SG11201910136RA - Methods for making high intensity sweeteners - Google Patents
Methods for making high intensity sweetenersInfo
- Publication number
- SG11201910136RA SG11201910136RA SG11201910136RA SG11201910136RA SG 11201910136R A SG11201910136R A SG 11201910136RA SG 11201910136R A SG11201910136R A SG 11201910136RA SG 11201910136R A SG11201910136R A SG 11201910136RA
- Authority
- SG
- Singapore
- Prior art keywords
- san diego
- international
- california
- nexus
- drive
- Prior art date
Links
- 239000008123 high-intensity sweetener Substances 0.000 title abstract 2
- 235000013615 non-nutritive sweetener Nutrition 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229930189775 mogroside Natural products 0.000 abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229940125904 compound 1 Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- -1 Compound 1 Chemical class 0.000 abstract 1
- 108030005251 Cucurbitadienol synthases Proteins 0.000 abstract 1
- 102220547770 Inducible T-cell costimulator_A23L_mutation Human genes 0.000 abstract 1
- 241000428199 Mustelinae Species 0.000 abstract 1
- 239000013592 cell lysate Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/14—Yeasts or derivatives thereof
- A23L33/145—Extracts
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/33—Artificial sweetening agents containing sugars or derivatives
- A23L27/36—Terpene glycosides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/244—Endo-1,3(4)-beta-glucanase (3.2.1.6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/12—Acting on D ring
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/20—Preparation of steroids containing heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/02—Oxidoreductases acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
- C12Y106/02004—NADPH-hemoprotein reductase (1.6.2.4), i.e. NADP-cytochrome P450-reductase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01006—Endo-1,3(4)-beta-glucanase (3.2.1.6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y504/00—Intramolecular transferases (5.4)
- C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
- C12Y504/99003—2-Acetolactate mutase (5.4.99.3)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Seasonings (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
1050_ YPD_ Mog5Opct_ 7mg_ ml_ Day2 5.0 1.91 _ 2 ' 13 2.43 MogV MogIllE 3.40 2 . 89 3.0 7 / 3.56 3.28 3.94 0.29 2.00 2.20 2.40 2.60 2.80 3.00 3.20 3.40 3.60 3.80 4.00 4.20 4.40 4.60 4.80 5.00 MogIllE Compoundl- \ 2.85 1.31 1.26 1.97 0.0 - a 0 1250.000 - .T73 1000.000 - 750.000 - 0 - 1 500.000 - >. 250.000 - c.9 0.000 1.21 0.05 0.01 .82 1 91 . 2.05 2 54 . 2.12 2.61 3.43 2.96) 3.93 5.30 3 . 63 4.06 4 . 13 5.40 4.56 4 . 69 Range: 1760 *!IC cc 00 O O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT omit VIII °nolo III olo Imo mil mil onoilloo# (10) International Publication Number WO 2018/204483 A3 (51) International Patent Classification: C12P 33/12 (2006.01) A23L 27/20 (2016.01) C12N 15/52 (2006.01) (21) International Application Number: PCT/US2018/030627 (22) International Filing Date: 02 May 2018 (02.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/501,018 03 May 2017 (03.05.2017) US 62/551,750 29 August 2017 (29.08.2017) US (71) Applicant: SENOMYX, INC. [US/US]; 4767 Nexus Cen- tre Drive, San Diego, California 92121 (US). (72) Inventors: PATRON, Andrew, P.; 4767 Nexus Centre Drive, San Diego, California 92121 (US). NORIEGA, Chris, Edano; 4767 Nexus Centre Drive, San Diego, Cali- fornia 92121 (US). MANAM, Rama, R.; 4767 Nexus Cen- tre Drive, San Diego, California 92121 (US). COLQUITT, Justin; 4767 Nexus Centre Drive, San Diego, California 92121 (US). FABER, Nathan; 4473 Alabama Apt. 16, San Diego, California 92116 (US). ZIELER, Helge; 1155 Camino Del Mar #148, Del Mar, California 92014 (US). STEGE, Justin; 11355 Dennig Place, San Diego, Califor- nia 92126 (US). (74) Agent: LIU, Jing; KNOBBE, MARTENS, OLSON & BEAR, LLP, 2040 Main Street, 14th Floor, Irvine, Califor- nia 92614 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: METHODS FOR MAKING HIGH INTENSITY SWEETENERS 3. Dode Airy Range: 6.684 0.00 0.50 1.00 1.50 2.00 2.50 3.00 3.50 4.00 4.50 5.00 5.50 6.00 FIG. 37 (57) : Provided herein include methods of making mogroside compounds, e.g., Compound 1, compositions (for example host cells) for making the mogroside compounds, and the mogroside compounds made by the methods disclosed herein, and compositions (for example, cell lysates) and recombinant cells comprising the mogroside compounds (e.g., Compound 1). Also provided herein are novel cucurbitadienol synthases and the use thereof. [Continued on next page] WO 2018/204483 A3 MIDEDIMOMOIDEIRDERIHIMINHOIHNOMEMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 20 December 2018 (20.12.2018)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201762501018P | 2017-05-03 | 2017-05-03 | |
US201762551750P | 2017-08-29 | 2017-08-29 | |
PCT/US2018/030627 WO2018204483A2 (en) | 2017-05-03 | 2018-05-02 | Methods for making high intensity sweeteners |
Publications (1)
Publication Number | Publication Date |
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SG11201910136RA true SG11201910136RA (en) | 2019-11-28 |
Family
ID=64016614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201910136R SG11201910136RA (en) | 2017-05-03 | 2018-05-02 | Methods for making high intensity sweeteners |
Country Status (11)
Country | Link |
---|---|
US (2) | US11060124B2 (en) |
EP (1) | EP3615679A4 (en) |
JP (2) | JP7285786B2 (en) |
CN (1) | CN111108213A (en) |
BR (1) | BR112019023104A2 (en) |
MX (2) | MX2019012940A (en) |
PH (1) | PH12019502456A1 (en) |
RU (1) | RU2767792C2 (en) |
SG (1) | SG11201910136RA (en) |
TW (1) | TW201843304A (en) |
WO (1) | WO2018204483A2 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3368542B1 (en) | 2015-10-29 | 2022-06-22 | Firmenich Incorporated | High intensity sweeteners |
GB201805576D0 (en) * | 2018-04-04 | 2018-05-16 | Optibiotix Ltd | Sweeteners and methods of production thereof |
EP3860363A1 (en) * | 2018-11-07 | 2021-08-11 | Firmenich Incorporated | Methods for making high intensity sweeteners |
US20240218402A1 (en) * | 2018-11-07 | 2024-07-04 | Firmenich Incorporated | Methods for making high intensity sweeteners |
CA3118924A1 (en) * | 2018-11-09 | 2020-05-14 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
BR112021016964A8 (en) * | 2019-02-26 | 2021-12-14 | Coca Cola Co | Mogroside biocatalysis methods |
EP3947701A1 (en) | 2019-04-02 | 2022-02-09 | Novozymes A/S | Process for producing a fermentation product |
WO2020200916A1 (en) * | 2019-04-04 | 2020-10-08 | Firmenich Sa | Mogroside compounds and uses thereof |
CN110669094B (en) * | 2019-10-14 | 2021-12-21 | 上海交通大学 | New mogroside and its prepn |
US20220378072A1 (en) * | 2019-10-25 | 2022-12-01 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
CN110726787B (en) * | 2019-11-11 | 2022-10-11 | 广西中烟工业有限责任公司 | LC-MS/MS negative ion mode detection method for analyzing seven mogrosides |
CN110669809B (en) * | 2019-11-12 | 2022-12-23 | 广西师范大学 | Method for preparing mogroside IV and mogroside V by enzyme method |
CN113106114B (en) * | 2020-01-13 | 2024-04-12 | 中国科学院分子植物科学卓越创新中心 | Factor for regulating expression efficiency of trichoderma reesei protein, regulating method and application |
EP4048086A1 (en) * | 2020-03-05 | 2022-08-31 | Firmenich SA | 11-oxo-cucurbitanes and their use as flavor modifiers |
CN115605081A (en) * | 2020-03-17 | 2023-01-13 | 可口可乐公司(Us) | Novel mogroside production system and method |
US20230174993A1 (en) * | 2020-05-13 | 2023-06-08 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
CN112626094A (en) * | 2021-01-15 | 2021-04-09 | 中国水产科学研究院黄海水产研究所 | Gene, amino acid sequence and application of cyclodextrin glucosyltransferase |
CN113429451B (en) * | 2021-05-31 | 2022-02-08 | 湖南华诚生物资源股份有限公司 | Momordica grosvenori acid acylation derivative and preparation method thereof |
WO2023278226A1 (en) * | 2021-06-29 | 2023-01-05 | Firmenich Incorporated | Mogroside compounds and their comestible use |
CN113481275A (en) * | 2021-07-23 | 2021-10-08 | 湖南华诚生物资源股份有限公司 | Method for preparing mogroside through enzyme catalysis semisynthesis |
CN113584110A (en) * | 2021-08-11 | 2021-11-02 | 河北维达康生物科技有限公司 | Construction and application of engineering strain for biosynthesizing mogroside V by taking mogrol as substrate |
CN114946910A (en) * | 2022-03-31 | 2022-08-30 | 广西朗盛食品科技有限公司 | Low-sugar red bean and yolk crisp cake and preparation method thereof |
WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
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-
2018
- 2018-05-02 SG SG11201910136R patent/SG11201910136RA/en unknown
- 2018-05-02 CN CN201880044909.3A patent/CN111108213A/en active Pending
- 2018-05-02 MX MX2019012940A patent/MX2019012940A/en unknown
- 2018-05-02 JP JP2019560352A patent/JP7285786B2/en active Active
- 2018-05-02 US US15/969,616 patent/US11060124B2/en active Active
- 2018-05-02 RU RU2019138986A patent/RU2767792C2/en active
- 2018-05-02 BR BR112019023104-8A patent/BR112019023104A2/en unknown
- 2018-05-02 WO PCT/US2018/030627 patent/WO2018204483A2/en active Search and Examination
- 2018-05-02 EP EP18794373.3A patent/EP3615679A4/en active Pending
- 2018-05-03 TW TW107115087A patent/TW201843304A/en unknown
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2019
- 2019-10-30 MX MX2023003744A patent/MX2023003744A/en unknown
- 2019-10-30 PH PH12019502456A patent/PH12019502456A1/en unknown
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2021
- 2021-06-23 US US17/355,912 patent/US20210324439A1/en active Pending
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EP3615679A2 (en) | 2020-03-04 |
RU2767792C2 (en) | 2022-03-21 |
JP2020518264A (en) | 2020-06-25 |
TW201843304A (en) | 2018-12-16 |
PH12019502456A1 (en) | 2020-07-20 |
RU2019138986A3 (en) | 2021-06-03 |
MX2019012940A (en) | 2019-12-16 |
US11060124B2 (en) | 2021-07-13 |
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BR112019023104A2 (en) | 2020-11-03 |
RU2019138986A (en) | 2021-06-03 |
EP3615679A4 (en) | 2021-02-17 |
US20210324439A1 (en) | 2021-10-21 |
US20190071705A1 (en) | 2019-03-07 |
JP7285786B2 (en) | 2023-06-02 |
WO2018204483A2 (en) | 2018-11-08 |
JP2023052703A (en) | 2023-04-11 |
CN111108213A (en) | 2020-05-05 |
WO2018204483A3 (en) | 2018-12-20 |
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