KR20140069349A - Cd40l을 길항하는 항체 폴리펩티드 - Google Patents

Cd40l을 길항하는 항체 폴리펩티드 Download PDF

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KR20140069349A
KR20140069349A KR1020147012398A KR20147012398A KR20140069349A KR 20140069349 A KR20140069349 A KR 20140069349A KR 1020147012398 A KR1020147012398 A KR 1020147012398A KR 20147012398 A KR20147012398 A KR 20147012398A KR 20140069349 A KR20140069349 A KR 20140069349A
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KR101637915B1 (ko
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스티븐 지. 나들러
제임스 케이. 타무라
로라 프라이스
로버트 피. 레푸스
수잔 제이. 수카드
아니쉬 수리
제임스 윌리엄 브리슨
아론 얌니욱
스티븐 그랜트
올가 이그나토비히
필립 드류
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브리스톨-마이어스 스큅 컴퍼니
도만티스 리미티드
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Abstract

인간 CD40L에 특이적으로 결합하는 항체 폴리펩티드를 제공한다. 상기 항체 폴리펩티드는 혈소판을 활성화시키지 않는다. 항체 폴리펩티드는 이식편-관련 질환 및 자가면역 질환과 같은 CD40L 활성화가 관련된 질환의 치료에 유용하다. 항체 폴리펩티드는 단일 VH 또는 VK 도메인을 포함하는 도메인 항체 (dAb)일 수 있다. 항체 폴리펩티드의 반감기는 인간 혈청 알부민 (HSA) 또는 또 다른 항원에 또한 결합할 수 있는 이중 특이적 시약이 되도록 항체 폴리펩티드를 변형시킴으로써 증가시킬 수 있다.

Description

CD40L을 길항하는 항체 폴리펩티드 {ANTIBODY POLYPEPTIDES THAT ANTAGONIZE CD40L}
CD40L을 표적으로 하는 항체 및 그의 단편, 이들을 포함하는 조성물, 및 CD40L 활성이 관련된 질환의 치료를 위한 이들의 사용 방법을 제공한다.
서열 목록
본 출원은 EFS-Web을 통해 ASCII 포맷으로 제출되고 그 전문이 본원에 참조로 포함된 서열 목록을 함유한다. 2012년 10월 8일 생성된 상기 ASCII 카피는 20089600.txt로 명명되고 1,254,371 바이트 크기이다.
CD154, gp39, TNF-관련 활성화 단백질 (TRAP), 5c8 항원, 또는 T-BAM으로도 알려진 CD40 리간드 (CD40L)는 종양 괴사 인자 (TNF) 슈퍼패밀리 분자의 삼량체성 막횡단 단백질이다. CD40L은 주로 활성화된 T 세포뿐만 아니라 활성화된 백혈구, 호산구, 호염기구, 자연 킬러 세포, 비만 세포, 및 비-면역 세포, 예컨대 혈소판 및 활성화된 내피 세포 상에서 발현된다. 또한, CD40L은 막-결합형 CD40L의 마이크로솜 (microsomal) 자극-의존성 절단에 의해 생산되는 가용성 형태 (sCD40L)로도 존재한다. 순환계 내의 대부분의 sCD40L (>90%)은 혈소판에서 유래한 것이다.
CD40L은 CD40 (TNF 수용체 (TNFR) 패밀리에 속하는 타입 I 막횡단 당단백질)에 결합한다. 모든 단량체, 이량체, 및 삼량체 형태의 sCD40L이 CD40에 결합할 수 있지만, TNFR 패밀리의 공통적인 특징인 세포 표면 CD40의 올리고머화를 통해 삼량체 형태의 sCD40L이 가장 강력한 생물학적 활성을 갖는다. CD40의 최고 발현은 항원 제시 세포 (APC), 예컨대 B 세포, 대식세포 및 수지상 세포에서 관찰된 반면, 상기 수용체의 보다 낮은 발현은 간질 세포 및 흉선 상피를 비롯한 다양한 다른 세포 종류에서 관찰된다. CD40-CD40L 상호작용은 정상적인 T-B 세포 상호작용, 예를 들어 증가된 동시-자극, T-세포 프라이밍 (priming), 시토카인 생산, 항체-클래스 전환 및 친화도 성숙, 및 항체 및 자가항체 생산에 필수적이다.
면역 및 염증 반응에서 CD40-CD40L 상호작용의 중대한 역할로 인해 이들은 병리학적 면역-염증 과정의 치료를 위한 유망한 표적이 되었다. 특이적 CD40L 모노클로날 항체 (mAb)에 의한 CD40-CD40L 상호작용의 차단은 영장류에서 동종이식편 거부를 성공적으로 방지하고, 동물 모델에서 자가면역 질환 및 아테롬성동맥경화증을 치료한다 (문헌 [Montgomery et al., Transplantation 74: 1365-1369 (2002)]).
인간에서, 2가지 상이한 항-CD40L mAb 클론이 상이한 자가면역 질환의 치료를 위한 임상 시험에서 사용되었다 (문헌 [Maribel et al., Mol. Immunol. 45: 937-44 (2008)]). 그러나, 모노클로날 항체는 혈전색전성 (TE) 합병증, 예컨대 아테롬혈전성 중추 신경계 사례, 심근 경색, 폐 색전증, 및 심부 정맥 혈전증의 비정상적으로 높은 발생률을 보일 수 있다. 예를 들어, 항-CD40L mAb 클론 hu5c8 (항-CD40L mAb, 바이오겐 (Biogen))의 유용성은 TE 합병증의 비정상적으로 높은 발생률에 의해 제한된다. 이들 항체에 의한 TE는, 라이게이션되어 FcgRIIa 수용체를 통해 이웃하는 혈소판을 응집시켜 혈전 형성을 일으키는, mAb와 혈소판 상의 막-결합형 CD40L, 또는 혈소판으로부터 누출된 sCD40L과의 보다 고차의 면역 복합체 (IC) 형성에 의해 일어나는 것으로 생각된다. 혈전색전증 위험으로 인해 모든 진행중인 임상 시험이 중지되었다 (문헌 [Boumpas et al., Arthritis & Rheumatism 48: 719-727 (2003)]).
혈소판 응집을 일으켜 혈전색전증을 야기할 가능성이 적은 항-CD40L 항체 길항제가 임상 환경에서 여전히 필요하다. 인간 CD40L에 특이적으로 결합하는 신규한 항체 폴리펩티드를 제공한다. 항체 폴리펩티드는 유리하게는 혈소판 응집을 일으키지 않는다. 항체 폴리펩티드는 자가면역 질환, 이식 거부 및 알레르기 반응을 비롯하여 CD40L 활성화가 관련된 질환의 치료에서 유용하다. 항체 폴리펩티드는 가변 도메인을 포함한다. 예시적인 항체 폴리펩티드는 단일 가변 도메인을 함유하는 도메인 항체 (dAb)의 형태이다. 대안적으로, dAb는 예를 들어 인간 혈청 알부민 (HSA)과 같은 또 다른 항원에 결합할 수 있는 제2 가변 도메인을 포함하는 이중-특이적 시약일 수 있다.
인간 CD40L에 특이적으로 결합하는 제1 가변 도메인을 포함하는 항체 폴리펩티드를 제공하며, 여기서 제1 가변 도메인은 BMS2h 계통 (lineage)으로부터 선택된 가변 도메인 중의 하나의 아미노산 서열을 포함한다. 추가로, 인간 CD40L에 특이적으로 결합하는 제1 가변 도메인을 포함하는 단리된 항체 폴리펩티드를 제공하며, 여기서 CD40L은 서열 1의 아미노산 서열을 포함하고, 제1 가변 도메인의 아미노산 서열은 (a) BMS2h-572-633의 CDR1 영역과 3개 이하의 아미노산이 상이한 CDR1 영역, (b) BMS2h-572-633의 CDR2 영역과 3개 이하의 아미노산이 상이한 CDR2 영역, (c) BMS2h-572-633의 CDR3 영역과 3개 이하의 아미노산이 상이한 CDR3 영역, (d) BMS2h-572-633의 FR1 영역과 3개 이하의 아미노산이 상이한 FR1 영역, (e) BMS2h-572-633의 FR2 영역과 3개 이하의 아미노산이 상이한 FR2 영역, (f) BMS2h-572-633의 FR3 영역과 3개 이하의 아미노산이 상이한 FR3 영역, 및 (g) BMS2h-572-633의 FR4 영역과 3개 이하의 아미노산이 상이한 FR4 영역을 포함하며, 항체 폴리펩티드는 100 pM 내지 100 nM의 EC50으로 CD40에 대한 CD40L의 결합을 억제한다. 또한, 제1 가변 도메인의 아미노산 서열이 (a) BMS2h-572-633의 CDR1 영역과 3개 이하의 아미노산이 상이한 CDR1 영역, (b) BMS2h-572-633의 CDR2 영역과 3개 이하의 아미노산이 상이한 CDR2 영역, (c) BMS2h-572-633의 CDR3 영역과 3개 이하의 아미노산이 상이한 CDR3 영역을 포함하는 항체 폴리펩티드를 제공한다. 대안적으로, 제1 가변 도메인의 아미노산 서열은 BMS2h-572-633의 아미노산 서열과 10개 이하의 아미노산이 상이할 수 있다. 더욱이, 제1 가변 도메인의 아미노산 서열은 BMS2h-572-633의 아미노산 서열과 5개 이하의 아미노산이 상이할 수 있다. 제1 가변 도메인의 아미노산 서열은 또한 BMS2h-572-633의 아미노산 서열과 2개 이하의 아미노산이 상이할 수 있다. 대안적으로, 제1 가변 도메인은 BMS2h-572-633의 아미노산 서열과 1개 아미노산이 상이하다.
또한, BMS2h-572의 계통 군으로부터 선택되는 항체 폴리펩티드가 제공되며, 여기서 제1 가변 도메인의 아미노산 서열은 다음을 추가로 포함한다: (a) 서열 Trp-X1-Leu-Met-Gly (서열 2)을 갖는 CDR1 영역 (여기서 X1은 Glu 또는 Gln임); (b) 서열 Gly-Ile-Glu-Gly-Pro-Gly-Asp-Val-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly (서열 3)을 갖는 CDR2 영역; 및 (c) 서열 Lys-X2-Y2-Z2-Ser-Asp-Tyr (서열 4)을 갖는 CDR3 영역 (여기서 X2는 Asp 또는 Glu이고, Y2는 Ala 또는 Ser이고, Z2는 Lys, Asn, 또는 Arg임). 또한, 제1 가변 도메인의 아미노산 서열이 추가로 다음을 포함하는 항체 폴리펩티드를 제공한다: (a) 서열 Glu-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly-Leu-Val-Gln-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Asn (서열 5)을 갖는 FR1 영역; (b) 서열 Trp-X1-Arg-Gln-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Trp-Val-Ser (서열 6)을 갖는 FR2 영역 (여기서, X1은 Ala 또는 Val임); (c) 서열 Arg-Thr-Phe-Ile-Ser-Arg-Asp-Asn-Ser-Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-Ala-Val-Tyr-Tyr-Cys-Val-Lys-Val-Gly (서열 7)을 갖는 FR3 영역; 및 (d) 서열 Arg-Gly-Gln-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser (서열 8)을 갖는 FR4 영역. 대안적으로, 항체 폴리펩티드의 제1 가변 도메인은 BMS2h-572-633의 아미노산 서열을 포함할 수 있다.
또한, 다음 컨센서스 (consensus) 서열을 갖는 제1 가변 도메인을 포함하는, BMS2h-719의 계통 군으로부터 선택되는 항체 폴리펩티드를 제공한다:
Figure pct00001
(서열 9) (여기서, X1은 Lys 또는 Asn이고; Y1은 Arg, Lys, Ser, 또는 Thr이고; Z1은 is Met 또는 Gln이고; A1은 Asp 또는 Glu이고; B1은 Asp 또는 Glu이고; C1은 Phe, Met, 또는 Leu이다).
또한, 다음 컨센서스 서열을 갖는 제1 가변 도메인을 포함하는, BMS2h-503의 계통 군으로부터 선택되는 항체 폴리펩티드를 제공한다:
Figure pct00002
(서열 10) (여기서, X1은 His 또는 Asp임).
또한, 다음 컨센서스 서열을 갖는 제1 가변 도메인을 포함하는, BMS2h-116의 계통 군으로부터 선택되는 항체 폴리펩티드를 제공한다:
Figure pct00003
(서열 11) (여기서, X1은 Ser 또는 Tyr이고; Y1은 Leu 또는 Phe이고; Z1은 Thr 또는 Lys이고; A1은 Lys, Arg, 또는 Gln임).
또한, 인간 CD40L에 특이적으로 결합하는 제1 가변 도메인을 포함하는, 도메인 항체 (dAb)인 항체 폴리펩티드를 제공한다. 항체 폴리펩티드는 제1 가변 도메인 및 Fc 도메인을 포함하는 융합 폴리펩티드일 수 있다. 대안적으로, 융합 폴리펩티드는 IgG4 Fc 도메인을 포함할 수 있다. 융합 폴리펩티드는 IgG1 Fc 도메인을 또한 포함할 수 있다. 융합 폴리펩티드는 IgG1 Fc 도메인을 또한 포함할 수 있다. 대안적으로, 융합 폴리펩티드는 CT-긴 (Long) 도메인을 포함할 수 있다. 융합 폴리펩티드는 CT-짧은 (short) 도메인을 또한 포함할 수 있다. 대안적으로, 융합 폴리펩티드는 N297Q 긴 Fc 도메인을 포함할 수 있다. 융합 폴리펩티드는 대안적으로 N297Q 짧은 Fc 도메인을 포함할 수 있다.
또한, 인간 CD40L에 특이적으로 결합하는 제1 가변 도메인을 포함하는 항체 폴리펩티드가 제공되며, 여기서 항체 폴리펩티드는 제2 항원에 특이적으로 결합하는 제2 가변 도메인을 추가로 포함하고, 제2 항원은 인간 CD40L 이외의 다른 항원이다. 제2 항원은 분화 클러스터 (cluster of differentiation) (CD) 분자 또는 주요 조직적합성 복합체 (MHC) 클래스 II 분자일 수 있다. 대안적으로, 제2 항원은 혈청 알부민 (SA)일 수 있다.
본원에 제공된 임의의 항체 폴리펩티드를 코딩하는 핵산을 또한 제공한다. 추가로, 핵산을 포함하는 벡터가 고려된다. 단리된 숙주 세포는 상기 벡터를 포함할 수 있다.
치료 유효량의 본원에서 제공되는 항체 폴리펩티드 및 제약상 허용되는 담체를 포함하는 제약 조성물을 제공한다. 제약 조성물은 면역억제/면역조절제 및/또는 항염증제를 추가로 포함할 수 있다.
면역 질환의 치료를 필요로 하는 환자에게 치료 유효량의 본원에 기재된 제약 조성물을 투여하는 것을 포함하는, 상기 환자의 면역 질환의 치료 방법을 제공한다. 예시적인 방법은 제약 조성물을 면역억제/면역조절제 및/또는 항염증제와 조합하여 투여한다. 면역 질환은 자가면역 질환 또는 이식편-관련 질환일 수 있다. 대안적으로, 면역 질환은 이식편-관련 질환이다. 더욱이, 이식편-관련 질환은 실질 기관, 조직 및/또는 세포 이식 거부를 포함할 수 있다. 대안적으로, 이식편-관련 질환은 이식편 대 숙주 질환 (GVHD)이다. 이식편-관련 질환은 추가로 급성 이식 거부일 수 있다. 대안적으로, 이식편-관련 질환은 만성 이식 거부일 수 있다.
또한, 제약 조성물이 CTLA4 돌연변이체 분자와 공투여되는, 이식편-관련 질환의 치료 방법을 제공한다. CTLA4 돌연변이체 분자는 L104EA29Y-Ig (벨라타셉트)일 수 있다.
면역 질환의 치료를 필요로 하는 환자에게 치료 유효량의 본원에 제공된 제약 조성물을 투여하는 것을 포함하는, 상기 환자의 면역 질환의 치료 방법이 제공되고, 여기서 면역 질환은 애디슨병 (Addison's disease), 알레르기, 강직성 척추염, 천식, 아테롬성동맥경화증, 귀의 자가면역 질환, 눈의 자가면역 질환, 자가면역 간염, 자가면역 이하선염, 결장염, 관상동맥 심장 질환, 크론병 (Crohn's disease), 제1형 및/또는 제2형 당뇨병을 포함하는 당뇨병, 부고환염, 사구체신염, 그레이브스병 (Graves' disease), 길랑-바레 (Guillain-Barre) 증후군, 하시모토병 (Hashimoto's disease), 용혈성 빈혈, 특발성 혈소판감소성 자반증, 염증성 장 질환, 재조합 약물 제품에 대한 면역 반응, 전신 홍반성 루푸스, 남성 불임증, 다발성 경화증, 중증 근무력증, 천포창, 건선, 류마티스성 열, 류마티스 관절염, 사르코이드증, 경피증, 쇼그렌 (Sjogren) 증후군, 척추관절병증, 갑상선염, 이식 거부, 혈관염, AIDS, 아토피성 알레르기, 기관지 천식, 습진, 나병, 정신분열증, 유전성 우울증, 조직 및 장기의 이식, 만성 피로 증후군, 알츠하이머병 (Alzheimer's disease), 파킨슨병 (Parkinson's disease), 심근 경색, 졸중, 자폐증, 간질, 아르투스 (Arthus) 현상, 아나필락시스, 알콜 중독, 및 약물 중독으로 이루어진 군으로부터 선택된다. 대안적으로, 면역 질환은 중증 근무력증, 특발성 혈소판감소성 자반증, 또는 전신 경화증일 수 있다.
면역 질환이 존재하거나 발생할 위험이 있는 환자의 치료를 위한 의약의 제조에 있어서, 본원에 개시된 단리된 항체 폴리펩티드의 용도를 또한 제공한다. 면역 질환의 적어도 하나의 증상의 완화를 필요로 하는 환자에서 상기 완화를 위한 의약의 제조에 있어서, 본원에 개시된 단리된 항체 폴리펩티드의 용도를 추가로 제공한다.
제1 가변 도메인을 포함하는 단리된 항체 폴리펩티드를 추가로 제공하며, 여기서 상기 항체 폴리펩티드는 인간 CD40L에 특이적으로 결합하고, CD40L은 서열 1의 아미노산 서열을 포함하고, 항체 폴리펩티드는 BMS2h-572-633의 결합과 경쟁하고, 항체 폴리펩티드는 100 pM 내지 100 nM의 EC50으로 CD40에 대한 CD40L의 결합을 억제한다. 한 측면에서, 제1 가변 도메인은 BMS2h-572, BMS2h-719, BMS2h-503, 및 BMS2h-116으로 이루어진 계통 군으로부터 선택되는 하나의 항체 폴리펩티드의 아미노산 서열을 포함한다. 또 다른 측면에서, 제1 가변 도메인은 BMS2h-572-6, BMS2h-572-608, BMS2h-572-614, BMS2h-572-619, BMS2h-572-633, BMS2h-572-634, BMS2h-572-635, BMS2h-719-2, BMS2h-719-202, BMS2h-719-203, BMS2h-719-213, BMS2h-719-214, BMS2h-719-215, BMS2h-719-218, BMS2h-719-225, BMS2h-503-1, BMS2h-503-2, BMS2h-116-1312, BMS2h-116-1313, 또는 BMS2h-116-1320에 적어도 95% 동일한 아미노산 서열을 포함한다. 또 다른 측면에서, 제1 가변 도메인은 BMS2h-572-6, BMS2h-572-608, BMS2h-572-614, BMS2h-572-619, BMS2h-572-633, BMS2h-572-634, BMS2h-572-635, BMS2h-719-2, BMS2h-719-202, BMS2h-719-203, BMS2h-719-213, BMS2h-719-214, BMS2h-719-215, BMS2h-719-218, BMS2h-719-225, BMS2h-503-1, BMS2h-503-2, BMS2h-116-1312, BMS2h-116-1313, 또는 BMS2h-116-1320의 아미노산 서열을 포함한다.
도 1a는 아바타셉트 IgG1로부터의 변형된 Fc 테일 (tail)에 융합된 VH 가변 도메인 BMS2h-572-633을 포함하는 도메인 항체를 도시한 것이다.
도 1b는 가변 도메인 BMS2h-572-633의 아미노산 서열 (서열 1355)을 보여준다. Fc 융합 단백질은 분자량 77,984 달톤의 이량체이고, 여기서 각각의 폴리펩티드 사슬은 354개의 아미노산으로 이루어진다. 가변 도메인은 링커에 의해 인간 IgG1의 돌연변이된 Fc 구축물에 융합되고, 3개의 시스테인 잔기는 세린으로 치환되고, 1개의 프롤린은 세린 잔기로 치환된다.
도 2는 CD40-40L 경로의 작용 모델을 도시한 것이다. 상부 패널은 T 세포와 APC 사이의 초기 접촉 단계를 보여준다. 조기 CD28-CD80 상호작용 (신호 2)과 함께 pMHC 복합체의 T 세포 수용체 (TCR) 결합 (engagement)에 의해 유도되는 초기 접촉 (신호 1)은 삼량체 CD40L의 세포 표면 발현을 위해 충분하다 (하부 패널). CD40L에 의한 CD40의 결합은 회색 상자에 개요가 설명된 많은 생물학적 반응을 야기한다.
도 3은 다양한 Fc 도메인의 서열 (각각 제시되는 순서로 서열 1356-1361)을 제공한다. 링커 영역은 상자 내에 제시된다.
도 4는 다양한 Fc-포맷된 (formatted) 도메인 항체 (각각 제시되는 순서로 서열 1362-1365)의 예를 보여준다. 링커 영역은 상자로 표시된다.
도 5는 25℃에서 스트렙타비딘 SPR 센서 칩에 포획된 biot-IZ-hCD40L에 대한 12.5-0.39 nM BMS-986004 (2:1 희석 계열)의 결합에 대한 SPR 센서그램 (sensorgram) 데이터를 도시한 것이다. 유색 선은 이중 참조 (double-referenced) 센서그램 데이터를 보여주고, 흑색 선은 데이터에 피팅된 1:1 랭뮤어 (Langmuir)를 보여주고, 여기서 결합력 (avidity)-영향받은 겉보기 Kd 값은 0.11 nM이다.
도 6은 19 μM IZ-hCD40L의 2 μM BMS-986004 내로의 적정 (흑색) 또는 18 μM BMS-986004의 2 μM IZ-hCD40L 내로의 적정 (청색)에 대한 ITC 데이터를 보여준다. 몰비 (겉보기 화학양론)는 IZ-hCD40L 삼량체의 몰당 및 2가 BMS-986004 Fc-이량체의 몰당 규정된다. 가로축 상의 당량점으로서 얻은 몰비 값은 1몰 초과의 BMS-986004가 IZ-hCD40L 삼량체 1몰당 결합할 수 있다고 제시하지만; 복합체에 대한 정확한 구조적 모델은 ITC 데이터만으로는 결정될 수 없다. 정사각형은 결합 데이터의 집적 히트 (integrated heat)를 나타내고, 실선은 "2 세트의 부위 모델"에 대한 최적 맞춤 (best fit)을 나타낸다.
도 7은 마우스 CD40L 대용물 (surrogate) dAb-Fc의 생체내 효능 (KLH-유도된 항체 반응)을 보여준다.
도 8은 마우스 dAb BMS-2m-126-24-Fc 및 항체 MR-1이 마우스에서 TNBS-유도된 결장염을 억제함을 보여준다.
도 9는 BMS-2m-126-24-Fc 및 CTLA4-Ig가 심장 동종이식편의 생존을 연장하기 위해 상승작용 방식으로 작용함을 보여준다.
도 10은 항-CD40 모노클로날 항체-매개된 혈소판 응집에 대한 가상 모델을 제공한다.
도 11a는 원숭이에서 11 mg/kg의 IV 투여 후에 BMS-986004의 혈장 농도 대 시간 프로파일을 보여준다.
도 11b는 원숭이에서 2 mg/kg의 IV 투여 후에 BMS-986003의 혈장 농도 대 시간 프로파일을 보여준다.
도 12는 BMS-986003 (원숭이에서 0.2, 2 및 20 mg/kg의 SC 투여 후) 및 5c8 IgG1 (원숭이에서 20 mg/kg의 IV 투여 후)의 혈장 농도 대 시간 프로파일을 보여준다.
도 13은 마우스에 대한 1 mg/kg IV 및 SC 투여, 및 10 mg/kg SC 투여 후에 BMS-2m-126-24-CT의 혈장 농도 대 시간 프로파일을 보여준다.
도 14는 BMS-986003 및 5c8-IgG1 혈장 노출 및 항-KLH 항체 반응 (IgG 역가)의 PK/PD 모델링 (modeling)을 보여준다.
도 15는 말초 혈액 단핵 세포 (PBMC)에 대한 BMS-986004 혈장 노출 및 생체 외 RO의 PK/PD 모델링을 보여준다.
도 16은 IV.3이 인간 혈액에서 혈소판의 5c8/sCD40L IC-매개된 활성화를 차단함을 보여준다.
도 17은 인간 혈액에서 혈소판 활성화에 대한 Fc 변이체의 효과를 보여준다.
도 18은 FcgRIIa 다형성에 대해 유전자형이 결정된 인간 공여자로부터의 혈액에서 5c8-CT/sCD40L IC를 사용한 혈소판의 활성화를 보여준다.
도 19는 인간 공여자로부터의 혈액에서 다양한 항체에 의한 혈소판 활성화를 도시한 것이다.
도 20은 hFcgRIIa-발현 트랜스제닉 (transgenic) 마우스에서 BMS-986003를 비롯한 다양한 항체에 의한 혈소판 활성화의 수준을 보여준다.
도 21, 22, 23, 및 24는 각각 계통 BMS2h-572, BMS2h-719, BMS2h-503, 및 BMS2h-116으로부터의 대표적인 도메인 항체 폴리펩티드의 ClustalW2 정렬을 보여준다. 도 21은 제시된 순서대로 각각 서열 243, 251, 257, 262 및 274-276을 개시하고, 도 22는 제시된 순서대로 각각 서열 352, 354-355 및 357-361을 개시하고, 도 23은 제시된 순서대로 각각 서열 1087-1088을 개시하고, 도 24는 제시된 순서대로 각각 서열 970-971 및 974을 개시한다.
도 25는 1가 dAb BMS2h-503-1, BMS2h-572-6, BMS2h-719-17, 및 5c8의 1가 Fab 단편을 사용한 결합 실험에 대한 SPR 센서그램 데이터를 보여주고, 여기서 지시된 분자는 CD40L (비오티닐화된 IZ-hCD40L)에 대한 결합에 대해 서로 경쟁한다.
도 26은 CD40L 단량체 (상부의 3 패널) 또는 CD40L 삼량체 (하부의 3 패널)에 대한 BMS2h-572-619-CT-긴, BMS2h-572-633-CT-긴, BMS2h-572-6-CT-긴, BMS2h-719-202-CT-긴, BMS2h-572-608-CT-긴, BMS2h-572-634-CT-긴, BMS2h-572-614-CT-긴, BMS2h-572-635-CT-긴, 및 5c8-CT-긴 분자의 결합을 시험하는 실험에 대한 SPR 센서그램 데이터를 보여준다.
인간 CD40L에 특이적으로 결합하는 항체 폴리펩티드를 제공한다. 항체 폴리펩티드는 혈소판을 활성화시키지 않고, 항체 폴리펩티드는 CD40L 활성화가 관련된 질환, 예컨대 이식편-관련 질환 및 자가면역 질환의 치료에 유용하다. 항체 폴리펩티드는 세포 결합 검정을 이용한 일차 스크린, 이어서 하나 이상의 라운드의 오류 유발 (error-prone) 또는 축퇴성 올리고뉴클레오티드-유도 친화도 성숙을 이용하여 선택할 수 있다. 그 결과로서, CD40L에 특이적으로 결합하는 항체 폴리펩티드의 속 (genus)을 제공한다.
"계통"은 아래 실시예에서 개시되는 바와 같이 오류 유발 또는 축퇴성 올리고뉴클레오티드-유도 친화도 성숙에 의해 공통적인 전구체로부터 제조되고 CD40L에 결합할 것으로 예상되는 관련 항체 폴리펩티드의 세트이다. 항체 폴리펩티드의 명명법이 다양한 계통을 지정하기 위해 사용된다. 명칭 "BMS2h-572"는 예를 들어 인간 CD40L에 대해 생성된 계통 572의 항체 폴리펩티드를 의미한다. "계통 BMS2h-572" 항체 폴리펩티드는 BMS2h-572-1 내지 BMS2h-572-19, BMS2h-572-21 내지 BMS2h-572-24, BMS2h-572-601 내지 BMS2h-572-627, 및 BMS2h-572-630 내지 BMS2h-572-635를 포함한다.
따라서, 한 측면에서, 항체 폴리펩티드는 인간 CD40L에 특이적으로 결합하는 가변 도메인을 포함하고, 여기서 항체 폴리펩티드는 표 1 또는 표 3에 나열된 임의의 하나의 도메인 항체 (dAb)의 결합과 경쟁한다. 예를 들어, 항체 폴리펩티드는 2h 계통으로부터 선택된 dAb와 경쟁할 수 있다. dAb는 또한 예를 들어 BMS2h-116, BMS2h-503, BMS2h-572, 및 BMS2h-719, 예컨대 dAb BMS2h-572-633, BMS2h-572-608, 또는 BMS2h-572-614로 이루어진 군으로부터 선택되는 계통으로부터 선택될 수 있다. 또 다른 측면에서, 항체 폴리펩티드는 표 1 또는 표 3에 나열된 임의의 하나의 dAb처럼 인간 CD40L에 특이적으로 결합한다. 예를 들어, 항체 폴리펩티드는 예를 들어 dAb BMS2h-572-633, BMS2h-572-608, 또는 BMS2h-572-614처럼 인간 CD40L에 특이적으로 결합하는 가변 도메인을 포함할 수 있다.
항체 폴리펩티드는 단일 가변 도메인을 함유하는 도메인 항체일 수 있다. 항체 폴리펩티드는 또한 추가의 도메인, 예컨대 Fc 도메인을 포함할 수 있다. 예를 들어, 항체 폴리펩티드는 인간 혈청 알부민 (HSA)에 특이적으로 결합하는 제2 가변 도메인을 포함할 수 있다. 상기 이중 특이적 항체 폴리펩티드는 예를 들어 증가된 반감기를 가질 수 있다.
본원에서 사용되는 바와 같이, "특이적 결합"은 예를 들어 표면 플라즈몬 공명 (SPR)에 의해 측정될 때 약 1 μM 또는 그 미만의 해리 상수 (Kd)로 항체 폴리펩티드에 의한 항원의 결합을 의미한다. 적합한 검정 시스템은 비아코어(BIAcore)™ 표면 플라즈몬 공명 시스템 및 비아코어™ 동역학 평가 소프트웨어 (예를 들어, 버전 2.1)를 포함한다. 특이적 결합 상호작용에 대한 친화도 또는 Kd는 약 1 μM 또는 그 미만, 약 500 nM 또는 그 미만, 또는 약 300 nM 또는 그 미만일 수 있다.
용어 "약"은 당업계의 통상의 기술자에 의해 이해될 것이고, 이 용어가 사용되는 맥락에서 어느 정도 상이할 것이다. 일반적으로, 약은 언급된 값의 ±10%인 값의 범위를 포함한다.
본원의 상세한 설명에 따라, 다음 약어 및 정의가 적용된다. 본원에서 사용되는 바와 같이, 단수 형태 ("a", "an", 및 "the")는 명백하게 달리 제시되지 않는 한 복수의 참조물을 포함함을 유의해야 한다. 따라서, 예를 들어 "항체"의 언급은 복수의 그러한 항체를 포함하고, "투여량"의 언급은 하나 이상의 투여량 및 당업자에게 알려진 그의 동등물을 포함하다.
1. CD40L 및 CD40L 활성
인간 CD40L에 결합하는 항체 폴리펩티드를 제공한다. CD40L은 또한 CD154, gp39, TNF-관련 활성화 단백질 (TRAP), 5c8 항원, 또는 T-BAM으로도 공지되어 있다. 인간 CD40L에 대한 관련 구조적 정보는 예를 들어 UniProt 등록 번호 P29965에서 볼 수 있다. "인간 CD40L"은 다음 아미노산 서열을 포함하는 CD40L을 나타낸다:
Figure pct00004
CD40L의 서열은 또한 수스 스크로파 (Sus scrofa), 무스 무스쿨루스 (Mus musculus), 카니스 파밀리아리스 (Canis familiaris), 보스 피니 (Bos ffini), 마카카 물라타 (Macaca mulatta), 아오투스 티비르가투스 (Aotus tivirgatus), 칼리트릭스 자쿠스 (Callithrix jacchus), 세르코세부스 토르구아투스 아티스 (Cercocebus torquatus atys), 마카카 네메스트리나 (Macaca nemestrina), 래투스 노르베지쿠스 (Rattus norvegicus), 갈루스 갈루스 (Gallus gallus), 펠리스 카투스 (Felis catus), 및 수스 스크로파에서 결정되었다.
CD40L에 대한 본 발명의 항체 폴리펩티드의 결합은 CD40L 활성을 길항한다. "CD40L 활성"은 APC에 대한 MHC 분자에 의한 T 세포 수용체 자극과 함께 APC에 대한 동시자극 및 활성화, 시토카인의 존재 하에서 모든 이뮤노글로불린 이소형의 분비, B 세포 증식의 자극, 시토카인 생산, 항체 클래스 전환 및 친화도 성숙을 포함하며 이로 제한되지 않는다. 예를 들어, X-연관 고-IgM 증후군 환자는 이들의 B 세포 상에 기능적 CD40을 발현하지만, 이들의 활성화된 T 세포는 결함 CD40L 단백질을 보유하고, 이에 의해 B 세포를 활성화시키고 이뮤노글로불린 이소형 전환을 유도하는 능력이 결여된다 (문헌 [Aruffo et al., Cell 72:291-300 (1993)]).
CD40L 활성은 다른 분자와의 상호작용에 의해 매개될 수 있다. "CD40 활성"은 CD40L과 다음 분자 사이의 기능적 상호작용을 포함한다: CD40 (CD40L 수용체), α5β1 인테그린, 및 αIIbβ3. 예를 들어, CD40L은 그의 수용체인 CD40에 결합하고, 다양한 APC, 예컨대 B 세포, 대식세포, 및 수지상 세포 상에, 및 간질 세포, 혈관 내피 세포, 및 혈소판 상에서 발현된다.
본원에서 사용되는 바와 같이, 용어 "활성화시키다" 및 "활성화된"은 참조물에 비해 주어진 측정가능한 CD40L 활성의 적어도 10% 증가, 예를 들어 적어도 10%, 25%, 50%, 75%, 또는 심지어 100%, 또는 그 초과의 증가를 의미한다. CD40L 활성은 길항제의 부재 하에 비해 활성이 적어도 10%, 예시적인 실시양태에서, 적어도 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 97%, 또는 심지어 100% (즉, 검출가능한 활성이 없음) 감소하면 "길항된" 것이다. 예를 들어, 항체 폴리펩티드는 일부의 또는 모든 CD40L 활성을 길항할 수 있다. 한 실시양태에서, 항체 폴리펩티드는 B 세포 증식을 활성화시키지 않는다. 또 다른 실시양태에서, 항체 폴리펩티드는 T 세포 또는 수지상 세포 (DC)에 의한 시토카인 분비를 활성화시키지 않고, 여기서 시토카인은 IL-2, IL-6, IL-10, IL-12, IL-13, IL-17, IL-23, TNF-α, 및 IFN-γ로 이루어진 군으로부터 선택되는 적어도 하나의 시토카인이다.
2. 항체 폴리펩티드
항체 폴리펩티드는 가변 도메인을 포함한다. 한 실시양태에서, 항체 폴리펩티드는 단일 가변 도메인을 함유하는 dAb의 형태이다. 항체 폴리펩티드 디술피드 결합에 의해 서로 연결된 2개의 중쇄 (H) 및 2개의 경쇄 (L)를 포함하는 전장 항-CD40L 이뮤노글로불린 분자일 수 있다. 본 실시양태에서, 각각의 사슬의 아미노 말단 부분은 약 100-120개 아미노산의 가변 도메인 (VL 또는 VH)을 포함한다. 여기에 포함된 상보성 결정 영역 (CDR)이 주로 항원 인식을 담당하지만, 프레임워크 잔기가 에피토프 결합에 일정 역할을 할 수 있다. 각각의 중쇄의 카르복시-말단의 "절반"은 주로 이펙터 기능을 담당하는 불변 영역 (Fc)을 규정한다.
항체 폴리펩티드는 또한 CD40L에 특이적으로 결합하는 가변 도메인을 포함하는 전장 항-CD40L 이뮤노글로불린 분자의 일부를 포함하는 "단편"일 수 있다. 따라서, 용어 "항체 폴리펩티드"는 예를 들어, 항원-결합 중쇄, 경쇄, 중쇄-경쇄 이량체, Fab 단편, F(ab')2 단편, Fv 단편, 단일 사슬 Fv (scFv), 및 dAb를 포함한다. 따라서, 용어 "항체 폴리펩티드"는 재조합 조작 및 발현에 의해 제조된 폴리펩티드, 및 하이브리도마 세포 클론에 의한 천연 재조합 및 분비에 의해 생산된 모노클로날 항체를 포함한다.
경쇄는 카파 (κ) 또는 람다 (λ)로 분류되고, 당업계에 공지된 바와 같이 특정 불변 영역, 즉 CL에 의해 특성화된다. 중쇄는 γ, μ, α, δ, 또는 ε으로 분류되고, 각각 IgG, IgM, IgA, IgD, 또는 IgE로서 항체의 이소형을 규정한다. 중쇄 불변 영역은 IgG, IgD, 및 IgA에서 3개의 도메인 (CH1, CH2, 및 CH3); 및 IgM 및 IgE에서 4개의 도메인 (CH1, CH2, CH3, 및 CH4)으로 이루어진다. 항-CD40L 항체는 임의의 이뮤노글로불린 클래스 (IgA, IgD, IgG, IgM, 및 IgE)로부터 선택된 중쇄 불변 영역을 가질 수 있다.
각각의 경쇄 가변 도메인 (VL) 및 중쇄 가변 도메인 (VH)은 3개의 CDR 및 4개의 프레임워크 영역 (FR)으로 이루어지고, 이것은 아미노-말단으로부터 카르복시-말단으로 다음 순서로 배열된다: FR1, CDR1, FR2, CDR2, FR3, CDR3, 및 FR4. 경쇄의 3개의 CDR은 "LCDR1, LCDR2, 및 LCDR3"으로 언급되고, 중쇄의 3개의 CDR은 "HCDR1, HCDR2, 및 HCDR3"으로 언급된다
본원에서 사용되는 바와 같이, 용어 "Fc 도메인"은 문헌 [Kabat et al., Sequences of Immunological Interest, 5th ed., U.S. Dept. Health & Human Services, Washington, D.C. (1991)]에 따라 범위가 규정된 CH2 및 CH3 불변 도메인을 포함하는 불변 영역 항체 서열을 의미한다. Fc 도메인은 예를 들어 IgG1 또는 IgG4 Fc 영역으로부터 유래될 수 있다.
가변 도메인은 Fc 도메인에 융합될 수 있다. 다양한 Fc-포맷된 도메인 항체 및 이들의 효능의 예를 표 6에 제공한다. 도 3은 본원에 제공된 다양한 Fc 도메인의 서열을 제공한다. 링커 영역은 상자 내에 제시된다. 표 6에서 사용되는 바와 같이, "Fc"는 dAb가 인간 IgG1 짧은 Fc에 융합됨을 나타낸다. CT-L2로도 언급되는 "CT 긴 Fc"는 CTLA4로부터의 Fc를 의미한다. 밑줄친 S는 Fc 힌지 내의 디술피드를 제거하기 위해 이루어진 시스테인에서 세린으로의 점 돌연변이이다. CT-S1로도 언급되는 "CT 짧은"은 CT 긴보다 7개 아미노산이 더 짧다. N297Q-L4로도 언급되는 "N297Q 긴 Fc"는 Fc 내의 N-연결된 탄수화물을 제거하기 위해 이루어진 N297Q 돌연변이를 갖는 인간 IgG1의 Fc 도메인이다. N297Q-S3으로도 언급되는 "N297Q 짧은 Fc"는 N297Q 긴 Fc보다 7개 아미노산이 더 짧고, Fc 도메인 내의 N-연결된 탄수화물을 제거하기 위해 이루어진 N297Q 점 돌연변이를 갖는 인간 IgG1이다. "CT-Fc SP5"는 CT 긴 Fc이고, 여기서 SP5는 포유동물 발현 숙주로부터의 분비를 위해 사용되는 옥테오넥틴 신호 펩티드를 의미한다. 절단 부위는 "∧"로 표시된다. 도 4는 다양한 Fc 도메인 방식의 예를 추가로 제공한다.
가변 도메인이 Fc 도메인에 융합될 때, 가변 도메인 (dAb를 포함하는 VL 또는 VH 도메인)의 카르복실 말단은 Fc CH2 도메인의 아미노 말단에 연결 또는 융합될 수 있다. 대안적으로, 가변 도메인의 카르복실 말단은 그 자체가 Fc CH2 도메인에 융합된 CH1 도메인의 아미노 말단에 연결 또는 융합될 수 있다. 단백질은 CH1 및 CH2 도메인 사이에 힌지 영역을 전체적으로 또는 부분적으로 포함할 수 있다.
CDR은 항원과 특이적 상호작용을 형성하는 대부분의 잔기를 함유한다. 한 실시양태에서, 항체 폴리펩티드의 가변 도메인은 표 1 또는 표 3에 나열된 하나의 dAb의 CDR1, CDR2, 및 CDR3 영역과 동일한 아미노산 서열을 갖거나 또는 각각 CDR1, CDR2, 및 CDR3 영역과 1, 2, 또는 3개 아미노산이 상이한 CDR1, CDR2, 및 CDR3 영역을 포함한다. 예를 들어, 항체 폴리펩티드는 예를 들어 BMS2h-572-633, BMS2h-572-608, 또는 BMS2h-572-614의 CDR1, CDR2, 및 CDR3 영역과 동일한 아미노산 서열을 갖는 CDR1, CDR2, 및 CDR3 영역을 포함할 수 있다.
"도메인 항체" (dAb)는 항원, 예컨대 CD40L에 특이적으로 및 1가 결합할 수 있는 단일 가변 (VL 또는 VH) 도메인을 포함한다. 예를 들어, dAb는 낙타류 dAb에 특유한 VHH 구조를 가질 수 있다. "VH 도메인"은 본원에서 사용될 때 VHH 구조를 포함하는 의미이다. 또 다른 실시양태에서, VH 도메인 (본원에서 실시양태로서 제시되는 모든 특징 및 조합 포함)은 VHH 도메인 이외의 다른 것이다. dAb는 용액에서 동종- 또는 이종이량체를 형성할 수 있다. 임의의 특정 이론에 의해 제한되지 않지만, 본원에 개시된 dAb는 혈소판 응집을 야기하지 않는 것으로 생각되고, 그 이유는 돌연변이된 Fc 구축물을 함유하는 항체는 혈소판 표면 상의 FcγRIIa (CD32a로도 공지됨)에 결합하지 않고, 혈소판을 활성화시키지 않기 때문이다.
본원에서 사용되는 바와 같이, 용어 "가변 도메인"은 문헌 [Kabat et al., Sequences of Immunological Interest, 5th ed., U.S. Dept. Health & Human Services, Washington, D.C. (1991)]에 규정된 이뮤노글로불린 가변 도메인을 의미한다. 가변 도메인 내의 CDR 아미노산 잔기의 넘버링 및 배치는 잘 공지된 카바트 (Kabat) 넘버링 규정에 따라 실시된다.
용어 "인간"은 항체 폴리펩티드에 적용될 때, 항체 폴리펩티드가 인간 이뮤노글로불린으로부터 유래된 서열, 예를 들어 프레임워크 영역 및/또는 CH 도메인을 갖는다는 것을 의미한다. 서열은 서열이 (a) 인간 개체로부터 또는 인간 개체로부터의 세포 또는 세포주로부터 단리되거나; (b) 클로닝된 인간 항체 유전자 서열 또는 인간 항체 가변 도메인 서열의 라이브러리로부터 단리되거나; 또는 (c) 하나 이상의 상기 폴리펩티드로부터 돌연변이 및 선택에 의해 다양화될 때, 인간 이뮤노글로불린 코딩 서열"로부터 유래된" 것이다. 본원에서 사용되는 "단리된" 화합물은, 화합물이 자연에서 천연적으로 회합되는 적어도 하나의 성분으로부터 화합물이 제거됨을 의미한다.
항체 폴리펩티드는 다른 종, 예를 들어 마우스로부터의 항체의 투여에 의해 종종 촉발되는 항-항체 면역 반응을 크게 방지하면서 인간 환자에게 투여될 수 있다. 예를 들어, 뮤린 항체는 당업계에 공지된 절차에 따라 뮤린 CDR을 인간 가변 도메인 FR 상에 이식함으로써 "인간화"될 수 있다. 그러나, 본원에 개시된 인간 항체는 뮤린 항체 서열의 유전자 조작을 필요로 하지 않으면서 생산될 수 있다.
가변 도메인은 인간 배선 (germline) 항체 유전자 분절에 의해 코딩되는 상응하는 프레임워크 영역과 동일한 아미노산 서열을 갖는 하나 이상의 FR을 포함할 수 있다. 예를 들어, 도메인 항체는 VH 배선 유전자 분절 DP47, DP45, 또는 DP38, Vκ 배선 유전자 분절 DPK9, JH 분절 JH4b, 또는 Jκ 분절 Jκ1을 포함할 수 있다.
