ATE429442T1 - Zusammensetzungen und verfahren zur wt1- spezifischen immuntherapie - Google Patents
Zusammensetzungen und verfahren zur wt1- spezifischen immuntherapieInfo
- Publication number
- ATE429442T1 ATE429442T1 AT02797061T AT02797061T ATE429442T1 AT E429442 T1 ATE429442 T1 AT E429442T1 AT 02797061 T AT02797061 T AT 02797061T AT 02797061 T AT02797061 T AT 02797061T AT E429442 T1 ATE429442 T1 AT E429442T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- polypeptide
- methods
- specific immunotherapy
- presenting
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000009169 immunotherapy Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/002,603 US7901693B2 (en) | 1998-09-30 | 2001-10-30 | Compositions and methods for WT1 specific immunotherapy |
| US10/125,635 US20030039635A1 (en) | 1998-09-30 | 2002-04-16 | Compositions and methods for WT1 specific immunotherapy |
| US10/195,835 US7655249B2 (en) | 1998-09-30 | 2002-07-12 | Compositions and methods for WT1 specific immunotherapy |
| US10/244,830 US20030235557A1 (en) | 1998-09-30 | 2002-09-16 | Compositions and methods for WT1 specific immunotherapy |
| PCT/US2002/035194 WO2003037060A2 (en) | 2001-10-30 | 2002-10-30 | Compositions and methods for wt1 specific immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429442T1 true ATE429442T1 (de) | 2009-05-15 |
Family
ID=27485189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02797061T ATE429442T1 (de) | 2001-10-30 | 2002-10-30 | Zusammensetzungen und verfahren zur wt1- spezifischen immuntherapie |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20030235557A1 (de) |
| EP (2) | EP2172476A3 (de) |
| JP (1) | JP4391232B2 (de) |
| KR (1) | KR100970854B1 (de) |
| CN (1) | CN100471868C (de) |
| AT (1) | ATE429442T1 (de) |
| AU (1) | AU2002361584B2 (de) |
| CA (1) | CA2465303C (de) |
| CY (1) | CY1111002T1 (de) |
| DE (1) | DE60232102D1 (de) |
| DK (1) | DK1468014T3 (de) |
| ES (1) | ES2326311T3 (de) |
| NZ (2) | NZ533220A (de) |
| WO (1) | WO2003037060A2 (de) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1103564E (pt) | 1998-07-31 | 2009-03-13 | Int Inst Cancer Immunology Inc | Antigénios de cancro com base no produto do gene supressor de tumor wt1 |
| US7329410B1 (en) | 1998-09-30 | 2008-02-12 | Corixa Corporation | Compositions and method for WT1 specific immunotherapy |
| US7901693B2 (en) | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7655249B2 (en) | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US20040097703A1 (en) * | 2001-03-22 | 2004-05-20 | Haruo Sugiyama | Wt1 modified peptide |
| US7553494B2 (en) | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
| KR101431312B1 (ko) | 2003-06-27 | 2014-08-20 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | Wt1 백신 적응 환자의 선택 방법 |
| BRPI0413334A (pt) * | 2003-09-05 | 2006-10-10 | Sanofi Pasteur Ltd | vetores de multiantìgenos para melanoma |
| PL2071028T3 (pl) | 2003-11-05 | 2012-06-29 | Int Inst Cancer Immunology Inc | Pochodzący z WT1 peptyd antygenowy wiążący się z HLA-DR |
| CA2548135C (en) * | 2003-12-01 | 2014-04-22 | Sloan-Kettering Institute For Cancer Research | Synthetic hla binding peptide analogues and uses thereof |
| EP1720565A1 (de) * | 2004-03-04 | 2006-11-15 | Corixa Corporation | Co-verkapselte wt1-polypeptid und immunstimulierende mikrokügelchen-formulierungen und verfahren dafür |
| EP2186896B1 (de) | 2004-03-31 | 2015-11-04 | International Institute of Cancer Immunology, Inc. | Von WT1 abgeleitete Krebs-Antigenpeptide |
| EP1657250A1 (de) * | 2004-11-11 | 2006-05-17 | Charité - Universitätsmedizin Berlin | HLA-A*01 bindendes T-Zell-Epitop von WT1 |
