MX363638B - Anticuerpos que se unen a il - 4 y/o il - 13 y sus usos. - Google Patents

Anticuerpos que se unen a il - 4 y/o il - 13 y sus usos.

Info

Publication number
MX363638B
MX363638B MX2012002055A MX2012002055A MX363638B MX 363638 B MX363638 B MX 363638B MX 2012002055 A MX2012002055 A MX 2012002055A MX 2012002055 A MX2012002055 A MX 2012002055A MX 363638 B MX363638 B MX 363638B
Authority
MX
Mexico
Prior art keywords
antibodies
bind
fragments
novel
dermatitis
Prior art date
Application number
MX2012002055A
Other languages
English (en)
Inventor
Kruip Jochen
Mikol Vincent
Rao Ercole
Li Danxi
Davison Matthew
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39313041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX363638(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX363638B publication Critical patent/MX363638B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La presente invención se refiere a nuevos anticuerpos anti-IL-4 y IL-13 humanizados y a fragmentos de los mismos, y a nuevos anticuerpos biespecíficos y fragmentos de los mismos que se unen específicamente a IL-4 y a IL-13. La invención también incluye usos de los anticuerpos para tratar o prevenir enfermedades o trastornos mediados por IL-4 y/o IL-13, incluyendo asma alérgica y dermatitis.
MX2012002055A 2007-10-15 2008-10-14 Anticuerpos que se unen a il - 4 y/o il - 13 y sus usos. MX363638B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07291259A EP2050764A1 (en) 2007-10-15 2007-10-15 Novel polyvalent bispecific antibody format and uses thereof
US3712808P 2008-03-17 2008-03-17
PCT/US2008/079787 WO2009052081A2 (en) 2007-10-15 2008-10-14 Antibodies that bind il-4 and/or il-13 and their uses

Publications (1)

Publication Number Publication Date
MX363638B true MX363638B (es) 2019-03-28

Family

ID=39313041

Family Applications (6)

Application Number Title Priority Date Filing Date
MX2012002055A MX363638B (es) 2007-10-15 2008-10-14 Anticuerpos que se unen a il - 4 y/o il - 13 y sus usos.
MX2012002053A MX354150B (es) 2007-10-15 2008-10-14 Anticuerpos que se unen a il - 4 y/o il - 13 y sus usos.
MX2012010172A MX363901B (es) 2007-10-15 2008-10-14 Anticuerpos que se unen a il-4 y/o il-13 y sus usos.
MX2010003290A MX2010003290A (es) 2007-10-15 2008-10-14 Anticuerpos que se unen a il-4 y/o il-13 y sus usos.
MX2012010171A MX363634B (es) 2007-10-15 2008-10-14 Anticuerpos que se unen a il-4 y/o il-13 y sus usos.
MX2012002056A MX354666B (es) 2007-10-15 2010-03-25 Anticuerpos que se unen a il - 4 y/o - 13 y sus usos.

Family Applications After (5)

Application Number Title Priority Date Filing Date
MX2012002053A MX354150B (es) 2007-10-15 2008-10-14 Anticuerpos que se unen a il - 4 y/o il - 13 y sus usos.
MX2012010172A MX363901B (es) 2007-10-15 2008-10-14 Anticuerpos que se unen a il-4 y/o il-13 y sus usos.
MX2010003290A MX2010003290A (es) 2007-10-15 2008-10-14 Anticuerpos que se unen a il-4 y/o il-13 y sus usos.
MX2012010171A MX363634B (es) 2007-10-15 2008-10-14 Anticuerpos que se unen a il-4 y/o il-13 y sus usos.
MX2012002056A MX354666B (es) 2007-10-15 2010-03-25 Anticuerpos que se unen a il - 4 y/o - 13 y sus usos.

Country Status (43)

Country Link
US (17) US8388965B2 (es)
EP (12) EP2050764A1 (es)
JP (5) JP5858616B2 (es)
KR (5) KR101954596B1 (es)
CN (3) CN101827863B (es)
AR (3) AR068861A1 (es)
AU (5) AU2008312655B2 (es)
BR (1) BRPI0818677B8 (es)
CA (3) CA3071750C (es)
CL (4) CL2008003037A1 (es)
CR (5) CR11337A (es)
CY (5) CY1114987T1 (es)
DK (5) DK2573121T3 (es)
DO (3) DOP2010000109A (es)
ES (5) ES2679281T3 (es)
GT (1) GT201000067A (es)
HN (1) HN2010000710A (es)
HR (5) HRP20140150T1 (es)
HU (4) HUE038556T2 (es)
IL (2) IL205005A (es)
LT (4) LT2574629T (es)
MA (1) MA31838B1 (es)
MX (6) MX363638B (es)
MY (1) MY171214A (es)
NI (7) NI201000405A (es)
NO (2) NO2574629T3 (es)
NZ (3) NZ709353A (es)
PA (1) PA8799001A1 (es)
PE (1) PE20091382A1 (es)
PH (2) PH12013501032B1 (es)
PL (5) PL2573121T3 (es)
PT (5) PT2573121T (es)
RS (5) RS53175B (es)
RU (4) RU2580049C2 (es)
SG (4) SG10201602770UA (es)
SI (5) SI2574629T1 (es)
TN (1) TN2010000126A1 (es)
TR (2) TR201810005T4 (es)
TW (4) TWI616205B (es)
UA (2) UA104130C2 (es)
UY (1) UY31394A1 (es)
WO (1) WO2009052081A2 (es)
ZA (1) ZA201002069B (es)

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