagaagcta ggatgctgat ggttttattg gtgaggatca tggtgtactg gagagggttg cagatggcaa caaagcggtc ataagccatg gccaccagga gaacagtctc cattcctgtg aacatgtgga taaagaacat ctgggcaagg cagcccccaa agctgatctc ttgttggttg aaccagaaga tgcccagcat tttggggatg gtggacgtgg acagacccag

120

180

240

300

360

420

480

540

600

660

720

Page 3880 atcgatcata cttgatcaca tgggaaagca ggggggatgg

069269_0225_SL.TXT gacaacatgg ccaggaagta gaacatgggc tggtggagac tgtgttcagt aagagaatgg tgatgttccc cacaagggca atcaggtaca caatgcagaa atccagatat gtacagtttc cagtcctggg attcctagca ggtgaaacaa aagtgggtgt cattgatgga agtcat

780

840

900

936

<210> 3468 <211> 311 <212> PRT <213> Felis <400> 3468 Met Thr Ser 1

catus

Leu Gly Ile

Phe Cys Ile 35

Phe Val Ile 50

Leu Ala Met 65

Pro Lys Met

Gly Gly Cys

Glu Thr Val 115

Cys Asn Pro 130

Ile Leu Ala

Ile Asn 5 Asp Thr His Phe His 10 Pro Pro Pro 20 Gly Leu Glu Thr Val 25 His Ile Trp Val Tyr Leu Ile Ala 40 Leu Val Gly Asn Lys Thr Glu His 55 Ser Leu His Gln Pro 60 Leu Ser Met 70 Ile Asp Leu Gly Leu 75 Ser Leu Gly 85 Ile Phe Trp Phe Asn 90 Gln Gln Leu 100 Ala Gln Met Phe Phe 105 Ile His Met Leu Leu Val Ala Met 120 Ala Tyr Asp Arg Leu Gln Tyr Thr 135 Met Ile Leu Thr Asn 140 Ser Leu Val Val Gly Arg Asn Leu Ile

Leu Phe His 15 Leu Ile Ala 30 Phe Pro Ile 45 Thr Ile Leu Met Phe Tyr Phe Thr Ser Thr Ile 80 Glu Ile Ser 95 Phe Phe Thr 110 Gly Met Phe 125 Val Ala Ile Lys Thr Ile Ser Leu Val Thr Pro

Page 3881

069269_0225_SL.TXT

145 150 Phe 170 155 Cys Gly 160 Phe Val Phe Leu Ile 165 Leu Arg Leu Pro His His Ile Ile 175 Pro His Thr Tyr Cys Glu His Met Gly Leu Ala Arg Leu Ala Cys Ala 180 185 190 Pro Ile Lys Val Asn Ile Ile Tyr Gly Leu Met Val Ile Ser Asn Ile 195 200 205 Ile Val Asp Val Ile Leu Ile Ala Ser Ser Tyr Val Leu Ile Leu Arg 210 215 220 Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Met Leu Cys Phe Tyr Thr Pro Ala 245 250 255 Phe Phe Ser Phe Met Thr His Arg Phe Gly Arg Asn Ile Pro Arg Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Ala Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys His Ile Arg Glu Arg Val 290 295 300 Val Lys Ile Phe Val Gln Lys 305 310 <210> 3469 <211> 943 <212> DNA <213> Felis catus <400> 3469 atgtcttctc ccaatgtcac tgaatcccat cctccttcat tcctattgct ggggattcca gggttggaag ttgcacaaat ctggcttgta tttctcttct gtgctgtgta tctgattgct

120

Page 3882

069269_0225_SL.TXT

cttgttggaa atgttatcat tctgtttgtt atctgggttg atcatagcct tcaccaacct 180 atgttctact ttctggccat gctgtcagtg attggcctaa gtctctctac tactaccatc 240 tccaagatgc tggggatctt ctggttcaga cttcaggagc tgtgctttgg gtgatgtgtt 300 gctcaagtgt tttttatcca cttttttaca gtcatggaga gcattgtact tcttgccatg 360 ggttttgatc attatgtggc tatttgcaac cccctcaggt acagcatgat tcttaccaac 420 agagtgattg gtgtaattgc tgtgatagtg gtactaagaa gcttatgcat gattgttccc 480 atcatttttc tcctcctgag cctgccttac tgtggacaca gaatcatccc tcatacctat 540 tgtgagcaca tgggagtggc acgtctagct tgtgccagca ttaatgccaa tgtctactat 600 ggtcttggaa atatttctat cttgtttctg gatgtgcttc ttatcattgt ctcatatatt 660 aggatcttat atgctgtctt ccacctccct tcccaagatg cccgcctgaa agctctgaat 720 acctgtacct cccatatttg tgttatcttg gtcttctttc gtccagctct cttctctttc 780 ctcactcacc gctttggtca tgacatcccc aagtatatcc atatcctcct ggctaacctc 840 tatgtagtca taccccctgc cctcaaccca gtcatttatg gcatcaggac caagtagatc 900 caggaatggg taaagagtct ctttgttaaa acaagattga tga 943

<210> 3470 <211> 97 <212> PRT <213> Felis catus

<400> 3470 Val Thr Glu Ser His Pro Pro Ser Phe Leu Leu Met 1 Ser Ser Pro Asn 5 10 15 Leu Gly Ile Pro Gly Leu Glu Val Ala Gln Ile Trp Leu Val Phe Leu 20 25 30 Phe Cys Ala Val Tyr Leu Ile Ala Leu Val Gly Asn Val Ile Ile Leu 35 40 45 Phe Val Ile Trp Val Asp His Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60

Page 3883

069269_0225_SL.TXT Leu Ala Met Leu Ser Val Ile Gly Leu Ser Leu Ser Thr Thr Thr Ile 65 70 75 80

Ser Lys Met Leu Gly Ile Phe Trp Phe Arg Leu Gln Glu Leu Cys Phe 85 90 95

Gly <210> 3471 <211> 936 <212> DNA <213> Felis catus <400> 3471

atgacttcca tcaatgacac ccacttccat ccccccttgt ttcacctgct aggaatccca 60 ggactggaaa ctgtacatat ctggattgct ttcccattct gcattgtgta cctgattgcc 120 cttgtgggga acatcaccat tctctttgtg atcaagactg aacacagtct ccaccagccc 180 atgttctact ttctggccat gttgtctatg atcgatctgg gtctgtccac gtccaccatc 240 cccaaaatgc tgggcatctt ctggttcaac caacaagaga tcagctttgg gggctgcctt 300 gcccagatgt tctttatcca catgttcaca ggaatggaga ctgttctcct ggtggccatg 360 gcttatgacc gctttgttgc catctgcaac cctctccagt acaccatgat cctcaccaat 420 aaaaccatca gcatcctagc ttctcttgtt gtgggaagaa atttaattct tgtgactcca 480 ttcgtgtttc tcattctgag gttgcccttc tgtgggcatc acatcatccc tcatacgtac 540 tgtgagcaca tgggtcttgc ccggttggcc tgtgcaccca tcaaggtcaa cattatctat 600 gggctcatgg tgatttctaa tatcattgtg gatgtgatcc tgattgcctc ctcctatgtg 660 cttatccttc gagctgtttt ccgccttcct tctcaggatg cccggctaaa ggctctcaat 720 acctgtggtt ctcatgtctg tgtcatgctg tgcttttaca cgccagcttt tttttctttt 780 atgacacacc gttttggcag aaacattccc cgctatatcc acattcttct ggctaatctt 840 tatgtggttg tcccaccggc ccttaatccg gtcatctatg gagtcaggac caaacacatc 900 cgagagagag ttgtgaagat atttgtatag aaataa 936

<210> 3472

Page 3884

069269_0225_SL.TXT <211> 309 <212> PRT <213> Felis catus

<400> 3472 Met 1 Thr Ser Ile Asn 5 Asp Thr His Phe His Pro Pro Leu Phe His Leu 10 15 Leu Gly Ile Pro Gly Leu Glu Thr Val His Ile Trp Ile Ala Phe Pro 20 25 30 Phe Cys Ile Val Tyr Leu Ile Ala Leu Val Gly Asn Ile Thr Ile Leu 35 40 45 Phe Val Ile Lys Thr Glu His Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ser Met Ile Asp Leu Gly Leu Ser Thr Ser Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Gln Gln Glu Ile Ser Phe 85 90 95 Gly Gly Cys Leu Ala Gln Met Phe Phe Ile His Met Phe Thr Gly Met 100 105 110 Glu Thr Val Leu Leu Val Ala Met Ala Tyr Asp Arg Phe Val Ala Ile 115 120 125 Cys Asn Pro Leu Gln Tyr Thr Met Ile Leu Thr Asn Lys Thr Ile Ser 130 135 140 Ile Leu Ala Ser Leu Val Val Gly Arg Asn Leu Ile Leu Val Thr Pro 145 150 155 160 Phe Val Phe Leu Ile Leu Arg Leu Pro Phe Cys Gly His His Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Leu Ala Arg Leu Ala Cys Ala 180 185 190

Page 3885

069269_0225_SL.TXT

Pro Ile Lys Val Asn Ile 195 Ile Tyr Gly Leu Met Val Ile Ser Asn Ile 200 205 Ile Val Asp Val Ile Leu Ile Ala Ser Ser Tyr Val Leu Ile Leu Arg 210 215 220 Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Met Leu Cys Phe Tyr Thr Pro Ala 245 250 255 Phe Phe Ser Phe Met Thr His Arg Phe Gly Arg Asn Ile Pro Arg Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Ala Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys His Ile Arg Glu Arg Val 290 295 300

Val Lys Ile Phe Val 305 <210> 3473 <211> 942 <212> DNA <213> Felis catus <400> 3473

atgctgcatt ccaacaatac acagtttcac ccctcttcct tccttctggt ggggattcca 60 ggactagaag atgtgcacat ctggattggc ttccccttct ttgcagtgta tctgacagcc 120 ctcctaggga acattactat cctgtttgtg atccagactg aacacagcct ccaccaaccc 180 atgttttact tcctggccat gttggcctgc actgatcttg gcctgtctac agccaccatc 240 cccaagatgc taggaatttt ctggttcaat ctcagggaga ttgggtttgg tgcttgcatc 300 acacagatgt atactatcca tatatgtact ggcctggagt ctgtggtgct gacagtcatg 360 gccatagata gatacattgc catctgtaac cccctgagat atagtatgat cctcaccaat 420

Page 3886

069269_0225_SL.TXT

aaggtgatag ctatcctgag catagtcatc atagtcagga ctttggtgtt tgtgactcca 480 ttcatatttc tcatcctaag attgcctttc tgtggtgtcc gggttattct tcacacctac 540 tgtgaacaca tgggtttggc aaagttggct tgtgccaata ttaggatcaa tgttgtctat 600 ggcttgattg ctttctcagt gggatacatc gacctttctg tgattggatt ctcctacgtt 660 caaatcctcc gagcagtctt ccatctacct tcctgggatg ccaggctcaa ggcacttggc 720 acatgtggct cccatgtctg tgtcatggta gctttctacc taccagccct cttctccttc 780 atgacacatc gctttggcca caacatccct cattacatcc acattcttct ggccaatctg 840 tacgtggttg ttccccctgc tcttaaccct gttatctatg gggtcaggac aaaacagata 900 agagagcgtg tactaaggat gcttaaccct aaaggctatt ga 942

<210> 3474 <211> 313 <212> PRT <213> Felis catus

<400> 3474 Asn Asn 5 Thr Gln Phe His Pro Ser Ser Phe Leu Leu Met 1 Leu His Ser 10 15 Val Gly Ile Pro Gly Leu Glu Asp Val His Ile Trp Ile Gly Phe Pro 20 25 30 Phe Phe Ala Val Tyr Leu Thr Ala Leu Leu Gly Asn Ile Thr Ile Leu 35 40 45 Phe Val Ile Gln Thr Glu His Ser Leu His Gln Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Cys Thr Asp Leu Gly Leu Ser Thr Ala Thr Ile 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe Asn Leu Arg Glu Ile Gly Phe 85 90 95 Gly Ala Cys Ile Thr Gln Met Tyr Thr Ile His Ile Cys Thr Gly Leu 100 105 110

Page 3887

069269_0225_SL.TXT

Glu Ser Val 115 Val Leu Thr Val Met Ala Ile Asp Arg Tyr Ile Ala Ile 120 125 Cys Asn Pro Leu Arg Tyr Ser Met Ile Leu Thr Asn Lys Val Ile Ala 130 135 140 Ile Leu Ser Ile Val Ile Ile Val Arg Thr Leu Val Phe Val Thr Pro 145 150 155 160 Phe Ile Phe Leu Ile Leu Arg Leu Pro Phe Cys Gly Val Arg Val Ile 165 170 175 Leu His Thr Tyr Cys Glu His Met Gly Leu Ala Lys Leu Ala Cys Ala 180 185 190 Asn Ile Arg Ile Asn Val Val Tyr Gly Leu Ile Ala Phe Ser Val Gly 195 200 205 Tyr Ile Asp Leu Ser Val Ile Gly Phe Ser Tyr Val Gln Ile Leu Arg 210 215 220 Ala Val Phe His Leu Pro Ser Trp Asp Ala Arg Leu Lys Ala Leu Gly 225 230 235 240 Thr Cys Gly Ser His Val Cys Val Met Val Ala Phe Tyr Leu Pro Ala 245 250 255 Leu Phe Ser Phe Met Thr His Arg Phe Gly His Asn Ile Pro His Tyr 260 265 270 Ile His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Ala Leu 275 280 285 Asn Pro Val Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg Val 290 295 300 Leu Arg Met Leu Asn Pro Lys Gly Tyr

305 310

Page 3888

069269_0225_SL.TXT <210> 3475 <211> 960 <212> DNA <213> Felis catus <400> 3475

atgatcagga cactttacat ggcctcaccc agcaactact ccactgttcc agtctccgaa 60 ttcctcctca tctgcttccc taactaccag agttggcagc attggttgtc tctgcccctc 120 agcctccttt tcctcctggc catgggggcc aatgccaccc tcctgctcac catccagctg 180 gaggcctctc tgcacgagcc catgtactac ctgctcagcc tcctctccct gctggacatc 240 gtgctctgcc tgactgtcat ccccaaggtc ctggccatct tctggtttga cctcaggtcc 300 atcagcttct ctgcctgctt cctccagatg ttcatcatga acagtttctt gaccatggag 360 tcttgtacat tcatggtcat ggcctatgac cgctatgtgg ccatttgcca cccactgcga 420 tatccatcca taatcactga ccattttgtg gttagagcta ccatatttgt tgtggcccgg 480 aatggcctct tttctcttcc tgttcctgtc ctgtcttctc gactcacata ctgtgcagag 540 aacaccatca agaactgcat ctgcactaac ctgtctgtgt ccaaactatc ctgtgatgac 600 atcaccttca accggctcta ccaatttgtg gcaggctgga ccctcctggg ctctgacctc 660 atccttattg ttctctccta ctccttcatc ctgaaagctg tgctaaggat caaggctgag 720 ggtgctgcgg ccaaggccct gagcacgtgc ggttcccact tcatcctcat cctcttcttc 780 agcaccgtcc tgctggttct ggtcatcact aacctggcca ggaagagaat tcccccagat 840 gtccccatcc tgctcaacat cctgcaccac ctcatccccc cagctctgaa ccccattgtt 900 tatggtgtga ggaccaaaga gatcaagcag ggaatccaga agttactgag gaggttgtaa 960

<210> 3476 <211> 319 <212> PRT <213> Felis catus <400> 3476

Met Ile Arg Thr Leu Tyr Met Ala Ser Pro Ser Asn Tyr Ser Thr Val

1 5 10 15

Pro Val Ser Glu Phe Leu Leu Ile Cys Phe Pro Asn Tyr Gln Ser Trp

Page 3889

069269_0225_SL.TXT 25 30

Gln His Trp 35 Leu Ser Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met 40 45 Gly Ala Asn Ala Thr Leu Leu Leu Thr Ile Gln Leu Glu Ala Ser Leu 50 55 60 His Glu Pro Met Tyr Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile 65 70 75 80 Val Leu Cys Leu Thr Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe 85 90 95 Asp Leu Arg Ser Ile Ser Phe Ser Ala Cys Phe Leu Gln Met Phe Ile 100 105 110 Met Asn Ser Phe Leu Thr Met Glu Ser Cys Thr Phe Met Val Met Ala 115 120 125 Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile 130 135 140 Ile Thr Asp His Phe Val Val Arg Ala Thr Ile Phe Val Val Ala Arg 145 150 155 160 Asn Gly Leu Phe Ser Leu Pro Val Pro Val Leu Ser Ser Arg Leu Thr 165 170 175 Tyr Cys Ala Glu Asn Thr Ile Lys Asn Cys Ile Cys Thr Asn Leu Ser 180 185 190 Val Ser Lys Leu Ser Cys Asp Asp Ile Thr Phe Asn Arg Leu Tyr Gln 195 200 205 Phe Val Ala Gly Trp Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Val 210 215 220 Leu Ser Tyr Ser Phe Ile Leu Lys Ala Val Leu Arg Ile Lys Ala Glu

Page 3890

0 6926 9_02 25_S L.TX T 225 230 235 240 Gly Ala Ala Ala Lys Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu 245 250 255 Ile Leu Phe Phe Ser Thr Val Leu Leu Val Leu Val Ile Thr Asn Leu 260 265 270 Ala Arg Lys Arg Ile Pro Pro Asp Val Pro Ile Leu Leu Asn Ile Leu 275 280 285 His His Leu Ile Pro Pro Ala Leu Asn Pro Ile Val Tyr Gly Val Arg 290 295 300 Thr Lys Glu Ile Lys Gln Gly Ile Gln Lys Leu Leu Arg Arg Leu 305 310 315

<210> 3477 <211> 943 <212> DNA <213> Felis catus <400> 3477

cacactttct tcagtaatct ctggattcct tgcttgatct cctgggttcg cactccatac 60 acaacggggt tgagggctga gaagatgata tggtggagga cgttgagcag gactggaaca 120 tcaggcgaga ccttcttctt caccacatga gtgagcacga agaccagaag gatggtgctg 180 aagaagagga taaggatgaa gtgggagcca catgtgctca gggccttggc cacagcaccc 240 tctgccttga gtctcagcac agctcgcaat atgagggtgt aggagaggaa gatgaggatg 300 aggtcagatc ctagcagtgt ccagcctgca acaaactggt agatgcgact aatggtgaca 360 tcattacaag agagcctgga gacaaacata ttggcacaga tgcaattgtc aatgacattt 420 gtcccacaat aatggagttg ggatgataga atggggatag gcattgtaac aatactattc 480 ctggccaaaa taaaaatggc agccttgact acaaattggt cagtgatgat ggatgggtac 540 ctcagtgggt ggcagatggc cacatagcgg tcataggcca tgaccatgaa tgtacaggat 600 tccatagcaa agaaccaatt catgatgtac atctggagga agcaggcata gaaactgatg 660 gacttgaggt caaaccagaa gatggccagg acctggggat gacagtgagg cagacaacaa 720

Page 3891

069269_0225_SL.TXT tgtccagcag ggaaaggata ctgagcaggt agtacatggg ctcatgcaga gagacctcta gccagatggt aatcaggaga acactattgg cccccatggc cagaaggaag agaaggctga ggggcaggga caaccagaac ttccagctgg gggacctgac aaaacaattc aggaggaagt ctgaaacctc agaggagatg gtgccatttt ggtatattgt cat

780

840

900

943 <210> 3478 <211> 211 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (211)..(211) <223> Any amino acid

<400> 3478 Trp Phe Phe Ala Met Glu Ser Cys Thr Phe Met Met 1 Tyr Ile Met Asn 5 10 15 Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro Leu Arg Tyr 20 25 30 Pro Ser Ile Ile Thr Asp Gln Phe Val Val Lys Ala Ala Ile Phe Ile 35 40 45 Leu Ala Arg Asn Ser Ile Val Thr Met Pro Ile Pro Ile Leu Ser Ser 50 55 60 Gln Leu His Tyr Cys Gly Thr Asn Val Ile Asp Asn Cys Ile Cys Ala 65 70 75 80 Asn Met Phe Val Ser Arg Leu Ser Cys Asn Asp Val Thr Ile Ser Arg 85 90 95 Ile Tyr Gln Phe Val Ala Gly Trp Thr Leu Leu Gly Ser Asp Leu Ile 100 105 110 Leu Ile Phe Leu Ser Tyr Thr Leu Ile Leu Arg Ala Val Leu Arg Leu 115 120 125

Page 3892

069269_0225_SL.TXT

Lys Ala Glu Gly Ala Val Ala Lys Ala Leu Ser Thr Cys Gly Ser His 130 135 140 Phe Ile Leu Ile Leu Phe Phe Ser Thr Ile Leu Leu Val Phe Val Leu 145 150 155 160 Thr His Val Val Lys Lys Lys Val Ser Pro Asp Val Pro Val Leu Leu 165 170 175 Asn Val Leu His His Ile Ile Phe Ser Ala Leu Asn Pro Val Val Tyr 180 185 190 Gly Val Arg Thr Gln Glu Ile Lys Gln Gly Ile Gln Arg Leu Leu Lys 195 200 205

Lys Val Xaa 210 <210> 3479 <211> 962 <212> DNA <213> Felis catus <400> 3479

atgctgcctt agaacagcag ctccctctct attgaagtct cagacttcat cctgaattgc 60 tttgtcaggt cccccatctg gaagcattgg ttgtctctgc ccctcagcct cctcttcctc 120 ctggctatgg ggccagtgcc accctcctga tcaccatccg gatcaggatg gaggtctctt 180 ggcataagcc catgtactac ctgctcggcc tcctttccct gctggacatc atgctctgct 240 tgactgtcat ccccaaggtc ttggccatct tctggtttga ccacaggtcc atcagcttct 300 ctacctgctt cctccagatg ttcatcatga attccttcct gcccatggaa tcatgcacct 360 tcctggccat ggcctatgac tgctatgtgt ccatctgtaa gcctctctac tacccatcta 420 tcatcactga ccagtttgta ggaaaggctg ttctcttcat cttggcccgg aacacatttc 480 ttcctgcacc tattcccatc ctctctgccc agcatcatta ctgtggaaaa aatataattg 540 agaactgtat gtgtgccaat ctctcttgtg tccaagctct cctgtgataa cattgccttt 600

Page 3893

069269_0225_SL.TXT

aacagaattt accatttagt tgtggcctgg actcttctgg gctctgacct catcctcatc 660 attttctcct atactttcat cctatgagcc gttcttagac tcaagacaaa aggggcagct 720 gccaaagctc tgaacacttg tggctctcac ttcatcctca tcctcttctt cagtaccatc 780 ctgctggttt ttgttttcac ccacattgcc aagaaaaaag tttcccctga tatccctgtc 840 ttacttaatg tgttacacca tgtaattcct gcagctctca accccattgt ctatggggta 900 cgaatgcagg agattaaaga ggggattagg aaattgctga ggagggtgag agcagcaagt 960 aa 962 <210> 3480 <211> 35 <212> PRT <213> Felis catus <400> 3480 Thr Cys Cys Ser His Pro Pro Gln Gln Phe Pro Asn Pro Leu Phe Asn 1 5 10 15 Leu Leu His Ser Tyr Pro Ile Asp Asn Gly Val Glu Ser Cys Arg Asn 20 25 30 Tyr Met Val 35 <210> 3481 <211> 949 <212> DNA <213> Felis catus <400> 3481 atgacagtgc atcaaaatgg caccatctcc tttgagattt cagacttcct cctgaattgt 60 tttatcaggt cccccagctg gaagctctgg ttgtccctgc cactcagcct cctcctcctc 120 ctggctatgg gggccaatgg tattctcttg atcaccattc ggatggaggt ctctctacat 180 gagcccatgt actacctgct cagcctcctc tccctattgg acattgtgct ctgcctcacc 240 gtcatcccca agattctggc catcttctgg tttgacctca aatccatcag cttctatgcc 300 tgcttcctcc agatgtacat catgaattgc ttcttcggca tggagtcctg cacattcatg 360 gtcatggcct atgaccgcta tgtagccatc tgccacccac tgaggtactc atccatcatc 420

Page 3894

069269_0225_SL.TXT

actgaccatt ttgtagccaa ggctgccatt tttattttgg ccagaaatgc acttcttact 480 atattcattc ccatcctctc tgcccggctc cattattgtg gaaaaaatat aattgagaac 540 tgtatgtgtg ccaatctctc tgtgtccaag ctctcctgtg ataacattgg ctttaacaga 600 atttaccatt tagttgtggc ctggactcta ctgggctctg acctcattct catcatcttc 660 tcctatacct tcatcctacg agccgttctt agactcaaga caaaaggggc agctgccaaa 720 gctctgagca cttgtggctc tcacttcatc ctcatcctct tcttcagcac catcctgctg 780 gtttttgttt tcacccacat tgccaagaaa aaaatttccc ctgatatccc tgtcttactt 840 aatgtgttac accatgtaat tcctgcagct ctcaacccca ttgtctatgg ggtacgaact 900 caggagatta aagaggggat taggaaatta ctgaggaggg caagagaga 949

<210> 3482 <211> 317 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (317)..(317) <223> Any amino acid <400> 3482

Met Thr Val His Gln Asn Gly Thr Ile Ser Phe Glu Ile Ser Asp Phe 1 5 10 15

Leu Leu Asn Cys Phe Ile Arg Ser Pro Ser Trp Lys Leu Trp Leu Ser 20 25 30

Leu Pro Leu Ser Leu Leu Leu Leu Leu Ala Met Gly Ala Asn Gly Ile 35 40 45

Leu Leu Ile Thr Ile Arg Met Glu Val Ser Leu His Glu Pro Met Tyr 50 55 60

Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr 65 70 75 80

Page 3895

069269_0225_SL.TXT

Val Ile Pro Lys Ile 85 Leu Ala Ile Phe Trp Phe Asp Leu Lys Ser Ile 90 95 Ser Phe Tyr Ala Cys Phe Leu Gln Met Tyr Ile Met Asn Cys Phe Phe 100 105 110 Gly Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Ser Ser Ile Ile Thr Asp His Phe 130 135 140 Val Ala Lys Ala Ala Ile Phe Ile Leu Ala Arg Asn Ala Leu Leu Thr 145 150 155 160 Ile Phe Ile Pro Ile Leu Ser Ala Arg Leu His Tyr Cys Gly Lys Asn 165 170 175 Ile Ile Glu Asn Cys Met Cys Ala Asn Leu Ser Val Ser Lys Leu Ser 180 185 190 Cys Asp Asn Ile Gly Phe Asn Arg Ile Tyr His Leu Val Val Ala Trp 195 200 205 Thr Leu Leu Gly Ser Asp Leu Ile Leu Ile Ile Phe Ser Tyr Thr Phe 210 215 220 Ile Leu Arg Ala Val Leu Arg Leu Lys Thr Lys Gly Ala Ala Ala Lys 225 230 235 240 Ala Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser 245 250 255 Thr Ile Leu Leu Val Phe Val Phe Thr His Ile Ala Lys Lys Lys Ile 260 265 270 Ser Pro Asp Ile Pro Val Leu Leu Asn Val Leu His His Val Ile Pro 275 280 285

Page 3896

069269_0225_S L.TX T Ala Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Gln Glu Ile Lys 290 295 300 Glu Gly Ile Arg Lys Leu Leu Arg Arg Ala Arg Glu Xaa 305 310 315

<210> 3483 <211> 946 <212> DNA <213> Felis catus <400> 3483

atgacagcgc accaaaatgg caccatctcc tctgaggttt cagacttcct cctgaattgt 60 tttgcccggt cccctagctg gaaattctgg ttgtccctgc ccctcagcct cctctttctt 120 ttagccatgg gggccaatag tgttctcctg atcaccatcc ggctggaggc atctctgcat 180 gagccattgt actacctgct cagcctcctc tctctgttgg acatcattgt ctgcctcacc 240 gtcatcccca aggtgctggc tgtcttttgg tttgacctca agtccatcgg cttctatgcc 300 tgcttcctcc agatgtacat catgaactgc ttcctttcca tggagtcctg cacattcatg 360 gtcatggcct atgactgcta tgtagccatc tgccacccac tgaggtaccc atccatcatc 420 actgaccaat ttgtagtcaa ggctgctgtc tttattttgg ccaggaatgg cattttaaca 480 gtacctatcc ccattctatc atcccgactc cattattgta ggacaaatgt cattgagaac 540 tgcctctgcg ccatatgtct gtctccaggc tctcctgcaa tgatgtcacc atcaatcgcc 600 tctaccagtt tgtcgtagga tggaccctgc tagggtctga cctcatcctc atctttgtct 660 cctatacctt catactgcga gctgtgctga gactcaagga agagggtgct gtggccaagg 720 ccctgagcac atgtggctcc cacttcatcc ttatcctctt cttcagcacc atccttctgg 780 tcttcgtgct cactcttgtg gtgaagaaga aagtctcccc ggatgtgcca gtcttgctca 840 acatcctcca ccatgtcatt ttctcagccc tcaaccccat tgtgtatggg gtgcgaaccc 900 aggagatcaa gcaaggaatc cagagattac tgaagaaagt gtggta 946

<210> 3484 <211> 205 <212> PRT <213> Felis catus

Page 3897

069269_0225_SL.TXT

<400> 3484 Gln Asn Gly Thr Ile Ser Ser Glu Val Ser Asp 15 Phe Met 1 Thr Ala His 5 10 Leu Leu Asn Cys Phe Ala Arg Ser Pro Ser Trp Lys Phe Trp Leu Ser 20 25 30 Leu Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala Asn Ser Val 35 40 45 Leu Leu Ile Thr Ile Arg Leu Glu Ala Ser Leu His Glu Pro Leu Tyr 50 55 60 Tyr Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Ile Val Cys Leu Thr 65 70 75 80 Val Ile Pro Lys Val Leu Ala Val Phe Trp Phe Asp Leu Lys Ser Ile 85 90 95 Gly Phe Tyr Ala Cys Phe Leu Gln Met Tyr Ile Met Asn Cys Phe Leu 100 105 110 Ser Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Cys Tyr Val 115 120 125 Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asp Gln Phe 130 135 140 Val Val Lys Ala Ala Val Phe Ile Leu Ala Arg Asn Gly Ile Leu Thr 145 150 155 160 Val Pro Ile Pro Ile Leu Ser Ser Arg Leu His Tyr Cys Arg Thr Asn 165 170 175 Val Ile Glu Asn Cys Leu Cys Ala Ile Cys Leu Ser Pro Gly Ser Pro 180 185 190 Ala Met Met Ser Pro Ser Ile Ala Ser Thr Ser Leu Ser 195 200 205

Page 3898

069269_0225_SL.TXT <210> 3485 <211> 941 <212> DNA <213> Felis catus <400> 3485 atgacaactc atggaaatga ctccactagg atttcagact ttctcctgaa ttgttttgtc 60 aggtccccca gctggcagct ctggctgtcc ctgcccctca gcctcctatt cctcctggcc 120 atgggggcta acgttattct cctaatcacc atccggctgg aggtctctct acaccagccc 180 atgtactacc tgctcagtat tgtctccctg ctggacattg tgctctgcct gactgtcatc 240 cccaaagtcc tggccatctt ctggtttgac ctcaagtcca tcagtttcta tgcctgcttc 300 ctccagatgt acatcatgaa ttgcttcttt gccatggagt cctgcacatt catggtcatg 360 gcctatgacc gctatgtagc catctgccac ccactgaggt acccatccat catcactgac 420 caatttgtag tcaaggctgc tgtctttatt ttggccagga atgcacttct tactgtgtcc 480 attcccatcc tctctgcccg gctccattac tgtgggagaa atgtcattga gaattgcatc 540 tgtgccaata tgtctgtctc caggctctcc tgtgatgatg tcaccatcaa tcgcctcctc 600 cagtttgctg gaggctggac actgctagga tccgacctca tcctcatcct cctctcctac 660 accctcatac tgcgagcggt gctgagactc aaggcagagg gtgctgtggc caaggccctg 720 agcacatgtg gctcccactt catccttatc ctcttcttca gcaccatcct tctggtcttc 780 gtgctcactc atgtggtgaa gaagaaggtc tcacccaatg tgccagtcct gctcaacgtc 840 ctccaccatg tcatccctgc agccctcaac cctatagttt atggagtgcg aacccaggag 900 atcaagcaag gaatccagag attactgaag aaagggtggt a 941 <210> 3486 <211> 314 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (314)..(314) <223> Any amino acid <400> 3486

Page 3899

069269_0225_SL.TXT

Met 1 Thr Thr His Gly 5 Asn Asp Ser Thr Arg Ile Ser Asp Phe Leu Leu 10 15 Asn Cys Phe Val Arg Ser Pro Ser Trp Gln Leu Trp Leu Ser Leu Pro 20 25 30 Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala Asn Val Ile Leu Leu 35 40 45 Ile Thr Ile Arg Leu Glu Val Ser Leu His Gln Pro Met Tyr Tyr Leu 50 55 60 Leu Ser Ile Val Ser Leu Leu Asp Ile Val Leu Cys Leu Thr Val Ile 65 70 75 80 Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Lys Ser Ile Ser Phe 85 90 95 Tyr Ala Cys Phe Leu Gln Met Tyr Ile Met Asn Cys Phe Phe Ala Met 100 105 110 Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asp Gln Phe Val Val 130 135 140 Lys Ala Ala Val Phe Ile Leu Ala Arg Asn Ala Leu Leu Thr Val Ser 145 150 155 160 Ile Pro Ile Leu Ser Ala Arg Leu His Tyr Cys Gly Arg Asn Val Ile 165 170 175 Glu Asn Cys Ile Cys Ala Asn Met Ser Val Ser Arg Leu Ser Cys Asp 180 185 190 Asp Val Thr Ile Asn Arg Leu Leu Gln Phe Ala Gly Gly Trp Thr Leu 195 200 205

Page 3900

Leu Gly 210 Ser Asp Leu Ile Leu 215 069269_0225_SL.TXT Ile Leu Leu Ser Tyr Thr 220 Leu Ile Leu Arg Ala Val Leu Arg Leu Lys Ala Glu Gly Ala Val Ala Lys Ala Leu 225 230 235 240 Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr Ile 245 250 255 Leu Leu Val Phe Val Leu Thr His Val Val Lys Lys Lys Val Ser Pro 260 265 270 Asn Val Pro Val Leu Leu Asn Val Leu His His Val Ile Pro Ala Ala 275 280 285 Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Gln Glu Ile Lys Gln Gly 290 295 300 Ile Gln Arg Leu Leu Lys Lys Gly Trp Xaa 305 310

<210> 3487 <211> 690 <212> DNA <213> Felis catus <400> 3487 gtacttgaat agtttgagaa taccttgctt gatttcctgg gttcgtactc cataaacaat 60 ggggttcagg gctggtggaa tgaggtggtg caagacattg agaagaatgg gtacctctga 120 gggcaccttc ttttctgcct tgtttgtgaa gatgaagaca agcagcaatg tatagaagaa 180 aagtataaga atgagatggg aaccacaagt actcaaggct ttggttgctg cacctcctga 240 ctgcagacgt ttaacagccc tcaggatgaa gcagtaggat agtaagatga gcactaggtc 300 agaacccagt agacaccaaa cactcacaaa ttggtagagc ttatttgggt gaatatcccc 360 acaggagagc tttgctacag aaatgttggc acagatacag ttctccacca cattgctggc 420 acagtagttg agcctggcag ccagaactgg tgtgggtagt gtggccacaa aattgcggaa 480 gacaatgaag atggctgcat aaatgacaaa tttttcagtg atggtggatg ggtagtgcag 540

Page 3901

069269_0225_SL.TXT aggatggcaa atggccacat agcggtcata ggccatgacc aggaaggtgg aagactccat aggaaggaat gtattcatga tgaacatctg cagaaagcag cctgcaaggc tgatggtctt catgttgaac cagaagatga gcaggacctg

600

660

690 <210> 3488 <211> 230 <212> PRT <213> Felis catus <400> 3488

Gln Val 1 Leu Leu Ile Phe Trp Phe Asn Met Lys Thr Ile Ser Leu 15 Ala 5 10 Gly Cys Phe Leu Gln Met Phe Ile Met Asn Thr Phe Leu Pro Met Glu 20 25 30 Ser Ser Thr Phe Leu Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 35 40 45 His Pro Leu His Tyr Pro Ser Thr Ile Thr Glu Lys Phe Val Ile Tyr 50 55 60 Ala Ala Ile Phe Ile Val Phe Arg Asn Phe Val Ala Thr Leu Pro Thr 65 70 75 80 Pro Val Leu Ala Ala Arg Leu Asn Tyr Cys Ala Ser Asn Val Val Glu 85 90 95 Asn Cys Ile Cys Ala Asn Ile Ser Val Ala Lys Leu Ser Cys Gly Asp 100 105 110 Ile His Pro Asn Lys Leu Tyr Gln Phe Val Ser Val Trp Cys Leu Leu 115 120 125 Gly Ser Asp Leu Val Leu Ile Leu Leu Ser Tyr Cys Phe Ile Leu Arg 130 135 140 Ala Val Lys Arg Leu Gln Ser Gly Gly Ala Ala Thr Lys Ala Leu Ser 145 150 155 160

Page 3902

069269_0225_SL.TXT

Thr Cys Gly Ser His 165 Leu Ile Leu Ile Leu Phe Phe Tyr Thr Leu Leu 170 175 Leu Val Phe Ile Phe Thr Asn Lys Ala Glu Lys Lys Val Pro Ser Glu 180 185 190 Val Pro Ile Leu Leu Asn Val Leu His His Leu Ile Pro Pro Ala Leu 195 200 205 Asn Pro Ile Val Tyr Gly Val Arg Thr Gln Glu Ile Lys Gln Gly Ile 210 215 220 Leu Lys Leu Phe Lys Tyr

225 230 <210> 3489 <211> 955 <212> DNA <213> Felis catus <400> 3489

ttacaacctt ctcagtagtt tctggattcc ctgcttgatc tctttggtcc tcacaccata 60 aacaatgggg ttcagagctg gggggatgag gtggtgcagg atgttgagca ggatggggac 120 atctggggga attctcttcc tggccaggtt agtgatgacc agaaccagca ggacagtgct 180 gaagaagagg atgaggatga agtgggaacc gcacgtgctc agggccttgg ccgcagcacc 240 ctcagccttg atccttagca cagctttcag gatgaaggag taggagagaa caataaggat 300 gaggtcagag cccaggaggg tccagcctgc cacaaactgg tagagccggt tgaaggtgat 360 gtcatcacaa gagagtttgg acacagacag gttagtgcag atgcagttct tgatgatgtt 420 ccctgcacaa tatctgagtc gggaagaaag gactggaaca ggaaggaaaa agaggccatt 480 ccgggccaca acaaatatgg tagctctaac cacaaaacgg tcggtgatta tggatgggta 540 tcgtagtggg tggcaaatgg ccacatagcg gtcataggcc atgaccatga atgtgcagga 600 ctccatggca aggaagcaat tcatgatgaa catctggagg aagcaggcag aaaagctgat 660 ggacctgagg tcaaaccaga agatggccag gaccttgggg atgacagtca ggcagagcac 720 gatgtccagc agggagagga ggctgagcag gtagtacatg ggctcgtgca gagaggcctc 780

Page 3903

069269_0225_SL.TXT cagctggatg gtgagcagga gggtggcgtt ggcccccatg gccaggagga aaaggaggct gaggggcaga gacaaccaat gctgccaact ctggtagtta ggaaagcaga tgaggaggaa ttcggagact ggagcagtgg agtagttgct gggtgaggcc atgtaaagtg ctctg

840

900

955 <210> 3490 <211> 313 <212> PRT <213> Felis catus

<400> 3490 Asn Tyr Ser Thr Ala Pro Val Ser Glu Phe Leu Met Ala 1 Ser Pro Ser 5 10 15 Leu Ile Cys Phe Pro Asn Tyr Gln Ser Trp Gln His Trp Leu Ser Leu 20 25 30 Pro Leu Ser Leu Leu Phe Leu Leu Ala Met Gly Ala Asn Ala Thr Leu 35 40 45 Leu Leu Thr Ile Gln Leu Glu Ala Ser Leu His Glu Pro Met Tyr Tyr 50 55 60 Leu Leu Ser Leu Leu Ser Leu Leu Asp Ile Val Leu Cys Leu Thr Val 65 70 75 80 Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Arg Ser Ile Ser 85 90 95 Phe Ser Ala Cys Phe Leu Gln Met Phe Ile Met Asn Cys Phe Leu Ala 100 105 110 Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg Tyr Val Ala 115 120 125 Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asp Arg Phe Val 130 135 140 Val Arg Ala Thr Ile Phe Val Val Ala Arg Asn Gly Leu Phe Phe Leu 145 150 155 160

Page 3904

069269_0225_SL.TXT

Pro Val Pro Val Leu Ser Ser Arg Leu Arg Tyr Cys Ala Gly Asn Ile 165 170 175 Ile Lys Asn Cys Ile Cys Thr Asn Leu Ser Val Ser Lys Leu Ser Cys 180 185 190 Asp Asp Ile Thr Phe Asn Arg Leu Tyr Gln Phe Val Ala Gly Trp Thr 195 200 205 Leu Leu Gly Ser Asp Leu Ile Leu Ile Val Leu Ser Tyr Ser Phe Ile 210 215 220 Leu Lys Ala Val Leu Arg Ile Lys Ala Glu Gly Ala Ala Ala Lys Ala 225 230 235 240 Leu Ser Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe Phe Ser Thr 245 250 255 Val Leu Leu Val Leu Val Ile Thr Asn Leu Ala Arg Lys Arg Ile Pro 260 265 270 Pro Asp Val Pro Ile Leu Leu Asn Ile Leu His His Leu Ile Pro Pro 275 280 285 Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Lys Glu Ile Lys Gln 290 295 300 Gly Ile Gln Lys Leu Leu Arg Arg Leu

305 310 <210> 3491 <211> 942 <212> DNA <213> Felis catus <400> 3491 tcacatccct gtccccatca atttcttaat tccttgtttt atctctttga tctgaacctc ataaacaata gggttcaagg cagggggtat gaggtgatga aggacattga gcaggatgag

120

Page 3905

069269_0225_SL.TXT gatgtctatg gctgatgaac cccctcagcc gaaatctgag actgtcacag ttcccacagt atttcatgtg atattgtagt ggactccatg gatggacctg atgatgtcca tccagccaga ctgaggggca aattgagact gggaccctat aggatgagga ttgaacctaa cctattaatg gagagcctgg aatggagctg attatgaaga gggtggcaga gggaggaagc aggtcaaaca gcagggagag tagtggtcaa gggacagcca ggagcagtgg ttctggccat tgaaatgaga gcacagctct tccaaccagc acacagacaa ggaagagaga aattagcctt tggccatgta tgttcatgat gaagatggcc caggctgagc cagggtggtg gtgctgccaa agtagttgcc gtttgtcaac gtcacatgcg taagatgaag cacaaattgg gttggcacag ataggaatag ggccacaaat gcgatcatag aaacatctgg aggaccttgg aggcagtaca ttggccccca ctccggtagt gggtgaggcc accacaacca ttcaggtctt gtataggaga tagatgccgt attcagttct ataggtacag tggtcagtga gccataaccc aggaagcaga ggatgacagt tgggctcgtg tggccaggat tagggaagca at gcagaatggt tgacagcagc agatgaggat taagggtgaa caatgacatt tgagtagggc ttatggaagg tgaatgtgca cagaaaagct caggcagagc cagagatgcc aaaaaggagg aatgaggagg

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942 <210> 3492 <211> 105 <212> PRT <213> Felis catus

<400> 3492 Leu Gln Ser Gln Phe Leu Leu Trp 1 Pro His Pro Ala Thr 5 Thr Pro Leu 10 15 Ile Cys Phe Pro Asn Tyr Arg Ser Trp Gln His Trp Leu Ser Leu Pro 20 25 30 Leu Ser Leu Leu Phe Ile Leu Ala Met Gly Ala Asn Thr Thr Leu Leu 35 40 45 Thr Thr Ile Trp Leu Glu Ala Ser Leu His Glu Pro Met Tyr Cys Leu 50 55 60 Leu Ser Leu Leu Ser Leu Leu Asp Ile Met Leu Cys Leu Thr Val Ile Page 3906

06926 9_02 25_SL.TXT 65 70 75 80 Pro Lys Val Leu Ala Ile Phe Cys Leu Thr Ser Gly Pro Ser Ala Phe 85 90 95 Leu Ser Ala Ser Ser Arg Cys Leu Ser 100 105

<210> 3493 <211> 952 <212> DNA <213> Felis catus <400> 3493

tcagatccat ccttttaggg agaataccct gagtactcgc tggcggatct gctgagtctt 60 taccccatag acaacaggat tgagtgcagg tggcacgagg aggtagagtg tggccagaag 120 aacatggaca tgatggggta catggtggcc aaagcggtga gtgaggaagg agaatattcc 180 aggaacatag aagatcagga tgacacaaat gtgagaccca catgtgctaa aggccttaag 240 tcgggcctca ccccccggta ctttcagcac tgtctggagg atgaaagcat aggaaatacc 300 aatggccacg acatctagcc caaccacaag cagggccact gccaacccat aagctcggtt 360 cactgtggtt tctgagcagg caagtttcac cacagccata tgttcacaat aggcatggcc 420 tatgacagtg gcctggcaga agataagtct ccgcaacagg atagggaagg ggaggaggag 480 gagtaacccc cgtaccagca ctgccattcc aatgcgccct atgatccctg gatgcaagat 540 ggtggaatgg tgcagagggt gacaaatggc tacatagcga tccagagcca tggccacaag 600 tacacctgac tccatggaag agaacgcatg gatgaagaac atttgggtca ggcagacagt 660 gtacccaatc tcatgggcat gaaccaggag cactgcaagg gttttgggtg cagtggagga 720 cgccagcacc aggtcaatgc cagagagcat ggccagaaag aggtacatag gctggtgcaa 780 ggatgggtca gtccagatga taaagatgat ggtgacattg cccattacag caaagagata 840 aaggacactc agcggcattg ctatccagtg ctggctttcc tctaaaccgg ggatgcccat 900 caggaaaaaa gaaggctgca gtagcctcca gctggaatta ctaagggcca tc 952

<210> 3494 <211> 316

Page 3907

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 3494 Met 1 Ala Leu Ser Asn Ser Ser Trp 5 Arg Leu 10 Leu Gln Pro Ser Phe Phe 15 Leu Met Gly Ile Pro Gly Leu Glu Glu Ser Gln His Trp Ile Ala Met 20 25 30 Pro Leu Ser Val Leu Tyr Leu Phe Ala Val Met Gly Asn Val Thr Ile 35 40 45 Ile Phe Ile Ile Trp Thr Asp Pro Ser Leu His Gln Pro Met Tyr Leu 50 55 60 Phe Leu Ala Met Leu Ser Gly Ile Asp Leu Val Leu Ala Ser Ser Thr 65 70 75 80 Ala Pro Lys Thr Leu Ala Val Leu Leu Val His Ala His Glu Ile Gly 85 90 95 Tyr Thr Val Cys Leu Thr Gln Met Phe Phe Ile His Ala Phe Ser Ser 100 105 110 Met Glu Ser Gly Val Leu Val Ala Met Ala Leu Asp Arg Tyr Val Ala 115 120 125 Ile Cys His Pro Leu His His Ser Thr Ile Leu His Pro Gly Ile Ile 130 135 140 Gly Arg Ile Gly Met Ala Val Leu Val Arg Gly Leu Leu Leu Leu Leu 145 150 155 160 Pro Phe Pro Ile Leu Leu Arg Arg Leu Ile Phe Cys Gln Ala Thr Val 165 170 175 Ile Gly His Ala Tyr Cys Glu His Met Ala Val Val Lys Leu Ala Cys 180 185 190

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Ser Glu Thr Thr Val Asn Arg Ala Tyr Gly Leu Ala Val Ala Leu Leu 195 200 205 Val Val Gly Leu Asp Val Val Ala Ile Gly Ile Ser Tyr Ala Phe Ile 210 215 220 Leu Gln Thr Val Leu Lys Val Pro Gly Gly Glu Ala Arg Leu Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Ile Cys Val Ile Leu Ile Phe Tyr Val 245 250 255 Pro Gly Ile Phe Ser Phe Leu Thr His Arg Phe Gly His His Val Pro 260 265 270 His His Val His Val Leu Leu Ala Thr Leu Tyr Leu Leu Val Pro Pro 275 280 285 Ala Leu Asn Pro Val Val Tyr Gly Val Lys Thr Gln Gln Ile Arg Gln 290 295 300 Arg Val Leu Arg Val Phe Ser Leu Lys Gly Trp Ile

305 310 315 <210> 3495 <211> 963 <212> DNA <213> Felis catus <400> 3495

tcaggtggga tcaatctgct tggtcctcag ccttttaagc agctgctccc ggatctgctt 60 ggtcttgacc ccatagacaa tggggtccag tgcaggggga aagagcaagt agagattggc 120 aaggatgacc ttagcagcag aggctgtggg tgggccaaag cgctgcatga ctacagaaag 180 aaagcctggt ccatagaaga agaggatgac acagacatga gctgtacatg tgctgccagc 240 tttagcacgt gcctcaggtg aaggaaaatg aatcacggtc ctcacaatgt gcccataaga 300 gtaggcaata aaggccacat cccccacacc aagaaagatt gccacagcaa aggcatagag 360 gttatccaca gtggtggccc cacaggccag cttcactact gccatatgct cacagtaggt 420

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ataggcaatc gtgtgagagc cacagtagga cagccgacgg gccaagcttg gaaaggagat 480 ggtcaatccc acacctcgca gcactaccag gcctccaatc ttggcaacaa caaccggggt 540 aagaatggtt gcataatgta gtgggttaca gatggccacg aagcggtcca cggccatggc 600 caccagcact cctgactcca tagcagagaa tgcatggatg aagaacatct gggaaagaca 660 ggagtgggag ctgatagctg tagcaccaaa ccagaagatg gccagcatct tgggcagagt 720 agagagggag agaaccaggt caacaaagga gagcatggca agaaagaaaa acatgggctg 780 gtgaaggctg tgctctgtcc ggatgagaaa aagcaggaca ccattcccag tcactgccag 840 gaagaacata aagcaaaagg gaagtgagat ccaaatgtgg gcagcagtca gtcctgggat 900 gccagccaag aagaaggtat gtgggaagtg atgagaatta ttggaaagaa ttatggtgat 960

cat 963 <210> 3496 <211> 320 <212> PRT <213> Felis catus <400> 3496

Met Ile Thr Ile Ile Leu Ser Asn Asn Ser His His Phe Pro His Thr 1 5 10 15 Phe Phe Leu Ala Gly Ile Pro Gly Leu Thr Ala Ala His Ile Trp Ile 20 25 30 Ser Leu Pro Phe Cys Phe Met Phe Phe Leu Ala Val Thr Gly Asn Gly 35 40 45 Val Leu Leu Phe Leu Ile Arg Thr Glu His Ser Leu His Gln Pro Met 50 55 60 Phe Phe Phe Leu Ala Met Leu Ser Phe Val Asp Leu Val Leu Ser Leu 65 70 75 80 Ser Thr Leu Pro Lys Met Leu Ala Ile Phe Trp Phe Gly Ala Thr Ala 85 90 95 Ile Ser Ser His Ser Cys Leu Ser Gln Met Phe Phe Ile His Ala Phe Page 391 0

100

069269_0225_SL.TXT 105 110

Ser Ala Met 115 Glu Ser Gly Val Leu Val Ala Met Ala Val Asp Arg Phe 120 125 Val Ala Ile Cys Asn Pro Leu His Tyr Ala Thr Ile Leu Thr Pro Val 130 135 140 Val Val Ala Lys Ile Gly Gly Leu Val Val Leu Arg Gly Val Gly Leu 145 150 155 160 Thr Ile Ser Phe Pro Ser Leu Ala Arg Arg Leu Ser Tyr Cys Gly Ser 165 170 175 His Thr Ile Ala Tyr Thr Tyr Cys Glu His Met Ala Val Val Lys Leu 180 185 190 Ala Cys Gly Ala Thr Thr Val Asp Asn Leu Tyr Ala Phe Ala Val Ala 195 200 205 Ile Phe Leu Gly Val Gly Asp Val Ala Phe Ile Ala Tyr Ser Tyr Gly 210 215 220 His Ile Val Arg Thr Val Ile His Phe Pro Ser Pro Glu Ala Arg Ala 225 230 235 240 Lys Ala Gly Ser Thr Cys Thr Ala His Val Cys Val Ile Leu Phe Phe 245 250 255 Tyr Gly Pro Gly Phe Leu Ser Val Val Met Gln Arg Phe Gly Pro Pro 260 265 270 Thr Ala Ser Ala Ala Lys Val Ile Leu Ala Asn Leu Tyr Leu Leu Phe 275 280 285 Pro Pro Ala Leu Asp Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile 290 295 300 Arg Glu Gln Leu Leu Lys Arg Leu Arg Thr Lys Gln Ile Asp Pro Thr

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305

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069269_0225_SL.TXT

315 <210> 3497 <211> 896 <212> DNA <213> Felis catus <400> 3497

tggggctccc aggcattcat gggtggcagc actggctctc cctgcccctg gctctgctct 60 acttcttagc tctttgtgct aatctcctca tcatcattac catccaacat gaggccacgc 120 tgcatatgcc tatgtaccat tttctgggca tactggctgt tgtggacatg ggcctggcca 180 ccaccatcat gcccaagatc ctggctacct tctggtttga tgccaaggcc atcagcctcc 240 ctgagtgttt tgctcagatc tatgccatcc actgtttctt cttcatggaa tctggtatct 300 tcctctgcat ggcattggac agatatatag ccatctgtca cccccttcga tacctgtcta 360 tagtcactga cacttttgtg gtcaaaacca caggattcat ggtgctcagg aattgactgt 420 ttactatccc agttccaata ctgtctgccc agagacacta ttgctccaag aaagaaattg 480 accactgcct gtgctctaat ttgggggtca ccagtctagc ctgtaatgac atcactgtga 540 acaaatttta ccaactgatc ttagcatgga tcctgactgg gagtgatatg gctctggttt 600 tttcttccta tgtgttaatc cttcactctg tgctgaggtt gaactcacca gaagcaatat 660 caaagctctg gggacctgta gctcccacct cattctcaat ctcttcttct atacaggtat 720 caccgtgcta tctgtcacat accttgcaga gaaaaatacg cccctaatcc ctgtgctgct 780 taatgtactg cacaatgtca tcccccctgc actcaatccc atggtctatg cactcaggat 840 gcaagagctc agactgggct tccagagact gcttggactg agtgaagata tgtcca 896

<210> 3498 <211> 137 <212> PRT <213> Felis catus <400> 3498

Gly Leu Pro Gly Ile His Gly Trp Gln His Trp Leu Ser Leu Pro Leu 1 5 10 15 Ala Leu Leu Tyr Phe Leu Ala Leu Cys Ala Asn Leu Leu Ile Ile Ile

20 25 30

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Thr Ile Gln His Glu Ala 35 Thr Leu His Met Pro Met Tyr His Phe Leu 40 45 Gly Ile Leu Ala Val Val Asp Met Gly Leu Ala Thr Thr Ile Met Pro 50 55 60 Lys Ile Leu Ala Thr Phe Trp Phe Asp Ala Lys Ala Ile Ser Leu Pro 65 70 75 80 Glu Cys Phe Ala Gln Ile Tyr Ala Ile His Cys Phe Phe Phe Met Glu 85 90 95 Ser Gly Ile Phe Leu Cys Met Ala Leu Asp Arg Tyr Ile Ala Ile Cys 100 105 110 His Pro Leu Arg Tyr Leu Ser Ile Val Thr Asp Thr Phe Val Val Lys 115 120 125 Thr Thr Gly Phe Met Val Leu Arg Asn 130 135

<210> 3499 <211> 966 <212> DNA <213> Felis catus <400> 3499 atggatacca ccctgagtat aaccaatagc tcaaggcttc aagtgtctga gttcatcctg 60 gtggggctcc caggcattca tgagtggcag cactggctct ccctgcccct ggctctgctc 120 tacatcttag ctctcattgc caacatcctc atcttgatca ccatccaaca tgagccttcc 180 ctgcaccagc ccatgtatca gctccttggc atcttggcta tcgtggacat tggcctggct 240 accaccatca tgcccaagat cctggccatt ctctggtttg atgccaaggc catcagcctc 300 cacgagtgct ttgctcagat ctatgctatc catactttca tgtgcatgga gtcaggcatc 360 ttcctctgca tggctgtgga tagatatgta gccatttgct acccccttca gtactcctcc 420 ctagtcaatg aggcttctgt gaccaaagcc accctgtcca tggtgctcag gaatggcctg 480

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ttgaccatcc cactgcctgt actggctgcc cagcgacact actgctccag aaatgaaatt 540 gaccactgtc tgtgctctaa tttgggggtc actagtctgg cctgtgatga cgtcactatt 600 aacagagtat accagttggc cttggcatgg gttacacttg ggggtgacat gggtctggtc 660 tttgcttcct atgctttgat tgttcgctca gtgctgaggc tgaactccac tgaagcaaca 720 tcgaaggccc tgagtacctg cagctcccat ctcatcctca ttgtcttctt ctacacagcc 780 attattgtgc tgtctgtcac ccacctggca ggaagaaagg tccccttcat ccctgttctc 840 ttcaacgtgc tgcataatgt tatgccccca gcctttaacc ccatggtgta tgccctccgg 900 acccaggagc tgagagtggg cttccagagg gtgcttggtt tgggtgagaa tgtgtccagg 960

aagtga 966 <210> 3500 <211> 321 <212> PRT <213> Felis catus <400> 3500

Met Asp Thr Thr Leu Ser Ile Thr Asn Ser Ser Arg Leu Gln Val Ser 1 5 10 15 Glu Phe Ile Leu Val Gly Leu Pro Gly Ile His Glu Trp Gln His Trp 20 25 30 Leu Ser Leu Pro Leu Ala Leu Leu Tyr Ile Leu Ala Leu Ile Ala Asn 35 40 45 Ile Leu Ile Leu Ile Thr Ile Gln His Glu Pro Ser Leu His Gln Pro 50 55 60 Met Tyr Gln Leu Leu Gly Ile Leu Ala Ile Val Asp Ile Gly Leu Ala 65 70 75 80 Thr Thr Ile Met Pro Lys Ile Leu Ala Ile Leu Trp Phe Asp Ala Lys 85 90 95 Ala Ile Ser Leu His Glu Cys Phe Ala Gln Ile Tyr Ala Ile His Thr 100 105 110

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Phe Met Cys 115 Met Glu Ser Gly Ile Phe Leu Cys Met Ala Val Asp Arg 120 125 Tyr Val Ala Ile Cys Tyr Pro Leu Gln Tyr Ser Ser Leu Val Asn Glu 130 135 140 Ala Ser Val Thr Lys Ala Thr Leu Ser Met Val Leu Arg Asn Gly Leu 145 150 155 160 Leu Thr Ile Pro Leu Pro Val Leu Ala Ala Gln Arg His Tyr Cys Ser 165 170 175 Arg Asn Glu Ile Asp His Cys Leu Cys Ser Asn Leu Gly Val Thr Ser 180 185 190 Leu Ala Cys Asp Asp Val Thr Ile Asn Arg Val Tyr Gln Leu Ala Leu 195 200 205 Ala Trp Val Thr Leu Gly Gly Asp Met Gly Leu Val Phe Ala Ser Tyr 210 215 220 Ala Leu Ile Val Arg Ser Val Leu Arg Leu Asn Ser Thr Glu Ala Thr 225 230 235 240 Ser Lys Ala Leu Ser Thr Cys Ser Ser His Leu Ile Leu Ile Val Phe 245 250 255 Phe Tyr Thr Ala Ile Ile Val Leu Ser Val Thr His Leu Ala Gly Arg 260 265 270 Lys Val Pro Phe Ile Pro Val Leu Phe Asn Val Leu His Asn Val Met 275 280 285 Pro Pro Ala Phe Asn Pro Met Val Tyr Ala Leu Arg Thr Gln Glu Leu 290 295 300 Arg Val Gly Phe Gln Arg Val Leu Gly Leu Gly Glu Asn Val Ser Arg 305 310 315 320

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Lys <210> 3501 <211> 969 <212> DNA <213> Felis catus <400> 3501

ttagcccgga ggggaagcac agcaccaagt cctgatgtcg aagaaccggt gggctacacc 60 ctcccggatc tgcttagtct tcacaccata gacaatggga ttgagcattg gtggcaccac 120 cacataaaga ttggccagca gaatatggac atgtcgagga atgttatgtc caaagcggtg 180 ggtcaataat gtaaagaagg atggaacata aaacataagg atgacacaga ggtgggagcc 240 acaagtgcta agggccttgt gccgggcatc ctgggagggc aaacgaaaca cggctcggag 300 gatcagtgag taagacacag caattaggat cacatccacg atgaccatga caatgggcac 360 tgagaagcca taccagatgt taatggtgat gtcagcgcag gccaagcggg ccactccaat 420 atgctcacaa taggaatggg ggacaatgtt ggtccggcag aagggcagcc gcttcaataa 480 gaagatcact gggaagatga tgcagaagct tctggtgaca atggccagac caatccttcc 540 cacaacacgc catgttagca tggctgtata atgcaggggg acacagatgg ccacaaagcg 600 gtcaaaggcc atggctaaca ggatggctga ctcccccaca aacatcacat ggacaaagaa 660 aacttgggtg acacaggcat caaaggcaat gtcatgggca tggagccaaa agatggctag 720 agccttgggt acggtagtag tggacagcag gatgtccgtg atggccagca tggagagaaa 780 gaagtacatg ggctcatgaa gattacgttc tgtgatgatg accactacca ggatgctgtt 840 ccccacgatg gcagtgatat acatgaggca gaggggtatt gacagccaaa tgtggtaagc 900 ctcccatcca gggatgccca gtaggacaaa aactgcaggg tgaaagatgg taaagttggt 960

gtgagtcat 969 <210> 3502 <211> 322 <212> PRT <213> Felis catus <400> 3502

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Met 1 Thr His Thr Asn 5 Phe Thr 069269_0225_SL.TXT Ile Phe His Pro Ala Val 10 Phe Val 15 Leu Leu Gly Ile Pro Gly Trp Glu Ala Tyr His Ile Trp Leu Ser Ile Pro 20 25 30 Leu Cys Leu Met Tyr Ile Thr Ala Ile Val Gly Asn Ser Ile Leu Val 35 40 45 Val Val Ile Ile Thr Glu Arg Asn Leu His Glu Pro Met Tyr Phe Phe 50 55 60 Leu Ser Met Leu Ala Ile Thr Asp Ile Leu Leu Ser Thr Thr Thr Val 65 70 75 80 Pro Lys Ala Leu Ala Ile Phe Trp Leu His Ala His Asp Ile Ala Phe 85 90 95 Asp Ala Cys Val Thr Gln Val Phe Phe Val His Val Met Phe Val Gly 100 105 110 Glu Ser Ala Ile Leu Leu Ala Met Ala Phe Asp Arg Phe Val Ala Ile 115 120 125 Cys Val Pro Leu His Tyr Thr Ala Met Leu Thr Trp Arg Val Val Gly 130 135 140 Arg Ile Gly Leu Ala Ile Val Thr Arg Ser Phe Cys Ile Ile Phe Pro 145 150 155 160 Val Ile Phe Leu Leu Lys Arg Leu Pro Phe Cys Arg Thr Asn Ile Val 165 170 175 Pro His Ser Tyr Cys Glu His Ile Gly Val Ala Arg Leu Ala Cys Ala 180 185 190 Asp Ile Thr Ile Asn Ile Trp Tyr Gly Phe Ser Val Pro Ile Val Met 195 200 205

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Val Ile 210 Val Asp Val Ile Leu 215 069269_0225_SL.TXT Ile Ala Val Ser Tyr Ser 220 Leu Ile Leu Arg Ala Val Phe Arg Leu Pro Ser Gln Asp Ala Arg His Lys Ala Leu 225 230 235 240 Ser Thr Cys Gly Ser His Leu Cys Val Ile Leu Met Phe Tyr Val Pro 245 250 255 Ser Phe Phe Thr Leu Leu Thr His Arg Phe Gly His Asn Ile Pro Arg 260 265 270 His Val His Ile Leu Leu Ala Asn Leu Tyr Val Val Val Pro Pro Met 275 280 285 Leu Asn Pro Ile Val Tyr Gly Val Lys Thr Lys Gln Ile Arg Glu Gly 290 295 300 Val Ala His Arg Phe Phe Asp Ile Arg Thr Trp Cys Cys Ala Ser Pro 305 310 315 320

Pro Gly <210> 3503 <211> 963 <212> DNA <213> Felis catus <400> 3503 atggcagaag gtccacattc caactccacc ttcccacgcc caaccttctt catactgact ggcattccag ggctagggcc tgcccaggct tggctgacac tggtcttcgg gcccatgtat ctgttggccc tgctgggcaa tggagcactg ctgacattgg tgcagataga ttccacactg cagcagccca tgtttctact cctggccgca ctggcagcca cagacctggg cttagctaca tctatagccc cagggttgct tgctgtgctg tggcttggac cccggcctgt gccatacagt gcctgcctgg tccagatgtt ctttgttcat gcactgactg ctgtagaatc tggtgtactg ctggccatgg cctgtgatcg tgccgtggca gtagggcgtc cactgcacta ccctctccta

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gtcaccaaag cccgtgtagg ctatgcagtc ctggcactgg cactgaaagc tgtggctatt 480 gttgtgcctt tccctctgct ggtggcgcga tttgagcact tccaagccaa gaccatagac 540 catgcctact gtgcacacat ggcggtggta gaactggtgg tgggcaacac acgggccaac 600 aatttgtatg ggctagcgct ttcactggct gtgtctggta tagatatcct gggcatcact 660 ggctcttatg ggctcattgc tcatgctgtg ctgcggctgc ctacccagga ggcccgtgct 720 aaggcctttg gcacatgtag ttcccacata tgtgtcattc tggccttcta tgtacctggt 780 ctcttctcct acctcacaca tcgctttggt cgtcacactg tcccaaagcc cgtacacatc 840 cttctctcta atatttattt gctgctgcca cctgccctca acccactcat ctatggggtc 900 cgcaccaagc aaatcaggga ccgactcctg gaaatcttca cattcagaaa aagccagttc 960 taa 963 <210> 3504 <211> 320 <212> PRT <213> Felis catus <400> 3504 Met Ala Glu Gly Pro His Ser Asn Ser Thr Phe Pro Arg Pro Thr Phe 1 5 10 15 Phe Ile Leu Thr Gly Ile Pro Gly Leu Gly Pro Ala Gln Ala Trp Leu 20 25 30 Thr Leu Val Phe Gly Pro Met Tyr Leu Leu Ala Leu Leu Gly Asn Gly 35 40 45 Ala Leu Leu Thr Leu Val Gln Ile Asp Ser Thr Leu Gln Gln Pro Met 50 55 60 Phe Leu Leu Leu Ala Ala Leu Ala Ala Thr Asp Leu Gly Leu Ala Thr 65 70 75 80 Ser Ile Ala Pro Gly Leu Leu Ala Val Leu Trp Leu Gly Pro Arg Pro 85 90 95 Val Pro Tyr Ser Ala Cys Leu Val Gln Met Phe Phe Val His Ala Leu

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069269_0225_SL.TXT 105 110

Thr Ala Val 115 Glu Ser Gly Val Leu Leu Ala Met Ala Cys Asp Arg Ala 120 125 Val Ala Val Gly Arg Pro Leu His Tyr Pro Leu Leu Val Thr Lys Ala 130 135 140 Arg Val Gly Tyr Ala Val Leu Ala Leu Ala Leu Lys Ala Val Ala Ile 145 150 155 160 Val Val Pro Phe Pro Leu Leu Val Ala Arg Phe Glu His Phe Gln Ala 165 170 175 Lys Thr Ile Asp His Ala Tyr Cys Ala His Met Ala Val Val Glu Leu 180 185 190 Val Val Gly Asn Thr Arg Ala Asn Asn Leu Tyr Gly Leu Ala Leu Ser 195 200 205 Leu Ala Val Ser Gly Ile Asp Ile Leu Gly Ile Thr Gly Ser Tyr Gly 210 215 220 Leu Ile Ala His Ala Val Leu Arg Leu Pro Thr Gln Glu Ala Arg Ala 225 230 235 240 Lys Ala Phe Gly Thr Cys Ser Ser His Ile Cys Val Ile Leu Ala Phe 245 250 255 Tyr Val Pro Gly Leu Phe Ser Tyr Leu Thr His Arg Phe Gly Arg His 260 265 270 Thr Val Pro Lys Pro Val His Ile Leu Leu Ser Asn Ile Tyr Leu Leu 275 280 285 Leu Pro Pro Ala Leu Asn Pro Leu Ile Tyr Gly Val Arg Thr Lys Gln 290 295 300 Ile Arg Asp Arg Leu Leu Glu Ile Phe Thr Phe Arg Lys Ser Gln Phe

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305 310 315 320 <210> 3505 <211> 944 <212> DNA <213> Felis catus <400> 3505

atgggagaag gaaaccaaac ttctgtggct gaatttatct tgctgggact ttcacaggat 60 ccaaaggtcc agatcctgct gttctgtgtt ttccttacca tttaccttct ctctgtgttt 120 ggaaacctgc ttgtaataat cctcattcaa agtgactctc gacttcacac tcccatgtac 180 tttttcctca aaaacttgtc ctttgctgac ctctgtttct ctacaagcat tgttcctcag 240 atgttggtcc acttcctcgt aaaaaggaaa accatttcct ttgctggatg ctcactgcag 300 ataattgtct tccttttagc agggtgtaca gagtgtgcac ttctggcagt gatgtcctat 360 gaccgctatg tggctgtctg caagcccctg cattattcca ctgtcatgac ccagagggtt 420 tgtgtccagt tggccatagt gtcttggatc agtggggcat ttgtatgttc agtggacagt 480 gcatttacac tgtgtcttcc ctaccaggga cagaatataa ttaatcatta tttttgtgaa 540 cctcctgcac tcctgaagct ggcttcagca gacacctaca atgctgagat ggctctcttt 600 tcaatgggtg tgattatcct cttagcacct ctctccctca tccttgtctc ctactggcat 660 attatctcaa cagtgattca gatgcagtca gaggagggga ggctcaaggt cttttctacc 720 tgtggctctc atctcactgt tgtggttctc tactatggct ctggaatatt tgcctatatg 780 agacccaatt ccaagacaat gaatgaaaag gatcaggtcg tctctgtgtt ctattcagtt 840 atgacttcca tgttgaaccc cataatttat agcctgagga acaaggacgt gaagggtgct 900 ctcaggaggc tggttggaag atagtctgcc ttcagaggca gtga 944

<210> 3506 <211> 307 <212> PRT <213> Felis catus <400> 3506

Met Gly Glu Gly Asn Gln Thr Ser Val Ala Glu Phe Ile Leu Leu Gly 1 5 10 15

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Leu Ser Gln Asp 20 Pro Lys Val Gln Ile Leu Leu Phe Cys Val Phe Leu 25 30 Thr Ile Tyr Leu Leu Ser Val Phe Gly Asn Leu Leu Val Ile Ile Leu 35 40 45 Ile Gln Ser Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Lys 50 55 60 Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln 65 70 75 80 Met Leu Val His Phe Leu Val Lys Arg Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Ser Leu Gln Ile Ile Val Phe Leu Leu Ala Gly Cys Thr Glu Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Val Met Thr Gln Arg Val Cys Val Gln Leu 130 135 140 Ala Ile Val Ser Trp Ile Ser Gly Ala Phe Val Cys Ser Val Asp Ser 145 150 155 160 Ala Phe Thr Leu Cys Leu Pro Tyr Gln Gly Gln Asn Ile Ile Asn His 165 170 175 Tyr Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Ala Asp Thr 180 185 190 Tyr Asn Ala Glu Met Ala Leu Phe Ser Met Gly Val Ile Ile Leu Leu 195 200 205 Ala Pro Leu Ser Leu Ile Leu Val Ser Tyr Trp His Ile Ile Ser Thr 210 215 220

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Val Ile 225 Gln Met Gln Ser Glu Glu Gly Arg Leu Lys Val Phe Ser Thr 230 235 240 Cys Gly Ser His Leu Thr Val Val Val Leu Tyr Tyr Gly Ser Gly Ile 245 250 255 Phe Ala Tyr Met Arg Pro Asn Ser Lys Thr Met Asn Glu Lys Asp Gln 260 265 270 Val Val Ser Val Phe Tyr Ser Val Met Thr Ser Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Arg Leu 290 295 300 Val Gly Arg

305 <210> 3507 <211> 927 <212> DNA <213> Felis catus <400> 3507

atggagtact ggaactccac cctgggcagt ggctttatat tgatggggat tctgaaagac 60 agtgggtctc ctgaactgct ctgtgtcata atcacagtcc tgtacatgtt ggccctgacc 120 agcaatggcc tgctgctctt ggtcatcaca gtggattccc ggctccacgt gcccatgtac 180 ttcctgctcg ggcagctctc actcatggac ctcctcttca catctgttgt cactcccaag 240 gctctcatgg attttctgcg cagtgaaaac accatctcct ttgcgggctg tgcccttcag 300 atgttcctgg cattgatgct gggtggtgca gaggacctgc tactggcctt catggcctat 360 gatagatatg tggccatttg tcatcctctg aactacatgg tcttcatgag gccaagggtc 420 tgctggctca tggtggccac agcatggata ctggcatcct taagtgccat tgtttatacc 480 atgtatacca tgcagtatcc cttctgcaaa gcccggaaca tcaggcacct gctctgtgag 540 attccacctt tgctgaagtt ggcctgtgca gatacctcta gatatgaact gtttgtgtat 600 gtgatgggtg tgaccttcct gatgccccct ctccttgcaa tcatttcttc ctatgcacta 660

Page 3923

069269_0225_SL.TXT atcctgttta ctgtgcttca catgccctca aatgagggga ggcagaaagc cctagtcacc tgctcttccc atctgactgt ggttgggatg ttctatggag ctgccacatt catgtatgtc ttgcccagtt ccctccacag ccccaagcaa gacaacatca cctctgtttt ctacacggtt gtcactccag ccctgaaccc ccttatctac agcttgagga ataaggaagt catgggggct ttgaagagag tgctgggaaa atacatg

720

780

840

900

927 <210> 3508 <211> 309 <212> PRT <213> Felis catus <400> 3508

Met Glu Tyr Trp Asn Ser Thr Leu Gly Ser Gly Phe Ile Leu Met Gly 1 5 10 15

Ile Leu Lys Asp Ser Gly Ser Pro Glu Leu Leu Cys Val Ile Ile Thr 20 25 30

Val Leu Tyr Met Leu Ala Leu Thr Ser Asn Gly Leu Leu Leu Leu Val 35 40 45

Ile Thr Val Asp Ser Arg Leu His Val Pro Met Tyr Phe Leu Leu Gly 50 55 60

Gln Leu Ser Leu Met Asp Leu Leu Phe Thr Ser Val Val Thr Pro Lys 65 70 75 80

Ala Leu Met Asp Phe Leu Arg Ser Glu Asn Thr Ile Ser Phe Ala Gly 85 90 95

Cys Ala Leu Gln Met Phe Leu Ala Leu Met Leu Gly Gly Ala Glu Asp 100 105 110

Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125

Pro Leu Asn Tyr Met Val Phe Met Arg Pro Arg Val Cys Trp Leu Met 130 135 140

Page 3924

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Val Ala Thr Ala Trp Ile Leu Ala Ser Leu Ser Ala Ile Val Tyr Thr 145 150 155 160 Met Tyr Thr Met Gln Tyr 165 Pro Phe Cys Lys Ala Arg Asn 170 Ile Arg His 175 Leu Leu Cys Glu Ile Pro 180 Pro Leu Leu Lys Leu Ala Cys 185 Ala Asp Thr 190 Ser Arg Tyr Glu Leu Phe 195 Val Tyr 200 Val Met Gly Val Thr 205 Phe Leu Met Pro Pro 210 Leu Leu Ala Ile Ile Ser 215 Ser Tyr Ala Leu Ile 220 Leu Phe Thr Val Leu 225 His Met Pro Ser 230 Asn Glu Gly Arg Gln Lys Ala 235 Leu Val Thr 240 Cys Ser Ser His Leu Thr 245 Val Val Gly Met Phe Tyr Gly 250 Ala Ala Thr 255 Phe Met Tyr Val Leu Pro 260 Ser Ser Leu His Ser Pro Lys 265 Gln Asp Asn 270 Ile Thr Ser Val Phe Tyr 275 Thr Val 280 Val Thr Pro Ala Leu 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn 290 Leu Gly Lys Tyr Met 305 <210> 3509 <211> 931 <212> DNA <213> Felis catus <400> 3509 Lys Glu 295 Val Met Gly Ala Leu 300 Lys Arg Val aaaaagatta ttttgcagtc actctcctga gagccccttt gacatccttg tttctcagac 60

Page 3925

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tataaatgat cgggttcaac atgggtgtca ctgctgagta gaacacagag atcattttat 120 ccctttcatt cattatcttg gagtttggcc tcatataggc aaatattgct gagccataga 180 agaggacaac aacaatgaga tgggagccac aggtagagaa agccttgaat ctcccctccc 240 cagactgcat ttggatcaca gcggagataa tattccagta ggagacaagg atcaggcaga 300 caggagctag gaggatgacc acgcccattg caaagatggc catttctgtg ctataggtat 360 ttgtggaagc cagcttcagg agggcaggag gttcacaaaa aaagtggtta atgatattgt 420 tcccttggta gggcagacac agtgtgaatg tggtatccac tagagatact aacgctccac 480 tgacccagga ccctaaggcc agctggacac ataaccaatg cgtcatgata gaagagtagt 540 gcaagggctt acatacagcc acataccggt cataggacat caccgccagc agtgcacact 600 ctgtacaccc aaccagaagt aaaacaaata tttgagttga gcatccagca aaggaaatgg 660 ttttcctctt tgccaggaag tggactagca cctggggcac tgtggtggta gagaaacaga 720 gatcagcaaa ggacaagttt ctaaggaaaa agtacatggg tgtgtggagt ctggagtctg 780 tgtggatgag cacaatgata agcagatttc ccagtacagt cagcaggtag atgatcagaa 840 aaaggaagaa gagcaggagt tgtgtgtgtg gatcctgtga aaggcccagg aaaacaaatt 900 cagtcacgta ggtttggttt tcttctccca t 931

<210> 3510 <211> 307 <212> PRT <213> Felis catus <400> 3510

Met 1 Gly Glu Glu Asn Gln Thr Tyr Val Thr Glu Phe Val Phe Leu Gly 5 10 15 Leu Ser Gln Asp Pro His Thr Gln Leu Leu Leu Phe Phe Leu Phe Leu 20 25 30 Ile Ile Tyr Leu Leu Thr Val Leu Gly Asn Leu Leu Ile Ile Val Leu 35 40 45 Ile His Thr Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg

50 55 60

Page 3926

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Asn 65 Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Thr Thr Val Pro Gln 70 75 80 Val Leu Val His Phe Leu Ala Lys Arg Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Ser Thr Gln Ile Phe Val Leu Leu Leu Val Gly Cys Thr Glu Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Ser Ile Met Thr His Trp Leu Cys Val Gln Leu 130 135 140 Ala Leu Gly Ser Trp Val Ser Gly Ala Leu Val Ser Leu Val Asp Thr 145 150 155 160 Thr Phe Thr Leu Cys Leu Pro Tyr Gln Gly Asn Asn Ile Ile Asn His 165 170 175 Phe Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Thr Asn Thr 180 185 190 Tyr Ser Thr Glu Met Ala Ile Phe Ala Met Gly Val Val Ile Leu Leu 195 200 205 Ala Pro Val Cys Leu Ile Leu Val Ser Tyr Trp Asn Ile Ile Ser Ala 210 215 220 Val Ile Gln Met Gln Ser Gly Glu Gly Arg Phe Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Val Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Phe Ala Tyr Met Arg Pro Asn Ser Lys Ile Met Asn Glu Arg Asp Lys 260 265 270

Page 3927

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Met Ile Ser Val Phe Tyr Ser Ala Val Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Arg Val 290 295 300 Thr Ala Lys

