WO2009052081A3 - Antibodies that bind il-4 and/or il-13 and their uses - Google Patents
Antibodies that bind il-4 and/or il-13 and their uses Download PDFInfo
- Publication number
- WO2009052081A3 WO2009052081A3 PCT/US2008/079787 US2008079787W WO2009052081A3 WO 2009052081 A3 WO2009052081 A3 WO 2009052081A3 US 2008079787 W US2008079787 W US 2008079787W WO 2009052081 A3 WO2009052081 A3 WO 2009052081A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibodies
- bind
- fragments
- novel
- dermatitis
- Prior art date
Links
- 108090000978 Interleukin-4 Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 206010012434 Dermatitis allergic Diseases 0.000 abstract 1
- 201000009961 allergic asthma Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/247—IL-4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Priority Applications (61)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19214415.2A EP3686220A1 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses |
KR1020107008006A KR101681909B1 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind IL-4 and/or IL-13 and their uses |
DK08839958.9T DK2205640T3 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and / or il-13 and uses thereof |
US12/682,864 US8388965B2 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind IL-4 and/or IL-13 and their uses |
MX2010003290A MX2010003290A (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses. |
SI200831156T SI2205640T1 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses |
NZ584658A NZ584658A (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses |
MX2012002055A MX363638B (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses. |
KR1020167033258A KR101823859B1 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind IL-4 and/or IL-13 and their uses |
RS20140077A RS53175B (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses |
KR1020147024155A KR101682373B1 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind IL-4 and/or IL-13 and their uses |
KR1020197005667A KR20190022928A (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind IL-4 and/or IL-13 and their uses |
AU2008312655A AU2008312655B2 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind IL-4 and/or IL-13 and their uses |
RU2010119521/10A RU2488595C2 (en) | 2007-10-15 | 2008-10-14 | Antibodies binding il-4 and/or bl-13 and their application |
JP2010530058A JP5858616B2 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind to IL-4 and / or IL-13 and uses thereof |
UAA201005855A UA104130C2 (en) | 2007-10-15 | 2008-10-14 | Antibody that bind il-4 and/or il-13 and method for treating asthma in mammals using the antibody |
CA2702473A CA2702473C (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses |
BRPI0818677A BRPI0818677B8 (en) | 2007-10-15 | 2008-10-14 | antibodies that bind to IL-4 and/or IL-13, pharmaceutical compositions comprising said antibodies, and uses thereof |
MX2012002053A MX354150B (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses. |
ES08839958.9T ES2447915T3 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind IL-4 and / or IL-13 and their uses |
EP08839958.9A EP2205640B1 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses |
MX2012010171A MX363634B (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses. |
CN200880111668.6A CN101827863B (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind IL-4 and/or IL-13 and their uses |
KR1020187002319A KR101954596B1 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind IL-4 and/or IL-13 and their uses |
MX2012010172A MX363901B (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses. |
PL08839958T PL2205640T3 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses |
TNP2010000126A TN2010000126A1 (en) | 2007-10-15 | 2010-03-22 | Antibodies that bind il-4 and/or il-13 and their uses |
ZA2010/02069A ZA201002069B (en) | 2007-10-15 | 2010-03-24 | Antibodies that bind il-4 and/or il-13 and their uses |
IL205005A IL205005A (en) | 2007-10-15 | 2010-04-11 | Bispecific antibody or bispecific antibody fragment thereof that specifically binds to il-13 and il-4 |
MA32823A MA31838B1 (en) | 2007-10-15 | 2010-05-10 | ANTIBODIES THAT BIND IL-4 AND / OR IL-3 AND USES THEREOF |
US13/758,858 US20130209469A1 (en) | 2007-10-15 | 2013-02-04 | Antibodies that bind il-4 and/or il-13 and their uses |
US13/794,384 US20130251718A1 (en) | 2007-10-15 | 2013-03-11 | Antibodies that bind il-4 and/or il-13 and their uses |
US13/794,320 US20130236460A1 (en) | 2007-10-15 | 2013-03-11 | Antibodies that bind il-4 and/or il-13 and their uses |
US13/794,394 US20130259866A1 (en) | 2007-10-15 | 2013-03-11 | Antibodies that bind il-4 and/or il-13 and their uses |
US13/794,341 US20130236461A1 (en) | 2007-10-15 | 2013-03-11 | Antibodies that bind il-4 and/or il-13 and their uses |
US13/794,295 US9738728B2 (en) | 2007-10-15 | 2013-03-11 | Antibodies that bind IL-4 and/or IL-13 and their uses |
US13/794,310 US20130251717A1 (en) | 2007-10-15 | 2013-03-11 | Antibodies that bind il-4 and/or il-13 and their uses |
US13/794,370 US20130236463A1 (en) | 2007-10-15 | 2013-03-11 | Antibodies that bind il-4 and/or il-13 and their uses |
US13/794,354 US20130236462A1 (en) | 2007-10-15 | 2013-03-11 | Antibodies that bind il-4 and/or il-13 and their uses |
US13/831,856 US20130243776A1 (en) | 2007-10-15 | 2013-03-15 | Antibodies that bind il-4 and/or il-13 and their uses |
US13/831,862 US9732162B2 (en) | 2007-10-15 | 2013-03-15 | Antibodies that bind IL-4 and/or IL-13 and their uses |
US13/831,884 US20130243778A1 (en) | 2007-10-15 | 2013-03-15 | Antibodies that bind il-4 and/or il-13 and their uses |
US13/831,866 US20140023649A1 (en) | 2007-10-15 | 2013-03-15 | Antibodies that bind il-4 and/or il-13 and their uses |
AU2013202389A AU2013202389B9 (en) | 2007-10-15 | 2013-04-04 | Antibodies that Bind IL-4 and/or IL-13 and their uses |
AU2013203324A AU2013203324C1 (en) | 2007-10-15 | 2013-04-10 | Antibodies that bind IL-4 and/or IL-13 and their uses |
AU2013203339A AU2013203339B9 (en) | 2007-10-15 | 2013-04-10 | Antibodies that bind IL-4 and/or IL-13 and their uses |
AU2013203328A AU2013203328B9 (en) | 2007-10-15 | 2013-04-10 | Antibodies that bind IL-4 and/or IL-13 and their uses |
PH12013501032A PH12013501032B1 (en) | 2007-10-15 | 2013-05-21 | Antibodies that bind il-4 and\or il-13 and their uses |
PH12013501033A PH12013501033B1 (en) | 2007-10-15 | 2013-05-21 | Antibodies that bind il-4 and\or il-13 and their uses |
HRP20140150AT HRP20140150T1 (en) | 2007-10-15 | 2014-02-18 | Antibodies that bind il-4 and/or il-13 and their uses |
CR20150101A CR20150101A (en) | 2007-10-15 | 2015-02-26 | ANTIBODIES THAT JOIN IL-4 AND / OR IL-13 |
CR20150103A CR20150103A (en) | 2007-10-15 | 2015-02-26 | ANTIBODIES THAT JOIN IL-4 AND / OR IL-13 (DIVISIONAL 1) |
CR20150102A CR20150102A (en) | 2007-10-15 | 2015-02-26 | ANTIBODIES THAT JOIN IL-4 AND / OR IL-13 (DIVISIONAL 2) |
CR20150654A CR20150654A (en) | 2007-10-15 | 2015-12-10 | ANTIBODIES THAT JOIN IL-4 AND / OR IL-13 AND ITS USES |
IL249289A IL249289A0 (en) | 2007-10-15 | 2016-11-29 | A bispecific antibody or bispecific antibody fragment thereof that specifically binds to il-13 and il-4 |
