HUP0000492A1 - N-(Aril/heteroaril-acetil)-aminosav-észterek, azokat tartalmazó gyógyászati készítmények, valamint módszerek béta-amiloid fehérje képződése és felszabadulása gátlására e vegyületek felhasználásával - Google Patents
N-(Aril/heteroaril-acetil)-aminosav-észterek, azokat tartalmazó gyógyászati készítmények, valamint módszerek béta-amiloid fehérje képződése és felszabadulása gátlására e vegyületek felhasználásávalInfo
- Publication number
- HUP0000492A1 HUP0000492A1 HU0000492A HUP0000492A HUP0000492A1 HU P0000492 A1 HUP0000492 A1 HU P0000492A1 HU 0000492 A HU0000492 A HU 0000492A HU P0000492 A HUP0000492 A HU P0000492A HU P0000492 A1 HUP0000492 A1 HU P0000492A1
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- methods
- heteroarylacetyl
- aryl
- synthesis
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- -1 amino acid esters Chemical class 0.000 title 1
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 230000003449 preventive effect Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/51—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
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- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A jelen találmány tárgya a -amilőid fehérje képződését ésfelszabadűlását gátló vegyületek, amelyek, ennek megfelelően,hatásősak Alzheimer-kór kezelésében. A találmány tárgya tővábbá a -amilőid peptid felszabadűlását és/vagy képződését gátló vegyületettartalmazó gyógyászati készítmények, valamint módszerek ilyengyógyászati készítmények felhasználására Alzheimer-kór gyógyító ésmegelőző kezelésében. ŕ
Applications Claiming Priority (1)
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US75489596A | 1996-11-22 | 1996-11-22 |
Publications (2)
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HUP0000492A1 true HUP0000492A1 (hu) | 2000-05-28 |
HUP0000492A3 HUP0000492A3 (en) | 2000-06-28 |
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HU0000492A HUP0000492A3 (en) | 1996-11-22 | 1997-11-20 | N-(aryl/heteroarylacetyl) amino acid esters, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds |
Country Status (16)
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EP (1) | EP0951464B1 (hu) |
JP (1) | JP2001505204A (hu) |
KR (1) | KR20000069074A (hu) |
CN (1) | CN1237960A (hu) |
AT (1) | ATE295346T1 (hu) |
AU (1) | AU739035B2 (hu) |
BR (1) | BR9713404A (hu) |
CA (1) | CA2267065A1 (hu) |
DE (1) | DE69733272T2 (hu) |
HU (1) | HUP0000492A3 (hu) |
ID (1) | ID21956A (hu) |
IL (1) | IL129238A0 (hu) |
NO (1) | NO992463L (hu) |
NZ (1) | NZ334950A (hu) |
TR (1) | TR199901128T2 (hu) |
WO (1) | WO1998022430A1 (hu) |
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AU4707999A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
US6509331B1 (en) | 1998-06-22 | 2003-01-21 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
WO1999067220A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
US6552013B1 (en) | 1998-06-22 | 2003-04-22 | Elan Pharmaceuticals, Inc. | Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
WO1999066934A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS |
US6958330B1 (en) | 1998-06-22 | 2005-10-25 | Elan Pharmaceuticals, Inc. | Polycyclic α-amino-ε-caprolactams and related compounds |
NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
EP1131634A2 (en) | 1998-09-30 | 2001-09-12 | Elan Pharmaceuticals, Inc. | Determining the mechanism of beta-amyloid peptide generation |
WO2000038618A2 (en) | 1998-12-24 | 2000-07-06 | Du Pont Pharmaceuticals Company | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
EP1144388B1 (en) | 1999-01-22 | 2010-01-13 | Elan Pharmaceuticals, Inc. | Acyl derivatives which treat vla-4 related disorders |
US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
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WO2001060826A2 (en) | 2000-02-17 | 2001-08-23 | Bristol-Myers Squibb Pharma Company | SUCCINOYLAMINO CARBOCYCLES AND HETEROCYCLES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
