MX9806253A - Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. - Google Patents
Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.Info
- Publication number
- MX9806253A MX9806253A MX9806253A MX9806253A MX9806253A MX 9806253 A MX9806253 A MX 9806253A MX 9806253 A MX9806253 A MX 9806253A MX 9806253 A MX9806253 A MX 9806253A MX 9806253 A MX9806253 A MX 9806253A
- Authority
- MX
- Mexico
- Prior art keywords
- atoms
- branched
- dihydrobenzofuran
- straight
- cyclic alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Se describe un compuesto que tiene la estructura (Ver Formula) en donde: n es de 1 a aproximadamente 3; X se selecciona del grupo que consiste de 0, S, SO, SO2; Y es independientemente hidrogeno o alquilo o aralquilo de cadena recta, ramificada o cíclica que tiene de 1 a aproximadamente 3 átomos de carbono; o las Y's son enlazadas entre sí para formar un anillo de alcanilo que tiene de 3 a 7 átomos, Z es hidrogeno o un alquilo de cadena recta, ramificada o cíclica que tiene de 3 a aproximadamente 10 átomos distintos al hidrogeno; R1 y R2 son cada uno independientemente hidrogeno o alquilo de cadena recta, ramificada o cíclica, no substituido o substituido, carboxilo, carboxamido, alcoxicarbonilo o alquilcarbonilo; y Het es un grupo heteroarilo que comprende uno o más anillos que contienen de alrededor de 5 a aproximadamente 8 átomos en los anillos y en donde por lo menos un anillo tiene por lo menos un átomo heterogéneo seleccionado de O, N o S; también se describen composiciones farmacéuticas que comprenden dichos compuestos, así como métodos de tratamiento de inflamacion o dolor utilizando dichos compuestos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/595,120 US5686471A (en) | 1996-02-01 | 1996-02-01 | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9806253A true MX9806253A (es) | 1998-11-30 |
Family
ID=24381819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9806253A MX9806253A (es) | 1996-02-01 | 1998-08-03 | Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5686471A (es) |
EP (1) | EP0904272B1 (es) |
JP (1) | JP3164157B2 (es) |
KR (1) | KR100322943B1 (es) |
CN (1) | CN1072668C (es) |
AT (1) | ATE236900T1 (es) |
AU (1) | AU730292B2 (es) |
BR (1) | BR9707342A (es) |
CA (1) | CA2244199A1 (es) |
DE (1) | DE69720718T2 (es) |
DK (1) | DK0904272T3 (es) |
ES (1) | ES2196301T3 (es) |
MX (1) | MX9806253A (es) |
NO (1) | NO983528L (es) |
WO (1) | WO1997028155A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
DE102004002235B4 (de) * | 2004-01-15 | 2007-04-26 | OCé PRINTING SYSTEMS GMBH | Puffereinrichtung mit einem Vorratspuffer zur Aufnahme einer mit variierender Geschwindigkeit zugeführten Bedruckstoffbahn bei einer elektrografischen Druckeinrichtung |
CN103259027A (zh) | 2005-04-28 | 2013-08-21 | 普罗透斯数字保健公司 | 药物信息系统 |
KR20090071598A (ko) | 2006-09-18 | 2009-07-01 | 랩터 파마슈티컬 인코포레이티드 | 수용체 결합 단백질(rap)-접합체 투여에 의한 간 질환의 치료 |
PT2398500T (pt) | 2009-02-20 | 2019-06-14 | 2 Bbb Medicines B V | Sistema de entrega de medicamentos à base de glutationas |
TWI556839B (zh) | 2009-05-06 | 2016-11-11 | 研究室護膚股份有限公司 | 包含活性劑-磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6019305B2 (ja) * | 1976-07-02 | 1985-05-15 | ウェルファイド株式会社 | ジヒドロベンゾフラン誘導体 |
IT1093805B (it) * | 1978-01-31 | 1985-07-26 | Erba Carlo Spa | Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione |
US4470440A (en) * | 1982-09-30 | 1984-09-11 | Thor Harry A | Impact producing tool |
EP0273647B1 (en) * | 1986-12-27 | 1992-03-11 | Takeda Chemical Industries, Ltd. | Coumaran derivatives, their production and use |
US5234926A (en) * | 1987-03-20 | 1993-08-10 | Allergan, Inc. | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
