MX9701819A - Dihidrobenzofurano y compuestos relacionados, utiles como agentes antiiflamatorios. - Google Patents

Dihidrobenzofurano y compuestos relacionados, utiles como agentes antiiflamatorios.

Info

Publication number
MX9701819A
MX9701819A MX9701819A MX9701819A MX9701819A MX 9701819 A MX9701819 A MX 9701819A MX 9701819 A MX9701819 A MX 9701819A MX 9701819 A MX9701819 A MX 9701819A MX 9701819 A MX9701819 A MX 9701819A
Authority
MX
Mexico
Prior art keywords
carbon atoms
hydrogen
dihydrobenzofuran
branched
inflammatory agents
Prior art date
Application number
MX9701819A
Other languages
English (en)
Other versions
MXPA97001819A (es
Inventor
Michael Wiard Scherz
John Michael Janusz
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of MXPA97001819A publication Critical patent/MXPA97001819A/es
Publication of MX9701819A publication Critical patent/MX9701819A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/66—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto que tiene la estructura (A) en donde (a) W es -C(X')-NRR' o -NR-C(X')R'; (b) X y X' son independientemente O o S; (c) cada Y es un hidrogeno independiente o alcanilo recto, ramificado o cíclico no sustituido que tiene de 1 a 3 átomos de carbono, o las dos Y se encuentran unidas para formar un anillo alcanilo que tiene de 3 a 7 átomos de carbono; (d) Z es alquilo ramificado o cíclico no sustituido, o fenilo o bencilo no sustituido o alcanil sustituido, Z tiene de 3 a 10 átomos diferentes del hidrogeno; (e) R se selecciona de hidrogeno, alquilo recto o ramificado que tiene de 1 a aproximadamente 6 átomos de carbono y alquilo cíclico que tiene de 3 a aproximadamente 6 átomos de carbono; y (f) R' se selecciona de hidrogeno, hidroxi, alquilo o alcoxilo que tienen de 1 a aproximadamente 6 átomos de carbono, y alquilo cíclico con de 3 a aproximadamente 7 átomos de carbono; composiciones farmacéuticas que comprenden tales compuestos, y métodos para el tratamiento de la inflamacion o el dolor usando tales compuestos.
MX9701819A 1994-09-07 1995-09-06 Dihidrobenzofurano y compuestos relacionados, utiles como agentes antiiflamatorios. MX9701819A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30145694A 1994-09-07 1994-09-07
PCT/US1995/011309 WO1996007651A1 (en) 1994-09-07 1995-09-06 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US301456 1999-04-29

Publications (2)

Publication Number Publication Date
MXPA97001819A MXPA97001819A (es) 1997-06-01
MX9701819A true MX9701819A (es) 1997-06-28

Family

ID=23163447

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9701819A MX9701819A (es) 1994-09-07 1995-09-06 Dihidrobenzofurano y compuestos relacionados, utiles como agentes antiiflamatorios.

Country Status (15)

Country Link
US (1) US5684002A (es)
EP (1) EP0779886B1 (es)
JP (1) JPH10505089A (es)
KR (1) KR100249542B1 (es)
CN (1) CN1183126C (es)
AT (1) ATE210125T1 (es)
AU (1) AU682281B2 (es)
BR (1) BR9508901A (es)
CA (1) CA2199128C (es)
DE (1) DE69524428T2 (es)
DK (1) DK0779886T3 (es)
ES (1) ES2169150T3 (es)
MX (1) MX9701819A (es)
NZ (1) NZ292782A (es)
WO (1) WO1996007651A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684041A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5821250A (en) * 1996-02-01 1998-10-13 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5618835A (en) * 1996-02-01 1997-04-08 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5686471A (en) * 1996-02-01 1997-11-11 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5985930A (en) 1996-11-21 1999-11-16 Pasinetti; Giulio M. Treatment of neurodegenerative conditions with nimesulide
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
NZ544298A (en) * 2003-06-26 2009-04-30 Takeda Pharmaceutical Cannabinoid receptor modulators including benzofuran derivatives
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
EP2178371B1 (en) * 2007-07-13 2014-01-01 Board of Regents, The University of Texas System Heterocyclic modulators of cannabinoid receptors
US9079854B2 (en) 2007-07-13 2015-07-14 The Cleveland Clinic Foundation Hydrazone modulators of cannabinoid receptors
US9394267B2 (en) 2007-07-13 2016-07-19 The Cleveland Clinic Foundation Heterocyclic modulators of cannabinoid receptors
WO2009012227A1 (en) * 2007-07-13 2009-01-22 Board Of Regents, The University Of Texas System Hydrazone modulators of cannabinoid receptors
ES2728225T3 (es) 2009-02-20 2019-10-23 2 Bbb Medicines B V Sistema de administración de fármacos a base de glutatión
EP2427178B1 (en) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2014011949A2 (en) 2012-07-13 2014-01-16 The Cleveland Clinic Foundation Neuroprotective cb2 receptor agonists
KR101592560B1 (ko) * 2013-06-21 2016-02-05 제주대학교 산학협력단 신규 플라보노이드 및 그 용도
CN114133948A (zh) * 2021-12-29 2022-03-04 江苏三吉利化工股份有限公司 一种利用呋喃酚焦油制备橡胶油的方法
CN117624095A (zh) * 2023-11-28 2024-03-01 皖南医学院第一附属医院（皖南医学院弋矶山医院） 一种新型手性二氢苯并呋喃酰胺的合成方法及其应用

