BR112015003329A2 - produção aumentada de terpenos e terpenoides - Google Patents

produção aumentada de terpenos e terpenoides

Info

Publication number
BR112015003329A2
BR112015003329A2 BR112015003329A BR112015003329A BR112015003329A2 BR 112015003329 A2 BR112015003329 A2 BR 112015003329A2 BR 112015003329 A BR112015003329 A BR 112015003329A BR 112015003329 A BR112015003329 A BR 112015003329A BR 112015003329 A2 BR112015003329 A2 BR 112015003329A2
Authority
BR
Brazil
Prior art keywords
terpenoids
terpenes
increased production
production
abstract
Prior art date
Application number
BR112015003329A
Other languages
English (en)
Inventor
Folly Christophe
Delegrange Fanny
Houghton Jens
Naesby Michael
Carlsen Simon
Oestergaard Tange Thomas
Original Assignee
Evolva Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolva Sa filed Critical Evolva Sa
Publication of BR112015003329A2 publication Critical patent/BR112015003329A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01068—(2Z,6E)-Farnesyl diphosphate synthase (2.5.1.68)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Botany (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

resumo “produção aumentada de terpenos e terpenoides” a presente invenção refere-se a células recombinantes e métodos para a produção de terpenos e terpenoides por aumento da produção ou acúmulo ou ambos de seus precursores de isoprenoide.
BR112015003329A 2012-08-17 2013-08-19 produção aumentada de terpenos e terpenoides BR112015003329A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261684422P 2012-08-17 2012-08-17
US201261745164P 2012-12-21 2012-12-21
PCT/EP2013/067262 WO2014027118A1 (en) 2012-08-17 2013-08-19 Increased production of terpenes and terpenoids

Publications (1)

Publication Number Publication Date
BR112015003329A2 true BR112015003329A2 (pt) 2017-09-26

Family

ID=48998624

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015003329A BR112015003329A2 (pt) 2012-08-17 2013-08-19 produção aumentada de terpenos e terpenoides

Country Status (10)

Country Link
US (2) US9834800B2 (pt)
EP (1) EP2885420B1 (pt)
CN (1) CN104583416A (pt)
AU (1) AU2013304001B2 (pt)
BR (1) BR112015003329A2 (pt)
CA (1) CA2880962C (pt)
DK (1) DK2885420T3 (pt)
HK (1) HK1211984A1 (pt)
MX (1) MX363434B (pt)
WO (1) WO2014027118A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX363434B (es) 2012-08-17 2019-03-22 Evolva Sa Produccion incrementada de terpenos y terpenoides.
CA2912347A1 (en) * 2013-05-31 2014-12-04 Dsm Ip Assets B.V. Extracellular diterpene production
CA2963300C (en) 2014-10-01 2024-04-30 Evolva Sa Methods and materials for biosynthesis of mogroside compounds
CN104694556A (zh) * 2014-12-14 2015-06-10 上海勤生缘生物科技有限公司 牛樟芝fpps蛋白基因及其克隆和测序方法
CN107849586B (zh) * 2015-04-09 2021-11-30 弗门尼舍有限公司 芳香化合物的生产
CA3003163A1 (en) 2015-10-29 2017-05-04 Senomyx, Inc. High intensity sweeteners
EP3368673B1 (en) * 2015-10-29 2020-07-29 Amyris, Inc. Compositions and methods for production of myrcene
WO2017089590A1 (en) * 2015-11-27 2017-06-01 Evolva Sa Production of terpenes, terpenoids, and derivatives thereof in recombinant hosts
EP3478844A4 (en) * 2016-07-01 2020-04-08 International Flavors & Fragrances Inc. COMPOSITIONS AND METHODS FOR PRODUCING CITRUS TERPENOIDS
WO2018053507A2 (en) * 2016-09-19 2018-03-22 Evolva Sa Production of sesquiterpene products and related molecules
US11299717B2 (en) 2016-10-11 2022-04-12 Evolva Sa Production of citronellal and citronellol in recombinant hosts
CN108085262B (zh) * 2016-11-23 2022-08-05 中国科学院天津工业生物技术研究所 对萜类或含萜精油耐受性提高或萜类产量提高的重组宿主细胞、其产生方法及其用途
AU2018211953A1 (en) 2017-01-26 2019-08-15 Manus Bio, Inc. Metabolic engineering for microbial production of terpenoid products
AU2018215537B2 (en) 2017-02-03 2023-11-09 Manus Bio, Inc. Metabolic engineering for microbial production of terpenoid products
SG11201910136RA (en) 2017-05-03 2019-11-28 Firmenich Incorporated Methods for making high intensity sweeteners
JP2021505154A (ja) 2017-12-07 2021-02-18 ザイマージェン インコーポレイテッド 発酵によって（６ｅ）−８−ヒドロキシゲラニオールを生産するための設計された生合成経路
EP3728212A1 (en) 2017-12-21 2020-10-28 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
CN111434773B (zh) * 2019-01-15 2021-06-18 天津大学 一种高产檀香油的重组酵母菌及其构建方法与应用
EP3931330A4 (en) 2019-02-25 2023-03-15 Ginkgo Bioworks, Inc. BIOSYNTHESIS OF CANNABINOIDS AND CANNABINOID PRECURSORS
WO2020180736A2 (en) * 2019-03-01 2020-09-10 The Regents Of The University Of California Production of cannabinoids using genetically engineered photosynthetic microorganisms
CN109913380B (zh) * 2019-03-25 2021-12-10 南京工业大学 生产(-)-α-红没药醇的重组解脂耶氏酵母菌及其构建方法和应用
CN110229804A (zh) * 2019-05-23 2019-09-13 天津大学 一种柠檬烯合成酶SynLS1及其应用
CN110747206B (zh) * 2019-11-05 2021-11-23 昆明理工大学 3-羟基-3-甲基戊二酸单酰辅酶a还原酶基因rkhmgr及其应用
US20230257785A1 (en) 2020-01-10 2023-08-17 Barrit Sarl Production of bioactive bibenzylic acid or derivatives thereof by genetically modified microbial hosts
CN114181964B (zh) * 2021-11-02 2023-06-09 云南大学 一种表达盒组合、重组载体和重组酿酒酵母及其应用
NL2032683B1 (en) * 2022-07-18 2024-01-26 Sestina Bio Llc Bioproduction of isoprenoids

