DK0927161T3 - Substitueret cyklisk amin-metalloproteaseinhibitorer - Google Patents
Substitueret cyklisk amin-metalloproteaseinhibitorerInfo
- Publication number
- DK0927161T3 DK0927161T3 DK97938412T DK97938412T DK0927161T3 DK 0927161 T3 DK0927161 T3 DK 0927161T3 DK 97938412 T DK97938412 T DK 97938412T DK 97938412 T DK97938412 T DK 97938412T DK 0927161 T3 DK0927161 T3 DK 0927161T3
- Authority
- DK
- Denmark
- Prior art keywords
- cyclic amine
- substituted cyclic
- metalloprotease inhibitors
- compounds
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/42—Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2484296P | 1996-08-28 | 1996-08-28 | |
PCT/US1997/014555 WO1998008815A1 (en) | 1996-08-28 | 1997-08-22 | Substituted cyclic amine metalloprotease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0927161T3 true DK0927161T3 (da) | 2003-02-17 |
Family
ID=21822685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK97938412T DK0927161T3 (da) | 1996-08-28 | 1997-08-22 | Substitueret cyklisk amin-metalloproteaseinhibitorer |
Country Status (30)
Country | Link |
---|---|
US (6) | US6417219B1 (da) |
EP (1) | EP0927161B1 (da) |
JP (2) | JP3541043B2 (da) |
KR (1) | KR100323272B1 (da) |
CN (1) | CN1232451A (da) |
AT (1) | ATE226193T1 (da) |
AU (1) | AU741893B2 (da) |
BR (1) | BR9713465A (da) |
CA (1) | CA2263928A1 (da) |
CO (1) | CO4900036A1 (da) |
CZ (1) | CZ63199A3 (da) |
DE (1) | DE69716449T2 (da) |
DK (1) | DK0927161T3 (da) |
ES (1) | ES2201318T3 (da) |
HK (1) | HK1020962A1 (da) |
HU (1) | HUP0000478A3 (da) |
ID (1) | ID18143A (da) |
IL (1) | IL128666A (da) |
MY (1) | MY116959A (da) |
NO (1) | NO315371B1 (da) |
NZ (1) | NZ334256A (da) |
PE (1) | PE109098A1 (da) |
PL (1) | PL331802A1 (da) |
PT (1) | PT927161E (da) |
RU (1) | RU2221782C2 (da) |
SK (1) | SK25099A3 (da) |
TR (1) | TR199900431T2 (da) |
TW (1) | TWI232218B (da) |
WO (1) | WO1998008815A1 (da) |
ZA (1) | ZA977698B (da) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6500948B1 (en) | 1995-12-08 | 2002-12-31 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof |
CA2238306A1 (en) * | 1995-12-08 | 1997-06-12 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation |
US20020128476A1 (en) * | 1996-08-08 | 2002-09-12 | Smithkline Beecham Corporation | Inhibitors of cysteine protease |
US6872742B2 (en) * | 1996-08-28 | 2005-03-29 | The Procter & Gamble Company | Substituted cyclic amine metalloprotease inhibitors |
IL128666A (en) * | 1996-08-28 | 2005-09-25 | Procter & Gamble | Substituted cyclic amine metalloprotease inhibitors |
US6174915B1 (en) | 1997-03-25 | 2001-01-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
US6008243A (en) * | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
ZA98376B (en) * | 1997-01-23 | 1998-07-23 | Hoffmann La Roche | Sulfamide-metalloprotease inhibitors |
PL334997A1 (en) | 1997-02-11 | 2000-03-27 | Pfizer | Derivatives or arylosulphonyl-hydroxamic acid |
US5985900A (en) * | 1997-04-01 | 1999-11-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
AU7294098A (en) * | 1997-05-09 | 1998-11-27 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
EP1009737A2 (en) | 1997-07-31 | 2000-06-21 | The Procter & Gamble Company | Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors |
US6130220A (en) * | 1997-10-16 | 2000-10-10 | Syntex (Usa) Inc. | Sulfamide-metalloprotease inhibitors |
