MX2017008737A - Poblaciones de celulas rpe y metodos para generar las mismas. - Google Patents

Poblaciones de celulas rpe y metodos para generar las mismas.

Info

Publication number
MX2017008737A
MX2017008737A MX2017008737A MX2017008737A MX2017008737A MX 2017008737 A MX2017008737 A MX 2017008737A MX 2017008737 A MX2017008737 A MX 2017008737A MX 2017008737 A MX2017008737 A MX 2017008737A MX 2017008737 A MX2017008737 A MX 2017008737A
Authority
MX
Mexico
Prior art keywords
methods
cell populations
generating same
rpe cell
cells
Prior art date
Application number
MX2017008737A
Other languages
English (en)
Inventor
BOHANA-KASHTAN Osnat
Wiser Ofer
Ann Rosenberg Belmaker Lior
Original Assignee
Cell Cure Neurosciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Cure Neurosciences Ltd filed Critical Cell Cure Neurosciences Ltd
Publication of MX2017008737A publication Critical patent/MX2017008737A/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Se describe una población de células RPE poligonales humanas. Al menos 95% de las células de la misma coexpresan proteína de premelanosoma (PMEL17) y proteína de unión de retinaldehído celular (CRALBP), en donde la resistencia eléctrica transepitelial de las células es mayor que 100 ohms. También se describen métodos para generar los mismos.
MX2017008737A 2014-12-30 2015-12-30 Poblaciones de celulas rpe y metodos para generar las mismas. MX2017008737A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462097753P 2014-12-30 2014-12-30
US201562116972P 2015-02-17 2015-02-17
US201562195309P 2015-07-22 2015-07-22
PCT/IL2015/051269 WO2016108239A1 (en) 2014-12-30 2015-12-30 Rpe cell populations and methods of generating same

Publications (1)

Publication Number Publication Date
MX2017008737A true MX2017008737A (es) 2018-01-25

Family

ID=55315463

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017008737A MX2017008737A (es) 2014-12-30 2015-12-30 Poblaciones de celulas rpe y metodos para generar las mismas.

Country Status (17)

Country Link
US (5) US11891622B2 (es)
EP (2) EP3240892B9 (es)
JP (3) JP6882981B2 (es)
KR (1) KR20170115514A (es)
CN (1) CN107406830A (es)
AU (2) AU2015373050B2 (es)
BR (1) BR112017014345A2 (es)
CA (1) CA2972575A1 (es)
DK (1) DK3240892T5 (es)
EA (1) EA201791416A1 (es)
ES (1) ES2774456T3 (es)
HK (1) HK1246348A1 (es)
IL (3) IL305070A (es)
MX (1) MX2017008737A (es)
PH (1) PH12017501218A1 (es)
SG (1) SG11201705379VA (es)
WO (1) WO2016108239A1 (es)

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IL305070A (en) 2023-10-01
JP2021072832A (ja) 2021-05-13
EP3674397A1 (en) 2020-07-01
HK1246348A1 (zh) 2018-09-07
US20220154141A1 (en) 2022-05-19
BR112017014345A2 (pt) 2018-01-02
JP6882981B2 (ja) 2021-06-02
AU2015373050A9 (en) 2017-09-07
WO2016108239A9 (en) 2017-08-10
ES2774456T3 (es) 2020-07-21
EP3240892A1 (en) 2017-11-08
IL253238B (en) 2020-04-30
US20180016553A1 (en) 2018-01-18
ES2774456T9 (es) 2020-11-05
AU2015373050A1 (en) 2017-07-13
US20220169982A1 (en) 2022-06-02
CN107406830A (zh) 2017-11-28
JP2018502576A (ja) 2018-02-01
US20210332325A1 (en) 2021-10-28
IL273405A (en) 2020-05-31
EP3240892B1 (en) 2019-11-06
US11987810B2 (en) 2024-05-21
US20220169981A1 (en) 2022-06-02
PH12017501218A1 (en) 2018-01-29
EP3240892B9 (en) 2020-07-22
AU2022291539A1 (en) 2023-02-02
KR20170115514A (ko) 2017-10-17
DK3240892T5 (da) 2020-10-19
DK3240892T3 (da) 2020-02-17
US11891622B2 (en) 2024-02-06
IL273405B2 (en) 2024-01-01
WO2016108239A1 (en) 2016-07-07
JP2023052646A (ja) 2023-04-11
AU2015373050B2 (en) 2022-09-29
SG11201705379VA (en) 2017-08-30
CA2972575A1 (en) 2016-07-07
IL273405B1 (en) 2023-09-01
EA201791416A1 (ru) 2017-11-30
IL253238A0 (en) 2017-08-31

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