HRP20220891T1 - Protutijela, primjene i postupci - Google Patents
Protutijela, primjene i postupci Download PDFInfo
- Publication number
- HRP20220891T1 HRP20220891T1 HRP20220891TT HRP20220891T HRP20220891T1 HR P20220891 T1 HRP20220891 T1 HR P20220891T1 HR P20220891T T HRP20220891T T HR P20220891TT HR P20220891 T HRP20220891 T HR P20220891T HR P20220891 T1 HRP20220891 T1 HR P20220891T1
- Authority
- HR
- Croatia
- Prior art keywords
- antibody
- antigen
- binding fragment
- seq
- light chain
- Prior art date
Links
- 239000000427 antigen Substances 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 239000012634 fragment Substances 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 4
- 208000024908 graft versus host disease Diseases 0.000 claims 4
- 201000004624 Dermatitis Diseases 0.000 claims 2
- 238000013475 authorization Methods 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (17)
1. Protutijelo ili njegov fragment koji veže antigen koje se specifično veže na hOX40L, i inhibira vezanje hOX40L na hOX40, pri čemu protutijelo ili fragment koji veže antigen sadrži teški lanac i laki lanac i pri čemu teški lanac sadrži VH domenu koja sadrži sekvencu aminokiseline SEQ ID NO: 34, a laki lanac sadrži VL domenu koja sadrži sekvencu aminokiseline SEQ ID NO:48.
2. Protutijelo ili fragment koji veže antigen prema patentnom zahtjevu 1, naznačeno time što sadrži ljudsku gama 4 konstantnu regiju.
3. Protutijelo ili fragment koji veže antigen prema patentnom zahtjevu 2, naznačeno time što sadrži konstantnu regiju teškog lanca iz SEQ ID No: 128.
4. Protutijelo ili fragment koji veže antigen prema bilo kojem prethodnom patentnom zahtjevu, naznačeno time što protutijelo ili fragment koji veže antigen sadrži kapa laki lanac koji sadrži konstantnu regiju odabranu iz skupine koju čine sekvence aminokiselina konstantne regije lakog lanca iz SEQ ID Nos: 136, 138, 140, 142 i 144, naročito SEQ ID No:136.
5. Protutijelo prema bilo kojem prethodnom patentnom zahtjevu naznačeno time što protutijelo sadrži teški lanac i laki lanac, te aminokiselinska sekvenca teškog lanca sadrži sekvencu SEQ ID No:62 i aminokiselinska sekvenca lakog lanca sadrži sekvencu SEQ ID No:64.
6. Farmaceutski pripravak koji sadrži protutijelo ili fragment koji veže antigen kako je definirano u bilo kojem od zahtjeva 1 do 5, i farmaceutski prihvatljivu pomoćnu tvar, razrjeđivač ili nosač, po izboru formuliran za parenteralnu primjenu koja je odabrana od intravenske ili potkožne primjene.
7. Farmaceutski pripravak prema patentnom zahtjevu 6, naznačen time što se koristi u liječenju i/ili prevenciji bolesti presatka protiv domaćina (GvHD).
8. Farmaceutski pripravak prema patentnom zahtjevu 6, naznačen time što se koristi u liječenju i/ili prevenciji dermatitisa.
9. Komplet koji sadrži protutijelo ili fragment koji veže antigen kako je definirano u bilo kojem od zahtjeva 1 do 5, u kombinaciji s oznakom ili uputama za uporabu za liječenje i/ili prevenciju navedene bolesti ili stanja kod ljudi; izborno pri čemu naljepnica ili upute sadrže broj odobrenja za stavljanje u promet (npr. EMA broj autorizacije).
10. Komplet prema patentnom zahtjevu 9, naznačen time što nadalje sadrži uređaj za injektiranje, izborno uređaj za intravensku injekciju.
11. Protutijelo ili fragment koji veže antigen kako je definirano u bilo kojem od zahtjeva 1 do 5 naznačeno time što je za upotrebu u terapiji.
12. Protutijelo ili njegov fragment koji veže antigen kako je definirano u bilo kojem od zahtjeva 1 do 5, naznačeno time što je za upotrebu za liječenje ili prevenciju bolesti presatka protiv domaćina (GvHD).
13. Protutijelo ili njegov fragment koji veže antigen kako je definirano u bilo kojem od zahtjeva 1 do 5, naznačeno time što je za upotrebu za liječenje ili prevenciju dermatitisa.
14. Nukleinska kiselina koja kodira VH domenu i VL domenu protutijela ili fragmenta koji veže antigen kako je definirano u bilo kojem od zahtjeva 1 do 5.
