PE20142168A1 - Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas - Google Patents

Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas

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Publication number
PE20142168A1
PE20142168A1 PE2014001182A PE2014001182A PE20142168A1 PE 20142168 A1 PE20142168 A1 PE 20142168A1 PE 2014001182 A PE2014001182 A PE 2014001182A PE 2014001182 A PE2014001182 A PE 2014001182A PE 20142168 A1 PE20142168 A1 PE 20142168A1
Authority
PE
Peru
Prior art keywords
neurites
degeneration
treatment
diagnosis
composition
Prior art date
Application number
PE2014001182A
Other languages
English (en)
Inventor
Bernhard Mueller
Lili Huang
Philip D Bardwell
Yuliya Kutskova
John Memmott
Original Assignee
AbbVie Deutschland GmbH and Co KG
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AbbVie Deutschland GmbH and Co KG, Abbvie Inc filed Critical AbbVie Deutschland GmbH and Co KG
Publication of PE20142168A1 publication Critical patent/PE20142168A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K49/0013—Luminescence
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    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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    • A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
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    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/54—F(ab')2
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
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    • G01N2800/285—Demyelinating diseases; Multipel sclerosis

Abstract

SE REFIERE A UN ANTICUERPO AISLADO QUE PUEDEN UNIRSE A LA MOLECULA DE GUIA REPULSIVA A (RGMA), CARACTERIZADOS PORQUE COMPRENDEN: a) UNA REGION DEL DOMINIO VARIABLE DE LA CADENA PESADA QUE TIENE UNA SECUENCIA DE AMINOACIDOS EN SEQ ID N� 1, 9, 17, ENTRE OTROS; b) UNA REGION DEL DOMINIO VARIABLE DE LA CADENA LIVIANA QUE TIENE UNA SECUENCIA DE AMINOACIDOS EN SEQ ID N� 5, 13, 21, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE TRASTORNO ASOCIADO A LA DEGENERACION DE LAS NEURITAS.
PE2014001182A 2012-01-27 2013-01-25 Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas PE20142168A1 (es)

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US201261591324P 2012-01-27 2012-01-27

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PE20142168A1 true PE20142168A1 (es) 2015-01-17

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PE2019000665A PE20190907A1 (es) 2012-01-27 2013-01-25 Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas
PE2014001182A PE20142168A1 (es) 2012-01-27 2013-01-25 Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas

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US (6) US20130330347A1 (es)
EP (3) EP2807192B1 (es)
JP (4) JP6271441B2 (es)
KR (1) KR102129234B1 (es)
CN (2) CN104487455A (es)
AU (4) AU2013211939C1 (es)
BR (1) BR112014018592B1 (es)
CA (1) CA2857967C (es)
CL (1) CL2014001963A1 (es)
CO (1) CO7020876A2 (es)
CR (1) CR20140360A (es)
CY (1) CY1120390T1 (es)
DK (1) DK2807192T3 (es)
DO (1) DOP2014000174A (es)
EC (1) ECSP14010817A (es)
ES (1) ES2676725T3 (es)
GT (1) GT201400162A (es)
HK (1) HK1198831A1 (es)
HR (1) HRP20181087T1 (es)
HU (1) HUE039611T2 (es)
IL (5) IL297229A (es)
LT (1) LT2807192T (es)
MX (2) MX352772B (es)
MY (2) MY176695A (es)
NZ (2) NZ625403A (es)
PE (2) PE20190907A1 (es)
PH (1) PH12014501682A1 (es)
PL (1) PL2807192T3 (es)
PT (1) PT2807192T (es)
RS (1) RS57603B1 (es)
RU (2) RU2017145268A (es)
SG (3) SG10202006762PA (es)
SI (1) SI2807192T1 (es)
TR (1) TR201809967T4 (es)
UA (1) UA118083C2 (es)
WO (1) WO2013112922A1 (es)

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