ATE429442T1 - Zusammensetzungen und verfahren zur wt1- spezifischen immuntherapie - Google Patents
Zusammensetzungen und verfahren zur wt1- spezifischen immuntherapieInfo
- Publication number
- ATE429442T1 ATE429442T1 AT02797061T AT02797061T ATE429442T1 AT E429442 T1 ATE429442 T1 AT E429442T1 AT 02797061 T AT02797061 T AT 02797061T AT 02797061 T AT02797061 T AT 02797061T AT E429442 T1 ATE429442 T1 AT E429442T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- polypeptide
- methods
- specific immunotherapy
- presenting
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000009169 immunotherapy Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/002,603 US7901693B2 (en) | 1998-09-30 | 2001-10-30 | Compositions and methods for WT1 specific immunotherapy |
| US10/125,635 US20030039635A1 (en) | 1998-09-30 | 2002-04-16 | Compositions and methods for WT1 specific immunotherapy |
| US10/195,835 US7655249B2 (en) | 1998-09-30 | 2002-07-12 | Compositions and methods for WT1 specific immunotherapy |
| US10/244,830 US20030235557A1 (en) | 1998-09-30 | 2002-09-16 | Compositions and methods for WT1 specific immunotherapy |
| PCT/US2002/035194 WO2003037060A2 (en) | 2001-10-30 | 2002-10-30 | Compositions and methods for wt1 specific immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429442T1 true ATE429442T1 (de) | 2009-05-15 |
Family
ID=27485189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02797061T ATE429442T1 (de) | 2001-10-30 | 2002-10-30 | Zusammensetzungen und verfahren zur wt1- spezifischen immuntherapie |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20030235557A1 (de) |
| EP (2) | EP2172476A3 (de) |
| JP (1) | JP4391232B2 (de) |
| KR (1) | KR100970854B1 (de) |
| CN (1) | CN100471868C (de) |
| AT (1) | ATE429442T1 (de) |
| AU (1) | AU2002361584B2 (de) |
| CA (1) | CA2465303C (de) |
| CY (1) | CY1111002T1 (de) |
| DE (1) | DE60232102D1 (de) |
| DK (1) | DK1468014T3 (de) |
| ES (1) | ES2326311T3 (de) |
| NZ (2) | NZ560858A (de) |
| WO (1) | WO2003037060A2 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1103564B1 (de) | 1998-07-31 | 2009-01-07 | International Institute of Cancer Immunology, Inc. | Krebsantigene, basierend auf dem tumorunterdrückenden genprodukt wt1 |
| US7901693B2 (en) | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7329410B1 (en) | 1998-09-30 | 2008-02-12 | Corixa Corporation | Compositions and method for WT1 specific immunotherapy |
| US7655249B2 (en) | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| BRPI0208183B8 (pt) * | 2001-03-22 | 2021-05-25 | Sugiyama Haruo | peptídeo antígeno de câncer modificado por wt1 e vacinas para câncer |
| US7553494B2 (en) | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
| ES2443582T3 (es) * | 2003-06-27 | 2014-02-19 | International Institute Of Cancer Immunology, Inc. | Método para diagnosticar el cáncer que comprende la medición de las células precursoras de CTL específicos de WT1 |
| KR101141951B1 (ko) * | 2003-09-05 | 2012-05-04 | 테리온 바이오로직스, 인크. | 흑색종용 다중-항원 벡터 |
| CN101580538B (zh) | 2003-11-05 | 2013-06-19 | 株式会社国际癌症免疫研究所 | Wt1衍生的hla-dr-结合抗原肽 |
| US7488718B2 (en) * | 2003-12-01 | 2009-02-10 | Sloan Kettering Institue For Cancer Research | Synthetic HLA binding peptide analogues and uses thereof |
| US20050260217A1 (en) * | 2004-03-04 | 2005-11-24 | Corixa Corporation | Co-encapsulated WT1 polypeptide and immunostimulant microsphere formulations and methods thereof |
| ES2556232T3 (es) | 2004-03-31 | 2016-01-14 | International Institute Of Cancer Immunology, Inc. | Péptidos antigénicos del cáncer derivados de WT1 |
| EP1657250A1 (de) * | 2004-11-11 | 2006-05-17 | Charité - Universitätsmedizin Berlin | HLA-A*01 bindendes T-Zell-Epitop von WT1 |
