DK1397153T3 - Fremgangsmåde til beskyttelse af allogent ö-celle-transplantat ved anvendelse af oplöselige CTLA4-mutantmolekyler - Google Patents

Fremgangsmåde til beskyttelse af allogent ö-celle-transplantat ved anvendelse af oplöselige CTLA4-mutantmolekyler

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Publication number
DK1397153T3
DK1397153T3 DK02734556T DK02734556T DK1397153T3 DK 1397153 T3 DK1397153 T3 DK 1397153T3 DK 02734556 T DK02734556 T DK 02734556T DK 02734556 T DK02734556 T DK 02734556T DK 1397153 T3 DK1397153 T3 DK 1397153T3
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DK
Denmark
Prior art keywords
soluble ctla4
ctla4 mutant
islet cell
mutant molecules
cell graft
Prior art date
Application number
DK02734556T
Other languages
English (en)
Inventor
Christian P Larsen
Thomas C Pearson
Andrew B Adams
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK1397153T3 publication Critical patent/DK1397153T3/da

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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70521CD28, CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P35/02Antineoplastic agents specific for leukemia
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    • A61P37/02Immunomodulators
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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DK02734556T 2001-05-23 2002-05-23 Fremgangsmåde til beskyttelse af allogent ö-celle-transplantat ved anvendelse af oplöselige CTLA4-mutantmolekyler DK1397153T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29340201P 2001-05-23 2001-05-23
PCT/US2002/016708 WO2002094202A2 (en) 2001-05-23 2002-05-23 Methods for protecting allogeneic islet transplant using soluble ctla4 mutant molecules

Publications (1)

Publication Number Publication Date
DK1397153T3 true DK1397153T3 (da) 2008-05-26

Family

ID=23128937

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02734556T DK1397153T3 (da) 2001-05-23 2002-05-23 Fremgangsmåde til beskyttelse af allogent ö-celle-transplantat ved anvendelse af oplöselige CTLA4-mutantmolekyler

Country Status (17)

Country Link
US (2) US7304033B2 (da)
EP (1) EP1397153B1 (da)
JP (1) JP4837880B2 (da)
AT (1) ATE390931T1 (da)
AU (1) AU2002305716B2 (da)
CA (1) CA2447921C (da)
CY (1) CY1108127T1 (da)
CZ (1) CZ305380B6 (da)
DE (1) DE60225914T2 (da)
DK (1) DK1397153T3 (da)
ES (1) ES2302811T3 (da)
HU (1) HU229680B1 (da)
MX (1) MXPA03010568A (da)
NO (1) NO332465B1 (da)
PL (1) PL204899B1 (da)
PT (1) PT1397153E (da)
WO (1) WO2002094202A2 (da)

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DE60225914T2 (de) 2009-07-23
CA2447921C (en) 2011-08-09
NO20035176L (no) 2004-01-05
CY1108127T1 (el) 2014-02-12
AU2002305716B8 (en) 2002-12-03
JP4837880B2 (ja) 2011-12-14
WO2002094202A3 (en) 2003-06-26
DE60225914D1 (de) 2008-05-15
PL204899B1 (pl) 2010-02-26
US20080160022A1 (en) 2008-07-03
ES2302811T3 (es) 2008-08-01
EP1397153A4 (en) 2006-01-04
CA2447921A1 (en) 2002-11-28
NO20035176D0 (no) 2003-11-21
PT1397153E (pt) 2008-06-12
HUP0401590A3 (en) 2012-09-28
AU2002305716B2 (en) 2007-10-25
CZ305380B6 (cs) 2015-08-26
HU229680B1 (hu) 2014-04-28
EP1397153B1 (en) 2008-04-02
HUP0401590A2 (hu) 2004-11-29
CZ20033188A3 (cs) 2005-04-13
PL364578A1 (en) 2004-12-13
NO332465B1 (no) 2012-09-24
ATE390931T1 (de) 2008-04-15
JP2004535402A (ja) 2004-11-25
US7829534B2 (en) 2010-11-09
US20030022836A1 (en) 2003-01-30
WO2002094202B1 (en) 2003-07-31
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WO2002094202A2 (en) 2002-11-28

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