305 <210> 3511 <211> 924 <212> DNA <213> Felis catus <400> 3511

ctatcttcca aatgctttcc taaatgcctc ctttacctcc ttgtttctca ggctgtaaat 60 gaatgggttc atcatggatg ttatgactga gtagaacaca gaaatcacct tatccccttc 120 atttaccttc ttggaatttg gacgcatgta ggtaaatata gttgagccgt agaagaagac 180 cacaacaatg agatgagaac cacaggtaga aaaggcctta agtctcccct tacctgactg 240 tatccgaatc acagtggaga taatattcca gtaggagaaa aggatgaggg agacagggcc 300 aaggagaatt actatgccca ttgccaagat ggccatctca gctttgtagg tttcttctga 360 agccaacttc aagagtgcag gaggttcaca aaaataatga ttaattatat tctgtccatg 420 gtatgagaga cataaagtaa atattgtgtc tactaaagac acaatggctc cactggccca 480 ggaccctatg atcagctgta cacacaccct ctgggtcatg agggtggagt agtgaagggg 540 cttacagaca gccacatagc ggtcatagga catcactgct aggagggaac tttctgtaca 600 cccagctact aggaaaaaaa tcatctgaat tgaacaccca gcaaaggaaa tggtctttct 660 caaatccagc aagtggaata gcatctgggg gatgactgtt gtagagaaac atagatcagt 720 aaacgacagg tttttaagga agaagtacat tggtgtatga agtcgagagt caatatgaat 780 tagcactatg atgagaaaat tcccacacag agtcagcagg tagatgatga gaaacactac 840 aaacagcagg atttgggtct gccaatctga agaaaggcct agcaagatga attcagtcag 900 ataggtttgg ttttctgtgc ccat 924

Page 3928

069269_0225_SL.TXT <210> 3512 <211> 307 <212> PRT <213> Felis catus

<400> 3512 Met 1 Gly Thr Glu Asn Gln 5 Thr Tyr Leu Thr 10 Glu Phe Ile Leu Leu 15 Gly Leu Ser Ser Asp Trp Gln Thr Gln Ile Leu Leu Phe Val Val Phe Leu 20 25 30 Ile Ile Tyr Leu Leu Thr Leu Cys Gly Asn Phe Leu Ile Ile Val Leu 35 40 45 Ile His Ile Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Lys 50 55 60 Asn Leu Ser Phe Thr Asp Leu Cys Phe Ser Thr Thr Val Ile Pro Gln 65 70 75 80 Met Leu Phe His Leu Leu Asp Leu Arg Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Ser Ile Gln Met Ile Phe Phe Leu Val Ala Gly Cys Thr Glu Ser 100 105 110 Ser Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Leu Met Thr Gln Arg Val Cys Val Gln Leu 130 135 140 Ile Ile Gly Ser Trp Ala Ser Gly Ala Ile Val Ser Leu Val Asp Thr 145 150 155 160 Ile Phe Thr Leu Cys Leu Ser Tyr His Gly Gln Asn Ile Ile Asn His 165 170 175 Tyr Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Glu Glu Thr

Page 3929

180

069269_0225_SL.TXT 185 190

Tyr Lys Ala Glu Met Ala Ile Leu Ala Met Gly Ile Val Ile Leu Leu 195 200 205

Gly Pro Val Ser Leu Ile Leu Phe Ser Tyr Trp Asn Ile Ile Ser Thr 210 215 220

Val Ile Arg Ile Gln Ser Gly Lys Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240

Cys Gly Ser His Leu Ile Val Val Val Phe Phe Tyr Gly Ser Thr Ile 245 250 255

Phe Thr Tyr Met Arg Pro Asn Ser Lys Lys Val Asn Glu Gly Asp Lys 260 265 270

Val Ile Ser Val Phe Tyr Ser Val Ile Thr Ser Met Met Asn Pro Phe 275 280 285

Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Glu Ala Phe Arg Lys Ala 290 295 300

Phe Gly Arg 305 <210> 3513 <211> 917 <212> DNA <213> Felis catus <400> 3513

cccagtactc tcctggaggc ttctattacc tccttctttc tcagactata gacaagaggg 60 ttcagtgttg gagtaatgat aatacaaaat agagagagaa tgttgtcctg ttggggacta 120 tggtagtaat tgggctggat gtacatcaac atggcagctc catagtacat tcctaccaca 180 gtcaggtgag aagagcatgt ggtgaggact ttcttccttc ccttacccga ggacatgtga 240 aggacagcaa ttaggacaaa cgtataagag gcaaggatag cagcaagggt aggcatgaga 300 aagatcacac ctatcacata taccatgagc tcatatatgg aggtatctgc acaggccaat 360

Page 3930

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ttcaacaagg gtgggatctc acagagtagg tgcctcattt tccgagacat acagaaagga 420 aagtgcatag tatatgaagt gagtatcaca gcattcagga atgccaggat ccaaggtgtg 480 gctattgtga gccagcatat ccttggcctc atgcggacca tgtagtgcaa aggatgaaaa 540 atagccacat acctgtcata ggccatgaac gccagtagta agtcctctgc acctcctgaa 600 gtgagaacta ctaacatctg aaaggtgccg ccttcaaagg agatggtgtt ctccccatgc 660 agataatcca caagcatttg gggagtaact gcagatgcaa acatcaagtc catgagagat 720 agctggctaa gtagaaggta cataggcaca tggagccagg aatccattat aatgaccaag 780 agcagcaggc cattgctggt cagggccaac atgtatagga cagcgattgt ggcaaaaagc 840 agtttgggaa ccccactgtc attcagagtc tccgctaatg tgaagtcatt tcccaaggtg 900 gagttccaga <210> 3514 <211> 306 <212> PRT <213> Felis <400> 3514 gctccat catus 917 Met Glu Leu Trp Asn Ser Thr Leu Gly Asn Asp Phe Thr Leu Ala Glu 1 5 10 15 Thr Leu Asn Asp Ser Gly Val Pro Lys Leu Leu 20 25 Phe Ala Thr Ile Ala 30 Val Leu Tyr Met Leu Ala Leu Thr Ser Asn Gly Leu Leu Leu Leu Val 35 40 45 Ile Ile Met Asp Ser Trp Leu His Val Pro Met Tyr Leu Leu Leu Ser 50 55 60 Gln Leu Ser Leu Met Asp Leu Met Phe Ala Ser Ala Val Thr Pro Gln 65 70 75 80 Met Leu Val Asp Tyr Leu His Gly Glu Asn Thr 85 90 Ile Ser Phe Glu Gly 95

Page 3931

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Gly Thr Phe Gln Met Leu Val Val Leu Thr Ser Gly Gly Ala Glu Asp 100 105 110 Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Phe His 115 120 125 Pro Leu His Tyr Met Val Arg Met Arg Pro Arg Ile Cys Trp Leu Thr 130 135 140 Ile Ala Thr Pro Trp Ile Leu Ala Phe Leu Asn Ala Val Ile Leu Thr 145 150 155 160 Ser Tyr Thr Met His Phe Pro Phe Cys Met Ser Arg Lys Met Arg His 165 170 175 Leu Leu Cys Glu Ile Pro Pro Leu Leu Lys Leu Ala Cys Ala Asp Thr 180 185 190 Ser Ile Tyr Glu Leu Met Val Tyr Val Ile Gly Val Ile Phe Leu Met 195 200 205 Pro Thr Leu Ala Ala Ile Leu Ala Ser Tyr Thr Phe Val Leu Ile Ala 210 215 220 Val Leu His Met Ser Ser Gly Lys Gly Arg Lys Lys Val Leu Thr Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Gly Met Tyr Tyr Gly Ala Ala Met 245 250 255 Leu Met Tyr Ile Gln Pro Asn Tyr Tyr His Ser Pro Gln Gln Asp Asn 260 265 270 Ile Leu Ser Leu Phe Cys Ile Ile Ile Thr Pro Thr Leu Asn Pro Leu 275 280 285 Val Tyr Ser Leu Arg Lys Lys Glu Val Ile Glu Ala Ser Arg Arg Val 290 295 300

Page 3932

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Leu Gly

305 <210> 3515 <211> 957 <212> DNA <213> Felis catus <400> 3515 ttagcaaaga caatctctca agaaaagggc ttggccacta gacatggttt ttctgatggc 60 atctttgacc tccttgttcc tcaggcaata gataataggg ttgagcatgg gagtaaagac 120 tgcatatatg gctgagatca atttgttaga attgaatgaa gcaatggctc gaggtcggac 180 atacatgaag atcacagctg tatagaagat gaccaccact gtaaggtgag aggcacaggt 240 ggagaaggtc ttccactgcc cagtggctga gggaatgtgc aggatggtag agacaatgaa 300 gccataggaa aggacagtgg ctgagagggg aaacacaaga atgaaaatgg ctagcacaaa 360 gtctaccatc tcagccatag aaaaatccat gcaggccagt ttgaggatag gagaaacatc 420 acagaaaaaa tggttcaaga tattattgcc acagaaggca actcgggaga tgaagtatac 480 ctttgccatg gagatggtga agccactcac ccaggaactg atggtcagct gaacgcaaaa 540 tcctgtggtc atcatggctg gataacgaag aggacaacat atagccacgt aacggtcata 600 ggccatggca gccaagagca cacattcagt acaggcaagt gagatgaaga aatagagttg 660 gatcatgcat cccaggaagg agatggtatt gggacgaagt aggaatccag ccaacatctt 720 agggactgtg acagatacat accaagtctc cagaaaggac atggtgccca gaaaatagta 780 cataggcttg tgcagggacc cagtaaccca tacagtgaga atgataacca aattctccag 840 cagcacaaac aggtaggtga tgaggaagac aaggaaaagc agaacctgta gccaagggga 900 agtatggaag cccaccagga tgaattcact aacataggtg gtattttcct ttgacat 957 <210> 3516 <211> 318 <212> PRT <213> Felis catus <400> 3516

Met Ser Lys Glu Asn Thr Thr Tyr Val Ser Glu Phe Ile Leu Val Gly 1 5 10 15

Page 3933

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Phe His Thr Ser 20 Pro Trp Leu Gln Val Leu Leu Phe Leu Val Phe Leu 25 30 Ile Thr Tyr Leu Phe Val Leu Leu Glu Asn Leu Val Ile Ile Leu Thr 35 40 45 Val Trp Val Thr Gly Ser Leu His Lys Pro Met Tyr Tyr Phe Leu Gly 50 55 60 Thr Met Ser Phe Leu Glu Thr Trp Tyr Val Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Ala Gly Phe Leu Leu Arg Pro Asn Thr Ile Ser Phe Leu Gly 85 90 95 Cys Met Ile Gln Leu Tyr Phe Phe Ile Ser Leu Ala Cys Thr Glu Cys 100 105 110 Val Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Cys 115 120 125 Pro Leu Arg Tyr Pro Ala Met Met Thr Thr Gly Phe Cys Val Gln Leu 130 135 140 Thr Ile Ser Ser Trp Val Ser Gly Phe Thr Ile Ser Met Ala Lys Val 145 150 155 160 Tyr Phe Ile Ser Arg Val Ala Phe Cys Gly Asn Asn Ile Leu Asn His 165 170 175 Phe Phe Cys Asp Val Ser Pro Ile Leu Lys Leu Ala Cys Met Asp Phe 180 185 190 Ser Met Ala Glu Met Val Asp Phe Val Leu Ala Ile Phe Ile Leu Val 195 200 205 Phe Pro Leu Ser Ala Thr Val Leu Ser Tyr Gly Phe Ile Val Ser Thr 210 215 220

Page 3934

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Ile 225 Leu His Ile Pro Ser Ala Thr Gly Gln Trp Lys Thr Phe Ser Thr 230 235 240 Cys Ala Ser His Leu Thr Val Val Val Ile Phe Tyr Thr Ala Val Ile 245 250 255 Phe Met Tyr Val Arg Pro Arg Ala Ile Ala Ser Phe Asn Ser Asn Lys 260 265 270 Leu Ile Ser Ala Ile Tyr Ala Val Phe Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Cys Leu Arg Asn Lys Glu Val Lys Asp Ala Ile Arg Lys Thr 290 295 300 Met Ser Ser Gly Gln Ala Leu Phe Leu Arg Asp Cys Leu Cys 305 310 315

<210> 3517 <211> 945 <212> DNA <213> Felis catus <400> 3517

ttagctaagc aggaggcact gcccaacccc catggtcttt ttgacagcat tttttacttc 60 ctggtttcta aggcagtaga tgaagggatt tagcatgggt gtgaggactg catacacagc 120 tgagattagt ttgttggaat taaatgatgc aatagctctg ggccgaacat acataaaaat 180 catggctgta taataaatta tgaccacagt gaggtgggat gcacaggtgg agaaggcttt 240 cttccttccc tgggtggagg gtatccgcag aatggtggag acaatgtata cataggaaag 300 gacagtggtg atgagtggga agacaagaat gacaatagcc aaagcaaagt ccactagctc 360 agctgtggac atgtctttgc aagccagctt aaggattggt gagatatcac agaaaaagtg 420 gttcatgaca ttagaaccac aaaaggcaac atgtgaaatg aaataaactt tgatgacaga 480 gaccatgaaa ccacttacat aggagaacgc cactagctgt acacaacaac ctgtggtcat 540 aatgactggg tattggagag ggtggcaaat ggccacatag cggtcatagg ccatggttgc 600 cagaagcaca cactctgtgc aggcgagcga gataaagaag tagagctggg tcatgcaacc 660

Page 3935

069269_0225_SL.TXT tgtgaaggag atgcgccgtt agagacatac cagacctcca gagggagcca gtgatccaaa gtagaccaca aggaagagga caccaagatg aattcactga tctgcaaaag gaatccatcc gaaaggacaa gctactcagg cagtgagcat gatgataaga agaagagcag gacttgtagc ccagagtgat gtttttcccc agcatcttgg ggactgtgac aaatagtaca tgggcttatg ttctctatta tcaccagcaa catggggcag tggggaagcc agcat

720

780

840

900

945 <210> 3518 <211> 314 <212> PRT <213> Felis catus

<400> 3518 Met 1 Leu Gly Lys Asn Ile 5 Phe Pro Thr Ala 20 Pro Trp Val Val Tyr 35 Leu Leu Val Val Trp 50 Ile Thr Gly Ser Ser 65 Leu Ser Phe Leu Glu 70 Met Leu Asp Gly Phe 85 Leu Cys Met Thr Gln 100 Leu Tyr Val Leu Leu 115 Ala Thr Met Pro Leu 130 Gln Tyr Pro Val

Thr Leu Val Ser 10 Glu Leu Gln Val 25 Leu Leu Ile Ile 40 Glu Asn Leu Leu 55 His Lys Pro Met Val Trp Tyr Val Ser 75 Leu Gln Lys Arg 90 Arg Phe Phe Ile 105 Ser Leu Ala Tyr 120 Asp Arg Tyr Ile 135 Met Thr Thr Gly

Phe Ile Leu Val 15 Gly Phe Phe Leu 30 Phe Leu Ile Ile 45 Met Leu Thr Tyr 60 Tyr Phe Leu Ser Val Thr Val Pro Lys 80 Ile Ser Phe Thr 95 Gly Ala Cys Thr 110 Glu Cys Val Ala 125 Ile Cys His Cys 140 Cys Val Gln Leu

Page 3936

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Val Ala Phe Ser Tyr Val Ser Gly Phe Met Val Ser Val Ile Lys Val 145 150 155 160 Tyr Phe Ile Ser His Val Ala Phe Cys Gly Ser Asn Val Met Asn His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Ile Leu Lys Leu Ala Cys Lys Asp Met 180 185 190 Ser Thr Ala Glu Leu Val Asp Phe Ala Leu Ala Ile Val Ile Leu Val 195 200 205 Phe Pro Leu Ile Thr Thr Val Leu Ser Tyr Val Tyr Ile Val Ser Thr 210 215 220 Ile Leu Arg Ile Pro Ser Thr Gln Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ile Ile Tyr Tyr Thr Ala Met Ile 245 250 255 Phe Met Tyr Val Arg Pro Arg Ala Ile Ala Ser Phe Asn Ser Asn Lys 260 265 270 Leu Ile Ser Ala Val Tyr Ala Val Leu Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Cys Leu Arg Asn Gln Glu Val Lys Asn Ala Val Lys Lys Thr 290 295 300 Met Gly Val Gly Gln Cys Leu Leu Leu Ser 305 310

<210> 3519 <211> 954 <212> DNA <213> Felis catus <400> 3519

Page 3937

069269_0225_SL.TXT atggctgaag gaaaccagac aagggttggg gagtttatcc tcatgagctt ctcttcccta 60 cctactgaaa tacagtcact actcttcctg acatttctaa tcatctacct ggtcacgcta 120 ttgggaaaca gcctcatcat tcttgttacc ttgactgacc ccatgctgca cagccccatg 180 tacttcttcc tcaggaactt gtccttcttg gagattggct tcaacctagt catcgtgccc 240 aagatgctgg ggaccctgct tgcccgggac acaaccatct ccttccttgg ctgtgccatg 300 cagatgtatt tcttcttctt ctttggagtt gctgaatgcg tcctcctggc cgccatggca 360 tatgaccgct atgtagccat ctgcaatccc ttgcactacc cagtcatcat gaaccagagg 420 acacgtgcca aattggctgt tgcctcctgg tttccaggct ttcccgtagc tactgtgcag 480 accacttggc tcttcagctt tccattctgt ggcaccaaca aggtgaacca cttcttctgt 540 gacagcccac ctgtgctgag actggtgtgt gcagacacag caatgtttga gatctatgcg 600 attgttggaa ctgtgctggt cgtcatgata ccctgcatgc tgatcctgtg ttcctacatt 660 cgcattgctg ctgccatcct taagattcca tcagctaaag ggaagcataa agccttctct 720 acctgctcct cccacctcct tgttgtctcc ctattctatg tatcttcaag cctcacctac 780 ttccggccta aatccaataa ttcgcctgag agcaaaaagc tgctgtcatt gtcctacact 840 gttgtgactc ccatgttgaa ccccatcatc tatagcctga gaaataatga ggtgaagaat 900 gcccttggcc ggaccttctg caaggctttc ggccttagaa tttgcatccc atag 954 <210> 3520 <211> 317 <212> PRT <213> Felis catus

<400> 3520 Met 1 Ala Glu Gly Asn Gln Thr Arg Val Gly Glu Phe Ile Leu Met Ser 5 10 15 Phe Ser Ser Leu Pro Thr Glu Ile Gln Ser Leu Leu Phe Leu Thr Phe 20 25 30 Leu Ile Ile Tyr Leu Val Thr Leu Leu Gly Asn Ser Leu Ile Ile Leu 35 40 45 Val Thr Leu Thr Asp Pro Met Leu His Ser Pro Met Tyr Phe Phe Leu Page 3938

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50 55 60

Arg 65 Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile Val Pro 70 75 80 Lys Met Leu Gly Thr Leu Leu Ala Arg Asp Thr Thr Ile Ser Phe Leu 85 90 95 Gly Cys Ala Met Gln Met Tyr Phe Phe Phe Phe Phe Gly Val Ala Glu 100 105 110 Cys Val Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu His Tyr Pro Val Ile Met Asn Gln Arg Thr Arg Ala Lys 130 135 140 Leu Ala Val Ala Ser Trp Phe Pro Gly Phe Pro Val Ala Thr Val Gln 145 150 155 160 Thr Thr Trp Leu Phe Ser Phe Pro Phe Cys Gly Thr Asn Lys Val Asn 165 170 175 His Phe Phe Cys Asp Ser Pro Pro Val Leu Arg Leu Val Cys Ala Asp 180 185 190 Thr Ala Met Phe Glu Ile Tyr Ala Ile Val Gly Thr Val Leu Val Val 195 200 205 Met Ile Pro Cys Met Leu Ile Leu Cys Ser Tyr Ile Arg Ile Ala Ala 210 215 220 Ala Ile Leu Lys Ile Pro Ser Ala Lys Gly Lys His Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Val Ser Ser 245 250 255 Ser Leu Thr Tyr Phe Arg Pro Lys Ser Asn Asn Ser Pro Glu Ser Lys

Page 3939

260

069269_0225_SL.TXT 265 270

Lys Leu Leu Ser Leu Ser Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285

Ile Ile Tyr Ser Leu Arg Asn Asn Glu Val Lys Asn Ala Leu Gly Arg 290 295 300

Thr Phe Cys Lys Ala Phe Gly Leu Arg Ile Cys Ile Pro 305 310 315 <210> 3521 <211> 970 <212> DNA <213> Felis catus <400> 3521 atgtcaatga aatcctggac agaagaatga ttgtccttgt gagtttttca accttatcct ttttgactgt ttacctggtt actctaatgg ctgactctgc tctacaaaac cctatgtact taggcttcaa cttggtcatt gtgcccaaga ccatatcctt ctttggctgt gcctctcaga agtgttgcct cctggccaca atggcatatg gctacccaat cattatgaac cgcaaggcct cagggtttcc agtggccacc gtgcaaacca ccaacatagt gaaccacttc ttttgtgaca atacctctct gtttgaactg gaggctctga tcttgctgat cctgggatcc tatgtccgca ctgaggggaa acgcaaggcc ttctccacct tctacagcac tgccatcctc acatacttcc agaagttgtt gtcgctctcc tacacagtag gcttaaggaa cagtgaagtg aagtctgcac tgtggggaaa ctgagctaca gcaatattct tcttcctcag tgctggggac tgtatttctt accgctatgt gtgcccagct catggatttt gcccccctgt cggccactgt ttctttccac gttcctccca gaccccggtc tgactcccat tgaggcgagt

ctggacaatt gtcagtgagt 60 agctctacta tttctccttt 120 catcatcctg gtcactacag 180 gaacttgtcc ttcctggaga 240 tctgatcatc caagacacaa 300 tttcttcttt ggggctgctg 360 ggccatctgt gaccctttgc 420 agcagctgcc tcttggttct 480 cagcttccct ttttgtggcc 540 cattgcactg gtctgtgctg 600 cttattcatc ctctttcctt 660 tatcttcagg atgccctcag 720 ccttctggtt gtgtccctct 780 cagcacctct cctgagagca 840 gttgaacccc atcatctaca 900 catccgcagg accctgggcc 960

Page 3940

069269_0225_SL.TXT ctcagaaact

970 <210> 3522 <211> 315 <212> PRT <213> Felis catus

<400> 3522 Met 1 Met Trp Gly Asn 5 Trp Thr Ile Val Ser Glu Phe Val Leu Val Ser 10 15 Phe Ser Thr Leu Ser Ser Glu Leu Gln Ala Leu Leu Phe Leu Leu Phe 20 25 30 Leu Thr Val Tyr Leu Val Thr Leu Met Gly Asn Ile Leu Ile Ile Leu 35 40 45 Val Thr Thr Ala Asp Ser Ala Leu Gln Asn Pro Met Tyr Phe Phe Leu 50 55 60 Arg Asn Leu Ser Phe Leu Glu Ile Gly Phe Asn Leu Val Ile Val Pro 65 70 75 80 Lys Met Leu Gly Thr Leu Ile Ile Gln Asp Thr Thr Ile Ser Phe Phe 85 90 95 Gly Cys Ala Ser Gln Met Tyr Phe Phe Phe Phe Phe Gly Ala Ala Glu 100 105 110 Cys Cys Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asp Pro Leu Arg Tyr Pro Ile Ile Met Asn Arg Lys Ala Cys Ala Gln 130 135 140 Leu Ala Ala Ala Ser Trp Phe Ser Gly Phe Pro Val Ala Thr Val Gln 145 150 155 160 Thr Thr Trp Ile Phe Ser Phe Pro Phe Cys Gly Pro Asn Ile Val Asn 165 170 175

Page 3941

069269_0225_SL.TXT

His Phe Phe Cys Asp Ser Pro Pro Val Ile Ala Leu Val Cys Ala Asp 180 185 190 Thr Ser Leu Phe Glu Leu Glu Ala Leu Thr Ala Thr Val Leu Phe Ile 195 200 205 Leu Phe Pro Phe Leu Leu Ile Leu Gly Ser Tyr Val Arg Ile Leu Ser 210 215 220 Thr Ile Phe Arg Met Pro Ser Ala Glu Gly Lys Arg Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ser His Leu Leu Val Val Ser Leu Phe Tyr Ser Thr Ala 245 250 255 Ile Leu Thr Tyr Phe Arg Pro Arg Ser Ser Thr Ser Pro Glu Ser Lys 260 265 270 Lys Leu Leu Ser Leu Ser Tyr Thr Val Val Thr Pro Met Leu Asn Pro 275 280 285 Ile Ile Tyr Ser Leu Arg Asn Ser Glu Val Lys Ser Ala Leu Arg Arg 290 295 300 Val Ile Arg Arg Thr Leu Gly Pro Gln Lys Leu

305 310 315 <210> 3523 <211> 948 <212> DNA <213> Felis catus <400> 3523 tcagtggaag atttcaagcc tgcatgagaa attccttgtg gctacttttc tcagagctcc cttcacgtcc ttgtttctca agctatagat gaggggatta agcataggtg tcaccactcc ataaaacaca gacaccagtt tttcctgttc tttggaagac tttggagtca tgtaagtgac aattgctgac ccataaaaaa ggatgaccac catgaggtgg gagccacagg tagagaatgc

120

180

240

Page 3942

069269_0225_SL.TXT cttgagcctc taccagaatt ctctgaagta atgagcaata agacaccaga catgatgcta tgccagaaag acgtgtgaat gttggtagaa gtgaagccgg gaggtagaca tcccagaagg cccacagctg agggaaacag tgagtgtctg ctattgctgc atgccgctgg gggtaatgca gcacactggg gaaatgacct aaacagaagt gagtcaacct cccaggaata aggaattctg acttcatcct gtatgaggag tggatgccag cttggtaggg tccatgatcc aagggttgca tgcacccaaa tcttctggga cagccagaga gaacaaggta aaatgaatag tcacctgtgt gaccacagtc aatcacaaca gatcaacagt taaacttagt tgcagccagc gatggccacg aatgaggaag tagcaggtgg taagttgcag cgtgagaagt caacttctgg ctgatttgtt actatgatgt cccatgagga gcaggggcct gtaaaagtgg tggacacaca taccgatcat aatagaagct gctagggcct aggaaaaaat agatttgcaa gtgtgtgggt tctctcat gactatagga aaatgaccat cacaaaagaa tatctaccac ccctccaagt aggacatcac gagttgcaca ggggaacgat acatgggttt gcacagtgat catcagaaag

300

360

420

480

540

600

660

720

780

840

900

948 <210> 3524 <211> 315 <212> PRT <213> Felis catus

<400> 3524 Gln Thr Gln Val Thr Glu Phe Leu Leu Leu Gly Met 1 Arg Glu Thr Asn 5 10 15 Leu Ser Asp Asp Pro His Thr Gln Lys Leu Leu Phe Ile Leu Phe Leu 20 25 30 Gly Val Tyr Leu Ile Thr Val Leu Ala Asn Leu Leu Leu Thr Tyr Leu 35 40 45 Val Gln Val Asp Ser Arg Leu His Lys Pro Met Tyr Phe Phe Leu Cys 50 55 60 Asn Leu Ser Leu Ala Asp Phe Cys Phe Ser Thr Asn Ile Val Pro Gln 65 70 75 80 Ala Leu Ala His Leu Leu Ser Gln Lys Lys Val Ile Ser Phe Thr Arg

Page 3943

069269_0225_SL.TXT

85 90 95 Cys Ala Thr Gln Leu Leu Phe Phe Leu Ile Phe Gly Cys Thr Gln Cys 100 105 110 Ala Phe Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu His Tyr Pro Ser Ile Met Thr Trp Arg Val Cys Val Gln Leu 130 135 140 Ala Ala Gly Ser Trp Thr Ser Gly Ile Leu Val Ser Val Val Asp Thr 145 150 155 160 Thr Phe Thr Leu Ser Leu Pro Tyr Gln Gly Ser Asn Ser Ile Ala His 165 170 175 Phe Phe Cys Glu Ala Pro Ala Leu Leu Ile Leu Ala Ser Thr Asp Thr 180 185 190 His Thr Ser Glu Met Val Ile Phe Leu Met Gly Val Val Ile Leu Leu 195 200 205 Ile Pro Val Ser Leu Ile Leu Val Ser Tyr Ser His Ile Ile Val Thr 210 215 220 Val Val Arg Met Lys Ser Ala Val Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Met Val Val Ile Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Val Thr Tyr Met Thr Pro Lys Ser Ser Lys Glu Gln Glu Lys Leu Val 260 265 270 Ser Val Phe Tyr Gly Val Val Thr Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Lys Val Ala Thr

Page 3944

069269_0225_SL.TXT 290 295 300

Arg Asn Phe Ser Cys Arg Leu Glu Ile Phe His 305 310 315

<210> 3525 <211> 945 <212> DNA <213> Felis catus <400> 3525

atgggcgagg aaaaccaaac ctctgtggct gagtttattt tctttggcct ttcacaggac 60 ttgaagaccg aaatcctgct atttactctt tttctcatca tttatctttt gactgtattt 120 ggaaacctgc tcatcatcat tctcatcttc atggattctc gacttcacac tcccatgtac 180 ttttttctta gaaacctctc tttcgcagat ctctgtttct ctactagcat tgtcccccaa 240 gtgttggtcc acttccttgt aaagaggaaa actatttctt tttttggatg tgtgacacag 300 ataattgtct tccttctggt tgggtgtaca gagtgcgcac tgctggcggt gatgtcttat 360 gaccggtatg tggctgtctg caagcccctg cactactcta ctatcatgac ccaccaggtg 420 tgtctccagt tggccatagg atcctgggcc agtggggcac tggtgtctct ggtggatacc 480 acctttactt tccaactacc ctatcaagga cagaacatta ttaatcacta cttttgtgaa 540 cctcctgccc tcctgaagct ggcttcagca gatacttata gcacagaaat ggccatcttt 600 gcaatgggcg tggtcatcct cttagctcct gtctgcctga tccttgtctc ctactggaat 660 attatctcca ctgtgatcca gatgcagtct ggggagggga ggctcaaggc tttctctacc 720 tgtggctccc atctcattgt tgtcatcctc ttctatgggt caggaatatt cacctacatg 780 cggccaaact ccaagaccac aaaagagcgg gataaaatga tatctgtgtt ctatacagtg 840 gtgacgccaa tgttgaaccc cataatttat agcctgagaa acaaggatgt caaaggggct 900 ctcaggaaac tagctggaag aaagtccttt tttcagaggc agtga 945

<210> 3526 <211> 314 <212> PRT <213> Felis catus <400> 3526

Page 3945

069269_0225_SL.TXT

Met 1 Gly Glu Glu Asn 5 Gln Thr Ser Val Ala Glu Phe Ile Phe Phe Gly 10 15 Leu Ser Gln Asp Leu Lys Thr Glu Ile Leu Leu Phe Thr Leu Phe Leu 20 25 30 Ile Ile Tyr Leu Leu Thr Val Phe Gly Asn Leu Leu Ile Ile Ile Leu 35 40 45 Ile Phe Met Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Arg 50 55 60 Asn Leu Ser Phe Ala Asp Leu Cys Phe Ser Thr Ser Ile Val Pro Gln 65 70 75 80 Val Leu Val His Phe Leu Val Lys Arg Lys Thr Ile Ser Phe Phe Gly 85 90 95 Cys Val Thr Gln Ile Ile Val Phe Leu Leu Val Gly Cys Thr Glu Cys 100 105 110 Ala Leu Leu Ala Val Met Ser Tyr Asp Arg Tyr Val Ala Val Cys Lys 115 120 125 Pro Leu His Tyr Ser Thr Ile Met Thr His Gln Val Cys Leu Gln Leu 130 135 140 Ala Ile Gly Ser Trp Ala Ser Gly Ala Leu Val Ser Leu Val Asp Thr 145 150 155 160 Thr Phe Thr Phe Gln Leu Pro Tyr Gln Gly Gln Asn Ile Ile Asn His 165 170 175 Tyr Phe Cys Glu Pro Pro Ala Leu Leu Lys Leu Ala Ser Ala Asp Thr 180 185 190 Tyr Ser Thr Glu Met Ala Ile Phe Ala Met Gly Val Val Ile Leu Leu 195 200 205

Page 3946

Ala Pro 210 Val Cys Leu Ile Leu 215 069269_0225_SL.TXT Val Ser Tyr Trp Asn Ile 220 Ile Ser Thr Val Ile Gln Met Gln Ser Gly Glu Gly Arg Leu Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ile Val Val Ile Leu Phe Tyr Gly Ser Gly Ile 245 250 255 Phe Thr Tyr Met Arg Pro Asn Ser Lys Thr Thr Lys Glu Arg Asp Lys 260 265 270 Met Ile Ser Val Phe Tyr Thr Val Val Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gly Ala Leu Arg Lys Leu 290 295 300 Ala Gly Arg Lys Ser Phe Phe Gln Arg Gln

305 310 <210> 3527 <211> 930 <212> DNA <213> Felis catus <400> 3527

gaaaaccaca cagcagtgac agagttcatt attctgggat taacagataa tcccacacta 60 tgtgccatct tctttgtgat ttttctggga gtttatgtag ttaccatagt gggaaatatc 120 agtataatca tcttaatccg aagcagccca cagctgcaca ccccaatgta cctttttctc 180 agccatttgg cctttgtgga cattgggtat tccacgtcag tcacgccaat catgctaatg 240 agttttttaa gagagaaaac aactatccct atcactggtt gtatagccca gcttggctct 300 gatgtcactt ttgggactac agaatgcttc ctgctggcta ccatggccta tgatcgctat 360 gtggccatct gctctccctt actctactcc acccagatgt cctcagtggt ctgcttcctc 420 ctactggggg cttcctacct gggtggatgc atgaacgctt catcatttac aggctgtctg 480 atgaatctat ctttctgtgg accaaataaa atcaaccatt ttttctgtga cctctttcca 540

Page 3947

069269_0225_SL.TXT

ctcttgaagc tttcttgtgg ccatgttttt attgctgaaa tatctcccgc catctcttct 600 gcatctgtcc tcataagcac actgtttacc ataattgtgt cctacagcta catcctccac 660 tcaattctga atatgcgctc tactgagggg aggaagaaag ccttctcaac ctgcacttcc 720 cacctcactg ccgtcacttt gttttatggg acagttttgt tcgtttatgt gatgcccaag 780 tccagttatt cagctgatca ggtcaaagtg gcctctgtca tctatacagt ggtggtcccc 840 atgttgaatc ccctcatcta cagtctgagg aacaaggagg tgaaaggggc catgagaaaa 900 ctaatggcca gaacacactg gttttcctga 930

<210> 3528 <211> 309 <212> PRT <213> Felis catus

<400> 3528 Val Thr Glu Phe Ile Ile Leu Gly Leu Thr Asp Glu 1 Asn His Thr Ala 5 10 15 Asn Pro Thr Leu Cys Ala Ile Phe Phe Val Ile Phe Leu Gly Val Tyr 20 25 30 Val Val Thr Ile Val Gly Asn Ile Ser Ile Ile Ile Leu Ile Arg Ser 35 40 45 Ser Pro Gln Leu His Thr Pro Met Tyr Leu Phe Leu Ser His Leu Ala 50 55 60 Phe Val Asp Ile Gly Tyr Ser Thr Ser Val Thr Pro Ile Met Leu Met 65 70 75 80 Ser Phe Leu Arg Glu Lys Thr Thr Ile Pro Ile Thr Gly Cys Ile Ala 85 90 95 Gln Leu Gly Ser Asp Val Thr Phe Gly Thr Thr Glu Cys Phe Leu Leu 100 105 110 Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser Pro Leu Leu 115 120 125

Page 3948

069269_0225_SL.TXT

Tyr Ser 130 Thr Gln Met Ser Ser Val Val Cys Phe Leu Leu Leu Gly Ala 135 140 Ser Tyr Leu Gly Gly Cys Met Asn Ala Ser Ser Phe Thr Gly Cys Leu 145 150 155 160 Met Asn Leu Ser Phe Cys Gly Pro Asn Lys Ile Asn His Phe Phe Cys 165 170 175 Asp Leu Phe Pro Leu Leu Lys Leu Ser Cys Gly His Val Phe Ile Ala 180 185 190 Glu Ile Ser Pro Ala Ile Ser Ser Ala Ser Val Leu Ile Ser Thr Leu 195 200 205 Phe Thr Ile Ile Val Ser Tyr Ser Tyr Ile Leu His Ser Ile Leu Asn 210 215 220 Met Arg Ser Thr Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys Thr Ser 225 230 235 240 His Leu Thr Ala Val Thr Leu Phe Tyr Gly Thr Val Leu Phe Val Tyr 245 250 255 Val Met Pro Lys Ser Ser Tyr Ser Ala Asp Gln Val Lys Val Ala Ser 260 265 270 Val Ile Tyr Thr Val Val Val Pro Met Leu Asn Pro Leu Ile Tyr Ser 275 280 285 Leu Arg Asn Lys Glu Val Lys Gly Ala Met Arg Lys Leu Met Ala Arg 290 295 300 Thr His Trp Phe Ser

<210> 3529 <211> 968 <212> DNA

305

Page 3949

069269_0225_SL.TXT <213> Felis catus <400> 3529

ttaatgtccg gtgttcttct actccccatc tgagggatga acctatttgt cttgcctaat 60 accttcctta gggctgtctg catgtctttg tttctgagac tgtaaacgat ggggttaagc 120 agaggtgtca gcactgtgta cgtgaccgcc atcagcatat cttcacggaa tgagtccctg 180 tccttgggcc tcaaatagac aaagccagca aatccatagt gtatgcacac cacagtgagg 240 tgggaggagc aagtggagaa ggccttatac ttccccttgg tagagggcat cttcacaact 300 ctggacacaa tgaagacata ggacatcata atgaaaacaa agctgcccac caacacgaag 360 gcagagagca caaaaatagc catttcgtga tgggaggtgt aatcacaggc aaggcagacc 420 acaggtgaga tgtcacagaa gtagtgctcg atgatgttgg agtcacagaa agacaagttg 480 aatacagtga tgacgatgca cagagaaacc aggaacccag ccatccaaga ggccatcatg 540 aactgaaagc agatcttatg ggtcatcaag accttatagt gcagtgggct gtgaatggca 600 gtgtaacggt cgtaagacat ggcagccatg atgaagcagt tattggctcc caagccaaag 660 aagaaaaaca tctgtgtggc acactcagga agagagatgg ccttgctatc tgacagcaag 720 tccactagca tgcgggggat gattgccata gtggtacaag tttctgaaaa ggacaggcca 780 cagaggaaaa aatacatggg ggtgtgaagg ttgtgactca gcttgatggc caccattatg 840 cacacatttg cagctaggat ggtcacatgg gagaagaaaa tcatcacaaa gaggagaccc 900 tgcaagtctg ggaaactgga aaacccccac agaaggaatg tgctcactgt ggtatgattg 960

tccatcat 968 <210> 3530 <211> 323 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (323)..(323) <223> Any amino acid <400> 3530

Met Met Asp Asn His Thr Thr Val Ser Thr Phe Leu Leu Trp Gly Phe 1 5 10 15

Page 3950

069269_0225_SL.TXT

Ser Ser Phe Pro 20 Asp Leu Gln Gly Leu Leu Phe Val Met Ile Phe Phe 25 30 Ser His Val Thr Ile Leu Ala Ala Asn Val Cys Ile Met Val Ala Ile 35 40 45 Lys Leu Ser His Asn Leu His Thr Pro Met Tyr Phe Phe Leu Cys Gly 50 55 60 Leu Ser Phe Ser Glu Thr Cys Thr Thr Met Ala Ile Ile Pro Arg Met 65 70 75 80 Leu Val Asp Leu Leu Ser Asp Ser Lys Ala Ile Ser Leu Pro Glu Cys 85 90 95 Ala Thr Gln Met Phe Phe Phe Phe Gly Leu Gly Ala Asn Asn Cys Phe 100 105 110 Ile Met Ala Ala Met Ser Tyr Asp Arg Tyr Thr Ala Ile His Ser Pro 115 120 125 Leu His Tyr Lys Val Leu Met Thr His Lys Ile Cys Phe Gln Phe Met 130 135 140 Met Ala Ser Trp Met Ala Gly Phe Leu Val Ser Leu Cys Ile Val Ile 145 150 155 160 Thr Val Phe Asn Leu Ser Phe Cys Asp Ser Asn Ile Ile Glu His Tyr 165 170 175 Phe Cys Asp Ile Ser Pro Val Val Cys Leu Ala Cys Asp Tyr Thr Ser 180 185 190 His His Glu Met Ala Ile Phe Val Leu Ser Ala Phe Val Leu Val Gly 195 200 205 Ser Phe Val Phe Ile Met Met Ser Tyr Val Phe Ile Val Ser Arg Val 210 215 220

Page 3951

069269_0225_SL.TXT

Val 225 Lys Met Pro Ser Thr Lys Gly Lys Tyr Lys Ala Phe Ser Thr Cys 230 235 240 Ser Ser His Leu Thr Val Val Cys Ile His Tyr Gly Phe Ala Gly Phe 245 250 255 Val Tyr Leu Arg Pro Lys Asp Arg Asp Ser Phe Arg Glu Asp Met Leu 260 265 270 Met Ala Val Thr Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Ile Val 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met Gln Thr Ala Leu Arg Lys Val Leu 290 295 300 Gly Lys Thr Asn Arg Phe Ile Pro Gln Met Gly Ser Arg Arg Thr Pro 305 310 315 320

Asp Ile Xaa <210> 3531 <211> 968 <212> DNA <213> Felis catus <400> 3531

atgatgggca atcataccac agcgagcaca ttccttctgt gggggttttc cagtttccca 60 gacttgcagg gtctcctctt tgtggtgatt ttcttctccc atgtgaccat cctagctgca 120 aatgtgtgca taatggtggc catcaagctg agtcacaacc ttcacacccc catgtatttt 180 ttcctctgtg gcctgtcctt ttcagaaact tgtaccacta tggcaatcat cccccgcatg 240 ctagtggact tgctgtcaga tagcaaggcc atctctcttc ctgagtgtgc cacacagatg 300 tttttcttct ttggcttggg agccaataac tgcttcatca tggctgccat gtcttacgac 360 cgttacactg ccattcacag cccactgcac tataaggtct tgatgaccca taagatctgc 420 tttcagttca tgatggcctc ttggatggct gggttcctgg tttctctgtg catcgtcatc 480

Page 3952

069269_0225_SL.TXT

actgtattca acttgtcttt ctgtgactcc aacatcatcg agcacttctt ctgtgacatc 540 tcacctgtgg tctgccttgc ctgtgattac acctcccatc acgaaatggc tatttttgtg 600 ctctctgcct tcgtgttggt gggcagcttt gttttcatta tgatgtccta tgtcttcatt 660 gtgtccagag ttgtgaagat gccctctgcc aaggggaagt ataaggcctt ctccacttgc 720 tcctcccacc tcactgtggt gtgcatacac tatggatttg ctggctttgt ctatttgagg 780 cccaaggaca gggactcatt ccgtgaagac atgctgatgg cggtcacata cacagtgctg 840 acacctctgc ttaaccccat cgtttacagt ctcagaaaca aagacatgca gacagcccta 900 aggaaggtat taggcaagac aaataggttc atccctcaga tggggagtag aagaacactg 960

gacattaa 968 <210> 3532 <211> 323 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (323)..(323) <223> Any amino acid

<400> 3532 His Thr 5 Thr Ala Ser Thr Phe Leu Leu Trp Gly Phe Met Met 1 Gly Asn 10 15 Ser Ser Phe Pro Asp Leu Gln Gly Leu Leu Phe Val Val Ile Phe Phe 20 25 30 Ser His Val Thr Ile Leu Ala Ala Asn Val Cys Ile Met Val Ala Ile 35 40 45 Lys Leu Ser His Asn Leu His Thr Pro Met Tyr Phe Phe Leu Cys Gly 50 55 60 Leu Ser Phe Ser Glu Thr Cys Thr Thr Met Ala Ile Ile Pro Arg Met 65 70 75 80 Leu Val Asp Leu Leu Ser Asp Ser Lys Ala Ile Ser Leu Pro Glu Cys Page 3953

069269_0225_SL.TXT

85 90 95

Ala Thr Gln Met Phe Phe Phe Phe Gly Leu Gly Ala Asn Asn Cys Phe 100 105 110 Ile Met Ala Ala Met Ser Tyr Asp Arg Tyr Thr Ala Ile His Ser Pro 115 120 125 Leu His Tyr Lys Val Leu Met Thr His Lys Ile Cys Phe Gln Phe Met 130 135 140 Met Ala Ser Trp Met Ala Gly Phe Leu Val Ser Leu Cys Ile Val Ile 145 150 155 160 Thr Val Phe Asn Leu Ser Phe Cys Asp Ser Asn Ile Ile Glu His Phe 165 170 175 Phe Cys Asp Ile Ser Pro Val Val Cys Leu Ala Cys Asp Tyr Thr Ser 180 185 190 His His Glu Met Ala Ile Phe Val Leu Ser Ala Phe Val Leu Val Gly 195 200 205 Ser Phe Val Phe Ile Met Met Ser Tyr Val Phe Ile Val Ser Arg Val 210 215 220 Val Lys Met Pro Ser Ala Lys Gly Lys Tyr Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Leu Thr Val Val Cys Ile His Tyr Gly Phe Ala Gly Phe 245 250 255 Val Tyr Leu Arg Pro Lys Asp Arg Asp Ser Phe Arg Glu Asp Met Leu 260 265 270 Met Ala Val Thr Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Ile Val 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met Gln Thr Ala Leu Arg Lys Val Leu

Page 3954

069269_0225_SL.TXT

290 295 300

Gly Lys Thr Asn Arg Phe Ile Pro Gln Met Gly Ser Arg Arg Thr Leu 305 310 315 320

Asp Ile Xaa <210> 3533 <211> 926 <212> DNA <213> Felis catus <400> 3533 tgccaagctc tctctcttca gagccacctt catctcactc ttcctgaggc tgtagatgag 60 ggggttcaat atggggatca ccaccatgta gaacacagac accaccttgt tctggtccgt 120 tgagtagccg gacttgggca tcacataaat gagcgtgttc gtcctatagc acagagtgac 180 cgctgtgagg tgggatgtac aagtggaaaa ggccttgtgg cgtcccttgg tggagcacat 240 cttcaggatg gtgatgagga tacggatgta ggaggcagct ctgacacacc gtgaccacaa 300 caatggagcc agccgtctac gaggggacac ttgcggaggt gctgatacca gagtgggaga 360 gtttaactaa aggagcaaaa tcacagagaa agtgatggac ttgatttgtt ccgcagaaga 420 gtaaaaaaag agaagcaaat agtagaagag aagcattgag aaaactacct acacaagcca 480 ccgtgagtca gcgaacacac acctgtgtgg acattttggt tgaataaagc agcgggtcac 540 agatggccat gaagcgatca gatgtcatgg cagccagaag gaggcactca cttgacccaa 600 agaaaacagc tgagctcacc tggacagcac gtccaagaca ggagattgta tgtctctcca 660 tcaggaagtt tacaagcata tgaggtgtga cagaagatga agagcctata tcagccaagg 720 gcaggcagct cagaaaaaac tacctaaggt ggtggggctg agaggcgagt ctgataagaa 780 tgattgtact gaggttgcca gatatggtcg ccaggtagat gcaaaggatg gttatgaaga 840 ggatggctca gaagacaggt tatcagttag gcccgatgaa atgaaccctg tcattgcagt 900 gtggttccca tcccccaggg aatcca 926 <210> 3534 <211> 80

Page 3955

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 3534 Lys Gly Arg 5 His Lys Ala Phe Ser Thr Cys Thr Ser Met Cys 1 Ser Thr 10 15 His Leu Thr Ala Val Thr Leu Cys Tyr Arg Thr Asn Thr Leu Ile Tyr 20 25 30 Val Met Pro Lys Ser Gly Tyr Ser Thr Asp Gln Asn Lys Val Val Ser 35 40 45 Val Phe Tyr Met Val Val Ile Pro Ile Leu Asn Pro Leu Ile Tyr Ser 50 55 60 Leu Arg Lys Ser Glu Met Lys Val Ala Leu Lys Arg Glu Ser Leu Ala 65 70 75 80

<210> 3535 <211> 946 <212> DNA <213> Felis catus <400> 3535

agagaagaaa atggcaagag gcaaccgtac cacagtgaca gaatttgtcc ttatgggatt 60 cacagagtgt cctgagctgc agcttcccct ttttgtggta ttcctggtaa tttatctcat 120 caccctggta ggaaaccttg gcatgatcct actcatcaag gtggatccaa ggctccacac 180 ccccatgtac tatttcctca gccacctggc tttcatcgat gtttgctact catcttccat 240 tgggcccaag atgctacaaa atttattggc aaagaaaaaa accatctcct tttcaggctg 300 ttttgcccag ctgtacttct ccagtgcttt tgccactact gaatgcttcc tcttggccac 360 aatggcctat gaccgctaca tggctatctg caaccccctg atttacccag ccgttatgac 420 tcagcgggtc tgcaaggagt tggtgatagg cgtctatacc tacggcttcc tgaactctgt 480 aatacaaaca gttctgactt ttcaattgtc tttctgcgac tccaatatca tccaccattt 540 ctactgcgct gaccctcctc tccttgccct ctcctgctct gacacccgca ccaaagagaa 600 gcagctcttg atcttctctg cagtgaatct cagtggatcc ttcctgactg tcctcatctc 660

Page 3956

069269_0225_SL.TXT ctacatctgc atcctccttt ccattataaa aattcagtct tctgaaggca agtgcaaagc cttttccacc tgtgcctccc acctcactgt ggtcatcgtc ttctatggaa cgctgttttt catgtacatg cagcaaccca aagcagggaa ttcatggaag tacaacaaag tggtctctgt gttttatagt cttgtcattc ccctgctcaa ccccctgatc tataccctga ggaacacaga agtaaaggac accctgaaaa agatgctaga aggcaaagag ccatag

720

780

840

900

946 <210> 3536 <211> 311 <212> PRT <213> Felis catus <400> 3536

Met Ala Arg Gly Asn Arg Thr Thr Val Thr Glu Phe Val Leu Met Gly 1 5 10 15

Phe Thr Glu Cys Pro Glu Leu Gln Leu Pro Leu Phe Val Val Phe Leu 20 25 30

Val Ile Tyr Leu Ile Thr Leu Val Gly Asn Leu Gly Met Ile Leu Leu 35 40 45

Ile Lys Val Asp Pro Arg Leu His Thr Pro Met Tyr Tyr Phe Leu Ser 50 55 60

His Leu Ala Phe Ile Asp Val Cys Tyr Ser Ser Ser Ile Gly Pro Lys 65 70 75 80

Met Leu Gln Asn Leu Leu Ala Lys Lys Lys Thr Ile Ser Phe Ser Gly 85 90 95

Cys Phe Ala Gln Leu Tyr Phe Ser Ser Ala Phe Ala Thr Thr Glu Cys 100 105 110

Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Asn 115 120 125

Pro Leu Ile Tyr Pro Ala Val Met Thr Gln Arg Val Cys Lys Glu Leu 130 135 140

Page 3957

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Val 145 Ile Gly Val Tyr Thr 150 Tyr Gly Phe Leu Asn Ser Val Ile Gln Thr 155 160 Val Leu Thr Phe Gln Leu Ser Phe Cys Asp Ser Asn Ile Ile His His 165 170 175 Phe Tyr Cys Ala Asp Pro Pro Leu Leu Ala Leu Ser Cys Ser Asp Thr 180 185 190 Arg Thr Lys Glu Lys Gln Leu Leu Ile Phe Ser Ala Val Asn Leu Ser 195 200 205 Gly Ser Phe Leu Thr Val Leu Ile Ser Tyr Ile Cys Ile Leu Leu Ser 210 215 220 Ile Ile Lys Ile Gln Ser Ser Glu Gly Lys Cys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ile Val Phe Tyr Gly Thr Leu Phe 245 250 255 Phe Met Tyr Met Gln Gln Pro Lys Ala Gly Asn Ser Trp Lys Tyr Asn 260 265 270 Lys Val Val Ser Val Phe Tyr Ser Leu Val Ile Pro Leu Leu Asn Pro 275 280 285 Leu Ile Tyr Thr Leu Arg Asn Thr Glu Val Lys Asp Thr Leu Lys Lys 290 295 300 Met Leu Glu Gly Lys Glu Pro

305 310 <210> 3537 <211> 946 <212> DNA <213> Felis catus <400> 3537 tcagaatatg tgtgaatcca cctttcttcg ccacaatttc atcaaagctc ttttcatctc

Page 3958

069269_0225_SL.TXT

actgtttctc aagctgtaga tcagtggatt caacagaggt gtaagaagtg agtaggacaa 120 tgacatcacc ttctttgttt ctggggagta gccagatttg ggttggatat aagtcatatt 180 ggctgtgcca tagaagaggg tcacagacgt gagatgggag gcacaggtgg aaaaggcctt 240 ttgcctcccg gtggccgatg gcatcttcag gatggcaaag agaatccgaa tataagacaa 300 gagaatcaac acaaagggga ccatgacaat caaaatggtg ccagtgaacg catagatttc 360 aaacagaaag gtgtctgcac atgcaagttc tagcactgct ggggtttcac aagagatgtg 420 attgatttca ttggggccac agaaaggaaa actaaaaacc catgtggtct gcacagtagc 480 caccatgatc cctgagaccc atgagaacat tactaatttc atgaaaaccc ttttgttcat 540 aatcattggg tagctcaggg gatggcagat tgcagcaaat cggtcataag ccatcacccc 600 caggagaaaa cattcagtcc caccaaaaaa aaagaataaa atacatctgt gcaaaacagc 660 tcacaaatga aattgacgtt ttctcagtgg agaggaccac cagcatttca ggcataatga 720 ctgcactgaa actcacatcc accacagaca ggttctgcag gaacaggtac atgggaacgt 780 ggaggctctg ttccagggag atgatgacta taatgatggc atttcccatc agagtcccaa 840 ggtaaacaac caagaaaacc ccaaagagct gctcttggag ttcaggaaag ttagaaaagc 900 ccaagaggat gaattcaacc acagagcttt gattttgcct tttcat 946

<210> 3538 <211> 197 <212> PRT <213> Felis catus

<400> 3538 Phe Ala Ala Ile Cys His Pro Leu Ser Tyr Pro Met 1 Ala Tyr Asp Arg 5 10 15 Met Ile Met Asn Lys Arg Val Phe Met Lys Leu Val Met Phe Ser Trp 20 25 30 Val Ser Gly Ile Met Val Ala Thr Val Gln Thr Thr Trp Val Phe Ser 35 40 45 Phe Pro Phe Cys Gly Pro Asn Glu Ile Asn His Ile Ser Cys Glu Thr 50 55 60

Page 3959

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Pro Ala Val Leu Glu Leu Ala Cys Ala Asp Thr Phe Leu Phe Glu Ile 65 70 75 80 Tyr Ala Phe Thr Gly Thr Ile Leu Ile Val Met Val Pro Phe Val Leu 85 90 95 Ile Leu Leu Ser Tyr Ile Arg Ile Leu Phe Ala Ile Leu Lys Met Pro 100 105 110 Ser Ala Thr Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala Ser His Leu 115 120 125 Thr Ser Val Thr Leu Phe Tyr Gly Thr Ala Asn Met Thr Tyr Ile Gln 130 135 140 Pro Lys Ser Gly Tyr Ser Pro Glu Thr Lys Lys Val Met Ser Leu Ser 145 150 155 160 Tyr Ser Leu Leu Thr Pro Leu Leu Asn Pro Leu Ile Tyr Ser Leu Arg 165 170 175 Asn Ser Glu Met Lys Arg Ala Leu Met Lys Leu Trp Arg Arg Lys Val 180 185 190 Asp Ser His Ile Phe

195 <210> 3539 <211> 963 <212> DNA <213> Felis catus <400> 3539 tcatcttgat attttcaatc tgcacattgt ctccttcaga gcctgctgta cctgcttatt gcgcagagtg tagatgacag ggttgagcag tggcgttacc accgtgttca caagggcagc ctccctgttg gagttcagcc tgttcctttg ctttggtttc acgtatataa agacacagct gccatacatc agagagagga caatgaggtg agacgagcag gtggagaaag ctttctgtcg

120

180

240

Page 3960

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ctccttggct gatgggagtc gcacaattgt gactactatg ttgctgtatg caatgatggt 300 tatgataagc gatgtcaaaa ggatcaacaa agcgatgaca aaggccaaca tttcaacaga 360 cctggtatta gaacaggaga gatgaatcaa aggatcaagg tcacagaaga agtggggaat 420 gacatggggg ccacagaacg ataactggga aaccattact agtggaccag tgatgagaat 480 gaaggccaaa acacagcagg cagtgaccaa gaggaagcaa gtcttgaggt tcatgatggt 540 tgggtaatgc aggggcttgc aaatggccat gtaccgatcc acagacatca ctgctatgag 600 gaggaaacct gctgctccca gatagacaaa cacaaaggct tgtatgaaac aggcaagaaa 660 ggaaatggtt tgccggccta aaagaaagat gaccagcaac ttaggaataa cagcacttat 720 gaaacaacac tcaaagaagg agaaagtgct gaggaaaaag tacataggtg tctggagccg 780 ggagtcagca caggtgatgg tgactatgac agcattgcct gtaatggatg ccaggtaggc 840 cagcaggtgc accaggaaga ggacctttcc caggtgttgg atggcaggaa acccctccaa 900 ggtgaattct tggacagtgg tcccgttccc tatttccatg ggcatctctt tccacagcat 960

cat 963 <210> 3540 <211> 320 <212> PRT <213> Felis catus <400> 3540

Met 1 Met Leu Trp Lys Glu Met Pro Met Glu Ile Gly Asn Gly Thr Thr 5 10 15 Val Gln Glu Phe Thr Leu Glu Gly Phe Pro Ala Ile Gln His Leu Gly 20 25 30 Lys Val Leu Phe Leu Val His Leu Leu Ala Tyr Leu Ala Ser Ile Thr 35 40 45 Gly Asn Ala Val Ile Val Thr Ile Thr Cys Ala Asp Ser Arg Leu Gln 50 55 60 Thr Pro Met Tyr Phe Phe Leu Ser Thr Phe Ser Phe Phe Glu Cys Cys 65 70 75 80

Page 3961

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Phe Ile Ser Ala Val Ile Pro Lys 85 Leu Leu Val Ile Phe Leu Leu Gly 90 95 Arg Gln Thr Ile Ser Phe Leu Ala Cys Phe Ile Gln Ala Phe Val Phe 100 105 110 Val Tyr Leu Gly Ala Ala Gly Phe Leu Leu Ile Ala Val Met Ser Val 115 120 125 Asp Arg Tyr Met Ala Ile Cys Lys Pro Leu His Tyr Pro Thr Ile Met 130 135 140 Asn Leu Lys Thr Cys Phe Leu Leu Val Thr Ala Cys Cys Val Leu Ala 145 150 155 160 Phe Ile Leu Ile Thr Gly Pro Leu Val Met Val Ser Gln Leu Ser Phe 165 170 175 Cys Gly Pro His Val Ile Pro His Phe Phe Cys Asp Leu Asp Pro Leu 180 185 190 Ile His Leu Ser Cys Ser Asn Thr Arg Ser Val Glu Met Leu Ala Phe 195 200 205 Val Ile Ala Leu Leu Ile Leu Leu Thr Ser Leu Ile Ile Thr Ile Ile 210 215 220 Ala Tyr Ser Asn Ile Val Val Thr Ile Val Arg Leu Pro Ser Ala Lys 225 230 235 240 Glu Arg Gln Lys Ala Phe Ser Thr Cys Ser Ser His Leu Ile Val Leu 245 250 255 Ser Leu Met Tyr Gly Ser Cys Val Phe Ile Tyr Val Lys Pro Lys Gln 260 265 270 Arg Asn Arg Leu Asn Ser Asn Arg Glu Ala Ala Leu Val Asn Thr Val 275 280 285

Page 3962

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Val Thr Pro Leu Leu Asn Pro Val Ile Tyr Thr Leu Arg Asn Lys Gln 290 295 300

Val Gln Gln Ala Leu Lys Glu Thr Met Cys Arg Leu Lys Ile Ser Arg 305 310 315 320

<210> 3541 <211> 960 <212> DNA <213> Felis catus <400> 3541

tcttgatatt ttcattctgc acattgtctc tctcagaacc tggtggacct gcttattccg 60 cagagtgtag atgacagggt tcaacagcgg ggtcaccacc gtatgcacaa gggcagcctc 120 cctgttggag ttcagcctgt tggtttgctt tggtttcacg tatataaaga cacagctgct 180 gtatatcagg gagaggacta tgaagtgaga ggagcaggtg gagaaagctt tctgtcgctc 240 cttggctgat gggagtcgca caattgtgac tactatgttg ctgtatgcaa tgatggttat 300 gataagcgat gtcaaaatga taaacaaagc aatgacaaag gccaacattt caacaaacct 360 ggtattagaa caggagagat gaatcaggga accaagatca cagaagaagt gggggatgac 420 attggggcca cagaacgata actgggaaac ctttactatc agaccagtga tgagaaggaa 480 ggccaaaaca cagcaggcag tgaccaagag gaagcaagtc ttgaggttca tgatggttgg 540 gtaatgcaga ggcttgcaaa tggccatgta ccgatccaca gacatcactg ttatgaggaa 600 gaaacctgtg gctccgaggt atacatacac aaaggcttgt atgaaacagg caagaaagga 660 aatggtttgc cggcctaaaa gaaagatgac cagcaactta ggaataacag cacttatgaa 720 acaacactca aagaaggaga aagtgctgag gaaaaagtac ataggtgtct ggagccggga 780 gtcagcacag gtgatggtga ctatgacagc attgcctgta atggatgcca ggtaggccag 840 caggtgcacc aggaagagga cctttcccag gtgttggatg gcaggaaacc cctccaaggt 900 gaattcttgg acagtggtcc cgttccctat ttccatgggc atctctttcc acagcatcat 960

<210> 3542 <211> 320 <212> PRT <213> Felis catus

Page 3963

069269_0225_SL.TXT <400> 3542

Met 1 Met Leu Trp Lys 5 Glu Met Pro Met Glu Ile Gly Asn Gly Thr Thr 10 15 Val Gln Glu Phe Thr Leu Glu Gly Phe Pro Ala Ile Gln His Leu Gly 20 25 30 Lys Val Leu Phe Leu Val His Leu Leu Ala Tyr Leu Ala Ser Ile Thr 35 40 45 Gly Asn Ala Val Ile Val Thr Ile Thr Cys Ala Asp Ser Arg Leu Gln 50 55 60 Thr Pro Met Tyr Phe Phe Leu Ser Thr Phe Ser Phe Phe Glu Cys Cys 65 70 75 80 Phe Ile Ser Ala Val Ile Pro Lys Leu Leu Val Ile Phe Leu Leu Gly 85 90 95 Arg Gln Thr Ile Ser Phe Leu Ala Cys Phe Ile Gln Ala Phe Val Tyr 100 105 110 Val Tyr Leu Gly Ala Thr Gly Phe Phe Leu Ile Thr Val Met Ser Val 115 120 125 Asp Arg Tyr Met Ala Ile Cys Lys Pro Leu His Tyr Pro Thr Ile Met 130 135 140 Asn Leu Lys Thr Cys Phe Leu Leu Val Thr Ala Cys Cys Val Leu Ala 145 150 155 160 Phe Leu Leu Ile Thr Gly Leu Ile Val Lys Val Ser Gln Leu Ser Phe 165 170 175 Cys Gly Pro Asn Val Ile Pro His Phe Phe Cys Asp Leu Gly Ser Leu 180 185 190 Ile His Leu Ser Cys Ser Asn Thr Arg Phe Val Glu Met Leu Ala Phe 195 200 205

Page 3964

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Val Ile Ala Leu Phe Ile Ile Leu Thr Ser Leu Ile Ile Thr Ile Ile 210 215 220 Ala Tyr Ser Asn Ile Val Val Thr Ile Val Arg Leu Pro Ser Ala Lys 225 230 235 240 Glu Arg Gln Lys Ala Phe Ser Thr Cys Ser Ser His Phe Ile Val Leu 245 250 255 Ser Leu Ile Tyr Ser Ser Cys Val Phe Ile Tyr Val Lys Pro Lys Gln 260 265 270 Thr Asn Arg Leu Asn Ser Asn Arg Glu Ala Ala Leu Val His Thr Val 275 280 285 Val Thr Pro Leu Leu Asn Pro Val Ile Tyr Thr Leu Arg Asn Lys Gln 290 295 300 Val His Gln Val Leu Arg Glu Thr Met Cys Arg Met Lys Ile Ser Arg 305 310 315 320

<210> 3543 <211> 927 <212> DNA <213> Felis catus <400> 3543

atggcctggg gccgcagcca gaacctctcc acattcatcc tactgggctt cccggggcca 60 cggggcctgc agacctggct cttcctcctc ttcctggtcg cgtacgtgct cacggtggcc 120 gggaacctgg ccatcatctc cctggtcggg gcgcaccggc gcctgcagac gcccatgtac 180 ttcttcctct gcaacctctc cttcctggag atctggttca ccacggcctg tgtgcccaag 240 gccctggcca cgttcgcctc gcacagtgga gccatctcct tggccggctg cgcggcgcag 300 atgtacttcg tcttctcgct gggctgcacc gagtacttcc tgctggccgc gatggcttac 360 gaccgctacc tggccatctg cctgccgctg cgctacggca gcaccatgac gcctgggctc 420 tccgcccgcc tcgctctggg ctcctggctg tgcggcttct ccgccatcac cgtgcccgct 480

Page 3965

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gccctcattg ctcgcctctc cttctgccgc tcccacgtca tcaaccactt cttctgtgac 540 atcgcgccct ggatcgtgct gtcctgcagc gacacgcggg gtgtggagct ggcggccttc 600 ggcattgcct tctgtgtcat cctgggctcc tgctttgtca cgctgctctc ctacgcctac 660 atcgctgcca ccatcatcag gatcccctcg gcccggggcc ggcacagagc cttctccacc 720 tgctcctccc atctcaccgt ggtcctcatc tggtacggct ccaccatctt cctgcatgtg 780 aggacctcgg tggagagctc gctggacctg accaaggccg tcacggtgct gaacaccgtt 840 gtcactcccg tgctgaaccc cttcatatac accctgagga acaaggacgt cagggaggct 900 ctgcggaggt cggtgcagcg gaagtga 927

<210> 3544 <211> 308 <212> PRT <213> Felis catus

<400> 3544 Ser Gln Asn Leu Ser Thr Phe Ile Leu Leu Gly Met Ala 1 Trp Gly Arg 5 10 15 Phe Pro Gly Pro Arg Gly Leu Gln Thr Trp Leu Phe Leu Leu Phe Leu 20 25 30 Val Ala Tyr Val Leu Thr Val Ala Gly Asn Leu Ala Ile Ile Ser Leu 35 40 45 Val Gly Ala His Arg Arg Leu Gln Thr Pro Met Tyr Phe Phe Leu Cys 50 55 60 Asn Leu Ser Phe Leu Glu Ile Trp Phe Thr Thr Ala Cys Val Pro Lys 65 70 75 80 Ala Leu Ala Thr Phe Ala Ser His Ser Gly Ala Ile Ser Leu Ala Gly 85 90 95 Cys Ala Ala Gln Met Tyr Phe Val Phe Ser Leu Gly Cys Thr Glu Tyr 100 105 110

Phe Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Leu Page 3966

115 069269_0225_SL.TXT 120 125 Pro Leu Arg Tyr Gly Ser Thr Met Thr Pro Gly Leu Ser Ala Arg Leu 130 135 140 Ala Leu Gly Ser Trp Leu Cys Gly Phe Ser Ala Ile Thr Val Pro Ala 145 150 155 160 Ala Leu Ile Ala Arg Leu Ser Phe Cys Arg Ser His Val Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Ala Pro Trp Ile Val Leu Ser Cys Ser Asp Thr 180 185 190 Arg Gly Val Glu Leu Ala Ala Phe Gly Ile Ala Phe Cys Val Ile Leu 195 200 205 Gly Ser Cys Phe Val Thr Leu Leu Ser Tyr Ala Tyr Ile Ala Ala Thr 210 215 220 Ile Ile Arg Ile Pro Ser Ala Arg Gly Arg His Arg Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Leu Ile Trp Tyr Gly Ser Thr Ile 245 250 255 Phe Leu His Val Arg Thr Ser Val Glu Ser Ser Leu Asp Leu Thr Lys 260 265 270 Ala Val Thr Val Leu Asn Thr Val Val Thr Pro Val Leu Asn Pro Phe 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Arg Glu Ala Leu Arg Arg Ser 290 295 300

Val Gln Arg Lys 305 <210> 3545

Page 3967

069269_0225_SL.TXT <211> 938 <212> DNA <213> Felis catus <400> 3545

gggcacccag ggcctgggcc accctctgca ctgccttgcg tagggcctcc ttgacctcct 60 ggttccgcag gcagtagatg atggggttga gcaggggcgt gagcaccgtg tagaccacgg 120 acaccacctt gttgaagtca aaggagtaga tggcgcgtgg ccgggcgtag atgaagaggg 180 aggcggagta gaagatgacc accacggcca ggtgcgaggc acaggtggag aaggccttgc 240 gccggccggc ggcggacggg atgcgcagca cggtgccgag gatggcggcg tacgagaaga 300 tggtgagctg cagcggcccc agcaggatga gcagagccag gaggaagtcg accagctccg 360 ccacggacac gtcggagcac gcgaggctca gcagggggga cacgtcgcag aagaagtggt 420 tcatgacgtt ggggccacag tagcccaggc gtgagatgaa gaagaccttt cccaaggaga 480 cggtgaagcc cgagagccag gagctggcgg ccaggaagct gcagaggctg gggctcatga 540 tggccgggta gcgcaggggg ctgcagatgg ccacgtagcg gtcgtaggcc atgacgccca 600 ggagcgtgca ctcggtgcag gccagcgcca ggaagaaata cagctgcgtc atgcagcccg 660 tgaaggagat gtgtcggaac tggggctccg ccaggctgag cagcatcttg ggcacggtga 720 cggagacgta ccacacctcc aggaaggaca ggttgctgag gaagacatac atgggcttgt 780 gcagctgggg gctgacccgg atcacggcga cgacgaccac gttctctgtg acggtcagca 840 tgtaggccag cgtgaacagc accaccaggc acacttggag gcccagcgag cccgagaagc 900 ccaccaggat gaactctgtc acctccgagc gattgtcc 938

<210> 3546 <211> 313 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (313)..(313) <223> Any amino acid <400> 3546

Asp Asn Arg Ser Glu Val Thr Glu Phe Ile Leu Val Gly Phe Ser Gly 1 5 10 15

Page 3968

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Ser Leu Gly Leu 20 Gln Val Cys Leu Val Val Leu Phe Thr Leu Ala Tyr 25 30 Met Leu Thr Val Thr Glu Asn Val Val Val Val Ala Val Ile Arg Val 35 40 45 Ser Pro Gln Leu His Lys Pro Met Tyr Val Phe Leu Ser Asn Leu Ser 50 55 60 Phe Leu Glu Val Trp Tyr Val Ser Val Thr Val Pro Lys Met Leu Leu 65 70 75 80 Ser Leu Ala Glu Pro Gln Phe Arg His Ile Ser Phe Thr Gly Cys Met 85 90 95 Thr Gln Leu Tyr Phe Phe Leu Ala Leu Ala Cys Thr Glu Cys Thr Leu 100 105 110 Leu Gly Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Ser Pro Leu 115 120 125 Arg Tyr Pro Ala Ile Met Ser Pro Ser Leu Cys Ser Phe Leu Ala Ala 130 135 140 Ser Ser Trp Leu Ser Gly Phe Thr Val Ser Leu Gly Lys Val Phe Phe 145 150 155 160 Ile Ser Arg Leu Gly Tyr Cys Gly Pro Asn Val Met Asn His Phe Phe 165 170 175 Cys Asp Val Ser Pro Leu Leu Ser Leu Ala Cys Ser Asp Val Ser Val 180 185 190 Ala Glu Leu Val Asp Phe Leu Leu Ala Leu Leu Ile Leu Leu Gly Pro 195 200 205 Leu Gln Leu Thr Ile Phe Ser Tyr Ala Ala Ile Leu Gly Thr Val Leu 210 215 220

Page 3969

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Arg 225 Ile Pro Ser Ala Ala Gly Arg Arg Lys Ala Phe Ser Thr Cys Ala 230 235 240 Ser His Leu Ala Val Val Val Ile Phe Tyr Ser Ala Ser Leu Phe Ile 245 250 255 Tyr Ala Arg Pro Arg Ala Ile Tyr Ser Phe Asp Phe Asn Lys Val Val 260 265 270 Ser Val Val Tyr Thr Val Leu Thr Pro Leu Leu Asn Pro Ile Ile Tyr 275 280 285 Cys Leu Arg Asn Gln Glu Val Lys Glu Ala Leu Arg Lys Ala Val Gln 290 295 300 Arg Val Ala Gln Ala Leu Gly Ala Xaa 305 310

<210> 3547 <211> 903 <212> DNA <213> Felis catus <400> 3547

gaacagcctc cggagggcag ctttgacctc cgtgttcctc agggagtaga taagggggtt 60 cagggagggc gccaccgaag tgtagatcac agacaccacc ttgtccttgt gcaatgagta 120 tctggatgct gggcggatgt aggtgtagat gacagtgcag tagtacaggg agaccaccag 180 gaggtgggag gagcaggtgg agaaggcccg tcgcttgcct gaggccgagc ggatgcgcag 240 gatgctggcg atgatgcagc cgtaggagag catgatcaca gagaagttcc ccaaggccag 300 gatcacgtct gcagtgaagg ccatggcctc gttcaggcgt gtcggggcac aggagagctt 360 cagcagaggg gggatctcac agaagaagtg ctcgaccacg ttggaatggc agaagggcag 420 gtgcagcagg aggccggtgt tcacactagt gttggccagg ctgatggtcc acacggccac 480 ggccaagagc ctgcaaaccc gggagtccat gagggtgctg tagcgcaggg gccagcagat 540 ggccacgtag cggtcatagg ccatggcgga aaacagcagc agctcagctc ccagagacca 600

Page 3970

069269_0225_SL.TXT cgtgaaggag aaaagctgca ctatgcaacc cccgtaggag atggtcctgt cagccaccat gctgcccagg agcttgggca ggatcgtgga ggtgcagagg atgtccacca cggccaggtt taccaggaag aagtacatgg gggtgtgcaa ggcagggcag gagccaatgg ccaccatgat gagcaggttt ccagagaggg ccaccatgta gaggaggagg aagacaggaa agaggagcat ttgcagctga ggtgtttctg agaatcccag aatgaggaac tcggtgacca gtgtctggtt cat

660

720

780

840

900

903 <210> 3548 <211> 301 <212> PRT <213> Felis catus

<400> 3548 Val Thr Glu Phe Leu Ile Leu Gly Phe Ser Glu Met 1 Asn Gln Thr Leu 5 10 15 Thr Pro Gln Leu Gln Met Leu Leu Phe Pro Val Phe Leu Leu Leu Tyr 20 25 30 Met Val Ala Leu Ser Gly Asn Leu Leu Ile Met Val Ala Ile Gly Ser 35 40 45 Cys Pro Ala Leu His Thr Pro Met Tyr Phe Phe Leu Val Asn Leu Ala 50 55 60 Val Val Asp Ile Leu Cys Thr Ser Thr Ile Leu Pro Lys Leu Leu Gly 65 70 75 80 Ser Met Val Ala Asp Arg Thr Ile Ser Tyr Gly Gly Cys Ile Val Gln 85 90 95 Leu Phe Ser Phe Thr Trp Ser Leu Gly Ala Glu Leu Leu Leu Phe Ser 100 105 110 Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Trp Pro Leu Arg Tyr 115 120 125

Ser Thr Leu Met Asp

Ser Arg Val

Cys Arg

Leu Leu

Ala Val Ala Val

Page 3971

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130 135 140 Trp Thr Ile Ser Leu Ala Asn Thr Ser Val Asn Thr Gly Leu Leu Leu 145 150 155 160 His Leu Pro Phe Cys His Ser Asn Val Val Glu His Phe Phe Cys Glu 165 170 175 Ile Pro Pro Leu Leu Lys Leu Ser Cys Ala Pro Thr Arg Leu Asn Glu 180 185 190 Ala Met Ala Phe Thr Ala Asp Val Ile Leu Ala Leu Gly Asn Phe Ser 195 200 205 Val Ile Met Leu Ser Tyr Gly Cys Ile Ile Ala Ser Ile Leu Arg Ile 210 215 220 Arg Ser Ala Ser Gly Lys Arg Arg Ala Phe Ser Thr Cys Ser Ser His 225 230 235 240 Leu Leu Val Val Ser Leu Tyr Tyr Cys Thr Val Ile Tyr Thr Tyr Ile 245 250 255 Arg Pro Ala Ser Arg Tyr Ser Leu His Lys Asp Lys Val Val Ser Val 260 265 270 Ile Tyr Thr Ser Val Ala Pro Ser Leu Asn Pro Leu Ile Tyr Ser Leu 275 280 285 Arg Asn Thr Glu Val Lys Ala Ala Leu Arg Arg Leu Phe 290 295 300

<210> 3549 <211> 980 <212> DNA <213> Felis catus <400> 3549 ctagctgtct tgcgtgacac agttgaagag caacagggaa ggtgggacaa tttcctggag agcaggtctc cccagagcag ggctaggaca gcagatttca cctctgcatt cctcaggctg Page 3972

120

069269_0225_SL.TXT

tagatgatgg ggtttagtga gggcgtcacg accccataga acaatgcaat aatcttatcc 180 aggttggggt cctcggcctt ggacttgaag tacatgaagg agatggtccc gtagaaaacc 240 accacaactg tgaggtgggc agagcaggtg gagaaggctt tgcaccggcc tgcggcagag 300 ggcaccctaa ggatggcagc aaggatgaga atgtaggaca ggcagatgag gaggagtggg 360 gccagcgtca ggacagccgt ggccatgatt aatagcagtg cattgagaga gatgtcccca 420 caggacagtt tcagcactgc caagatctca cagaagaagt gattgatgat attgtggcca 480 cagaagggga ggctccaggt gagaagggac tgcagcagtg aattggcaaa acctgtcccc 540 cagctcagca ctgccatcca caggcacgtc cacctactca tgatctctgt gtacctaagc 600 ggctggcaga tagccacata acggtcatat gccatcacag ccaggagcag gcactccgtg 660 gagcccagcg ccagggtcag gtacatctgc agggcacaac caaggaagga gatggtcctt 720 tgggcttcca ggaagttggt cagcatgaga ggcacaaagg aggatgtgcc acagatgtcc 780 atgagggaga ggttgctgag aaagaagtac atggggctgt gcaggcgggg gtccagcatg 840 tttaggccga tgaggaggga gttccccagc acattcatgg agtagatgcc caggcagagc 900 acaaacagga ccatctctag gttagggtgc tcgtgtagcc ccagcaagat gtattctgtc 960 acagccgtct ggtttgccat 980

<210> 3550 <211> 327 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (327)..(327) <223> Any amino acid <400> 3550

Met Ala Asn Gln Thr Ala Val Thr Glu Tyr Ile Leu Leu Gly Leu His 1 5 10 15

Glu His Pro Asn Leu Glu Met Val Leu Phe Val Leu Cys Leu Gly Ile 20 25 30

Page 3973

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Tyr Ser Met 35 Asn Val Leu Gly Asn Ser Leu Leu Ile Gly Leu Asn Met 40 45 Leu Asp Pro Arg Leu His Ser Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Met Asp Ile Cys Gly Thr Ser Ser Phe Val Pro Leu Met Leu 65 70 75 80 Thr Asn Phe Leu Glu Ala Gln Arg Thr Ile Ser Phe Leu Gly Cys Ala 85 90 95 Leu Gln Met Tyr Leu Thr Leu Ala Leu Gly Ser Thr Glu Cys Leu Leu 100 105 110 Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln Pro Leu 115 120 125 Arg Tyr Thr Glu Ile Met Ser Arg Trp Thr Cys Leu Trp Met Ala Val 130 135 140 Leu Ser Trp Gly Thr Gly Phe Ala Asn Ser Leu Leu Gln Ser Leu Leu 145 150 155 160 Thr Trp Ser Leu Pro Phe Cys Gly His Asn Ile Ile Asn His Phe Phe 165 170 175 Cys Glu Ile Leu Ala Val Leu Lys Leu Ser Cys Gly Asp Ile Ser Leu 180 185 190 Asn Ala Leu Leu Leu Ile Met Ala Thr Ala Val Leu Thr Leu Ala Pro 195 200 205 Leu Leu Leu Ile Cys Leu Ser Tyr Ile Leu Ile Leu Ala Ala Ile Leu 210 215 220 Arg Val Pro Ser Ala Ala Gly Arg Cys Lys Ala Phe Ser Thr Cys Ser 225 230 235 240

Page 3974

Ala His Leu Thr Val 245 Val Val 069269_0225_SL.TXT Val Phe Tyr Gly Thr Ile 250 Ser Phe 255 Met Tyr Phe Lys Ser 260 Lys Ala Glu Asp Pro 265 Asn Leu Asp Lys Ile 270 Ile Ala Leu Phe Tyr 275 Gly Val Val Thr Pro 280 Ser Leu Asn Pro Ile 285 Ile Tyr Ser Leu Arg 290 Asn Ala Glu Val Lys 295 Ser Ala Val Leu Ala 300 Leu Leu Trp Gly Asp 305 Leu Leu Ser Arg Lys 310 Leu Ser His Leu Pro 315 Cys Cys Ser Ser Thr 320 Val Ser Arg Lys Thr 325 Ala Xaa