| EP2565201B1 (de) | 2005-10-17 | 2014-11-26 | Sloan-Kettering Institute For Cancer Research | WT1-HLA-Klasse II-bindende Peptide und Zusammensetzungen und Verfahren damit |
| DK2518149T3 (en) | 2006-02-22 | 2016-01-11 | Int Inst Cancer Immunology Inc | HLA-A * 3303-LIMITED WT1 PEPTIDE AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME |
| EP3117836A1 (de) | 2006-04-10 | 2017-01-18 | Sloan Kettering Institute For Cancer Research | Immunogene wt-1-peptide und verwendungen davon |
| CN100460013C (zh) * | 2006-09-05 | 2009-02-11 | 重庆康卫生物科技有限公司 | 口服重组幽门螺杆菌疫苗及其制备方法 |
| CN101573448B (zh) * | 2006-12-28 | 2012-07-11 | 株式会社癌免疫研究所 | Hla-a*1101限制的wt1肽及含有其的药物组合物 |
| AU2012227350C1 (en) * | 2006-12-28 | 2015-11-12 | International Institute Of Cancer Immunology, Inc. | HLA-A*1101-Restricted WT1 peptide and pharmaceutical composition comprising the same |
| ES2559062T3 (es) * | 2007-02-27 | 2016-02-10 | International Institute Of Cancer Immunology, Inc. | Método para la activación de linfocitos T colaboradores y composición para su uso en el método |
| KR101669279B1 (ko) | 2007-03-05 | 2016-10-26 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | 암 항원 특이적 t 세포의 수용체 유전자 및 그것에 따라 코드되는 펩티드 및 이들의 사용 |
| US20090035360A1 (en) * | 2007-05-24 | 2009-02-05 | Dominique Ingrid Lemoine | Lyophilised antigen composition |
| CN108117584B (zh) * | 2007-08-20 | 2021-08-24 | 肿瘤疗法科学股份有限公司 | Foxm1肽和包含foxm1肽的药剂 |
| EP2216041A4 (de) * | 2007-11-20 | 2012-10-24 | Nec Corp | Verfahren zur induktion einer zytotoxischen t-zelle, zytotoxischer t-zell-induktor und pharmazeutische zusammensetzung sowie impfstoff mit dem induktor |
| TWI469791B (zh) | 2009-02-18 | 2015-01-21 | Oncotherapy Science Inc | Foxm1胜肽以及含此胜肽之疫苗 |
| AR076349A1 (es) * | 2009-04-23 | 2011-06-01 | Int Inst Cancer Immunology Inc | Peptido auxiliar del antigeno del cancer |
| US8685656B2 (en) * | 2009-09-29 | 2014-04-01 | The Trustees Of The University Of Pennsylvania | Methods for diagnosing and treating encephalitis or epilepsy |
| AR083295A1 (es) | 2010-10-05 | 2013-02-13 | Univ Osaka | Metodo para activar celulas t auxiliares |
| CN102161998B (zh) * | 2011-01-14 | 2013-01-09 | 中国人民解放军军事医学科学院附属医院 | 基于b7-1-pe40kdel外毒素融合基因的dna疫苗及其用途 |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| CN103764826A (zh) | 2011-06-28 | 2014-04-30 | 株式会社癌免疫研究所 | 肽癌抗原-特异性t细胞的受体基因 |
| EP2757373A4 (de) | 2011-09-14 | 2015-07-01 | Int Inst Cancer Immunology Inc | Verfahren zur messung von anti-wt1-antikörpern |
| AU2013207669C1 (en) | 2012-01-13 | 2018-05-31 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| KR102877281B1 (ko) | 2012-12-13 | 2025-10-28 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Wt1 백신 |
| KR102158225B1 (ko) | 2012-12-17 | 2020-09-21 | 오츠카 세이야쿠 가부시키가이샤 | 헬퍼 t세포의 활성화 방법 |
| PT2945647T (pt) * | 2013-01-15 | 2020-11-26 | Memorial Sloan Kettering Cancer Center | Péptidos imunogénicos wt-1 e métodos de uso dos mesmos |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| JP6497691B2 (ja) * | 2013-02-05 | 2019-04-10 | 日東電工株式会社 | 粘膜投与用wt1ペプチド癌ワクチン組成物 |
| CN111781359A (zh) * | 2013-05-13 | 2020-10-16 | 株式会社癌免疫研究所 | 用于预测免疫疗法的临床效果的方法 |
| AU2014290288B2 (en) | 2013-07-15 | 2018-03-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-human papillomavirus 16 E6 T cell receptors |
| EP3112378B1 (de) * | 2014-02-26 | 2020-06-24 | Tella, Inc. | Wt1-antigenes polypeptid und antitumormittel mit besagtem polypeptid |
| US10682400B2 (en) | 2014-04-30 | 2020-06-16 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| CN116327902A (zh) | 2015-11-20 | 2023-06-27 | 纪念斯隆凯特林癌症中心 | 用于治疗癌症的方法和组合物 |
| CN105254760B (zh) * | 2015-11-21 | 2018-08-17 | 福州迈新生物技术开发有限公司 | 一株分泌抗wt1蛋白的单克隆抗体及其应用 |