EP1053226A1 (en) | 1998-02-04 | 2000-11-22 | Novartis AG | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
US6410580B1 (en) | 1998-02-04 | 2002-06-25 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
US6329418B1 (en) | 1998-04-14 | 2001-12-11 | The Procter & Gamble Company | Substituted pyrrolidine hydroxamate metalloprotease inhibitors |
BR9910678A (pt) | 1998-05-14 | 2001-10-02 | Du Pont Pharm Co | Composto, composição farmacêutica, método para traramento ou prevenção de uma doença inflamatória, método para tratamento de uma condição ou uma doença mediada por mmps, tnf, agrecanase, ou um composto dos mesmos, em um mamìfero, método de redução de nìveis de tnf em pacientes, sem a inibição de mmps, método para tratamento de uma condição ou uma doença e uso de um novo composto |
UA59453C2 (uk) * | 1998-08-12 | 2003-09-15 | Пфайзер Продактс Інк. | Похідні гідроксипіпеколат гідроксамової кислоти як інгібітори матричних металопротеїназ |
US6300341B1 (en) | 1998-09-30 | 2001-10-09 | The Procter & Gamble Co. | 2-substituted heterocyclic sulfonamides |
JP2002525305A (ja) * | 1998-09-30 | 2002-08-13 | ザ、プロクター、エンド、ギャンブル、カンパニー | スルホンアミドを用いた脱毛治療の方法 |
US6307049B1 (en) | 1998-09-30 | 2001-10-23 | The Procter & Gamble Co. | Heterocyclic 2-substituted ketoamides |
US6200996B1 (en) | 1999-01-27 | 2001-03-13 | American Cyanamid Company | Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors |
US6762178B2 (en) | 1999-01-27 | 2004-07-13 | Wyeth Holdings Corporation | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
AR035313A1 (es) * | 1999-01-27 | 2004-05-12 | Wyeth Corp | Inhibidores de tace acetilenicos de acido hidroxamico de sulfonamida a base de alfa-aminoacidos, composiciones farmaceuticas y el uso de los mismos para la manufactura de medicamentos. |
US6753337B2 (en) | 1999-01-27 | 2004-06-22 | Wyeth Holdings Corporation | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors |
US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
US6946473B2 (en) | 1999-01-27 | 2005-09-20 | Wyeth Holdings Corporation | Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors |
US6340691B1 (en) | 1999-01-27 | 2002-01-22 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors |
US6225311B1 (en) | 1999-01-27 | 2001-05-01 | American Cyanamid Company | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors |
US6277885B1 (en) | 1999-01-27 | 2001-08-21 | American Cyanamid Company | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
WO2000044723A1 (en) | 1999-01-27 | 2000-08-03 | American Cyanamid Company | Alkynyl containing hydroxamic acid derivatives, their preparation and their use as matrix metalloproteinase (mmp) inhibitors/tnf-alpha converting enzyme (tace) inhibitors |
US6326516B1 (en) | 1999-01-27 | 2001-12-04 | American Cyanamid Company | Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors |
NZ513830A (en) | 1999-03-03 | 2001-09-28 | Procter & Gamble | Dihetero-substituted metalloprotease inhibitors |
CN1349498A (zh) | 1999-03-03 | 2002-05-15 | 宝洁公司 | 含有链烯基和炔基的金属蛋白酶抑制剂 |
WO2000058304A1 (fr) * | 1999-03-26 | 2000-10-05 | Shionogi & Co., Ltd. | Derives sulfonamides heterocycliques |
AU6499000A (en) * | 1999-08-05 | 2001-03-05 | Procter & Gamble Company, The | Multivalent compounds |
AU6388500A (en) * | 1999-08-05 | 2001-03-05 | Procter & Gamble Company, The | Multivalent sulfonamides |
EP1081137A1 (en) | 1999-08-12 | 2001-03-07 | Pfizer Products Inc. | Selective inhibitors of aggrecanase in osteoarthritis treatment |
