BR112016012129A8 - métodos para produção, expansão e purificação de células epiteliais do pigmento da retina, composição farmacêutica e uso das células - Google Patents

métodos para produção, expansão e purificação de células epiteliais do pigmento da retina, composição farmacêutica e uso das células Download PDF

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Publication number
BR112016012129A8
BR112016012129A8 BR112016012129A BR112016012129A BR112016012129A8 BR 112016012129 A8 BR112016012129 A8 BR 112016012129A8 BR 112016012129 A BR112016012129 A BR 112016012129A BR 112016012129 A BR112016012129 A BR 112016012129A BR 112016012129 A8 BR112016012129 A8 BR 112016012129A8
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BR
Brazil
Prior art keywords
cells
purification
expansion
production
methods
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BR112016012129A
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English (en)
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BR112016012129A2 (pt
Inventor
Surmacz-Cordle Beata
Dawn Ellen BOOTH Heather
Choudhary Parul
John Whiting Paul
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Pfizer Ltd
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Publication of BR112016012129A2 publication Critical patent/BR112016012129A2/pt
Publication of BR112016012129A8 publication Critical patent/BR112016012129A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Abstract

a presente invenção refere-se a um método para produzir células epiteliais do pigmento da retina.
BR112016012129A 2013-12-11 2014-12-08 métodos para produção, expansão e purificação de células epiteliais do pigmento da retina, composição farmacêutica e uso das células BR112016012129A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361914445P 2013-12-11 2013-12-11
PCT/IB2014/066703 WO2015087231A1 (en) 2013-12-11 2014-12-08 Method for producing retinal pigment epithelial cells

Publications (2)

Publication Number Publication Date
BR112016012129A2 BR112016012129A2 (pt) 2017-08-08
BR112016012129A8 true BR112016012129A8 (pt) 2020-05-12

Family

ID=52446403

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016012129A BR112016012129A8 (pt) 2013-12-11 2014-12-08 métodos para produção, expansão e purificação de células epiteliais do pigmento da retina, composição farmacêutica e uso das células

Country Status (13)

Country Link
EP (1) EP3080248A1 (pt)
JP (1) JP2017504311A (pt)
KR (1) KR101871084B1 (pt)
CN (1) CN105814194A (pt)
AR (1) AR098693A1 (pt)
AU (1) AU2014363032A1 (pt)
BR (1) BR112016012129A8 (pt)
CA (1) CA2933083A1 (pt)
HK (1) HK1221734A1 (pt)
IL (1) IL245594A0 (pt)
MX (1) MX2016007671A (pt)
TW (2) TW201538726A (pt)
WO (1) WO2015087231A1 (pt)

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US20180008458A1 (en) * 2014-12-30 2018-01-11 Cell Cure Neurosciences Ltd. Methods of treating retinal diseases
ES2880346T3 (es) * 2014-12-30 2021-11-24 Cell Cure Neurosciences Ltd Evaluación de poblaciones de células epiteliales de pigmento retiniano
US11891622B2 (en) * 2014-12-30 2024-02-06 Cell Cure Neurosciences Ltd. RPE cell populations and methods of generating same
DK3331994T3 (da) 2015-08-05 2022-11-21 Cell Cure Neurosciences Ltd Fremstilling af retinale pigmentepitelceller
ES2903442T3 (es) * 2015-09-08 2022-04-01 Fujifilm Cellular Dynamics Inc Purificación basada en MACS del epitelio pigmentario de la retina derivado de células madre
US20190169569A1 (en) * 2015-09-08 2019-06-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells
WO2017070337A1 (en) 2015-10-20 2017-04-27 Cellular Dynamics International, Inc. Methods for directed differentiation of pluripotent stem cells to immune cells
EP3384008A4 (en) * 2015-12-04 2019-10-02 Bond University Ltd METHODS OF DIFFERENTIATING RETINAL CELLS
CN106344932B (zh) * 2016-08-26 2019-12-27 首都医科大学附属北京同仁医院 一种用于提高视网膜退行性疾病基因治疗效果的组合物及其应用
CA3045464C (en) 2016-12-07 2023-10-17 Mayo Foundation For Medical Education And Research Methods and materials for using fibrin supports for retinal pigment epithelium transplantation
CN106906178A (zh) * 2017-04-07 2017-06-30 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 培养上皮细胞的组合物及其保持上皮样细胞形态中的应用
EP3635094A4 (en) * 2017-06-05 2021-03-17 Mayo Foundation for Medical Education and Research PROCESSES AND MATERIALS FOR THE CULTURE, PROLIFERATION AND DIFFERENTIATION OF STEM CELLS
CN109957545A (zh) 2017-12-26 2019-07-02 江苏艾尔康生物医药科技有限公司 一种消化rpe细胞的方法
TW202012390A (zh) * 2018-06-29 2020-04-01 日商日本歐愛特農業科技股份有限公司 新穎之經取代吡唑衍生物
CN113811605A (zh) * 2019-05-15 2021-12-17 诺和诺德股份有限公司 从人多能干细胞获得眼野祖细胞的方法
EP4001425A4 (en) * 2019-07-19 2023-04-19 Tokyo Electron Limited METHODS OF EVALUATION OF THE STATUS OF CELL DIFFERENTIATION
US20220267453A1 (en) 2019-07-26 2022-08-25 Saitama Medical University Antibody recognizing extracellular region of alk2/acvr1
CN113699097B (zh) * 2021-09-08 2023-06-09 湖南光琇高新生命科技有限公司 视网膜色素上皮细胞的制备方法

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Also Published As

Publication number Publication date
CN105814194A (zh) 2016-07-27
AU2014363032A1 (en) 2016-06-09
CA2933083A1 (en) 2015-06-18
WO2015087231A1 (en) 2015-06-18
JP2017504311A (ja) 2017-02-09
AR098693A1 (es) 2016-06-08
BR112016012129A2 (pt) 2017-08-08
HK1221734A1 (zh) 2017-06-09
EP3080248A1 (en) 2016-10-19
IL245594A0 (en) 2016-06-30
KR101871084B1 (ko) 2018-06-25
TW201823451A (zh) 2018-07-01
TW201538726A (zh) 2015-10-16
MX2016007671A (es) 2016-10-14
KR20160095118A (ko) 2016-08-10

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements