DE69627685T2 - Verfahren zur herstellung eines einkettigen fv antikörperfragments - Google Patents

Verfahren zur herstellung eines einkettigen fv antikörperfragments Download PDF

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Publication number
DE69627685T2
DE69627685T2 DE69627685T DE69627685T DE69627685T2 DE 69627685 T2 DE69627685 T2 DE 69627685T2 DE 69627685 T DE69627685 T DE 69627685T DE 69627685 T DE69627685 T DE 69627685T DE 69627685 T2 DE69627685 T2 DE 69627685T2
Authority
DE
Germany
Prior art keywords
single chain
producing
antibody
antibody molecules
antibody fragment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69627685T
Other languages
English (en)
Other versions
DE69627685D1 (de
Inventor
Titus Kretzschmar
Martin Geiser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE69627685D1 publication Critical patent/DE69627685D1/de
Publication of DE69627685T2 publication Critical patent/DE69627685T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69627685T 1995-10-20 1996-10-09 Verfahren zur herstellung eines einkettigen fv antikörperfragments Expired - Fee Related DE69627685T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95810652 1995-10-20
PCT/EP1996/004376 WO1997015601A1 (en) 1995-10-20 1996-10-09 Process for the preparation of a single chain fv antibody fragment

Publications (2)

Publication Number Publication Date
DE69627685D1 DE69627685D1 (de) 2003-05-28
DE69627685T2 true DE69627685T2 (de) 2004-01-29

Family

ID=8221808

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69627685T Expired - Fee Related DE69627685T2 (de) 1995-10-20 1996-10-09 Verfahren zur herstellung eines einkettigen fv antikörperfragments

Country Status (5)

Country Link
EP (1) EP0857177B1 (de)
AT (1) ATE238349T1 (de)
AU (1) AU7288196A (de)
DE (1) DE69627685T2 (de)
WO (1) WO1997015601A1 (de)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3105898B2 (ja) * 1988-04-16 2000-11-06 セルテック リミテッド 組換えｄｎａタンパクの製造方法
WO1991016353A1 (en) * 1990-04-23 1991-10-31 Corvas International N.V. Thrombus-specific antibody derivatives
GB9106185D0 (en) * 1991-03-22 1991-05-08 Wellcome Found Biological control agents
GB9114468D0 (en) * 1991-07-04 1991-08-21 Wellcome Found Antibody production
WO1993008300A1 (en) * 1991-10-18 1993-04-29 The University Of Calgary Expression-secretion vectors for the production of biologically active fv fragments
EP0618977A4 (en) * 1991-12-18 1997-02-12 Univ Calgary Expression-secretion vectors for the production of biologically active fv fragments.

Also Published As

Publication number Publication date
EP0857177A1 (de) 1998-08-12
WO1997015601A1 (en) 1997-05-01
AU7288196A (en) 1997-05-15
EP0857177B1 (de) 2003-04-23
ATE238349T1 (de) 2003-05-15
DE69627685D1 (de) 2003-05-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8339 Ceased/non-payment of the annual fee