BR9707321A - Dihidrobenzofurano e compostor correlatos úteis como agentes antinflamatórios - Google Patents

Dihidrobenzofurano e compostor correlatos úteis como agentes antinflamatórios

Info

Publication number
BR9707321A
BR9707321A BR9707321A BR9707321A BR9707321A BR 9707321 A BR9707321 A BR 9707321A BR 9707321 A BR9707321 A BR 9707321A BR 9707321 A BR9707321 A BR 9707321A BR 9707321 A BR9707321 A BR 9707321A
Authority
BR
Brazil
Prior art keywords
branched
straight
composter
dihydrobenzofuran
useful
Prior art date
Application number
BR9707321A
Other languages
English (en)
Inventor
John Michael Janusz
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of BR9707321A publication Critical patent/BR9707321A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR9707321A 1996-02-01 1997-01-30 Dihidrobenzofurano e compostor correlatos úteis como agentes antinflamatórios BR9707321A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/595,122 US5684031A (en) 1996-02-01 1996-02-01 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
PCT/US1997/001311 WO1997028145A1 (en) 1996-02-01 1997-01-30 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
BR9707321A true BR9707321A (pt) 1999-04-13

Family

ID=24381828

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9707321A BR9707321A (pt) 1996-02-01 1997-01-30 Dihidrobenzofurano e compostor correlatos úteis como agentes antinflamatórios

Country Status (15)

Country Link
US (1) US5684031A (pt)
EP (1) EP0904270B1 (pt)
JP (1) JP3095423B2 (pt)
KR (1) KR100322400B1 (pt)
CN (1) CN1109680C (pt)
AT (1) ATE250594T1 (pt)
AU (1) AU730263B2 (pt)
BR (1) BR9707321A (pt)
CA (1) CA2244402C (pt)
DE (1) DE69725133T2 (pt)
DK (1) DK0904270T3 (pt)
ES (1) ES2208872T3 (pt)
MX (1) MX9806249A (pt)
NO (1) NO983527L (pt)
WO (1) WO1997028145A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866579A (en) * 1997-04-11 1999-02-02 Synaptic Pharmaceutical Corporation Imidazole and imidazoline derivatives and uses thereof
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

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US3551456A (en) * 1968-04-18 1970-12-29 Universal Oil Prod Co Acetyl derivatives of substituted chromans and coumarans
JPS6031829B2 (ja) * 1975-06-26 1985-07-24 ウェルファイド株式会社 アミノアルコ−ル誘導体の製造法
FR2332010A1 (fr) * 1975-11-18 1977-06-17 Continental Pharma Amino-alcool heterocyclique, son sel et son procede de preparation
FR2370472A2 (fr) * 1976-11-10 1978-06-09 Continental Pharma Amino-alcool heterocyclique, son sel et son procede de preparation
CH615031A5 (pt) * 1976-04-30 1979-12-28 Gretag Ag
JPS6019305B2 (ja) * 1976-07-02 1985-05-15 ウェルファイド株式会社 ジヒドロベンゾフラン誘導体
JPS603305B2 (ja) * 1976-12-27 1985-01-26 エーザイ株式会社 ２，３―ジハイドロベンゾフラン誘導体
US4398028A (en) * 1977-01-14 1983-08-09 Sandoz Ltd. Bicyclic heterocyclic amino derivatives
US4130666A (en) * 1977-05-16 1978-12-19 Riker Laboratories, Inc. Anti-inflammatory method
IT1093805B (it) * 1978-01-31 1985-07-26 Erba Carlo Spa Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
EP0026593A1 (en) * 1979-09-15 1981-04-08 Pfizer Limited Bicyclic keto- and amino- acids, esters and amides and pharmaceutical compositions thereof
US4470440A (en) * 1982-09-30 1984-09-11 Thor Harry A Impact producing tool
GR81257B (pt) * 1982-12-04 1984-12-11 Lilly Industries Ltd
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FI842738A (fi) * 1983-07-14 1985-01-15 Syntex Inc Aroylbenzofuran- och benzotiofenaettik- och propionsyror.
US4613611A (en) * 1983-10-14 1986-09-23 American Cyanamid Company Method of treating diabetes mellitus using arylglyoxals
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US4708966A (en) * 1986-06-27 1987-11-24 The Procter & Gamble Company Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation
EP0273647B1 (en) * 1986-12-27 1992-03-11 Takeda Chemical Industries, Ltd. Coumaran derivatives, their production and use
FR2613364B1 (fr) * 1987-04-01 1989-06-09 Adir Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2613365B1 (fr) * 1987-04-01 1989-07-28 Adir Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
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IL88674A0 (en) * 1987-12-18 1989-07-31 Norwich Eaton Pharma Preparation of certain substituted aromatic compounds
JPH07121933B2 (ja) * 1988-03-28 1995-12-25 キッセイ薬品工業株式会社 ジヒドロベンゾフラノン誘導体
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
FR2645537B1 (fr) * 1989-04-05 1994-03-04 Fabre Medicament Pierre Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique
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US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents

Also Published As

Publication number Publication date
JPH11506120A (ja) 1999-06-02
JP3095423B2 (ja) 2000-10-03
WO1997028145A1 (en) 1997-08-07
NO983527L (no) 1998-09-28
KR19990082220A (ko) 1999-11-25
EP0904270A1 (en) 1999-03-31
US5684031A (en) 1997-11-04
AU1843097A (en) 1997-08-22
CN1109680C (zh) 2003-05-28
DK0904270T3 (da) 2003-12-01
ATE250594T1 (de) 2003-10-15
CA2244402C (en) 2003-10-07
DE69725133D1 (de) 2003-10-30
EP0904270B1 (en) 2003-09-24
ES2208872T3 (es) 2004-06-16
KR100322400B1 (ko) 2002-05-09
MX9806249A (es) 1998-11-30
CA2244402A1 (en) 1997-08-07
NO983527D0 (no) 1998-07-31
AU730263B2 (en) 2001-03-01
CN1210532A (zh) 1999-03-10
DE69725133T2 (de) 2004-07-15

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Legal Events

Date Code Title Description
PC Transfer

Free format text: VANDERBILT UNIVERSITY (US)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1892 DE 10/04/2007.