MX9806250A - Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. - Google Patents

Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.

Info

Publication number
MX9806250A
MX9806250A MX9806250A MX9806250A MX9806250A MX 9806250 A MX9806250 A MX 9806250A MX 9806250 A MX9806250 A MX 9806250A MX 9806250 A MX9806250 A MX 9806250A MX 9806250 A MX9806250 A MX 9806250A
Authority
MX
Mexico
Prior art keywords
hydrogen
alkyl
dihydrobenzofuran
alkoxy
hydroxy
Prior art date
Application number
MX9806250A
Other languages
English (en)
Inventor
Laurence Ichih Wu
John Michael Janusz
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of MX9806250A publication Critical patent/MX9806250A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Se describe un compuesto que tiene la estructura (Ver Formula); en donde; n es de 1 a aproximadamente 3; X se selecciona del grupo que consiste de O, S, SO, SO2; Y es independientemente hidrogeno o alquilo de cadena recta, ramificada o cíclica que tiene de 1 a aproximadamente 4 átomos de carbono; o las Y's son enlazadas entre sí para formar un anillo de alcanilo que tiene de 3 a 7 átomos distintos al hidrogeno; Z es hidrogeno o un alquilo de cadena recta, ramificada o cíclica que tiene de 3 a aproximadamente 10 átomos distintos al hidrogeno; R1 es hidrogeno o alquilo de cadena recta, ramificada o cíclica, halogeno, carboxilo, carboxamido, alcoxicarbonilo o alquilcarbonilo; T es O o S; U es O, S, N o N-R2; W es CR3R4, C=O, C=S, C=NR5, C-O-R6, C-S-R6, C-NH2, C-NHR7, o C-NR6R7; V es (CH2)n, O, S o N-R2; R2 es hidrogeno, alquilo, hidroxi, alcoxi, alcoxicarbonilo o alquilcarbonilo; R3 y R4 se seleccionan independientemente del grupo que consta de hidrogeno, alquilo, halogeno, hidroxi, alcoxi, mercapto, alquiltio o ciano; R5 es hidrogeno, alquilo, hidroxi o alcoxi; R6 es hidrogeno o alquilo; R7 es hidrogeno, alquilo o C(=NH)N(R6)2; también se describen composiciones farmacéuticas que comprenden dichos compuestos, así como métodos de tratamiento de inflamacion o dolor utilizando dichos compuestos.
MX9806250A 1996-02-01 1998-08-03 Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. MX9806250A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/595,337 US5618835A (en) 1996-02-01 1996-02-01 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
MX9806250A true MX9806250A (es) 1998-11-30

Family

ID=24382842

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9806250A MX9806250A (es) 1996-02-01 1998-08-03 Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.

Country Status (15)

Country Link
US (1) US5618835A (es)
EP (1) EP0888323B1 (es)
JP (1) JP3095424B2 (es)
KR (1) KR100322402B1 (es)
CN (1) CN1125062C (es)
AT (1) ATE267187T1 (es)
AU (1) AU730262B2 (es)
BR (1) BR9707247A (es)
CA (1) CA2244203A1 (es)
DE (1) DE69729183T2 (es)
DK (1) DK0888323T3 (es)
ES (1) ES2221950T3 (es)
MX (1) MX9806250A (es)
NO (1) NO983530L (es)
WO (1) WO1997028147A1 (es)

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AU7933298A (en) * 1997-06-27 1999-01-19 Kaneka Corporation Heat shock factor activity inhibitors
BR9812982A (pt) 1997-10-24 2000-08-08 Shionogi & Co Agente anti-reumático
US20040058873A1 (en) * 1998-03-12 2004-03-25 Esmond Robert W. Method for treating or preventing Alzheimer's disease
US6191154B1 (en) 1998-11-27 2001-02-20 Case Western Reserve University Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
CA2450660C (en) 2001-06-13 2011-08-16 Magnachem International Laboratories, Inc. Lactone formulations and method of use
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US8188145B2 (en) 2002-06-12 2012-05-29 Magnachem International Laboratories, Inc. Synthetic lactone formulations and method of use
CN102579427A (zh) 2002-11-05 2012-07-18 马格纳化学国际实验室公司 合成的内酯制剂及其使用方法
ES2315566T3 (es) * 2002-11-22 2009-04-01 Smithkline Beecham Corporation Tiazolidin-4-onas para inhibir proteinas hyak3.
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
PE20070083A1 (es) * 2005-06-08 2007-01-27 Smithkline Beecham Corp (5z)-5-(6-quinoxalinilmetilideno)-2-[(2,6-diclorofenil)amino]-1,3-tiazol-4(5h)-ona
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
US20100286041A1 (en) * 2007-03-22 2010-11-11 Smithkline Beecham Corporation (5z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5h)-one
WO2010048616A2 (en) 2008-10-24 2010-04-29 Magnachem International Laboratories, Inc. Method for screening for compounds selectively interacting with rad9
JP5483601B2 (ja) * 2009-01-27 2014-05-07 国立大学法人名古屋大学 膜張力測定装置
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
CN110075069A (zh) 2009-05-06 2019-08-02 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

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US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents

Also Published As

Publication number Publication date
ATE267187T1 (de) 2004-06-15
NO983530L (no) 1998-09-30
NO983530D0 (no) 1998-07-31
KR19990082222A (ko) 1999-11-25
EP0888323A1 (en) 1999-01-07
EP0888323B1 (en) 2004-05-19
KR100322402B1 (ko) 2002-05-09
ES2221950T3 (es) 2005-01-16
DE69729183D1 (de) 2004-06-24
CN1210530A (zh) 1999-03-10
AU1843397A (en) 1997-08-22
CA2244203A1 (en) 1997-08-07
CN1125062C (zh) 2003-10-22
BR9707247A (pt) 1999-07-20
AU730262B2 (en) 2001-03-01
JP3095424B2 (ja) 2000-10-03
DK0888323T3 (da) 2004-08-09
JPH11506121A (ja) 1999-06-02
US5618835A (en) 1997-04-08
WO1997028147A1 (en) 1997-08-07
DE69729183T2 (de) 2004-10-07

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: VANDERBILT UNIVERSITY

MM Annulment or lapse due to non-payment of fees