EA200970255A1 - Связывающие молекулы человека, способные нейтрализовать вирус гриппа h5n1, и их применение - Google Patents

Связывающие молекулы человека, способные нейтрализовать вирус гриппа h5n1, и их применение

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Publication number
EA200970255A1
EA200970255A1 EA200970255A EA200970255A EA200970255A1 EA 200970255 A1 EA200970255 A1 EA 200970255A1 EA 200970255 A EA200970255 A EA 200970255A EA 200970255 A EA200970255 A EA 200970255A EA 200970255 A1 EA200970255 A1 EA 200970255A1
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Eurasian Patent Office
Prior art keywords
antibodies
influenza virus
binding molecules
neutralize
influenza
Prior art date
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EA200970255A
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English (en)
Other versions
EA017203B1 (ru
Inventor
Эдвард Норберт Ван Ден Бринк
Корнелис Адриан Де Крэйф
Марк Тросби
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Круселл Холланд Б.В.
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Application filed by Круселл Холланд Б.В. filed Critical Круселл Холланд Б.В.
Publication of EA200970255A1 publication Critical patent/EA200970255A1/ru
Publication of EA017203B1 publication Critical patent/EA017203B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/56983—Viruses
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Abstract

Настоящее изобретение относится к связывающим молекулам, таким как моноклональные антитела человека, которые связываются с вирусом гриппа H5N1 и обладают нейтрализующей активностью в отношении вируса гриппа H5N1. Настоящее изобретение относится к молекулам нуклеиновых кислот, кодирующим антитела, их последовательностям и композициям, включающим указанные антитела, а также к способам идентификации или получения антител. Указанные антитела могут быть использованы для диагностики, профилактики и/или лечения гриппа, вызываемого вирусом гриппа H5N1. В предпочтительном варианте осуществления изобретения указанные антитела обеспечивают перекрестную защиту in vivo от разных подтипов вируса гриппа, что позволяет предотвратить и/или лечить грипп, вызываемый подтипами вируса гриппа на основе Н5, Н2, Н6, Н9 и H1.
EA200970255A 2006-09-07 2007-09-06 Связывающие молекулы человека, способные нейтрализовать вирус гриппа h5n1, и их применение EA017203B1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US84293006P 2006-09-07 2006-09-07
EP06120316 2006-09-07
EP06120644 2006-09-14
EP06125107 2006-11-30
EP07111235 2007-06-28
PCT/EP2007/059356 WO2008028946A2 (en) 2006-09-07 2007-09-06 Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof

Publications (2)

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EA200970255A1 true EA200970255A1 (ru) 2009-10-30
EA017203B1 EA017203B1 (ru) 2012-10-30

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EA200970255A EA017203B1 (ru) 2006-09-07 2007-09-06 Связывающие молекулы человека, способные нейтрализовать вирус гриппа h5n1, и их применение

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US (5) US8192927B2 (ru)
EP (2) EP2059532B1 (ru)
JP (2) JP5161882B2 (ru)
KR (1) KR101485197B1 (ru)
AU (1) AU2007293662B2 (ru)
CA (1) CA2663388C (ru)
EA (1) EA017203B1 (ru)
HK (1) HK1126799A1 (ru)
HR (1) HRP20130163T1 (ru)
IL (2) IL197390A (ru)
MX (1) MX2009002174A (ru)
MY (1) MY170607A (ru)
NO (1) NO20091321L (ru)
PL (1) PL2059532T3 (ru)
WO (1) WO2008028946A2 (ru)
ZA (1) ZA200901171B (ru)

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