Family Cites Families (16)

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BE758838A (fr) * 1969-11-13 1971-05-12 Geigy Ag J R Esters d'acides carboxyliques heterocyliques et medicaments renfermant de telles substances
JPS6031829B2 (ja) * 1975-06-26 1985-07-24 ウェルファイド株式会社 アミノアルコ−ル誘導体の製造法
FR2332010A1 (fr) * 1975-11-18 1977-06-17 Continental Pharma Amino-alcool heterocyclique, son sel et son procede de preparation
JPS6019305B2 (ja) * 1976-07-02 1985-05-15 ウェルファイド株式会社 ジヒドロベンゾフラン誘導体
JPS603305B2 (ja) * 1976-12-27 1985-01-26 エーザイ株式会社 ２，３―ジハイドロベンゾフラン誘導体
US4130666A (en) * 1977-05-16 1978-12-19 Riker Laboratories, Inc. Anti-inflammatory method
IT1093805B (it) * 1978-01-31 1985-07-26 Erba Carlo Spa Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
DE3110009A1 (de) * 1981-03-11 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue benzofuran-derivate, ihre herstellung und verwendung
FI842738A (fi) * 1983-07-14 1985-01-15 Syntex Inc Aroylbenzofuran- och benzotiofenaettik- och propionsyror.
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
JPS61158976A (ja) * 1984-12-28 1986-07-18 Shionogi & Co Ltd ベンゾフランおよびベンゾチオフエン誘導体
US4708966A (en) * 1986-06-27 1987-11-24 The Procter & Gamble Company Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
IL88674A0 (en) * 1987-12-18 1989-07-31 Norwich Eaton Pharma Preparation of certain substituted aromatic compounds
JPH07121933B2 (ja) * 1988-03-28 1995-12-25 キッセイ薬品工業株式会社 ジヒドロベンゾフラノン誘導体
GB9322781D0 (en) * 1993-11-04 1993-12-22 Roussel Lab Ltd Aromatic amides

Also Published As

Publication number Publication date
US5684002A (en) 1997-11-04
EP0779886B1 (en) 2001-12-05
DK0779886T3 (da) 2002-03-11
ATE210125T1 (de) 2001-12-15
CN1183126C (zh) 2005-01-05
ES2169150T3 (es) 2002-07-01
CA2199128C (en) 2001-03-20
DE69524428D1 (de) 2002-01-17
WO1996007651A1 (en) 1996-03-14
EP0779886A1 (en) 1997-06-25
JPH10505089A (ja) 1998-05-19
BR9508901A (pt) 1998-01-06
DE69524428T2 (de) 2002-05-23
AU682281B2 (en) 1997-09-25
CN1157613A (zh) 1997-08-20
AU3505995A (en) 1996-03-27
NZ292782A (en) 1999-02-25
CA2199128A1 (en) 1996-03-14
KR970705553A (ko) 1997-10-09
KR100249542B1 (ko) 2000-04-01

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: VANDERBILT UNIVERSITY

MM Annulment or lapse due to non-payment of fees