| WO2007047764A2 (en) * | 2005-10-17 | 2007-04-26 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| PL1988163T3 (pl) | 2006-02-22 | 2012-11-30 | Int Inst Cancer Immunology Inc | Ograniczony do hla-a*3303 peptyd wt1 i zawierająca go kompozycja farmaceutyczna |
| EP3117836A1 (de) | 2006-04-10 | 2017-01-18 | Sloan Kettering Institute For Cancer Research | Immunogene wt-1-peptide und verwendungen davon |
| CN100460013C (zh) * | 2006-09-05 | 2009-02-11 | 重庆康卫生物科技有限公司 | 口服重组幽门螺杆菌疫苗及其制备方法 |
| AU2012227350C1 (en) * | 2006-12-28 | 2015-11-12 | International Institute Of Cancer Immunology, Inc. | HLA-A*1101-Restricted WT1 peptide and pharmaceutical composition comprising the same |
| NZ601175A (en) | 2006-12-28 | 2012-12-21 | Int Inst Cancer Immunology Inc | Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same |
| BRPI0808084A2 (pt) | 2007-02-27 | 2014-07-22 | Int Inst Cancer Immunology Inc | Método para ativação de células t auxiliadoras e composição para uso no método. |
| WO2008108257A1 (ja) | 2007-03-05 | 2008-09-12 | International Institute Of Cancer Immunology, Inc. | 癌抗原特異的t細胞のレセプター遺伝子およびそれによりコードされるペプチドならびにそれらの使用 |
| CA2687632C (en) * | 2007-05-24 | 2013-01-15 | Glaxosmithkline Biologicals S.A. | Lyophilised antigen composition |
| JP5555952B2 (ja) * | 2007-08-20 | 2014-07-23 | オンコセラピー・サイエンス株式会社 | Foxm1ペプチドおよびこれを含む薬剤 |
| JPWO2009066462A1 (ja) * | 2007-11-20 | 2011-04-07 | 日本電気株式会社 | 細胞傷害性t細胞の誘導方法、細胞傷害性t細胞の誘導剤、およびそれを用いた医薬組成物およびワクチン |
| TWI469791B (zh) | 2009-02-18 | 2015-01-21 | Oncotherapy Science Inc | Foxm1胜肽以及含此胜肽之疫苗 |
| AR076349A1 (es) | 2009-04-23 | 2011-06-01 | Int Inst Cancer Immunology Inc | Peptido auxiliar del antigeno del cancer |
| DK2483417T3 (en) * | 2009-09-29 | 2017-05-15 | Univ Pennsylvania | PROCEDURES FOR DIAGNOSTICATION AND TREATMENT OF ENCEPHALITIS OR EPILEPSY |
| EP2626418B8 (de) | 2010-10-05 | 2021-03-24 | International Institute of Cancer Immunology, Inc. | Verfahren zur aktivierung von t-helferzellen |
| CN102161998B (zh) * | 2011-01-14 | 2013-01-09 | 中国人民解放军军事医学科学院附属医院 | 基于b7-1-pe40kdel外毒素融合基因的dna疫苗及其用途 |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| CN103764826A (zh) | 2011-06-28 | 2014-04-30 | 株式会社癌免疫研究所 | 肽癌抗原-特异性t细胞的受体基因 |
| AU2012309417B2 (en) * | 2011-09-14 | 2017-09-14 | International Institute Of Cancer Immunology, Inc. | Method for measuring anti-WT1 antibody |
| HK1204261A1 (en) | 2012-01-13 | 2015-11-13 | Memorial Sloan Kettering Cancer Center | Immunogenic wt-1 peptides and methods of use thereof |
| CN104812401B (zh) * | 2012-12-13 | 2017-10-13 | 宾夕法尼亚大学理事会 | Wt1疫苗 |
| CA2892660C (en) | 2012-12-17 | 2022-02-15 | Otsuka Pharmaceutical Co., Ltd. | Method for activating helper t cell |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| PT2945647T (pt) * | 2013-01-15 | 2020-11-26 | Memorial Sloan Kettering Cancer Center | Péptidos imunogénicos wt-1 e métodos de uso dos mesmos |
| CN103961702B (zh) * | 2013-02-05 | 2019-04-09 | 日东电工株式会社 | 粘膜给予用wt1肽癌症疫苗组合物 |
| WO2014185387A1 (ja) * | 2013-05-13 | 2014-11-20 | 株式会社癌免疫研究所 | 免疫療法の臨床効果の予測法 |
| AU2014290288B2 (en) * | 2013-07-15 | 2018-03-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-human papillomavirus 16 E6 T cell receptors |
| KR101804343B1 (ko) * | 2014-02-26 | 2017-12-04 | 텔라 가부시키가이샤 | Wt1 항원성 폴리펩티드 및 상기 폴리펩티드를 포함하는 항종양제 |
| JP7348708B2 (ja) | 2014-04-30 | 2023-09-21 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 組み合わせワクチン装置および癌細胞を殺滅する方法 |
| EP4130026A1 (de) | 2015-11-20 | 2023-02-08 | Memorial Sloan-Kettering Cancer Center | Verfahren und zusammensetzungen zum behandeln von krebs |
| CN105254760B (zh) * | 2015-11-21 | 2018-08-17 | 福州迈新生物技术开发有限公司 | 一株分泌抗wt1蛋白的单克隆抗体及其应用 |