AU2017201008A AU2017201008B2 (en) | 2007-10-15 | 2017-02-15 | Antibodies that bind IL-4 and/or IL-13 and their uses |
AU2017201007A AU2017201007B2 (en) | 2007-10-15 | 2017-02-15 | Antibodies that bind IL-4 and/or IL-13 and their uses |
US15/645,765 US10759871B2 (en) | 2007-10-15 | 2017-07-10 | Antibodies that bind IL-4 and/or IL-13 and their uses |
AU2019201718A AU2019201718B2 (en) | 2007-10-15 | 2019-03-13 | Antibodies that bind IL-4 and/or IL-13 and their uses |
US16/941,272 US11453727B2 (en) | 2007-10-15 | 2020-07-28 | Antibodies that bind IL-4 and/or IL-13 and their uses |
US17/818,927 US20230235088A1 (en) | 2007-10-15 | 2022-08-10 | Antibodies that bind il-4 and/or il-13 and their uses |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07291259.5 | 2007-10-15 | ||
EP07291259A EP2050764A1 (en) | 2007-10-15 | 2007-10-15 | Novel polyvalent bispecific antibody format and uses thereof |
US3712808P | 2008-03-17 | 2008-03-17 | |
US61/037,128 | 2008-03-17 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/682,864 A-371-Of-International US8388965B2 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind IL-4 and/or IL-13 and their uses |
US13/758,858 Continuation US20130209469A1 (en) | 2007-10-15 | 2013-02-04 | Antibodies that bind il-4 and/or il-13 and their uses |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2009052081A2 WO2009052081A2 (en) | 2009-04-23 |
WO2009052081A3 true WO2009052081A3 (en) | 2009-06-04 |
WO2009052081A4 WO2009052081A4 (en) | 2009-07-23 |
Family
ID=39313041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/079787 WO2009052081A2 (en) | 2007-10-15 | 2008-10-14 | Antibodies that bind il-4 and/or il-13 and their uses |
Country Status (43)
Families Citing this family (166)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
CN101842387B (en) | 2007-09-26 | 2014-05-07 | Ucb医药有限公司 | Dual specificity antibody fusions |
EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
EP2615115A3 (en) * | 2007-11-30 | 2014-01-08 | Glaxo Group Limited | Antigen-binding constructs |
US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
US20110144311A1 (en) * | 2008-08-14 | 2011-06-16 | Rebecca Chmielowski | Methods for purifying antibodies using protein a affinity chromatography |
WO2010035012A1 (en) | 2008-09-26 | 2010-04-01 | Ucb Pharma S.A. | Biological products |
WO2010112193A1 (en) | 2009-04-02 | 2010-10-07 | Roche Glycart Ag | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
PT2417156E (en) | 2009-04-07 | 2015-04-29 | Roche Glycart Ag | Trivalent, bispecific antibodies |
US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
ES2667258T3 (en) * | 2009-09-10 | 2018-05-10 | Ucb Biopharma Sprl | Multivalent antibodies |
SG179196A1 (en) | 2009-09-16 | 2012-04-27 | Genentech Inc | Coiled coil and/or tether containing protein complexes and uses thereof |
GB201000467D0 (en) * | 2010-01-12 | 2010-02-24 | Ucb Pharma Sa | Antibodies |
TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
FR2958936A1 (en) | 2010-04-14 | 2011-10-21 | Sanofi Aventis | ROBO1-FC FUSION PROTEIN AND ITS USE IN THE TREATMENT OF TUMORS |
WO2012009544A2 (en) * | 2010-07-14 | 2012-01-19 | Amgen Inc. | Domain insertion immunoglobulin |
NZ707327A (en) * | 2010-08-02 | 2017-01-27 | Regeneron Pharma | Mice that make binding proteins comprising vl domains |
AR082461A1 (en) | 2010-08-03 | 2012-12-12 | Abbott Lab | IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME |
JP5758004B2 (en) | 2010-08-24 | 2015-08-05 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Bispecific antibodies comprising Fv fragments stabilized by disulfides |
MX340556B (en) | 2010-08-24 | 2016-07-14 | Roche Glycart Ag | Activatable bispecific antibodies. |
WO2012085111A1 (en) | 2010-12-23 | 2012-06-28 | F. Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
CN103502271B (en) | 2011-02-28 | 2016-10-26 | 霍夫曼-拉罗奇有限公司 | Antigen-binding proteins |
CN102675460B (en) * | 2011-02-28 | 2015-08-19 | 珠海市丽珠单抗生物技术有限公司 | The humanized antibody of Tumor necrosis factorα |
CA2824824A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Monovalent antigen binding proteins |
AR085911A1 (en) * | 2011-03-16 | 2013-11-06 | Sanofi Sa | SAFE THERAPEUTIC DOSE OF A SIMILAR PROTEIN TO AN ANTIBODY WITH VUAL REGION |
TWI803876B (en) * | 2011-03-28 | 2023-06-01 | 法商賽諾菲公司 | Dual variable region antibody-like binding proteins having cross-over binding region orientation |
RU2019122155A (en) * | 2011-03-28 | 2020-03-16 | Санофи | ANTIBODY-LIKE BINDING PROTEINS WITH DOUBLE VARIABLE AREAS, ORIENTING THE BINDING AREAS CROSS CROSS |
EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
CN107903325B (en) | 2011-05-16 | 2021-10-29 | 埃泰美德(香港)有限公司 | Multispecific FAB fusion proteins and methods of use thereof |
UY34105A (en) | 2011-06-03 | 2012-07-31 | Lg Life Sciences Ltd | STABLE LIQUID FORMULATION OF ETANERCEPT |
PT3572517T (en) | 2011-08-05 | 2021-06-23 | Regeneron Pharma | Humanized universal light chain mice |
UY34317A (en) | 2011-09-12 | 2013-02-28 | Genzyme Corp | T cell antireceptor antibody (alpha) / ß |
MX354902B (en) | 2011-11-23 | 2018-03-23 | Bioven 3 Ltd | RECOMBINANT PROTEINS and THEIR THERAPEUTIC USES. |
WO2013103783A1 (en) * | 2012-01-04 | 2013-07-11 | Sanofi Us | Murine il-13 antibodies |
MX2014009565A (en) | 2012-02-10 | 2014-11-10 | Genentech Inc | Single-chain antibodies and other heteromultimers. |
SG11201405830VA (en) * | 2012-03-27 | 2014-10-30 | Genentech Inc | Methods of prognosing, diagnosing and treating idiopathic pulmonary fibrosis |
WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
WO2014001325A1 (en) | 2012-06-27 | 2014-01-03 | F. Hoffmann-La Roche Ag | Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof |
BR112014032193A2 (en) | 2012-06-27 | 2017-06-27 | Hoffmann La Roche | bispecific antibody production and combination determination methods, bispecific antibody, formulation and use of bispecific antibody |
PT3470432T (en) | 2012-08-21 | 2021-12-14 | Regeneron Pharma | Methods for treating or preventing asthma by administering an il-4r antagonist |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
MX366103B (en) | 2012-09-12 | 2019-06-27 | Genzyme Corp | Fc containing polypeptides with altered glycosylation and reduced effector function. |
US9790268B2 (en) | 2012-09-12 | 2017-10-17 | Genzyme Corporation | Fc containing polypeptides with altered glycosylation and reduced effector function |
KR20210111353A (en) | 2012-11-01 | 2021-09-10 | 애브비 인코포레이티드 | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
SG10201802044RA (en) | 2012-11-01 | 2018-05-30 | Abbvie Inc | Stable dual variable domain immunoglobulin protein formulations |
KR102194748B1 (en) | 2012-11-20 | 2020-12-23 | 사노피 | Anti-ceacam5 antibodies and uses thereof |
EA201591219A1 (en) | 2012-12-27 | 2015-12-30 | Санофи | ANTIBODIES AGAINST LAMP1 AND CONJUGATES ANTIBODIES AND MEDICINES AND THEIR APPLICATION |
EP2983701A2 (en) | 2013-03-11 | 2016-02-17 | Genzyme Corporation | Site-specific antibody-drug conjugation through glycoengineering |
