MX9806253A - Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. - Google Patents

Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.

Info

Publication number
MX9806253A
MX9806253A MX9806253A MX9806253A MX9806253A MX 9806253 A MX9806253 A MX 9806253A MX 9806253 A MX9806253 A MX 9806253A MX 9806253 A MX9806253 A MX 9806253A MX 9806253 A MX9806253 A MX 9806253A
Authority
MX
Mexico
Prior art keywords
atoms
branched
dihydrobenzofuran
straight
cyclic alkyl
Prior art date
Application number
MX9806253A
Other languages
English (en)
Inventor
Zhuliang Chen
John Michael Janusz
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of MX9806253A publication Critical patent/MX9806253A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Se describe un compuesto que tiene la estructura (Ver Formula) en donde: n es de 1 a aproximadamente 3; X se selecciona del grupo que consiste de 0, S, SO, SO2; Y es independientemente hidrogeno o alquilo o aralquilo de cadena recta, ramificada o cíclica que tiene de 1 a aproximadamente 3 átomos de carbono; o las Y's son enlazadas entre sí para formar un anillo de alcanilo que tiene de 3 a 7 átomos, Z es hidrogeno o un alquilo de cadena recta, ramificada o cíclica que tiene de 3 a aproximadamente 10 átomos distintos al hidrogeno; R1 y R2 son cada uno independientemente hidrogeno o alquilo de cadena recta, ramificada o cíclica, no substituido o substituido, carboxilo, carboxamido, alcoxicarbonilo o alquilcarbonilo; y Het es un grupo heteroarilo que comprende uno o más anillos que contienen de alrededor de 5 a aproximadamente 8 átomos en los anillos y en donde por lo menos un anillo tiene por lo menos un átomo heterogéneo seleccionado de O, N o S; también se describen composiciones farmacéuticas que comprenden dichos compuestos, así como métodos de tratamiento de inflamacion o dolor utilizando dichos compuestos.
MX9806253A 1996-02-01 1998-08-03 Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. MX9806253A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/595,120 US5686471A (en) 1996-02-01 1996-02-01 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
MX9806253A true MX9806253A (es) 1998-11-30

Family

ID=24381819

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9806253A MX9806253A (es) 1996-02-01 1998-08-03 Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.

Country Status (15)

Country Link
US (1) US5686471A (es)
EP (1) EP0904272B1 (es)
JP (1) JP3164157B2 (es)
KR (1) KR100322943B1 (es)
CN (1) CN1072668C (es)
AT (1) ATE236900T1 (es)
AU (1) AU730292B2 (es)
BR (1) BR9707342A (es)
CA (1) CA2244199A1 (es)
DE (1) DE69720718T2 (es)
DK (1) DK0904272T3 (es)
ES (1) ES2196301T3 (es)
MX (1) MX9806253A (es)
NO (1) NO983528L (es)
WO (1) WO1997028155A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
DE102004002235B4 (de) * 2004-01-15 2007-04-26 OCé PRINTING SYSTEMS GMBH Puffereinrichtung mit einem Vorratspuffer zur Aufnahme einer mit variierender Geschwindigkeit zugeführten Bedruckstoffbahn bei einer elektrografischen Druckeinrichtung
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(rap)-접합체 투여에 의한 간 질환의 치료
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑-磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019305B2 (ja) * 1976-07-02 1985-05-15 ウェルファイド株式会社 ジヒドロベンゾフラン誘導体
IT1093805B (it) * 1978-01-31 1985-07-26 Erba Carlo Spa Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
US4470440A (en) * 1982-09-30 1984-09-11 Thor Harry A Impact producing tool
EP0273647B1 (en) * 1986-12-27 1992-03-11 Takeda Chemical Industries, Ltd. Coumaran derivatives, their production and use
US5234926A (en) * 1987-03-20 1993-08-10 Allergan, Inc. Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity
US4849428A (en) * 1987-11-23 1989-07-18 The Procter & Gamble Company Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規2―置換クマラン誘導体
US4966907A (en) * 1988-08-12 1990-10-30 Merck & Co., Inc. 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis
FR2645537B1 (fr) * 1989-04-05 1994-03-04 Fabre Medicament Pierre Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique
US4975457A (en) * 1989-09-25 1990-12-04 Merck & Co., Inc. Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis
EP0458970A4 (en) * 1989-11-17 1992-05-13 Meiji Milk Products Company Limited Benzofuran derivative, process for preparing the same, and pharmaceutical comprising the same as active ingredient
US5091533A (en) * 1990-03-12 1992-02-25 Merck Frosst Canada, Inc. 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors
WO1991014674A2 (en) * 1990-03-27 1991-10-03 Smithkline Beecham Corporation 5-lipoxygenase inhibitors
ES2301161T3 (es) * 1994-07-27 2008-06-16 Vanderbilt University Compuestos de dihidrobenzofurano y compuestos relacionados utiles como agentes anti-inflamatorios.
US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents

Also Published As

Publication number Publication date
AU1843197A (en) 1997-08-22
ATE236900T1 (de) 2003-04-15
NO983528L (no) 1998-09-28
JPH11503468A (ja) 1999-03-26
US5686471A (en) 1997-11-11
CN1072668C (zh) 2001-10-10
DE69720718T2 (de) 2003-12-18
DK0904272T3 (da) 2003-07-21
KR100322943B1 (ko) 2002-05-09
CN1210534A (zh) 1999-03-10
DE69720718D1 (de) 2003-05-15
WO1997028155A1 (en) 1997-08-07
KR19990082225A (ko) 1999-11-25
ES2196301T3 (es) 2003-12-16
CA2244199A1 (en) 1997-08-07
BR9707342A (pt) 1999-07-20
EP0904272A1 (en) 1999-03-31
JP3164157B2 (ja) 2001-05-08
NO983528D0 (no) 1998-07-31
AU730292B2 (en) 2001-03-01
EP0904272B1 (en) 2003-04-09

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: VANDERBILT UNIVERSITY

MM Annulment or lapse due to non-payment of fees