NO990896L - Bidentate metalloproteaseinhibitorer - Google Patents

Bidentate metalloproteaseinhibitorer

Info

Publication number
NO990896L
NO990896L NO990896A NO990896A NO990896L NO 990896 L NO990896 L NO 990896L NO 990896 A NO990896 A NO 990896A NO 990896 A NO990896 A NO 990896A NO 990896 L NO990896 L NO 990896L
Authority
NO
Norway
Prior art keywords
bidentate
compounds
metalloprotease inhibitors
pharmaceutical compositions
inhibitors
Prior art date
Application number
NO990896A
Other languages
English (en)
Other versions
NO990896D0 (no
Inventor
Neil Gregory Almstead
Biswanath De
Rimmi Sandler Bradley
Garry Steven Garrett
Ii John Emory Marlin
John Mcmillan Mciver
Zhe Wang
Yetunde Olabisi Taiwo
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO990896D0 publication Critical patent/NO990896D0/no
Publication of NO990896L publication Critical patent/NO990896L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Confectionery (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Oppfinnelsen fremskaffer forbindelser som er nyttige som inhibitorer av metalloproteaser, og som er effektive for å behandle tilstander karakterisert ved overskuddsaktivitet av disse enzymene. Spesielt vedrører den foreliggende oppfinnelse en forbindelse som har en struktur i henhold til formel (I) SCfe-A- Som beskrevet.i kravene, eller en optisk iso- mer, diastereomer eller en antiomer derav, eller et farmasøytisk akseptabelt salt, eller biohydrolyserbare alkoksyamid, ester, acyl- oksyamid eller imid derav. Også brakt for dagen er forbindelser, farmasøytiske sammen- setninger og fremgangsmåter for å behandle sykdommer karakterisert ved metalloprotease- aktivitet ved å bruke disse forbindelsene eller de farmasøytiske sammensetningene inne- holdende disse.
NO990896A 1996-08-28 1999-02-25 Bidentate metalloproteaseinhibitorer NO990896L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2474696P 1996-08-28 1996-08-28
PCT/US1997/014554 WO1998008814A1 (en) 1996-08-28 1997-08-22 Bidentate metalloprotease inhibitors

Publications (2)

Publication Number Publication Date
NO990896D0 NO990896D0 (no) 1999-02-25
NO990896L true NO990896L (no) 1999-04-20

Family

ID=21822181

Family Applications (1)

Application Number Title Priority Date Filing Date
NO990896A NO990896L (no) 1996-08-28 1999-02-25 Bidentate metalloproteaseinhibitorer

Country Status (20)

