PE109298A1 - Compuestos heterociclicos inhibidores de metaloproteasas - Google Patents
Compuestos heterociclicos inhibidores de metaloproteasasInfo
- Publication number
- PE109298A1 PE109298A1 PE1997000772A PE00077297A PE109298A1 PE 109298 A1 PE109298 A1 PE 109298A1 PE 1997000772 A PE1997000772 A PE 1997000772A PE 00077297 A PE00077297 A PE 00077297A PE 109298 A1 PE109298 A1 PE 109298A1
- Authority
- PE
- Peru
- Prior art keywords
- hetero
- aryl
- compounds
- alkyl
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: Ar ES ALQUILO, ARILO, CARBOCICLO, HETEROCICLO O HETEROARILO; "W" ES O o S; "Y" ES H, OH, OXO, ENTRE OTROS; "Z" ES (CH2)m(CR1R2)oSR3, -(SH)CHCH2COOCH3 o -(SH)CHCH2SR3; R1 ES H, ALQUILO, CH2SR3, CH2C(W)R4; R2 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS; R3 ES H, ALQUILO, ARILO, ENTRE OTROS, DE PREFERENCIA ES HETEROARILO; R4 ES ALCOXI, OH, NR5, ALQUILTIO o TIO; R5 ES HETEROCICLILALQUILO, ALQUILO, ARILO, ENTRE OTROS; n ES 1; 2 o 3, DE PREFERENCIA n ES 2; m Y o SON 0; 1 o 2. LOS COMPUESTOS DE FORMULA (I) ACTUAN COMO INHIBIDORES DE LAS ENZIMAS METALOPROTEASAS DE LA MATRIZ, SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDEA, OSTEOARTRITIS, METASTASIS DE LAS CELULAS DEL TUMOR, DESORDENES CARDIOVASCULARES, DESORDENES OCULARES Y LESIONES ULCERATIVAS, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2474696P | 1996-08-28 | 1996-08-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE109298A1 true PE109298A1 (es) | 1999-01-31 |
Family
ID=21822181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1997000772A PE109298A1 (es) | 1996-08-28 | 1997-08-28 | Compuestos heterociclicos inhibidores de metaloproteasas |
Country Status (20)
Country | Link |
---|---|
US (1) | US6121272A (es) |
EP (1) | EP0923547A1 (es) |
JP (1) | JP2000516954A (es) |
KR (1) | KR20000035921A (es) |
CN (1) | CN1228767A (es) |
AU (1) | AU4074097A (es) |
BR (1) | BR9712792A (es) |
CA (1) | CA2263914A1 (es) |
CO (1) | CO5420196A1 (es) |
CZ (1) | CZ62499A3 (es) |
HU (1) | HUP0000616A2 (es) |
ID (1) | ID18417A (es) |
IL (1) | IL128665A0 (es) |
NO (1) | NO990896L (es) |
PE (1) | PE109298A1 (es) |
PL (1) | PL331803A1 (es) |
SK (1) | SK24899A3 (es) |
TR (1) | TR199900401T2 (es) |
WO (1) | WO1998008814A1 (es) |
ZA (1) | ZA977697B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0004595A3 (en) | 1997-07-31 | 2001-12-28 | Procter & Gamble | Acyclic metalloprotease inhibitors |
US6410580B1 (en) | 1998-02-04 | 2002-06-25 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
CN1195735C (zh) | 1998-02-04 | 2005-04-06 | 诺瓦提斯公司 | 抑制使基质退化的金属蛋白酶的磺酰氨基衍生物 |
US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
AU1708099A (en) | 1998-06-03 | 1999-12-20 | Amgen, Inc. | N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres |
EP1132379A4 (en) | 1998-09-21 | 2005-02-16 | Takeda Pharmaceutical | THIOL DERIVATIVES, METHOD FOR THEIR PREPARATION AND THEIR USE |
NZ513830A (en) | 1999-03-03 | 2001-09-28 | Procter & Gamble | Dihetero-substituted metalloprotease inhibitors |
PL350340A1 (en) | 1999-03-03 | 2002-12-02 | Procter & Gamble | Alkenyl- and alkynyl-containing metalloprotease inhibitors |
WO2001010837A1 (en) * | 1999-08-05 | 2001-02-15 | The Procter & Gamble Company | Multivalent sulfonamides |
WO2001010838A1 (en) * | 1999-08-05 | 2001-02-15 | The Procter & Gamble Company | Multivalent compounds |
MXPA03000043A (es) | 2000-06-30 | 2003-10-15 | Procter & Gamble | Promocion de la salud en todo el cuerpo. |
US8283135B2 (en) | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
EP1303485A1 (en) | 2000-07-19 | 2003-04-23 | F. Hoffmann-La Roche Ag | Pyrrolidine derivatives as inhibitors of endothelin-converting enzyme |
CA2415681C (en) | 2000-07-19 | 2008-05-20 | F. Hoffmann-La Roche Ag | Pyrrolidine derivatives |
AU2001278479B2 (en) | 2000-07-19 | 2007-06-21 | F. Hoffmann-La Roche Ag | Pyrrolidine derivatives as metalloprotease inhibitors |
FR2819252A1 (fr) * | 2001-01-11 | 2002-07-12 | Servier Lab | Nouveaux derives d'acide hydroxamique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
CA2449019A1 (en) * | 2001-05-29 | 2002-12-05 | Guilford Pharmaceuticals Inc. | Method for treating nerve injury caused by surgery |
WO2004056766A1 (en) * | 2002-12-19 | 2004-07-08 | Vertex Pharmaceuticals Incorporated | Inhibitors of tace |
WO2008130718A1 (en) | 2007-04-23 | 2008-10-30 | Atherogenics, Inc. | Sulfonamide containing compounds for treatment of inflammatory disorders |
CN106905183B (zh) * | 2017-02-24 | 2018-07-31 | 三峡大学 | 一类含氨基的ɑ-酰氧基羰基酰胺类衍生物,制备方法及其应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3501489A (en) * | 1966-01-21 | 1970-03-17 | American Home Prod | 1-phenylsulfonyl-2-(2-thiazolin-2-yl-oxy and thiol) pyrrolidines |
US4695575A (en) * | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
IL74140A (en) * | 1984-04-10 | 1988-05-31 | Robins Co Inc A H | Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them |
US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
GB8515934D0 (en) * | 1985-06-24 | 1985-07-24 | Janssen Pharmaceutica Nv | (4-piperidinomethyl and-hetero)purines |
IT1215590B (it) * | 1987-06-29 | 1990-02-14 | Roussel Maestretti Spa | Derivati della 1-benzene solfonil 2-oco 5-alchiltio pirrolidina, un loro procedimentodi preparazione e il loro impiegocome stostanze medicinali. |
GB8814813D0 (en) * | 1988-06-22 | 1988-07-27 | Beecham Group Plc | Novel compounds |
DE4011172A1 (de) * | 1990-04-06 | 1991-10-10 | Degussa | Verbindungen zur bekaempfung von pflanzenkrankheiten |
ATE119774T1 (de) * | 1990-07-30 | 1995-04-15 | Takeda Chemical Industries Ltd | Imidazopyridinderivate und ihre verwendung. |
JPH05125029A (ja) * | 1991-11-06 | 1993-05-21 | Yamanouchi Pharmaceut Co Ltd | 新規なアミド化合物又はその塩 |
US6090785A (en) * | 1992-10-15 | 2000-07-18 | Merck & Co., Inc. | Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents |
US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5455262A (en) * | 1993-10-06 | 1995-10-03 | Florida State University | Mercaptosulfide metalloproteinase inhibitors |
US5470834A (en) * | 1993-10-06 | 1995-11-28 | Florida State University | Sulfoximine and suldodiimine matrix metalloproteinase inhibitors |
ATE191468T1 (de) * | 1994-06-22 | 2000-04-15 | British Biotech Pharm | Metalloproteinase inhibitoren |
CN1064682C (zh) * | 1995-07-31 | 2001-04-18 | 盐野义制药株式会社 | 具有磷脂酶a2抑制活性的吡咯烷衍生物 |
IL138027A (en) * | 1995-12-08 | 2004-08-31 | Agouron Pharma | Intermediates for the preparation and preparation of metalloproteinase inhibitors |
-
1997
- 1997-07-09 BR BR9712792-2A patent/BR9712792A/pt unknown
- 1997-08-22 PL PL97331803A patent/PL331803A1/xx unknown
- 1997-08-22 IL IL12866597A patent/IL128665A0/xx unknown
- 1997-08-22 HU HU0000616A patent/HUP0000616A2/hu unknown
- 1997-08-22 EP EP97938411A patent/EP0923547A1/en not_active Withdrawn
- 1997-08-22 CN CN97197547A patent/CN1228767A/zh active Pending
- 1997-08-22 CA CA002263914A patent/CA2263914A1/en not_active Abandoned
- 1997-08-22 AU AU40740/97A patent/AU4074097A/en not_active Withdrawn
- 1997-08-22 WO PCT/US1997/014554 patent/WO1998008814A1/en not_active Application Discontinuation
- 1997-08-22 KR KR1019997001657A patent/KR20000035921A/ko not_active Application Discontinuation
- 1997-08-22 JP JP10511714A patent/JP2000516954A/ja active Pending
- 1997-08-22 TR TR1999/00401T patent/TR199900401T2/xx unknown
- 1997-08-22 SK SK248-99A patent/SK24899A3/sk unknown
- 1997-08-22 CZ CZ99624A patent/CZ62499A3/cs unknown
- 1997-08-26 US US08/918,318 patent/US6121272A/en not_active Expired - Fee Related
- 1997-08-27 CO CO97049500A patent/CO5420196A1/es not_active Application Discontinuation
- 1997-08-27 ZA ZA9407697A patent/ZA977697B/xx unknown
- 1997-08-28 PE PE1997000772A patent/PE109298A1/es not_active Application Discontinuation
- 1997-08-28 ID IDP972998A patent/ID18417A/id unknown
-
1999
- 1999-02-25 NO NO990896A patent/NO990896L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO990896L (no) | 1999-04-20 |
BR9712792A (pt) | 1999-12-14 |
CA2263914A1 (en) | 1998-03-05 |
PL331803A1 (en) | 1999-08-02 |
JP2000516954A (ja) | 2000-12-19 |
SK24899A3 (en) | 2000-04-10 |
NO990896D0 (no) | 1999-02-25 |
ID18417A (id) | 1998-04-09 |
HUP0000616A2 (en) | 2000-07-28 |
WO1998008814A1 (en) | 1998-03-05 |
EP0923547A1 (en) | 1999-06-23 |
US6121272A (en) | 2000-09-19 |
ZA977697B (en) | 1998-02-23 |
IL128665A0 (en) | 2000-01-31 |
AU4074097A (en) | 1998-03-19 |
CN1228767A (zh) | 1999-09-15 |
KR20000035921A (ko) | 2000-06-26 |
CZ62499A3 (cs) | 1999-07-14 |
TR199900401T2 (xx) | 1999-05-21 |
CO5420196A1 (es) | 2004-07-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE109298A1 (es) | Compuestos heterociclicos inhibidores de metaloproteasas | |
PE108998A1 (es) | Compuestos heterociclicos inhibidores de metaloproteasas | |
PE107798A1 (es) | Inhibidores espirociclicos de la metaloproteasa | |
FI970417A (fi) | Aryylitioyhdisteet bakteerien ja virusten vastaisina aineina | |
EA199800768A1 (ru) | Новые производные эритромицина, способ их получения и их применение в качестве медикаментов | |
PE2599A1 (es) | Compuesto heterociclo inhibidor de metaloproteasa | |
MY110226A (en) | Therapeutic heterocyclic compounds. | |
DE69021679D1 (de) | Verwendung von Bis(3,4-Dialkylbenzyliden)sorbitolacetale und diese enthaltende Zusammensetzungen. | |
ES2111654T3 (es) | Derivados de piperazina como antagonistas de 5-ht1a. | |
PE34297A1 (es) | Ligandos especificos del neuropeptido y1 | |
DE68908737D1 (de) | Imidazol-Verbindungen und diese enthaltende Textilbehandlungs-Zusammenstellungen. | |
DE69031913D1 (de) | Antivirale mittel | |
ATE324113T1 (de) | Verwendung von 2,6-dialkyl-4-silyl-phenol derivaten zur behandlung von xanthom | |
GEP19991779B (en) | Use of Aminoadamantane Compounds as Immunoregulators | |
NZ331618A (en) | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents | |
DE3784642D1 (de) | Verwendung von aromatischen carbonsaeureamiden. | |
DE69921180D1 (de) | Künstliche matrix-anheftungsregion zur erhöhung der expression von in pflanzen eingeführten genen | |
DE69810800T2 (de) | Azetidinonderivate zur behandlung von hcmv entzündungen | |
ATE177103T1 (de) | Bicycloaliphatische 2-methylen-1,3-dioxepane | |
GR3023757T3 (en) | Cyclic benzylamino, benzylamido and benzylimido derivatives as antipsychotic agents. | |
ATE39921T1 (de) | Verfahren zur herstellung von azetidinonen mit chiralitaetszentrum. | |
UY24009A1 (es) | Compuestos ariltio útiles como agentes antivirales y antibacteriales | |
BR9707321A (pt) | Dihidrobenzofurano e compostor correlatos úteis como agentes antinflamatórios | |
PE20001607A1 (es) | 4-AMINO-4,5-DIHIDRO-BENZO[b][1,4]DIOXOCIN-3-ONA COMO INHIBIDORES DE PROTEASAS | |
ES439856A1 (es) | Un procedimiento para la preparacion de nuevos eteres basi- cos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FX | Voluntary withdrawal |