US6143776A (en) * | 2000-02-02 | 2000-11-07 | Sunesis Pharmaceuticals, Inc. | Tosylproline analogs as thymidylate synthase inhibitors |
US6458822B2 (en) | 2000-03-13 | 2002-10-01 | Pfizer Inc. | 2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases |
CN1481377A (zh) | 2000-03-17 | 2004-03-10 | ����˹�ж�-����˹˹����ҩƷ��˾ | 作为基质金属蛋白酶和TNF-α的抑制剂的环β-氨基酸衍生物 |
EP1138680A1 (en) | 2000-03-29 | 2001-10-04 | Pfizer Products Inc. | Gem substituted sulfonyl hydroxamic acids as MMP inhibitors |
KR100372757B1 (ko) * | 2000-04-07 | 2003-02-17 | 삼성전자주식회사 | 메트릭스 메탈로프로테이나제의 저해제로서의 설폰아미드유도체 |
WO2002002096A2 (en) | 2000-06-30 | 2002-01-10 | The Procter & Gamble Company | Oral compositions comprising host-response modulating agent |
US8283135B2 (en) | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
CN1620433A (zh) * | 2000-07-19 | 2005-05-25 | 霍夫曼-拉罗奇有限公司 | 作为内皮肽转化酶抑制剂的吡咯烷衍生物 |
CN100406439C (zh) * | 2000-07-19 | 2008-07-30 | 霍夫曼-拉罗奇有限公司 | 作为金属蛋白酶抑制剂的吡咯烷衍生物 |
US6444829B1 (en) * | 2000-07-19 | 2002-09-03 | Hoffmann-La Roche Inc. | Pyrrolidine compounds |
FR2819252A1 (fr) * | 2001-01-11 | 2002-07-12 | Servier Lab | Nouveaux derives d'acide hydroxamique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
JP4825375B2 (ja) | 2001-08-28 | 2011-11-30 | 株式会社 資生堂 | ジチアゾール化合物及びマトリックスメタロプロテアーゼ活性阻害剤、皮膚外用剤 |
CN1610661A (zh) | 2001-11-01 | 2005-04-27 | 惠氏控股公司 | 用作基质金属蛋白酶和tace的抑制剂的丙二烯芳基磺酰胺异羟肟酸 |
WO2003042176A1 (fr) | 2001-11-13 | 2003-05-22 | Shiseido Co., Ltd. | Compose azabicyclo, inhibiteur de metalloprotease matricielle et preparation cutanee |
WO2003059265A2 (en) * | 2001-12-21 | 2003-07-24 | Cytokinetics, Inc. | Compositions and methods for treating heart failure |
US7199155B2 (en) | 2002-12-23 | 2007-04-03 | Wyeth Holdings Corporation | Acetylenic aryl sulfonate hydroxamic acid TACE and matrix metalloproteinase inhibitors |
US8088737B2 (en) | 2003-04-04 | 2012-01-03 | Incyte Corporation | Compositions, methods and kits relating to Her-2 cleavage |
US20040258769A1 (en) * | 2003-06-20 | 2004-12-23 | Barker Ronnie C. | Use of ocular vitamins in conjunction with other treatment methods for AMD |
CN1294120C (zh) * | 2003-10-21 | 2007-01-10 | 山东大学 | 吡咯烷类基质金属蛋白酶抑制剂及其应用 |
DE102004031620A1 (de) * | 2004-06-30 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | 4-Trifluormethoxyphenoxybenzol-4`-sulfonsäuren, Verfahren zu ihrer Herstellung und Verwendung in Arzneimitteln |
ES2402362T3 (es) | 2004-09-30 | 2013-05-03 | Takeda Pharmaceutical Company Limited | Inhibidores de la bomba de protones |
JP2008530197A (ja) * | 2005-02-18 | 2008-08-07 | イノディア インク. | 4−ヒドロキシイソロイシンの類似体及びその使用 |
PT2327692E (pt) | 2005-08-30 | 2012-10-11 | Takeda Pharmaceutical | Derivados de 1h-pirrole substituídos com 1-heterociclilsulfonilo, 2-aminometilo, 5-(hetero)arilo como inibidores da secreção ácida |
NZ569293A (en) | 2005-12-23 | 2011-10-28 | Zealand Pharma As | Modified lysine-mimetic compounds |
US8933105B2 (en) | 2007-02-28 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
ES2330291B1 (es) | 2008-02-29 | 2010-10-18 | Lipotec Sa | Peptidos utiles en el tratamiento de la piel, mucosas y/o cuero cabelludo y su uso en composiciones cosmeticas o farmaceuticas. |
UY32074A (es) | 2008-08-27 | 2010-03-26 | Takeda Pharmaceutical | Compuestos de pirrol |
