EA201500140A1 - Ослабленные вакцины от свиного гриппа и способы их получения и применения - Google Patents
Ослабленные вакцины от свиного гриппа и способы их получения и примененияInfo
- Publication number
- EA201500140A1 EA201500140A1 EA201500140A EA201500140A EA201500140A1 EA 201500140 A1 EA201500140 A1 EA 201500140A1 EA 201500140 A EA201500140 A EA 201500140A EA 201500140 A EA201500140 A EA 201500140A EA 201500140 A1 EA201500140 A1 EA 201500140A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- vaccines
- faced
- receiving
- application
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16161—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Представлены ослабленные штаммы вируса свиного гриппа, в частности те, что получены методами обратной генетики, содержащие их композиции и способы их получения и применения. Ослабленные штаммы подвергались инженерии с тем, чтобы они кодировали белки НА, содержащие дополнительные сайты гликозилирования по сравнению с белками НА, кодируемыми соответствующими исходными вирулентными вирусами. Предпочтительно ослабленные штаммы вируса гриппа вводятся свиньям для выработки у них эффективного иммунитета против гриппа или заболеваний, вызванных вирусом гриппа.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261672398P | 2012-07-17 | 2012-07-17 | |
PCT/US2013/050000 WO2014014726A1 (en) | 2012-07-17 | 2013-07-11 | Attenuated swine influenza vaccines and methods of making and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201500140A1 true EA201500140A1 (ru) | 2016-02-29 |
EA033027B1 EA033027B1 (ru) | 2019-08-30 |
Family
ID=48874529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201500140A EA033027B1 (ru) | 2012-07-17 | 2013-07-11 | Ослабленные вакцины от свиного гриппа и способы их получения и применения |
Country Status (20)
Country | Link |
---|---|
US (2) | US9216211B2 (ru) |
EP (1) | EP2874656B1 (ru) |
JP (1) | JP6467672B2 (ru) |
KR (1) | KR102027758B1 (ru) |
CN (1) | CN104582725B (ru) |
AU (2) | AU2013290597B2 (ru) |
BR (1) | BR112015001020B1 (ru) |
CA (1) | CA2879228C (ru) |
DK (1) | DK2874656T3 (ru) |
EA (1) | EA033027B1 (ru) |
ES (1) | ES2662022T3 (ru) |
HK (1) | HK1209325A1 (ru) |
HU (1) | HUE036110T2 (ru) |
MX (1) | MX365880B (ru) |
MY (1) | MY166879A (ru) |
NZ (2) | NZ712713A (ru) |
PH (1) | PH12015500095A1 (ru) |
PL (1) | PL2874656T3 (ru) |
PT (1) | PT2874656T (ru) |
WO (1) | WO2014014726A1 (ru) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014014726A1 (en) | 2012-07-17 | 2014-01-23 | Merial Limited | Attenuated swine influenza vaccines and methods of making and use thereof |
MY191905A (en) * | 2015-12-28 | 2022-07-18 | Boehringer Ingelheim Animal Health Usa Inc | M hyo multivalent vaccine and uses thereof |
EP3548078A1 (en) | 2016-11-30 | 2019-10-09 | Boehringer Ingelheim Animal Health USA Inc. | Attenuated swine influenza vaccines and methods of making and use thereof |
CN106939355A (zh) * | 2017-03-01 | 2017-07-11 | 苏州系统医学研究所 | 一种流感病毒弱毒活疫苗毒株的筛选和鉴定方法 |
CN107064499B (zh) * | 2017-03-15 | 2019-06-18 | 青岛蔚蓝生物制品有限公司 | 禽流感病毒np蛋白抗原表位多肽及其胶体金试纸盒 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0138854B1 (en) | 1983-03-08 | 1992-11-04 | Chiron Mimotopes Pty. Ltd. | Antigenically active amino acid sequences |
US5585250A (en) | 1993-08-20 | 1996-12-17 | The United States Of America As Represented By The Department Of Health & Human Services | Dampening of an immunodominant epitope of an antigen for use in plant, animal and human compositions and immunotherapies |
EP0930893B1 (en) | 1996-10-11 | 2005-04-13 | The Regents of The University of California | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
US5980912A (en) | 1997-03-25 | 1999-11-09 | Zonagen, Inc. | Chitosan induced immunopotentiation |
WO2005028658A2 (en) | 2003-05-28 | 2005-03-31 | Wisconsin Alumni Research Foundation | Recombinant influenza vectors with a polii promoter and ribozymes |
US7871626B2 (en) * | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
EP2674486A1 (en) * | 2007-06-18 | 2013-12-18 | MedImmune, LLC | Influenza B viruses having alterations in the hemaglutinin polypeptide |
WO2009105729A2 (en) | 2008-02-21 | 2009-08-27 | Biological Mimetics, Inc. | Immunogenic influenza composition |
