ES2070172T3 - Procedimiento para producir proteinas mediante adn recombinante. - Google Patents
Procedimiento para producir proteinas mediante adn recombinante.Info
- Publication number
- ES2070172T3 ES2070172T3 ES89303767T ES89303767T ES2070172T3 ES 2070172 T3 ES2070172 T3 ES 2070172T3 ES 89303767 T ES89303767 T ES 89303767T ES 89303767 T ES89303767 T ES 89303767T ES 2070172 T3 ES2070172 T3 ES 2070172T3
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- recombinant dna
- producing proteins
- host cell
- synthesised
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
LA PRESENTE INVENCION PREVEE UN METODO PARA LA PRODUCCION DE FRAGMENTOS FV QUE COMPRENDE: TRANSFORMACION DE UNA CELULA EUCARIOTICA CON UN VECTOR DE EXPRESION AUCARIOTICO QUE COMPRENDE UN OPERON CON UNA SECUENCIA DE DNA QUE CODIFICA PARA UN DOMINIO VARIABLE SOLAMENTE DE UN ANTICUERPO DE CADENA LIGERA O PESADA. CULTIVO DE LA CELULA HUESPED TRANSFORMADA BAJO CONDICIONES QUE CAUSAN LA PROTEINA CODIFICADA POR LA SECUENCIA DE DNA QUE SE VA A SINTETIZAR, Y RECOLECCION DE LA PROTEINA SINTETIZADA. FIG.1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888809050A GB8809050D0 (en) | 1988-04-16 | 1988-04-16 | Expression of antibody heavy & light chain variable domains as an fv-fragment |
GB888811342A GB8811342D0 (en) | 1988-05-13 | 1988-05-13 | Expression of antibody heavy & light chain variable domains as active hetero-dimer in myeloma cells |
GB888820284A GB8820284D0 (en) | 1988-08-26 | 1988-08-26 | Method for producing recombinant dna proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2070172T3 true ES2070172T3 (es) | 1995-06-01 |
Family
ID=27263864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89303767T Expired - Lifetime ES2070172T3 (es) | 1988-04-16 | 1989-04-17 | Procedimiento para producir proteinas mediante adn recombinante. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0338745B1 (es) |
JP (2) | JP3105898B2 (es) |
AT (1) | ATE119198T1 (es) |
AU (1) | AU627183B2 (es) |
CA (1) | CA1341411C (es) |
DE (1) | DE68921364T2 (es) |
ES (1) | ES2070172T3 (es) |
GR (1) | GR3015248T3 (es) |
WO (1) | WO1989009825A1 (es) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT92900A (pt) * | 1989-01-24 | 1990-07-31 | Sistema de vectores de expressao para a producao de anticorpos monoclonais quimericos | |
GB9021671D0 (en) * | 1990-10-05 | 1990-11-21 | Unilever Plc | Delivery of agents |
GB9012995D0 (en) * | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
US5571894A (en) * | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
AU662311B2 (en) | 1991-02-05 | 1995-08-31 | Novartis Ag | Recombinant antibodies specific for a growth factor receptor |
US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US5939531A (en) * | 1991-07-15 | 1999-08-17 | Novartis Corp. | Recombinant antibodies specific for a growth factor receptor |
EP0861893A3 (en) * | 1991-09-19 | 1999-11-10 | Genentech, Inc. | High level expression of immunoglobulin polypeptides |
US6838254B1 (en) | 1993-04-29 | 2005-01-04 | Conopco, Inc. | Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae |
US5747654A (en) * | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
JPH11513669A (ja) * | 1995-10-13 | 1999-11-24 | アメリカ合衆国 | ジスルフィド安定化抗体フラグメントを含む免疫毒素 |
DE69627685T2 (de) * | 1995-10-20 | 2004-01-29 | Novartis Ag | Verfahren zur herstellung eines einkettigen fv antikörperfragments |
CA2257357C (en) | 1996-06-07 | 2010-04-13 | Neorx Corporation | Humanized antibodies with modified glycosylation |
JP2000164361A (ja) | 1998-11-25 | 2000-06-16 | Tdk Corp | 有機el素子 |
JP2003520195A (ja) | 1999-05-14 | 2003-07-02 | イムクローン システムズ インコーポレイティド | 上皮成長因子受容体アンタゴニストによる難治性ヒト腫瘍の処理 |
US7740841B1 (en) | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
IL152825A (en) | 2000-05-16 | 2009-07-20 | Univ Jefferson | Rabies virus-specific neutralizing human monoclonal antibodies and nucleic acids and related methods |
US7071319B2 (en) | 2000-05-16 | 2006-07-04 | Thomas Jefferson University | Recombinant antibodies, and compositions and methods for making and using the same |
SI2508596T1 (sl) | 2002-02-21 | 2016-01-29 | Institute Of Virology Slovak Academy Of Sciences | Monoklonska protitelesa, specifična za MN/CA IX, proizvedena iz MN/CA IX deficientnih miši, in postopki uporabe |
