NO973035L - Hydroksaminsyre-holdige inhibitorer for matriks-metallproteaser - Google Patents

Hydroksaminsyre-holdige inhibitorer for matriks-metallproteaser

Info

Publication number
NO973035L
NO973035L NO973035A NO973035A NO973035L NO 973035 L NO973035 L NO 973035L NO 973035 A NO973035 A NO 973035A NO 973035 A NO973035 A NO 973035A NO 973035 L NO973035 L NO 973035L
Authority
NO
Norway
Prior art keywords
matrix metal
hydroxamic acid
containing inhibitors
metal proteases
proteases
Prior art date
Application number
NO973035A
Other languages
English (en)
Other versions
NO973035D0 (no
Inventor
Kenneth Edward Yelm
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO973035D0 publication Critical patent/NO973035D0/no
Publication of NO973035L publication Critical patent/NO973035L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oppfinnelsen tilveiebringer hydroksaminsyre-holdige forbindelser som er anvendbare som inhibitorer for matriks- metallproteaser og som er effektive ved behandling av tilstander assosiert med overdreven aktivitet av disse enzymene. Den foreliggende oppfinnelse vedrører særlig en forbindelse som har en struktur i samsvar med formel (I), hvori: (A) R^, R^, R^, R"* og R^ er uavhengig valgt fra ulike substituenter, og (B) hvor R^ og R'' eller R'' og R^ kan sammen utgjøre en cyklisk del, eller et farmasøytisk akseptabelt salt, biohydrolyserbart amid eller biohydrolyserbar ester derav. I andre aspekter er oppfinnelsen rettet på farma- søytiske preparater inneholdende forbindelsene med formel (I) , og metoder for behandling av sykdonamer karakterisert ved matriks-metallproteaseaktivitet ved anvendelse av disse forbindelsene eller de farmasøytiske preparatene inneholdende disse. HO- (I)
NO973035A 1994-12-29 1997-06-27 Hydroksaminsyre-holdige inhibitorer for matriks-metallproteaser NO973035L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/366,062 US5639746A (en) 1994-12-29 1994-12-29 Hydroxamic acid-containing inhibitors of matrix metalloproteases
PCT/US1995/016140 WO1996020918A1 (en) 1994-12-29 1995-12-13 Hydroxamic acid-containing inhibitors of matrix metalloproteases

Publications (2)

Publication Number Publication Date
NO973035D0 NO973035D0 (no) 1997-06-27
NO973035L true NO973035L (no) 1997-08-29

Family

ID=23441517

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973035A NO973035L (no) 1994-12-29 1997-06-27 Hydroksaminsyre-holdige inhibitorer for matriks-metallproteaser

Country Status (11)

Country Link
US (1) US5639746A (no)
EP (1) EP0800510A1 (no)
JP (1) JPH10512241A (no)
KR (1) KR980700963A (no)
CN (1) CN1171780A (no)
AU (1) AU706409B2 (no)
BR (1) BR9510175A (no)
CA (1) CA2208679A1 (no)
NO (1) NO973035L (no)
NZ (1) NZ298677A (no)
WO (1) WO1996020918A1 (no)

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NZ334252A (en) * 1996-08-28 2000-11-24 Procter & Gamble Heterocyclic metalloprotease inhibitors
WO1998015525A1 (fr) * 1996-10-07 1998-04-16 Sumitomo Pharmaceuticals Co., Ltd. Acides hydroxamiques
US20030206874A1 (en) * 1996-11-21 2003-11-06 The Proctor & Gamble Company Promoting whole body health
AUPO721997A0 (en) * 1997-06-06 1997-07-03 Queensland Institute Of Medical Research, The Anticancer compounds
US6846478B1 (en) 1998-02-27 2005-01-25 The Procter & Gamble Company Promoting whole body health
US6569636B2 (en) * 1998-05-29 2003-05-27 Hawaii Biotechnology Group, Inc. Assay for modulators of metallo-enzyme activity
HRP990246A2 (en) * 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
GB9818605D0 (en) 1998-08-26 1998-10-21 Glaxo Group Ltd Formamide compounds as therepeutic agents
US6329400B1 (en) 1998-08-26 2001-12-11 Glaxo Wellcome Inc. Formamide compounds as therapeutic agents
US6172064B1 (en) 1998-08-26 2001-01-09 Glaxo Wellcome Inc. Formamides as therapeutic agents
EP1313426A4 (en) 1998-12-24 2003-05-28 Bristol Myers Squibb Pharma Co SUCCINOYLAMINOBENZODIAZEPINE AS INHIBITORS OF A-BETA PROTEIN PRODUCTION
AU4180900A (en) 1999-04-02 2000-10-23 Du Pont Pharmaceuticals Company Novel amide derivatives as inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
AU7997600A (en) 1999-10-08 2001-04-23 Du Pont Pharmaceuticals Company Amino lactam sulfonamides as inhibitors of abeta protein production
EP1261610A2 (en) 2000-02-17 2002-12-04 Bristol-Myers Squibb Pharma Company Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production
US6495540B2 (en) 2000-03-28 2002-12-17 Bristol - Myers Squibb Pharma Company Lactams as inhibitors of A-β protein production
BR0110051A (pt) 2000-04-03 2004-12-07 Bristol Myers Squibb Pharma Co Composto, uso do composto, composição farmacêutica e método de tratamento do mal de alzheimer
US6759404B2 (en) * 2000-04-03 2004-07-06 Richard E. Olson Cyclic malonamides as inhibitors of aβ protein production
CA2404273A1 (en) 2000-04-11 2001-10-18 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of a.beta. protein production
WO2001092235A1 (en) 2000-06-01 2001-12-06 Bristol-Myers Squibb Pharma Company LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
EP1294383B1 (en) * 2000-06-30 2008-07-16 The Procter & Gamble Company Oral compositions comprising antimicrobial agents for the prevention of systemic diseases
DE60134854D1 (de) * 2000-06-30 2008-08-28 Procter & Gamble Orale zubereitungen, die wirtsantwortmodulierenden wirkstoffe enthalten
US8283135B2 (en) 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
WO2003101381A2 (en) * 2002-05-29 2003-12-11 Merck & Co., Inc. 1,2 diamido cycloalkyl sodium channel blockers
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
KR101155335B1 (ko) * 2005-01-07 2012-06-11 엘지전자 주식회사 이동통신 단말기의 멀티미디어 메시지 동작방법
TWI465251B (zh) * 2008-01-08 2014-12-21 Lantheus Medical Imaging Inc 作為顯影劑的ｎ－烷氧基醯胺共軛物
AU2010271097B2 (en) 2009-07-08 2015-12-10 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents

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Also Published As

Publication number Publication date
US5639746A (en) 1997-06-17
CA2208679A1 (en) 1996-07-11
AU4422096A (en) 1996-07-24
AU706409B2 (en) 1999-06-17
BR9510175A (pt) 1997-10-14
MX9704968A (es) 1997-10-31
JPH10512241A (ja) 1998-11-24
WO1996020918A1 (en) 1996-07-11
NZ298677A (en) 1999-03-29
CN1171780A (zh) 1998-01-28
NO973035D0 (no) 1997-06-27
KR980700963A (ko) 1998-04-30
EP0800510A1 (en) 1997-10-15

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