MX2016007671A - Metodo para producir celulas del epitelio pigmentario retiniano. - Google Patents

Metodo para producir celulas del epitelio pigmentario retiniano.

Info

Publication number
MX2016007671A
MX2016007671A MX2016007671A MX2016007671A MX2016007671A MX 2016007671 A MX2016007671 A MX 2016007671A MX 2016007671 A MX2016007671 A MX 2016007671A MX 2016007671 A MX2016007671 A MX 2016007671A MX 2016007671 A MX2016007671 A MX 2016007671A
Authority
MX
Mexico
Prior art keywords
epithelial cells
retinal pigment
pigment epithelial
producing retinal
producing
Prior art date
Application number
MX2016007671A
Other languages
English (en)
Inventor
Choudhary Parul
Surmacz-Cordle Beata
Dawn Ellen BOOTH Heather
John Whiting Paul
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of MX2016007671A publication Critical patent/MX2016007671A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0621Eye cells, e.g. cornea, iris pigmented cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/15Transforming growth factor beta (TGF-β)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/155Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/16Activin; Inhibin; Mullerian inhibiting substance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/52Fibronectin; Laminin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/90Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La invención se refiere a un método para producir células del epitelio pigmentario retiniano.
MX2016007671A 2013-12-11 2014-12-08 Metodo para producir celulas del epitelio pigmentario retiniano. MX2016007671A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361914445P 2013-12-11 2013-12-11
PCT/IB2014/066703 WO2015087231A1 (en) 2013-12-11 2014-12-08 Method for producing retinal pigment epithelial cells

Publications (1)

Publication Number Publication Date
MX2016007671A true MX2016007671A (es) 2016-10-14

Family

ID=52446403

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016007671A MX2016007671A (es) 2013-12-11 2014-12-08 Metodo para producir celulas del epitelio pigmentario retiniano.

Country Status (13)