DK2308507T3 (da) | 2002-07-19 | 2015-04-20 | Beth Israel Hospital | Fremgangsmåder til behandling af præeklampsi |
US7435419B2 (en) | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
WO2005016970A2 (en) | 2003-05-01 | 2005-02-24 | Imclone Systems Incorporated | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
CA2560305C (en) | 2004-03-19 | 2016-07-05 | Imclone Systems Incorporated | Human anti-epidermal growth factor receptor antibody |
CA2581336C (en) | 2004-09-24 | 2022-10-04 | S. Ananth Karumanchi | Diagnosis of pregnancy-related hypertensive disorder by measurement of soluble endoglin |
CN102397542B (zh) | 2004-11-18 | 2014-05-07 | 英克隆有限责任公司 | 抗血管内皮生长因子受体-1的抗体 |
EP1812064A4 (en) | 2004-11-19 | 2009-07-08 | Cornell Res Foundation Inc | USE OF ENDOTHELIAL VASCULAR GROWTH FACTOR RECEPTOR CELLS IN THE TREATMENT AND MONITORING OF CANCER AND IN THE SCREENING OF CHEMOTHERAPEUTIC AGENTS |
BRPI0611984A2 (pt) | 2005-06-17 | 2009-07-07 | Imclone Systems Inc | uso de anticorpos igf-ir para fabricação de um medicamento para tratar um tumor ósseo |
BRPI0617057A2 (pt) | 2005-08-30 | 2011-07-12 | Univ Miami | anticorpo isolado, toxina especìfica para receptor de fator de necrose tumoral 25 (tnfr25), método para ativar o receptor de fator de necrose tumoral 25 (tnfr25), método para inibir a sinalização do receptor de fator de necrose tumoral 25 (tnfr25) numa célula, vacina antitumoral, método para imunizar um paciente contra tumor, método para tratar cáncer num paciente, método para tratar e/ou prevenir inflamação intestinal, composição terapêutica para a facilitação de um transplante de órgão, método para transplantar um tecido de um doador para um hospedeiro, método para inibir a expressão clonal de uma população de células t cd8 cognatas, método para tratar e/ou prevenir inflamação pulmonar, antagonista de tnfr25 isolado, composição e vetor de expressão |
AU2007274738B2 (en) | 2006-07-18 | 2013-11-28 | Sanofi-Aventis | Antagonist antibody against EphA2 for the treatment of cancer |
EP1914242A1 (en) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
KR100883430B1 (ko) | 2007-06-13 | 2009-02-12 | 한국생명공학연구원 | 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도 |
UA117446C2 (uk) | 2007-08-29 | 2018-08-10 | Санофі-Авентіс | Гуманізоване антитіло до cxcr5 |
EP2050764A1 (en) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Novel polyvalent bispecific antibody format and uses thereof |
AU2009222998B2 (en) | 2008-03-12 | 2013-05-23 | Imclone Llc | Anti-TYRP1 antibodies |
US8163497B2 (en) | 2008-09-07 | 2012-04-24 | Glyconex Inc. | Anti-extended type I glycosphingolipid antibody, derivatives thereof and use |
WO2011022472A2 (en) | 2009-08-18 | 2011-02-24 | President And Fellows Of Harvard College | Methods and compositions for the treatment of proliferative and pathogenic diseases |
UY32914A (es) | 2009-10-02 | 2011-04-29 | Sanofi Aventis | Anticuerpos que se usan específicamente al receptor epha2 |
MX341687B (es) | 2010-02-10 | 2016-08-30 | Immunogen Inc | "anticuerpos cd20 y su utilización". |
CN102844050B (zh) | 2010-02-19 | 2019-02-05 | 康奈尔大学 | 自身免疫性脱髓鞘疾病及其它自身免疫疾病或炎性疾病的治疗方法 |
AR080698A1 (es) | 2010-04-01 | 2012-05-02 | Imclone Llc | Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e |
WO2011145085A2 (en) | 2010-05-21 | 2011-11-24 | Procognia (Israel) Ltd | Novel antibodies and methods of use for the treatment and diagnosis of cancer |
EP3235508B1 (en) | 2011-03-16 | 2020-12-30 | Sanofi | Compositions comprising a dual v region antibody-like protein |
US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
TW201628647A (zh) | 2014-06-27 | 2016-08-16 | 賽諾菲公司 | 抗-il4-il13雙特異性抗體 |
US20180230218A1 (en) | 2017-01-04 | 2018-08-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
TWI808963B (zh) | 2017-03-22 | 2023-07-21 | 法商賽諾菲公司 | 使用人類化抗cxcr5抗體治療狼瘡 |
WO2019207159A1 (en) | 2018-04-27 | 2019-10-31 | Fondazione Ebri Rita Levi-Montalcini | Antibody directed against a tau-derived neurotoxic peptide and uses thereof |
WO2019217450A1 (en) | 2018-05-08 | 2019-11-14 | Rhode Island Hospital | Anti-chi3l1 antibodies for the detection and/or treatment of nonalcoholic fattly liver disease/nonalcoholic steatohepatitis and subsequent complications |
