PL2209888T3 - Ulepszony sposób wytwarzania komórek rpe i kompozycji komórek rpe - Google Patents

Ulepszony sposób wytwarzania komórek rpe i kompozycji komórek rpe

Info

Publication number
PL2209888T3
PL2209888T3 PL08839134T PL08839134T PL2209888T3 PL 2209888 T3 PL2209888 T3 PL 2209888T3 PL 08839134 T PL08839134 T PL 08839134T PL 08839134 T PL08839134 T PL 08839134T PL 2209888 T3 PL2209888 T3 PL 2209888T3
Authority
PL
Poland
Prior art keywords
cell
improved method
rpe
composition
cell composition
Prior art date
Application number
PL08839134T
Other languages
English (en)
Inventor
Christopher Malcuit
Linda Lemieux
Willliam Holmes
Pedro Huertas
Lucy Vilner
Original Assignee
Astellas Institute For Regenerative Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Institute For Regenerative Medicine filed Critical Astellas Institute For Regenerative Medicine
Publication of PL2209888T3 publication Critical patent/PL2209888T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/73—Hydrolases (EC 3.)
    • C12N2501/734—Proteases (EC 3.4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL08839134T 2007-10-12 2008-10-10 Ulepszony sposób wytwarzania komórek rpe i kompozycji komórek rpe PL2209888T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US99866807P 2007-10-12 2007-10-12
US99876607P 2007-10-12 2007-10-12
US991108P 2008-01-02 2008-01-02
US990808P 2008-01-02 2008-01-02
EP08839134.7A EP2209888B1 (en) 2007-10-12 2008-10-10 Improved methods of producing rpe cells and compositions of rpe cells
PCT/US2008/011669 WO2009051671A1 (en) 2007-10-12 2008-10-10 Improved methods of producing rpe cells and compositions of rpe cells

Publications (1)

Publication Number Publication Date
PL2209888T3 true PL2209888T3 (pl) 2020-05-18

Family

ID=40567677

Family Applications (1)

Application Number Title Priority Date Filing Date
PL08839134T PL2209888T3 (pl) 2007-10-12 2008-10-10 Ulepszony sposób wytwarzania komórek rpe i kompozycji komórek rpe

Country Status (13)

