MX363434B - Produccion incrementada de terpenos y terpenoides. - Google Patents

Produccion incrementada de terpenos y terpenoides.

Info

Publication number
MX363434B
MX363434B MX2015002124A MX2015002124A MX363434B MX 363434 B MX363434 B MX 363434B MX 2015002124 A MX2015002124 A MX 2015002124A MX 2015002124 A MX2015002124 A MX 2015002124A MX 363434 B MX363434 B MX 363434B
Authority
MX
Mexico
Prior art keywords
terpenoids
terpenes
increased production
accumulation
methods
Prior art date
Application number
MX2015002124A
Other languages
English (en)
Other versions
MX2015002124A (es
Inventor
Oestergaard Tange Thomas
Naesby Michael
Folly Christophe
Delegrange Fanny
Carlsen Simon
Houghton-Larsen Jens
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of MX2015002124A publication Critical patent/MX2015002124A/es
Publication of MX363434B publication Critical patent/MX363434B/es

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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01068—(2Z,6E)-Farnesyl diphosphate synthase (2.5.1.68)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Esta invención proporciona células recombinantes y métodos para producir terpenos y terpenoides al incrementar la producción o acumulación, o ambos, de precursores isoprenoides de los mismos.
MX2015002124A 2012-08-17 2013-08-19 Produccion incrementada de terpenos y terpenoides. MX363434B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261684422P 2012-08-17 2012-08-17
US201261745164P 2012-12-21 2012-12-21
PCT/EP2013/067262 WO2014027118A1 (en) 2012-08-17 2013-08-19 Increased production of terpenes and terpenoids

Publications (2)

Publication Number Publication Date
MX2015002124A MX2015002124A (es) 2015-08-14
MX363434B true MX363434B (es) 2019-03-22

Family

ID=48998624

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015002124A MX363434B (es) 2012-08-17 2013-08-19 Produccion incrementada de terpenos y terpenoides.

Country Status (10)