<210> 3551 <211> 954 <212> DNA <213> Felis catus <400> 3551

tcacttggag gtccaacttc taccccacac tttcctggca gcctccttca cttccgtgtt 60 cctcaagctg tagatgacag ggttcagcat gggtgtgacc acggcataga ggaccgtgaa 120 gacctcgtca gagatgcgtg ccttcttgct cttgggtttc atgtacgtga atattacggt 180 gccatagaaa agcatcacca cagccaggtg tgccgagcag gtggagaagg ctttgcggcg 240 cccagcggct gaaggcaccc tcaggatggt ggccagaata agtatgtagg acaggcagat 300 gaatgccagg ggtacaggca gcagcagaat ggcgcccacc agcaggaaga cttcactgac 360 tgacgtgtcg ccgcatgcca gcttcagcac tgccaggatc tcacaggtga agtgactaac 420 cacttggcgg ccacagaagg gcaacctcat ggcaatgacc gtctcagtca ccgacttgaa 480 gaggcagagg ccccaggcgg ttcccgccag gaagaagcag agccggtggc tcatgagcac 540 ggggtacctg agtggccggc aaatggccag gtagcgatcg taggccatga tagcgagcag 600 tagacactct gtggagcctg cggacaggct cagacacatc tggactgcac agccaataaa 660

Page 3975

069269_0225_SL.TXT ggagatggtc ttctgagctg acaggaggtg gaccagcatc agaggcacaa aggtggacgt gtagcagatg tccaggatgg agaggttgcc caggaagaag tacatgggtg tgtgcaggcg gacatctaag acactcactg ccacgatggc agtgtttccc agcagggtca ccaggtacat ggctgagcac agagggaaga gcaggtgctc cagggccggg tagccagaaa atcctttcag aaagaactca gagatctctg tcctattgac cagctccata ctgcagcgct cagg

720

780

840

900

954 <210> 3552 <211> 312 <212> PRT <213> Felis catus <400> 3552

Met Glu Leu Val 1 Asn 5 Arg Thr Glu Ile Ser Glu Phe Phe Leu Lys Gly 10 15 Phe Ser Gly Tyr Pro Ala Leu Glu His Leu Leu Phe Pro Leu Cys Ser 20 25 30 Ala Met Tyr Leu Val Thr Leu Leu Gly Asn Thr Ala Ile Val Ala Val 35 40 45 Ser Val Leu Asp Val Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Ile Leu Asp Ile Cys Tyr Thr Ser Thr Phe Val Pro Leu 65 70 75 80 Met Leu Val His Leu Leu Ser Ala Gln Lys Thr Ile Ser Phe Ile Gly 85 90 95 Cys Ala Val Gln Met Cys Leu Ser Leu Ser Ala Gly Ser Thr Glu Cys 100 105 110 Leu Leu Leu Ala Ile Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 Pro Leu Arg Tyr Pro Val Leu Met Ser His Arg Leu Cys Phe Phe Leu 130 135 140

Page 3976

069269_0225_SL.TXT

Ala Gly Thr Ala Trp Gly Leu Cys Leu Phe Lys Ser Val Thr Glu Thr 145 150 155 160 Val Ile Ala Met Arg Leu Pro Phe Cys Gly Arg Gln Val Val Ser His 165 170 175 Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Gly Asp Thr 180 185 190 Ser Val Ser Glu Val Phe Leu Leu Val Gly Ala Ile Leu Leu Leu Pro 195 200 205 Val Pro Leu Ala Phe Ile Cys Leu Ser Tyr Ile Leu Ile Leu Ala Thr 210 215 220 Ile Leu Arg Val Pro Ser Ala Ala Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Ala Val Val Met Leu Phe Tyr Gly Thr Val Ile 245 250 255 Phe Thr Tyr Met Lys Pro Lys Ser Lys Lys Ala Arg Ile Ser Asp Glu 260 265 270 Val Phe Thr Val Leu Tyr Ala Val Val Thr Pro Met Leu Asn Pro Val 275 280 285 Ile Tyr Ser Leu Arg Asn Thr Glu Val Lys Glu Ala Ala Arg Lys Val 290 295 300 Trp Gly Arg Ser Trp Thr Ser Lys 305 310 <210> 3553 <211> 955 <212> DNA <213> Felis catus <400> 3553 ggtgaagtat ttccgagcca ccaggttcct cacagcagcc ttcacgtcct tgttcctgag 60

Page 3977

069269_0225_SL.TXT

gctgtagatg acggggttga gcatgggggt caccacccca tagaagagag ggatgagctt 120 atctgaaagg tcctctttgt ctgcccccag gggatcctta gacttgggct tcctgtacat 180 gaaaaataag gtcccataga agatgaccac cacagtgagg tgggcagagc aggtagaaaa 240 ggcctttttc ctcccctcag ctgaagggat cctcaggatg gtagcaatga tgaagacata 300 agagacagag atgaacagaa ctgggacccc caggaagatc acatttgtca ctcccatgct 360 gatcacattg atggagatgt caacacaggc caacttgagg actgccagga tctcacaggc 420 aaggtggttg atgacgttgt tcccgcagaa aggcagctga atcgtcaggg gatgtgtgta 480 ccacagaagc agccccacca attgtccagg agctgacagc catggataca tacacagacc 540 tgctcatgac cacagggtac ctcagggggt tacagatggc cacatagcga tcaaatgcca 600 tcacgctcag gcgcacacac tctgtccctg ccatggcaaa ggagaggaac atctgcatgg 660 cacaacctga gaaggagata gttttcctgg gagtgaggaa gccatccagg actagaggga 720 tggaagaggt tgtgtagcag atgtccagga aggagaggtt ccccaggaag aagtacatgg 780 gcgtgtgcag gcgggagtca aggatggtca ccaggatgag gaccccattg cccagcagga 840 tcaccagata catagacagg atgagcacaa agaacgtttt ctccagcctt gggtgggctg 900 agagtcccag gagaatgaac cccaccacgg gggaggacca gttggctttt tccat 955

<210> 3554 <211> 180 <212> PRT <213> Felis catus

<400> 3554 Trp Ser Ser Pro Val Val Gly Phe Ile Leu Leu Met 1 Glu Lys Ala Asn 5 10 15 Gly Leu Ser Ala His Pro Arg Leu Glu Lys Thr Phe Phe Val Leu Ile 20 25 30 Leu Ser Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu 35 40 45 Val Thr Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60

Page 3978

069269_0225_SL.TXT

Gly 65 Asn Leu Ser Phe Leu Asp 70 Ile Cys Tyr Thr Thr Ser Ser Ile Pro 75 80 Leu Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser 85 90 95 Gly Cys Ala Met Gln Met Phe Leu Ser Phe Ala Met Ala Gly Thr Glu 100 105 110 Cys Val Arg Leu Ser Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Pro Val Val Met Ser Arg Ser Val Tyr Val Ser 130 135 140 Met Ala Val Ser Ser Trp Thr Ile Gly Gly Ala Ala Ser Val Val His 145 150 155 160 Thr Ser Pro Asp Asp Ser Ala Ala Phe Leu Arg Glu Gln Arg His Gln 165 170 175

Pro Pro Cys Leu 180 <210> 3555 <211> 979 <212> DNA <213> Felis catus <220>

<221> modified_base <222> (135)..(154) <223> a, c, t, g, unknown or other <400> 3555 tcactggatg aagtgtttct gaaataccag gttcctcaca gcggccttca cgtccttgtt cctcaggcta tagatgatgg ggttggagca tgggggtcga ccaccccata gaagagggag atgagcttat ctgannnnnn nnnnnnnnnn nnnnctgctt gtctgccccc agggggtccg

120

180

Page 3979

069269_0225_SL.TXT

ttggatttgg ggtcttccca tacatgaaaa ggatagtccc atagaagacg accacgactg 240 tgaggtgggc agagcaggtg gagaaggcct ttttcctccc ctcagctgag gggatcctca 300 ggatagtggt gaggatgaag atgtaggaga taaagatgaa cagaactggg acccccagga 360 agatcacatt ggctactgcc atactgatca cattgatgga gatatcagca caggccaact 420 tcaggacagc caagatctca caggtgaagt ggttaatgac gttgtcacca cagaagggca 480 accgcattgc taaggatgtt tgcaccatgg cagtcgtgct tccagctgcc caggagctgg 540 cagccatggg cacgtagaca gccttgctca tgaccacagg gtacctaaga gggttacaaa 600 tggccacata gcgatcaaat gccatcatgc ccagaagcac acactctgtg gctcccatgg 660 cgaaggaaag aaacatttgc acagcacagg ctgagaaggg tacagttttc ctgggggtca 720 ggaagctgtc gagaatgagg gggactgagg aggttgtgta gcagatgtcc aggaaggaga 780 ggttccccag gaagaagtac atgggcgtgt gcaggcggga gacagacaca gtgaccagga 840 tgaggacccc attgcccagc aggatcacca agtacatcag gaggatgagc acaaagaacg 900 ttttctctag ctttgggtgg gctgagagtc ccaggagaat aaaccccatc acaggagaag 960 tccaattgga tctctccat 979

<210> 3556 <211> 303 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (276)..(282) <223> Any amino acid

<400> 3556 Trp Thr Ser Pro Val Met Gly Phe Ile Leu Leu Met 1 Glu Arg Ser Asn 5 10 15 Gly Leu Ser Ala His Pro Lys Leu Glu Lys Thr Phe Phe Val Leu Ile 20 25 30 Leu Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu 35 40 45

Page 3980

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Val Thr 50 Val Ser Val Ser Arg Leu 55 His Thr Pro Met Tyr Phe Phe 60 Leu Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro 65 70 75 80 Leu Ile Leu Asp Ser Phe Leu Thr Pro Arg Lys Thr Val Pro Phe Ser 85 90 95 Ala Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu 100 105 110 Cys Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Val Tyr Val Pro 130 135 140 Met Ala Ala Ser Ser Trp Ala Ala Gly Ser Thr Thr Ala Met Val Gln 145 150 155 160 Thr Ser Leu Ala Met Arg Leu Pro Phe Cys Gly Asp Asn Val Ile Asn 165 170 175 His Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp 180 185 190 Ile Ser Ile Asn Val Ile Ser Met Ala Val Ala Asn Val Ile Phe Leu 195 200 205 Gly Val Pro Val Leu Phe Ile Phe Ile Ser Tyr Ile Phe Ile Leu Thr 210 215 220 Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ala His Leu Thr Val Val Val Val Phe Tyr Gly Thr Ile 245 250 255

Page 3981

069269_0225_SL.TXT

Leu Phe Met Tyr Gly Lys Thr Pro Asn Pro Thr Asp Pro Leu Gly Ala 260 265 270 Asp Lys Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ile Ser Ser Ser Pro 275 280 285 Ser Ser Met Gly Trp Ser Thr Pro Met Leu Gln Pro His His Leu

290 295 300 <210> 3557 <211> 960 <212> DNA <213> Felis catus <400> 3557

tcactgggtg aagcatttct gactcaccaa gtttctcaca gcagccttca cgtccttgtt 60 cctcaggctg tagatgatgg ggttgagcat cggggtcacc accccataga agagggagat 120 gagcttgtct gaaaggtcct gcttgtctgc ccccaggggg tccttggatt tgggcttccc 180 atacatgaaa aggatagtcc catagaagac gaccacgact gtgaggtggg cagagcaggt 240 ggagaaggcc tttttcctcc cctcagctga agggatcctc aagatagtgg tgaggatgaa 300 gacgtaggaa acaaagatga acagaactgg gacccccagg aagatcacat ttgtcactcc 360 catactgatc acattgatgg agatgtcagc acaggccaac ttcaggacag ccaggatctc 420 acaggtaaag tggttgatga tgttgttccc acagaaggga agtctcattg caagggacgt 480 ttgaaccatg gaggcagcac ttccagctgc ccaggagctg gcagccatgg gcatataggt 540 ctccttgctc atgaccacag ggtacctaag ggggttacaa atggccacat aacgatcaaa 600 tgccatcatg cccagaagca cacactctgt ggctcccatg gcgaaggaaa gaaacatttg 660 cacagcacag gctgagaagg gtacagtttt cctgggggtc aggaagctgt cgagaatgag 720 ggggactgag gaggttgtat agcagatgtc caggaaggag aggttcccca ggaagaagta 780 catgggcgtg tgcaggcggg agacagacac agtgaccagg atgaggaccc cattgcccag 840 caggatcacc aagtacatca ggaggatgag cacaaagaac gttttctcta gctttgggtg 900 ggccgagagt cccaggagaa taaactccgc cacagaggca gtctggttga cactttccat 960

Page 3982

069269_0225_SL.TXT <210> 3558 <211> 319 <212> PRT <213> Felis catus

<400> 3558 Phe Ile Leu Leu 15 Met 1 Glu Ser Val Asn Gln Thr Ala 5 Ser Val 10 Ala Glu Gly Leu Ser Ala His Pro Lys Leu Glu Lys Thr Phe Phe Val Leu Ile 20 25 30 Leu Leu Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu 35 40 45 Val Thr Val Ser Val Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro 65 70 75 80 Leu Ile Leu Asp Ser Phe Leu Thr Pro Arg Lys Thr Val Pro Phe Ser 85 90 95 Ala Cys Ala Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu 100 105 110 Cys Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Pro Val Val Met Ser Lys Glu Thr Tyr Met Pro 130 135 140 Met Ala Ala Ser Ser Trp Ala Ala Gly Ser Ala Ala Ser Met Val Gln 145 150 155 160 Thr Ser Leu Ala Met Arg Leu Pro Phe Cys Gly Asn Asn Ile Ile Asn 165 170 175 His Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp 180 185 190

Page 3983

069269_0225_SL.TXT

Ile Ser Ile 195 Asn Val Ile Ser Met 200 Gly Val 210 Pro Val Leu Phe Ile 215 Phe Thr 225 Ile Leu Arg Ile Pro 230 Ser Ala Thr Cys Ser Ala His 245 Leu Thr Val Leu Phe Met Tyr 260 Gly Lys Pro Lys Lys Gln Asp 275 Leu Ser Asp Lys Leu 280 Thr Pro 290 Met Leu Asn Pro Ile 295 Ile Lys 305 Ala Ala Val Arg Asn 310 Leu Val

Gly Val Thr Asn Val 205 Ile Phe Leu Val Ser Tyr Val 220 Phe Ile Leu Thr Glu Gly Arg 235 Lys Lys Ala Phe Ser 240 Val Val 250 Val Phe Tyr Gly Thr 255 Ile Ser 265 Lys Asp Pro Leu Gly 270 Ala Asp Ile Ser Leu Phe Tyr 285 Gly Val Val Tyr Ser Leu Arg 300 Asn Lys Asp Val Ser Gln Lys 315 Cys Phe Thr Gln

<210> 3559 <211> 954 <212> DNA <213> Felis catus <400> 3559 ctaggcaaag catttctgac tcaccagagt gagactgtag atgatggggt tgagcatggg cttgtctgaa aggtcctgct tatctgcccc catgaaaaga atggtcccat agaagatgac gaaagccttt ttcctcccct cagctgaggg ataagagcca gagatgaaca gaactgggac cttcacagcg accttcacat gcttgtttct agtcagcact ccatagaaga gggatataag cagggggtcc ttggatttgg gctttgcgta caccacagtg aggtgggcag agcaggtgga gatcctcagg atggtagcaa tgatgaagac ccccaggaag atcacattgg ctacccccat

120

180

240

300

360

Page 3984

069269_0225_SL.TXT

actgatcaca ttgatggaga tgtcagcaca ggccaacttc aggacagcca ggatctcaca 420 ggtgaagtgg ttgatgacat tgtccccaca gaagggtaat tgtactgcaa gagagatctg 480 caccaaggag ttggctccac cagccaccca ggagctgata gccatgggca catagacagc 540 cttgctcatg accacagggt acctcagggg gttacagatg gccacatagc gatcaaatgc 600 catcatgccc agaagcacac actctgtggc tcccatggca aaggagagga acatctgcat 660 ggcacagcct gagaaggaga tggttttcct gggagtgagg aagccgtcca ggactagagg 720 aactgaagag gttgtgtagc agatgtccag gaaggagagg ttccccagga agaagtacat 780 gggcgtgtgc aggcgggagt caaggatggt caccaggatg aggaccccat tgcccagcag 840 gatcaccagg tacatcaaca ggatgaacac aaaaaacatt ttctcaagct ttggctgatc 900 tgacagcccc agcaagacaa atcccgctac <210> 3560 <211> 317 <212> PRT <213> Felis catus <400> 3560 aacagattgg ttgcccactt ccat 954 Met Glu Val Gly Asn Gln Ser Val Val Ala Gly Phe Val Leu Leu Gly 1 5 10 15 Leu Ser Asp Gln Pro Lys Leu Glu Lys Met Phe Phe Val Phe Ile Leu 20 25 30 Leu Met Tyr Leu Val Ile Leu Leu 35 40 Gly Asn Gly Val Leu Ile Leu Val 45 Thr Ile Leu Asp Ser Arg Leu His 50 55 Thr Pro Met Tyr Phe Phe Leu Gly 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro Leu 65 70 75 80 Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Ala Met Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys

Page 3985

100

069269_0225_SL.TXT 105 110

Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Val Tyr Val Pro Met 130 135 140 Ala Ile Ser Ser Trp Val Ala Gly Gly Ala Asn Ser Leu Val Gln Ile 145 150 155 160 Ser Leu Ala Val Gln Leu Pro Phe Cys Gly Asp Asn Val Ile Asn His 165 170 175 Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Val Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly 195 200 205 Val Pro Val Leu Phe Ile Ser Gly Ser Tyr Val Phe Ile Ile Ala Thr 210 215 220 Ile Leu Arg Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Val Ile Phe Tyr Gly Thr Ile Leu 245 250 255 Phe Met Tyr Ala Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys 260 265 270 Gln Asp Leu Ser Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Leu Thr 275 280 285 Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys His Val Lys 290 295 300

Val Ala Val Lys Thr Leu Val Ser Gln Lys Cys Phe Ala Page 3986

069269_0225_SL.TXT

305 310 315 <210> 3561 <211> 957 <212> DNA <213> Felis catus <400> 3561 tcactgggtg aagtgtttct gagccaccag gtacctcacc gcggtcttaa catccttgtt 60 cctcagacta tagatgatgg ggttgagcat aggagttaaa agtccataga agagggagat 120 gagcttgtct gaaaggtcct gcttgtctgc ccccaggggg tccttggatt tgggcttccc 180 atacatgaag aggatggttc catagaagat gaccacaact gtgaggtggg cagagcaggt 240 ggagaaagcc tttttcctcc cttcagctga ggggatcctc aggatagtgg tgaggatgaa 300 gatgtaggag acaaagatga acagaactgg gacccccagg aagatcacat tggccacccc 360 catactgatc acattgatgg agatgtcagc acaggccaac ttcaggacag ccaggatctc 420 acagatgaag tggttgatga cattgtcccc acagaagggt aattgtactg caagagagat 480 ctgcaccaag gagttggctc caccagccac ccaggagctg atagccatgg gcacatagac 540 agccttgctc atgaccacag ggtacctcag ggggttacag atggccacat agcgatcaaa 600 tgccatcatg cccagaagca cacactctgt ggctcccatg gcaaaggaga ggaacatctg 660 catggcacag cctgagaagg agatggtttt cctgggagtg aggaagccgt ccaggactag 720 aggaactgaa gaggttgtgt agcagatgtc caggaaggag aggttcccca ggaagaaata 780 catgggcgtg tgcaggcggg agtcaaggat ggtcaccagg atgaggaccc cattgcccag 840 caggatcacc agatacatag acaggatgag cacaaagaac gttttctcta gttttggatg 900 ggcagagagg ccaagcaaaa caaattctgt cacagcagat tggttggatg cttccat 957 <210> 3562 <211> 318 <212> PRT <213> Felis catus <400> 3562

Met Glu Ala Ser Asn Gln Ser Ala Val Thr Glu Phe Val Leu Leu Gly 1 5 10 15

Page 3987

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Leu Ser Ala His Pro 20 Lys Leu Glu Lys Thr Phe Phe Val Leu Ile Leu 25 30 Ser Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu Val 35 40 45 Thr Ile Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro Leu 65 70 75 80 Val Leu Asp Gly Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Ala Met Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 100 105 110 Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Val Met Ser Lys Ala Val Tyr Val Pro Met 130 135 140 Ala Ile Ser Ser Trp Val Ala Gly Gly Ala Asn Ser Leu Val Gln Ile 145 150 155 160 Ser Leu Ala Val Gln Leu Pro Phe Cys Gly Asp Asn Val Ile Asn His 165 170 175 Phe Ile Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Val Ile Ser Met Gly Val Ala Asn Val Ile Phe Leu Gly 195 200 205 Val Pro Val Leu Phe Ile Phe Val Ser Tyr Ile Phe Ile Leu Thr Thr 210 215 220

Page 3988

Ile 225 Leu Arg Ile Pro Ser 230 Ala 069269_0225_SL.TXT Glu Gly Arg Lys Lys Ala 235 Phe Ser Thr 240 Cys Ser Ala His Leu Thr Val Val Val Ile Phe Tyr Gly Thr Ile Leu 245 250 255 Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp Lys 260 265 270 Gln Asp Leu Ser Asp Lys Leu Ile Ser Leu Phe Tyr Gly Leu Leu Thr 275 280 285 Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Thr Ala Val Arg Tyr Leu Val Ala Gln Lys His Phe Thr Gln 305 310 315

<210> 3563 <211> 945 <212> DNA <213> Felis catus <400> 3563

atggacaggt tcaaccagac ctcccctgtg gtggggttca ttctcctggg actctcagcc 60 catccaaggc tggagaaaac gttctttgtg ctcatcctgt ctatgtatct ggtgatcctg 120 ctgggcaatg gggtcctcat cctggtgacc atccttgact cccacctgca cacgcccatg 180 tacttcttcc tggggaacct ctccttcctg gacatctgct acacaacctc ctctgtcccc 240 ctcattctcg acagcttcct gacccccagg aaaaccatct ctttctcagc ctgttttggg 300 cagatgtttc tctcctttgc catgggagct acagagtgtg tgcttctggg catgatggca 360 tttgatcgct atgtggccat ctgtaacccc ctgagatact ctgtggtcat gaacaaggct 420 atatacatac ccatggctgc tggctcctgg gcagctggta tcaccaactc tgtagttcag 480 acatcccagg ctatgaggct gcccttctgt ggggacaatg tcatcaacca cttcacctgt 540 gagatcctgg ctgtcctgaa gttggcctgt gctgacattt ctatgaatgt gatcagcatg 600 gttgtggcta atgtgatttt cctgggggtc ccagttctgt tcatttttgt ctcttatgta 660

Page 3989

069269_0225_SL.TXT ttcatcattg ctaccatcct gaggatcccc tcagctgagg ggaagaaaaa ggccttctcc acctgctctg cccacctcac agttgtggtc gtcttctatg gaaccatcct cttcatgtat gggaagccca aatccaagga ccccctgggg gcagacaagc aggacctttc agataagctc acctcccttt tctatggggt ggtgaccccc atgctcaacc ccatcatcta cagcctaagg aacaaggatg tgaaggctgc cgtgaagaac ctggtacatc aataa

720

780

840

900

945 <210> 3564 <211> 314 <212> PRT <213> Felis catus <400> 3564

Met Asp Arg 1 Phe Asn Gln Thr Ser 5 Pro Val Val Gly Phe Ile Leu Leu 10 15 Gly Leu Ser Ala His Pro Arg Leu Glu Lys Thr Phe Phe Val Leu Ile 20 25 30 Leu Ser Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Val Leu Ile Leu 35 40 45 Val Thr Ile Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu 50 55 60 Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Ser Ser Val Pro 65 70 75 80 Leu Ile Leu Asp Ser Phe Leu Thr Pro Arg Lys Thr Ile Ser Phe Ser 85 90 95 Ala Cys Phe Gly Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu 100 105 110 Cys Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys 115 120 125 Asn Pro Leu Arg Tyr Ser Val Val Met Asn Lys Ala Ile Tyr Ile Pro 130 135 140

Page 3990

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Met Ala Ala 145 Gly Ser Trp Ala Ala Gly Ile Thr Asn Ser Val Val Gln 150 155 160 Thr Ser Gln Ala Met Arg Leu Pro Phe Cys Gly Asp Asn Val Ile Asn 165 170 175 His Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp 180 185 190 Ile Ser Met Asn Val Ile Ser Met Val Val Ala Asn Val Ile Phe Leu 195 200 205 Gly Val Pro Val Leu Phe Ile Phe Val Ser Tyr Val Phe Ile Ile Ala 210 215 220 Thr Ile Leu Arg Ile Pro Ser Ala Glu Gly Lys Lys Lys Ala Phe Ser 225 230 235 240 Thr Cys Ser Ala His Leu Thr Val Val Val Val Phe Tyr Gly Thr Ile 245 250 255 Leu Phe Met Tyr Gly Lys Pro Lys Ser Lys Asp Pro Leu Gly Ala Asp 260 265 270 Lys Gln Asp Leu Ser Asp Lys Leu Thr Ser Leu Phe Tyr Gly Val Val 275 280 285 Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val 290 295 300 Lys Ala Ala Val Lys Asn Leu Val His Gln 305 310 <210> 3565 <211> 978 <212> DNA <213> Felis catus <400> 3565 atgtttcagg gaaatttgac atctgtaaca gtttttttcc tcctgggatt ttcccactac 60

Page 3991

069269_0225_SL.TXT

cccaaagttg aggtcattgt atttgtgctg tgcttgctga tgtacctgat caccctgctg 120 ggtaatatca ttctgatctc catcaccatc ctggattccc acctacacaa acccatgtac 180 ttcttcctca gcaacctctc ctttttagac atctggtaca cttcttctgc ttttactcca 240 atgctgacaa actttgttac aggggaaaac actatctcat tcgtagggtg tgttgctcag 300 atgtacttct ctctagctat gggtgccact gagtgtgtgc tcttgtcctt gatggcatat 360 gaccgatatg tggccatctg caaccccctg agatacccca tcataatgaa caggaaggtt 420 tgtttgcaga ttgcagctgg ttcctggttg acaggctacc tcaccaccct ggtggaaaca 480 atatttgtgc tgcagctctc tctgtgtggt cataacacca tcaatcattt tgcttgtgaa 540 attctggctg tcttgaaact ggtttgtgtg gacacctcca tggtggaatt actcatgctg 600 gtgatcacca cacttatcct tcccatgcca gtgcttctaa tttgtatatc ttatgcattc 660 attctctcca acatcctaag aattcgttca gtgggtggtc gaagcaaagc cttttcaaca 720 tgtgcagccc acctaactgt ggtggttttg ttctttggga cagctctctc catgtaccta 780 aagccctcag ctgtggattc acaggaaata gataaattta tagctttggt atatggcgga 840 ttaaccccca tgttgaatcc tatcatctat agtctacgga acaaagaggt gaaagcagct 900 atgaaaaggt tgctgattag aaatcctttt ggtactgtgt taatttctgt cctcaataat 960 atcagagcaa gcacactc 978

<210> 3566 <211> 326 <212> PRT <213> Felis catus <400> 3566

Met Phe Gln Gly Asn Leu Thr Ser Val Thr Val Phe Phe Leu Leu Gly 1 5 10 15 Phe Ser His Tyr Pro Lys Val Glu Val Ile Val Phe Val Leu Cys Leu 20 25 30 Leu Met Tyr Leu Ile Thr Leu Leu Gly Asn Ile Ile Leu Ile Ser Ile

35 40 45

Page 3992

Thr Ile 50 Leu Asp Ser His Leu 55 069269_0225_SL.TXT Phe Leu Ser His Lys Pro Met Tyr Phe 60 Asn Leu Ser Phe Leu Asp Ile Trp Tyr Thr Ser Ser Ala Phe Thr Pro 65 70 75 80 Met Leu Thr Asn Phe Val Thr Gly Glu Asn Thr Ile Ser Phe Val Gly 85 90 95 Cys Val Ala Gln Met Tyr Phe Ser Leu Ala Met Gly Ala Thr Glu Cys 100 105 110 Val Leu Leu Ser Leu Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Ile Ile Met Asn Arg Lys Val Cys Leu Gln Ile 130 135 140 Ala Ala Gly Ser Trp Leu Thr Gly Tyr Leu Thr Thr Leu Val Glu Thr 145 150 155 160 Ile Phe Val Leu Gln Leu Ser Leu Cys Gly His Asn Thr Ile Asn His 165 170 175 Phe Ala Cys Glu Ile Leu Ala Val Leu Lys Leu Val Cys Val Asp Thr 180 185 190 Ser Met Val Glu Leu Leu Met Leu Val Ile Thr Thr Leu Ile Leu Pro 195 200 205 Met Pro Val Leu Leu Ile Cys Ile Ser Tyr Ala Phe Ile Leu Ser Asn 210 215 220 Ile Leu Arg Ile Arg Ser Val Gly Gly Arg Ser Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ala His Leu Thr Val Val Val Leu Phe Phe Gly Thr Ala Leu 245 250 255

Page 3993

Ser Met Tyr Leu 260 Lys Pro Ser 069269_0225_SL.TXT Ala Val Asp Ser Gln Glu 265 Ile 270 Asp Lys Phe Ile Ala Leu Val Tyr Gly Gly Leu Thr Pro Met Leu Asn Pro Ile 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Ala Ala Met Lys Arg Leu 290 295 300 Leu Ile Arg Asn Pro Phe Gly Thr Val Leu Ile Ser Val Leu Asn Asn 305 310 315 320 Ile Arg Ala Ser Thr Leu

325 <210> 3567 <211> 958 <212> DNA <213> Felis catus <400> 3567

ttattggtta acagttttcc aattcagcaa atatttcaca gcagctttta catctttatt 60 tctcaagcta tagattatag gatttagcat gggggttact accccataaa acatggaaat 120 aagcccctct gtagcttgca aattgtcatt ccgaaggtgg tcttgagact tgggtttggc 180 atacatgaag aagatggtac cataaaatat gatcaccaca gtcagatgtg ctgaacaggt 240 ggaaaaggct ttgcgtctcc ctgtggctga gttcattctc aagatggtgt aaaggatgaa 300 catataggag aaaaaaatga ctatcagtgg aagaaccagg aatgccatat ttgaaactgc 360 tagggtaaca taattgaggg ttatatcagc acaagctagc ttaaggacag ctaatatctc 420 acataagaaa tgattgataa tattattccc acagaaaggc aactgcatgg caagagatgt 480 ttgcacaatt gagttgattc caccagagag ccatgacaca gaagccatca gtacatacac 540 caccttgctc atgatgatgg ggtatctcag agggttacag atggctacat agcgatcaaa 600 agccatcatg ccaaggagga aacactctgt tgaccccatt gcaaacccaa agaacatctg 660 cactgcacat ccagagaagg gaatgttcct tttctttgaa attaagctca ccaaagttga 720 gggaacagag gaggatgtat agcagatatc caggaaagac aggttgccca ggaagaagta 780

Page 3994

069269_0225_SL.TXT catgggggtg gtgaagacga gaatcaaaga tgcttgctat gatcaaaaca ccattgccaa ttagaatcac tagatacatt actagaatta gagaaaaaaa aatgatctca agttttgggt aaccagagag tcctagaaga atgaattctt tcacaaatgt cttgtttatc ctatccat

840

900

958 <210> 3568 <211> 260 <212> PRT <213> Felis catus

<400> 3568 Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Met Tyr 1 Phe Phe Leu 5 10 15 Ser Ser Ser Val Pro Ser Thr Leu Val Ser Leu Ile Ser Lys Lys Arg 20 25 30 Asn Ile Pro Phe Ser Gly Cys Ala Val Gln Met Phe Phe Gly Phe Ala 35 40 45 Met Gly Ser Thr Glu Cys Phe Leu Leu Gly Met Met Ala Phe Asp Arg 50 55 60 Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Pro Ile Ile Met Ser Lys 65 70 75 80 Val Val Tyr Val Leu Met Ala Ser Val Ser Trp Leu Ser Gly Gly Ile 85 90 95 Asn Ser Ile Val Gln Thr Ser Leu Ala Met Gln Leu Pro Phe Cys Gly 100 105 110 Asn Asn Ile Ile Asn His Phe Leu Cys Glu Ile Leu Ala Val Leu Lys 115 120 125 Leu Ala Cys Ala Asp Ile Thr Leu Asn Tyr Val Thr Leu Ala Val Ser 130 135 140 Asn Met Ala Phe Leu Val Leu Pro Leu Ile Val Ile Phe Phe Ser Tyr 145 150 155 160

Page 3995

069269_0225_SL.TXT

Met Phe Ile Leu Tyr 165 Thr Ile Leu Arg Met Asn Ser Ala Thr Gly Arg 170 175 Arg Lys Ala Phe Ser Thr Cys Ser Ala His Leu Thr Val Val Ile Ile 180 185 190 Phe Tyr Gly Thr Ile Phe Phe Met Tyr Ala Lys Pro Lys Ser Gln Asp 195 200 205 His Leu Arg Asn Asp Asn Leu Gln Ala Thr Glu Gly Leu Ile Ser Met 210 215 220 Phe Tyr Gly Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu 225 230 235 240 Arg Asn Lys Asp Val Lys Ala Ala Val Lys Tyr Leu Leu Asn Trp Lys 245 250 255

Thr Val Asn Gln 260

<210> 3569 <211> 954 <212> DNA <213> Felis catus <400> 3569 ttactgaata gctttttggt ttagcagata ttttacagca atttttacat ccttattcct 60 caagctatag attataggat ttagcatggg ggtcactacc ccataaaaca gagaaatgag 120 cttgtctgaa gtttgcaact tgtcgtcccc aggaaactct tgagacttgg gcttggcata 180 catgaagaag atggtaccat aaaatatgat caccacagtc agatgtgctg aacaggtgga 240 aaaggctttg cgtctccctg tggctgagtt cattctcaag atggtgtaaa ggatgaacat 300 ataggagaaa aaaatgacta tcagtggaag aaccaggaat gccatatttg atatcaccat 360 ggtgataata ttgagggata tatcagcaca agctagctta aggacagcta atatttcaca 420 tgtgaaatgg ttgataacat tattcccaca gaaaggcaac tgcatggcaa gagatgtttg 480 cacaattgag ttgattccac cagagagcca tgacacagaa gccatcagta catacaccac 540

Page 3996

069269_0225_SL.TXT

cttgctcatg atgatggggt atctcagagg gttacagatg gctacatagc gatcaaaagc 600 catcatgcca aggaggaaac actctgttga ccccattgca aacccaaaga acatctgcac 660 tgcacatcca gagaagggaa tgttcctttt ctttgaaatt aagctcacca aagttgaggg 720 aacagaggag gatgtatagc agatatccag gaaagacagg ttgcccagga agaagtacat 780 gggggtgtga agacgagaat caaagatgct tgctatgatc agaacaccgt tgccagttag 840 aatcactaga tacattacta gaattagaac aaagtacatg atctccagtt ttgggtaacc 900 ggagaatccc agaagaagaa attctgatgt aaatgtctgg ttaattttat ccat 954

<210> 3570 <211> 317 <212> PRT <213> Felis catus

<400> 3570 Gln Thr Phe Thr Ser Glu Phe Leu Leu Leu Gly Met 1 Asp Lys Ile Asn 5 10 15 Phe Ser Gly Tyr Pro Lys Leu Glu Ile Met Tyr Phe Val Leu Ile Leu 20 25 30 Val Met Tyr Leu Val Ile Leu Thr Gly Asn Gly Val Leu Ile Ile Ala 35 40 45 Ser Ile Phe Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Ser 65 70 75 80 Thr Leu Val Ser Leu Ile Ser Lys Lys Arg Asn Ile Pro Phe Ser Gly 85 90 95 Cys Ala Val Gln Met Phe Phe Gly Phe Ala Met Gly Ser Thr Glu Cys 100 105 110 Phe Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125

Page 3997

069269_0225_SL.TXT

Pro Leu Arg Tyr Pro Ile Ile Met Ser Lys Val Val Tyr Val Leu Met 130 135 140 Ala Ser Val Ser Trp Leu Ser Gly Gly Ile Asn Ser Ile Val Gln Thr 145 150 155 160 Ser Leu Ala Met Gln Leu Pro Phe Cys Gly Asn Asn Val Ile Asn His 165 170 175 Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Leu Asn Ile Ile Thr Met Val Ile Ser Asn Met Ala Phe Leu Val 195 200 205 Leu Pro Leu Ile Val Ile Phe Phe Ser Tyr Met Phe Ile Leu Tyr Thr 210 215 220 Ile Leu Arg Met Asn Ser Ala Thr Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe 245 250 255 Phe Met Tyr Ala Lys Pro Lys Ser Gln Glu Phe Pro Gly Asp Asp Lys 260 265 270 Leu Gln Thr Ser Asp Lys Leu Ile Ser Leu Phe Tyr Gly Val Val Thr 275 280 285 Pro Met Leu Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Ile Ala Val Lys Tyr Leu Leu Asn Gln Lys Ala Ile Gln 305 310 315

<210> 3571 <211> 960

Page 3998

<212> DNA <213> Felis catus 069269_0225_SL.TXT <400> 3571 atggaaagga ccaatgattc catgctgaca gaatttgtcc ttgttgggct ttctgcccac 60 ccaaagctcc agacagtttt ctttgcgcta gttttgtgga tgtacctgat gatccttctg 120 ggaaatggaa tccttatctc agtaatcatc tgtgattctc acttgcacac ccccatgtat 180 ttcttcctct gtaatctttc cttcctggac atttgttaca caagctcctc tgtcccacta 240 attcttgaca gttttctgac aggaaggaaa aaggtttcct tttctgggtg catggtgcaa 300 atgtttctct cctttgccat gggggccaca gagtgtgtgc ttctaggtat gatggcactc 360 gaccgctatg tagccatctg ctacccactg agatactctg tcatcatgag caaaaatgcc 420 tacctgccca tggcagctgg atcctgggtc actgggcttg tggactcagt ggtgcagaca 480 tctctcgcaa tgcagttacc attctgtact agtaatgtca ttaaccattt tgtctgtgaa 540 attctagcta tcctaaaact ggcttgtgct gatatttcaa tcaatgtgat cagcatggca 600 gggtcaaatc tgattgttct ggttattcca ctgctagtaa tttctatatc ttacattttt 660 attgtcacca ctatattgag gatcccctcc accaaaggaa aacgtaaggc cttctccacc 720 tgctccgccc acttaacagt agtgattata ttctatggaa ctatcttctt catgtacgca 780 aagcccaagt ctaaaagttc tgttgatgct gataatcaag acatcattga ggccctcatc 840 tctctcttct atggagtaat ggcccccatg ctcaatcctc tcatctatag tctgaggaac 900 aaggatgtaa aggctgcagt gaagaacatg gtgggtagaa aaaactctga tggaatctga 960

<210> 3572 <211> 319 <212> PRT <213> Felis catus

<400> 3572 Met Glu Arg Thr Asn Asp Ser Met Leu Thr Glu Phe Val Leu Val Gly 1 5 10 15 Leu Ser Ala His Pro Lys Leu Gln Thr Val Phe Phe Ala Leu Val Leu 20 25 30 Trp Met Tyr Leu Met Ile Leu Leu Gly Asn Gly Ile Leu Ile Ser Val Page 3999

069269_0225_SL.TXT 40 45

Ile Ile 50 Cys Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Cys 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Val Pro Leu 65 70 75 80 Ile Leu Asp Ser Phe Leu Thr Gly Arg Lys Lys Val Ser Phe Ser Gly 85 90 95 Cys Met Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 100 105 110 Val Leu Leu Gly Met Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Tyr 115 120 125 Pro Leu Arg Tyr Ser Val Ile Met Ser Lys Asn Ala Tyr Leu Pro Met 130 135 140 Ala Ala Gly Ser Trp Val Thr Gly Leu Val Asp Ser Val Val Gln Thr 145 150 155 160 Ser Leu Ala Met Gln Leu Pro Phe Cys Thr Ser Asn Val Ile Asn His 165 170 175 Phe Val Cys Glu Ile Leu Ala Ile Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Val Ile Ser Met Ala Gly Ser Asn Leu Ile Val Leu Val 195 200 205 Ile Pro Leu Leu Val Ile Ser Ile Ser Tyr Ile Phe Ile Val Thr Thr 210 215 220 Ile Leu Arg Ile Pro Ser Thr Lys Gly Lys Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Phe

Page 4000

069269_0225_SL.TXT

245 250 255

Phe Met Tyr Ala Lys Pro Lys Ser Lys 265 Ser Ser Val Asp Ala 270 Asp Asn 260 Gln Asp Ile Ile Glu Ala Leu Ile Ser Leu Phe Tyr Gly Val Met Ala 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Ala Ala Val Lys Asn Met Val Gly Arg Lys Asn Ser Asp Gly Ile 305 310 315

<210> 3573 <211> 913 <212> DNA <213> Felis catus <400> 3573

atggacagga tgaactggac agagattgag ttcattctgc agggactttc tgagtacccc 60 aaagtgaaaa aactcctttt cgtcatgtgc ttgatgatgt acctggtgat cctgctaggg 120 aacagcatct tgatcatact aactctccta gattcccgcc tccatacgcc catgtacttc 180 ttccttggta atctttcttt cctaaatatt tgttacacgt cctcctttat ccccttaatg 240 ttaattcact tcctatcaca gaagaaaacc atctccttcc ttagatgtgt tgttcagatg 300 tctgtctcct acactatggg gtccaccgag tgcgtgcttc tagcagtgat ggcatatgac 360 cgttatgtgg ccatctgtaa ccctctgaga taccccatca tcatgagcaa ggcactttgt 420 attcagatgg cagccctctc ctggggactg ggctttctca attcactgat taaaaactat 480 acttgcaata cagttgccct tctgtggaaa aaatgtcatg aaccactttg tgaaatattg 540 gcctttgtta agctggcttg tgcacataat actttgactg agattgctat aatgttgggc 600 aatgtaatat ttttgtttat tccattattg taaatttgta tcccctacat tttcatcctt 660 tctactgtac taagaatcaa ttcagcagaa ggaagaaaaa aggccttctg tacctgttca 720 gcccacttaa cagtagtgac cttgttttat gggacaatcc tcttcatata catgaagcca 780 aagtccaaag actttgctgt tgacaaatcg actgctctat ggagtagtca ctcccatgcc 840

Page 4001

069269_0225_SL.TXT aatgatatgc ctatcatcta tagcctgggg aacacagagg tgttggagct gtgagaaaaa tgatgagtag aca

900

913 <210> 3574 <211> 210 <212> PRT <213> Felis catus

<400> 3574 Trp Thr Glu Ile Glu Phe Ile Leu Gln Gly Leu Met Asp 1 Arg Met Asn 5 10 15 Ser Glu Tyr Pro Lys Val Lys Lys Leu Leu Phe Val Met Cys Leu Met 20 25 30 Met Tyr Leu Val Ile Leu Leu Gly Asn Ser Ile Leu Ile Ile Leu Thr 35 40 45 Leu Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn 50 55 60 Leu Ser Phe Leu Asn Ile Cys Tyr Thr Ser Ser Phe Ile Pro Leu Met 65 70 75 80 Leu Ile His Phe Leu Ser Gln Lys Lys Thr Ile Ser Phe Leu Arg Cys 85 90 95 Val Val Gln Met Ser Val Ser Tyr Thr Met Gly Ser Thr Glu Cys Val 100 105 110 Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125 Leu Arg Tyr Pro Ile Ile Met Ser Lys Ala Leu Cys Ile Gln Met Ala 130 135 140 Ala Leu Ser Trp Gly Leu Gly Phe Leu Asn Ser Leu Ile Lys Asn Tyr 145 150 155 160

Page 4002

069269_0225_SL.TXT Thr Cys Asn Thr Val Ala Leu Leu Trp Lys Lys Cys His Glu Pro Leu 165 170 175

Cys Glu Ile Leu Ala Phe Val Lys Leu Ala Cys Ala His Asn Thr Leu 180 185 190

Thr Glu Ile Ala Ile Met Leu Gly Asn Val Ile Phe Leu Phe Ile Pro 195 200 205

Leu Leu 210 <210> 3575 <211> 910 <212> DNA <213> Felis catus <400> 3575

atggacagga tgaactggac agagattgag ttcattctgc agggactttc tgagtacccc 60 aaagtggaaa aactcctttt cgtcatgtgc ttgatgatgt acctggtgat cctgctgggg 120 aacagcccct tgatcatact aactctcctg gactcccacc tccatacacc catgtacttc 180 ttccttggta atctttcctt cctagatatt tgttacacat cctcctttat cccctcaatg 240 ttgattcact tcctatcaca gaaaaaaacc atctccttcc ttagatgtgt tgttcagatg 300 tctgtctcct acactatggg gtccacagag tgcgtgcttc tagcagtgat ggcatatgac 360 cgttacatgg ccatctgtaa ccctctgaga taccccatca tcatgagcaa ggcactttgc 420 attcagatgg cagccctctc ctggggactg ggctttctca attcactgac agaaactata 480 cttgcaatac agttgccctt ctgtggaaaa aatgtcatta accactttgt ttgtgaaata 540 ctggcctttg tcaaactggc ttgcgcagat atttccttga atgagattgc tataatgttg 600 ggcaatgtaa tatttttgtt ttctccatta ttgttaattt gtatctccta cattttcatc 660 ctttctaatg tactaagaat caattcagca gaaggaagaa aaaaggcctt ttctacctgt 720 tcagcccact taacagtagt gactgtgttt tatgggacaa tcctcttcat gtatatgaag 780 ccaaagtcca aagactctgc tgctgacaaa ctgattgctc tgttctatgg agtagtcact 840 cccatgctca atcctatcat ctatagcctg aggaatacag aggtgcttgg agctatgaga 900

Page 4003

069269_0225_SL.TXT aaattgatga

910 <210> 3576 <211> 304 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (304)..(304) <223> Any amino acid

<400> 3576 Met Asp Arg 1 Met Asn Trp Thr Glu Ile Glu Phe Ile Leu Gln Gly 15 Leu 5 10 Ser Glu Tyr Pro Lys Val Glu Lys Leu Leu Phe Val Met Cys Leu Met 20 25 30 Met Tyr Leu Val Ile Leu Leu Gly Asn Ser Pro Leu Ile Ile Leu Thr 35 40 45 Leu Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn 50 55 60 Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Phe Ile Pro Ser Met 65 70 75 80 Leu Ile His Phe Leu Ser Gln Lys Lys Thr Ile Ser Phe Leu Arg Cys 85 90 95 Val Val Gln Met Ser Val Ser Tyr Thr Met Gly Ser Thr Glu Cys Val 100 105 110 Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Asn Pro 115 120 125 Leu Arg Tyr Pro Ile Ile Met Ser Lys Ala Leu Cys Ile Gln Met Ala 130 135 140 Ala Leu Ser Trp Gly Leu Gly Phe Leu Asn Ser Leu Thr Glu Thr Ile

Page 4004

069269_0225_SL.TXT

145 150 155 160 Leu Ala Ile Gln Leu Pro Phe Cys Gly Lys Asn Val Ile Asn His Phe 165 170 175 Val Cys Glu Ile Leu Ala Phe Val Lys Leu Ala Cys Ala Asp Ile Ser 180 185 190 Leu Asn Glu Ile Ala Ile Met Leu Gly Asn Val Ile Phe Leu Phe Ser 195 200 205 Pro Leu Leu Leu Ile Cys Ile Ser Tyr Ile Phe Ile Leu Ser Asn Val 210 215 220 Leu Arg Ile Asn Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ala His Leu Thr Val Val Thr Val Phe Tyr Gly Thr Ile Leu Phe 245 250 255 Met Tyr Met Lys Pro Lys Ser Lys Asp Ser Ala Ala Asp Lys Leu Ile 260 265 270 Ala Leu Phe Tyr Gly Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Thr Glu Val Leu Gly Ala Met Arg Lys Leu Met Xaa 290 295 300

<210> 3577 <211> 971 <212> DNA <213> Felis catus <400> 3577

tgtccctttc ccatttactt gttaaacata cttcttctca gtaagtgttt tactgcctcc 60 ttaacatctt tgttcctaag actgtatatt aaaggattca tcataggagt tacaatccca 120 tagaacaggg atataagttt gtcagtagca tccaagtcct ctgaattaag tgtgtcttta 180 gacttgggct tcatgtacat gaagagaatg gttccataga atattatcac cacagtcaga Page 4005 240

069269_0225_SL.TXT tgggctgagc acgtggagta aactttgctt ctcccctcag aagagcgaat tttgaggatg ctgacaatga ttaatgtgta agagataatg attaataaca gtggtgtcaa tataaacagt gttgtgccca cgagcatgat gaactcgttg cctgagatgt cagcacaggc cagtttcatg atagccagaa tttcacagga gagatgattg atgacattat tcccacagaa aggcaactgt actacaaatg cggtctgtac tgcagagttg atgactccta tgatccagga cccaactgcc atgggcacat aggaatcctt gctcatgatg acaggatatc ttagagggtt gcagatagcc acataccggt caaaggccat catgcccagg agcacacact ctgttgtccc catggccaag ccgaggaaca tctgtattgc acagccagag aaggatatgg tctttctttc tgagaggaag ctcaccagaa tggagggaat ggaggtggtg gtgtagcaga tgtccaagaa ggagaggttc cccaggaaga agtacatagg ggtgtgaagg tgggggtccc agatgctgat taaaataagg gtgccattgc ccagaaggat gacaacatac attattaaga ttagtgcaaa aaagagtagc tcaagccttg ggtaatcaga aagccccttg agaaagaatt ccaccagaat ggtttgattt tcccattcca t <210> 3578 <211> 318 <212> PRT <213> Felis catus

300

360

420

480

540

600

660

720

780

840

900

960

971

<400> 3578 Met Glu Trp Glu 1 Asn 5 Gln Thr Ile Leu Val Glu Phe Phe Leu Lys Gly 10 15 Leu Ser Asp Tyr Pro Arg Leu Glu Leu Leu Phe Phe Ala Leu Ile Leu 20 25 30 Ile Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile 35 40 45 Ser Ile Trp Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser 65 70 75 80

Page 4006

069269_0225_SL.TXT

Ile Leu Val Ser Phe 85 Leu Ser Glu Arg Lys Thr Ile Ser Phe Ser Gly 90 95 Cys Ala Ile Gln Met Phe Leu Gly Leu Ala Met Gly Thr Thr Glu Cys 100 105 110 Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Ile Met Ser Lys Asp Ser Tyr Val Pro Met 130 135 140 Ala Val Gly Ser Trp Ile Ile Gly Val Ile Asn Ser Ala Val Gln Thr 145 150 155 160 Ala Phe Val Val Gln Leu Pro Phe Cys Gly Asn Asn Val Ile Asn His 165 170 175 Leu Ser Cys Glu Ile Leu Ala Ile Met Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Gly Asn Glu Phe Ile Met Leu Val Gly Thr Thr Leu Phe Ile Leu 195 200 205 Thr Pro Leu Leu Leu Ile Ile Ile Ser Tyr Thr Leu Ile Ile Val Ser 210 215 220 Ile Leu Lys Ile Arg Ser Ser Glu Gly Arg Ser Lys Val Tyr Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 245 250 255 Phe Met Tyr Met Lys Pro Lys Ser Lys Asp Thr Leu Asn Ser Glu Asp 260 265 270 Leu Asp Ala Thr Asp Lys Leu Ile Ser Leu Phe Tyr Gly Ile Val Thr 275 280 285

Page 4007

069269_0225_SL.TXT

Pro Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300

Glu Ala Val Lys His Leu Leu Arg Arg Ser Met Phe Asn Lys 305 310 315 <210> 3579 <211> 963 <212> DNA <213> Felis catus <400> 3579

cttttccatt cacttgctaa agaaacttct gttaaataga tgtttcactg tctcctttac 60 atccttgttt ctgagactgt agattaaagg attcatcatg ggagtcatca ctccatagaa 120 catggatatc aatttgtcag tggcatacaa gtcctctgaa ttaagtgtct ctttagactt 180 gggcttcatg tacatgaaga gaatggttcc atagaatatt atcaccacaa tcaggtgggc 240 tgagcaggtg gagaaagctt tgcttctccc ctcagaagta cggatcttca ggatgctaga 300 gatgattaat gagtaagata tgacaatcaa aagcaggggc atcagtgtga acaatgttgt 360 ggccacaacc atgatgaatt cattgcctga gatgtcagca caggccagtt tcatgacagc 420 cagaatttca caagagaaat gattgatgtt attcctacag aagttcaatt gtatcacaaa 480 tgcagtttgc actgcagagt tgataatccc agcaaaccag gacccagctg ccatggacac 540 ataggaatcc ttgctcatga tgacaggata tcttagaggg ttgcagatag ccacataccg 600 gtcaaaggcc atcatgccca ggagcacaca ctctgttgtc cccatggcca tgccaaggaa 660 catctgtatt gcacagccag agaaggatat ggtctttctt tctgagagga agtttaccag 720 agtggaggga atggaggtgg tggtgtagca gatgtccaag aaggagaggt tccccaggaa 780 gaagtacata ggggtgtgaa ggtgggggtc ccagatgctg attaaaataa gggtgccatt 840 gcccagaagg atgacaacat acattattaa gattagtgca aaaaagagta gctcaagcct 900 tgggtaatca gaaagcccct tgagaaagaa ttccaccaga atggtttgat tttcccattc 960

cat 963 <210> 3580

Page 4008

069269_0225_SL.TXT <211> 317 <212> PRT <213> Felis catus

<400> 3580 Phe Leu Lys Gly 15 Met 1 Glu Trp Glu Asn Gln Thr Ile 5 Leu Val 10 Glu Phe Leu Ser Asp Tyr Pro Arg Leu Glu Leu Leu Phe Phe Ala Leu Ile Leu 20 25 30 Ile Met Tyr Val Val Ile Leu Leu Gly Asn Gly Thr Leu Ile Leu Ile 35 40 45 Ser Ile Trp Asp Pro His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Thr Thr Ser Ile Pro Ser 65 70 75 80 Thr Leu Val Asn Phe Leu Ser Glu Arg Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Ala Ile Gln Met Phe Leu Gly Met Ala Met Gly Thr Thr Glu Cys 100 105 110 Val Leu Leu Gly Met Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Val Ile Met Ser Lys Asp Ser Tyr Val Ser Met 130 135 140 Ala Ala Gly Ser Trp Phe Ala Gly Ile Ile Asn Ser Ala Val Gln Thr 145 150 155 160 Ala Phe Val Ile Gln Leu Asn Phe Cys Arg Asn Asn Ile Asn His Phe 165 170 175 Ser Cys Glu Ile Leu Ala Val Met Lys Leu Ala Cys Ala Asp Ile Ser 180 185 190

Page 4009

069269_0225_SL.TXT

Gly Asn Glu Phe Ile Met Val Val Ala Thr Thr Leu Phe Thr Leu Met 195 200 205 Pro Leu Leu Leu Ile Val Ile Ser Tyr Ser Leu Ile Ile Ser Ser Ile 210 215 220 Leu Lys Ile Arg Thr Ser Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ala His Leu Ile Val Val Ile Ile Phe Tyr Gly Thr Ile Leu Phe 245 250 255 Met Tyr Met Lys Pro Lys Ser Lys Glu Thr Leu Asn Ser Glu Asp Leu 260 265 270 Tyr Ala Thr Asp Lys Leu Ile Ser Met Phe Tyr Gly Val Met Thr Pro 275 280 285 Met Met Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Glu 290 295 300 Thr Val Lys His Leu Phe Asn Arg Ser Phe Phe Ser Lys

305 310 315 <210> 3581 <211> 939 <212> DNA <213> Felis catus <400> 3581

atggacagga cgaactggac agagattgag ttcattctgc agggactttc tgagtacccc 60 aaagtggaaa aactcctttt cgtcatgtgc ttgatgatgt acctggtgat cctgctgggg 120 aacagcactt tgatcatact aattctcctg gattcccggc tccatacgcc catgtacttc 180 ttcctcggta atctttccct cctagacatt tgttacacat cctcctttac cccctcagtg 240 ttgattcact tcctatcaca gaaaaaaacc atctccttca ctaggtgtgt tgttcagatg 300 tctgtctcct acacaatggc atgcacagaa tgcgtgctct tagcagtgat ggcatatgac 360 cgttacgtgg ctatctgtaa ccctctgaga taccccatca tcatgagcaa ggcactttgt 420

Page 4010

069269_0225_SL.TXT

attcagatgg cagccctctc ctggggaatg ggctttctca attcactgac agaaactata 480 cttgcaatac ggttgccctt ttgtggaaaa aatgtcatta accactttgt ttgtgaaata 540 atggcttttg tcaagctggc ttgtgcagat atttccttga atgagattgc tataatgttg 600 ggcaatgtaa tatttttgta tattccatta ttgttaattt gcatctccta cattttcatc 660 ctatctactg tactaaaaat gaattcagca gaaggaagaa aaaaagcttt ttctacctgt 720 tcagcccact taacagtagt gaccatgttt tatgggacaa tcctcttcat atatatgaag 780 ccaaagtcca aagactctgc tattgacaaa ctgattgctc tgttctatgg cgtagtcact 840 cccatgctca atcctatcat ctatagcctg aggaacacag aggtgcttgg agctttgaga 900 aaattgatga gtagacactg tttctggaga aaaggatga 939

<210> 3582 <211> 312 <212> PRT <213> Felis catus

<400> 3582 Trp Thr Glu Ile Glu Phe Ile Leu Gln Gly Leu Met Asp 1 Arg Thr Asn 5 10 15 Ser Glu Tyr Pro Lys Val Glu Lys Leu Leu Phe Val Met Cys Leu Met 20 25 30 Met Tyr Leu Val Ile Leu Leu Gly Asn Ser Thr Leu Ile Ile Leu Ile 35 40 45 Leu Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Gly Asn 50 55 60 Leu Ser Leu Leu Asp Ile Cys Tyr Thr Ser Ser Phe Thr Pro Ser Val 65 70 75 80 Leu Ile His Phe Leu Ser Gln Lys Lys Thr Ile Ser Phe Thr Arg Cys 85 90 95 Val Val Gln Met Ser Val Ser Tyr Thr Met Ala Cys Thr Glu Cys Val 100 105 110

Page 4011

069269_0225_SL.TXT

Leu Leu Ala 115 Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 120 125 Leu Arg Tyr Pro Ile Ile Met Ser Lys Ala Leu Cys Ile Gln Met Ala 130 135 140 Ala Leu Ser Trp Gly Met Gly Phe Leu Asn Ser Leu Thr Glu Thr Ile 145 150 155 160 Leu Ala Ile Arg Leu Pro Phe Cys Gly Lys Asn Val Ile Asn His Phe 165 170 175 Val Cys Glu Ile Met Ala Phe Val Lys Leu Ala Cys Ala Asp Ile Ser 180 185 190 Leu Asn Glu Ile Ala Ile Met Leu Gly Asn Val Ile Phe Leu Tyr Ile 195 200 205 Pro Leu Leu Leu Ile Cys Ile Ser Tyr Ile Phe Ile Leu Ser Thr Val 210 215 220 Leu Lys Met Asn Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ala His Leu Thr Val Val Thr Met Phe Tyr Gly Thr Ile Leu Phe 245 250 255 Ile Tyr Met Lys Pro Lys Ser Lys Asp Ser Ala Ile Asp Lys Leu Ile 260 265 270 Ala Leu Phe Tyr Gly Val Val Thr Pro Met Leu Asn Pro Ile Ile Tyr 275 280 285 Ser Leu Arg Asn Thr Glu Val Leu Gly Ala Leu Arg Lys Leu Met Ser 290 295 300 Arg His Cys Phe Trp Arg Lys Gly

305 310

Page 4012

069269_0225_SL.TXT <210> 3583 <211> 955 <212> DNA <213> Felis catus <400> 3583 cctctgagga gcatttctga cacagcatat tcttcacagc ttccttcaca tctttgttcc 60 tcaaactata gatgagggga ttgagcatag gtgtcacaac tccatagaag agagagatga 120 ttttgtctgt gacttgtact ttgtctgtac cagagaagtc tttagcctta ggttttgcat 180 acatgaagag gatggttcca tagaatataa tcaccacagt taggtgggcg gagcaggtgg 240 agaaggcttt gcgcttcccc tctgcagaag gaatcttcag gatagtggag agaatgaaaa 300 tataggaaac aaaaatgaaa agtactggga ccacaagaaa gataacatta gcaataacca 360 tgctaataat atttatggag atatcagcac aagccaattt taagacagcc aagatttcac 420 aagtaaaatg attaatgaca ttatccccac agaaaggaag ccgcattgca agagaggttt 480 gcaacacaga attgacaccc cctgcaatcc aggacccagc agccatggac atgtatgaag 540 tcttgctcat aataacggag tatctcagag ggttacagat ggccgcatag cggtcaaatg 600 ccatcatgct cagaaggaca cactctgtgg ctcccatagc aaaggagaga aacatttgca 660 ctccacaccc agagaaggaa atggttttct gtgaagttaa gaagctgctg agaaataggg 720 gaatagaaga actggtatag caaatgtcca agaatgataa gttactgagg aaaaagtaca 780 tgggggtgtg caagtgggag tcacagacac ttacaatgat gatgattcca tttcccagca 840 ggataaccag gtacatacac agcaccatca caaagtaaat ggcctcaagc tctggatagc 900 cagaaagccc cagtaggaca aattctgtca cagaagactg attggtcttt cccat 955 <210> 3584 <211> 319 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (319)..(319) <223> Any amino acid

Page 4013

069269_0225_SL.TXT

<400> 3584 Asn Gln Ser Ser Val Thr Glu Phe Val Leu Leu 15 Gly Met 1 Gly Lys Thr 5 10 Leu Ser Gly Tyr Pro Glu Leu Glu Ala Ile Tyr Phe Val Met Val Leu 20 25 30 Cys Met Tyr Leu Val Ile Leu Leu Gly Asn Gly Ile Ile Ile Ile Val 35 40 45 Ser Val Cys Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Ile Pro Leu 65 70 75 80 Phe Leu Ser Ser Phe Leu Thr Ser Gln Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Gly Val Gln Met Phe Leu Ser Phe Ala Met Gly Ala Thr Glu Cys 100 105 110 Val Leu Leu Ser Met Met Ala Phe Asp Arg Tyr Ala Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Ser Val Ile Met Ser Lys Thr Ser Tyr Met Ser Met 130 135 140 Ala Ala Gly Ser Trp Ile Ala Gly Gly Val Asn Ser Val Leu Gln Thr 145 150 155 160 Ser Leu Ala Met Arg Leu Pro Phe Cys Gly Asp Asn Val Ile Asn His 165 170 175 Phe Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Ile 180 185 190 Ser Ile Asn Ile Ile Ser Met Val Ile Ala Asn Val Ile Phe Leu Val 195 200 205

Page 4014

069269_0225_SL.TXT

Val Pro Val Leu Phe Ile Phe Val Ser Tyr Ile Phe Ile Leu Ser Thr 210 215 220 Ile Leu Lys Ile Pro Ser Ala Glu Gly Lys Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ala His Leu Thr Val Val Ile Ile Phe Tyr Gly Thr Ile Leu 245 250 255 Phe Met Tyr Ala Lys Pro Lys Ala Lys Asp Phe Ser Gly Thr Asp Lys 260 265 270 Val Gln Val Thr Asp Lys Ile Ile Ser Leu Phe Tyr Gly Val Val Thr 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 290 295 300 Glu Ala Val Lys Asn Met Leu Cys Gln Lys Cys Ser Ser Glu Xaa 305 310 315

<210> 3585 <211> 888 <212> DNA <213> Felis catus <400> 3585 atgggaaatt actcagctgt gactgaattc tttctggcgg gactttccca ataccaagag 60 gtccagcttt ctttgtacat gttctgcctc atgatacctg ataatccccc tggaaaacag 120 tctcctgatt atcatcaaca ccctagattc ttgcctccac acccccatgt acttcttcct 180 tgggaacctc tcattcttgg acatttgtca tacatcatca tccattcctc tgatgctgac 240 attaaggtct gagagaaaaa tccatctcct ttattgactg tgctctgcag atggttgtct 300 tccttgggtg ggctgcactg agtgtatcct cctggctgtg atggcctatg attggtatgt 360 ggccatcggc aacccactaa ggtaccccac catcatgaat agagggcttt atgtgcacat 420 ggctgcttgg tcttggatca cagtgcaaac agtcctgaca atggtgctgc ctttctgtgg 480 gaataatgtc atcaaccatc ttacctgtga gttattggcc cttcttaaac tcatatgttc 540

Page 4015

069269_0225_SL.TXT

agatgtctcc atcaatgtgc ttatcataac agtggcaagt attgttttct tagtgacttc 600 cctaatgtta atttttattt cttatgtttt tatactctct ttcatcctga gacttaactc 660 tactgaaggg agaaagaaag ccttttcaac ctgttcagcc caccttgctg tagtagtttt 720 actctatgat tcagtcctct ttatgtacat gaagcccaag tcaaaggacg tgaagtttga 780 tgaaatcact gggtgttgaa ctccatcatc tacagcctga ggaataagaa ggtgaaagag 840 gctatgaaga aagtcttcag tagacactta cactcatgga aaatatga 888

<210> 3586 <211> 83 <212> PRT <213> Felis catus

<400> 3586 Met Gly Asn Tyr 1 Ser 5 Ala Val Thr Glu Phe Phe Leu Ala Gly Leu Ser 10 15 Gln Tyr Gln Glu Val Gln Leu Ser Leu Tyr Met Phe Cys Leu Met Ile 20 25 30 Pro Asp Asn Pro Pro Gly Lys Gln Ser Pro Asp Tyr His Gln His Pro 35 40 45 Arg Phe Leu Pro Pro His Pro His Val Leu Leu Pro Trp Glu Pro Leu 50 55 60 Ile Leu Gly His Leu Ser Tyr Ile Ile Ile His Ser Ser Asp Ala Asp 65 70 75 80

Ile Lys Val <210> 3587 <211> 964 <212> DNA <213> Felis catus <400> 3587 atggacacat gaggatgggg aattattcaa ccatgaccaa attctttatg gtgggacttt 60

Page 4016

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ccaaatacct agagctccag ctttttctgt tcgtgctctg cctcatcatg catgtgataa 120 ttctgctggg aaatagcctc ctcattgtca tcagcacatt tgattctcgc ctccacaccc 180 ccatgtactt cttccttggg aacctctcat tcttggacat ctgctacaca tcatcatcca 240 ttcccccgat gcttgtcata tttaagtctg agagaaaatc tatctccttc attggctgtg 300 ctctgcagat ggttgtctcc cttgggttgg gctctactga gtgtatcctc ctggctgtga 360 tggcctatga taggtatgtg gccatctgca acccactgag gtaccccatc atcatgaaca 420 ggatgcttta tgtgcacatg gctgcttggt cctggatcat aggctgccta aactccttag 480 tgcaaacagt cctgacaatg gtatttgcct ttctgtggga ataatgtcat tgatcatatt 540 acctgtgaga tcctggctct tcttaaactc atatgttcag atatctccat caatgtgctt 600 atcatgacag tggcaaatgt tttactggtg attcccctac tattaatttt catttcctat 660 gtttttatcc tctcttccat cctgagaatt aattctgcta agggagaatt aattctgcta 720 agggagaatt aattctacct gttctgccca cctgactgtg gttatcttct tccatggttc 780 agcccttttt atgtacatga agcccaagtc aaaggacaca aacaaatctg atgagatcat 840 tggactgtct tatggagtgg taaccccgat gttgaatccc atcatctaca gcatgaagga 900 taaagaagtg aaagaagcca tgaagaaagt cctaagcaga cacctgaatt tactgaaatc 960

atga 964 <210> 3588 <211> 173 <212> PRT <213> Felis catus

<400> 3588 Gly 1 His Met Arg Met Gly Asn Tyr Ser Thr Met Thr Lys Phe Phe Met 5 10 15 Val Gly Leu Ser Lys Tyr Leu Glu Leu Gln Leu Phe Leu Phe Val Leu 20 25 30 Cys Leu Ile Met His Val Ile Ile Leu Leu Gly Asn Ser Leu Leu Ile 35 40 45 Val Ile Ser Thr Phe Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Page 4017

069269_0225_SL.TXT

50 55 60

Leu Gly Asn Leu Ser Phe Leu Asp Ile Cys Tyr Thr Ser Ser Ser Ile 65 70 75 80 Pro Pro Met Leu Val Ile Phe Lys Ser Glu Arg Lys Ser Ile Ser Phe 85 90 95 Ile Gly Cys Ala Leu Gln Met Val Val Ser Leu Gly Leu Gly Ser Thr 100 105 110 Glu Cys Ile Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Pro Ile Ile Met Asn Arg Met Leu Tyr Val 130 135 140 His Met Ala Ala Trp Ser Trp Ile Ile Gly Cys Leu Asn Ser Leu Val 145 150 155 160 Gln Thr Val Leu Thr Met Val Phe Ala Phe Leu Trp Glu

165 170

<210> 3589 <211> 906 <212> DNA <213> Felis catus <400> 3589 ttttttcatg gcatctttga cttctttgtt tcttaaactg taaattatgg ggttcaacat 60 aggggtgagc actccataaa gcagtgaaat gattttatct acttcttggg agcttgagga 120 agaaggcttt aggtacatgg agagggcagc cccatagtac aagatcacca ccgtcaagtg 180 ggcaccacag gtagaaaaag ctttgtttct tccttctgct gagctgattc tcaggatagt 240 ggaaaggatg aagaaataag agatacaaat taagagcatt gggatgggca ggaggagcac 300 gctgaccacc agcatgatca cgtccatgag caaggaacgt gcacaagcta acttcagcac 360 ggccagaatt tcacacgtga agtggtctat gagattccca cagaggggta tctgcagggc 420 gcaagtggtt tccagcaggg cagtcagaca acccgtcacc caggagacag tggccatctg 480

Page 4018

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cacacagacc tgcctgttca tgatgacggg gtatctcagt gagttgcaaa tggccacgta 540 gcggtcatac gccatcacag ccagaagcac acactctgtg gagcccatgg caagggacag 600 atacatctgt acagcacacc cagaaaagac aatggttttc tgggatgaca gcaagttcac 660 cagcaacgtg ggaatagaag cagacgtgta acaaatatcc atgaaagaga gatttccgag 720 gaataagtac atgggggttt gaaggcgtga gtctaggaca gtgactaaaa taagagtgct 780 gttgcccaag agggttatca gatacatcac aagactgaag gcgaagagaa caatctctaa 840 ctttgggtat ctagaaaaac cctccaggaa aaaaaagctc caaatggtga ggttttctcc 900

ttgcat 906 <210> 3590 <211> 302 <212> PRT <213> Felis catus

<400> 3590 Leu Thr Ile Trp Ser Phe Phe Phe Leu Glu Gly Met Gln 1 Gly Glu Asn 5 10 15 Phe Ser Arg Tyr Pro Lys Leu Glu Ile Val Leu Phe Ala Phe Ser Leu 20 25 30 Val Met Tyr Leu Ile Thr Leu Leu Gly Asn Ser Thr Leu Ile Leu Val 35 40 45 Thr Val Leu Asp Ser Arg Leu Gln Thr Pro Met Tyr Leu Phe Leu Gly 50 55 60 Asn Leu Ser Phe Met Asp Ile Cys Tyr Thr Ser Ala Ser Ile Pro Thr 65 70 75 80 Leu Leu Val Asn Leu Leu Ser Ser Gln Lys Thr Ile Val Phe Ser Gly 85 90 95 Cys Ala Val Gln Met Tyr Leu Ser Leu Ala Met Gly Ser Thr Glu Cys 100 105 110

Page 4019

Val Leu Leu 115 Ala Val Met Ala 069269_0225_SL.TXT Tyr Asp Arg Tyr Val Ala 120 125 Ile Cys Asn Ser Leu Arg Tyr Pro Val Ile Met Asn Arg Gln Val Cys Val Gln Met 130 135 140 Ala Thr Val Ser Trp Val Thr Gly Cys Leu Thr Ala Leu Leu Glu Thr 145 150 155 160 Thr Cys Ala Leu Gln Ile Pro Leu Cys Gly Asn Leu Ile Asp His Phe 165 170 175 Thr Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Arg Ser Leu 180 185 190 Leu Met Asp Val Ile Met Leu Val Val Ser Val Leu Leu Leu Pro Ile 195 200 205 Pro Met Leu Leu Ile Cys Ile Ser Tyr Phe Phe Ile Leu Ser Thr Ile 210 215 220 Leu Arg Ile Ser Ser Ala Glu Gly Arg Asn Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Ala His Leu Thr Val Val Ile Leu Tyr Tyr Gly Ala Ala Leu Ser 245 250 255 Met Tyr Leu Lys Pro Ser Ser Ser Ser Ser Gln Glu Val Asp Lys Ile 260 265 270 Ile Ser Leu Leu Tyr Gly Val Leu Thr Pro Met Leu Asn Pro Ile Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Asp Ala Met Lys Lys 290 295 300

<210> 3591 <211> 838 <212> DNA <213> Felis catus

Page 4020

069269_0225_SL.TXT <400> 3591 gaactgtgta gacaagtgtt gctatgtggt ccctggcagt gtaggtggac aggggctgta aatagacata gaagatgctt ccataaaaga gggttaccac agtgaggtga gagccacagg tggagaaggc tttgcatttc ccagcagctg aggggatctt gagaactgtg atgaggattc gtatataaga gaaggtgatg cacagaaagg gggtcaccaa aacaactgaa cattctgaca ttatcacaat ttcattgaga aatgtggagg agcaggacaa tttcatcagg ggactgaggt cacagaggaa gtgatggata acattgttgt cacagaaggt gagacgattc agtagcagtg tgtgtaggag tgagtggagg tgaggaagtg agcagcaaaa ggccaccagc aggacacagc ggtggtggtt catggtggtg acatagtgga aggggtcaca gatggccaca tagcggtcaa aggccatgac cgccagaagg aagctgtcag tgttgcccag agcataaata aaatacatct gtgtcagaca cccagcatag gagatggtct tctctgacag gaagttcact agcatcctgg ggacaatggt tgttgtaaag caaatgtcag tgaaggacag gaaactcagg aagaaataca tgggggtctg gagctggggg tcagagtgga tggcgaggat gatgagcagg ttccctgtta tggtgaccag gtacatggtg aggaagagga taaagagtgg tttctggtcc tcaggccggg aggagagtcc caggaggata aactcggaaa cactgctggt ttggttgact ctttccat <210> 3592 <211> 280 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (280)..(280) <223> Any amino acid

120

180

240

300

360

420

480

540

600

660

720

780

838

<400> 3592 Met Glu Arg Val Asn Gln Thr Ser Ser Val Ser Glu Phe Ile Leu Leu 1 5 10 15 Gly Leu Ser Ser Arg Pro Glu Asp Gln Lys Pro Leu Phe Ile Leu Phe 20 25 30 Leu Thr Met Tyr Leu Val Thr Ile Thr Gly Asn Leu Leu Ile Ile Leu Page 402 1

069269_0225_SL.TXT 40 45

Ala Ile His Ser Asp Pro Gln Leu Gln Thr Pro Met Tyr Phe Phe Leu 50 55 60 Ser Phe Leu Ser Phe Thr Asp Ile Cys Phe Thr Thr Thr Ile Val Pro 65 70 75 80 Arg Met Leu Val Asn Phe Leu Ser Glu Lys Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Met Tyr Phe Ile Tyr Ala Leu Gly Asn Thr Asp Ser 100 105 110 Phe Leu Leu Ala Val Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Asp 115 120 125 Pro Phe His Tyr Val Thr Thr Met Asn His His Arg Cys Val Leu Leu 130 135 140 Val Ala Phe Cys Cys Ser Leu Pro His Leu His Ser Leu Leu His Thr 145 150 155 160 Leu Leu Leu Asn Arg Leu Thr Phe Cys Asp Asn Asn Val Ile His His 165 170 175 Phe Leu Cys Asp Leu Ser Pro Leu Met Lys Leu Ser Cys Ser Ser Thr 180 185 190 Phe Leu Asn Glu Ile Val Ile Met Ser Glu Cys Ser Val Val Leu Val 195 200 205 Thr Pro Phe Leu Cys Ile Thr Phe Ser Tyr Ile Arg Ile Leu Ile Thr 210 215 220 Val Leu Lys Ile Pro Ser Ala Ala Gly Lys Cys Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Thr Leu Phe Tyr Gly Ser Ile Phe

Page 4022

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245 250 255

Tyr Val Tyr Leu Gln Pro Leu Ser Thr Tyr Thr Ala Arg Asp His Ile 260 265 270

Ala Thr Leu Val Tyr Thr Val Xaa 275 280 <210> 3593 <211> 880 <212> DNA <213> Felis catus <400> 3593 atgaggaggg agaaccagag cagcgtgtcc gagttcctcc tcctggggct ccccatccag 60 ccagagcagc agggcatatt cttcaccctg ttcctgggca tgtacctgac tacagtgctg 120 gggaacctgc tcatcatcct gctcgtcagg ctggactctc gctttcacac gcctatgtac 180 ttcttcctta gccacttggc cttcactgat gtttcctttt catctgtcac agttccaaag 240 atgctcatga acatgcagac tcagcaacaa tccattccct atgtggggtg catttcacag 300 gtgtatttct taatattttt tggttgtctt gacaatttcc ttcttgcagt gatggcatat 360 gacaggtatg tggccatctg tcagccactc cactactcta ctgtcatgag gcaggagcta 420 tgtatctcat tagtggctgg atcttcgttc ttctgttaca ttcatgccct gttgcacacc 480 cttctcttgg tccaactgtc cttctgtgat aataccatcc ctcacttctt ttgtgacctc 540 actgtgctcc tgaggataag ctgctcagac atctctctca atgagctgat catctttact 600 gaaggaggaa ttcttttcat cctgcctttg agtagtatct tgggctcata tattcgtata 660 gggacaactg tcctaagggt cccctccact aaaggactct ttaaagcctt ttctacctgt 720 ggctcccatc tttttgtggt gtctgtatac tatgggacac ttgcaggtgt ttactttttc 780 tccttatcat ggaactttaa tgacaaagac ataattgctt cagtcatgta cacagtaatt 840 acccctatgc tgaacccctt tatctatagc ctgaggaaca 880 <210> 3594 <211> 294 <212> PRT <213> Felis catus

Page 4023

069269_0225_SL.TXT <220>

<221> MOD_RES <222> (294)..(294) <223> Any amino acid

<400> 3594 Met 1 Arg Arg Glu Asn 5 Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly 10 15 Leu Pro Ile Gln Pro Glu Gln Gln Gly Ile Phe Phe Thr Leu Phe Leu 20 25 30 Gly Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Leu 35 40 45 Val Arg Leu Asp Ser Arg Phe His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ala Phe Thr Asp Val Ser Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Met Asn Met Gln Thr Gln Gln Gln Ser Ile Pro Tyr Val Gly 85 90 95 Cys Ile Ser Gln Val Tyr Phe Leu Ile Phe Phe Gly Cys Leu Asp Asn 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Gln 115 120 125 Pro Leu His Tyr Ser Thr Val Met Arg Gln Glu Leu Cys Ile Ser Leu 130 135 140 Val Ala Gly Ser Ser Phe Phe Cys Tyr Ile His Ala Leu Leu His Thr 145 150 155 160 Leu Leu Leu Val Gln Leu Ser Phe Cys Asp Asn Thr Ile Pro His Phe 165 170 175

Page 4024

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Phe Cys Asp Leu Thr Val Leu Leu Arg Ile Ser Cys Ser Asp Ile Ser 180 185 190 Leu Asn Glu Leu Ile Ile Phe Thr Glu Gly Gly Ile Leu Phe Ile Leu 195 200 205 Pro Leu Ser Ser Ile Leu Gly Ser Tyr Ile Arg Ile Gly Thr Thr Val 210 215 220 Leu Arg Val Pro Ser Thr Lys Gly Leu Phe Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Ser His Leu Phe Val Val Ser Val Tyr Tyr Gly Thr Leu Ala Gly 245 250 255 Val Tyr Phe Phe Ser Leu Ser Trp Asn Phe Asn Asp Lys Asp Ile Ile 260 265 270 Ala Ser Val Met Tyr Thr Val Ile Thr Pro Met Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Xaa

290 <210> 3595 <211> 893 <212> DNA <213> Felis catus <400> 3595

atgagggggg agaaccagag cagcgtgtcc gagttcctcc tcctggggct ccccatctgg 60 ccagagcagc aggccctgtt cttcgccctg ttcctgggca tgtacctgat cacggtgctg 120 gggaacctgc tcatcatcct gctcatcagg ctggactccc gcctccacac ccccatgtac 180 ttcttcctca gccacttggc cttcactgat gtctctttct cttctgtcac tgtcccaaag 240 atgctgatga acatgcagac tcagcaccta tcaatctcct atccaggatg tatttcacag 300 atgtattttt atatactttt cggttgtgtt gataacctcc ttcttgcagt gatggcatat 360 gacaggtatg tagccatctg tcatcctcta tactacacca ccatcatgaa ggaggatctg 420