AU2013381687A1 (en) | 2013-03-12 | 2015-09-24 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
US20140302037A1 (en) * | 2013-03-15 | 2014-10-09 | Amgen Inc. | BISPECIFIC-Fc MOLECULES |
CN105530959B (en) * | 2013-03-15 | 2021-09-17 | 纪念斯隆-凯特琳癌症中心 | Multimerization techniques |
EP2970484B2 (en) * | 2013-03-15 | 2022-09-21 | Amgen Inc. | Heterodimeric bispecific antibodies |
MX2015013901A (en) * | 2013-04-05 | 2015-12-11 | Genentech Inc | Anti-il-4 antibodies and bispecific antibodies and uses thereof. |
TWI679019B (en) * | 2013-04-29 | 2019-12-11 | 法商賽諾菲公司 | Anti-il-4/anti-il-13 bispecific antibody formulations |
US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
JP6422956B2 (en) | 2013-10-11 | 2018-11-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Multispecific domain exchange common variable light chain antibody |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
TN2016000142A1 (en) | 2013-10-31 | 2017-10-06 | Sanofi Sa | Specific anti-cd38 antibodies for treating human cancers. |
WO2015070014A1 (en) * | 2013-11-08 | 2015-05-14 | Biogen Idec Ma Inc. | Procoagulant fusion compound |
US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
JP7325166B2 (en) | 2013-12-20 | 2023-08-14 | ジェネンテック, インコーポレイテッド | Bispecific antibody |
EP2893939A1 (en) | 2014-01-10 | 2015-07-15 | Netris Pharma | Anti-netrin-1 antibody |
US20150225479A1 (en) * | 2014-02-12 | 2015-08-13 | Sanofi | Anti-IL-4/Anti-IL-13 Bispecific Antibody/Polyglutamate Formulations |
KR102368450B1 (en) * | 2014-02-21 | 2022-02-28 | 사노피 바이오테크놀로지 | Methods for treating or preventing asthma by administering an il-4r antagonist |
MX2016010729A (en) * | 2014-02-21 | 2016-10-26 | Genentech Inc | Anti-il-13/il-17 bispecific antibodies and uses thereof. |
PL3129067T3 (en) | 2014-03-19 | 2023-05-08 | Genzyme Corporation | Site-specific glycoengineering of targeting moieties |
CN106255410B (en) | 2014-03-21 | 2020-01-10 | 瑞泽恩制药公司 | Non-human animals producing single domain binding proteins |
SG10201808083VA (en) | 2014-03-21 | 2018-10-30 | Regeneron Pharma | Vl antigen binding proteins exhibiting distinct binding characteristics |
TWI745962B (en) * | 2014-06-27 | 2021-11-11 | 法商賽諾菲公司 | Methods of determining whether a dose comprising a dual-v-region antibody-like protein or a fragment thereof administered to a human subject specifically binds to il-4 or il-13 within the human subject |
SI3169706T1 (en) | 2014-07-11 | 2020-04-30 | Genmab A/S | Antibodies binding axl |
EP3194446B1 (en) * | 2014-09-18 | 2022-10-26 | Cedars-Sinai Medical Center | Compositions and methods for treating fibrosis |
MX2017004664A (en) | 2014-10-09 | 2017-06-30 | Genzyme Corp | Glycoengineered antibody drug conjugates. |
EP3218412A1 (en) | 2014-11-14 | 2017-09-20 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist |
US10927185B2 (en) | 2014-11-21 | 2021-02-23 | Astellas Pharma Inc. | Bispecific antibody format |
JP6721590B2 (en) | 2014-12-03 | 2020-07-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Multispecific antibody |
WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
AU2016210068B2 (en) | 2015-01-23 | 2021-10-28 | Sanofi | Anti-CD3 antibodies, anti-CD123 antibodies and bispecific antibodies specifically binding to CD3 and/or CD123 |
MA41414A (en) | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | ICOS AGONIST BINDING PROTEINS |
EP3067062A1 (en) | 2015-03-13 | 2016-09-14 | Ipsen Pharma S.A.S. | Combination of tasquinimod or a pharmaceutically acceptable salt thereof and a pd1 and/or pdl1 inhibitor, for use as a medicament |
KR20170127011A (en) * | 2015-03-16 | 2017-11-20 | 제넨테크, 인크. | Methods for detecting and quantifying IL-13 and for diagnosing and treating TH2-related diseases |
CA2979702A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
TW201710286A (en) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | Binding proteins against VEGF, PDGF, and/or their receptors |
LT3319993T (en) | 2015-07-10 | 2020-05-11 | Genmab A/S | Axl-specific antibody-drug conjugates for cancer treatment |
WO2017074878A1 (en) | 2015-10-25 | 2017-05-04 | Sanofi | Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection |
TW201720459A (en) | 2015-11-02 | 2017-06-16 | 妮翠斯製藥公司 | Combination therapy of NTN1 neutralizing agent with drugs inhibiting epigenetic control |
WO2017117384A1 (en) | 2015-12-31 | 2017-07-06 | Development Center For Biotechnology | Anti-vegfr antibody and uses thereof |
CN108713026B (en) * | 2016-01-08 | 2023-01-06 | 美国全心医药生技股份有限公司 | Tetravalent anti-PSGL-1 antibodies and uses thereof |
US10870701B2 (en) | 2016-03-15 | 2020-12-22 | Generon (Shanghai) Corporation Ltd. | Multispecific fab fusion proteins and use thereof |
RS64771B1 (en) * | 2016-04-13 | 2023-11-30 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
TW201808336A (en) | 2016-05-11 | 2018-03-16 | 賽諾菲公司 | Treatment regimen using anti-MUC1 maytansinoid immunoconjugate antibody for the treatment of tumors |
KR20240017129A (en) | 2016-07-14 | 2024-02-06 | 젠맵 에이/에스 | Multispecific antibodies against cd40 and cd137 |
TWI790206B (en) | 2016-07-18 | 2023-01-21 | 法商賽諾菲公司 | Bispecific antibody-like binding proteins specifically binding to cd3 and cd123 |
CA3034768A1 (en) | 2016-08-26 | 2018-03-01 | Sanofi | Multispecific antibodies facilitating selective light chain pairing |
US11286295B2 (en) | 2016-10-20 | 2022-03-29 | Sanofi | Anti-CHIKV monoclonal antibodies directed against the E2 structural protein |
WO2018083126A1 (en) | 2016-11-01 | 2018-05-11 | Genmab B.V. | Polypeptide variants and uses thereof |
US20180206726A1 (en) | 2016-12-07 | 2018-07-26 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
JP7211952B2 (en) | 2017-01-05 | 2023-01-24 | ネトリス ファーマ | Combination treatment with netrin-1 inhibitors and immune checkpoint inhibitors |
JP7304288B2 (en) | 2017-02-17 | 2023-07-06 | サノフイ | Multispecific binding molecules with specificity for dystroglycan and laminin-2 |
US10626169B2 (en) | 2017-02-17 | 2020-04-21 | Sanofi | Multispecific binding molecules having specificity to dystroglycan and laminin-2 |
KR101961871B1 (en) * | 2017-02-20 | 2019-07-17 | 주식회사 와이바이오로직스 | Novel Multi-Specific Binding Proteins |
PT3443006T (en) | 2017-03-17 | 2023-10-26 | Sanofi Sa | Trispecific and/or trivalent binding proteins |
WO2018183932A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor |
MA49259A (en) | 2017-06-07 | 2020-04-15 | Genmab Bv | THERAPEUTIC ANTIBODIES BASED ON MUTATED IGG HEXAMERS |
JP2020525470A (en) * | 2017-07-03 | 2020-08-27 | ディヴェロップメント センター フォー バイオテクノロジー | Anti-VEGFR antibody and use thereof |
US11053309B2 (en) | 2017-08-04 | 2021-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for treating active eosinophilic esophagitis |
WO2019051204A1 (en) | 2017-09-08 | 2019-03-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Synergistic combination of il4 receptor targeted agents, interferon gamma, and interferon alpha for use in treating ovarian cancer |
US11186649B2 (en) | 2017-10-10 | 2021-11-30 | Sanofi | Anti-CD38 antibodies and methods of use |
CN109705217B (en) * | 2017-10-25 | 2020-09-11 | 北京智仁美博生物科技有限公司 | anti-IL-13 antibodies and uses thereof |
