NO992463L - N-(aryl/heteroarylacetyl)aminosyreestere, farmas°ytiske sammensetninger som innbefatter det samme, og fremgangsmÕter for inhibering av <beta>-amyloidpeptidfrigivelse og/eller dens syntese ved anvendelse av slike forbindelser - Google Patents

N-(aryl/heteroarylacetyl)aminosyreestere, farmas°ytiske sammensetninger som innbefatter det samme, og fremgangsmÕter for inhibering av <beta>-amyloidpeptidfrigivelse og/eller dens syntese ved anvendelse av slike forbindelser

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Publication number
NO992463L
NO992463L NO992463A NO992463A NO992463L NO 992463 L NO992463 L NO 992463L NO 992463 A NO992463 A NO 992463A NO 992463 A NO992463 A NO 992463A NO 992463 L NO992463 L NO 992463L
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Norway
Prior art keywords
synthesis
pharmaceutical compositions
compounds
methods
heteroarylacetyl
Prior art date
Application number
NO992463A
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English (en)
Other versions
NO992463D0 (no
Inventor
Jing Wu
Jay S Tung
Jeffrey S Nissen
Thomas E Mabry
Lee H Latimer
Clark Norman Eid
James E Audia
Original Assignee
Elan Pharm Inc
Lilly Co Eli
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Application filed by Elan Pharm Inc, Lilly Co Eli filed Critical Elan Pharm Inc
Publication of NO992463D0 publication Critical patent/NO992463D0/no
Publication of NO992463L publication Critical patent/NO992463L/no

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07C233/00—Carboxylic acid amides
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    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/37—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
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    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/39—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
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    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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Abstract

Fremlagt er forbindelser som inhiberer C-amyloidpeptidfrigivelse og/eller dets syntese, og følgelig har anvendelse ved behandling av Alzheimers sykdom. Det er også fremlagt farmasøytiske sammensetninger som innbefatter en forbindelse som inhiberer fl- amyloidpeptidfrigivelse og/eller dets syntese så vel som fremgangsmåter for behandling av Alzheimers sykdom både profylaktisk og terapeutisk med slike farmasøytiske sammensetninger.
NO992463A 1996-11-22 1999-05-21 N-(aryl/heteroarylacetyl)aminosyreestere, farmas°ytiske sammensetninger som innbefatter det samme, og fremgangsmÕter for inhibering av <beta>-amyloidpeptidfrigivelse og/eller dens syntese ved anvendelse av slike forbindelser NO992463L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75489596A 1996-11-22 1996-11-22
PCT/US1997/020355 WO1998022430A1 (en) 1996-11-22 1997-11-20 N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING b-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS

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AU739035B2 (en) 2001-10-04
KR20000069074A (ko) 2000-11-25
TR199901128T2 (xx) 1999-07-21
CA2267065A1 (en) 1998-05-28
NZ334950A (en) 2001-03-30
DE69733272D1 (de) 2005-06-16
NO992463D0 (no) 1999-05-21
CN1237960A (zh) 1999-12-08
DE69733272T2 (de) 2006-01-26
JP2001505204A (ja) 2001-04-17
EP0951464A1 (en) 1999-10-27
IL129238A0 (en) 2000-02-17
BR9713404A (pt) 2000-01-25
AU5249898A (en) 1998-06-10
ID21956A (id) 1999-08-19
HUP0000492A1 (hu) 2000-05-28
ATE295346T1 (de) 2005-05-15
WO1998022430A1 (en) 1998-05-28
EP0951464B1 (en) 2005-05-11
HUP0000492A3 (en) 2000-06-28

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