ES2175137T3 - Derivados de (imidazol-5-il)metil-2-quinolinona como inhibidores de laproteina farnesil-transferasa. - Google Patents

Derivados de (imidazol-5-il)metil-2-quinolinona como inhibidores de laproteina farnesil-transferasa.

Info

Publication number
ES2175137T3
ES2175137T3 ES96934727T ES96934727T ES2175137T3 ES 2175137 T3 ES2175137 T3 ES 2175137T3 ES 96934727 T ES96934727 T ES 96934727T ES 96934727 T ES96934727 T ES 96934727T ES 2175137 T3 ES2175137 T3 ES 2175137T3
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ES
Spain
Prior art keywords
rent
hydrogen
halo
amino
farnesil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96934727T
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English (en)
Inventor
Marc Gaston Venet
Patrick Rene Angibaud
Philippe Muller
Gerard Charles Sanz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2175137T3 publication Critical patent/ES2175137T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE FORMULA (I), DONDE LA LINEA DISCONTINUA REPRESENTA UN ENLACE OPCIONAL; X ES OXIGENO O AZUFRE; R1 ES HIDROGENO, ALQUILO C1 C12 , AR1 , AR2 ALQUILO C1-C6 , QU INOLINIL ALQUILO C1-C6 , PIRIDIL ALQUILO C1-C6 , HIDROXI ALQUILO C1-C6 , ALQUILOXI C1-C6 ALQUILO C1-C6 , MONO-O DI(ALQUILO C1-C6) AMINO ALQUILO C1-C6 O UN RADICAL DE FORMULA-ALK 1-S(O) 2-R9 ; RSUP,2 , R3 Y R16 , CADA UNO INDEPENDIENTEMENTE, SON HIDROGENO, HIDROXILO, HALO, CIANO, ALQUILO C1-C6 , ALQUILOXI C1-C6 , HIDROXI ALQUILOXI C1 C6 , ALQUILOXI C1-C6 ALQUILOXI C1 C6 , AMINO ALQUILOXI C1-C6 , MONO- O DI-(ALQUIL C1-C6 AMINO ALQUILOXI C1-C6 , AR1 , AR2 ALQUILO C1-C6 , AR2 OXI, AR2 ALQUILOXI C1-C6 , HIDROXICARBONIL ALQUILOXICARBONIL C1-C6 , TRIHALOMETILO, TRIHALOMETOXI, ALQUENILO C2-C6 ; R4 Y R5 SON CADA UNO IND EPENDIENTEMENTE HIDROGENO, HALO, AR1 , ALQUILO C1 C6 , HIDROXI ALQUILO C1-C6 , ALQUILOXI CSUB ,1-C6 ALQUILO C1-C6 , ALQUILOXI C1-C6 , ALQUILTIO C1-C6 , AMINO, HIDROXICARBONILO, ALQUILOXICARBONILO C1-C6 , ALQUIL C1-C6 S(O) ALQUILO C1-C6 O ALQUILO C1-C6 S(O) 2 ALQUILO C1 C6 ; R6 Y R7 SON CADA UNO INDEPENDIENTEMENTE HIDROGENO, HALO, CIANO, ALQUILO C1-C6 , 4, 4 DIMETIL-OXAZOLILO, ALQUILOXI C1-C6 O AR2 OXI; R8 ES HIDROGENO, ALQUILO C1-C6 , CIANO, HIDROXICARBONILO, ALQUILOXICARBONILO C1-C6 , ALQUILCARBONILO C1-C6 ALQUILO C1-C6 , CIANO ALQUILO C1-C6 , ALQUILOXICARBONILO C1 C6 ALQUILO C1-C6 , CARBOXI ALQUILO C1 C6 , HIDROXI ALQUIL C1-C6 AMINO ALQUILO C1-C6 , MONO- O DI(ALQUIL C1-C6 )AMINO ALQUILO C1-C6, IMIDAZOLILO, HALO ALQUILO C1 C6 , ALQUILOXI CSU B,1-C6 ALQUILO C1 C6 , AMINOCARBONIL ALQUILO C1-C6 O UN RADICAL DE FORMULA-O-R10 ,-S-R10 ,-N R11 R12 ; R17 ES HIDROGENO, HALO, CIANO, ALQUILO C1-C6 , ALQUILOXICARBONI LO C1-C6 , AR1 ; R18 ES HIDROGENO, ALQUILO C1-C6 , ALQUILOXI C1-C6 O HALO; R19 ES HIDROGENO O ALQUILO C1-C6 . DICHOS COMPUESTOS PRESENTAN ACTIVIDAD INHIBIDORA DE LA FARNESIL TRANSFERASA. SE DESCRIBE ASIMISMO SU PREPARACION, COMPOSICIONES QUE LOS CONTIENEN Y SU UTILIZACION COMO MEDICAMENTO.
ES96934727T 1995-12-08 1996-10-16 Derivados de (imidazol-5-il)metil-2-quinolinona como inhibidores de laproteina farnesil-transferasa. Expired - Lifetime ES2175137T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95203427 1995-12-08

Publications (1)

Publication Number Publication Date
ES2175137T3 true ES2175137T3 (es) 2002-11-16

Family

ID=8220926

Family Applications (2)

Application Number Title Priority Date Filing Date
ES96934727T Expired - Lifetime ES2175137T3 (es) 1995-12-08 1996-10-16 Derivados de (imidazol-5-il)metil-2-quinolinona como inhibidores de laproteina farnesil-transferasa.
ES01202750T Expired - Lifetime ES2260156T3 (es) 1995-12-08 1996-10-16 Derivados de (imidazol-5-il)metil-2-quinolinona como inhibidores de la proteina farnesil-transferasa.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES01202750T Expired - Lifetime ES2260156T3 (es) 1995-12-08 1996-10-16 Derivados de (imidazol-5-il)metil-2-quinolinona como inhibidores de la proteina farnesil-transferasa.

Country Status (36)

Country Link
US (3) US6037350A (es)
EP (2) EP1162201B1 (es)
JP (1) JP3257559B2 (es)
KR (1) KR100272676B1 (es)
CN (1) CN1101392C (es)
AP (1) AP1108A (es)
AR (1) AR004992A1 (es)
AT (2) ATE321757T1 (es)
AU (1) AU711142B2 (es)
BG (1) BG62615B1 (es)
BR (1) BR9610745A (es)
CA (1) CA2231105C (es)
CY (1) CY2289B1 (es)
CZ (1) CZ293296B6 (es)
DE (2) DE69620445T2 (es)
DK (2) DK1162201T3 (es)
EA (1) EA000710B1 (es)
EE (1) EE03484B1 (es)
ES (2) ES2175137T3 (es)
HK (2) HK1012188A1 (es)
HR (1) HRP960576B1 (es)
HU (1) HU221227B1 (es)
IL (1) IL123568A (es)
MX (1) MX9802068A (es)
MY (1) MY114444A (es)
NO (1) NO314036B1 (es)
NZ (1) NZ320244A (es)
PL (1) PL184171B1 (es)
PT (2) PT865440E (es)
SI (2) SI1162201T1 (es)
SK (1) SK283335B6 (es)
TR (1) TR199800825T2 (es)
TW (1) TW494101B (es)
UA (1) UA57717C2 (es)
WO (1) WO1997021701A1 (es)
ZA (1) ZA9610254B (es)

Families Citing this family (225)

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JP4974438B2 (ja) 2000-09-25 2012-07-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ファルネシルトランスフェラーゼを阻害する６−ヘテロシクリルメチルキノリンおよびキナゾリン誘導体
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