CN111526920A (en) | 2017-10-30 | 2020-08-11 | 赛诺菲生物技术公司 | Methods of treating or preventing asthma by administering IL-4R antagonists |
MX2020007444A (en) | 2018-01-12 | 2020-09-14 | Genzyme Corp | Methods for the quantitation of polypeptides. |
EP3743440A1 (en) | 2018-01-24 | 2020-12-02 | Genmab B.V. | Polypeptide variants and uses thereof |
AU2019212638A1 (en) | 2018-01-26 | 2020-09-17 | Genzyme Corporation | Fc variants with enhanced binding to FcRn and prolonged half-life |
US20210024632A1 (en) * | 2018-03-05 | 2021-01-28 | Etablissement Francais Du Sang | Recombinant single chain immunoglobulins |
JP2021517141A (en) * | 2018-03-09 | 2021-07-15 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | Combination therapy for cardiovascular disease |
MX2020011552A (en) | 2018-05-03 | 2020-11-24 | Genmab Bv | Antibody variant combinations and uses thereof. |
EP3810194A1 (en) | 2018-06-22 | 2021-04-28 | Genmab Holding B.V. | Anti-cd37 antibodies and anti-cd20 antibodies, compositions and methods of use thereof |
KR20210031932A (en) | 2018-07-13 | 2021-03-23 | 젠맵 에이/에스 | Variants of CD38 antibody and uses thereof |
EP3820890A1 (en) | 2018-07-13 | 2021-05-19 | Genmab A/S | Trogocytosis-mediated therapy using cd38 antibodies |
SG11202103100SA (en) | 2018-10-04 | 2021-04-29 | Genmab Holding B V | Pharmaceutical compositions comprising bispecific anti-cd37 antibodies |
AU2019357467A1 (en) | 2018-10-09 | 2021-05-27 | Sanofi | Trispecific anti-CD38, anti-CD28, and anti-CD3 binding proteins and methods of use for treating viral infection |
WO2020106754A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
WO2020132560A2 (en) | 2018-12-21 | 2020-06-25 | Aim Immunotech Inc. | Compositions and methods for cancer therapy |
CN111494625B (en) * | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | Pharmaceutical compositions for the treatment of IL-4 and/or IL-13 mediated signal transduction related disorders |
SG11202109003QA (en) | 2019-03-06 | 2021-09-29 | Regeneron Pharma | Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer |
CA3132587A1 (en) | 2019-03-21 | 2020-09-24 | Regeneron Pharmaceuticals, Inc. | Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy |
US11613576B2 (en) | 2019-04-09 | 2023-03-28 | Sanofi | Trispecific binding proteins, methods, and uses thereof |
WO2020242989A1 (en) | 2019-05-24 | 2020-12-03 | Sanofi | Methods for treating systemic sclerosis |
EP3753954A1 (en) | 2019-06-21 | 2020-12-23 | Université de Franche-Comté | Anti-cd123 antibodies, anti-cd123 chimeric antigen receptors and anti-cd123 chimeric antigen receptors t cells |
CN115175932A (en) | 2019-07-16 | 2022-10-11 | 赛诺菲 | Neutralizing anti-amyloid beta antibodies for the treatment of alzheimer's disease |
MX2022001038A (en) | 2019-07-25 | 2022-04-26 | Genzyme Corp | Methods of treating antibody-mediated disorders with fcrn antagonists. |
WO2021119482A1 (en) | 2019-12-13 | 2021-06-17 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
JP2023525423A (en) | 2020-01-15 | 2023-06-16 | イマティクス バイオテクノロジーズ ゲーエムベーハー | Antigen binding protein that specifically binds to PRAME |
EP4096625A1 (en) | 2020-01-31 | 2022-12-07 | Sanofi Biotechnology | Pulmonary delivery of antibodies |
CN115515643A (en) | 2020-02-28 | 2022-12-23 | 建新公司 | Modified binding polypeptides for optimized drug conjugation |
WO2021175924A1 (en) | 2020-03-03 | 2021-09-10 | Active Biotech Ab | Tasquinimod or a pharmaceutically acceptable salt thereof for use in combination therapy |
TW202146463A (en) | 2020-03-05 | 2021-12-16 | 法商賽諾菲公司 | Protease-processed molecules |
JP2023517753A (en) | 2020-03-18 | 2023-04-26 | ジェンマブ エー/エス | Antibody that binds to B7H4 |
CN115768484A (en) | 2020-04-24 | 2023-03-07 | 赛诺菲 | Antitumor combinations containing anti-CEACAM 5 antibody conjugates and irinotecan |
JP2023522393A (en) | 2020-04-24 | 2023-05-30 | サノフイ | Anti-tumor combination containing anti-CEACAM5 antibody conjugate and cetuximab |
JP2023522395A (en) | 2020-04-24 | 2023-05-30 | サノフイ | Anti-tumor combination containing anti-CEACAM5 antibody conjugate and forfox |
EP4138925A1 (en) | 2020-04-24 | 2023-03-01 | Sanofi | Antitumor combinations containing anti-ceacam5 antibody conjugates, trifluridine and tipiracil |
CN117327181A (en) * | 2020-06-22 | 2024-01-02 | 南京融捷康生物科技有限公司 | Single-domain antibody for resisting IL-4 Ralpha, application and medicine |
WO2021263075A1 (en) * | 2020-06-26 | 2021-12-30 | St. Jude Children's Research Hospital, Inc. | Methods of generating an activation inducible expression system in immune cells |
JP2023534726A (en) | 2020-07-23 | 2023-08-10 | ジェンマブ ビー.ブイ. | Combining anti-DR5 antibodies with immunomodulatory imide drugs for use in treating multiple myeloma |
BR112023003868A2 (en) | 2020-09-02 | 2023-04-04 | Genmab As | METHOD FOR PREVENTING OR REDUCING THE GROWTH OF A TUMOR, BINDING AGENT FOR USE IN PREVENTING OR REDUCING TUMOR GROWTH, IMMUNOGENIC COMPOSITION COMPRISING AT LEAST ONE VACCINE ANTIGEN FOR USE, USES OF A BINDING AGENT AND AN IMMUNOGENIC COMPOSITION, AND , KIT OF PARTS COMPRISING A BINDING AGENT |
IL301004A (en) | 2020-09-04 | 2023-04-01 | Merck Patent Gmbh | Anti-ceacam5 antibodies and conjugates and uses thereof |
JP2023551981A (en) * | 2020-12-07 | 2023-12-13 | ユーシービー バイオファルマ エスアールエル | Multispecific antibodies and antibody combinations |
WO2022184805A1 (en) | 2021-03-03 | 2022-09-09 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding sars-cov-2 antigenic peptides in complex with a major histocompatibility complex protein |
BR112023021089A2 (en) | 2021-05-07 | 2023-12-12 | Genmab As | PHARMACEUTICAL COMPOSITION, METHOD FOR TREATING A DISEASE, METHOD FOR TREATING CANCER IN AN INDIVIDUAL, USE OF THE PHARMACEUTICAL COMPOSITION, UNIT DOSAGE FORM, KIT OF PARTS, AND, METHOD FOR PREPARING A PHARMACEUTICAL COMPOSITION |
BR112023022584A2 (en) | 2021-05-27 | 2024-01-09 | Sanofi Sa | FC VARIANT WITH INTENSIFIED AFFINITY WITH FC RECEPTORS AND IMPROVED THERMAL STABILITY |
EP4362976A1 (en) | 2021-07-02 | 2024-05-08 | Merck Patent GmbH | Anti-protac antibodies and complexes |
CA3229324A1 (en) * | 2021-08-20 | 2023-02-23 | Beatrice DROUET | Mrna vaccines comprising il-4 and/or il-13 rna and uses thereof |
CA3237142A1 (en) | 2021-11-05 | 2023-05-11 | Sanofi | Antitumor combinations containing anti-ceacam5 antibody-drug conjugates and anti-vegfr-2 antibodies |
WO2023130010A1 (en) | 2021-12-30 | 2023-07-06 | Regeneron Pharmaceuticals, Inc. | Methods for attenuating atopic march by administering an il-4/il-13 antagonist |
US20240117030A1 (en) * | 2022-03-03 | 2024-04-11 | Pfizer Inc. | Multispecific antibodies and uses thereof |
WO2023170239A1 (en) | 2022-03-09 | 2023-09-14 | Merck Patent Gmbh | Methods and tools for conjugation to antibodies |
EP4245772A1 (en) | 2022-03-18 | 2023-09-20 | Netris Pharma | Anti-netrin-1 antibody to treat liver inflammation |
EP4249509A1 (en) | 2022-03-22 | 2023-09-27 | Netris Pharma | Anti-netrin-1 antibody against arthritis-associated pain |
WO2023227790A1 (en) | 2022-05-27 | 2023-11-30 | Sanofi | Natural killer (nk) cell engagers binding to nkp46 and bcma variants with fc-engineering |