Country Link
US (4) US20110274662A1 (pl)
EP (2) EP2209888B1 (pl)
JP (6) JP2011500024A (pl)
KR (2) KR101849336B1 (pl)
CN (2) CN104946591A (pl)
AU (1) AU2008312007A1 (pl)
CA (3) CA3006687C (pl)
DK (1) DK2209888T3 (pl)
ES (1) ES2764473T3 (pl)
IL (4) IL292561A (pl)
PL (1) PL2209888T3 (pl)
PT (1) PT2209888T (pl)
WO (1) WO2009051671A1 (pl)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
AU2005207042B2 (en) * 2004-01-23 2010-09-09 President And Fellows Of Harvard College Improved modalities for the treatment of degenerative diseases of the retina
JP5441099B2 (ja) 2007-01-18 2014-03-12 独立行政法人理化学研究所 視細胞への分化誘導方法
CN104946591A (zh) 2007-10-12 2015-09-30 奥卡塔治疗公司 制备rpe 细胞和rpe 细胞的组合物的改良方法
WO2009132156A1 (en) * 2008-04-22 2009-10-29 Regenerative Research Foundation Retinal pigment epithelial stem cells
US10227563B2 (en) 2008-06-06 2019-03-12 Riken Method for culture of stem cell
WO2011025852A1 (en) * 2009-08-28 2011-03-03 Cellular Dynamics International, Inc. Identifying genetic variation in affected tissues
US10793830B2 (en) * 2009-11-05 2020-10-06 Riken Method for producing retinal tissue in vitro
EP2501802A4 (en) 2009-11-17 2013-08-21 Advanced Cell Tech Inc METHOD FOR PRODUCING HUMAN RPE CELLS AND PHARMACEUTICAL PREPARATIONS FROM HUMAN RPE CELLS
EP2509596B1 (en) 2009-12-08 2019-08-28 Case Western Reserve University Gamma aminoacids for treating ocular disorders
AU2011280878B2 (en) 2010-07-23 2016-06-16 Astellas Institute For Regenerative Medicine Methods for detection of rare subpopulations of cells and highly purified compositions of cells
FI20106354A0 (fi) * 2010-12-20 2010-12-20 Suomen Punainen Risti Veripalvelu Menetelmä ihmisen retinan pigmentti-epiteelisolujen valmistamiseksi
EP2709672B1 (en) 2011-05-18 2019-12-18 The Regents of The University of California Compositions and methods for treating retinal diseases
IL287381B2 (en) * 2011-11-14 2024-04-01 Astellas Inst For Regenerative Medicine Pharmaceutical preparations of human rpe cells and uses thereof
JP5985208B2 (ja) * 2011-11-25 2016-09-06 住友化学株式会社 網膜組織の製造方法
JP5985207B2 (ja) * 2011-11-25 2016-09-06 住友化学株式会社 網膜色素上皮細胞の製造方法
JP5985209B2 (ja) * 2011-11-25 2016-09-06 住友化学株式会社 眼杯様構造体の製造方法
JP6067232B2 (ja) * 2011-11-25 2017-01-25 住友化学株式会社 網膜層特異的神経細胞を製造する方法
US10973854B2 (en) 2011-11-25 2021-04-13 Sumitomo Chemical Company, Limited Methods for producing retinal tissue and retina-related cell
JP6012164B2 (ja) * 2011-11-25 2016-10-25 住友化学株式会社 多能性幹細胞由来の組織の凍結保存方法
RS57886B1 (sr) 2011-11-30 2019-01-31 Astellas Inst For Regenerative Medicine Mezenhimalne stromalne ćelije i primene vezane za njih
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
US10519422B2 (en) * 2012-02-29 2019-12-31 Riken Method of producing human retinal pigment epithelial cells
CA2876499C (en) 2012-07-12 2021-10-26 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
CN114558032B (zh) 2012-12-21 2025-07-29 安斯泰来再生医药协会 由多能干细胞制备血小板的方法及其组合物
EP2951290B1 (en) 2013-02-01 2017-11-29 The United States of America, as represented by The Secretary, Department of Health and Human Services Method for generating retinal pigment epithelium (rpe) cells from induced pluripotent stem cells (ipscs)