Page 4025

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tgtgtgctgc tggtggctgg ctcctggatt ctctcctgtg gcagtgccct cttacacacc 480 ctcctcctga cccaggtgtc cttctgtgct gacaacatca tcccccactt tttctgtagc 540 ctccccatcc tactcaggct gtcctgttca aacacctctg ttaatgagct ggtcatattt 600 actgcagggg ctgcagttgt cattttcccg ttgactggca tcctggtctc ttatggacgc 660 attggggctt ctattctgaa ggtgccctct accaaaggta tctgcaaagc cttgtccacc 720 tgtggctccc acctctctgt agtgtctcta ttctatggaa caattatggc actgtacttt 780 tcttcctcat caagcaactc caatgacaac gacatgattg cctcactgat gtatacagtg 840 gtcaccccca tgttgaaccc cttcatctat agcctaagga acagagacat gaa 893

<210> 3596 <211> 298 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (298)..(298) <223> Any amino acid <400> 3596

Met Arg Gly Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Pro Ile Trp Pro Glu Gln Gln Ala Leu Phe Phe Ala Leu Phe Leu 20 25 30 Gly Met Tyr Leu Ile Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ala Phe Thr Asp Val Ser Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Met Asn Met Gln Thr Gln His Leu Ser Ile Ser Tyr Pro Gly 85 90 95

Page 4026

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Cys Ile Ser Gln Met Tyr Phe Tyr Ile Leu Phe Gly Cys Val Asp Asn 100 105 110 Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Tyr Tyr Thr Thr Ile Met Lys Glu Asp Leu Cys Val Leu Leu 130 135 140 Val Ala Gly Ser Trp Ile Leu Ser Cys Gly Ser Ala Leu Leu His Thr 145 150 155 160 Leu Leu Leu Thr Gln Val Ser Phe Cys Ala Asp Asn Ile Ile Pro His 165 170 175 Phe Phe Cys Ser Leu Pro Ile Leu Leu Arg Leu Ser Cys Ser Asn Thr 180 185 190 Ser Val Asn Glu Leu Val Ile Phe Thr Ala Gly Ala Ala Val Val Ile 195 200 205 Phe Pro Leu Thr Gly Ile Leu Val Ser Tyr Gly Arg Ile Gly Ala Ser 210 215 220 Ile Leu Lys Val Pro Ser Thr Lys Gly Ile Cys Lys Ala Leu Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Ile Met 245 250 255 Ala Leu Tyr Phe Ser Ser Ser Ser Ser Asn Ser Asn Asp Asn Asp Met 260 265 270 Ile Ala Ser Leu Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Xaa

290 295

Page 4027

069269_0225_SL.TXT <210> 3597 <211> 879 <212> DNA <213> Felis catus <400> 3597 catgtctgag ttccttctcc tggggctccc catccagcca gagcagcagg ccatgttctt 60 caccctgttc ctgggcatgt acctgatcat gtgctgggga acctgctcat catcctgctc 120 atcagggtgg actctcgcct ccacaccccc atgtacttct tcctcagcca cttggccttc 180 actgatgtct ccttctcatc tgtcaccatc cccaagatgc tgataaacat gcatacttgg 240 gatcagtcca tcccctatgc aagctgtgta acacagatat attttttcca tatttttttg 300 gctgtatcaa taaacttctt cttgcagtga tggcatatga gaggtacatg gccatttgcc 360 accctttaca ctacaccacc atcatgaggg agaagctgtg tatatttgtt ctggctggat 420 cctggttccc tctcctgtac aagtgccctg tcccacacca tcttcctggc tcaactgtcc 480 ttttgtgctg acaacaccat ctcccacttc ttctgtgacc ttgctgacct gcttaaactc 540 tccagctcag acacttacct caatgaagtt tttatcttca ctgttgggga attggtcatt 600 accctgtcgt ttattggtgc tctagtctct tatggtcgca ttggggccac catcctgaga 660 tttccctcga tcaaggggat atataaagct ttggccacct atggctccca cctctctgtg 720 gtatttctgt tctgtgggac aatcacggta ctgcactttt tcccatcatc aagcaactcc 780 aatgacaaag acataattgc ttcagtgatg tacatagtgg tcacccccat gctgaacccc 840 ttcatctata gcctgaggaa cagagatata aaaggagcc 879 <210> 3598 <211> 73 <212> PRT <213> Felis catus

<400> 3598 Met Ser Glu Phe Leu Leu Leu Gly Leu Pro Ile Gln Pro Glu Gln Gln 1 5 10 15

Ala Met Phe Phe Thr Leu Phe Leu Gly Met Tyr Leu Ile Met Cys Trp 20 25 30

Page 4028

0 69269_02 25_S iL.TX T Gly Thr Cys Ser Ser Ser Cys Ser Ser Gly Trp Thr Leu Ala Ser Thr 35 40 45 Pro Pro Cys Thr Ser Ser Ser Ala Thr Trp Pro Ser Leu Met Ser Pro 50 55 60

Ser His Leu Ser Pro Ser Pro Arg Cys 65 70

<210> 3599 <211> 905 <212> DNA <213> Felis catus <400> 3599

ctcagggccc ctttcatgtc tttatttctc aggctgtaaa tgaaagggtt caacatgggg 60 gtgaccactg tgtacatcaa ggaagcaatt aggtttttgt tattggtgtt gttggatgag 120 ggaagaaaat ataggccaat aattgcccca taatagagag tcactactga gagatgtgat 180 ccacaagtgg acaaggcttt gcagatgccc ttggtagaag gaacccggag gatggtggcc 240 ccaatatggc cgtaagaaac cacaatgcat aagaatggaa gcataatggc tgttaatcct 300 gcagtaaaga tcaccaattg gttgagggaa gtgtctgagc aagacaattt gagcaaggca 360 gcaaggtcac agaagaagtg ggggacggtg tggtcagcac agaaggacag ctgggctagg 420 agaagggtat gcaaaagagc acaagcacaa gcaatgaccc aggatccagc cactagcatg 480 acacagatgc tctgactcat gacgatggta taatgcagag ggtgacagat ggccacatac 540 ctgtcatagg ccattgaagt gatcaagaaa ctgtctaaat cagcgcaaaa tatgaagaaa 600 tatgtctgtg aaatgcatcc ttcataggag atggatttgt acttagcatg catgttcatc 660 agcatctttg ggacagtgac agatgaaaag gaaacatcag tgaaggccaa gtggctgagg 720 aagaagtaca tgggggtgtg gaggcgagag tccagtctga tgagcaggat gatgagcagg 780 ttccccagca ccgtggtcag gtacatgccc aggaacaggg caaagaacat ggcctgttgc 840 tctggccgga tggggagccc caggaggaga aactcggaca cgctgctctg gttctccctc 900

ctcat 905 <210> 3600

Page 4029

069269_0225_SL.TXT <211> 302 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (302)..(302) <223> Any amino acid

<400> 3600 Met Arg 1 Arg Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly 15 5 10 Leu Pro Ile Arg Pro Glu Gln Gln Ala Met Phe Phe Ala Leu Phe Leu 20 25 30 Gly Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ala Phe Thr Asp Val Ser Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Met Asn Met His Ala Lys Tyr Lys Ser Ile Ser Tyr Glu Gly 85 90 95 Cys Ile Ser Gln Thr Tyr Phe Phe Ile Phe Cys Ala Asp Leu Asp Ser 100 105 110 Phe Leu Ile Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Ile Val Met Ser Gln Ser Ile Cys Val Met Leu 130 135 140 Val Ala Gly Ser Trp Val Ile Ala Cys Ala Cys Ala Leu Leu His Thr 145 150 155 160 Leu Leu Leu Ala Gln Leu Ser Phe Cys Ala Asp His Thr Val Pro His

Page 4030

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165 170 175

Phe Phe Cys Asp Leu Ala Ala Leu 180 Leu Lys 185 Leu Ser Cys Ser 190 Asp Thr Ser Leu Asn Gln Leu Val Ile Phe Thr Ala Gly Leu Thr Ala Ile Met 195 200 205 Leu Pro Phe Leu Cys Ile Val Val Ser Tyr Gly His Ile Gly Ala Thr 210 215 220 Ile Leu Arg Val Pro Ser Thr Lys Gly Ile Cys Lys Ala Leu Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Thr Leu Tyr Tyr Gly Ala Ile Ile 245 250 255 Gly Leu Tyr Phe Leu Pro Ser Ser Asn Asn Thr Asn Asn Lys Asn Leu 260 265 270 Ile Ala Ser Leu Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Gly Ala Leu Xaa 290 295 300

<210> 3601 <211> 923 <212> DNA <213> Felis catus <400> 3601

atgaggaggg agaaccagag cagcgtgtcc gagtttctcc tcctggggct ccccatccgg 60 ccagagcagc aggccatgtt cttcgccctg ttcctgggca tgtacctgac cacagtgctg 120 gggaacctgc tcatcatcct gctcatcagg ctggactctc gcctccacac ccctatgtac 180 ttcttcctca gccacttggc cttcactgat gtctccttct catctgtcac tgtcccaaaa 240 atgttgatgg acatgcatgc taagtacaaa tccatcccct atgaagggtg tatttcacaa 300 atgtattttt ttatattttt tactgacctg gacagcttcc ttattacatc aatggcatat 360

Page 4031

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gatcgctatg cggctatatg tcaccctctt cattatacca ccatcatgag ggaagagctg 420 tgtgccttac tagttgctat atcttggatc ctgtcctgtg ccagctctct ttcccacacc 480 cttctcctca cccagttatc cttctgtgct gacaatgcca tcccccattt cttctgtgac 540 cttggtgctc tgcttaagat atcctgttca ggcatcttcc tcaatgagtt ggtcatgttc 600 acagtagggg tggtggtcat taccctgcca ttcatatgta ttctggtatc ttacggttac 660 attggggcca ccatcatgaa aggtccttcc accaagggga tctgcaaagc actgtccaca 720 tgtggctccc acctttctat agtgtctctg tattatgggg caatatttgg gcagtatctt 780 ttccccaaat taagcaattt cattgacaag gacatcattg tggctctcat gtacacagtg 840 gtcacaccca tgttgaaccc ctttatctac agcctcagga acagggacat gaaagaagcc 900 ctggggaaac tcttcggtag ggc 923

<210> 3602 <211> 308 <212> PRT <213> Felis catus <400> 3602

Met Arg Arg Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Pro Ile Arg Pro Glu Gln Gln Ala Met Phe Phe Ala Leu Phe Leu 20 25 30 Gly Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Leu 35 40 45 Ile Arg Leu Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ala Phe Thr Asp Val Ser Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Met Asp Met His Ala Lys Tyr Lys Ser Ile Pro Tyr Glu Gly 85 90 95

Page 4032

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Cys Ile Ser Gln 100 Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Ser 105 110 Phe Leu Ile Thr Ser Met Ala Tyr Asp Arg Tyr Ala Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Thr Ile Met Arg Glu Glu Leu Cys Ala Leu Leu 130 135 140 Val Ala Ile Ser Trp Ile Leu Ser Cys Ala Ser Ser Leu Ser His Thr 145 150 155 160 Leu Leu Leu Thr Gln Leu Ser Phe Cys Ala Asp Asn Ala Ile Pro His 165 170 175 Phe Phe Cys Asp Leu Gly Ala Leu Leu Lys Ile Ser Cys Ser Gly Ile 180 185 190 Phe Leu Asn Glu Leu Val Met Phe Thr Val Gly Val Val Val Ile Thr 195 200 205 Leu Pro Phe Ile Cys Ile Leu Val Ser Tyr Gly Tyr Ile Gly Ala Thr 210 215 220 Ile Met Lys Gly Pro Ser Thr Lys Gly Ile Cys Lys Ala Leu Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Ile Val Ser Leu Tyr Tyr Gly Ala Ile Phe 245 250 255 Gly Gln Tyr Leu Phe Pro Lys Leu Ser Asn Phe Ile Asp Lys Asp Ile 260 265 270 Ile Val Ala Leu Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Glu Ala Leu Gly Lys Leu 290 295 300

Page 4033

069269_0225_SL.TXT

Phe Gly Arg Ala

305 <210> 3603 <211> 711 <212> DNA <213> Felis catus <400> 3603 atgaggaggg agaaccagag cagcgtgtcc gagttcctcc tcctggggct ccccatccgg 60 ccagagcagc agggcatgtt cttcacccta ttcctgggca tgtacctgac cacggtgctg 120 gggaacctgc tcatcatcct gctcatcagg ctggactctt gcctccacac ccctatgtac 180 ttcttcctca gccacttggc cctcacagat gtctccttct catctgtcac cgtccccaag 240 atgctgataa acatgcactt tcaggatcaa tccatcccct acacaggctg tgtaacacag 300 atgtattttt tcatattttt tactgatctg gacaattttc ttctcacatc gatggcatat 360 gatcggtatg tggctatctg tcacccactc cactatacca ccatcatgag agagggggtg 420 tgtatcttac tagtagctgt atcttggatc ctgtcctgtg ccagtgccct gtctcacact 480 ctcctcttgg cccagctgtc cttttgtgct gacaatgcca tcccccattt cttctgtgac 540 cttggtgtcc tgctcaagct ctcctgctca gacacctccc ttaatgagct ggtcattttc 600 acagcaggtg tggcagtcat tactatccca ctaatttgca tcttgatctc ttatggccac 660 attggggcca ccatcttgaa ggttccctct accaggggga tctgcaaagc c 711 <210> 3604 <211> 237 <212> PRT <213> Felis catus <400> 3604

Met Arg Arg Glu Asn Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Pro Ile Arg Pro Glu Gln Gln Gly Met Phe Phe Thr Leu Phe Leu 20 25 30 Gly Met Tyr Leu Thr Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Leu

35 40 45

Page 4034

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Ile Arg Leu Asp 50 Ser Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser 55 60 His Leu Ala Leu Thr Asp Val Ser Phe Ser Ser Val Thr Val Pro Lys 65 70 75 80 Met Leu Ile Asn Met His Phe Gln Asp Gln Ser Ile Pro Tyr Thr Gly 85 90 95 Cys Val Thr Gln Met Tyr Phe Phe Ile Phe Phe Thr Asp Leu Asp Asn 100 105 110 Phe Leu Leu Thr Ser Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Thr Ile Met Arg Glu Gly Val Cys Ile Leu Leu 130 135 140 Val Ala Val Ser Trp Ile Leu Ser Cys Ala Ser Ala Leu Ser His Thr 145 150 155 160 Leu Leu Leu Ala Gln Leu Ser Phe Cys Ala Asp Asn Ala Ile Pro His 165 170 175 Phe Phe Cys Asp Leu Gly Val Leu Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190 Ser Leu Asn Glu Leu Val Ile Phe Thr Ala Gly Val Ala Val Ile Thr 195 200 205 Ile Pro Leu Ile Cys Ile Leu Ile Ser Tyr Gly His Ile Gly Ala Thr 210 215 220 Ile Leu Lys Val Pro Ser Thr Arg Gly Ile Cys Lys Ala

225 230 235 <210> 3605 <211> 863 <212> DNA

Page 4035

069269_0225_SL.TXT <213> Felis catus <400> 3605

gagttccttc tcctggggct ccccatccgg ccagagcagc agggcatgtt cttcaccctg 60 ttcctgggca tgtacctgac cacagtgctg gggaacctgc tcatcatcct gctcatcagg 120 ctggactctc gccttcacac ccccatgtac ttcttcctca gccacttggc cttctctgac 180 atttcccttt catctgtcac agttccaaag atgctcatga acatgcagac tcagcaacaa 240 tccatcccct atatggggtg catttcacag gtgtatttct ttatattttt tggttgcctt 300 gacaactttc ttctcacagt gatggcatat gacaggtatg tggccatctg tcaccctctc 360 cactacacca ccaccatgag ggaggagcta tgtatcatcc tagtggctgg atcctggttc 420 ttctcttgca tccaagctct tttgcacacc ctcctcgtgg accagttgtc cttctgtgca 480 gggactgtca tcccacactt cttttgtgat cttgctgctg tgctcaagtc ttcctgctca 540 gacacctctt tcaatgagct gcttatcctc actgaaggag cattggtact cattctacca 600 ttgagtggta tcttgggctc atatatccat atggcaggca tcattctgaa ggtcccctcc 660 tttaaaagaa tctccaaagc cttgtctaca tgtggctccc atctctttgt ggtgtgttta 720 tactatggga caattgcagg tgtttacttt ttctcttcat caggcaactc ccaagacaag 780 gacataattg cttctgtaat gtacatggtg gtcaccccta tgctgaaccc ctgcatctac 840 agcctgagga ataaggacat gaa 863

<210> 3606 <211> 288 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (288)..(288) <223> Any amino acid <400> 3606

Glu Phe Leu Leu Leu Gly Leu Pro Ile Arg Pro Glu Gln Gln Gly Met 1 5 10 15

Phe Phe Thr Leu Phe Leu Gly Met Tyr Leu Thr Thr Val Leu Gly Asn 20 25 30

Page 4036

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Leu Leu Ile 35 Ile Leu Leu Ile Arg Leu Asp Ser Arg Leu His Thr Pro 40 45 Met Tyr Phe Phe Leu Ser His Leu Ala Phe Ser Asp Ile Ser Leu Ser 50 55 60 Ser Val Thr Val Pro Lys Met Leu Met Asn Met Gln Thr Gln Gln Gln 65 70 75 80 Ser Ile Pro Tyr Met Gly Cys Ile Ser Gln Val Tyr Phe Phe Ile Phe 85 90 95 Phe Gly Cys Leu Asp Asn Phe Leu Leu Thr Val Met Ala Tyr Asp Arg 100 105 110 Tyr Val Ala Ile Cys His Pro Leu His Tyr Thr Thr Thr Met Arg Glu 115 120 125 Glu Leu Cys Ile Ile Leu Val Ala Gly Ser Trp Phe Phe Ser Cys Ile 130 135 140 Gln Ala Leu Leu His Thr Leu Leu Val Asp Gln Leu Ser Phe Cys Ala 145 150 155 160 Gly Thr Val Ile Pro His Phe Phe Cys Asp Leu Ala Ala Val Leu Lys 165 170 175 Ser Ser Cys Ser Asp Thr Ser Phe Asn Glu Leu Leu Ile Leu Thr Glu 180 185 190 Gly Ala Leu Val Leu Ile Leu Pro Leu Ser Gly Ile Leu Gly Ser Tyr 195 200 205 Ile His Met Ala Gly Ile Ile Leu Lys Val Pro Ser Phe Lys Arg Ile 210 215 220 Ser Lys Ala Leu Ser Thr Cys Gly Ser His Leu Phe Val Val Cys Leu 225 230 235 240

Page 4037

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Tyr Tyr Gly Thr Ile Ala Gly Val Tyr Phe Phe Ser Ser Ser Gly Asn 245 250 255 Ser Gln Asp Lys Asp Ile Ile Ala Ser Val Met Tyr Met Val Val Thr 260 265 270 Pro Met Leu Asn Pro Cys Ile Tyr Ser Leu Arg Asn Lys Asp Met Xaa 275 280 285

<210> 3607 <211> 849 <212> DNA <213> Felis catus <400> 3607

ccacagcagc agcctctcct attcggactc ttcctgggca tgtacctggt caccatggtg 60 gggaatctgc tcatcatcct ggccattgcc tcagacctgc atctccacac ccccatgtac 120 ctctttctag ccaacctttc cttttctgac attggtttca tctctacagt aattcccaag 180 atgctagata atattggctc aggaagtaaa aggatttctt atggtgggtg tctgacacag 240 ctttatttct ttggcctatt tgcagatctg gacaactttc tcctggctgt gatggcactt 300 gaccgctatg tggccatcag ccaccccctc cattatgcca tgatcatgaa ctaccaacgc 360 tgtgtcctat tagtggctgg gtcatgggtg gtcactacct tccacgccct agtgcatacc 420 ttcctggtaa ctaggctttc tttctgtggc cccaatatca tcccccattt cttctgtgat 480 cttgtcccac tcctgaatct ggcctgctcc agtacttatg tcaatgacct ggtgctcatc 540 cttgtggcag gaacattgct aattggaccc ttcatctgca tccttacttc ttacttttat 600 attgcattgg ctatcctaag aatcaattcc ccaaagggta agcaaagggc cttctccaac 660 tgcacctccc acctctctgt ggtctctctg ttttatagca cagctattgg ggtctattta 720 tgtcctccat catccccctc aggtggaaag aatagagtct tctcaataat gtacacagtg 780 gtgaccccca tgctgaaccc cttcatctac agcctaagaa acagggatat gaagggggcg 840

ctaggaaaa 849 <210> 3608

Page 4038

069269_0225_SL.TXT <211> 283 <212> PRT <213> Felis catus

<400> 3608 Gly Met Tyr Leu 15 Pro 1 Gln Gln Gln Pro Leu Leu Phe 5 Gly Leu 10 Phe Leu Val Thr Met Val Gly Asn Leu Leu Ile Ile Leu Ala Ile Ala Ser Asp 20 25 30 Leu His Leu His Thr Pro Met Tyr Leu Phe Leu Ala Asn Leu Ser Phe 35 40 45 Ser Asp Ile Gly Phe Ile Ser Thr Val Ile Pro Lys Met Leu Asp Asn 50 55 60 Ile Gly Ser Gly Ser Lys Arg Ile Ser Tyr Gly Gly Cys Leu Thr Gln 65 70 75 80 Leu Tyr Phe Phe Gly Leu Phe Ala Asp Leu Asp Asn Phe Leu Leu Ala 85 90 95 Val Met Ala Leu Asp Arg Tyr Val Ala Ile Ser His Pro Leu His Tyr 100 105 110 Ala Met Ile Met Asn Tyr Gln Arg Cys Val Leu Leu Val Ala Gly Ser 115 120 125 Trp Val Val Thr Thr Phe His Ala Leu Val His Thr Phe Leu Val Thr 130 135 140 Arg Leu Ser Phe Cys Gly Pro Asn Ile Ile Pro His Phe Phe Cys Asp 145 150 155 160 Leu Val Pro Leu Leu Asn Leu Ala Cys Ser Ser Thr Tyr Val Asn Asp 165 170 175 Leu Val Leu Ile Leu Val Ala Gly Thr Leu Leu Ile Gly Pro Phe Ile 180 185 190

Page 4039

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Cys Ile Leu Thr 195 Ser Tyr Phe Tyr Ile Ala Leu Ala Ile Leu Arg Ile 200 205 Asn Ser Pro Lys Gly Lys Gln Arg Ala Phe Ser Asn Cys Thr Ser His 210 215 220 Leu Ser Val Val Ser Leu Phe Tyr Ser Thr Ala Ile Gly Val Tyr Leu 225 230 235 240 Cys Pro Pro Ser Ser Pro Ser Gly Gly Lys Asn Arg Val Phe Ser Ile 245 250 255 Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu 260 265 270 Arg Asn Arg Asp Met Lys Gly Ala Leu Gly Lys

275 280 <210> 3609 <211> 929 <212> DNA <213> Felis catus <400> 3609

atggttaata acagctggac cagtgtatcc cattttgttc tcttgggcat atctacccac 60 ctggaagagc agatcccact ctttcttctt tttctactga tgtatgcgat caacattttt 120 gggaactttg ccatcatcac actgattatc tctactccac gtctccacac ccccatgtac 180 atcttcctca gtaatttggc tttggcagac atctgtttca cctccaccac ggtccccaag 240 atgctacaga acattttctc gcctacaaag gccatttcct acatgggctg cttagcccag 300 acctatttct tcatttgctt tgcagccatg gaaaacttcc ttctggctgt gatggcctat 360 gatagataca tcgctatctg ctaccctttc cgctacccta tgatcctgac cagaatgctg 420 tgttcacaga tggtggctct gtgccatatc ctctcccatc ttcatgccct gctgcacacc 480 tttcttatgg gccgattaat cttctgtgca gataacaaga tcccccattt cttctgtgac 540 ctctaccctc tgatgaagat ttcctgctcc agcccctacc tcaacaccct gatgattcac 600 acggagggtg ttattgtcat caatggagct ctggctttca tcattgcctc ctatgcccgc 660

Page 4040

069269_0225_SL.TXT atcatctcag tggtcctcca gatcccctcg gccaagagca aatggagagc tttttctacc tgtggctccc acctcactgt ggtgtctatc ttctatggca cactcacatg ggtctacttc cggcccctta ccagctattc agtgactgag ggtcgcattc tgacagtcat gtacacagtg gtgaccccca tgctgaaccc cttcatttac agcctgagga atggggatgt caagggagcc ttcagaaaat gggtgagcag aatgtggac

720

780

840

900

929 <210> 3610 <211> 310 <212> PRT <213> Felis catus

<400> 3610 Asn Ser 5 Trp Thr Ser Val Ser His Phe Val Leu Leu Gly Met 1 Val Asn 10 15 Ile Ser Thr His Leu Glu Glu Gln Ile Pro Leu Phe Leu Leu Phe Leu 20 25 30 Leu Met Tyr Ala Ile Asn Ile Phe Gly Asn Phe Ala Ile Ile Thr Leu 35 40 45 Ile Ile Ser Thr Pro Arg Leu His Thr Pro Met Tyr Ile Phe Leu Ser 50 55 60 Asn Leu Ala Leu Ala Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Gln Asn Ile Phe Ser Pro Thr Lys Ala Ile Ser Tyr Met Gly 85 90 95 Cys Leu Ala Gln Thr Tyr Phe Phe Ile Cys Phe Ala Ala Met Glu Asn 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Cys Tyr 115 120 125 Pro Phe Arg Tyr Pro Met Ile Leu Thr Arg Met Leu Cys Ser Gln Met 130 135 140

Page 4041

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Val 145 Ala Leu Cys His Ile 150 Leu Ser His Leu His Ala Leu Leu His Thr 155 160 Phe Leu Met Gly Arg Leu Ile Phe Cys Ala Asp Asn Lys Ile Pro His 165 170 175 Phe Phe Cys Asp Leu Tyr Pro Leu Met Lys Ile Ser Cys Ser Ser Pro 180 185 190 Tyr Leu Asn Thr Leu Met Ile His Thr Glu Gly Val Ile Val Ile Asn 195 200 205 Gly Ala Leu Ala Phe Ile Ile Ala Ser Tyr Ala Arg Ile Ile Ser Val 210 215 220 Val Leu Gln Ile Pro Ser Ala Lys Ser Lys Trp Arg Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Thr Val Val Ser Ile Phe Tyr Gly Thr Leu Thr 245 250 255 Trp Val Tyr Phe Arg Pro Leu Thr Ser Tyr Ser Val Thr Glu Gly Arg 260 265 270 Ile Leu Thr Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Gly Asp Val Lys Gly Ala Phe Arg Lys Trp 290 295 300 Val Ser Arg Met Trp Thr

305 310 <210> 3611 <211> 933 <212> DNA <213> Felis catus <400> 3611

Page 4042

069269_0225_SL.TXT

atggagacca agaactacag cagtgactca ggctttatcc tcctgggcct ctcttccaac 60 cctcagctac agaaacctct ctttgccatc ttcctcatca tgtacttggt caccgtgctg 120 ggcaatgtac tcatcatcct ggccatccac tcagaccccc gactccatac ccccatgtac 180 tttttcgtca gcaacctgtc cttcatagat atctgcttca caactgtcat tgtgcccaag 240 atgctggtga atttactgtc agagacaaag gcgatctcct tcctgggatg cctggtccag 300 atgtacttct tcatggcctg tgggaacact gacagttacc tgctggcctc catggccata 360 gaccggctgg tagccatctg ccaccccttc cattacaata gggttatgaa tccacggcgc 420 tgcctcctca tgctgctggg ttcttgcacc atctcccacc tgcactccct gctccgtgtg 480 ctactcatgt cccgcctgtc cttctgtgcc tcccatgtca ttaagcactt tttttgtgac 540 acccagcctg tgctaaagct atcctgctct gacacgtcct ctagccagat tgtggtcatg 600 accgagaccc tggctgtcat cgcgaccccc tttctgtgca ttctcttctc ctacctgcga 660 atcatcgtca ctgtgctcag aattccctct gcagccggca agtggaaggc cttctctacc 720 tgtagctccc accttaccgt agtggccttg acctatggga gtgtcatcta tgtgtatttc 780 aggcccctgt cgatgtactc agtggtgaag gaccgggtag ccacagtcat gtacacagta 840 gtgacaccca tgctgaaccc cttcatctat agtctgagga acaaagacat gaacaggggc 900 ttaaagaaat taaggaacag aattcactta tag 933

<210> 3612 <211> 310 <212> PRT <213> Felis catus

<400> 3612 Met 1 Glu Thr Lys Asn Tyr Ser Ser Asp Ser Gly Phe Ile Leu Leu Gly 5 10 15 Leu Ser Ser Asn Pro Gln Leu Gln Lys Pro Leu Phe Ala Ile Phe Leu 20 25 30 Ile Met Tyr Leu Val Thr Val Leu Gly Asn Val Leu Ile Ile Leu Ala 35 40 45 Ile His Ser Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Val Ser Page 4043

069269_0225_SL.TXT

50 55 60 Asn Leu Ser Phe Ile Asp Ile Cys Phe Thr Thr Val Ile Val Pro Lys 65 70 75 80 Met Leu Val Asn Leu Leu Ser Glu Thr Lys Ala Ile Ser Phe Leu Gly 85 90 95 Cys Leu Val Gln Met Tyr Phe Phe Met Ala Cys Gly Asn Thr Asp Ser 100 105 110 Tyr Leu Leu Ala Ser Met Ala Ile Asp Arg Leu Val Ala Ile Cys His 115 120 125 Pro Phe His Tyr Asn Arg Val Met Asn Pro Arg Arg Cys Leu Leu Met 130 135 140 Leu Leu Gly Ser Cys Thr Ile Ser His Leu His Ser Leu Leu Arg Val 145 150 155 160 Leu Leu Met Ser Arg Leu Ser Phe Cys Ala Ser His Val Ile Lys His 165 170 175 Phe Phe Cys Asp Thr Gln Pro Val Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190 Ser Ser Ser Gln Ile Val Val Met Thr Glu Thr Leu Ala Val Ile Ala 195 200 205 Thr Pro Phe Leu Cys Ile Leu Phe Ser Tyr Leu Arg Ile Ile Val Thr 210 215 220 Val Leu Arg Ile Pro Ser Ala Ala Gly Lys Trp Lys Ala Phe Ser Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Ala Leu Thr Tyr Gly Ser Val Ile 245 250 255 Tyr Val Tyr Phe Arg Pro Leu Ser Met Tyr Ser Val Val Lys Asp Arg

Page 4044

260

069269_0225_SL.TXT 265 270

Val Ala Thr Val Met Tyr Thr Val Val Thr Pro Met 280 Leu 285 Asn Pro Phe 275 Ile Tyr Ser Leu Arg Asn Lys Asp Met Asn Arg Gly Leu Lys Lys Leu 290 295 300 Arg Asn Arg Ile His Leu 305 310

<210> 3613 <211> 905 <212> DNA <213> Felis catus <400> 3613

aggggaaacc agagtcacat cacagaattc ctccttctgg gactgaccag tgaccccaaa 60 tatcaggagt ggctctttac cagctttctg gccatgtatc tggtcaacgt ggctggcaac 120 tcagtcatca ttgcagccat ccggggggac acccgcctcc acacccccat gtacttcttc 180 ctctccaatc tgtccctggt ggacatctgc tttacaaatg tcattgtgcc acggatgctg 240 gcaaacatgc tgaacaagac caagaagatc tcctttgccc agtgcctcac acagatgtat 300 ttctttgtga cctgtgcgat cactgacagc ttcctcctgg ctgccatggc tattgaccgc 360 tacatggcca tctgtaaccc actgcattac accacgacca tgagccccca gcgctgtctc 420 ctgctggtga cggtgtcctg ggtgctgtcc caccttcact cactcaccca cacgattctc 480 atggcccgcc tctccttctg tgggcccaac gtcatccacc acttcttctg tgacgtccag 540 ccactgctga cgctctcctg ctctgacacc tctgtcaatg agcttttggc cttcacagag 600 ggctccttgg tgatcatgag tcctttcatc ttgatcattg tctcttacgt ccacatcacc 660 cgtgccgttc tgagggtccc ttctcgagga ggcaggcaca aggtcttctc cacctgtggg 720 tcccacctca cagttgtggc actcttctat gggactgcca tctctgtgta cattcgcccc 780 tcatctacct actcagtgac aaaggacagt gtggtcactg ttatttatac tgtggtaatc 840 cccatgttga acccttttat ctacagtctt aggaacaagg acatgaaaca agccttgaga 900

aagct 905

Page 4045

069269_0225_SL.TXT <210> 3614 <211> 302 <212> PRT <213> Felis catus

<400> 3614 Arg 1 Gly Asn Gln Ser 5 His Ile Thr Glu Phe Leu Leu Leu Gly Leu Thr 10 15 Ser Asp Pro Lys Tyr Gln Glu Trp Leu Phe Thr Ser Phe Leu Ala Met 20 25 30 Tyr Leu Val Asn Val Ala Gly Asn Ser Val Ile Ile Ala Ala Ile Arg 35 40 45 Gly Asp Thr Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Val Asp Ile Cys Phe Thr Asn Val Ile Val Pro Arg Met Leu 65 70 75 80 Ala Asn Met Leu Asn Lys Thr Lys Lys Ile Ser Phe Ala Gln Cys Leu 85 90 95 Thr Gln Met Tyr Phe Phe Val Thr Cys Ala Ile Thr Asp Ser Phe Leu 100 105 110 Leu Ala Ala Met Ala Ile Asp Arg Tyr Met Ala Ile Cys Asn Pro Leu 115 120 125 His Tyr Thr Thr Thr Met Ser Pro Gln Arg Cys Leu Leu Leu Val Thr 130 135 140 Val Ser Trp Val Leu Ser His Leu His Ser Leu Thr His Thr Ile Leu 145 150 155 160 Met Ala Arg Leu Ser Phe Cys Gly Pro Asn Val Ile His His Phe Phe 165 170 175

Page 4046

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Cys Asp Val Gln Pro Leu Leu 180 Thr Leu Ser Cys Ser Asp Thr Ser Val 185 190 Asn Glu Leu Leu Ala Phe Thr Glu Gly Ser Leu Val Ile Met Ser Pro 195 200 205 Phe Ile Leu Ile Ile Val Ser Tyr Val His Ile Thr Arg Ala Val Leu 210 215 220 Arg Val Pro Ser Arg Gly Gly Arg His Lys Val Phe Ser Thr Cys Gly 225 230 235 240 Ser His Leu Thr Val Val Ala Leu Phe Tyr Gly Thr Ala Ile Ser Val 245 250 255 Tyr Ile Arg Pro Ser Ser Thr Tyr Ser Val Thr Lys Asp Ser Val Val 260 265 270 Thr Val Ile Tyr Thr Val Val Ile Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Lys Asp Met Lys Gln Ala Leu Arg Lys Leu 290 295 300

<210> 3615 <211> 921 <212> DNA <213> Felis catus <400> 3615

cctgctgaat tcatcctcct gggcatcacg gatcgctggg acctacgtgt gaccctcttc 60 ctgattttcc taccagtcta cctggtgagc ctgctgggaa atgtgggcat ggtgctgcta 120 atccaagtgg atgcccggct ccacacacct atgtacttct tcctggccaa cctctccctg 180 ctggacacct gctattcctc agccatcgcc cccaagatgc tggtggactt actgctgccc 240 cacgccacca tcccttacac ggcctgtgcc ctccagatgt ttgtgttcgc aggactggct 300 gatgccgagt gttgcctgtt ggcagcgatg gcctatgacc gctacgtggc catcggaagc 360 cctcttctct acacaacagc catgtcgcag cgtgtatgcc tggccttgct gggagcatca 420

Page 4047

069269_0225_SL.TXT

ggcctgggcg gggcagtgag tgccattgtc cacacgactt tcaccttccg cctgaatttc 480 tgccgctccc gggaggtcaa cagcttcttc tgtgatatcc ctccactgct ggccatctcc 540 tgcaatgaca ccagtctcaa tgagctcctc ctctttgcca tctgtggctt catccagaca 600 gccacggtgt tggttattgt cgtgtcatat ggtttcattg ccggggctgt gattcgcatg 660 ccctcggctg agggccgtcg gcgagcagcc tctacctgtg gctcccacct cacggctgta 720 accatgctgt atgggacact cactttcatg tacctgcgtc ccagctccag ctatgccctg 780 gacactgaca agatggcatc cgtgttctac actcttgtca tcccagctct taaccctctc 840 atctacagcc tccgcaacaa ggaggtcaag gaggcagtca aaagaacctg gagccgattc 900 cgccgtccag gtccggagca c 921

<210> 3616 <211> 307 <212> PRT <213> Felis catus <400> 3616

Pro Ala Glu Phe Ile Leu Leu Gly Ile Thr Asp Arg Trp Asp Leu Arg 1 5 10 15 Val Thr Leu Phe Leu Ile Phe Leu Pro Val Tyr Leu Val Ser Leu Leu 20 25 30 Gly Asn Val Gly Met Val Leu Leu Ile Gln Val Asp Ala Arg Leu His 35 40 45 Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser Leu Leu Asp Thr Cys 50 55 60 Tyr Ser Ser Ala Ile Ala Pro Lys Met Leu Val Asp Leu Leu Leu Pro 65 70 75 80 His Ala Thr Ile Pro Tyr Thr Ala Cys Ala Leu Gln Met Phe Val Phe 85 90 95 Ala Gly Leu Ala Asp Ala Glu Cys Cys Leu Leu Ala Ala Met Ala Tyr 100 105 110

Page 4048

069269_0225_SL.TXT

Asp Arg Tyr Val Ala Ile Gly Ser Pro Leu Leu Tyr Thr Thr Ala Met 115 120 125 Ser Gln Arg Val Cys Leu Ala Leu Leu Gly Ala Ser Gly Leu Gly Gly 130 135 140 Ala Val Ser Ala Ile Val His Thr Thr Phe Thr Phe Arg Leu Asn Phe 145 150 155 160 Cys Arg Ser Arg Glu Val Asn Ser Phe Phe Cys Asp Ile Pro Pro Leu 165 170 175 Leu Ala Ile Ser Cys Asn Asp Thr Ser Leu Asn Glu Leu Leu Leu Phe 180 185 190 Ala Ile Cys Gly Phe Ile Gln Thr Ala Thr Val Leu Val Ile Val Val 195 200 205 Ser Tyr Gly Phe Ile Ala Gly Ala Val Ile Arg Met Pro Ser Ala Glu 210 215 220 Gly Arg Arg Arg Ala Ala Ser Thr Cys Gly Ser His Leu Thr Ala Val 225 230 235 240 Thr Met Leu Tyr Gly Thr Leu Thr Phe Met Tyr Leu Arg Pro Ser Ser 245 250 255 Ser Tyr Ala Leu Asp Thr Asp Lys Met Ala Ser Val Phe Tyr Thr Leu 260 265 270 Val Ile Pro Ala Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Glu 275 280 285 Val Lys Glu Ala Val Lys Arg Thr Trp Ser Arg Phe Arg Arg Pro Gly 290 295 300

Pro Glu His 305

Page 4049

069269_0225_SL.TXT ttcagaggga tctctttggg ggctgccgta gtcctttgct ggcccacgac cctgggtgta ccgccacccc gaccgcatgg gtccttctgt gctctcgtgc ggtggtcact ccggctgccg agtggtgagc tgaggcagag ccctgtgatc cggacggagg <210> 3617 <211> 951 <212> DNA <213> Felis catus <400> 3617 atggatgcta ccaatgagtc agtcctgaac agcggcggcc ctgggtaatg gactcatcgt tacttcctgc tggcccatct aagatgttgg ccaacttgtt cagatgtact tcttctttgc tatgaccgct atgtggccat gtgtgcaaag ccctggtggg atcctgctta tggcccgcct gaccaccagc ctctcttaag ttcactgagg gtgccgcggt gccatcgcag ctgcggtgct acctgtggct cccacctggc ttccagccca catctcggta gtagtcaccc ccacactaaa gcactccgag ccctcttcac <210> 3618 <211> 316 <212> PRT <213> Felis catus <400> 3618

Met Asp Ala Thr Asn Glu Ser Ser Glu 1 5 gccccattca tcctgctggg actgacaaca 60 ttattcttgg tcctgtacgt agcaggcatc 120 cgggccagtc cagcccttcg tgcacccatg 180 gacctctgct ttacctccgt cactgtaccc 240 cgctccatct ccgtggctgg ctgtctgacc 300 accgatagct gtctcctggc cgccatggcc 360 ctccactatg ccacaaggat gtcccgggcc 420 ctggtgtccc acgtccactc cctcctgcat 480 gcctcccacc atgtgcccca cttcttctgt 540 tctgacaccc gccacatcca gctgctcatc 600 cccttcctgc tcatccttac ctcctacggg 660 tcagcctctg ggaggctccg ggctgtgtcc 720 ctcttctatg ggacagtcat tgcagtgtac 780 cggggccgtg tggccactgt catgtacacc 840 tatagcctcc ggaaccgtga cgtgcagggg 900 atctcagctg gcgactccta a 951

Gly Leu Thr Thr Ser Pro Glu Gln Arg 20 25

Gly Ala Pro Phe Ile Leu Leu 10 15 Arg Pro Leu Phe Gly Leu Phe

Page 4050

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Leu Val Leu 35 Tyr Val Ala Gly Ile Leu Gly Asn Gly Leu Ile Val Ala 40 45 Ala Val Arg Ala Ser Pro Ala Leu Arg Ala Pro Met Tyr Phe Leu Leu 50 55 60 Ala His Leu Ser Phe Ala Asp Leu Cys Phe Thr Ser Val Thr Val Pro 65 70 75 80 Lys Met Leu Ala Asn Leu Leu Ala His Asp Arg Ser Ile Ser Val Ala 85 90 95 Gly Cys Leu Thr Gln Met Tyr Phe Phe Phe Ala Leu Gly Val Thr Asp 100 105 110 Ser Cys Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Arg 115 120 125 His Pro Leu His Tyr Ala Thr Arg Met Ser Arg Ala Val Cys Lys Ala 130 135 140 Leu Val Gly Thr Ala Trp Leu Val Ser His Val His Ser Leu Leu His 145 150 155 160 Ile Leu Leu Met Ala Arg Leu Ser Phe Cys Ala Ser His His Val Pro 165 170 175 His Phe Phe Cys Asp His Gln Pro Leu Leu Arg Leu Ser Cys Ser Asp 180 185 190 Thr Arg His Ile Gln Leu Leu Ile Phe Thr Glu Gly Ala Ala Val Val 195 200 205 Val Thr Pro Phe Leu Leu Ile Leu Thr Ser Tyr Gly Ala Ile Ala Ala 210 215 220 Ala Val Leu Arg Leu Pro Ser Ala Ser Gly Arg Leu Arg Ala Val Ser 225 230 235 240

Page 4051

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Thr Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Val 245 250 255 Ile Ala Val Tyr Phe Gln Pro Thr Ser Arg Tyr Glu Ala Glu Arg Gly 260 265 270 Arg Val Ala Thr Val Met Tyr Thr Val Val Thr Pro Thr Leu Asn Pro 275 280 285 Val Ile Tyr Ser Leu Arg Asn Arg Asp Val Gln Gly Ala Leu Arg Ala 290 295 300 Leu Phe Thr Gly Arg Arg Ile Ser Ala Gly Asp Ser 305 310 315

<210> 3619 <211> 941 <212> DNA <213> Felis catus <400> 3619 atgacaagaa gaaatcaaac tattgtctca gtcttcctcc ttctgggcct gccaattgag ccagagcaac aaaatccgtt ttatgtcctg ttcctggcca tgtatcttat caccgtactg gggaatctcc tcataatttt cctgatttgc ctggactccc acctgcacac acccatgtat ttttttctca gcaatttgtc tttctctgat atctgcttct cttctgtgac cattccgaaa ttgttgcaaa ccatgcagag ccaagactca tccatcccct atgccggctg cctgacccaa atgtacttct ttctgttttt tgcagacctg gagagtttcc tcctagtggc catggcctat gaccgctatg tggccatctg cttccccctc cactacacca ttatcatgag ctccaagctc tgtctctccc tggttgtgct gtcctgggtg ctgaccacgt tccatgctat gttacacact ctcctcatgg ccagattgtg tttctgtgct gacaacataa tcccccactt tttctgtgac atgtctgctc tgctgaagct ggcgtgctct gacactcgag tcaatgagtt ggtgatattt atcatgggag ggctcattct cgtcatccca ttcctactca tcgtcatgtc ttatgcacgg attgtgtcct ccatcctcag ggtcccttct gccaggggca tccgcaaggc cttctccacc

120

180

240

300

360

420

480

540

600

660

720

Page 4052

069269_0225_SL.TXT tgtggctccc acctctccgt gctgtctctt ttctatggga cagttattgg cctctacttg tgcccttcag ctaataattc tgctgttaag gagactgtga tggccgtgat gtacactgtg gtcaccccca tgctgaatcc cttcatctac agcctgagga acagagacat gatgggagct ctgggaagac tccttttcaa aaagaaaatt tccttctctg t

780

840

900

941 <210> 3620 <211> 314 <212> PRT <213> Felis catus <400> 3620

Met Thr Arg Arg Asn Gln Thr Ile Val Ser Val Phe Leu Leu Leu Gly 1 5 10 15 Leu Pro Ile Glu Pro Glu Gln Gln Asn Pro Phe Tyr Val Leu Phe Leu 20 25 30 Ala Met Tyr Leu Ile Thr Val Leu Gly Asn Leu Leu Ile Ile Phe Leu 35 40 45 Ile Cys Leu Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ser Asp Ile Cys Phe Ser Ser Val Thr Ile Pro Lys 65 70 75 80 Leu Leu Gln Thr Met Gln Ser Gln Asp Ser Ser Ile Pro Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Met Tyr Phe Phe Leu Phe Phe Ala Asp Leu Glu Ser 100 105 110 Phe Leu Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe 115 120 125 Pro Leu His Tyr Thr Ile Ile Met Ser Ser Lys Leu Cys Leu Ser Leu 130 135 140 Val Val Leu Ser Trp Val Leu Thr Thr Phe His Ala Met Leu His Thr

Page 4053

0 6926 9_02 25_S L.TX T 145 150 155 160 Leu Leu Met Ala Arg Leu Cys Phe Cys Ala Asp Asn Ile Ile Pro His 165 170 175 Phe Phe Cys Asp Met Ser Ala Leu Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 Arg Val Asn Glu Leu Val Ile Phe Ile Met Gly Gly Leu Ile Leu Val 195 200 205 Ile Pro Phe Leu Leu Ile Val Met Ser Tyr Ala Arg Ile Val Ser Ser 210 215 220 Ile Leu Arg Val Pro Ser Ala Arg Gly Ile Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Leu Ser Leu Phe Tyr Gly Thr Val Ile 245 250 255 Gly Leu Tyr Leu Cys Pro Ser Ala Asn Asn Ser Ala Val Lys Glu Thr 260 265 270 Val Met Ala Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Met Gly Ala Leu Gly Arg Leu 290 295 300 Leu Phe Lys Lys Lys Ile Ser Phe Ser Val

305 310 <210> 3621 <211> 945 <212> DNA <213> Felis catus <400> 3621 atgacaggaa agaatcaaac tgttgtctta gaattcctcc tcctgggcct gcccatcaag tcagagctac gagaccagtt ctatgccctg ttcctgctca tgtatgttac caccatcctg

120

Page 4054

069269_0225_SL.TXT gggaacctgc tcatcatcgt tctcatttgc ctggactccc gcctccacac gcccatgtat ttgtttctca gtaacttgtc cttctctgac ctctgcttct cctctgtcac aatgcccaat ctgctgcaga acatgcagag ccaggtcccg tccatcccct atgccggctg cctgacccag atgtacttct tcctattttt tggagacctg gagagcttcc tcctggtggc catggcctat gaccgctata tggccatctg tttccccctg cactacacca ccatcatgag ccccaagctc tgtctctcct tggtggtgct gtgctgggtg ctgactgctg cccatgccat gttgcacacc ctgctcatgg ccaagctgtc cttctgtgcc gacaacataa tcccccactt tttctgtgac atgtctgctc tgctgaagct ggcctgctct gacactcgaa tcaatgagtt ggtgatattt atcatgggag ggctcattct cgtcatccca ttcctattca ttgtcatgtc ttatgcacgg attgtgtcct ccatcctcag ggtcccttct gccaggggca tccgcaaggc cttctccacc tgtggctccc acctctccgt gctgtctctt ttctatggga cagttatcgg cctctacttg tgcccttcag ctaataattc tgctgttaag gagactgtga tggccgtgat gtacactgtg gtcaccccca tgctgaatcc cttcatctac agcctgagga acagagacat gaagggagcc ctgggaagag tcttttgtgg aaagaaaatt cccttctctg tatga <210> 3622 <211> 314 <212> PRT <213> Felis catus

180

240

300

360

420

480

540

600

660

720

780

840

900

945 <400> 3622

Met Thr Gly Lys Asn Gln Thr Val Val Leu Glu Phe Leu Leu Leu Gly 1 5 10 15 Leu Pro Ile Lys Ser Glu Leu Arg Asp Gln Phe Tyr Ala Leu Phe Leu 20 25 30 Leu Met Tyr Val Thr Thr Ile Leu Gly Asn Leu Leu Ile Ile Val Leu 35 40 45 Ile Cys Leu Asp Ser Arg Leu His Thr Pro Met Tyr Leu Phe Leu Ser 50 55 60

Page 4055

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Asn 65 Leu Ser Phe Ser Asp Leu Cys Phe Ser Ser Val Thr Met Pro Asn 70 75 80 Leu Leu Gln Asn Met Gln Ser Gln Val Pro Ser Ile Pro Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Met Tyr Phe Phe Leu Phe Phe Gly Asp Leu Glu Ser 100 105 110 Phe Leu Leu Val Ala Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Phe 115 120 125 Pro Leu His Tyr Thr Thr Ile Met Ser Pro Lys Leu Cys Leu Ser Leu 130 135 140 Val Val Leu Cys Trp Val Leu Thr Ala Ala His Ala Met Leu His Thr 145 150 155 160 Leu Leu Met Ala Lys Leu Ser Phe Cys Ala Asp Asn Ile Ile Pro His 165 170 175 Phe Phe Cys Asp Met Ser Ala Leu Leu Lys Leu Ala Cys Ser Asp Thr 180 185 190 Arg Ile Asn Glu Leu Val Ile Phe Ile Met Gly Gly Leu Ile Leu Val 195 200 205 Ile Pro Phe Leu Phe Ile Val Met Ser Tyr Ala Arg Ile Val Ser Ser 210 215 220 Ile Leu Arg Val Pro Ser Ala Arg Gly Ile Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Leu Ser Leu Phe Tyr Gly Thr Val Ile 245 250 255 Gly Leu Tyr Leu Cys Pro Ser Ala Asn Asn Ser Ala Val Lys Glu Thr 260 265 270

Page 4056

0 6926 9_02 25_S iL.TX T Val Met Ala Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Met Lys Gly Ala Leu Gly Arg Val 290 295 300 Phe Cys Gly Lys Lys Ile Pro Phe Ser Val 305 310

<210> 3623 <211> 945 <212> DNA <213> Felis catus <400> 3623

atgaaaatgg gaaaccaaag tgtcatctca gagttcctcc tcctgggtct gcctattgag 60 ccagagctgc gggaccagtt ctatgccctg ttcctgctca tgtatgttac caccatcctg 120 gggaacctgc tcatcatcat cctcattctc ctggactccc gcctccacac gcccatgtat 180 ttgtttctca gtaacttgtc cttctctgac ctctgcttct cctctgtcac aatgcccaaa 240 ctgctgcaga acatgcagag ccaggtcccg tccatcccct atgccggctg cctggcccag 300 atgtacttct tcttgctttt tgcagacctg gagagcttcc tcctggtggc catggcctat 360 gaccgctatg tggccatttg ctttcccctg cactacacca ccatcatgag ccccaagctc 420 tgtctctccc tggtggtgct gtcctgggtg ctaaccactt ttatctcttt attgcacaca 480 ctactcatgg ctcggctgtc cttctgtgct gataatgtga ttcctcactt tttctgtgac 540 atgtcagctc tgctaaagtt ggcctgctct gacattcata taaatgaaat ggtgatattt 600 attttgggag ggcttgtcat tattgttcca ttcctgttga tctttttatc ctatgcacgg 660 attgtgtcct ccatcctcag ggtcccttct gccaggggca tccgcaaggc cttctccacc 720 tgtggctccc acctctccgt ggtgtctctc ttctacggga caatcattgg cctctacttg 780 tgcccttcag acaacaattc tactgttaag gagactgtca tggccgtgat gtacactgtg 840 gtcaccccta tgctgaatcc cttcatctac agcctgagga atcgggacat aaagggagcc 900 ttaggaagag tatgttccaa atggacgatt cagctttctc tggga 945

<210> 3624

Page 4057

069269_0225_SL.TXT <211> 315 <212> PRT <213> Felis catus

<400> 3624 Asn Gln Ser Val Ile Ser Glu Phe Leu Leu Leu Gly Met 1 Lys Met Gly 5 10 15 Leu Pro Ile Glu Pro Glu Leu Arg Asp Gln Phe Tyr Ala Leu Phe Leu 20 25 30 Leu Met Tyr Val Thr Thr Ile Leu Gly Asn Leu Leu Ile Ile Ile Leu 35 40 45 Ile Leu Leu Asp Ser Arg Leu His Thr Pro Met Tyr Leu Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ser Asp Leu Cys Phe Ser Ser Val Thr Met Pro Lys 65 70 75 80 Leu Leu Gln Asn Met Gln Ser Gln Val Pro Ser Ile Pro Tyr Ala Gly 85 90 95 Cys Leu Ala Gln Met Tyr Phe Phe Leu Leu Phe Ala Asp Leu Glu Ser 100 105 110 Phe Leu Leu Val Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Phe 115 120 125 Pro Leu His Tyr Thr Thr Ile Met Ser Pro Lys Leu Cys Leu Ser Leu 130 135 140 Val Val Leu Ser Trp Val Leu Thr Thr Phe Ile Ser Leu Leu His Thr 145 150 155 160 Leu Leu Met Ala Arg Leu Ser Phe Cys Ala Asp Asn Val Ile Pro His 165 170 175 Phe Phe Cys Asp Met Ser Ala Leu Leu Lys Leu Ala Cys Ser Asp Ile 180 185 190

Page 4058

069269_0225_SL.TXT

His Ile Asn 195 Glu Met Val Ile Phe Ile Leu Gly Gly Leu Val Ile Ile 200 205 Val Pro Phe Leu Leu Ile Phe Leu Ser Tyr Ala Arg Ile Val Ser Ser 210 215 220 Ile Leu Arg Val Pro Ser Ala Arg Gly Ile Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Gly Leu Tyr Leu Cys Pro Ser Asp Asn Asn Ser Thr Val Lys Glu Thr 260 265 270 Val Met Ala Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Gly Ala Leu Gly Arg Val 290 295 300 Cys Ser Lys Trp Thr Ile Gln Leu Ser Leu Gly 305 310 315

<210> 3625 <211> 944 <212> DNA <213> Felis catus <400> 3625

tcacacctct tggggtgcag ccctccatct gagccccctt ttcagggcgc ccttgacctc 60 cttgttgcga aggctgtaga tgaaagggtt caaggtcggt gtgagcacag catagaccac 120 gctggccagg cggtcatagc gggctgagta ggcggaggac ggccggaaat agacggagag 180 gacagagccg aagaaaagcg acaccaccac caggtgggcc ccgcaggtgg cgaaggcgcg 240 gcgccggccc ccggccgccc gcactcccag caccgcgacg aggatgcgcg cgtaggacag 300 cgacacgagg agcagcgggg tgagcaccac ggccaggccc tcggagaaga tggcagcctc 360 cgcggtcgcc gtgtccgagg tcgccaggct cagcatcacc gtcatgtcac agaagaagtg 420

Page 4059

069269_0225_SL.TXT

gcgcacaggg gcgggcacgg gtaggagagc gccgagatga gcagcgtgtg cagcagcgag 480 tgcaggtggg ccaccgccca ggacgtggtc accagcgccg cgcagcgccg gggcgtcatg 540 accgcgcagt agtgcagggg gcggcagacg gccaccgcgc ggtcgtagga catggctgcc 600 agcaggtagc tctcggtgat gcccagagcc acgaagaagt acatctggga aaagcatccc 660 tggaaggaca cggcctggcg cgggtggagc aagccggcca gcagtctggg gacggtgaca 720 gtggtaaagc agacgtccac gaggctcagg tgacccagga aatagtacat gggggagcgg 780 agggccccat ccgacctcac caccaccacc atggccaggt tgcccagggc attgagcagg 840 tagacgccga ggaagagcag gaagagcagc gggtggatgt ctgttccatc caccaggccg 900 aggaggagga attctggggc cgtcgtgagg ttggccaggg ccat 944

<210> 3626 <211> 313 <212> PRT <213> Felis catus

<400> 3626 His Asp Gly Pro Arg Ile Pro Pro Pro Arg Pro Gly Pro 1 Gly Gln Pro 5 10 15 Gly Gly Trp Asn Arg His Pro Pro Ala Ala Leu Pro Ala Leu Pro Arg 20 25 30 Arg Leu Pro Ala Gln Cys Pro Gly Gln Pro Gly His Gly Gly Gly Gly 35 40 45 Glu Val Gly Trp Gly Pro Pro Leu Pro His Val Leu Phe Pro Gly Ser 50 55 60 Pro Glu Pro Arg Gly Arg Leu Leu Tyr His Cys His Arg Pro Gln Thr 65 70 75 80 Ala Gly Arg Leu Ala Pro Pro Ala Pro Gly Arg Val Leu Pro Gly Met 85 90 95 Leu Phe Pro Asp Val Leu Leu Arg Gly Ser Gly His His Arg Glu Leu 100 105 110

Page 4060

069269_0225_SL.TXT

Pro Ala Gly 115 Ser His Val Leu Arg Pro Arg Gly Gly Arg Leu Pro Pro 120 125 Pro Ala Leu Leu Arg Gly His Asp Ala Pro Ala Leu Arg Gly Ala Gly 130 135 140 Asp His Val Leu Gly Gly Gly Pro Pro Ala Leu Ala Ala Ala His Ala 145 150 155 160 Ala His Leu Gly Ala Leu Leu Pro Val Pro Ala Pro Val Arg His Phe 165 170 175 Phe Cys Asp Met Thr Val Met Leu Ser Leu Ala Thr Ser Asp Thr Ala 180 185 190 Thr Ala Glu Ala Ala Ile Phe Ser Glu Gly Leu Ala Val Val Leu Thr 195 200 205 Pro Leu Leu Leu Val Ser Leu Ser Tyr Ala Arg Ile Leu Val Ala Val 210 215 220 Leu Gly Val Arg Ala Ala Gly Gly Arg Arg Arg Ala Phe Ala Thr Cys 225 230 235 240 Gly Ala His Leu Val Val Val Ser Leu Phe Phe Gly Ser Val Leu Ser 245 250 255 Val Tyr Phe Arg Pro Ser Ser Ala Tyr Ser Ala Arg Tyr Asp Arg Leu 260 265 270 Ala Ser Val Val Tyr Ala Val Leu Thr Pro Thr Leu Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Leu Lys Arg Gly Leu 290 295 300 Arg Trp Arg Ala Ala Pro Gln Glu Val 305 310

Page 4061

069269_0225_SL.TXT <210> 3627 <211> 948 <212> DNA <213> Felis catus <400> 3627

tcattcagga ggccgcttcc ccatcagcac ccttttcagg gcgccctgca catcagggtt 60 ccggaggcta tagatgagtg ggttcaacat ggggctgagg atagtattga ggatcccaat 120 ccctttgtct ttgtctgagg ctgacactga gcccagacgc atgtaactga agaagccagt 180 tccataaaag atacagacca cggtgaggtg ggagccacac gtggagaagg ccttcttcct 240 cccctctgct gaacggattc gtagcactgc agctgtgacg tgggcgtaag acactgagat 300 gaggatcatg gggaacaccc ccatgaaagt ggcccccaca aaaagcagct gcccattgag 360 gtggatactg gagcaggaga gctggaaaag gggtgggagg tcgcagtaga agtggttgac 420 cacattaggg ccgcagaagt caagcacaga cagggccact gtgtgagtca gagcattgat 480 aaaggagata gtgcagcaaa tggccaccag ggcaccccgg acttcacggc gcatgcgggt 540 gctgtaggtg aggggctggc agatggccag gtagcggtca taggccatgg ctgtcaggag 600 gtgacagtcc acaccggcca ggaggtggaa gaagaagagc tgtgaaaggc aggcagcgta 660 ggggactctg cactgggggg gcaggagaca tgctagcatt ggagggacag taacagtgat 720 gcatccaatg tccagcagag ataggttccc caagaagtag tacatgggag tgtggagttt 780 gggctccaca aagatggcag ccaggatgct gaagttgccc cctatggtga gtacataggc 840 aaagaggaag acgacaaaaa ggatgggttt cagtcttacg ttttctgtca ggccaagaag 900 gatgaactca gtgaccgttg tcctgttccc ccaggcgcct ggctccat 948

<210> 3628 <211> 315 <212> PRT <213> Felis catus <400> 3628

Met Glu Pro Gly Ala Trp Gly Asn Arg Thr Thr Val Thr Glu Phe Ile

1 5 10 15

Leu Leu Gly Leu Thr Glu Asn Val Arg Leu Lys Pro Ile Leu Phe Val

Page 4062

069269_0225_SL.TXT 25 30

Val Phe Leu 35 Phe Ala Tyr Val Leu Thr Ile Gly Gly Asn Phe Ser Ile 40 45 Leu Ala Ala Ile Phe Val Glu Pro Lys Leu His Thr Pro Met Tyr Tyr 50 55 60 Phe Leu Gly Asn Leu Ser Leu Leu Asp Ile Gly Cys Ile Thr Val Thr 65 70 75 80 Val Pro Pro Met Leu Ala Cys Leu Leu Pro Pro Gln Cys Arg Val Pro 85 90 95 Tyr Ala Ala Cys Leu Ser Gln Leu Phe Phe Phe His Leu Leu Ala Gly 100 105 110 Val Asp Cys His Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala 115 120 125 Ile Cys Gln Pro Leu Thr Tyr Ser Thr Arg Met Arg Arg Glu Val Arg 130 135 140 Gly Ala Leu Val Ala Ile Cys Cys Thr Ile Ser Phe Ile Asn Ala Leu 145 150 155 160 Thr His Thr Val Ala Leu Ser Val Leu Asp Phe Cys Gly Pro Asn Val 165 170 175 Val Asn His Phe Tyr Cys Asp Leu Pro Pro Leu Phe Gln Leu Ser Cys 180 185 190 Ser Ser Ile His Leu Asn Gly Gln Leu Leu Phe Val Gly Ala Thr Phe 195 200 205 Met Gly Val Phe Pro Met Ile Leu Ile Ser Val Ser Tyr Ala His Val 210 215 220 Thr Ala Ala Val Leu Arg Ile Arg Ser Ala Glu Gly Arg Lys Lys Ala

Page 4063

0 6926 9_02 25_S L.TX T 225 230 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Cys Ile Phe Tyr Gly 245 250 255 Thr Gly Phe Phe Ser Tyr Met Arg Leu Gly Ser Val Ser Ala Ser Asp 260 265 270 Lys Asp Lys Gly Ile Gly Ile Leu Asn Thr Ile Leu Ser Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Pro Asp Val Gln Gly Ala Leu 290 295 300 Lys Arg Val Leu Met Gly Lys Arg Pro Pro Glu 305 310 315

<210> 3629 <211> 899 <212> DNA <213> Felis catus <400> 3629

tccctgcgaa cacccgctgc agggcgccct gcacatcagg gttccggaga ctgtagatga 60 gtgggttcag catggggctg atgacagtgt tgaggatgcc aatccctttg tctttgtccg 120 aagcctccac tgagcccagc ctcatgtagc tgaagacgcc tgtcccgtag aatacgctga 180 caaccgtgag gtgggagcca cacgtggaga aggctttctt cctgccctca gcagagcgga 240 ttcgcaggac tgcggctgcc acgtgtgcat aggacacagt gatgaggacc agtggggcca 300 cacccatgaa ggctgctgct acaaagagca gcagctcatt gagctgggtg ctggagcagg 360 agagctggaa gagctgtggg aggtcacagt agaagtgatt gatcacatgg gggccacaga 420 agtcaagagt agataaggca acagtttggg tcagcgcgtt ggtgaaggaa aaggcacacg 480 acacgcccac tagcgcttgc tgaattcccc agctcatgcg ggtgctgtag gtgaggggct 540 ggcagatggc cagatagcgg tcataggcca tgactgtcag caggaagcag tccgcccctg 600 ccaggaggtg gaaactgaag agctgtgaga ggcaggcccc gtagggaatg cttctgttat 660 tggacatgaa gcgtctcagc atggcaggga cagtgacact gatgcacccg acatccagca 720

Page 4064

069269_0225_SL.TXT gggacaagtt ccccaggaag aagtacatgg gggtgtggag tttgggttcg gcgaggatgg cagccaggat gctgaggttg cccccaagag tagctacgta agcgagaagg aagacggtga agaggacggg ctgcagagct ggggtctctg acagacccag caggacaaac tcagtgaca

780

840

899 <210> 3630 <211> 300 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (300)..(300) <223> Any amino acid <400> 3630

Val Thr Glu Phe Val Leu Leu Gly Leu Ser Glu Thr Pro Ala Leu Gln 1 5 10 15 Pro Val Leu Phe Thr Val Phe Leu Leu Ala Tyr Val Ala Thr Leu Gly 20 25 30 Gly Asn Leu Ser Ile Leu Ala Ala Ile Leu Ala Glu Pro Lys Leu His 35 40 45 Thr Pro Met Tyr Phe Phe Leu Gly Asn Leu Ser Leu Leu Asp Val Gly 50 55 60 Cys Ile Ser Val Thr Val Pro Ala Met Leu Arg Arg Phe Met Ser Asn 65 70 75 80 Asn Arg Ser Ile Pro Tyr Gly Ala Cys Leu Ser Gln Leu Phe Ser Phe 85 90 95 His Leu Leu Ala Gly Ala Asp Cys Phe Leu Leu Thr Val Met Ala Tyr 100 105 110 Asp Arg Tyr Leu Ala Ile Cys Gln Pro Leu Thr Tyr Ser Thr Arg Met 115 120 125

Page 4065

Ser Trp 130 Gly Ile Gln Gln Ala 135 069269_0225_SL.TXT Leu Val Gly Val Ser Cys 140 Ala Phe Ser Phe Thr Asn Ala Leu Thr Gln Thr Val Ala Leu Ser Thr Leu Asp Phe 145 150 155 160 Cys Gly Pro His Val Ile Asn His Phe Tyr Cys Asp Leu Pro Gln Leu 165 170 175 Phe Gln Leu Ser Cys Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe 180 185 190 Val Ala Ala Ala Phe Met Gly Val Ala Pro Leu Val Leu Ile Thr Val 195 200 205 Ser Tyr Ala His Val Ala Ala Ala Val Leu Arg Ile Arg Ser Ala Glu 210 215 220 Gly Arg Lys Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val 225 230 235 240 Ser Val Phe Tyr Gly Thr Gly Val Phe Ser Tyr Met Arg Leu Gly Ser 245 250 255 Val Glu Ala Ser Asp Lys Asp Lys Gly Ile Gly Ile Leu Asn Thr Val 260 265 270 Ile Ser Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Pro Asp 275 280 285 Val Gln Gly Ala Leu Gln Arg Val Phe Ala Gly Xaa 290 295 300

<210> 3631 <211> 946 <212> DNA <213> Felis catus <400> 3631 atggacccag aatccaagac caatggaaca gctgttactg agttcatcct gctgggctta

Page 4066

069269_0225_SL.TXT gtggagacac cagggctacg gccagttgtc tttgtagtct tcctcttagc ctatctgctc actgttgggg gcaacctcag catcctggcc gccatcttgg tggagaccaa actccacacc cccatgtact tcttcctggg gaacctatcg gtgctggacg ttgggtgtat caccgtcact gttccttcaa tgttggctcg tctcctgtcc cacaagcata ctgttcccta tggagcctgc ctcacacagc ttttcttctt tcaccagttg gctggtgtgg actgcttcct gttgacagcc atggcctatg accgattcct ggccatctgc cagcccctca cctacagcac ccgaatgagc cagacagtcc agaggatatt ggtggctgtg tcctgggctt tagccttcac taatgcactg acccacacag tagccatatc caccctgaac ttctgtggtc ccaatgtgat caatcacttc tactgtgacc tcccacagct cttccagctc tcctgctcca gcacccaact caatgagctg ctactctttg gtctgggtat cctcatggca ggtgcacctg tgattctcat tgtcacctcc tacatccatg tggcagctgc agtcctacga atccgttctg ctgagggcag gaaaaaagcc ttctccacat gtggttctca cctcactgtg gttggcatat tctatgggac aggtgtcttc agctacatga ggctgggctc agtggaagct tcagacaaag acaaagggat tggcatcctc aacactgtca tcagccccat gctgaaccca ctcatctaca gccttcggaa ccctgatgta cagggggctc tgtggcaggt gctcacgggg aagcgagccc ttgcat <210> 3632 <211> 316 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (316)..(316) <223> Any amino acid

120

180

240

300

360

420

480

540

600

660

720

780

840

900

946

<400> 3632 Met Asp Pro Glu Ser Lys Thr Asn Gly Thr Ala Val Thr Glu Phe Ile 1 5 10 15 Leu Leu Gly Leu Val Glu Thr Pro Gly Leu Arg Pro Val Val Phe Val 20 25 30 Val Phe Leu Leu Ala Tyr Leu Leu Thr Val Gly Gly Asn Leu Ser Ile Page 406 7

069269_0225_SL.TXT 40 45

Leu Ala Ala Ile Leu Val Glu Thr Lys Leu His Thr 60 Pro Met Tyr Phe 50 55 Phe Leu Gly Asn Leu Ser Val Leu Asp Val Gly Cys Ile Thr Val Thr 65 70 75 80 Val Pro Ser Met Leu Ala Arg Leu Leu Ser His Lys His Thr Val Pro 85 90 95 Tyr Gly Ala Cys Leu Thr Gln Leu Phe Phe Phe His Gln Leu Ala Gly 100 105 110 Val Asp Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Phe Leu Ala 115 120 125 Ile Cys Gln Pro Leu Thr Tyr Ser Thr Arg Met Ser Gln Thr Val Gln 130 135 140 Arg Ile Leu Val Ala Val Ser Trp Ala Leu Ala Phe Thr Asn Ala Leu 145 150 155 160 Thr His Thr Val Ala Ile Ser Thr Leu Asn Phe Cys Gly Pro Asn Val 165 170 175 Ile Asn His Phe Tyr Cys Asp Leu Pro Gln Leu Phe Gln Leu Ser Cys 180 185 190 Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe Gly Leu Gly Ile Leu 195 200 205 Met Ala Gly Ala Pro Val Ile Leu Ile Val Thr Ser Tyr Ile His Val 210 215 220 Ala Ala Ala Val Leu Arg Ile Arg Ser Ala Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Gly Ile Phe Tyr Gly

Page 4068

245

255

069269_0225_SL.TXT

250

Thr Gly Val Phe Ser Tyr Met Arg Leu 265 Gly Ser Val Glu Ala 270 Ser Asp 260 Lys Asp Lys Gly Ile Gly Ile Leu Asn Thr Val Ile Ser Pro Met Leu 275 280 285 Asn Pro Leu Ile Tyr Ser Leu Arg Asn Pro Asp Val Gln Gly Ala Leu 290 295 300 Trp Gln Val Leu Thr Gly Lys Arg Ala Leu Ala Xaa 305 310 315

<210> 3633 <211> 948 <212> DNA <213> Felis catus <400> 3633 atgaagtcaa aatttgagta caatagaaca gccattactg agttcatcct gctgggctta gtggagacac cagacctgcg gccagttgtc tttgtagtct tcctcctttc ctacctgctc acagttgggg gcaacctcag catcctggcc gccatcttgg tggagcccaa actccacacc cccatgtact tcttcctggg gaacctatcg gtgctggaca ttgggtgcat cacagtcact attccctcaa tgttggctcg tctcctgtcc cacaagcgta ctgttcccta tggagcctgc ctcacacagc ttttcttctt tcaccttctc gttggggtgg actgcttcct tttgacagcc atggcctatg accgattcct ggccatctgc cagcccctca cctacagcac ccgaatgagc cagacagtcc agaggatatt ggtggctgtg tcctgggctt tagccttcac taatgcactg acccacacag tagccatatc caccctgaac ttctgtggtc ccaatgtgat caatcacttc tactgtgacc tcccacagct cttccagctc tcctgctcca gcacccaact caatgagttg ctgctctttg ctgtgggttt cataatggca ggtactcccc tggctctcat cgtcacctcc tatgcccatg tgacagctgc agtcctacga atccgttctg ctgagggcag gaagaaagcc ttctccacat gtggctctca tctcactgtg gttgccatat tctacggttc aggtatattt aattacatgc gactgggttc agccaagctt tcagacaagg ataaagcttt tggaattttt Page 4069

120

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480

540

600

660

720

780

840

069269_0225_SL.TXT aacaccgtca tcaaccccat gctgaatcca atcatctaca gcctcaggaa ccctgacgtg cagggtgccc tctggagagt gctcatgggg aggcggccac tggcttga

900

948 <210> 3634 <211> 315 <212> PRT <213> Felis catus <400> 3634

Met 1 Lys Ser Lys Phe 5 Glu Tyr Asn Arg Thr Ala Ile Thr Glu Phe Ile 10 15 Leu Leu Gly Leu Val Glu Thr Pro Asp Leu Arg Pro Val Val Phe Val 20 25 30 Val Phe Leu Leu Ser Tyr Leu Leu Thr Val Gly Gly Asn Leu Ser Ile 35 40 45 Leu Ala Ala Ile Leu Val Glu Pro Lys Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Val Leu Asp Ile Gly Cys Ile Thr Val Thr 65 70 75 80 Ile Pro Ser Met Leu Ala Arg Leu Leu Ser His Lys Arg Thr Val Pro 85 90 95 Tyr Gly Ala Cys Leu Thr Gln Leu Phe Phe Phe His Leu Leu Val Gly 100 105 110 Val Asp Cys Phe Leu Leu Thr Ala Met Ala Tyr Asp Arg Phe Leu Ala 115 120 125 Ile Cys Gln Pro Leu Thr Tyr Ser Thr Arg Met Ser Gln Thr Val Gln 130 135 140 Arg Ile Leu Val Ala Val Ser Trp Ala Leu Ala Phe Thr Asn Ala Leu 145 150 155 160

Page 4070

Thr His Thr Val Ala 165 Ile Ser 069269_0225_SL.TXT Thr Leu Asn Phe Cys Gly 170 Pro Asn 175 Val Ile Asn His Phe Tyr Cys Asp Leu Pro Gln Leu Phe Gln Leu Ser Cys 180 185 190 Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe Ala Val Gly Phe Ile 195 200 205 Met Ala Gly Thr Pro Leu Ala Leu Ile Val Thr Ser Tyr Ala His Val 210 215 220 Thr Ala Ala Val Leu Arg Ile Arg Ser Ala Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ala Ile Phe Tyr Gly 245 250 255 Ser Gly Ile Phe Asn Tyr Met Arg Leu Gly Ser Ala Lys Leu Ser Asp 260 265 270 Lys Asp Lys Ala Phe Gly Ile Phe Asn Thr Val Ile Asn Pro Met Leu 275 280 285 Asn Pro Ile Ile Tyr Ser Leu Arg Asn Pro Asp Val Gln Gly Ala Leu 290 295 300 Trp Arg Val Leu Met Gly Arg Arg Pro Leu Ala 305 310 315

<210> 3635 <211> 948 <212> DNA <213> Felis catus <400> 3635 atggaaccag aagttggggt taacaggaca tctgttactg agttcattct actcggccta gtggaaacag aacagctgca gtctgtggtc tttgtagtct tcctctttgc ctatctgctc acagttgggg gcaacctcag catcctggcc gccatcttgg tggagcccaa actccacacc

120

180

Page 4071

069269_0225_SL.TXT

cccatgtact tcttcctggg gaacctatcg gtgctggacg ttgggtgcat caccgtcact 240 gttccctcaa tgttggcccg tctcctgtcc cacaagcgta ccgttcccta tagagcctgc 300 ctcacacagc ttttcttctt tcacctcctg gctggtatgg actgcttcct attgacagtg 360 atggcctatg accgattctt ggccatctgc cggcccctca cctacagcac ccaaatgagc 420 aagacagtcc agaggatgtt ggtggttgtg tcctgggctt tgggtttcac caatgcatta 480 aatcacactc ttaccctaac caccctgaac ttctgtggtc ccaatgtgat caatcacttc 540 tactgtgacc tcccacagct cttccagctc tcctgctcca gcacccaact caatgagctg 600 ctgctcttcg tagcagcagc cttcatggct gtaaccccct tggtcctcat cactgtgtcc 660 tatgcacacg tggcagctgc agtcctacaa atccgttcag tggaaggcag aaagaaggcc 720 ttttccacat gtggctccca cctcacagtg gtttgcctct tctatggtac tggtatcttc 780 aactacatgc gtcttggttc cgaggagtct tcagacaagg ataaaggggt tggggtcttt 840 aatactgtta tcaaccccat gctgaaccct ctcatttaca gtcttagaaa tcctgatgtt 900 cagggcgccc tgtggcgggt acttgtgggg aagcagtcac tgacttaa 948

<210> 3636 <211> 315 <212> PRT <213> Felis catus <400> 3636

Met Glu Pro Glu Val Gly Val Asn Arg Thr Ser Val Thr Glu Phe Ile 1 5 10 15 Leu Leu Gly Leu Val Glu Thr Glu Gln Leu Gln Ser Val Val Phe Val 20 25 30 Val Phe Leu Phe Ala Tyr Leu Leu Thr Val Gly Gly Asn Leu Ser Ile 35 40 45 Leu Ala Ala Ile Leu Val Glu Pro Lys Leu His Thr Pro Met Tyr Phe 50 55 60 Phe Leu Gly Asn Leu Ser Val Leu Asp Val Gly Cys Ile Thr Val Thr 65 70 75 80

Page 4072

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Val Pro Ser Met Leu Ala Arg Leu Leu Ser His Lys Arg Thr Val 95 Pro 85 90 Tyr Arg Ala Cys Leu Thr Gln Leu Phe Phe Phe His Leu Leu Ala Gly 100 105 110 Met Asp Cys Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Leu Ala 115 120 125 Ile Cys Arg Pro Leu Thr Tyr Ser Thr Gln Met Ser Lys Thr Val Gln 130 135 140 Arg Met Leu Val Val Val Ser Trp Ala Leu Gly Phe Thr Asn Ala Leu 145 150 155 160 Asn His Thr Leu Thr Leu Thr Thr Leu Asn Phe Cys Gly Pro Asn Val 165 170 175 Ile Asn His Phe Tyr Cys Asp Leu Pro Gln Leu Phe Gln Leu Ser Cys 180 185 190 Ser Ser Thr Gln Leu Asn Glu Leu Leu Leu Phe Val Ala Ala Ala Phe 195 200 205 Met Ala Val Thr Pro Leu Val Leu Ile Thr Val Ser Tyr Ala His Val 210 215 220 Ala Ala Ala Val Leu Gln Ile Arg Ser Val Glu Gly Arg Lys Lys Ala 225 230 235 240 Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Cys Leu Phe Tyr Gly 245 250 255 Thr Gly Ile Phe Asn Tyr Met Arg Leu Gly Ser Glu Glu Ser Ser Asp 260 265 270 Lys Asp Lys Gly Val Gly Val Phe Asn Thr Val Ile Asn Pro Met Leu 275 280 285

Page 4073

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Asn Pro Leu Ile Tyr Ser Leu Arg Asn Pro Asp Val Gln Gly Ala Leu 290 295 300

Trp Arg Val Leu Val Gly Lys Gln Ser Leu Thr

305 310 315 <210> 3637 <211> 907 <212> DNA <213> Felis catus <400> 3637 agtcttccca gagccccatg catgtccttg ttcctcaggc tgtagatgaa agggttcatc 60 atgggggtca ccacagcata catcactgtg gctactgagt ccttcatgga gtaagtttgg 120 agggctgcag atataccata ccaagtgtcc catagaagag ggagaccaca gccaaatgtg 180 aggcacaggt ggagaaggct ttgtacttcc cagtcactga gggtatttgg agaatagttc 240 tgacaatccg gacataggac atgatcatga atcctaaggg ggtaaggaag ataaagcagc 300 ctgtggcaat cagcaccatg tgattgactt gggtgttaga acacgcgagc ctcagcagga 360 catacatctc acagaagatg tagtggatct tccgggaacc acagaaggtc accctggtca 420 tgaggagggt gtgggtgagg ccatagagga cagaaagtgc ccaacacaag gtgaggagca 480 aaatgcagag tccaggactc atggccgtgg tgtaatggag ggggcggcag atggccacat 540 agcggtcata ggccattgtg gccaggatga ggttgtccag ggccaccaag gagacgagga 600 agtagagctg cgtcagacac cctgcatagg agatggcttt gttctgagac tgaaggctca 660 ccagcatctt ggggattgtg ttggtgacga agaagaggtc ggtgaaggag aggttggcca 720 ggaagaagta catgggagtg tgcaagcggg gatcaaagct gatggccagg atgatgagca 780 catttcccac cactgtgacc atgtacatgg acaggaacat ccagaatagg atccgctgct 840 gctcaggact ctccgagatc cccaggagca ggaactcgga gactctactc tggttgcttc 900 catgcat 907 <210> 3638 <211> 267 <212> PRT <213> Felis catus

