EA200800268A1 - КОМБИНИРОВАННАЯ ТЕРАПИЯ АНТИТЕЛОМ ПРОТИВ CTLA-4 И СОДЕРЖАЩИМ CpG-МОТИВ СИНТЕТИЧЕСКИМ ОЛИГОДЕЗОКСИНУКЛЕОТИДОМ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ - Google Patents

КОМБИНИРОВАННАЯ ТЕРАПИЯ АНТИТЕЛОМ ПРОТИВ CTLA-4 И СОДЕРЖАЩИМ CpG-МОТИВ СИНТЕТИЧЕСКИМ ОЛИГОДЕЗОКСИНУКЛЕОТИДОМ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ

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Publication number
EA200800268A1
EA200800268A1 EA200800268A EA200800268A EA200800268A1 EA 200800268 A1 EA200800268 A1 EA 200800268A1 EA 200800268 A EA200800268 A EA 200800268A EA 200800268 A EA200800268 A EA 200800268A EA 200800268 A1 EA200800268 A1 EA 200800268A1
Authority
EA
Eurasian Patent Office
Prior art keywords
against ctla
treatment
malignant tumor
cpg
olygesoxynecletoside
Prior art date
Application number
EA200800268A
Other languages
English (en)
Inventor
Дэвид Роберт Джон Ридетт
Ярль Ульф Биргер Юнгнелиус
Хесус Гомес-Новарро
Дуглас С. Хансон
Артур М. Криг
Original Assignee
Коли Фармасьютикал Груп, Инк.
Пфайзер Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Коли Фармасьютикал Груп, Инк., Пфайзер Инк. filed Critical Коли Фармасьютикал Груп, Инк.
Publication of EA200800268A1 publication Critical patent/EA200800268A1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Изобретение относится к введению антитела против CTLA-4, в частности антител человека против CTLA-4, таких как антитела, имеющие аминокислотные последовательности антител 3.1.1, 4.1.1, 4.8.1, 4.10.2, 4.13.1, 4.14.3, 6.1.1, 11.2.1, 11.6.1, 11.7.1, 12.3.1.1, 12.9.1.1 и MDX-010, в сочетании с иммуностимулирующим нуклеотидом, т.е. CpG ODN PF3512676, для лечения злокачественной опухоли. Изобретение относится к введению сочетания антитела против CTLA-4 и CpG ODN PF3512676 в качестве неоадъювантной, адъювантной терапии, терапии первой линии, терапии второй линии и терапии третьей линии злокачественной опухоли, как локализованной, так и метастазирующей, и в любой момент(ы) времени на протяжении заболевания (т.е. на любой стадии злокачественной опухоли).
EA200800268A 2005-07-07 2006-06-30 КОМБИНИРОВАННАЯ ТЕРАПИЯ АНТИТЕЛОМ ПРОТИВ CTLA-4 И СОДЕРЖАЩИМ CpG-МОТИВ СИНТЕТИЧЕСКИМ ОЛИГОДЕЗОКСИНУКЛЕОТИДОМ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ EA200800268A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69708205P 2005-07-07 2005-07-07
PCT/US2006/025711 WO2007008463A2 (en) 2005-07-07 2006-06-30 Anti-ctla-4 antibody and cpg-motif-containing synthetic oligodeoxynucleotide combination therapy for cancer treatment

Publications (1)

Publication Number Publication Date
EA200800268A1 true EA200800268A1 (ru) 2008-06-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800268A EA200800268A1 (ru) 2005-07-07 2006-06-30 КОМБИНИРОВАННАЯ ТЕРАПИЯ АНТИТЕЛОМ ПРОТИВ CTLA-4 И СОДЕРЖАЩИМ CpG-МОТИВ СИНТЕТИЧЕСКИМ ОЛИГОДЕЗОКСИНУКЛЕОТИДОМ ДЛЯ ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННОЙ ОПУХОЛИ

Country Status (17)

Country Link
US (2) US20090117132A1 (ru)
EP (1) EP1904530A2 (ru)
JP (1) JP2009500412A (ru)
KR (1) KR20080030656A (ru)
CN (1) CN101268101A (ru)
AR (1) AR054536A1 (ru)
AU (1) AU2006269555A1 (ru)
BR (1) BRPI0612408A2 (ru)
CA (1) CA2614320A1 (ru)
EA (1) EA200800268A1 (ru)
IL (1) IL188588A0 (ru)
MX (1) MX2008000379A (ru)
NZ (1) NZ565311A (ru)
SG (1) SG163583A1 (ru)
TW (1) TW200801042A (ru)
WO (1) WO2007008463A2 (ru)
ZA (1) ZA200801190B (ru)

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IL188588A0 (en) 2008-04-13
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US20120003179A1 (en) 2012-01-05
MX2008000379A (es) 2008-03-18
AR054536A1 (es) 2007-06-27
AU2006269555A1 (en) 2007-01-18
WO2007008463A2 (en) 2007-01-18
WO2007008463A3 (en) 2007-05-24
BRPI0612408A2 (pt) 2010-11-03
EP1904530A2 (en) 2008-04-02
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KR20080030656A (ko) 2008-04-04
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