ATE277031T1 - Dihydrobenzofuranderivate verwendbar als entzündungshemmende mittel - Google Patents

Dihydrobenzofuranderivate verwendbar als entzündungshemmende mittel

Info

Publication number
ATE277031T1
ATE277031T1 AT97904014T AT97904014T ATE277031T1 AT E277031 T1 ATE277031 T1 AT E277031T1 AT 97904014 T AT97904014 T AT 97904014T AT 97904014 T AT97904014 T AT 97904014T AT E277031 T1 ATE277031 T1 AT E277031T1
Authority
AT
Austria
Prior art keywords
atoms
inflammatory agents
branched
straight
cyclic alkyl
Prior art date
Application number
AT97904014T
Other languages
English (en)
Inventor
Michael Wiard Scherz
Original Assignee
Univ Vanderbilt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Application granted granted Critical
Publication of ATE277031T1 publication Critical patent/ATE277031T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT97904014T 1996-02-01 1997-01-30 Dihydrobenzofuranderivate verwendbar als entzündungshemmende mittel ATE277031T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/595,158 US5684041A (en) 1996-02-01 1996-02-01 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
PCT/US1997/001308 WO1997028143A1 (en) 1996-02-01 1997-01-30 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
ATE277031T1 true ATE277031T1 (de) 2004-10-15

Family

ID=24381988

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97904014T ATE277031T1 (de) 1996-02-01 1997-01-30 Dihydrobenzofuranderivate verwendbar als entzündungshemmende mittel

Country Status (16)

Country Link
US (1) US5684041A (de)
EP (1) EP0879231B1 (de)
JP (1) JP3095421B2 (de)
KR (1) KR100350920B1 (de)
CN (1) CN1097588C (de)
AT (1) ATE277031T1 (de)
AU (1) AU730319B2 (de)
BR (1) BR9707250A (de)
CA (1) CA2244194C (de)
DE (1) DE69730817T2 (de)
DK (1) DK0879231T3 (de)
ES (1) ES2229331T3 (de)
MX (1) MX9806251A (de)
NO (1) NO983525L (de)
NZ (1) NZ331618A (de)
WO (1) WO1997028143A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0516948U (ja) * 1991-08-16 1993-03-02 湯浅起市郎 金属製板体の吊子構造
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CA2531020C (en) * 2003-06-26 2014-03-25 Takeda Pharmaceutical Company Limited Cannabinoid receptor modulator
GB0322016D0 (en) * 2003-09-19 2003-10-22 Merck Sharp & Dohme New compounds
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
EA024559B1 (ru) 2009-05-06 2016-09-30 Лаборэтори Скин Кэа, Инк. Композиции для нанесения на кератинизированную поверхность кожи млекопитающего и способ доставки
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2019182886A1 (en) * 2018-03-20 2019-09-26 Merck Sharp & Dohme Corp. Oxo-tetrahydro-isoquinoline carboxylic acids as sting inhibitors

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Publication number Priority date Publication date Assignee Title
US3252999A (en) * 1963-11-01 1966-05-24 American Home Prod Derivatives of 5-amino-2, 3-dihydro-2-methyl benzofuran
US3963717A (en) * 1975-03-10 1976-06-15 Sandoz, Inc. Tricyclic furo-quinazolinones
JPS6019305B2 (ja) * 1976-07-02 1985-05-15 ウェルファイド株式会社 ジヒドロベンゾフラン誘導体
CH632268A5 (de) * 1977-01-14 1982-09-30 Sandoz Ag Verfahren zur herstellung von neuen heterocyclylaminoderivaten.
IT1093805B (it) * 1978-01-31 1985-07-26 Erba Carlo Spa Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
US4470440A (en) * 1982-09-30 1984-09-11 Thor Harry A Impact producing tool
JPS60108846A (ja) * 1983-11-18 1985-06-14 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料
AU556949B2 (en) * 1984-10-25 1986-11-27 Fmc Corporation Pyrozoline insecticides
US4767779A (en) * 1985-09-24 1988-08-30 Fmc Corporation Pyrazoline-1-carboxamides, composition containing them, and insecticidal method of using them
IT206464Z2 (it) * 1986-02-27 1987-08-10 Alfa Romeo Spa Impianto di scarico per un motore a c.i..
DE3777366D1 (de) * 1986-12-27 1992-04-16 Takeda Chemical Industries Ltd 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
DE3810080A1 (de) * 1988-03-25 1989-10-05 Bayer Ag Trisubstituierte 1,3,5-triazin-2,4,6-trione
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
US4975457A (en) * 1989-09-25 1990-12-04 Merck & Co., Inc. Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis
EP0458970A4 (en) * 1989-11-17 1992-05-13 Meiji Milk Products Company Limited Benzofuran derivative, process for preparing the same, and pharmaceutical comprising the same as active ingredient
US5091533A (en) * 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
AU660277B2 (en) * 1990-03-27 1995-06-22 Smithkline Beecham Corporation 5-lipoxygenase inhibitors
WO1992012144A1 (fr) * 1990-12-28 1992-07-23 Teijin Limited Compose cyclique condense de benzoxa, son procede de production, et composition pharmaceutique le contenant
WO1993003011A1 (en) * 1991-08-08 1993-02-18 Yamanouchi Pharmaceutical Co., Ltd. Urea derivative
FR2682381B1 (fr) * 1991-10-10 1995-04-07 Rhone Poulenc Rorer Sa Derives de benzodiazepine, leur preparation et les medicaments les contenant.
US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents

Also Published As

Publication number Publication date
JPH11503467A (ja) 1999-03-26
NZ331618A (en) 2000-08-25
EP0879231B1 (de) 2004-09-22
BR9707250A (pt) 1999-04-06
MX9806251A (es) 1998-11-30
DE69730817D1 (de) 2004-10-28
DE69730817T2 (de) 2005-02-03
ES2229331T3 (es) 2005-04-16
JP3095421B2 (ja) 2000-10-03
KR100350920B1 (ko) 2002-11-18
DK0879231T3 (da) 2004-12-20
CA2244194A1 (en) 1997-08-07
CN1210529A (zh) 1999-03-10
NO983525L (no) 1998-09-30
EP0879231A1 (de) 1998-11-25
CA2244194C (en) 2003-05-06
US5684041A (en) 1997-11-04
WO1997028143A1 (en) 1997-08-07
AU1842897A (en) 1997-08-22
KR19990082223A (ko) 1999-11-25
CN1097588C (zh) 2003-01-01
NO983525D0 (no) 1998-07-31
AU730319B2 (en) 2001-03-01

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Legal Events

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