MX2016004249A - Polinulcleotidos que codifican el receptor de lipoproteina de baja densidad. - Google Patents

Polinulcleotidos que codifican el receptor de lipoproteina de baja densidad.

Info

Publication number
MX2016004249A
MX2016004249A MX2016004249A MX2016004249A MX2016004249A MX 2016004249 A MX2016004249 A MX 2016004249A MX 2016004249 A MX2016004249 A MX 2016004249A MX 2016004249 A MX2016004249 A MX 2016004249A MX 2016004249 A MX2016004249 A MX 2016004249A
Authority
MX
Mexico
Prior art keywords
low density
density lipoprotein
lipoprotein receptor
polynucleotides encoding
encoding low
Prior art date
Application number
MX2016004249A
Other languages
English (en)
Inventor
Guild Justin
Lynn Ellsworth Jeff
Beene Bolen Josepeh
M Gregoire Francine
Original Assignee
Moderna Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Moderna Therapeutics Inc filed Critical Moderna Therapeutics Inc
Publication of MX2016004249A publication Critical patent/MX2016004249A/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/485Epidermal growth factor [EGF], i.e. urogastrone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/317Chemical structure of the backbone with an inverted bond, e.g. a cap structure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/334Modified C
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/335Modified T or U

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La invención se refiere a composiciones y métodos para la preparación, fabricación y uso terapéutico de moléculas de polinucleótido, que codifican el receptor de lipoproteína de baja densidad que comprende al menos una mutación (por ejemplo, una mutación que aumenta la señalización LDLR).
MX2016004249A 2013-10-03 2014-10-03 Polinulcleotidos que codifican el receptor de lipoproteina de baja densidad. MX2016004249A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361886137P 2013-10-03 2013-10-03
US201361903485P 2013-11-13 2013-11-13
US201461952906P 2014-03-14 2014-03-14
US201462052139P 2014-09-18 2014-09-18
PCT/US2014/058967 WO2015051214A1 (en) 2013-10-03 2014-10-03 Polynucleotides encoding low density lipoprotein receptor

Publications (1)

Publication Number Publication Date
MX2016004249A true MX2016004249A (es) 2016-11-08

Family

ID=51799314

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016004249A MX2016004249A (es) 2013-10-03 2014-10-03 Polinulcleotidos que codifican el receptor de lipoproteina de baja densidad.

Country Status (13)

Country Link
US (2) US10323076B2 (es)
EP (1) EP3052521A1 (es)
JP (1) JP2016538829A (es)
KR (1) KR20160067219A (es)
CN (1) CN105980401A (es)
AU (1) AU2014329452B2 (es)
BR (1) BR112016007255A2 (es)
CA (1) CA2926218A1 (es)
EA (1) EA201690675A1 (es)
IL (1) IL244837A0 (es)
MX (1) MX2016004249A (es)
SG (1) SG11201602503TA (es)
WO (1) WO2015051214A1 (es)

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KR20160067219A (ko) 2016-06-13
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AU2014329452B2 (en) 2019-06-20
CN105980401A (zh) 2016-09-28
US10323076B2 (en) 2019-06-18
WO2015051214A1 (en) 2015-04-09
JP2016538829A (ja) 2016-12-15
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EP3052521A1 (en) 2016-08-10
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