CD40L에 특이적으로 결합하는 능력을 보유하면서 항체 폴리펩티드 서열에 변화가 이루어질 수 있다. 구체적으로, 항체 폴리펩티드 (예를 들어, dAb)는 dAb BMS2h-572-633처럼 CD40L에 특이적으로 결합하는 기능을 보유하는 변이체 가변 도메인을 포함할 수 있다. 한 실시양태에서, 변이체 가변 도메인은 CD40L에 대한 특이적 결합에 대해 BMS2h-572-633과 경쟁할 수 있다. 아래 실시예에서 개시되는 오류 유발 친화도 성숙은 CD40L에 특이적으로 결합하는 변이체 서열을 갖는 항체 폴리펩티드를 제조하기 확인하기 위한 하나의 예시적인 방법을 제공한다.
예를 들어, 변이체 가변 도메인은 표 1 또는 표 3에 나열된 하나의 가변 도메인과 10개 이하의 아미노산 또는 그 사이의 임의의 정수 값의 아미노산이 상이할 수 있고, 여기서 변이체 가변 도메인은 CD40L에 특이적으로 결합한다. 대안적으로, 변이체 가변 도메인은 본원의 서열 목록에 나열된 서열에 비해 적어도 90% 서열 동일성 (예를 들어, 적어도 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 또는 99% 서열 동일성)을 가질 수 있다. 비-동일 아미노산 잔기 또는 2개의 서열 사이에 상이한 아미노산은 아미노산 치환, 부가, 또는 결실을 나타낼 수 있다. 2개의 서열 사이에 상이한 잔기는 2개의 서열이 임의의 적절한 아미노산 서열 정렬 알고리즘, 예컨대 BLAST에 의해 정렬될 때 비-동일 위치로서 나타난다.
한 실시양태에서, FR이 인간 배선 항체 유전자 분절에 의해 코딩되는 상응하는 FR의 아미노산 서열에 비해 1, 2, 3, 4, 또는 5개의 아미노산 차이를 포함하도록 하는 아미노산 치환이 개별적인 FR 영역에 이루어질 수 있다. 또 다른 실시양태에서, 변이체 가변 도메인은 CDR에 1 또는 2개의 아미노산 치환을 함유할 수 있다. 다른 실시양태에서, FR 및 CDR 영역에 대한 아미노산 치환이 조합될 수 있다. CD40L에 특이적으로 결합하는 대표적인 가변 도메인을 표 1 또는 표 3에 나열한다.
중쇄 및 경쇄 유전자의 VL 또는 VH 도메인의 경계에 대한 정보는 CD40L에 결합하는 것으로 알려진 항체 폴리펩티드를 코딩하는 클로닝된 중쇄 또는 경쇄 코딩 서열로부터 가변 도메인을 증폭하기 위한 PCR 프라이머를 설계하기 위해 사용될 수 있다. 증폭된 가변 도메인은 적합한 발현 벡터, 예를 들어 pHEN-1 (문헌 [Hoogenboom et al. (1991) Nucleic Acids Res. 19:4133-4137])에 삽입되고, 당업계에 공지된 기술을 사용하여 단독으로 또는 또 다른 폴리펩티드 서열과의 융합체로서 발현될 수 있다. 본원에 개시된 아미노산 및 폴리뉴클레오티드 서열을 기초로 하여, 융합 단백질은 임의의 적합한 포유동물 숙주 세포주, 예컨대 CHO, 293, COS, NSO 등에서 단지 통상적인 기술을 사용하여 생산한 후, 단백질 A 친화도 크로마토그래피, 이온 교환, 역상 기술 등을 포함하는 하나의 방법 또는 방법들의 조합을 사용하여 정제할 수 있다.
한 측면에서, 항체 폴리펩티드는 인간 CD40L에 특이적으로 결합하는 제1 가변 도메인을 포함하는 "이중 특이적" 항체 폴리펩티드이다. 이중 특이적 항체 폴리펩티드는 인간 CD40L 이외의 다른 제2 항원에 특이적으로 결합하는 제2 가변 도메인을 포함한다.
또 다른 실시양태에서, 제2 항원은 예를 들어 면역 이펙터 세포 또는 가용성 분자, 예컨대 시토카인의 세포 표면 분자일 수 있다. 이중 특이성 항체 폴리펩티드의 결합은 CD40L을 길항하고 제2 항원의 생물학적 활성을 길항하기 위해 사용될 수 있다. 면역 이펙터 세포의 세포 표면 분자는 분화 클러스터 (CD) 분자를 포함한다. 대표적인 CD 마커는 인터넷 웹사이트 http://en.wikipedia.org/wiki/List_of_human_clusters_of_differentiation (2012년 8월 8일 최종 변경) 상에 제시되어 있다. 또한, 면역 효과기 세포의 세포 표면 분자는 주요 조직적합성 복합체 (MHC) 클래스 II 분자를 포함한다. 이들 세포 표면 분자에 대한 항체는 당업계에 공지되어 있고, 이중 특이적 항체 폴리펩티드를 구축하기 위한 가변 도메인의 공급원으로 사용될 수 있다.
한 실시양태에서, 이중 특이적 리간드의 항체 폴리펩티드는 "아미노산 링커" 또는 "링커"에 의해 연결될 수 있다. 예를 들어, dAb는 아미노산 링커의 N-말단에 융합될 수 있고, 또 다른 dAb는 링커의 C-말단에 융합될 수 있다. 아미노산 링커는 임의의 길이이고 아미노산의 임의의 조합으로 이루어질 수 있고, 링커 길이는 연결된 도메인들 사이의 상호작용을 감소시키기 위해 비교적 짧을 수 있다 (예를 들어, 5개 또는 그 미만의 아미노산). 또한, 링커의 아미노산 조성은 부피가 큰 측쇄를 갖는 아미노산 또는 이차 구조를 도입할 가능성이 있는 아미노산의 수를 감소시키기 위해 조정될 수 있다. 적합한 아미노산 링커는 3, 4, 5, 6, 7, 10, 15, 20, 또는 25개 이하의 아미노산 길이를 포함하며 이로 제한되지 않는다. 대표적인 아미노산 링커 서열은 (GGGGS)n (서열 12)을 포함하고, 여기서 n은 임의의 정수 1 내지 5일 수 있다. 다른 적합한 링커 서열은 AS, AST, TVAAPS (서열 13), TVA, 및 ASTSGPS (서열 14)로 이루어진 군으로부터 선택될 수 있다.
제2 항원의 결합은 항체 폴리펩티드의 생체내 반감기를 증가시킬 수 있다. 예를 들어, 이중 특이적 항체 폴리펩티드의 제2 가변 도메인은 혈청 알부민 (SA), 예를 들어 인간 혈청 알부민 (HSA)에 특이적으로 결합할 수 있다. I에 결합하도록 포맷된 항체 폴리펩티드는 동일한 비포맷된 항체 폴리펩티드에 비해 증가된 생체내 t-α ("알파 반감기") 또는 t-β ("베타 반감기") 반감기를 가질 수 있다. t-α 및 t-β 반감기는 물질이 신체 내에서 얼마나 빨리 분배되고 제거되는지 측정한다. I에 대한 연결은 예를 들어 I에 특이적으로 결합할 수 있는 제2 가변 도메인과 항체 폴리펩티드의 융합에 의해 달성될 수 있다. 항-인간 혈청 알부민 항체는 당업계에 공지되어 있다. 예를 들어, 인터넷 웹사이트 www.abcam.com/index.html에서 이용가능한 압캠(Abcam)®, 인간 혈청 알부민 항체 ab10241, ab2406, 및 ab8940, 또는 인터넷 웹사이트 www.genwaybio.com에서 이용가능한 GenWay, ALB 항체 참조. I에 특이적으로 결합하는 가변 도메인은 임의의 이들 항체로부터 얻은 후, 당업계에 공지된 재조합 기술을 이용하여 본원의 항체 폴리펩티드에 융합될 수 있다.
대안적으로, 항체 폴리펩티드의 I에 대한 연결은 숙련된 당업자에게 잘 공지된 기술을 이용하여 항체 폴리펩티드 서열을 I 코딩 서열에 직접 융합시킴으로써 달성될 수 있다. I 코딩 서열은 예를 들어 진뱅크 (GenBank) 등록 번호 NM000477에서 이용가능한 cDNA 서열로부터 유래된 프라이머를 사용하여 PCR에 의해 얻을 수 있다.
한 실시양태에서, I-연결된 도메인 항체 조성물의 tα-반감기는 10% 또는 그 초과로 증가한다. 또 다른 실시양태에서, I-연결된 도메인 항체 조성물의 tα-반감기는 0.25시간 내지 6시간의 범위이다. 또 다른 실시양태에서, I-연결된 도메인 항체 조성물의 tβ-반감기는 10% 또는 그 초과로 증가한다. 또 다른 실시양태에서, I-연결된 도메인 항체 조성물의 tβ-반감기는 12 내지 48시간이다.
또 다른 실시양태에서, 항체 폴리펩티드는 PEG화에 의해 그의 생체내 반감기를 증가시키기 위해 포맷될 수 있다. 한 실시양태에서, PEG는 공유 연결된다. 또 다른 실시양태에서, PEG는 시스테인 또는 리신 잔기에서 항체 폴리펩티드에 연결된다. 또 다른 실시양태에서, PEG-연결된 항체 폴리펩티드의 유체역학적 크기는 적어도 24 kD이다. 또 다른 실시양태에서, 총 PEG 크기는 20 내지 60 kD이다. 또 다른 실시양태에서, PEG-연결된 도메인 항체의 유체역학적 크기는 적어도 200 kD이다.
PEG화는 N-히드록실숙신이미드 활성 에스테르, 숙신이미딜 프로피오네이트, 말레이미드, 비닐 술폰, 또는 티올을 포함하고 이로 제한되지 않는 몇몇의 PEG 부착 모이어티를 사용하여 달성될 수 있다. PEG 중합체는 소정의 위치에서 항체 폴리펩티드에 연결될 수 있거나, 도메인 항체 분자에 무작위로 연결될 수 있다. 또한, PEG화는 도메인 항체에 부착될 펩티드 링커를 통해 매개될 수 있다. 즉, PEG 모이어티는 항체 폴리펩티드에 융합된 펩티드 링커에 부착될 수 있고, 여기서 링커는 PEG 부착을 위한 부위 (예를 들어, 유리 시스테인 또는 리신)를 제공한다. 항체의 PEG 방법은 예를 들어 문헌 [Chapman, et al., "PEGylated antibodies and antibody fragments for improved therapy: a review", Adv. Drug Deliv. Rev. 54(4):531-45 (2002)]에 개시된 바와 같이 당업계에 공지되어 있다.
항체 폴리펩티드는 또한 이량체, 삼량체, 사량체, 또는 다른 다량체를 형성하도록 설계될 수 있다. 항체 폴리펩티드, 예를 들어 dAb는 융합 단백질로서 단량체의 발현, 단량체 사이의 펩티드 링커를 통한 2개 이상의 단량체의 연결, 또는 서로 직접 또는 디술피드 결합에 의한 링커를 통한, 또는 2가, 3가 또는 다가 연결 모이어티 (예를 들어, 멀티-아암 (arm) PEG)에 의한 번역 후 단량체의 화학적 연결을 포함하고 이로 제한되지 않는 당업계에 공지된 몇몇의 방법에 의해 연결되어 다량체를 형성할 수 있다. 한 실시양태에서, 다량체는 CD40의 단일 분자에 결합할 수 있다.
3. 제약 조성물 및 치료 방법
제약 조성물은 치료 유효량의 하나 이상의 항체 폴리펩티드 및 임의로 제약상 허용되는 담체를 포함한다. 제약상 허용되는 담체는 예를 들어, 물, 염수, 포스페이트 완충 염수, 덱스트로스, 글리세롤, 에탄올 등 및 이들의 조합물을 포함한다. 제약상 허용되는 담체는 융합 단백질의 저장 수명 또는 유효성을 향상시키는 보조 물질, 예컨대 습윤 또는 유화제, 보존제, 또는 완충제를 추가로 포함할 수 있다. 조성물은 투여 후에 활성 성분(들)의 신속한, 지속적인 또는 지연된 방출을 제공하도록 제제화될 수 있다. 적합한 제약 조성물 및 이의 제조 방법은 당업계에 공지되어 있다. 예를 들어, 문헌 [Remington, THE SCIENCE AND PRACTICE OF PHARMACY, A. Gennaro, et al., eds., 21st ed., Mack Publishing Co. (2005)] 참조.
제약 조성물은 면역억제/면역조절제 및/또는 항염증제를 추가로 포함할 수 있다. 상기 치료를 필요로 하는 환자에서 면역 질환의 치료 방법은 환자에게 치료 유효량의 제약 조성물을 투여하는 것을 포함할 수 있다. CD40L-매개된 T 세포 활성화의 길항은 예를 들어 자가면역, 이식 거부, 또는 알레르기 반응 동안 발생하는 바람직하지 않은 T 세포 반응을 억제할 수 있다. CD40L-매개된 T 세포 활성화의 억제는 상기 질환의 진행 및/또는 중증도를 완화할 수 있다.
본원에서 사용되는 바와 같이, "환자"는 동물, 예를 들어 인간을 포함하는 포유동물을 의미한다. 환자는 면역 질환으로 진단될 수 있다. "치료" 또는 "치료하다" 또는 "치료하는"은 증상, 장애, 병태, 또는 질환의 진행 또는 중증도의 완화를 수반하는 과정을 의미한다. "면역 질환"은 개체에서 세포성 및/또는 체액성 면역 반응을 비롯한 면역 반응의 발생과 연관된 임의의 질환을 의미한다. 면역 질환의 예는 이식편-관련 질환, 염증, 알레르기, 및 자가면역 질환을 포함하며 이로 제한되지 않는다. 자가면역 질환은 전신 홍반성 루푸스, 다발성 경화증, 류마티스 관절염, 당뇨병, 건선, 경피증, 아테롬성동맥경화증, 염증성 장 질환, 및 궤양성 결장염을 포함하고 이로 이루어진 군으로부터 선택될 수 있다.
제약 조성물의 투여에 의해 치료될 수 있는 질환은 애디슨병, 알레르기, 강직성 척추염, 천식, 아테롬성동맥경화증, 귀의 자가면역 질환, 눈의 자가면역 질환, 자가면역 간염, 자가면역 이하선염, 결장염, 관상동맥 심장 질환, 크론병, 제1형 및/또는 제2형 당뇨병을 포함하는 당뇨병, 부고환염, 사구체신염, 그레이브스병, 길랑-바레 증후군, 하시모토병, 용혈성 빈혈, 특발성 혈소판감소성 자반증, 염증성 장 질환, 재조합 약물 제품 (예를 들어, 혈우병 환자에서의 인자 VII)에 대한 면역 반응, 전신 홍반성 루푸스, 남성 불임증, 다발성 경화증, 중증 근무력증, 천포창, 건선, 류마티스성 열, 류마티스 관절염, 사르코이드증, 경피증, 쇼그렌 증후군, 척추관절병증, 갑상선염, 이식 거부, 및 혈관염으로 이루어진 군으로부터 선택될 수 있다. 자가면역-매개된 병태는 이환된 조직이 일차 표적이고, 몇몇의 경우에 이차 표적인 병태를 포함하며 이로 제한되지 않는다. 상기 병태는 AIDS, 아토피성 알레르기, 기관지 천식, 습진, 나병, 정신분열증, 유전성 우울증, 조직 및 장기의 이식, 만성 피로 증후군, 알츠하이머병, 파킨슨병, 심근 경색, 졸중, 자폐증, 간질, 아르투스 현상, 아나필락시스, 알콜 중독, 및 약물 중독을 포함하며 이로 제한되지 않는다.
본 발명의 제약 조성물의 투여에 바람직한 적응증은 예를 들어, 면역 혈소판감소성 자반증, 전신 경화증, 중증 근무력증, 동종이식편 거부, 및 이식편-대-숙주 질환이다.
제약 조성물은 단독으로 또는 면역억제/면역조절제 및/또는 항염증제와 조합 요법으로 (즉, 동시에 또는 순차적으로) 투여될 수 있다. 상이한 면역 질환은 환자-대-환자 기준으로 결정될 수 있는, 면역 질환을 치료하기 위해 유용한 특이적인 보조 화합물의 사용을 필요로 할 수 있다. 예를 들어, 제약 조성물은 하나 이상의 적합한 아주반트, 예를 들어 시토카인 (예를 들어 IL-10 및 IL-13) 또는 다른 면역 자극제, 예를 들어 케모카인, 종양-연관 항원, 및 펩티드와 조합하여 투여될 수 있다. 적합한 아주반트는 당업계에 공지되어 있다.
예를 들어, 본원에 개시된 제약 조성물은 세포독성 T-림프구 항원 4 (CTLA4) 돌연변이체 분자, 예컨대 L104EA29Y-Ig (벨라타셉트)와 동시에 또는 순차적으로 공투여될 수 있다. CTLA4는 CD28보다 더 높은 결합력으로 CD80 (B7-1) 및 CD86 (B7-2)에 결합하고, 이들의 활성화 후에 T 세포 상에서 일시 발현되고, CD28과 CD80/86 사이의 상호작용을 방해한다 (문헌 [Oosterwegel et al., Curr. Opin. Immunol. 11: 294-300 (1999)]). 이것은 T 세포 활성화에 대한 음성 피드백 신호를 생성한다.
L104EA29Y-Ig를 포함한 CTLA4 돌연변이체 분자는 야생형 CTLA4에 비해 CD80/86에 대한 증가된 결합력을 갖는다. L104EA29Y-Ig에 의한 CD28-CD80/86 경로의 방해는 예를 들어 단독으로 또는 다른 면역억제제와 조합으로 비-인간 영장류 이식 모델에서 이식편-관련 질환의 치료를 위해 성공적으로 추진되었다 (문헌 [Larsen et al., Amer. J. Transplant. 5: 443 (2005)]). 미국 특허 출원 2010/0166774에는 L104EA29Y-Ig의 구조, 그의 생산 방법, 및 CTLA4 분자를 포함하는 제제가 기재되어 있고; 이것은 본원에 참조로 포함된다. 미국 특허 7,094,874 및 7,482,327에는 L104EA29Y-Ig의 투여 (하나 이상의 다른 약물과의 공투여 포함) 및 투여 스케줄이 추가로 개시되어 있고, 이들 특허의 개시내용은 본원에 참조로 포함된다.
임의의 적합한 방법 또는 경로가 항체 폴리펩티드 또는 제약 조성물을 투여하기 위해 사용될 수 있다. 투여 경로는 예를 들어 경구, 정맥내, 복강내, 피하, 또는 근육내 투여를 포함한다. 투여되는 항체 폴리펩티드(들)의 치료 유효 용량은 예를 들어 치료할 면역 질환의 종류 및 심도, 조합 요법의 사용, 항체 폴리펩티드(들) 또는 제약 조성물의 투여 경로, 및 환자의 체중을 비롯한 많은 인자에 의해 결정된다. 도메인 항체의 치료 유효량의 비-제한적인 범위는 환자의 체중에 대해 0.1-20 mg/kg, 및 한 측면에서, 1-10 mg/kg이다. 항체 폴리펩티드(들)의 용량은 질환 상태의 시험관내 및/또는 생체내 모델에서 CD40 길항작용을 위해 요구되는 항체 폴리펩티드(들)의 양에 의해 추가로 유도될 수 있다. 대표적인 모델은 아래에서 및 실시예에서 설명된다.
4. 시험관내 및 생체내 모델
CD40L을 길항하는 본원의 항체 폴리펩티드의 능력은 시험관내 또는 생체내 모델 시스템 중의 하나에서 시험할 수 있다. 적절한 인간, 동물, 및 세포 모델 시스템을 아래에서 설명한다. 추가의 세포 검정 시스템은 실시예에서 설명된다.
4.1. 면역성 혈소판감소성 자반증 ( ITP ) 생체내 모델:
ITP의 발병기전에서 CD40-CD40L의 잠재적인 역할은 문헌 [Patel et al., British J. Haematology 141: 545-548 (2008)]에 보고되어 있다. ITP 환자의 항혈소판 자가항체는 순환 혈소판에 결합하여 이들의 파괴를 촉진한다. 항-CD40L 항체가 ITP에서 혈소판 수를 증가시키는 것으로 생각되는 일차 메카니즘은 항-혈소판 항체를 생산하는 자가반응성 B 세포의 T-세포 기반 활성화를 차단하는 것이다. 또한, 항-CD40L 항체는 혈소판 상의 CD40L의 발현을 차단하고, 따라서 대식세포에 대한 혈소판 당단백질 항원의 자가제시를 억제할 수 있다. 더욱이, 항-CD40L mAb는 혈소판 CD40L과 다른 세포, 예컨대 최근에 인간 루푸스 환자에서 타입 1 인터페론 (IFN) 반응의 유도에 관련됨이 시사된 형질세포양 수지상 세포 (DC) 사이의 직접적인 상호작용을 억제한다 (문헌 [Duffau et al., Sci. Transl. Med. 2: 47 (2010)]).
파텔 (Patel) 등은 통상적인 요법에 불응성인 46명의 만성 ITP 인간 환자에서 2개의 인간화 항-CD40L 모노클로날 항체, 즉 hu5c8 및 IDEC-131의 효능을 입증하였다. 환자는 증가된 혈소판 수로 특징지어지는 총 24% 반응 비율을 가졌다. 이것은 ITP의 발병기전에서 CD40-CD40L의 잠재적인 역할을 입증하였다.
4.2. 루푸스 생체내 및 시험관내 모델:
사구체 및 세뇨관 CD40 발현은 증식성 신장염에서 현저하게 상향조절된다. 몇몇 연구는 인간 루푸스에서 T 세포에 의한 CD40L의 과다발현 및 상승된 가용성 sCD40L 농도를 보고하였다 (문헌 [Kimura et al., Therapeutic Apheriss and Dialysis 9: 64-68 (2005)]; [Vakkalanka et al., Arthritis & Rheumatism 42: 871-881 (1999)]).
전신 홍반성 루푸스 (SLE)는 다중 자가항체의 생산 및 B 세포 과다활성을 특징으로 하는 만성 자가면역 질환이다. 문헌 [Grammer et al., J. Clin. Invest. 112: 1506-1520 (2003)]은 인간화 항-CD40L mAb 5c8 (BG9588)을 사용한 SLE 환자의 치료 결과를 보고하였다. 또한, 문헌 [Huang et al., Arthritis & Reumatism 46: 1554-1562 (2002)] 참조. 그래머 (Grammer) 등은 CD19+ 말초 B 세포를 항-CD40L mAb를 사용한 치료 전 및 치료 후에 검사하였다고 보고하였다. 치료 전에, SLE 환자는 CD40L, CD69, CD38, CD5, 및 CD27을 발현한 활성화된 B 세포를 나타내었다. 활성화된 B 세포는 치료 동안 및 치료 후에 주변부로부터 사라졌다. 치료 전에, 활동형 SLE 환자는 정상 개체에서 발견되지 않는 순환 CD38bright Ig-분비 세포를 갖는다. 치료 동안 이들 형질 세포의 사라짐은 항-이중 가닥 DNA (항-dsDNA) Ab 수준, 단백뇨, 및 SLE 질환 활성 지수의 감소와 연관되었다. 상기 발견과 일치하게, 시험관 내에서 배양된 말초 B 세포는 자연적으로 증식하고, 항-CD40L mAb에 의해 억제되는 방식으로 Ig를 분비하였다. 또한, SLE 환자의 말초 혈액 내에 존재하는 CD38+/++IgD+, CD38+++, 및 CD38+IgD- B 세포 하위세트는 항-CD40L mAb를 사용한 치료 후에 사라졌다. 이들 결과는 함께, 활동형 SLE 환자에서 자연적인 CD40L-CD40 상호작용이 B 세포 활성화, 증식, 및 단백뇨 및 질환 활성을 매개하는 자가항체-분비 형질 세포로의 분화를 유도함을 제시한다.
증식성 루푸스 사구체신염은 증가된 수준의 항-dsDNA 항체, 감소된 혈청 C3 농도, 및 혈뇨를 특징으로 하는 증대 및 감쇠 과정을 거치는 장기적인 자가면역 질환이다. 문헌 [Boumpas et al., Arthritis & Rheumatism 48: 719-727 (2003)]은 증식성 루푸스 사구체신염의 환자에서 BG9688, 인간화 항-CD40L 모노클로날 항체의 독성 및 효능을 평가하는 II상, 다중심, 개방-표지 연구의 결과를 보고하였다. 연구는 몇몇 BG9588 프로토콜에서 환자에서 발생하는 혈전색전성 사례 때문에 조기에 종료해야 했지만, 증식성 루푸스 신장염 환자에서 짧은 항-CD40L 항체 치료 과정은 항-dsDNA 항체를 감소시키고, C3 농도를 증가시키고, 혈뇨를 감소시켰고, 이것은 약물이 면역조절 기능을 갖는다는 것을 제시한다.
4.3. 염증성 장 질환 ( IBD ) 생체내 모델:
크론병 (CD) 및 궤양성 결장염 (UC)은 주로 활성화된 CD25+ 세포, B 세포, 및 대식세포로 이루어지는 염증이 생긴 장 점막 내의 백혈구 침윤물을 특징으로 하는 IBD이다. 문헌 [Ludwiczek et al., Int. J. Colorectal Dis. 18:142-147 (2003)]은 CD 환자에서의 sCD40L의 혈장 수준이 건강한 개체에서보다 유의하게 더 높다고 보고하였다. 또한, 누공 및/또는 농양이 존재하는 CD 환자는 단순 CD 환자보다 유의하게 더 높은 수준의 sCD40L을 보였다. 또한, CD40-CD40L 경로가 IBD에서 장 상피 세포의 전염증성 (proinflammatory) 기능에 기여한다고 보고되었다 (문헌 [Borcherding et al., Am. J. Pathol. 176: 1816-1827 (2010)]). CD 환자는 또한 전신 혈전색전성의 증가된 위험을 갖고, 상기 환자로부터의 혈소판의 과다활성 상태는 그의 CD40L의 보다 높은 내인성 함량에 의한 sCD40L의 향상된 방출 때문에 발생한다 (문헌 [Menchen et al., Gut 58: 920-928 (2009)]; [Danese et al., Gut 52: 1435-1441 (2003)].
문헌 [Kasran et al., Aliment. Pharmacol. Ther. 22: 111-122 (2005)]에서는 크론병의 치료를 위한 키메라 (chimeric) 항-인간 CD40 mAb ch5D12의 용도를 조사하였다. 단일 용량, 개방-표지 용량 확대 I/Iia상 연구에서 mAb를 18명의 중등도 내지 중증 CD 환자에게 투여하였다. 18명의 환자 중에서, 13명 (또는 72%)은 항체 주입에 대해 유리한 반응을 경험하였고, 4명의 환자 (또는 22%)는 차도를 경험하였다. 항-CD40 mAb를 사용한 치료는 현미경에 의한 질환 활성 및 고유판 세포 침윤물의 강도를 감소시켰고, mAb는 잘 허용되었다.
4.4. 류마티스 관절염 ( RA ), 소아 특발성 관절염 ( JIA ), 및 건선성 관절염 ( PsA ) 생체내 모델:
류마티스 관절염은 인구의 1%까지 침범하는 우세한 특징으로서 관절내 염증이 있는 전신 자가면역 질환이다. 이 질환은 자가항체 (환형 시트룰린화 펩티드 (CCP) 또는 류마티스 인자 (RF) (이 둘은 서로 밀접하게 상호관련됨))에 대한 항체의 존재 또는 부재에 의해 임상적으로 세분될 수 있다. 문헌 [Raychaudhuri et al., Nature Genetics 40:1216-1223 (2008)]에서는 유럽인 집단에서 RA 위험 유전자위를 확인하기 위해 총 3,393명의 사례 및 12,462명의 대조군에 대해 2개의 발표된 전장 게놈 연관 (GWA) 연구의 메타-분석을 수행하였다고 보고하였다. 이들은 이전에 8개의 별개의 수집물로부터 3,929명의 자가항체-양성 RA 사례 및 5,807명의 일치된 대조군의 독립적인 반복시험에서 RA와 연관되지 않은 31개의 최상위의 짧은 뉴클레오티드 다형성 (SNP)의 유전자형을 결정하였다. 이들은 CD40 유전자 유전자위에서 공통적인 변이체를 확인하였고, 이것은 RA 발병기전에서 CD40 신호전달 경로에 대한 중심적인 역할을 시사하였다. CD40 유전자와 RA에 대한 감수성의 강한 연관성은 3,962명의 RA 환자의 큰 UK 코호트 (cohort)에 대한 또 다른 연구에서 활발하게 반복시험되었다 (문헌 [Orozso et al., Ann. Rheum. Dis. 69: 813-816 (2010)]).
CD40L의 주요 역할은 또한 소아 특발성 관절염 (JIA)의 발병기전에서 밝혀졌다 (문헌 [Prahalad et al., Pediatric Rheumatology 6: 1-8 (2008)]). JIA는 미지 원인의 관절증의 불균일한 군이다. sCD40L은 몇몇의 시토카인과 함께 JIA 아동의 혈청에서 유의하게 상승하였다. 로지스틱 회귀 (logistic regression) 분석은 sCD40L, 및 IL-6 및 TNFα가 JIA와 분명히 연관됨을 시사하였다. sCD40L은 모든 JIA 하위유형에서 상승하였고, 보다 많은 하위유형 중에서 최고 수준이었다. 이들 결과는 sCD40L을 JIA 환자의 치료 및 모니터링을 위한 잠재적인 바이오마커 (biomarker)로서 제시하였다.
또한, 건선성 관절염 (PsA) 환자, 특히 활동형 질환의 환자로부터의 활성화된 T 세포가 CD40L의 유의하게 증가된 발현을 나타냄이 입증되었다 (문헌 [Daoussis et al., Rheumatology 46: 227-231 (2007)]). 이들 결과는 PsA의 발병기전에서 CD40-CD40L 경로의 역할 및 CD40L을 선택적으로 표적화하는 요법이 PsA 환자에에 이로울 수 있음을 나타낸다.
4.5. 전신 경화증 생체내 모델:
전신 경화증 (SSc)은 피부 및 내부 내장 장기의 섬유 및 혈관 변화를 특징으로 하는 자가면역 결합 조직 장애이다. 52명의 일본인 SSc 환자를 포함하는 연구에서, 혈청 sCD40L 수준은 건강한 대조군에 비해 상승되었다 (문헌 [Komura et al., J. Reumatol. 31: 514-519 (2004)]). 또한, SSc 환자의 sCD40L의 수준은 대조군에 비해 상승한 sCD40L 수준을 가진 전신 홍반성 루푸스 (SLE) 환자에서보다 더 높았고, sCD40L 수준은 SSc 환자의 C 반응성 펩티드 수준과 분명히 연관되었다. 또한, SSc 환자로부터 배양된 T 및 B 세포에서 항-CD40L 항체를 사용한 CD40L의 차단이 항-토포이소머라제 I 항체 생산을 억제함이 보고되었다 (문헌 [Kuwana et al., J. Immunol. 15: 2703-2714 (1995)]). 이들 결과는 CD40-CD40L 상호작용의 억제가 SSc 및 SLE의 요법에서 잠재적인 치료 표적일 수 있음을 시사한다.
4.6. 아테롬성동맥경화증 생체내 모델:
몇몇 연구에서는 아테롬생성 동안 CD40-CD40L 신호전달 경로의 역할을 제안하였다. 문헌 [Mach et al., Nature 394: 200-203 (1998)]에서는 마우스에서, 모노클로날 항-CD40L 항체를 사용한 처리가 12주 동안 고-콜레스테롤 식이를 먹인, 저밀도 지단백질에 대한 수용체가 결여되는 마우스에서 아테롬성동맥경화증을 제한하였음을 입증하였다. 항체는 대동맥 아테롬성동맥경화 병변의 크기를 59% 감소시키고, 이들의 지질 함량을 79% 감소시켰다. 추가로, 항-CD40L 항체로 처리한 마우스의 아테롬은 유의하게 더 적은 대식세포 및 T 림프구를 함유하고, 혈관 세포 부착 분자-1의 감소된 발현을 보여주었다.
고-콜레스테롤 식이의 26-주 요법의 제2 이분기 동안 저밀도 지단백질 수용체-결핍 마우스의 항-CD40L 항체 처리는 대조군 처리에 비해 대동맥궁 및 특히 가슴 및 복부 대동맥 내에서 확립된 아테롬성동맥경화 병변을 회귀시키지는 않았지만 그의 추가의 진행을 유의하게 감소시켰다 (문헌 [Schonbeck et al., Proc. Natl. Acad. Sci. 97: 7458-7463 (2000)]). 더욱이, 항-CD40L 처리는 플라크 안정성에 양호한 것으로 생각되는 방식으로 아테롬의 조성을 변화시켰고, 예를 들어 대식세포 및 지질의 상대적인 함량을 감소시키고, 평활근 세포 및 콜라겐의 상대적인 함량을 증가시켰다. 이들 연구는 아테롬성동맥경화증 및 그의 합병증, 예컨대 관상 동맥 질환에서 CD40-CD40L 신호전달 경로의 중요성을 지지한다.
4.7. 동종이식편 거부 생체내 모델:
CD40-CD40L 경로를 표적화하는 것은 특히 비-인간 영장류에서 많은 공개된 이식 연구로부터 유망한 데이터에 비추어 실질 기관 이식 (SOT)의 거부 예방을 위해 오랫동안 중요하였다. 생체외 활성화된 CD4+ T 림프구 상의 감소된 CD40L 발현이 뛰어난 신장 동종이식편 기능과 상호관련됨이 입증되었다 (문헌 [Lederer et al., Int. Arch. Allergy Immunol. 133: 276-284 (2004)]). 더욱이, 몇몇 연구에서는 항-CD40L mAb가 영장류에서 급성 동종이식편 거부를 예방하고 또한 역전시킬 수 있음을 입증하였다. 예를 들어, 문헌 [Kirk et al., Proc. Natl. Acad. Sci. USA 94: 8789-8794 (1997)]에서는 신장 동종이식편을 이식한 레서스 (rhesus) 원숭이에서, 항-CD40L mAb 5C8이 단독으로 또는 CTLA4-Ig와 조합으로 무거부반응 생존을 유의하게 연장하였음을 보고하였다. CD40L-특이적 mAb hu5c8은 단독으로 또한 적당한 수의 생존가능한 췌장 섬세포를 이식한 레서스 원숭이에서 동종이형 섬세포 생착 및 장기간 인슐린 비의존성을 허용하였다 (문헌 [Kenyon et al., Proc. Natl. Acad. Sci. USA 96: 8132-8137 (1999)]). 문헌 [Preston et al., Amer. J. Transplantation 5:1032-1041 (2005)]에서는 MHC-미스매칭된 레서스 원숭이에서 신장 이식을 수행하고, 수용자를 CD40L-특이적 mAb IDEC-131, 및/또는 시롤리무스, 및/또는 예비-이식편 공여자-특이적 수혈의 조합물로 처리하였다. IDEC-131은 영장류에서 신장 동종이식편 거부를 예방하는데 매우 효과적이었다. 신장 동종이식을 시행한 시노몰구스 (cynomolgus) 원숭이에서, 항-CD40L mAb ABI793을 사용한 처리는 이식편 거부를 효과적으로 예방하였다 (문헌 [Schuler et al., Transplantation 77: 717-726 (2004)]). 동종이식편 거부를 예방하는데 추가로, CD40L-특이적 mAb는 영장류 이식 모델에서 공여자 특이적 관용 (tolerance)을 유도하였다 (문헌 [Preston et al., Amer. J. Transplantation 5:1032-1041 (2005)]; [Kenyon et al., Proc. Natl. Acad. Sci. USA 96: 8132-8137 (1999)]).
간 또는 소장 이식 후 급성 이식편 거부를 겪는 소아과 인간 환자에서, CD8+ T 세포 상의 CD40L의 발현 및 이식 거부의 위험 사이에 상관성이 관찰되었다 (문헌 [Ashokkumar et al., Amer. J. Transplantation 9: 179-191 (2009)] 및 [Ashokkumar et al., Surgery 146: 166-173 (2009)]). 이와 유사하게, 간 또는 신장 이식 이후 동종이식편 거부를 겪는 성인 환자에서, 조직학적 분석은 CD40L 발현 및 급성 또는 만성 거부 사이의 연관성을 입증하였다 (문헌 [Bartlett et al., Amer. J. Transplantation 3: 1363-1368 (2003)] 및 [Biancone et al., Nephrol. Diall. Translpant. 13: 716-722 (1998)]).
몇몇 연구는 이식에서 보다 우수한 효능을 달성하기 위해 CD40에 비해 CD40L을 표적화하는 것을 지지한다. 예를 들어, CD40에 비해 CD40L이 선택적으로 차단될 때 이식편 생존은 더 길고 더 내구성이다 (문헌 [Gilson et al., J. Immunol. 183: 1625-35 (2009)]). 더욱이, 최근의 데이터는 CD40L 차단이 이식편 생존을 촉진하기 위해 Tregs 및/또는 억제자 (suppressor) 세포의 유도를 향상시킬 수 있음을 제안한다 (문헌 [Garcia et al., J. Clin. Inv. 120: 2486-96 (2010)]). 또한, CD40L의 차단은 특히 B7 경로의 차단과 조합될 때 무기한 이식편 생존을 일으키는 오래가는 면역 관용의 유도를 나타냈지만, CD40은 그렇지 않았다 (문헌 [Kenyon et al., Proc. Natl. Acad. Sci. USA 96: 8132-8137 (1999)]; [Kawai et al., Amer. J. Transplantation 4: 1391-1398 (2004)]; [Preston et al., Amer. J. Transplantation 5:1032-1041 (2005)]; [Adams et al., J. Immunol. 174: 542-50 (2005)]). 이식편 생존을 향상시키는데 있어서 CD40-40L 및 B7-CD28 경로 차단의 상승작용은 특히 중요하고, 이것은 SOT에 대해 벨라타셉트 (CTLA4-Ig)와 조합에 대해 천연 선택으로서 본원에 개시된 도메인 항체를 제시하기 때문이다.
4.8. 이식편 -대-숙주 질환 생체내 모델:
만성 및 급성 이식편-대-숙주 질환 (cGVHD 및 aGVHD)은 이식한 공여자 세포가 이식 수용자의 신체를 공격하는, 줄기 세포 또는 골수 이식 후에 발생할 수 있는 합병증이다. 인간에서 급성 GVHD는 이식 약 60일 이내에 일어나고, 세포용해성 림프구의 작용에 의해 피부, 간 및 창자를 손상시킨다. 만성 GVHD는 나중에 일어나고, B 세포의 폴리클로날 활성화 및 Ig 및 자가항체의 과다생산을 일으키는, 주로 피부를 침범하는 전신 자가면역 질환이다.
CD40L-CD40 상호작용은 cGVHD 및 aGVHD 모두의 발생에서 중요한 것으로 보인다 (문헌 [Durie et al., J. Clin. Invest. 94: 1333-1338 (1994)]). 마우스 생체내 모델에서, 항-CD40L 항체는 다음 cGVHD-연관 현상을 차단하였다: 비장비대, 시험관내 폴리클로날 Ig 생산, 상승된 수준의 혈청 IgE 및 혈청 항-DNA 자가항체, 및 항-숙주 세포독성 T 세포의 생성. 항체 생산은 항-CD40L 항체 투여의 끝 후에도 연장된 기간 동안 억제된 상태로 남았다. 현저한 항동종이형 세포독성 T 세포 (CTL) 반응의 유도와 연관된 aGVHD가 있는 마우스에서, 항-CD40L을 사용한 처리는 H-2b-유래 CTL의 생성을 방지하였다. 연구의 결과는 CD40L-CD40 상호작용이 GVHD에서 중요하고, CD40L은 GVHD를 제어하기 위해 표적화 면역치료제로 유용한 리간드일 수 있음을 제안한다.
4.9. 중증 근무력증 생체내 모델:
중증 근무력증 (MG) 및 그의 동물 모델, 실험적 자가면역 MG (EAMG)은 골격근의 신경근육 연결부의 니코틴성 아세틸콜린 수용체 (AChR)에 대한 자가항체에 의해 유발된 T-세포 의존적 자가면역 장애이다. EAMG에서 CD40-CD40L의 역할은 CD40L (CD40L-/-) 녹아웃 (knockout) 마우스에서 나타났다 (문헌 [Shi et al., Eur. J. Immunol. 28: 3587-3593 (1998)]). CD40L 녹아웃 마우스는 EAMG 유도에 대해 완전히 내성이었고, 감소된 Th1 및 Th2 반응 및 심하게 손상된 T-세포 의존성 AChR-반응성 B 세포 반응을 보였다.
항-CD40L 항체에 의한 CD40L-CD40 신호전달의 차단은 EAMG를 억제할 수 있음이 또한 입증되었다 (문헌 [Im et al., J. Immunol. 166: 6893-6898 (2001)]). EAMG의 만성 병기에서 래트에게 제공된 항체는 자가면역 반응의 임상적 진행을 억제하고, AChR-특이적 체액성 반응 및 지연형 과민반응을 감소시켰다. 항-EAMG의 만성 병기 동안 CD40L 처리의 효과는 만성 질환인 인간 MG에 특히 관련된다. CD40L을 길항하는 것은 MG 및 다른 항체-매개된 자가면역 질환의 면역요법을 위해 이용될 수 있음이 제안된다.
5. 혈전색전증
T 세포 및 항원 제시 세포 상에서 CD40-CD40L 상호작용은 적응 면역 반응, 예컨대 B-세포 증식, 이뮤노글로불린 (Ig) 생산, 동시-자극 활성 (CD80, CD86)의 상향조절, 시토카인 생산, 및 Ig 클래스-전환을 위해 중요하다. 수용체 및 리간드는 혈소판 상에서 또한 발현되고 (표적외 (off-target) 세포 집단), 여기서 CD40은 혈소판 상에서 구성적으로 발견되는 반면, CD40L은 활성화된 혈소판 상에서 발현되고 절단되어 sCD40L이 된다 (>90%의 순환 sCD40L이 혈소판으로부터 유래한다) (문헌 [Feroni et al., Curr. Med. Chem. 14: 2170-2180 (2007)]). 적어도 3개의 항-CD40L 모노클로날 항체 (mAb)가 비-인간 영장류 (NHP)에서 수행한 임상 및/또는 비임상 연구에서 TE를 유발하였다. hu5c8 (BG9588)은 다수의 임상 시험에서 TE를 유발하였다 (루푸스 및 신장 이식)) (문헌 [Boumpas et al., Arthritis & Rheumatism 48: 719-727 (2003)]). IDEC131은 크론병 시험에서 1명의 환자에서 TE를 유발하였고, 그 시간에 진행하는 시험을 종료하였다 (문헌 [Sidiropoulus & Boumpas, Lupus 13: 391-397 (2004)]). hu5c8 및 ABI1793 (5c8로부터 상이한 에피토프에서 CD40에 결합하는)은 둘 모두 시노몰구스 또는 레서스 원숭이에서 신장 이식 연구에서 TE/혈전증을 유발하였다 (문헌 [Schuler et al., Transplantation 77: 717-726 (2004)]; [Kanmaz et al., Transplantation 77: 914-920 (2004)]; [Koyama et al., Transplantation 77: 460-461 (2004)]). 비-공개된 개시문에서, 바이오겐에서는 6-개월 동안 각각 매주 5 및 20 mg/kg를 제공한 레서스 원숭이에서 1/4 및 6/12의 혈전증 발생률을 보고하였지만, 동일한 빈도 및 지속기간으로 50 mg/kg를 제공한 시노몰구스 원숭이에서는 그렇지 않았다. 종 차이는 명료하지 않다.
가설 중 하나는 이들 항체의 투여와 연관된 TE가 활성화 및 응집을 유발하는, FcgRIIa (IgG Fc 수용체)에 대한 IC 결합에 의해 촉진된, 혈소판의 항-CD40L mab-CD40L 면역 복합체 (IC)-매개된 가교 결합에 의해 매개된다는 것이다 (도 10). 따라서, IgG의 Fc 모이어티와 FcgRIIa의 상호작용을 차단하는 것은 혈소판 가교 결합 및 혈전증을 경감시키는 것으로 예상된다. TE/혈전증에 대한 위험을 평가하기 위해 개발된 방안 및 방법을 아래 실시예에서 설명한다.
실시예
표 1은 개시된 항체 폴리펩티드에 유용한 대표적인 항-인간 CD40L VH 도메인 아미노산 서열을 나열한다. 표 2는 표 1에 나열된 VH 도메인 서열을 코딩하는 대표적인 핵산을 개시한다. 표 3은 본원의 항체 폴리펩티드를 위해 유용한 대표적인 항-인간 CD40L VK 도메인 아미노산 서열을 나열한다. 표 4는 다시 표 3에 나열된 VK 도메인 서열을 코딩하는 대표적인 핵산을 개시한다. 당업계에 공지된 바와 같이, 다수의 코돈이 동일한 아미노산을 코딩할 수 있다. 따라서, 단백질 서열을 코딩하는 핵산은 코돈 축퇴성을 갖는 핵산을 포함한다. 표 1 및 표 3에 개시된 항체 폴리펩티드는 CD40L에 특이적으로 결합한다. 이들은 아래 실시예에 설명된 반복적 초기/일차 스크리닝 및 친화도 방법을 이용하여 제조되었다.
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실시예 1
인간 항- CD40L 가변 도메인 BMS2h -2 내지 BMS2h -785의 생성
다음 실시예는 BMS2h-2 내지 BMS2h-785로 지정된 2h 계통의 항-인간 CD40L 가변 도메인의 생성을 설명한다. 파지의 표면 상에 단일 이뮤노글로불린 가변 도메인의 레퍼토리 (repertoire)의 재조합 발현 이후, 파지 레퍼토리를 고정된 표적 항원과 접촉시키고, 세척하여 결합되지 않은 파지를 제거하고, 결합된 파지를 증식시킴으로써 선택을 수행한다. 상기 공정은 종종 "패닝 (panning)"으로서 칭한다. 이것은 단일 이뮤노글로불린 가변 도메인뿐만 아니라, 디스플레이 라이브러리 상에서 발현될 수 있는 다른 항체 단편, 예를 들어 scFv, Fab, 및 Fab'의 스크리닝에 적용가능하다. 대안적으로, 파지는 접힌 구성원에 의해서만 결합되는 고정된 일반 (generic) 리간드 (예를 들어, 단백질 A 또는 단백질 L)에 대해 패닝함으로써 적합하게 접힌 구성원 변이체의 발현을 위해 예비-선택할 수 있다. 이것은 비-기능적 구성원의 비율을 감소시켜 표적 항원에 결합할 가능성이 있는 구성원의 비율을 증가시키는 이점을 가진다. 일반 리간드를 사용한 예비-선택은 예를 들어, WO 99/20749에 교시되어 있다. 파지 항체 라이브러리의 스크리닝은 예를 들어, 문헌 [Harrison et al., Meth. Enzymol. 267: 83-109 (1996)]에 일반적으로 설명되어 있다.
스크리닝은 일반적으로 고체 지지체, 예를 들어 플라스틱 튜브 또는 웰 상에, 또는 크로마토그래피 매트릭스, 예를 들어 세파로스 (Sepharose)™ (파마시아 (Pharmacia)) 상에 고정된 정제된 항원을 이용하여 수행한다. 스크리닝 또는 선택은 또한 세포의 표면과 같은 복합체 항원 상에서 수행할 수 있다 (문헌 [Marks et al., BioTechnology 11: 1145 (1993)]; [de Kruif et al., Proc. Natl. Acad. Sci. USA 92: 3938 (1995)]). 또 다른 별법은 용액 내에 비오티닐화된 항원을 결합시킨 후, 스트렙타비딘-코팅된 비드 상에 포획시키는 선택을 포함한다.
클론 BMS2h -719 및 BMS2h -7 xx 시리즈에 대한 dAb 선택:
감소하는 농도의 항원을 사용하는 3 라운드의 선택 (사용된 라이브러리 아웃풋 (output)에 따라 라운드 1에서 500 nM; 라운드 2에서 50 nM; 라운드 3에서 50 nM 또는 5 nM)을 브리스톨-마이어스 스퀴브 (Bristol-Myers Squibb)에서 제공한 비오티닐화된 (1.2 몰 비오틴/몰 CD40L) 인간 CD40L 단량체 삼중 돌연변이체 (T211E, S222Y, H224K, [108-261] 구축물 #7)에 대하여 평행으로 수행하였다. 나이브 4G 및 6G 도맨티스 (Domantis) dAb 라이브러리로부터의 파지를 선택을 개시하기 전에 아래 지시된 풀 (pool) a) 내지 g) 내로 합하였다:
a) 7 - 10개 아미노산 사이의 4G VH CDR3 길이.
b) 11 - 15개 아미노산 사이의 4G VH CDR3 길이.
c) 7 - 15개 아미노산 사이의 4G VH CDR3 길이.
d) 4G VK.
e) 7 - 9개 아미노산 사이의 6G VH CDR3 길이.
f) 10 - 15개 아미노산 사이의 6G VH CDR3 길이.
g) 6G VK.
각 라운드의 선택은 목적하는 농도의 비오티닐화된 CD40L을 파지 (상기 지시된 나이브 라이브러리 풀 중 하나로부터, 또는 후속적인 선택 아웃풋 파지) 200 ㎕ 및 2% MPBS (2% (w/v) 마벨 (Marvel)을 함유하는 포스페이트 완충 염수 [프리미어 푸즈 (Premier Foods, 영국)]) 1000 ㎕의 혼합물에 첨가하고, 회전시켜 혼합함으로써 실온에서 1시간 동안 인큐베이션하는 것을 포함하였다. 이어서, 비오티닐화된 항원 파지 복합체를 100 ㎕의 재현탁시킨 다이나비즈 (Dynabeads) M-280 스트렙타비딘 [인비트로젠 (Invitrogen, 영국)]을 첨가함으로써 포획하고, 실온에서 회전시켜 혼합하면서 5분 동안 인큐베이션하였다. 이어서, 다이나비즈를 킹피셔 (KingFisher) 자기 분리기 [써모 피셔 사이언티픽 (Thermo Fisher Scientific, 영국)]를 사용하여 회수하고, 7 x 1 ml PBST (0.1% (v/v) 폴리옥시에틸렌소르비탄 20 모노라우레이트를 함유하는 PBS [시그마-알드리치 (Sigma-Aldrich, 영국)])에 이어 1 x 1 ml PBS로 세척하였다. 세척한 다이나비즈 상에 보유된 결합된 파지를 500 ㎕의 트립신-PBS (450 ㎕ PBS에 첨가된 50 mM Tris-HCl pH 7.4, 1 mM CaCl2 내에 용해시킨 10 mg/ml 트립신 [시그마-알드리치, 영국] 50 ㎕)와 함께 인큐베이션함으로써 용리시켰다. 파지-함유 용액을 회수하고, 250 ㎕을 사용하여 37℃에서 30분 동안 1.75 ml의 대수 성장기 이. 콜라이 (E. coli) TG1 (0.4의 OD600에서)을 감염시켰다. 이. 콜라이 TG1 파지 감염된 배양액을 11,600 g에서 마이크로원심분리기 내에서 1분 동안 원심분리하고, 생성되는 세포 펠릿을 1 ml 2xTY (1 리터 내에 16 g 트립톤, 10 g 효모 추출물 및 5 g NaCl, 121℃에서 15분 동안 고압증기멸균시킴) 내에 재현탁시키고, 15 ㎍/ml 테트라사이클린을 보충한 TYE 배지를 담은 9 cm 페트리 디쉬 상에 플레이팅하였다. 플레이트를 37℃에서 밤새 인큐베이션한 후, 15% 글리세롤을 보충한 2xTY 2 ml을 각각의 플레이트에 첨가하고, 세포를 유리 스프레더 (spreader)로 느슨하게 하고 완전히 혼합하였다. 50 마이크로리터의 긁어낸 박테리아를 사용하여 15 ㎍/ml 테트라사이클린을 보충한 50 ml의 2xTY에 접종하고, 250 rpm으로 진탕하면서 37℃에서 밤새 성장시켰다. 밤샘 배양액을 3,300 g에서 15 min 동안 원심분리시켜 박테리아를 펠릿화하였다. 파지를 침전시키기 위해, 10 ml PEG/NaCl (20% 폴리에틸렌 글리콜 8000, 2.5 M NaCl)을 40 ml 상청액에 첨가하였다. 파지/PEG 용액을 혼합하고, 얼음 상에서 1 h 동안 방치한 후, 3,300 g에서 30 min 동안 4℃에서 원심분리하고, 상청액을 폐기하였다. 펠릿을 2 ml PBS 내에 재현탁시키고, 11,600 g에서 10 min 동안 마이크로원심분리기 내에서 원심분리하여 남아있는 박테리아 파편을 제거하였다. 이어서, 파지를 함유하는 생성되는 상청액을 적절한 농도의 비오티닐화된 CD40L 단량체 삼중 돌연변이체 항원에 대하여 다음 선택 라운드를 위해 사용하였다.
파지 ELISA :
선택 라운드 2 및 3 후에 모노클로날 파지 ELISA를 수행하였다. 모든 세척은 250 ㎕ PBST의 3회 세척에 이어 250 ㎕ PBS의 3회 세척을 이용하여 수행하였다. 플레이트를 0.2 M 카르보네이트-비카르보네이트 완충제, pH 9.4 내의 1 ㎍/ml 뉴트라비딘 (NeutrAvidin) [써모 사이언티픽 (Thermo Scientific, 영국)] 50 ㎕/웰로 4℃에서 밤새 코팅하였다. 플레이트를 세척한 후, 2% MPBS로 1시간 동안 실온에서 차단하였다. 이어서, 플레이트를 세척하고, 2% MPBS 내의 ~1.0 ㎍/ml 비오티닐화된 인간 CD40L 단량체 삼중 돌연변이체 50 ㎕/웰과 함께 인큐베이션하였다. 플레이트를 세척하고, 25 ㎕/웰 파지 상청액을 동일 부피의 2% MPBS에 첨가하고, 1시간 동안 실온에서 인큐베이션하였다. 플레이트를 세척하고, 결합된 파지를 2% MPBS 내에 1:5000 희석시킨 항-M13-HRP 접합체 [지이 헬쓰케어 (GE Healthcare, 영국)] 50 ㎕/웰을 사용하여 검출하고, 1시간 동안 실온에서 인큐베이션하였다. 플레이트를 세척하고, ELISA를 50 ㎕/웰 슈어블루 (SureBlue) 1-성분 TMB 마이크로웰 페록시다제 (Micro Well Peroxidase) 용액 [케이피엘 인크. (KPL Inc, 미국)]을 사용하여 발색시켰다. 동일 부피의 1 M HCl을 첨가하여 비색 반응을 중지시키고, ELISA 플레이트를 450 nm에서 판독하였다. 특이적 파지는 뉴트라비딘을 코팅하였지만 비오티닐화된 CD40L 단량체 삼중 돌연변이체가 없는 웰에 비교함으로써 확인하였다.
미디프렙 ( MidiPrep ) pDOM4 플라스미드로부터 dAb 유전자의 회수 :
다음 라운드 3 아웃풋으로부터의 dAb V-유전자를 파지 벡터 pDOM4의 DNA 제한 효소 소화에 의해 회수하였다:
a) 7 - 10개 아미노산 사이의 4G VH CDR3 길이 (50 nM 항원 농도).
b) 11 - 15개 아미노산 사이의 4G VH CDR3 길이 (50 nM 항원 농도).
c) 11 - 15개 아미노산 사이의 4G VH CDR3 길이 (5 nM 항원 농도).
d) 7 - 15개 아미노산 사이의 4G VH CDR3 길이 (50 nM 항원 농도).
e) 4G VK (50 nM 항원 농도).
f) 4G VK (5 nM 항원 농도).
g) 7 - 9개 아미노산 사이의 6G VH CDR3 길이 (50 nM 항원 농도).
h) 10 - 15개 아미노산 사이의 6G VH CDR3 길이 (5 nM 항원 농도).
약 20 ㎍의 미디프렙 [퀴아젠 (Qiagen, 영국)] DNA를 다음과 같이 SalI 및 NotI로 소화시켰다: 20 ㎕ DNA (~1 ㎍/㎕)를 1.5 ㎕ SalI (20 U/㎕) [엔이비 (NEB, 영국)] 및 3 ㎕ NotI (10 U/㎕) [엔이비, 영국], 4 ㎕ 완충제 3 [엔이비, 영국], 0.4 ㎕ BSA (10 mg/ml) [엔이비, 영국], 및 40 ㎕가 되도록 첨가한 조직 배양 등급 물 [시그마, 영국]과 혼합하였다. 샘플을 공기 인큐베이터 내에서 5시간 동안 37℃에서 인큐베이션하고, 그 후 소화시킨 dAb 유전자를 2% 아가로스 겔 [이-겔 (E-gel), 인비트로젠, 영국] 상에서 소화 믹스를 진행시킴으로써 단리하고, 적절한 DNA 밴드를 절제하고, PCR 정제 키트 [퀴아젠, 영국]를 사용하여 세정하였다. 정제된 V-유전자를 SalI 및 NotI 이중 소화시킨 pDOM5 발현 벡터 내로 라이게이션하였다.
가용성 dAb ELISA :
결합 dAb는 다음과 같이 확인하였다. 가용성 dAb 발현 벡터 pDOM5 내로 클로닝된 dAb V-유전자를 함유하는 96개의 개별 콜로니를 각각의 아웃풋으로부터 OnEx 자가유도 배지를 함유하는 200 ㎕ 테리픽 브로쓰 (Terrific Broth) [노바겐 (Novagen, 영국)] 내로 집어넣고, 기체 투과성 접착 플라스틱 스트립 (strip)으로 밀봉한 코스타 (Costar) 96 웰 세포 배양 클러스터 [코닝 인코포레이티드 (Corning Incorporated, 미국)] 내에서 250 rpm에서 진탕하면서 37℃에서 밤새 인큐베이션하였다. 배양액을 원심분리하여 세포를 펠릿화하고, 상청액을 항원 결합 ELISA에 의해, CD40L 단량체 삼중 돌연변이체 및 IZ-CD40L 돌연변이체 (이소류신 지퍼 (zipper) 삼량체화 도메인을 함유한 CD40L, 브리스톨-마이어스 스퀴브에서 제공함)에 결합된 dAb에 대해 검정하였다. 맥시소프 (MaxiSorp) 96 웰 이뮤노플레이트 [눈크 (Nunc, 미국)]를 4℃에서 0.2 M 카르보네이트-비카르보네이트 완충제, pH 9.4 중의 1 ㎍/ml 뉴트라비딘 50 ㎕/웰을 사용하여 밤새 코팅하였다. 모든 세척은 파지 ELISA에 대해 설명된 바와 같았다. 플레이트를 1시간 동안 실온에서 1% 트윈 (Tween) 20을 함유하는 PBS 200 ㎕로 차단하였다. 이어서, 플레이트를 세척하고, 1시간 동안 실온에서 PBST 중의 1 ㎍/ml 비오티닐화된 인간 CD40L 단량체 삼중 돌연변이체 또는 PBST 중의 1 ㎍/ml 비오티닐화된 인간 IZ-CD40L 돌연변이체 (두 항원 모두 브리스톨-마이어스 스퀴브에서 공급함) 50 ㎕/웰과 함께 인큐베이션하였다. ELISA 플레이트를 세척하고, dAb-함유 배양 상청액을 1,800 g에서 10 min 동안 4℃에서 원심분리에 의해 청정화한 후, 동일 부피의 PBST를 첨가한 ELISA 플레이트에 첨가하였다 (30 ㎕/웰). 플레이트를 1시간 동안 실온에서 인큐베이션한 후 세척하였다. 결합된 dAb는 PBST 내에 1:2000 희석한 9E10 [항-myc IgG, 시그마-알드리치, 영국] 50 ㎕/웰을 첨가하고 1시간 동안 실온에서 인큐베이션함으로써 검출하였고; 이어서, ELISA 플레이트를 세척하고, PBST 내에 1:2000 희석한 항-마우스 Fc-HRP [시그마-알드리치, 영국] 50 ㎕/웰을 첨가하고 1시간 동안 실온에서 인큐베이션하였다. 플레이트를 세척하고, ELISA를 50 ㎕/웰 슈어블루 1-성분 TMB 마이크로웰 페록시다제 용액 [케이피엘 인크., 미국]을 사용하여 발색시키고, 색상을 발색시켰다. 동일 부피의 1 M HCl의 첨가에 의해 비색 반응을 중지시키고, ELISA 플레이트를 450 nm에서 판독하였다. 항원 결합 dAb는 인간 CD40L 단량체 삼중 돌연변이체 및 인간 IZ-CD40L 돌연변이체 웰로부터 신호 강도를 항원을 함유하지 않은 대조군 웰과 비교함으로써 확인하였다.
50 ml 규모에서 dAb 의 발현 & 정제 :
특유한 (unique) dAb는 DNA 서열분석 ELISA 양성 클론에 의해 확인하였다. 확인된 특유한 dAb는 다음 물질을 첨가한, 250 ml 배플이 장치된 플라스크 내에서 다음과 같이 발현시켰다:
a) 50 ml의 테리픽 브로쓰 [시그마-알드리치, 영국].
b) 100 ㎍/ml 카르베니실린 [시그마-알드리치, 영국].
c) 1적의 소포제 A204 [시그마-알드리치, 영국].
d) 노바겐 밤샘 발현 자가유도 키트 [노바겐, 영국].
신선한 융합성 9 cm 직경 아가 플레이트로부터 또는 목적하는 dAb 클론의 글리세롤 원액으로부터 박테리아 스크레이프 (scrape)을 사용하여 테리픽 브로쓰에 접종한 후, 플라스크를 밀리랩 (Milliwrap) PTFE 막 [밀리포어 (Millipore, 영국)]으로 밀봉하고, 30℃에서 250 rpm에서 진탕하면서 48 hrs 동안 인큐베이션하였다. 박테리아 밤샘 배양액을 원심분리에 의해 청정화하고, VH 또는 VK dAb를 각각 스트림라인 (Streamline) 단백질 A [지이 헬쓰케어, 영국] 또는 단백질 L 아가로스 [사내에서 생성함]를 사용하여 정제하였다. 생성되는 정제된 단백질을 어떠한 클론이 CD40에 대한 CD40L의 결합을 억제할 수 있는지 결정하기 위해 RBA에 의해 검정하였다.
CD40L 비드 수용체 결합 검정 :
억제성 dAb는 정제된 dAb를 CD40L 비드 수용체 결합 검정 (RBA)으로 스크리닝함으로써 초기에 확인하였다. 스페로 (Sphero) 스트렙타비딘 폴리스티렌 비드 (0.5% w/v, 6.7 ㎛ 직경) [색손 (Saxon, 유럽)]를 제조자의 지시에 따라 제조하고 세척하였다. 이어서, 비드를 11,600 g에서 1분 동안 펠릿화하고, 상청액을 폐기하고, 비드를 볼텍싱에 의해 1 ml PBS 내에 재현탁시켰다. 세척 단계를 2회 더 반복하고, 상청액을 폐기하고, 비드를 PBS 내의 비오티닐화된 인간 IZ-CD40L 1 ml (0.5 mg/ml) 내에 재현탁시키고, 회전시키면서 실온에서 밤새 인큐베이션하였다. 인큐베이션 후에, 비드를 펠릿화하고, 앞에서와 같이 1 ml PBS로 3회 세척한 후, 0.1% 소 혈청 알부민 (BSA)을 함유하는 PBS 0.5 ml 내에 재현탁시켰다. 이어서, 항원 코팅된 비드를 사용하기 전에 0.1% BSA를 함유하는 PBS 내에 1:10 희석하였다. RBA 검정을 위한 시약을 384-웰 흑색 측면의 바닥이 투명한 FMAT 플레이트 [어플라이드 바이오시스템즈 (Applied Biosystems, 영국)] 내에서 이중의 웰에 다음과 같이 첨가하였다:
a) 12.5 ㎕ dAb 단백질 또는 완충제 대조군. dAb 적정 출발 농도는 대개 10 μM (최종 농도)이었고, 이를 1:3.3 희석하여 (즉, 30 ㎕ 샘플을 0.1% BSA를 함유하는 PBS 70 ㎕에 첨가함) 8-지점 적정 효과 곡선을 생성하였다.
b) 0.1% BSA를 함유하는 PBS 내에 희석한, 0.2 ㎍/ml (0.05 ㎍/ml의 최종 농도에 대해)의 12.5 ㎕ CD40-Fc [브리스톨-마이어스 스퀴브, 미국에서 공급함; 로트 CY24Feb06-1].
c) 0.1% BSA를 함유하는 PBS 내에 희석한, 2 ㎍/ml (0.5 ㎍/ml의 최종 농도에 대해)의 마우스 항-인간 Fc [시그마-알드리치, 영국] 및 1 ㎍/ml (0.25 ㎍ ml의 최종 농도에 대해)의 염소 항-마우스 알렉사 플루어 (Alexa Fluor) 647 [인비트로젠, 영국]의 혼합물 12.5 ㎕.
d) 12.5 ㎕의 상기 설명된 IZ-CD40L 코팅된 비드를 웰의 가장자리로 분산하지 않도록 웰의 중심에 첨가하였다.
시약을 384 웰 플레이트에 첨가한 후에, 실온에서 6시간 동안 암소에서 인큐베이션한 다음, AB8200 FMAT 시스템 [어플라이드 바이오시스템즈, 영국]에서 판독하였다.
실시예 2
클론 BMS2h -572에 대한 dAb 선택
감소하는 농도의 항원을 사용하는 3 라운드의 선택 (라운드 1에서 300 nM; 라운드 2에서 30 nM; 라운드 3에서 3 nM)을 브리스톨-마이어스 스퀴브에서 제공한 비오티닐화된 (1.42 몰 비오틴/몰 삼량체) 인간 이소류신 지퍼-CD40L (IZ-hCD40L)에 대하여 평행으로 수행하였다. 나이브 4G 및 6G 도맨티스 dAb 라이브러리로부터의 파지를 선택을 개시하기 전에 아래 지시된 풀 a) 내지 h) 내로 합하였다:
a) 7 - 9 아미노산 사이의 4G VH CDR3 길이.
b) 10 - 12 아미노산 사이의 4G VH CDR3 길이.
c) 13 - 15 아미노산 사이의 4G VH CDR3 길이.
d) 4G VK.
e) 7 - 9 아미노산 사이의 6G VH CDR3 길이.
f) 10 - 12 아미노산 사이의 6G VH CDR3 길이.
g) 13 - 15 아미노산 사이의 6G VH CDR3 길이.
h) 6G VK.
각 라운드의 선택은 목적하는 농도의 비오티닐화된 CD40L을 2% MPBS (2% (w/v) 마벨을 함유하는 포스페이트 완충 염수 [프리미어 푸즈, 영국]) 1000 ㎕ 내의 파지 (상기 지시된 나이브 라이브러리 풀 중 하나로부터, 또는 후속적인 선택 아웃풋 파지)의 혼합물에 첨가하고, 회전시켜 혼합함으로써 실온에서 1시간 동안 인큐베이션하는 것을 포함하였다. 이어서, 비오티닐화된 항원 파지 복합체를 100 ㎕의 재현탁시킨 다이나비즈 M-280 스트렙타비딘 [인비트로젠, 영국] (라운드 1 및 3), 또는 뉴트라비딘 [써모 피셔 사이언티픽, 영국]과 커플링된 50 ㎕의 M-280 토실활성화된 다이나비즈 (인비트로젠)(라운드 2)을 첨가함으로써 포획하고, 실온에서 회전시켜 혼합하면서 5분 동안 인큐베이션하였다. 이어서, 다이나비즈를 킹피셔 자기 분리기 [써모 피셔 사이언티픽, 영국]를 사용하여 회수하고, 7 x 1 ml PBST (0.1% (v/v) 폴리옥시에틸렌소르비탄 20 모노라우레이트를 함유하는 PBS [시그마-알드리치, 영국])에 이어 1 x 1 ml PBS로 세척하였다. 세척한 다이나비즈 상에 보유된 결합된 파지를 500 ㎕의 트립신-PBS (450 ㎕ PBS에 첨가된 50 mM Tris-HCl pH 7.4, 1 mM CaCl2 내에 용해시킨 10 mg/ml 트립신 [시그마-알드리치, 영국] 50 ㎕)와 함께 인큐베이션함으로써 용리시켰다. 파지-함유 용액을 회수하고, 250 ㎕을 사용하여 37℃에서 30분 동안 1.75 ml의 대수 성장기 이. 콜라이 TG1 (0.4의 OD600에서)을 감염시켰다. 이. 콜라이 TG1 파지 감염된 배양액을 11,600 g에서 마이크로원심분리기 내에서 1분 동안 원심분리하고, 생성되는 세포 펠릿을 1 ml 2xTY (1 리터 내에 16 g 트립톤, 10 g 효모 추출물 및 5 g NaCl, 121℃에서 15분 동안 고압증기멸균시킴) 내에 재현탁시키고, 15 ㎍/ml 테트라사이클린을 보충한 TYE 배지를 담은 9 cm 페트리 디쉬 상에 플레이팅하였다. 플레이트를 37℃에서 밤새 인큐베이션한 후, 15% 글리세롤을 보충한 2xTY 2 ml을 각각의 플레이트에 첨가하고, 세포를 유리 스프레더로 느슨하게 하고 완전히 혼합하였다. 50 마이크로리터의 긁어낸 박테리아를 사용하여 15 ㎍/ml 테트라사이클린을 보충한 50 ml의 2xTY에 접종하고, 250 rpm으로 진탕하면서 37℃에서 밤새 성장시켰다. 밤샘 배양액을 3,300 g에서 15 min 동안 원심분리시켜 박테리아를 펠릿화하였다. 파지를 침전시키기 위해, 10 ml PEG/NaCl (20% 폴리에틸렌 글리콜 8000, 2.5 M NaCl)을 40 ml 상청액에 첨가하였다. 파지/PEG 용액을 혼합하고, 얼음 상에서 1 h 동안 방치한 후, 3,300 g에서 30 min 동안 4℃에서 원심분리하고, 상청액을 폐기하였다. 펠릿을 2 ml PBS 내에 재현탁시키고, 11,600 g에서 10 min 동안 마이크로원심분리기 내에서 원심분리하여 남아있는 박테리아 파편을 제거하였다. 이어서, 파지를 함유하는 생성되는 상청액을 적절한 농도의 비오티닐화된 IZ-hCD40L에 대하여 다음 선택 라운드를 위해 사용하였다.
파지 ELISA :
선택 라운드 2 및 3 후에 모노클로날 파지 ELISA를 수행하였다. 모든 세척은 250 ㎕ PBST의 3회 세척에 이어 250 ㎕ PBS의 3회 세척을 이용하여 수행하였다. 플레이트를 PBS 내의 1 ㎍/ml IZ-hCD40L 50 ㎕/웰로 4℃에서 밤새 코팅하였다. 플레이트를 세척한 후, 2% MPBS로 1시간 동안 실온에서 차단하였다. 플레이트를 세척하고, 25 ㎕/웰 파지 상청액을 동일 부피의 2% MPBS에 첨가하고, 1시간 동안 실온에서 인큐베이션하였다. 플레이트를 세척하고, 결합된 파지를 2% MPBS 내에 1:5000 희석한 항-M13-HRP 접합체 [지이 헬쓰케어, 영국] 50 ㎕/웰을 사용하여 검출하고, 1시간 동안 실온에서 인큐베이션하였다. 플레이트를 세척하고, ELISA를 50 ㎕/웰 슈어블루 1-성분 TMB 마이크로웰 페록시다제 용액 [케이피엘 인크., 미국]을 사용하여 발색시켰다. 동일 부피의 1 M HCl을 첨가하여 비색 반응을 중지시키고, ELISA 플레이트를 450 nm에서 판독하였다. 특이적 파지는 항원을 코팅하지 않지만 달리 동일하게 처리한 웰에 비교함으로써 확인하였다.
pDOM4 플라스미드로부터 dAb 유전자의 회수 :
라운드 2 및 3 아웃풋으로부터 dAb V-유전자를 파지 벡터 pDOM4의 SalI 및 NotI 제한 효소 소화에 의해 회수하고, SalI 및 NotI 이중 소화시킨 pDOM5 발현 벡터 내로 라이게이션하였다.
가용성 dAb ELISA :
결합 dAb는 다음과 같이 확인하였다. 가용성 dAb 발현 벡터 pDOM5 내로 클로닝된 dAb V-유전자를 함유하는 96개의 개별 콜로니를 각각의 아웃풋으로부터 OnEx 자가유도 배지를 함유하는 200 ㎕ 테리픽 브로쓰 [노바겐, 영국] 내로 집어넣고, 기체 투과성 접착 플라스틱 스트립으로 밀봉한 코스타 96 웰 세포 배양 클러스터 [코닝 인코포레이티드, 미국] 내에서 250 rpm에서 진탕하면서 37℃에서 밤새 인큐베이션하였다. 배양액을 원심분리하여 세포를 펠릿화하고, 상청액을 항원 결합 ELISA에 의해 IZ-hCD40L에 결합된 dAb에 대해 검정하였다. 맥시소프 96 웰 이뮤노플레이트 [눈크, 미국]를 4℃에서 PBS 중의 1 ㎍/ml IZ-hCD40L 50 ㎕/웰을 사용하여 밤새 코팅하였다. 모든 세척은 파지 ELISA에 대해 설명된 바와 같았다. 플레이트를 1시간 동안 실온에서 1% 트윈 20을 함유하는 PBS 200 ㎕로 차단하였다. ELISA 플레이트를 세척하고, dAb-함유 배양 상청액을 1,800 g에서 10 min 동안 4℃에서 원심분리하여 청정화한 후, 동일 부피의 PBST를 첨가한 ELISA 플레이트에 첨가하였다 (30 ㎕/웰). 플레이트를 1시간 동안 실온에서 인큐베이션한 후 세척하였다. 결합된 dAb는 PBST 내에 1:2000 희석한 9E10 [항-myc IgG, 시그마-알드리치, 영국] 50 ㎕/웰을 첨가하고 1시간 동안 실온에서 인큐베이션함으로써 검출하였고; 이어서, ELISA 플레이트를 세척하고, PBST 내에 1:2000 희석한 항-마우스 Fc-HRP [시그마-알드리치, 영국] 50 ㎕/웰을 첨가하고 1시간 동안 실온에서 인큐베이션하였다. 플레이트를 세척하고, ELISA를 50 ㎕/웰 슈어블루 1-성분 TMB 마이크로웰 페록시다제 용액 [케이피엘 인크., 미국]을 첨가함으로써 발색시키고, 색상을 발색시켰다. 동일 부피의 1 M HCl을 첨가하여 비색 반응을 중지시키고, ELISA 플레이트를 450 nm에서 판독하였다. 항원 결합 dAb는 IZ-hCD40L 웰로부터 신호 강도를 항원을 함유하지 않은 대조군 웰과 비교함으로써 확인하였다.
실시예 3
클론 BMS2h -503-1, BMS2h -719-2, 및 BMS2h -572-6의 확인
BMS2h-503, BMS2h-719 및 BMS2h-572 dAb를 오류 유발 친화도 성숙에 적용하여, 각각 BMS2h-503, BMS2h-719 및 BMS2h-572 계통을 생성하였다. 이것은 평균 3.6개 아미노산 변화가 dAb당 도입되는 무작위 돌연변이 유발을 사용하여 수행하였다. 파지 라이브러리 (평균 크기 6x108)는 항원의 교대 스트렙타비딘/뉴트라비딘 비드 포획 (설명된 바와 같이)을 이용하여 비오티닐화된 단량체 및 삼량체 인간 CD40L을 사용하여 선택하였다. 감소하는 농도의 항원 (라운드 1에 100 nM; 라운드 2에 10 nM; 라운드 3에 1 nM)을 사용하여 3 라운드의 선택을 수행하였다. 서열분석을 사용하여 각각의 선택 라운드 후의 다양성을 모니터링하였다. 선택 아웃풋 (BMS2h-572의 경우 CD40L 삼량체에 대해 선택된 라운드 2; BMS2h-503의 경우 CD40L 삼량체에 대해 선택된 라운드 3 및 BMS2h-719의 경우 CD40L 단량체에 대해 선택된 라운드 3)을 가용성 발현 벡터 pDOM13 (C 말단 태그 불포함) (설명된 바와 같이) 내로 서브클로닝하고, 단량체 및 삼량체 CD40L 둘 모두에 대한 모 클론에 비해 개선된 오프-레이트 (off-rate)에 대해 비아코어에 의해 모노클로날 박테리아 미량 배양 (micro-culture) 상청액으로서 스크리닝하였다. 확인된 개선된 변이체는 DNA 서열을 결정하고, 특유한 dAb를 발현시키고 정제한 후, BMS2h 비드 RBA 및 세포성 CD40L 유도 검정 (설명된 바와 같이)을 사용하여 검정하였다. 그 결과, BMS2h-503-1 (표 3에 나열된 서열), BMS2h-719-2 및 BMS2h-572-6 dAb (표 1에 나열된 서열)가 확인되었다. 이들 dAb의 활성을 아래 표 5에 나열한다.
Fc 융합체로서 BMS2h -503-1, BMS2h -719-2 및 BMS2h -572- 6의 포맷
BMS2h-572-6, BMS2h-503-1 및 BMS2h-719-2 dAb를 인간 IgG1로부터 유래된 Fc 테일을 함유하는 pDOM38 벡터 내로 클로닝하여, 각각 DMS0502, DMS0500 및 DMS0501을 생성하였다. 또한, BMS2h-572-6, BMS2h-503-1 및 BMS2h-719-2 dAb를 인간 IgG4로부터 유래된 Fc 테일을 함유하는 pDOM38 벡터 내로 클로닝하여, 각각 DMS0505, DMS0506 및 DMS0504를 생성하였다. 구축물을 HEK293 세포에서 일시 발현시키고, 단백질 A를 사용하여 단백질을 정제하였다. 정제된 Fc 융합체는 단량체 및 삼량체 CD40L에 대한 결합에 대해 비아코어에 의해 및 다양한 세포 검정 (설명된 바와 같이)으로 분석하였다.
클론 BMS2h -572-608, BMS2h -572-614 및 BMS2h -572-619의 확인
BMS2h-572-6 dAb를 도핑된 (doped) 올리고 방법을 사용하여 친화도 성숙에 적용하였다. 4개의 도핑된 라이브러리를 상기 dAb에 대해 구축하였다:
라이브러리 1 - CDR1 내의 5개 잔기 다양화됨
라이브러리 2 - CDR2 내의 6개 잔기 다양화됨
라이브러리 3 - CDR2 내의 13개 잔기 다양화됨
라이브러리 4 - CDR3 내의 7개 잔기 다양화됨
각각의 라이브러리에서, 다양화는 nnS 코돈을 사용하여 수행하였고, 여기서 n은 큰 비율의 모 염기 (85%)를 유지하고, 나머지는 등몰량의 나머지 3개의 염기 (각각 5%)로 분리하고, S는 G 또는 C이었다. 파지 라이브러리 (평균 크기 8x108)는 항원의 교대 스트렙타비딘/뉴트라비딘 비드 포획 (설명된 바와 같이)을 이용하여 비오티닐화된 단량체 및 삼량체 인간 CD40L을 사용하여 선택하였다. 라이브러리 2 및 3을 선택 공정 동안 취합하였다. 감소하는 농도의 항원 (라운드 1에 50 nM; 라운드 2에 5 nM; 라운드 3에 1 nM (200배 과량의 경쟁자 - 비-비오티닐화된 CD40L 삼량체 사용))을 사용하여 3 라운드의 선택을 수행하였다. 서열분석을 사용하여 각각의 선택 라운드 후의 다양성을 모니터링하였다. 선택 아웃풋 (라운드 2 및 3)을 가용성 발현 벡터 pDOM13 (C 말단 태그 불포함) (설명된 바와 같이) 내로 서브클로닝하고, 단량체 및 삼량체 CD40L 둘 모두에 대한 모 클론에 비해 개선된 오프-레이트에 대해 비아코어에 의해 모노클로날 박테리아 미량 배양 상청액으로서 스크리닝하였다. 확인된 개선된 변이체는 DNA 서열을 결정하고, 특유한 dAb를 발현시키고 정제한 후, BMS2h 비드 RBA 및 세포성 CD40L 유도 검정 (설명된 바와 같이)을 사용하여 검정하였다. 그 결과, BMS2h-572-608, BMS2h-572-614 및 BMS2h-572-619 dAb가 확인되었다.
클론 BMS2h -572-633의 구축
서열 분석은 BMS2h-572-608과 모 dAb BMS2h-572-6 사이의 모든 아미노산 차이가 CDR1에 위치하고, BMS2h-572-614와 모 dAb BMS2h-572-6 사이의 차이는 CDR3에 위치함을 보여주었다. 두 성숙 dAb는 CDR2를 모 dAb BMS2h-572-6과 공유하였다. 이것은 BMS2h-572-608의 CDR1 및 BMS2h-572-614의 CDR3을 갖는 조합 돌연변이체를 구축할 기회를 제시하였다. 먼저, BMS2h-572-608의 CDR1 영역을 PCR 증폭하였다. 두 번째로, BMS2h-572-614의 CDR2+CDR3 단편을 PCR 증폭하였다. 이어서, 2개의 단편에 대해 SOE PCR 회합을 수행하여 조합 돌연변이체 BMS2h-572-633을 생성하였다. 회합된 dAb PCR 생성물을 가용성 발현 벡터 pDOM13 (C 말단 태그 불포함) 내에 클로닝하고, 서열을 확인하고, 발현시키고, 정제한 후, BMS2h 비드 RBA 및 세포성 CD40L 유도 검정 (설명된 바와 같이)을 사용하여 검정하였다.
Fc 융합체로서 BMS2h -572-633의 포맷
BMS2h-572-633 dAb를 인간 IgG1로부터 유래된 Fc 테일을 함유하는 pDOM38 벡터 내로 클로닝하여 DMS0507을 생성하였다. 구축물을 HEK293 세포에서 일시 발현시키고, 단백질 A를 사용하여 단백질을 정제하였다. 정제된 Fc 융합체는 단량체 및 삼량체 CD40L에 대한 결합에 대해 비아코어에 의해 및 다양한 세포 검정 (설명된 바와 같이)으로 분석하였다.
실시예 4
CD40L 활성 세포 검정
항-인간 CD40L dAb를 CD40L 활성을 길항하는 능력에 대해 기능적으로 검정하였다. 시험된 CD40L 활성은 일차 단핵구-유래 수지상 세포 (DC)의 hCD40L-유도 활성화에 의한 B 세포 증식 및 시토카인 생산이었다. 달리 주지하지 않으면, 모든 검정을 10% 태송아지 혈청 (FCS)을 보충한 RPMI 내에서 수행하였다. 아래에서 상세히 설명되는 다양한 검정의 결과를 표 5 및 표 6에 제시한다.
가용성 IZ - hCD40L-유도 일차 인간 B 세포 증식:
1x105 편도선 인간 B 세포를 96-웰 환저 플레이트에서 200 ㎕/웰의 최종 부피로 dAb 또는 mAb의 상이한 적정을 수행하면서 0.6 ㎍/ml의 IZ-hCD40L과 함께 인큐베이션하였다. 플레이트를 티미딘 (3H; 0.5 μci/웰)을 6시간 동안 첨가한 후 37℃에서 72시간 동안 인큐베이션하였다. B 세포 증식은 티미딘 도입을 기초로 하여 정량하였다. 모든 검정은 달리 주지하지 않으면 10% 태송아지 혈청 (FCS)을 보충한 RPMI 배지 내에서 수행하였다.
CHO - hCD40L -유도 일차 인간 B 세포 증식:
CHO 세포를 세포 표면 상에 높은 수준의 CD40L을 발현하는 안정한 세포주를 생성하기 위해 인간 CD40L로 형질감염시켰다. CHO-CD40L 세포에 10,000 Rad에서 방사선을 조사한 후, 인간 B 세포와 함께 인큐베이션하였다. 1x105 편도선 인간 B 세포를 96-웰 환저 플레이트에서 200 ㎕/웰의 최종 부피로 dAb 또는 mAb의 상이한 적정을 수행하면서 1x103 CHO-CD40L 세포 (1:100 비의 CHO-CD40L: 인간 B 세포)와 함께 인큐베이션하였다. 플레이트를 티미딘 (3H; 0.5 μci/웰)을 6시간 동안 첨가한 후 37℃에서 72시간 동안 인큐베이션하였다. B 세포 증식은 티미딘 도입을 기초로 하여 정량하였다. 모든 검정은 달리 주지하지 않으면 10% 태송아지 혈청 (FCS)을 보충한 RPMI 배지 내에서 수행하였다.
일차 T 세포-유도 인간 B 세포 증식:
T 세포를 인간 말초 혈액 단핵 세포 (PBMC)로부터 단리하고, 양 적혈구 (SRBC) 친화도를 통해 농축하였다. 농축된 인간 T 세포를 PM-LCL (EBV-형질전환된 B 세포주; 10,000 Rad에서 방사선 조사됨)와 함께 5:1 비 (T:LCL)로 6일 동안 37℃에서 배양하여 동종이형 T 세포의 집단을 생성하였다. 제6일에, 확장된 T 세포를 단리하고, 3000 Rad에서 방사선 조사한 후, 항-CD3 mAb (OKT3)로 코팅된 96-웰 평저 플레이트에서 일차 인간 편도선 B 세포 (1x105 B 세포/웰)와 함께 1:2의 비로 배양하였다 (5x104 T 세포/웰). dAb/mAb의 상이한 적정액을 각각의 웰에 첨가하였고; 각각의 웰 내의 최종 부피는 200 ㎕이었다. 시험 플레이트를 37℃에서 3일 동안 인큐베이션하였다. 인간 B 세포 증식은 마지막 18시간 동안 배양액에 티미딘 (3H; 0.5 μci/웰)을 첨가함으로써 결정하였다. 모든 검정은 달리 주지하지 않으면 10% 태송아지 혈청 (FCS)를 보충한 RPMI 내에서 수행하였다. 몇몇 예에서, 상청액을 수거하고, IL-6의 존재에 대해 측정하였다.
일차 인간 단핵구-유래 수지상 세포 ( DC )의 CHO - hCD40L -유도 활성화:
인간 PBMC를 SRBC 재조정 (resetting)을 통해 T 세포를 고갈시킴으로써 단핵구에 대해 농축하였다. 단핵구-농축된 PBMC를 10 ng/ml GM-CSF 및 5 ng/ml IL-4와 함께 6-웰 플레이트에서 6일 동안 37℃에서 배양하였다. 배양된 플레이트에 제2 및 5일에 신선한 배지 (GM-CSF 및 IL-4 함유)를 보충하였다. 미성숙 DC를 제6일에 세포 검정에 사용하였다. 8x104 미성숙 DC를 96-웰 평저 플레이트에서 dAb/mAb의 상이한 적정을 수행하면서 4x103 CHO-hCD40L 세포 (10,000 Rad에서 방사선 조사됨)와 함께 배양하였다. 24시간 후에, 상청액을 수거하고, 다양한 시토카인 (IL-12, TNF, IL-23)의 존재에 대해 시험하였다. DC 활성화는 시토카인 생산 수준에 의해 결정하였다. 모든 검정은 달리 주지하지 않으면 10% 태송아지 혈청 (FCS)을 보충한 RPMI 배지 내에서 수행하였다.
Figure pct00145
Figure pct00146
Figure pct00147
Figure pct00148
Figure pct00149
Figure pct00150
Figure pct00151
Figure pct00152
Figure pct00153
실시예 5
다양한 항체의 결합 동역학 및 CD40L 친화도
BMS-986004는 dAb BMS2h-572-633의 C-말단에 연결된 IgG1의 변형된 Fc 단편으로 이루어진 이량체 융합 단백질이다. 표면 플라즈몬 공명 (SPR)을 사용하여 CD40L에 결합하는 BMS-986004 또는 1가 성분 도메인 항체 BMS2h-572-633의 동역학 및 친화도의 특성을 결정하였다. BMS-986004 값을 기준 (benchmark) 항체 5c8-IgG1 및 5c8-CT 및 1가 성분 5c8 FAB 단편에 대한 것과 비교하였다. SPR 실험은 CD40L 분자의 천연 삼량체 형태로의 특이적인 회합을 용이하게 하는 N-말단 이소류신 지퍼 모티프 (IZ-hCD40L)를 함유하는 hCD40L 구축물을 이용하였다. 동등한 결합 활성을 갖는 IZ-hCD40L의 비오티닐화된 버전 (biot-IZ-hCD40L)도 몇몇 SPR 실험을 위해 이용되었다.
1가 BMS2h-572-633 도메인 항체는 1가 5c8 FAB 단편에 대한 5.4 nM의 친화도에 비해 7.8 nM의 Kd로 biot-IZ-hCD40L에 결합한다 (표 7). BMS-986004는 2가이고 IZ-hCD40L 표적은 삼가이기 때문에, SPR 결합 데이터는 CD40L 표적이 칩 표면 상에 또는 용액 내에 존재하는지와 무관하게 결합력에 의해 영향받는다. 결합력에 의해 영향받은 결합 친화도를 평가하기 위해서, biot-IZ-hCD40L 표면에 대한 BMS-986004 결합의 SPR 데이터를 1:1 랭뮤어 모델에 피팅하였고, 이것은 해리 상수가 1 nM 미만임을 시사하였다 (표 7). 유사한 결과가 5c8-IgG1 및 5c8-CT에 대해 얻어졌다.
Figure pct00154
도 5는 25℃에서 스트렙타비딘 SPR 센서 칩에 포획된 biot-IZ-hCD40L에 대한 12.5-0.39 nM BMS-986004 (2:1 희석 계열)의 결합에 대한 SPR 센서그램 데이터를 도시한 것이다. 유색 선은 이중 참조 센서그램 데이터를 보여주고, 흑색 선은 데이터에 피팅된 1:1 랭뮤어를 보여주고, 여기서 결합력-영향받은 겉보기 Kd 값은 0.11 nM이다.
또한, CD40L에 대한 BMS-986004 결합의 친화도 및 열역학은 15-37℃의 온도에서 등온 적정 열량 측정 (ITC)을 사용하여 용액에서 특성화하였다. 이들 데이터는 SPR 데이터와 일치하게, 상이한 방식에 대한 Kd 값이 고-친화도 검출 한계 (Kd <2 nM)를 넘어서는 (표 8) 열역학상 구분되는 여러 결합 방식의 존재를 시사하였다 (도 6). 또한, ITC (3.5 nM)에 의해 결정할 때 IZ-hCD40L에 대한 1가 5c8 FAB 단편의 친화도는 SPR에 의해 결정된 값과 일치하였다.
Figure pct00155
실시예 5
다양한 항체의 Fc 수용체 친화도
BMS-986004 ("CT"로 언급됨)의 Fc-도메인을 FcRn에 결합하지만 Fcγ 수용체에 대한 결합을 붕괴시키는 능력을 보유하도록 야생형 IgG1 Fc 도메인로부터 조작하였다. 조작된 분자가 목적하는 Fc 수용체 결합 프로파일을 갖는지 확인하기 위해서, 인간 FcRn, 및 인간 Fcγ 수용체 CD64 (FcγRI), CD32a (FcγRIIa), CD32b/c (FcγRIIb/c), CD16a (FcγRIIIa), CD16b (FcγRIIIb)에 대한 BMS-986004의 결합 친화도는 5c8-IgG1 및 5c8-CT에 비교하여, SPR을 사용하여 측정하였다. 이들 실험을 위해, BMS-986004를 biot-IZ-hCD40L 센서 표면 상의 도메인 항체 도메인을 통해 포획하고, 가용성 Fc 수용체 단백질을 노출된 Fc 도메인에 대한 결합에 대해 시험하였다. 이와 유사하게, 5c8-IgG1 및 5c8-CT를 가용성 FcR 결합을 사용하여 FAB 도메인을 통해 biot-IZ-hCD40L 표면 상에 포획하였다.
BMS-986004는 엔도솜 내 결합을 위한 관련 pH인 pH 6.0에서 670 nM의 Kd로 FcRn에 결합하였다 (표 9). 그러나, 결합은 중성 pH에서 유의하게 감소하였고 (Kd >5000 nM), 이것은 상기 조건 하에서 FcRn로부터 효율적인 방출을 시사한다. BMS-986004는 CD64에 0.6 nM의 Kd로 결합하였고, CD32a, CD32b/c, CD16a 및 CD16b에 대해 통계적으로 약한 친화도를 가졌다 (Kd >3000 nM). 5c8-IgG1 및 5c8-CT 둘 모두는 BMS-986004와 유사한 FcRn 친화도를 가졌다. 또한, BMS-986004와 동일한 "CT" Fc 영역을 갖는 5c8-CT는 BMS-986004와 유사한 FcγR 결합 특성을 갖는 반면에, 야생형 IgG1 Fc 도메인을 갖는 5c8-IgG1은 FcγR에 보다 강하게 결합하였다 (표 9).
Figure pct00156
실시예 6
시험관내 세포-기반 분석
BMS-986004의 효능을 상이한 세포 종류에 걸쳐 강력한 효능을 보장하기 위해 다양한 일차 면역 세포 검정에서 평가하였다. 일차 인간 B 세포 증식 검정을 상기 실시예 4에 상세히 설명된 바와 같이 2가지 방식으로 수행하였다: (1) 재조합 CD40L 삼량체를 B 세포 증식을 유도하기 위해 사용하였고; (2) 막 상에 CD40L을 발현하는 CHO 세포 (CHO-CD40L)를 B 세포 증식을 유도하기 위해 이용하였다. CHO-CD40L 세포의 유용성은 막-결합형 CD40L로부터의 신호가 가용성 CD40L 삼량체에 비해 동등하게 잘 억제됨을 보장하기 위해 특히 중요하였다. 또한, CHO-CD40L 세포는 GM-CSF 및 IL-4의 존재 하의 PBMC-유래 단핵구의 배양으로부터 분화된 일차 인간 DC의 활성화를 유도하기 위해 사용되었다. 이와 유사하게, T-B MLR 검정은 활성화된 T 세포에 존재하는 CD40L에 의해 유도된 B 세포 활성화를 측정하였다. 모든 상기 설명한 일차 검정에서, BMS-986004는 기준 5c8 mAb과 효능이 동등하였고: 효능 범위는 검정에 따라 한자리 수 nM로부터 sub-nM이었다 (표 10).
Figure pct00157
실시예 7
전혈 수용체 점유 ( RO )의 평가
시노몰구스 원숭이 전혈 샘플에서 BMS-986003, 및 후속적으로 인간 전혈 샘플에서 BMS-986004에 의한 CD40L 표적 접촉을 측정하기 위해 수용체 점유 방법을 개발하였다. BMS-986003은 그의 아미노-말단에서의 비-천연 글리신 잔기를 제외하고 BMS-986004와 동일한 아미노산 서열을 공유하는 dAb이다.
점유는 CD40L에 대한 결합에 대해 BMS-986003/BMS-986004와 경쟁하고 인간 및 시노몰구스 원숭이 CD40L과 교차-반응성인 항-CD40L mAb를 사용하여 유동 세포측정법에 의해 CD4+ T 세포 상에서 측정한다. 결합된 dAb의 존재 하에, 항-CD40L 검출 mAb는 농도-의존 방식으로 CD40L에 대한 결합으로부터 차단되고, 표적 점유의 척도를 제공한다. 기저 CD40L이 말초 혈액 내의 휴지 T 세포 상에서 낮은 수준으로 발현되는 것을 고려하여, 비자극된 혈액 샘플 및 피토헤마글루티틴 (PHA)이 T 세포 표면 상의 CD40L의 상향조절을 유도하기 위해 사용되는 샘플 둘 모두에서 RO를 평가하였다. BMS-986003 및 BMS-986004를 사용한 생체 외 전혈 처리 후에 결합 효능 곡선을 생성하였다. 얻어진 평균 EC50 및 EC90 값을 표 11에 제시한다.
Figure pct00158
BMS-986003 및 BMS-986004에 대한 전혈 내의 표적 결합 효능은 인간과 시노몰구스 원숭이 사이에서 밀접하게 상호관련된다. BMS-986003 및 BMS-986004에 대한 EC50 값은 또한 기저 및 PHA-유도된 CD40L에 결합할 때도 유사하였다. 추가로, 이들 값은 인간 시험관 내 세포 기반 검정에서 얻은 것과 대등하다 (표 10 참조). 측정된 EC90 값을 기초로 하여, 말초 혈액에서 완전한 표적 포화는 농도 ≤10 nM에서 달성될 것이다.
BMS-986003 및 BMS-986004의 전임상 PK/PD 프로파일을 지지하기 위해, RO를 BMS-986003을 사용한 시노몰구스 원숭이 KLH 연구 (키홀 림펫 헤모시아닌을 사용한 면역화) 및 BMS-986004를 사용한 IV 가교 연구 둘 모두에서 평가하였다. 이들 발견에 대한 추가의 상세한 내용은 아래 실시예에서 볼 수 있다.
실시예 8
생체내 약물학
마우스 질환 모델에서 CD40L dAb의 효능을 보여주기 위해, 마우스 CD40L dAb 2m126-24를 Fc 이펙터 기능을 추가로 저하시키기 위해 D265A 점 돌연변이를 갖는 마우스 IgG1 Fc로 포맷하였다. 상기 마우스 대용물 dAb 2m126-24-Fc는 BMS-986004 및 MR-1 (햄스터 항-마우스 CD40L 항체)과 대등한 효능을 보여준다 (표 12).
Figure pct00159
마우스 CD40L dAb 에 의한 KLH 유도된 항체 반응의 억제
암컷 BALB/c 마우스에게 제0일에 250 ㎍ KLH를 복강내 (i.p.) 주사하였다. 마우스에게 MR-1 또는 BMS-2m-126-24-Fc를 지시된 용량으로 제-1일 및 제6일에 피하 (s.c.) 투여하였다. 혈액을 수집하고, 혈청을 ELISA에 의해 제7일에 항-KLH IgM에 대해 및 제14일에 IgG에 대해 분석하였다. KLH를 사용한 면역화 후 제14일에 수집한 BALB/c 마우스로부터 혈청을 모으고, 양성 비교체로서 사용하고, 데이터를 시험 혈청의 역가 대 모아진 BALB/c 혈청의 역가의 비로서 표현한다. 도 7에 제시된 바와 같이, BMS-2m-126-24-Fc는 IgG 역가의 용량 의존적 억제를 보였고, 최대 효과는 3 mg/kg에서 나타났고, ED50은 0.26 mg/kg으로 계산되었다. CD40L dAb 및 항체 둘 모두는 1 mg/kg으로 시험되었고, 각각 IgG 반응의 70% 대 30% 감소를 보였다. dAb 및 항체의 유사한 노출은 1 mg/kg에서 관찰되었고, 이것은 dAb가 KLH-유도된 IgG 반응의 억제시에 항체보다 약간 더 효능이 있음을 제시한다. 결론적으로, CD40L dAb는 T 세포 의존성 항체 반응의 억제시에 항-CD40L 항체와 적어도 동일한 수준의 효능을 보였다.
마우스 CD40L dAb 에 의한 TNBS -유도 결장염의 억제
수컷 SJL/J 마우스에게 항문에서 4 cm 멀리 삽입한 카테터를 통해 50% EtOH 중의 2.5 mg 트리니트로벤젠 술폰산 (TNBS)을 직장내 투여하였다. 마우스에게 TNBS 주사 4시간 전에 MR-1 또는 BMS-2m-126-24-Fc를 지시된 용량으로 1회 s.c. 투여하였다. 도 8은 PBS/IgG 또는 다양한 용량 수준의 MR-1 또는 dAb로 처리한 마우스의 군의 평균 체중 및 % 생존의 변화를 제시한다. 아바타셉트를 양성 대조군으로서 사용하였다 (20 mg/kg, i.p. 격일). TNBS-유도된 결장염의 대표적인 프로파일을 IgG 대조군에 제시하였고: 체중 감소는 제3-4일에 최고치이고; 결장염-관련 사망은 제3일 및 그 이후에 발생하고, 생존한 마우스는 제4일 후에 회복의 징후를 보였다. CD40L dAb 또는 항체 (둘 모두 2, 8 및 20 mg/kg로 처리함)를 사용한 처리는 체중 감소의 용량-의존적 억제 및 생존률의 증가를 일으켰고; 두 화합물은 모두 8 mg/kg에서 20 mg/kg의 아바타셉트에 대등한 효능을 생성시켰다. 결론적으로, 마우스 CD40L dAb BMS-2m-126-24-Fc는 급성 TNBS-유도된 결장염 모델에서 항-CD40L 항체 MR-1에 대등한 효능을 나타냈다.
마우스 "심장-대-귀" 이식 모델에서 CTLA4 Ig 및 마우스 CD40L dAb 사이의 상승작용적 효과
신생 (48-72 hr) C57Bl/6 마우스로부터 심장 이식편을 BALB/c 마우스의 귓바퀴에 생성된 피하 주머니에 이식하였다. 마우스를 CTLA4-Ig (i.p. 2x/wk), BMS-2m126-24-Fc (s.c. 1x/wk), 또는 둘의 조합물을 지시된 용량으로 처리하였고, 여기서 1회 투여는 이식 전날에 개시하였다. 거부까지 시간은 동종이식편의 심전도 (ECG) 장치에 의해 매일 측정할 때 연속 3일 동안 심장 수축력의 부재로 정의하였다. 예상된 바와 같이, 임의로 처리하지 않으면, 신생 BALB/c 심장을 받은 C57BL/6 마우스는 직후에 이식편을 거부하였고, 여기서 중간 생존 시간 (MST)은 12일이었다. 3, 20 mg/kg의 dAb 또는 25 mg/kg의 CTLA4-Ig를 사용한 단독요법은 동종이식편의 생존을 연장하는데 효과가 거의 또는 전혀 없었다 (MST: 각각 12, 15 및 13일). 그러나, 20 mg/kg의 dAb 및 25 mg/kg의 CTLA4-Ig의 조합물을 사용하여 처리한 군에서, 이식편 생존은 유의하게 연장하였고, 35일의 MST을 보여주었다 (도 9). 상기 데이터는 인간 신장 이식 환자에서 CD40L dAb를 벨라타셉트와 조합하는 근거를 제공하였다. 비-인간 영장류에서 미래의 이식 연구에서는 용량 수준을 추가로 규정하고 CD40L dAb BMS-986004를 사용한 관용 유도에 대한 잠재적인 효과를 평가할 것이다.
실시예 9
생체내 비임상 약동학 ( PK ) 및 약역학 ( PD )
비임상 환경에서 BMS-986004, BMS-986003, 및 마우스 CD40L dAb-Fc 대용물 BMS-2m-126-24-CT의 PK 및 PD를 특성화하기 위해 다양한 생체내 연구를 수행하였다. 중요 발견을 아래에 요약한다.
BMS -986004 dAb 를 측정하기 위한 ELISA
효소-연결 면역흡착 검정 (ELISA)-기반 생물분석 방법을 마우스에서 PK 연구, 급성 및 만성 효능 연구, 및 시노몰구스 원숭이를 사용하는 탐구적 PK/PD 연구를 지지하기 위해 개발하였다. 모든 경우에, 전혈을 얻고, EDTA의 존재 하에 혈장을 제조한 후, 샘플을 ELISA 분석하였다.
BMS-986004의 혈장 농도를 시험 샘플로부터 분석물을 포획하기 위해 인간 CD40L 항원을 사용한 ELISA 검정으로 측정하였다. 시험 샘플을 4℃에서 해동시키고, 잘 혼합하고, 1x PBS, 0.05% 트윈-20, 및 1% BSA (PTB)로 이루어진 검정 희석제 내에 1:100 희석하였다. 샘플의 후속 희석액은 희석제로서 1% 정상 원숭이 혈장/PTB를 사용하여 제조하였다. 이것은 샘플 매트릭스를 1%로 유지하면서 시험 분석물이 몇몇 희석률 (102 - 105)에서 검정되도록 허용하였다.
재조합 삼량체 인간 CD40L을 PSS (Protein Structure and Science, LVL)로부터 입수하고, 96 웰 플레이트에 2 ㎍/mL의 최종 농도로 결합시켰다. 시험 샘플, 품질 대조군 (QC) 샘플 및 표준물을 0.25 ㎍/ml의 농도로 PTB 내에 희석시킨 친화도-정제된 토끼 항-중쇄 (Vh) 도메인 프레임워크 폴리클로날 항체 (코번스 리써치 프로덕츠 (Covance Research Products, 미국 펜실베니아주 덴버))에 이어서 기질 (TMB - 테트라메틸벤지딘)을 첨가한 양고추냉이 퍼옥시다제-표지된 당나귀 항-토끼 폴리클로날 이차 항체 (잭슨 이뮤노리서치 (Jackson Immunoresearch, 미국 펜실베니아주 웨스트 그로브))를 사용하고, 1 M 인산으로 효소 반응을 중지시켜 검출하였다. 450 nm의 파장에서 흡광도를 측정하였다. 시험 샘플 내에 BMS-986004의 분석을 표준 곡선을 이용하여 수행하였다. 1% 원숭이 혈장 내에서 각각의 실행일에 작성한 표준 곡선 교정기를 이용하여 생물분석 방법의 역학 범위를 규정하였다. 100% 혈장 내에서 생성되는 표준 곡선의 범위는 10 - 1200 ng/mL이었다. BMS-986004에 대한 참조 표준물을 BPPD (Biologics Process and Product Development, HPW)로부터 입수하였다. 참조 표준 물질은 제조 배치 (batch)를 대표하고, 연구 프로토콜에서 사용되었다. 표준 곡선 및 QC는 검정 수행을 위해 허용가능한 것으로 간주되는 ≤20%의 정확도 및 정밀도의 기준을 이용하여 평가하였다. 시험 샘플을 교정기로부터 유래한 역농도 (1/x)에 의해 가중된 4-파라미터 로지스틱 피트 회귀 모델을 이용하여 정량하였다.
그의 공칭 값으로부터 계산된 농도의 편차에 의해 측정한 QC 샘플의 성능은 참조 물질이 2개월 초과 동안 -70℃에서 저장할 때 순수 원숭이 혈장 내에서 30 - 1000 ng/ml의 농도에서 안정함을 지시하였다.
마우스 대용물 dAb 를 측정하기 위한 ELISA
몇몇 급성 및 만성 효능 연구 및 PK 평가의 지지에서 노출 데이터를 제공하기 위해 마우스 CD40L-특이적 dAb BMS-2m-126-24-CT를 마우스 혈장 샘플 내에서 측정하였다.
마우스 dAb에 대한 검정 형식은 원숭이 샘플 내의 인간 dAb에 대한 것과 꽤 유사하지만 몇 가지 차이가 있다. 마우스 혈장 매트릭스는 검정 희석제 내에 1:10 (10%) 희석시키고, 시험 샘플의 모든 후속 희석액은 10% 마우스 매트릭스를 사용하여 제조하였다. 이와 마찬가지로, 모든 표준물 및 QC는 또한 10% 마우스 혈장 내에서 ELISA 플레이트 상에서 인큐베이션하였다. 마우스로부터 시험 샘플 내의 BMS-2m-126-24-CT의 농도는 분석물을 포획하기 위해 마우스 CD40L을 이용하여 측정하였다. 마우스 dAb는 Vk 프레임워크를 가지므로, 모든 시험 샘플, QC, 및 표준물은 PTB 내에 0.5 ㎍/mL의 농도로 희석시킨 친화도 정제된 토끼 항-카파 (Vk) 도메인 폴리클로날 항체 (코번스 리써치 프로덕츠, 미국 펜실베니아주 덴버)를 사용하여 검출하였다. 나머지 검정 및 분석 절차는 인간 CD40L dAb의 분석을 위한 절차와 유사하였다. 표준물 및 QC에 대한 역-계산된 농도에 대한 허용 기준은 또한 인간 CD40L dAb에 대한 것과 유사하였다. 표준 곡선으로부터 결정할 때 BMS-2m-126-24-CT의 정량 범위는 순수 샘플 매트릭스 내에서 12.5 내지 600 ng/mL이었다.
비임상 약동학
표 13은 비임상 동물 종에서 BMS-986004, BMS-986003, 및 BMS-2m-126-24-CT에 대한 PK 파라미터를 요약한다.
Figure pct00160
BMS-986004 및 BMS-986003는 원숭이에서 대등한 PK 프로파일을 나타냈다 (도 11a 및 도 11b). IV 투여 후에, BMS-986004 및 BMS-986003의 혈장 농도는 각각 504 및 408 h까지 이중-지수 감소를 보였다. 그 후 두 연구에 참여시킨 원숭이의 50%에서 가속된 클리어런스 (clearance)가 관찰되었다. BMS-986004 처리 38 d 후에 수집한 혈장 샘플의 면역원성 시험은 모든 원숭이가 항-약물 항체 (ADA)를 생성하였고; 더 높은 ADA 수준을 갖는 원숭이가 더 빠른 클리어런스를 보임을 제안하였다. BMS-986003을 사용한 IV PK 연구에 대해 면역원성 시험을 수행하지 않았지만, PK/PD 연구에서 BMS-986003의 피하 투여 후 원숭이에서 유사한 수준의 면역원성이 관찰되었고, 이것은 두 단백질 모두 원숭이에서 면역원성임을 제안한다. 따라서, 2주 (336 h)까지만 수집한 노출을 이용하여 BMS-986004 및 BMS-986003에 대한 124 및 106 h의 말기 반감기 (T1/2)가 결정되었다. BMS-986004 및 BMS-986003의 항정 상태 분포 용적 (Vss)은 각각 0.098 및 0.074 L/kg이었다. 이 값은 혈장 부피 (0.06 L/kg)보다 크지만, 세포외액의 부피 (0.2 L/kg)보다 적었고, 이것은 단백질이 주로 세포외 공간에 체류함을 제안한다. BMS-986004 및 BMS-986003의 총 체내 혈장 클리어런스 (CLTp)은 각각 0.59 및 0.65 mL/h/kg이었다.
원숭이에서 BMS-986004의 PK 파라미터를 동일한 변형된 인간 IgG1 Fc 형식을 갖는 유사한 크기 단백질인 아바타셉트 (아미노산 서열에 기반하여 78.5 대 78-kDa BMS-986004)에 비교하였다. 예상된 바와 같이, BMS-986004의 파라미터는 아바타셉트와 거의 동일하였고 (0.6 mL/h/kg의 CLTp, 0.087 L/kg의 Vss, 5 d의 T1/2), 이것은 BMS-986004 및 아바타셉트의 인간 PK가 유사할 것임을 제안한다.
피하 (SC) 투여 후 BMS-986003의 흡수를 원숭이 PK/PD 연구에서 평가하였다. 원숭이에게 BMS-986003을 0 (비히클 대조군), 0.2, 2 및 20 mg/kg로 단일 피하 용량으로 투여하고, 24 h 후에 키홀 림펫 헤모시아닌 (KLH, T 세포-의존성 항원)으로 면역화시켰다. 투여 후에, BMS-986003은 서서히 흡수되고, 여기서 Tmax는 6-96 h이었다 (도 12). BMS-986003의 노출은 모든 용량 수준에 걸쳐 용량-비율보다 더 적은 것으로 보였다. 1:10:100의 용량 비에서, 평균 Cmax 및 AUC0-inf 비는 각각 1:12:80 및 1:7:44이었다. 참조로서 IV 용량 (2 mg/kg) 후 노출에서 IV 투여 후 선형 PK을 가정할 때, BMS-986003의 SC 생체이용률은 0.2, 2, 및 20 mg/kg에서 각각 88%, 74%, 및 44%이었다. 말기 T1/2는 투여 2 내지 5주 후에 대부분의 원숭이에서 관찰된 면역원성에 의해 혼동되었다. 따라서, T1/2은 0.2, 2 및 20 mg/kg에서 각각 85, 66, 및 105 h인 것으로 추정되었다.
5c8-IgG1 (PK/PD 연구에서 양성 대조군으로서 사용된 항-인간 CD40L 모노클로날 항체)의 PK를 20 mg/kg의 IV 투여 후에 평가하였다 (도 12). 5c8-IgG1은 동일한 용량으로 SC 투여된 BMS-986003에 비해 10배 더 높은 혈장 노출 및 4배 더 긴 T1/2을 보였다 (표 13).
마우스 대용물 dAb-Fc 융합 단백질 (BMS-2m-126-24-CT)의 PK를 단일 IV 및 SC 투여 후에 마우스에서 평가하였다 (표 13). 단일 IV (1 mg/kg) 후에, 혈장 농도는 단일-지수 감소를 따랐고, 여기서 말기 T1/2은 101 h이었다 (도 13). CLTp는 1.85mL/h/kg이고; Vss는 0.26L/kg이었고, 이것은 세포외 분포를 지시하였다. 1 및 10 mg/kg의 단일 SC 용량 후에, BMS-2m-126-24-CT는 24 h의 Tmax를 가지면서 서서히 흡수되었다. 전신 노출은 용량-비례 방식으로 증가하였다. 1:10의 용량 비에서, Cmax 및 AUC0-inf는 1:11의 비율로 증가하였다. 말기 T1/2은 1 및 10 mg/kg에서 각각 100 및 120 h이었다. SC 및 IV 투여 후에 용량-조정된 노출의 비 (AUC0-inf)는 1을 초과하고, 이것은 SC 투여 후 완전한 흡수를 제안한다.
약동학/ 약역학 모델링
BMS-986003의 PD를 PK/PD 연구에서 항-KLH 항체 반응의 억제로서 측정하였다. BMS-986003은 20 mg/kg의 최고 용량에서 KLH에 대한 항체 반응을 70% 억제하였다 (% 억제된 반응 =
Figure pct00161
). 2 및 0.2 mg/kg에서 항체 반응의 억제는 미미하거나 (15%) 없었다. 비교하면, 5c8-IgG1은 동일한 용량 수준 (20 mg/kg)에서 BMS-986003보다 10배 더 높은 혈장 노출 및 4배 더 긴 T1/2을 보였다. 그 결과, 5c8-IgG1은 항-KLH 항체 반응을 97% 억제하였다. BMS-986003 및 5c8-IgG1 사이의 생체내 효능을 비교하기 위해, PK/PD 모델링은 SAAM II (버전 1.2.1, 미국 워싱턴주 시애틀)을 사용하여 수행하였다. SC 투여 후 BMS-986003의 혈장 농도는 2-구획 모델과 결합된 1차 흡수 운동학을 이용하여 설명하였고, 여기서 소거는 중심 및 말초 구획 모두에서 일어났다. 면역원성으로 인한 문제 및 가능한 비선형 흡수 때문에, PK 데이터를 각각의 용량에서 개별적으로 피팅하였다.
5c8-IgG1에 대해, 중심 소거가 있는 2-구획 모델을 사용하였다. 항-KLH 항체 반응 (IgG 역가의 평균값으로서 표현함)을 6-구획 신호 전달 모델에서 모델링하였다. 신체 내에서 KLH의 동역학은 1-구획 모델인 것으로 가정하였다. BMS-986003 및 5c8-IgG1에 의한 IgG 생산의 억제는 Imax 모델을 이용하여 설명하였고, 여기서 최대 억제는 100%이었다. 도 14에 도시된 바와 같이, 모델-피팅된 곡선은 PK 및 PD 프로파일을 모두 설명할 수 있었다. KLH-유도된 IgG 생산의 억제를 위한 BMS-986003 및 5c8-IgG1의 혈장 IC50은 각각 74±14 및 60±18 nM인 것으로 추정되었다. 이들 결과는 이들 2개의 분자의 효능이 생체 내에서 대등한 것을 입증하였다.
BMS-986004의 CD40L 수용체 점유 (RO)를 IV PK 연구에서 측정하였다. 11 mg/kg의 IV 투여 후에, 말초 혈액 단핵 세포 (PBMC) 상의 BMS-986004의 RO는 시간- 및 농도-의존적이었다. RO EC50를 추정하기 위해 PK/PD 모델링을 수행하였다. 혈장 농도는 추가의 ADA-매개된 1차 제거 상수를 투여 504 h 후에 도입한 변형된 2-구획 모델을 사용하여 모델링하였고; RO는 다음 Emax 모델을 이용하여 모델링하였다: (
Figure pct00162
). 도 15에 도시된 바와 같이, 피팅된 곡선은 노출 및 RO를 모두 설명할 수 있었고, 여기서 추정된 RO EC50은 3.4±0.3 nM이고, γ (힐 (hill) 인자)는 3.1±0.1이었다. 비교하면, RO EC50은 74±14 nM의 항-KLH 항체 반응 IC50보다 ~22배 더 낮았고, 이것은 뚜렷한 (>50%) 항-KLH 항체 억제를 달성하기 위해 >95% RO가 요구됨을 제안한다.
실시예 10
비임상 독성학 단일-용량 PK / PD 연구
본 연구의 목적은 1) 원숭이에게 단일 용량으로서 피하 투여될 때 그의 잠재적인 면역원성을 비롯한 BMS-986003의 관용성을 결정하고; 2) 그의 PD (예를 들어, T-세포-의존성 항원에 대한 항체 반응의 억제) 및 PK 프로파일을 평가하고; 3) 피하 투여 후에 BMS-986003의 수용체 점유 및 말초 T-세포 계수를 평가하고; 4) 신장 이식 연구 및 최초 인간 적용 (first-in-human) 투여를 위한 용량 선택을 돕기 위한 것이었다.
BMS-986003을 성별당 2마리의 시노몰구스 원숭이의 군에 0 (비히클 대조군), 0.2, 2, 또는 20 mg/kg의 단일 용량으로서 전방 가슴에 s.c. 투여하였다. 성별당 추가의 2마리 원숭이에게 20 mg/kg 5c8-IgG1 (본 연구에서 양성 대조군으로서 사용된 인간 CD40L에 대한 모노클로날 항체)의 단일 정맥내 용량을 투여하였다. 모든 용량은 비히클 (PBS; pH 7.2) 내의 2 mL/kg에서 투여하였다. T-세포 의존적 항체 반응에 대한 효과를 평가하기 위해, 동물을 시험 품목 투여 약 24시간 후에 또는 양성 대조군 투여 직후에 근육내 주사 (전방 사두근 또는 후방 대퇴근)에 의해 10 mg의 KLH로 면역화시켰다. 평가를 기준은 생존, PK, 면역원성, PD (T-세포-의존성 항원 KLH에 대한 항체 반응의 억제), 임상 징후, 체중, 식품 소비, 말초 혈액 면역표현형 결정, 수용체 점유, 및 임상-병리학 평가 (혈액학, 혈청 화학, 및 응고)를 포함하였다. 동물을 6-주 투여 후 관찰 기간 후에 무리로 돌려보냈다.
용량≤20 mg/kg에서, BMS-986003은 서서히 흡수되었고 (Tmax = 6-96 h), Cmax 및 AUCtot 값은 모든 용량군에 걸쳐 용량-비례적 방식이 아닌 방식으로 증가하였고, 명백한 성별 차이는 없었다. 추정된 T1/2 값은 모든 용량에 걸쳐 69-104 h 범위였다. BMS-986003은 실질적으로 면역원성이고; 모든 원숭이는 6-주 투여 후 기간 동안 양성 항-약물 항체 (ADA) 반응을 일으켰다. 0.2 및 2 mg/kg에서, 평균 군 총 ADA 반응은 제22일에 최고치였고, 여기서 평균 군 종점 역가 (EPT)는 각각 4203 및 6469이었다. 20 mg/kg에서, ADA 반응은 양성이지만 다소 지연되고 부분적으로 억제되었고, 이것은 표적 약물학과 일치하고, 제36일에 최고치였고, 여기서 평균 군 EPT는 1828이었다. 항체의 추가의 특성화는 이들 항체 및 분자의 dAb (비-Fc) 부분에 대한 대부분의 결합이 2가지 상이한 면역검정 포맷에서 CD40L에 대한 BMS-986003의 결합을 차단하는 것으로 나타났음을 입증하였고, 이것은 ADA가 중성성임을 제안한다. 추가로, ADA의 형성은 몇몇 원숭이에서 BMS-986003의 소거를 가속화하는 것으로 보였다.
BMS-986003에 대한 평균 PK 파라미터를 표 14에 제시한다.
Figure pct00163
체중 또는 임상 병리학 파라미터에 대한 BMS-986003- 또는 5c8-IgG1-관련 임상 관찰 또는 효과는 없었고, 단, 5c8-IgG1으로 처리한 1마리의 수컷은 제8일에 감소된 적혈구 (0.74x 대조군), 헤모글로빈 (0.73x 투여 전) 및 헤마토크릿 (0.75x 투여 전)을 보였고, 5c8-IgG1을 투여한 4마리 원숭이 중 3마리는 제8일에 감소된 림프구 (0.53x 내지 0.65x 투여 전)를 보였고, 이것은 림프구 고갈을 제안한다.
CD40L 수용체 점유는 전체적으로 시간- 및 용량-의존적이고, 20 mg/kg BMS-986003의 투여 후에 보다 지속적이었고, 이것은 상기 용량 및 PD 활성에서 보다 높고 보다 지속적인 노출과 일치한다. BMS-986003에 대해, 말초 혈액 단핵 세포 (PBMC) 상의 평균 피크 수용체 점유는 0.2, 2, 또는 20 mg/kg에서 각각 투여 후 24 hr (97%), 6 hr (99%) 또는 48 hr (99%)에 달성되었고, 240, 360, 또는 696 hr에 <90% 점유로, 및 360, 696, 또는 1032 hr에 <50% 점유로 감소하였다. 비교하면, 20 mg/kg에서 5c8-IgG1에 대해, PBMC 상의 평균 피크 수용체 점유는 48시간에 달성되었고 (≥100%), 전체 연구 동안 ≥97% 지속하였다 (1032 hr 또는 제44일까지).
BMS-986003은 20 mg/kg의 고용량에서만 KLH에 대한 항체 반응을 억제하였다. 20 mg/kg에서 8-30일에, 대조군에 비해 KLH에 대한 기하 군 평균 항체 반응의 69 내지 83% 억제가 있었고, 여기서 83%의 피크 억제는 제16일에 발생하였다. 항체 반응의 억제는 0.2 또는 2 mg/kg BMS-986003에 일어나지 않았다. 이들 데이터는 적어도 1개월 동안 >90%의 지속적인 수용체 점유에서 및 제11일까지 ~10 ㎍/mL 초과의 지속적인 혈장 농도에서 BMS-986003이 시노몰구스 원숭이에서 T-세포 의존적 항체 반응을 억제할 수 있음을 입증한다. 양성 대조군 항체 5c8-IgG1에 대해, KLH에 대한 기하 군 평균 항체 반응의 74-97%의 억제가 제8-30일에 일어났고, 여기서 제16일에 97%의 피크 억제가 있었고 이것은 일반적으로 제30일까지 지속하였다.
B 세포 (CD45+, CD20+, CD3-), 총 T (CD45+, CD3+) 세포, 헬퍼 T (CD45+, CD3+, CD4+, CD8-) 세포, 세포독성 T (CD45+, CD3+, CD4-, CD8+) 세포, 또는 자연 킬러 (CD45+, CD3-, CD16+) 세포의 절대적인 수에서 생물학적 관련 BMS-986003 관련된 변화는 연구 동안 일어나지 않았고, 이것은 임의의 Fc 이펙터 기능의 결여를 확인한다. 그러나, 제8일에, 20 mg/kg 5c8-IgG1로 처리한 4마리 원숭이 중 3마리는 T-림프구 (0.53x 내지 0.66x 투여 전) (헬퍼 T-세포 (0.64x 내지 0.77x 투여 전) 및 세포독성 (0.40x 내지 0.61x 투여 전) T-세포 집단 모두)가 감소하였고, 이것은 고갈을 제안한다.
결론적으로, 0.2, 2, 또는 20 mg/kg의 단일 SC 용량으로 투여한 BMS-986003 (AUC≤14195 ㎍*hr/mL)은 시노몰구스 원숭이에서 유해 약물-관련 효과 없이 잘 관용되었다. 양성 대조군인 5c8-IgG1은 20 mg/kg의 용량에서 KLH에 대한 항체 반응의 완전한 지속적인 억제, 및 투여 후 30일까지 거의 100%의 지속적인 수용체 점유를 일으켰다. T-세포의 온화한 고갈이 또한 5c8-IgG1을 투여한 원숭이에서 제8일에 인지되었고 (0.40x 내지 0.77x 투여 전), 이것은 BMS-986003에서는 관찰되지 않았다. BMS-986003은 제1일에 KLH 면역화 이후 20 mg/kg에서 KLH에 대한 항체 반응을 억제할 수 있었고 (83%의 피크 억제), 제22일까지 ≥90% 및 제29일까지 ≥50%의 지속적인 수용체 점유를 가졌다. BMS-986003에 대한 면역원성의 유사한 감소는 20 mg/kg에서 일어났다. 그러나, 0.2 및 2 mg/kg의 보다 낮은 BMS-986003 용량은 항-약물 항체 반응 또는 KLH에 대한 항체 반응을 억제하지 않았다. 보다 낮은 용량에서 약물학의 결여는 또한 아마도 ADA의 형성으로 인한 감소하는 수용체 점유 (즉, 제11일 [0.2 mg/kg] 또는 제16일 [2 mg/kg]에 <90%; 제16일 [0.2 mg/kg] 또는 제30일 [2 mg/kg]에 <50%) 및 가속화 클리어런스과 상호관련되었다. TDAR의 억제는 상기 화합물의 작용 메카니즘과 일치하고, 유해한 것으로 간주하지 않았다.
실시예 11
TE /혈전증에 대한 위험의 평가
항-CD40L 모노클로날 항체의 투여와 연관된 TE가 활성화 및 응집을 유발하는, FcgRIIa (IgG Fc 수용체)에 대한 IC 결합에 의해 촉진된 혈소판의 항-CD40L mAb-CD40L 면역 복합체 (IC)-매개된 가교 결합에 의해 매개되는 것으로 가정되었다 (도 10). 따라서, IgG의 Fc 모이어티와 FcgRIIa의 상호작용을 차단하는 것은 혈소판 가교 결합 및 혈전증을 경감시키는 것으로 예상된다. 다음 방법 및 방안은 TE 및/또는 혈전증의 위험을 평가하기 위해 설계되었다.
시험관내 혈소판 활성화 검정
혈소판이 CD40L mab/sCD40L IC에 의해 FcgRIIa-의존적 방식으로 활성화된다는 가설을 시험하기 위해 몇몇 시험관내 검정을 수행하였다. BMS-986003 및 BMS-986004를 시험하기 전에 검정을 검증하기 위해 양성 대조군 5c8-IgG1을 사용하였다. 이들 연구를 위해 혈소판 상에 hFcgRIIa 수용체를 발현하는 마우스 또는 인간 공여자로부터의 혈액을 사용하였다. 혈소판 활성화는 잘 검증된 혈소판 활성화 마커 P-셀렉틴 (CD62P) 및 PAC-1 (활성화된 GPIIb/IIIa)에 대한 항체를 사용하는 유동 세포 측정에 의해 검출하였다. 간단히 설명하면, 혈액을 1 mM CaCl2를 함유하는 변형 Tyrodes-HEPES 내에 1:25 희석하고, 여기에 검출 항체 및 시험 시약을 첨가하고, 인큐베이션하고, 혈소판 활성화에 대해 분석하였다. 초기 실험은 sCD40L 또는 5c8IgG1은 단독으로 혈소판을 활성화시키지 않지만, 5c8:sCD40L의 1:1 내지 1:8의 상이한 면역 복합체 비가 혈소판을 유의하게 활성화시켰음을 결정하였다. 후속 실험에서는 5c8-IgG1 또는 5c8-mIgG2a IC를 대부분 5c8:sCD40L의 1:3 몰비로 사용하였다.
5 c8 / sCD40L IC 에 의한 혈소판 활성화는 항- FcgRIIa 항체에 의해 차단될 수 있다.
5c8/sCD40L IC에 의한 혈소판의 활성화가 실제로 FcgRIIA-매개되는지 시험하기 위해, FcgRIIa 차단 항체 IV.3을 사용하여 연구를 수행하였다. 인간 공여자로부터의 혈액을 0.5 ㎍/㎕의 FcgRIIa 차단 항체 IV.3와 함께 예비-인큐베이션한 후, 상기 설명된 바와 같이 희석하고 검출 항체와 함께 인큐베이션하였다. 아데노신 디포스페이트 (ADP) (상이한 메카니즘을 통한 혈소판 활성화제)를 양성 대조군으로서 사용하였다. 도 16에 예시된 바와 같이, 5c8/sCD40 IC에 의한 혈소판 활성화는 IV.3에 의해 완전히 차단된 반면, ADP에 의한 활성화는 차단 항체에 의해 억제되지 않았고, 이것은 IC에 의한 활성화가 FcgRIIa-매개된 것임을 나타낸다.
불활성 Fc 테일의 선택
잠재적인 후보 분자에 대한 요건은 잠재적인 혈소판 활성화를 방지하기 위해 FcgRIIa에 대한 결합의 부재이다. IgG1 (예를 들어, 5c8-CT 및 N297Q) 또는 IgG4 (예를 들어, 5c8-S228P)로부터 유래한 상이한 돌연변이를 함유하는 몇몇 5c8 구축물을 발현시키고, 상이한 몰비의 sCD40L 대 mAb를 사용하여 혈소판을 활성화시키지 않은 Fc 테일에 대해 스크리닝하였다. 5c8-CT 및 5c8-N297Q를 제외한 대부분의 돌연변이된 구축물 및 야생형은 혈소판을 활성화시켰다 (도 17). Fc의 부재 (5c8-Fab2)는 또한 혈소판을 활성화시키지 않았고, 이것은 IC-혈소판 활성화가 Fc-매개됨을 추가로 확인하였다. dAb 후보 BMS-986003 및 BMS-986004를 포맷하기 위해 CT 테일을 선택하였다.
혈소판 활성화에 대한 FcgRIIa 다형성의 효과
FcgRIIa에 대한 유전자는 코돈 131에서 가변적이어서, His-Arg (C A T/C G T) 다형성을 일으킨다. 대략 동일한 분포의 백인 및 아프리카계 미국인의 대략 100명의 개체에서 유전자형 분포는 백인 미국인에 대해 A/A (His 동형접합성; 14%), A/G (His/Arg 이형접합성; 60%), 및 G/G (아르기닌 동형접합성; 26%), 및 아프리카계 미국인에 대해 A/A (30%), A/G (51%), 및 G/G (19%)이었다 (문헌 [Reilly et al., Clin. Diagn. Lab. Immunol. 1: 640-644 (1994)]). Fc-의존적 혈소판 응집은 mIgG2 또는 mIgG1 Fc 형식의 항-CD9로 처리한 R131 개체로부터의 샘플에서 인지된 반면, H131 개체로부터의 혈소판은 mIgG2 형식으로서 항-CD9에서만 응집하였고; 이것은 IgG1 mAb를 사용한 Fc-의존적 응집이 환자 집단을 저 응답자 및 고 응답자로 잠재적으로 구분할 수 있음을 제안하고, 이것은 상기 다형성에서 이전에 보고되었다 (문헌 [Tomiyama et al., Blood 80: 2261-2268 (1992)]). IgG1 및 CT Fc 테일을 사용한 혈소판 활성화에서 임의의 잠재적인 차이를 처리하기 위해, 19명의 공여자를 hFcgRIIa 다형성에 대해 유전자형 결정하고, 샘플을 혈소판 활성화에 대해 시험하였다. 공여자 풀 다형성 (RR; 42%, HH; 21%, HR; 37%)은 IgG1 형식에 대한 혈소판 활성화에 있어서 임의의 잠재적인 차이를 평가하기 위해 충분하였다. 대표적인 문헌은 5c8-IgG1/sCD40L IC를 사용한 혈소판 활성화가 모든 유전자형이 결정된 개체 사이에서 유사하였음을 보고한다. 5c8-CT/sCD40L IC에서 활성화는 발견되지 않았고 (도 18), 이것은 CT 테일로 포맷된 항체를 사용한 환자 집단에서 증가된 TE의 위험이 적거나 없음을 제안한다.
BMS -986004: 인간 혈액 공여자에서 혈소판 활성화
5c8을 사용하여 상기 설명된 실험은 BMS-986004에 대한 최상의 형식으로서 CT-테일의 선택을 지지하였다 (또한, BMS2h-572-633-CT-L2로 불림). 6명의 공여자로부터 입수한 혈액을 5c8-IgG1, 5c8-CT, F(ab)2, 및 BMS-986004로 처리하였다. 혈소판은 5c8-IgG1에 의해 활성화되었지만, BMS-986004를 비롯한 임의의 다른 구축물에 의해 활성화되지 않았고 (도 19), 이것은 상기 dAb가 임상 연구에서 혈소판 활성화 및 TE를 일으킬 위험이 적거나 없음을 제안한다.
BMS -986003: hFcgRIIa 를 발현하는 마우스로부터의 혈액에서 혈소판 활성화
항-CD40L 항체에 의한 혈소판의 활성화가 FcgRIIa 수용체에 의해 매개되는지 추가로 확인하기 위해, 인간 수용체 (R131 유전자형)를 발현하는 트랜스제닉 마우스로부터 혈액을 5c8-IgG1, 5c8-IgG2a, dAb-IgG1, 5c8-CT, 및 BMS-986003 (또한 BMS-2h572-633-CT로 불림)로 처리하였다. 혈소판은 hFcgRIIa를 발현하는 마우스로부터 혈액에서 5c8-IgG1, 5c8-IgG2a, 및 dAb-IgG1/sCD40L IC에 의해 특이적으로 활성화되었지만, 야생형 한배새끼에서는 그렇지 않았다. 5c8-CT 및 BMS-986003은 혈소판을 활성화시키지 않았고, 이것은 본원에 개시된 항체를 사용할 때 TE에 대한 낮은 위험을 추가로 확인한다 (도 20).
실시예 12
에피토프 결합 실험
도 25는 1가 dAb 분자 BMS2h-503-1, BMS2h-572-6, BMS2h-719-17, 및 1가 항-CD40L 5c8 Fab 단편이 CD40L에 대한 결합에 대해 서로 경쟁하는지 여부를 시험하기 위해 설계된 실험에 대한 SPR 센서그램 데이터를 보여준다. 실험은 스트렙타비딘 센서 칩 표면 상에 포획된 비오티닐화된 CD40L (biot-IZ-hCD40L)을 사용하여 수행하였다. 시험은 명시된 분자의 순차적인 주사 (시기 "a"), 바로 이어서 제2 명시된 분자의 존재 하에 동일한 분자의 주사 (시기 "b"), 이어서 해리 (시기 "c")를 포함하였다. 결합에 대한 경쟁은 제1 분자의 존재 하에 제2 분자에 대한 결합 신호의 감소 (차단)로서 확인되고, 여기서 차단 수준은 각각의 분자의 결합 및 해리 운동학에 의해 좌우된다. 시험한 분자의 각각의 쌍에 대해, 제2 분자의 결합은 제1 분자가 존재할 때 감소한 것으로 나타났다. 이들 결과는 BMS2h-503-1, BMS2h-572-6, BMS2h-719-17, 및 5c8 Fab가 biot-IZ-hCD40L에 대한 결합에 대해 서로 경쟁함을 제안한다.
도 26은 인간 CD40L 단량체 (삼중 CD40L 돌연변이체 (T211E, S222Y, H224K [108-261])) 또는 CD40L 삼량체 (IZ-hCD40L)에 대한 지시된 dAb-CT-긴 및 5c8-CT-긴 분자의 결합에 대한 SPR 센서그램 데이터를 보여준다. dAb-CT-긴 및 5c8-CT-긴 분자를 고정된 항-인간 IgG Fc (비아코어, 지이 헬쓰케어) 항체 센서 칩 표면 상에 이들의 "CT-긴" Fc-도메인을 통해 포획하였다. 상부 3개의 패널의 결과는 인간 CD40L 단량체가 BMS2h-719-202-CT-긴 및 5c8-CT-긴에 특이적으로 결합하지만, BMS2h-572-6 계통으로부터 dAb를 함유하는 임의의 지시된 dAb-CT-긴 분자에 결합하지 않음을 보여준다. 이와 반대로, 저변 3개의 패널은 CD40L 삼량체 (IZ-hCD40L)가 BMS2h-572-6 계통으로부터의 모든 시험한 dAb-CT-긴 분자에, 및 BMS2h-719-202-CT-긴 및 5c8-CT-긴에 강하게 결합함을 보여준다. 이들 결과는 BMS2h-572-6xx-CT-긴 계통으로부터의 분자는 CD40L 삼량체 상에만 존재하고 단량체성 인간 CD40L 상에 존재하지 않는 에피토프에 특이적인 반면, BMS2h-719-202-CT-긴 및 5c8-CT-긴은 CD40L 단량체 및 삼량체 모두에 존재하는 에피토프에 결합함을 제안한다.
본 실시양태는 상기 실시예를 참조하여 상세히 설명하였지만, 이들 실시양태의 취지로부터 벗어나지 않으면서 다양한 변형이 이루어질 수 있고, 숙련된 당업자에게 쉽게 알려질 것임이 이해된다.
SEQUENCE LISTING <110> BRISTOL-MYERS SQUIBB COMPANY DOMANTIS LIMITED <120> ANTIBODY POLYPEPTIDES THAT ANTAGONIZE CD40L <130> 200896-0005-WO (489826) <140> <141> <150> 61/655,110 <151> 2012-06-04 <150> 61/546,800 <151> 2011-10-13 <160> 1365 <170> PatentIn version 3.5 <210> 1 <211> 261 <212> PRT <213> Homo sapiens <400> 1 Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 1 5 10 15 Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 20 25 30 Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 35 40 45 Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 50 55 60 Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 65 70 75 80 Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 85 90 95 Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 100 105 110 Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 115 120 125 Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 130 135 140 Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 145 150 155 160 Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 165 170 175 Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 180 185 190 Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 195 200 205 Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 210 215 220 Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 225 230 235 240 Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 245 250 255 Gly Leu Leu Lys Leu 260 <210> 2 <211> 5 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <220> <221> VARIANT <222> (2)..(2) <223> /replace="Gln" <220> <221> misc_feature <222> (2)..(2) <223> /note="Residue given in the sequence has no preference with respect to the annotation for said position" <400> 2 Trp Glu Leu Met Gly 1 5 <210> 3 <211> 17 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 3 Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 4 <211> 7 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <220> <221> VARIANT <222> (2)..(2) <223> /replace="Glu" <220> <221> VARIANT <222> (3)..(3) <223> /replace="Ser" <220> <221> VARIANT <222> (4)..(4) <223> /replace="Asn" or "Arg" <220> <221> misc_feature <222> (2)..(4) <223> /note="Residues given in the sequence have no preference with respect to those in the annotations for said positions" <400> 4 Lys Asp Ala Lys Ser Asp Tyr 1 5 <210> 5 <211> 30 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 5 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn 20 25 30 <210> 6 <211> 14 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <220> <221> VARIANT <222> (2)..(2) <223> /replace="Val" <220> <221> misc_feature <222> (2)..(2) <223> /note="Residue given in the sequence has no preference with respect to the annotation for said position" <400> 6 Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 1 5 10 <210> 7 <211> 34 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 7 Arg Thr Phe Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Lys 20 25 30 Val Gly <210> 8 <211> 11 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 8 Arg Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 <210> 9 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <220> <221> VARIANT <222> (30)..(30) <223> /replace="Asn" <220> <221> VARIANT <222> (31)..(31) <223> /replace="Lys" or "Ser" or "Thr" <220> <221> misc_feature <222> (30)..(31) <223> /note="Residues given in the sequence have no preference with respect to those in the annotations for said positions" <220> <221> VARIANT <222> (35)..(35) <223> /replace="Gln" <220> <221> misc_feature <222> (35)..(35) <223> /note="Residue given in the sequence has no preference with respect to the annotation for said position" <220> <221> VARIANT <222> (62)..(62) <223> /replace="Glu" <220> <221> misc_feature <222> (62)..(62) <223> /note="Residue given in the sequence has no preference with respect to the annotation for said position" <220> <221> VARIANT <222> (98)..(98) <223> /replace="Glu" <220> <221> misc_feature <222> (98)..(98) <223> /note="Residue given in the sequence has no preference with respect to the annotation for said position" <220> <221> VARIANT <222> (103)..(103) <223> /replace="Met" or "Leu" <220> <221> misc_feature <222> (103)..(103) <223> /note="Residue given in the sequence has no preference with respect to those in the annotations for said position" <400> 9 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Phe Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 10 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <220> <221> VARIANT <222> (28)..(28) <223> /replace="Asp" <220> <221> misc_feature <222> (28)..(28) <223> /note="Residue given in the sequence has no preference with respect to the annotation for said position" <400> 10 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His His Ile Gln Arg Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Leu Trp Gly Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Trp Trp Ala Pro Pro Gln 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 11 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <220> <221> VARIANT <222> (14)..(14) <223> /replace="Tyr" <220> <221> misc_feature <222> (14)..(14) <223> /note="Residue given in the sequence has no preference with respect to the annotation for said position" <220> <221> VARIANT <222> (83)..(83) <223> /replace="Phe" <220> <221> misc_feature <222> (83)..(83) <223> /note="Residue given in the sequence has no preference with respect to the annotation for said position" <220> <221> VARIANT <222> (85)..(85) <223> /replace="Lys" <220> <221> misc_feature <222> (85)..(85) <223> /note="Residue given in the sequence has no preference with respect to the annotation for said position" <220> <221> VARIANT <222> (100)..(100) <223> /replace="Arg" or "Gln" <220> <221> misc_feature <222> (100)..(100) <223> /note="Residue given in the sequence has no preference with respect to those in the annotations for said position" <400> 11 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Lys Gly Thr Lys Val Val Ile Lys Arg 100 105 <210> 12 <211> 25 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <220> <221> VARIANT <222> (6)..(25) <223> /replace=" " <220> <221> misc_feature <222> (6)..(25) <223> /note="Residues given in the sequence have no preference with respect to the annotation for said positions" <220> <221> misc_feature <222> (1)..(25) <223> /note="This sequence may encompass 1 to 5 'Gly Gly Gly Gly Ser' repeating units" <400> 12 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser Gly Gly Gly Gly Ser 20 25 <210> 13 <211> 6 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 13 Thr Val Ala Ala Pro Ser 1 5 <210> 14 <211> 7 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 14 Ala Ser Thr Ser Gly Pro Ser 1 5 <210> 15 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 15 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ile Ala Tyr 20 25 30 Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Asp Glu Trp Gly Leu Gln Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Lys Thr Pro Glu Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 16 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 16 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Gly Glu Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Arg Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 17 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 17 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Tyr 20 25 30 Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile His Gly Ser Gly Ser Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Tyr Thr Ser Arg His Asn Ser Leu Gly His Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 18 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 18 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Met Asp Tyr 20 25 30 Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Pro Val Gly Met Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Tyr Gly Gly Thr Ser Gly Arg His Asn Thr Lys Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 19 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 19 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr 20 25 30 Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Ser Pro Leu Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Thr Gly Gly Ser Gly Ile Leu Asn Ser Ser Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 20 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 20 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Val Ser Asn Tyr 20 25 30 Asp Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Ala Thr Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ala Val Thr Trp Trp Leu Leu Arg His Asn Asp Asn Leu Gly Phe 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 21 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 21 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ile Ser Tyr Lys 20 25 30 Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Lys Ala Ala Asn Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr Gly Ser Gln Lys Lys Arg Thr Tyr Thr Phe Asp Phe Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 22 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 22 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Leu Tyr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Ile Leu Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Leu Ser Trp Gln Gly Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 23 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 23 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asn Pro Met Gly Tyr Gln Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys His Gly Val Gly Lys Gly Thr Lys Pro His Asn Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 24 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 24 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Leu Tyr 20 25 30 Arg Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Glu Ile Ser Gly Ser Gly Phe Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu His Asp Lys Thr Gln His His Gln Glu Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 25 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 25 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ile Glu Tyr 20 25 30 Pro Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Pro Ser Gly Val Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Glu Ser Ser Thr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 26 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 26 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Asp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Gly Ser Ser Gly Tyr Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Arg Met Pro Gly Tyr Phe Pro Gly Phe Ala Arg Gln Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 27 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 27 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Trp Arg Tyr 20 25 30 Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Asn Asp Glu Gly Arg Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Lys Arg Val Ser Ser Ser Val Asn Ala Pro Tyr Glu Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 28 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 28 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Tyr 20 25 30 Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Arg Leu Gly Thr His Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Leu Ala Asp Leu Ile Ala Gly His Ala Glu Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 29 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 29 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Ser Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Arg Ser Gly Ser Met Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Val Asp Ala His Val Tyr Tyr Met Glu Pro Phe Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 30 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 30 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Ser Asp Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Thr Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 31 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 31 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Lys Tyr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Gly Asp Gly Lys Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Gln Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 32 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 32 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 20 25 30 Ser Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro Phe Gly Trp Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Tyr Gly Glu Thr Ser Gly Pro Ile Ser Glu Asn Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 33 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 33 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ala Gly Tyr 20 25 30 Gln Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Asn Glu Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Lys Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 34 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 34 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Tyr 20 25 30 Glu Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser Asp Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Ile Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 35 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 35 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Val Asp Asp Gly Leu Met Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Val Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Asn 115 <210> 36 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 36 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ile Gly Tyr 20 25 30 Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Pro Leu Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Pro Ala Gly Thr Ser Ser His Ser Val Asp Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 37 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 37 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser Asp Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Ser Val Gln Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 38 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 38 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Val Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Glu Ala Asp Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Leu Thr Asp Gln His Val Ile Glu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 39 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 39 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Tyr 20 25 30 Arg Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ala Pro Asp Gly Asn Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Phe Trp Gly Met Gln Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 40 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 40 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Ser Tyr 20 25 30 Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Pro Ile Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Met Lys Ser Pro Tyr Lys Pro Gln Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 41 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 41 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Ala Tyr 20 25 30 Trp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro Ser Gly Thr His Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Tyr Thr Glu Pro Gly Leu Gly Ser Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 42 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 42 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Ser Glu Val Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro His Asp Ser Ser Ile Gly Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 43 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 43 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Trp Ser Tyr 20 25 30 Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Met Ala Ser Gly Asp Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Asp Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 44 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 44 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Tyr 20 25 30 Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Ile Gly Leu Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Phe Pro Leu Ile Ile Leu Pro Asp Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 45 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 45 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Met Glu Tyr 20 25 30 Ala Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ile Ile Ser Pro Leu Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Tyr Gln Asp Ser Ser Asp Ser Gln Tyr Thr Asn Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 46 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 46 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Tyr 20 25 30 Gly Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Pro Leu Gly Leu Trp Thr Tyr Tyr Ala Asp Ser Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Pro Leu Glu Gly Leu Ile Thr Asn Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 47 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 47 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Tyr 20 25 30 Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ile Ile Asp Trp Asp Gly Asn Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Asp Asn Val Gly Ile Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 48 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 48 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Tyr Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Asp Glu Trp Gly Phe Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys His Trp Glu Phe Thr Ser Asp Thr Ser Arg Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 49 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 49 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Phe 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asn Asp Gln Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Gln Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 50 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 50 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Asp Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Ser Pro Gln Gly Gln Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Gly Gln Ser Arg Ile Pro Met Arg Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 51 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 51 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Glu Tyr 20 25 30 Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Ser Asp Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro His Gly Ser Pro Arg Glu Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 52 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 52 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 20 25 30 Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Ser Leu Gly Glu Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Arg Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 53 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 53 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Phe Tyr 20 25 30 Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Asp Ala Thr Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Gly Asn Tyr Gly Ser Ser Tyr Thr Met Gly Val Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 54 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 54 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Tyr 20 25 30 Pro Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Pro Ser Gly Pro Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Pro Tyr Phe Asp Val Ile Pro Ser Tyr Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 55 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 55 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30 Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gln Ser Ser Gly Leu Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Ala Asn Ser Arg Arg Gly Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 56 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 56 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser His Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Lys Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 57 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 57 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala His Tyr 20 25 30 Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Arg Leu Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Ala Thr Pro Val Pro Ile Lys Gly Leu Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 58 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 58 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Gly Arg Tyr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Ser Asp Gly Trp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gln Pro Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 59 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 59 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ser Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Arg Gly Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Trp Arg Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 60 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 60 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Arg Tyr 20 25 30 Arg Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Arg Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Met Thr Ala Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 61 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 61 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Met Tyr 20 25 30 Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Met Ile Glu Pro Ala Gly Asp Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Tyr Gln Glu Gln Pro Trp Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 62 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 62 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Pro Gln Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Met Ile Thr Ser Asp Gly Leu Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Glu Pro Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 63 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 63 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Met Tyr 20 25 30 Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Leu Ser Asp Gly Thr Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Tyr Gly Ala Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 64 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 64 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Leu Tyr 20 25 30 Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Ala Gly Gly His Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Trp Trp Asp Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 65 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 65 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 20 25 30 Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asn Arg Ser Gly Met Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Gly His Gln Ala Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 66 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 66 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Gly Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Asn Ala Asn Gly Ile Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Gly Val Trp Arg Trp Gly Thr Gly His Lys Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 67 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 67 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Gln Tyr 20 25 30 Asp Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Gln Asn Gly Thr Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Arg Thr Gly Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 68 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 68 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Asn Trp Gln Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Gly Phe Gly His Tyr Val Asp Gly Leu Gly Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 69 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 69 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Asp Met Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Thr Ala Phe Asp Tyr Trp Gly Pro Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 70 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 70 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Lys Tyr 20 25 30 Lys Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Pro Lys Gly His Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Pro Met Thr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 71 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 71 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Tyr 20 25 30 Asn Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Pro Arg Gly Gly Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Arg Arg Glu Gly Tyr Thr Gly Ser Lys Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 72 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 72 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Tyr 20 25 30 Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Trp Pro Arg Gly Gln Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Asn Ser Arg Tyr Val Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 73 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 73 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Ser Asp Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Phe Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Gly Arg Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 74 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 74 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Ser Glu Gly Leu Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Gly Arg Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 75 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 75 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 20 25 30 Ser Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Arg Pro Asn Gly Thr Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Ser Ser Ala His Leu Gln Arg Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 76 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 76 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Tyr 20 25 30 Ser Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Arg His Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Lys Gly Ser Thr Tyr Pro Arg Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 77 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 77 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser His Tyr 20 25 30 Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Pro Phe Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Tyr Pro Gln Gly Ser Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 78 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 78 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Pro Asp Gly Lys Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Val Tyr Ser Ser Cys Ala Met Cys Thr Pro Leu Leu Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 79 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 79 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Ser Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Asp Ile Gly Pro Arg Gly Phe Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Arg Gly Gln Arg Asp Thr Ser Gln Pro Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 80 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 80 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Ser Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Ser Gly Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 81 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 81 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Ser Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Ser Asp Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Val Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 82 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 82 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Lys Tyr 20 25 30 Leu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Pro Leu Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Glu Ala Ser Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 83 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 83 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Asn Val Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Lys Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 84 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 84 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30 Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Arg Gln Gly Phe Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Leu Glu Arg Asp Asp Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 85 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 85 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Tyr 20 25 30 Glu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Ser Glu Trp Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Val Gly Gly Thr Gln Tyr Glu Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 86 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 86 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Asn Tyr 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Gly Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Val Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 87 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 87 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Leu Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Gly Asp Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Gly Arg Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 88 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 88 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser Glu Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Lys Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 89 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 89 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser Glu Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Val Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Lys Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 90 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 90 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Ser Gln Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Arg Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 91 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 91 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser Asp Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Lys Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 92 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 92 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Leu Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser Asp Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Ser Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 93 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 93 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly His Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Asp Asn Gly Asn Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 94 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 94 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Arg Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Arg Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 95 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 95 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Arg Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Asp Asp Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Asp Lys Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 96 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 96 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Asp 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Asp Thr Thr Gly Gly Gln Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Lys Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 97 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 97 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Ser 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Leu Asp Glu Gly Ser Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Lys Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 98 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 98 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Glu 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Thr Asp Asp Gly Asp Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asn Ala Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 99 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 99 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Val Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Val Asn Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Lys Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 100 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 100 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Thr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ala Asp Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Gln Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 101 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 101 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Asp Asp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Leu Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 102 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 102 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Val Tyr 20 25 30 Gln Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Phe Ile Val Pro Gly Gly Asp Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Thr Trp Pro Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 103 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 103 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser Asp Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asn Pro Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 104 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 104 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Ala Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gln Ile Gly Arg Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Arg Arg Tyr Ala Ile Phe Thr Phe Asp Arg Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 105 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 105 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Gln Tyr 20 25 30 Pro Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Thr Asn Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Thr Asp Ile Ile Ser Ser Ser Glu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 106 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 106 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Phe Asn Tyr 20 25 30 Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Phe Val Trp Ser Ala Asp Ile Asp Phe Asp Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 107 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 107 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Trp Tyr 20 25 30 Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser His Ile Ala Ser Trp Gly Gly Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Thr Val Lys Asp Gly Gly Tyr Leu Met Asp Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 108 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 108 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Glu Tyr 20 25 30 Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Arg Asp Gly Ala Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Lys Ala Ala Lys Glu Arg Gly Ser Trp Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 109 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 109 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Ala Tyr 20 25 30 Gln Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Asn Gly Leu Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Leu Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 110 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 110 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Met Tyr 20 25 30 Ser Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Pro Arg Gly Val Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Asn Trp Asn Gly Val Asp Leu Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 111 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 111 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Tyr 20 25 30 Met Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Asn Thr Asn Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Ser Asn Met Ser Phe Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 112 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 112 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Gly Tyr 20 25 30 Ser Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asn Ala Ser Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Gly Asn Arg Ser Glu Val Phe Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 113 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 113 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Phe Glu Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ala Asn Asp Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Arg Gln Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 114 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 114 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Asp Tyr 20 25 30 Leu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Glu Ile Asn Gln Asp Gly Thr Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Ser Ser Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 115 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 115 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Arg Asp Gly His Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Ser Ser Lys Gly Gly Thr Phe Ala Ser Ser Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 116 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 116 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Val 20 25 30 Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Thr Asp Asp Gly Leu Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly His Ile Tyr Gly Asp Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 117 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 117 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Leu Tyr 20 25 30 Arg Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Ser Asp Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu His Trp Leu Gly Thr Thr Leu Ser Leu Arg Asp Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 118 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 118 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Arg Tyr 20 25 30 Thr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gln Ile Ser Pro Arg Gly Asn Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Gly Val Ala Gly Ala Glu Ser Pro Glu Tyr Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 119 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 119 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Gly Tyr 20 25 30 Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Gly Pro Ile Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Gln Asn Ile Tyr Gly Pro Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 120 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 120 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Gln Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Glu Ile Ser Arg Asp Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Glu Tyr Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 121 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 121 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Gln Tyr 20 25 30 Ser Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Leu Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Met Ser Lys Leu Leu Leu Ser Arg Glu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 122 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 122 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Met Tyr 20 25 30 Ser Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Pro Arg Gly Val Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Asn Trp Asn Gly Val Asp Leu Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 123 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 123 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Arg His 20 25 30 Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Thr Gly Asn Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Ala His Asp Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 124 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 124 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Pro Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Val Gly Asp Gly Leu Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 125 <211> 114 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 125 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Thr 20 25 30 Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Glu Ile Arg Asp Thr Gly Leu Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ser Val Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 100 105 110 Ser Ser <210> 126 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 126 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Leu Gly 20 25 30 Asp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Thr Gly His Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Met Asn Asp Gln Gly Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 127 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 127 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Met Asp Glu 20 25 30 Asp Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Asn Ser Leu Gly Thr His Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Phe Met Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 128 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 128 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asn Tyr 20 25 30 Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Ala Thr Gly Arg Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Thr Arg Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 129 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 129 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Ala 20 25 30 Asp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Tyr Leu Thr Ser His Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 130 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 130 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30 Ser Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Ser Gly Leu Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Trp Ser Gln Ala Val Thr Arg Ser Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 131 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 131 Glu Val Gln Leu Leu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Glu 20 25 30 Gly Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Glu Ile Asn Gln Gln Gly Ser Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Ile Gly Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 132 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 132 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Gln 20 25 30 Pro Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Ala Arg Gly Gly Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Phe Asp Ile Ile Ala Trp Asp Pro Phe Ser Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 133 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 133 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gln Tyr 20 25 30 Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Pro Ser Gly Phe Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Trp Asn Pro Phe Ile Thr Thr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 134 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 134 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly His Gln 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Asn Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Phe Asp Tyr Ser Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 135 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 135 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Ser Tyr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Ser Asp Gly Gly Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Arg Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 136 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 136 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Glu 20 25 30 Gln Met Thr Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro His Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Arg Thr Leu Val Asp Trp Pro Thr Ser Glu Ser Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 137 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 137 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 20 25 30 Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Pro Thr Gly Ile Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro His Phe Thr Glu Leu Gly Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 138 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 138 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Gly Glu 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Leu Pro Gly Pro Tyr Thr Phe Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Asn Gly Thr Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 139 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 139 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Tyr 20 25 30 Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Lys Ile Gly Ala Gln Gly Leu His Thr Tyr Tyr Ala Gly Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gln Thr Thr Met Asp Tyr Glu Arg Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 140 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 140 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Val 20 25 30 Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Gly Asn Asn Gly Leu Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Ala Leu Ser Tyr Arg Pro Pro Val Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 141 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 141 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Asp Asp 20 25 30 Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Leu Lys Gly Pro Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Arg Asp Gly Leu Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 142 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 142 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Ser Ser 20 25 30 Pro Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Arg Asp Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Ser Pro Tyr Arg Arg Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 143 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 143 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 20 25 30 Ser Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Val Ser His Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Lys Gly Tyr Asn Ala Gln Tyr Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 144 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 144 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly His Gln 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Asn Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Phe Asp Tyr Ser Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 145 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 145 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 20 25 30 Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Ser His Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Val Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 146 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 146 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly His Gln 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Asn Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Trp Ser Asp Ser Phe Asp Tyr Arg Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 147 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 147 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Gln Ser Asn Gly Asn Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Asn Ser Gln Val Glu Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 148 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 148 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Val Glu 20 25 30 Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Asn Ile Gly Arg Asp Gly Ser Met Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Gly Lys His Gly Thr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 149 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 149 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Glu Tyr 20 25 30 Arg Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Asp Glu Arg Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Arg Lys Gly Thr Lys Gln Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 150 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 150 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Leu Tyr 20 25 30 Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Gly Ala Val Gly Glu Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Glu Ala Asn Asn Leu Ser Asp Asn Leu Val Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 151 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 151 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly His Gln 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Asn Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Ser Val Glu Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 152 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 152 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 20 25 30 Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asn Pro Trp Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Leu Val Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 153 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 153 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Asp 20 25 30 Met Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Gln Leu Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gln Asn Trp Arg Thr Leu Thr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 154 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 154 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Tyr 20 25 30 Gly Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Leu Ser Asp Gly Val Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Ala Arg Gly Ala Asn Phe Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 155 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 155 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly His Tyr 20 25 30 Met Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Pro His Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Phe Asn Ala Ile Phe Ser Glu Ala Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 156 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 156 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30 Ser Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Ser Gly Leu Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Trp Ser Gln Ala Val Thr Arg Ser Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 157 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 157 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Leu Tyr 20 25 30 Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Met Ile Gly Arg Asp Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Ala Gly Ser Leu Arg Gly Arg Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 158 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 158 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Ala 20 25 30 Ser Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro His Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gln Arg Trp Gly Val Glu Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 159 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 159 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Gly Tyr 20 25 30 Ser Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ala Gly Arg Gly Gly Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Leu Tyr Ile Tyr His Ser Leu Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 160 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 160 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Gly Met 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Thr Gly Thr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Tyr His Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 161 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 161 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Met Val 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ala Arg Asp Gly Asn Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Ser Pro Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 162 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 162 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly His Gln 20 25 30 Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Asp Asp Gly Glu Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Tyr Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 163 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 163 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Tyr 20 25 30 Asn Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gln Ile Thr Arg Asp Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Ser Asn Ile Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 164 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 164 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Ser Met Ile Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Pro Tyr Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Asp Tyr Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 165 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 165 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 20 25 30 Ser Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Tyr Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Gly Leu Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 166 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 166 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Thr Gly 20 25 30 Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Gly Ile Gly Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Thr Pro Ser Asn Gln Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 167 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 167 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Gln Tyr 20 25 30 Gln Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Pro Ser Gly Phe Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Trp Asn Pro Phe Ile Ser Thr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 168 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 168 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Asn Tyr 20 25 30 Asp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ala Leu Gly Asn Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Thr Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Arg Ser Ala Ile Thr Gly Asn Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 169 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 169 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Glu Tyr 20 25 30 Gln Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Ser Gly Met Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Trp Arg Ser Val Val Arg Pro Trp Pro Gly Val Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 170 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 170 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Glu 20 25 30 Ser Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Pro His Gly Thr Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu His Leu Lys Leu Tyr Glu Ser His Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 171 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 171 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Gly Gly 20 25 30 Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Met Ile Pro Met Asp Gly Ser Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Gly Ser Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 172 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 172 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Phe Met 20 25 30 Pro Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Arg Asp Gly Ala Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Ala Ser Pro Ala Gln Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 173 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 173 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Glu 20 25 30 Pro Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Gly Thr Gly Thr Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Asn Gln Gly Asp Phe Ile Asn Arg Phe His Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 174 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 174 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Ala Tyr 20 25 30 Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Arg Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Pro Pro Pro Ser Ser His Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 175 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 175 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Tyr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser Asp Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 176 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 176 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Gly Tyr 20 25 30 Met Met Tyr Trp Val His Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro Gln Gly His Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Leu Arg Glu Leu Pro Arg Leu Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 177 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 177 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Ala Ser Gly Gly Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Asn Gly Lys Lys Phe Pro Phe Thr Lys Tyr Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 178 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 178 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Ser Val 20 25 30 His Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asn Leu Thr Gly Val Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Ala Thr Thr Arg Gln Ala His Pro Leu Tyr Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 179 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 179 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Glu Gly 20 25 30 Glu Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Thr Asn Gly Leu Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Thr Arg Asp Leu Gly Phe Ala Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 180 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 180 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Tyr 20 25 30 Glu Met Ala Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Phe Ile Ser Pro Arg Gly His Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Ala Lys Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 181 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 181 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Tyr 20 25 30 Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Ser Val Asp Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Arg Met Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 182 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 182 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Asn Ile Ser Arg Asp Gly Ser Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Ala Gln Ser Gly Gly Leu Arg Ser Gly Leu Thr Thr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 183 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 183 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Asp Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Arg Asp Gly Ala Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Gly Pro Lys Gly Ile Ala Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 184 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 184 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro His 20 25 30 Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Gly Gly Gly Ser Met Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Asp Pro Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 185 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 185 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Ala Gly 20 25 30 Glu Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Leu Pro Gly Asp Met Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asn Thr Gly Tyr Thr Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 186 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 186 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Trp Asp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gln Asn Thr Arg Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 187 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 187 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Asp Ala 20 25 30 Asp Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Leu Ser Pro Gly Glu Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Phe Gly Leu Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 188 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 188 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Asp 20 25 30 Gln Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro Ser Gly Ala Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Leu Gly Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 189 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 189 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Glu Gln Tyr 20 25 30 Gln Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Ser Pro Asp Gly Thr His Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Phe Ser Leu Arg Lys Met Glu Lys Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 190 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 190 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Asp Glu 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ala Ser Asp Gly Met Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gln Pro Gly Lys Asn Phe Asp His Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 191 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 191 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Thr Gly Gly Glu Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Trp Asn Leu Tyr Thr Glu Ser Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 192 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 192 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Gln 20 25 30 Pro Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ala Pro Asp Gly Ile His Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asn Leu Gly Gln Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 193 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 193 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Tyr 20 25 30 Gln Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro Ser Gly Thr Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Trp Lys Ala Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 194 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 194 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro His Ser 20 25 30 Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Leu Pro Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Phe Ser Asp Glu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 195 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 195 Glu Val Gln Leu Ser Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Gly 20 25 30 Asn Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Ser Asp Gly Val Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Arg Gly Gln Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 196 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 196 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Met Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro His Gly Val Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Leu His Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 197 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 197 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Thr Met Ala Trp Gly Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Phe Ile Ala Gly Pro Gly Asn Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Ser Thr Ala Thr Tyr Asn Asn Gly Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 198 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 198 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr 20 25 30 Ser Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Gly Arg Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Leu Lys Leu Val Arg Ala Pro Asn Pro Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 199 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 199 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Lys Thr Gly His Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Ser His Ser Leu Gly Pro Leu Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 200 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 200 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ala Tyr 20 25 30 Arg Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Ser Pro Ser Gly Ser Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Leu Thr Asp Ser Pro Ser Gly His Tyr Glu Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 201 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 201 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Arg Tyr 20 25 30 Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Thr Ala Gln Gly Leu Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Tyr Leu Thr Asp Phe Ser Ser Gly His Gln Glu Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 202 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 202 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser His Asn Gly Met Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Tyr Trp Pro Ser Thr Ser Trp Glu Thr Asp Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 203 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 203 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Glu 20 25 30 Pro Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Met Gln Gly Lys Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Arg Gly Gln Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 204 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 204 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Glu 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Cys Ile Asp Asn Leu Gly Ser Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Ile Ser His Gln Tyr Asp Arg Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 205 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 205 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Glu 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Glu Gly Gly Arg Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Trp Thr Pro His Lys Gln Leu Ser Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 206 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 206 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ala Asp Glu 20 25 30 Tyr Met Val Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Glu Ile Asp Pro Leu Gly Thr Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Tyr Gly Thr Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 207 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 207 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr His 20 25 30 Asp Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Asp Asp Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Met Ser Leu Ile Glu Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 208 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 208 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Thr 20 25 30 Pro Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Gly Asp Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Tyr Ala Leu Thr Ser Ser Lys Pro Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 209 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 209 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile His Gly Thr Gly Gly Gln Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Leu Ala Asp Arg Ser Gly Gly Val Val Glu Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 210 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 210 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Glu 20 25 30 Thr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Cys Ile Ser Asn Asp Gly Asn Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Glu Ser Leu Ile Ser Pro Gly Leu Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 211 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 211 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Gly Glu 20 25 30 Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Asn Glu Thr Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Ser Thr Arg Gly Val Pro Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 212 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 212 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Met Gly Val Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Asn Gln His Ala His Asp Pro Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 213 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 213 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro Met Gly Thr Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Ala Leu Thr Glu Pro Met Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 214 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 214 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Leu Gly His Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Glu Glu Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 215 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 215 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Pro Arg Tyr 20 25 30 Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Asn Ile Asp Gln Phe Gly Met Lys Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Glu Tyr Ala Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 216 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 216 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Lys Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Met Gly Val Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Arg Gly Asn Thr Ser Asp Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 217 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 217 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Gly Ala Gly His Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Phe Pro Arg Asp Glu Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 218 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 218 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Lys Tyr 20 25 30 Glu Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Glu Ile Gly Leu Asp Gly Ser Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Gly Asp Pro Asn Gly Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 219 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 219 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ser 20 25 30 Glu Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Gly Pro Asp Gly Leu Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys His Ala Asp Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 220 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 220 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Tyr 20 25 30 Asp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Asp Thr Asp Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Leu Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 221 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 221 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Glu Asn Ala 20 25 30 Ser Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Gly Gln Gly Asn Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Ser Ser Trp Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 222 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 222 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Arg Asn 20 25 30 Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Thr Gly Thr Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Asp Pro Gly Asn Arg Tyr Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 223 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 223 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Phe Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 224 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 224 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Phe Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 225 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 225 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 226 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 226 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Gln Val Thr Val Ser Ser 115 <210> 227 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 227 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 228 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 228 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 229 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 229 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 230 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 230 Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 231 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 231 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Phe Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 232 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 232 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Tyr Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Phe Asp Tyr Arg Gly His Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 233 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 233 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Phe Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 234 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 234 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Phe Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 235 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 235 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Lys Phe Asp Tyr Leu Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 236 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 236 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Leu Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 237 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 237 Glu Val Gln Leu Phe Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 238 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 238 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 239 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 239 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Thr Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Glu Phe Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 240 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 240 Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Thr Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Leu Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 241 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 241 Glu Val Gln Leu Leu Val Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Phe Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 242 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 242 Glu Val Gln Leu Leu Val Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 65 70 75 80 Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Phe Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 243 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 243 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 244 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 244 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Trp Gln 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Pro Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 245 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 245 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Trp His 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Ser Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 246 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 246 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp His 20 25 30 Leu Met Ala Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 247 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 247 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 248 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 248 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Trp Gln 20 25 30 Leu Met Ala Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 249 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 249 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp His 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 250 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 250 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Trp Gln 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 251 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 251 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Glu 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 252 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 252 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 253 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 253 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Lys Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 254 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 254 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Lys Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 255 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 255 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 256 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 256 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Lys Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 257 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 257 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ala Lys Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 258 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 258 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Lys Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 259 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 259 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Lys Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 260 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 260 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Arg Asp Ser Lys Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 261 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 261 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Tyr Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 262 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 262 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Arg Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 263 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 263 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Asp Ser Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 264 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 264 Glu Val Gln Leu Leu Glu Phe Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Phe Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Arg Asp Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 265 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 265 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Thr Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 266 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 266 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Glu Ser Ser Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 267 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 267 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Phe Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Ala Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 268 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 268 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Asn Asp Ser Tyr Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 269 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 269 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Ser Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 270 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 270 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Ala Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 271 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 271 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ala Lys Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 272 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 272 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Arg Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 273 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 273 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Lys Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 274 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 274 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Glu 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ala Lys Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 275 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 275 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Glu 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Arg Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 276 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 276 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Glu 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ser Lys Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 277 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 277 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Phe Asp Tyr Leu Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 278 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 278 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 279 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 279 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Gln 20 25 30 Leu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Lys Glu Ser Asn Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 280 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 280 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Trp 20 25 30 Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Glu Ser Gly Leu Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Gly Ala Pro Gln Tyr Gln Ile Thr Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 281 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 281 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Asn Tyr 20 25 30 Gly Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Arg Arg Gly Leu Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Ser His Tyr Met Asn Asn Gly Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 282 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 282 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Asp Tyr 20 25 30 Thr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro Ile Gly Thr Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Pro Tyr Gly Met Glu Asp Gly Leu Thr Trp Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 283 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 283 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Tyr 20 25 30 Asp Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Ser Glu Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Ser Asp Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 284 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 284 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Arg Gly Gly Trp Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Thr Ser Gln Ser Ser Thr Gly Ser Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 285 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 285 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Arg Tyr 20 25 30 Asp Met Leu Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Glu Ile Ser Pro Thr Gly Ala Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Gly Ser Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 286 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 286 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Phe Pro Tyr 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Thr Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Thr Gln Asn Ala Thr Leu Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 287 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 287 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Val Tyr 20 25 30 Thr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Asp Glu Ser Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Val Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 288 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 288 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Phe Tyr 20 25 30 Lys Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Lys Gly His His Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Phe Lys Gly Lys Gly Trp Thr Arg Pro Ser Gly Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 289 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 289 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Glu Tyr 20 25 30 Ser Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Arg Arg Gly Trp Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Val Leu Leu Asp Ser Thr Lys Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 290 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 290 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Tyr 20 25 30 Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Ala Arg Gly Pro Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Arg His Trp Leu Arg Asn Gly Arg Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 291 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 291 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Met Gln 20 25 30 Ser Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Asp Asp Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Arg Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 292 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 292 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ala Ala 20 25 30 Asp Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Thr Asn Asp Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Gly Asp Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 293 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 293 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 20 25 30 Arg Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Ser Ser Gly Glu Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Glu Val Pro Met Gly Asn Gln Thr Phe Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 294 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 294 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser Gln Gly Ala Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Thr Gly Thr Asp Ser Ser Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 295 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 295 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Tyr 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Cys Ile Gly Pro Gly Gly Lys Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Asp Gly His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 296 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 296 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gln Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Ser Arg Gly Trp Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Gly Gly Arg Arg Arg Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 297 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 297 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asp Tyr 20 25 30 Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Met Gly Met Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Ser Ala Ile Ser Phe Thr Ser Asp Ile Ser Asn Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 298 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 298 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Trp Ser Gly Phe Gln Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Val Ala Arg Met Pro Thr Gly Ile Ala Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 299 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 299 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Glu Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Ser Ala Gly Thr Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Gly Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 300 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 300 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Tyr 20 25 30 Pro Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Asp Arg Gln Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Val Arg Arg Gly Leu Pro Arg Pro Ser Arg Tyr Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 301 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 301 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro Met Gly Thr Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Leu Ser Val Tyr Ser Gly Leu Asp Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 302 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 302 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Asp Ile Asp Tyr Ile Gly Lys Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Ser Asp Glu Val Gly Val Asn Thr Ser Lys Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 303 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 303 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Arg Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Thr Gly Val Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Phe Glu Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 304 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 304 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Tyr 20 25 30 Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser His Thr Gly His Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly His Trp Pro Phe Asp Tyr Arg Gly Gln Gly Thr Leu Ile 100 105 110 Thr Val Ser Ser 115 <210> 305 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 305 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Glu 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Asp Ile Ser Pro Gly Gly Trp Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Tyr Arg Pro Phe Asp Glu Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 306 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 306 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Thr Phe Asp Ala Ile 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Arg His Gly Glu Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Asp Ala Trp Ser Arg His Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 307 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 307 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Thr 20 25 30 Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Leu Asp Asn Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Ala Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 308 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 308 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Arg Gln 20 25 30 Ser Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Asp Asp Gly Phe Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Asp Pro Trp Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 309 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 309 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Thr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Asp Gly Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asp Arg His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 310 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 310 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Thr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Ser Asp Asp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Asp Gly Tyr Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 311 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 311 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Gly 20 25 30 Asp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Asn Asp Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Asp Ser Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 312 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 312 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Ala Tyr 20 25 30 Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Pro Asn Gly Thr Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Tyr Val Gly Met Arg Trp Asn Ser Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 313 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 313 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser Leu Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Arg Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 314 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 314 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Glu Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Ser Glu Gly Ser Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Asn Gly Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 315 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 315 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Ser Glu Gly His Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Thr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 316 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 316 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Asp Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Val Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 317 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 317 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Asp Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Thr Gly Gln Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Asn Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 318 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 318 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Asp Tyr 20 25 30 Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Pro Leu Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Glu Val Arg Val Gly Arg Gly Val His Pro Pro Lys Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 319 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 319 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Leu Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Ser Asp Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Gly Val Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 320 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 320 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asn Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ala Pro Leu Gly Val Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Lys Lys Val Gly Ala Trp Leu Gln Ser Arg Ser Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 321 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 321 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Met Asp Tyr 20 25 30 Glu Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Gly Ala Ser Gly His Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Tyr Leu Asp Met Leu Leu Phe Gly Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 322 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 322 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Glu Tyr 20 25 30 Glu Met Met Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Ala Gly Asn Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Met Leu Ser His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 323 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 323 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Asn Tyr 20 25 30 Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Ser Met Gly Leu Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Ser Asn Ala Ser Asp Trp Val Val Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 324 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 324 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Ser Tyr 20 25 30 His Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ala Asp Thr Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Arg Gly Met Ala Arg Val Trp Gly Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 325 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 325 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 20 25 30 Asp Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Ser Ser Ile Ser Asp Arg Gly Leu Gln Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Phe Thr Glu Ile Pro Leu Asp Trp Leu Glu Val Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 326 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 326 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 20 25 30 Lys Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Thr Asn Ser Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Met Tyr Pro Asp Leu Glu Ile Val His Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 327 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 327 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Thr Tyr 20 25 30 Arg Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Asp Gln Glu Gly Ser Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asn Ser Gly Thr Arg Pro Gly Leu Arg Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 328 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 328 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Asp Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Asp Ala Ser Gly Tyr Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gln Leu Leu Lys Leu Ser Leu Asn Pro Asn Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 329 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 329 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile His Asn Thr Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Thr Gln His Arg Phe Val Val Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 330 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 330 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Gly Tyr 20 25 30 Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Leu Gly Pro Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Leu Met Gly Glu Tyr Leu Asn Ser Arg Thr Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 331 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 331 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 20 25 30 Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Asp Ala Asp Gly Trp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gln Thr Gly His Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 332 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 332 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Gly 20 25 30 Glu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Val Asp Pro Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Gly Asp Gln Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 333 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 333 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Glu Tyr 20 25 30 Glu Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Ser Gly Gly His Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Pro Leu Ser Ser Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 334 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 334 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 20 25 30 Val Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Asn Gly Ala Gly Asp Met Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Gly Gly Ala Arg Ser Phe Gly Val Pro Pro Asn Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 335 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 335 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Gly 20 25 30 Glu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Val Asp Pro Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Gly Asp Gln Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 336 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 336 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Thr Leu Tyr 20 25 30 Asn Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Ser Ser Lys Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gln Thr Ser Ser Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 337 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 337 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Tyr 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Val Asn Asn Gly Leu Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Ala Val His Pro Ser Tyr Arg Ala Glu Leu Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 338 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 338 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Glu Pro Asp Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Asp Asn Phe Thr Met Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 339 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 339 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 20 25 30 Met Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Ser Leu Gly His Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Ala Glu Phe Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 340 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 340 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 341 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 341 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val 100 105 110 Thr Val Ser Ser 115 <210> 342 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 342 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 343 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 343 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 344 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 344 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 345 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 345 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Leu Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 346 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 346 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Asp Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 347 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 347 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Lys Arg Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu His Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Ile Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 348 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 348 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Lys Arg Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Arg Ala Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 349 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 349 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Ile Asp Tyr Trp Gly Gln Gly Thr Gln Val 100 105 110 Thr Val Ser Ser 115 <210> 350 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 350 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Gly Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 351 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 351 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 352 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 352 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 353 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 353 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Ile Asp Tyr Arg Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 354 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 354 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Lys Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 355 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 355 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 356 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 356 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 357 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 357 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Met Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 358 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 358 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Phe Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 359 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 359 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Leu Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 360 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 360 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Glu Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 361 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 361 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 20 25 30 Glu Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 362 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 362 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Tyr 20 25 30 Glu Met Met Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 363 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 363 Glu Val Gln Leu Ser Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 364 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 364 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 365 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 365 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Glu Met Asn Ser Met Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Asn Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 366 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 366 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val 100 105 110 Thr Val Ser Ser 115 <210> 367 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 367 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Lys Arg Tyr 20 25 30 Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Phe Thr Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 368 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 368 Glu Val Gln Leu Leu Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Arg Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 369 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 369 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Phe Thr Glu Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 370 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 370 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Tyr 20 25 30 Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro Leu Gly Leu Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Ser Ala Gly Ala Glu Thr His Val Tyr Arg Leu Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 371 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 371 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Val Leu Gly His Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Met Ser Leu Arg Thr Phe Glu Asn Leu Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 372 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 372 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Lys Tyr 20 25 30 Pro Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Asp Ala Asn Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Gly Thr Trp Arg Arg His Phe Ala Ile Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 373 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 373 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Leu Tyr 20 25 30 Asp Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Asp Leu Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asn Gly Phe Arg Val Thr Ser Asn Asp Arg Arg Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 374 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 374 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Gly Gly 20 25 30 Asp Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Met Ile Glu Gly Gly Gly Val Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Leu Asp Leu Arg Thr Gly Gln Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 375 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 375 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Ser Asp Pro Thr Lys Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 376 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 376 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu His Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 85 90 95 Ala Asp Pro Ser Asp Pro Thr Lys Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 377 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 377 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Ser Asp Pro Thr Lys Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 378 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 378 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Ser Asp Pro Thr Lys Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 379 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 379 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Ser Asp Pro Thr Met Phe Val Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 380 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 380 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Ser Asp Pro Thr Met Phe Val Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 381 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 381 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Ser Asp Pro Thr