HRP20181087T1 - Pripravak i postupak dijagnostike i liječenja bolesti povezanih s degeneracijom neurita - Google Patents
Pripravak i postupak dijagnostike i liječenja bolesti povezanih s degeneracijom neurita Download PDFInfo
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- HRP20181087T1 HRP20181087T1 HRP20181087TT HRP20181087T HRP20181087T1 HR P20181087 T1 HRP20181087 T1 HR P20181087T1 HR P20181087T T HRP20181087T T HR P20181087TT HR P20181087 T HRP20181087 T HR P20181087T HR P20181087 T1 HRP20181087 T1 HR P20181087T1
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- 230000007850 degeneration Effects 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 210000002241 neurite Anatomy 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
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- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0058—Antibodies
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- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
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- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
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- A61K51/1021—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against cytokines, e.g. growth factors, VEGF, TNF, lymphokines or interferons
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- C07K2317/565—Complementarity determining region [CDR]
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Claims (11)
1. Izolirano protutijelo monoklonske anti-odbojne vodljive molekule (RGMa) koje sadrži varijabilnu regiju teškog lanca koja sadrži regiju koja određuje komplementarnost (CDR) koja sadrži sekvencu aminokiseline SEQ ID NO:2, CDR2 koja sadrži sekvencu aminokiseline SEQ ID NO:3, i CDR3 koja sadrži sekvencu aminokiseline SEQ ID NO:4, i varijabilnu regiju laganog lanca koja sadrži CDR1 koja sadrži sekvencu aminokiseline SEQ ID NO:6, CDR2 koja sadrži sekvencu aminokiseline SEQ ID NO:7, i CDR3 koja sadrži sekvencu aminokiseline SEQ ID NO:8 ili SEQ ID NO:73.
2. Izolirano protutijelo monoklonske anti-RGMa prema zahtjevu 1, naznačeno time da CDR3 varijabilne regije laganog lanca sadrži sekvencu aminokiseline SEQ ID NO:73.
3. Izolirano protutijelo monoklonske anti-RGMa prema zahtjevu 1 ili zahtjevu 2, naznačeno time da protutijelo je ljudsko.
4. Izolirano protutijelo monoklonske anti-RGMa prema zahtjevu 1 ili zahtjevu 2, naznačeno time da protutijelo sadrži imunoglobulinsku konstantnu domenu teškog lanca za IgG izotip.
5. Izolirano protutijelo monoklonske anti-RGMa prema zahtjevu 4, naznačeno time da IgG izotip je ljudski IgG1 izotip.
6. Izolirano protutijelo monoklonske anti-RGMa prema zahtjevu 5, naznačeno time da ljudska IgG1 konstantna domena sadrži SEQ ID NO: 140, 141, 142, ili 143.
7. Izolirano protutijelo monoklonske anti-RGMa prema zahtjevu 5, naznačeno time da ljudska IgG1 konstantna domena sadrži SEQ ID NO:143.
8. Izolirano protutijelo monoklonske anti-RGMa prema zahtjevu 1 ili zahtjevu 2, naznačeno time da protutijelo sadrži konstantnu regiju lambda laganog lanca.
9. Izolirano protutijelo monoklonske anti-RGMa prema bilo kojem od zahtjeva 1-8, naznačeno time da protutijelo sadrži sekvencu laganog lanca kao što je prikazano u SEQ ID NO:146 i sekvencu teškog lanca kao što je prikazano u SEQ ID NO:147.
10. Anti-RGMa protutijelo prema bilo kojem od zahtjeva 1-9, naznačeno time da protutijelo nadalje obuhvaća sredstvo odabrano iz skupine koju čine: imuno adhezivna molekula, sredstvo za snimanje, te terapijsko sredstvo,
pri čemu je sredstvo za snimanje odabrano iz skupine koja sadrži radioobilježivač, enzim, fluorescentnu oznaku, svjetleću oznaku, bioluminiscentnu oznaku, magnetsku oznaku, i biotin, i
pri čemu je radioobilježivač odabran iz skupine koju čine 3H, 14C, 35S, 90Y, 99Tc, 111In, 125I, 131I, 177Lu, 166Ho, i 153Sm.
