DK0879231T3 - Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler - Google Patents

Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler

Info

Publication number
DK0879231T3
DK0879231T3 DK97904014T DK97904014T DK0879231T3 DK 0879231 T3 DK0879231 T3 DK 0879231T3 DK 97904014 T DK97904014 T DK 97904014T DK 97904014 T DK97904014 T DK 97904014T DK 0879231 T3 DK0879231 T3 DK 0879231T3
Authority
DK
Denmark
Prior art keywords
atoms
dihydrobenzofuran
branched
inflammatory agents
straight
Prior art date
Application number
DK97904014T
Other languages
English (en)
Inventor
Michael Wiard Scherz
Original Assignee
Univ Vanderbilt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Vanderbilt filed Critical Univ Vanderbilt
Application granted granted Critical
Publication of DK0879231T3 publication Critical patent/DK0879231T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK97904014T 1996-02-01 1997-01-30 Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler DK0879231T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/595,158 US5684041A (en) 1996-02-01 1996-02-01 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
EP97904014A EP0879231B1 (en) 1996-02-01 1997-01-30 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
DK0879231T3 true DK0879231T3 (da) 2004-12-20

Family

ID=24381988

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97904014T DK0879231T3 (da) 1996-02-01 1997-01-30 Dihydrobenzofuran og beslægtede forbindelser, der er nyttige som antiinflammatoriske midler

Country Status (16)

Country Link
US (1) US5684041A (da)
EP (1) EP0879231B1 (da)
JP (1) JP3095421B2 (da)
KR (1) KR100350920B1 (da)
CN (1) CN1097588C (da)
AT (1) ATE277031T1 (da)
AU (1) AU730319B2 (da)
BR (1) BR9707250A (da)
CA (1) CA2244194C (da)
DE (1) DE69730817T2 (da)
DK (1) DK0879231T3 (da)
ES (1) ES2229331T3 (da)
MX (1) MX9806251A (da)
NO (1) NO983525L (da)
NZ (1) NZ331618A (da)
WO (1) WO1997028143A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0516948U (ja) * 1991-08-16 1993-03-02 湯浅起市郎 金属製板体の吊子構造
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
SI1637527T1 (sl) 2003-06-26 2013-07-31 Takeda Pharmaceutical Company Limited Modulator kanabinoidnega receptorja
GB0322016D0 (en) * 2003-09-19 2003-10-22 Merck Sharp & Dohme New compounds
US7435837B2 (en) * 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US20050261347A1 (en) * 2003-10-24 2005-11-24 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
CA2969926C (en) 2009-02-20 2018-05-15 2-Bbb Medicines B.V. Glutathione-based drug delivery system
EP2427178B1 (en) 2009-05-06 2023-01-04 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP3768266A4 (en) * 2018-03-20 2021-12-22 Merck Sharp & Dohme Corp. OXO-TETRAHYDRO-ISOQUINOLINE CARBOXYLIC ACIDS AS STING PROTEIN INHIBITORS

Family Cites Families (23)

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Publication number Priority date Publication date Assignee Title
US3252999A (en) * 1963-11-01 1966-05-24 American Home Prod Derivatives of 5-amino-2, 3-dihydro-2-methyl benzofuran
US3963717A (en) * 1975-03-10 1976-06-15 Sandoz, Inc. Tricyclic furo-quinazolinones
JPS6019305B2 (ja) * 1976-07-02 1985-05-15 ウェルファイド株式会社 ジヒドロベンゾフラン誘導体
CH632268A5 (de) * 1977-01-14 1982-09-30 Sandoz Ag Verfahren zur herstellung von neuen heterocyclylaminoderivaten.
IT1093805B (it) * 1978-01-31 1985-07-26 Erba Carlo Spa Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
US4470440A (en) * 1982-09-30 1984-09-11 Thor Harry A Impact producing tool
JPS60108846A (ja) * 1983-11-18 1985-06-14 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料
AU556949B2 (en) * 1984-10-25 1986-11-27 Fmc Corporation Pyrozoline insecticides
US4767779A (en) * 1985-09-24 1988-08-30 Fmc Corporation Pyrazoline-1-carboxamides, composition containing them, and insecticidal method of using them
IT206464Z2 (it) * 1986-02-27 1987-08-10 Alfa Romeo Spa Impianto di scarico per un motore a c.i..
DE3777366D1 (de) * 1986-12-27 1992-04-16 Takeda Chemical Industries Ltd 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
DE3810080A1 (de) * 1988-03-25 1989-10-05 Bayer Ag Trisubstituierte 1,3,5-triazin-2,4,6-trione
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
US4975457A (en) * 1989-09-25 1990-12-04 Merck & Co., Inc. Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis
WO1991007396A1 (en) * 1989-11-17 1991-05-30 Meiji Milk Products Co., Ltd. Benzofuran derivative, process for preparing the same, and pharmaceutical comprising the same as active ingredient
US5091533A (en) * 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
CA2078126A1 (en) * 1990-03-27 1991-09-28 Jerry Leroy Adams 5-lipoxygenase inhibitors
ES2145743T3 (es) * 1990-12-28 2000-07-16 Teijin Ltd Compuesto de anillo condensado benzoxa, su produccion y composicion farmaceutica que lo contiene.
WO1993003011A1 (en) * 1991-08-08 1993-02-18 Yamanouchi Pharmaceutical Co., Ltd. Urea derivative
FR2682381B1 (fr) * 1991-10-10 1995-04-07 Rhone Poulenc Rorer Sa Derives de benzodiazepine, leur preparation et les medicaments les contenant.
US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents

Also Published As

Publication number Publication date
ATE277031T1 (de) 2004-10-15
DE69730817T2 (de) 2005-02-03
NO983525L (no) 1998-09-30
DE69730817D1 (de) 2004-10-28
US5684041A (en) 1997-11-04
JP3095421B2 (ja) 2000-10-03
EP0879231B1 (en) 2004-09-22
JPH11503467A (ja) 1999-03-26
CA2244194C (en) 2003-05-06
CN1097588C (zh) 2003-01-01
EP0879231A1 (en) 1998-11-25
MX9806251A (es) 1998-11-30
NO983525D0 (no) 1998-07-31
CN1210529A (zh) 1999-03-10
KR19990082223A (ko) 1999-11-25
CA2244194A1 (en) 1997-08-07
WO1997028143A1 (en) 1997-08-07
NZ331618A (en) 2000-08-25
ES2229331T3 (es) 2005-04-16
AU730319B2 (en) 2001-03-01
BR9707250A (pt) 1999-04-06
KR100350920B1 (ko) 2002-11-18
AU1842897A (en) 1997-08-22

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