MXPA02009729A (es) | 2000-04-03 | 2003-03-27 | Bristol Myers Squibb Pharma Co | Lactamas ciclicas como inhibidores de la produccion de la proteina a-beta. |
BR0107532A (pt) | 2000-04-03 | 2004-11-03 | Bristol Myers Squibb Pharma Co | Composto, uso do composto, método para o tratamento de disfunções neurológicas associadas com a produção de b-amilóide, método de inibição da atividade de y-secretase e composição farmacêutica |
AU2001257006A1 (en) | 2000-04-11 | 2001-10-23 | Du Pont Pharmaceuticals Company | Substituted lactams as inhibitors of abeta protein production |
US6878363B2 (en) | 2000-05-17 | 2005-04-12 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
BR0106717A (pt) | 2000-06-01 | 2002-04-16 | Bristol Myers Squibb Pharma Co | Compostos, composição farmacêutica e usos dos compostos de lactama inovadora |
US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
ATE524441T1 (de) * | 2000-12-28 | 2011-09-15 | Daiichi Seiyaku Co | Vla-4-inhibitoren |
ZA200304059B (en) * | 2000-12-28 | 2004-07-06 | Daiichi Seiyaku Co | VLA-4 inhibitors. |
EP1450795A1 (en) * | 2001-12-04 | 2004-09-01 | Elan Pharmaceuticals, Inc. | Peptide isosteres containing a heterocycle useful in the treatment of alzheimer's disease |
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FR2842523A1 (fr) * | 2002-07-17 | 2004-01-23 | Sanofi Synthelabo | Derives d'acylaminothiazole, leur preparation et leur application en therapeutique |
US7691894B2 (en) | 2003-07-24 | 2010-04-06 | Daiichi Pharmaceutical Co., Ltd. | Cyclohexanecarboxylic acid compound |
DE602006019296D1 (de) | 2005-09-29 | 2011-02-10 | Elan Pharm Inc | Pyrimidinylamidverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren |
CA2624524C (en) | 2005-09-29 | 2014-07-08 | Elan Pharmaceuticals, Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4 |
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IE33790B1 (en) * | 1968-06-04 | 1974-10-30 | Beecham Group Ltd | Derivatives of n-acylaminoacid amides |
CZ184194A3 (en) * | 1993-08-09 | 1995-03-15 | Lilly Co Eli | Aspartylprotease inhibitor and method of identifying thereof |
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1997
- 1997-11-20 AU AU52498/98A patent/AU739035B2/en not_active Ceased
- 1997-11-20 WO PCT/US1997/020355 patent/WO1998022430A1/en active IP Right Grant
- 1997-11-20 TR TR1999/01128T patent/TR199901128T2/xx unknown
- 1997-11-20 KR KR1019997004507A patent/KR20000069074A/ko not_active Application Discontinuation
- 1997-11-20 CA CA002267065A patent/CA2267065A1/en not_active Abandoned
- 1997-11-20 DE DE69733272T patent/DE69733272T2/de not_active Expired - Fee Related
- 1997-11-20 CN CN97199775A patent/CN1237960A/zh active Pending
- 1997-11-20 NZ NZ334950A patent/NZ334950A/en unknown
- 1997-11-20 JP JP52369998A patent/JP2001505204A/ja not_active Ceased
- 1997-11-20 HU HU0000492A patent/HUP0000492A3/hu unknown
- 1997-11-20 BR BR9713404-0A patent/BR9713404A/pt unknown
- 1997-11-20 AT AT97947410T patent/ATE295346T1/de not_active IP Right Cessation
- 1997-11-20 IL IL12923897A patent/IL129238A0/xx unknown
- 1997-11-20 ID IDW990269A patent/ID21956A/id unknown
- 1997-11-20 EP EP97947410A patent/EP0951464B1/en not_active Expired - Lifetime
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1999
- 1999-05-21 NO NO992463A patent/NO992463L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
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JP2001505204A (ja) | 2001-04-17 |
DE69733272D1 (de) | 2005-06-16 |
NZ334950A (en) | 2001-03-30 |
WO1998022430A1 (en) | 1998-05-28 |
ID21956A (id) | 1999-08-19 |
CN1237960A (zh) | 1999-12-08 |
IL129238A0 (en) | 2000-02-17 |
ATE295346T1 (de) | 2005-05-15 |
AU5249898A (en) | 1998-06-10 |
CA2267065A1 (en) | 1998-05-28 |
EP0951464B1 (en) | 2005-05-11 |
NO992463D0 (no) | 1999-05-21 |
AU739035B2 (en) | 2001-10-04 |
TR199901128T2 (xx) | 1999-07-21 |
DE69733272T2 (de) | 2006-01-26 |
EP0951464A1 (en) | 1999-10-27 |
NO992463L (no) | 1999-07-19 |
HUP0000492A3 (en) | 2000-06-28 |
KR20000069074A (ko) | 2000-11-25 |
BR9713404A (pt) | 2000-01-25 |
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