Country Link
US (1) US6121272A (no)
EP (1) EP0923547A1 (no)
JP (1) JP2000516954A (no)
KR (1) KR20000035921A (no)
CN (1) CN1228767A (no)
AU (1) AU4074097A (no)
BR (1) BR9712792A (no)
CA (1) CA2263914A1 (no)
CO (1) CO5420196A1 (no)
CZ (1) CZ62499A3 (no)
HU (1) HUP0000616A2 (no)
ID (1) ID18417A (no)
IL (1) IL128665A0 (no)
NO (1) NO990896L (no)
PE (1) PE109298A1 (no)
PL (1) PL331803A1 (no)
SK (1) SK24899A3 (no)
TR (1) TR199900401T2 (no)
WO (1) WO1998008814A1 (no)
ZA (1) ZA977697B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL134273A0 (en) 1997-07-31 2001-04-30 Procter & Gamble Acyclic metalloprotease inhibitors
US6410580B1 (en) 1998-02-04 2002-06-25 Novartis Ag Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
RU2208609C2 (ru) 1998-02-04 2003-07-20 Новартис Аг Сульфониламинопроизводные, которые ингибируют разлагающие матрикс металлопротеиназы
US6846478B1 (en) 1998-02-27 2005-01-25 The Procter & Gamble Company Promoting whole body health
JP2002516904A (ja) 1998-06-03 2002-06-11 ジーピーアイ ニル ホールディングス インコーポレイテッド Ｎ−複素環式カルボン酸またはカルボン酸等配電子体のｎ−結合スルホンアミド
CA2344412A1 (en) 1998-09-21 2000-03-30 Takeda Chemical Industries, Ltd. Thiol compound, their production and use
US6566381B1 (en) 1999-03-03 2003-05-20 The Procter & Gamble Company Hetero-substituted metalloprotease inhibitors
WO2000051975A1 (en) 1999-03-03 2000-09-08 The Procter & Gamble Company Alkenyl- and alkynyl-containing metalloprotease inhibitors
WO2001010837A1 (en) * 1999-08-05 2001-02-15 The Procter & Gamble Company Multivalent sulfonamides
WO2001010838A1 (en) * 1999-08-05 2001-02-15 The Procter & Gamble Company Multivalent compounds
US8283135B2 (en) 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
MXPA03000043A (es) 2000-06-30 2003-10-15 Procter & Gamble Promocion de la salud en todo el cuerpo.
JP3983662B2 (ja) 2000-07-19 2007-09-26 エフ．ホフマン−ラ ロシュ アーゲー ピリミジン誘導体
JP4068452B2 (ja) 2000-07-19 2008-03-26 エフ．ホフマン−ラ ロシュ アーゲー エンドセリン変換酵素阻害剤としてのピロリジン誘導体
KR100613196B1 (ko) * 2000-07-19 2006-08-18 에프. 호프만-라 로슈 아게 메탈로프로테아제 억제제로서의 피롤리딘 유도체
FR2819252A1 (fr) * 2001-01-11 2002-07-12 Servier Lab Nouveaux derives d'acide hydroxamique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2005500270A (ja) * 2001-05-29 2005-01-06 ギルフォード ファーマシュウティカルズ インコーポレイテッド 手術の結果として発生した神経損傷を治療するための方法
DE60329326D1 (de) * 2002-12-19 2009-10-29 Vertex Pharma Tace inhibitoren
US7897776B2 (en) 2007-04-23 2011-03-01 Salutria Pharmaceuticals Llc Sulfonamide containing compounds for treatment of inflammatory disorders
CN106905183B (zh) * 2017-02-24 2018-07-31 三峡大学 一类含氨基的ɑ-酰氧基羰基酰胺类衍生物，制备方法及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3501489A (en) * 1966-01-21 1970-03-17 American Home Prod 1-phenylsulfonyl-2-(2-thiazolin-2-yl-oxy and thiol) pyrrolidines
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
IL74140A (en) * 1984-04-10 1988-05-31 Robins Co Inc A H Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them
US4595700A (en) * 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
IT1215590B (it) * 1987-06-29 1990-02-14 Roussel Maestretti Spa Derivati della 1-benzene solfonil 2-oco 5-alchiltio pirrolidina, un loro procedimentodi preparazione e il loro impiegocome stostanze medicinali.
GB8814813D0 (en) * 1988-06-22 1988-07-27 Beecham Group Plc Novel compounds
DE4011172A1 (de) * 1990-04-06 1991-10-10 Degussa Verbindungen zur bekaempfung von pflanzenkrankheiten
ES2069137T3 (es) * 1990-07-30 1995-05-01 Takeda Chemical Industries Ltd Derivados de imidazopiridina y su uso.
JPH05125029A (ja) * 1991-11-06 1993-05-21 Yamanouchi Pharmaceut Co Ltd 新規なアミド化合物又はその塩
US6090785A (en) * 1992-10-15 2000-07-18 Merck & Co., Inc. Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5455262A (en) * 1993-10-06 1995-10-03 Florida State University Mercaptosulfide metalloproteinase inhibitors
US5470834A (en) * 1993-10-06 1995-11-28 Florida State University Sulfoximine and suldodiimine matrix metalloproteinase inhibitors
US5962529A (en) * 1994-06-22 1999-10-05 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
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EP1095936B1 (en) * 1995-12-08 2004-11-24 Agouron Pharmaceuticals, Inc. Intermediates useful for the preparation of metallproteinase inhibitors

Also Published As

Publication number Publication date
SK24899A3 (en) 2000-04-10
US6121272A (en) 2000-09-19
WO1998008814A1 (en) 1998-03-05
HUP0000616A2 (en) 2000-07-28
PE109298A1 (es) 1999-01-31
CZ62499A3 (cs) 1999-07-14
CN1228767A (zh) 1999-09-15
TR199900401T2 (xx) 1999-05-21
ZA977697B (en) 1998-02-23
CA2263914A1 (en) 1998-03-05
ID18417A (id) 1998-04-09
IL128665A0 (en) 2000-01-31
KR20000035921A (ko) 2000-06-26
NO990896D0 (no) 1999-02-25
BR9712792A (pt) 1999-12-14
AU4074097A (en) 1998-03-19
JP2000516954A (ja) 2000-12-19
CO5420196A1 (es) 2004-07-30
EP0923547A1 (en) 1999-06-23
PL331803A1 (en) 1999-08-02

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application