US20240166750A1 (en) | 2022-10-25 | 2024-05-23 | Ablynx N.V. | GLYCOENGINEERED Fc VARIANT POLYPEPTIDES WITH ENHANCED EFFECTOR FUNCTION |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5705154A (en) * | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
US5928904A (en) * | 1993-09-07 | 1999-07-27 | Smithkline Beecham Corporation | DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
GB2403952A (en) * | 2003-07-15 | 2005-01-19 | Cambridge Antibody Tech | IL-13 binding molecules |
US20060063228A1 (en) * | 2004-06-09 | 2006-03-23 | Kasaian Marion T | Antibodies against human interleukin-13 and uses therefor |
US20070071675A1 (en) * | 2005-08-19 | 2007-03-29 | Chengbin Wu | Dual variable domain immunoglobulin and uses thereof |
WO2007080174A2 (en) * | 2006-01-11 | 2007-07-19 | Glaxo Group Limited | Chimeric and humanised anti-human il-13 antibodies |
WO2007085815A2 (en) * | 2006-01-24 | 2007-08-02 | Domantis Limited | Ligands that bind il-4 and/or il-13 |
WO2007107349A1 (en) * | 2006-03-22 | 2007-09-27 | Apogenix Gmbh | Antibody specific for human il-4 for the treament of cancer |
Family Cites Families (137)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4318980A (en) * | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
JPS6023084B2 (en) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | blood substitute |
JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
EP0028683A1 (en) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
US4444887A (en) | 1979-12-10 | 1984-04-24 | Sloan-Kettering Institute | Process for making human antibody producing B-lymphocytes |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
WO1982001188A1 (en) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | 4,5-deoxymaytansinoide compounds and process for preparing same |
US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4716111A (en) | 1982-08-11 | 1987-12-29 | Trustees Of Boston University | Process for producing human antibodies |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) * | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
JP2532858B2 (en) | 1985-04-01 | 1996-09-11 | セルテツク リミテツド | Transformed myeloma cell line |
US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
DE3675588D1 (en) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | HAEMOGLOBIN TIED TO A POLY (ALKENYLENE OXIDE). |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
EP0272253A4 (en) | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | Method for enhancing glycoprotein stability. |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4791192A (en) * | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
IL89489A0 (en) | 1988-03-09 | 1989-09-10 | Hybritech Inc | Chimeric antibodies directed against human carcinoembryonic antigen |
WO1989009622A1 (en) | 1988-04-15 | 1989-10-19 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
WO1989009825A1 (en) | 1988-04-16 | 1989-10-19 | Celltech Limited | Method for producing recombinant dna proteins |
AU631802B2 (en) | 1988-06-14 | 1992-12-10 | Cetus Oncology Corporation | Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US6048728A (en) | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
US5534617A (en) | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
WO1990005144A1 (en) | 1988-11-11 | 1990-05-17 | Medical Research Council | Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
ZA902949B (en) | 1989-05-05 | 1992-02-26 | Res Dev Foundation | A novel antibody delivery system for biological response modifiers |
CA2018228C (en) | 1989-06-05 | 1996-02-27 | Nancy L. Parenteau | Cell culture systems and media |
US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
FR2650598B1 (en) | 1989-08-03 | 1994-06-03 | Rhone Poulenc Sante | DERIVATIVES OF ALBUMIN WITH THERAPEUTIC FUNCTION |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US5314995A (en) | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
DE69127749T2 (en) | 1990-03-20 | 1998-04-16 | Univ Columbia | CHIMEAN ANTIBODIES WITH RECEPTOR-BINDING LIGANDS RATHER THAN YOUR CONSTANT REGION |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
DK0546073T3 (en) | 1990-08-29 | 1998-02-02 | Genpharm Int | Production and use of transgenic, non-human animals capable of forming heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
DK0574395T3 (en) | 1990-11-09 | 2002-10-07 | Stephen D Gillies | Cytokine immunoconjugates |
DE69233482T2 (en) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Method for reducing the immunogenicity of antibody variable domains |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
ES2241710T3 (en) | 1991-11-25 | 2005-11-01 | Enzon, Inc. | PROCEDURE TO PRODUCE MULTIVALENT PROTEINS FROM UNION TO ANTIGEN. |
WO1993011236A1 (en) | 1991-12-02 | 1993-06-10 | Medical Research Council | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
US5869619A (en) | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
FR2686899B1 (en) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
FR2686901A1 (en) | 1992-01-31 | 1993-08-06 | Rhone Poulenc Rorer Sa | NOVEL ANTITHROMBOTIC POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
EP0625200B1 (en) | 1992-02-06 | 2005-05-11 | Chiron Corporation | Biosynthetic binding protein for cancer marker |
CA2076465C (en) | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Cell binding agent conjugates of analogues and derivatives of cc-1065 |
AU4025193A (en) | 1992-04-08 | 1993-11-18 | Cetus Oncology Corporation | Humanized C-erbB-2 specific antibodies |
ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
AU658072B2 (en) | 1992-06-09 | 1995-03-30 | Hoppe Ag | Latch and lockset system |
CA2141602A1 (en) | 1992-08-26 | 1994-03-03 | Philip Leder | Use of the cytokine ip-10 as an anti-tumor agent |
US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
ES2162863T3 (en) | 1993-04-29 | 2002-01-16 | Unilever Nv | PRODUCTION OF ANTIBODIES OR FRAGMENTS (FUNCTIONALIZED) OF THE SAME DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF CAMELIDAE. |
UA40577C2 (en) * | 1993-08-02 | 2001-08-15 | Мерк Патент Гмбх | Bispecific antigen molecule for lysis of tumor cells, method for preparing of bispecific antigen molecule, monoclonal antibody (variants), pharmaceutical preparation, pharmaceutical kit for lysis of tumor cells (variants), method of lysis of tumor cells |
US20020193575A1 (en) | 1993-09-07 | 2002-12-19 | Smithkline Beecham P.L.C. | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
ZA946875B (en) * | 1993-09-07 | 1995-07-06 | Smithkline Beecham Corp | Recombinant il4 antibodies useful in treatment of il4 mediated disorders |
AU695726B2 (en) | 1993-09-07 | 1998-08-20 | Smithkline Beecham Corporation | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
WO1995009917A1 (en) * | 1993-10-07 | 1995-04-13 | The Regents Of The University Of California | Genetically engineered bispecific tetravalent antibodies |
US5597710A (en) | 1994-03-10 | 1997-01-28 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
US6165463A (en) | 1997-10-16 | 2000-12-26 | Inhale Therapeutic Systems, Inc. | Dispersible antibody compositions and methods for their preparation and use |