11. Farmaceutski pripravak naznačen time da sadrži anti-RGMa protutijelo prema bilo kojem od zahtjeva 1-9.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261591324P | 2012-01-27 | 2012-01-27 | |
PCT/US2013/023277 WO2013112922A1 (en) | 2012-01-27 | 2013-01-25 | Composition and method for diagnosis and treatment of diseases associated with neurite degeneration |
EP13703962.4A EP2807192B1 (en) | 2012-01-27 | 2013-01-25 | Composition and method for diagnosis and treatment of diseases associated with neurite degeneration |
Publications (1)
Publication Number | Publication Date |
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HRP20181087T1 true HRP20181087T1 (hr) | 2018-09-07 |
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HRP20181087TT HRP20181087T1 (hr) | 2012-01-27 | 2018-07-11 | Pripravak i postupak dijagnostike i liječenja bolesti povezanih s degeneracijom neurita |
Country Status (36)
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US (6) | US20130330347A1 (hr) |
EP (3) | EP2807192B1 (hr) |
JP (4) | JP6271441B2 (hr) |
KR (1) | KR102129234B1 (hr) |
CN (2) | CN104487455A (hr) |
AU (4) | AU2013211939C1 (hr) |
BR (1) | BR112014018592B1 (hr) |
CA (1) | CA2857967C (hr) |
CL (1) | CL2014001963A1 (hr) |
CO (1) | CO7020876A2 (hr) |
CR (1) | CR20140360A (hr) |
CY (1) | CY1120390T1 (hr) |
DK (1) | DK2807192T3 (hr) |
DO (1) | DOP2014000174A (hr) |
EC (1) | ECSP14010817A (hr) |
ES (1) | ES2676725T3 (hr) |
GT (1) | GT201400162A (hr) |
HK (1) | HK1198831A1 (hr) |
HR (1) | HRP20181087T1 (hr) |
HU (1) | HUE039611T2 (hr) |
IL (5) | IL297229A (hr) |
LT (1) | LT2807192T (hr) |
MX (2) | MX352772B (hr) |
MY (2) | MY176695A (hr) |
NZ (2) | NZ625403A (hr) |
PE (2) | PE20190907A1 (hr) |
PH (1) | PH12014501682A1 (hr) |
PL (1) | PL2807192T3 (hr) |
PT (1) | PT2807192T (hr) |
RS (1) | RS57603B1 (hr) |
RU (2) | RU2017145268A (hr) |
SG (3) | SG10202006762PA (hr) |
SI (1) | SI2807192T1 (hr) |
TR (1) | TR201809967T4 (hr) |
UA (1) | UA118083C2 (hr) |
WO (1) | WO2013112922A1 (hr) |
Families Citing this family (22)
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ES2562832T3 (es) * | 2009-12-08 | 2016-03-08 | Abbvie Deutschland Gmbh & Co Kg | Anticuerpos monoclonales contra la proteína RGM para su uso en el tratamiento de la degeneración de la capa de fibra nerviosa de la retina |
EP3252072A3 (en) | 2010-08-03 | 2018-03-14 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
LT2807192T (lt) * | 2012-01-27 | 2018-07-25 | AbbVie Deutschland GmbH & Co. KG | Kompozicijos ir būdai, skirti ligų, susijusių su neuritų degeneracija, diagnostikai ir gydymui |
BR112015012014A2 (pt) | 2012-12-04 | 2017-07-11 | Abbvie Inc | proteínas de ligação específicas duais penetrando a barreira hematoencefálica (bbb) |
JPWO2015025770A1 (ja) | 2013-08-19 | 2017-03-02 | 国立大学法人大阪大学 | 疼痛抑制物質のスクリーニング方法および疼痛の予防または治療用医薬組成物 |
US20160002343A1 (en) | 2014-06-11 | 2016-01-07 | Abbvie Inc. | Blood-brain barrier (bbb) penetrating dual specific binding proteins for treating brain and neurological diseases |
CN107076757A (zh) * | 2014-09-10 | 2017-08-18 | 艾伯维德国有限责任两合公司 | 基于RGMa片段的诊断测定 |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
GB201502447D0 (en) | 2015-02-13 | 2015-04-01 | Univ Liverpool | Method and apparatus for sample analysis |
MX2017013894A (es) * | 2015-04-28 | 2018-03-01 | Mitsubishi Tanabe Pharma Corp | Proteina de union a la molecula de guia repelente a (rgma) y su uso. |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
BR112018004867A2 (pt) * | 2015-09-11 | 2018-10-16 | Abbvie Deutschland | métodos para tratamento das formas recorrentes de esclerose múltipla |
WO2017161327A1 (en) * | 2016-03-17 | 2017-09-21 | Diazyme Laboratories, Inc. | Use of fusion proteins to improve the availability of antigenic peptide epitopes in immunoassays |
WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
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