WO2014162040A1 (en) * 2013-04-03 2014-10-09 Tampereen Yliopisto Methods and media for differentiating eye cells
WO2015025967A1 (ja) 2013-08-23 2015-02-26 住友化学株式会社 網膜組織及び網膜関連細胞の製造方法
BR112016012129A8 (pt) 2013-12-11 2020-05-12 Pfizer Ltd métodos para produção, expansão e purificação de células epiteliais do pigmento da retina, composição farmacêutica e uso das células
JP6682446B2 (ja) 2014-10-24 2020-04-15 大日本住友製薬株式会社 網膜組織の製造方法
TWI810142B (zh) 2014-10-24 2023-08-01 日商住友製藥股份有限公司 神經組織的製造方法
JP6734853B2 (ja) * 2014-12-18 2020-08-05 ソルボンヌ・ユニヴェルシテＳｏｒｂｏｎｎｅ Ｕｎｉｖｅｒｓｉｔｅ 網膜変性処置のためのｏｔｘ２過剰発現トランスジェニック網膜色素上皮細胞
KR102514912B1 (ko) * 2014-12-30 2023-03-27 셀 큐어 뉴로사이언시스 리미티드 망막 질환의 치료 방법
IL305070B2 (en) 2014-12-30 2025-11-01 Cell Cure Neurosciences Ltd Rpe cell populations and methods of generating same
ES2980659T3 (es) 2015-03-23 2024-10-02 Astellas Inst For Regenerative Medicine Ensayos mejorados de potencia de células de epitelio pigmentario retiniano (EPR) humano y progenitores de fotorreceptores
SG10201913250SA (en) * 2015-08-18 2020-03-30 Astellas Inst For Regenerative Medicine Clinical formulations
KR102781602B1 (ko) 2015-09-08 2025-03-18 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 임상 등급 망막 색소 상피 세포의 재현성 있는 분화 방법
CA2997763A1 (en) * 2015-09-08 2017-03-16 Cellular Dynamics International, Inc. Macs-based purification of stem cell-derived retinal pigment epithelium
CA2998091C (en) 2015-09-08 2024-06-11 Sumitomo Dainippon Pharma Co., Ltd. Method for producing retinal tissue
ES2862676T3 (es) 2015-10-20 2021-10-07 Fujifilm Cellular Dynamics Inc Producción de células precursoras hematopoyéticas multilinaje mediante programación genética
HRP20250311T1 (hr) * 2015-10-26 2025-07-18 Cell Cure Neurosciences Ltd. Priprema stanica pigmentnog epitela mrežnice
EP3447129B1 (en) 2016-04-22 2022-07-20 Sumitomo Pharma Co., Ltd. Method for producing retinal tissue
WO2018003908A1 (ja) * 2016-06-30 2018-01-04 株式会社ヘリオス 移植用媒体
US20200087390A1 (en) 2016-12-21 2020-03-19 Amgen Inc. Anti-tnf alpha antibody formulations
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
AU2018254442B2 (en) 2017-04-18 2024-03-28 FUJIFILM Cellular Dynamics, Inc. Antigen-specific immune effector cells
JP7360583B2 (ja) 2017-09-14 2023-10-13 国立研究開発法人理化学研究所 網膜組織の製造方法
CN107760649B (zh) * 2017-11-02 2021-03-30 北京全式金生物技术有限公司 一种用于人神经系统细胞培养和人多能性干细胞向神经系统细胞分化的营养添加剂
CN111741735A (zh) 2017-12-29 2020-10-02 细胞治疗神经科学有限公司 视网膜色素上皮细胞组合物
KR102198942B1 (ko) * 2019-07-02 2021-01-05 의료법인 성광의료재단 Pedf를 발현하거나 모세포에 비하여 pedf를 과발현하도록 유전적으로 조작된 중간엽 줄기세포
JP7344421B2 (ja) * 2019-07-19 2023-09-14 東京エレクトロン株式会社 細胞の分化状態の評価方法
BR112022006644A2 (pt) * 2019-10-30 2022-07-12 Astellas Inst For Regenerative Medicine Métodos para a produção de células epiteliais de pigmento da retina
WO2022191216A1 (ja) 2021-03-09 2022-09-15 国立研究開発法人理化学研究所 低免疫原性網膜色素上皮細胞の製造方法
WO2023176906A1 (ja) 2022-03-16 2023-09-21 住友ファーマ株式会社 移植用媒体
KR20250007548A (ko) 2022-04-15 2025-01-14 아스펜 뉴로사이언스 인코포레이티드 세포의 분화 상태를 분류하는 방법 및 관련 분화된 세포 조성물
JPWO2024172043A1 (pl) 2023-02-14 2024-08-22
CN119020271B (zh) * 2024-07-17 2025-06-06 中国农业大学 一种提高卵子体外成熟质量及体外受精后胚胎妊娠率的组合物、方法及其应用

