MX9806251A - Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. - Google Patents

Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.

Info

Publication number
MX9806251A
MX9806251A MX9806251A MX9806251A MX9806251A MX 9806251 A MX9806251 A MX 9806251A MX 9806251 A MX9806251 A MX 9806251A MX 9806251 A MX9806251 A MX 9806251A MX 9806251 A MX9806251 A MX 9806251A
Authority
MX
Mexico
Prior art keywords
atoms
dihydrobenzofuran
inflammatory agents
compounds useful
related compounds
Prior art date
Application number
MX9806251A
Other languages
English (en)
Inventor
Michael Wiard Scherz
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of MX9806251A publication Critical patent/MX9806251A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Abstract

Un compuesto que tiene la estructura (I) (a) n es de 1 a aproximadamente 3; (b) x es seleccionada del grupo que consiste en O, S, SO, o SO2; (C) Y es independientemente hidrogeno o alquilo de cadena recta ramificada o cíclica que tiene de 1 a aproximadamente 4 átomos de carbono, o las Y están enlazadas para formar un anillo de alcanilo que tiene de 3 a aproximadamente 7 átomos; (d) 2 es hidrogeno o alquilo de cadena recta, ramificada o cíclica que tiene de 3 a aproximadamente 10 átomos distintos al hidrogeno; (e) W es 0 o 5, y (f) R1, R2 y R3 son independientemente hidrogeno, alquilo de cadena recta, ramificado o cíclico que tienen de 1 a 10 átomos de carbono, arilo, heterocíclico, heteroarilo, hidroxi o alcoxi; o R1, R2 o R3 pueden estar enlazadas para formar uno o más anillos cada anillo tiene de 3 a aproximadamente 7 átomos en los cuales de 1 a 3 átomos pueden ser heteroátomos; composiciones farmacéuticas que consisten en dichos compuestos, y métodos para el tratamiento de inflamacion o dolor utilizando dichos compuestos.
MX9806251A 1996-02-01 1998-08-03 Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. MX9806251A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/595,158 US5684041A (en) 1996-02-01 1996-02-01 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
MX9806251A true MX9806251A (es) 1998-11-30

Family

ID=24381988

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9806251A MX9806251A (es) 1996-02-01 1998-08-03 Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.

Country Status (16)

Country Link
US (1) US5684041A (es)
EP (1) EP0879231B1 (es)
JP (1) JP3095421B2 (es)
KR (1) KR100350920B1 (es)
CN (1) CN1097588C (es)
AT (1) ATE277031T1 (es)
AU (1) AU730319B2 (es)
BR (1) BR9707250A (es)
CA (1) CA2244194C (es)
DE (1) DE69730817T2 (es)
DK (1) DK0879231T3 (es)
ES (1) ES2229331T3 (es)
MX (1) MX9806251A (es)
NO (1) NO983525L (es)
NZ (1) NZ331618A (es)
WO (1) WO1997028143A1 (es)

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JPH0516948U (ja) * 1991-08-16 1993-03-02 湯浅起市郎 金属製板体の吊子構造
WO2003009815A2 (en) 2001-07-25 2003-02-06 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
NZ544298A (en) 2003-06-26 2009-04-30 Takeda Pharmaceutical Cannabinoid receptor modulators including benzofuran derivatives
GB0322016D0 (en) * 2003-09-19 2003-10-22 Merck Sharp & Dohme New compounds
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
ES2728225T3 (es) 2009-02-20 2019-10-23 2 Bbb Medicines B V Sistema de administración de fármacos a base de glutatión
AU2010245823B2 (en) 2009-05-06 2016-11-24 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
US11311528B2 (en) 2018-03-20 2022-04-26 Merck Sharp & Dohme Corp. Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors

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US3252999A (en) * 1963-11-01 1966-05-24 American Home Prod Derivatives of 5-amino-2, 3-dihydro-2-methyl benzofuran
US3963717A (en) * 1975-03-10 1976-06-15 Sandoz, Inc. Tricyclic furo-quinazolinones
JPS6019305B2 (ja) * 1976-07-02 1985-05-15 ウェルファイド株式会社 ジヒドロベンゾフラン誘導体
CH632268A5 (de) * 1977-01-14 1982-09-30 Sandoz Ag Verfahren zur herstellung von neuen heterocyclylaminoderivaten.
IT1093805B (it) * 1978-01-31 1985-07-26 Erba Carlo Spa Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
US4470440A (en) * 1982-09-30 1984-09-11 Thor Harry A Impact producing tool
JPS60108846A (ja) * 1983-11-18 1985-06-14 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料
AU556949B2 (en) * 1984-10-25 1986-11-27 Fmc Corporation Pyrozoline insecticides
US4767779A (en) * 1985-09-24 1988-08-30 Fmc Corporation Pyrazoline-1-carboxamides, composition containing them, and insecticidal method of using them
IT206464Z2 (it) * 1986-02-27 1987-08-10 Alfa Romeo Spa Impianto di scarico per un motore a c.i..
EP0273647B1 (en) * 1986-12-27 1992-03-11 Takeda Chemical Industries, Ltd. Coumaran derivatives, their production and use
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
DE3810080A1 (de) * 1988-03-25 1989-10-05 Bayer Ag Trisubstituierte 1,3,5-triazin-2,4,6-trione
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
US4975457A (en) * 1989-09-25 1990-12-04 Merck & Co., Inc. Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis
WO1991007396A1 (en) * 1989-11-17 1991-05-30 Meiji Milk Products Co., Ltd. Benzofuran derivative, process for preparing the same, and pharmaceutical comprising the same as active ingredient
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Also Published As

Publication number Publication date
AU730319B2 (en) 2001-03-01
KR19990082223A (ko) 1999-11-25
AU1842897A (en) 1997-08-22
BR9707250A (pt) 1999-04-06
DE69730817D1 (de) 2004-10-28
ES2229331T3 (es) 2005-04-16
JPH11503467A (ja) 1999-03-26
ATE277031T1 (de) 2004-10-15
CN1097588C (zh) 2003-01-01
NZ331618A (en) 2000-08-25
NO983525D0 (no) 1998-07-31
DE69730817T2 (de) 2005-02-03
EP0879231A1 (en) 1998-11-25
WO1997028143A1 (en) 1997-08-07
DK0879231T3 (da) 2004-12-20
KR100350920B1 (ko) 2002-11-18
CN1210529A (zh) 1999-03-10
US5684041A (en) 1997-11-04
EP0879231B1 (en) 2004-09-22
NO983525L (no) 1998-09-30
CA2244194C (en) 2003-05-06
JP3095421B2 (ja) 2000-10-03
CA2244194A1 (en) 1997-08-07

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: VANDERBILT UNIVERSITY

MM Annulment or lapse due to non-payment of fees