DE69637481T2 (en) | 1995-04-27 | 2009-04-09 | Amgen Fremont Inc. | Human antibodies to IL-8 derived from immunized Xenomae |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
WO1997014719A1 (en) * | 1995-10-16 | 1997-04-24 | Unilever N.V. | A bifunctional or bivalent antibody fragment analogue |
US6664227B1 (en) | 1996-03-01 | 2003-12-16 | Genetics Institute, Llc | Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains |
WO1997033899A1 (en) | 1996-03-14 | 1997-09-18 | Human Genome Sciences, Inc. | Apoptosis inducing molecule i |
WO1997034631A1 (en) | 1996-03-18 | 1997-09-25 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
EP0904278A4 (en) | 1996-03-22 | 1999-09-15 | Human Genome Sciences Inc | Apoptosis inducing molecule ii |
NZ331688A (en) | 1996-03-28 | 2000-02-28 | Univ Johns Hopkins | Soluble divalent and multivalent heterodimeric analogs of proteins |
US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
WO1998023289A1 (en) | 1996-11-27 | 1998-06-04 | The General Hospital Corporation | MODULATION OF IgG BINDING TO FcRn |
ATE387495T1 (en) | 1996-12-03 | 2008-03-15 | Amgen Fremont Inc | FULLY HUMANE ANTIBODIES THAT BIND EGFR |
GB9625899D0 (en) * | 1996-12-13 | 1997-01-29 | Glaxo Group Ltd | Substances and their uses |
US6277375B1 (en) * | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
TR199902553T2 (en) | 1997-04-14 | 2000-03-21 | Micromet Gesellschaft F�R Biomedizinische Forschung Mbh | New methods and uses for the production of antigen receptors against the human body. |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
ATE384732T1 (en) | 1997-11-03 | 2008-02-15 | Human Genome Sciences Inc | VEGI, AN INHIBITOR OF ANGIOGENESIS AND TUMOR GROWTH |
WO2000018435A1 (en) * | 1998-09-25 | 2000-04-06 | Horst Lindhofer | Time-staggered utilization of tumor cells in combination with intact antibodies for immunization |
TR200603997T1 (en) * | 1999-03-25 | 2010-01-21 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing them. |
CN101289511A (en) | 2000-04-11 | 2008-10-22 | 杰南技术公司 | Multivalent antibodies and uses therefore |
JP2003530838A (en) | 2000-04-12 | 2003-10-21 | ヒューマン ゲノム サイエンシズ インコーポレイテッド | Albumin fusion protein |
CA2409991A1 (en) * | 2000-05-24 | 2001-11-29 | Imclone Systems Incorporated | Bispecific immunoglobulin-like antigen binding proteins and method of production |
ATE545703T1 (en) * | 2000-07-25 | 2012-03-15 | Immunomedics Inc | MULTIVALENT TARGE-BINDING PROTEIN |
US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
RU2295537C2 (en) * | 2000-10-20 | 2007-03-20 | Тугаи Сейяку Кабусики Кайся | Modified antagonistic antibody |
US20040023338A1 (en) | 2001-10-26 | 2004-02-05 | Heavner George A. | IL-4 mutein proteins, antibodies, compositions, methods and uses |
CA2464695A1 (en) | 2001-10-26 | 2003-05-01 | Centocor, Inc. | Il-13 mutein proteins, antibodies, compositions, methods and uses |
CA2480777A1 (en) | 2002-05-01 | 2003-11-13 | Regeneron Pharmaceuticals, Inc. | Methods of using cytokine antagonists to treat hiv infection and aids |
US20070104710A1 (en) * | 2002-06-28 | 2007-05-10 | Domants Limited | Ligand that has binding specificity for IL-4 and/or IL-13 |
WO2004094613A2 (en) | 2003-04-22 | 2004-11-04 | Ibc Pharmaceuticals | Polyvalent protein complex |
CA2543982C (en) * | 2003-11-07 | 2013-01-08 | Immunex Corporation | Antibodies that bind interleukin-4 receptor |
PT2805728T (en) | 2003-12-23 | 2020-04-08 | Genentech Inc | Novel anti-il 13 antibodies and uses thereof |
US7652146B2 (en) | 2004-02-06 | 2010-01-26 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors |
NZ548612A (en) | 2004-02-09 | 2009-11-27 | Human Genome Sciences Inc | Albumin fusion proteins comprising tandem GLP-1 |
EP2026071B1 (en) | 2004-02-19 | 2013-07-31 | Yale University | Identification of cancer protein biomarkers using proteomic techniques |
CA2554596A1 (en) | 2004-02-27 | 2005-09-15 | Regeneron Pharmaceuticals, Inc. | Il-4/il-13 specific polypetides and therapeutic uses thereof |
GB0411186D0 (en) * | 2004-05-19 | 2004-06-23 | Celltech R&D Ltd | Biological products |
RU2006145905A (en) * | 2004-05-25 | 2008-06-27 | ЭТТЕНЬЮОН, ЭлЭлСи (US) | LIGANDS BINDING THE COMPLEX OF THE UROKINASE TYPE PLASMINOGEN ACTIVATOR TYPE (UPA) AND ITS RECEPTOR (UPAR), WHICH INHIBIT THE FOLLOWING UPAR INTERACTIONS: IEPILI IDENTIFICATION |
GB0414799D0 (en) * | 2004-07-01 | 2004-08-04 | Glaxo Group Ltd | Immunoglobulins |
US20060148009A1 (en) | 2004-10-12 | 2006-07-06 | Xencor, Inc. | Prediction and assessment of immunogenicity |
TWI306862B (en) * | 2005-01-03 | 2009-03-01 | Hoffmann La Roche | Antibodies against il-13 receptor alpha 1 and uses thereof |
US20090041783A1 (en) * | 2005-04-28 | 2009-02-12 | Mochida Pharmaceutical Co., Ltd. | Anti-platelet membrane glycoprotein vi monoclonal antibody |
GB0514319D0 (en) * | 2005-07-13 | 2006-06-14 | Secr Defence | Antibodies for anthrax |
PL1942939T5 (en) | 2005-09-30 | 2021-10-11 | Medimmune Limited | Interleukin-13 antibody composition |
WO2007045477A2 (en) * | 2005-10-21 | 2007-04-26 | Novartis Ag | Human antibodies against il-13 and therapeutic uses |
EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
AR085911A1 (en) * | 2011-03-16 | 2013-11-06 | Sanofi Sa | SAFE THERAPEUTIC DOSE OF A SIMILAR PROTEIN TO AN ANTIBODY WITH VUAL REGION |
TWI679019B (en) * | 2013-04-29 | 2019-12-11 | 法商賽諾菲公司 | Anti-il-4/anti-il-13 bispecific antibody formulations |
TWI745962B (en) * | 2014-06-27 | 2021-11-11 | 法商賽諾菲公司 | Methods of determining whether a dose comprising a dual-v-region antibody-like protein or a fragment thereof administered to a human subject specifically binds to il-4 or il-13 within the human subject |
-
2007
- 2007-10-15 EP EP07291259A patent/EP2050764A1/en not_active Ceased
-
2008
- 2008-10-13 PE PE2008001760A patent/PE20091382A1/en active IP Right Grant
- 2008-10-14 MX MX2010003290A patent/MX2010003290A/en active IP Right Grant
- 2008-10-14 RS RS20180381A patent/RS57060B1/en unknown
- 2008-10-14 DK DK12006789.7T patent/DK2574629T3/en active
- 2008-10-14 MY MYPI2010001251A patent/MY171214A/en unknown
- 2008-10-14 CL CL2008003037A patent/CL2008003037A1/en unknown
- 2008-10-14 DK DK08839958.9T patent/DK2205640T3/en active
- 2008-10-14 DK DK12006790.5T patent/DK2573121T3/en active
- 2008-10-14 SG SG10201602770UA patent/SG10201602770UA/en unknown
- 2008-10-14 ES ES12006797.0T patent/ES2664476T3/en active Active
- 2008-10-14 SI SI200831890T patent/SI2573121T1/en unknown
- 2008-10-14 CN CN202110668094.XA patent/CN113480647A/en active Pending
- 2008-10-14 ES ES12006789.7T patent/ES2660152T3/en active Active
- 2008-10-14 PL PL08839958T patent/PL2205640T3/en unknown
- 2008-10-14 PL PL12006790T patent/PL2573121T3/en unknown
- 2008-10-14 PT PT120067913T patent/PT2574630T/en unknown
- 2008-10-14 LT LTEP12006790.5T patent/LT2573121T/en unknown
- 2008-10-14 PT PT120067897T patent/PT2574629T/en unknown
- 2008-10-14 KR KR1020167033258A patent/KR101823859B1/en active IP Right Grant
- 2008-10-14 HU HUE12006790A patent/HUE037205T2/en unknown