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610753A (en) 1991-12-12 1997-03-11 Eastman Kodak Company Optical design of laser scanner to reduce thermal sensitivity
EP0700429B1 (en) 1993-04-30 2000-10-11 PHOTOGENESIS Incorporated Retinal pigment epithelium transplantation
DE19609838A1 (de) 1996-03-13 1997-09-18 Boehringer Mannheim Gmbh Verfahren und Teststreifen zur Bestimmung eines Analyten
US6878544B2 (en) 1996-04-19 2005-04-12 Neurotech Sa Retinal cell lines with extended life-span and their applications
US20040086494A1 (en) 1996-10-07 2004-05-06 John Constance Mary Immune privileged cells for delivery of proteins and peptides
AU5734998A (en) * 1997-01-10 1998-08-03 Life Technologies, Inc. Embryonic stem cell serum replacement
US6331406B1 (en) 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
AU9040098A (en) 1997-09-10 1999-03-29 University Of Florida Compounds and method for the prevention and treatment of diabetic retinopathy
NZ505459A (en) 1998-01-02 2003-07-25 Titan Pharmaceuticals Inc Use of pigmented retinal epithelial cells for creation of an immune privilege site
AU2884499A (en) 1998-03-02 1999-09-20 Compucyte Corp. Selective cell analysis
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6943153B1 (en) 1999-03-15 2005-09-13 The Regents Of The University Of California Use of recombinant gene delivery vectors for treating or preventing diseases of the eye
US6331313B1 (en) 1999-10-22 2001-12-18 Oculex Pharmaceticals, Inc. Controlled-release biocompatible ocular drug delivery implant devices and methods
EP1230342A4 (en) 1999-10-28 2003-04-09 Univ Massachusetts GYNOGENETIC OR ANDROGENETIC PRODUCTION OF PLURIPOTENT CELLS AND CELL LINES AND THEIR USE IN THE PRODUCTION OF DIFFERENTIATED CELLS AND TISSUES
US20020035735A1 (en) 2000-01-07 2002-03-21 Gerald Schatten Clonal propagation of primate offspring by embryo splitting
US6602711B1 (en) 2000-02-21 2003-08-05 Wisconsin Alumni Research Foundation Method of making embryoid bodies from primate embryonic stem cells
US20030084471A1 (en) 2000-03-16 2003-05-01 David Beach Methods and compositions for RNA interference
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
CA2456008A1 (en) 2000-08-19 2002-02-28 Axordia Limited Stem cell differentiation
US6576464B2 (en) 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
AU2002236495B2 (en) 2000-11-29 2006-05-11 Allergan, Inc. Intraocular implants for preventing transplant rejection in the eye
DE10108412B4 (de) 2001-02-21 2006-03-09 Cevec Pharmaceuticals Gmbh Pigmentepithelzelle des Auges, ihre Herstellung und Verwendung in der Therapie einer Augen- oder Nervenerkrankung
JP2004531262A (ja) 2001-05-15 2004-10-14 ラッパポート ファミリー インスチチュート フォア リサーチ イン ザ メディカル サイエンシズ ヒト胚性幹細胞由来インスリン産生細胞
GB2393734B (en) 2001-07-12 2005-07-27 Geron Corp Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
MXPA04005010A (es) 2001-11-26 2005-04-08 Advanced Cell Tech Inc METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS.
CN101240262A (zh) 2001-12-07 2008-08-13 杰龙公司 源自人胚胎干细胞的胰岛细胞
AU2002366641A1 (en) 2001-12-11 2003-06-23 Fibrogen, Inc. Methods for inhibiting ocular processes
WO2003060083A2 (en) 2002-01-15 2003-07-24 Advanced Cell Technology, Inc. Cloning b and t lymphocytes
JP5578388B2 (ja) 2002-04-18 2014-08-27 オプコ ファーマシューティカルズ、エルエルシー 中枢神経システム及び／若しくは眼の細胞及び組織中の遺伝子の特異的阻害のための手段と方法
US20040091936A1 (en) 2002-05-24 2004-05-13 Michael West Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank
US7422736B2 (en) * 2002-07-26 2008-09-09 Food Industry Research And Development Institute Somatic pluripotent cells
JP2006501848A (ja) 2002-10-04 2006-01-19 ティシュテク，インク． 網膜色素上皮細胞の羊膜での培養及び移植
WO2004045374A2 (en) 2002-11-14 2004-06-03 Ethicon Endo-Surgery, Inc. Methods and devices for detecting tissue cells
US20040156878A1 (en) 2003-02-11 2004-08-12 Alireza Rezania Implantable medical device seeded with mammalian cells and methods of treatment
CA2518677A1 (en) 2003-03-03 2004-12-09 Nagaoka & Co., Ltd. Methods and apparatus for use in detection and quantitation of various cell types and use of optical bio-disc for performing same
EP1624751A2 (en) 2003-05-08 2006-02-15 Cellartis AB Cryopreservation of human blastocyst-derived stem cells by use of a closed straw vitrification method
KR100569168B1 (ko) 2003-08-08 2006-04-07 (주)아비코아생명공학연구소 조류 정원줄기세포의 배양방법 및 이에 의해 수득한 조류정원줄기세포
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
AU2005207042B2 (en) 2004-01-23 2010-09-09 President And Fellows Of Harvard College Improved modalities for the treatment of degenerative diseases of the retina
EP1743023A1 (en) 2004-05-07 2007-01-17 Wisconsin Alumni Research Foundation Method of forming mesenchymal stem cells from embryonic stem cells
US6945971B1 (en) 2004-07-19 2005-09-20 Gwon Arlene E Controlled ocular lens regeneration
WO2006040763A2 (en) 2004-10-12 2006-04-20 Technion Research & Development Foundation Ltd. Isolated primate embryonic cells and methods of generating and using same
US7893315B2 (en) 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
EP2960328A1 (en) 2004-11-04 2015-12-30 Ocata Therapeutics, Inc. Derivation of embryonic stem cells
DE602006016735D1 (de) 2005-02-11 2010-10-21 Agency Science Tech & Res Verfahren zur proliferation von stammzellen
WO2007020655A1 (en) 2005-05-17 2007-02-22 Reliance Life Sciences Pvt Ltd Establishment of a human embryonic stem cell line using mammalian cells
JP5006312B2 (ja) 2005-05-27 2012-08-22 エイジェンシー フォー サイエンス， テクノロジー アンド リサーチ バキュロウイルスベクターを使用して核酸分子を胚性幹細胞に送達する方法
US8198085B2 (en) 2005-08-03 2012-06-12 Core Dynamics Limited Somatic cells for use in cell therapy
JP4926615B2 (ja) 2006-08-29 2012-05-09 太陽化学株式会社 ガラクトマンナン酵素分解物の製造方法
KR100832592B1 (ko) 2006-08-17 2008-05-27 박현숙 폴리머 막을 이용한 줄기세포와 피더세포의 공배양방법
CN101563449A (zh) 2006-09-22 2009-10-21 理化学研究所 干细胞培养基及干细胞培养方法
US8956866B2 (en) * 2007-04-18 2015-02-17 Hadasit Medical Research Services And Development Ltd. Retinal pigment epithelial cells differentiated from embryonic stem cells with nicotinamide and activin A
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
CN104946591A (zh) 2007-10-12 2015-09-30 奥卡塔治疗公司 制备rpe 细胞和rpe 细胞的组合物的改良方法
HU0700675D0 (en) 2007-10-15 2007-12-28 Mta Tamogatott Kutatohelyek Ir Method for monitoring stem cell differentiation
US20090226955A1 (en) 2007-12-21 2009-09-10 University Of Miami Immortalized retinal pigmented epithelial cells
US20090233324A1 (en) 2008-03-11 2009-09-17 Kopf-Sill Anne R Methods for Diagnosing Cancer Using Samples Collected From A Central Vein Location or an Arterial Location
WO2009132156A1 (en) * 2008-04-22 2009-10-29 Regenerative Research Foundation Retinal pigment epithelial stem cells
US8652123B2 (en) 2008-09-02 2014-02-18 Geoffrey C. GURTNER Methods and devices for improving the appearance of tissue
EP2501802A4 (en) 2009-11-17 2013-08-21 Advanced Cell Tech Inc METHOD FOR PRODUCING HUMAN RPE CELLS AND PHARMACEUTICAL PREPARATIONS FROM HUMAN RPE CELLS
AU2011280878B2 (en) 2010-07-23 2016-06-16 Astellas Institute For Regenerative Medicine Methods for detection of rare subpopulations of cells and highly purified compositions of cells
WO2012149484A2 (en) 2011-04-29 2012-11-01 University Of Southern California Method of cryopreservation of stem cell-derived retinal pigment epithelial cells on polymeric substrate
IL287381B2 (en) 2011-11-14 2024-04-01 Astellas Inst For Regenerative Medicine Pharmaceutical preparations of human rpe cells and uses thereof
US9850463B2 (en) 2012-02-01 2017-12-26 The Regents Of The University Of California Methods of culturing retinal pigmented epithelium cells, including xeno-free production, RPE enrichment, and cryopreservation
ES2688019T3 (es) 2012-06-05 2018-10-30 The Regents Of The University Of California Métodos y composiciones para la producción acelerada de células epiteliales pigmentadas retinianas a partir de células pluripotentes