Page 4074

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<400> 3638 Asn Gln Ser Arg Val Ser Glu Phe Leu Leu Leu 15 Gly Met 1 His Gly Ser 5 10 Ile Ser Glu Ser Pro Glu Gln Gln Arg Ile Leu Phe Trp Met Phe Leu 20 25 30 Ser Met Tyr Met Val Thr Val Val Gly Asn Val Leu Ile Ile Leu Ala 35 40 45 Ile Ser Phe Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Thr Asp Leu Phe Phe Val Thr Asn Thr Ile Pro Lys 65 70 75 80 Met Leu Val Ser Leu Gln Ser Gln Asn Lys Ala Ile Ser Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Leu Tyr Phe Leu Val Ser Leu Val Ala Leu Asp Asn 100 105 110 Leu Ile Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Thr Thr Ala Met Ser Pro Gly Leu Cys Ile Leu Leu 130 135 140 Leu Thr Leu Cys Trp Ala Leu Ser Val Leu Tyr Gly Leu Thr His Thr 145 150 155 160 Leu Leu Met Thr Arg Val Thr Phe Cys Gly Ser Arg Lys Ile His Tyr 165 170 175 Ile Phe Cys Glu Met Tyr Val Leu Leu Arg Leu Ala Cys Ser Asn Thr 180 185 190 Gln Val Asn His Met Val Leu Ile Ala Thr Gly Cys Phe Ile Phe Leu 195 200 205

Page 4075

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Thr Pro Leu Gly Phe Met Ile Met Ser Tyr Val Arg Ile Val Arg Thr 210 215 220

Ile Leu Gln Ile Pro Ser Val Thr Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240

Cys Ala Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Leu Gly 245 250 255

Met Val Tyr Leu Gln Pro Ser Lys Leu Thr Pro 260 265 <210> 3639 <211> 954 <212> DNA <213> Felis catus <400> 3639 tcactggccc aaggaaaaga agactttgcc gtccttgttc ctcaggctgt aaatgaaggg gacagcagca gccgtatcct cttctatgga agccctgatc actgtcccaa agaagagggc aaaggctttg tgccttccct gggcagaggg atacgaaacc aggatgagaa taaaggggat cacaagctca ttgacctgag tgtcagagca gaagaagtca ggaatgatct tcttagagca ggtcatggca acaagactcg taaggaccca gcggctcatg actatcttat agtggagagg cattgtggcc aggagaaaga tgtccatgtc caagcatccc gcataggaaa tggacctgct cacggtggtg gaggtgaaaa ggatgtcagc gggtgtgtga agacgtgcgt cagtgccaat cctgagacat gttcagcagg gttggaggaa aacaacagca gactctgagg caaaatgact agacactttc aaaggaaagt gcaggcagta gtggcagatg cccaaaagtc ctgggtctgg acaggacagg ggccagaacg

ctcgccaggg cacacttcat 60 ggagttatca ctgtgtacat 120 gaggatgagg ggcacagata 180 aggtgggacc cacatgtaga 240 atggctgaaa caatgtggat 300 gctcctccca agaagagcag 360 atcagaggtc ccagatcaca 420 cgaaagatga ggaaagtgtg 480 accaggaggg tgcagcgctg 540 gccacgtagc ggtcataggc 600 aagaagaagt agagctggac 660 atattcacca gggccttggg 720 ctggcgagga agaagtacat 780 atgagcaggt tcccagtcac 840

Page 4076

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954

069269_0225_SL.TXT ggtgaccaca tacatgcaca ggaacagcag gaagaggatg cgctgctgct ctggccgctc tgagagtccc cagaggagga actccaagat gctggtctgg ttccctcctg ccat <210> 3640 <211> 317 <212> PRT <213> Felis catus <400> 3640

Met 1 Ala Gly Gly Asn 5 Gln Thr Ser Ile Leu Glu Phe Leu Leu Trp Gly 10 15 Leu Ser Glu Arg Pro Glu Gln Gln Arg Ile Leu Phe Leu Leu Phe Leu 20 25 30 Cys Met Tyr Val Val Thr Val Thr Gly Asn Leu Leu Ile Val Leu Ala 35 40 45 Ile Gly Thr Asp Ala Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Ser Leu Ser Cys Ala Asp Ile Leu Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Ala Leu Val Asn Ile Gln Thr Gln Ser Arg Ser Ile Ser Tyr Ala Gly 85 90 95 Cys Leu Val Gln Leu Tyr Phe Phe Leu Thr Phe Gly Asp Met Asp Ile 100 105 110 Phe Leu Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Lys Ile Val Met Ser Arg Gln Arg Cys Thr Leu Leu 130 135 140 Val Thr Ala Cys Trp Val Leu Thr Ser Leu Val Ala Met Thr His Thr 145 150 155 160 Phe Leu Ile Phe Arg Leu Ser Phe Cys Ser Lys Lys Ile Ile Pro Asp Page 4077

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069269_0225_SL.TXT

170

Phe Phe Cys Asp Leu Gly Pro Leu Met 185 Lys Val Ser Cys Ser 190 Asp Thr 180 Gln Val Asn Glu Leu Val Leu Leu Phe Leu Gly Gly Ala Val Ile Leu 195 200 205 Ile Pro Phe Ile Leu Ile Leu Val Ser Tyr Ile His Ile Val Ser Ala 210 215 220 Ile Leu Arg Val Pro Ser Ala Gln Gly Arg His Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ala Val Val Ala Leu Phe Phe Gly Thr Val Ile 245 250 255 Arg Ala Tyr Leu Cys Pro Ser Ser Ser Ser Ser Asn Ser Ile Glu Glu 260 265 270 Asp Thr Ala Ala Ala Val Met Tyr Thr Val Ile Thr Pro Leu Leu Asn 275 280 285 Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Met Lys Cys Ala Leu Ala 290 295 300 Arg Cys Leu Arg Gly Lys Val Phe Phe Ser Leu Gly Gln 305 310 315

<210> 3641 <211> 922 <212> DNA <213> Felis catus <400> 3641 agataaccag ggaaaatttc gctcatcatc tgccaacctc

tcctttgccc ttggtttcat tctcctggga cttactggtc aacaacaaca 60 ttcttcatcc tcttcctctt catttacccc atcacattga ttggaaacct 120 ttggccattc actctgacat tcaccttcac aaccccatgt attttttcct 180 tcctttgttg acatcttatt ctcctctgta accatcccaa agatgctagc 240

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caaccatgtc ttgggcagca aagccatctc ctttggggga tgtctaacac agatgtattt 300 catgattgac atgtctaaca cagatagcta tatcctggct gtgatggcat atgatcgtgc 360 cgtggccatc agctgcccac ttcgttacac aacaattatg agcccacgga cttgtgtctt 420 gctggttgtt gggtcttggg tggttggaaa cgccaatgcc ctcccccaca ctctgctcac 480 agctagtctg tctttctgtg gcaaccagga agtagccaac ttctactgtg acactgcctc 540 tttactcaag ctgtcctgtt ctgacattca ttttaatgtg aagatgatgt acctaggggt 600 tggtattttc tctgtgccat tactatgcat catcatctcc tacatccggg tcttttccac 660 agtcttacgg gttccatcca ccaagggtgt gctcaaagcc ttctccacct gtggcttgca 720 cctcacagtt gtttctctgt attatgggac agtcatgggc atgtatttcc gccctctgac 780 tagttatagc ctgaaggacg cagtgataac tgtgatgtac attgcagtga ccccaatgct 840 aaatcctttc atctacagtc tgagaaaccg agacatgaag gctgccctgg gaaaactctt 900 cagcaaaaga ctctcctcat aa 922 <210> 3642 <211> 306 <212> PRT <213> Felis catus <400> 3642 Asp Asn Gln Ser Phe Ala Leu Gly Phe Ile Leu Leu Gly Leu Thr Gly 1 5 10 15 Gln Gln Gln Gln Glu Asn Phe Phe Phe Ile Leu Phe Leu Phe Ile Tyr 20 25 30 Pro Ile Thr Leu Ile Gly Asn Leu Leu Ile Ile Leu Ala Ile His Ser 35 40 45 Asp Ile His Leu His Asn Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser 50 55 60 Phe Val Asp Ile Leu Phe Ser Ser Val Thr Ile Pro Lys Met Leu Ala 65 70 75 80

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Asn His Val Leu Gly 85 Ser Lys Ala Ile Ser Phe Gly Gly Cys 90 Leu 95 Thr Gln Met Tyr Phe Met Ile Asp Met Ser Asn Thr Asp Ser Tyr Ile Leu 100 105 110 Ala Val Met Ala Tyr Asp Arg Ala Val Ala Ile Ser Cys Pro Leu Arg 115 120 125 Tyr Thr Thr Ile Met Ser Pro Arg Thr Cys Val Leu Leu Val Val Gly 130 135 140 Ser Trp Val Val Gly Asn Ala Asn Ala Leu Pro His Thr Leu Leu Thr 145 150 155 160 Ala Ser Leu Ser Phe Cys Gly Asn Gln Glu Val Ala Asn Phe Tyr Cys 165 170 175 Asp Thr Ala Ser Leu Leu Lys Leu Ser Cys Ser Asp Ile His Phe Asn 180 185 190 Val Lys Met Met Tyr Leu Gly Val Gly Ile Phe Ser Val Pro Leu Leu 195 200 205 Cys Ile Ile Ile Ser Tyr Ile Arg Val Phe Ser Thr Val Leu Arg Val 210 215 220 Pro Ser Thr Lys Gly Val Leu Lys Ala Phe Ser Thr Cys Gly Leu His 225 230 235 240 Leu Thr Val Val Ser Leu Tyr Tyr Gly Thr Val Met Gly Met Tyr Phe 245 250 255 Arg Pro Leu Thr Ser Tyr Ser Leu Lys Asp Ala Val Ile Thr Val Met 260 265 270 Tyr Ile Ala Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg 275 280 285

Page 4080

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Asn Arg Asp Met Lys Ala Ala Leu Gly Lys Leu Phe Ser Lys Arg Leu 290 295 300

Ser Ser 305 <210> 3643 <211> 930 <212> DNA <213> Felis catus <400> 3643

atgagggaaa acaaccagtc ctccaccctg gaattcatcc tcctgggagt tactggtcag 60 caggaacagg aagacttctt cttcatcctc ttcctgttca tttaccccat cacattgatt 120 ggaaacctgt tcatcatctt ggccattcac tctgacattc accttcacat ccccatgtac 180 tttttccttg ccaacctttc ctttgttgac atcttattct cctctgtaac catccccaag 240 atgctaacca accatctcat gcacagcaaa gccatctcct ttggaggatg cctagcacag 300 ttgtatttta tgattgcctt gggtaacaca gatagctata tcctggctgc gatggcatat 360 gatcgtgccg tggccatcag ccgcccactt cattacacaa caattatgag cccacggact 420 tgtgtcttgc tagttgttgt gtcctgggtg gttggaaatg ccaatgcctt cccgcacact 480 ctgctcacat ccagtctgtc cttctgtggc aataaagaag tagccaactt ctactgtgac 540 actatccctt tgctgaagct cgcctgttct gacatccgtt ttaatgtgaa ggtgatgtac 600 ctaggggctg gcgttttctc tgtaccctta ctattcatca tcatctccta tattcaggtc 660 ttttccacag tcctgagggt tccatccacc aagggtgtgc tcaaagcctt ctctacctgt 720 ggttcccacc tcactgttgt tactctatat tatgggacag tcatgggcat gtatttccgc 780 cctctgtcta gttacagcct aaaggatgca gtggtaactg ttatgtacat gacagtgatc 840 ccaatgttaa atcctttcat ttatagcctg agaaatcagg acatgaaggc tgccctgggg 900 aaactcttca gaaaaagact ctcctcataa 930

<210> 3644 <211> 309 <212> PRT <213> Felis catus

Page 4081

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<400> 3644 Asn Gln Ser Ser Thr Leu Glu Phe Ile Leu Leu 15 Gly Met 1 Arg Glu Asn 5 10 Val Thr Gly Gln Gln Glu Gln Glu Asp Phe Phe Phe Ile Leu Phe Leu 20 25 30 Phe Ile Tyr Pro Ile Thr Leu Ile Gly Asn Leu Phe Ile Ile Leu Ala 35 40 45 Ile His Ser Asp Ile His Leu His Ile Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Leu Phe Ser Ser Val Thr Ile Pro Lys 65 70 75 80 Met Leu Thr Asn His Leu Met His Ser Lys Ala Ile Ser Phe Gly Gly 85 90 95 Cys Leu Ala Gln Leu Tyr Phe Met Ile Ala Leu Gly Asn Thr Asp Ser 100 105 110 Tyr Ile Leu Ala Ala Met Ala Tyr Asp Arg Ala Val Ala Ile Ser Arg 115 120 125 Pro Leu His Tyr Thr Thr Ile Met Ser Pro Arg Thr Cys Val Leu Leu 130 135 140 Val Val Val Ser Trp Val Val Gly Asn Ala Asn Ala Phe Pro His Thr 145 150 155 160 Leu Leu Thr Ser Ser Leu Ser Phe Cys Gly Asn Lys Glu Val Ala Asn 165 170 175 Phe Tyr Cys Asp Thr Ile Pro Leu Leu Lys Leu Ala Cys Ser Asp Ile 180 185 190 Arg Phe Asn Val Lys Val Met Tyr Leu Gly Ala Gly Val Phe Ser Val 195 200 205

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Pro Leu Leu Phe Ile Ile Ile Ser Tyr Ile Gln Val Phe Ser Thr Val 210 215 220 Leu Arg Val Pro Ser Thr Lys Gly Val Leu Lys Ala Phe Ser Thr Cys 225 230 235 240 Gly Ser His Leu Thr Val Val Thr Leu Tyr Tyr Gly Thr Val Met Gly 245 250 255 Met Tyr Phe Arg Pro Leu Ser Ser Tyr Ser Leu Lys Asp Ala Val Val 260 265 270 Thr Val Met Tyr Met Thr Val Ile Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Gln Asp Met Lys Ala Ala Leu Gly Lys Leu Phe Arg 290 295 300 Lys Arg Leu Ser Ser

305

<210> 3645 <211> 924 <212> DNA <213> Felis catus <400> 3645 gaagacaacc aatcttctac cctggaattc attctcctgg gagttactgg tcagcaggca 60 caggaagact tcttcttcat cttcttcctg ttcatttacc ccatcacatt gactggaaac 120 ctgctcatca tcttggctat tcgctctgac attcgccttc acaatcccat gtattttttc 180 cttgccaacc tctcctccgt tgacatctta ttctcctctg taaccatccc caagatgcta 240 gccaaccatg tcttgcacag caaatccatc tcctttgggg gatgtctaac acaaatgtat 300 tttatgattg ccttgggtaa cacagatagc tatatcctgg ctgtgatggc atatgatcgt 360 gccatggcca tcagccgccc acttcattac acaacaatta tgagcccaca gacttgtgtc 420 cttctagttg ttggatcttg ggtggttgga aacgccaatg ccctccccca tactctgctc 480 acagctagtc tgtccttctg tggcaacaag gaggtagcca acttctactg tgacattacc 540

Page 4083

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cctttgctta agctgtcctg ttctgacatc cacttcaatg tgaagatgat gtacgtaggg 600 gttggtattt tctctgtgcc attactatgc atcatcatct cctatgtccg ggtcttttcc 660 acagttttat gggttccttc cactaagggc atgctcaaag ccttctccac ctgtggctcc 720 cacctcactg ttgtttctct gtattatggg acagtcatgg gcatgtattt ccgccctctg 780 actagttaca gcctaaagga tgcaatcatg actgttatgt acatggcagt gactccaatg 840 ctaaatcctt tcatttatag tctgagaaac agagacatga aggctgccct gaggatacta 900 ttcagcaaga gaatttcctc ataa 924

<210> 3646 <211> 307 <212> PRT <213> Felis catus

<400> 3646 Ser Thr Leu Glu Phe Ile Leu Leu Gly Val Thr Glu 1 Asp Asn Gln Ser 5 10 15 Gly Gln Gln Ala Gln Glu Asp Phe Phe Phe Ile Phe Phe Leu Phe Ile 20 25 30 Tyr Pro Ile Thr Leu Thr Gly Asn Leu Leu Ile Ile Leu Ala Ile Arg 35 40 45 Ser Asp Ile Arg Leu His Asn Pro Met Tyr Phe Phe Leu Ala Asn Leu 50 55 60 Ser Ser Val Asp Ile Leu Phe Ser Ser Val Thr Ile Pro Lys Met Leu 65 70 75 80 Ala Asn His Val Leu His Ser Lys Ser Ile Ser Phe Gly Gly Cys Leu 85 90 95 Thr Gln Met Tyr Phe Met Ile Ala Leu Gly Asn Thr Asp Ser Tyr Ile 100 105 110 Leu Ala Val Met Ala Tyr Asp Arg Ala Met Ala Ile Ser Arg Pro Leu 115 120 125

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His Tyr Thr 130 Thr Ile Met Ser Pro Gln Thr Cys Val Leu Leu Val Val 135 140 Gly Ser Trp Val Val Gly Asn Ala Asn Ala Leu Pro His Thr Leu Leu 145 150 155 160 Thr Ala Ser Leu Ser Phe Cys Gly Asn Lys Glu Val Ala Asn Phe Tyr 165 170 175 Cys Asp Ile Thr Pro Leu Leu Lys Leu Ser Cys Ser Asp Ile His Phe 180 185 190 Asn Val Lys Met Met Tyr Val Gly Val Gly Ile Phe Ser Val Pro Leu 195 200 205 Leu Cys Ile Ile Ile Ser Tyr Val Arg Val Phe Ser Thr Val Leu Trp 210 215 220 Val Pro Ser Thr Lys Gly Met Leu Lys Ala Phe Ser Thr Cys Gly Ser 225 230 235 240 His Leu Thr Val Val Ser Leu Tyr Tyr Gly Thr Val Met Gly Met Tyr 245 250 255 Phe Arg Pro Leu Thr Ser Tyr Ser Leu Lys Asp Ala Ile Met Thr Val 260 265 270 Met Tyr Met Ala Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu 275 280 285 Arg Asn Arg Asp Met Lys Ala Ala Leu Arg Ile Leu Phe Ser Lys Arg 290 295 300

Ile Ser Ser 305 <210> 3647 <211> 909

Page 4085

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 3647 atggatggag gcaaccagac tagaatctct gacttcctac tcctggggat ttcagagagt 60 cctgagcagc agcaagtcct gttctggatg ttcctgtcca tgtacctggt cacagttgtg 120 ggaaatgtgc tcatcatcct ggccatcagc tttgatcccc gcttgcacac tcccatgtac 180 ttcttcctgg ccaacctctc cttcaccgac cttttctttg tcaccaacac aatccccaag 240 atgttggtga accttcagtc ccagaacaaa gccatctcct atgcggggtg tctgacacag 300 ctctacttcc tggtctcctt ggtgacactg gacaatctca tcctggctac gatggcctat 360 gaccgctatg tggccatctg ccgccccctc cactatgtca cagccatgag ccctgggctc 420 tgtatcttgc tcctcacctt gtgttggtca ctttctctcc tctatggcct caccctcacc 480 ctcttcatga ccaaggtgac tttctgtggt tcccggaaga tccactacat cttctgtgag 540 atgtatgttc tcctgaggtt ggcctgttcc aacacccaga tcattcacat agtgctgatt 600 accacaggca tctttatctt cctcaccccc tttgggttca tgatgatatc ctacattcgt 660 atcgtcagaa ccatcctcca aataccttca gcctctagta aatacaaagc cttctccacc 720 tgtgcctctc atttggctgt ggtctccctc ttctatggga cgctttgtat ggtatatctg 780 cagcctctcc aatcctactc catgaaggac tcagtagcca cagtgatgta tgctgtggtg 840 acccccatga tgaacccttt catctacagc ctgaggaaca aggacatgca tggggctctg 900 ggaagactg 909 <210> 3648 <211> 303 <212> PRT <213> Felis catus

<400> 3648 Met Asp Gly Gly Asn Gln Thr Arg Ile Ser Asp Phe Leu Leu Leu Gly 1 5 10 15 Ile Ser Glu Ser Pro Glu Gln Gln Gln Val Leu Phe Trp Met Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Val Val Gly Asn Val Leu Ile Ile Leu Ala Page 408 6

069269_0225_SL.TXT 40 45

Ile Ser Phe Asp Pro Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Thr Asp Leu Phe Phe Val Thr Asn Thr Ile Pro Lys 65 70 75 80 Met Leu Val Asn Leu Gln Ser Gln Asn Lys Ala Ile Ser Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Leu Tyr Phe Leu Val Ser Leu Val Thr Leu Asp Asn 100 105 110 Leu Ile Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Val Thr Ala Met Ser Pro Gly Leu Cys Ile Leu Leu 130 135 140 Leu Thr Leu Cys Trp Ser Leu Ser Leu Leu Tyr Gly Leu Thr Leu Thr 145 150 155 160 Leu Phe Met Thr Lys Val Thr Phe Cys Gly Ser Arg Lys Ile His Tyr 165 170 175 Ile Phe Cys Glu Met Tyr Val Leu Leu Arg Leu Ala Cys Ser Asn Thr 180 185 190 Gln Ile Ile His Ile Val Leu Ile Thr Thr Gly Ile Phe Ile Phe Leu 195 200 205 Thr Pro Phe Gly Phe Met Met Ile Ser Tyr Ile Arg Ile Val Arg Thr 210 215 220 Ile Leu Gln Ile Pro Ser Ala Ser Ser Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Leu Cys

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250

Met Val Tyr Leu Gln Pro Leu Gln Ser Tyr Ser Met Lys Asp Ser 270 Val 260 265 Ala Thr Val Met Tyr Ala Val Val Thr Pro Met Met Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met His Gly Ala Leu Gly Arg Leu 290 295 300

<210> 3649 <211> 925 <212> DNA <213> Felis catus <400> 3649

tttctttttc caaaagactc ttcccagggc tcccttcatg tctctgttcc tcagactttg 60 gatgaaggga ttcagcacgg gggtgaccac agtgtacatc atggccaaga cagtctcctt 120 aacagcagaa ttattagctg atggacacaa gtagagaccg ataactgtcc catagaagag 180 agacagcaca gagaggtggg agccacaggt ggagaaggcc ttgaggacgc ccctggcaga 240 agggaccctg aggatggagg acacaatccg tgcataagac atgacgatga gtaggaatgg 300 gatgacgaga atgagccctc ccatgataaa tatcaccaac tcattgattc gagtatcaga 360 gcaggccagc ttcagcagag cagacatatc acagaaaaag cgggggatta tgttgttggc 420 acagaaggac agcttggcca tgagcagggt gtgcaacatg gcatgggcag tagtcagcac 480 ccaggaccac caccaaggag agacagaggt tggggctcat gatggtggtg tagtgcagag 540 gaaaacagat ggccacatag cgaccatagg ccatgacaac aatgaggaag ctctcaagaa 600 ctccaaaaaa caagtaacaa tacatctggg ccaggcagct ggcatagggg aggggcggga 660 cctggctctg catgttctga agcagtttgg gcattgtgac agaggagaag cagaggtcag 720 agaaggatta attgctaaga aacaaataca tgggcacgtg gaggtgggag tccaggcgaa 780 tgaggacgac gatgagaagg ttccccagga cggtggtaac atacacagcc aggaacagag 840 cacagaacag attccactgc tccggttcga tgggcaggcc cagaaggagg aactctgaga 900 cgacagtttg gttcctctct gccat 925

Page 4088

069269_0225_SL.TXT <210> 3650 <211> 153 <212> PRT <213> Felis catus <400> 3650

Met 1 Leu His Thr Leu 5 Leu Met Ala Lys Leu Ser Phe Cys Ala Asn Asn 10 15 Ile Ile Pro Arg Phe Phe Cys Asp Met Ser Ala Leu Leu Lys Leu Ala 20 25 30 Cys Ser Asp Thr Arg Ile Asn Glu Leu Val Ile Phe Ile Met Gly Gly 35 40 45 Leu Ile Leu Val Ile Pro Phe Leu Leu Ile Val Met Ser Tyr Ala Arg 50 55 60 Ile Val Ser Ser Ile Leu Arg Val Pro Ser Ala Arg Gly Val Leu Lys 65 70 75 80 Ala Phe Ser Thr Cys Gly Ser His Leu Ser Val Leu Ser Leu Phe Tyr 85 90 95 Gly Thr Val Ile Gly Leu Tyr Leu Cys Pro Ser Ala Asn Asn Ser Ala 100 105 110 Val Lys Glu Thr Val Leu Ala Met Met Tyr Thr Val Val Thr Pro Val 115 120 125 Leu Asn Pro Phe Ile Gln Ser Leu Arg Asn Arg Asp Met Lys Gly Ala 130 135 140 Leu Gly Arg Val Phe Trp Lys Lys Lys

145 150 <210> 3651 <211> 909 <212> DNA <213> Felis catus

Page 4089

069269_0225_SL.TXT <400> 3651 atgcatggag gcaaccagag tgagacctca gagttcctac tcctggggct ctcggagagt 60 cctaaagagc agctggtctt gttctggatg ttcctgtcca tgtacctggt cacagtggtg 120 ggaaatgtgc tcatcatcct ggccatcagc attgatcccc acttgcacac tcccatgtat 180 ttactcttgg ccaacctctc cctcactgac ctcttctttg tcaccaacac aatccccaac 240 acattagtga accttcagtc tcagaacaaa gccatctcct atgcagggtg tctgacacag 300 ctctacttcc tggtctcctt ggtgactctg gacaacttca tcctggccac aatggcatat 360 gaccgctatg tggccatctg ccgccccctc cactatgtca cagccatgaa ccctgggctc 420 tgtattttgc tcctcaccct gtgttgggga ctttctgtcc tctatggcct cttcctcacc 480 ctcttcatga ccaaagtgac attctgtggt tcccggaaga tccactacat cttctgtgag 540 atgtatgtgc tgctgaggct tgcatgctcc aatacccagg tcattcacac agtgcagatt 600 actacaggct gcttcatttt cttcaccccc ctagggatca tgatcatgtc ttatgtctgg 660 attgccagag ccatcctccg aataccctca gcttctagta aatacaaagc cttctccacc 720 tgtgcttcac atttggctgt ggtctccctc ttctatggga cacttggtat ggtatatctg 780 cagcccctcc aaacttactc catgaaggac tcagtagcca cagtgatgta tgctgtggtg 840 acccccatga tgaacccttt catctacagc ctgaggaaca aggacatgca tggggctctg 900 ggaagactg 909 <210> 3652 <211> 303 <212> PRT <213> Felis catus <400> 3652

Met 1 His Gly Gly Asn Gln Ser Glu Thr Ser Glu Phe Leu Leu Leu Gly 5 10 15 Leu Ser Glu Ser Pro Lys Glu Gln Leu Val Leu Phe Trp Met Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Val Val Gly Asn Val Leu Ile Ile Leu Ala 35 40 45

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Ile Ser 50 Ile Asp Pro His Leu His Thr Pro Met Tyr Leu Leu Leu Ala 55 60 Asn Leu Ser Leu Thr Asp Leu Phe Phe Val Thr Asn Thr Ile Pro Asn 65 70 75 80 Thr Leu Val Asn Leu Gln Ser Gln Asn Lys Ala Ile Ser Tyr Ala Gly 85 90 95 Cys Leu Thr Gln Leu Tyr Phe Leu Val Ser Leu Val Thr Leu Asp Asn 100 105 110 Phe Ile Leu Ala Thr Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Val Thr Ala Met Asn Pro Gly Leu Cys Ile Leu Leu 130 135 140 Leu Thr Leu Cys Trp Gly Leu Ser Val Leu Tyr Gly Leu Phe Leu Thr 145 150 155 160 Leu Phe Met Thr Lys Val Thr Phe Cys Gly Ser Arg Lys Ile His Tyr 165 170 175 Ile Phe Cys Glu Met Tyr Val Leu Leu Arg Leu Ala Cys Ser Asn Thr 180 185 190 Gln Val Ile His Thr Val Gln Ile Thr Thr Gly Cys Phe Ile Phe Phe 195 200 205 Thr Pro Leu Gly Ile Met Ile Met Ser Tyr Val Trp Ile Ala Arg Ala 210 215 220 Ile Leu Arg Ile Pro Ser Ala Ser Ser Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Leu Gly 245 250 255

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Met Val Tyr Leu Gln Pro Leu Gln Thr Tyr Ser Met Lys Asp Ser Val 260 265 270 Ala Thr Val Met Tyr Ala Val Val Thr Pro Met Met Asn Pro Phe Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met His Gly Ala Leu Gly Arg Leu 290 295 300

<210> 3653 <211> 917 <212> DNA <213> Felis catus <400> 3653 atggaaggaa gaaatcaaac tcatgttacg gaatttatcc tcttgggact ctcagaccag 60 ggggcgctgc agtcactgct cttttggctg ttcctgtcct tgtacttggt caccttcact 120 gggaacctac tcatgatcct ggccattatc acagactcct gcctccacat gcccatgtac 180 ttcttcctct ccaacctgtc cttttcagac atatgtttca cctccaccac catcccaaag 240 atgctgctga acatccagac gcagagcaga gggatctcct acaaaggttg cctcagccag 300 atgtactttt tcatgctttt tgcaggaatc gacaacctcc tcttgacagt gatggcctat 360 gaccggttcg tggccatctg tcacccattg cgctacatgg tcatcatgaa ccccaagttc 420 tgtggcatcc tgcttctggg atcctgttat tgagtgttct tgtttctctg ttacatgact 480 tactgatttt gcgactctct ttttgcgcag atctggaaat ccttcacttt ttctgtgaac 540 ttaagcaggt gatccaactt gcttgctctg ataccttcct caatgacctg gtaatgtatt 600 tgtcaagtgg acttctgggt gttgttccac tcactggcat cctctcctct tactctagaa 660 ttgtagcctc catcttgaga atttcatcag tgaaaggcaa gtataaagca ttttccacgt 720 gtgggtctca tctctcagtt gtgttcttgt tctatggtac aagccttggt gtatatttta 780 attctgctgc ttcacaaacc tccagcacag gtgccatagc ctcagtaatg tacacggtgg 840 tgatgcccat gctgaacccc ttcatctatg gtctcaggaa cagagacatc aagcaagccc 900 tgagaaagct ctttagc 917

Page 4092

069269_0225_SL.TXT <210> 3654 <211> 150 <212> PRT <213> Felis catus <400> 3654

Met Glu Gly Arg Asn Gln Thr His Val Thr Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Asp Gln Gly Ala Leu Gln Ser Leu Leu Phe Trp Leu Phe Leu 20 25 30 Ser Leu Tyr Leu Val Thr Phe Thr Gly Asn Leu Leu Met Ile Leu Ala 35 40 45 Ile Ile Thr Asp Ser Cys Leu His Met Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Phe Ser Asp Ile Cys Phe Thr Ser Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Leu Asn Ile Gln Thr Gln Ser Arg Gly Ile Ser Tyr Lys Gly 85 90 95 Cys Leu Ser Gln Met Tyr Phe Phe Met Leu Phe Ala Gly Ile Asp Asn 100 105 110 Leu Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Met Val Ile Met Asn Pro Lys Phe Cys Gly Ile Leu 130 135 140 Leu Leu Gly Ser Cys Tyr

145 150 <210> 3655 <211> 933 <212> DNA <213> Felis catus <400> 3655

Page 4093

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cttcctttta caaaccagcc ggcgcctccc tagtctcttc actgctgcct gcacctcctg 60 gttcctcagg gtgtagatca tggggttgag catgggggtc atgaccgtgt ggctgatgga 120 cacagccttg tccatggaga agggggtgaa gggccgggca tagaggtaaa tgcttggaat 180 gaaaaccata gacaccacga cgatgtgggt ggtgcaagtg gaagctgcct tcctcctcgc 240 ctgcccagag tgggacctca gcatcaccag gatgactgag taggaggtca ggaggagaaa 300 gaaccagatg acatccagca gcccactgtt ggagatcatg aggaactcca ggagggtggt 360 gtcagtgcag gcaagtctca gcacttgtgg gacatcacag tagaagttat ccaggacgtt 420 ggggccacag aaaggcaacg ggagcatcag agccagttgg gcaacggaat ggacgaatcc 480 tcctatccag ctagccacca caagtcccac acagagctgt gtattcatga tggtcacata 540 gtggaggggt cgggagatgg caacaaggcg gtcataggcc atgactgaga ggaagaagac 600 catggcgcct cccagaaagt ggaagaagaa gatctgggcc atgcagccct ggtaggagat 660 ggtcttcttc tcagagagga agtccaccag catctttggg gcagtgacag aggagaaaca 720 gaggtctaag acagccagat ttcggagcag aaagtacatg ggtgtgtgga gccgtgtgtc 780 tgaggtcacc gtgaccataa tgaggaggtt tcccatgaca gtggtggtat agacaaacag 840 gaacaccaga aacagaaaaa gctggagctc tcgagtctgt gagagtccca ggaagacaaa 900 ttctgatacc cacgtgaggt ttccttgttc cat 933

<210> 3656 <211> 311 <212> PRT <213> Felis catus

<400> 3656 Met 1 Glu Gln Gly Asn Leu Thr Trp Val Ser Glu Phe Val Phe Leu Gly 5 10 15 Leu Ser Gln Thr Arg Glu Leu Gln Leu Phe Leu Phe Leu Val Phe Leu 20 25 30 Phe Val Tyr Thr Thr Thr Val Met Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Thr Ser Asp Thr Arg Leu His Thr Pro Met Tyr Phe Leu Leu Arg Page 4094

069269_0225_SL.TXT

50 55 60

Asn 65 Leu Ala Val Leu Asp Leu Cys Phe Ser Ser Val Thr Ala Pro Lys 70 75 80 Met Leu Val Asp Phe Leu Ser Glu Lys Lys Thr Ile Ser Tyr Gln Gly 85 90 95 Cys Met Ala Gln Ile Phe Phe Phe His Phe Leu Gly Gly Ala Met Val 100 105 110 Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Leu Val Ala Ile Ser Arg 115 120 125 Pro Leu His Tyr Val Thr Ile Met Asn Thr Gln Leu Cys Val Gly Leu 130 135 140 Val Val Ala Ser Trp Ile Gly Gly Phe Val His Ser Val Ala Gln Leu 145 150 155 160 Ala Leu Met Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Asn 165 170 175 Phe Tyr Cys Asp Val Pro Gln Val Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 Thr Leu Leu Glu Phe Leu Met Ile Ser Asn Ser Gly Leu Leu Asp Val 195 200 205 Ile Trp Phe Phe Leu Leu Leu Thr Ser Tyr Ser Val Ile Leu Val Met 210 215 220 Leu Arg Ser His Ser Gly Gln Ala Arg Arg Lys Ala Ala Ser Thr Cys 225 230 235 240 Thr Thr His Ile Val Val Val Ser Met Val Phe Ile Pro Ser Ile Tyr 245 250 255 Leu Tyr Ala Arg Pro Phe Thr Pro Phe Ser Met Asp Lys Ala Val Ser

Page 4095

260

Ile Ser His 275 Thr Val Met Leu Arg 290 Asn Gln Glu Val Arg 305 Leu Val Cys Lys Arg 310

Thr

Gln

295

Lys

069269_0225_SL.TXT 265

Pro Met Leu Asn Pro Met 280 285

Ala Ala Val Lys Arg Leu 300

270

Ile Tyr Thr

Gly Arg Arg <210> 3657 <211> 942 <212> DNA <213> Felis <400> 3657 ttaagttcac catctcctgg gctgatggac gcagggaatg cttcctcgcc aaggagaagg gagggaggtg cagaacattg aacaaatccc ggtgacatag aaagaagaca gtaggagatg ggaataacag ccggcagtca gacaaatagg gaggataaac catus tccctgttac ttcctcagag acagccttgt aagatcatag tgctctgaat aaccagatga tcagtgcagg ggaccacaaa cctaaccaag tggaggggcc gtcccacctc gtcttgacct aggtctatga aaagtcactg aacaccagga tctgacaccc atatcactag tatagatcat ccatggggaa acaccacaat gggacctcaa ggaccagcat caagtctcag aaggcaaggg cagccaccac gggagatggc ccaagaggtg catgaaggaa cagccaggtt tgaccatgat acaggaattt ttgtgatatt acgcttgcct ggggttgagc gggggtgaag gatgtgggtg catcaccagg tccactgttg cacttgtggg gagcatcaaa tagccccaca tatgtagcgg aaagaagaag gtccaccagc tcggagcaga aaggaggttt ctcaaggtcc ctgtgcttcc aatctcttca atgggggtca ggccgggcat gtgcaggtag atgactgtgt gagatcatga atgtcacagt gccagctgga cagagctgag tcataagcca atctgagtca atctttggag aaatacatgg cccacaacag cgggtctgtg at

tggctgcctg 60 tgaccgtgta 120 agatatagat 180 aagctgcctt 240 aagaaatcag 300 ggaactccag 360 agaagttatc 420 caatggagtg 480 tgttcatgat 540 tcactgagag 600 tgcagccctg 660 aagtgacagt 720 gcatgtggag 780 tggtgacata 840 agaatcctaa 900 942

Page 4096

069269_0225_SL.TXT <210> 3658 <211> 311 <212> PRT <213> Felis catus

<400> 3658 Met 1 Glu Ala Gln Asn 5 Ile Thr Arg Val Ser Glu Phe Ile Leu Leu Gly 10 15 Phe Ser Gln Thr Arg Asp Leu Glu Lys Phe Leu Phe Leu Val Phe Leu 20 25 30 Phe Val Tyr Val Thr Thr Val Val Gly Asn Leu Leu Ile Met Val Thr 35 40 45 Val Thr Phe Asp Cys Arg Leu His Met Pro Met Tyr Phe Leu Leu Arg 50 55 60 Asn Leu Ala Val Ile Asp Leu Cys Tyr Ser Thr Val Thr Ser Pro Lys 65 70 75 80 Met Leu Val Asp Phe Leu His Glu Val Lys Thr Ile Ser Tyr Gln Gly 85 90 95 Cys Met Thr Gln Ile Phe Phe Phe His Leu Leu Gly Gly Gly Thr Val 100 105 110 Phe Phe Leu Ser Val Met Ala Tyr Asp Arg Tyr Ile Ala Ile Ser Arg 115 120 125 Pro Leu His Tyr Val Thr Ile Met Asn Thr Gln Leu Cys Val Gly Leu 130 135 140 Val Val Ala Ala Trp Leu Gly Gly Phe Val His Ser Ile Val Gln Leu 145 150 155 160 Ala Leu Met Leu Pro Leu Pro Phe Cys Gly Pro Asn Val Leu Asp Asn 165 170 175

Page 4097

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Phe Tyr Cys Asp Ile Pro Gln Val Leu Arg Leu Ala Cys Thr Asp Thr 180 185 190 Ser Leu Leu Glu Phe Leu Met Ile Ser Asn Ser Gly Met Leu Val Leu 195 200 205 Ile Trp Phe Leu Leu Leu Leu Ile Ser Tyr Thr Val Ile Leu Val Met 210 215 220 Leu Arg Ser His Ser Glu Gln Ala Arg Lys Lys Ala Ala Ser Thr Cys 225 230 235 240 Thr Thr His Ile Ile Val Val Ser Met Ile Phe Ile Pro Cys Ile Tyr 245 250 255 Ile Tyr Ala Arg Pro Phe Thr Pro Phe Pro Met Asp Lys Ala Val Ser 260 265 270 Ile Ser Tyr Thr Val Met Thr Pro Met Leu Asn Pro Met Ile Tyr Thr 275 280 285 Leu Arg Asn Gln Glu Met Gln Ala Ala Met Lys Arg Leu Gly Lys Arg 290 295 300 Leu Val Ile Cys Asn Arg Glu

305 310 <210> 3659 <211> 939 <212> DNA <213> Felis <400> 3659 atggagaggt ttgtccacaa ctgaccctcc aagcccatgt acaatgccca catus ccctggagtt ggctgggcat tggagaacac atttcttcct gtctgctcgt ggtcaacatg aaggattgtc gctcatcatc gggcaacctg gggtttgtgg acaagagtcc ctgtttgcca tacctcatct agctgcctgg actggacctt aggagtttgt tcttcctgac gcagtcacat agatgtgcta tccatatctc cttgttgggt cctctacctg cgagctccac cgtgtccgtg cttcacagcc

120

180

240

300

Page 4098

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tgcatgacac agcttttctt cttcatagtc ctcatcggca cggagtgcac cctcctggcc 360 tccatggcct atgaccgcta cgtggctatc tgccgcccac tccactaccc actgctcatg 420 aggccccagg tctgcctggg cttagccttg tcctcatggc ttggggggct gttggtctcg 480 gtggccaaga cgacatgcat tgccagcctt tcctactgtg gccccaatgt cctcaaccac 540 ttcttctgtg acgtctcccc tctgctcaac ctgtcctgca cccacgtggc cctgacggag 600 ctggtggact tcatctctgc cattgtcatc ttctgtggaa cactgttggt agcattggct 660 tcctactcgg ccatcgtggt ggctgtgctc cgcatgccat cagctgctgc ccagcgcaag 720 gccttttcca cctgtgcctc ccacctgatt gtggtgggca tcttctactc agcagccctc 780 ttcatttatt gtcgtcccag ccgtatcaaa tccatggacc tcaacaaggt gctatctgtc 840 atctacacag tggtcacgcc catgtgcaac cccatcatct actgcctgcg gaacaaggag 900 gtccatgtag tgcttcggaa aactctccac tggccttga 939

<210> 3660 <211> 312 <212> PRT <213> Felis catus <400> 3660

Met Glu Arg Ser Leu Glu Leu Val Asn Met Thr Arg Val Gln Glu Phe 1 5 10 15 Val Leu Leu Gly Leu Ser Thr Arg Leu Gly Ile Arg Ile Val Leu Phe 20 25 30 Ala Ile Phe Leu Thr Leu Tyr Leu Leu Thr Leu Leu Glu Asn Thr Leu 35 40 45 Ile Ile Tyr Leu Ile Cys Ser His Ile Glu Leu His Lys Pro Met Tyr 50 55 60 Phe Phe Leu Gly Asn Leu Ser Cys Leu Glu Met Cys Tyr Val Ser Val 65 70 75 80 Thr Met Pro Ser Leu Leu Val Gly Leu Trp Thr Gly Pro Phe His Ile 85 90 95

Page 4099

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Ser Phe Thr Ala 100 Cys Met Thr Gln Leu Phe Phe Phe Ile Val Leu Ile 105 110 Gly Thr Glu Cys Thr Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys Arg Pro Leu His Tyr Pro Leu Leu Met Arg Pro Gln Val 130 135 140 Cys Leu Gly Leu Ala Leu Ser Ser Trp Leu Gly Gly Leu Leu Val Ser 145 150 155 160 Val Ala Lys Thr Thr Cys Ile Ala Ser Leu Ser Tyr Cys Gly Pro Asn 165 170 175 Val Leu Asn His Phe Phe Cys Asp Val Ser Pro Leu Leu Asn Leu Ser 180 185 190 Cys Thr His Val Ala Leu Thr Glu Leu Val Asp Phe Ile Ser Ala Ile 195 200 205 Val Ile Phe Cys Gly Thr Leu Leu Val Ala Leu Ala Ser Tyr Ser Ala 210 215 220 Ile Val Val Ala Val Leu Arg Met Pro Ser Ala Ala Ala Gln Arg Lys 225 230 235 240 Ala Phe Ser Thr Cys Ala Ser His Leu Ile Val Val Gly Ile Phe Tyr 245 250 255 Ser Ala Ala Leu Phe Ile Tyr Cys Arg Pro Ser Arg Ile Lys Ser Met 260 265 270 Asp Leu Asn Lys Val Leu Ser Val Ile Tyr Thr Val Val Thr Pro Met 275 280 285 Cys Asn Pro Ile Ile Tyr Cys Leu Arg Asn Lys Glu Val His Val Val 290 295 300

Page 4100

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Leu Arg Lys Thr Leu His Trp Pro 305 310 <210> 3661 <211> 975 <212> DNA <213> Felis catus <400> 3661

atggagaggc ccctggagtt gggcaacgtg accagagtcc aggagtttgt cttgttgggt 60 ttgtccacaa ggctgggcat aaggattgtc ctgtttgcca tcttcctggc cctctacctg 120 ctgaccctcc tggagaacac gctcatcatc tacctcatct gcagtcacat cgagctccac 180 aagcccatgt atttcttcct gggcaacctg agctgcctgg agatgtgcta cgtgtccgtg 240 accgtgccca gcctgctcgt ggggctgggc tccagtccat gccatgtgcc cttcgcagcc 300 tgcatgacac agcttttttt attcatagct ctcattagta ccaagtgcac cctcctggcc 360 tccatggcct atgaccgcta cgtggccatc tgccgcccac tccactaccc actgctcatg 420 aggccccagg tctgcctggg cttagccttg tcctcatggc ttggggggct gttggtctca 480 gtggccaaga catcatgcat cgccagcctg tcctactgtg gccccaatgt cctcaaccac 540 tttttctgtg atgtctcccc tctgctcaac ctgtcctgca ctaacgtggc cctgacggag 600 ctggtggact tcatctctgc tatcgtcatc ttctgtgggt cattgctagt ggctctggcc 660 tcctatgtgg ccatcgggag ggctgtgctc cacatgccat cagccgtcac ccgctgcaga 720 gccctctcca cctgtgcctc ccacctggtg gtggtgggca tcttctatgg ggtggtcctc 780 ttcatgtatt cccgcccccg cctcatcggt tccacagacc tcaacaaggt gctgtctgtc 840 atctacacgg tggtcacgcc catgtgcagc cccatcatct actgcctgcg gaacagggag 900 gtccaggcag tgctgcagaa aaccctccac tcaccccggg tctcttcagc aacaacacac 960 tttgcccact cctga 975

<210> 3662 <211> 324 <212> PRT <213> Felis catus <400> 3662

Page 4101

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Met 1 Glu Arg Pro Leu 5 Glu Leu Gly Asn Val Thr Arg Val Gln Glu Phe 10 15 Val Leu Leu Gly Leu Ser Thr Arg Leu Gly Ile Arg Ile Val Leu Phe 20 25 30 Ala Ile Phe Leu Ala Leu Tyr Leu Leu Thr Leu Leu Glu Asn Thr Leu 35 40 45 Ile Ile Tyr Leu Ile Cys Ser His Ile Glu Leu His Lys Pro Met Tyr 50 55 60 Phe Phe Leu Gly Asn Leu Ser Cys Leu Glu Met Cys Tyr Val Ser Val 65 70 75 80 Thr Val Pro Ser Leu Leu Val Gly Leu Gly Ser Ser Pro Cys His Val 85 90 95 Pro Phe Ala Ala Cys Met Thr Gln Leu Phe Leu Phe Ile Ala Leu Ile 100 105 110 Ser Thr Lys Cys Thr Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val 115 120 125 Ala Ile Cys Arg Pro Leu His Tyr Pro Leu Leu Met Arg Pro Gln Val 130 135 140 Cys Leu Gly Leu Ala Leu Ser Ser Trp Leu Gly Gly Leu Leu Val Ser 145 150 155 160 Val Ala Lys Thr Ser Cys Ile Ala Ser Leu Ser Tyr Cys Gly Pro Asn 165 170 175 Val Leu Asn His Phe Phe Cys Asp Val Ser Pro Leu Leu Asn Leu Ser 180 185 190 Cys Thr Asn Val Ala Leu Thr Glu Leu Val Asp Phe Ile Ser Ala Ile 195 200 205

Page 4102

Val Ile 210 Phe Cys Gly Ser Leu 215 069269_0225_SL.TXT Leu Val Ala Leu Ala Ser 220 Tyr Val Ala Ile Gly Arg Ala Val Leu His Met Pro Ser Ala Val Thr Arg Cys Arg 225 230 235 240 Ala Leu Ser Thr Cys Ala Ser His Leu Val Val Val Gly Ile Phe Tyr 245 250 255 Gly Val Val Leu Phe Met Tyr Ser Arg Pro Arg Leu Ile Gly Ser Thr 260 265 270 Asp Leu Asn Lys Val Leu Ser Val Ile Tyr Thr Val Val Thr Pro Met 275 280 285 Cys Ser Pro Ile Ile Tyr Cys Leu Arg Asn Arg Glu Val Gln Ala Val 290 295 300 Leu Gln Lys Thr Leu His Ser Pro Arg Val Ser Ser Ala Thr Thr His 305 310 315 320 Phe Ala His Ser

<210> 3663 <211> 945 <212> DNA <213> Felis catus <400> 3663 tcagcttcag gactggtgta gggttctgca gaatgctgcc tggacctccc tgttccgcag gcagtagatg acgggattgc acatgggtgt gaccaccgtg tagatgacag acagcacctt gttgaggtcc atggcttcta tgcggctggg acgggcgtag atgaagagag tggctgagta gaagatgccc accaccacca ggtgggaggc gcaggtggag agggctttgc ggcgggcagc ggctgatgac atgtggagca cagccctccc gatggccaca taggaggtga tggccatgag aagggaaccc cagaggatga cgatggcaga gatgaagtcc accagctccg tcagggccac gtgggtgcag gacaggttga gcagagggga gacgtcacag aagaagtggt tgaggacatt

120

180

240

300

360

420

Page 4103

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ggggccacag taggaaaggc tggcaatgca tgtcgtcttg gccaccgaga ccaacagccc 480 cccaagccat gaggacaagg ctaagcccag gcagacctgg ggcctcatga gcagtgggta 540 atggagtggg cggcagatgg ccacgtagcg gtcataagcc atggaggcca agagggtgca 600 ctctgtgcag atgaggacta tgaagaagaa aagctgtgtc atgcaggctg tgaaggaaat 660 atggtaaggt ccagtccaca gccccacgag cagactgggc atggtcacgg acacgtagta 720 catctccagg cagctcaggt tgcccaggaa gaaatacatg ggcttgtgga gctcgatgtg 780 actgcagatg aggtagatga tgagcgtgtt ctccaggagg gtcagcaggt agagggtcag 840 gaagatggca aacagaacat cccttacgtc tggccttgtg gacaaaccca acaagacaaa 900 ctcctggact ctggtcacat tgcccaactc caagggcctc tccat 945

<210> 3664 <211> 312 <212> PRT <213> Felis catus

<400> 3664 Glu Leu Gly Asn Val Thr Arg Val Gln Glu Phe Met Glu 1 Arg Pro Leu 5 10 15 Val Leu Leu Gly Leu Ser Thr Arg Pro Asp Val Arg Asp Val Leu Phe 20 25 30 Ala Ile Phe Leu Thr Leu Tyr Leu Leu Thr Leu Leu Glu Asn Thr Leu 35 40 45 Ile Ile Tyr Leu Ile Cys Ser His Ile Glu Leu His Lys Pro Met Tyr 50 55 60 Phe Phe Leu Gly Asn Leu Ser Cys Leu Glu Met Tyr Tyr Val Ser Val 65 70 75 80 Thr Met Pro Ser Leu Leu Val Gly Leu Trp Thr Gly Pro Tyr His Ile 85 90 95 Ser Phe Thr Ala Cys Met Thr Gln Leu Phe Phe Phe Ile Val Leu Ile 100 105 110

Page 4104

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Cys Thr Glu 115 Cys Thr Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Val 120 125 Ala Ile Cys Arg Pro Leu His Tyr Pro Leu Leu Met Arg Pro Gln Val 130 135 140 Cys Leu Gly Leu Ala Leu Ser Ser Trp Leu Gly Gly Leu Leu Val Ser 145 150 155 160 Val Ala Lys Thr Thr Cys Ile Ala Ser Leu Ser Tyr Cys Gly Pro Asn 165 170 175 Val Leu Asn His Phe Phe Cys Asp Val Ser Pro Leu Leu Asn Leu Ser 180 185 190 Cys Thr His Val Ala Leu Thr Glu Leu Val Asp Phe Ile Ser Ala Ile 195 200 205 Val Ile Leu Trp Gly Ser Leu Leu Met Ala Ile Thr Ser Tyr Val Ala 210 215 220 Ile Gly Arg Ala Val Leu His Met Ser Ser Ala Ala Ala Arg Arg Lys 225 230 235 240 Ala Leu Ser Thr Cys Ala Ser His Leu Val Val Val Gly Ile Phe Tyr 245 250 255 Ser Ala Thr Leu Phe Ile Tyr Ala Arg Pro Ser Arg Ile Glu Ala Met 260 265 270 Asp Leu Asn Lys Val Leu Ser Val Ile Tyr Thr Val Val Thr Pro Met 275 280 285 Cys Asn Pro Val Ile Tyr Cys Leu Arg Asn Arg Glu Val Gln Ala Ala 290 295 300 Phe Cys Arg Thr Leu His Gln Ser

305 310

Page 4105

069269_0225_SL.TXT <210> 3665 <211> 939 <212> DNA <213> Felis catus <400> 3665

tcagccgaat tctcttccct ttccccggag cctcctcagt gccgccttta cctccttgtt 60 tctcagagtg tagatgagag ggttcaccat tggcgtgacc acagagtaga agagggaaat 120 gaatttgcct tggccctggt ggctggtctt agccggaagg aggtacccgt agatagctga 180 cccatagaag aggagcacca ccaccagatg ggaaaggcaa gtattaaagg cctttctctg 240 tccctcagct gagcggatct tcagcactgc ccgagctatg gagcagtagg agatcaggat 300 gatgctcagc gggacggcag tgaagaaggt gcagacacca ttgagcacgg cctcgttgag 360 acttgtgtct ccacaggcca gtttgatcat ggcaggcacc tcacacagga agttgtccac 420 cctccggtgc ccacacaatg ggagctggag agtgaacgtt gactggatca tggagttgct 480 caagccgccc agccatgcaa tggcagccag cagccggcag agccgagggc tcacgatgac 540 ggtgtagcgc aggggctggc aaactgccac atggcggtcg aatgccatca ccacgagcag 600 gatgcactca gtggccccta gccagaggaa aacatagagc tggatcacac agccagcgta 660 gcttatagtc ttatctggtc cccataagtt ggtcagcatt tgggggaccg agctggtagt 720 aaaagcgagg tccagggagg agaggttgct gaggaagaag tacatggggg tgtggagccg 780 ggcatccagg caggagagca ggatggtggt cgaattccca actagggtca gcgagtaaga 840 gaagagaatg actatgaaaa agacgatctc cagctgggga tggtcagata tacccatcag 900 gatgaagccc tctgaaaagc tgttgttggc ctctgccat 939

<210> 3666 <211> 312 <212> PRT <213> Felis catus <400> 3666

Met Ala Glu Ala Asn Asn Ser Phe Ser Glu Gly Phe Ile Leu Met Gly 1 5 10 15 Ile Ser Asp His Pro Gln Leu Glu Ile Val Phe Phe Ile Val Ile Leu

20 25 30

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Phe Ser Tyr 35 Ser Leu Thr Leu Val Gly Asn Ser Thr Thr Ile Leu Leu 40 45 Ser Cys Leu Asp Ala Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Ser Leu Asp Leu Ala Phe Thr Thr Ser Ser Val Pro Gln 65 70 75 80 Met Leu Thr Asn Leu Trp Gly Pro Asp Lys Thr Ile Ser Tyr Ala Gly 85 90 95 Cys Val Ile Gln Leu Tyr Val Phe Leu Trp Leu Gly Ala Thr Glu Cys 100 105 110 Ile Leu Leu Val Val Met Ala Phe Asp Arg His Val Ala Val Cys Gln 115 120 125 Pro Leu Arg Tyr Thr Val Ile Val Ser Pro Arg Leu Cys Arg Leu Leu 130 135 140 Ala Ala Ile Ala Trp Leu Gly Gly Leu Ser Asn Ser Met Ile Gln Ser 145 150 155 160 Thr Phe Thr Leu Gln Leu Pro Leu Cys Gly His Arg Arg Val Asp Asn 165 170 175 Phe Leu Cys Glu Val Pro Ala Met Ile Lys Leu Ala Cys Gly Asp Thr 180 185 190 Ser Leu Asn Glu Ala Val Leu Asn Gly Val Cys Thr Phe Phe Thr Ala 195 200 205 Val Pro Leu Ser Ile Ile Leu Ile Ser Tyr Cys Ser Ile Ala Arg Ala 210 215 220 Val Leu Lys Ile Arg Ser Ala Glu Gly Gln Arg Lys Ala Phe Asn Thr 225 230 235 240

Page 4107

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Cys Leu Ser His Leu Val Val Val Leu Leu Phe Tyr Gly Ser Ala Ile 245 250 255 Tyr Gly Tyr Leu Leu Pro Ala Lys Thr Ser His Gln Gly Gln Gly Lys 260 265 270 Phe Ile Ser Leu Phe Tyr Ser Val Val Thr Pro Met Val Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Glu Val Lys Ala Ala Leu Arg Arg Leu 290 295 300 Arg Gly Lys Gly Arg Glu Phe Gly

305 310 <210> 3667 <211> 939 <212> DNA <213> Felis catus <400> 3667

accaggtaga aaaatattca gagcaaccac ttttccaaga gcccctttta tgtccttgtt 60 cctcaggctg tagatgaagg ggttcaacat gggggtcacc accgtgaaca tcacagcaga 120 tgctatatct gcctcagctg agtgtgaggc taaagggttg aaatacacag caatgatggt 180 gccatagaag agggaaacca cggccaggtg cgagccacag gtggagaagg ctttccatct 240 tcccttcgtg gacgggactc tcaggacagc gcgggtaata tggacatacg aagccaggat 300 gcaaataaat ggagagatca tgatcaaccc tgcttcaata agaaccatca tctcattgag 360 atgggtgtca gagcaggaca gtttcaggag gggagtcaca tcacagaaga agtgggggat 420 ggcattgtct gcacagaacg agagtcgagc catcagcagg gtatgcagta ggacatccag 480 gttggcaatg acccatgacc caacaaccag cagggcacag agctggtggg tcatctttgt 540 cgagtagtgt aaggggtggc atatggcaac aaagcggtca taggccatca cagccaggag 600 gaaattgtcc atgtccacga acatgaacac aaaatacatc tgtgtgagac acccagagaa 660 ggagatggcc tgagtcccaa ggatgtggtt ggccagcatc ttggggacgg tggtggtgga 720

Page 4108

069269_0225_SL.TXT gaagcagatg tccacaaagg acaggtggct gaggaggaag tacatgggga tgtgcaggcg 780 ggggtccacg cagatggcca ggaggatgag caggtttccc aggaccgtgg ccaggtacat 840 gctcaggaag agcgcaaaga gggcctgctg ctgctggggc tgcctggaga gcccgaggag 900 gaggaactcg gagacactcg actggtttgc tcctctcat 939 <210> 3668 <211> 313 <212> PRT <213> Felis catus

<400> 3668 Ala Asn 5 Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly Met 1 Arg Gly 10 15 Leu Ser Arg Gln Pro Gln Gln Gln Gln Ala Leu Phe Ala Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ala Thr Val Leu Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 Ile Cys Val Asp Pro Arg Leu His Ile Pro Met Tyr Phe Leu Leu Ser 50 55 60 His Leu Ser Phe Val Asp Ile Cys Phe Ser Thr Thr Thr Val Pro Lys 65 70 75 80 Met Leu Ala Asn His Ile Leu Gly Thr Gln Ala Ile Ser Phe Ser Gly 85 90 95 Cys Leu Thr Gln Met Tyr Phe Val Phe Met Phe Val Asp Met Asp Asn 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Ser Thr Lys Met Thr His Gln Leu Cys Ala Leu Leu 130 135 140

Val Val Gly

Ser Trp Val Ile Ala

Asn Leu

Asp Val

Leu Leu His Thr

Page 4109

0 6926 9_02 25_S L.TX T 145 150 155 160 Leu Leu Met Ala Arg Leu Ser Phe Cys Ala Asp Asn Ala Ile Pro His 165 170 175 Phe Phe Cys Asp Val Thr Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190 His Leu Asn Glu Met Met Val Leu Ile Glu Ala Gly Leu Ile Met Ile 195 200 205 Ser Pro Phe Ile Cys Ile Leu Ala Ser Tyr Val His Ile Thr Arg Ala 210 215 220 Val Leu Arg Val Pro Ser Thr Lys Gly Arg Trp Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Ala Val Tyr Phe Asn Pro Leu Ala Ser His Ser Ala Glu Ala Asp Ile 260 265 270 Ala Ser Ala Val Met Phe Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Gly Ala Leu Gly Lys Val 290 295 300 Val Ala Leu Asn Ile Phe Leu Pro Gly

305 310 <210> 3669 <211> 978 <212> DNA <213> Felis catus <400> 3669 ttagctgacc tcggcccgga cgacgttccc tgacgtcctg ccgccgacca cccgccacag ggcaccctgc acgtcccggt tgcgcagcgt gtagatggca gggtagagca acggcgtgag

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gttgatgtag acgagcgaca ccagcttgtc ctcctcgagg gagcggctgc tcaggggtcg 180 ggcgtacatg gccgtggcac agccatagtg gagcacggcc acggtgagat gcgacgccac 240 cgtgttgaag gccttgcggc ggcccgccac ccccccgact cccaggatga ccgccagcac 300 cctggtgtag gacagcagga tcaggaccag aggcagcacc agcagcagca ggcaggcggc 360 cagcaggacc ctctcctgca ggtcccggtc cccacaggcc agcaccaaca cggccgggag 420 gtcacagaag acgtggttga cgaggccccc ccggcagaag ggcagctgga agatggccac 480 ggtgaggccc aaggccagga gagagccccc aacgcagcag gaggcgagaa ggcaccggca 540 gcgccccgcg gtcatgagcc gggggtagca gagagggcgg cagatggcca ggtagcggtc 600 cagtgccatg gcggccagca gcaggcactc ggagcctccc agcgccacga agaggcccat 660 ctgggcagca caggtggagc gggccaccgc ctggcccccc gggggcagca ggaagcccgc 720 gagcatgcgc ggagtcagca ccagcgtgta ggccacctcc acggccgaca gcgcccccag 780 aaagaagtac atgggggtgt gcagggcggg gtccccgacg gccaggccca ggatgagcag 840 gtttcccacc agcgtggcca ggtagagtgg cagcaggaag gcaaagagca gcagccgcag 900 cccccggggc cacccggaga aacccaggat cacgaactcc cgcggagccg tccggtttga 960 cccaggccag gggctcat 978

<210> 3670 <211> 325 <212> PRT <213> Felis catus <400> 3670

Met 1 Ser Pro Trp Pro Gly Ser Asn Arg Thr Ala Pro Arg Glu Phe Val 5 10 15 Ile Leu Gly Phe Ser Gly Trp Pro Arg Gly Leu Arg Leu Leu Leu Phe 20 25 30 Ala Phe Leu Leu Pro Leu Tyr Leu Ala Thr Leu Val Gly Asn Leu Leu 35 40 45 Ile Leu Gly Leu Ala Val Gly Asp Pro Ala Leu His Thr Pro Met Tyr

50 55 60

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Phe 65 Phe Leu Gly Ala Leu Ser Ala Val Glu Val Ala Tyr Thr Leu Val 70 75 80 Leu Thr Pro Arg Met Leu Ala Gly Phe Leu Leu Pro Pro Gly Gly Gln 85 90 95 Ala Val Ala Arg Ser Thr Cys Ala Ala Gln Met Gly Leu Phe Val Ala 100 105 110 Leu Gly Gly Ser Glu Cys Leu Leu Leu Ala Ala Met Ala Leu Asp Arg 115 120 125 Tyr Leu Ala Ile Cys Arg Pro Leu Cys Tyr Pro Arg Leu Met Thr Ala 130 135 140 Gly Arg Cys Arg Cys Leu Leu Ala Ser Cys Cys Val Gly Gly Ser Leu 145 150 155 160 Leu Ala Leu Gly Leu Thr Val Ala Ile Phe Gln Leu Pro Phe Cys Arg 165 170 175 Gly Gly Leu Val Asn His Val Phe Cys Asp Leu Pro Ala Val Leu Val 180 185 190 Leu Ala Cys Gly Asp Arg Asp Leu Gln Glu Arg Val Leu Leu Ala Ala 195 200 205 Cys Leu Leu Leu Leu Val Leu Pro Leu Val Leu Ile Leu Leu Ser Tyr 210 215 220 Thr Arg Val Leu Ala Val Ile Leu Gly Val Gly Gly Val Ala Gly Arg 225 230 235 240 Arg Lys Ala Phe Asn Thr Val Ala Ser His Leu Thr Val Ala Val Leu 245 250 255 His Tyr Gly Cys Ala Thr Ala Met Tyr Ala Arg Pro Leu Ser Ser Arg 260 265 270

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Ser Leu Glu Glu Asp Lys Leu Val Ser Leu Val Tyr Ile Asn Leu Thr 275 280 285

Pro Leu Leu Tyr Pro Ala Ile Tyr Thr Leu Arg Asn Arg Asp Val Gln 290 295 300

Gly Ala Leu Trp Arg Val Val Gly Gly Arg Thr Ser Gly Asn Val Val 305 310 315 320

Arg Ala Glu Val Ser 325 <210> 3671 <211> 945 <212> DNA <213> Felis catus <400> 3671 tcacagccca caggataaag cctttatact cttgtttctc aggcagtaaa tgaaggggtt tgaagccagt gaatccttgt cagttgaatg gatagtccca tagaagaggg tgactacagc ttgtttgccc tgggtagatg ggaccttaag aagaatggcg aggaaaggaa tgaggacaat gttgagctgt gtattggaac aggatagctg agggatgacg ttgctggcac agaactccag gtggaggctg gcgatgagcc aggagctccc catggtggaa tagtgaaggg ggtggcagat caggagaaag ttgtccatgt tggcaagcaa acaataagaa atggactgag tctgcatctg ggagatgaag cagaaatcca caagggaaag gaggtgggag tctgaaccaa tggccaggat gaacagtttt cagcatgggt ggatgatgag aagatgagaa cacagcagac caaacccccc gagcagggga ccgagccatg cagcatcagg ggccacataa aatgcagaag gatgttcaca gttgctgagg ggtgagcaag

cttgtggctc ccttcatgtc 60 gtgaccacca tatacatcac 120 ggactcaagt agacccccgt 180 ccacaggtag aaaaggcctt 240 acaatgtggg tgtaggacac 300 accagcagaa tcatgagctg 360 atgaggtcac aaaagaagta 420 aggatagtgt gtagcaggga 480 gcacagattt gcagactcat 540 cggtcataag ccattgccat 600 tagatctggg ttaggcagcc 660 agcatcttag ggactgtgga 720 aagaagtata tgggtgtgtg 780 ttccctgctg ccccgaccag 840

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900

945

069269_0225_SL.TXT gtacatgaca aggaagagcc caaagatcag atcttgcctt tcgggctggc tggagagccc taggaggatg aactcagagg cactcgtgta gttttcttcc tccat <210> 3672 <211> 314 <212> PRT <213> Felis catus <400> 3672

Met Glu Glu Glu Asn Tyr Thr Ser Ala Ser Glu Phe Ile Leu Leu Gly 1 5 10 15 Leu Ser Ser Gln Pro Glu Arg Gln Asp Leu Ile Phe Gly Leu Phe Leu 20 25 30 Val Met Tyr Leu Val Gly Ala Ala Gly Asn Leu Leu Thr Ile Leu Ala 35 40 45 Ile Gly Ser Asp Ser His Leu His Thr Pro Ile Tyr Phe Phe Leu Ser 50 55 60 Asn Leu Ser Leu Val Asp Phe Cys Phe Ile Ser Ser Thr Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Met Gln Thr Gln Ser Ile Ser Tyr Cys Gly 85 90 95 Cys Leu Thr Gln Ile Tyr Phe Cys Ile Leu Leu Ala Asn Met Asp Asn 100 105 110 Phe Leu Leu Met Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Ser Thr Met Met Ser Leu Gln Ile Cys Ala Leu Met 130 135 140 Leu Gly Ser Ser Trp Leu Ile Ala Ser Leu His Ser Leu Leu His Thr 145 150 155 160 Ile Leu Met Ala Arg Leu Glu Phe Cys Ala Ser Asn Val Ile Pro Tyr

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165 170 175

Phe Phe Cys Asp Leu Ile Pro Leu Leu Gln Leu Ser Cys Ser Asn Thr 180 185 190 Gln Leu Asn Gln Leu Met Ile Leu Leu Val Gly Gly Leu Ile Val Leu 195 200 205 Ile Pro Phe Leu Ala Ile Leu Val Ser Tyr Thr His Ile Val Ser Ala 210 215 220 Val Leu Lys Val Pro Ser Thr Gln Gly Lys Gln Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ala Val Val Thr Leu Phe Tyr Gly Thr Ile Thr 245 250 255 Gly Val Tyr Leu Ser Pro Ser Ser Ser His Ser Thr Asp Lys Asp Ser 260 265 270 Leu Ala Ser Val Met Tyr Met Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Cys Leu Arg Asn Lys Asp Met Lys Gly Ala Thr Arg Lys Leu 290 295 300 Phe Ser Ile Lys Ala Leu Ser Cys Gly Leu 305 310

<210> 3673 <211> 949 <212> DNA <213> Felis catus <400> 3673 gcaattgcca tctctgagtg agaatctccc tccccatcac tcctctcaga gccttggcta catccttatt ccggagagta taaatcaaag gattcagggt aggagtaatg atgctataga acacagaacc aactttgtct tgcagtggag ttctctggga tccgggcctc atatatgaga agatgcaggc accaaaccaa aaggaaacca caatgaggtg agagctacaa gtggcaaaag Page 4115

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180

240

069269_0225_SL.TXT

catttctctt actcccagct gaacgcatct gaatgacact gtggagaatg aaggcatacg 300 atgtagaaat gaagagggtg gggaggagga gaagtacaat gctgatgatg tacactatgg 360 tctcatatac agtgatgtct ccacacacca acttcaaaat agctggaaac tcacaataga 420 agtggtggat ttttcgagac ccacagaaag gtaagtgcat caagatcact gtgtgaatta 480 gagagtttat ggatgctccc aaccacgaca tgaccaccat catcagtccc acctttctgc 540 tcatgagaac agtatagcga agtggatgac agatggcaac atagcggtca taagacatga 600 gagctaagag aagacactca gcaccaccca gagacaaata caggaagtgc tgggttgcac 660 agcccacaaa ggagatggtc ttcttgccag ataggtagtt ggtagccatc ttggggatgg 720 ttgtggagac atgcatcaga tccatgaggg agagctggct gagcaggaag tacatgggtg 780 tatgaagccg agcatcagca cagatgagga gaatagtgag catgttgcca ctcaccgcaa 840 taaggaagac cactatggtt aaagagaaaa ggaaaagatg ggtgagagag tcatcaaaga 900 gcccttcaag gatgaagtct gccagagagg tctgattcct ctgccacat 949

<210> 3674 <211> 317 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (317)..(317) <223> Any amino acid

<400> 3674 Gln Thr Ser Leu Ala Asp Phe Ile Leu Glu Gly Met 1 Trp Gln Arg Asn 5 10 15 Leu Phe Asp Asp Ser Leu Thr His Leu Phe Leu Phe Ser Leu Thr Ile 20 25 30 Val Val Phe Leu Ile Ala Val Ser Gly Asn Met Leu Thr Ile Leu Leu 35 40 45 Ile Cys Ala Asp Ala Arg Leu His Thr Pro Met Tyr Phe Leu Leu Ser 50 55 60

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Gln 65 Leu Ser Leu Met Asp Leu Met His Val Ser Thr Thr Ile Pro Lys 70 75 80 Met Ala Thr Asn Tyr Leu Ser Gly Lys Lys Thr Ile Ser Phe Val Gly 85 90 95 Cys Ala Thr Gln His Phe Leu Tyr Leu Ser Leu Gly Gly Ala Glu Cys 100 105 110 Leu Leu Leu Ala Leu Met Ser Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Arg Tyr Thr Val Leu Met Ser Arg Lys Val Gly Leu Met Met 130 135 140 Val Val Met Ser Trp Leu Gly Ala Ser Ile Asn Ser Leu Ile His Thr 145 150 155 160 Val Ile Leu Met His Leu Pro Phe Cys Gly Ser Arg Lys Ile His His 165 170 175 Phe Tyr Cys Glu Phe Pro Ala Ile Leu Lys Leu Val Cys Gly Asp Ile 180 185 190 Thr Val Tyr Glu Thr Ile Val Tyr Ile Ile Ser Ile Val Leu Leu Leu 195 200 205 Leu Pro Thr Leu Phe Ile Ser Thr Ser Tyr Ala Phe Ile Leu His Ser 210 215 220 Val Ile Gln Met Arg Ser Ala Gly Ser Lys Arg Asn Ala Phe Ala Thr 225 230 235 240 Cys Ser Ser His Leu Ile Val Val Ser Phe Trp Phe Gly Ala Cys Ile 245 250 255 Phe Ser Tyr Met Arg Pro Gly Ser Gln Arg Thr Pro Leu Gln Asp Lys 260 265 270

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Val Gly Ser Val Phe Tyr Ser Ile Ile Thr Pro Thr Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Asp Val Ala Lys Ala Leu Arg Gly Val 290 295 300 Met Gly Arg Glu Ile Leu Thr Gln Arg Trp Gln Leu Xaa 305 310 315

<210> 3675 <211> 852 <212> DNA <213> Felis catus <400> 3675 acaacagggc tcaacaaagg agtgatgatg gtataagtca ctgagagaag gtctttttct 60 attgagttct ctgacttggg cttgcggtag atgatggagg tgcagccgta gtggacgatg 120 accatcgtga ggtgggaggt gcaggtggca aaggccttct tccggccccg ggcggagggg 180 atcttgaggc tggtggagac gaggaggacg taggtgatga agttcaagct catggggacc 240 aggatcacag aggaactgac accataattg ttggtctcaa tgacagtggt gtcattacgg 300 gagagtttta gaacagggag gatgtcacag aagaaatgtc cgaccacact gacaggaggg 360 taaggtaaac acggatgtca cctggacggc caccacggcc aggccaaggc cgaaggctcc 420 gcacatcagg tgcacataca ccctcatgct catgatgact gtgtacctca gggttgcaga 480 tggccacacg gcggtcatag cccgtgaccg tgagcagaaa tcagctggct aaggcaacaa 540 agaacagcca tctgggcggc acagcctgcc gaggagttgg gctgattctg ggctaggaga 600 ccagccggca tccgtggcct ggtgaccagt gtgtatgtgg cctctgaact ccccagcatg 660 ttcaggaaga agtacacggg tgttatgggg gtgacggcta atgcagacga ccgtcacgat 720 gatggcattg ccagctgggg ttaatgtgta caggatgaga aagaccacga acagagtggg 780 ctgatgctcc tggaatctgg agaatcccag gaaaacgaac tcagtcactt ctgcgacgtt 840 ctttctctgc at 852 <210> 3676

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069269_0225_SL.TXT <211> 107 <212> PRT <213> Felis catus

<400> 3676 Val Ala Glu Val Thr Glu Phe Val Phe Leu Gly Met Gln 1 Arg Lys Asn 5 10 15 Phe Ser Arg Phe Gln Glu His Gln Pro Thr Leu Phe Val Val Phe Leu 20 25 30 Ile Leu Tyr Thr Leu Thr Pro Ala Gly Asn Ala Ile Ile Val Thr Val 35 40 45 Val Cys Ile Ser Arg His Pro His Asn Thr Arg Val Leu Leu Pro Glu 50 55 60 His Ala Gly Glu Phe Arg Gly His Ile His Thr Gly His Gln Ala Thr 65 70 75 80 Asp Ala Gly Trp Ser Pro Ser Pro Glu Ser Ala Gln Leu Leu Gly Arg 85 90 95 Leu Cys Arg Pro Asp Gly Cys Ser Leu Leu Pro 100 105

<210> 3677 <211> 972 <212> DNA <213> Felis catus <400> 3677

atgcagagaa agaacctcac agaagtgaca gaattcatct tcctgggatt ctctgtcttt 60 ggaaagcacc agataaccct ctttgtggtt ttcctaacca tctacatttt aactctagct 120 ggtgacatcg tcattgtgac catcatccgt gttgaccatc atctccgcac tcccatgtac 180 ttcttcctga gcatgctggc gagttctgag gctgcgtaca cactggtcat tgtcccacga 240 atgcttttca gtctcattct tcataaccag cctatctcct tggaaggctg tgcaactccg 300 atgttctttt ttgtcacctt ggctgtaaat agtggcttct tgctcacagc aatgggctat 360 gaccgctatg tggctatctg cagccctctg aggtacactg tcgtcatgag taaaggaatg 420

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tgtgccgggt tggtatgtgg gtcctttggc actggtctgg taatggcagt tctccacgta 480 gcagccatgt tccacttgtc cttctgtggc acagtggtgg accatttctt ctgtgacatt 540 taccctgtca tgaagctttc ttgcactgat tccactatca atgagatgat cagttatggt 600 gtcagttcct ctgtgatcct ggtccccgtg ggcttgaact tcatcaccta catcctcctt 660 gtctccacca gcctcaagat cccctccacc cggggccgga agaaggcctt tgccacctgc 720 acctcccacc tcacggtggt catcgtccac tacggctgca cctccatcat ctaccgcaag 780 cccaagtcag agaactcaat agaaaaagac cttctctcag tgacttatac catcatcact 840 cctttgttga gccctgttgt tgaaccctgt tgtttacagc ctgaggaaca gggaggtcag 900 ggatgctcta cgtagagccg tgggcaaaaa cacttcttaa cagatcgaat cattttgtca 960 ggagaccttt ag 972

<210> 3678 <211> 304 <212> PRT <213> Felis catus <400> 3678

Met Gln Arg Lys Asn Leu Thr Glu Val Thr Glu Phe Ile Phe Leu Gly 1 5 10 15 Phe Ser Val Phe Gly Lys His Gln Ile Thr Leu Phe Val Val Phe Leu 20 25 30 Thr Ile Tyr Ile Leu Thr Leu Ala Gly Asp Ile Val Ile Val Thr Ile 35 40 45 Ile Arg Val Asp His His Leu Arg Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Met Leu Ala Ser Ser Glu Ala Ala Tyr Thr Leu Val Ile Val Pro Arg 65 70 75 80 Met Leu Phe Ser Leu Ile Leu His Asn Gln Pro Ile Ser Leu Glu Gly 85 90 95

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Cys Ala Thr Pro 100 Met Phe Phe Phe Val Thr Leu Ala Val Asn Ser Gly 105 110 Phe Leu Leu Thr Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Ser 115 120 125 Pro Leu Arg Tyr Thr Val Val Met Ser Lys Gly Met Cys Ala Gly Leu 130 135 140 Val Cys Gly Ser Phe Gly Thr Gly Leu Val Met Ala Val Leu His Val 145 150 155 160 Ala Ala Met Phe His Leu Ser Phe Cys Gly Thr Val Val Asp His Phe 165 170 175 Phe Cys Asp Ile Tyr Pro Val Met Lys Leu Ser Cys Thr Asp Ser Thr 180 185 190 Ile Asn Glu Met Ile Ser Tyr Gly Val Ser Ser Ser Val Ile Leu Val 195 200 205 Pro Val Gly Leu Asn Phe Ile Thr Tyr Ile Leu Leu Val Ser Thr Ser 210 215 220 Leu Lys Ile Pro Ser Thr Arg Gly Arg Lys Lys Ala Phe Ala Thr Cys 225 230 235 240 Thr Ser His Leu Thr Val Val Ile Val His Tyr Gly Cys Thr Ser Ile 245 250 255 Ile Tyr Arg Lys Pro Lys Ser Glu Asn Ser Ile Glu Lys Asp Leu Leu 260 265 270 Ser Val Thr Tyr Thr Ile Ile Thr Pro Leu Leu Ser Pro Val Val Glu 275 280 285 Pro Cys Cys Leu Gln Pro Glu Glu Gln Gly Gly Gln Gly Cys Ser Thr 290 295 300

