ATE429442T1 - Zusammensetzungen und verfahren zur wt1- spezifischen immuntherapie - Google Patents
Zusammensetzungen und verfahren zur wt1- spezifischen immuntherapieInfo
- Publication number
- ATE429442T1 ATE429442T1 AT02797061T AT02797061T ATE429442T1 AT E429442 T1 ATE429442 T1 AT E429442T1 AT 02797061 T AT02797061 T AT 02797061T AT 02797061 T AT02797061 T AT 02797061T AT E429442 T1 ATE429442 T1 AT E429442T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- polypeptide
- methods
- specific immunotherapy
- presenting
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000009169 immunotherapy Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/002,603 US7901693B2 (en) | 1998-09-30 | 2001-10-30 | Compositions and methods for WT1 specific immunotherapy |
| US10/125,635 US20030039635A1 (en) | 1998-09-30 | 2002-04-16 | Compositions and methods for WT1 specific immunotherapy |
| US10/195,835 US7655249B2 (en) | 1998-09-30 | 2002-07-12 | Compositions and methods for WT1 specific immunotherapy |
| US10/244,830 US20030235557A1 (en) | 1998-09-30 | 2002-09-16 | Compositions and methods for WT1 specific immunotherapy |
| PCT/US2002/035194 WO2003037060A2 (en) | 2001-10-30 | 2002-10-30 | Compositions and methods for wt1 specific immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429442T1 true ATE429442T1 (de) | 2009-05-15 |
Family
ID=27485189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02797061T ATE429442T1 (de) | 2001-10-30 | 2002-10-30 | Zusammensetzungen und verfahren zur wt1- spezifischen immuntherapie |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20030235557A1 (de) |
| EP (2) | EP2172476A3 (de) |
| JP (1) | JP4391232B2 (de) |
| KR (1) | KR100970854B1 (de) |
| CN (1) | CN100471868C (de) |
| AT (1) | ATE429442T1 (de) |
| AU (1) | AU2002361584B2 (de) |
| CA (1) | CA2465303C (de) |
| CY (1) | CY1111002T1 (de) |
| DE (1) | DE60232102D1 (de) |
| DK (1) | DK1468014T3 (de) |
| ES (1) | ES2326311T3 (de) |
| NZ (2) | NZ560858A (de) |
| WO (1) | WO2003037060A2 (de) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100560130C (zh) | 1998-07-31 | 2009-11-18 | 株式会社国际癌症免疫研究所 | 基于癌抑制基因wt1的产物的癌抗原 |
| US7329410B1 (en) | 1998-09-30 | 2008-02-12 | Corixa Corporation | Compositions and method for WT1 specific immunotherapy |
| US7655249B2 (en) | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7901693B2 (en) | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| EP1371664B1 (de) * | 2001-03-22 | 2008-01-09 | International Institute of Cancer Immunology, Inc. | Wti-modifiziertes peptid |
| US7553494B2 (en) | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
| EP2338509B1 (de) * | 2003-06-27 | 2014-06-18 | International Institute of Cancer Immunology, Inc. | Verfahren zur Auswahl von für den WT1-Impfstoff geeigneten Patienten |
| BRPI0413334A (pt) * | 2003-09-05 | 2006-10-10 | Sanofi Pasteur Ltd | vetores de multiantìgenos para melanoma |
| KR101522079B1 (ko) | 2003-11-05 | 2015-05-21 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | Wt1 유래의 hla-dr 결합성 항원 펩티드 |
| EP2478913A1 (de) * | 2003-12-01 | 2012-07-25 | Sloan-Kettering Institute For Cancer Research | Synthetische HLA-bindende Peptidanaloga und Verwendungen dafür |
| EP1720565A1 (de) * | 2004-03-04 | 2006-11-15 | Corixa Corporation | Co-verkapselte wt1-polypeptid und immunstimulierende mikrokügelchen-formulierungen und verfahren dafür |
| WO2005095598A1 (ja) * | 2004-03-31 | 2005-10-13 | International Institute Of Cancer Immunology, Inc. | Wt1由来の癌抗原ペプチド |
| EP1657250A1 (de) * | 2004-11-11 | 2006-05-17 | Charité - Universitätsmedizin Berlin | HLA-A*01 bindendes T-Zell-Epitop von WT1 |
| US8765687B2 (en) * | 2005-10-17 | 2014-07-01 | Sloan Kettering Institute For Cancer Research | WT1 HLA class II-binding peptides and compositions and methods comprising same |
| WO2007097358A1 (ja) | 2006-02-22 | 2007-08-30 | International Institute Of Cancer Immunology, Inc. | Hla-a*3303拘束性wt1ペプチド、およびそれを含む医薬組成物 |
| EP3117836A1 (de) | 2006-04-10 | 2017-01-18 | Sloan Kettering Institute For Cancer Research | Immunogene wt-1-peptide und verwendungen davon |
| CN100460013C (zh) * | 2006-09-05 | 2009-02-11 | 重庆康卫生物科技有限公司 | 口服重组幽门螺杆菌疫苗及其制备方法 |
| CN102302788B (zh) * | 2006-12-28 | 2016-06-15 | 株式会社癌免疫研究所 | Hla-a*1101限制的wt1肽及含有其的药物组合物 |
| AU2012227350C1 (en) * | 2006-12-28 | 2015-11-12 | International Institute Of Cancer Immunology, Inc. | HLA-A*1101-Restricted WT1 peptide and pharmaceutical composition comprising the same |
| PL2119778T3 (pl) | 2007-02-27 | 2016-04-29 | Int Inst Cancer Immunology Inc | Sposób aktywacji pomocniczej komórki T oraz kompozycja do zastosowania w tym sposobie |
| EP3492590A3 (de) | 2007-03-05 | 2019-06-19 | International Institute of Cancer Immunology, Inc. | Krebs-antigen-spezifisches t-zell-rezeptorgen, durch das gen codiertes peptid und verwendung davon |
| TW200911304A (en) * | 2007-05-24 | 2009-03-16 | Glaxosmithkline Biolog Sa | Lyophillised antigen composition |
| EP3263585B1 (de) | 2007-08-20 | 2022-01-19 | Oncotherapy Science, Inc. | Foxm1-peptid und arzneimittel damit |
| JPWO2009066462A1 (ja) * | 2007-11-20 | 2011-04-07 | 日本電気株式会社 | 細胞傷害性t細胞の誘導方法、細胞傷害性t細胞の誘導剤、およびそれを用いた医薬組成物およびワクチン |
| TWI469791B (zh) | 2009-02-18 | 2015-01-21 | Oncotherapy Science Inc | Foxm1胜肽以及含此胜肽之疫苗 |
| AR076349A1 (es) * | 2009-04-23 | 2011-06-01 | Int Inst Cancer Immunology Inc | Peptido auxiliar del antigeno del cancer |
| CN102803502B (zh) * | 2009-09-29 | 2019-06-04 | 宾夕法尼亚大学理事会 | 用于诊断和治疗脑炎或癫痫的方法 |
| CN103298928B (zh) | 2010-10-05 | 2016-04-20 | 株式会社癌免疫研究所 | 用于激活辅助性t细胞的方法 |
| CN102161998B (zh) * | 2011-01-14 | 2013-01-09 | 中国人民解放军军事医学科学院附属医院 | 基于b7-1-pe40kdel外毒素融合基因的dna疫苗及其用途 |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| EP3447140A3 (de) | 2011-06-28 | 2019-05-29 | International Institute of Cancer Immunology, Inc. | Rezeptorgen für peptid-krebs-antigenspezifische t-zellen |
| CN103797369B (zh) * | 2011-09-14 | 2017-09-19 | 株式会社癌免疫研究所 | 抗wt1抗体的测定方法 |
| CA2861206C (en) | 2012-01-13 | 2021-07-06 | Richard J. O'reilly | Immunogenic wt-1 peptides and methods of use thereof |
| EP3782640A1 (de) * | 2012-12-13 | 2021-02-24 | The Trustees Of The University Of Pennsylvania | Wt1-impfstoff |
| CN104995203B (zh) | 2012-12-17 | 2019-06-28 | 大塚制药株式会社 | 辅助性t细胞的活化方法 |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| PL2945647T3 (pl) * | 2013-01-15 | 2021-03-08 | Memorial Sloan Kettering Cancer Center | Immunogenne peptydy wt-1 i sposoby ich zastosowania |
| RU2687026C2 (ru) * | 2013-02-05 | 2019-05-06 | Нитто Денко Корпорейшн | Вакцинная композиция против злокачественной опухоли на основе пептида wt1 для мукозального введения |
| WO2014185387A1 (ja) * | 2013-05-13 | 2014-11-20 | 株式会社癌免疫研究所 | 免疫療法の臨床効果の予測法 |
| ES2745472T3 (es) * | 2013-07-15 | 2020-03-02 | The U S A As Represented By The Secretary Department Of Health And Human Services Office Of Tech Tra | Receptores de células T anti-virus del papiloma humano 16 E6 |
| WO2015129790A1 (ja) * | 2014-02-26 | 2015-09-03 | 株式会社バイオイミュランス | Wt1抗原性ポリペプチド、及び該ポリペプチドを含む抗腫瘍剤 |
| CN107073090A (zh) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | 结合的疫苗装置和杀死癌细胞的方法 |
| MA43283B1 (fr) | 2015-11-20 | 2022-08-31 | Memorial Sloan Kettering Cancer Center | Composition pour le traitement du cancer |
| CN105254760B (zh) * | 2015-11-21 | 2018-08-17 | 福州迈新生物技术开发有限公司 | 一株分泌抗wt1蛋白的单克隆抗体及其应用 |
| CN115487351A (zh) | 2016-02-06 | 2022-12-20 | 哈佛学院校长同事会 | 重塑造血巢以重建免疫 |
| JP2019522486A (ja) | 2016-07-13 | 2019-08-15 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 抗原提示細胞模倣足場およびそれを作製および使用するための方法 |
| AU2017305345B2 (en) | 2016-08-02 | 2024-09-05 | President And Fellows Of Harvard College | Biomaterials for modulating immune responses |
| AU2017331362B2 (en) * | 2016-09-23 | 2025-01-23 | Fred Hutchinson Cancer Center | TCRs specific for minor histocompatibility (H) antigen HA-1 and uses thereof |
| JP7209963B2 (ja) | 2016-11-30 | 2023-01-23 | 住友ファーマ株式会社 | Wt1ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ |
| US20210100886A1 (en) | 2017-03-30 | 2021-04-08 | Sumitomo Dainippon Pharma Co., Ltd. | Wt1 cancer antigen peptides and peptide conjugates comprising the peptides |
| WO2018227205A1 (en) * | 2017-06-09 | 2018-12-13 | President And Fellows Of Harvard College | Compositions for inducing an immune response |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| KR20210068060A (ko) | 2018-09-28 | 2021-06-08 | 다이니뽄 스미토모 세이야쿠 가부시키가이샤 | 주사용 조성물 |
| WO2021061837A1 (en) | 2019-09-23 | 2021-04-01 | President And Fellows Of Harvard College | Biomaterial-based antigen free vaccine and the use thereof |
| TW202200188A (zh) | 2020-05-12 | 2022-01-01 | 日商大日本住友製藥股份有限公司 | 用以處置癌症之醫藥組合物 |
| KR20240046880A (ko) * | 2021-08-12 | 2024-04-11 | 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 | 암을 처치 또는 예방하기 위한 의약 조성물 및 방법 |
| CN113730562B (zh) * | 2021-09-10 | 2024-06-04 | 中国人民解放军陆军军医大学 | 以壳聚糖修饰plga的wt1多肽纳米粒疫苗及其制备方法和应用 |
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2002
- 2002-09-16 US US10/244,830 patent/US20030235557A1/en not_active Abandoned
- 2002-10-30 AT AT02797061T patent/ATE429442T1/de active
- 2002-10-30 CN CNB028264924A patent/CN100471868C/zh not_active Expired - Fee Related
- 2002-10-30 KR KR1020047006659A patent/KR100970854B1/ko not_active Expired - Fee Related
- 2002-10-30 NZ NZ560858A patent/NZ560858A/en not_active IP Right Cessation
- 2002-10-30 AU AU2002361584A patent/AU2002361584B2/en not_active Ceased
- 2002-10-30 EP EP09153790A patent/EP2172476A3/de not_active Withdrawn
- 2002-10-30 ES ES02797061T patent/ES2326311T3/es not_active Expired - Lifetime
- 2002-10-30 EP EP02797061A patent/EP1468014B1/de not_active Expired - Lifetime
- 2002-10-30 JP JP2003539419A patent/JP4391232B2/ja not_active Expired - Fee Related
- 2002-10-30 DE DE60232102T patent/DE60232102D1/de not_active Expired - Lifetime
- 2002-10-30 CA CA2465303A patent/CA2465303C/en not_active Expired - Fee Related
- 2002-10-30 DK DK02797061T patent/DK1468014T3/da active
- 2002-10-30 NZ NZ533220A patent/NZ533220A/en not_active IP Right Cessation
- 2002-10-30 WO PCT/US2002/035194 patent/WO2003037060A2/en not_active Ceased
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2009
- 2009-07-22 CY CY20091100785T patent/CY1111002T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1468014T3 (da) | 2009-08-10 |
| CA2465303C (en) | 2011-09-13 |
| NZ560858A (en) | 2009-06-26 |
| EP2172476A2 (de) | 2010-04-07 |
| EP1468014A4 (de) | 2006-05-17 |
| CY1111002T1 (el) | 2015-06-11 |
| CN1671733A (zh) | 2005-09-21 |
| KR20050042226A (ko) | 2005-05-06 |
| ES2326311T3 (es) | 2009-10-07 |
| JP2005518192A (ja) | 2005-06-23 |
| CA2465303A1 (en) | 2003-05-08 |
| WO2003037060A2 (en) | 2003-05-08 |
| NZ533220A (en) | 2008-04-30 |
| AU2002361584B2 (en) | 2009-07-23 |
| US20030235557A1 (en) | 2003-12-25 |
| WO2003037060A3 (en) | 2004-08-12 |
| JP4391232B2 (ja) | 2009-12-24 |
| EP2172476A3 (de) | 2010-06-23 |
| DE60232102D1 (de) | 2009-06-04 |
| CN100471868C (zh) | 2009-03-25 |
| EP1468014B1 (de) | 2009-04-22 |
| KR100970854B1 (ko) | 2010-07-20 |
| EP1468014A2 (de) | 2004-10-20 |
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