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2622208B1 (fr) * 1987-10-22 1991-02-15 Pernod Ricard Procede d'obtention d'aromes terpeniques par un procede microbiologique
CN1315947A (zh) * 1998-07-06 2001-10-03 伊斯曼化学公司 生育酚的制备
US7501268B2 (en) * 2000-12-28 2009-03-10 Toyota Jidosha Kabushiki Kaisha Methods of producing prenyl alcohols
EP2553108A4 (en) 2010-03-31 2015-01-28 Codexis Inc PRODUCTION OF MONOTERPENES
MX2014007623A (es) 2011-12-23 2015-02-04 Danisco Us Inc Produccion mejorada de isopreno con el uso de celulas hospederas que tienen actividad de ispa reducida.
MX363434B (es) 2012-08-17 2019-03-22 Evolva Sa Produccion incrementada de terpenos y terpenoides.

Also Published As

Publication number Publication date
EP2885420B1 (en) 2018-12-05
AU2013304001A1 (en) 2015-02-26
DK2885420T3 (en) 2019-03-25
HK1211984A1 (en) 2016-06-03
US20150225754A1 (en) 2015-08-13
AU2013304001B2 (en) 2019-01-03
US10190140B2 (en) 2019-01-29
WO2014027118A1 (en) 2014-02-20
MX2015002124A (es) 2015-08-14
MX363434B (es) 2019-03-22
CN104583416A (zh) 2015-04-29
EP2885420A1 (en) 2015-06-24
CA2880962A1 (en) 2014-02-20
US9834800B2 (en) 2017-12-05
US20180080054A1 (en) 2018-03-22
CA2880962C (en) 2019-07-30

Similar Documents

Publication Publication Date Title
BR112015003329A2 (pt) produção aumentada de terpenos e terpenoides
MX2016007671A (es) Metodo para producir celulas del epitelio pigmentario retiniano.
CR20140020A (es) Compuestos inhibidores de metaloenzimas
BR112015024186A2 (pt) composições e métodos para produção e manutenção de cetose elevada
BR112013032028A2 (pt) processo para produção de grafeno
CO6900122A2 (es) Fallo del cliente en clúster
EP3052638A4 (en) Glucosyl stevia composition
BR112013028187A2 (pt) processo para produzir olefinas
EP3052630A4 (en) Recombinant microorganism for improved production of fine chemicals
EP3080273A4 (en) Recombinant microorganism for improved production of fine chemicals
WO2013166211A3 (en) Identification of isoprene synthase variants with improved properties for the production of isoprene
IN2015DN00924A (pt)
BR102014033125A8 (pt) Seleção baseada em valor de haploide ideal para criar linhagens de elite
EP3048094A4 (en) Bis(amino-methyl)cyclohexane production method
BR112015029399A2 (pt) produção em etapa única de uma composição de polipropileno
BR112017005109A2 (pt) produto refratário com base em al2o3, composição de matérias-primas para a fabricação do produto, método para a fabricação de um produto refratário, produto refratário, e emprego do produto refratário
BR112013032218A2 (pt) método para coprodução de hidrocarbonetos
EP3039121A4 (en) Modified microorganism for improved production of alanine
BR112013024193A2 (pt) método para a produção de uma estrutura útil para a produção de um gerador termelétrico, estutura útil, gerador termelétrico
BR112015022233A2 (pt) nanopartículas de lípidos sólidos
BR112015022234A2 (pt) nanopartículas de lípidos sólidos (ii)
BR112015030684A2 (pt) método para a produção de copoliamidas parcialmente aromáticas com elevado excesso de diamina
WO2014118606A3 (en) A novel process for the preparation of silodosin
BR112015015373A2 (pt) métodos de integração da produção de aluminoxano na produçâo de catalisador
PL2883461T3 (pl) Sposób wytwarzania aktywnej folistatyny

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time