UY34317A - Anticuerpo antireceptor de célula T (alfa)/ß - Google Patents
Anticuerpo antireceptor de célula T (alfa)/ßInfo
- Publication number
- UY34317A UY34317A UY0001034317A UY34317A UY34317A UY 34317 A UY34317 A UY 34317A UY 0001034317 A UY0001034317 A UY 0001034317A UY 34317 A UY34317 A UY 34317A UY 34317 A UY34317 A UY 34317A
- Authority
- UY
- Uruguay
- Prior art keywords
- alpha
- cell
- antireceptor antibody
- antireceptor
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
La presente invención describe anticuerpos monoclonales humanizados que incluyen los CDR del anticuerpo murino BMA031, que se une al complejo RCT aß·CD3 y se caracteriza por sus propiedades biológicas mejoradas
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161533510P | 2011-09-12 | 2011-09-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY34317A true UY34317A (es) | 2013-02-28 |
Family
ID=46851393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001034317A UY34317A (es) | 2011-09-12 | 2012-09-10 | Anticuerpo antireceptor de célula T (alfa)/ß |
Country Status (34)
Country | Link |
---|---|
US (3) | US10017573B2 (es) |
EP (1) | EP2755999B1 (es) |
JP (2) | JP6096196B2 (es) |
KR (1) | KR20140072092A (es) |
CN (2) | CN110272492A (es) |
AU (2) | AU2012307816C1 (es) |
BR (2) | BR112014005644A2 (es) |
CA (1) | CA2847949C (es) |
CL (2) | CL2014000574A1 (es) |
CO (1) | CO6930307A2 (es) |
CR (1) | CR20140127A (es) |
DK (1) | DK2755999T3 (es) |
DO (1) | DOP2014000052A (es) |
EC (1) | ECSP14013307A (es) |
ES (1) | ES2667893T3 (es) |
GT (1) | GT201400045A (es) |
HK (1) | HK1199268A1 (es) |
HU (1) | HUE037470T2 (es) |
IL (2) | IL231304B (es) |
LT (1) | LT2755999T (es) |
MA (1) | MA35711B1 (es) |
MX (1) | MX355735B (es) |
MY (1) | MY173924A (es) |
NI (1) | NI201400019A (es) |
PE (1) | PE20141548A1 (es) |
PL (1) | PL2755999T3 (es) |
PT (1) | PT2755999T (es) |
RU (2) | RU2630656C2 (es) |
SG (2) | SG11201400126PA (es) |
TN (1) | TN2014000107A1 (es) |
TW (1) | TWI593706B (es) |
UA (1) | UA115533C2 (es) |
UY (1) | UY34317A (es) |
WO (1) | WO2013037484A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
US9790268B2 (en) | 2012-09-12 | 2017-10-17 | Genzyme Corporation | Fc containing polypeptides with altered glycosylation and reduced effector function |
CN104797601B (zh) * | 2012-09-12 | 2019-08-30 | 建新公司 | 具有改变的糖基化和降低的效应物功能的包含fc的多肽 |
KR20220103204A (ko) | 2013-03-11 | 2022-07-21 | 젠자임 코포레이션 | 과글리코실화된 결합 폴리펩티드 |
CA2928756A1 (en) | 2013-10-30 | 2015-05-07 | Genzyme Corporation | Methods for enhancing immunosuppressive therapy by multiple administration of alpha beta tcr-binding polypeptide |
US10995148B2 (en) | 2014-03-19 | 2021-05-04 | Genzyme Corporation | Site-specific glycoengineering of targeting moieties |
EP3799887A1 (en) | 2014-10-09 | 2021-04-07 | Genzyme Corporation | Glycoengineered antibody drug conjugates |
WO2016059220A1 (en) | 2014-10-16 | 2016-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Tcr-activating agents for use in the treatment of t-all |
CN108026171A (zh) * | 2015-06-01 | 2018-05-11 | 基因医疗免疫疗法有限责任公司 | T细胞受体特异性抗体 |
CN110914308A (zh) | 2017-07-14 | 2020-03-24 | 伊玛提克斯生物技术有限公司 | 改进的双特异性多肽分子 |
RU2708558C1 (ru) * | 2018-12-13 | 2019-12-09 | Российская Федерация, от имени которой выступает ФОНД ПЕРСПЕКТИВНЫХ ИССЛЕДОВАНИЙ | Способ создания противоопухолевой иммунологической защиты к клеткам лимфомы EL-4 |
JP2022521850A (ja) * | 2019-04-03 | 2022-04-12 | ジェンザイム・コーポレーション | 断片化が低減した抗アルファベータtcr結合ポリペプチド |
WO2020232247A1 (en) | 2019-05-14 | 2020-11-19 | Provention Bio, Inc. | Methods and compositions for preventing type 1 diabetes |
CN113122503B (zh) * | 2019-12-30 | 2022-10-11 | 博雅缉因(北京)生物科技有限公司 | 一种靶向t细胞淋巴瘤细胞的通用型car-t及其制备方法和应用 |
CN113122504A (zh) * | 2019-12-30 | 2021-07-16 | 博雅辑因(北京)生物科技有限公司 | 一种纯化ucart细胞的方法与应用 |
EP4086341A1 (en) * | 2019-12-30 | 2022-11-09 | Edigene Biotechnology Inc. | Method for purifying ucart cell and use thereof |
CN113088495A (zh) * | 2020-01-09 | 2021-07-09 | 苏州方德门达新药开发有限公司 | 工程改造的t细胞、其制备及应用 |
WO2023227018A1 (zh) * | 2022-05-25 | 2023-11-30 | 羿尊生物医药(浙江)有限公司 | 靶向细胞膜受体蛋白的融合蛋白及其应用 |
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