ATE119198T1 - Verfahren zur herstellung von proteinen mittels rekombinanter dna. - Google Patents
Verfahren zur herstellung von proteinen mittels rekombinanter dna.Info
- Publication number
- ATE119198T1 ATE119198T1 AT89303767T AT89303767T ATE119198T1 AT E119198 T1 ATE119198 T1 AT E119198T1 AT 89303767 T AT89303767 T AT 89303767T AT 89303767 T AT89303767 T AT 89303767T AT E119198 T1 ATE119198 T1 AT E119198T1
- Authority
- AT
- Austria
- Prior art keywords
- recombinant dna
- producing proteins
- host cell
- synthesised
- dna sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888809050A GB8809050D0 (en) | 1988-04-16 | 1988-04-16 | Expression of antibody heavy & light chain variable domains as an fv-fragment |
GB888811342A GB8811342D0 (en) | 1988-05-13 | 1988-05-13 | Expression of antibody heavy & light chain variable domains as active hetero-dimer in myeloma cells |
GB888820284A GB8820284D0 (en) | 1988-08-26 | 1988-08-26 | Method for producing recombinant dna proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE119198T1 true ATE119198T1 (de) | 1995-03-15 |
Family
ID=27263864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89303767T ATE119198T1 (de) | 1988-04-16 | 1989-04-17 | Verfahren zur herstellung von proteinen mittels rekombinanter dna. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0338745B1 (de) |
JP (2) | JP3105898B2 (de) |
AT (1) | ATE119198T1 (de) |
AU (1) | AU627183B2 (de) |
CA (1) | CA1341411C (de) |
DE (1) | DE68921364T2 (de) |
ES (1) | ES2070172T3 (de) |
GR (1) | GR3015248T3 (de) |
WO (1) | WO1989009825A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT92900A (pt) * | 1989-01-24 | 1990-07-31 | Sistema de vectores de expressao para a producao de anticorpos monoclonais quimericos | |
GB9021671D0 (en) * | 1990-10-05 | 1990-11-21 | Unilever Plc | Delivery of agents |
GB9012995D0 (en) * | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
AU662311B2 (en) | 1991-02-05 | 1995-08-31 | Novartis Ag | Recombinant antibodies specific for a growth factor receptor |
US5571894A (en) * | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
EP1400536A1 (de) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Verfahren zur Herstellung humanisierter Antikörper |
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
US5939531A (en) * | 1991-07-15 | 1999-08-17 | Novartis Corp. | Recombinant antibodies specific for a growth factor receptor |
EP0861893A3 (de) * | 1991-09-19 | 1999-11-10 | Genentech, Inc. | Hohe expression von immunglobulinen |
AU6796094A (en) | 1993-04-29 | 1994-11-21 | Raymond Hamers | Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of (camelidae) |
US5747654A (en) | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
US6010861A (en) * | 1994-08-03 | 2000-01-04 | Dgi Biotechnologies, Llc | Target specific screens and their use for discovering small organic molecular pharmacophores |
AU706056B2 (en) * | 1995-10-13 | 1999-06-10 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Immunotoxin containing a disulfide-stabilized antibody fragment |
AU7288196A (en) * | 1995-10-20 | 1997-05-15 | Ciba-Geigy Ag | Process for the preparation of a single chain fv antibody fragment |
DE69724428T3 (de) | 1996-06-07 | 2009-07-23 | Poniard Pharmaceuticals, Inc., Seattle | Humanisierte antikörper die an das gleiche antigen wie antikörper nr-lu-13 binden und deren verwendung in "pretargeting" verfahren |
JP2000164361A (ja) | 1998-11-25 | 2000-06-16 | Tdk Corp | 有機el素子 |
EE200100603A (et) | 1999-05-14 | 2003-02-17 | Imclone Systems Incorporated | Inimese refraktaarsete kasvajate ravi epidermaalse kasvufaktori retseptori antagonistidega |
US7740841B1 (en) | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
CA2419148C (en) | 2000-05-16 | 2011-07-12 | Thomas Jefferson University | Rabies virus-specific neutralizing human monoclonal antibodies and nucleic acids and related methods |
US7071319B2 (en) | 2000-05-16 | 2006-07-04 | Thomas Jefferson University | Recombinant antibodies, and compositions and methods for making and using the same |
DK2508596T3 (en) | 2002-02-21 | 2015-10-19 | Inst Virology | MN / CA IX-specific monoclonal antibodies generated from MN / CA IX-poor mice, as well as methods of use. |
ES2534926T3 (es) | 2002-07-19 | 2015-04-30 | Beth Israel Deaconess Medical Center | Métodos para tratar la preeclampsia |
US7435419B2 (en) | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
ES2527871T3 (es) | 2003-05-01 | 2015-02-02 | Imclone Llc | Anticuerpos completamente humanos dirigidos contra el receptor del factor de crecimiento 1 similar a la insulina humana |
EP1735348B1 (de) | 2004-03-19 | 2012-06-20 | Imclone LLC | Humaner antikörper gegen den rezeptor des epidermalen wachstumsfaktors |