Met Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 382 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 382 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Met Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Met Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Ser Asp Pro Thr Lys Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 383 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 383 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Ser Asp Pro Thr Met Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 384 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 384 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Ser Asp Pro Thr Lys Leu Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 385 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 385 Glu Val Gln Leu Ser Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Thr Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Ser Asp Pro Thr Lys Phe Val Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 386 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 386 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Ser Asp Pro Thr Lys Phe Val Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 387 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 387 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Ser Asp Pro Thr Lys Phe Val Tyr Trp Gly Gln Gly Thr 100 105 110 Pro Val Thr Val Ser Ser 115 <210> 388 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 388 Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 1 5 10 15 Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr Thr 20 25 30 Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 35 40 45 Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Met Leu Tyr Leu 65 70 75 80 Gln Met Lys Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Asp Pro Ser Asp Pro Thr Lys Phe Val Tyr Trp Gly Gln Gly Thr Gln 100 105 110 Val Thr Val Ser Ser 115 <210> 389 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 389 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Phe Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Ser Asp Pro Thr Lys Phe Val Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 390 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 390 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Leu Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Ser Asp Pro Thr Lys Phe Asp Tyr Trp Gly Arg Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 391 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 391 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Ser Asp Pro Thr Lys Phe Val Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 392 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 392 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Thr Trp Thr Tyr Tyr Ala Asp Pro Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asp Pro Ser Asp Pro Thr Lys Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 393 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 393 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Ser Asp Pro Thr Lys Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 394 <211> 118 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 394 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Gly Trp Val Arg Gln Ala Pro Gly Met Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Asp Arg Gly Ser Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Ser Asp Pro Thr Lys Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 395 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 395 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Tyr 20 25 30 Lys Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Glu Ile Gly Asn Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Ala Leu Thr Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 396 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 396 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Ser Tyr 20 25 30 Arg Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Asp Pro Pro Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Leu Asn Leu Ser Phe Pro Tyr Ile Asn Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 397 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 397 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Tyr 20 25 30 Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Ser His Ser Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Gln Leu Asp Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 398 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 398 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr 20 25 30 Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Asn His Asn Gly Ser Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Met Pro Gln Gly Thr Ser Asp Trp Tyr Tyr Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 399 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 399 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 20 25 30 Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Leu Glu Asp Gly Leu Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly Arg Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 400 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 400 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Leu Ser Pro Gly Thr Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Glu Lys Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 401 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 401 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Gly Gly 20 25 30 Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Met Ile Pro Met Asp Gly Ser Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Gly Glu Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 402 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 402 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Glu Tyr 20 25 30 His Met Lys Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Arg Asp Gly Met Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Gln Leu Ala Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 403 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 403 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30 Glu Met Leu Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Leu Pro Ser Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Gly Ser Gly Asn Gly Pro Ile Leu Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 404 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 404 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Glu His 20 25 30 Asp Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Gly Ala Glu Gly Val Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Thr Met Ser Asn Gly Ser Gln Ser Arg Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 405 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 405 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ile Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 406 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 406 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 407 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 407 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 408 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 408 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 409 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 409 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Val Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 410 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 410 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ile Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 411 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 411 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 412 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 412 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Ala Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Leu Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 413 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 413 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Val Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 414 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 414 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ile Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Arg Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 415 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 415 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 416 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 416 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ile Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 417 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 417 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Val Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 418 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 418 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 419 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 419 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 420 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 420 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Asn 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 421 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 421 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Ile Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 35 40 45 Ser Gly Val Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 422 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 422 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ile Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 423 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 423 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 424 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 424 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Thr 20 25 30 Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Glu Asp Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Val Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 425 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 425 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Ala 20 25 30 Glu Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Ser Arg Pro Gly Gln Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 426 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 426 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Gly 20 25 30 Thr Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Leu Pro Ser Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys His Ser Leu Thr Asn Arg Pro Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 427 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 427 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 20 25 30 Asp Met Arg Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Asp Ile Asp Ala Val Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Pro Gly Gly Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 428 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 428 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Met Tyr 20 25 30 Gly Met Met Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Glu Gly Ala Gly His Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Val Leu Gly Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 429 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 429 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Gln Tyr 20 25 30 Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Val Gly Leu Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Phe Glu Gly Ser Arg Ile Gln Arg Asp Val Gly Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 430 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 430 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Lys Tyr 20 25 30 Gln Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Arg Gly Ser Gly Leu Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val His Thr Thr Leu His Thr Glu Val Ile Gly Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 431 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 431 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gln Tyr 20 25 30 Thr Met Tyr Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Glu Ile Ser His Ser Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Ser Gly Leu His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 432 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 432 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Ala Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Gly Val Glu Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Leu Arg Leu Tyr Arg Leu Gly Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 433 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 433 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Lys Tyr 20 25 30 Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Lys Ile Asn Ser Asp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Leu His Gly Arg Gly Phe Val Ile Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 434 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 434 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 20 25 30 Asp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Asn Ser Met Gly Leu Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Tyr Ser Val Ala Pro His Gly Tyr Pro Leu Gly Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 435 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 435 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Asp Tyr 20 25 30 Ser Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Asp Asn Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys His Met Ser Leu Ala Thr Tyr Leu Gln Phe Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 436 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 436 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Met Glu Tyr 20 25 30 Asp Met Leu Trp Val Arg Gln Ala Pro Gly Lys Ala Leu Glu Trp Val 35 40 45 Ser Arg Ile Ser Ser Asp Gly Leu Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Val Ser Ala Leu Ala Pro Phe Asp Ile Gly Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 437 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 437 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Glu Tyr 20 25 30 Asn Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asn Phe Ala Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Ser Leu Pro Leu Asp Ile Phe Ser Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 438 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 438 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser His Ile Ser Ser Asn Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Thr Ser Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 439 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 439 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser His Ile Ser Ser Asn Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 65 70 75 80 Leu Arg Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Thr Ser Gly Tyr Tyr Glu Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 440 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 440 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser His Ile Ser Ser Asn Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Thr Ser Gly Tyr Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 441 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 441 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser His Ile Ser Ser Asn Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Thr Ser Ser Tyr Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 442 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 442 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser His Ile Ser Ser Asn Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Thr Ser Gly Tyr Tyr Glu Tyr Trp Gly His Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 443 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 443 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Gly Asp Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser His Ile Ser Ser Asn Gly Arg Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Thr Ser Gly Tyr Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 444 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 444 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser His Ile Ser Ser Asn Gly Arg Phe Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Thr Ser Gly Tyr Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 445 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 445 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Glu Tyr 20 25 30 Val Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Asn Gly Leu Gly Asn Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Thr Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Glu Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Ile Gln Leu Pro Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 446 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 446 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Asp 20 25 30 Gly Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Phe Ile Asn Val Asp Gly Arg Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Trp Ser Pro Gly Arg Val Gln Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 447 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 447 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Trp 20 25 30 Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ala His Glu Gly Gly Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Tyr Val Pro Gly Ser Pro Leu Phe Asp Tyr Trp Gly Gln Arg 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 448 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 448 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gln Gly 20 25 30 Trp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Gly Ser Asn Gly Pro Arg Thr Ser Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Gly Glu Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 449 <211> 117 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 449 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Gln Ser 20 25 30 Asp Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Ile Gly Asn Asn Gly Glu Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Asn Trp Leu Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 <210> 450 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 450 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Leu Ser 20 25 30 Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Gly Gly Asp Gly Ser His Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Gly Thr Gln Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 451 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 451 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr 20 25 30 Thr Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Val Thr Gly Tyr Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Gly Gln Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 452 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 452 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Asp Pro Leu Gly Arg Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Asp Leu Ser Ser Leu Gln Tyr Gly Val Ser Pro Asn Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 453 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 453 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Phe His Tyr 20 25 30 Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Gly Pro Val Gly Arg Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Met Ile Gln Ser Pro Leu Phe Lys Asp Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 454 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 454 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr 20 25 30 Asp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Arg Ile Asp Ser Gly Gly Asn Gln Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Ala Ser Leu Trp Lys Trp Arg Leu Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 455 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 455 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Tyr 20 25 30 Gly Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Leu Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys His Ala Thr Ser Gln Glu Ser Leu Arg Ser Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 456 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 456 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 20 25 30 Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Leu Pro Asp Ala Phe Trp Thr Arg Gly Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 457 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 457 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Tyr 20 25 30 Ser Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Asp Arg His Gly Leu Ala Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Pro Gly Ser Ser Trp Gln Thr Val Phe Gly Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 458 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 458 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ser Tyr 20 25 30 Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp His His Gly His Ser Thr Tyr Tyr Ala Asp Ser Ala 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Leu Arg Val Ser Met Ile Phe Gly Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 459 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 459 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Gln Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Ser Ser Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Thr Ser Arg Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 460 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 460 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Glu Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Ser Pro Pro Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Val Ile Leu Gly Tyr Thr Asn Arg Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 461 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 461 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Asn Tyr 20 25 30 Gly Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asn Ser Ser Gly Met Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Phe Phe Arg Leu Asn Asp His Asn Ser Val Phe Gly Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 462 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 462 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Asp Tyr 20 25 30 Lys Met Met Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Val Gly Ser Gly Ser Met Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Pro Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 463 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 463 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Asn Tyr 20 25 30 Ala Met Gly Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Glu His Gly Thr Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Ser Leu Asp Arg Val Trp Ile Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 464 <211> 122 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 464 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr 20 25 30 Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Tyr Ser Ala Gly Ser Pro Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Tyr His Arg Glu Pro Ile Leu Phe Gly Phe Asp Tyr Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 465 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 465 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Ser Asp Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Gly His Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 466 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 466 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 20 25 30 Thr Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Glu Ile Asp Arg Thr Gly Glu Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Pro Gly Phe Ala Ser Leu Pro Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 467 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 467 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 20 25 30 Thr Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Lys Ile Ser Pro Ser Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asp Pro Phe Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 468 <211> 119 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 468 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ala 20 25 30 Glu Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Ala Arg Gly Leu Thr Thr Tyr Tyr Ala Asp Pro Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Glu Ala Thr Ser Ala Met Tyr Pro Phe Asp Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 469 <211> 121 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 469 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr 20 25 30 Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Leu Gly His Phe Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ser Gly Phe His Glu Tyr Thr Glu Gly Phe Asp Tyr Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 470 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 470 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Arg Ala 20 25 30 Gly Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Leu Ile Gly Arg Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ile Arg Asn Leu His Trp Asp Val Gly Arg Gln Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 471 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 471 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Arg Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Ser Asp Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Ser Arg Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 472 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 472 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Phe Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Leu Tyr 20 25 30 Pro Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro Val Gly Phe Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly His Glu Gly Ser Tyr Thr Pro Arg Ser Ala Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 473 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 473 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Ala Tyr 20 25 30 Pro Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ala Pro Leu Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Arg Pro Glu Gly Leu Gln Ile Asp Ser Gln Asn Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 474 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 474 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Leu Tyr 20 25 30 Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Asp Ser Ser Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Pro Glu Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 475 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 475 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Gln Tyr 20 25 30 Gln Met Ala Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ala Ser Asp Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Gly Arg Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 476 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 476 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Gln Tyr 20 25 30 Asp Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Trp Ile Asp Glu Ala Gly His Glu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gly Met Asp Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 477 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 477 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Asp Tyr 20 25 30 Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Thr Gly Gly Phe Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Ala Arg Tyr Tyr Tyr Leu Ser Gln Ile Lys Asn Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 478 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 478 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ile Tyr 20 25 30 Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Pro Leu Gly Leu Val Thr Tyr Tyr Ala Asp Pro Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Leu Lys Glu His Gly Asp Val Pro Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 479 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 479 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Leu Tyr 20 25 30 Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Thr Gly Leu Leu Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Phe Lys Arg Ser Gly Lys Thr Asp Asp Thr Asn Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 480 <211> 116 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 480 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Glu Tyr 20 25 30 Asp Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Val Gly Asp Gly Asn Gly Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Gln Asp Arg Gln Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 481 <211> 120 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 481 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Tyr 20 25 30 Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Ser Pro Ile Gly Val Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Asn Ala Tyr Asp Arg Lys Ser Asn Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 482 <211> 124 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 482 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Arg Tyr 20 25 30 Val Met Val Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val 35 40 45 Ser Gly Ile Thr Pro Ser Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asp Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Val Leu Gly Arg His Phe Asp Pro Leu Leu Pro Ser Phe Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 483 <211> 123 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 483 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Thr Ile Thr Pro Gly Gly Phe Trp Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Lys Thr Ser Ser Gly Glu Leu Gln Leu Val Glu Asp Phe Asp Tyr 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 484 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 484 gaggtgcagc tgttggagtc tgggggaggc ttagtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttatt gcttatgata tgagttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatgg attgatgagt ggggtctgca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaagacg 300 cctgaggagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 485 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 485 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt gattatgaga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attgatggtg agggttctga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaccgggg 300 aggagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 486 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 486 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag cgttatccta tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attcatggtt ctggtagtgc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggccg 300 tatactagtc ggcataatag tcttgggcat tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 487 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 487 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttatg gattatccta tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgggcctg ttggtatgag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatatggg 300 gggactagtg gtaggcataa tactaagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 488 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 488 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gagtatccta tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagtt atttctcctc ttggttttac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatggact 300 ggtgggagtg gtattttgaa ttcttctttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 489 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 489 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt tagggttagc aattacgatt tgacctgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtatcaacc attagtgcca caaacggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc ggcagtgacg 300 tggtggttgt tgcgtcataa cgacaacttg gggttttggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 490 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 490 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt tagcattagc tataagaata tggcctgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtatcagcc attaaggcgg caaacggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgcgc gacagggagt 300 cagaagaagc ggacctacac gttcgacttt tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 491 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 491 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagg ttgtatgaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attgatattt tgggttcgag gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatctg 300 tcgtggcagg gttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 492 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 492 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagg tcttatacga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attaatccta tgggttatca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacatggg 300 gtggggaagg gtactaagcc gcataatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 493 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 493 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag ctgtatagga tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagag attagtggta gtggttttcc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtctg 300 catgataaga ctcagcatca tcaggagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 494 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 494 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttatt gagtatccta tgcggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcactt atttctccgt ctggtgtgtt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggat 300 gagtctagta cttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 495 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 495 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag cggtatgata tggattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgggagtt cgggttatcc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaaggatg 300 cctggttatt ttcctgggtt tgctcggcag tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 496 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 496 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttgg cggtatgcta tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attaatgatg agggtcggga gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaagcgg 300 gtgtctagtt ctgtgaatgc tccgtatgag tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 497 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 497 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg aattatagta tgagttgggt ccgccaggcc 120 ccagggaagg gtctagagtg ggtctcatcg attgatcgtc ttggtacgca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa tacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagtgctg 300 gctgatctta ttgctgggca tgcggagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 498 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 498 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttccg tcgtatgata tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg atttcgaggt ctggttctat gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ttgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtgtt 300 gatgcgcatg tttattatat ggagcctttt tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 499 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 499 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag aggtatcaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attagttctg atggtggggg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggt 300 actgtttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 500 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 500 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacatttccg aagtatgaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgatggtg atggtaagtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaccggat 300 cagttttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 501 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 501 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct tattattcga tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg atttcgcctt ttggttgggg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagga cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatggg 300 gagacgagtg gtccgatttc tgagaatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 502 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 502 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cacctttgcg ggttatcaga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attactaatg agggtgtttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggg 300 aagtattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 503 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 503 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gagtatgaga tggtgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct attacgtcgg atggtctgag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgctgaggac accgcggtat attactgtgc gaaaccgggt 300 attcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 504 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 504 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gattatgata tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgttgatg atggtcttat gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccggat 300 gttgcttttg actactgggg tcaggggacc ctggtcaccg tctcgaac 348 <210> 505 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 505 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttatt ggttatgcta tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attggtcctt tgggtgcgac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaattgcct 300 gctggtacga gtagtcatag tgtggatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 506 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 506 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg gattatgaga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attactagtg atggtgtttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgtcg 300 gttcagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 507 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 507 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgt aggtatgtta tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatgg attgaggctg atggtcgtac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggctt 300 acggatcagc atgttattga gtttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 508 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 508 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat ggttatcgta tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attgctccgg atggtaatta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaattttgg 300 gggatgcagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 509 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 509 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct tcgtatccga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attggtccta ttggttttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaatgaag 300 tcgccttata agccgcagtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 510 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 510 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttttg gcttattgga tggtttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct atttctccgt cgggtacgca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgtcgaggac accgcggtat attactgtgc gaaatatact 300 gagccggggt tgggttcttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 511 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 511 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg aattatgaga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagtg atttctgagg tgggttctct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctcat 300 gatagttcga ttgggtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 512 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 512 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttgg tcttatgata tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attatggctt cgggtgatga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatgggat 300 cgggattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 513 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 513 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gagtatgtta tgtcgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaact atttctccta ttggtctgac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaatttcct 300 ttgattattc ttcctgattt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 514 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 514 gaggtgcagc tgttggagtc tgggggaggc ctggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttatg gagtatgcga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaatt atttctccgc ttggtttgtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatcag 300 gattcgtctg atagtcagta tacgaatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 515 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 515 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gattatggga tggggtgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attggtcctc tgggtctttg gacatactac 180 gcagactccg cgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatctccg 300 cttgagggtt tgattacgaa ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 516 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 516 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gcgtatgaga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaatt attgattggg atggtaattc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacctggg 300 gataatgttg gtatttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 517 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 517 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt aattattata tggtgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcg attgatgagt ggggttttgc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacattgg 300 gagtttacgt ctgatacgtc gcgttttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 518 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 518 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gattttgata tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attaatgatc agggttctct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccggat 300 cagttttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 519 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 519 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gcttatgata tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgg attagtcctc agggtcagcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 gggcagtcgc ggattcctat gaggtttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 520 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 520 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct gagtatgata tgacgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatat attagttctg atggttattc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgcat 300 gggagtccgc gggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 521 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 521 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg gattatgaga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attactagtt tgggtgagag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctggt 300 cgtatttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 522 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 522 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct ttttatccta tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatgg attgatgcta cgggtacgag gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaggtaat 300 tatgggagtt cgtatactat gggggttttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 523 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 523 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gagtatccga tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attggtcctt ctggtccgaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatctccg 300 tattttgatg ttattcctag ttattttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 524 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 524 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg gattacggta tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attcagtcgt cgggtttgcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacgggct 300 aattctcgta ggggttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 525 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 525 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct gattatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attactagtc atggtgggtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacctgat 300 aaggattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 526 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 526 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg cattatccga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attggtaggc tgggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgtgct 300 acgcctgtgc cgattaaggg tttgtttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 527 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 527 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggact cacctttggg aggtatgaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attgattcgg atggttgggt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaaccggat 300 tcgttgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 528 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 528 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct agttattcta tggtgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attaatcggg gtggtactcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggttgg 300 aggagggggt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 529 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 529 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg cgttatagga tgtcttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaggg atttcgaggg atggttatcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtatg 300 actgcgtcgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 530 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 530 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcag atgtatccga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaatg attgagccgg ctggtgatct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatcag 300 gagcagcctt ggtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 531 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 531 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cccctttccg cagtatcaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaatg attacttctg atggtcttga tacatattac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacctgag 300 cctctttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 532 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 532 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt atgtatgata tgcattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attttgtctg atggtacgga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatggg 300 gctatgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 533 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 533 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag ttgtatccga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgatgcgg ggggtcatga gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagattgg 300 tgggattatc tgtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 534 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 534 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg cggtatccga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attaatcgtt cgggtatgcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagggcat 300 caggcgccgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 535 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 535 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg gggtatgcta tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attaatgcga atggtattcg gacatactac 180 gccgactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acggcctgcg tgccgaggac accgcggtat attactgtgc gaaagggggg 300 gtttggaggt gggggactgg gcataagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 536 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 536 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag cagtatgata tgcggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttcgcaga atggtactaa gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatcgagg 300 actggtaggt attttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 537 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 537 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg acttatgata tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagg attaattggc agggtgatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggg 300 tttggtcatt atgttgatgg tcttgggttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 538 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 538 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gggtatgaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attactgata tgggtgattc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctggg 300 actgcgtttg actactgggg tccgggaacc ctggtcaccg tctcgagc 348 <210> 539 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 539 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg aagtataaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attactccga agggtcattc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaggccg 300 atgactccgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 540 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 540 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag cggtataata tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attcggccgc ggggtgggaa gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggcgg 300 cgggaggggt atactggttc taagtttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 541 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 541 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag aggtatggta tgacttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaagt atttggccga ggggtcagaa gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggaat 300 agtcggtatg tttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 542 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 542 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct gattatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attacttcgg atggtatttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc ttccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaagtggg 300 aggttttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 543 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 543 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg ggttatcaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attagttcgg agggtcttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaattgggg 300 cgtaggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 544 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 544 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact aattatagta tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attcgtccta atggtactaa gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacggtcg 300 tctgcgcatc ttcagaggtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 545 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 545 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt aattattcga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attggtcgtc atggtgggcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaagggg 300 agtacttatc ctaggtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 546 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 546 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt caccttttcg cattatgaga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attgagcctt ttggtggtgg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagtgtat 300 cctcagggtt cttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 547 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 547 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt aattatacta tggggtgggt ccgtcaggct 120 ccagggaagg gtctagagtg ggtctcatct attcggcctg atggtaagat tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagtttat 300 tcttcgtgtg cgatgtgtac tccgcttttg tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 548 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 548 gaggtgcagc tgttggagtc tggggggggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag cggtattcga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagat attgggccga ggggtttttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagtgggt 300 cgtggtcagc gtgatactag tcagccgttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 549 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 549 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct tcttatcaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attacttcgg gtggtcttag tacgtactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggg 300 aggggttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 550 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 550 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggtgggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct tcttatgaga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg atttcttctg atggtctgtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggg 300 gtgttgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 551 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 551 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctctggatt cacctttgat aagtatttga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaggt attgagcctc tgggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagaggct 300 tcgggggatt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 552 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 552 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccgggtt cacctttact gagtatgaga tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attgataatg tgggtagtag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacctggg 300 aagctttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 553 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 553 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gattatgaga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcg atttctaggc agggttttgc tacatactac 180 gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatctg 300 gagcgggatg attttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 554 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 554 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg aattatgaga tggggtgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagtt atttctgagt ggggttattc tacatactac 180 gcagactccg cgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttgtg 300 ggtgggactc agtatgagtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 555 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 555 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcat aattatgaga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt atttcttcgg gtggttcttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggg 300 gttaagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 556 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 556 gaggtgcagc tgttggagtc cgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg ctgtatgaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attacgggtg atggtatttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaggaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctggg 300 aggaagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 557 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 557 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt aattatcaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attactagtg agggtggttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacactgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggt 300 aagaattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 558 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 558 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gattatcaga tggcgtgggt tcgccaggct 120 ccagggaagg gactagagtg ggtctcaagt attactagtg agggtggttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacagtgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggt 300 aagaatttcg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 559 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 559 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aattatgaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attacgtcgc agggtactag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctgat 300 cgttcttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 560 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 560 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgt agttatgaga tgacttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct attacgtcgg atggtggtac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctgat 300 aagacgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 561 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 561 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat ttgtatgaga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attactagtg atggtgtttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccggat 300 tctccgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 562 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 562 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg cattatgata tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attagtgata atggtaatgg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggg 300 cgtgattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 563 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 563 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt cgttatcaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct atttcttctg atggtggggg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacctggg 300 cgggcgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 564 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 564 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg aggtatcaga tggcttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaact atttctgatg atggtgattc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaactggat 300 aagttgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 565 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 565 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatgatgaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attgatacga cgggtgggca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctggt 300 aaggagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 566 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 566 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gagagtgaga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attcttgatg agggttctgg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctgat 300 aaggattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 567 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 567 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gaggaggaga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcg attactgatg atggtgatga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctaat 300 gcgggtgctt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 568 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 568 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gtgtatgata tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attgttaatg atggttcttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctgat 300 aaggattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 569 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 569 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt aatacggaga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attgcggatg atggttctag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctggt 300 caggcttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 570 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 570 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gagtatcaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttcggatg atggttcttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctgat 300 ctttattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 571 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 571 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gtgtatcaga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcattt attgtgcctg ggggtgattt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaacgtgg 300 ccggagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 572 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 572 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aattatgaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attacgagtg atggtacttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacctaat 300 ccgccgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 573 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 573 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag gcgtatgata tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacag attgggaggg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctcgt 300 cggtatgcta tttttacttt tgatcggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 574 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 574 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag cagtatccga tggtgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttctacta atggtgtgag gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatggacg 300 gatattattt cgtcttcgga gtttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 575 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 575 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttttt aattatgata tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttttt 300 gtgtggtcgg ctgatattga ttttgatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 576 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 576 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg tggtatgata tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacat attgcgagtt ggggtggtaa gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagtgacg 300 gtgaaggatg gggggtatct gatggatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 577 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 577 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gagtatgcta tggcgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaagt attgggcggg atggtgcggt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggaag 300 gcggcgaagg agcggggttc ttggtttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 578 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 578 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcag gcttatcaga tgcagtgggt ccgccaggct 120 ccagggaagg gtcttgagtg ggtctcaact attagtccta atggtctttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggttg 300 agttcttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 579 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 579 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct atgtattcga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt atttcgcctc gtggtgttga gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaactaat 300 tggaatggtg tggatctgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 580 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 580 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct acgtatatga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attaatacga atggtcgtga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggat 300 agtaatatgt cgttttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 581 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 581 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag ggttattcga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attaatgcgt cgggtactct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatggt 300 aataggtctg aggttttttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 582 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 582 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttttt gagtatgaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgcgaatg atggttcgac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctgat 300 cggcagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 583 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 583 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcag gattatttga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagag attaatcagg atggtactgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaagttct 300 ccgtattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 584 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 584 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aattatgcga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attagtcggg atggtcatgt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaactttct 300 tctaaggggg ggacgtttgc tagttctttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 585 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 585 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gctgttccga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcg attacggatg atggtcttcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtcat 300 atttatgggg attattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 586 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 586 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag ctttatagga tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtagtg atggtgatac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaacattgg 300 ttgggtacta cgttgtcttt gagggatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 587 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 587 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttat cgttatacga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacag atttcgccta ggggtaatat tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtggt 300 gtggcggggg cggagtcgcc tgagtatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 588 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 588 gaggtgcagc tgttggagtc tgggggaggt ttggtgcagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttttg ggttattata tgagttggat ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgggccga ttggtggtgg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatctcag 300 aatatttatg gtccttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 589 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 589 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag cagtatgata tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagag attagtcgtg atggtgggcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagagtat 300 ccttattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 590 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 590 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttccg cagtatagta tggtgtgggt ccgccaggct 120 ccagggaagg gtcttgagtg ggtctcaact atttcgcctc tgggttcttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaatgagt 300 aagttgttgc tgtcgaggga gtttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 591 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 591 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct atgtattcga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt atttcgcctc gtggtgttga gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaactaat 300 tggaatggtg tggatctgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 592 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 592 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg cgtcatggta tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attacgccta ctggtaatac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatgct 300 catgatgagg ggtattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 593 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 593 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt ccgtatgaga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attgttggtg atggtctgga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccggat 300 cgggtttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 594 <211> 342 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 594 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt agtacgccta tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagag attagggata cgggtctggc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gagtgtttcg 300 tttgactact ggggtcaggg aaccctggtc accgtctcga gc 342 <210> 595 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 595 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcat ctgggggata tgcattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attagtggga cgggtcatac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacctatg 300 aatgatcagg ggtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 596 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 596 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttatg gatgaggata tgttgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagg attaattcgc tgggtactca tacatactac 180 gcagactccg tgaagggccg attcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatcgttt 300 atgatgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 597 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 597 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgt aattatcaga tgcattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgatgcga ctggtcgggc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gagatctact 300 aggtcatttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 598 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 598 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg aatgcggata tggtgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggttat 300 ttgacttcgc attttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 599 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 599 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagg gattattcta tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attactccgt cgggtcttac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaatggtct 300 caggcggtta ctcggtcttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 600 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 600 gaggtgcagc tgttggagtc tgggggagac ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct gatgagggta tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagag attaatcagc agggttcggc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaacgatt 300 gggatgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 601 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 601 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gatcagccga tggtgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attggggcgc gtggtgggcc tacatactac 180 gcagactccg tgaagggccg gttcaccgtc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggttt 300 gatattattg cttgggatcc ttttagtttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 602 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 602 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat cagtatccta tgatgtgggt tcgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attactcctt ctggtttttt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaatggaat 300 ccttttatta ctacgtttga ctactggggt cagggaaccc tggtgaccgt ctcgagc 357 <210> 603 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 603 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg catcagcaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attactccga atggttatta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatttgat 300 tattcgcttc gttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 604 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 604 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct tcttatgaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attggtagtg atggtgggcc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac tccgcggtat attactgtgc gaaacctgat 300 agggcttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 605 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 605 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct gcggagcaga tgacttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attactccgc atggtgattc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggcgg 300 actttggttg attggcctac gagtgagtcg tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 606 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 606 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg tcttatgaga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgagccta ctggtattac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctcat 300 tttactgagc ttggttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 607 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 607 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag ggggagcaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attacgctgc ctggtccgta tacattctac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggaat 300 gggacgtttt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 608 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 608 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt aattatgcga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaaag attggggcgc agggtcttca tacatactac 180 gcaggctccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacagacg 300 acgatggatt atgagaggtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 609 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 609 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gaggttgata tgtcgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcagct attggtaata atggtcttaa gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatcggct 300 ctgtcgtata ggcctcctgt ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 610 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 610 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcag gatgatacta tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attacgctta agggtccgtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatcgagg 300 gatgggttgt attttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 611 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 611 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct tcgtctccga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attggtcggg atggtagtac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccttcg 300 ccttatcggc ggtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 612 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 612 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gattattcga tggtttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attgtgagtc atggtggtac tacatactac 180 gcagactccg tgaagggccg attcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtaag 300 ggttataatg cgcagtattt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 613 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 613 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg catcagcaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attactccga atggttatta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatttgat 300 tattcgcttc gttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 614 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 614 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat gattatgata tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attagttcgc atggtgatag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtgat 300 gttttttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 615 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 615 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg catcagcaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attactccga atggttatta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaatggtcg 300 gattcttttg actacagggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 616 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 616 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gattatgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attcagtcta atggtaatat tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctaat 300 tctcaggttg agtattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 617 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 617 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gtggagccta tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaaat attggtcgtg atggttcgat gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaattgggg 300 aagcatggta cttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 618 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 618 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttccg gagtatcgga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatgg attgatgagc ggggttcgct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaggcgg 300 aagggtacta agcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 619 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 619 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag ttgtatgcta tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attggtgctg tgggtgagac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagaggct 300 aataatcttt ctgataatct tgtgtttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 620 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 620 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg catcagcaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attactccga atggttatta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggtcg 300 gttgagtggt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 621 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 621 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat agttatacga tgaattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attaatcctt ggggtagtcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaggtctg 300 gtgctgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 622 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 622 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat ggtgatatga tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attactcagc ttggtagtag gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacagaat 300 tggcggactc ttacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 623 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 623 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttaat gcttatggga tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attctttctg atggtgttat tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtgct 300 cggggtgcga atttttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 624 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 624 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg cattatatga tggtgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct attacgcctc atggtacgag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaatttaat 300 gctattttta gtgaggcgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 625 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 625 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagg gattattcta tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attactccgt cgggtcttac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaatggtct 300 caggcggtta ctcggtcttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 626 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 626 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat ctttatgcga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaatg attgggaggg atggtcgttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac acggcggtat attactgtgc gaaattggct 300 ggttcgctga ggggtcgttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 627 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 627 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat aaggctagta tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attacgcctc atggttcgtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacagcgg 300 tggggtgttg agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 628 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 628 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcag gggtatagta tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgctgggc gtggtggtgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtttg 300 tatatttatc atagtctgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 629 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 629 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctgggggctc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct ggtatggaga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attactggga ctggtagtac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggttat 300 catccgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 630 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 630 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttccg atggtggcta tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgctcggg atggtaatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc gaaagtttcg 300 ccgactggtt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 631 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 631 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg catcaggata tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attacggatg atggtgagag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtgat 300 tatgattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 632 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 632 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gagtataata tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacag attacgaggg atggttctag gacatactac 180 gcagactccg tgaggggccg gttcaccatc tcccgcgaca attccaggaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac tccgcggtat attactgtgc gaaactgtcg 300 aatattgggt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 633 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 633 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gattattcta tgatttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attacgccgt atggttctta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaactgat 300 tatttgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 634 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 634 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat acgtatagta tgatgtgggt ccgccaggct 120 ccagggaagg gtcttgagtg ggtctcaact attactcctt atggtagttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatggggt 300 ctggtgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 635 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 635 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgactc 60 tcctgtgcag cctccggatt cacctttact acgggtccta tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagcg attggtattg ggggtgatac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtct attactgtgc gaaattgact 300 ccgtctaatc agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 636 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 636 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag cagtatcaga tgatgtgggt tcgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attactcctt ctggtttttt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaatggaat 300 ccttttatta gtacgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 637 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 637 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct aattatgata tggtttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg atttctgctt tgggtaatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaacga acagcctgcg tgccgaggac actgcggtat attactgtgc gaaatggcgt 300 agtgctatta ctggtaattt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 638 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 638 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag gagtatcaga tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atttcgccgt cgggtatgaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaatggcgg 300 tcggttgttc gtccttggcc gggtgtgttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 639 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 639 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gatgagagta tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attactcctc atggtacttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttcat 300 cttaagttgt atgagtctca ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 640 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 640 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag ggtggtgaga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaatg attccgatgg atggtagtgc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggg 300 agtacgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 641 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 641 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat tttatgccga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgggaggg atggtgctta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttgct 300 tcgccggcgc agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 642 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 642 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt gatgagccta tgctgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgggggta cgggtacgac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtaat 300 cagggtgatt ttattaatcg gtttcactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 643 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 643 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcat gcgtataata tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttctccgc ggggttctta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggccg 300 ccgccttcgt ctcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 644 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 644 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gggtatgaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attacgagtg atggtacgag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggg 300 ctgcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 645 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 645 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag ggttatatga tgtattgggt ccaccaggct 120 ccggggaagg gtctagagtg ggtctcatct atttctcctc agggtcattt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaacttcgt 300 gagcttcctc gtctgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 646 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 646 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt agttatgcta tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attgatgcga gtggtggtcc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgaat 300 gggaagaagt ttccttttac taagtatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 647 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 647 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct agtgtgcata tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attaatctga cgggtgttga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtgct 300 actactaggc aggcgcatcc gttgtatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 648 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 648 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag gagggtgaga tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttcgacta atggtcttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatctact 300 cgtgatctgg gttttgccta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 649 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 649 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gagtatgaga tggcttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcattt atttctcctc gtggtcattt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccggct 300 aagacttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 650 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 650 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat acgtatgaga tgctttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt atttctgttg atggtagtat tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaacgcgg 300 atgcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 651 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 651 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt tcgtatgcta tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaaat atttctcgtg atggttcgaa gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagcgcag 300 tctggggggc ttcggtcggg tttgactacg tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 652 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 652 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag actccggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgggaggg atggtgctta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggg 300 ccgaagggta ttgcgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 653 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 653 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt ccgcatgcta tggcttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaggt attgatgggg ggggttcgat gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatcggat 300 cctccgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 654 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 654 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt cacctttcat gcgggggaga tgcattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attacgctgc ctggtgatat gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgaat 300 actgggtata cttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 655 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 655 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg aattatggta tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt atttcgtggg atggttctct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaaaatacg 300 cggctttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 656 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 656 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcat gatgcggata tgctgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attttgtctc cgggtgagga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatttggt 300 ctgccgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 657 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 657 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgt actgatcaga tgaattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt atttctccta gtggtgcgta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaggtctt 300 ggtgcttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 658 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 658 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt catctttgag cagtatcaga tggtttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatgg atttcgcctg atggtacgca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatttagt 300 ttgcgtaaga tggagaagtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 659 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 659 gaggtgcagc tgttggaatc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcag gatgagcaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attgcgtctg atggtatgtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga atagcctgcg tgccgaggac accgcggtat attactgtgc gcaacctggg 300 aagaattttg accactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 660 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 660 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gattatgcga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attactactg ggggtgagcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgttgg 300 aatctgtata cggagtcttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 661 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 661 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt ggtcagccga tggattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgctcctg atggtattca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaatttg 300 ggtcagggtt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 662 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 662 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag cggtatcaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt atttctccta gtggtacgtt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaatggaag 300 gcgctttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 663 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 663 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct cattcgacta tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcactt attttgccgt cgggtagtcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaattttct 300 gatgagcgtt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 664 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 664 gaggtgcagc tgtcggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt gatgggaata tggattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt atttctagtg atggtgtgac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatagg 300 ggtcaggggt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 665 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 665 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cttccggatt cacctttgat gattatatga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attagtccgc atggtgttta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatggttg 300 catacgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 666 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 666 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg aattatacga tggcgtgggg ccgccaggct 120 ccagggaagg gtctagagtg ggtctcattt attgctggtc cgggtaatta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggg 300 agtactgcga cgtataataa tggtcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 667 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 667 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg gagtatagta tggtgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct attagtggga gtggtcgtgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggctt 300 aagctggtta gggctcctaa tccgtttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 668 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 668 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt aattatcaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt atttctaaga ctggtcattc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaggaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcttcg 300 cattcgttgg ggcctctttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 669 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 669 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg gcgtatagga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatgg atttcgcctt ctggttcggg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaactttg 300 acggattcgc cgtcggggca ttatgagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 670 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 670 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg cggtatgaga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgg attactgctc agggtcttgg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca actccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatatctt 300 actgatttta gtagtgggca tcaggagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 671 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 671 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gattatggta tgtcgtgggt ccgccaggtt 120 ccagggaagg gtctggagtg ggtctcaggt attagtcata atggtatgtt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatattgg 300 ccgtctacta gttgggagac tgattttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 672 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 672 gaggtgcagc tgttggagtc tgggggaggc tcggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg aatgagccta tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attgagatgc agggtaagaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatagg 300 ggtcaggggt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 673 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 673 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gaggaggaga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatgt attgataatc tgggtagtcc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc gaaaacgatt 300 tctcatcagt atgataggtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 674 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 674 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gaggaggaga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attgatgagg ggggtcggtg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggacg 300 ccgcataagc agttgtcgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 675 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 675 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cagctttgct gatgagtata tggtttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagag attgatccgt tgggtactgg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatggg 300 acggcttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 676 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 676 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc 60 tcctgtgcag cctccggatt caccttttct acgcatgata tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg atttctgatg atggtattag tacatactac 180 gcagactccg tgaagggccg gttcaccatt tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacctgat 300 atgtctctta ttgagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 677 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 677 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat ggtactccga tggtttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attagtggtg atggtaggaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaccttat 300 gcgcttactt cgtctaagcc ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 678 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 678 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat gattatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatgg attcatggga ctggtggtca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctttg 300 gctgatagga gtgggggggt tgttgagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 679 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 679 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gcggagacga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatgt attagtaatg atggtaatac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagtct 300 ctgattagtc ctggtctttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 680 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 680 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact ggtgagtata tgaattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attaatgaga ctggttatat gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga atagcctgcg tgccgaggac accgcggtat attactgtgc gaaactttct 300 acgagggggg tgccttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 681 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 681 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagg tcgtatgata tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttcgccta tgggtgtttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatctaat 300 cagcatgctc atgatccttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 682 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 682 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gattatgata tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaagt atttcgccta tgggtacgtt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctgct 300 ttgactgagc ctatgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 683 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 683 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgt gattatgata tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atttctcctc ttggtcattt tacatactac 180 gcagactccg tgaagggccg gtccaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagctgag 300 gaggcttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 684 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 684 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc 60 tcctgtgcag cctccggatt cgcctttcct aggtatggta tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaaat attgatcagt ttggtatgaa gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagagtat 300 gcttcgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 685 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 685 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aagtatgata tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttcgccta tgggtgtttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcgg 300 ggtaatactt cggattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 686 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 686 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt aattatgata tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atttctgggg cgggtcattt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtttt 300 ccgcgtgatg agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 687 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 687 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttccg aagtatgaga tgaggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagag attggtctgg atggttcgcc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaattgggg 300 gatccgaatg gttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 688 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 688 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttccg actagtgaga tggattgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaggt attgggcctg atggtttgac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacatgcg 300 gattggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 689 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 689 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct gagtatgata tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatgg attgatactg atggtgggga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctggt 300 ctgaagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 690 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 690 gaggtgcagc tgttggagtc tgggggaggc ctggtacagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cacctttgag aatgcttcta tgcagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgaggggc agggtaatgc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagttcg 300 tcttggtctt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 691 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 691 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg cgtaatgaga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attacgccga ctggtacgtt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaacggat 300 cctggtaata ggtattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 692 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 692 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attttgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 693 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 693 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttggtt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attttgacta ccggggtcag gggaccctgg tcaccgtctc gagc 354 <210> 694 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 694 gaggtgcagc tgttggagtc tggtggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccgtc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 695 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 695 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctcaggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagattccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaacccagg tcaccgtctc gagc 354 <210> 696 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 696 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 697 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 697 gaggtgcagt tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaaggaccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgctaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagtaggg 300 aaggagagta attttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 698 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 698 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggc attgagggtc ctggtgatgt tacatactac 180 gcagactcag tgaagggccg gttcaccatc tcccgcgaca ataccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 699 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 699 gaggtgcggc tattggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caactttaat tggcagctga tgggttggat ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcagtat attactgtgc gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 700 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 700 gaggtgcagc tgttggagtc tgggggaggc ttggtacggc ctggggggtc actgcgtctc 60 tcctgtgtag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attttgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 701 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 701 gaggtgcagc tgttggagtc tgggggaggc ttggtacaga ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctataat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgatgac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attttgacta ccggggtcac ggaaccctgg tcaccgtctc gagc 354 <210> 702 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 702 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgcaaggct 120 cctgggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attttgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 703 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 703 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggcc 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca ataccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attttgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 704 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 704 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtcttgagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta agtttgacta cctgggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 705 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 705 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagaatccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta atcttgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 706 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 706 gaggtgcagc tgtttgagtc tgggggaggc tcggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attctgacta ccggggtcag gggaccctgg tcaccgtctc gagc 354 <210> 707 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 707 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 acctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcgggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcatcatc tcccgcgaca attccaagaa cacgctatat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 708 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 708 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcggactccg tgaagggccg gttcaccatc tcccgcgaca attccacgaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagtg aatttgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 709 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 709 gaggtgcggc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc acccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta atcttgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 710 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 710 gaggtgcagc tgttggtgtc tgggggaggc ctggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attttgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 711 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 711 gaggtgcagc tgttggtgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa catgctgtat 240 ctgcaaatga acggcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attttgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 712 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 712 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 713 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 713 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag tggcagctca tggggtgggc ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagaccccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 714 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 714 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag tggcacctga tggggtgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta gttctgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 715 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 715 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaac tggcacctga tggcctgggc ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 716 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 716 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag tggcagctga tgggctgggt ccggcaggct 120 ccagggaagg gtctcgagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 717 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 717 gaggtgcagc tgttggagtc tgggggaggc ttggtgcagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag tggcagctga tggcctgggc ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatat tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 718 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 718 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaac tggcacttga tgggctgggc ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 719 