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069269_0225_SL.TXT <210> 3679 <211> 914 <212> DNA <213> Felis catus <400> 3679 ggaaagcttc ctgccagcgg cccggagcag agcatccttg acctccttgt tcctcagggt 60 gtacaccacc gggttcagca ggggggtgat gacggtgtag gtcaccgaga tcagctggtc 120 ctgatccctg gtgttctccg acttgggctt gaggtaggcg acggaggcac agccgtagtg 180 gacgacgacc accgtgaggt gagaggcgca ggtggcaaag gccttcttcc ggccccgggc 240 cgaggggatc ttgaggacgg tggagacgat gaggacgtag gagatgaaga ccaggcccat 300 ggggaccacg agcaccagca cgctgatgat cacggtcagg gtctcgttga ccgaggtgtc 360 gacgcaggag agcttcatta cgggtcggat gtcacagaag aagtgggcca ccttcgtagc 420 acagaaaggc aacctgaaca cagatgtcac ttgcgtcgtc gccacgatca gcccaatgcc 480 gcaggcgccc cccaccagct ggacacaccc tctcttgttc atgatgaccg agtatctcag 540 ggggttgcag atggccacgt agcggtcgta ccccatcgcc gtgagcagga agcagttagt 600 gatgccaaag gttacgaaaa agaacatctg ggtggcacag cctgcccgtg agatggaccg 660 gttcgtacct acaagactgg agagcatcct tgggagaatg acgagtgtat atacggtctc 720 tgaggaggac agcatgctca ggaagaagta catgggcgtg tgcaggtgag ggtccgttcg 780 gatgatggtc acaatgaccg cgttgccggc cagggtcacg acgtacagtg caaggaacac 840 gacaaacagg ccgagctggt gctcgcggaa gctggagaaa ccctggaaga cgaactcagt 900 tatgagagtg tggt 914 <210> 3680 <211> 304 <212> PRT <213> Felis catus <400> 3680

His Thr Leu Ile Thr Glu Phe Val Phe Gln Gly Phe Ser Ser Phe Arg 1 5 10 15 Glu His Gln Leu Gly Leu Phe Val Val Phe Leu Ala Leu Tyr Val Val

20 25 30

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Thr Leu Ala 35 Gly Asn Ala Val Ile Val Thr Ile Ile Arg Thr Asp Pro 40 45 His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Met Leu Ser Ser Ser 50 55 60 Glu Thr Val Tyr Thr Leu Val Ile Leu Pro Arg Met Leu Ser Ser Leu 65 70 75 80 Val Gly Thr Asn Arg Ser Ile Ser Arg Ala Gly Cys Ala Thr Gln Met 85 90 95 Phe Phe Phe Val Thr Phe Gly Ile Thr Asn Cys Phe Leu Leu Thr Ala 100 105 110 Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr Ser 115 120 125 Val Ile Met Asn Lys Arg Gly Cys Val Gln Leu Val Gly Gly Ala Cys 130 135 140 Gly Ile Gly Leu Ile Val Ala Thr Thr Gln Val Thr Ser Val Phe Arg 145 150 155 160 Leu Pro Phe Cys Ala Thr Lys Val Ala His Phe Phe Cys Asp Ile Arg 165 170 175 Pro Val Met Lys Leu Ser Cys Val Asp Thr Ser Val Asn Glu Thr Leu 180 185 190 Thr Val Ile Ile Ser Val Leu Val Leu Val Val Pro Met Gly Leu Val 195 200 205 Phe Ile Ser Tyr Val Leu Ile Val Ser Thr Val Leu Lys Ile Pro Ser 210 215 220 Ala Arg Gly Arg Lys Lys Ala Phe Ala Thr Cys Ala Ser His Leu Thr 225 230 235 240

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Val Val Val Val His Tyr Gly Cys Ala Ser Val Ala Tyr Leu Lys Pro 245 250 255 Lys Ser Glu Asn Thr Arg Asp Gln Asp Gln Leu Ile Ser Val Thr Tyr 260 265 270 Thr Val Ile Thr Pro Leu Leu Asn Pro Val Val Tyr Thr Leu Arg Asn 275 280 285 Lys Glu Val Lys Asp Ala Leu Leu Arg Ala Ala Gly Arg Lys Leu Ser 290 295 300

<210> 3681 <211> 906 <212> DNA <213> Felis catus <400> 3681

gagaggattt ttgcccaaag ctctgagcaa ggcatccttg atgtctttgt tcctcaggct 60 gtacacaaca gggttgagga ggggtgtgat gaccgtgtag gtcacggaga tgagtctgtc 120 cttcagggag ttgtgagatt tgggttttag gtagatgacg gaggcgcagc cgtagtggac 180 gacgaccacc gtgaggtggg aggcgcaggt ggcaaaggcc ttcttccggc cccgggcaga 240 ggggatcttg aggatggtgg agacaatcag gacgtaggag atgaagatca gcaccatggg 300 cagaacaagg acacacagac tgatgagcaa ggtgacaagt tctttgatgg tggtgtcagc 360 acaggccagc tgcatcaggg gccggatgtc acagaagaag tgggagatga cattggcatc 420 acagaagggc aggctgaaca cagacgacac ctgaatgatg gccgtgctca ggccaatgct 480 ccaggagcca ctcgccaatt gtagacaagt ccttttgccc atgacgacgg aataccgcag 540 ggggttgcag atggccgcgt agcggtcata ccccatggcc gtgagcagga agcagttgtt 600 gatgccgaag gcgagataga agaagagctg agtggcacag tgtgggatgg agatggctcg 660 ttggggactg aggagactgg acagcatgca ggggatgatg gccactgtat aacaggtctc 720 agagatggac agtacgctca ggaagaagta catgggtgtg tgaagttgac ggttgaggcg 780 gataacggtc aagatgatgg cattgctggc gagggtcaac aggtacaaga ccagaaagac 840 cacaaagaga atgagtctgt gctgccaccc caaaacggaa aaaccttcaa aggtgaactc 900

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069269_0225_SL.TXT tgtcac

906 <210> 3682 <211> 302 <212> PRT <213> Felis catus

<400> 3682 Val 1 Thr Glu Phe Thr 5 Phe Glu Gly Phe Ser Val Leu Gly Trp Gln His 10 15 Arg Leu Ile Leu Phe Val Val Phe Leu Val Leu Tyr Leu Leu Thr Leu 20 25 30 Ala Ser Asn Ala Ile Ile Leu Thr Val Ile Arg Leu Asn Arg Gln Leu 35 40 45 His Thr Pro Met Tyr Phe Phe Leu Ser Val Leu Ser Ile Ser Glu Thr 50 55 60 Cys Tyr Thr Val Ala Ile Ile Pro Cys Met Leu Ser Ser Leu Leu Ser 65 70 75 80 Pro Gln Arg Ala Ile Ser Ile Pro His Cys Ala Thr Gln Leu Phe Phe 85 90 95 Tyr Leu Ala Phe Gly Ile Asn Asn Cys Phe Leu Leu Thr Ala Met Gly 100 105 110 Tyr Asp Arg Tyr Ala Ala Ile Cys Asn Pro Leu Arg Tyr Ser Val Val 115 120 125 Met Gly Lys Arg Thr Cys Leu Gln Leu Ala Ser Gly Ser Trp Ser Ile 130 135 140 Gly Leu Ser Thr Ala Ile Ile Gln Val Ser Ser Val Phe Ser Leu Pro 145 150 155 160 Phe Cys Asp Ala Asn Val Ile Ser His Phe Phe Cys Asp Ile Arg Pro 165 170 175

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Leu Met Gln Leu 180 Ala Cys Ala Asp Leu Leu Ile 195 Ser Leu Cys Val Leu 200 Ile Ser 210 Tyr Val Leu Ile Val 215 Ser Arg 225 Gly Arg Lys Lys Ala 230 Phe Ala Val Val Val His Tyr 245 Gly Cys Ala Ser His Asn Ser 260 Leu Lys Asp Arg Ile Thr Pro 275 Leu Leu Asn Pro Val 280 Ile Lys 290 Asp Ala Leu Leu Arg 295 Ala

Thr 185 Thr Ile Lys Glu Leu 190 Val Thr Val Leu Pro Met Val 205 Leu Ile Phe Thr Ile Leu Lys 220 Ile Pro Ser Ala Thr Cys Ala 235 Ser His Leu Thr Val 240 Ser Val 250 Ile Tyr Leu Lys Pro 255 Lys Leu 265 Ile Ser Val Thr Tyr 270 Thr Val Val Tyr Ser Leu Arg 285 Asn Lys Asp Leu Gly Lys Asn 300 Pro Leu

<210> 3683 <211> 920 <212> DNA <213> Felis catus <400> 3683 tcaggaaagc ttcctgccag cggcccggag ggtatacacc accgggttca gcaggggggt gtcctgatcc ctggtgttct ccgacttggg gtggacgacg accaccgtga ggtgagaggc ggcggagggg atcttgagga cggtggagac catggggacc aggatcacca gcacgctgat cagagcatcc ttgacctcct tgttcctcag gatgacggtg taggtcaccg agatcagctg cttgaggtag gcgacggagg cacagccgta gcaggtggca aaggccttct tccggccccg gatgaggacg taggagatga agaccaggcc gatcacggtc agggtctcgt tgaccgaggt

120

180

240

300

360

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gtcgacgcag gagagcttca ttacaggtcg gatgtcacag aagaagtggg ccaccttcgt 420 agcacagaaa ggcaacctga acacagatgt cacttgtgtc gtcgccacga tcagcccaat 480 gccgcaggcg ccccccacca actgcacaca caccctcttg ttcatgatga ccgtgtacct 540 caaggggttg cagatggcca cgtagcggtc gtaccccatc gccgtgagca ggaagcagtt 600 gttgatggcc aaggtgatga agaagaacat ctgggtggca cagccagcca aggagatggg 660 ctgactcagg cctacaaggt tacagagcat tttgggtata atgacgagtg tatatacggt 720 ctctgaagtg gacagcatgc tcaggaagaa gtacatgggc gtgtggaggt gacgatccac 780 actaatgatg gtcacgatga cgacgttgcc ggccagggtt acgacgtaca gtgcaaggaa 840 cacaacaaac aggctgagct ggtgctcgtg gaagctggag aagccctgga aagtgaactc 900 actcacccaa gtgtgattct 920 <210> 3684 <211> 305 <212> PRT <213> Felis catus <400> 3684 Asn His Thr Trp Val Ser Glu Phe Thr Phe Gln Gly Phe Ser Ser Phe 1 5 10 15 His Glu His Gln Leu Ser Leu Phe Val Val Phe Leu Ala Leu Tyr Val 20 25 30 Val Thr Leu Ala Gly Asn Val Val Ile Val Thr Ile Ile Ser Val Asp 35 40 45 Arg His Leu His Thr Pro Met Tyr Phe Phe Leu Ser Met Leu Ser Thr 50 55 60 Ser Glu Thr Val Tyr Thr Leu Val Ile Ile Pro Lys Met Leu Cys Asn 65 70 75 80 Leu Val Gly Leu Ser Gln Pro Ile Ser Leu Ala Gly Cys Ala Thr Gln 85 90 95 Met Phe Phe Phe Ile Thr Leu Ala Ile Asn Asn Cys Phe Leu Leu Thr

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100

069269_0225_SL.TXT 105 110

Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro Leu Arg Tyr 115 120 125

Thr Val Ile Met Asn Lys Arg Val Cys Val Gln Leu Val Gly Gly Ala 130 135 140

Cys Gly Ile Gly Leu Ile Val Ala Thr Thr Gln Val Thr Ser Val Phe 145 150 155 160

Arg Leu Pro Phe Cys Ala Thr Lys Val Ala His Phe Phe Cys Asp Ile 165 170 175

Arg Pro Val Met Lys Leu Ser Cys Val Asp Thr Ser Val Asn Glu Thr 180 185 190

Leu Thr Val Ile Ile Ser Val Leu Val Ile Leu Val Pro Met Gly Leu 195 200 205

Val Phe Ile Ser Tyr Val Leu Ile Val Ser Thr Val Leu Lys Ile Pro 210 215 220

Ser Ala Arg Gly Arg Lys Lys Ala Phe Ala Thr Cys Ala Ser His Leu 225 230 235 240

Thr Val Val Val Val His Tyr Gly Cys Ala Ser Val Ala Tyr Leu Lys 245 250 255

Pro Lys Ser Glu Asn Thr Arg Asp Gln Asp Gln Leu Ile Ser Val Thr 260 265 270

Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Val Val Tyr Thr Leu Arg 275 280 285

Asn Lys Glu Val Lys Asp Ala Leu Leu Arg Ala Ala Gly Arg Lys Leu 290 295 300

Ser

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305 <210> 3685 <211> 933 <212> DNA <213> Felis catus <400> 3685

ttagggaagg gatttcctcc ccaccactct cctcagagca tcctggactt ctttgtttct 60 cagactgtac acaacagggt tcagcaatgg tgttatcaca gtgtaggtca ctgagattaa 120 ctggtcctga tccttggtgt tctctgactt gggcttgaag taggcgatag aagcacagcc 180 atagtggata atgaccaccg tgaggtggga ggagcaagtg gcaaaggctt tcttccggcc 240 ctcagctgag gcaatcttga ggatggtaga gatgatgagg aagtaggaga tgaggaggaa 300 agtggcaggg gctgtgatgg ccaagaggct tatagttaag gtcaagatat cattaacgat 360 tggagtaaca caggctaaat ccaacacagg tcgaacatca cagaagaagt gctcaatcag 420 tgagttacag aaaggcagtc ggaaaatggc cacagcctga accagagaga gcaagaaccc 480 cgaggcacag accgaggatg ccagaatggt acaggccctc caattcatga caattgggta 540 acgaagtggg ttgcagatgg ccacgtagcg atcaaacccc atgactgcta gcaggaggca 600 gttggtgatg gcaaagccaa ggaagaaaaa gagctgagtc ccacagccca ccagggagat 660 ggactggctc agacccacga ggccggaaag catgcgtggg atgatgacca gggaatagca 720 cgtctctgat gtggagagaa cacttagaaa gaagtacatg ggggtgtgga ggtggtggtc 780 aacacggata atagtcacga tgatgacatt gccggccaga gttaagaggt acagggttag 840 gaacacggca aacagtatga gttgatgttc tcggaagttg gagaaacctt ggaaaacaaa 900 ccccctcacc tctgtgtgat tggctgtctt cat 933

<210> 3686 <211> 310 <212> PRT <213> Felis catus <400> 3686

Met Lys Thr Ala Asn His Thr Glu Val Arg Gly Phe Val Phe Gln Gly 1 5 10 15

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Phe Ser Asn Phe 20 Arg Glu His Gln Leu Ile Leu Phe Ala Val Phe Leu 25 30 Thr Leu Tyr Leu Leu Thr Leu Ala Gly Asn Val Ile Ile Val Thr Ile 35 40 45 Ile Arg Val Asp His His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 Val Leu Ser Thr Ser Glu Thr Cys Tyr Ser Leu Val Ile Ile Pro Arg 65 70 75 80 Met Leu Ser Gly Leu Val Gly Leu Ser Gln Ser Ile Ser Leu Val Gly 85 90 95 Cys Gly Thr Gln Leu Phe Phe Phe Leu Gly Phe Ala Ile Thr Asn Cys 100 105 110 Leu Leu Leu Ala Val Met Gly Phe Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Pro Ile Val Met Asn Trp Arg Ala Cys Thr Ile Leu 130 135 140 Ala Ser Ser Val Cys Ala Ser Gly Phe Leu Leu Ser Leu Val Gln Ala 145 150 155 160 Val Ala Ile Phe Arg Leu Pro Phe Cys Asn Ser Leu Ile Glu His Phe 165 170 175 Phe Cys Asp Val Arg Pro Val Leu Asp Leu Ala Cys Val Thr Pro Ile 180 185 190 Val Asn Asp Ile Leu Thr Leu Thr Ile Ser Leu Leu Ala Ile Thr Ala 195 200 205 Pro Ala Thr Phe Leu Leu Ile Ser Tyr Phe Leu Ile Ile Ser Thr Ile 210 215 220

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Leu 225 Lys Ile Ala Ser Ala 230 Glu 069269_0225_SL.TXT Ala Thr Cys 240 Gly Arg Lys Lys Ala Phe 235 Ser Ser His Leu Thr Val Val Ile Ile His Tyr Gly Cys Ala Ser Ile 245 250 255 Ala Tyr Phe Lys Pro Lys Ser Glu Asn Thr Lys Asp Gln Asp Gln Leu 260 265 270 Ile Ser Val Thr Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Val Val 275 280 285 Tyr Ser Leu Arg Asn Lys Glu Val Gln Asp Ala Leu Arg Arg Val Val 290 295 300 Gly Arg Lys Ser Leu Pro 305 310

<210> 3687 <211> 911 <212> DNA <213> Felis catus

<400> 3687 gggtggccgc acaggctggt ctttgccgtc tttctgagtt tgcacctgct gactctgtcc 60 agcaatatca tcatcatcgt gactgttgtt cgtctgaacc atcacctcca tacccccatg 120 tacttcttcc tgagcatgct gtccctctct gagacctgct acactgtggc catcatctat 180 gcttcctggc ctcctgagtc cccaccagcc catttctgtc cagtctcctc agtccccaac 240 gagccatctc catcccagac tgtgccactc agctcttctt ctatctcacc ttcggcatca 300 acaactgctt cctgctcacg gccacggggt atgactgcta cgtgaccacc tgcaaccccc 360 tgtggtattc agtcatcatg agtaaagagg cctgtgtcca gttagcaagt ggctccctgg 420 gaactggcct gggcgtggcc actgtccagg taacatctgt gtttggcctg cccttctgtg 480 atgcccttgt catatttcac ttcttctgtg acgtcaggcc cctgctgaag ctggcctgcg 540 tggacacccc tgtcaacgag atcatcaact ttgtcgtcag cgtctgtgtc ctgattctgc 600 ccacgggcct ggtcttcttc tcctgtgtcc tcatcgtctc cgccagcctc aagatccccc 660

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069269_0225_SL.TXT ccgcccgggg ctggaagaag gcctttgcca cctgcacctc ccgcctcaga gtggtcatcg tccactatgg ctgtgcctct gtcgcctacc tcaagcccaa gtcccggagt tccctggggc aggacagact catctctgtg acctacaccg tcctcactcc cctgctgagc cctgtcgtgt acagcctgag gaacaaggaa gtcaaggatg ccctgcgcag aggcgtgggg cagaagcccc tttcctctta a

720

780

840

900

911 <210> 3688 <211> 177 <212> PRT <213> Felis catus <400> 3688

Met Ser 1 Lys Glu Ala 5 Cys Val Gln Leu Ala Ser Gly Ser Leu Gly Thr 10 15 Gly Leu Gly Val Ala Thr Val Gln Val Thr Ser Val Phe Gly Leu Pro 20 25 30 Phe Cys Asp Ala Leu Val Ile Phe His Phe Phe Cys Asp Val Arg Pro 35 40 45 Leu Leu Lys Leu Ala Cys Val Asp Thr Pro Val Asn Glu Ile Ile Asn 50 55 60 Phe Val Val Ser Val Cys Val Leu Ile Leu Pro Thr Gly Leu Val Phe 65 70 75 80 Phe Ser Cys Val Leu Ile Val Ser Ala Ser Leu Lys Ile Pro Pro Ala 85 90 95 Arg Gly Trp Lys Lys Ala Phe Ala Thr Cys Thr Ser Arg Leu Arg Val 100 105 110 Val Ile Val His Tyr Gly Cys Ala Ser Val Ala Tyr Leu Lys Pro Lys 115 120 125 Ser Arg Ser Ser Leu Gly Gln Asp Arg Leu Ile Ser Val Thr Tyr Thr 130 135 140

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Val Leu Thr Pro Leu Leu Ser Pro Val Val Tyr Ser Leu Arg Asn Lys 145 150 155 160

Glu Val Lys Asp Ala Leu Arg Arg Gly Val Gly Gln Lys Pro Leu Ser 165 170 175

Ser <210> 3689 <211> 933 <212> DNA <213> Felis catus <400> 3689 atgaagagag agaaccatac tgcggtgggt gaatttgttc tccagggttt ttccagcttt 60 cgtgaacaca agatcatcct ctttgtgata tttcttacct tgtacctttt aactctggct 120 ggcaatgtca tcattgtgac agtcatcagc tttgctcgtc acctgcacac ccccatgtac 180 ttcttccttg gtgttctttc cacttctgag actgtctaca cactggtcat tgtaccgcgg 240 atgctttgca gcctcacagg cctgagtcag cccatctcct tggctggctg tgccacccag 300 atgttcttct tcatcacctt ggccatcaac aactgcttcc tgctcacggc gatggggtac 360 gaccgctacg tggccatctg caaccccttg aggtacacgg tcatcatgaa caagagggcg 420 tgtgccctgc tcgtatcagg ggcttgcagc attgggctgt ttgtggccat cattcagatt 480 tcctctgtat tcagactgcc cttttgtgac agagaggtgg cccactattt ctgtgacatc 540 cgcccagtta tgaaactctc ctgtgctgat accactctac atgacataat taattttatc 600 atcagctcac tcgttattgt ggttcccatg ggcctggtct tcatctccta catcctcatc 660 gtctccacca tcctcaagat cccctccgcc cggggccgga agaaggcctt tgccacctgc 720 gcctctcacc tcacggtggt cgtcttccac tacggctgtg cctccgtcgc ctacctcaag 780 cccaagtcgg agaacaccag ggatcaggac cagctgatct cggtgaccta caccgtcatc 840 acccccctgc tgaacccggt tgtgtacacc ctgaggaaca aggaggtcaa ggatgctctt 900 caccgtgcta ttcgcaaaaa ccctcttgct tag 933

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069269_0225_SL.TXT <210> 3690 <211> 310 <212> PRT <213> Felis catus <400> 3690

Met 1 Lys Arg Glu Asn His Thr 5 Ala Val Gly Glu Phe Val Leu Gln Gly 10 15 Phe Ser Ser Phe Arg Glu His Lys Ile Ile Leu Phe Val Ile Phe Leu 20 25 30 Thr Leu Tyr Leu Leu Thr Leu Ala Gly Asn Val Ile Ile Val Thr Val 35 40 45 Ile Ser Phe Ala Arg His Leu His Thr Pro Met Tyr Phe Phe Leu Gly 50 55 60 Val Leu Ser Thr Ser Glu Thr Val Tyr Thr Leu Val Ile Val Pro Arg 65 70 75 80 Met Leu Cys Ser Leu Thr Gly Leu Ser Gln Pro Ile Ser Leu Ala Gly 85 90 95 Cys Ala Thr Gln Met Phe Phe Phe Ile Thr Leu Ala Ile Asn Asn Cys 100 105 110 Phe Leu Leu Thr Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Thr Val Ile Met Asn Lys Arg Ala Cys Ala Leu Leu 130 135 140 Val Ser Gly Ala Cys Ser Ile Gly Leu Phe Val Ala Ile Ile Gln Ile 145 150 155 160 Ser Ser Val Phe Arg Leu Pro Phe Cys Asp Arg Glu Val Ala His Tyr 165 170 175 Phe Cys Asp Ile Arg Pro Val Met Lys Leu Ser Cys Ala Asp Thr Thr 180 185 190

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Leu His Asp Ile Ile Asn Phe Ile Ile Ser Ser Leu Val Ile Val Val 195 200 205 Pro Met Gly Leu Val Phe Ile Ser Tyr Ile Leu Ile Val Ser Thr Ile 210 215 220 Leu Lys Ile Pro Ser Ala Arg Gly Arg Lys Lys Ala Phe Ala Thr Cys 225 230 235 240 Ala Ser His Leu Thr Val Val Val Phe His Tyr Gly Cys Ala Ser Val 245 250 255 Ala Tyr Leu Lys Pro Lys Ser Glu Asn Thr Arg Asp Gln Asp Gln Leu 260 265 270 Ile Ser Val Thr Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Val Val 275 280 285 Tyr Thr Leu Arg Asn Lys Glu Val Lys Asp Ala Leu His Arg Ala Ile 290 295 300 Arg Lys Asn Pro Leu Ala

305 310 <210> 3691 <211> 945 <212> DNA <213> Felis catus <400> 3691 atggatccgc tcaaccacac gtggacccag agtttcatcc tctctggttt cagtgtcccc ggaaccctgc gacctcttgc cttcttgggg accctgtgcc tctatctcct cacactgtct gggaacctct tcatcgttgt cctggtccag gtggatgctg gactgtccac gcccatgtac ttcttcatcg gcgtcctctc cttcctggag ctcgggtacg tcagcgccac ggtgcccacg ctgctgcaca cgtggctccg tgggcgctca gccatctcgg cagcggtgtg cttcatccag ctgtacgtct tccactctct gggcatgacc gagtgccatc tgctgggcgt catggcgctg

120

180

240

300

360

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gaccgctacc tggccatctg ccgcccgctc cactaccggg cactcatgac cagaaaggtc 420 cagttctggc tggcaggggc cgcttgggtg gctggcttct cagcggcact ggtgccagcc 480 agcctcacgg ccaccctgcc cttctgtctg aaagaggtgg cccactactt ctgtgacctg 540 gcacctttga tgcggttggc gtgcgtggac gcaggctggc acgctcgagt gcacggggcg 600 gtgattggtg cggccactgg ctgcaacttc gtgctcattt ggggactcta cgggggcatc 660 ttgagggccg tgctgaagct gccctcggct gccagccggg tcaaggcctt ctccacctgc 720 tcctcccaca tgatcgtggt ggccctcttt tatgcctccg ccttcacggt ctatgtgggg 780 ccacctggga accgctctga gggcacagac aagtgtatcg ccttggtgta tgcccttctc 840 actcctctcc tcaaccccat cgtctatacc cttcgcaaca aggaagtgag ggaggccgtg 900 aagagggtca ctgtcagggt caggactatt ctgaagggac cctga 945 <210> 3692 <211> 314 <212> PRT <213> Felis catus <400> 3692 Met Asp Pro Leu Asn His Thr Trp Thr Gln Ser Phe Ile Leu Ser Gly 1 5 10 15 Phe Ser Val Pro Gly Thr Leu Arg Pro Leu Ala Phe Leu Gly Thr Leu 20 25 30 Cys Leu Tyr Leu Leu Thr Leu Ser Gly Asn Leu Phe Ile Val Val Leu 35 40 45 Val Gln Val Asp Ala Gly Leu Ser Thr Pro Met Tyr Phe Phe Ile Gly 50 55 60 Val Leu Ser Phe Leu Glu Leu Gly Tyr Val Ser Ala Thr Val Pro Thr 65 70 75 80 Leu Leu His Thr Trp Leu Arg Gly Arg Ser Ala Ile Ser Ala Ala Val 85 90 95 Cys Phe Ile Gln Leu Tyr Val Phe His Ser Leu Gly Met Thr Glu Cys

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100

069269_0225_SL.TXT 105 110

His Leu Leu Gly Val Met Ala Leu Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Arg Ala Leu Met Thr Arg Lys Val Gln Phe Trp Leu 130 135 140 Ala Gly Ala Ala Trp Val Ala Gly Phe Ser Ala Ala Leu Val Pro Ala 145 150 155 160 Ser Leu Thr Ala Thr Leu Pro Phe Cys Leu Lys Glu Val Ala His Tyr 165 170 175 Phe Cys Asp Leu Ala Pro Leu Met Arg Leu Ala Cys Val Asp Ala Gly 180 185 190 Trp His Ala Arg Val His Gly Ala Val Ile Gly Ala Ala Thr Gly Cys 195 200 205 Asn Phe Val Leu Ile Trp Gly Leu Tyr Gly Gly Ile Leu Arg Ala Val 210 215 220 Leu Lys Leu Pro Ser Ala Ala Ser Arg Val Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Met Ile Val Val Ala Leu Phe Tyr Ala Ser Ala Phe Thr 245 250 255 Val Tyr Val Gly Pro Pro Gly Asn Arg Ser Glu Gly Thr Asp Lys Cys 260 265 270 Ile Ala Leu Val Tyr Ala Leu Leu Thr Pro Leu Leu Asn Pro Ile Val 275 280 285 Tyr Thr Leu Arg Asn Lys Glu Val Arg Glu Ala Val Lys Arg Val Thr 290 295 300

Val Arg Val Arg Thr Ile Leu Lys Gly Pro

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305

310 <210> 3693 <211> 922 <212> DNA <213> Felis catus <400> 3693

atggaacgga gaaaccattc gagcctggcc gagttcgtgt tccttggttt ccccaaagtg 60 ggacatgtca ggggctggct ttttgccctg ttgctgttgg catatctgtt cactttctgc 120 ggcaacttgc tcaccttctt ggccatacga ctgaacgcgg ccctgcacac acccatgtac 180 cactttgtca gtatactctc cttattggaa ctgtggtata cagccaccac catccccagc 240 atgctagcca atcttctccg tgagaagaag accatttctt ttgccggatg cctccttcag 300 acctacttct tccactctct aggggcctcg gaatgctacc ttcttacagc catggcctat 360 gaccgatacc tggccatctg ccggcccctc cactaccctg cagtcatgac cccgacactc 420 tgtggcaagt tggctgctgg ttgttggact tgtggcttcc tgtgtcccat ttctgaagta 480 tcctggtctc ccagctcccc ttttgtggct ataatgaaat tcaacacatc ttctgtgact 540 ttccacctct gctgagcctg gcctgcaagg acacatccac gaatgtcctt gtggactttg 600 ctatcaacgc ctttatcatc cttatcacct tcctctttat tatggtttct tatggaagaa 660 tcatcagtgc tgtactgaag ataaaaacag ccgaaggaag aaagaaggcc ttctctacct 720 gtgcctcaca tctcactgtg gttctcatct tttttgggag tatcattttc atgtacgtgc 780 gcctaaagaa gagctattcc ctgacccttg accgcacact tgctgtagtc tactctgtac 840 taacaccact cgtcaaccca attatctaca gtcttcgtaa caaggaactc attaaggcca 900 tcaagaggac catctgccag aa 922

<210> 3694 <211> 184 <212> PRT <213> Felis catus <400> 3694

Met Glu Arg Arg Asn His Ser Ser Leu Ala Glu Phe Val Phe Leu Gly 1 5 10 15

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Phe Pro Lys Val Gly His Val Arg Gly Trp Leu Phe Ala Leu Leu Leu 20 25 30 Leu Ala Tyr Leu Phe Thr Phe Cys Gly Asn Leu Leu Thr Phe Leu Ala 35 40 45 Ile Arg Leu Asn Ala Ala Leu His Thr Pro Met Tyr His Phe Val Ser 50 55 60 Ile Leu Ser Leu Leu Glu Leu Trp Tyr Thr Ala Thr Thr Ile Pro Ser 65 70 75 80 Met Leu Ala Asn Leu Leu Arg Glu Lys Lys Thr Ile Ser Phe Ala Gly 85 90 95 Cys Leu Leu Gln Thr Tyr Phe Phe His Ser Leu Gly Ala Ser Glu Cys 100 105 110 Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Pro Ala Val Met Thr Pro Thr Leu Cys Gly Lys Leu 130 135 140 Ala Ala Gly Cys Trp Thr Cys Gly Phe Leu Cys Pro Ile Ser Glu Val 145 150 155 160 Ser Trp Ser Pro Ser Ser Pro Phe Val Ala Ile Met Lys Phe Asn Thr 165 170 175 Ser Ser Val Thr Phe His Leu Cys

180 <210> 3695 <211> 946 <212> DNA <213> Felis catus <400> 3695 atgaatggtg agccatggat gctgggaatt ggagccaggt aacagagttc atcatcttgg

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gctttcccca tctccagggt atccaggctt acctcttcgt cttgttactt ctaatttatg 120 tcaccaccgt actgggaaac ctgctggtat tcctagtggt ccgcctggac tcccagctcc 180 acacacccat gtaccacttt gtcagcatcc tctccctgct ggagcttggc tacacggctg 240 ccaccgtccc caagatgctg tcgaacctgc tcagggagga gaagaccatt tctttctccg 300 gatgcctcct gcaaatctac ttctttcact ctcttggggc cactgagtgc tatctcctca 360 cagctatggc ttatgacagg tatttagcca tctgccggcc cctccactac tccaccctca 420 tgaccccagc acgctgcgcc aagatcgccg ttggctgttg gttgggaggt ctggctgggc 480 cggtggctga gatttccctg gtgtcccgtc tccctttctg tggccccaat cgcattcagc 540 acatcttttg tgatttccca cccgtgctga gcttggcttg tactgacaca tctatcaacg 600 tcctagtgga ctttgctatc aactcctgca agatcctggc caccttcctg ttgatcctca 660 gctcctatgt ccagatcgtc cgcacggtgc tcaggattcc ttcggttgca ggcaagacca 720 aagccttctc cacctgtgcc tcccacctga ctgtggttct catcttctac gggagcatcc 780 tctttatgta tgtgcggctg aagagtagct actcactgga ctatgaccgc gccctggctg 840 tgatctactc ggtgctcaca cctttcctca accccttcgt ctatagcttg cgcaacaagg 900 atattaagga ggccgtgagg aggcagttga agaggtcagg gatact 946 <210> 3696 <211> 311 <212> PRT <213> Felis catus <400> 3696 Met Asp Ala Gly Asn Trp Ser Gln Val Thr Glu Phe Ile Ile Leu Gly 1 5 10 15 Phe Pro His Leu Gln Gly Ile Gln Ala Tyr Leu Phe Val Leu Leu Leu 20 25 30 Leu Ile Tyr Val Thr Thr Val Leu Gly Asn Leu Leu Val Phe Leu Val 35 40 45 Val Arg Leu Asp Ser Gln Leu His Thr Pro Met Tyr His Phe Val Ser 50 55 60

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Ile 65 Leu Ser Leu Leu Glu Leu Gly Tyr Thr Ala Ala Thr Val Pro Lys 70 75 80 Met Leu Ser Asn Leu Leu Arg Glu Glu Lys Thr Ile Ser Phe Ser Gly 85 90 95 Cys Leu Leu Gln Ile Tyr Phe Phe His Ser Leu Gly Ala Thr Glu Cys 100 105 110 Tyr Leu Leu Thr Ala Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Arg 115 120 125 Pro Leu His Tyr Ser Thr Leu Met Thr Pro Ala Arg Cys Ala Lys Ile 130 135 140 Ala Val Gly Cys Trp Leu Gly Gly Leu Ala Gly Pro Val Ala Glu Ile 145 150 155 160 Ser Leu Val Ser Arg Leu Pro Phe Cys Gly Pro Asn Arg Ile Gln His 165 170 175 Ile Phe Cys Asp Phe Pro Pro Val Leu Ser Leu Ala Cys Thr Asp Thr 180 185 190 Ser Ile Asn Val Leu Val Asp Phe Ala Ile Asn Ser Cys Lys Ile Leu 195 200 205 Ala Thr Phe Leu Leu Ile Leu Ser Ser Tyr Val Gln Ile Val Arg Thr 210 215 220 Val Leu Arg Ile Pro Ser Val Ala Gly Lys Thr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Leu Ile Phe Tyr Gly Ser Ile Leu 245 250 255 Phe Met Tyr Val Arg Leu Lys Ser Ser Tyr Ser Leu Asp Tyr Asp Arg 260 265 270

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Ala Leu Ala Val Ile Tyr Ser Val Leu Thr Pro Phe Leu Asn Pro Phe 275 280 285 Val Tyr Ser Leu Arg Asn Lys Asp Ile Lys Glu Ala Val Arg Arg Gln 290 295 300 Leu Lys Arg Ser Gly Ile Leu 305 310

<210> 3697 <211> 942 <212> DNA <213> Felis catus <400> 3697

cccgacccca ctagccctcc tccgacggca gaaaagcctt ccaagagcat ctttcatgtc 60 cttgtttctg aggctgtaga taatggggtt caggaagggg gcaaggatga caaaagtgat 120 agcaattgct gtgtcccaaa atacggagta ggtggctgag aatcgcaggt acatgacggc 180 gacactgccg aaaaacagca agaacacagc caggtgggcg gcgcaggtag aaaaggcctt 240 gcggcggccc tcggccgagg gcatccccag aatcaccacg atgatccgga tgtaggatag 300 ggcgatggcc aggaaggagg ccacaatctc ccctgcatgg atggcgtcca caatgaccgc 360 cagggacgtg tccgtgcagg ccaagctcag cacgggcgta aagtcgcaga atatctgccg 420 gatctggttg gagccacaga aaggcagggt ggcaatccac acgatctcgg gaagcacgag 480 gaggaagcca cagacgcagg acccagcggc cagctgggtg cacagcctgg gagtcatgat 540 ggtcgcgtac cggagaggcc tgcagatggc gacgtacctg tcaatggcca tggccgtcag 600 gacgcagcct tctgtgatgc ccagggagtg gaagaaatac atctgtagga ggcagccagc 660 cacagagatg gtcttgtgct cactgatcag gctggagagc atcttgggga tggtggtcgt 720 ggtgtaccag atctccagga aagagaggac gctgatgaag aaatacatgg gggtgtgcag 780 ggccctgtcc agccggacga cgatgaatat cattaggttc ccagttacga taaatccgta 840 ggtgagaagc agaagaacga agaagaggac gccaccttca ggcagatgtg ggaacacaga 900 gaagaggaac tcagtcaccg tagtcaaatt cccactggtc ac 942

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069269_0225_SL.TXT <210> 3698 <211> 314 <212> PRT <213> Felis catus

<400> 3698 Val 1 Thr Ser Gly Asn Leu Thr Thr 5 Val Thr 10 Glu Phe Leu Phe Ser Val 15 Phe Pro His Leu Pro Glu Gly Gly Val Leu Phe Phe Val Leu Leu Leu 20 25 30 Leu Thr Tyr Gly Phe Ile Val Thr Gly Asn Leu Met Ile Phe Ile Val 35 40 45 Val Arg Leu Asp Arg Ala Leu His Thr Pro Met Tyr Phe Phe Ile Ser 50 55 60 Val Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Thr Thr Ile Pro Lys 65 70 75 80 Met Leu Ser Ser Leu Ile Ser Glu His Lys Thr Ile Ser Val Ala Gly 85 90 95 Cys Leu Leu Gln Met Tyr Phe Phe His Ser Leu Gly Ile Thr Glu Gly 100 105 110 Cys Val Leu Thr Ala Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Arg 115 120 125 Pro Leu Arg Tyr Ala Thr Ile Met Thr Pro Arg Leu Cys Thr Gln Leu 130 135 140 Ala Ala Gly Ser Cys Val Cys Gly Phe Leu Leu Val Leu Pro Glu Ile 145 150 155 160 Val Trp Ile Ala Thr Leu Pro Phe Cys Gly Ser Asn Gln Ile Arg Gln 165 170 175 Ile Phe Cys Asp Phe Thr Pro Val Leu Ser Leu Ala Cys Thr Asp Thr 180 185 190

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Ser Leu Ala 195 Val Ile Val Asp Ala Ile His Ala Gly Glu Ile Val Ala 200 205 Ser Phe Leu Ala Ile Ala Leu Ser Tyr Ile Arg Ile Ile Val Val Ile 210 215 220 Leu Gly Met Pro Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ala His Leu Ala Val Phe Leu Leu Phe Phe Gly Ser Val Ala Val 245 250 255 Met Tyr Leu Arg Phe Ser Ala Thr Tyr Ser Val Phe Trp Asp Thr Ala 260 265 270 Ile Ala Ile Thr Phe Val Ile Leu Ala Pro Phe Leu Asn Pro Ile Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Met Lys Asp Ala Leu Gly Arg Leu Phe 290 295 300 Cys Arg Arg Arg Arg Ala Ser Gly Val Gly 305 310

<210> 3699 <211> 918 <212> DNA <213> Felis catus <400> 3699

cagtgacgga gtttctcttc tctggattcc cccagtttga agacggcagc ctcctcttct 60 tcattccttt gttcatcatc tacatcttca ttgtgattgg aaatctcatt gtattttttg 120 cagtcaggat ggacacccgt ctccacaacc ccatgtacaa tttcatcagc atcttctcct 180 ttctggagat ctggtacaca acagccacca tccccaagat gctctccaac ctcatctgcg 240 agaagaagac catctccatt actggctgcc tcctgcagat gtacttcttc cattcactgg 300 gaaattccga ggggattttg ttgaccacca tggccattga caggtacatt gccatctgca 360

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accctctccg ctacccgacc attatgaccc cccagctgtg tgctcagctc tctgcaggct 420 cctgcctctt tggctttctt gtgttgctcc cagagattgt ttggatttcc accctgcctt 480 tctgcgggcc caaccaaatc catcagatat tttgtgactt tgaacctgta ctgcgcttgg 540 cttgtacaga cacgtccatg atcctgcttg aggatgtgat ccatgctgcg gccatcatct 600 tctctgtcct ggttatcgct gtctcttatg tcagaatcat cactgtgacc ctgaggatcc 660 cgtctgccga aggccgccgg aaggccttct cgacctgtgc gtctcatctt ggtgtctttc 720 tgatgttcta tggcagcgtg tccctcatgt acctgcgctt ctctgccact ttcccaccaa 780 ctttggacac agtcattgca ctgatgtttg ccgttctcgc tccctttttc aaccctatca 840 tctatagttt gagaaacaag gacatgaaga ttgcgattaa gaagcttctc tgccttcaga 900 aggtgtttaa tgcacctg 918

<210> 3700 <211> 306 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (306)..(306) <223> Any amino acid <400> 3700

Val Thr Glu Phe Leu Phe Ser Gly Phe Pro Gln Phe Glu Asp Gly Ser 1 5 10 15

Leu Leu Phe Phe Ile Pro Leu Phe Ile Ile Tyr Ile Phe Ile Val Ile 20 25 30

Gly Asn Leu Ile Val Phe Phe Ala Val Arg Met Asp Thr Arg Leu His 35 40 45

Asn Pro Met Tyr Asn Phe Ile Ser Ile Phe Ser Phe Leu Glu Ile Trp 50 55 60

Tyr Thr Thr Ala Thr Ile Pro Lys Met Leu Ser Asn Leu Ile Cys Glu 65 70 75 80

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Lys Lys Thr Ile Ser 85 Ile Thr Gly Cys Leu Leu Gln Met Tyr Phe Phe 90 95 His Ser Leu Gly Asn Ser Glu Gly Ile Leu Leu Thr Thr Met Ala Ile 100 105 110 Asp Arg Tyr Ile Ala Ile Cys Asn Pro Leu Arg Tyr Pro Thr Ile Met 115 120 125 Thr Pro Gln Leu Cys Ala Gln Leu Ser Ala Gly Ser Cys Leu Phe Gly 130 135 140 Phe Leu Val Leu Leu Pro Glu Ile Val Trp Ile Ser Thr Leu Pro Phe 145 150 155 160 Cys Gly Pro Asn Gln Ile His Gln Ile Phe Cys Asp Phe Glu Pro Val 165 170 175 Leu Arg Leu Ala Cys Thr Asp Thr Ser Met Ile Leu Leu Glu Asp Val 180 185 190 Ile His Ala Ala Ala Ile Ile Phe Ser Val Leu Val Ile Ala Val Ser 195 200 205 Tyr Val Arg Ile Ile Thr Val Thr Leu Arg Ile Pro Ser Ala Glu Gly 210 215 220 Arg Arg Lys Ala Phe Ser Thr Cys Ala Ser His Leu Gly Val Phe Leu 225 230 235 240 Met Phe Tyr Gly Ser Val Ser Leu Met Tyr Leu Arg Phe Ser Ala Thr 245 250 255 Phe Pro Pro Thr Leu Asp Thr Val Ile Ala Leu Met Phe Ala Val Leu 260 265 270 Ala Pro Phe Phe Asn Pro Ile Ile Tyr Ser Leu Arg Asn Lys Asp Met 275 280 285

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Lys Ile Ala Ile Lys Lys Leu Leu Cys Leu Gln Lys Val Phe Asn Ala 290 295 300

Pro Xaa

305 <210> 3701 <211> 904 <212> DNA <213> Felis catus <400> 3701

ggaggggaaa cctgtcagcc gtgactgaat tcatcgtcac tggcttcctg cagctccaag 60 atggtggcct cctgtacttc ttccccctac ttttcgtcta cacttttatt gtcatcagga 120 acctgatggt cttctttgct gcccggctgg acacccatcc tcacaacccc atgtacaatt 180 tcatcagcat cttcgccttc ctggggatcc ggtacatgac agccaccatc cccaagatgc 240 tctccaacct catctgtgag aagaagacca cctccattac tggctgcctc ctgcagatgt 300 acttcttcca ttcactggga aatcccgagg ggatgctgtt gaccaccatg gccatcgaca 360 tgtccgtggc catctgcgac cctctccgct accagaccat cctgaccccc tggctgtgtg 420 ctcggctctc tgcaggctcc tgcatcttgg gtctcctcat cctgcttcct gagattgtga 480 tgatttccac accgcttctc tgtgggcccg accaaatctg tcaaatcttc tgtgacttgg 540 tcctcacgct gagcctggcc tgtacagaca cgtccacgat tctggttgga gatgtgatcc 600 atgctgtggc catcatcgtt accgtcctaa tcattgccct gttctctatc aggatggtca 660 ctgtggtcct gaggatcccc tctgctgagg gcgggcgaaa ggccttttct acctgtgcag 720 gccatctcgc tgtgtccctg attttcttag gccacgtgtc cctcatgtac tcacgattca 780 atgccaccta cctcccagtc ctggacacca caactgcact gatgtttatt atctttgccc 840 ccttcttcaa tcccatcatc tatagtctga gaaacaagga catgaagaac acgattagaa 900

cact 904 <210> 3702 <211> 301 <212> PRT <213> Felis catus

Page 4147

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<400> 3702 Ser Ala Val Thr Glu Phe Ile Val Thr Gly Phe 15 Leu Arg 1 Gly Asn Leu 5 10 Gln Leu Gln Asp Gly Gly Leu Leu Tyr Phe Phe Pro Leu Leu Phe Val 20 25 30 Tyr Thr Phe Ile Val Ile Arg Asn Leu Met Val Phe Phe Ala Ala Arg 35 40 45 Leu Asp Thr His Pro His Asn Pro Met Tyr Asn Phe Ile Ser Ile Phe 50 55 60 Ala Phe Leu Gly Ile Arg Tyr Met Thr Ala Thr Ile Pro Lys Met Leu 65 70 75 80 Ser Asn Leu Ile Cys Glu Lys Lys Thr Thr Ser Ile Thr Gly Cys Leu 85 90 95 Leu Gln Met Tyr Phe Phe His Ser Leu Gly Asn Pro Glu Gly Met Leu 100 105 110 Leu Thr Thr Met Ala Ile Asp Met Ser Val Ala Ile Cys Asp Pro Leu 115 120 125 Arg Tyr Gln Thr Ile Leu Thr Pro Trp Leu Cys Ala Arg Leu Ser Ala 130 135 140 Gly Ser Cys Ile Leu Gly Leu Leu Ile Leu Leu Pro Glu Ile Val Met 145 150 155 160 Ile Ser Thr Pro Leu Leu Cys Gly Pro Asp Gln Ile Cys Gln Ile Phe 165 170 175 Cys Asp Leu Val Leu Thr Leu Ser Leu Ala Cys Thr Asp Thr Ser Thr 180 185 190 Ile Leu Val Gly Asp Val Ile His Ala Val Ala Ile Ile Val Thr Val 195 200 205

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Leu Ile 210 Ile Ala Leu Phe Ser Ile Arg Met Val Thr Val Val Leu Arg 215 220 Ile Pro Ser Ala Glu Gly Gly Arg Lys Ala Phe Ser Thr Cys Ala Gly 225 230 235 240 His Leu Ala Val Ser Leu Ile Phe Leu Gly His Val Ser Leu Met Tyr 245 250 255 Ser Arg Phe Asn Ala Thr Tyr Leu Pro Val Leu Asp Thr Thr Thr Ala 260 265 270 Leu Met Phe Ile Ile Phe Ala Pro Phe Phe Asn Pro Ile Ile Tyr Ser 275 280 285 Leu Arg Asn Lys Asp Met Lys Asn Thr Ile Arg Thr Leu 290 295 300

<210> 3703 <211> 946 <212> DNA <213> Felis catus <400> 3703

atggagagtg aaaatctatc agctgtgact gaattcatct tcactggctt cccgcagctc 60 caagatggcg gcctcctgta cttcttcccc ctccttttcg tctacacctt tattgtcgtt 120 gggaacctga tggtcttctt tgctgtccgg ctggacaccc gtctccacaa ccccatgtac 180 aatttcatca gtatcttctc atttctggag atctggtaca ccacggccac catccccaag 240 atgctctcca atctgatcag cagccaaaag accatctcct tgactggctg cctcttgcaa 300 atgtacttct tccattcact cggaaacact gaaggagcct tgctgaccat catggccatc 360 gacagatacg ttgccatctg caaccctctt cactacctga ccatcatgac cccccgacta 420 tgcgctcagc tttctgcagg ctcttgtgtc tttggtttcc tcatccttct acctgaggtt 480 gtatggattt ctaccctacc tttctgtggc cccaaccaaa tccatcagat cttctgtgat 540 ttcggtccat tattaaattt agcctgtacg gatgcctctg tgatcctagt gcaagacgtg 600

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attcatgctt cggccattct gataacgagt ctgattattt ccctttcgta catcagaatt 660 gtggttgtta tcctgggcat cccttcagcg gagggtcgta aaaaggcctt ctccacctgc 720 gtcgcccaca ttgccgtctt cctgatgttt tttggcagtg tggccctcat gtatctcaga 780 ttctctgcca cgtatacgcc gttctgggac acagccattg ctgtaacctt ctctgtcctt 840 tctccccttt tcaatcccat gatatacagc ctgagaaata atgatatgaa agatgctatt 900 aagaagctcc tttgccctca aaaggtgttt cgtgtacgtg gtaggt 946

<210> 3704 <211> 316 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (316)..(316) <223> Any amino acid <400> 3704

Met Glu Ser Glu Asn Leu Ser Ala Val Thr Glu Phe Ile Phe Thr Gly 1 5 10 15

Phe Pro Gln Leu Gln Asp Gly Gly Leu Leu Tyr Phe Phe Pro Leu Leu 20 25 30

Phe Val Tyr Thr Phe Ile Val Val Gly Asn Leu Met Val Phe Phe Ala 35 40 45

Val Arg Leu Asp Thr Arg Leu His Asn Pro Met Tyr Asn Phe Ile Ser 50 55 60

Ile Phe Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys 65 70 75 80

Met Leu Ser Asn Leu Ile Ser Ser Gln Lys Thr Ile Ser Leu Thr Gly 85 90 95

Cys Leu Leu Gln Met Tyr Phe Phe His Ser Leu Gly Asn Thr Glu Gly 100 105 110

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Ala Leu Leu 115 Thr Ile Met Ala Ile Asp Arg Tyr Val Ala Ile Cys Asn 120 125 Pro Leu His Tyr Leu Thr Ile Met Thr Pro Arg Leu Cys Ala Gln Leu 130 135 140 Ser Ala Gly Ser Cys Val Phe Gly Phe Leu Ile Leu Leu Pro Glu Val 145 150 155 160 Val Trp Ile Ser Thr Leu Pro Phe Cys Gly Pro Asn Gln Ile His Gln 165 170 175 Ile Phe Cys Asp Phe Gly Pro Leu Leu Asn Leu Ala Cys Thr Asp Ala 180 185 190 Ser Val Ile Leu Val Gln Asp Val Ile His Ala Ser Ala Ile Leu Ile 195 200 205 Thr Ser Leu Ile Ile Ser Leu Ser Tyr Ile Arg Ile Val Val Val Ile 210 215 220 Leu Gly Ile Pro Ser Ala Glu Gly Arg Lys Lys Ala Phe Ser Thr Cys 225 230 235 240 Val Ala His Ile Ala Val Phe Leu Met Phe Phe Gly Ser Val Ala Leu 245 250 255 Met Tyr Leu Arg Phe Ser Ala Thr Tyr Thr Pro Phe Trp Asp Thr Ala 260 265 270 Ile Ala Val Thr Phe Ser Val Leu Ser Pro Leu Phe Asn Pro Met Ile 275 280 285 Tyr Ser Leu Arg Asn Asn Asp Met Lys Asp Ala Ile Lys Lys Leu Leu 290 295 300 Cys Pro Gln Lys Val Phe Arg Val Arg Gly Arg Xaa

305 310 315

Page 4151

069269_0225_SL.TXT <210> 3705 <211> 963 <212> DNA <213> Felis catus <400> 3705 atggagagcc ccaatcaaag tggggaagtt ctgtcacctg ggaaaccttg tcatcatcgc ttcttcatcg gcaccctttc atgcttgcca gcctgctcgg tatttcttcc attccactgg cgctacctgg ccatctgcag gcccaattga ctttaggttg tggatctcga cactgccatt ctccccgtgc tacggctggc gatactgtcc acgcagtgga ggcattgtgg ctgtaattgt acgtgcgtct cccacatcac ctacgcttct cggccaccta gtcttgtccc ccttcttcaa gctataaaaa aacacttggg taa <210> 3706 <211> 320 <212> PRT <213> Felis catus tgccgctcag gagttcatct ttttattcca ctgctcttca agtggtccag ctgaatgctc ctttctggag atctggtaca tgagaagaca atttccttaa catcagtgag gtttgtctct ccctcttcat tatcccacta ctgtgtttgt ggctttatca ttgtggctct aatcgcctgg ctgcacagac acacaagcca gattatcaca gccgtaatgc acgtattcgg tcagctgaag tgtctttttg cttttctttg ctccttattc tgggacacag ccccataatc tacagtctga tcaagctaaa atcttttttc tctctgcttt tttacacctt ccctccacac ccacagcgac atggttgcct tgacagctat tcatgacccc cacccctccc agcatatctt tcgtcatgat tcattttcat gccgccgcaa gcagtgtggc ccattgctct ggaacaaaga ataagaccga cccttattcc cattgtcatt acccatgtac cattccaaag cctgcagatg ggcctttgac caggctgtgt tgagattgcc ctgtgacttc tcgggtggtg gtcctatgtt ggccttttcc cctcatgtac ggcctttgca gatgaaggaa ggacctcaag

120

180

240

300

360

420

480

540

600

660

720

780

840

900

960

963 <400> 3706

Met Glu Ser Pro Asn Gln Ser Ala Ala Gln Glu 1 5 10

Phe Ile Phe Ser Ala 15

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Phe Pro Tyr Ser 20 Trp Gly Ser Ser Val Thr Cys Phe Ile Pro Leu Leu 25 30 Phe Ile Tyr Thr Phe Ile Val Ile Gly Asn Leu Val Ile Ile Ala Val 35 40 45 Val Gln Leu Asn Ala Pro Leu His Thr Pro Met Tyr Phe Phe Ile Gly 50 55 60 Thr Leu Ser Phe Leu Glu Ile Trp Tyr Thr Thr Ala Thr Ile Pro Lys 65 70 75 80 Met Leu Ala Ser Leu Leu Gly Glu Lys Thr Ile Ser Leu Asn Gly Cys 85 90 95 Leu Leu Gln Met Tyr Phe Phe His Ser Thr Gly Ile Ser Glu Val Cys 100 105 110 Leu Leu Thr Ala Met Ala Phe Asp Arg Tyr Leu Ala Ile Cys Ser Pro 115 120 125 Leu His Tyr Pro Thr Ile Met Thr Pro Arg Leu Cys Ala Gln Leu Thr 130 135 140 Leu Gly Cys Cys Val Cys Gly Phe Ile Thr Pro Leu Pro Glu Ile Ala 145 150 155 160 Trp Ile Ser Thr Leu Pro Phe Cys Gly Ser Asn Arg Leu Glu His Ile 165 170 175 Phe Cys Asp Phe Leu Pro Val Leu Arg Leu Ala Cys Thr Asp Thr Gln 180 185 190 Ala Ile Val Met Ile Arg Val Val Asp Thr Val His Ala Val Glu Ile 195 200 205 Ile Thr Ala Val Met Leu Ile Phe Met Ser Tyr Val Gly Ile Val Ala 210 215 220

Page 4153

Val 225 Ile Val Arg Ile Arg 230 Ser 069269_0225_SL.TXT Ala Glu Gly Arg Arg Lys 235 Ala Phe Ser 240 Thr Cys Val Ser His Ile Thr Val Phe Leu Leu Phe Phe Gly Ser Val 245 250 255 Ala Leu Met Tyr Leu Arg Phe Ser Ala Thr Tyr Ser Leu Phe Trp Asp 260 265 270 Thr Ala Ile Ala Leu Ala Phe Ala Val Leu Ser Pro Phe Phe Asn Pro 275 280 285 Ile Ile Tyr Ser Leu Arg Asn Lys Glu Met Lys Glu Ala Ile Lys Lys 290 295 300 His Leu Gly Gln Ala Lys Ile Phe Phe His Lys Thr Glu Asp Leu Lys 305 310 315 320

<210> 3707 <211> 942 <212> DNA <213> Felis catus <400> 3707

tcatcctgca cccaacaacc tcccttggaa ggcacttctc agggctgttt gcacagcccg 60 attccttaaa ctataaacaa tagggttgag gagaggggtc accacagtat aggtgaccgc 120 aatcagctga tcccgctcaa gagagtaact ggctttgggc ctcaagtaca tgaaggaggc 180 acagccatag tggatgatga ccactgtgag atgtgaggca caggtggaga aggccttctt 240 ccgcccctca gtggagggga tcctcaggat agctgccaga atgtaggcgt aggagatggt 300 gatgaaggag aaagagacca ggaggaccag caggctaagg atgaggatgc ccagctcact 360 cgggcctgtg tccccacaag ccaggctcag cactggcggc gtgtcacaga aaaagtgctg 420 gatctcgtgg gagccgcaga atgggaggtg gaaaatgacc agtgtcattc ccagcccaaa 480 gaggtaccca ctcaggaagg aggtgccaac cagccgggcg cagaaaggag gatccatgcg 540 gctggcatag tgcaacgggg cacagatggc cacatacctg tcaaagccca tgacggccag 600 gaggaagcag ttggtacagg cccacgaggc agagaagaac atctgagcag cacagccctc 660

Page 4154

069269_0225_SL.TXT ataggagatg gcctggcccc ccatgaccag gctggagagc atcttaggga tgatgcccaa 720 ggtgtagcag gtctcagaga aagacaggaa ggaaaggagg aggtacatgg gggtgtgcag 780 atggctgtcc agcctgatga ccacaataat gaagacattg ctggtcaggg ttaccagata 840 cagagagaag aagagtgcaa agagcaggag ctgaagctcc ccgaagccgg agaagcccag 900 gaagacaaag cccctccagg cggttgcatt ggtctgcccc at 942 <210> 3708 <211> 313 <212> PRT <213> Felis catus <400> 3708

Met Gly Gln Thr Asn Ala Thr Ala Trp Arg Gly Phe Val Phe Leu Gly 1 5 10 15

Phe Ser Gly Phe Gly Glu Leu Gln Leu Leu Leu Phe Ala Leu Phe Phe 20 25 30

Ser Leu Tyr Leu Val Thr Leu Thr Ser Asn Val Phe Ile Ile Val Val 35 40 45

Ile Arg Leu Asp Ser His Leu His Thr Pro Met Tyr Leu Leu Leu Ser 50 55 60

Phe Leu Ser Phe Ser Glu Thr Cys Tyr Thr Leu Gly Ile Ile Pro Lys 65 70 75 80

Met Leu Ser Ser Leu Val Met Gly Gly Gln Ala Ile Ser Tyr Glu Gly 85 90 95

Cys Ala Ala Gln Met Phe Phe Ser Ala Ser Trp Ala Cys Thr Asn Cys 100 105 110

Phe Leu Leu Ala Val Met Gly Phe Asp Arg Tyr Val Ala Ile Cys Ala 115 120 125

Pro Leu His Tyr Ala Ser Arg Met Asp Pro Pro Phe Cys Ala Arg Leu 130 135 140

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Val Gly Thr Ser Phe Leu Ser Gly Tyr Leu Phe Gly Leu Gly Met Thr 145 150 155 160 Leu Val Ile Phe His Leu Pro Phe Cys Gly Ser His Glu Ile Gln His 165 170 175 Phe Phe Cys Asp Thr Pro Pro Val Leu Ser Leu Ala Cys Gly Asp Thr 180 185 190 Gly Pro Ser Glu Leu Gly Ile Leu Ile Leu Ser Leu Leu Val Leu Leu 195 200 205 Val Ser Phe Ser Phe Ile Thr Ile Ser Tyr Ala Tyr Ile Leu Ala Ala 210 215 220 Ile Leu Arg Ile Pro Ser Thr Glu Gly Arg Lys Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Ile Ile His Tyr Gly Cys Ala Ser 245 250 255 Phe Met Tyr Leu Arg Pro Lys Ala Ser Tyr Ser Leu Glu Arg Asp Gln 260 265 270 Leu Ile Ala Val Thr Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Ile 275 280 285 Val Tyr Ser Leu Arg Asn Arg Ala Val Gln Thr Ala Leu Arg Ser Ala 290 295 300 Phe Gln Gly Arg Leu Leu Gly Ala Gly 305 310

<210> 3709 <211> 935 <212> DNA <213> Felis catus <400> 3709 acaatgaagg ccaaccagac agtgctgaaa gatttcattc ttgtgggctt ctcctcgtac

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ccacacatgc ggacattcct cttcgtgctc ttttttggcc tctaccttct caccctcaca 120 ggtaacctgg ccatcctggg tctaacttgg gcggacagat ctctccacac ccctatgtac 180 ctcttcctcc gtgccctctc tttctccgag acctgctaca cgctgaccat catccccaag 240 atgctggcag acctgctcac tgagaagaga agcatttcag tcccggggtg tggcttgcag 300 atgtgtttct tcctgggact tggtggcacc aactgcatca tcctcacact gatggggtac 360 gatcgctttc tggccatctg ccaccctctc cgatacccac tgctgatgac caatgtggtg 420 tgtgggcagc tggtggtctc tgcttgggcc ggaggcttcc ttatctctgt gacagagact 480 gcactgatat tcgggggctc cttctgcacc cccaacctca tccaccattt cttctgccac 540 atgcgggccg tggtgaggct gtcctgtcta gacagcgacc tcaccgaact ccttgtaaca 600 atgatctcgg tgtcaggctt gacgggcacc ttcctgttta tcgtcattac ttatgttttc 660 attctgtcca ctgtcttcag gatcccttca gccgagggca agcagaaggc cttttctacc 720 tgcgcctctc atctcactgt ggtcatcgtc cactttggct tcgcggctat tgtctatctg 780 aagccagaag gctcgggagg agatgacaca ctcatcgctg tcccttacac cgtcatcacc 840 cctttcctca gccccctcat tttcagcctc aggaatagag acatgaagaa tgcgttcaga 900 aagctgctgg caaagaggag tttctgaata cataa 935

<210> 3710 <211> 307 <212> PRT <213> Felis catus <400> 3710

Met Lys Ala Asn Gln Thr Val Leu Lys Asp Phe Ile Leu Val Gly Phe 1 5 10 15 Ser Ser Tyr Pro His Met Arg Thr Phe Leu Phe Val Leu Phe Phe Gly 20 25 30 Leu Tyr Leu Leu Thr Leu Thr Gly Asn Leu Ala Ile Leu Gly Leu Thr 35 40 45 Trp Ala Asp Arg Ser Leu His Thr Pro Met Tyr Leu Phe Leu Arg Ala

50 55 60

Page 4157

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Leu 65 Ser Phe Ser Glu Thr Cys Tyr Thr Leu Thr Ile Ile Pro Lys Met 70 75 80 Leu Ala Asp Leu Leu Thr Glu Lys Arg Ser Ile Ser Val Pro Gly Cys 85 90 95 Gly Leu Gln Met Cys Phe Phe Leu Gly Leu Gly Gly Thr Asn Cys Ile 100 105 110 Ile Leu Thr Leu Met Gly Tyr Asp Arg Phe Leu Ala Ile Cys His Pro 115 120 125 Leu Arg Tyr Pro Leu Leu Met Thr Asn Val Val Cys Gly Gln Leu Val 130 135 140 Val Ser Ala Trp Ala Gly Gly Phe Leu Ile Ser Val Thr Glu Thr Ala 145 150 155 160 Leu Ile Phe Gly Gly Ser Phe Cys Thr Pro Asn Leu Ile His His Phe 165 170 175 Phe Cys His Met Arg Ala Val Val Arg Leu Ser Cys Leu Asp Ser Asp 180 185 190 Leu Thr Glu Leu Leu Val Thr Met Ile Ser Val Ser Gly Leu Thr Gly 195 200 205 Thr Phe Leu Phe Ile Val Ile Thr Tyr Val Phe Ile Leu Ser Thr Val 210 215 220 Phe Arg Ile Pro Ser Ala Glu Gly Lys Gln Lys Ala Phe Ser Thr Cys 225 230 235 240 Ala Ser His Leu Thr Val Val Ile Val His Phe Gly Phe Ala Ala Ile 245 250 255 Val Tyr Leu Lys Pro Glu Gly Ser Gly Gly Asp Asp Thr Leu Ile Ala 260 265 270

Page 4158

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Val Pro Tyr Thr Val Ile Thr Pro Phe Leu Ser Pro Leu Ile Phe Ser 275 280 285 Leu Arg Asn Arg Asp Met Lys Asn Ala Phe Arg Lys Leu Leu Ala Lys 290 295 300 Arg Ser Phe

305 <210> 3711 <211> 955 <212> DNA <213> Felis catus <400> 3711

gatgggaaat tggagcagag gccacatagc agagttcgtg ttggtgggct tccctacctc 60 tccgcccctc cagtgcctcc tctttgtcct cttcctggca atttacctgt tgacattgtt 120 ggagaacgca ctcatcgttt ccacagtctg gctcacgcca agccttcacc gcccgatgta 180 ctttttcctt ggccatctct ccttcctgga gctgtggtac atcaatgtca cagttccccg 240 gcttttggga gcatttctta cccaggagcg tagagtctcc tacgtaggct gcatgactca 300 gctctacttc tttattgccc tagcctgcac cgaatgtgtc ctgctggcgg tcatggccta 360 tgaccgctac ctggccatct gtgagcccct ccgttatcct agtctcatgc catccagcct 420 ggccattcgc ctcgctgctt cctcttgggg tagtggcttc ttgagctcca tgatgaagct 480 tcttttcatt tcccggctgt cctactgtgg acccaacgtc atcaaccact ttttctgcga 540 tatctcccca ctactcaacc tcacctgctc tgacaaagag caagcagaac tagtagactt 600 cctcttggcc ctggtgatga ttctgctccc tctgttggcc gtggtttcat catatgctgc 660 cataatggct gccatcctca ggattcctac tgcccaggga cgtcgcaaag ccttctccac 720 ctgtgcctct cacctggcag tggttgttat ctactactcc tccaccctct tcacctatgc 780 acggccccag gccatgtaca ccttcaacca taacaaggtc atctctgtgc tctatacagt 840 cattgtaccg ttcctcaatc cagccatcta ctgcctgagg aacaaggagg tgaaggatgc 900 tctcaggaag tcagtcctgg gcagatgcca ctatccgagg gacgtcccag attga 955

Page 4159

069269_0225_SL.TXT <210> 3712 <211> 317 <212> PRT <213> Felis catus

<400> 3712 Met 1 Gly Asn Trp Ser Arg 5 Gly His Ile Ala 10 Glu Phe Val Leu Val 15 Gly Phe Pro Thr Ser Pro Pro Leu Gln Cys Leu Leu Phe Val Leu Phe Leu 20 25 30 Ala Ile Tyr Leu Leu Thr Leu Leu Glu Asn Ala Leu Ile Val Ser Thr 35 40 45 Val Trp Leu Thr Pro Ser Leu His Arg Pro Met Tyr Phe Phe Leu Gly 50 55 60 His Leu Ser Phe Leu Glu Leu Trp Tyr Ile Asn Val Thr Val Pro Arg 65 70 75 80 Leu Leu Gly Ala Phe Leu Thr Gln Glu Arg Arg Val Ser Tyr Val Gly 85 90 95 Cys Met Thr Gln Leu Tyr Phe Phe Ile Ala Leu Ala Cys Thr Glu Cys 100 105 110 Val Leu Leu Ala Val Met Ala Tyr Asp Arg Tyr Leu Ala Ile Cys Glu 115 120 125 Pro Leu Arg Tyr Pro Ser Leu Met Pro Ser Ser Leu Ala Ile Arg Leu 130 135 140 Ala Ala Ser Ser Trp Gly Ser Gly Phe Leu Ser Ser Met Met Lys Leu 145 150 155 160 Leu Phe Ile Ser Arg Leu Ser Tyr Cys Gly Pro Asn Val Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Leu Leu Asn Leu Thr Cys Ser Asp Lys

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180

069269_0225_SL.TXT 185 190

Glu Gln Ala Glu Leu Val Asp Phe Leu Leu Ala Leu Val Met Ile Leu 195 200 205 Leu Pro Leu Leu Ala Val Val Ser Ser Tyr Ala Ala Ile Met Ala Ala 210 215 220 Ile Leu Arg Ile Pro Thr Ala Gln Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ala Val Val Val Ile Tyr Tyr Ser Ser Thr Leu 245 250 255 Phe Thr Tyr Ala Arg Pro Gln Ala Met Tyr Thr Phe Asn His Asn Lys 260 265 270 Val Ile Ser Val Leu Tyr Thr Val Ile Val Pro Phe Leu Asn Pro Ala 275 280 285 Ile Tyr Cys Leu Arg Asn Lys Glu Val Lys Asp Ala Leu Arg Lys Ser 290 295 300 Val Leu Gly Arg Cys His Tyr Pro Arg Asp Val Pro Asp

305 310 315 <210> 3713 <211> 701 <212> DNA <213> Felis catus <400> 3713

atgatcccca aagttctgga agcaggtaac cacacggcaa ccatacactt cgttcttctg 60 ggatttccaa cacggccagc cttccagctt ctcctcttct tcgtgttcct ggcaacctac 120 ctgctgactc tgctggagaa cgctctcatc atcctggccc ttcgcggtga cagacaactg 180 cacaagccca tgtacgtctt tctgagccac ctctccttcc tggagatgtg gtatgtcacc 240 gtcatcagcc ccaagatgct ggtggacttc ctcagccatg acaagaccat ttccttcaat 300 ggctgcatga ctcaactgta cttctttgtg acctttgtct gcgcagagta cctcctcctc 360

Page 4161

069269_0225_SL.TXT gctgcgatgg cctttgaccg ccacgtggcc atttgtaatc cactacgcta cccagttatc gtgaccaacc agctctgtgg taccctggcg gcgggatgct ggctctgtgg gctcacaact gccacgatta agatggtttt catagcccga ctccactact gtggcaaacc tcacatcaac cattatttct gcgatatttc tccgctcctc agcatcccct gcgaagactc ctcgcaggcg gagcgagtgg acttctttct ggccctcgtg gttattgccg tccccctttg tgcggtggtg gcgtcttatg ccaccattgt cagtgccatc cttaggatcc c

420

480

540

600

660

701 <210> 3714 <211> 234 <212> PRT <213> Felis catus

<400> 3714 Leu Glu Ala Gly Asn His Thr Ala Thr Ile His Met 1 Ile Pro Lys Val 5 10 15 Phe Val Leu Leu Gly Phe Pro Thr Arg Pro Ala Phe Gln Leu Leu Leu 20 25 30 Phe Phe Val Phe Leu Ala Thr Tyr Leu Leu Thr Leu Leu Glu Asn Ala 35 40 45 Leu Ile Ile Leu Ala Leu Arg Gly Asp Arg Gln Leu His Lys Pro Met 50 55 60 Tyr Val Phe Leu Ser His Leu Ser Phe Leu Glu Met Trp Tyr Val Thr 65 70 75 80 Val Ile Ser Pro Lys Met Leu Val Asp Phe Leu Ser His Asp Lys Thr 85 90 95 Ile Ser Phe Asn Gly Cys Met Thr Gln Leu Tyr Phe Phe Val Thr Phe 100 105 110 Val Cys Ala Glu Tyr Leu Leu Leu Ala Ala Met Ala Phe Asp Arg His 115 120 125

Page 4162

Val Ala 130 Ile Cys Asn Pro Leu 135 069269_0225_SL.TXT Arg Tyr Pro Val Ile Val 140 Thr Asn Gln Leu Cys Gly Thr Leu Ala Ala Gly Cys Trp Leu Cys Gly Leu Thr Thr 145 150 155 160 Ala Thr Ile Lys Met Val Phe Ile Ala Arg Leu His Tyr Cys Gly Lys 165 170 175 Pro His Ile Asn His Tyr Phe Cys Asp Ile Ser Pro Leu Leu Ser Ile 180 185 190 Pro Cys Glu Asp Ser Ser Gln Ala Glu Arg Val Asp Phe Phe Leu Ala 195 200 205 Leu Val Val Ile Ala Val Pro Leu Cys Ala Val Val Ala Ser Tyr Ala 210 215 220 Thr Ile Val Ser Ala Ile Leu Arg Ile Pro

225 230

<210> 3715 <211> 733 <212> DNA <213> Felis catus <400> 3715 ttcgttcttc tgggatttcc aacacggcca gccttccagc ttctcctctt cttcgtgttc 60 ctggcaacct acctgctgac tctgctggag aacgctctca tcatcctggc ccttcgcggt 120 gacagacaac tgcacaagcc catgtacgtc tttctgagcc acctctcctt cctggagatg 180 tggtatgtca ccgtcatcag ccccaagatg ctggtggact tcctcagcca tgacaagacc 240 atttccttca atggctgcat gactcaactg tacttctttg tgacctttgt ctgcgcagag 300 tacctcctcc tcgctgcgat ggcctttgac cgccacgtgg ccatttgtaa tccactacgc 360 tacccagtta tcgtgaccaa ccagctctgt ggtaccctgg cggcgggatg ctggctctgt 420 gggctcacaa ctgccacgat taagatggtt ttcatagccc gactccacta ctgtggcaaa 480 cctcacatca accattattt ctgcgatatt tctccgctcc tcagcatccc ctgcgaagac 540

Page 4163

069269_0225_SL.TXT tcctcgcagg cggagcgagt ggacttcttt ctggccctcg tggttattgc cgtccccctt tgtgcggtgg tggcgtctta tgccaccatt gtcagtgcca tccttaggat cccttcttca caaggccgcc aaaaggcgtt ttccacctgt gcctctcacc tgactgttgt aattctcttc tattccacaa ccc

600

660

720

733 <210> 3716 <211> 245 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (245)..(245) <223> Any amino acid <400> 3716

Phe Val Leu Leu Gly Phe Pro Thr Arg Pro Ala Phe Gln Leu Leu Leu 1 5 10 15 Phe Phe Val Phe Leu Ala Thr Tyr Leu Leu Thr Leu Leu Glu Asn Ala 20 25 30 Leu Ile Ile Leu Ala Leu Arg Gly Asp Arg Gln Leu His Lys Pro Met 35 40 45 Tyr Val Phe Leu Ser His Leu Ser Phe Leu Glu Met Trp Tyr Val Thr 50 55 60 Val Ile Ser Pro Lys Met Leu Val Asp Phe Leu Ser His Asp Lys Thr 65 70 75 80 Ile Ser Phe Asn Gly Cys Met Thr Gln Leu Tyr Phe Phe Val Thr Phe 85 90 95 Val Cys Ala Glu Tyr Leu Leu Leu Ala Ala Met Ala Phe Asp Arg His 100 105 110 Val Ala Ile Cys Asn Pro Leu Arg Tyr Pro Val Ile Val Thr Asn Gln 115 120 125

Page 4164

069269_0225_SL.TXT

Leu Cys Gly Thr Leu Ala Ala Gly Cys Trp Leu Cys Gly Leu Thr Thr 130 135 140 Ala Thr Ile Lys Met Val Phe Ile Ala Arg Leu His Tyr Cys Gly Lys 145 150 155 160 Pro His Ile Asn His Tyr Phe Cys Asp Ile Ser Pro Leu Leu Ser Ile 165 170 175 Pro Cys Glu Asp Ser Ser Gln Ala Glu Arg Val Asp Phe Phe Leu Ala 180 185 190 Leu Val Val Ile Ala Val Pro Leu Cys Ala Val Val Ala Ser Tyr Ala 195 200 205 Thr Ile Val Ser Ala Ile Leu Arg Ile Pro Ser Ser Gln Gly Arg Gln 210 215 220 Lys Ala Phe Ser Thr Cys Ala Ser His Leu Thr Val Val Ile Leu Phe 225 230 235 240 Tyr Ser Thr Thr Xaa

245 <210> 3717 <211> 924 <212> DNA <213> Felis catus <400> 3717

agctttagga taaaattctc ttctgccaat cactttccaa atggccatct tgatagcctt 60 gtttctgagg ctctacacca cggggttcaa cagcggagtc acaactgtgt aggtcactgt 120 cacaagcctg tcttcgctgg atgagaactt ggctgagggc tgcaggtaga cagaggaggc 180 acggccatgg tggacgatga ccacagtgag gtgggaggca caggtgggga gggcttcccg 240 cttgctgtca gtggatggga tcttcaagat ggtgtggaca atgaagccat acgagatgca 300 gaaaaaagtc agggagatca tgagtgttgg gaccccacca atgaagatga tcagctcatg 360 gatgtaggtt tcagtacatg caagttggat aactgacaag atgtcgcaga accagtggtt 420

Page 4165

069269_0225_SL.TXT

gatcttattg gggccacata aagggagttc aaagactaag agggagccta tcagtgagaa 480 caaaagccaa tcacagcaca agtggccacc agctgtctgc atatctgcca gctcatgagg 540 atagggtacc gaagtggatg acagatggca gcatagtggt cataacccat gacccccagc 600 agcatgcaat tagtgacagc aaaaccaaag aaggaaagca tccgagtggc accgtcgaca 660 aatgaggttg ttctgagcag ggacaacaga tttatgagca tcttgggcag gatgaccaga 720 gtgtagcatg tctcagagat gggaaggatc cccaggaaga agcacatagg tacgtggagg 780 ctgcgagcca ggcatacgac cgtgacaatg gtgatgttcc cactgagaac gatcagatac 840 aggcacagaa atacagcaaa gaggatgagc tttggatttc tccgaggttg gagaagccca 900 gcagcaacct ctgtgacaga ggag 924

<210> 3718 <211> 150 <212> PRT <213> Felis catus

<400> 3718 Val Ala Ala Gly Leu Leu Gln Pro Arg Arg Asn Ser Ser 1 Val Thr Glu 5 10 15 Pro Lys Leu Ile Leu Phe Ala Val Phe Leu Cys Leu Tyr Leu Ile Val 20 25 30 Leu Ser Gly Asn Ile Thr Ile Val Thr Val Val Cys Leu Ala Arg Ser 35 40 45 Leu His Val Pro Met Cys Phe Phe Leu Gly Ile Leu Pro Ile Ser Glu 50 55 60 Thr Cys Tyr Thr Leu Val Ile Leu Pro Lys Met Leu Ile Asn Leu Leu 65 70 75 80 Ser Leu Leu Arg Thr Thr Ser Phe Val Asp Gly Ala Thr Arg Met Leu 85 90 95 Ser Phe Phe Gly Phe Ala Val Thr Asn Cys Met Leu Leu Gly Val Met 100 105 110

Page 4166

069269_0225_SL.TXT

Gly Tyr Asp His Tyr Ala Ala Ile Cys His Pro Leu Arg Tyr Pro Ile 115 120 125 Leu Met Ser Trp Gln Ile Cys Arg Gln Leu Val Ala Thr Cys Ala Val 130 135 140 Ile Gly Phe Cys Ser His 145 150

<210> 3719 <211> 942 <212> DNA <213> Felis catus <400> 3719

tataaagtct taagagaaaa ccccgtcttt gtgatcattt cccgaatggc cagctgcaca 60 cctctgttcc taaggctgta caccataggg ttcaactgtg gggtgacgat ggtgtaggtc 120 gctgtcactg gtctgtcttt gcctgatgag tatttggctg agggccgcag gtagacagag 180 gaggcacagc catggtggac gatgaccaca gtgaggtggg aggcacaggt ggggagggct 240 ttccgcttgc cgtcagccga cgggatcttc aggatggtgt ggacaacgaa gccgtaagag 300 gtgcggaaga agagcaaggg tacaactagc accaaggcgc cacagatgaa gaagaccagc 360 tcattggtgt acgtttcagc acaggcaagt cggatgactg gtgagatgtc gcaaaagtag 420 tagttgacct tgttggagcc acagagaggg aggctgaaga ccaaagttgt tcccaccaga 480 gatactagga agccactaac aatacagatt cctgcccgct gggcacatac cctccagttc 540 acaagaaccg ggtagcgcaa aggctggcag atggcggcat agcggtcata acccgtaact 600 cccagaagca ggcagttggt gacagcaaag ccaaggaaga agaacatctg ggtggtacag 660 cccacgaagg agagtgtcct gaggacagag agcaggttga taagcatcct gggcagggta 720 acaatggtgt agaagacctc cgaggttgaa aggacacaga ggaaaaaagg acatgggggt 780 gtggaggctg cggtccagcc ggatgacgga caagagggtg cggttcccac tcgggatgat 840 caaattagag gccgagaaag aggacaaaca ggacaggctg aaattcgcca agtctggaga 900 aacccagcag caggaattca gtgacccggg aggaattggc ca 942