ES2349972B1 (es) | 2009-02-16 | 2011-11-24 | Lipotec, S.A. | Péptidos útiles en el tratamiento y/o cuidado de la piel, mucosas y/o cuero cabelludo y su uso en composiciones cosméticas o farmacéuticas. |
KR20140072894A (ko) * | 2011-10-04 | 2014-06-13 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 신규의 세포사멸 유도 화합물 |
EP3515888B1 (en) | 2016-09-20 | 2021-03-31 | GlaxoSmithKline Intellectual Property (No. 2) Limited | Trpv4 antagonists |
TW201825458A (zh) | 2016-09-20 | 2018-07-16 | 英商葛蘭素史克智慧財產(第二)有限公司 | Trpv4拮抗劑 |
WO2018055527A1 (en) | 2016-09-20 | 2018-03-29 | Glaxosmithkline Intellectual Property (No.2) Limited | Trpv4 antagonists |
WO2018202865A1 (en) | 2017-05-05 | 2018-11-08 | Zealand Pharma A/S | Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4954158A (en) * | 1983-08-16 | 1990-09-04 | University Of Georgia Research Foundation, Inc. | 2,3-methanoproline |
ZA877471B (en) * | 1986-10-08 | 1988-04-05 | Bristol-Myers Company | 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents |
US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
WO1996033172A1 (en) * | 1995-04-20 | 1996-10-24 | Pfizer Inc. | Arylsulfonyl hydroxamic acid derivatives as mmp and tnf inhibitors |
KR100266467B1 (ko) * | 1995-09-27 | 2000-10-02 | 우에노 도시오 | 설폰아미드 유도체 |
CA2238306A1 (en) * | 1995-12-08 | 1997-06-12 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparation |
FR2743073B1 (fr) * | 1995-12-29 | 1998-02-20 | Fournier Ind & Sante | Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique |
FR2743562B1 (fr) * | 1996-01-11 | 1998-04-03 | Sanofi Sa | Derives de n-(arylsulfonyl) aminoacides, leur preparation, les compositions pharmaceutiques en contenant |
IL128666A (en) * | 1996-08-28 | 2005-09-25 | Procter & Gamble | Substituted cyclic amine metalloprotease inhibitors |
US6376506B1 (en) * | 1997-01-23 | 2002-04-23 | Syntex (U.S.A.) Llc | Sulfamide-metalloprotease inhibitors |
ZA98376B (en) * | 1997-01-23 | 1998-07-23 | Hoffmann La Roche | Sulfamide-metalloprotease inhibitors |
US6261775B1 (en) * | 1999-04-09 | 2001-07-17 | The Regents Of The University Of California | Detection of chromosome copy number changes to distinguish melanocytic nevi from malignant melanoma |
-
1997
- 1997-08-22 IL IL12866697A patent/IL128666A/xx not_active IP Right Cessation
- 1997-08-22 CZ CZ99631A patent/CZ63199A3/cs unknown
- 1997-08-22 ES ES97938412T patent/ES2201318T3/es not_active Expired - Lifetime
- 1997-08-22 CA CA002263928A patent/CA2263928A1/en not_active Abandoned
- 1997-08-22 TR TR1999/00431T patent/TR199900431T2/xx unknown
- 1997-08-22 WO PCT/US1997/014555 patent/WO1998008815A1/en active IP Right Grant
- 1997-08-22 AT AT97938412T patent/ATE226193T1/de not_active IP Right Cessation
- 1997-08-22 JP JP51171598A patent/JP3541043B2/ja not_active Expired - Fee Related
- 1997-08-22 PT PT97938412T patent/PT927161E/pt unknown
- 1997-08-22 HU HU0000478A patent/HUP0000478A3/hu unknown
- 1997-08-22 DK DK97938412T patent/DK0927161T3/da active
- 1997-08-22 NZ NZ334256A patent/NZ334256A/xx unknown
- 1997-08-22 RU RU99106522/04A patent/RU2221782C2/ru not_active IP Right Cessation
- 1997-08-22 PL PL97331802A patent/PL331802A1/xx unknown
- 1997-08-22 SK SK250-99A patent/SK25099A3/sk unknown
- 1997-08-22 DE DE69716449T patent/DE69716449T2/de not_active Expired - Fee Related
- 1997-08-22 EP EP97938412A patent/EP0927161B1/en not_active Expired - Lifetime
- 1997-08-22 KR KR1019997001658A patent/KR100323272B1/ko not_active IP Right Cessation
