BR112017014345A2 - populações de células do rpe e métodos de gerar as mesmas - Google Patents

populações de células do rpe e métodos de gerar as mesmas

Info

Publication number
BR112017014345A2
BR112017014345A2 BR112017014345-3A BR112017014345A BR112017014345A2 BR 112017014345 A2 BR112017014345 A2 BR 112017014345A2 BR 112017014345 A BR112017014345 A BR 112017014345A BR 112017014345 A2 BR112017014345 A2 BR 112017014345A2
Authority
BR
Brazil
Prior art keywords
generating
methods
cell populations
rpe cell
cells
Prior art date
Application number
BR112017014345-3A
Other languages
English (en)
Inventor
BOHANA-KASHTAN Osnat
Ann Rosenberg Belmaker Lior
Wiser Ofer
Original Assignee
Cell Cure Neurosciences Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Cure Neurosciences Ltd. filed Critical Cell Cure Neurosciences Ltd.
Publication of BR112017014345A2 publication Critical patent/BR112017014345A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Abstract

uma população de células do rpe poligonais humanas é divulgada. pelo menos 95 % das células desta co-expressam premelano - alguma proteína (pmel17) e proteína de ligação de retinaldeído celular (cralbp), em que a resistência elétrica trans-epitelial das células é maior do que 100 ohms. métodos de gerar a mesma também são divulgados.
BR112017014345-3A 2014-12-30 2015-12-30 populações de células do rpe e métodos de gerar as mesmas BR112017014345A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462097753P 2014-12-30 2014-12-30
US62/097,753 2014-12-30
US201562116972P 2015-02-17 2015-02-17
US62/116,972 2015-02-17
US201562195309P 2015-07-22 2015-07-22
US62/195,309 2015-07-22
PCT/IL2015/051269 WO2016108239A1 (en) 2014-12-30 2015-12-30 Rpe cell populations and methods of generating same

Publications (1)

Publication Number Publication Date
BR112017014345A2 true BR112017014345A2 (pt) 2018-01-02

Family

ID=55315463

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017014345-3A BR112017014345A2 (pt) 2014-12-30 2015-12-30 populações de células do rpe e métodos de gerar as mesmas

Country Status (17)

Country Link
US (5) US11891622B2 (pt)
EP (2) EP3674397A1 (pt)
JP (3) JP6882981B2 (pt)
KR (1) KR20170115514A (pt)
CN (1) CN107406830A (pt)
AU (2) AU2015373050B2 (pt)
BR (1) BR112017014345A2 (pt)
CA (1) CA2972575A1 (pt)
DK (1) DK3240892T5 (pt)
EA (1) EA201791416A1 (pt)
ES (1) ES2774456T3 (pt)
HK (1) HK1246348A1 (pt)
IL (3) IL273405B2 (pt)
MX (1) MX2017008737A (pt)
PH (1) PH12017501218A1 (pt)
SG (1) SG11201705379VA (pt)
WO (1) WO2016108239A1 (pt)

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EP3240892B1 (en) 2019-11-06
EP3240892A1 (en) 2017-11-08
US20220169982A1 (en) 2022-06-02
WO2016108239A1 (en) 2016-07-07
JP2023052646A (ja) 2023-04-11
AU2022291539A1 (en) 2023-02-02
KR20170115514A (ko) 2017-10-17
US20220154141A1 (en) 2022-05-19
WO2016108239A9 (en) 2017-08-10
AU2015373050B2 (en) 2022-09-29
CA2972575A1 (en) 2016-07-07
US20210332325A1 (en) 2021-10-28
CN107406830A (zh) 2017-11-28
US11891622B2 (en) 2024-02-06
DK3240892T3 (da) 2020-02-17
PH12017501218A1 (en) 2018-01-29
EP3240892B9 (en) 2020-07-22
IL273405B1 (en) 2023-09-01
SG11201705379VA (en) 2017-08-30
US20220169981A1 (en) 2022-06-02
ES2774456T9 (es) 2020-11-05
JP2021072832A (ja) 2021-05-13
EP3674397A1 (en) 2020-07-01
HK1246348A1 (zh) 2018-09-07
IL273405A (en) 2020-05-31
IL253238B (en) 2020-04-30
JP6882981B2 (ja) 2021-06-02
ES2774456T3 (es) 2020-07-21
US20180016553A1 (en) 2018-01-18
EA201791416A1 (ru) 2017-11-30
AU2015373050A1 (en) 2017-07-13
IL305070A (en) 2023-10-01
DK3240892T5 (da) 2020-10-19
IL273405B2 (en) 2024-01-01
IL253238A0 (en) 2017-08-31
JP2018502576A (ja) 2018-02-01
MX2017008737A (es) 2018-01-25
AU2015373050A9 (en) 2017-09-07

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