15. Nukleinska kiselina koja kodira VH domenu protutijela ili fragmenta antigen koji veže antigen kako je definirano u bilo kojem od zahtjeva 1 do 5, i nukleinska kiselina koja kodira VL domenu protutijela ili fragmenta koji veže antigen kako je definirano u bilo kojem od zahtjeva 1 do 5.
16. Vektor naznačen time što sadrži nukleinsku kiselinu kako je definirana u zahtjevu 14 ili nukleinske kiseline kako su definirane u zahtjevu 15.
17. Stanica domaćina koja sadrži nukleinsku kiselinu kako je definirana u zahtjevu 14 ili nukleinske kiseline kako su definirane u zahtjevu 15, ili vektor kako je definiran u zahtjevu 16.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201403775A GB201403775D0 (en) | 2014-03-04 | 2014-03-04 | Antibodies, uses & methods |
| EP15714253.0A EP3113797B1 (en) | 2014-03-04 | 2015-03-03 | Antibodies, uses&methods |
| PCT/GB2015/050614 WO2015132580A1 (en) | 2014-03-04 | 2015-03-03 | Antibodies, uses & methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20220891T1 true HRP20220891T1 (hr) | 2022-10-14 |
Family
ID=50490750
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20220891TT HRP20220891T1 (hr) | 2014-03-04 | 2015-03-03 | Protutijela, primjene i postupci |
Country Status (21)
| Country | Link |
|---|---|
| US (8) | US10669342B2 (hr) |
| EP (2) | EP3113797B1 (hr) |
| JP (4) | JP6795398B2 (hr) |
| CN (2) | CN106459196B (hr) |
| AU (3) | AU2015225926B2 (hr) |
| CA (1) | CA2941066C (hr) |
| DE (1) | DE112015001085T5 (hr) |
| DK (1) | DK3113797T3 (hr) |
| ES (1) | ES2922734T3 (hr) |
| GB (1) | GB201403775D0 (hr) |
| HR (1) | HRP20220891T1 (hr) |
| HU (1) | HUE059338T2 (hr) |
| IL (2) | IL247582B2 (hr) |
| LT (1) | LT3113797T (hr) |
| NZ (2) | NZ761537A (hr) |
| PL (1) | PL3113797T3 (hr) |
| PT (1) | PT3113797T (hr) |
| RS (1) | RS63408B1 (hr) |
| SG (1) | SG11201607030PA (hr) |
| SI (1) | SI3113797T1 (hr) |
| WO (1) | WO2015132580A1 (hr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| PL3265123T3 (pl) | 2015-03-03 | 2023-03-13 | Kymab Limited | Przeciwciała, zastosowania i sposoby |
| US9512229B2 (en) | 2015-03-03 | 2016-12-06 | Kymab Limited | Synergistic combinations of OX40L antibodies for the treatment of GVHD |
| US9897378B2 (en) | 2015-10-08 | 2018-02-20 | Nyc Designed Inspirations Llc | Cosmetic makeup sponge/blender container |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| TWI760352B (zh) | 2016-08-09 | 2022-04-11 | 英商克馬伯有限公司 | 抗ｉｃｏｓ抗體 |
| CN109843182A (zh) * | 2016-08-18 | 2019-06-04 | 普罗根尼蒂公司 | 使用可摄入装置获取样品的系统 |
| EP3534947A1 (en) | 2016-11-03 | 2019-09-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| GB201709808D0 (en) | 2017-06-20 | 2017-08-02 | Kymab Ltd | Antibodies |
| US11629189B2 (en) | 2017-12-19 | 2023-04-18 | Kymab Limited | Bispecific antibody for ICOS and PD-L1 |
| WO2019173780A2 (en) * | 2018-03-08 | 2019-09-12 | Magenta Therapeutics, Inc. | Anti-cd252 antibodies, conjugates, and methods of use |
| CN112020516A (zh) * | 2018-03-13 | 2020-12-01 | 塔斯克疗法有限公司 | 用于肿瘤特异性细胞清除的抗-cd25 |
| CN111936507B (zh) * | 2018-03-23 | 2022-11-01 | 苏州丁孚靶点生物技术有限公司 | Ox40抗原多肽及其用途 |
| CN111529753A (zh) * | 2020-04-28 | 2020-08-14 | 宁夏医科大学总医院 | 氧化苦参碱-胎盘间充质干细胞水凝胶、制备方法及应用 |
| WO2022060798A1 (en) * | 2020-09-15 | 2022-03-24 | 10X Genomics, Inc. | Methods of releasing an extended capture probe from a substrate and uses of the same |
| CA3226397A1 (en) | 2021-07-22 | 2023-01-26 | Ignacio Moraga GONZALEZ | Therapeutic muteins |
| US20230235069A1 (en) | 2021-08-10 | 2023-07-27 | Kymab Limited | Treatment of atopic dermatitis |
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