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 719 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag tggcagctca tggggtgggc ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 720 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 720 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaac tgggagctga tgggctgggc ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 721 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 721 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaac tggcagctca tgggctgggc ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 722 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 722 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtgggc 300 aaggacagca agtccgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 723 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 723 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcgggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtcggg 300 aaggacagca agtcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 724 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 724 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtcggg 300 aaggacagca actcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 725 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 725 gaggtgcagc tgttggagtc tgggggaggc ttggcacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtgggc 300 aaggacagca agtccgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 726 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 726 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgt gaaagtgggg 300 aaggacgcca agtcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 727 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 727 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggcc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgt gaaagtgggg 300 aaggacaaga actcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 728 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 728 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgt gaaagtgggg 300 aaggagagca agtccgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 729 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 729 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgt gaaagtgggg 300 agggacagca agtcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 730 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 730 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcggactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgt gaaagtcggg 300 aagtacagca actcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 731 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 731 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtgggc 300 aaggacagca ggtcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 732 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 732 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtgggg 300 aaggacgaca gctcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 733 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 733 gaggtgcagc tgttggagtt tgggggaggc ttggtacagc ctggggggtc cttgcgtttt 60 tcctgtgcag cttccggatt cacctttaat tggcagctga tgggttggtt ccggcaggct 120 ccagggaagg gtttagagtg ggtttcaggt attgagggtc caggtgatgt tacatattac 180 gcagattccg tgaagggccg gttcaccatt tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcttgcg tgccgaggat accgcggtat attactgtgt gaaagtgggg 300 agggacagca attccgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 734 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 734 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtgggg 300 aaggacagca cctcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 735 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 735 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtgggg 300 aaggagagca gctcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 736 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 736 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc ttccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgt gaaagtgggc 300 aaggacagcg cgtccgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 737 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 737 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgt gaaagtcggc 300 aacgacagct actcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 738 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 738 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctctggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acggcctgcg tgccgaggac accgcggtat attactgtgt gaaagtgggg 300 aaggacagca gctcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 739 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 739 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcgatat attactgtgt gaaagtgggc 300 aaggacagcg cgtcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 740 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 740 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag tggcagctga tgggctgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgt gaaagtgggg 300 aaggacgcca agtcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 741 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 741 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag tggcagctga tgggctgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtgggc 300 aaggacagca ggtcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 742 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 742 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag tggcagctga tgggctgggt ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtgggc 300 aaggacagca agtccgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 743 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 743 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaac tgggagctga tgggctgggc ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgt gaaagtgggg 300 aaggacgcca agtcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 744 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 744 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaac tgggagctga tgggctgggc ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtgggc 300 aaggacagca ggtcggacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 745 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 745 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaac tgggagctga tgggctgggc ccggcaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc caggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaagtgggc 300 aaggacagca agtccgacta ccggggtcag ggaaccctgg tcaccgtatc gagc 354 <210> 746 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 746 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggatgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggtcg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctacaaatga acagcctgcg tgccgaggac tccgcggtat attactgtgc gaaagttggg 300 aaggagagta attttgacta cctgggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 747 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 747 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgtag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggcg 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagtcggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtttc gagc 354 <210> 748 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 748 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat tggcagctga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgagggtc ctggtgatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300 aaggagagta attctgacta ccggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 749 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 749 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gggtgggaga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgatgagt ctggtcttaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaggtgcg 300 ccgcagtatc agattacatt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 750 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 750 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct aattatggga tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatat atttcgcgga ggggtttgtt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaacgtcg 300 cattatatga ataatgggtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 751 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 751 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgtg gattatacga tggcttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct attagtccga ttggtacttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatcct 300 tatgggatgg aggatggtct gacgtggttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 752 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 752 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gcgtatgata tgcagtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaacg attacgtcgg agggtctttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacctagt 300 gatttgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 753 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 753 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gggtatgata tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atttctcgtg ggggttggtt cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggacg 300 agtcagtcgt ctacggggag ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 754 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 754 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgt cggtatgata tgctttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagag atttcgccta cgggtgctct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttggt 300 tcgacttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 755 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 755 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttttt ccgtattata tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct atttcgggta cgggtgggct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaacgacg 300 cagaatgcga cgctttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 756 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 756 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gtttatacta tggcgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaacg attgatgagt ctggtcgtga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctggt 300 gtttggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 757 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 757 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg ttttataaga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attactccta agggtcatca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttttt 300 aagggtaagg gttggactcg tccgagtggg tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 758 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 758 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat gagtatagta tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgggaggc gtggttggct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctgtg 300 ctgctggatt ctactaagtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 759 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 759 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gagtatccga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atttctgcgc gtggtccttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtagg 300 cattggcttc gtaatggtcg ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 760 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 760 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt atgcagtcga tgcagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attactgatg atggtactag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctgat 300 cgggtttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 761 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 761 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gcggctgata tgcagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcactg attactaatg atggtatttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggt 300 gatcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 762 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 762 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat aagtatagga tgcagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attgatagtt ctggtgagct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagaggtt 300 ccgatgggga atcagacttt ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 763 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 763 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact gattatacta tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attacgtctc agggtgcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctacg 300 ggtacggatt cgtcgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 764 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 764 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gattatgaga tgtcttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatgt attgggccgg ggggtaagcc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagtggat 300 gggcattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 765 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 765 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt cagtatgata tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttcttcga ggggttggct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtccg 300 gggggtcgtc ggcggtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 766 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 766 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttctg gattatgcga tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaact atttctccga tgggtatggg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatcgagt 300 gctatttcgt ttacttctga tatttctaat tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 767 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 767 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gattatccga tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt atttcttggt ctggttttca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacctggt 300 gttgcgagga tgcctactgg gattgctttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 768 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 768 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gcttatgaga tgcagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgatagtg ctggtacttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtct attactgtgc ggaacctttt 300 gggatgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 769 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 769 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gagtatccga tgaagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgatcggc agggtgatcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaacggtg 300 cggaggggtc ttcctcgtcc gagtcgttat tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 770 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 770 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gattatgata tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaagt atttcgccta tgggtacgtt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtctg 300 agtgtgtatt cgggtcttga ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 771 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 771 gaggtgcagc tgttggagtc tgggggaggc ctggtacagc ctggggggtc cctgcgtctc 60 tcctgcgcag cctccggatt caccttttct cattatgata tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcagat attgattata ttggtaagac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tctcgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcttcg 300 gatgaggtgg gtgttaatac ttccaagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 772 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 772 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg cggtatgata tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atttctccta ctggtgtgtt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtttt 300 gaggattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 773 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 773 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gcttatccga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcactg atttctcata cgggtcatgc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcat 300 tggccttttg actaccgggg tcagggaacc ctgatcaccg tctcgagc 348 <210> 774 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 774 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc caggggggtc cctgcgcctc 60 tcctgtgcag cctccggatt cacctttgag gatgagtgga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagat attagcccgg gtggttggac tacatactac 180 gccgactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggttat 300 cgtccgtttg atgagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 775 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 775 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggagt cacctttgat gctattgaga tgtcttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatcg atttcgcgtc atggtgagta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagatgct 300 tggtctcggc attttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 776 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 776 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat agtacggata tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attttggata atggtagtaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa catgctgtat 240 ctgcaaatga atagcctgcg tgccgaggat accgcggtat attactgtgc gaaaggggcg 300 agggattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 777 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 777 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cttccggatt cacctttggt aggcagagta tgcagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attgatgatg atggtttttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggat 300 ccgtggggtt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 778 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 778 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtacag cctccggatt cacctttagt gatacgcaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgatgatg ggggtgtgag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccggat 300 cgtcattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 779 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 779 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg agtacgacga tggggtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcagtg atttcggatg atggtggttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaggaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttgat 300 ggttatggtg tttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 780 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 780 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg agtggggata tgaattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attacgaatg atggtacgtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa tacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatctgat 300 tctgattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 781 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 781 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gcttatgcta tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatat attagtccga atggtacggc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaatatgtg 300 gggatgcgtt ggaattcttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 782 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 782 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg agttatgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attacgagtc ttggtacttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggt 300 aggaagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 783 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 783 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat gagtatgaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attactagtg agggtagtgg gacatactac 180 gcagactccg taaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctaat 300 ggtaagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 784 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 784 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct gattatgaga tgttgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaact attactagtg agggtcattc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctggg 300 acttcgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 785 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 785 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt gattatgaga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgattctg atggtagttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggt 300 gtgaagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 786 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 786 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag gattatgaga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct atttcttcta ctggtcagtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggt 300 aataagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 787 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 787 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttctt gattatggta tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct atttcgcctc ttggtcttag tacatactac 180 gcagactccg tgaagagccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaggtg 300 agggtgggta ggggtgttca tcctccgaag tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 788 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 788 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat ttgtatgaga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attactagtg atggtgtttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctggg 300 gtgatttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 789 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 789 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag aattatgcta tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgctccgc tgggtgttcc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaagaag 300 gttggggcgt ggctgcagtc gcggagtttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 790 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 790 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttatg gattatgaga tgcattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attggtgctt ctggtcatta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatctt 300 gatatgctgc tgtttgggtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 791 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 791 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gagtatgaga tgatgtgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attgctggta atggttctcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gataatgctt 300 tctcattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 792 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 792 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttat aattatgata tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgattcga tgggtcttgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagggtct 300 aatgcgagtg attgggttgt ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 793 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 793 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg tcgtatcata tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attgcggata cgggtgatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac actgcggtat attactgtgc gaaattgcgt 300 gggatggctc gggtttgggg gtttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 794 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 794 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt tattatgata tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg gatctcatct atttcggatc gtggtcttca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatttacg 300 gagattccgt tggattggtt ggaggtgttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 795 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 795 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg agttataaga tgttgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attactaatt ctggtactga gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatcgatg 300 tatccggatt tggagattgt gcattttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 796 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 796 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag acttatcgta tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attgatcagg agggttctgc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaatagt 300 gggacgaggc cggggcttcg gtttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 797 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 797 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc 60 tcctgtgcag cctccggatt cacctttagt agttatgata tgctttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgg attgatgcga gtggttattt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaattgttg 300 aagctgtcgt tgaatcctaa ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 798 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 798 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attcataata ctggtttgtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggact 300 cagcatcgtt ttgttgtttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 799 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 799 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag ggttatccta tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attagtcctt tgggtcctga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaactgttg 300 atgggggagt atttgaattc taggacgttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 800 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 800 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat acgtatagta tgtcttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatgg attgatgctg atggttgggt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaaactggg 300 catacgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 801 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 801 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg gatggggaga tgggttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagg attgtggatc ctggtgattc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggt 300 gatcagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 802 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 802 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct gagtatgaga tgaagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attactccgt cgggtggtca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc gatacctctt 300 tctagttttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348 <210> 803 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 803 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct aattatgtga tgatttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcactt attaatggtg ctggtgatat gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagggggt 300 gcgcgttcgt ttggggttcc gcctaatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 804 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 804 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg gatggggaga tgggttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagg attgtggatc ctggtgattc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggt 300 gatcagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 805 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 805 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgtag cctccggatt cacctttacg ctgtataata tgtcttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcagtt atttctagta agggtgatag tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaaacgagt 300 agtgtttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 806 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 806 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gcgtattata tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgttaata atggtttgtt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa catgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatcggct 300 gttcatcctt cgtatagggc ggagttgttc gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 807 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 807 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt tcgtatgaga tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attgagcctg atggtagtaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtccg 300 gataatttta ctatgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 808 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 808 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaat aagtatatga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgatagtc ttggtcatta tacatactac 180 gcagactctg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagcggag 300 tttccgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 809 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 809 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 810 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 810 gaggtgcagc tgttggagtc tgggggaggc atggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actactgggg tcagggaacc caggtcaccg tctcgagc 348 <210> 811 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 811 gaggtgcagc tgttggagtc tgggggaggc atggtgcagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 812 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 812 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgcaaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccgagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggatccgttt 300 actgagtttg actattgggg tcagggtacc ctggtcaccg tctcgagc 348 <210> 813 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 813 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccgtc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggacccgttt 300 actgagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 814 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 814 gaggtgcagc tgttggagtc ggggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcgtgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca ataccaagaa cacgctgtat 240 ctacagatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggacccgttt 300 actgagcttg actactgggg tcatggaacc ctggtcaccg tctcgagc 348 <210> 815 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 815 gaggtgcagc tgttggagtc tgggggaggc ttggtacggc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat atttctgtgc agatccgttt 300 actgagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 816 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 816 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cgcctttaag aggtatgaga tgacatgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcatatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggatccgttt 300 actgagattg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 817 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 817 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cccctttaag aggtatgaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actaccgggc tcagggaacc ctggtcaccg tctcgagc 348 <210> 818 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 818 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcttct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggatccgttt 300 actgagattg actactgggg tcagggaacc caggtcaccg tctcgagc 348 <210> 819 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 819 gaggtgcagc tgttggagtc tgggggaggc ttggtacatc ctggggggtc cctgcgtctc 60 tcctgtgcag cttccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgacgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actacggggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 820 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 820 gaggtgcagc tgttggagtc tgggggaggc tgggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctcaggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggatccgttt 300 actgagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 821 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 821 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actactgggg tcatggaacc ctggtcaccg tctcgagc 348 <210> 822 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 822 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cactctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagattg actaccgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 823 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 823 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aagtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actactgggg tcatggaacc ctggtcaccg tctcgagc 348 <210> 824 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 824 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaac agctatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actactgggg tcatggaacc ctggtcaccg tctcgagc 348 <210> 825 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 825 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggatccattt 300 actgagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 826 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 826 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggacccgttc 300 acggagatgg actactgggg tcatggaacc ctggtcaccg tctcgagc 348 <210> 827 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 827 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggacccgttc 300 acggagttcg actactgggg tcatggaacc ctggtcaccg tctcgagc 348 <210> 828 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 828 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtcta 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggagccgttc 300 acggagttgg actactgggg tcatggaacc ctggtcaccg tctcgagc 348 <210> 829 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 829 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggcc 120 ccagggaagg gtctggagtg ggtctcatcg atttcgtccg acggttcctt cacgtactac 180 gccgagtcgg tcaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actactgggg tcatggaacc ctggtcaccg tctcgagc 348 <210> 830 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 830 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaac acgtatgaga tgcagtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actactgggg tcatggaacc ctggtcaccg tctcgagc 348 <210> 831 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 831 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaac aagtatgaga tgatgtgggc ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaggaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actactgggg tcatggaacc ctggtcaccg tctcgagc 348 <210> 832 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 832 gaggtgcagc tgtcggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa tacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggatccgttt 300 actgagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 833 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 833 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccagact 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaaggggcg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcagtat attactgtgc ggaaccgttt 300 actgagtttg actactgggg tcagggaacc ctggtcaccg tctcaagc 348 <210> 834 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 834 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctggaaatga acagcatgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg acaactgggg tcagggaacc ctcgtcaccg tctcgagc 348 <210> 835 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 835 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc agaaccgttt 300 actgagtttg actactgggg tcagggaacc caggtcaccg tctcgagc 348 <210> 836 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 836 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caactttaag aggtatgaga tgacgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc agacccgttt 300 actgagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 837 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 837 gaggtgcagc tgttggagtc tgggggagac ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcacgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actacagggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 838 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 838 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtatgaga tgtcgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatct atttcgtcgg atggttcttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaccgttt 300 actgagtttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348 <210> 839 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 839 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gcgtatccta tgtcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt atttcccctc ttggtttgtg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttagt 300 gctggggcgg agactcatgt ttatcggctt tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 840 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 840 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt aattatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attggggtgt tgggtcatac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttatg 300 tcgttgagga cgtttgagaa tctttttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 841 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 841 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg aagtatccta tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attgatgcta atggtaatag gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagggact 300 tggcgtaggc attttgcgat ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 842 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 842 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat ctgtatgata tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct atttctgatc tgggtacgct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaatggt 300 tttagggtta cgagtaatga tcgtaggttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 843 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 843 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttact ggtggggata tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaatg attgagggtg gtggtgtgac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaacttgat 300 cttcggacgg gtcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 844 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 844 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaccgtcg 300 gatcctacta agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 845 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 845 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcatctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat atttctgtgc ggatccgtcg 300 gatcctacta agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 846 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 846 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggatccgtcg 300 gatcctacta agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 847 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 847 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga gcagcctgcg tgccgaggac accgcggtat attactgtgc ggatccgtcg 300 gatcctacta agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 848 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 848 gaggtgcagc tgttggagtc tgggggtggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttcccg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgtcgaggac accgcggtat attactgtgc ggaaccgtcg 300 gatcctacta tgtttgtcta ctggggtcag ggaacccttg tcaccgtctc gagc 354 <210> 849 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 849 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggctgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctctctt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaccgtcg 300 gatcctacta tgtttgtcta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 850 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 850 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag catccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggatccgtca 300 gatcctacta tgtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 851 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 851 gaggtgcagc tgttggagtc tggggggggc atggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcatgcg tgccgaggac accgcggtat attactgtgc ggatccgtcg 300 gatcctacta agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 852 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 852 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtcacactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaccgtcg 300 gatcctacta tgtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 853 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 853 gaggtgcagc tgttggagtc tgggggaggc ttggtgcagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacactgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgcgc ggaaccgtcg 300 gatcctacta agttagacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 854 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 854 gaggtgcagc tgtcggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 acctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggatccgtcg 300 gatcctacta agtttgtcta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 855 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 855 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc agatccgtcg 300 gatcctacta agtttgtcta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 856 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 856 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgcgc ggaaccgtcg 300 gatcctacta agtttgtcta ctggggtcag ggaaccccgg tcaccgtctc gagc 354 <210> 857 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 857 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcgctt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaggaa catgctgtat 240 ctgcaaatga aaagcctgcg tgccgaggac accgcggtat attactgcgc ggatccgtcg 300 gatcctacta agtttgtcta ctggggtcaa ggaacccagg tcaccgtctc gagc 354 <210> 858 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 858 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc ttccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggatccgtcg 300 gatcctacta agtttgtcta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 859 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 859 gaggtgcagc tgttggagtc tgggggaggc ttgttacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gattatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaccgtcg 300 gatcctacta agttcgacta ctggggtcgg ggaaccctgg tcaccgtctc gagc 354 <210> 860 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 860 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcacgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaccgtcc 300 gatcctacta agtttgtcta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 861 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 861 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggtacttg gacatattac 180 gcagaccccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacactgtat 240 ctgcaaatga acagcctgcg tgccgaggac actgcggtat attattgtgc ggatccgtcg 300 gatcctacta agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 862 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 862 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccgtc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaccgtcg 300 gatcctacta agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 863 <211> 354 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 863 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcttatacta tgggttgggt ccgccaggct 120 ccagggatgg gtctggagtg ggtctcactt attggggatc gtggttcttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaccgtcg 300 gatcctacta agtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354 <210> 864 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 864 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ccggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aattataaga tgtattgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaagt atttcggaga taggtaatct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gatagctctg 300 acgcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 865 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 865 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg agttatcgta tgtattgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatat attgatccgc cgggtagtcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtttg 300 aatttgtcgt ttccttatat taattttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 866 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 866 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag cggtatgaga tgctgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt atttctcatt cgggtcggac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaattggat 300 ggtccgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 867 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 867 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag aggtattata tggattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagg attaatcata atggttctgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaatgccg 300 cagggtactt ctgattggta ttattttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 868 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 868 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttct aagtatgata tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attctggagg atggtctgac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggg 300 cgtttgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 869 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 869 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gattatccta tgacgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaact attctgtctc cgggtacgga gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctgag 300 aaggattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 870 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 870 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag ggtggtgaga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaatg attccgatgg atggtagtgc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggt 300 gaggtgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 871 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 871 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagg gagtatcata tgaagtgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attagtaggg atggtatgaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gatacagctt 300 gctttgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 872 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 872 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc 60 tcctgtgcag cctccggatt cacctttcgt gattatgaga tgctttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attcttccgt cgggtggggc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctggt 300 tcggggaatg ggcctattct ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 873 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 873 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag gagcatgata tgttttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attggggctg agggtgtttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaccgacg 300 atgtctaatg gttctcagtc gcgttttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 874 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 874 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attattgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 875 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 875 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtttcaggt attactgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 876 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 876 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc ccttcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attactgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acaacctgcg tgccgaagac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 877 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 877 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttggat ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attactgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca atttcaagaa cacgctgtat 240 ctgcagatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 878 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 878 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attactgagg atggtaatcg tacatactac 180 gcagattccg tgaagggccg gttcaccatc tcccgcgaca attccatgaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gtctactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 879 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 879 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cttgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aacactgaga tggcttggat ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attattgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 880 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 880 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccgggtt cacctttgat aatactgaga tggcttggat ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attactgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgctgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 881 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 881 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc caggggggtc cctgcgtctc 60 tcctgtgcag cctctggatt cacctttgat aatactgaga tggcttggat ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attactgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cgcgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtctgggaac cctggtcacc 360 gtctcgagc 369 <210> 882 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 882 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attactgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca ataccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gtctactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 883 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 883 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcctggat ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attattgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa caggctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggcac cctggtcacc 360 gtttcgagc 369 <210> 884 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 884 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attactgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat atcactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctcgtcacc 360 gtctcgagc 369 <210> 885 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 885 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctgaggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attattgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 886 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 886 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attagtgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgcagaggac tccgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gtctactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 887 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 887 gaggtgcagc tgttggagtc tgggggaggc ttggtagagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 cctgggaagg gtctcgagtg ggtctcaggt attactgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga gcagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 888 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 888 gaggtgcagc tgttggagtc tgggggaggc ctggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attagtgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat atcactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 889 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 889 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attactgagg atggtaatcg tacatactac 180 gctgactccg tgaagggccg gttcatcatc tcccgcgaca attccaagaa cacgctgaat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 890 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 890 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttggat ccgccaggct 120 ccagggaggg gtctagagtg ggtctcaggt gttactgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcaattt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 891 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 891 gaggtgcagc tgttggagtc agggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgaag cctccggatt cacctttgat aatactgaga tggcttggat ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attattgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca ataccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attattgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagt 369 <210> 892 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 892 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttggat ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attactgagg atggtgatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagag ctcgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctccagc 369 <210> 893 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 893 gaggtgcagc tgttggagtc tgggggaggc tcggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat aatactgaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt attactgagg atggtaatcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cactctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gtctactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 894 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 894 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg tcggctgaga tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggt atttcgaggc ctggtcaggt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 895 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 895 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gatggtacta tggggtgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcactt attttgccgt cgggtagtcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacattcg 300 ctgactaatc gtccgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 896 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 896 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt aagtatgata tgcggtgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagat attgatgctg ttggtactcg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gataccgggg 300 gggacgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 897 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 897 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag atgtatggta tgatgtgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgagggtg cgggtcatgc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac actgcggtat attactgtgc gatagtgctt 300 ggtatgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 898 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 898 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctcgggatt cacctttttg cagtatccga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atttctcctg ttggtttgac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaattgttt 300 gaggggtcga ggattcagcg tgatgtgggt tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 899 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 899 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag aagtatcaga tgggttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attcgggggt ctggtcttgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagtgcat 300 actacgctgc atacggaggt gattgggttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 900 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 900 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc cgggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt cagtatacga tgtattgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagag atttctcata gtggttctaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gatatcgggg 300 ctgcattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 901 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 901 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gattatgcga tggcttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcacgt attggtgtgg agggtgggga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaattgttg 300 cggctttatc gtctggggtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 902 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 902 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct aagtatgata tgacgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaaag attaattctg atggtggtct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggttg 300 catggtaggg ggtttgttat ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 903 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 903 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg cggtatgata tggtgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgg attaattcta tgggtctggc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagattat 300 tcggttgcgc cgcatgggta tcctttgggt tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 904 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 904 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag gattattcga tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attactgata atggtacgtc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacatatg 300 tcgcttgcta cttatctgca gttttttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 905 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 905 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttatg gagtatgata tgctttgggt ccgccaggct 120 ccagggaagg ctctagagtg ggtctcacgt atttcgtcgg atggtctttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggtg 300 agtgcgcttg ctccttttga tattggtttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 906 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 906 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag gagtataata tggcttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaagt attaattttg ctggtcggac gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaactgtct 300 cttcctttgg atattttttc ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 907 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 907 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt gattatggta tgaattgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcacat atttcttcta atggtcgttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaactagt 300 ggttattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 908 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 908 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt gattatggta tgaattgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcacat atttcttcta atggtcgttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa catgctgtat 240 ctgcgaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaactagt 300 ggttattatg aatactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 909 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 909 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc 60 tcctgtgcag cctccggatt cacctttggt gattatggta tgaattgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcacat atttcttcta atggtcgttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaactagt 300 ggttattttg aatactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 910 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 910 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt gattatggta tgaattgggt ccgccaggcc 120 ccagggaagg gtctggagtg ggtctcacat atttcttcta atggtcgttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaactagt 300 agttattttg aatactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 911 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 911 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccgggtt cacctttggt gattatggta tgaattgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcacat atttcttcta atggtcgttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgttt 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaactagt 300 ggttattatg agtactgggg tcatggaacc ctggtcaccg tctcgagc 348 <210> 912 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 912 gaggtgcagc tgttggagtc tgggggaggc ttggtccagc ctggggggtc cctgcgtctc 60 tcctgtgctg cctccggatt cgcctttggt gattatggta tgaattgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcacat atttcttcta atggtcgttt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaactagt 300 ggttattttg aatactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 913 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 913 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt gattatggta tgaattgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcacat atttcttcta atggtcgttt tatatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaactagt 300 ggttactttg aatactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 914 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 914 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagg gagtatgtta tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attaatggtt tgggtaatgt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca ataccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggag accgcggtat attactgtgc gatacagctg 300 cctaattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 915 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 915 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt aatgatggga tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcattt attaatgttg atggtaggga gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaatggtct 300 cctgggcggg ttcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 916 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 916 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt ggttgggata tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attgctcatg agggtggtga gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatgtt 300 cctgggtctc ctctgtttga ctactggggt cagagaaccc tggtcaccgt ctcgagc 357 <210> 917 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 917 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat cagggttgga tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaggg attggttcga atggtcctcg gacatcctac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatcgggg 300 gagtattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 918 <211> 351 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 918 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagg cagagtgata tgtggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagtt attggtaata atggtgagtt tacatactac 180 gcagactcgg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagataat 300 tggctgttgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351 <210> 919 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 919 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat cttagtacta tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attggtgggg atggtagtca tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc ggaaggtacg 300 cagtattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 920 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 920 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt caccttttcg gcgtatacga tggagtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attggggtta cgggttatga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtggt 300 cagggttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 921 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 921 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggg gattatggga tgtcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatat attgatcctc tgggtcgtct tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagatttg 300 tcgtcgctgc agtatggggt gtcgcctaat tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 922 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 922 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttttt cattattcta tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attggtccgg ttggtcggga gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaatgatt 300 cagtcgccgt tgtttaagga ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 923 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 923 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tggtatgata tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcacgt attgatagtg ggggtaatca gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga atagcctgcg tgccgaggac accgcggtat attactgtgc ggaagcgtcg 300 ctttggaagt ggaggttgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 924 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 924 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gagtatggta tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atttctccgc tgggtatttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacatgct 300 acgtctcagg agtctttgcg gtcttttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 925 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 925 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagt aagtatgaga tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtcct 300 ctgcctgatg cgttttggac taggggtttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 926 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 926 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt acttattcta tggcgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attgatcggc atggtttggc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaactcct 300 ggttcttctt ggcagactgt ttttggctac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 927 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 927 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag tcgtatccta tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt attgatcatc atggtcattc gacatactac 180 gcagactccg cgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaattgctt 300 agggtttcga tgatttttgg ttttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 928 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 928 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgtg cagtatggga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatgg attagtagta gtggtacgta tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctacg tgccgaggac accgcggtat attactgtgc ggaaacgtct 300 aggatgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 929 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 929 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcgg cctccggatt cacctttcgg gagtatgata tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcactt atttcgcctc ctggtcgtac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagttgtg 300 attctgggtt atacgaatag gtttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 930 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 930 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcct aattacggga tgttgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attaattctt cgggtatgga gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatttttt 300 cgtctgaatg atcataattc tgtgtttggt tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 931 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 931 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttaag gattataaga tgatgtggat ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attgttgggt ctggttcgat gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcct 300 ggttattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 932 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 932 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcat aattatgcta tggggtgggt ccgccgggct 120 ccagggaagg gtctagagtg ggtctcaagt attgatgagc atggtactat tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatagt 300 ctggatcggg tttggatttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 933 <211> 366 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 933 gaggtgcagc tgttggagtc tggggggggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgct gattatccga tgacttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaagt atttattctg cgggttctcc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaactttat 300 catcgggagc cgattctttt tgggtttgac tactggggtc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 934 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 934 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag aggtatcaga tggcgtgggt ccgccaggct 120 ccggggaagg gtctagagtg ggtctcaacg attagttctg atggtggggg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctggt 300 catcggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 935 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 935 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt tcttatacta tgatgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcagag attgatcgga cgggtgagcg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaacctggg 300 tttgcttctc ttccttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 936 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 936 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttacg gattatacta tgtattgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaaag atttctccga gtggtcgttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatccg 300 tttgggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 937 <211> 357 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 937 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat gatgcggaga tgttttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct attgatgctc gtggtttgac gacatactac 180 gcagaccccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagcgacg 300 tcggctatgt atccttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357 <210> 938 <211> 363 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 938 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgt gattatgata tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atttctcctc ttggtcattt tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatctggg 300 tttcatgagt atactgaggg gtttgactac tggggtcagg gaaccctggt caccgtctcg 360 agc 363 <210> 939 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 939 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat cgtgcgggta tggggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcactg attgggcgtg gtggtgatat tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaattcgt 300 aatctgcatt gggatgtggg gaggcagttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 940 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 940 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttggt cgttatcaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatct atttcttctg atggtggggg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgtct 300 cgtcggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 941 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 941 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtt cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag ttgtatccga tggcgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcatcg atttctccgg ttggttttct gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagggcat 300 gaggggtcgt atactccgcg gtcggctttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 942 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 942 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgtg gcgtatccta tggcgtgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaact attgcgcctc tgggtggtaa tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacggccg 300 gaggggctgc agattgattc tcagaatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 943 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 943 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgcg ttgtatcaga tggcttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatcg attgattctt ctggtagtga tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctgag 300 cgtgattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 944 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 944 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttagg cagtaccaga tggcttgggc ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgcgtcgg atggtgtttc tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggt 300 cgtgattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 945 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 945 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag cagtatgata tgaggtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcatgg attgatgagg cgggtcatga gacatactat 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaggaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatg 300 gatgggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 946 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 946 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgtt gattatccga tgggttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttctacgg ggggtttttc gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgcgg 300 tattattatc ttagtcagat taagaatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 947 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 947 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat atttatggga tgacttgggt ccgccaggct 120 ccagggaagg gtctggagtg ggtctcaagt atttcgcctc ttggtcttgt tacatactac 180 gcagaccccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaactgaag 300 gagcatgggg atgttccttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 948 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 948 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag ctttatccga tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact atttctccta cgggtttgtt gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatttaag 300 aggagtggga agactgatga tactaatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 949 <211> 348 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 949 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttcgg gagtatgata tgctgtgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg attgtggggg atggtaatgg tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacaggat 300 cgtcagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348 <210> 950 <211> 360 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 950 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gagtatggta tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaacg atttcgccta ttggtgttac tacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaatgct 300 tatgatcgga agtctaattt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360 <210> 951 <211> 372 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 951 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgat cggtatgtga tggtgtgggt ccgccaggct 120 ccagggaagg atctagagtg ggtctcaggt attactccga gtggtaggag gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagga cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagtgttg 300 gggcgtcatt ttgatcctct tctgccttcg tttgactact ggggtcaggg aaccctggtc 360 accgtctcga gc 372 <210> 952 <211> 369 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 952 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60 tcctgtgcag cctccggatt cacctttgag gattatgcta tgagttgggt ccgccaggct 120 ccagggaagg gtctagagtg ggtctcaact attactccgg gtggtttttg gacatactac 180 gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaacgtct 300 agtggggagt tgcagttggt tgaggatttt gactactggg gtcagggaac cctggtcacc 360 gtctcgagc 369 <210> 953 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 953 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Lys His Ser 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr His Arg Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Arg His Arg Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 954 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 954 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly His Arg 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Arg Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Ala Leu Phe Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 955 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 955 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His Ile Gly His His 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Arg Ser His Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Trp Asp Arg Pro Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 956 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 956 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly His Arg 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Arg Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Arg Ala Val Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 957 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 957 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly His Arg 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Arg Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Arg Phe Ser Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 958 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 958 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly His Arg 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Arg Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ala Arg Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 959 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 959 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn His Arg 20 25 30 Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Arg Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Val Arg Pro Asn 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 960 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 960 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly His Arg 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Arg Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Ser Pro His 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 961 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 961 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly His Arg 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Arg Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Ala Val Arg Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 962 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 962 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly His Arg 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Arg Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Tyr Arg Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 963 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 963 Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asp Pro Met 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Gly Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Ser Ile Arg Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 964 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 964 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 965 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 965 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Ile Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 966 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 966 Asp Ile Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 967 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 967 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 968 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 968 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 969 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 969 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Val Ile Lys Arg 100 105 <210> 970 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 970 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Lys Gly Thr Lys Val Val Ile Lys Arg 100 105 <210> 971 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 971 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Arg Gly Thr Lys Val Val Ile Lys Arg 100 105 <210> 972 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 972 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Val Ile Lys Arg 100 105 <210> 973 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 973 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Met Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 974 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 974 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Tyr Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Lys Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Val Ile Lys Arg 100 105 <210> 975 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 975 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Val Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Val Ile Lys Arg 100 105 <210> 976 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 976 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 977 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 977 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Arg Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Thr Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 978 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 978 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Asp Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Val Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 979 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 979 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 980 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 980 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Glu Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Ser Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 981 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 981 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg 100 105 <210> 982 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 982 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 983 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 983 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ala Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Ile Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 984 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 984 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Val Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Gly Ile Lys Arg 100 105 <210> 985 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 985 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Asp Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 986 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 986 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 987 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 987 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Met Pro Ile Gly Pro Asp 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Thr Ser Ile Leu Arg Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ala Phe Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 988 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 988 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asp Thr 20 25 30 Leu Thr Trp Tyr Gln Gln Lys Leu Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Gly Ser Glu Leu Gln Ser Gly Val Pro Pro Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Cys Ile Ser Ser Pro Cys 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 989 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 989 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Phe Ile Gly Asp Ser 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Phe Ser Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Ser Pro Thr 85 90 95 Thr Phe Gly Arg Gly Thr Lys Val Lys Ile Lys Arg 100 105 <210> 990 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 990 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Tyr His Gly Tyr Pro Thr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 991 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 991 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Met Ile Asp Gln Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ala Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Gly Tyr Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 992 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 992 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Tyr Thr Ser 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 His Tyr Gly Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Val His Gln Ala Pro Thr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 993 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 993 Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asp Ser 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ile Ser Glu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Leu Ser Ser Ser Met Pro His 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 994 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 994 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Glu Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ser Ser His Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Gln Asn Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 995 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 995 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Arg Gln 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Thr Glu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gln Ser Lys Gly Pro Leu 85 90 95 Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 996 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 996 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Thr Asp 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Met Gly Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile Tyr Ser Phe Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 997 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 997 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Glu Glu Met 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Phe Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His His Thr Arg Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 998 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 998 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Met Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Ile Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Lys Leu Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 999 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 999 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Met Asp Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Lys Leu Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1000 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1000 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Glu Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser His Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Tyr Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1001 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1001 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Asp Glu Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Leu Leu Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1002 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1002 Asp Ile Gln Met Ile Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn Glu Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Lys Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Thr Asn Pro Thr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1003 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1003 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Glu Ala Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Ser Ser Glu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Met Ser Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1004 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1004 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asp Ser Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Met Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Asp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Leu Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1005 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1005 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asp Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ser Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ala Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Leu Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1006 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1006 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Glu Gly Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His His Leu Pro Thr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1007 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1007 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Thr Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Gly Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Arg Trp Ile Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1008 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1008 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Thr Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Leu Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Leu Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1009 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1009 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Thr Thr Ser 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Val Thr Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1010 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1010 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile His Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Gly Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ala Asn Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Gly Ile Lys Arg 100 105 <210> 1011 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1011 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile His Thr Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Gly Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Val Ser Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1012 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1012 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Asn Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Leu His Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1013 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1013 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asp Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Arg Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1014 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1014 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Ser Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Ala Ser Glu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Arg Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Gln Trp Pro Thr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1015 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1015 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Gly Asn Thr 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Leu Ser Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Lys Lys Pro Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1016 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1016 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile Lys Asn Arg 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Val Ser His Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Arg Gln Ser Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1017 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1017 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asp Ile Gly Glu Glu 20 25 30 Leu Phe Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Thr Leu Gln Ser Glu Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln His 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Glu Trp Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1018 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1018 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Ser Gly Gly 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Thr Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr Ser Ala Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1019 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1019 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asp Gln Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Val Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Met Asn Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1020 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1020 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Gln 20 25 30 Leu Lys Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Ala Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Leu Arg Pro Gln 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1021 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1021 Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile Ser Thr Ser 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Tyr Asn Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1022 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1022 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Gly Glu Ser 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Phe Ala Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His His Met Leu Pro Ser 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1023 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1023 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Phe Ile Gly Asp Ser 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Phe Ser Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Met Asp Ile Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1024 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1024 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asp His Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Ile Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1025 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1025 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gln Ile Glu Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Gly Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Leu Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1026 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1026 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asn Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr His Gly Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Phe Asn Pro Thr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1027 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1027 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Cys Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asp Gly Leu 20 25 30 Leu Trp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Gly Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Lys Ala Phe Glu Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1028 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1028 Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly His Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asn Val Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser His Asn Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1029 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1029 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His Ile Glu Asn Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser His Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Leu Gln Pro Thr 85 90 95 Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1030 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1030 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Val Ile Glu Gly Ser 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Arg Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Gln Leu Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1031 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1031 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Asn Gly Lys 20 25 30 Leu Phe Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Ala Phe Ala Ser Ala Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Gln Ala Val Tyr Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1032 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1032 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Glu Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Tyr Gln Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1033 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1033 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Glu His Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Gln Gln Pro Thr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1034 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1034 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Gln Ile Glu Glu Ser 20 25 30 Leu Trp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Ala Asp Val Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Val Val Glu Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1035 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1035 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Tyr Ile Gly Leu Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Arg Gln Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1036 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1036 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Thr Pro Ile Gly Thr Met 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly His Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln His Val Arg Pro Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1037 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1037 Asp Ile Gln Leu Thr Gln Ser Pro Thr Ser Leu Ser Ala Thr Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Thr Pro Ile Gly Thr Met 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly His Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln His Val Arg His Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1038 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1038 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Thr Pro Ile Gly Thr Met 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly His Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln His Val Arg Pro Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Gly Ile Lys Arg 100 105 <210> 1039 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1039 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Val Ser Thr Pro Ile Gly Thr Met 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly His Ser Ser Trp Leu Gln Ser Gly Val Pro Pro Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln His Val Arg Pro Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1040 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1040 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Thr Pro Ile Gly Thr Met 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly His Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Cys Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln His Val Arg Pro Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1041 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1041 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Thr Pro Ile Gly Thr Met 20 25 30 Ile Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly His Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln His Val Arg Pro Pro Ala 85 90 95 Thr Phe Gly Lys Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1042 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1042 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Tyr Ile Asp Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Gly Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Ile Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Val Val Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1043 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1043 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Val Asp Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Asp Arg Trp Ser Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1044 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1044 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Ile Gln His Met 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Gly His Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ser Cys Ala Trp Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1045 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1045 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Gly Ile Asp Gly Asp 20 25 30 Leu Trp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Ala Asp Ser Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Ala Val Arg Pro Met 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1046 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1046 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Gly Ile Asp Thr Asp 20 25 30 Leu Trp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Ala Asp Ser Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Ala Val Arg Pro Met 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1047 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1047 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Tyr Thr Ile Pro Val Ala 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Ala Asp Ala Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Trp Pro Gly Pro Gln 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1048 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1048 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ala Thr Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Thr Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Tyr Asn Pro Ser 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1049 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1049 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Val Pro Ile Thr Glu Gly 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gln Ala Asn Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Trp Glu His Val Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1050 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1050 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Met Ile Leu Tyr Gly 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Gly Thr Ser Ala Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Trp Glu Thr Val Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1051 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1051 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Asn Gly Leu 20 25 30 Leu Ile Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Met Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Ala Arg Ile Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Gly Ile Lys Arg 100 105 <210> 1052 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1052 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Leu Ile Arg Thr Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Ser Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Asp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1053 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1053 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asp Ser 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Phe Gly Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu His Thr Pro Ser 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1054 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1054 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Glu Ala Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr His Ser Ser Glu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Phe Asn Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1055 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1055 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Pro Ile Glu Tyr Gly 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Gly Gly Ser Ala Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Trp Glu Val Gln Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1056 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1056 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Arg Ile Asp Thr Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Ala Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1057 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1057 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Trp Ile Gly Met Ser 20 25 30 Leu Glu Trp His Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Arg Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Ser Arg Trp Pro Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1058 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1058 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asn Ile Ser Asn Ala 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Leu Gly Ala Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Thr Gln Val Trp Asp Arg Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1059 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1059 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Met Ser Ala 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Thr Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Leu Leu Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1060 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1060 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Gly Ile Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Ser 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Asn Pro Pro 85 90 95 Thr Phe Gly Arg Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1061 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1061 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Met Ile Gly Asp Trp 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Ser Ser Glu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr Phe Trp Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1062 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1062 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Glu Leu Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Val Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1063 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1063 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Glu His Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala Tyr Pro Pro 85 90 95 Thr Tyr Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1064 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1064 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Ala Ile Glu Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Phe 35 40 45 Tyr Asp Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Gly Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Tyr Asp Val Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1065 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1065 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Glu Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1066 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1066 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Glu His Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1067 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1067 Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln Ala Ile Glu His Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1068 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1068 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Glu Ser Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Val Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1069 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1069 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Glu His Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ala Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1070 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1070 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asp Glu Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Gln Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1071 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1071 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Glu Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Gln Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1072 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1072 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Glu Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gln Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1073 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1073 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Glu Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Gln Tyr Pro Pro 85 90 95 Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1074 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1074 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Glu Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Phe Gln Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1075 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1075 Glu Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Met Thr Cys Arg Ala Ser Gln Ser Ile Asp Lys Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Trp Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Arg Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Gln Tyr Pro Pro 85 90 95 Thr Leu Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1076 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1076 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Glu Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro 65 70 75 80 Glu Asp Ile Ala Thr Tyr Tyr Cys Lys Gln Tyr Ser Gln Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1077 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1077 Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asp Lys Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Trp Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr His Cys Gln Gln Tyr Phe Gln Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1078 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1078 