MX9806249A - Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. - Google Patents

Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.

Info

Publication number
MX9806249A
MX9806249A MX9806249A MX9806249A MX9806249A MX 9806249 A MX9806249 A MX 9806249A MX 9806249 A MX9806249 A MX 9806249A MX 9806249 A MX9806249 A MX 9806249A MX 9806249 A MX9806249 A MX 9806249A
Authority
MX
Mexico
Prior art keywords
branched
dihydrobenzofuran
straight
cyclic alkyl
hydrogen
Prior art date
Application number
MX9806249A
Other languages
English (en)
Inventor
James Madison Ridgeway Iii
John Michael Janusz
Original Assignee
Procter 6 Gamble Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter 6 Gamble Company filed Critical Procter 6 Gamble Company
Publication of MX9806249A publication Critical patent/MX9806249A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Se describe un compuesto que tiene la estructura (Ver Formula) en donde, n es de 1 a aproximadamente 3, X se selecciona del grupo que consiste de 0, S, SO, SO2; y es independientemente hidrogeno o alquilo o aralquilo de cadena recta, ramificada o cíclica que tiene de 1 aproximadamente 4 átomos de carbono; o las Y's son enlazadas entre sí para formar un anillo de alcanilo que tiene de 3 a 7 átomos; Z es hidrogeno o un alquilo de cadena recta, ramificada o cíclica que tiene de 3 a aproximadamente 10 átomos distintos al hidrogeno; R1 es hidrogeno o alquilo de cadena recta, ramificada o cíclica, arilo o C(=N)=NHR4; y R2, R3 y R4 son independientemente hidrogeno, alquilo de cadena recta, ramificada o cíclica que tiene de 1 a 10 átomos de carbono, o arilo; R2 y R3 se pueden enlazar entre sí para formar un anillo que tiene 5 o 6 átomos; también se describen composiciones farmacéuticas que comprenden dichos compuestos, así como métodos de tratamiento de inflamacion o dolor utilizando dichos compuestos.
MX9806249A 1996-02-01 1998-08-03 Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios. MX9806249A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/595,122 US5684031A (en) 1996-02-01 1996-02-01 Dihydrobenzofuran and related compounds useful as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
MX9806249A true MX9806249A (es) 1998-11-30

Family

ID=24381828

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9806249A MX9806249A (es) 1996-02-01 1998-08-03 Dihidrobenzofurano y compuestos relacionados utiles como agentes antiinflamatorios.

Country Status (15)

Country Link
US (1) US5684031A (es)
EP (1) EP0904270B1 (es)
JP (1) JP3095423B2 (es)
KR (1) KR100322400B1 (es)
CN (1) CN1109680C (es)
AT (1) ATE250594T1 (es)
AU (1) AU730263B2 (es)
BR (1) BR9707321A (es)
CA (1) CA2244402C (es)
DE (1) DE69725133T2 (es)
DK (1) DK0904270T3 (es)
ES (1) ES2208872T3 (es)
MX (1) MX9806249A (es)
NO (1) NO983527L (es)
WO (1) WO1997028145A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866579A (en) * 1997-04-11 1999-02-02 Synaptic Pharmaceutical Corporation Imidazole and imidazoline derivatives and uses thereof
WO2003009815A2 (en) 2001-07-25 2003-02-06 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
SI1889198T1 (sl) 2005-04-28 2015-02-27 Proteus Digital Health, Inc. Farma-informacijski sistem
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
ES2728225T3 (es) 2009-02-20 2019-10-23 2 Bbb Medicines B V Sistema de administración de fármacos a base de glutatión
AU2010245823B2 (en) 2009-05-06 2016-11-24 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

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FR2332010A1 (fr) * 1975-11-18 1977-06-17 Continental Pharma Amino-alcool heterocyclique, son sel et son procede de preparation
FR2370472A2 (fr) * 1976-11-10 1978-06-09 Continental Pharma Amino-alcool heterocyclique, son sel et son procede de preparation
CH615031A5 (es) * 1976-04-30 1979-12-28 Gretag Ag
JPS6019305B2 (ja) * 1976-07-02 1985-05-15 ウェルファイド株式会社 ジヒドロベンゾフラン誘導体
JPS603305B2 (ja) * 1976-12-27 1985-01-26 エーザイ株式会社 ２，３―ジハイドロベンゾフラン誘導体
US4398028A (en) * 1977-01-14 1983-08-09 Sandoz Ltd. Bicyclic heterocyclic amino derivatives
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IT1093805B (it) * 1978-01-31 1985-07-26 Erba Carlo Spa Derivati del 2h-benzofuran-3-one e procedimento per la loro preparazione
EP0026593A1 (en) * 1979-09-15 1981-04-08 Pfizer Limited Bicyclic keto- and amino- acids, esters and amides and pharmaceutical compositions thereof
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Also Published As

Publication number Publication date
EP0904270A1 (en) 1999-03-31
ATE250594T1 (de) 2003-10-15
KR100322400B1 (ko) 2002-05-09
JPH11506120A (ja) 1999-06-02
NO983527L (no) 1998-09-28
US5684031A (en) 1997-11-04
CA2244402C (en) 2003-10-07
DE69725133D1 (de) 2003-10-30
ES2208872T3 (es) 2004-06-16
JP3095423B2 (ja) 2000-10-03
DK0904270T3 (da) 2003-12-01
EP0904270B1 (en) 2003-09-24
CA2244402A1 (en) 1997-08-07
CN1109680C (zh) 2003-05-28
WO1997028145A1 (en) 1997-08-07
NO983527D0 (no) 1998-07-31
AU730263B2 (en) 2001-03-01
CN1210532A (zh) 1999-03-10
KR19990082220A (ko) 1999-11-25
BR9707321A (pt) 1999-04-13
DE69725133T2 (de) 2004-07-15
AU1843097A (en) 1997-08-22

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Legal Events

Date Code Title Description
FG Grant or registration
PD Change of proprietorship

Owner name: VANDERBILT UNIVERSITY

MM Annulment or lapse due to non-payment of fees