Country Link
EP (1) EP3080248A1 (es)
JP (1) JP2017504311A (es)
KR (1) KR101871084B1 (es)
CN (1) CN105814194A (es)
AR (1) AR098693A1 (es)
AU (1) AU2014363032A1 (es)
BR (1) BR112016012129A8 (es)
CA (1) CA2933083A1 (es)
HK (1) HK1221734A1 (es)
IL (1) IL245594A0 (es)
MX (1) MX2016007671A (es)
TW (2) TW201538726A (es)
WO (1) WO2015087231A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016081364A1 (en) * 2014-11-21 2016-05-26 Rigel Pharmaceuticals, Inc. Fused imidazole derivatives as tgf-beta inhibitors
CA2972700A1 (en) * 2014-12-30 2016-07-07 Cell Cure Neurosciences Ltd. Methods of treating retinal diseases
MX2017008737A (es) * 2014-12-30 2018-01-25 Cell Cure Neurosciences Ltd Poblaciones de celulas rpe y metodos para generar las mismas.
EP3916085A1 (en) * 2014-12-30 2021-12-01 Cell Cure Neurosciences Ltd. Assessing retinal pigment epithelial cell populations
DK3331994T3 (da) 2015-08-05 2022-11-21 Cell Cure Neurosciences Ltd Fremstilling af retinale pigmentepitelceller
EP4001402A1 (en) * 2015-09-08 2022-05-25 FUJIFILM Cellular Dynamics, Inc. Macs-based purification of stem cell-derived retinal pigment epithelium
AU2016321170B2 (en) * 2015-09-08 2022-09-01 Fujifilm Cellular Dynamics Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells
CA3002157A1 (en) 2015-10-20 2017-04-27 FUJIFILM Cellular Dynamics, Inc. Methods for directed differentiation of pluripotent stem cells to immune cells
WO2017091844A1 (en) * 2015-12-04 2017-06-08 Bond University Ltd Methods of differentiating retinal cells
CN106344932B (zh) * 2016-08-26 2019-12-27 首都医科大学附属北京同仁医院 一种用于提高视网膜退行性疾病基因治疗效果的组合物及其应用
WO2018106414A1 (en) 2016-12-07 2018-06-14 Mayo Foundation For Medical Education And Research Methods and materials for using fibrin supports for retinal pigment epithelium transplantation
CN106906178A (zh) * 2017-04-07 2017-06-30 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 培养上皮细胞的组合物及其保持上皮样细胞形态中的应用
ES2912383T3 (es) 2017-04-18 2022-05-25 Fujifilm Cellular Dynamics Inc Células efectoras inmunitarias específicas de antígeno
MX2019014503A (es) * 2017-06-05 2020-01-23 Mayo Found Medical Education & Res Metodos y materiales para cultivar, proliferar, y diferenciar celulas madre.
CN109957545A (zh) 2017-12-26 2019-07-02 江苏艾尔康生物医药科技有限公司 一种消化rpe细胞的方法
WO2020003219A1 (en) * 2018-06-29 2020-01-02 Oat & Iil India Laboratories Private Limited Substituted pyrazole derivatives as insecticides and fungicides
US20220259558A1 (en) * 2019-05-15 2022-08-18 Novo Nordisk A/S Methods for obtaining eye field progenitor cells from human pluripotent stem cells
EP4001425A4 (en) * 2019-07-19 2023-04-19 Tokyo Electron Limited METHODS OF EVALUATION OF THE STATUS OF CELL DIFFERENTIATION
WO2021020282A1 (ja) 2019-07-26 2021-02-04 学校法人埼玉医科大学 Alk2/acvr1の細胞外領域を認識する抗体
CN113699097B (zh) * 2021-09-08 2023-06-09 湖南光琇高新生命科技有限公司 视网膜色素上皮细胞的制备方法
CN120905148B (zh) * 2025-10-11 2026-01-06 中国人民解放军陆军军医大学第一附属医院 一种基于ChR2和GCaMP5G双转染hESC构建起搏细胞制备视网膜类器官的方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG49267A1 (en) 1989-08-14 1998-05-18 Photogenesis Inc Surgical instrument and cell isolation and transplantation
US6045791A (en) 1992-03-06 2000-04-04 Photogenesis, Inc. Retinal pigment epithelium transplantation
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5941250A (en) 1996-11-21 1999-08-24 University Of Louisville Research Foundation Inc. Retinal tissue implantation method
JP2006501848A (ja) 2002-10-04 2006-01-19 ティシュテク,インク. 網膜色素上皮細胞の羊膜での培養及び移植
EP2438814A3 (en) 2004-01-23 2012-10-03 Advanced Cell Technology, Inc. Improved modalities for the treatment of degenerative diseases of the retina
WO2006052646A2 (en) 2004-11-04 2006-05-18 Advanced Cell Technology, Inc. Derivation of embryonic stem cells
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
CN101356270B (zh) 2005-12-13 2014-02-12 国立大学法人京都大学 核重新编程因子
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US20090227032A1 (en) 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
EP2128244A4 (en) 2007-01-18 2012-05-09 Riken PROCESS FOR INDUCTION / DIFFERENTIATION TO A PHOTOREZEPTORZELLE
AU2008231020B2 (en) 2007-03-23 2013-09-05 Wisconsin Alumni Research Foundation Somatic cell reprogramming
WO2008129554A1 (en) 2007-04-18 2008-10-30 Hadasit Medical Research Services & Development Limited Stem cell-derived retinal pigment epithelial cells
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
DK2209888T3 (da) 2007-10-12 2020-01-20 Astellas Inst For Regenerative Medicine Forbedrede fremgangsmåder til fremstilling af rpe-celler og sammensætninger af rpe-celler
GB0806746D0 (en) 2008-04-14 2008-05-14 Ucl Business Plc Membrane
WO2011028524A1 (en) 2009-08-24 2011-03-10 Wisconsin Alumni Research Foundation Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
KR20120102709A (ko) 2009-11-17 2012-09-18 어드밴스드 셀 테크놀로지, 인코포레이티드 인간 rpe 세포의 생산 방법 및 인간 rpe 세포의 제약 제제
EP2383333B1 (en) 2010-04-28 2015-05-27 Technische Universität Dresden Method for producing polarized retinal progenitor cells from pluripotent stem cells and their differentiation into retinal pigment epithelium cells
PT2577318T (pt) * 2010-05-25 2019-10-14 Memorial Sloan Kettering Cancer Center Método de diferenciação de nocicetor de células estaminais embrionárias humanas e utilizações do mesmo
GB201011313D0 (en) 2010-07-05 2010-08-18 Ucl Business Plc Implantation devices, methods and implants
AU2011279250B2 (en) 2010-07-12 2014-12-04 California Institute Of Technology Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same
US8871744B2 (en) 2010-07-21 2014-10-28 B & G Partyers, LLC Compounds and methods for selectively targeting tumor-associated mucins
CN102465111A (zh) * 2010-11-19 2012-05-23 薛志刚 一种体外人胚胎干细胞诱导分化为视网膜色素上皮细胞的试验方法
RU2590864C2 (ru) 2011-01-18 2016-07-10 МИНИПАМПЗ, ЭлЭлСи Хирургический инструмент для имплантации
WO2012177968A1 (en) 2011-06-22 2012-12-27 The Schepens Eye Research Institute, Inc. A scaffold for subretinal cell transplantation and drug delivery
TW202434266A (zh) 2011-11-14 2024-09-01 安斯泰來再生醫藥協會 人類rpe細胞之醫藥組合物及其用途
US9850463B2 (en) 2012-02-01 2017-12-26 The Regents Of The University Of California Methods of culturing retinal pigmented epithelium cells, including xeno-free production, RPE enrichment, and cryopreservation
CN102618488A (zh) * 2012-03-15 2012-08-01 中国人民解放军第三军医大学第一附属医院 一种制备视网膜色素上皮细胞的方法
WO2013184809A1 (en) 2012-06-05 2013-12-12 The Regents Of The University Of California Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells
EP3323884A1 (en) 2013-02-01 2018-05-23 The United States Of America as Represented by the Secretary, Department of Health an Human Service Method for generating retinal pigment epithelium (rpe) cells from induced pluripotent stem cells (ipscs)