US4849428A (en) * | 1987-11-23 | 1989-07-18 | The Procter & Gamble Company | Cyclic anti-inflammatory derivatives of di-tert-butylphenol compounds, compositions and use |
JP2855341B2 (ja) * | 1988-06-10 | 1999-02-10 | 武田薬品工業株式会社 | 新規2―置換クマラン誘導体 |
US4966907A (en) * | 1988-08-12 | 1990-10-30 | Merck & Co., Inc. | 6-substituted 5-hydroxy-2,3-dihydrobenzofurans as inhibitors of leukotriene biosynthesis |
FR2645537B1 (fr) * | 1989-04-05 | 1994-03-04 | Fabre Medicament Pierre | Nouveaux sulfonamides derives d'acides benzocycliques ou benzoheterocycliques, leur preparation et leur application en therapeutique |
US4975457A (en) * | 1989-09-25 | 1990-12-04 | Merck & Co., Inc. | Trans 2,3-disubstituted-2,3-dihydro-5-hydroxy-benzofurans as inhibitors of leukotriene biosynthesis |
EP0458970A4 (en) * | 1989-11-17 | 1992-05-13 | Meiji Milk Products Company Limited | Benzofuran derivative, process for preparing the same, and pharmaceutical comprising the same as active ingredient |
US5091533A (en) * | 1990-03-12 | 1992-02-25 | Merck Frosst Canada, Inc. | 5-hydroxy-2,3-dihydrobenzofuran analogs as leukotriene biosynthesis inhibitors |
WO1991014674A2 (en) * | 1990-03-27 | 1991-10-03 | Smithkline Beecham Corporation | 5-lipoxygenase inhibitors |
ES2301161T3 (es) * | 1994-07-27 | 2008-06-16 | Vanderbilt University | Compuestos de dihidrobenzofurano y compuestos relacionados utiles como agentes anti-inflamatorios. |
US5684002A (en) * | 1994-09-07 | 1997-11-04 | The Procter & Gamble Company | Dihydorbenzofuran and related compounds useful as anti-inflammatory agents |
-
1996
- 1996-02-01 US US08/595,120 patent/US5686471A/en not_active Expired - Fee Related
-
1997
- 1997-01-30 CA CA002244199A patent/CA2244199A1/en not_active Abandoned
- 1997-01-30 DE DE69720718T patent/DE69720718T2/de not_active Expired - Fee Related
- 1997-01-30 KR KR1019980705953A patent/KR100322943B1/ko not_active IP Right Cessation
- 1997-01-30 ES ES97904017T patent/ES2196301T3/es not_active Expired - Lifetime
- 1997-01-30 DK DK97904017T patent/DK0904272T3/da active
- 1997-01-30 EP EP97904017A patent/EP0904272B1/en not_active Expired - Lifetime
- 1997-01-30 AT AT97904017T patent/ATE236900T1/de not_active IP Right Cessation
- 1997-01-30 JP JP52776097A patent/JP3164157B2/ja not_active Expired - Fee Related
- 1997-01-30 CN CN97192017A patent/CN1072668C/zh not_active Expired - Fee Related
- 1997-01-30 BR BR9707342A patent/BR9707342A/pt not_active Application Discontinuation
- 1997-01-30 AU AU18431/97A patent/AU730292B2/en not_active Ceased
- 1997-01-30 WO PCT/US1997/001312 patent/WO1997028155A1/en active IP Right Grant
-
1998
- 1998-07-31 NO NO983528A patent/NO983528L/no not_active Application Discontinuation
- 1998-08-03 MX MX9806253A patent/MX9806253A/es not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU1843197A (en) | 1997-08-22 |
ATE236900T1 (de) | 2003-04-15 |
NO983528L (no) | 1998-09-28 |
JPH11503468A (ja) | 1999-03-26 |
US5686471A (en) | 1997-11-11 |
CN1072668C (zh) | 2001-10-10 |
DE69720718T2 (de) | 2003-12-18 |
DK0904272T3 (da) | 2003-07-21 |
KR100322943B1 (ko) | 2002-05-09 |
CN1210534A (zh) | 1999-03-10 |
DE69720718D1 (de) | 2003-05-15 |
WO1997028155A1 (en) | 1997-08-07 |
KR19990082225A (ko) | 1999-11-25 |
ES2196301T3 (es) | 2003-12-16 |
CA2244199A1 (en) | 1997-08-07 |
BR9707342A (pt) | 1999-07-20 |
EP0904272A1 (en) | 1999-03-31 |
JP3164157B2 (ja) | 2001-05-08 |
NO983528D0 (no) | 1998-07-31 |
AU730292B2 (en) | 2001-03-01 |
EP0904272B1 (en) | 2003-04-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
PD | Change of proprietorship |
Owner name: VANDERBILT UNIVERSITY |
|
MM | Annulment or lapse due to non-payment of fees |