NO984740L - Isatinderivater som acetylcholinesteraseinhibitorer og analgetiske midler - Google Patents
Isatinderivater som acetylcholinesteraseinhibitorer og analgetiske midlerInfo
- Publication number
- NO984740L NO984740L NO984740A NO984740A NO984740L NO 984740 L NO984740 L NO 984740L NO 984740 A NO984740 A NO 984740A NO 984740 A NO984740 A NO 984740A NO 984740 L NO984740 L NO 984740L
- Authority
- NO
- Norway
- Prior art keywords
- analgesics
- compounds
- acetylcholinesterase inhibitors
- isatin derivatives
- isatin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Foreliggende søknad angår forbindelser av formel (I) (D hvori R, X og Y er som definert, hvilke forbindelser er anvendbare for behand- ling av hukommelsesdysfunksjon som er karakterisert ved redusert cholinerg funksjon, og for analgesi, farmasøyt- iske preparater inneholdende forbindel- sene og metoder for fremstilling og anvendelse av forbindelsene.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63187096A | 1996-04-12 | 1996-04-12 | |
PCT/US1997/003598 WO1997038993A1 (en) | 1996-04-12 | 1997-03-07 | Isatin derivatives as acetylcholinesterase inhibitors and analgesics |
Publications (2)
Publication Number | Publication Date |
---|---|
NO984740D0 NO984740D0 (no) | 1998-10-09 |
NO984740L true NO984740L (no) | 1998-10-09 |
Family
ID=24533114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO984740A NO984740L (no) | 1996-04-12 | 1998-10-09 | Isatinderivater som acetylcholinesteraseinhibitorer og analgetiske midler |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0892796B1 (no) |
JP (1) | JP4109718B2 (no) |
KR (1) | KR20000005379A (no) |
CN (1) | CN1215399A (no) |
AR (1) | AR006606A1 (no) |
AT (1) | ATE207483T1 (no) |
BR (1) | BR9708655A (no) |
CA (1) | CA2252039C (no) |
DE (1) | DE69707659T2 (no) |
DK (1) | DK0892796T3 (no) |
ES (1) | ES2165586T3 (no) |
GR (1) | GR3037006T3 (no) |
HU (1) | HUP9903473A3 (no) |
IL (1) | IL126308A0 (no) |
NO (1) | NO984740L (no) |
PT (1) | PT892796E (no) |
TW (1) | TW426678B (no) |
WO (1) | WO1997038993A1 (no) |
ZA (1) | ZA972990B (no) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6218383B1 (en) | 1998-08-07 | 2001-04-17 | Targacept, Inc. | Pharmaceutical compositions for the prevention and treatment of central nervous system disorders |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
MX2009009234A (es) | 2007-03-01 | 2009-12-01 | Probiodrug Ag | Uso nuevo de inhibidores de ciclasa de glutaminilo. |
EP2865670B1 (en) | 2007-04-18 | 2017-01-11 | Probiodrug AG | Thiourea derivatives as glutaminyl cyclase inhibitors |
ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
CN102905532A (zh) | 2010-02-09 | 2013-01-30 | 约翰斯.霍普金斯大学 | 用于改善认知功能的方法和组合物 |
IN2012DN06631A (no) | 2010-02-16 | 2015-10-23 | Pfizer | |
ES2586231T3 (es) | 2010-03-03 | 2016-10-13 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
AU2011226074B2 (en) | 2010-03-10 | 2015-01-22 | Vivoryon Therapeutics N.V. | Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5) |
EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
BR112015013675B1 (pt) | 2012-12-13 | 2022-04-26 | H. Lundbeck A/S | Composição compreendendo vortioxetina e donepezil e usos dos mesmos |
WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
WO2014144801A1 (en) | 2013-03-15 | 2014-09-18 | Agenebio Inc. | Methods and compositions for improving cognitive function |
US10537552B2 (en) | 2015-05-05 | 2020-01-21 | Carafe Drug Innovation, Llc | Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers |
EA034167B8 (ru) | 2015-05-22 | 2021-04-27 | Эйджинбайо, Инк. | Фармацевтические композиции леветирацетама пролонгированного высвобождения |
DK3461819T3 (da) | 2017-09-29 | 2020-08-10 | Probiodrug Ag | Inhibitorer af glutaminylcyklase |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5296488A (en) * | 1989-08-02 | 1994-03-22 | Hoechst-Roussel Pharmaceuticals Inc. | Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory |
US4994472A (en) * | 1989-08-02 | 1991-02-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 1-(pyridinylamino)-2-pyrrolidinones as pain relievers |
US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
-
1997
- 1997-03-07 WO PCT/US1997/003598 patent/WO1997038993A1/en active IP Right Grant
- 1997-03-07 JP JP53708497A patent/JP4109718B2/ja not_active Expired - Fee Related
- 1997-03-07 HU HU9903473A patent/HUP9903473A3/hu unknown
- 1997-03-07 IL IL12630897A patent/IL126308A0/xx unknown
- 1997-03-07 PT PT97908942T patent/PT892796E/pt unknown
- 1997-03-07 CN CN97193728A patent/CN1215399A/zh active Pending
- 1997-03-07 EP EP97908942A patent/EP0892796B1/en not_active Expired - Lifetime
- 1997-03-07 BR BR9708655A patent/BR9708655A/pt not_active Application Discontinuation
- 1997-03-07 DE DE69707659T patent/DE69707659T2/de not_active Expired - Fee Related
- 1997-03-07 AT AT97908942T patent/ATE207483T1/de not_active IP Right Cessation
- 1997-03-07 DK DK97908942T patent/DK0892796T3/da active
- 1997-03-07 CA CA002252039A patent/CA2252039C/en not_active Expired - Fee Related
- 1997-03-07 ES ES97908942T patent/ES2165586T3/es not_active Expired - Lifetime
- 1997-04-07 TW TW086104363A patent/TW426678B/zh active
- 1997-04-08 ZA ZA9702990A patent/ZA972990B/xx unknown
- 1997-04-11 AR ARP970101447A patent/AR006606A1/es unknown
-
1998
- 1998-10-09 NO NO984740A patent/NO984740L/no unknown
- 1998-10-12 KR KR1019980708105A patent/KR20000005379A/ko active IP Right Grant
-
2001
- 2001-10-25 GR GR20010401584T patent/GR3037006T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2252039C (en) | 2002-12-24 |
EP0892796A1 (en) | 1999-01-27 |
ES2165586T3 (es) | 2002-03-16 |
HUP9903473A3 (en) | 2000-09-28 |
DK0892796T3 (da) | 2001-11-19 |
TW426678B (en) | 2001-03-21 |
JP2001508400A (ja) | 2001-06-26 |
EP0892796B1 (en) | 2001-10-24 |
DE69707659T2 (de) | 2002-05-08 |
KR20000005379A (en) | 2000-01-25 |
AU716997B2 (en) | 2000-03-16 |
JP4109718B2 (ja) | 2008-07-02 |
IL126308A0 (en) | 1999-05-09 |
CA2252039A1 (en) | 1997-10-23 |
CN1215399A (zh) | 1999-04-28 |
AU2072597A (en) | 1997-11-07 |
AR006606A1 (es) | 1999-09-08 |
BR9708655A (pt) | 1999-08-03 |
NO984740D0 (no) | 1998-10-09 |
ATE207483T1 (de) | 2001-11-15 |
ZA972990B (en) | 1997-11-03 |
HUP9903473A2 (hu) | 2000-05-28 |
PT892796E (pt) | 2002-03-28 |
WO1997038993A1 (en) | 1997-10-23 |
DE69707659D1 (de) | 2001-11-29 |
GR3037006T3 (en) | 2002-01-31 |
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