- 2008-10-14 BR BRPI0818677A patent/BRPI0818677B8/en active IP Right Grant
- 2008-10-14 CA CA2702473A patent/CA2702473C/en active Active
- 2008-10-14 RS RS20180201A patent/RS56914B1/en unknown
- 2008-10-14 AR ARP080104471A patent/AR068861A1/en active IP Right Grant
- 2008-10-14 PL PL12006791T patent/PL2574630T3/en unknown
- 2008-10-14 KR KR1020147024155A patent/KR101682373B1/en active IP Right Grant
- 2008-10-14 TR TR2018/10005T patent/TR201810005T4/en unknown
- 2008-10-14 PL PL12006789T patent/PL2574629T3/en unknown
- 2008-10-14 RS RS20140077A patent/RS53175B/en unknown
- 2008-10-14 RS RS20171174A patent/RS56553B1/en unknown
- 2008-10-14 HU HUE12006789A patent/HUE036530T2/en unknown
- 2008-10-14 EP EP12006795A patent/EP2573117A1/en not_active Withdrawn
- 2008-10-14 EP EP12006794A patent/EP2573116A1/en not_active Ceased
- 2008-10-14 HU HUE12006791A patent/HUE038444T2/en unknown
- 2008-10-14 EP EP12006793A patent/EP2574626A1/en not_active Withdrawn
- 2008-10-14 MX MX2012002055A patent/MX363638B/en unknown
- 2008-10-14 EP EP12006789.7A patent/EP2574629B1/en active Active
- 2008-10-14 MX MX2012010171A patent/MX363634B/en unknown
- 2008-10-14 LT LTEP12006797.0T patent/LT2573119T/en unknown
- 2008-10-14 EP EP12006791.3A patent/EP2574630B1/en active Active
- 2008-10-14 SG SG10201913838RA patent/SG10201913838RA/en unknown
- 2008-10-14 HU HUE12006797A patent/HUE038556T2/en unknown
- 2008-10-14 EP EP19214415.2A patent/EP3686220A1/en active Pending
- 2008-10-14 CA CA3015470A patent/CA3015470C/en active Active
- 2008-10-14 ES ES12006791.3T patent/ES2679281T3/en active Active
- 2008-10-14 SI SI200831924T patent/SI2574629T1/en unknown
- 2008-10-14 PT PT120067905T patent/PT2573121T/en unknown
- 2008-10-14 RU RU2010119521/10A patent/RU2488595C2/en active
- 2008-10-14 JP JP2010530058A patent/JP5858616B2/en active Active
- 2008-10-14 UA UAA201005855A patent/UA104130C2/en unknown
- 2008-10-14 KR KR1020107008006A patent/KR101681909B1/en active IP Right Grant
- 2008-10-14 SI SI200831156T patent/SI2205640T1/en unknown
- 2008-10-14 KR KR1020197005667A patent/KR20190022928A/en not_active Application Discontinuation
- 2008-10-14 PT PT88399589T patent/PT2205640E/en unknown
- 2008-10-14 DK DK12006797.0T patent/DK2573119T3/en active
- 2008-10-14 MX MX2012002053A patent/MX354150B/en unknown
- 2008-10-14 EP EP12006796A patent/EP2573118A1/en not_active Withdrawn
- 2008-10-14 RS RS20180809A patent/RS57396B1/en unknown
- 2008-10-14 SI SI200831976T patent/SI2574630T1/en unknown
- 2008-10-14 NZ NZ709353A patent/NZ709353A/en unknown
- 2008-10-14 NO NO12006790A patent/NO2573121T3/no unknown
- 2008-10-14 DK DK12006791.3T patent/DK2574630T3/en active
- 2008-10-14 NZ NZ601342A patent/NZ601342A/en unknown
- 2008-10-14 LT LTEP12006789.7T patent/LT2574629T/en unknown
- 2008-10-14 AU AU2008312655A patent/AU2008312655B2/en active Active
- 2008-10-14 PT PT120067970T patent/PT2573119T/en unknown
- 2008-10-14 SI SI200831938T patent/SI2573119T1/en unknown
- 2008-10-14 LT LTEP12006791.3T patent/LT2574630T/en unknown
- 2008-10-14 MX MX2012010172A patent/MX363901B/en unknown
- 2008-10-14 PL PL12006797T patent/PL2573119T3/en unknown
- 2008-10-14 UA UAA201310544A patent/UA118949C2/en unknown
- 2008-10-14 WO PCT/US2008/079787 patent/WO2009052081A2/en active Application Filing
- 2008-10-14 EP EP12006790.5A patent/EP2573121B1/en active Active
- 2008-10-14 NZ NZ584658A patent/NZ584658A/en unknown
- 2008-10-14 EP EP08839958.9A patent/EP2205640B1/en active Active
- 2008-10-14 NO NO12006789A patent/NO2574629T3/no unknown
- 2008-10-14 SG SG10201913836SA patent/SG10201913836SA/en unknown
- 2008-10-14 CN CN201710131539.4A patent/CN106986938B/en active Active
- 2008-10-14 TR TR2018/02225T patent/TR201802225T4/en unknown
- 2008-10-14 RU RU2013120318/10A patent/RU2580049C2/en active
- 2008-10-14 EP EP12006792A patent/EP2573115A1/en not_active Ceased
- 2008-10-14 ES ES08839958.9T patent/ES2447915T3/en active Active
- 2008-10-14 EP EP12006797.0A patent/EP2573119B1/en active Active
- 2008-10-14 US US12/682,864 patent/US8388965B2/en active Active
- 2008-10-14 CA CA3071750A patent/CA3071750C/en active Active
- 2008-10-14 SG SG2012076568A patent/SG185303A1/en unknown
- 2008-10-14 CN CN200880111668.6A patent/CN101827863B/en active Active
- 2008-10-14 ES ES12006790.5T patent/ES2647872T3/en active Active
- 2008-10-14 KR KR1020187002319A patent/KR101954596B1/en active IP Right Grant
- 2008-10-15 UY UY31394A patent/UY31394A1/en not_active Application Discontinuation
- 2008-10-15 TW TW097139453A patent/TWI619508B/en active
- 2008-10-15 TW TW104112967A patent/TWI616206B/en active
- 2008-10-15 TW TW106136056A patent/TW201825117A/en unknown
- 2008-10-15 TW TW104112966A patent/TWI616205B/en active
- 2008-10-15 PA PA20088799001A patent/PA8799001A1/en unknown
-
2010
- 2010-03-22 TN TNP2010000126A patent/TN2010000126A1/en unknown
- 2010-03-23 NI NI2010000405A patent/NI201000405A/en unknown
- 2010-03-23 NI NI201000040A patent/NI201000040A/en unknown
- 2010-03-23 NI NI2010000401A patent/NI201000401A/en unknown
- 2010-03-23 NI NI2010000404A patent/NI201000404A/en unknown
- 2010-03-23 NI NI2010000402A patent/NI201000402A/en unknown
- 2010-03-23 NI NI2010000403A patent/NI201000403A/en unknown
- 2010-03-23 NI NI2010000406A patent/NI201000406A/en unknown
- 2010-03-24 GT GT201000067A patent/GT201000067A/en unknown
- 2010-03-24 ZA ZA2010/02069A patent/ZA201002069B/en unknown
- 2010-03-25 CR CR11337A patent/CR11337A/en unknown
- 2010-03-25 MX MX2012002056A patent/MX354666B/en unknown
- 2010-04-11 IL IL205005A patent/IL205005A/en active IP Right Grant
- 2010-04-14 DO DO2010000109A patent/DOP2010000109A/en unknown
- 2010-04-14 HN HN2010000710A patent/HN2010000710A/en unknown
- 2010-05-10 MA MA32823A patent/MA31838B1/en unknown
-
2012
- 2012-11-15 CL CL2012003196A patent/CL2012003196A1/en unknown
-
2013
- 2013-02-04 US US13/758,858 patent/US20130209469A1/en not_active Abandoned
- 2013-03-11 US US13/794,384 patent/US20130251718A1/en not_active Abandoned
- 2013-03-11 US US13/794,341 patent/US20130236461A1/en not_active Abandoned
- 2013-03-11 US US13/794,320 patent/US20130236460A1/en not_active Abandoned
- 2013-03-11 US US13/794,310 patent/US20130251717A1/en not_active Abandoned
- 2013-03-11 US US13/794,394 patent/US20130259866A1/en not_active Abandoned
- 2013-03-11 US US13/794,295 patent/US9738728B2/en active Active
- 2013-03-11 US US13/794,354 patent/US20130236462A1/en not_active Abandoned
- 2013-03-11 US US13/794,370 patent/US20130236463A1/en not_active Abandoned
- 2013-03-15 US US13/831,862 patent/US9732162B2/en active Active
- 2013-03-15 US US13/831,856 patent/US20130243776A1/en not_active Abandoned
- 2013-03-15 US US13/831,884 patent/US20130243778A1/en not_active Abandoned
- 2013-03-15 US US13/831,866 patent/US20140023649A1/en not_active Abandoned
- 2013-04-04 AU AU2013202389A patent/AU2013202389B9/en active Active
- 2013-04-10 AU AU2013203324A patent/AU2013203324C1/en active Active
- 2013-04-10 AU AU2013203339A patent/AU2013203339B9/en active Active
- 2013-04-10 AU AU2013203328A patent/AU2013203328B9/en active Active
- 2013-05-21 PH PH12013501033A patent/PH12013501033B1/en unknown