WO2020014306A1 (en) | 2018-07-10 | 2020-01-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
US11827671B2 (en) | 2019-05-24 | 2023-11-28 | Sanofi | Methods for treating systemic sclerosis |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0088994B1 (en) * | 1982-03-15 | 1991-06-19 | Schering Corporation | Hybrid dna, binding composition prepared thereby and processes therefor |
GB8607679D0 (en) * | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
WO1988001649A1 (en) * | 1986-09-02 | 1988-03-10 | Genex Corporation | Single polypeptide chain binding molecules |
-
1989
- 1989-04-17 JP JP01504561A patent/JP3105898B2/ja not_active Expired - Lifetime
- 1989-04-17 EP EP89303767A patent/EP0338745B1/en not_active Expired - Lifetime
- 1989-04-17 CA CA000596914A patent/CA1341411C/en not_active Expired - Fee Related
- 1989-04-17 DE DE68921364T patent/DE68921364T2/de not_active Expired - Fee Related
- 1989-04-17 AT AT89303767T patent/ATE119198T1/de active
- 1989-04-17 ES ES89303767T patent/ES2070172T3/es not_active Expired - Lifetime
- 1989-04-17 AU AU35364/89A patent/AU627183B2/en not_active Ceased
- 1989-04-17 WO PCT/GB1989/000399 patent/WO1989009825A1/en unknown
-
1995
- 1995-03-02 GR GR940403951T patent/GR3015248T3/el unknown
-
1998
- 1998-11-12 JP JP10322472A patent/JPH11225758A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP3105898B2 (ja) | 2000-11-06 |
JPH03500005A (ja) | 1991-01-10 |
JPH11225758A (ja) | 1999-08-24 |
WO1989009825A1 (en) | 1989-10-19 |
AU3536489A (en) | 1989-11-03 |
EP0338745A1 (en) | 1989-10-25 |
DE68921364T2 (de) | 1995-06-29 |
CA1341411C (en) | 2002-12-17 |
DE68921364D1 (de) | 1995-04-06 |
ATE119198T1 (de) | 1995-03-15 |
EP0338745B1 (en) | 1995-03-01 |
GR3015248T3 (en) | 1995-06-30 |
AU627183B2 (en) | 1992-08-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2070172T3 (es) | Procedimiento para producir proteinas mediante adn recombinante. | |
DK368588A (da) | Bindingsmolekyler med en enkelt polypeptidkaede | |
GB2137631B (en) | Multichain polypeptides and processes for their production | |
PT699755E (pt) | Metodo para obtencao de imunoglobulinas modificadas com imunogenicidade reduzida de dominios variaveis de anticorpos de murideo composicoes que as contem | |
PT990044E (pt) | Metodo para evolucao molecular in vitro da funcao de proteinas | |
FI961251A0 (fi) | Ihmisten metabotrooppiset glutamaattireseptorialatyypit(HMR4, HMR6, HMR7)ja niihin liittyvät DNA-yhdisteet | |
ATE365800T1 (de) | Therapeutische verwendungen von il-17 homologe polypeptide | |
DE3587524T2 (de) | Herstellung von chimären antikörpern. | |
ES2165851T3 (es) | Proteinas multivalentes que se unen a antigenos. | |
EA200000216A1 (ru) | Белки, связывающие интерлейкин-18, их получение и применение | |
PT83761B (pt) | Metodo para a producao de interleuquina-4 de mamifero | |
DK1246917T3 (da) | Humane Stra6-polypeptider | |
ES2114064T3 (es) | Inmunoanalisis para la deteccion de colageno o fragmentos de colageno. | |
ATE417112T1 (de) | Steigerung der immunantwort unter verwendung von zielgerichteten molekülen | |
FI102383B1 (fi) | Menetelmä ja plasmidi modifioidun PE40-domeenia sisältävän hybridiproteiinin valmistamiseksi | |
DE69634757D1 (de) | Vektor zur expression von n-terminal verlängerten proteinen in hefezellen | |
HUP9801330A2 (hu) | Új PKA-kötő fehérjék és alkalmazásuk | |
DK0422217T3 (da) | Human, rekombinant, placental ribonucleaseinhibitor og fremgangsmåde til produktion | |
EP0688224A4 (en) | MUTANT PROTEIN, METHODS AND MATERIALS USED FOR ITS MANUFACTURE AND USE | |
WO2000055192A3 (de) | Hämocyanin und dafür kodierende nukleinsäuresequenz | |
DE69721629D1 (de) | An Nukleinsäure gebundenes Polypeptid, Verfahren zur Herstellung eines an Nukleinsäure gebundenen Polypeptides und Immunoassay, in dem dieses Polypeptid Verwendung findet | |
DK1249491T3 (da) | Nucleinsyre, der opformeres i humane tumorer samt beslægtede materialer og fremgangsmåder | |
DK1241185T3 (da) | Nucleinsyrer, der er opformeret i humane tumorer, samt beslægtede materialer og fremgangsmåder | |
PT1217006E (pt) | Polipeptidos e acidos nucleicos que os codificam |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 338745 Country of ref document: ES |