EP2525818A4 (en) * | 2010-01-24 | 2013-10-02 | Biolog Mimetics Inc | IMMUNOGENIC COMPOSITION OF INFLUENZA VIRUSES |
WO2014014726A1 (en) * | 2012-07-17 | 2014-01-23 | Merial Limited | Attenuated swine influenza vaccines and methods of making and use thereof |
-
2013
- 2013-07-11 WO PCT/US2013/050000 patent/WO2014014726A1/en active Application Filing
- 2013-07-11 BR BR112015001020-2A patent/BR112015001020B1/pt active IP Right Grant
- 2013-07-11 PL PL13740452T patent/PL2874656T3/pl unknown
- 2013-07-11 PT PT137404521T patent/PT2874656T/pt unknown
- 2013-07-11 CA CA2879228A patent/CA2879228C/en active Active
- 2013-07-11 EA EA201500140A patent/EA033027B1/ru not_active IP Right Cessation
- 2013-07-11 US US13/939,321 patent/US9216211B2/en active Active
- 2013-07-11 HU HUE13740452A patent/HUE036110T2/hu unknown
- 2013-07-11 DK DK13740452.1T patent/DK2874656T3/en active
- 2013-07-11 AU AU2013290597A patent/AU2013290597B2/en active Active
- 2013-07-11 NZ NZ712713A patent/NZ712713A/en unknown
- 2013-07-11 MY MYPI2015000100A patent/MY166879A/en unknown
- 2013-07-11 CN CN201380043383.4A patent/CN104582725B/zh active Active
- 2013-07-11 ES ES13740452.1T patent/ES2662022T3/es active Active
- 2013-07-11 MX MX2015000713A patent/MX365880B/es active IP Right Grant
- 2013-07-11 EP EP13740452.1A patent/EP2874656B1/en active Active
- 2013-07-11 JP JP2015523130A patent/JP6467672B2/ja active Active
- 2013-07-11 KR KR1020157004138A patent/KR102027758B1/ko active IP Right Grant
- 2013-07-11 NZ NZ704188A patent/NZ704188A/en unknown
-
2015
- 2015-01-14 PH PH12015500095A patent/PH12015500095A1/en unknown
- 2015-10-14 HK HK15110019.9A patent/HK1209325A1/xx unknown
- 2015-12-21 US US14/977,485 patent/US9623105B2/en active Active
-
2016
- 2016-04-27 AU AU2016202693A patent/AU2016202693B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MD3718565T2 (ro) | Vaccinuri împotriva virusului respirator | |
PH12015502553A1 (en) | Human binding molecules capable of binding to and neutralizing influenza b viruses and uses thereof | |
EA201591164A1 (ru) | Вакцины против вируса гриппа и их применение | |
MX2016003419A (es) | Metodos y composiciones para sindrome respiratorio coronavirus de oriente medio (mers-cov) inmunogenico. | |
MX359954B (es) | Ácido nucleico que comprende o codifica para un asa troncal de histona y una secuencia poly (a) o una señal de poliadenilación para aumentar la expresión de un antígeno patogénico codificado. | |
EA201490659A1 (ru) | Вакцины против вируса гриппа и их применения | |
EA201992133A1 (ru) | Производные пиперидино-пиримидина для лечения вирусных инфекций | |
EA201790294A1 (ru) | Средства на основе флагеллина и применения, включающие эффективную вакцинацию | |
EA201590343A1 (ru) | Алкилпиримидиновые производные для лечения вирусных инфекций и дальнейших заболеваний | |
EA201490288A1 (ru) | Связывающие молекулы человека, способные нейтрализовать вирусы гриппа a филогенетической группы 1 и филогенетической группы 2 и вирусы гриппа b | |
EA201590667A1 (ru) | Ациламинопиримидиновые производные для лечения вирусных инфекций и других заболеваний | |
EA201500383A1 (ru) | Производные 1,2,4-триазина для лечения вирусных инфекций | |
NZ630869A (en) | Compositions and methods for dengue virus chimeric constructs in vaccines | |
EA201490610A1 (ru) | Соединения и способы усиления врожденных иммунных ответов | |
PH12017501370A1 (en) | Bivalent swine influenza virus vaccine | |
EA201391515A1 (ru) | Инактивированная вакцина вируса денге | |
EA201590491A1 (ru) | Иммуногенная композиция | |
EA201500140A1 (ru) | Ослабленные вакцины от свиного гриппа и способы их получения и применения | |
MY189495A (en) | Hand, foot, and mouth vaccines and methods of manufacture and use thereof | |
MX2015007753A (es) | Composicion de vacunas para sujetos intactos. | |
NZ731659A (en) | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus | |
MX2017016896A (es) | Vacunas inactivadas contra la influenza canina, metodos para elaborarlas y sus usos. | |
MX2013003245A (es) | Vacuna contra virus de diarrea viral de bovinos. | |
BR112013023354A2 (pt) | vacina para rinite equina | |
EA201991319A1 (ru) | Вакцины аттенуированного свиного гриппа и способы их изготовления и применения |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |