EE200300360A - PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid - Google Patents

PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid

Info

Publication number
EE200300360A
EE200300360A EEP200300360A EEP200300360A EE200300360A EE 200300360 A EE200300360 A EE 200300360A EE P200300360 A EEP200300360 A EE P200300360A EE P200300360 A EEP200300360 A EE P200300360A EE 200300360 A EE200300360 A EE 200300360A
Authority
EE
Estonia
Prior art keywords
inhibitors
biaryl derivatives
pde4 isozymes
nicotinamide used
nicotinamide
Prior art date
Application number
EEP200300360A
Other languages
English (en)
Inventor
James Chambers Robert
Victor Magee Thomas
Marfat Anthony
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of EE200300360A publication Critical patent/EE200300360A/et

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
EEP200300360A 2001-01-31 2001-12-06 PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid EE200300360A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26549201P 2001-01-31 2001-01-31
PCT/IB2001/002341 WO2002060875A1 (en) 2001-01-31 2001-12-06 Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes

Publications (1)

Publication Number Publication Date
EE200300360A true EE200300360A (et) 2003-12-15

Family

ID=23010671

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200300360A EE200300360A (et) 2001-01-31 2001-12-06 PDE4 isosüümide inhibiitoritena kasutatavad nikotiinamiidi biarüülderivaadid

Country Status (25)

Country Link
US (2) US6649633B2 (et)
EP (1) EP1355884A1 (et)
JP (1) JP2004520386A (et)
KR (1) KR20030074761A (et)
CN (1) CN1518542A (et)
BG (1) BG108038A (et)
BR (1) BR0116852A (et)
CA (1) CA2436535A1 (et)
CR (1) CR7025A (et)
CZ (1) CZ20031895A3 (et)
EA (1) EA200300621A1 (et)
EC (2) ECSP034709A (et)
EE (1) EE200300360A (et)
HU (1) HUP0400637A2 (et)
IL (1) IL156413A0 (et)
IS (1) IS6846A (et)
MA (1) MA26983A1 (et)
MX (1) MXPA03006887A (et)
NO (1) NO20033397L (et)
NZ (1) NZ526453A (et)
OA (1) OA12540A (et)
PL (1) PL364135A1 (et)
SK (1) SK8792003A3 (et)
WO (1) WO2002060875A1 (et)
ZA (1) ZA200304894B (et)

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US6951869B2 (en) * 2002-02-26 2005-10-04 Schlesinger Stephen L Use of leukotriene receptor antagonist for treatment of scarring
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JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
KR20050115331A (ko) * 2003-04-01 2005-12-07 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 불임증 포스포디에스터라제의 억제제
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GB0317482D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
US7132435B2 (en) * 2003-07-25 2006-11-07 Pfizer Inc. Compounds
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GB0317498D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Compounds
GB0317516D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
GB0317484D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as pde4 inhibitors
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