Page 4167

069269_0225_SL.TXT <210> 3720 <211> 236 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (236)..(236) <223> Any amino acid

<400> 3720 Met 1 Leu Ile Asn Leu Leu 5 Ser Val Leu Arg Thr Leu Ser Phe Val Gly 10 15 Cys Thr Thr Gln Met Phe Phe Phe Leu Gly Phe Ala Val Thr Asn Cys 20 25 30 Leu Leu Leu Gly Val Thr Gly Tyr Asp Arg Tyr Ala Ala Ile Cys Gln 35 40 45 Pro Leu Arg Tyr Pro Val Leu Val Asn Trp Arg Val Cys Ala Gln Arg 50 55 60 Ala Gly Ile Cys Ile Val Ser Gly Phe Leu Val Ser Leu Val Gly Thr 65 70 75 80 Thr Leu Val Phe Ser Leu Pro Leu Cys Gly Ser Asn Lys Val Asn Tyr 85 90 95 Tyr Phe Cys Asp Ile Ser Pro Val Ile Arg Leu Ala Cys Ala Glu Thr 100 105 110 Tyr Thr Asn Glu Leu Val Phe Phe Ile Cys Gly Ala Leu Val Leu Val 115 120 125 Val Pro Leu Leu Phe Phe Arg Thr Ser Tyr Gly Phe Val Val His Thr 130 135 140 Ile Leu Lys Ile Pro Ser Ala Asp Gly Lys Arg Lys Ala Leu Pro Thr 145 150 155 160

Page 4168

069269_0225_SL.TXT

Cys Ala Ser His Leu Thr 165 Val Val Ile Val His His Gly Cys Ala Ser 170 175 Ser Val Tyr Leu Arg Pro Ser Ala Lys Tyr Ser Ser Gly Lys Asp Arg 180 185 190 Pro Val Thr Ala Thr Tyr Thr Ile Val Thr Pro Gln Leu Asn Pro Met 195 200 205 Val Tyr Ser Leu Arg Asn Arg Gly Val Gln Leu Ala Ile Arg Glu Met 210 215 220 Ile Thr Lys Thr Gly Phe Ser Leu Lys Thr Leu Xaa 225 230 235

<210> 3721 <211> 933 <212> DNA <213> Felis catus <400> 3721

aggatatgaa gtatggccca ttacccttcg aagggctgac ttgaactcct gatttctcag 60 actgtaaatc attggattga acagcggagt caggatggtg taggacacag atatgagggt 120 gtcttgactt gaggagtagc tggacttggg ccttaagtag atgaaagagg cacaaccata 180 atgaacagtt accacgatga gatgagaggc acaggtggag aaagccttgt acctgccggt 240 ggaggatggg atcttcagaa tggcggaaat gatacgaatg taggagatca ggataagtag 300 caggggaatg accaagacaa acacaccaat catgaatatg accaactggc tgaggcgtga 360 gtggtgcgat gccaccgcga ggacaggggc gatgtcacaa aagtagtgac ggagctggtt 420 ggaggcgcgg aagggcaggt ggaataccat ggacgtgata atctgtgcaa tagtaaagcc 480 acaggcacag gcagcagcca cgagtcccac acacaccccg tgtcccatga gctccgtgta 540 gcgcagaggg ttacagatgg ccacgtagcg gtcatacccc atggccgcca gcaggaagga 600 gtgagagcag ccgaggaaga ggaaggtgaa catctggatg gcacagccca ggaaggagat 660 ggtcttcttc tgggccagga ggtcaaccag catcttgggt acgatgacga aggtgtagca 720 ggtctcagag caggagagga cggcgaggaa gaagtacatg ggggcatgaa gggctctgtc 780

Page 4169

069269_0225_SL.TXT tagcacgatg gtggaaacga tgatggcatt ggtgcccaga gtgaacaggt agaggggcag gaaggcaaca aagagtagcc gctgcagccc ggccagagaa gagaagccga ggaagacgaa ctctgtcacc agggtcccgt tgccccgctc cat

840

900

933 <210> 3722 <211> 311 <212> PRT <213> Felis catus

<400> 3722 Gly Thr Leu Val Thr Glu Phe Val Phe Leu Gly Met Glu 1 Arg Gly Asn 5 10 15 Phe Ser Ser Leu Ala Gly Leu Gln Arg Leu Leu Phe Val Ala Phe Leu 20 25 30 Pro Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Val Ser Thr 35 40 45 Ile Val Leu Asp Arg Ala Leu His Ala Pro Met Tyr Phe Phe Leu Ala 50 55 60 Val Leu Ser Cys Ser Glu Thr Cys Tyr Thr Phe Val Ile Val Pro Lys 65 70 75 80 Met Leu Val Asp Leu Leu Ala Gln Lys Lys Thr Ile Ser Phe Leu Gly 85 90 95 Cys Ala Ile Gln Met Phe Thr Phe Leu Phe Leu Gly Cys Ser His Ser 100 105 110 Phe Leu Leu Ala Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Thr Glu Leu Met Gly His Gly Val Cys Val Gly Leu 130 135 140 Val Ala Ala Ala Cys Ala Cys Gly Phe Thr Ile Ala Gln Ile Ile Thr 145 150 155 160

Page 4170

069269_0225_SL.TXT

Ser Met Val Phe His 165 Leu Pro Phe Arg Ala 170 Ser Asn Gln Leu Arg 175 His Tyr Phe Cys Asp Ile Ala Pro Val Leu Ala Val Ala Ser His His Ser 180 185 190 Arg Leu Ser Gln Leu Val Ile Phe Met Ile Gly Val Phe Val Leu Val 195 200 205 Ile Pro Leu Leu Leu Ile Leu Ile Ser Tyr Ile Arg Ile Ile Ser Ala 210 215 220 Ile Leu Lys Ile Pro Ser Ser Thr Gly Arg Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ile Val Val Thr Val His Tyr Gly Cys Ala Ser 245 250 255 Phe Ile Tyr Leu Arg Pro Lys Ser Ser Tyr Ser Ser Ser Gln Asp Thr 260 265 270 Leu Ile Ser Val Ser Tyr Thr Ile Leu Thr Pro Leu Phe Asn Pro Met 275 280 285 Ile Tyr Ser Leu Arg Asn Gln Glu Phe Lys Ser Ala Leu Arg Arg Val 290 295 300 Met Gly His Thr Ser Tyr Pro

305 310 <210> 3723 <211> 945 <212> DNA <213> Felis catus <400> 3723 atgaagagac agaaccagag catgaccact gagttcatcc tcgtaggctt ctcaaatcag gggaatctgc agatacttct cttcttcgtc ttcctcctgg tttacctgac cactctgatg

120

Page 4171

069269_0225_SL.TXT

gccaatgcca ccatcatgat cgtcattcgt ctggacagga ctctgcacac cccaatgtac 180 ttctttctct ttgtcctctc ctgctctgaa acctgctaca ccttggtcat tgtaccaaaa 240 atgctgacca acctgctttc cgcaagccag actatttctt tctccggatg tgctgctcag 300 ctctacttct tcgtgggctt tgcctgtacc aactgttttc taattgctgt catgggctat 360 gatcgctacg ttgccatctg caaccctctc aactacgcac tggttgtcgg ccgagccacc 420 tgcgttcagc tggtcctcgc ctccggcttc tgtggcttcc tcatctctgc ggtggtcaat 480 gccttggtgt ttagcgtgcc tttctgtgcc tcccatcgga tcaaccactt tttctgtgac 540 atttccccgg tcataaaact aggctgcacg gacaccaaca gaaaggagat ggtcatcttc 600 ttcctcagta ttctggtatt gctggtgccc tctgtgctga tcttcatctc ctacgtcctg 660 atcgtctcca ccatcctcaa gatagcctcg gctgagggcc ggaagaagac ctttgccacc 720 tgcgcctccc acctcacggt ggtcgtcgtc cactacggct gcgcctcctt tatctacctg 780 aggcccacgt ccctgtactc ctcagataag gaccggcttg tggcagtgac ctacactgtg 840 atcaccccac tgctcaatcc tcttgtgtac gcactgagaa ataaagaagt aaaggtgtct 900 ctgagtaaag ttctcagcag gtactcattt cccaaaactg tatga 945

<210> 3724 <211> 314 <212> PRT <213> Felis catus

<400> 3724 Asn 5 Gln Ser Met Thr Thr Glu Phe Ile Leu Val Gly Met 1 Lys Arg Gln 10 15 Phe Ser Asn Gln Gly Asn Leu Gln Ile Leu Leu Phe Phe Val Phe Leu 20 25 30 Leu Val Tyr Leu Thr Thr Leu Met Ala Asn Ala Thr Ile Met Ile Val 35 40 45 Ile Arg Leu Asp Arg Thr Leu His Thr Pro Met Tyr Phe Phe Leu Phe 50 55 60 Val Leu Ser Cys Ser Glu Thr Cys Tyr Thr Leu Val Ile Val Pro Lys Page 4172

069269_0225_SL.TXT

Met Leu Thr Asn Leu Leu Ser Ala Ser Gln Thr Ile Ser Phe Ser Gly 85 90 95 Cys Ala Ala Gln Leu Tyr Phe Phe Val Gly Phe Ala Cys Thr Asn Cys 100 105 110 Phe Leu Ile Ala Val Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Asn Tyr Ala Leu Val Val Gly Arg Ala Thr Cys Val Gln Leu 130 135 140 Val Leu Ala Ser Gly Phe Cys Gly Phe Leu Ile Ser Ala Val Val Asn 145 150 155 160 Ala Leu Val Phe Ser Val Pro Phe Cys Ala Ser His Arg Ile Asn His 165 170 175 Phe Phe Cys Asp Ile Ser Pro Val Ile Lys Leu Gly Cys Thr Asp Thr 180 185 190 Asn Arg Lys Glu Met Val Ile Phe Phe Leu Ser Ile Leu Val Leu Leu 195 200 205 Val Pro Ser Val Leu Ile Phe Ile Ser Tyr Val Leu Ile Val Ser Thr 210 215 220 Ile Leu Lys Ile Ala Ser Ala Glu Gly Arg Lys Lys Thr Phe Ala Thr 225 230 235 240 Cys Ala Ser His Leu Thr Val Val Val Val His Tyr Gly Cys Ala Ser 245 250 255 Phe Ile Tyr Leu Arg Pro Thr Ser Leu Tyr Ser Ser Asp Lys Asp Arg 260 265 270 Leu Val Ala Val Thr Tyr Thr Val Ile Thr Pro Leu Leu Asn Pro Leu

Page 4173

06926 i9_0225_S iL.TX T 275 280 285 Val Tyr Ala Leu Arg Asn Lys Glu Val Lys Val Ser Leu Ser Lys Val 290 295 300 Leu Ser Arg Tyr Ser Phe Pro Lys Thr Val 305 310

<210> 3725 <211> 945 <212> DNA <213> Felis catus <400> 3725

atggagtggg gcaacgggac cctggtgaca gagttcgtct tcctcggctt ctcttctctg 60 gccgggctgc agcggctgct ctttgttgcc ttcctgcccc tctacttgtt cactctgggc 120 accaatgcca tcattgtttc caccatcgtg ctagacagag cccttcacgc ccccatgtac 180 ttcttcctcg ctgtcctctc ctgctctgag acctgctaca ccttcgtcat catacccaag 240 atgctggttg acctcctggc ccagaagaag accatctcct tcctgggctg tgccatccag 300 atgttcacct tcctcttcct cggctgctct cactccttcc tgctggcggc catggggtat 360 gaccgctacg tggccatctg taaccctctg cgctacacgg tgctcatggg acacagggtg 420 tgtgtgggac tcgtggctgc tgcctgtgcc tgtggcttta ctattgcaca gattatcacc 480 tccgtggtat tccacctgcc cttctgcgcc tccaaccagc tccatcattt cttctgtgac 540 atcgcccctg tcctcacagt ggcatctcat catacctacc tgagtcagat tgtcatcgtc 600 atgctctgtg cactggtcct ggttatcccc ctgtcactga ttttggtgtc ctatattcac 660 atcatctctg ccatactcca gtttccttcc acattgggca ggtacaaagc cttctccacc 720 tgtgcgtccc acctcattgt tgtcaccatc cattatggct gtgcctcctt tatctactta 780 cggctcaagt ccaactactc ctcaagccga gatgctctca tatcagtctc ctacaccatc 840 ctgactccct tgttcaatcc actgatttac agcttgagaa ataaggagtt caagtcagct 900 cttcgtagag ctgcgggaaa aaccatttcc ctgccacgat gttaa 945

<210> 3726 <211> 314

Page 4174

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 3726 Leu 15 Gly Met 1 Glu Trp Gly Asn Gly Thr Leu 5 Val Thr 10 Glu Phe Val Phe Phe Ser Ser Leu Ala Gly Leu Gln Arg Leu Leu Phe Val Ala Phe Leu 20 25 30 Pro Leu Tyr Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Val Ser Thr 35 40 45 Ile Val Leu Asp Arg Ala Leu His Ala Pro Met Tyr Phe Phe Leu Ala 50 55 60 Val Leu Ser Cys Ser Glu Thr Cys Tyr Thr Phe Val Ile Ile Pro Lys 65 70 75 80 Met Leu Val Asp Leu Leu Ala Gln Lys Lys Thr Ile Ser Phe Leu Gly 85 90 95 Cys Ala Ile Gln Met Phe Thr Phe Leu Phe Leu Gly Cys Ser His Ser 100 105 110 Phe Leu Leu Ala Ala Met Gly Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Thr Val Leu Met Gly His Arg Val Cys Val Gly Leu 130 135 140 Val Ala Ala Ala Cys Ala Cys Gly Phe Thr Ile Ala Gln Ile Ile Thr 145 150 155 160 Ser Val Val Phe His Leu Pro Phe Cys Ala Ser Asn Gln Leu His His 165 170 175 Phe Phe Cys Asp Ile Ala Pro Val Leu Thr Val Ala Ser His His Thr 180 185 190

Page 4175

Tyr Leu Ser 195 Gln Ile Val Ile 069269_0225_SL.TXT Val Leu Val Val Met 200 Leu Cys Ala Leu 205 Ile Pro Leu Ser Leu Ile Leu Val Ser Tyr Ile His Ile Ile Ser Ala 210 215 220 Ile Leu Gln Phe Pro Ser Thr Leu Gly Arg Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ile Val Val Thr Ile His Tyr Gly Cys Ala Ser 245 250 255 Phe Ile Tyr Leu Arg Leu Lys Ser Asn Tyr Ser Ser Ser Arg Asp Ala 260 265 270 Leu Ile Ser Val Ser Tyr Thr Ile Leu Thr Pro Leu Phe Asn Pro Leu 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Glu Phe Lys Ser Ala Leu Arg Arg Ala 290 295 300 Ala Gly Lys Thr Ile Ser Leu Pro Arg Cys 305 310

<210> 3727 <211> 925 <212> DNA <213> Felis catus <400> 3727

ttcaacagga ccaccgtggt tacccagttc accctggtgg gcttctctag cctgggggca 60 ctccaactgc tgccgtctgt cctctttctt ctcctctacg tgaccatcct gctggccgat 120 gccaccacca tgactgtcat ccgctgcagc aggactctac accctcccac gtatgggttc 180 ctgttcatcc tttccttctc cgaatcctgc gacactcttg gcatcatccc tcagctgctg 240 gcccacctgc tcccagccac caagggcatc tcctctgtgg cctgtgccac gcagctcttc 300 ttccttggct ttgcctgcac caattgcttt ctcatccctg tgatggggta cgatcgttag 360 gtggcgattt gccactctat gagctacacg ctcatcatga acaagagggt agggttgggg 420

Page 4176

069269_0225_SL.TXT

ttggtttccc tgtccggagt cacaggcttc ttcattgctt tgctggccac caaactcgtc 480 tgtggcatga ctttctgtgg tcccaacaga gtcaaccgct atttctgtga tatggcgtcc 540 gtcactaagt tggcctgtgc agacacccat gtgaaagaac cggctccatt cagccgaagc 600 attctggcga tcatggcgcc tttcctgctg attctgatct cctgtggctt catcgttaac 660 accatcctga agatcccctg ggctgagggg aagagaaggc ctttgcccca cctcgcggta 720 gtcttcgtgc actacggctg tgcctccatc acctacctga ggcccagatc aaagtctgcc 780 tcagacaagg atcagttggt ggcagtgacc tacactgtgg tcactcccct gctcaatcct 840 ctggtctaca gtctgaggaa tcaggaggtg aagtctgccc cgaaaagatt tttgggaaag 900 ccctggagcc gccaaggtga tctaa 925

<210> 3728 <211> 183 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (183)..(183) <223> Any amino acid <400> 3728

Met Ser Tyr Thr Leu Ile Met Asn Lys Arg Val Gly Leu Gly Leu Val 1 5 10 15

Ser Leu Ser Gly Val Thr Gly Phe Phe Ile Ala Leu Leu Ala Thr Lys 20 25 30

Leu Val Cys Gly Met Thr Phe Cys Gly Pro Asn Arg Val Asn Arg Tyr 35 40 45

Phe Cys Asp Met Ala Ser Val Thr Lys Leu Ala Cys Ala Asp Thr His 50 55 60

Val Lys Glu Pro Ala Pro Phe Ser Arg Ser Ile Leu Ala Ile Met Ala 65 70 75 80

Pro Phe Leu Leu Ile Leu Ile Ser Cys Gly Phe Ile Val Asn Thr Ile Page 4177

069269_0225_SL.TXT

Leu Lys Ile Pro Trp Ala Glu Gly Lys Arg Arg Pro Leu Pro His Leu 100 105 110 Ala Val Val Phe Val His Tyr Gly Cys Ala Ser Ile Thr Tyr Leu Arg 115 120 125 Pro Arg Ser Lys Ser Ala Ser Asp Lys Asp Gln Leu Val Ala Val Thr 130 135 140 Tyr Thr Val Val Thr Pro Leu Leu Asn Pro Leu Val Tyr Ser Leu Arg 145 150 155 160 Asn Gln Glu Val Lys Ser Ala Pro Lys Arg Phe Leu Gly Lys Pro Trp 165 170 175 Ser Arg Gln Gly Asp Leu Xaa 180

<210> 3729 <211> 942 <212> DNA <213> Felis catus <400> 3729

tcagttttgt ttagcgaacc atctctggat cctgctacgt atttgttggg ttttgacact 60 gtagatgata gggttcatca agggtgggaa aaggatatag atattgccca tgaggacatg 120 gaccacagga gagaggtgct ttccaaagcg gtgcaccata gtcaacccaa taattgggat 180 atagaaaacc agaacagcac agatgtggga gacacaggtc ttcaaggact tgagccgctc 240 gtcccgggat gcaatagtca agactgaatg caggatcgcg atgtaggaga tgagaatgag 300 caccgaatcc aaaaagagtg tgcagatcac cagggctaac gcatagaagc tgttgaagcg 360 gatgtcggag caggcgagcc gaagtaagtc ttggtgcagg cagaaggaat gggagaggat 420 atgaggatgg cagtaatcga agaactttag gcggacaatg ggagcggtaa tgaacaggaa 480 actcctccct aaaatggcca caccaatggt gatgattctc atattggtga ggatggatgt 540 atatctcaga ggattgcaga tggcagtaaa gcgatcaaag gccatggcaa gaaggactcc 600

Page 4178

069269_0225_SL.TXT agactccatg catgatagac catgaacaaa gaaggtttga gcaatgcagg catcgagacc aatctcttgg ctgatccccc acaggatccc gagcaccgtg tgcactgtgg acagccccat gcacaggtca gtgagggcca acatggccag gaagtagaac atgggctcat gtaggctggg ctcggtccgg atcacatgca acaccaggca attccctaag agtaccatag catagataca ggagaaagga atggagagcc aaggatattc ccgttccagg ccagggaaac ccgtaaggag aaaggtggag ttactgattt tggaatcagg ttgaacagac at

660

720

780

840

900

942 <210> 3730 <211> 313 <212> PRT <213> Felis catus <400> 3730

Met Ser Val Gln Pro Asp Ser Lys Ile Ser Asn Ser Thr Phe Leu Leu 1 5 10 15 Thr Gly Phe Pro Gly Leu Glu Arg Glu Tyr Pro Trp Leu Ser Ile Pro 20 25 30 Phe Ser Cys Ile Tyr Ala Met Val Leu Leu Gly Asn Cys Leu Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Glu Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Val 65 70 75 80 His Thr Val Leu Gly Ile Leu Trp Gly Ile Ser Gln Glu Ile Gly Leu 85 90 95 Asp Ala Cys Ile Ala Gln Thr Phe Phe Val His Gly Leu Ser Cys Met 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Phe Asp Arg Phe Thr Ala Ile 115 120 125

Page 4179

Cys Asn 130 Pro Leu Arg Tyr Thr 135 069269_0225_SL.TXT Ser Ile Leu Thr Asn Met 140 Arg Ile Ile Thr Ile Gly Val Ala Ile Leu Gly Arg Ser Phe Leu Phe Ile Thr Ala 145 150 155 160 Pro Ile Val Arg Leu Lys Phe Phe Asp Tyr Cys His Pro His Ile Leu 165 170 175 Ser His Ser Phe Cys Leu His Gln Asp Leu Leu Arg Leu Ala Cys Ser 180 185 190 Asp Ile Arg Phe Asn Ser Phe Tyr Ala Leu Ala Leu Val Ile Cys Thr 195 200 205 Leu Phe Leu Asp Ser Val Leu Ile Leu Ile Ser Tyr Ile Ala Ile Leu 210 215 220 His Ser Val Leu Thr Ile Ala Ser Arg Asp Glu Arg Leu Lys Ser Leu 225 230 235 240 Lys Thr Cys Val Ser His Ile Cys Ala Val Leu Val Phe Tyr Ile Pro 245 250 255 Ile Ile Gly Leu Thr Met Val His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Val Val His Val Leu Met Gly Asn Ile Tyr Ile Leu Phe Pro Pro Leu 275 280 285 Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Gln Gln Ile Arg Ser Arg 290 295 300 Ile Gln Arg Trp Phe Ala Lys Gln Asn

305 310 <210> 3731 <211> 903 <212> DNA <213> Felis catus

Page 4180

069269_0225_SL.TXT <400> 3731 atggaaccaa gaaatcaaac gagtgtttca gaatttttac tcctgggatt ttcccaagac 60 tcagagcatc aacccattct atttgggcta ttcctgtcca tgtacctggt caccgtgctc 120 gggaatctgc tcatcatcct ggctgtcagc tctgactctc acctccacac ccccatgtac 180 ttcttcctct ccaacttgtc ctttgctgac atctgcttca cctccaccac cgtccctaag 240 atgctggtga acatccaaac acagagcaaa tccatcacct atgcaggctg catcacccag 300 atgtattttt tcatggtttt tggaggtatg gacacttttc tcctcactgt gatggcctat 360 gaccggtttg tagccatctg tcaccccttg cactacacag tcatcatgaa cccgtggctc 420 tgtggcctcc tggttcttgt gtcctggttc atcagcttgt catactccct gatccagagt 480 ctcttaatgt tgcggctgtc cttctgcacc aactgggtaa ttccacactt ttactgtgaa 540 cttgctcagg ccatcatgct tgcctgctca gacaccttgg ccaatcacat cctgctatat 600 attgtaacta gctttcttgg cattgttccc ttctcaggga tccttttctc ctatagccga 660 attgcctcct caatcctgag aatcccatca gctaatggga agtacaagac attttccacc 720 tgtgcatctc acttgtctgt ggtttctttg ttctatggga cagggcttgg tgtgtatctc 780 agttctgatg catcttcctg gaggggcatg attgcctcat tgatgtacac cgtggtcacc 840 ccaatgctga atcccttcat ctacagcctg cggaacaggg acatcaagag ggctttacaa 900 aaa 903 <210> 3732 <211> 301 <212> PRT <213> Felis catus <400> 3732

Met Glu Pro Arg Asn Gln Thr Ser Val Ser Glu Phe Leu Leu Leu Gly 1 5 10 15 Phe Ser Gln Asp Ser Glu His Gln Pro Ile Leu Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu Leu Ile Ile Leu Ala

35 40 45

Page 4181

069269_0225_SL.TXT

Val Ser 50 Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ser 55 60 Asn Leu Ser Phe Ala Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Val Asn Ile Gln Thr Gln Ser Lys Ser Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Met Val Phe Gly Gly Met Asp Thr 100 105 110 Phe Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Thr Val Ile Met Asn Pro Trp Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Phe Ile Ser Leu Ser Tyr Ser Leu Ile Gln Ser 145 150 155 160 Leu Leu Met Leu Arg Leu Ser Phe Cys Thr Asn Trp Val Ile Pro His 165 170 175 Phe Tyr Cys Glu Leu Ala Gln Ala Ile Met Leu Ala Cys Ser Asp Thr 180 185 190 Leu Ala Asn His Ile Leu Leu Tyr Ile Val Thr Ser Phe Leu Gly Ile 195 200 205 Val Pro Phe Ser Gly Ile Leu Phe Ser Tyr Ser Arg Ile Ala Ser Ser 210 215 220 Ile Leu Arg Ile Pro Ser Ala Asn Gly Lys Tyr Lys Thr Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Gly Thr Gly Leu 245 250 255

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Gly Val Tyr Leu Ser Ser Asp Ala Ser Ser Trp Arg Gly Met Ile Ala 260 265 270 Ser Leu Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile Tyr 275 280 285 Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Gln Lys 290 295 300

<210> 3733 <211> 996 <212> DNA <213> Felis catus <400> 3733

atgaattgct tgaatcaaaa tattcacact tagctggatg tctctacact tgttttgttt 60 attcaacact ctcttctttt tcaagaggtg tcccatcttc atggaaccac agaatctaac 120 tggtgtctca gaattcttcc tcatgggact ctcagatgac ctggaactac agccccttct 180 ctttgggctg ttcctgtcca tgtacctggt cactgtgctg gggaacctgc tcatcatcct 240 ggctgtcagc tctgaccccc acctctacac acccatgtac ttcttccttt ccaacctgtc 300 cttggctgac attggtttca gtaccactac gatccccaag atgctgttga acattcaaac 360 acacagtaga tctatcacct atgcagactg cctaactcag gtgtcctttt ttttcctatt 420 tggatgtttg gacaatctac tcctggctgt gatggcatat gaccggtttg tggccatttg 480 tcaccccctg cactacccag tcatcatgaa cccacgcctc tgtggctttt tggtcctcgt 540 gtcatttttc agcagccttt tggactctca gattcactgt ttgatggtgt cacaacttac 600 cttctgcaca agtgtggaaa tgcatcattt cttttgtgat gcacctcaac ttctccacct 660 tgcctgttct gatacctcca tcaatatcat actaatgtat ttcatggggg ccatttttgg 720 tggcattcca ctctcaggga tcctttgctc ttatactcga attgtttcct ccattctgag 780 agtcccatca acaggcggga agtacaaagc cttttctacc tgtggctctc acctatcagt 840 tgtttgcttg ttttatggaa caggtcttgg ggtatacctc agttcatctg tctcccccta 900 ccctaggaag ggtgcagtgg cctcggtcat gtacactgtg gtcaccccaa tgctgaaccc 960 cttcatctac agcctgagaa acaaggatat caagag 996

Page 4183

069269_0225_SL.TXT <210> 3734 <211> 320 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (320)..(320) <223> Any amino acid

<400> 3734 Leu Phe Asn Thr Leu Phe Phe Phe Lys Met Ser 1 Leu His Leu Phe 5 Cys 10 15 Arg Cys Pro Ile Phe Met Glu Pro Gln Asn Leu Thr Gly Val Ser Glu 20 25 30 Phe Phe Leu Met Gly Leu Ser Asp Asp Leu Glu Leu Gln Pro Leu Leu 35 40 45 Phe Gly Leu Phe Leu Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu 50 55 60 Leu Ile Ile Leu Ala Val Ser Ser Asp Pro His Leu Tyr Thr Pro Met 65 70 75 80 Tyr Phe Phe Leu Ser Asn Leu Ser Leu Ala Asp Ile Gly Phe Ser Thr 85 90 95 Thr Thr Ile Pro Lys Met Leu Leu Asn Ile Gln Thr His Ser Arg Ser 100 105 110 Ile Thr Tyr Ala Asp Cys Leu Thr Gln Val Ser Phe Phe Phe Leu Phe 115 120 125 Gly Cys Leu Asp Asn Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Phe 130 135 140 Val Ala Ile Cys His Pro Leu His Tyr Pro Val Ile Met Asn Pro Arg 145 150 155 160

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Leu Cys Gly Phe Leu Val Leu Val Ser Phe Phe Ser Ser Leu Leu Asp 165 170 175 Ser Gln Ile His Cys Leu Met Val Ser Gln Leu Thr Phe Cys Thr Ser 180 185 190 Val Glu Met His His Phe Phe Cys Asp Ala Pro Gln Leu Leu His Leu 195 200 205 Ala Cys Ser Asp Thr Ser Ile Asn Ile Ile Leu Met Tyr Phe Met Gly 210 215 220 Ala Ile Phe Gly Gly Ile Pro Leu Ser Gly Ile Leu Cys Ser Tyr Thr 225 230 235 240 Arg Ile Val Ser Ser Ile Leu Arg Val Pro Ser Thr Gly Gly Lys Tyr 245 250 255 Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ser Val Val Cys Leu Phe 260 265 270 Tyr Gly Thr Gly Leu Gly Val Tyr Leu Ser Ser Ser Val Ser Pro Tyr 275 280 285 Pro Arg Lys Gly Ala Val Ala Ser Val Met Tyr Thr Val Val Thr Pro 290 295 300 Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Xaa 305 310 315 320

<210> 3735 <211> 1037 <212> DNA <213> Felis catus <400> 3735 ttaagactag gctgttctgt taaggagcct ctgcaaggcc ctcttgatgt ccctgttcct caggctgtag atgaagggat tcagcatggg aacaaccaca gcatacatca tggaggccac

120

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tgcatccttc ctgggagaat gtgagacagt cgatcccagg aacaccccaa gacctgtccc 180 ataaaataag caaacaactg acaggtgaga gccacaggtg gagaaggctt tgtacttccc 240 acctgttgat gggactctca gaacggagga aagaattcgt gtataagaga aaaggatccc 300 tgagactgga ataccaccaa agatggcacc aataaaatac atgaatattt tattggtgga 360 agtgtcatta caggaaagct tgaggagttg aggagggtca cagaagaaat ggggaatttc 420 cacgtttgta cagaaggtaa gttgtgacac aatgaggcac tgcagctgag agtccagaag 480 gctgatcaaa aaagacacca gaatcagcag gcgacagagg cgggggttca tgatgactgg 540 gtagtacaga ggatagcaaa tagctacaaa tcgatcatag gccatcacgg ttaagagtac 600 actgtccaaa cagccaaaaa gattaaagag agacaactga atcaggcagc ccgcatggga 660 gatcactcgg ttatgagtct gaatgtccaa aatcaccttc gggacggtgg tagatgtgaa 720 accgatgtca gccacggaca gggtggaaag gaagacgtac atgggagtgt ggaggtggga 780 gtcagagctg acagccagga tgatgagcag attccctagc atggtgacca catacatgga 840 caggaacagg ctgaaggtta gaggctgccg gtctggatca tctgagaacc ccaggaggag 900 gaactccaac acatctgtta gattatctgg ttccacagag cagagacagc ttttggaaaa 960 taaatgagag tttacataac agaaacaagt atacaggaat ccaccagtgt ggctatactt 1020 tggatgcatg caattca 1037

<210> 3736 <211> 340 <212> PRT <213> Felis catus

<400> 3736 Met 1 His Pro Lys Tyr Ser His Thr Gly Gly Phe Leu Tyr Thr Cys Phe 5 10 15 Cys Tyr Val Asn Ser His Leu Phe Ser Lys Ser Cys Leu Cys Ser Val 20 25 30 Glu Pro Asp Asn Leu Thr Asp Val Leu Glu Phe Leu Leu Leu Gly Phe 35 40 45 Ser Asp Asp Pro Asp Arg Gln Pro Leu Thr Phe Ser Leu Phe Leu Ser Page 4186

069269_0225_SL.TXT

50 55 60

Met 65 Tyr Val Val Thr Met 70 Leu Gly Asn Leu Leu Ile Ile Leu Ala Val 75 80 Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Val Phe Leu Ser Thr 85 90 95 Leu Ser Val Ala Asp Ile Gly Phe Thr Ser Thr Thr Val Pro Lys Val 100 105 110 Ile Leu Asp Ile Gln Thr His Asn Arg Val Ile Ser His Ala Gly Cys 115 120 125 Leu Ile Gln Leu Ser Leu Phe Asn Leu Phe Gly Cys Leu Asp Ser Val 130 135 140 Leu Leu Thr Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Tyr Pro 145 150 155 160 Leu Tyr Tyr Pro Val Ile Met Asn Pro Arg Leu Cys Arg Leu Leu Ile 165 170 175 Leu Val Ser Phe Leu Ile Ser Leu Leu Asp Ser Gln Leu Gln Cys Leu 180 185 190 Ile Val Ser Gln Leu Thr Phe Cys Thr Asn Val Glu Ile Pro His Phe 195 200 205 Phe Cys Asp Pro Pro Gln Leu Leu Lys Leu Ser Cys Asn Asp Thr Ser 210 215 220 Thr Asn Lys Ile Phe Met Tyr Phe Ile Gly Ala Ile Phe Gly Gly Ile 225 230 235 240 Pro Val Ser Gly Ile Leu Phe Ser Tyr Thr Arg Ile Leu Ser Ser Val 245 250 255 Leu Arg Val Pro Ser Thr Gly Gly Lys Tyr Lys Ala Phe Ser Thr Cys

Page 4187

260

069269_0225_SL.TXT 265 270

Gly Ser His 275 Leu Ser Val Val Cys 280 Leu Phe Tyr Gly Thr Gly Leu Gly 285 Val Phe Leu Gly Ser Thr Val Ser His Ser Pro Arg Lys Asp Ala Val 290 295 300 Ala Ser Met Met Tyr Ala Val Val Val Pro Met Leu Asn Pro Phe Ile 305 310 315 320 Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Gln Arg Leu Leu 325 330 335

Asn Arg Thr Ala 340 <210> 3737 <211> 996 <212> DNA <213> Felis catus <400> 3737 ctcttgatat ccttgtttct caggctgtat atgaaggggt tcagcattgg ggtgaccaca 60 gtgtacatga ccgaggccac tgcacccttc ctagggtagg gggagacaga tgaactgagg 120 tataccccaa gacctgttcc ataaaacaag caaacaactg ataggtgaga gccacaggta 180 gaaaaagctt tgtacttccc gcctgttgat gggactctca gaatggagga aacaattcga 240 gtataagagc aaaggatccc tgagagtgga atgccaccaa aaatggcccc catgaaatat 300 attagtatgg tattgatgga ggtatcagaa caggcaaggt ggagaagttg aggtgcatca 360 caaaagaaat gatgcatttc cacacttgtg cagaaggtaa gttgtgacac catcaaacag 420 tgaatctgag agtccaaaag gctgctgaaa aatgacacga ggaccaaaaa gccacagagg 480 cgtgggttca tgatgactgg gtagtgcagg gggtgacaaa tggccacaaa ccggtcatat 540 gccatcacag ccaggagtag attgtccaaa catccaaata ggaaaaaaaa ggacacctga 600 gttaggcagt ctgcataggt gatagatcta ctgtgtgttt gaatgttcaa cagcatcttg 660 gggatcgtag tggtactgaa accaatgtca gccaaggaca ggttggaaag gaagaagtac 720

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069269_0225_SL.TXT atgggtgtgt agaggtgggg gtcagagctg acagccagga tgatgagcag gttccccagc acagtgacca ggtacatgga caggaacagc ccaaagagaa ggggctgtag ttccaggtca tctgagagtc ccatgaggaa gaattctgag acaccagtta gattctgtgg ttccatgaag atgggacacc tcttgaaaaa gaagagagtg ttgaataaac aaaacaagtg tagagacatc cagctaagtg tgaatatttt gattcaagca attcat

780

840

900

960

996 <210> 3738 <211> 320 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (320)..(320) <223> Any amino acid <400> 3738

Met 1 Ser Leu His Leu Phe 5 Cys Leu Phe Asn Thr Leu Phe Phe Phe Lys 10 15 Arg Cys Pro Ile Phe Met Glu Pro Gln Asn Leu Thr Gly Val Ser Glu 20 25 30 Phe Phe Leu Met Gly Leu Ser Asp Asp Leu Glu Leu Gln Pro Leu Leu 35 40 45 Phe Gly Leu Phe Leu Ser Met Tyr Leu Val Thr Val Leu Gly Asn Leu 50 55 60 Leu Ile Ile Leu Ala Val Ser Ser Asp Pro His Leu Tyr Thr Pro Met 65 70 75 80 Tyr Phe Phe Leu Ser Asn Leu Ser Leu Ala Asp Ile Gly Phe Ser Thr 85 90 95 Thr Thr Ile Pro Lys Met Leu Leu Asn Ile Gln Thr His Ser Arg Ser 100 105 110

Page 4189

Ile Thr Tyr 115 Ala Asp Cys Leu 069269_0225_SL.TXT Thr Gln Val Ser Phe Phe 120 125 Phe Leu Phe Gly Cys Leu Asp Asn Leu Leu Leu Ala Val Met Ala Tyr Asp Arg Phe 130 135 140 Val Ala Ile Cys His Pro Leu His Tyr Pro Val Ile Met Asn Pro Arg 145 150 155 160 Leu Cys Gly Phe Leu Val Leu Val Ser Phe Phe Ser Ser Leu Leu Asp 165 170 175 Ser Gln Ile His Cys Leu Met Val Ser Gln Leu Thr Phe Cys Thr Ser 180 185 190 Val Glu Met His His Phe Phe Cys Asp Ala Pro Gln Leu Leu His Leu 195 200 205 Ala Cys Ser Asp Thr Ser Ile Asn Thr Ile Leu Ile Tyr Phe Met Gly 210 215 220 Ala Ile Phe Gly Gly Ile Pro Leu Ser Gly Ile Leu Cys Ser Tyr Thr 225 230 235 240 Arg Ile Val Ser Ser Ile Leu Arg Val Pro Ser Thr Gly Gly Lys Tyr 245 250 255 Lys Ala Phe Ser Thr Cys Gly Ser His Leu Ser Val Val Cys Leu Phe 260 265 270 Tyr Gly Thr Gly Leu Gly Val Tyr Leu Ser Ser Ser Val Ser Pro Tyr 275 280 285 Pro Arg Lys Gly Ala Val Ala Ser Val Met Tyr Thr Val Val Thr Pro 290 295 300 Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Xaa 305 310 315 320

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069269_0225_SL.TXT <210> 3739 <211> 948 <212> DNA <213> Felis catus <400> 3739

tcagagggtc ttgcccccca gtcatctaga gtcattgccc ccacagaaca ccttcctcat 60 tgctcccgtc acatccctgt tccgcagagt atagatgaag gggttgacca tgggggtgac 120 gatggtgtag aagagagaaa tgaacttgcc ctgatcctgg gagtagttgt tgctgggctg 180 gaggtaagca tagatcgccg tgccgtagaa aagggaaacc accgtgaggt gggacccaca 240 tgtcccaaag gctttcctct gtcctgcggc tgactttatt cttaacactg ccctgacgat 300 tcgaccatag gagaacgtga ttaatgccac tggtatgagg agaatgatca caccgacaaa 360 gaagagcaca gactcattca cagtggtgtc aacacaggca agcttgagca gtggggggac 420 ctcacaaaag aagtggtcta ttttatttct cccacaaagt ggtacaagga aggtgagcac 480 cgtctgcaac gaggagttgg caaaaccaat gaaccacgat gcagaagcca tcagggcaca 540 gagacggggg tgcatgatca ctgtgtagta caggggtctg cagacggctg catagcggtc 600 aattgccatc acccccaaga gaatgcattc tgtggatccc aaccctagag aaacgaacag 660 ctgagctaca caggcagcaa aggagataga cttgtctgct cccctgagat gaaccagcag 720 ctgaggaaca gtgctggtcg tgtaacacag gtccagaaag cttagcttgg acaggaaaaa 780 gtacatggga gtctgcaggt gtgggtccag gagggacaac gcaatgatgg ttgtgtttcc 840 cagcagggtg agcagataga agatcagaag aaccacaaag aggactcgct ccagctgagg 900 ccggtcagag aaacccagca ggataaagcc agtgaaagaa cttccatt 948

<210> 3740 <211> 308 <212> PRT <213> Felis catus <400> 3740

Asn Gly Ser Ser Phe Thr Gly Phe Ile Leu Leu Gly Phe Ser Asp Arg 1 5 10 15 Pro Gln Leu Glu Arg Val Leu Phe Val Val Leu Leu Ile Phe Tyr Leu

20 25 30

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Leu Thr Leu 35 Leu Gly Asn Thr Thr Ile Ile Ala Leu Ser Leu Leu Asp 40 45 Pro His Leu Gln Thr Pro Met Tyr Phe Phe Leu Ser Lys Leu Ser Phe 50 55 60 Leu Asp Leu Cys Tyr Thr Thr Ser Thr Val Pro Gln Leu Leu Val His 65 70 75 80 Leu Arg Gly Ala Asp Lys Ser Ile Ser Phe Ala Ala Cys Val Ala Gln 85 90 95 Leu Phe Val Ser Leu Gly Leu Gly Ser Thr Glu Cys Ile Leu Leu Gly 100 105 110 Val Met Ala Ile Asp Arg Tyr Ala Ala Val Cys Arg Pro Leu Tyr Tyr 115 120 125 Thr Val Ile Met His Pro Arg Leu Cys Ala Leu Met Ala Ser Ala Ser 130 135 140 Trp Phe Ile Gly Phe Ala Asn Ser Ser Leu Gln Thr Val Leu Thr Phe 145 150 155 160 Leu Val Pro Leu Cys Gly Arg Asn Lys Ile Asp His Phe Phe Cys Glu 165 170 175 Val Pro Pro Leu Leu Lys Leu Ala Cys Val Asp Thr Thr Val Asn Glu 180 185 190 Ser Val Leu Phe Phe Val Gly Val Ile Ile Leu Leu Ile Pro Val Ala 195 200 205 Leu Ile Thr Phe Ser Tyr Gly Arg Ile Val Arg Ala Val Leu Arg Ile 210 215 220 Lys Ser Ala Ala Gly Gln Arg Lys Ala Phe Gly Thr Cys Gly Ser His 225 230 235 240

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Leu Thr Val Val Ser Leu Phe Tyr Gly Thr Ala Ile Tyr Ala Tyr Leu 245 250 255 Gln Pro Ser Asn Asn Tyr Ser Gln Asp Gln Gly Lys Phe Ile Ser Leu 260 265 270 Phe Tyr Thr Ile Val Thr Pro Met Val Asn Pro Phe Ile Tyr Thr Leu 275 280 285 Arg Asn Arg Asp Val Thr Gly Ala Met Arg Lys Val Phe Cys Gly Gly 290 295 300

Asn Asp Ser Arg 305 <210> 3741 <211> 970 <212> DNA <213> Felis catus <400> 3741

ttacatttta tgaataccat gcgcagtgcc aaagattttc ctcagagcag tcttcatttc 60 cttgttccta aggctataga ttagaggatt acagaggggt gttatcacag aataaagtaa 120 ggtcacaatt ttctgcattt tcactgggcg tcctgatcca ggactaacat acatcaccat 180 aacagagcca aaaaaacagg atcaccactg ccagatgaga agcacaagtg gagaaagcct 240 tgtgtttgcc tgctgctgag ggcatcctta gcacagacac aatcaccaga gcataggaac 300 aaagaacaaa gagaaagatt ccaatcataa aaatagcatt gaaagtagag taaatgaact 360 gtgttgtggt gtcttcagaa caggacagca tcatcaatgg gacaggatca cacatgaaat 420 ggttgatggt atttgggcca cagtagggta actgtgaaat gagaacaact ggggttagga 480 agaggacgaa cccgcacgac cagccaaaga tggcaaggcc agtgtacagc tgtttcgtca 540 taatgcgtgg gtaatgcaga ggacgacaga tggcaaggta cctgtcaaag gccatgatgc 600 agaggaagaa gccctcatca caccccagag agaagaagaa gtagaactgt gcaaaacagc 660 tcacaaagga aatggacttg cttgaggaca ggaaattggc caacatgtta gggacggtcg 720 tggtgacata acatatttcc aggagagaga aattccccaa gaggatgtac atgggcgtgt 780

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069269_0225_SL.TXT gaagacgccg ttcccaccgc actgcacaga caatggctgc gttccccatg agagtcagcg tgtagactac tgagaagagc ccgaagtaga ggagctgaat ttctgggctt gagggaaagc ccacgaggat aaagtggcta acggagttgg tggtttctgt gccggacaca ttcattggtc tggaagacat

840

900

960

970 <210> 3742 <211> 268 <212> PRT <213> Felis catus <400> 3742

Met Ser Ser 1 Arg Pro Met Asn Val 5 Ser Gly Thr Glu Thr Thr Asn Ser 10 15 Val Ser His Phe Ile Leu Val Gly Phe Pro Ser Ser Pro Glu Ile Gln 20 25 30 Leu Leu Tyr Phe Gly Leu Phe Ser Val Val Tyr Thr Leu Thr Leu Met 35 40 45 Gly Asn Ala Ala Ile Val Cys Ala Val Arg Trp Glu Arg Arg Leu His 50 55 60 Thr Pro Met Tyr Ile Leu Leu Gly Asn Phe Ser Leu Leu Glu Ile Cys 65 70 75 80 Tyr Val Thr Thr Thr Val Pro Asn Met Leu Ala Asn Phe Leu Ser Ser 85 90 95 Ser Lys Ser Ile Ser Phe Val Ser Cys Phe Ala Gln Phe Tyr Phe Phe 100 105 110 Phe Ser Leu Gly Cys Asp Glu Gly Phe Phe Leu Cys Ile Met Ala Phe 115 120 125 Asp Arg Tyr Leu Ala Ile Cys Arg Pro Leu His Tyr Pro Arg Ile Met 130 135 140

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Thr 145 Lys Gln Leu Tyr Thr 150 Gly Leu Ala Ile Phe Gly Trp Ser Cys Gly 155 160 Phe Val Leu Phe Leu Thr Pro Val Val Leu Ile Ser Gln Leu Pro Tyr 165 170 175 Cys Gly Pro Asn Thr Ile Asn His Phe Met Cys Asp Pro Val Pro Leu 180 185 190 Met Met Leu Ser Cys Ser Glu Asp Thr Thr Thr Gln Phe Ile Tyr Ser 195 200 205 Thr Phe Asn Ala Ile Phe Met Ile Gly Ile Phe Leu Phe Val Leu Cys 210 215 220 Ser Tyr Ala Leu Val Ile Val Ser Val Leu Arg Met Pro Ser Ala Ala 225 230 235 240 Gly Lys His Lys Ala Phe Ser Thr Cys Ala Ser His Leu Ala Val Val 245 250 255 Ile Leu Phe Phe Trp Leu Cys Tyr Gly Asp Val Cys

260 265 <210> 3743 <211> 950 <212> DNA <213> Felis catus <400> 3743

ttagctatct gtcttgagga aaaccctcag gactcgctcc ctaatctgtt tggtcctgac 60 cccatagatt ataggattga gagctggcgg aacaaccaca tataggttgg ccaagaaaat 120 gtggatatat tgagggatat tgtggccaaa tcggtgtgtc aagaaagaga aaaatgctgg 180 tgtgaaaaag gctaagataa ctccagtgtg ggagccacag gtgttgagag ctttgagtcg 240 ggcatccttg gagggtaagc agaagatagc atagaggatc ctgacatagg agagaattat 300 aaggagtaca tccaataata ggagagaaat gttgccaaga ccgaacataa tatttacttt 360 gatgctggca caggccaggc gagcaatgcc catgtgttca cagtaggtat gagggatgat 420

Page 4195

069269 0225 SL.TXT atagtgccca cagaagggca gcctcaagag gagaaatacc gctcctcaga atagccatgc ctgcaatgag gctgatgatt gtaccgaagg ggtttacaaa tggcaacata gcggtcaaag gctctccatg gcagtgaaga agtggatgaa gaacatctgg tatatccctg aggctgaacc agaagatgcc cagcattttg gcccaggtcg atggagtcca acatggctag gaagtagtac ctcagtctgg atcacaaaca ggacagcagc gttccccaag gaaaaaagga aatccaatcc agacgtgcac atcttctagc gaacgaagaa ggatggaact gggtgtcatt aagaatggac

agaggggcca ccatgcacag 480 ttgctggtga ggatcatggt 540 gccatggcca ccaacacaat 600 gaaaggcagc tttcaaaaga 660 gggatggtgg ctgtggacaa 720 acgggctcat ggagactatg 780 agtgcaacaa gatacgcaaa 840 cctgggatac ccaggaggag 900 attctctctg 950

<210> 3744 <211> 313 <212> PRT <213> Felis catus

<400> 3744 Met Ser Ile Leu Asn Asp Thr Gln Phe His Pro 1 5 10 Leu Gly Ile Pro Gly Leu Glu Asp Val His Val 20 25 Phe Phe Phe Ala Tyr Leu Val Ala Leu Leu Gly 35 40 Phe Val Ile Gln Thr Glu His Ser Leu His Glu 50 55 Leu Ala Met Leu Asp Ser Ile Asp Leu Gly Leu 65 70 75 Pro Lys Met Leu Gly Ile Phe Trp Phe Ser Leu 85 90 Glu Ser Cys Leu Ser Gln Met Phe Phe Ile His 100 105

Ser Ser Phe Leu 15 Leu Trp Ile Gly 30 Phe Pro Asn Ala 45 Ala Val Leu Pro 60 Val Tyr Tyr Phe Ser Thr Ala Thr Ile 80 Arg Asp Ile Ser 95 Phe Phe Phe Thr 110 Ala Met

Page 4196

069269_0225_SL.TXT

Glu Ser Ile 115 Val Leu Val Ala Met Ala Phe Asp Arg Tyr Val Ala Ile 120 125 Cys Lys Pro Leu Arg Tyr Thr Met Ile Leu Thr Ser Lys Ile Ile Ser 130 135 140 Leu Ile Ala Gly Met Ala Ile Leu Arg Ser Leu Cys Met Val Ala Pro 145 150 155 160 Leu Val Phe Leu Leu Leu Arg Leu Pro Phe Cys Gly His Tyr Ile Ile 165 170 175 Pro His Thr Tyr Cys Glu His Met Gly Ile Ala Arg Leu Ala Cys Ala 180 185 190 Ser Ile Lys Val Asn Ile Met Phe Gly Leu Gly Asn Ile Ser Leu Leu 195 200 205 Leu Leu Asp Val Leu Leu Ile Ile Leu Ser Tyr Val Arg Ile Leu Tyr 210 215 220 Ala Ile Phe Cys Leu Pro Ser Lys Asp Ala Arg Leu Lys Ala Leu Asn 225 230 235 240 Thr Cys Gly Ser His Thr Gly Val Ile Leu Ala Phe Phe Thr Pro Ala 245 250 255 Phe Phe Ser Phe Leu Thr His Arg Phe Gly His Asn Ile Pro Gln Tyr 260 265 270 Ile His Ile Phe Leu Ala Asn Leu Tyr Val Val Val Pro Pro Ala Leu 275 280 285 Asn Pro Ile Ile Tyr Gly Val Arg Thr Lys Gln Ile Arg Glu Arg Val 290 295 300 Leu Arg Val Phe Leu Lys Thr Asp Ser 305 310

Page 4197

069269_0225_SL.TXT <210> 3745 <211> 881 <212> DNA <213> Felis catus <400> 3745 caggcctaga gactgtgcag tgctggattg ggattccatt ctgtgtcatg tatctcattg 60 ctatgattgg aaactccttg attctgatca tcatcagggc agaacgcagc ctccatgagc 120 ccatgtacat ttttctaggc atgctgggag tcacagatat tgtacttggc acgagcattg 180 tgcccaagat gcttggaatc ttctggtttc atgtaccaga gatttattta gattcttgct 240 tgcttcaaat ggggctcatc cacacatttc agtgcataga gtcaggcatc ctgttggcca 300 tggctctgga ccgttatgtg gccatctgtt atccactaag acatgctgcc atcttcaccc 360 accgcctagt cacacaaata ggggctttgg taacactcag ggctgccctt ctcgtagccc 420 catctttagt actgataaaa tgccggtttc agttttacca tacaaccatc atctcccact 480 gctactgtga gcatatggcc attgtgaaac tggctgcaga aaatgtacga gtcaacaaaa 540 tctatggttt gtttgtggca ttcactgttg cagggtttga cctcatattc atcactttgt 600 cctacataca gatatttatc accgtttttc gtctgcccca gaaggaggct cggttgaaag 660 cattcaatac atgcatcgct cacatctgtg tcttcctcca gttctacctc cttgccttct 720 tctccttctt cacacatagg tttggtgctc atgttccccc ttatatccac atcctctttt 780 ctagcctcta cttgctggtc cccccatttc tcaatccact tgtctatggt gccaagacca 840 cgcagatccg cattcacctg gtaaagatgt tgtattcata a 881 <210> 3746 <211> 292 <212> PRT <213> Felis catus <400> 3746

Gly Leu Glu Thr Val Gln Cys Trp Ile Gly Ile Pro Phe Cys Val Met 1 5 10 15 Tyr Leu Ile Ala Met Ile Gly Asn Ser Leu Ile Leu Ile Ile Ile Arg

20 25 30

Page 4198

069269_0225_SL.TXT

Ala Glu Arg 35 Ser Leu His Glu Pro Met Tyr Ile Phe Leu Gly Met Leu 40 45 Gly Val Thr Asp Ile Val Leu Gly Thr Ser Ile Val Pro Lys Met Leu 50 55 60 Gly Ile Phe Trp Phe His Val Pro Glu Ile Tyr Leu Asp Ser Cys Leu 65 70 75 80 Leu Gln Met Gly Leu Ile His Thr Phe Gln Cys Ile Glu Ser Gly Ile 85 90 95 Leu Leu Ala Met Ala Leu Asp Arg Tyr Val Ala Ile Cys Tyr Pro Leu 100 105 110 Arg His Ala Ala Ile Phe Thr His Arg Leu Val Thr Gln Ile Gly Ala 115 120 125 Leu Val Thr Leu Arg Ala Ala Leu Leu Val Ala Pro Ser Leu Val Leu 130 135 140 Ile Lys Cys Arg Phe Gln Phe Tyr His Thr Thr Ile Ile Ser His Cys 145 150 155 160 Tyr Cys Glu His Met Ala Ile Val Lys Leu Ala Ala Glu Asn Val Arg 165 170 175 Val Asn Lys Ile Tyr Gly Leu Phe Val Ala Phe Thr Val Ala Gly Phe 180 185 190 Asp Leu Ile Phe Ile Thr Leu Ser Tyr Ile Gln Ile Phe Ile Thr Val 195 200 205 Phe Arg Leu Pro Gln Lys Glu Ala Arg Leu Lys Ala Phe Asn Thr Cys 210 215 220 Ile Ala His Ile Cys Val Phe Leu Gln Phe Tyr Leu Leu Ala Phe Phe 225 230 235 240

Page 4199

069269_0225_SL.TXT Ser Phe Phe Thr His Arg Phe Gly Ala His Val Pro Pro Tyr Ile His 245 250 255

Ile Leu Phe Ser Ser Leu Tyr Leu Leu Val Pro Pro Phe Leu Asn Pro 260 265 270

Leu Val Tyr Gly Ala Lys Thr Thr Gln Ile Arg Ile His Leu Val Lys 275 280 285

Met Leu Tyr Ser 290 <210> 3747 <211> 735 <212> DNA <213> Felis catus <400> 3747

gaagttttcc tttcaaactt catcccaaat gtgtatctta cctccttatt ccccaagcta 60 tagatgaggg ggttccacat gggcatcacc acagtgtaca acagagaaat cactttattg 120 agatccaggg agggacttga gccaggccga acagagataa gaaaagagtc ccatacagga 180 tggagacaac taccaggtga gaggagcagg tggacaaagg gttctgtctc ccatgagcaa 240 tctggatctt ccagatggcc accaggatgc aaacatggga gaccatcatg atcaggccac 300 tgaagattcc tgtagatcca gccaaaagaa aaatgtaagt tgagtcacag aagtgtctgc 360 acatgtaaga gagagcagaa gggaaatacc acagaagaaa tgattgatga tatttggacc 420 acacaagggt aagcaaaaag tcagtgtcat ataggtcatg ctgcttagaa gagccatgcc 480 ataaggccct acaaccagct gcacagagac cctctgggac gtaatgaggg catgcaacaa 540 gggcttaccg atggccaaat accagtcaca tgccatggac gtcaggaaga aacattcaga 600 taccccaaag aaagcagaga accacatctg agagagctga cttgtttctc tgcaaagata 660 tcacacagca tcttgggggc aatggaagaa gaggaacaat acctaaaagg acgaggggct 720 aagaaaaata catag 735

<210> 3748 <211> 50 <212> PRT

Page 4200

069269_0225_SL.TXT <213> Felis catus <400> 3748

Tyr 1 Val Phe Phe Leu Ala Pro Arg Pro Phe Arg Tyr Cys Ser Ser Ser 5 10 15 Ser Ile Ala Pro Lys Met Leu Cys Asp Ile Phe Ala Glu Lys Gln Val 20 25 30 Ser Ser Leu Arg Cys Gly Ser Leu Leu Ser Leu Gly Tyr Leu Asn Val 35 40 45

Ser Ser 50 <210> 3749 <211> 645 <212> DNA <213> Felis catus <400> 3749 tcattgggag actgtcaaaa tacacctttt ctccattgtg ccaaagttcc tccgaaaccc 60 tgttctcaaa gcctgcttca catctttgtt cctcaggctg tagatagatt cagcatgaga 120 ctcacaaaga tacaaaccac tgccacaatt ttccctgttc aacagactgc tcaggggctg 180 ttctcataca tacagaatag ggacccccaa aacatggcaa cagcgatcag gtgggagcca 240 cgggtggaga aggctttgca ctggcctttg ctggaaggga tcctcatgat ggtggtgaaa 300 atgaaaatgt aggagataag gatgatgagt aggatataag gatggaacag tgaggttaat 360 ccccacacac aaacagagca gtctgctttc tgtaagtatc tgatcctgtc agcatcagga 420 ggggtggggc agcacataga aagggttgat gaagttgtgt ccataaaagt ataagcagga 480 ggtcaatagt atctgcattg tgcccaccat agtacccaga ggtagggggc agtgacaagg 540 cagatgcaaa gggacctgga cattctgctg ctgtagtgta ggggatggca gatggccatg 600 tacctgtcag aggccatggt gcccagcgca taatactgca taagg 645 <210> 3750 <211> 103 <212> PRT <213> Felis catus

Page 4201

069269_0225_SL.TXT

<400> 3750 Cys Gln 5 Asn Thr Pro Phe Leu His Cys Ala Lys Val Ser Leu 1 Gly Asp 10 15 Pro Pro Lys Pro Cys Ser Gln Ser Leu Leu His Ile Phe Val Pro Gln 20 25 30 Ala Val Asp Arg Phe Ser Met Arg Leu Thr Lys Ile Gln Thr Thr Ala 35 40 45 Thr Ile Phe Pro Val Gln Gln Thr Ala Gln Gly Leu Phe Ser Tyr Ile 50 55 60 Gln Asn Arg Asp Pro Gln Asn Met Ala Thr Ala Ile Arg Trp Glu Pro 65 70 75 80 Arg Val Glu Lys Ala Leu His Trp Pro Leu Leu Glu Gly Ile Leu Met 85 90 95

Met Val Val Lys Met Lys Met 100

<210> 3751 <211> 651 <212> DNA <213> Felis catus <400> 3751 ccttatgcag tattatgtgc tgggcaccat ggcctctgac aggtacatgg ccatctgcca 60 tcccctacac tacaacagca gaatgtccag gcccctttgc atctgccttg tcactgcccc 120 ctacctctgg gtactatggt gggcacaatg cagatactat tgacctcctg cttatacttt 180 tatggacaca acttcatcaa ccctttctat gtgctgaccc acccctcctg atgctgacag 240 gatcagacac ttacagaaag cagactgctc tgtttgagtg tggggattaa cctcaccttt 300 ccatccttat atcctactta tcatccttat ctcctaaatt ttcgttttca ccaccatcat 360 gaggatacct tccagcaaag gccagtgcaa agccttctcc acccgtggct cccacctgat 420 cgctgtcgcc atgtttttgg ggtccctatt ctgtatgtat ctgagaacag cccctgagca 480

Page 4202

069269_0225_SL.TXT gtctgttgaa cagggaaaat tgtggcagtg gtttgtatct ttgtgagtct catgctgaat 540 ctatttatct acagcctgag gaacaaagat gtgaagcagg ctttgagaac agggttttgg 600 aggagctttg gcccaatgga gaaaaggtgt attttgacag tctcccaatg a 651 <210> 3752 <211> 95 <212> PRT <213> Felis catus

<400> 3752 Met Cys 5 Trp Ala Pro Trp Pro Leu Thr Gly Thr Trp Leu Cys 1 Ser Ile 10 15 Pro Ser Ala Ile Pro Tyr Thr Thr Thr Ala Glu Cys Pro Gly Pro Phe 20 25 30 Ala Ser Ala Leu Ser Leu Pro Pro Thr Ser Gly Tyr Tyr Gly Gly His 35 40 45 Asn Ala Asp Thr Ile Asp Leu Leu Leu Ile Leu Leu Trp Thr Gln Leu 50 55 60 His Gln Pro Phe Leu Cys Ala Asp Pro Pro Leu Leu Met Leu Thr Gly 65 70 75 80 Ser Asp Thr Tyr Arg Lys Gln Thr Ala Leu Phe Glu Cys Gly Asp 85 90 95

<210> 3753 <211> 964 <212> DNA <213> Felis catus <400> 3753 atgtccatct caaatgccag tgcaataaca gaattcattc tcctggggct cacagaccgg 60 cctgaactcc aacttctctt ctttgtgctg tttctggttt tgtatcttgt caccctctca 120 ggcaacctgg gcatgatgct gttgatcaga ctggactctc ggctccacac acccatgtac 180 ttcttcctca ctaatttggc ctttgtggac ttgtgttaca cctcaaatgc aaccccacag 240 atgttgacta atttcttatc ggagaagaag accatcacct ttgttggctg ctttacacaa 300

Page 4203

069269_0225_SL.TXT tgttacattt tcattgcgct tctcctcact gaccgctacg tggccatatg taaccctctg tgcctctgtt tggccacatt gccttatgtc ctcctgacct tccgcttgaa cttctgtaga gacccaccac tgattaagct ttcttgctct atatcagctg gcttcaatct ctccaactcc attattggtg ccatcctccg gatcaaatcg tgtggctccc acatgatggc tgtgaccctc agaccaccaa cagataagac tgtagaggaa gtaagtccgg tgcttaatcc attgatatac ttgaaaaatg tcctcagagg aaataggtca aatc <210> 3754 <211> 314 <212> PRT <213> Felis catus gagatttaca tattggcggc aatggcctat cgctatagta tgaaaatgtc caggcgcatc tatggcttct cagatgggct gttccaggcc tccaatgtca tcaaccactt ctactgtgct gatacgtatg tcaaagagca tgccatgctc ctctgcatca tcctggtgtc ctatgccttc gcagagggca ggcgcaaggc attctccacc ttttatggga cactcttctg catgtatgta tccaaaataa tagctgtctt gtacactttt agtctgcgga acaaggatgt aaagcaagcc ctaacatggg actgaccctg atttccaatg

360

420

480

540

600

660

720

780

840

900

960

964

<400> 3754 Met Ser Ile Ser Asn Ala Ser Ala 1 5 Leu Thr Asp Arg Pro Glu Leu Gln 20 Val Leu Tyr Leu Val Thr Leu Ser 35 40 Ile Arg Leu Asp Ser Arg Leu His 50 55 Asn Leu Ala Phe Val Asp Leu Cys 65 70

Ile Thr 10 Glu Phe Ile Leu Leu 15 Gly Leu 25 Leu Phe Phe Val Leu 30 Phe Leu Gly Asn Leu Gly Met 45 Met Leu Leu Thr Pro Met Tyr 60 Phe Phe Leu Thr Tyr Thr Ser 75 Asn Ala Thr Pro Gln 80

Page 4204

Met Leu Thr Asn Phe 85 Leu Ser 069269_0225_SL.TXT Phe Val 95 Gly Glu Lys Lys Thr Ile Thr 90 Cys Phe Thr Gln Cys Tyr Ile Phe Ile Ala Leu Leu Leu Thr Glu Ile 100 105 110 Tyr Ile Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn 115 120 125 Pro Leu Arg Tyr Ser Met Lys Met Ser Arg Arg Ile Cys Leu Cys Leu 130 135 140 Ala Thr Leu Pro Tyr Val Tyr Gly Phe Ser Asp Gly Leu Phe Gln Ala 145 150 155 160 Leu Leu Thr Phe Arg Leu Asn Phe Cys Arg Ser Asn Val Ile Asn His 165 170 175 Phe Tyr Cys Ala Asp Pro Pro Leu Ile Lys Leu Ser Cys Ser Asp Thr 180 185 190 Tyr Val Lys Glu His Ala Met Leu Ile Ser Ala Gly Phe Asn Leu Ser 195 200 205 Asn Ser Leu Cys Ile Ile Leu Val Ser Tyr Ala Phe Ile Ile Gly Ala 210 215 220 Ile Leu Arg Ile Lys Ser Ala Glu Gly Arg Arg Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Met Met Ala Val Thr Leu Phe Tyr Gly Thr Leu Phe 245 250 255 Cys Met Tyr Val Arg Pro Pro Thr Asp Lys Thr Val Glu Glu Ser Lys 260 265 270 Ile Ile Ala Val Leu Tyr Thr Phe Val Ser Pro Val Leu Asn Pro Leu 275 280 285

Page 4205

069269_0225_SL.TXT Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys Gln Ala Leu Lys Asn Val 290 295 300 Leu Arg Gly Asn Arg Ser Leu Thr Trp Asp 305 310

<210> 3755 <211> 940 <212> DNA <213> Felis catus <400> 3755

atggagtact ggaactccac cctgggcagt ggctttatat tgatggggat tctgaaagac 60 agtgggtctc ctgaactgct ctgtgtcata atcacagtcc tgtacatgtt ggccctgacc 120 agcaatggcc tgctgctctt ggtcatcaca gtggattccc ggctccacgt gcccatgtac 180 ttcctcctcg ggcagctctc actcatggac ctcctcttca catctgttgt cactcccaag 240 gcgctcatgg attttctgcg cagtgaaaac accatctcct ttgcgggctg tgcccttcag 300 atgttcctgg cattgatgct gggtggtgca gaggacctgc tactggcctt catggcctat 360 gatagatatg tggccatttg tcatcctctg aactacatgg tcttcatgag gccaagggtc 420 tgctggctca tggtggccac agcatggata ctggcatacc tgaatgctct aggacatacc 480 ttctatacca tgcagtatcc cttctgcaaa gcccggaaca tcaggcacct gctctgtgag 540 attccacctt tgctgaagtt ggcctgtgca gaaacctcca gatatgaact cttggtgtat 600 gtgacagggg tgattttcct tttgctccct ctttctgcca ttattgcctc ctatgcacta 660 atcctgttta ctgtgcttca catgccctca aatgagggga ggcacaaagc cctagtcacc 720 tgttcttccc atctgactgt ggttgggatg ttctatggag ctgccacatt catgtatgtc 780 ctgcccagct cccttcacag ccccaagcaa gacaacatca tctctgtttt ctacacggtt 840 gtcactccag ccctgaaccc ccttatctac accttgagga ataagaaagt gatgggggcc 900 ttgaggaggg tcctaggaaa atatatattg ccaacccact 940

<210> 3756 <211> 314 <212> PRT <213> Felis catus

Page 4206

069269_0225_SL.TXT <220>

<221> MOD_RES <222> (314)..(314) <223> Any amino acid

<400> 3756 Met 1 Glu Tyr Trp Asn Ser 5 Thr Leu Gly Ser 10 Gly Phe Ile Leu Met 15 Gly Ile Leu Lys Asp Ser Gly Ser Pro Glu Leu Leu Cys Val Ile Ile Thr 20 25 30 Val Leu Tyr Met Leu Ala Leu Thr Ser Asn Gly Leu Leu Leu Leu Val 35 40 45 Ile Thr Val Asp Ser Arg Leu His Val Pro Met Tyr Phe Leu Leu Gly 50 55 60 Gln Leu Ser Leu Met Asp Leu Leu Phe Thr Ser Val Val Thr Pro Lys 65 70 75 80 Ala Leu Met Asp Phe Leu Arg Ser Glu Asn Thr Ile Ser Phe Ala Gly 85 90 95 Cys Ala Leu Gln Met Phe Leu Ala Leu Met Leu Gly Gly Ala Glu Asp 100 105 110 Leu Leu Leu Ala Phe Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His 115 120 125 Pro Leu Asn Tyr Met Val Phe Met Arg Pro Arg Val Cys Trp Leu Met 130 135 140 Val Ala Thr Ala Trp Ile Leu Ala Tyr Leu Asn Ala Leu Gly His Thr 145 150 155 160 Phe Tyr Thr Met Gln Tyr Pro Phe Cys Lys Ala Arg Asn Ile Arg His 165 170 175 Leu Leu Cys Glu Ile Pro Pro Leu Leu Lys Leu Ala Cys Ala Glu Thr

Page 4207

180

069269_0225_SL.TXT 185 190

Ser Arg Tyr Glu Leu Leu Val Tyr Val Thr Gly Val Ile Phe Leu Leu 195 200 205 Leu Pro Leu Ser Ala Ile Ile Ala Ser Tyr Ala Leu Ile Leu Phe Thr 210 215 220 Val Leu His Met Pro Ser Asn Glu Gly Arg His Lys Ala Leu Val Thr 225 230 235 240 Cys Ser Ser His Leu Thr Val Val Gly Met Phe Tyr Gly Ala Ala Thr 245 250 255 Phe Met Tyr Val Leu Pro Ser Ser Leu His Ser Pro Lys Gln Asp Asn 260 265 270 Ile Ile Ser Val Phe Tyr Thr Val Val Thr Pro Ala Leu Asn Pro Leu 275 280 285 Ile Tyr Thr Leu Arg Asn Lys Lys Val Met Gly Ala Leu Arg Arg Val 290 295 300 Leu Gly Lys Tyr Ile Leu Pro Thr His Xaa

305 310 <210> 3757 <211> 942 <212> DNA <213> Felis catus <400> 3757 aaaaagcaca cagagggttc ctattcagca attttttcac agctactttt acctctttgt tccgtaaact ataaatgata ggattcaaca tgggggttaa tccagcatat accaaagcca taaatttgtc tatttcctgt gaatctacag cggagggctt caggtacatg gagagagctg tcccatagaa caaaaccacc acagtcaggt gggctgcgca tgttgaaaag gctttgcttc caccatccac tgagctgatt ctcaggatgc ttggagagaa tgaatgcgta agagacacaa atgaggagca tcggcatagg aagaagaagt acgctgatca ccagcatgat caactgcacc Page 4208

120

180

240

300

360

069269_0225_SL.TXT

ctggaagtat ccacacaaac tagtttcaac acagccagaa tttcacaagt gaagtgattg 420 atgatgccac ttccacagac agacagctgc agcacagata ctgtttccac cagggcggtg 480 aggcagcctg tcatccagga gccagcggca atctgcacac aagccctctt gttcatgatg 540 atggggtatc tcagaggatt gcagatggcc acataccggc catacgccat cgtggacagg 600 agcacacact cagtggagcc catggcaaga gaaaagtaca tctgagtggc acatcctgag 660 aatgagatgg tgtttttccc tgaaacaaag tttgtcagca ttggagtgag agcagaagag 720 gtgtaccaga tgtctaaaaa ggagaggttg ctgaggaaga agtacatggg tttgtgtagg 780 tgggaatcca ggatggtgat ggacatcaga atgatattac ccagcagggt gatcaggtac 840 atcagcaagc acagcacaaa tatgatgacc tcaactttgg ggtaacgagt aaaccccagg 900 aaaataaaat taggaaatga ctgtcaagtt tgccttgacc at 942

<210> 3758 <211> 57 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (57)..(57) <223> Any amino acid <400> 3758

Met Tyr Leu Lys Pro Ser Ala Val Asp Ser Gln Glu Ile Asp Lys Phe 1 5 10 15 Met Ala Leu Val Tyr Ala Gly Leu Thr Pro Met Leu Asn Pro Ile Ile 20 25 30 Tyr Ser Leu Arg Asn Lys Glu Val Lys Val Ala Val Lys Lys Leu Leu 35 40 45 Asn Arg Asn Pro Leu Cys Ala Phe Xaa 50 55

<210> 3759 <211> 922

Page 4209

069269_0225_SL.TXT <212> DNA <213> Felis catus <400> 3759

agaaccagag cagcatgtcc gagttcctac tcctggggct ccccatacgg ccagagcagc 60 agggcatgtt cttcaccctg ttcctgggca tgtacctgac cacggtgctg gggaacctgc 120 tcatcatcct gctcatcagg ctggactctc gcctccacac gcccatgtac ttcttcctca 180 gccacttggc cttctctgat atctctttct catctgtcac cgtcccaaag atgctgatga 240 acatgcagac tcagcactta tccatcccct atgtggcatg catttcccag atgtattttt 300 tcatattttt tgtctgtctt gacaatttcc ttcttgcagt gatggcatat gacaggtatg 360 tggccatctg tcaaccactc cactacacca ctgtcatgag ggaggagctg tgtatcttac 420 tggtggctgg atcctggttc ttctcttgtg cccatgccct attgcatgct ctccttctgt 480 cccgcctgtc cttctgtgct gacaatacca tccctcattt cttttgtgat ctcactgccc 540 ttttgaagtt gatctgctca gacacctccc tcaatgagct agttatcttc accgaggggg 600 gagtctttgc cttcctgcca ttgtgtgcta ttttgggctc ttatattcgc attggggcca 660 ccatcctagg ggttccctcc atcaagagga tctgcaaagc cttgtctacc tgtggctccc 720 accttcttgt ggtgtttttg tactatggga ctcttgcaat gatttacttc attccttcat 780 caaacaattc caaagtcaaa gatatagttg tttcagttat atatacagtg gtgacaccca 840 tgttaaaccc ctttatctat agcctgagga acggggacat gaaattggct ctggggatac 900 tttataggag gaaaattatt tt 922

<210> 3760 <211> 303 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (303)..(303) <223> Any amino acid <400> 3760

Met Ser Glu Phe Leu Leu Leu Gly Leu Pro Ile Arg Pro Glu Gln Gln 1 5 10 15

Page 4210

069269_0225_SL.TXT

Gly Met Phe Phe 20 Thr Leu Phe Leu Gly Met Tyr Leu Thr Thr Val Leu 25 30 Gly Asn Leu Leu Ile Ile Leu Leu Ile Arg Leu Asp Ser Arg Leu His 35 40 45 Thr Pro Met Tyr Phe Phe Leu Ser His Leu Ala Phe Ser Asp Ile Ser 50 55 60 Phe Ser Ser Val Thr Val Pro Lys Met Leu Met Asn Met Gln Thr Gln 65 70 75 80 His Leu Ser Ile Pro Tyr Val Ala Cys Ile Ser Gln Met Tyr Phe Phe 85 90 95 Ile Phe Phe Val Cys Leu Asp Asn Phe Leu Leu Ala Val Met Ala Tyr 100 105 110 Asp Arg Tyr Val Ala Ile Cys Gln Pro Leu His Tyr Thr Thr Val Met 115 120 125 Arg Glu Glu Leu Cys Ile Leu Leu Val Ala Gly Ser Trp Phe Phe Ser 130 135 140 Cys Ala His Ala Leu Leu His Ala Leu Leu Leu Ser Arg Leu Ser Phe 145 150 155 160 Cys Ala Asp Asn Thr Ile Pro His Phe Phe Cys Asp Leu Thr Ala Leu 165 170 175 Leu Lys Leu Ile Cys Ser Asp Thr Ser Leu Asn Glu Leu Val Ile Phe 180 185 190 Thr Glu Gly Gly Val Phe Ala Phe Leu Pro Leu Cys Ala Ile Leu Gly 195 200 205 Ser Tyr Ile Arg Ile Gly Ala Thr Ile Leu Gly Val Pro Ser Ile Lys 210 215 220

Page 4211

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Arg Ile Cys 225 Lys Ala Leu Ser Thr Cys Gly Ser His Leu Leu Val Val 240 230 235 Phe Leu Tyr Tyr Gly Thr Leu Ala Met Ile Tyr Phe Ile Pro Ser Ser 245 250 255 Asn Asn Ser Lys Val Lys Asp Ile Val Val Ser Val Ile Tyr Thr Val 260 265 270 Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn Gly Asp 275 280 285 Met Lys Leu Ala Leu Gly Ile Leu Tyr Arg Arg Lys Ile Ile Xaa 290 295 300

<210> 3761 <211> 909 <212> DNA <213> Felis catus <400> 3761

ttttcgtagg gcccccttca agtccctgtt cctcaggctg tagatgaagg ggttcagcat 60 gggggtcacc acggtataca tcacagtagc tgctgtatcc ttctcagaag agtgtgagga 120 caaagggttg aaatacacag caatgatggt gccatagaag agggaaacca cggccaggtg 180 cgagccacag gtggagaagg ctttccatct tcccttcgtg gacgggactc tcaggacagc 240 gcaggtaata tggacatacg aagccaggat gcaaataaat ggagagatca tgatcagaga 300 accctcagtc agaatcatca cctcattgag gtgggtgtca gagcaggaca gtttcaggag 360 gggagtcaca tcacagaaga agtgggggat ggcattgtct gcacagaacg agagtcgagc 420 cattaacagg gtatgcagta gagcattcag gctggcaatg acccatgacc cagcaaccag 480 cagggcacag agccggtggg tcatctttgt cgagtagtgt aaggggtggc atatggcaac 540 aaagcggtca taggccatca cagccaggag gaaattgtcc atgtcggcaa gctcaaagag 600 aaaatacatc tgtgtgagac acccagagaa ggagatggcc tgagtcccaa ggatgtggtt 660 ggccagcatc ttggggacgg tggtggtgga gaagcagatg tccacaaagg acaggtggct 720 gaggaggaag tacatgggga tgtgcaggcg ggggtccacg cagatggcca ggaggatgag 780

Page 4212

069269_0225_SL.TXT caggtttccc gggaccgtgg ccaggtacat gctcaggaag agcgcaaaga gggcctgctg ctgctggggc tgcctggaga gcccgaggag gaggaactcg gagacactcg actggtttgc tcctctcat

840

900

909 <210> 3762 <211> 303 <212> PRT <213> Felis catus

<400> 3762 Gln Ser Ser Val Ser Glu Phe Leu Leu Leu Gly Met Arg 1 Gly Ala Asn 5 10 15 Leu Ser Arg Gln Pro Gln Gln Gln Gln Ala Leu Phe Ala Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ala Thr Val Pro Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 Ile Cys Val Asp Pro Arg Leu His Ile Pro Met Tyr Phe Leu Leu Ser 50 55 60 His Leu Ser Phe Val Asp Ile Cys Phe Ser Thr Thr Thr Val Pro Lys 65 70 75 80 Met Leu Ala Asn His Ile Leu Gly Thr Gln Ala Ile Ser Phe Ser Gly 85 90 95 Cys Leu Thr Gln Met Tyr Phe Leu Phe Glu Leu Ala Asp Met Asp Asn 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Pro Leu His Tyr Ser Thr Lys Met Thr His Arg Leu Cys Ala Leu Leu 130 135 140 Val Ala Gly Ser Trp Val Ile Ala Ser Leu Asn Ala Leu Leu His Thr 145 150 155 160

Page 4213

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Leu Leu Met Ala Arg Leu Ser Phe Cys Ala Asp Asn Ala Ile Pro His 165 170 175 Phe Phe Cys Asp Val Thr Pro Leu Leu Lys Leu Ser Cys Ser Asp Thr 180 185 190 His Leu Asn Glu Val Met Ile Leu Thr Glu Gly Ser Leu Ile Met Ile 195 200 205 Ser Pro Phe Ile Cys Ile Leu Ala Ser Tyr Val His Ile Thr Cys Ala 210 215 220 Val Leu Arg Val Pro Ser Thr Lys Gly Arg Trp Lys Ala Phe Ser Thr 225 230 235 240 Cys Gly Ser His Leu Ala Val Val Ser Leu Phe Tyr Gly Thr Ile Ile 245 250 255 Ala Val Tyr Phe Asn Pro Leu Ser Ser His Ser Ser Glu Lys Asp Thr 260 265 270 Ala Ala Thr Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Leu Lys Gly Ala Leu Arg Lys 290 295 300

