NO983525L - Dihydrobenzofuran og relaterte forbindelser anvendelig som anti-inflammatoriske midler - Google Patents

Dihydrobenzofuran og relaterte forbindelser anvendelig som anti-inflammatoriske midler

Info

Publication number
NO983525L
NO983525L NO983525A NO983525A NO983525L NO 983525 L NO983525 L NO 983525L NO 983525 A NO983525 A NO 983525A NO 983525 A NO983525 A NO 983525A NO 983525 L NO983525 L NO 983525L
Authority
NO
Norway
Prior art keywords
atoms
dihydrobenzofuran
branched
inflammatory agents
straight
Prior art date
Application number
NO983525A
Other languages
English (en)
Other versions
NO983525D0 (no
Inventor
Michael Wiard Scherz
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO983525D0 publication Critical patent/NO983525D0/no
Publication of NO983525L publication Critical patent/NO983525L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Abstract

En forbindelse som har struktur (I) hvor (a) n er fra l til ca. 3; (b) X velges fra gruppen bestående av O, S, SO eller S02; (c) Y er uavhengig hydrogen eller rett, forgrenet eller cyklisk alkyl med fra l til 4 karbonatomer, eller Yene er bundet sammen for å danne en alkanylring som har fra 3 til ca. 7 atomer; (d) Z er hydrogen eller rett, forgrenet eller cyklisk alkyl som har fra 3 til ca. 10 atomer forskjellig fra hydro- gen; (e) W er O eller S; og (f) R1( R2 og R3 er uavhen- gig hydrogen, rett, forgrenet eller cyklisk alkyl som har l til 10 karbonatomer, aryl, heterocyklyl, hetero- aryl, hydroksy eller alkoksy; eller Rlf Ra eller R3 kan være bundet for å danne en eller flere ringer, hvor hver ring har fra 3 til ca. 7 atomer, hvori i til 3 atomer kan være heteroatomer. Farmasøytiske sammensetninger som omfatter slike forbindelser og fremgangsmåter for å behandle inflammasjon eller smerte ved å bruke slike forbindelser.
NO983525A 1996-02-01 1998-07-31 Dihydrobenzofuran og relaterte forbindelser anvendelig som anti-inflammatoriske midler NO983525L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/595,158 US5684041A (en) 1996-02-01 1996-02-01 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
PCT/US1997/001308 WO1997028143A1 (en) 1996-02-01 1997-01-30 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (2)

Publication Number Publication Date
NO983525D0 NO983525D0 (no) 1998-07-31
NO983525L true NO983525L (no) 1998-09-30

Family

ID=24381988

Family Applications (1)

Application Number Title Priority Date Filing Date
NO983525A NO983525L (no) 1996-02-01 1998-07-31 Dihydrobenzofuran og relaterte forbindelser anvendelig som anti-inflammatoriske midler

Country Status (16)

Country Link
US (1) US5684041A (no)
EP (1) EP0879231B1 (no)
JP (1) JP3095421B2 (no)
KR (1) KR100350920B1 (no)
CN (1) CN1097588C (no)
AT (1) ATE277031T1 (no)
AU (1) AU730319B2 (no)
BR (1) BR9707250A (no)
CA (1) CA2244194C (no)
DE (1) DE69730817T2 (no)
DK (1) DK0879231T3 (no)
ES (1) ES2229331T3 (no)
MX (1) MX9806251A (no)
NO (1) NO983525L (no)
NZ (1) NZ331618A (no)
WO (1) WO1997028143A1 (no)

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JPH0516948U (ja) * 1991-08-16 1993-03-02 湯浅起市郎 金属製板体の吊子構造
WO2003009815A2 (en) 2001-07-25 2003-02-06 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CN1816536B (zh) * 2003-06-26 2012-12-26 武田药品工业株式会社 大麻素受体调节剂
GB0322016D0 (en) * 2003-09-19 2003-10-22 Merck Sharp & Dohme New compounds
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
EP3395372B1 (en) 2009-02-20 2022-04-06 EnhanX Biopharm Inc. Glutathione-based drug delivery system
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2019182886A1 (en) * 2018-03-20 2019-09-26 Merck Sharp & Dohme Corp. Oxo-tetrahydro-isoquinoline carboxylic acids as sting inhibitors

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US3963717A (en) * 1975-03-10 1976-06-15 Sandoz, Inc. Tricyclic furo-quinazolinones
JPS6019305B2 (ja) * 1976-07-02 1985-05-15 ウェルファイド株式会社 ジヒドロベンゾフラン誘導体
CH632268A5 (de) * 1977-01-14 1982-09-30 Sandoz Ag Verfahren zur herstellung von neuen heterocyclylaminoderivaten.
IT1093805B (it) * 1978-01-31 1985-07-26 Erba Carlo Spa Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
US4470440A (en) * 1982-09-30 1984-09-11 Thor Harry A Impact producing tool
JPS60108846A (ja) * 1983-11-18 1985-06-14 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料
AU556949B2 (en) * 1984-10-25 1986-11-27 Fmc Corporation Pyrozoline insecticides
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IT206464Z2 (it) * 1986-02-27 1987-08-10 Alfa Romeo Spa Impianto di scarico per un motore a c.i..
EP0273647B1 (en) * 1986-12-27 1992-03-11 Takeda Chemical Industries, Ltd. Coumaran derivatives, their production and use
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
DE3810080A1 (de) * 1988-03-25 1989-10-05 Bayer Ag Trisubstituierte 1,3,5-triazin-2,4,6-trione
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
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KR920701190A (ko) * 1989-11-17 1992-08-11 나까야마 히사시 벤조푸란유도체, 그의 제조법 및 이를 유효성분으로 하는 의약
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Also Published As

Publication number Publication date
DE69730817T2 (de) 2005-02-03
DE69730817D1 (de) 2004-10-28
JP3095421B2 (ja) 2000-10-03
CA2244194C (en) 2003-05-06
ATE277031T1 (de) 2004-10-15
ES2229331T3 (es) 2005-04-16
CN1210529A (zh) 1999-03-10
US5684041A (en) 1997-11-04
NZ331618A (en) 2000-08-25
KR100350920B1 (ko) 2002-11-18
JPH11503467A (ja) 1999-03-26
BR9707250A (pt) 1999-04-06
CA2244194A1 (en) 1997-08-07
AU730319B2 (en) 2001-03-01
NO983525D0 (no) 1998-07-31
KR19990082223A (ko) 1999-11-25
WO1997028143A1 (en) 1997-08-07
DK0879231T3 (da) 2004-12-20
MX9806251A (es) 1998-11-30
EP0879231B1 (en) 2004-09-22
EP0879231A1 (en) 1998-11-25
CN1097588C (zh) 2003-01-01
AU1842897A (en) 1997-08-22

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