- 1997-08-22 BR BR9713465-1A patent/BR9713465A/pt not_active Application Discontinuation
- 1997-08-22 CN CN97198539A patent/CN1232451A/zh active Pending
- 1997-08-22 AU AU40741/97A patent/AU741893B2/en not_active Ceased
- 1997-08-26 US US08/918,317 patent/US6417219B1/en not_active Expired - Fee Related
- 1997-08-27 MY MYPI97003949A patent/MY116959A/en unknown
- 1997-08-27 CO CO97049510A patent/CO4900036A1/es unknown
- 1997-08-27 ZA ZA9707698A patent/ZA977698B/xx unknown
- 1997-08-28 PE PE1997000768A patent/PE109098A1/es not_active Application Discontinuation
- 1997-08-28 ID IDP972994A patent/ID18143A/id unknown
-
1998
- 1998-02-03 TW TW087101301A patent/TWI232218B/zh not_active IP Right Cessation
-
1999
- 1999-02-23 NO NO19990855A patent/NO315371B1/no unknown
-
2000
- 2000-01-04 HK HK00100036A patent/HK1020962A1/xx not_active IP Right Cessation
-
2001
- 2001-06-25 US US09/888,759 patent/US20020072517A1/en not_active Abandoned
- 2001-06-25 US US09/888,675 patent/US6569855B2/en not_active Expired - Fee Related
-
2002
- 2002-12-03 US US10/308,780 patent/US6858628B2/en not_active Expired - Fee Related
-
2003
- 2003-11-13 JP JP2003384116A patent/JP2004115531A/ja not_active Withdrawn
-
2004
- 2004-12-03 US US11/003,884 patent/US20050154019A1/en not_active Abandoned
- 2004-12-03 US US11/003,594 patent/US20050101567A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0927161T3 (da) | Substitueret cyklisk amin-metalloproteaseinhibitorer | |
PT966465E (pt) | Inibidores do enzima imfdh | |
EA200100992A1 (ru) | Ингибиторы фермента impdh | |
TR200402157T2 (tr) | Heteroaril süksinamidler ve metalloproteinaz inhibitörü olarak kullanımları | |
EA200100867A1 (ru) | Сульфаматогидроксамовая кислота как ингибитор металлопротеаз | |
EA200100972A1 (ru) | Новые соединения и композиции как ингибиторы протеаз | |
FI942423A (fi) | Sakkariinijohdannisia proteolyyttisen entsyymin inhibiittoreina | |
BR0109353A (pt) | Cadeia lateral heterocìclica contendo inibidores de metaloprotease | |
ATE232873T1 (de) | Phosphonsaürederivate als ptp-1b-inhibitoren | |
IL128691A0 (en) | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants | |
BR9909620A (pt) | Inibidores de metaloproteases de hidroxamato de pirrolidina substituìdo | |
NO990896L (no) | Bidentate metalloproteaseinhibitorer | |
EA199900632A1 (ru) | 2-амино-6-(2-замещенные-4-фенокси)-замещенные-пиридины | |
BR0009244A (pt) | Inibidores de metaloprotease di-hétero substituìdos | |
BR0109328A (pt) | Inibidores de metaloprotease n-substituìdos, contendo cadeia lateral heterocìclica | |
CA2266759A1 (en) | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase | |
BR0109348A (pt) | Inibidores de metaloproteases n-substituìdos os quais contêm cadeias laterais carbocìclicas | |
WO2001091796A8 (en) | Methods, compounds and compositions for treating gout | |
DE60329326D1 (de) | Tace inhibitoren | |
TR200003065T2 (tr) | Nöraminidazların inhibitörleri olarak pirolidinler. | |
BR0014759A (pt) | Inibidores de metaloprotease beta dissubstituìdos | |
PL333421A1 (en) | 1-(3-aminoindazol-5-yl)-3-butyl cyclic ureas useful as inhibitors of hiv protease | |
BR0109354A (pt) | Inibidores de metaloproteases os quais contêm cadeias laterais carbocìclicas | |
MX9704968A (es) | Inhibidores que contienen acido hidroxamico de metaloproteasas de matriz. | |
ES2173634T3 (es) | Compuestos heterociclicos que presentan actividad inhibidora de mmp y tnf. |