| EP3411475B1 (de) | 2016-02-06 | 2025-08-27 | President and Fellows of Harvard College | Rekapitulation der hämatopoietischen nische zur wiederherstellung der immunität |
| CN115537372A (zh) | 2016-07-13 | 2022-12-30 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
| EP3493842A4 (de) | 2016-08-02 | 2020-07-29 | President and Fellows of Harvard College | Biomaterialien zur modulation von immunreaktionen |
| WO2018058002A1 (en) * | 2016-09-23 | 2018-03-29 | Fred Hutchinson Cancer Research Center | Tcrs specific for minor histocompatibility (h) antigen ha-1 and uses thereof |
| EP3549957A4 (de) | 2016-11-30 | 2020-08-05 | Sumitomo Dainippon Pharma Co., Ltd. | Wt1-helferpeptid und kombination des besagten peptids und eines krebsantigen-peptidkonjugats |
| US20210100886A1 (en) | 2017-03-30 | 2021-04-08 | Sumitomo Dainippon Pharma Co., Ltd. | Wt1 cancer antigen peptides and peptide conjugates comprising the peptides |
| WO2018227205A1 (en) * | 2017-06-09 | 2018-12-13 | President And Fellows Of Harvard College | Compositions for inducing an immune response |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| WO2020067453A1 (ja) | 2018-09-28 | 2020-04-02 | 大日本住友製薬株式会社 | 注射用組成物 |
| TW202200188A (zh) | 2020-05-12 | 2022-01-01 | 日商大日本住友製藥股份有限公司 | 用以處置癌症之醫藥組合物 |
| CN118076382A (zh) * | 2021-08-12 | 2024-05-24 | 株式会社癌免疫研究所 | 用于治疗或预防癌症的药用组合物和方法 |
| CN113730562B (zh) * | 2021-09-10 | 2024-06-04 | 中国人民解放军陆军军医大学 | 以壳聚糖修饰plga的wt1多肽纳米粒疫苗及其制备方法和应用 |
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2002
- 2002-09-16 US US10/244,830 patent/US20030235557A1/en not_active Abandoned
- 2002-10-30 NZ NZ533220A patent/NZ533220A/en not_active IP Right Cessation
- 2002-10-30 DE DE60232102T patent/DE60232102D1/de not_active Expired - Lifetime
- 2002-10-30 CN CNB028264924A patent/CN100471868C/zh not_active Expired - Fee Related
- 2002-10-30 NZ NZ560858A patent/NZ560858A/en not_active IP Right Cessation
- 2002-10-30 AT AT02797061T patent/ATE429442T1/de active
- 2002-10-30 EP EP09153790A patent/EP2172476A3/de not_active Withdrawn
- 2002-10-30 CA CA2465303A patent/CA2465303C/en not_active Expired - Fee Related
- 2002-10-30 WO PCT/US2002/035194 patent/WO2003037060A2/en not_active Ceased
- 2002-10-30 ES ES02797061T patent/ES2326311T3/es not_active Expired - Lifetime
- 2002-10-30 EP EP02797061A patent/EP1468014B1/de not_active Expired - Lifetime
- 2002-10-30 DK DK02797061T patent/DK1468014T3/da active
- 2002-10-30 AU AU2002361584A patent/AU2002361584B2/en not_active Ceased
- 2002-10-30 JP JP2003539419A patent/JP4391232B2/ja not_active Expired - Fee Related
- 2002-10-30 KR KR1020047006659A patent/KR100970854B1/ko not_active Expired - Fee Related
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2009
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2002361584B2 (en) | 2009-07-23 |
| CN1671733A (zh) | 2005-09-21 |
| CN100471868C (zh) | 2009-03-25 |
| EP1468014A2 (de) | 2004-10-20 |
| JP2005518192A (ja) | 2005-06-23 |
| ES2326311T3 (es) | 2009-10-07 |
| KR100970854B1 (ko) | 2010-07-20 |
| CA2465303A1 (en) | 2003-05-08 |
| NZ560858A (en) | 2009-06-26 |
| EP2172476A3 (de) | 2010-06-23 |
| DK1468014T3 (da) | 2009-08-10 |
| NZ533220A (en) | 2008-04-30 |
| JP4391232B2 (ja) | 2009-12-24 |
| EP1468014B1 (de) | 2009-04-22 |
| WO2003037060A2 (en) | 2003-05-08 |
| CY1111002T1 (el) | 2015-06-11 |
| DE60232102D1 (de) | 2009-06-04 |
| CA2465303C (en) | 2011-09-13 |
| EP1468014A4 (de) | 2006-05-17 |
| EP2172476A2 (de) | 2010-04-07 |
| US20030235557A1 (en) | 2003-12-25 |
| WO2003037060A3 (en) | 2004-08-12 |
| KR20050042226A (ko) | 2005-05-06 |
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