| JP7138864B2 (ja) | 2016-02-06 | 2022-09-20 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫を再構成するための造血ニッチの再現 |
| JP2019522486A (ja) | 2016-07-13 | 2019-08-15 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 抗原提示細胞模倣足場およびそれを作製および使用するための方法 |
| CA3032505A1 (en) | 2016-08-02 | 2018-02-08 | President And Fellows Of Harvard College | Biomaterials for modulating immune responses |
| EP3516044B1 (de) * | 2016-09-23 | 2025-04-16 | Fred Hutchinson Cancer Center | Tcrs spezifisch für neben-histokompatibilitäts (h)-antigen ha-1 und verwendungen davon |
| WO2018101309A1 (ja) | 2016-11-30 | 2018-06-07 | 大日本住友製薬株式会社 | Wt1ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ |
| JPWO2018181648A1 (ja) | 2017-03-30 | 2020-02-13 | 大日本住友製薬株式会社 | Wt1癌抗原ペプチドおよびこれを含むペプチドコンジュゲート体 |
| WO2018227205A1 (en) * | 2017-06-09 | 2018-12-13 | President And Fellows Of Harvard College | Compositions for inducing an immune response |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| EP3858377A4 (de) | 2018-09-28 | 2022-11-30 | Sumitomo Pharma Co., Ltd. | Injizierbare zusammensetzung |
| WO2021061837A1 (en) | 2019-09-23 | 2021-04-01 | President And Fellows Of Harvard College | Biomaterial-based antigen free vaccine and the use thereof |
| WO2021230247A1 (ja) | 2020-05-12 | 2021-11-18 | 大日本住友製薬株式会社 | 癌を処置するための医薬組成物 |
| JPWO2023017836A1 (de) * | 2021-08-12 | 2023-02-16 | ||
| CN113730562B (zh) * | 2021-09-10 | 2024-06-04 | 中国人民解放军陆军军医大学 | 以壳聚糖修饰plga的wt1多肽纳米粒疫苗及其制备方法和应用 |
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2002
- 2002-09-16 US US10/244,830 patent/US20030235557A1/en not_active Abandoned
- 2002-10-30 EP EP09153790A patent/EP2172476A3/de not_active Withdrawn
- 2002-10-30 DE DE60232102T patent/DE60232102D1/de not_active Expired - Lifetime
- 2002-10-30 NZ NZ560858A patent/NZ560858A/en not_active IP Right Cessation
- 2002-10-30 EP EP02797061A patent/EP1468014B1/de not_active Expired - Lifetime
- 2002-10-30 AT AT02797061T patent/ATE429442T1/de active
- 2002-10-30 ES ES02797061T patent/ES2326311T3/es not_active Expired - Lifetime
- 2002-10-30 AU AU2002361584A patent/AU2002361584B2/en not_active Ceased
- 2002-10-30 WO PCT/US2002/035194 patent/WO2003037060A2/en not_active Ceased
- 2002-10-30 DK DK02797061T patent/DK1468014T3/da active
- 2002-10-30 KR KR1020047006659A patent/KR100970854B1/ko not_active Expired - Fee Related
- 2002-10-30 CN CNB028264924A patent/CN100471868C/zh not_active Expired - Fee Related
- 2002-10-30 NZ NZ533220A patent/NZ533220A/en not_active IP Right Cessation
- 2002-10-30 CA CA2465303A patent/CA2465303C/en not_active Expired - Fee Related
- 2002-10-30 JP JP2003539419A patent/JP4391232B2/ja not_active Expired - Fee Related
-
2009
- 2009-07-22 CY CY20091100785T patent/CY1111002T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100970854B1 (ko) | 2010-07-20 |
| EP2172476A3 (de) | 2010-06-23 |
| DE60232102D1 (de) | 2009-06-04 |
| AU2002361584B2 (en) | 2009-07-23 |
| JP4391232B2 (ja) | 2009-12-24 |
| CA2465303C (en) | 2011-09-13 |
| DK1468014T3 (da) | 2009-08-10 |
| CA2465303A1 (en) | 2003-05-08 |
| US20030235557A1 (en) | 2003-12-25 |
| EP1468014A4 (de) | 2006-05-17 |
| WO2003037060A2 (en) | 2003-05-08 |
| EP2172476A2 (de) | 2010-04-07 |
| NZ560858A (en) | 2009-06-26 |
| NZ533220A (en) | 2008-04-30 |
| KR20050042226A (ko) | 2005-05-06 |
| EP1468014A2 (de) | 2004-10-20 |
| CY1111002T1 (el) | 2015-06-11 |
| CN1671733A (zh) | 2005-09-21 |
| CN100471868C (zh) | 2009-03-25 |
| ES2326311T3 (es) | 2009-10-07 |
| JP2005518192A (ja) | 2005-06-23 |
| EP1468014B1 (de) | 2009-04-22 |
| WO2003037060A3 (en) | 2004-08-12 |
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