DK3043816T3 - Anti-b7-h1-antistoffer til behandling af tumorer - Google Patents

Anti-b7-h1-antistoffer til behandling af tumorer

Info

Publication number
DK3043816T3
DK3043816T3 DK14766962.6T DK14766962T DK3043816T3 DK 3043816 T3 DK3043816 T3 DK 3043816T3 DK 14766962 T DK14766962 T DK 14766962T DK 3043816 T3 DK3043816 T3 DK 3043816T3
Authority
DK
Denmark
Prior art keywords
tumors
antibodies
treatment
Prior art date
Application number
DK14766962.6T
Other languages
English (en)
Inventor
Rajesh Narwal
David Fairman
Paul Robbins
Meina Liang
Amy Schneider
Carlos Chavez
Carina Herl
Min Pak
Hong Lu
Marlon Rebelatto
Keith Steele
Anmarie Boutrin
Li Shi
Shengyan Hong
Brandon Higgs
Lorin Roskos
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Application granted granted Critical
Publication of DK3043816T3 publication Critical patent/DK3043816T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK14766962.6T 2013-09-11 2014-09-11 Anti-b7-h1-antistoffer til behandling af tumorer DK3043816T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361876509P 2013-09-11 2013-09-11
US201461971212P 2014-03-27 2014-03-27
US201461978401P 2014-04-11 2014-04-11
US201462003349P 2014-05-27 2014-05-27
PCT/EP2014/069425 WO2015036499A1 (en) 2013-09-11 2014-09-11 Anti-b7-h1 antibodies for treating tumors

Publications (1)

Publication Number Publication Date
DK3043816T3 true DK3043816T3 (da) 2019-10-14

Family

ID=51570487

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14766962.6T DK3043816T3 (da) 2013-09-11 2014-09-11 Anti-b7-h1-antistoffer til behandling af tumorer

Country Status (19)

Country Link
US (3) US10336823B2 (da)
EP (2) EP3043816B1 (da)
JP (5) JP6550053B2 (da)
KR (5) KR20240056664A (da)
CN (2) CN112546217B (da)
AU (3) AU2014320343B2 (da)
BR (1) BR112016005303A2 (da)
CA (1) CA2923499A1 (da)
DK (1) DK3043816T3 (da)
ES (1) ES2749744T3 (da)
HU (1) HUE046674T2 (da)
IL (5) IL321966A (da)
MX (1) MX370818B (da)
NZ (2) NZ718821A (da)
PL (1) PL3043816T3 (da)
RU (1) RU2701327C2 (da)
SA (1) SA516370713B1 (da)
TW (1) TWI643633B (da)
WO (1) WO2015036499A1 (da)

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Publication number Publication date
AU2024203898A1 (en) 2024-07-04
NZ757060A (en) 2022-07-01
JP7119037B2 (ja) 2022-08-16
AU2020223728A1 (en) 2020-09-17
IL321966A (en) 2025-09-01
KR102661249B1 (ko) 2024-04-25
MX2016002826A (es) 2016-09-13
CA2923499A1 (en) 2015-03-19
EP3656398A1 (en) 2020-05-27
CN105873606B (zh) 2020-12-29
KR20160044030A (ko) 2016-04-22
US10336823B2 (en) 2019-07-02
HUE046674T2 (hu) 2020-03-30
JP2016530323A (ja) 2016-09-29
JP2019163269A (ja) 2019-09-26
KR20220162843A (ko) 2022-12-08
AU2020223728B2 (en) 2024-03-07
US10829557B2 (en) 2020-11-10
IL292193B1 (en) 2024-07-01
IL274462A (en) 2020-06-30
IL313188B1 (en) 2025-08-01
RU2016113341A (ru) 2017-10-16
AU2014320343A1 (en) 2016-04-21
IL292193B2 (en) 2024-11-01
CN112546217B (zh) 2025-04-29
AU2014320343B2 (en) 2020-05-28
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TW201605472A (zh) 2016-02-16
JP2022065100A (ja) 2022-04-26
JP6550053B2 (ja) 2019-07-24
US11827706B2 (en) 2023-11-28
RU2701327C2 (ru) 2019-09-25
ES2749744T3 (es) 2020-03-23
KR20240056664A (ko) 2024-04-30
EP3043816B1 (en) 2019-08-14
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WO2015036499A1 (en) 2015-03-19
US20190338033A1 (en) 2019-11-07
BR112016005303A2 (pt) 2017-09-12
JP2021006537A (ja) 2021-01-21
JP2023166474A (ja) 2023-11-21
EP3043816A1 (en) 2016-07-20
TWI643633B (zh) 2018-12-11
KR102329584B1 (ko) 2021-11-22
CN112546217A (zh) 2021-03-26
IL274462B (en) 2022-05-01
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IL292193A (en) 2022-06-01
US20210171639A1 (en) 2021-06-10
RU2019128452A (ru) 2019-10-24
IL244422A0 (en) 2016-04-21
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CN105873606A (zh) 2016-08-17
IL244422B (en) 2020-05-31
PL3043816T3 (pl) 2020-03-31
KR20210143932A (ko) 2021-11-29
US20160222120A1 (en) 2016-08-04
IL313188A (en) 2024-07-01
RU2016113341A3 (da) 2018-05-30

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