Also Published As

Publication number Publication date
US20220049217A1 (en) 2022-02-17
JP6692768B2 (ja) 2020-05-13
WO2009051671A1 (en) 2009-04-23
JP2014168482A (ja) 2014-09-18
JP2022079484A (ja) 2022-05-26
JP6137626B2 (ja) 2017-05-31
US20110274662A1 (en) 2011-11-10
KR20100065373A (ko) 2010-06-16
EP2209888B1 (en) 2019-12-04
ES2764473T3 (es) 2020-06-03
PT2209888T (pt) 2020-01-17
DK2209888T3 (da) 2020-01-20
JP2017136088A (ja) 2017-08-10
KR101849336B1 (ko) 2018-04-16
CA2702386C (en) 2018-07-24
US20190062703A1 (en) 2019-02-28
CN104946591A (zh) 2015-09-30
IL324350A (en) 2025-12-01
IL246181A0 (en) 2016-07-31
CA3006687A1 (en) 2009-04-23
KR101849329B1 (ko) 2018-04-16
KR20160045933A (ko) 2016-04-27
EP2209888A1 (en) 2010-07-28
CA3006687C (en) 2024-01-09
CA2702386A1 (en) 2009-04-23
CA3177952A1 (en) 2009-04-23
JP2011500024A (ja) 2011-01-06
IL292561A (en) 2022-06-01
US20150086512A1 (en) 2015-03-26
EP3636748A1 (en) 2020-04-15
AU2008312007A1 (en) 2009-04-23
JP2025036424A (ja) 2025-03-14
CN101878295A (zh) 2010-11-03
US10077424B2 (en) 2018-09-18
EP2209888A4 (en) 2011-02-09
IL204956A0 (en) 2010-11-30
IL204956A (en) 2016-06-30
JP2020115882A (ja) 2020-08-06

Similar Documents

Publication Publication Date Title
PT2209888T (pt) Métodos aperfeiçoados de produção de células rpe e composições de células rpe
IL252119B (en) Improved cell composition and methods of making the same
BRPI0920284A2 (pt) composição e método
DK2574677T3 (da) Fremgangsmåder til celledyrkning
PL2634243T3 (pl) Ulepszony sposób hodowli komórkowej
BRPI0921822A2 (pt) composição compreendendo polímero e enzima
PL2356462T3 (pl) Kompozycje anty-CXCR1 oraz sposoby
BRPI0919575A2 (pt) método, e, composição
SE0950586L (sv) Förbättrad odling av stamceller
DK3795573T3 (da) Bestemte triazolopyraziner, sammensætninger deraf og fremgangsmåder til anvendelse deraf
BRPI0906980A2 (pt) Composição de derivados e maleatados
BRPI0815407A2 (pt) Composições e métodos para controlar nematódeos
BRPI0823277A2 (pt) Composição, e , método
BRPI0810179A2 (pt) Composições de oligo-guluronato e galacturonato
BRPI0809573A2 (pt) composição, e, método
BRPI0815310A2 (pt) Composição adesiva, artigo e método de aplicação de uma composição adesiva
EP2079544A4 (en) ARSENIC ABSORBENT COMPOSITION AND METHODS OF USE
DK2240203T3 (da) Alfa5-beta1-antistoffer og deres anvendelser
FI20096058A0 (fi) Koostumuksia ja niihin liittyviä menetelmiä ja käyttöjä
EP2582664A4 (en) PHENYL THIOACETATE COMPOUNDS AND COMPOSITIONS AND METHOD FOR THEIR USE
BRPI0814167A2 (pt) Composição, e, método
PL2240018T3 (pl) Kompozycja zawierająca środek przeciwbólowy i przeciwhistaminowy
BRPI0820644A2 (pt) método de preparação de uma composição, e, composição
BRPI0823238A2 (pt) Composição, e, método
BR112012004668A2 (pt) "composição e processo"