UY34394A - Polipéptidos de anticuerpos que antagonizan cd40l - Google Patents

Polipéptidos de anticuerpos que antagonizan cd40l

Info

Publication number
UY34394A
UY34394A UY0001034394A UY34394A UY34394A UY 34394 A UY34394 A UY 34394A UY 0001034394 A UY0001034394 A UY 0001034394A UY 34394 A UY34394 A UY 34394A UY 34394 A UY34394 A UY 34394A
Authority
UY
Uruguay
Prior art keywords
polipeptides
antibody
cd40l
antagonizing
antagonizing cd40l
Prior art date
Application number
UY0001034394A
Other languages
English (en)
Inventor
Steven G Nadler
James K Tamura
Price Laura
Robert P Rehfuss
Suzanne J Suchard
Suri Anish
James William Bryson
Yamniuk Aaron
Grant Steven
Ignatovich Olga
Drew Philip
Original Assignee
Domantis Ltd
Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47046896&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY34394(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Domantis Ltd, Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware filed Critical Domantis Ltd
Publication of UY34394A publication Critical patent/UY34394A/es

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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

Polipéptidos de anticuerpos que se fijan específicamente al CD40L humano. Los polipéptidos de anticuerpos no activan plaquetas. Los polipéptidos de anticuerpos son útiles para el tratamiento de enfermedades que implican la activación de CD40L, tales como enfermedades relacionadas con el injerto y enfermedades utoinmunitarias. Los polipéptidos de anticuerpos pueden ser anticuerpos de dominio (dAb) que comprenden un solo dominio VH o VK. La vida media de los polipéptidos de anticuerpos se puede aumentar modificando los polipéptidos de anticuerpos para que sean reactivos específicos duales que también puedan fijarse a la albúmina de suero h umana (HSA) o a otro antígeno.
UY0001034394A 2011-10-13 2012-10-12 Polipéptidos de anticuerpos que antagonizan cd40l UY34394A (es)

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