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Tyr Ile Asn Ala Glu 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asn Ala Met Trp Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1079 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1079 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Leu Asp Ile Asn Asn Gly 20 25 30 Leu Ile Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Leu Gly Ala Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Gln Val Arg Ser Arg Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1080 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1080 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Leu Ser Ala 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ser Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asn Tyr Ser Leu Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1081 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1081 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Pro Ile Glu Ser Tyr 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Arg Tyr Val Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Trp Phe Arg Ala Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1082 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1082 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Val Ser Glu Ser Ile Asn Ala Glu 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Ser Gly Phe Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Phe Ala Met Trp Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1083 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1083 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Met Met Ile Arg Phe Gly 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Gly Gly Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln His Glu Arg Trp Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1084 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1084 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Thr Leu 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Leu Thr Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Met Val Tyr Arg Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1085 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1085 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Lys Val Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1086 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1086 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His His Ile Gln Arg Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Leu Trp Gly Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Trp Trp Ala Pro Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1087 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1087 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His His Ile Gln Arg Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Leu Trp Gly Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Trp Trp Ala Pro Pro Gln 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1088 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1088 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Asp Ile Gln Arg Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Leu Trp Gly Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Trp Trp Ala Pro Pro Gln 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1089 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1089 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Tyr Ile Asp Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Ala Val Val Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1090 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1090 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ala Phe Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ala Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Leu Gln Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1091 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1091 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Ala Thr Leu 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Gly Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Met Trp Gln Arg Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1092 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1092 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Val Asp Glu 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Trp Ser Thr Tyr Pro Thr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1093 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1093 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Asp Gly Val Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Asp Trp Asp Trp Pro Arg 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1094 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1094 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asn Ile Arg Asp Trp 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Asp Trp Gly Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Thr Trp Asp Asp Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1095 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1095 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Phe Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asn Ile Arg Asp Trp 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Asp Trp Gly Ser Glu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Thr Trp Tyr Asp Pro Leu 85 90 95 Thr Phe Gly His Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1096 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1096 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ile Asp Ile His Gly Gly 20 25 30 Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Val Gly Val Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Val Trp Arg Arg Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1097 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1097 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ser Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ala Leu Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1098 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1098 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gln Ile Glu Thr Asn 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Gly Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Lys Tyr Leu Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1099 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1099 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ala 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Leu Gly Ser Asp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Gln Tyr Phe Pro Thr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1100 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1100 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Tyr Gly Gly 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Glu Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr His Lys Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1101 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1101 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Arg Ile Gly Val Trp 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Gly Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Phe Ser Ser Pro Ser 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1102 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1102 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Pro Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Asp Glu 20 25 30 Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Gln Phe Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1103 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1103 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Asn Ile Thr Gly Pro 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Pro Gly Trp Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Val Trp Gly Glu Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1104 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1104 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Ile Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Arg Ile Ala Tyr Gly 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Gly Gly Arg Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Pro Gly Met Pro Pro Asp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1105 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1105 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Gln Ile Val Gly Gly 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Arg His Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Gly Val Trp Ala Pro Gly 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1106 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1106 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Pro Ala Ile Ala Ala Lys 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Ala Asp Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Trp Ala Gly Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1107 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1107 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Thr Ile Ala Asp Gly 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Ala Tyr Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Trp Glu Gly Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1108 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1108 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Arg Ile Tyr Gly Phe 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Val Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Leu Ala Trp Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1109 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1109 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Arg Asp Trp 20 25 30 Leu Met Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Trp Gly Ser Phe Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Tyr Asp Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1110 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1110 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asn Thr Gly 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Ser Ser Ala Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Ser Tyr Tyr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1111 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1111 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile Phe Gly Trp 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Thr Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Tyr Ser Leu Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1112 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1112 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Asn Ile Gly Ala Asp 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Gly Ala Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Trp Asn Gly Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1113 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1113 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Pro Ile Tyr Asp Gly 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Ser Gly Ala Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Trp Leu Gly Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gln 100 105 <210> 1114 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1114 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Arg Ile Tyr Asn Gly 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Gly Arg Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Val Gly Glu Ala Pro Ser 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1115 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1115 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Phe Ile Asn Glu Glu 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Ser Trp Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Pro Gly Gly Gly Pro Gly 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1116 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1116 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asp Ile Leu Asp Glu 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Gly Gly Gly Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Trp His Gly Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1117 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1117 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Pro Ile Tyr Thr Gly 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Gly Arg Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Met Gln Val Gly Thr Ala Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1118 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1118 Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Ser Arg Arg 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ser Ser Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Gly Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Tyr Ser Tyr Pro His 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1119 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1119 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Pro Ile Pro Gln Asp 20 25 30 Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Val Gly Ile Ser Gln Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Trp Ser Ala Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1120 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1120 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Asp Gly Met 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Pro Gly Phe Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Ser Val Glu Ala Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1121 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1121 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Tyr Ile Ala His Pro 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Pro Gly Ser Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Ser Val Val Val Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1122 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1122 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Thr Ile Glu Gly Gly 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Met Gly Gly Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Trp Val Gly Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1123 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1123 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Phe Ile Arg Asp Glu 20 25 30 Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Gly Gly Ser Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Trp Arg Ala Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1124 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1124 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Pro Ile Tyr Gly Gly 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Gly Gly Gly Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Val Trp Gly Gly Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1125 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1125 Asp Ile Arg Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Gly Cys 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Asp Gly Ala Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Trp Trp Glu Tyr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1126 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1126 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Pro Ile Val Arg Asp 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 His Gly Val Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Glu Ala Ala Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1127 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1127 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asp Ile Gly Asp Trp 20 25 30 Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Val Trp Ala Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Trp Gly Thr Pro Pro Thr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1128 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1128 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Asn Arg Ile Glu Tyr Gly 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Ser Gly Ser Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Ser 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Glu Ala Ala Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1129 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1129 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asn Ile Gly His Phe 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Leu Gly Gly Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Val Glu Pro Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1130 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1130 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Ser Ile Tyr Ser Asp 20 25 30 Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Asp Gly Trp Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu His Arg Ala Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1131 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1131 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Phe Ile Thr Asp Arg 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Gly Val Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Ser Ser Glu Leu Pro Trp 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1132 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1132 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Lys Ile Gly Ser Glu 20 25 30 Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Gly Arg Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Trp Glu Pro Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1133 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1133 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asn Ile Gly Asn Gly 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Gly Glu Gly Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Leu Trp His Thr Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1134 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1134 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asn Ile Tyr Gly Trp 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Gly Gly Trp Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asp Tyr Thr Leu Pro Gly 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1135 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1135 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Lys Asp Trp 20 25 30 Leu His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Phe Ala Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Tyr 85 90 95 Thr Ser Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1136 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1136 Asp Ile Gln Met Thr Gln Ser Pro Pro Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Leu Ile Ser Ser His 20 25 30 Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 35 40 45 Tyr Asp Ala Ser Glu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Arg Ser Leu Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1137 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1137 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Gly Ala 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gln Ile Ser Val Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ile Arg Ser Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1138 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1138 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ala Ala 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Leu Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Phe Arg Leu Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1139 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1139 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Gly Gly Arg 20 25 30 Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ser Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ala Glu Ala Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1140 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1140 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Ser Ser 20 25 30 Leu Ile Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Thr Leu Leu Ile 35 40 45 Tyr Tyr Ser Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Ser Ser Pro Tyr 85 90 95 Thr Val Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1141 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1141 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ser Glu 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Trp Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile Leu Glu Thr Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1142 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1142 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Lys Ile Trp Asp Ala 20 25 30 Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Arg Gly Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Tyr Arg Trp Pro His 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1143 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1143 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His Ile Glu Asp Ser 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Gly Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Met Tyr Lys Phe Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1144 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1144 Asp Ile Gln Thr Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Arg Ile Asn Ser Ser 20 25 30 Leu Leu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile Trp Gly Ser Pro Pro 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1145 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1145 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Pro Val Gly 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asp Trp Tyr Tyr Pro Asn 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1146 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1146 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Tyr Gly Trp 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Leu Thr Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile His Ser Ser Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1147 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1147 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Phe Ile Asp Thr Ser 20 25 30 Leu Glu Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Asp Gly Ser His Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Val Leu Pro Leu 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1148 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1148 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Gly Asp Ala 20 25 30 Leu Phe Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ser Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg His Ser Thr Pro Ala 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1149 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1149 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asp Glu Ser 20 25 30 Leu Met Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Gly Val Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Trp Lys Ala Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1150 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1150 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Glu Ile Val Glu Asp 20 25 30 Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Ala Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Arg Arg Arg Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1151 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1151 Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asp Pro Met 20 25 30 Leu Arg Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Gly Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Leu Val Thr Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1152 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1152 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asp Ala 20 25 30 Leu Phe Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Tyr Gly Ser Val Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Arg Phe Gln Glu Pro Val 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1153 <211> 108 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1153 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gln Ile Ser Asp Glu 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Val Ser Ile Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Leu Ser Phe Pro Ser 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 <210> 1154 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1154 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gagcaagtca gaatattaag cattcgttac ggtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctatcat cgttcccagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag gttaggcatc gtccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1155 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1155 gacatccaga tgacccagtc tccatcctct ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggctattggg catcggttac gttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcat cggtccaagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag gttgctttgt ttccctatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1156 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1156 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcatattggt catcatttaa ggtggtacca gcagaaacca 120 gggaaagccc ccaagctcct gatctatcat aggtcccatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattctg ctacgtacta ctgtcaacag tgggataggc cgccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1157 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1157 gacatccaga tgacccagtc cccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggctattggg catcggttac gttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcat cggtccaagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag gtgcgggctg tgccttatac gtttggccaa 300 gggaccaagg tggaaattaa acgg 324 <210> 1158 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1158 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggctattggg catcggttac gttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcat cggtccaagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag gttcgttttt ctccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1159 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1159 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggctattggg catcggttac gttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcat cggtccaagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tcttatgcta ggcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1160 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1160 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca aagtattaat cataggttat attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcat cggtccaggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaggattttg ctacgtacta ctgtcaacag tataaggtta ggcctaatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1161 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1161 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggctattggg catcggttac gttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatttatcat cggtccaagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag acttattcgt ctcctcatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1162 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1162 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggctattggg catcggttac gttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcat cggtccaagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctacaacct 240 gaagattttg ctacgtacta ctgtcaacag agggcggtga ggccttttac gttcggccaa 300 gggaccaaag tggaaatcaa acgg 324 <210> 1163 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1163 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggctattggg catcggttac gttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcat cggtccaagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag acttattatc gtcctcttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1164 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1164 gacatccaga tgacccagtc tccagcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgat cctatgttaa ggtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgcg ggttccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag actagtatta ggccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1165 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1165 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1166 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1166 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatatac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccatct tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtgaatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1167 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1167 gacatccaga taacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccatat tgcgaagtgg agtcccatca 180 cgtttcagtg gcagtgggtc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagatcttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1168 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1168 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagcttct gatctatcag acgtccattt tgcgaagtgg ggtcccatca 180 cgtttcagtg gcagaggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1169 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1169 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca acctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctctt gatctatcag acgtccattt tgcgaagtgg ggtcccatca 180 cgtttcagtg gcagcggatc tgggactgat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattggactt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1170 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1170 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcgaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgagacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggtaatcaa acgg 324 <210> 1171 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1171 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcgaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgagacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagatcttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggcaaa 300 gggaccaagg tggtaatcaa acgg 324 <210> 1172 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1172 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcgaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgagacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccga 300 gggaccaagg tggtaatcaa acgg 324 <210> 1173 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1173 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gagcaagtca gcctattggt cctgatttac tgtggtaccg gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcgaagtgg tgtcccatca 180 cgtttcagtg gcagtggatc tgagacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggtaatcaa acgg 324 <210> 1174 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1174 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccatta tgcgaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgagacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattggactt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1175 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1175 gacatccaga tgacccagtc tccatcctcc ctgtctgcat atgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcgaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgagacagat ttcaccctca ccatcagcaa tctgcaacct 240 gaagattttg ctaagtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggtgatcaa acgg 324 <210> 1176 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1176 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcgaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgagacagat ttcactctca ccatcagcaa tctgcaacct 240 gtagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tagtaatcaa acgg 324 <210> 1177 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1177 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggttcca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtgaatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1178 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1178 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctatcggt cctgatttac tgtggtaccg gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattggactt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1179 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1179 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattgat cctgacttac tgtggtacca gcagaaacca 120 ggtaaagccc ctaagctcct gatctatcag acgtccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagtt ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggcat ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1180 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1180 gacatccaga tgacccagtc tccatcctcc ctgtctgcat cagtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaagcca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcgaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1181 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1181 gacatccaga tgacccagtc tccatcatcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattgaa cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ctcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1182 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1182 gacatccaga tgacccagtc accatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggctagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcaaagtgg ggtcccatca 180 cgtttcagcg gcagtgaatc cgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagatattg caacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaggg tggaaatcaa acgg 324 <210> 1183 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1183 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcaaagtgg ggtcccttca 180 cgtttcagtg gcagtgaatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1184 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1184 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcgcc 60 atcacttgcc gggcaagtca gcctattggt cctgatatac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcgaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattctg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggtcaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1185 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1185 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcgaagtgg ggtcccgtca 180 cgtttcagtg gcagtggatc tgtgacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tgggaatcaa gcgg 324 <210> 1186 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1186 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattgat cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc taggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1187 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1187 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag acgtccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcgg tctgcaacct 240 gaagattttg ctacgtacta ctgtcagcag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1188 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1188 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtat gcctattggt cctgatttac tgtggtacca gcagaaacca 120 gggaaggccc ctaagctcct gatctatcag acgtccattt tgcgaagtgg ggtcccatca 180 cgtttcagtg gcagtgaatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggctt ttcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1189 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1189 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtggattggg gatacgttaa cgtggtacca gcagaaacta 120 gggaaagccc ctaagctcct gatctatggt ggttccgagt tgcaaagtgg ggtcccacca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tgtattagta gtccttgtac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1190 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1190 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtttattggt gattctttat cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatttt tcttccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatactt cgcctactac gttcggccga 300 gggaccaagg tgaaaatcaa acgg 324 <210> 1191 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1191 gacatccaga tgacccagtc tccatcctcc ctgtccgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gactattgag actaatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat tcttcccagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat tttactctca ccatcagcag tctgcaacct 240 gaagatttag ctacgtacta ctgtcaacag tatcatgggt atcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1192 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1192 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gatgattgat caggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctataat gcgtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatggtt atcctattac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1193 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1193 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gacgatttat acttcgttaa gttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatccattat ggttccgtgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattctg ctacgtacta ctgtcaacag gttcatcagg ctcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1194 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1194 gacatccgga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtggattggg gattctttag cgtggtacca gcagaagcca 120 gggaaagccc ctaagctcct gatctatggt atttccgagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattctg ctacgtacta ctgtcaactg tctagtagta tgcctcatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1195 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1195 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggagattgag acgaatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat tcgtcccatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatcaga atcctccgac gttcggccaa 300 ggaaccaagg tggaaatcaa acgg 324 <210> 1196 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1196 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtggattggg aggcagttag tttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggg gcgaccgagt tgcaaagtgg ggtcccatca 180 cgttttagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag cagtcgaagg gtcctcttac gttcggccat 300 gggaccaagg tggaaatcaa acgg 324 <210> 1197 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1197 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggggattggt actgatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatatg ggttcctatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag atttattctt ttcctattac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1198 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1198 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgag gagatgttac attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatttt ggttccctgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtagatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag catcatactc gtccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1199 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1199 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattggg atggatttag agtggtacca gcagatacca 120 gggaaagtcc ctaagctcct gatctatgat gcgtcctatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcataagc ttcctgcgac gtttggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1200 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1200 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattatg gataatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgcg gcgtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcataagt tgcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1201 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1201 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gagcaagtca gaatattggg gaggatttag agtggtacca gcagaaacca 120 gggaatgccc ctaagctcct gatctatagt gcgtcccatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattctagtt atcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1202 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1202 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ccgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gccgattgat gaggatttag agtggtacca gcagaaacca 120 gggaatgccc ctaagctcct gatctatagt gcgtcctatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag actgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatcttc tgcctgctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1203 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1203 gacatccaga tgatccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattaat gaggatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataat gcttccatgt tgcaaagcgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 aaagattttg ctacgtacta ctgtcaacag tatcatacta atcctactac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1204 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1204 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgag gcggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcat tcttccgagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gaagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatatgt cgcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1205 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1205 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgat agtgatttag agtggtacca gcagaaacca 120 gggaaagccc ctatgctcct gatctattct tcgtccgatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatagtc tgcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1206 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1206 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatatttcg gatgatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctataat tcgtcctttt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tggggcagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatagtt tgcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1207 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1207 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgag ggtaatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat tcgtcccagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtgggtc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatcatc ttcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1208 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1208 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagtattgat acggatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat gggtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat tttactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcggtgga ttcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1209 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1209 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagtattagt actgatttag agtggtacca gcagaaacta 120 gggaaagccc ctaagctcct gatctatgat gcttcccttt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattcgagtc tgcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1210 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1210 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattacg acgtctttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat gcgtccatgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattgggtta cgcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1211 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1211 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacctgcc gggcaagtca gaatattcat acgaatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat ggttccatgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattcggcta atcctgttac gttcggccaa 300 gggaccaagg tgggaatcaa acgg 324 <210> 1212 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1212 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtggattcat acggatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat ggttccatgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatagtgtgt cgcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1213 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1213 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagtattgat aataatttag agtggtacca gcagaaacca 120 ggggaagccc ctaagctcct gatctatgat gggtcccttt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctta ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatcttc atcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1214 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1214 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgat acgaatttag agtggtatca gcagaaacca 120 ggggaagccc ctaagctcct gatctatgat cgttccacgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgattctt atcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1215 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1215 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtctattgag tctaatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctataat gcgtccgagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcgacct 240 gaagattttg ctacgtacta ctgtcaacag tatgatcagt ggcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1216 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1216 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcact 60 atcacttgcc gggcaagtca ggctattggt aatactttac ggtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt agttccaggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat tttactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag ctgaagaagc ctccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1217 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1217 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gaagattaag aatcggttag cgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgag gtttcccatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcggcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag aggaggcagt cgccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1218 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1218 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtga ggatattggg gaggagttat tttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctattcg gcgtccacgt tgcaaagtga ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacat 240 gaagattttg ctacgtacta ctgtcaacag gtttatgagt ggccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1219 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1219 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctatttct gggggtttaa ggtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctattct acttccatgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag ctttattctg ctccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1220 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1220 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgat caggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctataat gtttccctgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattctatga atcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1221 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1221 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattggg aatcagttaa agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag gcttccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgatttga ggcctcagac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1222 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1222 gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggtga ccgtgtcacc 60 atcacttgcc gggcgagtca gaagatttct acgtctttag agtggtatca gcagaaacca 120 gggaaagccc ctaggctcct gatctatgat tcttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccattagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgagtata atcctattac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1223 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1223 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gacgattggg gagagtttac attggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctatttt gcttccctgt tgcaaagtgg ggtcccatcg 180 cgtttcagtg gcagtggatc tgggacagat tttactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag catcatatgc ttccttctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1224 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1224 gacatccaaa tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtttattggt gattctttat cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatttt tcttccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatatggata ttcctattac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1225 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1225 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgat cataatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat agttccatgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcattcta ttcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1226 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1226 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcagattgag acgaatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat ggttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatagtt tgcctgctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1227 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1227 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattggt aataatttag agtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctatcat gggtcctggt tgcaaagtgg ggtcccatcg 180 cgtttcagtg gcagtggatc tgggacagat ttcactctta ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgatttta atcctactac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1228 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1228 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ctgtgtcacc 60 atcacttgcc gggcaagtca gaatattgat ggtctgttat ggtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgcg gggtccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag aaggcttttg agccttttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1229 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1229 gacatccaga tgacccagac tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagtattggt catgatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctataat gtgtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat tttactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatagtcata atcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1230 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1230 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcact 60 atcacttgcc gggcaagtca gcatattgag aatgatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctattct gcttcccatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatcttc agcctacgac gttcggccca 300 gggaccaagg tggaaatcaa acgg 324 <210> 1231 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1231 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcact 60 atcacttgcc gggcaagtca ggttattgag ggtagtttaa attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcat aggtccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gccgtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag acttatcagc ttcctttgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1232 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1232 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg tcctattaat ggtaagttat tttggtacca gcagaaacca 120 ggcaaagccc ctaagctcct gatcgcgttt gcttccgctt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgtgcag caggctgtgt atcctattac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1233 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1233 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggctattgag acgaatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat gggtcccttt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagaggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcattatc agcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1234 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1234 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgag catgatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctattcg gcgtcccagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcagcagc agcctactac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1235 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1235 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagttc gcagattgag gagtctttat ggtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgcggat gtttccctgt tgcaaagtgg agtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgctcag ggtgtggtgg agcctcgtac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1236 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1236 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtatattggt ctggatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattttcggc agcctattac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1237 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1237 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtac gccgattggt actatgttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgggcat tcgtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag catgtgcgtc ctcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1238 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1238 gacatccagt tgacccagtc tccaacctcc ctgtctgcaa ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtac gccgattggt actatgttag attggtacca gcagaaacct 120 gggaaagccc ctaagctcct gatcgggcat tcgtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggactgat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag catgtgcgtc atcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa gcgg 324 <210> 1239 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1239 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtac gccgattggt actatgttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgggcat tcgtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggacag catgtgcgtc ctcctgcgac gttcggccaa 300 gggaccaagg tgggaatcaa acgg 324 <210> 1240 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1240 gacatccaga tgacccagtc tccgtcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggtaagtac gccgattggt actatgttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgggcat tcgtcctggt tgcaaagtgg ggtcccacca 180 cgtttcagtg gcagcggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag catgtgcgtc ctcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1241 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1241 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtac gccgattggt actatgttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgggcat tcgtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gctgtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag catgtgcgtc ctcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1242 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1242 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtac gccgattggt actatgatag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgggcat tcgtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag catgtgcgtc ctcctgcgac gttcggcaaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1243 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1243 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacatgcc gggcaagtca gtatattgat actaatttag agtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctatgat ggttcccagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca tcatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcaggttg tgcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1244 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1244 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatcgtggat tcttccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag gatcgttggt ctcctgctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1245 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1245 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagttc gcggattcag catatgttat cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcggtggg cattccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgcgcaa tcgtgtgcgt ggcctctgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1246 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1246 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag gggtattgat ggtgatttat ggtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgcggat tcttccctgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag ggggctgttc ggcctatgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1247 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1247 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag gggtattgat actgatttat ggtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgcggat tcttccctgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag ggggctgttc ggcctatgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1248 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1248 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtta tactattccg gttgctttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgctgat gcgtccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgcgcag ggttggccgg ggcctcagac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1249 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1249 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagtattgcg acggacttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat acttccatgt tgcaaagcgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatagttata atccttcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1250 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1250 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtgt gcctattact gagggtttat cgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatccaggct aattcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag tgggagcatg ttcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1251 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1251 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag tatgattctt tatggtttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcggtggt acttccgcgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag tgggagacgg ttcctgctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1252 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1252 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattaat gggcttttaa tttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgcg atgtccagtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag ttggctcgga ttccttttac gttcggccaa 300 gggaccaagg tgggaatcaa acgg 324 <210> 1253 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1253 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gagcaagtca gctgattcgg acttatttag cgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcag tcttctcagt tgcaaagtgg tgtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tataattctt atcctgatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1254 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1254 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtggattggg gattcgttaa gttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatttt ggttcctatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatttgcata ctccttcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1255 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1255 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgag gcggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcat tcttccgagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatggtttta atcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1256 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1256 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagttc tcctattgag tatggtttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgggggg gggtccgcgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag tgggaggttc agcctgctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1257 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1257 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcggattgat actgatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat agttcacagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatcatagtg cgcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1258 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1258 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtgg gtggattggt atgtctttag agtggcacca gcagaaacca 120 gggaaagccc ctaagctcct gatccgtggg gcttcctctt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtagtcag tctcggtggc cgcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1259 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1259 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg taatatttcg aatgctttat cgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatccttggg gcttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtactcag gtgtgggata ggccttttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1260 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1260 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattatg tcggctttat cttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctattct acttccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag gtttatttgc tgcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1261 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1261 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggagattggg attgatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcttcttatt tgcaaagtgg ggtcccatca 180 cgtttcagta gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgcttcta atcctcctac gttcggccga 300 gggaccaagg tggaaatcaa acgg 324 <210> 1262 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1262 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gatgattggg gattggttaa attggtacca gcagaaacca 120 gggaaagccc ctaaactcct gatctatcgt agttccgagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag ttgtattttt ggcctcgtac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1263 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1263 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggcgattgag cttaatttag agtggtacca gcagaaacca 120 gggaaggccc ctaagctcct gatctatgat gcttccatgt tgcaaagcgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccattagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgatgttt atcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1264 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1264 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggccagtca ggcgattgag cataatttag agtggtacca gcagaagcca 120 gggaaggccc ctaagctcct gatctatgat gcttccatgt tgcaaagcgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccattagcag tctccaacct 240 gaagatttag ctacgtacta ctgtcaacag tatgatgctt atcctcctac gtacggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1265 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1265 gacatccaga tgacacagtc tccatcctcc ctgtccgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg ggcgatagag actaatttag agtggtacca gcagaaacca 120 gggaaggccc ctaagctcct gttctatgat gcttccatgt tgcaaagcgg ggtcccatca 180 cgtttcggtg gcagtggatc tgggacagat ttcactctca ccattagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtctacag tatgatgttt atcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1266 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1266 gacatccaga tgacccagtc tccatcctcc ctgtctgcaa ctgtaggaga ccgtgtcacc 60 atcacttgtc gtgcaagtca ggcgattgag actaatttag agtggtacca gcagaaacca 120 gggaaggccc ctaagctcct gatctatgat gcttccatgt tgcaaagcgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagac ttcactctca ccattagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgatgctt atcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1267 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1267 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggcgattgag cataacttag agtggtacca gcagaaacca 120 gggaaggccc ctaagctcct gatctatgat gcttccatgt tgcaaagcgg ggtcccatca 180 cgtttcagtg gcagaggatc tgggacagat ttcactctca ccattagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgatgctt atcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1268 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1268 gacatccaga tgaaccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtctcc 60 atcacttgca gggcaagtca ggctattgag cataatttag agtggtacca gcagaaacca 120 gggaaggccc ctaagctcct gatctatgat gcttccatgt tgcaaagcgg ggtcccatca 180 cgcttcagtg gcagtggatc tgggacagat ttcactctca ccattagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgatgctt atcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1269 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1269 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggcgattgag tctaatttag agtggtacca gcaaaaacca 120 gggaaggccc ctaagctcct gatctatgat gcttccatgt tgcaaagcgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccattagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgatgttt atcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1270 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1270 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gtgcaagtca ggcgattgag cataatttag agtggtacca gcagaaacca 120 gggaaggccc ctaagctcct gatctatgat gcttccatgt tgcaaagcgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccattagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgatgctt atcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1271 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1271 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gggtattgat gaggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctattct agttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg ggagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattttcagt atcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1272 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1272 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagtattgat gaggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctattct agttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg ggagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattttcagt atcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1273 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1273 gacatccaga tgacccagtc tccatcctcc ctgtccgcat ctgtaggaga ccgtgtcacc 60 atcacttgca gggcaagtca gagtattgat gaggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctattct agttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg ggagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattctcagt atcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1274 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1274 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagtattgaa gaggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctattct agttcctggt tgcaaagcgg ggtcccatca 180 cgtttcagtg ggagtggctc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tattttcagt atcctccgac gttcggccat 300 gggaccaagg tggaaatcaa acgg 324 <210> 1275 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1275 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagtattgat gaggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctattct agttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg ggagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtactt ctgtcaacag tattttcagt atcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1276 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1276 gagatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atgacttgcc gggcaagtca gagtattgat aaggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctattct agttcctggt tgcaaagagg ggtcccatca 180 cgtttcagtg ggagtggatc tgggacagat ttcactctca ccatcagcag tctgcgacct 240 gaagattttg ctacgtacta ctgtcaacag tattttcagt atcctccgac gttgggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1277 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1277 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60 atcacttgcc gggcaagtca gagtattgat gaggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctattct agttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg ggagtggatc tgggacagat ttcactctca ccatcagcgg tctgcaacct 240 gaagatatcg ctacgtacta ctgtaaacag tattctcagt atcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1278 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1278 gacatccaga tgacccagtc cccaccctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagtattgat aaggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctattct agttcctggt tgcaaagagg ggtcccatca 180 cgtttcagtg ggagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacca ctgtcaacag tattttcagt atcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1279 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1279 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtga gtatattaat gctgagttag cttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggg agttccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtctgcag aatgcgatgt ggcctattac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1280 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1280 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtct ggatattaat aatggtttaa tttggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatcttgggt gcgtccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgttcgcag gtgcgttctc ggccttttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1281 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1281 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattctg agtgcgttag cttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggg agttccgttt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc agggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag aattatagtc ttcctattac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1282 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1282 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagttc tcctattgag tcgtatttaa ggtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcaggtat gtgtccgtgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag tggtttcggg cgcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1283 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1283 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggtaagtga gtctattaat gctgagttac attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctctggg ttttccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgtgcag tttgcgatgt ggccttttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1284 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1284 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtat gatgattagg tttgggttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcggtggt gggtcctctt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag catgagcggt ggcctgctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1285 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1285 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagtattggt actcttttac gttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatctt acttccgttt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag atggtttatc gtccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1286 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1286 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gactattgag actaatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat tcttcccagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgataagg ttcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1287 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1287 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca tcatattcag aggtatttat cgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcctttgg ggttcccagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag tggtgggctc ctcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1288 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1288 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca tcatattcag aggtatttat cgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcctttgg ggttcccagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag tggtgggctc ctcctcagac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1289 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1289 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca tgatattcag aggtatttat cgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcctttgg ggttcccagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag tggtgggctc ctcctcagac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1290 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1290 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacatgcc gggcaagtca gtatattgat actaatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat ggttccctgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag ggggctgttg tgcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1291 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1291 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgct tttgatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctattcg gcgtccatgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggtcagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tataatcttc agcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1292 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1292 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gaatattgct acgctgttac gttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct ggttccatgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag atgtggcagc gtccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1293 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1293 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattgtt gatgagttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcgtccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcatcag tggtctactt atcctacgac gttcggccaa 300 gggaccaagg tggaaattaa acgg 324 <210> 1294 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1294 gacatccaga tgacccaatc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtacca gcagaaacca 120 gggaaagccc ctaagctcct aatcgatggt gtttccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag gattgggatt ggcctcgtac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1295 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1295 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag gaatattcgt gattggttac ggtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgattgg gggtccgtgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgctcag acgtgggatg atcctctgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1296 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1296 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ttgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag gaatattcgt gattggttac ggtggtacca acagaaacca 120 gggaaagccc ctaagctcct gatcgattgg gggtccgagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgctcag acgtggtatg atcctctgac gttcggccac 300 gggaccaagg tggaaatcaa acgg 324 <210> 1297 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1297 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtat tgatattcat ggtggtttaa cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgtgggg gtttccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg ctacgtacta ctgtgcgcag gtgtggcgta ggccttttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1298 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1298 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattggg agttcgttat cttggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct tcttccctgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag acttatgctc ttcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1299 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1299 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcagattgag acgaatttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat ggttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tataagtatc tgcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1300 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1300 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggtga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattggg tctgcgttaa ggtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatttg ggttccgatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag acgcagtatt ttcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1301 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1301 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggcgatttat ggggggttac ggtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggg gagtccatgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcatcct 240 gaagattttg ctacgtacta ctgtcaacag gtttatcata agccttttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1302 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1302 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacgtgcc gggcaagtca gcgtattggg gtgtggttag attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat ggttcctttt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag actttttcga gtccttctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1303 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1303 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcccc 60 atcacttgcc gggcaagtca gtggattggg gatgagttat attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatagt tcttccactt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tcgtttcagt ttccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1304 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1304 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag taatattacg gggccgttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatccctggt tggtccactt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag gtgtgggggg agcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1305 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1305 gacatccaga tgacccagtc tccatcctcc ctgtctgcgt ctataggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcgtattgct tatggtttac attggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatcgggggg cggtccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgtgcag cctgggatgc cgcctgatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1306 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1306 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtaa gcagattgtt ggtggtttat cttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgggcgt cattctgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgtgcag ggggtttggg ctcctgggac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1307 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1307 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcc tgctattgct gctaagttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcggtgcg gattccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ctgtgggcgg ggcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1308 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1308 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg tactattgct gatgggttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcggggcg tattccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ctttgggagg gtcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1309 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1309 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gaggatttat gggtttttag attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggg gtgtcctcgt tgcaaagtgg ggtcccatca 180 cgttttagtg gcagcggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag actttggcgt ggccttttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1310 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1310 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattcgg gattggttaa tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctattgg ggttcctttt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag ctgtatgata ctccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1311 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1311 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gaatattaat acgggtttag attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat agttccgctt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag acgtcgtatt atccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1312 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1312 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gaagattttt ggttggttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggg acttccaagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag gtttattcgc ttccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1313 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1313 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagttc gaatattggg gcggatttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgggggg gcgtccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag ctgtggaatg ggcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1314 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1314 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag tccgatttat gatggtttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctctggt gcttcctggt tgcaaagtgg ggtcccatca 180 cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ttgtggttgg gtcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acag 324 <210> 1315 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1315 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagttc gcgtatttat aatggtttac attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcggtggt cggtccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgctcag gtgggggagg ctccttctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1316 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1316 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag gtttattaat gaggagttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctcgtgg tcttcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgtgcag ccggggggtg gtcctgggac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1317 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1317 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag ggatattctg gatgagttag attggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatcggtggg gggtccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag ctgtggcatg ggcctccgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1318 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1318 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag tcctatttat acgggtttac attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcggtggg cggtccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtatgcag gttgggacgg ctcctgctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1319 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1319 gacatccgga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gaatatttct aggcggttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctattct tcttcccggt tgcaaagtgg ggtcccatca 180 cgtttcggtg gcagtggatc tgggacggat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag acgtatagct atcctcatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1320 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1320 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag tccgattccg caggatttat attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgttggg atttcccagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag ttgtggagtg cgcctgctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1321 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1321 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtaa gtctattgat gggatgttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatccctggt ttttccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag tcggttgagg cgccttggac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1322 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1322 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg gtatattgct catcctttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcccgggt tcgtccgttt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtggtcag tcggttgtgg tgccttggac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1323 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1323 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg gacgattgag ggtggtttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcatgggg ggttccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag ttgtgggtgg gtcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1324 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1324 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtaa gtttattagg gatgagttat attggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatcggtggt tcgtccttgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag ctgtggcggg cgcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1325 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1325 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtaa gccgatttat ggtggtttag agtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatcgggggg ggttccgtgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag gtgtgggggg gtcctgttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1326 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1326 gacatccgga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg gccgattagt ggttgtttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgatggg gcttccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag tggtgggagt atcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1327 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1327 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtaa gcctattgtg agggatttag agtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatccatggt gtgtccacgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag cttgaggcgg cgcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1328 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1328 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg ggatattggt gattggttat attggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatcgtttgg gcgtccgtgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgcgcag tgggggactc ctcctacgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1329 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1329 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtaa tcgtattgag tatggtttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctcgggg tcttcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagta gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag cttgaggcgg cgcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1330 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1330 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg gaatattggg cattttttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcttgggg gggtcctcgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagcgggtc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag ttggtggagc ctcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1331 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1331 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagttc gagtatttat agtgatttat attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcgatggg tggtccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag ctgcatcgtg ctcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1332 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1332 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag gtttattact gatcgtttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcggtggt gtttccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag agttcggagt tgccttggac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1333 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1333 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg taagattggt agtgagttat attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcggtggt aggtcccggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag ttgtgggagc ctcctgcgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1334 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1334 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtag gaatattggt aatggtttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatcggggag gggtcccgtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgggcag ctttggcata ctcctcctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1335 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1335 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtcg gaatatttat ggttggttat cgtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatcggtggg tggtccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtgcgcag gattatacgt tgcctggtac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1336 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1336 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattaag gattggttac attggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatttt gcgtccggtt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattctg ctacgtacta ctgtcaacag cattatagta cgccttatac gtccggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1337 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1337 gacatccaga tgacccagtc tccaccctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gttgatttct tctcatttag attggtacca gcagaaacca 120 gggaaagccc ctaagctcct ggtctatgat gcttccgagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag catcgcagtc tgccttttac gttcggccaa 300 gggaccaagg tagaaatcaa acgg 324 <210> 1338 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1338 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtggattggt ggggcgttag cgtggtacca gcagaaacca 120 gggaaagccc ctaggctcct tatctatcag atttccgttt tgcaaagtgg gatcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatattcggt ctccttttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1339 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1339 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gagtattggg gcggcgttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggt ctgtcctctt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag ctgtttaggc ttcctttgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1340 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1340 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctattggg ggtcgtttag tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggg tcttccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tatgctgagg ctcctattac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1341 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1341 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gaatattggg tctagtttaa tttggtacca gcagaaacca 120 gggaaagccc ctacgctcct gatctattat tcgtccaagt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tctttgtcga gtccttatac ggtcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1342 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1342 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtggattggg agtgagttag cgtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctattgg acgtccaatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag attctggaga ctcctttgac gtttggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1343 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1343 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gaagatttgg gatgctttat attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatcgt gggtccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag ttttatcggt ggcctcatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1344 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1344 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcatattgag gattctttac ggtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctattat ggttccgtgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag atgtataagt ttcctattac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1345 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1345 gacatccaga cgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcggattaat tcttctttac tgtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat acttccactt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtagatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagatttcg ctacgtacta ctgtcaacag atttggggtt cgcctcctac gttcggccag 300 gggaccaagg tggaaatcaa acgg 324 <210> 1346 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1346 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtcgattcct gttggtttaa attggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctattct gggtccactt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag gattggtatt atcctaatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1347 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1347 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcctatttat ggttggttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatttg acgtccgggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag attcatagtt ctccttttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1348 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1348 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtttattgat acgtcgttag agtggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgat gggtcccatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagatttag ctacgtacta ctgtcaacag tattgggttc ttcctctgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1349 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1349 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattggg gatgctttat tttggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctattat tcttccatgt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcggtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag cggcatagta ctcctgctac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1350 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1350 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgat gagtctttaa tgtggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctatggg gtgtcctatt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagatttcg ctacgtacta ctgtcaacag cggtggaagg ctccttttac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1351 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1351 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgttacc 60 atcacttgcc gggcaagtca ggagattgtg gaggatttat attggtatca gcagaaacca 120 gggaaagccg ctaagctcct gatctatggt gcgtcctggt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag acgcgtaggc gtccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1352 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1352 gacatccaga tgacccagtc tccagcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca ggatattgat cctatgttaa ggtggtacca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgcg ggttccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag acgctggtga ctccttatac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1353 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1353 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gtcgatttcg gatgcgttat tttggtacca gcagaaacca 120 gggaaagccc ctaggctcct gatctattat ggttccgttt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag cgttttcagg agcctgtgac gttcggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1354 <211> 324 <212> DNA <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polynucleotide" <400> 1354 gacatccaga tgacccagtc tccatcctcc ctgtccgcat ctgtaggaga ccgtgtcacc 60 atcacttgcc gggcaagtca gcagattagt gatgagttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gtgtccattt tgcaaagtgg ggtcccatca 180 cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg ctacgtacta ctgtcaacag tggttgagtt ttccttcgac gtttggccaa 300 gggaccaagg tggaaatcaa acgg 324 <210> 1355 <211> 353 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1355 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp Glu 20 25 30 Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Lys Val Gly Lys Asp Ala Lys Ser Asp Tyr Arg Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Glu Pro Lys Ser Ser Asp Lys 115 120 125 Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser 130 135 140 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 145 150 155 160 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 165 170 175 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 180 185 190 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 195 200 205 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 210 215 220 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 225 230 235 240 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 245 250 255 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 260 265 270 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 275 280 285 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 290 295 300 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 305 310 315 320 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 325 330 335 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 340 345 350 Lys <210> 1356 <211> 10 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 1356 Ala Ser Thr His Thr Cys Pro Pro Cys Pro 1 5 10 <210> 1357 <211> 18 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 1357 Ala Ser Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro 1 5 10 15 Ser Pro <210> 1358 <211> 10 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 1358 Ala Ser Thr His Thr Ser Pro Pro Ser Pro 1 5 10 <210> 1359 <211> 18 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 1359 Ala Ser Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro 1 5 10 15 Ser Pro <210> 1360 <211> 10 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 1360 Ala Ser Thr His Thr Ser Pro Pro Ser Pro 1 5 10 <210> 1361 <211> 24 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic peptide" <400> 1361 Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 1 5 10 15 Ala Glu Val Gln Leu Leu Glu Ser 20 <210> 1362 <211> 370 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1362 Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 1 5 10 15 Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 20 25 30 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp 35 40 45 Glu Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 50 55 60 Val Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser 65 70 75 80 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 85 90 95 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 100 105 110 Cys Val Lys Val Gly Lys Asp Ala Lys Ser Asp Tyr Arg Gly Gln Gly 115 120 125 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Glu Pro Lys Ser Ser Asp 130 135 140 Lys Thr His Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly 145 150 155 160 Ser Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 165 170 175 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 180 185 190 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 195 200 205 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 210 215 220 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 225 230 235 240 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 245 250 255 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 260 265 270 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 275 280 285 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 290 295 300 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 305 310 315 320 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 325 330 335 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 340 345 350 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 355 360 365 Gly Lys 370 <210> 1363 <211> 362 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1363 Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 1 5 10 15 Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 20 25 30 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp 35 40 45 Glu Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 50 55 60 Val Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser 65 70 75 80 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 85 90 95 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 100 105 110 Cys Val Lys Val Gly Lys Asp Ala Lys Ser Asp Tyr Arg Gly Gln Gly 115 120 125 Thr Leu Val Thr Val Ser Ser Ala Ser Thr His Thr Ser Pro Pro Ser 130 135 140 Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro 145 150 155 160 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 165 170 175 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 180 185 190 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 195 200 205 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 210 215 220 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 225 230 235 240 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 245 250 255 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 260 265 270 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 275 280 285 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 290 295 300 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 305 310 315 320 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 325 330 335 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 340 345 350 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 355 360 <210> 1364 <211> 370 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1364 Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 1 5 10 15 Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 20 25 30 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp 35 40 45 Glu Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 50 55 60 Val Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser 65 70 75 80 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 85 90 95 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 100 105 110 Cys Val Lys Val Gly Lys Asp Ala Lys Ser Asp Tyr Arg Gly Gln Gly 115 120 125 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Glu Pro Lys Ser Ser Asp 130 135 140 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 145 150 155 160 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 165 170 175 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 180 185 190 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 195 200 205 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Gln Ser Thr Tyr Arg 210 215 220 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 225 230 235 240 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 245 250 255 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 260 265 270 Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 275 280 285 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 290 295 300 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 305 310 315 320 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 325 330 335 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 340 345 350 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 355 360 365 Gly Lys 370 <210> 1365 <211> 362 <212> PRT <213> Artificial Sequence <220> <221> source <223> /note="Description of Artificial Sequence: Synthetic polypeptide" <400> 1365 Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 1 5 10 15 Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 20 25 30 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Trp 35 40 45 Glu Leu Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 50 55 60 Val Ser Gly Ile Glu Gly Pro Gly Asp Val Thr Tyr Tyr Ala Asp Ser 65 70 75 80 Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 85 90 95 Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 100 105 110 Cys Val Lys Val Gly Lys Asp Ala Lys Ser Asp Tyr Arg Gly Gln Gly 115 120 125 Thr Leu Val Thr Val Ser Ser Ala Ser Thr His Thr Cys Pro Pro Cys 130 135 140 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 145 150 155 160 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 165 170 175 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 180 185 190 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 195 200 205 Glu Gln Tyr Gln Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 210 215 220 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 225 230 235 240 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 245 250 255 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 260 265 270 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 275 280 285 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 290 295 300 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 305 310 315 320 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 325 330 335 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 340 345 350 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 355 360

Claims (42)

  1. 인간 CD40L에 특이적으로 결합하는 제1 가변 도메인을 포함하는 단리된 항체 폴리펩티드이며, 여기서 CD40L은 서열 1의 아미노산 서열을 포함하고, 제1 가변 도메인의 아미노산 서열은
    (a) BMS2h-572-633의 CDR1 영역과 3개 이하의 아미노산이 상이한 CDR1 영역,
    (b) BMS2h-572-633의 CDR2 영역과 3개 이하의 아미노산이 상이한 CDR2 영역,
    (c) BMS2h-572-633의 CDR3 영역과 3개 이하의 아미노산이 상이한 CDR3 영역,
    (d) BMS2h-572-633의 FR1 영역과 3개 이하의 아미노산이 상이한 FR1 영역,
    (e) BMS2h-572-633의 FR2 영역과 3개 이하의 아미노산이 상이한 FR2 영역,
    (f) BMS2h-572-633의 FR3 영역과 3개 이하의 아미노산이 상이한 FR3 영역, 및
    (g) BMS2h-572-633의 FR4 영역과 3개 이하의 아미노산이 상이한 FR4 영역
    을 포함하며,
    100 pM 내지 100 nM의 EC50으로 CD40에 대한 CD40L의 결합을 억제하는 단리된 항체 폴리펩티드.
  2. 제1항에 있어서, 제1 가변 도메인의 아미노산 서열이
    (a) BMS2h-572-633의 CDR1 영역과 3개 이하의 아미노산이 상이한 CDR1 영역,
    (b) BMS2h-572-633의 CDR2 영역과 3개 이하의 아미노산이 상이한 CDR2 영역, 및
    (c) BMS2h-572-633의 CDR3 영역과 3개 이하의 아미노산이 상이한 CDR3 영역
    을 포함하는 것인 항체 폴리펩티드.
  3. 제1항에 있어서, 제1 가변 도메인의 아미노산 서열이 BMS2h-572-633의 아미노산 서열과 10개 이하의 아미노산이 상이한 것인 항체 폴리펩티드.
  4. 제3항에 있어서, 제1 가변 도메인의 아미노산 서열이 BMS2h-572-633의 아미노산 서열과 5개 이하의 아미노산이 상이한 것인 항체 폴리펩티드.
  5. 제4항에 있어서, 제1 가변 도메인의 아미노산 서열이 BMS2h-572-633의 아미노산 서열과 2개 이하의 아미노산이 상이한 것인 항체 폴리펩티드.
  6. 제5항에 있어서, 제1 가변 도메인이 BMS2h-572-633의 아미노산 서열과 1개의 아미노산이 상이한 것인 항체 폴리펩티드.
  7. 제1항에 있어서, BMS2h-572의 계통 군으로부터 선택되며, 제1 가변 도메인의 아미노산 서열이
    (a) 서열 Trp-X1-Leu-Met-Gly (서열 2)을 갖는 CDR1 영역 (여기서 X1은 Glu 또는 Gln임);
    (b) 서열 Gly-Ile-Glu-Gly-Pro-Gly-Asp-Val-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly (서열 3)을 갖는 CDR2 영역; 및
    (c) 서열 Lys-X2-Y2-Z2-Ser-Asp-Tyr (서열 4)을 갖는 CDR3 영역 (여기서 X2는 Asp 또는 Glu이고, Y2는 Ala 또는 Ser이고, Z2는 Lys, Asn, 또는 Arg임)
    을 추가로 포함하는 것인 항체 폴리펩티드.
  8. 제7항에 있어서, 제1 가변 도메인의 아미노산 서열이
    (a) 서열 Glu-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly-Leu-Val-Gln-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Asn (서열 5)을 갖는 FR1 영역;
    (b) 서열 Trp-X1-Arg-Gln-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Trp-Val-Ser (서열 6)을 갖는 FR2 영역 (여기서 X1은 Ala 또는 Val임);
    (c) 서열 Arg-Thr-Phe-Ile-Ser-Arg-Asp-Asn-Ser-Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-Ala-Val-Tyr-Tyr-Cys-Val-Lys-Val-Gly (서열 7)을 갖는 FR3 영역; 및
    (d) 서열 Arg-Gly-Gln-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser (서열 8)을 갖는 FR4 영역
    을 추가로 포함하는 것인 항체 폴리펩티드.
  9. 제1항에 있어서, 제1 가변 도메인이 BMS2h-572-633의 아미노산 서열을 포함하는 것인 항체 폴리펩티드.
  10. 제1항 내지 제9항 중 어느 한 항에 있어서, 도메인 항체 (dAb)인 항체 폴리펩티드.
  11. 제1항 내지 제9항 중 어느 한 항에 있어서, 제1 가변 도메인 및 Fc 도메인을 포함하는 융합 폴리펩티드인 항체 폴리펩티드.
  12. 제11항에 있어서, 융합 폴리펩티드가 IgG4 Fc 도메인을 포함하는 것인 융합 폴리펩티드.
  13. 제11항에 있어서, 융합 폴리펩티드가 IgG1 Fc 도메인을 포함하는 것인 융합 폴리펩티드.
  14. 제11항에 있어서, 융합 폴리펩티드가 CT-긴 도메인을 포함하는 것인 융합 폴리펩티드.
  15. 제11항에 있어서, 융합 폴리펩티드가 CT-짧은 도메인을 포함하는 것인 융합 폴리펩티드.
  16. 제11항에 있어서, 융합 폴리펩티드가 N297Q 긴 Fc 도메인을 포함하는 것인 융합 폴리펩티드.
  17. 제11항에 있어서, 융합 폴리펩티드가 N297Q 짧은 Fc 도메인을 포함하는 것인 융합 폴리펩티드.
  18. 제1항 내지 제9항 중 어느 한 항에 있어서, 제2 항원에 특이적으로 결합하는 제2 가변 도메인을 추가로 포함하며, 여기서 제2 항원은 인간 CD40L 이외의 다른 항원인 항체 폴리펩티드.
  19. 제18항에 있어서, 제2 항원이 분화 클러스터 (CD) 분자 또는 주요 조직적합성 복합체 (MHC) 클래스 II 분자인 항체 폴리펩티드.
  20. 제18항에 있어서, 제2 항원이 혈청 알부민 (SA)인 항체 폴리펩티드.
  21. 제1항 내지 제20항 중 어느 한 항의 항체 폴리펩티드를 코딩하는 핵산.
  22. 제21항의 핵산을 포함하는 벡터.
  23. 제22항의 벡터를 포함하는 단리된 숙주 세포.
  24. 치료 유효량의 제1항의 항체 폴리펩티드 및 제약상 허용되는 담체를 포함하는 제약 조성물.
  25. 제24항에 있어서, 면역억제/면역조절제 및/또는 항염증제를 추가로 포함하는 제약 조성물.
  26. 면역 질환이 존재하거나 발생할 위험이 있는 환자의 치료를 위한 의약의 제조에 있어서, 제1항 내지 제20항 중 어느 한 항에 따른 단리된 항체 폴리펩티드의 용도.
  27. 제26항에 있어서, 단리된 항체 폴리펩티드가 면역억제/면역조절제 및/또는 항염증제와 조합하여 투여되는 것인 용도.
  28. 제26항에 있어서, 면역 질환이 자가면역 질환 또는 이식편-관련 질환인 용도.
  29. 제26항에 있어서, 면역 질환이 이식편-관련 질환인 용도.
  30. 제29항에 있어서, 이식편-관련 질환이 실질 기관, 조직 및/또는 세포 이식 거부를 포함하는 것인 용도.
  31. 제29항에 있어서, 이식편-관련 질환이 이식편 대 숙주 질환 (GVHD)인 용도.
  32. 제29항에 있어서, 이식편-관련 질환이 급성 이식 거부인 용도.
  33. 제29항에 있어서, 이식편-관련 질환이 만성 이식 거부인 용도.
  34. 제29항에 있어서, 단리된 항체 폴리펩티드가 CTLA4 돌연변이체 분자와 공투여되는 것인 용도.
  35. 제34항에 있어서, CTLA4 돌연변이체 분자가 L104EA29Y-Ig (벨라타셉트)인 용도.
  36. 제26항에 있어서, 면역 질환이 애디슨병(Addison's disease), 알레르기, 강직성 척추염, 천식, 아테롬성동맥경화증, 귀의 자가면역 질환, 눈의 자가면역 질환, 자가면역 간염, 자가면역 이하선염, 결장염, 관상동맥 심장 질환, 크론병(Crohn's disease), 제1형 및/또는 제2형 당뇨병을 포함하는 당뇨병, 부고환염, 사구체신염, 그레이브스병(Graves' disease), 길랑-바레(Guillain-Barre) 증후군, 하시모토병(Hashimoto's disease), 용혈성 빈혈, 특발성 혈소판감소성 자반증, 염증성 장 질환, 재조합 약물 제품에 대한 면역 반응, 전신 홍반성 루푸스, 남성 불임증, 다발성 경화증, 중증 근무력증, 천포창, 건선, 류마티스성 열, 류마티스 관절염, 사르코이드증, 경피증, 쇼그렌(Sjogren) 증후군, 척추관절병증, 갑상선염, 이식 거부, 혈관염, AIDS, 아토피성 알레르기, 기관지 천식, 습진, 나병, 정신분열증, 유전성 우울증, 만성 피로 증후군, 알츠하이머병(Alzheimer's disease), 파킨슨병(Parkinson's disease), 심근 경색, 졸중, 자폐증, 간질, 아르투스(Arthus) 현상, 아나필락시스, 알콜 중독, 및 약물 중독으로 이루어진 군으로부터 선택되는 것인 용도.
  37. 제26항에 있어서, 면역 질환이 중증 근무력증, 특발성 혈소판감소성 자반증, 및 전신 경화증으로 이루어진 군으로부터 선택되는 것인 용도.
  38. 제1 가변 도메인을 포함하고, 서열 1의 아미노산 서열을 포함하는 인간 CD40L에 특이적으로 결합하며, BMS2h-572-633의 결합과 경쟁하고, 100 pM 내지 100 nM의 EC50으로 CD40에 대한 CD40L의 결합을 억제하는 단리된 항체 폴리펩티드.
  39. 제38항에 있어서, 제1 가변 도메인이 BMS2h-572, BMS2h-719, BMS2h-503, 및 BMS2h-116으로 이루어진 계통 군으로부터 선택된 하나의 항체 폴리펩티드의 아미노산 서열을 포함하는 것인 단리된 항체 폴리펩티드.
  40. (없음).
  41. 제39항에 있어서, 제1 가변 도메인이 BMS2h-572-6, BMS2h-572-608, BMS2h-572-614, BMS2h-572-619, BMS2h-572-633, BMS2h-572-634, BMS2h-572-635, BMS2h-719-2, BMS2h-719-202, BMS2h-719-203, BMS2h-719-213, BMS2h-719-214, BMS2h-719-215, BMS2h-719-218, BMS2h-719-225, BMS2h-503-1, BMS2h-503-2, BMS2h-116-1312, BMS2h-116-1313, 또는 BMS2h-116-1320에 적어도 95% 동일한 아미노산 서열을 포함하는 것인 단리된 항체 폴리펩티드.
  42. 제40항에 있어서, 제1 가변 도메인이 BMS2h-572-6, BMS2h-572-608, BMS2h-572-614, BMS2h-572-619, BMS2h-572-633, BMS2h-572-634, BMS2h-572-635, BMS2h-719-2, BMS2h-719-202, BMS2h-719-203, BMS2h-719-213, BMS2h-719-214, BMS2h-719-215, BMS2h-719-218, BMS2h-719-225, BMS2h-503-1, BMS2h-503-2, BMS2h-116-1312, BMS2h-116-1313, 또는 BMS2h-116-1320의 아미노산 서열을 포함하는 것인 단리된 항체 폴리펩티드.
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