<210> 3763 <211> 959 <212> DNA <213> Felis catus <400> 3763 ttcttcaacc acaggacaat tggacctttt ctaactgcca tcgcagagaa tctcctcaga gccttcttta tgtctttgtt cctcaggctg tagatgaagg ggttcagcat gggcgtgacc accgtgtaca tcactgaggc tgtggcactt gagtgggagc tctgggtagc agcagagctc aggtacactc cgaggcccgt acaataaaat aaggagacaa ccgagaggtg agatgcacag

120

180

240

Page 4214

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gtggaaaatg ccttatactt gccctgagct gatgagatcc cacgtatgga ggaaactatc 300 ttagagtaag agtaaaggat cccaacgaaa ggaccaccac ccactaggat agctgcaaaa 360 tacatcacca agttactaat aaaggtgtca gaacaggcaa gttggatcac ctgattgagt 420 tcacaggaaa aatgggggat ttccaagact gtacagaagg acagccgcaa caccattgaa 480 gtttgcaaca aggaatgcaa gacactcgtg atccaggaca ccaggaccag cggtgcacag 540 agccgggggc tcatgatgac cgtgtattgc agggagtgac agatggccac aaacctgtca 600 tagaccataa tgtccaggag gcagatgtcc aatcctgaaa agattatgaa aaagttcacc 660 tgtgtgatgc agtcctcata ggttatgact ttgctctggg tctggatgtt ccagagcatc 720 ttcgggacgg tggtggaagt gatgcagatg tctacagagg acaggttggc caggaagaag 780 tacatggggg tgtggaggcg ggagtcagag ctgacggcca ggaggatgag caggttccca 840 aacacagtga tcaggtacat ggagaggaaa agcccaaata cgaggggttg ctgttctgga 900 ccctctgaaa atcccagaag cagaaattct gatgtccgtg tatcatttcc tggttccat 959

<210> 3764 <211> 320 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (320)..(320) <223> Any amino acid <400> 3764

Met 1 Glu Pro Gly Asn Asp Thr Arg Thr Ser Glu Phe Leu Leu Leu Gly 5 10 15 Phe Ser Glu Gly Pro Glu Gln Gln Pro Leu Val Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 Val Ser Ser Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala

50 55 60

Page 4215

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Asn 65 Leu Ser Ser Val Asp Ile Cys Ile Thr Ser Thr Thr Val Pro Lys 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Glu Asp 85 90 95 Cys Ile Thr Gln Val Asn Phe Phe Ile Ile Phe Ser Gly Leu Asp Ile 100 105 110 Cys Leu Leu Asp Ile Met Val Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125 Ser Leu Gln Tyr Thr Val Ile Met Ser Pro Arg Leu Cys Ala Pro Leu 130 135 140 Val Leu Val Ser Trp Ile Thr Ser Val Leu His Ser Leu Leu Gln Thr 145 150 155 160 Ser Met Val Leu Arg Leu Ser Phe Cys Thr Val Leu Glu Ile Pro His 165 170 175 Phe Ser Cys Glu Leu Asn Gln Val Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Ile Ser Asn Leu Val Met Tyr Phe Ala Ala Ile Leu Val Gly Gly 195 200 205 Gly Pro Phe Val Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270

Page 4216

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Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met 280 Leu 285 Asn Pro Phe 275 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Lys Ala Leu Arg Arg Phe 290 295 300 Ser Ala Met Ala Val Arg Lys Gly Pro Ile Val Leu Trp Leu Lys Xaa 305 310 315 320

<210> 3765 <211> 925 <212> DNA <213> Felis catus <400> 3765

aatttctttt ggacaacttt cctgattgct tgtttaacat ctttgttccg caggctatag 60 atcaaagggt ttagcatagg gctcgcaaag atataaaaaa ctgcgacaat tttcccctgt 120 tctacagatg cctcggaagg gggtctcaga tacatgcaga atagcgtccc ataaaaggtg 180 gtgacggccg tcaagtggga cccacaggtg gagaaggcct tgcgcctccc ctctgcagaa 240 cggatgcgca gaatcgtcgt gaaaatgaaa atgtaggaga tgagaatgat ggcaagagag 300 catgtgagat tgaaaccagc caccacaaac atggcagttt cttgacatac gtatccgagc 360 aggcaaggac tatgagaggt gggtccgcac agtagaagtg gttgatttca ttgggtccac 420 agaaggagag gcgaagcatc aggatggtct gtgccaggcc atttgcaaaa ccgtaaatat 480 agggcgtagc aacaagagag aggcagacac atctggacat cttgctaccg tacagcaagg 540 ggttgcagat cgccatgtag cggtcgtaag ccatcaccgt cagcatataa taatccgtga 600 tcaccagggc aatgaaaaag tggaactgta gaaggcaacc aaggaaggaa atggcttttc 660 tcttggataa gaaatgaacc agcatctgcg gagcgacact ggtagcgtaa cagagatcca 720 caaaggagag atggctgagg aagaagtaca tgggcgtgtg aagttttgag tcacttcgga 780 ttaacaaaat catgctcacg ttgccaacta ctgtgataag gtagatgacc aggaagacca 840 caaaaaggac aggctgcaac tcggctcgat ctgtcagtcc caggaggata aactcagtca 900 ctgctgtgta gtttgtctgt aacat 925

Page 4217

069269_0225_SL.TXT <210> 3766 <211> 244 <212> PRT <213> Felis catus

<400> 3766 Asn Tyr Thr Ala Val Thr Glu Phe Ile Leu Leu Gly Met 1 Leu Gln Thr 5 10 15 Leu Thr Asp Arg Ala Glu Leu Gln Pro Val Leu Phe Val Val Phe Leu 20 25 30 Val Ile Tyr Leu Ile Thr Val Val Gly Asn Val Ser Met Ile Leu Leu 35 40 45 Ile Arg Ser Asp Ser Lys Leu His Thr Pro Met Tyr Phe Phe Leu Ser 50 55 60 His Leu Ser Phe Val Asp Leu Cys Tyr Ala Thr Ser Val Ala Pro Gln 65 70 75 80 Met Leu Val His Phe Leu Ser Lys Arg Lys Ala Ile Ser Phe Leu Gly 85 90 95 Cys Leu Leu Gln Phe His Phe Phe Ile Ala Leu Val Ile Thr Asp Tyr 100 105 110 Tyr Met Leu Thr Val Met Ala Tyr Asp Arg Tyr Met Ala Ile Cys Asn 115 120 125 Pro Leu Leu Tyr Gly Ser Lys Met Ser Arg Cys Val Cys Leu Ser Leu 130 135 140 Val Ala Thr Pro Tyr Ile Tyr Gly Phe Ala Asn Gly Leu Ala Gln Thr 145 150 155 160 Ile Leu Met Leu Arg Leu Ser Phe Cys Gly Pro Asn Glu Ile Asn His 165 170 175 Phe Tyr Cys Ala Asp Pro Pro Leu Ile Val Leu Ala Cys Ser Asp Thr 180 185 190

Page 4218

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Tyr Val Lys Lys Leu Pro Cys Leu Trp Trp Leu Val Ser Ile Ser His 195 200 205 Ala Leu Leu Pro Ser Phe Ser Ser Pro Thr Phe Ser Phe Ser Arg Arg 210 215 220 Phe Cys Ala Ser Val Leu Gln Arg Gly Gly Ala Arg Pro Ser Pro Pro 225 230 235 240

Val Gly Pro Thr <210> 3767 <211> 969 <212> DNA <213> Felis catus <400> 3767 atggaaacag gaaatgatac acaaatttca gagtttaacc ttctgggatt ttcaaaggga 60 ccagagctgc agcccctcat atttgggctt ttcctctcca tgtacctgat cactgtgttt 120 ggcaacctgc tcatcctcct ggccgtcagc tctgactccc gcctccacac ccccatgtac 180 ttcttcctgg ccaacctgtc ctttgtagac atctgcttca cctccaccac cgtcccgaag 240 atgctctgga acatccagac ccagaccaaa gtcataacct atgaaggctg catcactcag 300 atgtactttt tccttgtctt tgctggattg gacaactttc tactgtctgt gatggcttat 360 gaccggtttg tggccatctg ttaccccctg aactatatgg tcatcatgaa cccccggctc 420 tgtgggctgc tggtcctggt gtcctggatc acgagtgtcc tgcattcctt gttacaaagt 480 tcaatggtgt tgcacctgtc cttctgtaca gaggtagaaa tcccccactt tttctgtgag 540 ctcaatcaga tgatctaact tgcctgctct gacacctttc ttaatgacac ggtgatatat 600 cttgcagctg tgctgttggg tggtgttccc ctggctgggg tcctttactc ttattctaag 660 atagtttcct ccatacgtag gatctcatca gctctgggca agtataaggc attttccacc 720 tgtgcatctc acctctcggt tgtctcctta ttttattgca caagcctagg agtgtacctc 780 agctctgctg ctacccagag ctcccactcg agtgccacag cctcggtgat gtacacggtg 840

Page 4219

069269_0225_SL.TXT gtcacgccca tgctgaaccc cttcatctac agcctgagga acagagacat aaagagggct ctgaaaagaa ttgttggcat tccagcaatg catgggacaa tcgtcctgag gccaaagacg tgcccatga

900

960

969 <210> 3768 <211> 185 <212> PRT <213> Felis catus

<400> 3768 Asp Thr Gln Ile Ser Glu Phe Asn Leu Leu Gly Met Glu 1 Thr Gly Asn 5 10 15 Phe Ser Lys Gly Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 Val Ser Ser Asp Ser Arg Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Thr Lys Val Ile Thr Tyr Glu Gly 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Leu Val Phe Ala Gly Leu Asp Asn 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Tyr 115 120 125 Pro Leu Asn Tyr Met Val Ile Met Asn Pro Arg Leu Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Ile Thr Ser Val Leu His Ser Leu Leu Gln Ser 145 150 155 160

Page 4220

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Ser Met Val Leu His Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175

Phe Phe Cys Glu Leu Asn Gln Met Ile 180 185 <210> 3769 <211> 968 <212> DNA <213> Felis catus <400> 3769 atggaaccag gaaatgattc acaaatttca gaattttttc ttctgggact atcaaaggaa 60 tcagagctgc aactcctcat ttttgggctt ttcctctcca tgtacctgat cactgtgttt 120 ggcaacctgc tcatcctcct ggccgtcagc tctgactccc acctccacac gcccatgtac 180 ttcttcctgg ccaacctgtc ctttgtagac atctgcctca cctccaccac cgtcccgaag 240 atgctctgga acatccagac ccagagcaaa gtcataacct atgcaggctg catcacacag 300 atgtattttt tcctactctt tgctggattg gacaattttc tactgtctgt gatggcctat 360 gaccggttcg tggccatctg tcaacccttg cactacatgc tgatcatgaa acccacctac 420 tgtgggctgc ttgttctggt gtcctggatg atgagcaccc tgaactcctt attacaaacc 480 ttaatgatgt tgtgcctgtc cttctgtaca gaggtggaaa tctcccactt tttctgtgaa 540 atcaatcagg tggtcctgct tgcctgttct gatccctttc ttaatgacat gctgatgtat 600 tttgcagctg gattgttggg tggtgcttcc ctagctggga tcctttactc ttattctaag 660 atagtttctt ttgtatgtgg aatctcatca tctcagggca agtataaggc attttccacc 720 tgtgcgtctc acctctcggt tgtctcccta ttttattgta ctggcctggg agtgtacctt 780 agctctgctg ctacccagag ctcccactcg agtgcaacag cctcagtgat gtatgcagtc 840 gtcacgccca tgctgaaccc cttcatctac agcctgagga acaaagacat aaagagggct 900 ctgaagagaa tcgttggggt tccagtgttg taaaggccaa ttgtcctggg gctgtagata 960 tgccatga 968 <210> 3770 <211> 310

Page 4221

069269_0225_SL.TXT <212> PRT <213> Felis catus

<400> 3770 Phe Leu Leu 15 Gly Met 1 Glu Pro Gly Asn Asp Ser Gln 5 Ile Ser 10 Glu Phe Leu Ser Lys Glu Ser Glu Leu Gln Leu Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Leu Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Ser Lys Val Ile Thr Tyr Ala Gly 85 90 95 Cys Ile Thr Gln Met Tyr Phe Phe Leu Leu Phe Ala Gly Leu Asp Asn 100 105 110 Phe Leu Leu Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys Gln 115 120 125 Pro Leu His Tyr Met Leu Ile Met Lys Pro Thr Tyr Cys Gly Leu Leu 130 135 140 Val Leu Val Ser Trp Met Met Ser Thr Leu Asn Ser Leu Leu Gln Thr 145 150 155 160 Leu Met Met Leu Cys Leu Ser Phe Cys Thr Glu Val Glu Ile Ser His 165 170 175 Phe Phe Cys Glu Ile Asn Gln Val Val Leu Leu Ala Cys Ser Asp Pro 180 185 190

Page 4222

Phe Leu Asn 195 Asp Met Leu Met 069269_0225_SL.TXT Tyr Phe Ala Ala Gly Leu 200 205 Leu Gly Gly Ala Ser Leu Ala Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Phe 210 215 220 Val Cys Gly Ile Ser Ser Ser Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Gly Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser His Ser Ser Ala 260 265 270 Thr Ala Ser Val Met Tyr Ala Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Lys Asp Ile Lys Arg Ala Leu Lys Arg Ile 290 295 300 Val Gly Val Pro Val Leu 305 310

<210> 3771 <211> 963 <212> DNA <213> Felis catus <400> 3771

tcatttatca ctgtttttca ttatttgccc ccagagtttc ttcatgacat ttttcacttc 60 tgcatttctg agggtgtaga ttaaagggtt cagcatggga gagactatcg tacaaaacac 120 agtcacagct ttgtcagagg ggaaggaggt cacgggtctc aggtacagga aggaacaagg 180 tacaaagaat aagatgacaa cggtgacatg agaggcacag gtagacaggg ctttgcgacg 240 cccttcagag ctatgagtcc tcagtgagtg caggatgaca acataagaag caaccagcat 300 agaaaaaatg agcgaacaca gtgatccact gttggcagca atcaggggcc ccaaagtgcg 360 agtgtctgta caggctagct ccagaagagg tattaaatcg cacagaaaat ggtcaataac 420

Page 4223

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attggggaca cagaacggta actggaccat gaacaaaatc tggattcctc catgaagaaa 480 gcctaaaatc ccagccattg ccacgaagaa acgacagaca ggtcgtctca tgatggtcat 540 gtaatgcaag ggcttacaga tggctacata gcggtcatag gccatgacaa ttaacaagac 600 gatctcagct ccagcgaaga aatgttctgc aaagagctga gtcatgcagc cattgaagga 660 gatggtgttc ttctcagaga tcaggtcata gatcattttg ggtgctatgg aagaagagta 720 gaaaccatct ataatagaca agtaggacag gaaaaagtac atgggagaac ccagggctgg 780 gctgatgaag atggtgacgg agatgagcag gttacccgcc agtgtgatca agtaggtgat 840 taacaacaca gcaaataaga atttctgcag ttctggattc tgggtcaagc ccagcaaaat 900 gaattctgtt acattgctca tcctttccat ggattcagct tgggttgtga gcacatggtc 960 cat 963 <210> 3772 <211> 320 <212> PRT <213> Felis catus <400> 3772 Met Asp His Val Leu Thr Thr Gln Ala Glu Ser Met Glu Arg Met Ser 1 5 10 15 Asn Val Thr Glu Phe Ile Leu Leu Gly Leu Thr Gln Asn Pro Glu Leu 20 25 30 Gln Lys Phe Leu Phe Ala Val Leu Leu Ile Thr Tyr Leu Ile Thr Leu 35 40 45 Ala Gly Asn Leu Leu Ile Ser Val Thr Ile Phe Ile Ser Pro Ala Leu 50 55 60 Gly Ser Pro Met Tyr Phe Phe Leu Ser Tyr Leu Ser Ile Ile Asp Gly 65 70 75 80 Phe Tyr Ser Ser Ser Ile Ala Pro Lys Met Ile Tyr Asp Leu Ile Ser 85 90 95 Glu Lys Asn Thr Ile Ser Phe Asn Gly Cys Met Thr Gln Leu Phe Ala

Page 4224

100

069269_0225_SL.TXT 105 110

Glu His Phe 115 Phe Ala Gly Ala Glu Ile Val Leu Leu Ile Val Met Ala 120 125 Tyr Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Met Thr Ile 130 135 140 Met Arg Arg Pro Val Cys Arg Phe Phe Val Ala Met Ala Gly Ile Leu 145 150 155 160 Gly Phe Leu His Gly Gly Ile Gln Ile Leu Phe Met Val Gln Leu Pro 165 170 175 Phe Cys Val Pro Asn Val Ile Asp His Phe Leu Cys Asp Leu Ile Pro 180 185 190 Leu Leu Glu Leu Ala Cys Thr Asp Thr Arg Thr Leu Gly Pro Leu Ile 195 200 205 Ala Ala Asn Ser Gly Ser Leu Cys Ser Leu Ile Phe Ser Met Leu Val 210 215 220 Ala Ser Tyr Val Val Ile Leu His Ser Leu Arg Thr His Ser Ser Glu 225 230 235 240 Gly Arg Arg Lys Ala Leu Ser Thr Cys Ala Ser His Val Thr Val Val 245 250 255 Ile Leu Phe Phe Val Pro Cys Ser Phe Leu Tyr Leu Arg Pro Val Thr 260 265 270 Ser Phe Pro Ser Asp Lys Ala Val Thr Val Phe Cys Thr Ile Val Ser 275 280 285 Pro Met Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Ala Glu Val Lys 290 295 300 Asn Val Met Lys Lys Leu Trp Gly Gln Ile Met Lys Asn Ser Asp Lys

Page 4225

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305 310 315 320 <210> 3773 <211> 928 <212> DNA <213> Felis catus <400> 3773

tccaacatca cagtcttcag gccttctgtg ttgacgctga tagggatccc aggcctagag 60 actgtgcagt gctggattgg gattccattc tgtgtcatgt atctcattgc tatgattgga 120 aactccttgc ttctgatcat catcaggtca gaacgcagcc tccatgagcc catgtacatt 180 ttctaggcat gctgggagtc acagatactt tacttggcac gagcattgtc cccaagatgc 240 ttggaatctt ctggtttcat gtgccagaga tttatttaga ttcttgcttg cttcaaatgg 300 ggctcatcca cacatttcag ggtatagagt caggcatcct gttggccatg gctctggacc 360 attatgtggc catctgttat ccactaagac atgctgccat cttcacccac tgcttagtca 420 cccaaatagc agctgtggta acactcaggg ctgcccttct tgtagcccca tctttagtac 480 tgataaagtt ccggtttcat ttttaccata caaccatcat ctcccactgc tactgtgagc 540 atatggccat tgtgaaactg gctgcagaaa atgcacgagt caatgaattt tatggtttgt 600 ttggggcatt tacagttgca gggttcgacc tcacattcat cactttgtct tatgcacaga 660 tctttttcac agtttttcat ttgccccaga aggaggctcg tttgaaagca ttcaatacgt 720 gcatcgctca catctgtgtc ttctccagct ctacctcctt accttcttct ccttcttcac 780 acataggttt ggtgctcatg ttccccctta tatccacatc cttttttcta gcctctactt 840 gctggtcccc ccgtttctca atccacttgt gtacagtgcc aagaccacgc acatccgcat 900 tcacctggta aagatgttgt attcataa 928

<210> 3774 <211> 61 <212> PRT <213> Felis catus <400> 3774

Ser Asn Ile Thr Val Phe Arg Pro Ser Val Leu Thr Leu Ile Gly Ile 1 5 10 15

Page 4226

069269_0225_SL.TXT Pro Gly Leu Glu Thr Val Gln Cys Trp Ile Gly Ile Pro Phe Cys Val 20 25 30

Met Tyr Leu Ile Ala Met Ile Gly Asn Ser Leu Leu Leu Ile Ile Ile 35 40 45

Arg Ser Glu Arg Ser Leu His Glu Pro Met Tyr Ile Phe 50 55 60

<210> 3775 <211> 926 <212> DNA <213> Felis catus <400> 3775

ttatgaatac aactctttac caggtgaatg tggatctgcg tggtcttggc actgtacaca 60 agcggattga gaaatagggg accagcaagt agaggctaga gaagaggatg tggatataag 120 ggggaaaatg agcaccaaac ctatgtgtga agaaggagaa gaaggcaagg aggtagaact 180 ggaggaagac acagatgtga gcgatgcacg tattgaatgc tttcaaacga gcctccttct 240 ggggcaaacg aaaaactgtg aaaaagatct gtgcataaga caaagtgatg aatgtgaggt 300 cgaaccctgc aactataaat gccccaaaca aaccataaaa ttcactgact tgtgcatttt 360 ctgcagccat tttcacaatg gccatatgct cacagtagca gtgggagatg atggttgtat 420 ggtaaaactg aaaccggcat tttatcagta ctaaagatgg ggctacaaga agggcagccc 480 tgagtgttac cacagctgct atttgggtga ctaagcagtg ggtgaagatg gcagcatgtc 540 ttagtggata acagatggcc acataatggt ccagagccat ggccaacagg atgcctgact 600 ctataccctg aaatgtgtgg atgagcccca tttgaagcaa gcaagaatct aaataaatct 660 ctggcacatg aaaccagaag atccaagcat cttggggaca atgctcgtgc caagtaaagt 720 atctgtgact cccagcatgc ctagaaaatg tacatgggct catggaggct gcgttctgac 780 ctgatgatga tcagaagcaa ggagtttcca atcatagcaa tgagatacat gacacagaat 840 ggaatcccaa tccagcactg cacagtctct aggcctggga tccctatcag cgtcaacaca 900 gaaggcctga agactgtgat gttgga 926

<210> 3776

Page 4227

069269_0225_SL.TXT <211> 61 <212> PRT <213> Felis catus

<400> 3776 Phe Arg Pro Ser Val Leu Thr Leu Ile Gly Ile Ser 1 Asn Ile Thr Val 5 10 15 Pro Gly Leu Glu Thr Val Gln Cys Trp Ile Gly Ile Pro Phe Cys Val 20 25 30 Met Tyr Leu Ile Ala Met Ile Gly Asn Ser Leu Leu Leu Ile Ile Ile 35 40 45 Arg Ser Glu Arg Ser Leu His Glu Pro Met Tyr Ile Phe 50 55 60

<210> 3777 <211> 750 <212> DNA <213> Felis catus <400> 3777 ctatgtattt ttcttagccc ctcgtccttt taggtattgt tcctcttctt ccattgcccc 60 caagatgctg tgtgatatct ttccagagaa acaagtcacc tctctcaggg ttgtaccaca 120 cagatgtggt tctctgcttt ctttgtggta tctgaatgtt tcttcctgac atccatggca 180 catgactggt atttggccat cggtaagccc ttgttgcatg ccctcattat gtcccagagg 240 gtctctgtgc agctggttgt aaggccttat ggcatggctc ttctaaggag catgacctat 300 atgacattga ctttttgctt acccttgtgt ggtccaaata tcatcaatca ttttttctgt 360 gatatttccc atctgctttc tcttacatgt gcagacactt ccgtgactca acttacattt 420 tctttttggc tggatctaca ggaatcttca gtggcctgat catgatggtc tcccatgttt 480 gcatcctggt ggccatctgg aagatccaga ttgctcatgg gaggcagaac gctttgtcca 540 cctgctcctc tcacctggta gttgtctcca tcctgtatgg gactcttttc ttatctctgt 600 tcggcctggc tcaagtccct ccctggatct caataaagtg atttctctgt tgtacactgt 660 ggtgatgccc atgtggaacc ccctcgtcta cagcttgggg aataaggagg taagatacac 720 atttgggact aaatttgaaa ggaaaacttc 750

Page 4228

069269_0225_SL.TXT <210> 3778 <211> 72 <212> PRT <213> Felis catus <400> 3778

Met 1 Gln Gln Gly Leu Thr Asp Gly Gln Ile Pro Val Met Cys His Gly 5 10 15 Cys Gln Glu Glu Thr Phe Arg Tyr His Lys Glu Ser Arg Glu Pro His 20 25 30 Leu Cys Gly Thr Thr Leu Arg Glu Val Thr Cys Phe Ser Gly Lys Ile 35 40 45 Ser His Ser Ile Leu Gly Ala Met Glu Glu Glu Glu Gln Tyr Leu Lys 50 55 60 Gly Arg Gly Ala Lys Lys Asn Thr

65 70 <210> 3779 <211> 939 <212> DNA <213> Felis catus <400> 3779

atgtccactt ccaacatcac agtcttcatg ccttctgtgt tgacgctgat agggatccca 60 ggcctagaga ctgtgcagtg ctggattggg attccattct gtgtcatgta tctcattgcc 120 atcattggaa actcaatgct tctgatcatc atcaggtcag agcgcagcct ccatgagccc 180 atgtacattt tcataggcat gctgggagtc acagatattg cacttgctac caccattatg 240 cccaagatgc ttggaatttt ctggtttcat gtgccagaca tttattttga ttcctgtttg 300 cttcaaatgt ggctcatcca cacatttcag tgcatagagt caggccttct gttggccatg 360 gctgtggacc gttatgtggc catctgttat ccactaagac atgctgtcat catcacgcac 420 cgccttgtca cccagatagg ggcagtgata acactcaggg cagctttcct agtagccccc 480 tgcctaatac tgataaagtt ccggtttcag ttttaccata caaccatcat ctcccactct 540

Page 4229

069269_0225_SL.TXT

tattgtgagc atatggccat tgtgaaactg gctgcatcag atgtgcgggt caacaaaatt 600 tatggcttgt ttgcggcatt caccgttgca gtgtttgacc tcacattcat cactttgtct 660 tatgcacaga tcttttccac agtttttcgt ttgccccaga aggaggctcg gttgaaagca 720 ttcaatacgt gcatcgctca catatgcgtc ttcctcccgt tctacctcct tgccttcttc 780 tccttcttca cacataggtt tggtgctcat gttcccgctt atatccacat cctcttttct 840 agcctctact tgctggtccc cccatttctc aatccacttg tctatggtgc caagaccaag 900 cagatccgca ttcacctggt aaggatgctc tattcataa 939

<210> 3780 <211> 312 <212> PRT <213> Felis catus <400> 3780

Met Ser Thr Ser Asn Ile Thr Val Phe Met Pro Ser Val Leu Thr Leu 1 5 10 15 Ile Gly Ile Pro Gly Leu Glu Thr Val Gln Cys Trp Ile Gly Ile Pro 20 25 30 Phe Cys Val Met Tyr Leu Ile Ala Ile Ile Gly Asn Ser Met Leu Leu 35 40 45 Ile Ile Ile Arg Ser Glu Arg Ser Leu His Glu Pro Met Tyr Ile Phe 50 55 60 Ile Gly Met Leu Gly Val Thr Asp Ile Ala Leu Ala Thr Thr Ile Met 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Val Pro Asp Ile Tyr Phe 85 90 95 Asp Ser Cys Leu Leu Gln Met Trp Leu Ile His Thr Phe Gln Cys Ile 100 105 110 Glu Ser Gly Leu Leu Leu Ala Met Ala Val Asp Arg Tyr Val Ala Ile 115 120 125

Page 4230

069269_0225_SL.TXT

Cys Tyr Pro 130 Leu Arg His Ala Val Ile Ile Thr His Arg Leu Val Thr 135 140 Gln Ile Gly Ala Val Ile Thr Leu Arg Ala Ala Phe Leu Val Ala Pro 145 150 155 160 Cys Leu Ile Leu Ile Lys Phe Arg Phe Gln Phe Tyr His Thr Thr Ile 165 170 175 Ile Ser His Ser Tyr Cys Glu His Met Ala Ile Val Lys Leu Ala Ala 180 185 190 Ser Asp Val Arg Val Asn Lys Ile Tyr Gly Leu Phe Ala Ala Phe Thr 195 200 205 Val Ala Val Phe Asp Leu Thr Phe Ile Thr Leu Ser Tyr Ala Gln Ile 210 215 220 Phe Ser Thr Val Phe Arg Leu Pro Gln Lys Glu Ala Arg Leu Lys Ala 225 230 235 240 Phe Asn Thr Cys Ile Ala His Ile Cys Val Phe Leu Pro Phe Tyr Leu 245 250 255 Leu Ala Phe Phe Ser Phe Phe Thr His Arg Phe Gly Ala His Val Pro 260 265 270 Ala Tyr Ile His Ile Leu Phe Ser Ser Leu Tyr Leu Leu Val Pro Pro 275 280 285 Phe Leu Asn Pro Leu Val Tyr Gly Ala Lys Thr Lys Gln Ile Arg Ile 290 295 300

His Leu Val Arg Met Leu Tyr Ser 305 310 <210> 3781 <211> 933 <212> DNA

Page 4231

069269_0225_SL.TXT <213> Felis catus <400> 3781

attggcctgt aagggtctct ttcccaaaga atgctttcag agcccttttc atgtctttgt 60 tcctcaagct gtagatgaag gggttcagca tgggcgtgac caccgtgtac atcaccgagg 120 ctgtggcact tgaccgtgag ctgtgggtag cagcagagct aaggtacacg ccgagcatcg 180 tacaataaaa taaggagaca accgatagat gagatgcaca ggtagaaaat gctttacact 240 ttccctgagc tgatgagatc cgacatatgg aggaaactat cttagagtaa gagtaaagga 300 tcccaatgaa gggaccacca gccaacaaga cagctgcaag atacatcacc acgttattaa 360 gaaaggtatc agaacaggcc agttggagca tctgattaag ttcacaaaaa aagtggggga 420 tatgcaagtg tgtacagaag gacagccgca acatcattaa actttgtaac agggaattca 480 ggacacacgt gatcaaggac accacaacca gcagcccaca gagccggggg ttcatgatga 540 tcgtgtagtg cagggggtga cagatggcca caaaccggtc ataggccatc acactcagca 600 gaaagatatc caacacacca aagagtatga aaaaataaat ctgtgtgatg cagtcctcat 660 aggttatgac tttgctctga gtccggatgt tcaccagcat cttcgggacg gtggtggagg 720 tgaagcagat gtctacaaag gacaggttgg ctaggaagaa gtacatgggc gtgtggaggt 780 tggggtctgt gctgatggcc aagatgatga gcaggttgcc aaacacagtg atcaggtaca 840 tggagaggaa aagcccaaat atgaggggct gcattcctgg ttcctctgaa aatcccagaa 900 gaagaaactt tgaaaatttt gtttcattgc ttg 933

<210> 3782 <211> 311 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (311)..(311) <223> Any amino acid <400> 3782

Ser Asn Glu Thr Lys Phe Ser Lys Phe Leu Leu Leu Gly Phe Ser Glu 1 5 10 15

Page 4232

Glu Pro Gly Met 20 Gln Pro Leu 069269_0225_SL.TXT Ile Phe Gly Leu Phe Leu 25 Ser 30 Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Ile Leu Ala Ile Ser Thr 35 40 45 Asp Pro Asn Leu His Thr Pro Met Tyr Phe Phe Leu Ala Asn Leu Ser 50 55 60 Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys Met Leu Val 65 70 75 80 Asn Ile Arg Thr Gln Ser Lys Val Ile Thr Tyr Glu Asp Cys Ile Thr 85 90 95 Gln Ile Tyr Phe Phe Ile Leu Phe Gly Val Leu Asp Ile Phe Leu Leu 100 105 110 Ser Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His Pro Leu His 115 120 125 Tyr Thr Ile Ile Met Asn Pro Arg Leu Cys Gly Leu Leu Val Val Val 130 135 140 Ser Leu Ile Thr Cys Val Leu Asn Ser Leu Leu Gln Ser Leu Met Met 145 150 155 160 Leu Arg Leu Ser Phe Cys Thr His Leu His Ile Pro His Phe Phe Cys 165 170 175 Glu Leu Asn Gln Met Leu Gln Leu Ala Cys Ser Asp Thr Phe Leu Asn 180 185 190 Asn Val Val Met Tyr Leu Ala Ala Val Leu Leu Ala Gly Gly Pro Phe 195 200 205 Ile Gly Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser Ile Cys Arg 210 215 220

Page 4233

Ile 225 Ser Ser Ala Gln Gly 230 Lys 069269_0225_SL.TXT Cys Ala Ser 240 Cys Lys Ala Phe Ser Thr 235 His Leu Ser Val Val Ser Leu Phe Tyr Cys Thr Met Leu Gly Val Tyr 245 250 255 Leu Ser Ser Ala Ala Thr His Ser Ser Arg Ser Ser Ala Thr Ala Ser 260 265 270 Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe Ile Tyr Ser 275 280 285 Leu Arg Asn Lys Asp Met Lys Arg Ala Leu Lys Ala Phe Phe Gly Lys 290 295 300 Glu Thr Leu Thr Gly Gln Xaa 305 310

<210> 3783 <211> 968 <212> DNA <213> Felis catus <400> 3783

atggaaccag gaaatattac acggatatcg aaatttcttc tcctgggatt ttcagtgaga 60 ccagaactgc agcccctcat atttgggctt ttcctctcca tgtacctgat cactgtgttt 120 gggaacctgc tcatcctcct ggccgtcagc tctgactccc acctccacac ccccatgtac 180 ttcttcctcg ccaacctgtc ctttgtagac atctgcttca cctccaccac cgtcccgaag 240 atgctctgga acatccagac ccagaccaaa gtcataacct atgaggactg tatcacacaa 300 atgaactttt tcgtaacctt tgcagggatg gacgactttc tcctggctgt gatggcctat 360 gacaggtttg tggccatctg tcaccctctg cactacatgg tcatcatgag cccctggctc 420 tgtgggctgc tggttctgct gtcctggatc acgagtgtcc tgtattcctt ggtacacagt 480 tcaatggtgt tgcacctgtc cttctgtaca gaggtagaga tcccccactt tttctgtgaa 540 ctcaatcaga tgatccaact tgcctgttct gacacctttc ttaataacgt ggtgatgtat 600 cttgcagcta tgctgctggg tggtggtctg cttgtctgga tcctttactc ttattctaag 660

Page 4234

069269_0225_SL.TXT atagtttcct ccatacgtgg gatctcatca gctcaaggca agtataaagc attttctacc tgtgcatctc acctctcggt tgtctcctta ttttattgtg caagcctagg tgtgtacctt agctctgctg ctacccagag ctcacggtca agtgccacag cctcggtgat gtacacggtg gtcacgccca tgctgaaccc cttcatctac agcctgagga acagagacat aaagagggct ctgaaaagaa tcgttgggat ccagtgatat aagaaccaat catccaaagg ctgaagacat gcccatga

720

780

840

900

960

968 <210> 3784 <211> 308 <212> PRT <213> Felis catus

<400> 3784 Ile Thr Arg Ile Ser Lys Phe Leu Leu Leu Gly Met 1 Glu Pro Gly Asn 5 10 15 Phe Ser Val Arg Pro Glu Leu Gln Pro Leu Ile Phe Gly Leu Phe Leu 20 25 30 Ser Met Tyr Leu Ile Thr Val Phe Gly Asn Leu Leu Ile Leu Leu Ala 35 40 45 Val Ser Ser Asp Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Ala 50 55 60 Asn Leu Ser Phe Val Asp Ile Cys Phe Thr Ser Thr Thr Val Pro Lys 65 70 75 80 Met Leu Trp Asn Ile Gln Thr Gln Thr Lys Val Ile Thr Tyr Glu Asp 85 90 95 Cys Ile Thr Gln Met Asn Phe Phe Val Thr Phe Ala Gly Met Asp Asp 100 105 110 Phe Leu Leu Ala Val Met Ala Tyr Asp Arg Phe Val Ala Ile Cys His 115 120 125

Pro Leu His Tyr Met Val Ile Met Ser Pro Trp Leu Cys Gly Leu Leu Page 4235

069269_0225_SL.TXT

130 135 140

Val Leu Leu Ser 145 Trp Ile Thr Ser Val Leu Tyr Ser Leu Val His Ser 160 150 155 Ser Met Val Leu His Leu Ser Phe Cys Thr Glu Val Glu Ile Pro His 165 170 175 Phe Phe Cys Glu Leu Asn Gln Met Ile Gln Leu Ala Cys Ser Asp Thr 180 185 190 Phe Leu Asn Asn Val Val Met Tyr Leu Ala Ala Met Leu Leu Gly Gly 195 200 205 Gly Leu Leu Val Trp Ile Leu Tyr Ser Tyr Ser Lys Ile Val Ser Ser 210 215 220 Ile Arg Gly Ile Ser Ser Ala Gln Gly Lys Tyr Lys Ala Phe Ser Thr 225 230 235 240 Cys Ala Ser His Leu Ser Val Val Ser Leu Phe Tyr Cys Ala Ser Leu 245 250 255 Gly Val Tyr Leu Ser Ser Ala Ala Thr Gln Ser Ser Arg Ser Ser Ala 260 265 270 Thr Ala Ser Val Met Tyr Thr Val Val Thr Pro Met Leu Asn Pro Phe 275 280 285 Ile Tyr Ser Leu Arg Asn Arg Asp Ile Lys Arg Ala Leu Lys Arg Ile

290 295 300

Val Gly Ile Gln 305 <210> 3785 <211> 939 <212> DNA <213> Felis catus

Page 4236

069269_0225_SL.TXT <400> 3785

ttatgaatag agcatcttta ccaggtgaat gcggatctgc ttggtcttgg caccatagac 60 aagtggattg agaaatgggg ggaccagcaa gtagaggcta gaaaagagga tgtggatata 120 agggggaaca tgagcaccaa acctatgtgt gaagaaggag aagaaggcaa ggaggtagaa 180 cgggaggaag acgcatatgt gagcgatgca cgtattgaat gctttcaacc gagcctcctt 240 ctggggcaaa cgaaaaactg tggaaaagat ctgtgcataa gacaaagtga tgaatgtgag 300 gtcaaacact gcaacggtga atgccacaaa caagccataa attttgttga cccgcacatc 360 tgatgcagcc agtttcacaa tggccatatg ctcacaataa gagtgggaga tgatggttgt 420 atggtaaaac tgaaaccgga actttatcag tattaggcag ggggctacta ggaaagctgc 480 cctgagtgtt accactgccc ctatctgggt gacaaggtgg tgcgtgacga tggcagcatg 540 tcttagtgga taacagatgg ccacataacg gtccacagcc atggccaaca gaaggcctga 600 ctctatgcac tgaaatgtgt ggatgagcca catttgaagc aaacaggaat caaaataaat 660 gtctggcaca tgaaaccaga aaattccaag catcttgggc ataatggtgg tagcaagtgc 720 aatatctgtg actcccagca tgcctacgaa aatgtacatg ggctcatgga ggctgtgctc 780 tgacctgatg atgatcagaa gcattgagtt tccaatgatg gcaatgagat acatgacaca 840 gaatggaatc ccaatccagc actgcacagt ctctaggcct gggatcccta tcagtgtcaa 900 cacagaaggc atgaagactg tgatgttgga agtggacat 939

<210> 3786 <211> 312 <212> PRT <213> Felis catus <400> 3786

Met 1 Ser Thr Ser Asn Ile Thr Val Phe Met Pro Ser Val Leu Thr Leu 5 10 15 Ile Gly Ile Pro Gly Leu Glu Thr Val Gln Cys Trp Ile Gly Ile Pro 20 25 30 Phe Cys Val Met Tyr Leu Ile Ala Ile Ile Gly Asn Ser Met Leu Leu 35 40 45

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Ile Ile 50 Ile Arg Ser Glu His Ser 55 Leu His Glu Pro Met Tyr Ile 60 Phe Val Gly Met Leu Gly Val Thr Asp Ile Ala Leu Ala Thr Thr Ile Met 65 70 75 80 Pro Lys Met Leu Gly Ile Phe Trp Phe His Val Pro Asp Ile Tyr Phe 85 90 95 Asp Ser Cys Leu Leu Gln Met Trp Leu Ile His Thr Phe Gln Cys Ile 100 105 110 Glu Ser Gly Leu Leu Leu Ala Met Ala Val Asp Arg Tyr Val Ala Ile 115 120 125 Cys Tyr Pro Leu Arg His Ala Ala Ile Val Thr His His Leu Val Thr 130 135 140 Gln Ile Gly Ala Val Val Thr Leu Arg Ala Ala Phe Leu Val Ala Pro 145 150 155 160 Cys Leu Ile Leu Ile Lys Phe Arg Phe Gln Phe Tyr His Thr Thr Ile 165 170 175 Ile Ser His Ser Tyr Cys Glu His Met Ala Ile Val Lys Leu Ala Ala 180 185 190 Ser Asp Val Arg Val Asn Lys Ile Tyr Gly Leu Phe Val Ala Phe Thr 195 200 205 Val Ala Val Phe Asp Leu Thr Phe Ile Thr Leu Ser Tyr Ala Gln Ile 210 215 220 Phe Ser Thr Val Phe Arg Leu Pro Gln Lys Glu Ala Arg Leu Lys Ala 225 230 235 240 Phe Asn Thr Cys Ile Ala His Ile Cys Val Phe Leu Pro Phe Tyr Leu 245 250 255

Page 4238

Leu Ala Phe Phe 260 Ser Phe Phe 069269_0225_SL.TXT Thr His Arg Phe Gly Ala 265 His 270 Val Pro Pro Tyr Ile His Ile Leu Phe Ser Ser Leu Tyr Leu Leu Val Pro Pro 275 280 285 Phe Leu Asn Pro Leu Val Tyr Gly Ala Lys Thr Lys Gln Ile Arg Ile 290 295 300 His Leu Val Lys Met Leu Tyr Ser

305 310 <210> 3787 <211> 942 <212> DNA <213> Felis catus <400> 3787

atgtctgttc aacctgattc caaaatcagt aactccacct ttctccttac gggtttccct 60 ggcctggaac gggaatatcc ttggctctcc attcctttct cctgtatcta tgctatggta 120 ctcttaggga attgcctggt gttgcatgtg atccggacgg agcccagcct acatgagccc 180 atgttctact tcctggccat gttggccctc actgacctgt gcatggggct gtccacagtg 240 cacacggtgc tcgggatcct gtggggcttg agcagggaag tcagcctgga tgcctgcatt 300 gcccaaactt acttcatcca tggtctgtcc ctcacagagt ctggagtcct tcttgccatg 360 gcctttgatc gctttactgc catctgcaat cctctgagat atacatccat cctcaccaat 420 atgagaatca tcaccattgg tgtggccatt ttagggagga gtttcctgtt cattaccgct 480 cccattgtcc gcctaaagtt cttcgattac tgccatcctc atatcctctc ccattccttc 540 tgcctgcacc aagacttact tcggctcgcc tgctccgaca tccgcttcaa cagcttctat 600 gcgttagccc tggtgatctg cacactcttt ttggattcgg tgctcattct catctcctac 660 atcgcgatcc tgcattcagt cttgactatt gcatcccggg atgagcggct caagtccttg 720 aagacctgtg tctcccacat ctgtgctgtt ctggttttct atatcccaat tattgggttg 780 actatggtgc accgctttgg aaagcacctc tctcctgtgg tccatgtcct catgggcaat 840 atctatatcc ttttcccacc cttgatgaac cctatcatct acagtgtcaa aacccaacaa 900

Page 4239

942

069269_0225_SL.TXT atacgtagca ggatccagag atggttcgct aaacaaaact ga <210> 3788 <211> 313 <212> PRT <213> Felis catus <400> 3788

Met 1 Ser Val Gln Pro 5 Asp Ser Lys Ile Ser Asn Ser Thr Phe Leu Leu 10 15 Thr Gly Phe Pro Gly Leu Glu Arg Glu Tyr Pro Trp Leu Ser Ile Pro 20 25 30 Phe Ser Cys Ile Tyr Ala Met Val Leu Leu Gly Asn Cys Leu Val Leu 35 40 45 His Val Ile Arg Thr Glu Pro Ser Leu His Glu Pro Met Phe Tyr Phe 50 55 60 Leu Ala Met Leu Ala Leu Thr Asp Leu Cys Met Gly Leu Ser Thr Val 65 70 75 80 His Thr Val Leu Gly Ile Leu Trp Gly Leu Ser Arg Glu Val Ser Leu 85 90 95 Asp Ala Cys Ile Ala Gln Thr Tyr Phe Ile His Gly Leu Ser Leu Thr 100 105 110 Glu Ser Gly Val Leu Leu Ala Met Ala Phe Asp Arg Phe Thr Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Thr Ser Ile Leu Thr Asn Met Arg Ile Ile 130 135 140 Thr Ile Gly Val Ala Ile Leu Gly Arg Ser Phe Leu Phe Ile Thr Ala 145 150 155 160 Pro Ile Val Arg Leu Lys Phe Phe Asp Tyr Cys His Pro His Ile Leu 165 170 175

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Ser His Ser Phe Cys 180 Leu His Gln Asp Leu Leu Arg Leu Ala Cys Ser 185 190 Asp Ile Arg Phe Asn Ser Phe Tyr Ala Leu Ala Leu Val Ile Cys Thr 195 200 205 Leu Phe Leu Asp Ser Val Leu Ile Leu Ile Ser Tyr Ile Ala Ile Leu 210 215 220 His Ser Val Leu Thr Ile Ala Ser Arg Asp Glu Arg Leu Lys Ser Leu 225 230 235 240 Lys Thr Cys Val Ser His Ile Cys Ala Val Leu Val Phe Tyr Ile Pro 245 250 255 Ile Ile Gly Leu Thr Met Val His Arg Phe Gly Lys His Leu Ser Pro 260 265 270 Val Val His Val Leu Met Gly Asn Ile Tyr Ile Leu Phe Pro Pro Leu 275 280 285 Met Asn Pro Ile Ile Tyr Ser Val Lys Thr Gln Gln Ile Arg Ser Arg 290 295 300 Ile Gln Arg Trp Phe Ala Lys Gln Asn 305 310

<210> 3789 <211> 953 <212> DNA <213> Felis catus <400> 3789 atgacagcac atcaaaatgg caccatctcc tttgagattt cagacttcct cctgaattgt tttgtcaggt cccccagctg gaagctctgg ttgtccgtgc cactcagcct cctctttctc ctgggccaat ggggagccca atagtgttct cctgatcacc atctggctgg aagcctctct gcatgaaccc atgtattacc tgctcagttt cctgtcacta ctggatatcg tgctctgcct cactgtcatc cccaaggtcc tggccatctt ctggtttgac ctcaagtcca tcagcttcta Page 4241

120

180

240

300

069269_0225_SL.TXT

tgcctgcttc ctccagatgt acatcatgaa ttgcttcctt ggcatggagt cgtgcacatt 360 catggtcatg gcctatgacc gctatgtagc catctgccac ccactgaggt acccatccat 420 catcactgac cattttgtag ccaaagctgc catttttact ttggccagaa atgcacttct 480 tactatattc attcccatcc tctctgcacg gctccattat tgtggaaaaa atataattga 540 taattgtatc tgtgccaatc tctctgtgtc caagctctcc tgtgataata ttgcccttaa 600 cagaattttc cagttaactg tggcctggac tctactgggc tctgacctga ccctcatcat 660 cttctcctat accttcatcc tacgagccgt tcttagactt aagacaaaag ggtcagctgc 720 caaagctctg aacacttgtg gctctcactt catcctcatc ctcttcttca gcaccatcct 780 gctggttttt gttttcaccc acattgccaa gaaaaaaatt tcccctgata tccctgtctt 840 acttaatgtg ttacaccatg taattcctgc agctctcaac cccattgtct atggggtacg 900 aactcaggag attaaagagg ggattaggaa attactgagg agggcaagag aga 953

<210> 3790 <211> 255 <212> PRT <213> Felis catus <220>

<221> MOD_RES <222> (255)..(255) <223> Any amino acid <400> 3790

Met Tyr Tyr Leu Leu Ser Phe Leu Ser Leu Leu Asp Ile Val Leu Cys 1 5 10 15 Leu Thr Val Ile Pro Lys Val Leu Ala Ile Phe Trp Phe Asp Leu Lys 20 25 30 Ser Ile Ser Phe Tyr Ala Cys Phe Leu Gln Met Tyr Ile Met Asn Cys 35 40 45 Phe Leu Gly Met Glu Ser Cys Thr Phe Met Val Met Ala Tyr Asp Arg 50 55 60

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Tyr 65 Val Ala Ile Cys His Pro Leu Arg Tyr Pro Ser Ile Ile Thr Asp 70 75 80 His Phe Val Ala Lys Ala Ala Ile Phe Thr Leu Ala Arg Asn Ala Leu 85 90 95 Leu Thr Ile Phe Ile Pro Ile Leu Ser Ala Arg Leu His Tyr Cys Gly 100 105 110 Lys Asn Ile Ile Asp Asn Cys Ile Cys Ala Asn Leu Ser Val Ser Lys 115 120 125 Leu Ser Cys Asp Asn Ile Ala Leu Asn Arg Ile Phe Gln Leu Thr Val 130 135 140 Ala Trp Thr Leu Leu Gly Ser Asp Leu Thr Leu Ile Ile Phe Ser Tyr 145 150 155 160 Thr Phe Ile Leu Arg Ala Val Leu Arg Leu Lys Thr Lys Gly Ser Ala 165 170 175 Ala Lys Ala Leu Asn Thr Cys Gly Ser His Phe Ile Leu Ile Leu Phe 180 185 190 Phe Ser Thr Ile Leu Leu Val Phe Val Phe Thr His Ile Ala Lys Lys 195 200 205 Lys Ile Ser Pro Asp Ile Pro Val Leu Leu Asn Val Leu His His Val 210 215 220 Ile Pro Ala Ala Leu Asn Pro Ile Val Tyr Gly Val Arg Thr Gln Glu 225 230 235 240 Ile Lys Glu Gly Ile Arg Lys Leu Leu Arg Arg Ala Arg Glu Xaa 245 250 255

<210> 3791 <211> 665 <212> DNA <213> Felis catus

Page 4243

069269_0225_SL.TXT <400> 3791

agacctcaag gaattgggtc ccttgttctt cctggtgttt ggcattgtct acctagccac 60 catttctggg aatcttctcc tcgtggtcct ggtgagcact cagcggggac tccagacacc 120 aatgtacttc tttctggtga acctctcatg cctagaggtc tgttatacat ccaacattgt 180 gcccatgatg ctggtggact tgttaagaaa taacagagtg atctccatgg caggttgtgt 240 tatgcagctc tgcttctctg gggctctggg cagcactgaa tgttgtcttc tggcagcgac 300 gtcatatgac tgctacctgg ccatctgcca gcccttgcac gatccaacat taatgcatgg 360 aacgatatgt gtagggctag taattggttc atgggttagt ggcttcacag tggcagctgc 420 attccaggct gctatggtac ccagtttgac cttctgtgat ggcaatgaga ttaaccattt 480 cttctgtgac tgaaacctct gcagaagctc tcctgctcag atccccatct ggtcaacctg 540 gactaacagt gttggttact ctggcccctt tggactaacc ctagtctctt actggaagat 600 tctttccatg gtcttgcata taacttccat gactggtagg aagaagacct tctccacttg 660

ttctt 665 <210> 3792 <211> 163 <212> PRT <213> Felis catus <400> 3792

Asp Leu Lys Glu Leu Gly Pro Leu Phe Phe Leu Val Phe Gly Ile Val 1 5 10 15 Tyr Leu Ala Thr Ile Ser Gly Asn Leu Leu Leu Val Val Leu Val Ser 20 25 30 Thr Gln Arg Gly Leu Gln Thr Pro Met Tyr Phe Phe Leu Val Asn Leu 35 40 45 Ser Cys Leu Glu Val Cys Tyr Thr Ser Asn Ile Val Pro Met Met Leu 50 55 60 Val Asp Leu Leu Arg Asn Asn Arg Val Ile Ser Met Ala Gly Cys Val 65 70 75 80

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Met Gln Leu Cys Phe Ser Gly Ala 85 Leu Ala Ala Thr Ser Tyr Asp Cys 100 His Asp Pro Thr Leu Met His Gly 115 120 Gly Ser Trp Val Ser Gly Phe Thr 130 135 Met Val Pro Ser Leu Thr Phe Cys 145 150 Phe Cys Asp

Leu Gly 90 Ser Thr Glu Cys Cys 95 Leu Tyr 105 Leu Ala Ile Cys Gln 110 Pro Leu Thr Ile Cys Val Gly 125 Leu Val Ile Val Ala Ala Ala 140 Phe Gln Ala Ala Asp Gly Asn 155 Glu Ile Asn His Phe 160

<210> 3793 <211> 719 <212> DNA <213> Felis catus <400> 3793 ttgtggcatg ccaacttggg tcttccacat tatagcctga tggaattgta tttgttgggc tggaggtctc aagggcttta ggctgtaagg gttccctgga agagggagaa gcagtggcct ctgagcagga tgggcaccat gacaaaggag tcaggatcag aacaggccag atttagtaga tcataggctg tacaggatgg cagctggaaa aatccatcca gccaaggccc acttgcaaac gggtactgga gagagctgca gatagcaagg aaagcactca actacagcta atgaactgaa agctgcctca ggatctgaga gagggtctgc tttctcctaa aagacatcta tatatggtgg aaactcaact ttaccaagca aggattaacc cccaagggag ggtccctgct ctgctggcca gaatccccaa gtacttcatc tagtgcctga gccaggagga aagtggcctt ctccaccacc ggatccaggt cactgaagaa gtggccattc gtcatgagga cagtgaccac aggggttagg ataatgcacg tgtggaggtt catgagggat tagtggtcag aaggcacggc ctggcagcac ggagaactgg gccacacaac ctgcaaaaga agcatcttag gggcaacgga agtagtggac

120

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069269_0225_SL.TXT cagatgtcaa ggaaggaaaa attgaacgaa aagaagtaca tgggggtgtg gaggctgag 719 <210> 3794 <211> 53 <212> PRT <213> Felis catus <400> 3794

Leu Ser Leu His Thr Pro Met Tyr Phe Phe Ser Phe Asn Phe Ser Phe 1 5 10 15 Leu Asp Ile Trp Ser Thr Thr Ser Val Ala Pro Lys Met Leu Gln Thr 20 25 30 Leu Ser Gln Ile Leu Arg Gln Leu Leu Leu Gln Val Val Trp Pro Ser 35 40 45 Ser Pro Ser Val His

<210> 3795 <211> 905 <212> DNA <213> Felis catus <400> 3795

cttcttaaga acattcctaa gtgtttcctt cacatctttg ttcctcagac tatagatcat 60 ggggttaagt aagcatggaa atgaccactg tgtaggatac agacaccagc ctgtccctgc 120 ctagcaagta ctcagaggat gggcgcaagt aaatgaatgc tgtggttcca tagtataggc 180 tgacagaagt caggtgaaga agcacaagtg gagaatgttt tgtgtttacc cttggctgag 240 ggaattctga tgataaccaa gaaggcatat gcgtaggaga ccaggactat tgtcagggac 300 acagacacat taaagccacc acaggcaaag aggagaagct ggagtatctg tgtgtcagag 360 caggagagtt ttaaaagggg aggaatatca cagaaataat gcgtgatgac atgggattta 420 cagaaggtca gataaaaggt tgtgctagta aggagcacca tgttcatcag gcccactgca 480 tagctggcac ccacaagctg caaacagagc cttggggaca tgatgatatg gtagagcaga 540 gggctgcaga tggccacatg gcggtcatag gccatggaag ccaggaggaa gaactcagtg 600

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acagcaaaga acacaaaaca gcttgtctgt accacacaac cagagaagga gattgtttgg 660 caaccagaga agaaacccat caacattttt ggaactgtga ctgaagaata acagaagtca 720 ataaaggaca aattgctgag gaagaaatac atgggagtgt agagggctga ccacaatgag 780 ggcaaggagg cccaggtttc ccacaactgt gattgcatag atcaggagga agagggcaaa 840 gaagataggc tgaaggtgag gatcgtcagt gaggcccaca gtgaagaatt cactcaactt 900

gctgg 905 <210> 3796 <211> 61 <212> PRT <213> Felis catus

<400> 3796 Glu Phe 5 Phe Thr Val Gly Leu Thr Asp Asp Pro His Ser 1 Lys Leu Ser 10 15 Leu Gln Pro Ile Phe Phe Ala Leu Phe Leu Leu Ile Tyr Ala Ile Thr 20 25 30 Val Val Gly Asn Leu Gly Leu Leu Ala Leu Ile Val Val Ser Pro Leu 35 40 45 His Ser His Val Phe Leu Pro Gln Gln Phe Val Leu Tyr 50 55 60

<210> 3797 <211> 924 <212> DNA <213> Felis catus <400> 3797 ttagggactc tgcttcaata ttttccataa ggcagctttt acttcctggt ttctcaagct 60 gtagatgaga ggatttaaca tggggatcac cattgtataa aacactgaaa ccatctgatt 120 tcctgcttgg gatccacgtt gtgagggctg caagtaagtg tacatagttg ttccatagta 180 caggccaaca gcagtcatgt gggaagcaca ggtagagaaa gctttttgtt tgctggaagc 240 tgaaggaatt cccaggatag tcattaggac agacatgtag gagacaagga tcaccacaat 300 ggaggtgacc agggtgaatc ccccacagcc aacaaccagt atctgcgtga tccaggggtc 360

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tgagcaagcc agtgccaaca gtggagggat gtcacagaag aagtggggaa ggacacgtgg 420 ttggcagaat gacagttgtg tgatggaagc tgtcacagaa accatgttaa ctaacccccc 480 aaagtagcat cctgctacca agaggagaca acggactcta gacattgtga catggtagag 540 caatgggtga cagatggcag tgtatcggtc ataggccatg gaagccaaaa gattgcattc 600 agcagaggca aagataatga acaagcccat ttgagtcaca cacccaagga aagaaacagc 660 ctgcaactta gatagcaaat ttgctaaagt ctttgggatc gtgatggaag agaaacagac 720 atcaagaagg gacagattag agagaaaaaa gtacatggga gtatgaaggc agggactgac 780 tctgatcagg atcaccaggc ctagattccc caacatagtg acagtataaa caataagtaa 840 gactccaaat agcagcactc caagctgagg gttgtctgtc aagccaagaa gaatgaagtc 900 cgtcaccatg gatgaattct ccat 924

<210> 3798 <211> 307 <212> PRT <213> Felis catus

<400> 3798 Ser Met 5 Val Thr Asp Phe Ile Leu Leu Gly Leu Thr Met Glu 1 Asn Ser 10 15 Asp Asn Pro Gln Leu Gly Val Leu Leu Phe Gly Val Leu Leu Ile Val 20 25 30 Tyr Thr Val Thr Met Leu Gly Asn Leu Gly Leu Val Ile Leu Ile Arg 35 40 45 Val Ser Pro Cys Leu His Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu 50 55 60 Ser Leu Leu Asp Val Cys Phe Ser Ser Ile Thr Ile Pro Lys Thr Leu 65 70 75 80 Ala Asn Leu Leu Ser Lys Leu Gln Ala Val Ser Phe Leu Gly Cys Val 85 90 95

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Thr Gln Met Gly 100 Leu Phe Ile 069269_0225_SL.TXT Ile Phe Ala Ser Ala Glu 105 Cys 110 Asn Leu Leu Ala Ser Met Ala Tyr Asp Arg Tyr Thr Ala Ile Cys His Pro Leu 115 120 125 Leu Tyr His Val Thr Met Ser Arg Val Arg Cys Leu Leu Leu Val Ala 130 135 140 Gly Cys Tyr Phe Gly Gly Leu Val Asn Met Val Ser Val Thr Ala Ser 145 150 155 160 Ile Thr Gln Leu Ser Phe Cys Gln Pro Arg Val Leu Pro His Phe Phe 165 170 175 Cys Asp Ile Pro Pro Leu Leu Ala Leu Ala Cys Ser Asp Pro Trp Ile 180 185 190 Thr Gln Ile Leu Val Val Gly Cys Gly Gly Phe Thr Leu Val Thr Ser 195 200 205 Ile Val Val Ile Leu Val Ser Tyr Met Ser Val Leu Met Thr Ile Leu 210 215 220 Gly Ile Pro Ser Ala Ser Ser Lys Gln Lys Ala Phe Ser Thr Cys Ala 225 230 235 240 Ser His Met Thr Ala Val Gly Leu Tyr Tyr Gly Thr Thr Met Tyr Thr 245 250 255 Tyr Leu Gln Pro Ser Gln Arg Gly Ser Gln Ala Gly Asn Gln Met Val 260 265 270 Ser Val Phe Tyr Thr Met Val Ile Pro Met Leu Asn Pro Leu Ile Tyr 275 280 285 Ser Leu Arg Asn Gln Glu Val Lys Ala Ala Leu Trp Lys Ile Leu Lys 290 295 300

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Gln Ser Pro

305 <210> 3799 <211> 783 <212> DNA <213> Felis catus <400> 3799 atgcaccaag gaaaccaaag tatctccaaa ttcttcctcc tgggactcac tgtggggtct 60 gaacagcaga agctcatctt tatgctgttt ctgtgcatgt atctggtcac catggtagga 120 aacttactta tcatcctggc tattatcaat gatgctcacc ttcatagccc catgtacttc 180 ttccttgcca atctatcttt caatgacatc tgcttcacaa ccaccacaat ccccaaaatg 240 ttggcagaca tcccaagcca aagcccaacc atctcctttg caggatgcct cacacaaatg 300 tactttttta tgttgctggt ggacctggac aatttccttt tggcagccat ggcatatgac 360 cggtacgttg ccatctgtca cccattacac tatgctgcat tactgaaccc caagcgttgt 420 gccctgttgg tagtgactcc atgggtcatc tccaatcttg tctcaatact gcatctcagt 480 ctgctgagtc tcttgactat ctgtgatcag agaaaaatcc cacacttttt ctgtgacctg 540 gaacccattt taaggtttgc ttgctcagac actcaaatca atgacttgac aatcctagtt 600 gttgggggag cagttatctt tatccccttc accttcatta ttgtctccta tgccattatt 660 tgttgcactg tacttggggt tacttcagcc aaagggaagt ggagaacatt ctccacttgt 720 ggctcccatc tctcagctgt ggccctcttc tatggatcca ttgttggggt atactttctc 780 ccc 783 <210> 3800 <211> 261 <212> PRT <213> Felis catus <400> 3800

Met His Gln Gly Asn Gln Ser Ile Ser Lys Phe Phe Leu Leu Gly Leu 1 5 10 15

Thr Val Gly Ser Glu Gln Gln Lys Leu Ile Phe Met Leu Phe Leu Cys 20 25 30

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Met Tyr Leu 35 Val Thr Met Val Gly Asn Leu Leu Ile Ile Leu Ala Ile 40 45 Ile Asn Asp Ala His Leu His Ser Pro Met Tyr Phe Phe Leu Ala Asn 50 55 60 Leu Ser Phe Asn Asp Ile Cys Phe Thr Thr Thr Thr Ile Pro Lys Met 65 70 75 80 Leu Ala Asp Ile Pro Ser Gln Ser Pro Thr Ile Ser Phe Ala Gly Cys 85 90 95 Leu Thr Gln Met Tyr Phe Phe Met Leu Leu Val Asp Leu Asp Asn Phe 100 105 110 Leu Leu Ala Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys His Pro 115 120 125 Leu His Tyr Ala Ala Leu Leu Asn Pro Lys Arg Cys Ala Leu Leu Val 130 135 140 Val Thr Pro Trp Val Ile Ser Asn Leu Val Ser Ile Leu His Leu Ser 145 150 155 160 Leu Leu Ser Leu Leu Thr Ile Cys Asp Gln Arg Lys Ile Pro His Phe 165 170 175 Phe Cys Asp Leu Glu Pro Ile Leu Arg Phe Ala Cys Ser Asp Thr Gln 180 185 190 Ile Asn Asp Leu Thr Ile Leu Val Val Gly Gly Ala Val Ile Phe Ile 195 200 205 Pro Phe Thr Phe Ile Ile Val Ser Tyr Ala Ile Ile Cys Cys Thr Val 210 215 220 Leu Gly Val Thr Ser Ala Lys Gly Lys Trp Arg Thr Phe Ser Thr Cys 225 230 235 240

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Gly Ser His Leu Ser Ala Val Ala Leu Phe Tyr Gly Ser Ile Val Gly 245 250 255

Val Tyr Phe Leu Pro 260 <210> 3801 <211> 800 <212> DNA <213> Felis catus <400> 3801

ggaatggact tatcatcttt cttatctaca ttgaccccca cctgcacact ccaatgtact 60 tcttccttac taatctgtct ttcttagacc tttgctatgg aaccaattcc atgccccagg 120 ccttggtgca ctgtttctct acccatccct acctctctta ccgacgatgt ttgacccaaa 180 tgagtgtctc cttggtcttg gccacagcag agtgcctcct attggctgtc atggcctatg 240 atcgtatgat tgccatcagc aatcccctgc gctattccat gatcatgaat ggcccagtgt 300 gtgtctggct ggtggctacc tcatgggggg catcacttgt gctcactgct atgctcatca 360 tatccctgcc acttcacttc tgtggagcta atgtcatcaa ccattttgtc tgtgagattc 420 tttccctcct tgagctggcc tgttctgata ccagcctcaa tgagcttatg atcctcacca 480 caggtatctt caccctgctc ctaccctttg gatttgttct tctctcctat atccgaattg 540 ccactattgt cctaaggatt cgctcagtcc ggggtaggct caaggccttt tccacctgtg 600 gttctcattt gactgtggtg ataatcttct atggggcagc catctccatg tatatgaaac 660 ctcagtccaa gtcatcccct gaccagaaca agtttatttc agtgctttat ggggctctga 720 cacccatgct gaacccccta atatatagct tgaggaacaa ggatgttaaa ggggcaatga 780 ggaaaattat ggcaaaaagg 800

<210> 3802 <211> 266 <212> PRT <213> Felis catus <400> 3802

Asn Gly Leu Ile Ile Phe Leu Ile Tyr Ile Asp Pro His Leu His Thr 1 5 10 15

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Pro Met Tyr Phe Phe Leu 20 Thr Asn Leu Ser Phe Leu Asp Leu Cys Tyr 25 30 Gly Thr Asn Ser Met Pro Gln Ala Leu Val His Cys Phe Ser Thr His 35 40 45 Pro Tyr Leu Ser Tyr Arg Arg Cys Leu Thr Gln Met Ser Val Ser Leu 50 55 60 Val Leu Ala Thr Ala Glu Cys Leu Leu Leu Ala Val Met Ala Tyr Asp 65 70 75 80 Arg Met Ile Ala Ile Ser Asn Pro Leu Arg Tyr Ser Met Ile Met Asn 85 90 95 Gly Pro Val Cys Val Trp Leu Val Ala Thr Ser Trp Gly Ala Ser Leu 100 105 110 Val Leu Thr Ala Met Leu Ile Ile Ser Leu Pro Leu His Phe Cys Gly 115 120 125 Ala Asn Val Ile Asn His Phe Val Cys Glu Ile Leu Ser Leu Leu Glu 130 135 140 Leu Ala Cys Ser Asp Thr Ser Leu Asn Glu Leu Met Ile Leu Thr Thr 145 150 155 160 Gly Ile Phe Thr Leu Leu Leu Pro Phe Gly Phe Val Leu Leu Ser Tyr 165 170 175 Ile Arg Ile Ala Thr Ile Val Leu Arg Ile Arg Ser Val Arg Gly Arg 180 185 190 Leu Lys Ala Phe Ser Thr Cys Gly Ser His Leu Thr Val Val Ile Ile 195 200 205 Phe Tyr Gly Ala Ala Ile Ser Met Tyr Met Lys Pro Gln Ser Lys Ser 210 215 220

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Ser Pro Asp Gln Asn Lys Phe Ile Ser Val Leu Tyr Gly Ala Leu Thr 225 230 235 240 Pro Met Leu Asn Pro Leu Ile Tyr Ser Leu Arg Asn Lys Asp Val Lys 245 250 255 Gly Ala Met Arg Lys Ile Met Ala Lys Arg 260 265

<210> 3803 <211> 677 <212> DNA <213> Felis catus <400> 3803

tcaatggttt aaaagacgac cccaccattt tttatactag ctgttatggt cagatgacaa 60 tcactatttt tctggggatg acagagtgtc tcctccttgc tatcatggtt tatgatagat 120 ttattgcaat atctaatcct ctgtgttaca ccatcattat gaacaaccag gtctgcatac 180 agttggccat ggtgacttgg gccactgcct tccttttagc aataatactg atcattgcaa 240 ttcctgccca tttttgtgga tgcaatgtca tcaatcaatt tacctgtgag gtccaggccc 300 tattgaagct cactggctca aacaccccag tcagacttat tctgggtctg gtcataggca 360 tattcacact gcccctacct tttatcttca ttctcatctc ctatactcgc attgtggttg 420 tcatgctaag gatccactct gcagagggca ggctcaaagt tttttccacc tataggtccc 480 acctgactgt ggtcaccata ttttatggaa cagccatcta catgtacctg aaacctcaat 540 taagggagtc ccaggcccag ggtaaagtca tctctgcatt ttatggtgtt gtaacttcta 600 tgctgaaccc cctcatttac accttgagaa acaaagatgt gaaagatgtc ctaagaaaaa 660 ttatttgaaa gaaagaa 677

<210> 3804 <211> 221 <212> PRT <213> Felis catus <400> 3804

Asn Gly Leu Lys Asp Asp Pro Thr Ile Phe Tyr Thr Ser Cys Tyr Gly

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0 6926 9_02 25_S L.TX T 1 5 10 15 Gln Met Thr Ile Thr Ile Phe Leu Gly Met Thr Glu Cys Leu Leu Leu 20 25 30 Ala Ile Met Val Tyr Asp Arg Phe Ile Ala Ile Ser Asn Pro Leu Cys 35 40 45 Tyr Thr Ile Ile Met Asn Asn Gln Val Cys Ile Gln Leu Ala Met Val 50 55 60 Thr Trp Ala Thr Ala Phe Leu Leu Ala Ile Ile Leu Ile Ile Ala Ile 65 70 75 80 Pro Ala His Phe Cys Gly Cys Asn Val Ile Asn Gln Phe Thr Cys Glu 85 90 95 Val Gln Ala Leu Leu Lys Leu Thr Gly Ser Asn Thr Pro Val Arg Leu 100 105 110 Ile Leu Gly Leu Val Ile Gly Ile Phe Thr Leu Pro Leu Pro Phe Ile 115 120 125 Phe Ile Leu Ile Ser Tyr Thr Arg Ile Val Val Val Met Leu Arg Ile 130 135 140 His Ser Ala Glu Gly Arg Leu Lys Val Phe Ser Thr Tyr Arg Ser His 145 150 155 160 Leu Thr Val Val Thr Ile Phe Tyr Gly Thr Ala Ile Tyr Met Tyr Leu 165 170 175 Lys Pro Gln Leu Arg Glu Ser Gln Ala Gln Gly Lys Val Ile Ser Ala 180 185 190 Phe Tyr Gly Val Val Thr Ser Met Leu Asn Pro Leu Ile Tyr Thr Leu

195 200 205

Arg Asn Lys Asp Val Lys Asp Val Leu Arg Lys Ile Ile Page 4255

069269_0225_SL.TXT

210 215 220 <210> 3805 <211> 645 <212> DNA <213> Felis catus <400> 3805

tttttcctca gtaatttatc cttccttgat atctgttact ccaccagctg ggaaccatat 60 gtcttggccc aatgcttcag ggacttcccc attattttct ataccagctg ttatgcccag 120 atgaccacat ccctctttcc agggatgaca gaatgtctct tccatgctgt catggtttat 180 gacaggtttg ttgcaatctc caatcccctg cattacacca ccattatgaa taatgaagtt 240 tgcgtacagt tggccttggg aacctgggca agtgcattct tagtagcagt cttaccattc 300 attgcaattc ctgcttgtta ttatggacag aatgccatca gccattttac ctgtgagatc 360 caggccccgc tgaagctcat ctgctcagac actcctgtca gtctgattct gggtctggtt 420 atcagtgtgt tcatattgac cttgcctttc actatcatcc ttatttccta cttccacatt 480 gtggttatcg tgctgaggat ccattctgta gaggccagcc tcaaatcttt cttcatctgt 540 ggaccttatc taactgtggt caacatattt aatggtagag ccatctacat gtacctgaaa 600 cctcaaagaa atctcaggaa gaggacaaat tcgtctcaat atttt 645

<210> 3806 <211> 215 <212> PRT <213> Felis catus <400> 3806

Phe 1 Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile Cys Tyr Ser Thr Ser 5 10 15 Trp Glu Pro Tyr Val Leu Ala Gln Cys Phe Arg Asp Phe Pro Ile Ile 20 25 30 Phe Tyr Thr Ser Cys Tyr Ala Gln Met Thr Thr Ser Leu Phe Pro Gly 35 40 45 Met Thr Glu Cys Leu Phe His Ala Val Met Val Tyr Asp Arg Phe Val

50 55 60

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Ala Ile Ser Asn 65 Pro Leu His Tyr Thr Thr Ile Met Asn Asn Glu Val 70 75 80 Cys Val Gln Leu Ala Leu Gly Thr Trp Ala Ser Ala Phe Leu Val Ala 85 90 95 Val Leu Pro Phe Ile Ala Ile Pro Ala Cys Tyr Tyr Gly Gln Asn Ala 100 105 110 Ile Ser His Phe Thr Cys Glu Ile Gln Ala Pro Leu Lys Leu Ile Cys 115 120 125 Ser Asp Thr Pro Val Ser Leu Ile Leu Gly Leu Val Ile Ser Val Phe 130 135 140 Ile Leu Thr Leu Pro Phe Thr Ile Ile Leu Ile Ser Tyr Phe His Ile 145 150 155 160 Val Val Ile Val Leu Arg Ile His Ser Val Glu Ala Ser Leu Lys Ser 165 170 175 Phe Phe Ile Cys Gly Pro Tyr Leu Thr Val Val Asn Ile Phe Asn Gly 180 185 190 Arg Ala Ile Tyr Met Tyr Leu Lys Pro Gln Arg Asn Leu Arg Lys Arg 195 200 205 Thr Asn Ser Ser Gln Tyr Phe

210 215 <210> 3807 <211> 963 <212> DNA <213> Felis catus <400> 3807 tcaccttgca ttgggttcgt gcttcatctg gttatagctc ttcagaagtc tcctgagagc acccttaact tccttgttcc tcaggctata gatcataggg tagagcatcg gagttacatt

120

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069269_0225_SL.TXT ggtgtagatt aaggacacaa ctttgtcctg ttctggggtg tagcatgact tggggcgaat gtagatgaat attgcacagc catagtgcag aacagagacc agcaggtgcc cagcacaggt ggagaaggct ttgctccttc cttcagctga gtggattctg aggatggcag caataatgaa tgcataggag agcagaatca gcaagaaggg aatcaacagg atgagcatgc agacgaagaa gactgcaacc tcattggctc ttgtgtctga gcaggccaga aatagcacag cagggatgtc acagaaaaaa tgattgatct catgggactg acaaaagggc agtaggaata tcagtgtagt aagggcgagt gagagtgcaa agccgctgat gcatgccaga gtcagcatct gcagacagac ggtccgggtg atgatgattg tgtagcgcag ggggttgcag atggccacaa aacgatcata ggccatcatg gccaggagga aacactctgc gccaccgagg gcgatgaaga ggtgcatttg caaggcacag cccaggaagg acatccgctg gctcctggac aggaaattgg ccagcatgtt agggacaatc accaatatat agcaaatttc aatggtggac agattgcgaa ggaagaaata catgggggtc tggaggcagg agtcaacgag ggtgatgagc acaatagttg tgtgccctgc tagggtgaca agatgcatga ttagaaagag tccaaaaaag aagatttgca gttcacccag gtccccaaaa cccaagataa taaactcaga gcttaaggtg tggtttttct gaaactgggc cat <210> 3808 <211> 320 <212> PRT <213> Felis catus

180

240

300

360

420

480

540

600

660

720

780

840

900

960

963 <400> 3808

Met Ala Gln Phe Gln Lys Asn His Thr Leu Ser Ser Glu Phe Ile Ile 1 5 10 15 Leu Gly Phe Gly Asp Leu Gly Glu Leu Gln Ile Phe Phe Phe Gly Leu 20 25 30 Phe Leu Ile Met His Leu Val Thr Leu Ala Gly His Thr Thr Ile Val 35 40 45 Leu Ile Thr Leu Val Asp Ser Cys Leu Gln Thr Pro Met Tyr Phe Phe 50 55 60

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Leu 65 Arg Asn Leu Ser Thr Ile Glu Ile Cys Tyr Ile Leu Val Ile Val 70 75 80 Pro Asn Met Leu Ala Asn Phe Leu Ser Arg Ser Gln Arg Met Ser Phe 85 90 95 Leu Gly Cys Ala Leu Gln Met His Leu Phe Ile Ala Leu Gly Gly Ala 100 105 110 Glu Cys Phe Leu Leu Ala Met Met Ala Tyr Asp Arg Phe Val Ala Ile 115 120 125 Cys Asn Pro Leu Arg Tyr Thr Ile Ile Ile Thr Arg Thr Val Cys Leu 130 135 140 Gln Met Leu Thr Leu Ala Cys Ile Ser Gly Phe Ala Leu Ser Leu Ala 145 150 155 160 Leu Thr Thr Leu Ile Phe Leu Leu Pro Phe Cys Gln Ser His Glu Ile 165 170 175 Asn His Phe Phe Cys Asp Ile Pro Ala Val Leu Phe Leu Ala Cys Ser 180 185 190 Asp Thr Arg Ala Asn Glu Val Ala Val Phe Phe Val Cys Met Leu Ile 195 200 205 Leu Leu Ile Pro Phe Leu Leu Ile Leu Leu Ser Tyr Ala Phe Ile Ile 210 215 220 Ala Ala Ile Leu Arg Ile His Ser Ala Glu Gly Arg Ser Lys Ala Phe 225 230 235 240 Ser Thr Cys Ala Gly His Leu Leu Val Ser Val Leu His Tyr Gly Cys 245 250 255 Ala Ile Phe Ile Tyr Ile Arg Pro Lys Ser Cys Tyr Thr Pro Glu Gln 260 265 270

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Asp Lys Val Val Ser Leu Ile Tyr Thr Asn Val Thr Pro Met Leu Tyr 275 280 285 Pro Met Ile Tyr Ser Leu Arg Asn Lys Glu Val Lys Gly Ala Leu Arg 290 295 300 Arg Leu Leu Lys Ser Tyr Asn Gln Met Lys His Glu Pro Asn Ala Arg 305 310 315 320

<210> 3809 <211> 310 <212> PRT <213> Mus musculus <400> 3809

Met 1 Ala Thr Glu Asn 5 Ala Ser Val Pro Glu Phe Ile Leu Ala Gly Leu 10 15 Thr Asp Gln Pro Gly Leu Arg Met Pro Leu Phe Phe Leu Phe Leu Gly 20 25 30 Phe Tyr Met Val Thr Met Val Gly Asn Leu Gly Leu Ile Thr Leu Ile 35 40 45 Gly Leu Asn Ser His Leu His Thr Pro Met Tyr Phe Phe Leu Phe Asn 50 55 60 Leu Ser Leu Ile Asp Phe Cys Tyr Ser Thr Val Ile Thr Pro Lys Met 65 70 75 80 Leu Val Ser Phe Val Ser Lys Lys Asn Ile Ile Ser Tyr Ser Gly Cys 85 90 95 Met Thr Gln Leu Phe Phe Phe Leu Phe Phe Val Val Ser Glu Ser Phe 100 105 110 Ile Leu Ser Ala Met Ala Tyr Asp Arg Tyr Val Ala Ile Cys Asn Pro 115 120 125 Leu Met Tyr Thr Val Thr Met Ser Pro Gln Val Cys Leu Leu Leu Leu

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130 135 140

Leu Gly Val Tyr 145 Val Met Gly Phe Ala Gly Ala Met Ala His Thr Ala 150 155 160 Phe Met Val Lys Leu Thr Phe Cys Ala Asp Lys Leu Val Asn His Tyr 165 170 175 Met Cys Asp Ile Leu Pro Leu Leu Glu Arg Ser Cys Thr Ser Thr Tyr 180 185 190 Val Asn Glu Leu Val Val Phe Ile Val Val Gly Ile Asp Ile Gly Val 195 200 205 Pro Thr Val Thr Ile Phe Ile Ser Tyr Ala Leu Ile Leu Ser Ser Ile 210 215 220 Leu Arg Ile Ser Ser Thr Glu Gly Arg Ser Lys Ala Phe Ser Thr Cys 225 230 235 240 Ser Ser His Ile Ile Ala Val Ser Leu Phe Phe Gly Ser Gly Ala Phe 245 250 255 Met Tyr Leu Lys Pro Ser Ser Leu Leu Pro Met Asn Gln Gly Lys Val 260 265 270 Ser Ser Leu Phe Tyr Thr Ile Val Val Pro Met Leu Asn Pro Leu Ile 275 280 285 Tyr Ser Leu Arg Asn Lys Asp Val Lys Val Ala Leu Arg Lys Thr Leu

290 295 300 Ser Arg Ser Ser Phe Ser 305 310

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