DE602005024850D1 (de) | 2004-09-24 | 2010-12-30 | Beth Israel Hospital | Verfahren zur diagnose und behandlung von schwangerschaftsskomplikationen |
CN101102791B (zh) | 2004-11-18 | 2011-12-14 | 英克隆有限责任公司 | 抗血管内皮生长因子受体-1的抗体 |
EP1812064A4 (de) | 2004-11-19 | 2009-07-08 | Cornell Res Foundation Inc | Verwendung vaskulärer endothelwachstumsfaktor-rezeptor-1+-zellen bei der behandlung und überwachung von krebs und beim screening bei chemotherapie |
BRPI0611984A2 (pt) | 2005-06-17 | 2009-07-07 | Imclone Systems Inc | uso de anticorpos igf-ir para fabricação de um medicamento para tratar um tumor ósseo |
CN101253199B (zh) | 2005-08-30 | 2019-06-14 | 迈阿密大学 | 免疫调节肿瘤坏死因子受体25(tnfr25)的激动剂、拮抗剂和免疫毒素 |
MY157757A (en) | 2006-07-18 | 2016-07-15 | Sanofi Aventis | Antagonist antibody against epha2 for the treatment of cancer |
EP1914242A1 (de) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Neue Antikörper gegen CD38 zur Behandlung von Krebs |
KR100883430B1 (ko) | 2007-06-13 | 2009-02-12 | 한국생명공학연구원 | 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도 |
NO2195023T3 (de) | 2007-08-29 | 2018-08-04 | ||
EP2050764A1 (de) | 2007-10-15 | 2009-04-22 | sanofi-aventis | Neues polyvalentes bispezifisches Antikörperformat und Verwendung |
MX2010010021A (es) | 2008-03-12 | 2011-02-15 | Imclone Llc | Anticuepos anti-tyrp1. |
AU2008361352B2 (en) | 2008-09-07 | 2013-05-09 | Glyconex Inc. | Anti-extended Type I glycosphingolipid antibody, derivatives thereof and use |
US9163086B2 (en) | 2009-08-18 | 2015-10-20 | President And Fellows Of Harvard College | Methods and compositions for the treatment of proliferative and pathogenic diseases |
TW201116297A (en) | 2009-10-02 | 2011-05-16 | Sanofi Aventis | Antibodies that specifically bind to the EphA2 receptor |
EP2533810B1 (de) | 2010-02-10 | 2016-10-12 | ImmunoGen, Inc. | Cd20-antikörper und ihre verwendung |
CN102844050B (zh) | 2010-02-19 | 2019-02-05 | 康奈尔大学 | 自身免疫性脱髓鞘疾病及其它自身免疫疾病或炎性疾病的治疗方法 |
AR080698A1 (es) | 2010-04-01 | 2012-05-02 | Imclone Llc | Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e |
WO2011145085A2 (en) | 2010-05-21 | 2011-11-24 | Procognia (Israel) Ltd | Novel antibodies and methods of use for the treatment and diagnosis of cancer |
EP3235508B1 (de) | 2011-03-16 | 2020-12-30 | Sanofi | Zubereitungen enthaltend ein antikörperähnliches protein mit dualer v-region |
US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
TW201628647A (zh) | 2014-06-27 | 2016-08-16 | 賽諾菲公司 | 抗-il4-il13雙特異性抗體 |
TW201825515A (zh) | 2017-01-04 | 2018-07-16 | 美商伊繆諾金公司 | Met抗體以及其免疫結合物及用途 |
TWI808963B (zh) | 2017-03-22 | 2023-07-21 | 法商賽諾菲公司 | 使用人類化抗cxcr5抗體治療狼瘡 |
US20210230255A1 (en) | 2018-04-27 | 2021-07-29 | Fondazione Ebri Rita Levi-Montalcini | Antibody directed against a tau-derived neurotoxic peptide and uses thereof |
US11155638B2 (en) | 2018-05-08 | 2021-10-26 | Rhode Island Hospital | Anti-CHI3L1 antibodies for the detection and/or treatment of nonalcoholic fattly liver disease/nonalcoholic steatonhepatitis and subsequent complications |
WO2020014306A1 (en) | 2018-07-10 | 2020-01-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
CN113891729A (zh) | 2019-05-24 | 2022-01-04 | 赛诺菲 | 治疗系统性硬化症的方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3382317D1 (de) * | 1982-03-15 | 1991-07-25 | Schering Corp | Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer. |
GB8607679D0 (en) * | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
DE3785186T2 (de) * | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
-
1989
- 1989-04-17 WO PCT/GB1989/000399 patent/WO1989009825A1/en unknown
- 1989-04-17 ES ES89303767T patent/ES2070172T3/es not_active Expired - Lifetime
- 1989-04-17 JP JP01504561A patent/JP3105898B2/ja not_active Expired - Lifetime
- 1989-04-17 CA CA000596914A patent/CA1341411C/en not_active Expired - Fee Related
- 1989-04-17 DE DE68921364T patent/DE68921364T2/de not_active Expired - Fee Related
- 1989-04-17 EP EP89303767A patent/EP0338745B1/de not_active Expired - Lifetime
- 1989-04-17 AU AU35364/89A patent/AU627183B2/en not_active Ceased
- 1989-04-17 AT AT89303767T patent/ATE119198T1/de active
-
1995
- 1995-03-02 GR GR940403951T patent/GR3015248T3/el unknown
-
1998
- 1998-11-12 JP JP10322472A patent/JPH11225758A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
GR3015248T3 (en) | 1995-06-30 |
JP3105898B2 (ja) | 2000-11-06 |
AU627183B2 (en) | 1992-08-20 |
DE68921364T2 (de) | 1995-06-29 |
WO1989009825A1 (en) | 1989-10-19 |
JPH03500005A (ja) | 1991-01-10 |
DE68921364D1 (de) | 1995-04-06 |
EP0338745B1 (de) | 1995-03-01 |
AU3536489A (en) | 1989-11-03 |
CA1341411C (en) | 2002-12-17 |
ES2070172T3 (es) | 1995-06-01 |
JPH11225758A (ja) | 1999-08-24 |
EP0338745A1 (de) | 1989-10-25 |
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