Also Published As

Publication number Publication date
AR098693A1 (es) 2016-06-08
IL245594A0 (en) 2016-06-30
AU2014363032A1 (en) 2016-06-09
EP3080248A1 (en) 2016-10-19
JP2017504311A (ja) 2017-02-09
KR101871084B1 (ko) 2018-06-25
TW201538726A (zh) 2015-10-16
KR20160095118A (ko) 2016-08-10
HK1221734A1 (zh) 2017-06-09
BR112016012129A8 (pt) 2020-05-12
CA2933083A1 (en) 2015-06-18
BR112016012129A2 (pt) 2017-08-08
TW201823451A (zh) 2018-07-01
WO2015087231A1 (en) 2015-06-18
CN105814194A (zh) 2016-07-27

Similar Documents

Publication Publication Date Title
MX2016007671A (es) Metodo para producir celulas del epitelio pigmentario retiniano.
IL257794A (en) A method for producing retinal pigment epithelial cells
EP3070162A4 (en) Method for producing retinal pigment epithelial cells
EP3006622A4 (en) Production method for fine-fibre-containing sheet
MX2015002487A (es) Proceso para la preparacion de teneligliptina.
EP2978733A4 (en) INTEGRATED METHOD FOR INCREASING BUTADIA PRODUCTION
EP3073392A4 (en) Database implementation method
EP3042960A4 (en) Method for producing ambrein
EP3037407A4 (en) Method for producing 1,5-pentadiamine
EP3048094A4 (en) Bis(amino-methyl)cyclohexane production method
MX379427B (es) Proceso para la preparación de 4-hidroxi-4-metiltetrahidropiranos 2-sustituidos en una cascada de reactores.
EP3056094A4 (en) Method for producing fried-noodle cluster
GB201715167D0 (en) Methods for hydrogen production
SG11201507951SA (en) Method for producing 2,7-octadien-1-ol
MX376491B (es) Metodo para producir 4-hidroxi-4-metil-tetrahidropiranos 2-sustituidos, donde dicho proceso usa reciclado.
PL3042880T3 (pl) Sposób wytwarzania płyty szklanej
EP2995702A4 (en) Zinc production method
MY167584A (en) Method for producing ethanol
EP3061352A4 (en) Method for producing kakiage
SG11201506828WA (en) Process for producing butadiene
EP3045437A4 (en) Method for producing butadiene
SG11201610165SA (en) Electrocatalyst for hydrogen production
EP3042888A4 (en) Method for producing 1,1-dibromo-1-fluoroethane
EP3067427A4 (en) Production method for fructooligosaccharide
PL3087162T3 (pl) Sposób wytwarzania średnich destylatów