NO973035L - Hydroksaminsyre-holdige inhibitorer for matriks-metallproteaser - Google Patents

Hydroksaminsyre-holdige inhibitorer for matriks-metallproteaser

Info

Publication number
NO973035L
NO973035L NO973035A NO973035A NO973035L NO 973035 L NO973035 L NO 973035L NO 973035 A NO973035 A NO 973035A NO 973035 A NO973035 A NO 973035A NO 973035 L NO973035 L NO 973035L
Authority
NO
Norway
Prior art keywords
matrix metal
hydroxamic acid
containing inhibitors
metal proteases
proteases
Prior art date
Application number
NO973035A
Other languages
English (en)
Other versions
NO973035D0 (no
Inventor
Kenneth Edward Yelm
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO973035D0 publication Critical patent/NO973035D0/no
Publication of NO973035L publication Critical patent/NO973035L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oppfinnelsen tilveiebringer hydroksaminsyre-holdige forbindelser som er anvendbare som inhibitorer for matriks- metallproteaser og som er effektive ved behandling av tilstander assosiert med overdreven aktivitet av disse enzymene. Den foreliggende oppfinnelse vedrører særlig en forbindelse som har en struktur i samsvar med formel (I), hvori: (A) R^, R^, R^, R"* og R^ er uavhengig valgt fra ulike substituenter, og (B) hvor R^ og R'' eller R'' og R^ kan sammen utgjøre en cyklisk del, eller et farmasøytisk akseptabelt salt, biohydrolyserbart amid eller biohydrolyserbar ester derav. I andre aspekter er oppfinnelsen rettet på farma- søytiske preparater inneholdende forbindelsene med formel (I) , og metoder for behandling av sykdonamer karakterisert ved matriks-metallproteaseaktivitet ved anvendelse av disse forbindelsene eller de farmasøytiske preparatene inneholdende disse. HO- (I)
NO973035A 1994-12-29 1997-06-27 Hydroksaminsyre-holdige inhibitorer for matriks-metallproteaser NO973035L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/366,062 US5639746A (en) 1994-12-29 1994-12-29 Hydroxamic acid-containing inhibitors of matrix metalloproteases
PCT/US1995/016140 WO1996020918A1 (en) 1994-12-29 1995-12-13 Hydroxamic acid-containing inhibitors of matrix metalloproteases

Publications (2)

Publication Number Publication Date
NO973035D0 NO973035D0 (no) 1997-06-27
NO973035L true NO973035L (no) 1997-08-29

Family

ID=23441517

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973035A NO973035L (no) 1994-12-29 1997-06-27 Hydroksaminsyre-holdige inhibitorer for matriks-metallproteaser

Country Status (11)

Country Link
US (1) US5639746A (no)
EP (1) EP0800510A1 (no)
JP (1) JPH10512241A (no)
KR (1) KR980700963A (no)
CN (1) CN1171780A (no)
AU (1) AU706409B2 (no)
BR (1) BR9510175A (no)
CA (1) CA2208679A1 (no)
NO (1) NO973035L (no)
NZ (1) NZ298677A (no)
WO (1) WO1996020918A1 (no)

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US6846478B1 (en) 1998-02-27 2005-01-25 The Procter & Gamble Company Promoting whole body health
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NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
US6172064B1 (en) 1998-08-26 2001-01-09 Glaxo Wellcome Inc. Formamides as therapeutic agents
GB9818605D0 (en) 1998-08-26 1998-10-21 Glaxo Group Ltd Formamide compounds as therepeutic agents
US6329400B1 (en) 1998-08-26 2001-12-11 Glaxo Wellcome Inc. Formamide compounds as therapeutic agents
EP1313426A2 (en) 1998-12-24 2003-05-28 Bristol-Myers Squibb Pharma Company Succinoylamino benzodiazepines as inhibitors of a-beta protein production
EP1165500A1 (en) 1999-04-02 2002-01-02 Du Pont Pharmaceuticals Company Amide derivatives as inhibitors of matrix metalloproteinases,tnf-alpha,and aggrecanase
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
WO2001027091A1 (en) 1999-10-08 2001-04-19 Du Pont Pharmaceuticals Company AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6525044B2 (en) 2000-02-17 2003-02-25 Bristol-Myers Squibb Company Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
US6495540B2 (en) 2000-03-28 2002-12-17 Bristol - Myers Squibb Pharma Company Lactams as inhibitors of A-β protein production
CA2403550A1 (en) 2000-04-03 2001-10-11 Hong Liu Cyclic lactams as inhibitors of a-.beta. protein production
BR0107532A (pt) * 2000-04-03 2004-11-03 Bristol Myers Squibb Pharma Co Composto, uso do composto, método para o tratamento de disfunções neurológicas associadas com a produção de b-amilóide, método de inibição da atividade de y-secretase e composição farmacêutica
US6632812B2 (en) 2000-04-11 2003-10-14 Dupont Pharmaceuticals Company Substituted lactams as inhibitors of Aβ protein production
BR0106717A (pt) 2000-06-01 2002-04-16 Bristol Myers Squibb Pharma Co Compostos, composição farmacêutica e usos dos compostos de lactama inovadora
US8283135B2 (en) 2000-06-30 2012-10-09 The Procter & Gamble Company Oral care compositions containing combinations of anti-bacterial and host-response modulating agents
CA2415068C (en) * 2000-06-30 2009-03-10 The Procter & Gamble Company Oral compositions comprising antimicrobial agents
MXPA03000043A (es) * 2000-06-30 2003-10-15 Procter & Gamble Promocion de la salud en todo el cuerpo.
WO2003101381A2 (en) * 2002-05-29 2003-12-11 Merck & Co., Inc. 1,2 diamido cycloalkyl sodium channel blockers
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
KR101155335B1 (ko) * 2005-01-07 2012-06-11 엘지전자 주식회사 이동통신 단말기의 멀티미디어 메시지 동작방법
KR101861025B1 (ko) 2008-01-08 2018-05-24 랜티우스 메디컬 이메징, 인크. 영상화 제제로서의 ｎ-알콕시아미드 접합체
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Also Published As

Publication number Publication date
NO973035D0 (no) 1997-06-27
CN1171780A (zh) 1998-01-28
BR9510175A (pt) 1997-10-14
NZ298677A (en) 1999-03-29
AU4422096A (en) 1996-07-24
WO1996020918A1 (en) 1996-07-11
JPH10512241A (ja) 1998-11-24
KR980700963A (ko) 1998-04-30
MX9704968A (es) 1997-10-31
US5639746A (en) 1997-06-17
CA2208679A1 (en) 1996-07-11
AU706409B2 (en) 1999-06-17
EP0800510A1 (en) 1997-10-15

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