- 2013-05-21 PH PH12013501032A patent/PH12013501032B1/en unknown
- 2013-07-12 CL CL2013002040A patent/CL2013002040A1/en unknown
- 2013-07-12 CL CL2013002039A patent/CL2013002039A1/en unknown
- 2013-12-12 DO DO2013000301A patent/DOP2013000301A/en unknown
- 2013-12-12 DO DO2013000302A patent/DOP2013000302A/en unknown
-
2014
- 2014-02-18 HR HRP20140150AT patent/HRP20140150T1/en unknown
- 2014-02-20 CY CY20141100136T patent/CY1114987T1/en unknown
-
2015
- 2015-02-26 CR CR20150103A patent/CR20150103A/en unknown
- 2015-02-26 CR CR20150101A patent/CR20150101A/en unknown
- 2015-02-26 CR CR20150102A patent/CR20150102A/en unknown
- 2015-07-31 JP JP2015151693A patent/JP6280526B2/en active Active
- 2015-07-31 JP JP2015151694A patent/JP6126652B2/en active Active
- 2015-07-31 JP JP2015151695A patent/JP6126653B2/en active Active
- 2015-09-29 RU RU2015141418A patent/RU2721236C2/en active
- 2015-09-29 RU RU2015141428A patent/RU2705551C2/en active
- 2015-12-10 CR CR20150654A patent/CR20150654A/en unknown
-
2016
- 2016-11-29 IL IL249289A patent/IL249289A0/en unknown
-
2017
- 2017-07-10 US US15/645,765 patent/US10759871B2/en active Active
- 2017-11-16 HR HRP20171765TT patent/HRP20171765T1/en unknown
- 2017-11-22 CY CY20171101220T patent/CY1119875T1/en unknown
-
2018
- 2018-01-18 JP JP2018006055A patent/JP2018078907A/en active Pending
- 2018-02-21 HR HRP20180320TT patent/HRP20180320T1/en unknown
- 2018-02-22 CY CY20181100211T patent/CY1120033T1/en unknown
- 2018-03-27 HR HRP20180517TT patent/HRP20180517T1/en unknown
- 2018-03-30 CY CY20181100360T patent/CY1120108T1/en unknown
- 2018-07-10 HR HRP20181085TT patent/HRP20181085T1/en unknown
- 2018-07-17 CY CY181100741T patent/CY1120887T1/en unknown
- 2018-10-18 AR ARP180103043A patent/AR122834A2/en unknown
- 2018-10-18 AR ARP180103042A patent/AR122833A2/en unknown
-
2020
- 2020-07-28 US US16/941,272 patent/US11453727B2/en active Active
-
2022
- 2022-08-10 US US17/818,927 patent/US20230235088A1/en active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5928904A (en) * | 1993-09-07 | 1999-07-27 | Smithkline Beecham Corporation | DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
US5705154A (en) * | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
GB2403952A (en) * | 2003-07-15 | 2005-01-19 | Cambridge Antibody Tech | IL-13 binding molecules |
US20060063228A1 (en) * | 2004-06-09 | 2006-03-23 | Kasaian Marion T | Antibodies against human interleukin-13 and uses therefor |
US20070071675A1 (en) * | 2005-08-19 | 2007-03-29 | Chengbin Wu | Dual variable domain immunoglobulin and uses thereof |
WO2007080174A2 (en) * | 2006-01-11 | 2007-07-19 | Glaxo Group Limited | Chimeric and humanised anti-human il-13 antibodies |
WO2007085815A2 (en) * | 2006-01-24 | 2007-08-02 | Domantis Limited | Ligands that bind il-4 and/or il-13 |
WO2007107349A1 (en) * | 2006-03-22 | 2007-09-27 | Apogenix Gmbh | Antibody specific for human il-4 for the treament of cancer |
Non-Patent Citations (1)
Title |
---|
HART T K ET AL: "Preclinical efficacy and safety of pascolizumab (SB 240683): A humanized anti-interleukin-4 antibody with therapeutic potential in asthma", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 130, no. 1, 1 October 2002 (2002-10-01), pages 93 - 100, XP002434532, ISSN: 0009-9104 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2009052081A3 (en) | Antibodies that bind il-4 and/or il-13 and their uses | |
WO2008123999A3 (en) | Anti-ige antibodies | |
TW200736274A (en) | Immunoglobulins | |
WO2010032059A3 (en) | Antibodies directed to cd105 and uses thereof | |
WO2007045477A3 (en) | Human antibodies against il-13 and therapeutic uses | |
MY162511A (en) | Engineered anti-tslp antibody | |
WO2008097461A3 (en) | Hepcidin and hepcidin antibodies | |
WO2008099178A3 (en) | Binding members for ige molecules | |
DK2417158T4 (en) | DKK-1 ANTIBODIES | |
WO2010038155A3 (en) | Antibodies against il-25 | |
WO2011143557A3 (en) | Humanized ttc and methods of use thereof | |
WO2011080050A3 (en) | Ccl21 binding molecules | |
WO2010120566A3 (en) | METHODS FOR TREATING IgE-MEDIATED DISORDER | |
TNSN08175A1 (en) | Human antibodies against il-13 and therapeutic uses |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200880111668.6 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08839958 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 201011337 Country of ref document: CR Ref document number: CR2010-011337 Country of ref document: CR Ref document number: MX/A/2010/003290 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010/CHENP/2010 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 205005 Country of ref document: IL |
|
ENP | Entry into the national phase |
Ref document number: 20107008006 Country of ref document: KR Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2702473 Country of ref document: CA Ref document number: 2008312655 Country of ref document: AU Ref document number: 12682864 Country of ref document: US |
|
ENP | Entry into the national phase |
Ref document number: 1001074 Country of ref document: KE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010040607 Country of ref document: EG Ref document number: 2010530058 Country of ref document: JP Ref document number: 12010500818 Country of ref document: PH |
|
WWE | Wipo information: entry into national phase |
Ref document number: 584658 Country of ref document: NZ Ref document number: 10044108 Country of ref document: CO Ref document number: 13198470 Country of ref document: CO Ref document number: 13198466 Country of ref document: CO |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: DZP2010000231 Country of ref document: DZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008839958 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2008312655 Country of ref document: AU Date of ref document: 20081014 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: PI 2010001251 Country of ref document: MY |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010119521 Country of ref document: RU |
|
WWE | Wipo information: entry into national phase |
Ref document number: P-2014/0077 Country of ref document: RS |
|
WWE | Wipo information: entry into national phase |
Ref document number: CR2015-000101 Country of ref document: CR Ref document number: CR2015-000103 Country of ref document: CR Ref document number: CR2015-000102 Country of ref document: CR |
|
ENP | Entry into the national phase |
Ref document number: PI0818677 Country of ref document: BR Kind code of ref document: A2 Effective date: 20100415 |
|
WWE | Wipo information: entry into national phase |
Ref document number: CR2015-000654 Country of ref document: CR |
|
WWE | Wipo information: entry into national phase |
Ref document number: IDP00201602526 Country of ref document: ID Ref document number: IDP00201602525 Country of ref document: ID Ref document number: IDP00201602523 Country of ref document: ID Ref document number: IDP00201602521 Country of ref document: ID |
|
WWE | Wipo information: entry into national phase |
Ref document number: 249289 Country of ref document: IL |