Country Link
US (2) US9834800B2 (es)
EP (1) EP2885420B1 (es)
CN (1) CN104583416A (es)
AU (1) AU2013304001B2 (es)
BR (1) BR112015003329A2 (es)
CA (1) CA2880962C (es)
DK (1) DK2885420T3 (es)
HK (1) HK1211984A1 (es)
MX (1) MX363434B (es)
WO (1) WO2014027118A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX363434B (es) 2012-08-17 2019-03-22 Evolva Sa Produccion incrementada de terpenos y terpenoides.
MX2015016379A (es) * 2013-05-31 2016-04-13 Dsm Ip Assets Bv Produccion de diterpeno extracelular.
CN107466320B (zh) 2014-10-01 2021-11-05 埃沃尔瓦公司 用于生物合成罗汉果苷化合物的方法和材料
CN104694556A (zh) * 2014-12-14 2015-06-10 上海勤生缘生物科技有限公司 牛樟芝fpps蛋白基因及其克隆和测序方法
EP3303599A4 (en) * 2015-04-09 2019-05-01 Firmenich SA MANUFACTURE OF ODORANT COMPOUNDS
PT3368673T (pt) * 2015-10-29 2020-08-27 Amyris Inc Composições e métodos para a produção de mirceno
MY190296A (en) 2015-10-29 2022-04-12 Firmenich Incorporated High intensity sweeteners
EP3380497A1 (en) * 2015-11-27 2018-10-03 Evolva SA Production of terpenes, terpenoids, and derivatives thereof in recombinant hosts
EP3478844A4 (en) * 2016-07-01 2020-04-08 International Flavors & Fragrances Inc. COMPOSITIONS AND METHODS FOR PRODUCING CITRUS TERPENOIDS
WO2018053507A2 (en) * 2016-09-19 2018-03-22 Evolva Sa Production of sesquiterpene products and related molecules
JP7105783B2 (ja) * 2016-10-11 2022-07-25 高砂香料工業株式会社 組換え宿主におけるシトロネラール及びシトロネロールの生産
CN108085262B (zh) * 2016-11-23 2022-08-05 中国科学院天津工业生物技术研究所 对萜类或含萜精油耐受性提高或萜类产量提高的重组宿主细胞、其产生方法及其用途
ES2959508T3 (es) 2017-01-26 2024-02-26 Manus Bio Inc Ingeniería metabólica para la producción microbiana de productos terpenoides
WO2018144996A1 (en) 2017-02-03 2018-08-09 Manus Bio, Inc. Metabolic engineering for microbial production of terpenoid products
BR112019023104A2 (pt) 2017-05-03 2020-11-03 Firmenich Incorporated métodos para fazer adoçante de alta intensidade
JP2021505154A (ja) 2017-12-07 2021-02-18 ザイマージェン インコーポレイテッド 発酵によって（６ｅ）−８−ヒドロキシゲラニオールを生産するための設計された生合成経路
EP3728212A1 (en) 2017-12-21 2020-10-28 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
CN111434773B (zh) * 2019-01-15 2021-06-18 天津大学 一种高产檀香油的重组酵母菌及其构建方法与应用
WO2020176547A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
WO2020180736A2 (en) * 2019-03-01 2020-09-10 The Regents Of The University Of California Production of cannabinoids using genetically engineered photosynthetic microorganisms
CN109913380B (zh) * 2019-03-25 2021-12-10 南京工业大学 生产(-)-α-红没药醇的重组解脂耶氏酵母菌及其构建方法和应用
CN110229804A (zh) * 2019-05-23 2019-09-13 天津大学 一种柠檬烯合成酶SynLS1及其应用
CN110747206B (zh) * 2019-11-05 2021-11-23 昆明理工大学 3-羟基-3-甲基戊二酸单酰辅酶a还原酶基因rkhmgr及其应用
WO2021140232A1 (en) 2020-01-10 2021-07-15 Barrit Sarl; Rcs 878 023 431 Production of bioactive bibenzylic acid or derivatives thereof by genetically modified microbial hosts
CN114181964B (zh) * 2021-11-02 2023-06-09 云南大学 一种表达盒组合、重组载体和重组酿酒酵母及其应用
NL2032683B1 (en) * 2022-07-18 2024-01-26 Sestina Bio Llc Bioproduction of isoprenoids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2622208B1 (fr) * 1987-10-22 1991-02-15 Pernod Ricard Procede d'obtention d'aromes terpeniques par un procede microbiologique
WO2000001686A1 (en) * 1998-07-06 2000-01-13 Eastman Chemical Company Method of producing vitamin e
CA2433529A1 (en) * 2000-12-28 2002-07-11 Toyota Jidosha Kabushiki Kaisha Process for producing prenyl alcohol
US8986965B2 (en) * 2010-03-31 2015-03-24 Codexis, Inc. Production of monoterpenes
EP2794863A1 (en) 2011-12-23 2014-10-29 Danisco US Inc. Enhanced production of isoprene using host cells having decreased ispa activity
MX363434B (es) 2012-08-17 2019-03-22 Evolva Sa Produccion incrementada de terpenos y terpenoides.

Also Published As

Publication number Publication date
DK2885420T3 (en) 2019-03-25
AU2013304001A1 (en) 2015-02-26
AU2013304001B2 (en) 2019-01-03
CA2880962C (en) 2019-07-30
CA2880962A1 (en) 2014-02-20
EP2885420B1 (en) 2018-12-05
US9834800B2 (en) 2017-12-05
EP2885420A1 (en) 2015-06-24
HK1211984A1 (en) 2016-06-03
CN104583416A (zh) 2015-04-29
US10190140B2 (en) 2019-01-29
US20180080054A1 (en) 2018-03-22
US20150225754A1 (en) 2015-08-13
MX2015002124A (es) 2015-08-14
WO2014027118A1 (en) 2014-02-20
BR112015003329A2 (pt) 2017-09-26

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