EA201490288A1 - Связывающие молекулы человека, способные нейтрализовать вирусы гриппа a филогенетической группы 1 и филогенетической группы 2 и вирусы гриппа b - Google Patents
Связывающие молекулы человека, способные нейтрализовать вирусы гриппа a филогенетической группы 1 и филогенетической группы 2 и вирусы гриппа bInfo
- Publication number
- EA201490288A1 EA201490288A1 EA201490288A EA201490288A EA201490288A1 EA 201490288 A1 EA201490288 A1 EA 201490288A1 EA 201490288 A EA201490288 A EA 201490288A EA 201490288 A EA201490288 A EA 201490288A EA 201490288 A1 EA201490288 A1 EA 201490288A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- influenza
- viruses
- group
- binding molecules
- phylogenetic
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title 2
- 206010022000 influenza Diseases 0.000 title 2
- 241000712431 Influenza A virus Species 0.000 abstract 2
- 241000713196 Influenza B virus Species 0.000 abstract 2
- 101710154606 Hemagglutinin Proteins 0.000 abstract 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 1
- 101710176177 Protein A56 Proteins 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000000185 hemagglutinin Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
Abstract
Настоящее изобретение относится к связывающим молекулам, таким как моноклональные антитела человека, которые связываются с эпитопом в стволовой области гемагглютинина вируса гриппа А филогенетической группы 1 и группы 2, а также вирусов гриппа В и обладают широкой нейтрализующей активностью, направленной против таких вирусов гриппа. В описании раскрыты молекулы нуклеиновых кислот, кодирующие связывающие молекулы, их последовательности и композиции, содержащие связывающие молекулы. Связывающие молекулы можно применять для диагностики, профилактики и/или лечения в случае вирусов гриппа А филогенетической группы 1 и 2, а также вирусов гриппа В.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161572417P | 2011-07-14 | 2011-07-14 | |
EP11173953 | 2011-07-14 | ||
PCT/EP2012/063637 WO2013007770A1 (en) | 2011-07-14 | 2012-07-12 | Human binding molecules capable of neutralizing influenza a viruses of phylogenetic group 1 and phylogenetic group 2 and influenza b viruses |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201490288A1 true EA201490288A1 (ru) | 2014-05-30 |
EA027054B1 EA027054B1 (ru) | 2017-06-30 |
Family
ID=47505543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201490288A EA027054B1 (ru) | 2011-07-14 | 2012-07-12 | Связывающие молекулы человека, способные нейтрализовать вирусы гриппа a филогенетической группы 1 и филогенетической группы 2 и вирусы гриппа b |
Country Status (17)
Country | Link |
---|---|
US (2) | US8961978B2 (ru) |
EP (1) | EP2731967B1 (ru) |
JP (1) | JP5683752B2 (ru) |
KR (1) | KR101941724B1 (ru) |
CN (1) | CN103906763B (ru) |
AU (1) | AU2012282504B2 (ru) |
BR (1) | BR112014000263B1 (ru) |
CA (1) | CA2838999C (ru) |
DK (1) | DK2731967T3 (ru) |
EA (1) | EA027054B1 (ru) |
ES (1) | ES2608321T3 (ru) |
HR (1) | HRP20161740T1 (ru) |
IL (1) | IL230222A (ru) |
IN (1) | IN2014CN00953A (ru) |
MX (1) | MX346206B (ru) |
MY (1) | MY166282A (ru) |
WO (1) | WO2013007770A1 (ru) |
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US9649375B2 (en) | 2013-03-14 | 2017-05-16 | The Administrators Of The Tulane Educational Fund | Immunogenic peptide conjugate and method for inducing an anti-influenza therapeutic antibody response therewith |
KR20150138236A (ko) * | 2013-03-14 | 2015-12-09 | 콘트라펙트 코포레이션 | 향상된 치료 효능을 위해 비강내로 전달되는 중화 항체에 기반한 조성물 및 방법 |
KR20140118682A (ko) * | 2013-03-29 | 2014-10-08 | (주)셀트리온 | 2 이상의 인플루엔자 a 바이러스 중화 결합 분자를 포함하는 조성물 |
CA2913859C (en) | 2013-05-30 | 2021-11-30 | Crucell Holland B.V. | Influenza virus vaccines and uses thereof |
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RU2682049C2 (ru) * | 2014-01-27 | 2019-03-14 | Дженентек, Инк. | Лечение вируса гриппа а h7n9 |
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HRP20220980T1 (hr) | 2018-01-23 | 2022-11-11 | Janssen Vaccines & Prevention B.V. | Cjepiva protiv virusa influence i njihova uporaba |
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MX346206B (es) | 2011-07-14 | 2017-03-09 | Crucell Holland Bv | Moleculas de enlace humanas capaces de neutralizar los virus de la influenza a del grupo filogenetico 1 y grupo filogenetico 2 y virus de la influenza b. |
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2012
- 2012-07-12 MX MX2014000373A patent/MX346206B/es active IP Right Grant
- 2012-07-12 DK DK12735516.2T patent/DK2731967T3/en active
- 2012-07-12 EA EA201490288A patent/EA027054B1/ru not_active IP Right Cessation
- 2012-07-12 WO PCT/EP2012/063637 patent/WO2013007770A1/en active Application Filing
- 2012-07-12 BR BR112014000263-0A patent/BR112014000263B1/pt active IP Right Grant
- 2012-07-12 KR KR1020137035132A patent/KR101941724B1/ko active IP Right Grant
- 2012-07-12 US US14/126,404 patent/US8961978B2/en active Active
- 2012-07-12 MY MYPI2014700068A patent/MY166282A/en unknown
- 2012-07-12 EP EP12735516.2A patent/EP2731967B1/en active Active
- 2012-07-12 AU AU2012282504A patent/AU2012282504B2/en active Active
- 2012-07-12 CN CN201280034558.0A patent/CN103906763B/zh active Active
- 2012-07-12 IN IN953CHN2014 patent/IN2014CN00953A/en unknown
- 2012-07-12 JP JP2014519551A patent/JP5683752B2/ja active Active
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2013
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CN103906763A (zh) | 2014-07-02 |
MY166282A (en) | 2018-06-25 |
HRP20161740T1 (hr) | 2017-02-10 |
WO2013007770A1 (en) | 2013-01-17 |
KR20140095017A (ko) | 2014-07-31 |
AU2012282504B2 (en) | 2017-07-20 |
MX2014000373A (es) | 2014-03-31 |
US20140120113A1 (en) | 2014-05-01 |
BR112014000263B1 (pt) | 2022-01-18 |
JP2014527403A (ja) | 2014-10-16 |
US8961978B2 (en) | 2015-02-24 |
EA027054B1 (ru) | 2017-06-30 |
EP2731967A1 (en) | 2014-05-21 |
ES2608321T3 (es) | 2017-04-07 |
IN2014CN00953A (ru) | 2015-04-10 |
KR101941724B1 (ko) | 2019-01-23 |
BR112014000263A2 (pt) | 2017-02-14 |
US20150274811A1 (en) | 2015-10-01 |
JP5683752B2 (ja) | 2015-03-11 |
CA2838999C (en) | 2021-02-16 |
DK2731967T3 (en) | 2017-01-16 |
CA2838999A1 (en) | 2013-01-17 |
IL230222A (en) | 2017-09-28 |
MX346206B (es) | 2017-03-09 |
US9593159B2 (en) | 2017-03-14 |
AU2012282504A1 (en) | 2014-02-06 |
EP2731967B1 (en) | 2016-10-12 |
CN103906763B (zh) | 2016-10-12 |
NZ618530A (en) | 2016-05-27 |
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