CY1108127T1 - Μεθοδοι για την προστασια αλλογενους μοσχευματος παγκρεατικων νησιδιων με χρηση διαλυτων μοριων μεταλλακτων ctla4 - Google Patents
Μεθοδοι για την προστασια αλλογενους μοσχευματος παγκρεατικων νησιδιων με χρηση διαλυτων μοριων μεταλλακτων ctla4Info
- Publication number
- CY1108127T1 CY1108127T1 CY20081100608T CY081100608T CY1108127T1 CY 1108127 T1 CY1108127 T1 CY 1108127T1 CY 20081100608 T CY20081100608 T CY 20081100608T CY 081100608 T CY081100608 T CY 081100608T CY 1108127 T1 CY1108127 T1 CY 1108127T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pancreatic islet
- protection
- methods
- mutant molecules
- soluble mutant
- Prior art date
Links
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 title abstract 3
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 title abstract 3
- 210000004153 islets of langerhan Anatomy 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 title 1
- 230000000735 allogeneic effect Effects 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P37/02—Immunomodulators
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Mycology (AREA)
- Rheumatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
Abstract
Η παρούσα εφεύρεση είναι μία μέθοδος αναστολής της απόρριψης μοσχεύματος κυττάρων παγκρεατικών νησιδίων ιδιαίτερα, για την θεραπευτική αντιμετώπιση του διαβήτη, όπως διαβήτη τύπου 1 και τύπου 2, με την χορήγηση σε ένα υποκείμενο μίας αποτελεσματικής ποσότητας από ένα δισλυτό μόριο μεταλλάκτη CTLA4. Ένα παράδειγμα διαλυτού μορίου μεταλλάκτη CTLA4 είναι L104EA29Yig.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29340201P | 2001-05-23 | 2001-05-23 | |
EP02734556A EP1397153B1 (en) | 2001-05-23 | 2002-05-23 | Methods for protecting allogeneic islet transplant using soluble ctla4 mutant molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108127T1 true CY1108127T1 (el) | 2014-02-12 |
Family
ID=23128937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100608T CY1108127T1 (el) | 2001-05-23 | 2008-06-09 | Μεθοδοι για την προστασια αλλογενους μοσχευματος παγκρεατικων νησιδιων με χρηση διαλυτων μοριων μεταλλακτων ctla4 |
Country Status (17)
Country | Link |
---|---|
US (2) | US7304033B2 (el) |
EP (1) | EP1397153B1 (el) |
JP (1) | JP4837880B2 (el) |
AT (1) | ATE390931T1 (el) |
AU (1) | AU2002305716B2 (el) |
CA (1) | CA2447921C (el) |
CY (1) | CY1108127T1 (el) |
CZ (1) | CZ305380B6 (el) |
DE (1) | DE60225914T2 (el) |
DK (1) | DK1397153T3 (el) |
ES (1) | ES2302811T3 (el) |
HU (1) | HU229680B1 (el) |
MX (1) | MXPA03010568A (el) |
NO (1) | NO332465B1 (el) |
PL (1) | PL204899B1 (el) |
PT (1) | PT1397153E (el) |
WO (1) | WO2002094202A2 (el) |
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CZ305380B6 (cs) | 2015-08-26 |
EP1397153A2 (en) | 2004-03-17 |
EP1397153B1 (en) | 2008-04-02 |
US20030022836A1 (en) | 2003-01-30 |
DE60225914T2 (de) | 2009-07-23 |
JP4837880B2 (ja) | 2011-12-14 |
WO2002094202B1 (en) | 2003-07-31 |
PL204899B1 (pl) | 2010-02-26 |
PT1397153E (pt) | 2008-06-12 |
DE60225914D1 (de) | 2008-05-15 |
US7304033B2 (en) | 2007-12-04 |
NO20035176L (no) | 2004-01-05 |
WO2002094202A3 (en) | 2003-06-26 |
AU2002305716B8 (en) | 2002-12-03 |
US20080160022A1 (en) | 2008-07-03 |
NO20035176D0 (no) | 2003-11-21 |
HUP0401590A3 (en) | 2012-09-28 |
EP1397153A4 (en) | 2006-01-04 |
ATE390931T1 (de) | 2008-04-15 |
NO332465B1 (no) | 2012-09-24 |
JP2004535402A (ja) | 2004-11-25 |
CA2447921A1 (en) | 2002-11-28 |
HUP0401590A2 (hu) | 2004-11-29 |
MXPA03010568A (es) | 2005-03-07 |
AU2002305716B2 (en) | 2007-10-25 |
US7829534B2 (en) | 2010-11-09 |
DK1397153T3 (da) | 2008-05-26 |
ES2302811T3 (es) | 2008-08-01 |
CA2447921C (en) | 2011-08-09 |
PL364578A1 (en) | 2004-12-13 |
CZ20033188A3 (cs) | 2005-04-13 |
WO2002094202A2 (en) | 2002-11-28 |
HU229680B1 (hu) | 2014-04-28 |
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