IL156413A0 - Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes - Google Patents
Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymesInfo
- Publication number
- IL156413A0 IL156413A0 IL15641301A IL15641301A IL156413A0 IL 156413 A0 IL156413 A0 IL 156413A0 IL 15641301 A IL15641301 A IL 15641301A IL 15641301 A IL15641301 A IL 15641301A IL 156413 A0 IL156413 A0 IL 156413A0
- Authority
- IL
- Israel
- Prior art keywords
- nicotinamide
- inhibitors
- derivatives useful
- biaryl derivatives
- pde4 isozymes
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26549201P | 2001-01-31 | 2001-01-31 | |
PCT/IB2001/002341 WO2002060875A1 (en) | 2001-01-31 | 2001-12-06 | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
Publications (1)
Publication Number | Publication Date |
---|---|
IL156413A0 true IL156413A0 (en) | 2004-01-04 |
Family
ID=23010671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15641301A IL156413A0 (en) | 2001-01-31 | 2001-12-06 | Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes |
Country Status (25)
Country | Link |
---|---|
US (2) | US6649633B2 (xx) |
EP (1) | EP1355884A1 (xx) |
JP (1) | JP2004520386A (xx) |
KR (1) | KR20030074761A (xx) |
CN (1) | CN1518542A (xx) |
BG (1) | BG108038A (xx) |
BR (1) | BR0116852A (xx) |
CA (1) | CA2436535A1 (xx) |
CR (1) | CR7025A (xx) |
CZ (1) | CZ20031895A3 (xx) |
EA (1) | EA200300621A1 (xx) |
EC (2) | ECSP034709A (xx) |
EE (1) | EE200300360A (xx) |
HU (1) | HUP0400637A2 (xx) |
IL (1) | IL156413A0 (xx) |
IS (1) | IS6846A (xx) |
MA (1) | MA26983A1 (xx) |
MX (1) | MXPA03006887A (xx) |
NO (1) | NO20033397L (xx) |
NZ (1) | NZ526453A (xx) |
OA (1) | OA12540A (xx) |
PL (1) | PL364135A1 (xx) |
SK (1) | SK8792003A3 (xx) |
WO (1) | WO2002060875A1 (xx) |
ZA (1) | ZA200304894B (xx) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
JP4510384B2 (ja) * | 2001-05-23 | 2010-07-21 | 田辺三菱製薬株式会社 | 骨折治癒促進用組成物 |
JP4510383B2 (ja) * | 2001-05-23 | 2010-07-21 | 田辺三菱製薬株式会社 | 軟骨疾患修復治療用組成物 |
AU2002367730A1 (en) * | 2002-02-26 | 2003-09-09 | Stephen L. Schlesinger | Use of leukotriene receptor antagonist for treatment of scarring |
EP1424101A3 (en) * | 2002-11-29 | 2004-08-18 | NOZAKI, Masako | Use of a leukotriene C4 and D4 receptor antagonist for the preparation of a medicament for treating or preventing brain inflammation and sepsis |
AU2003300076C1 (en) | 2002-12-30 | 2010-03-04 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
EA200501548A1 (ru) * | 2003-04-01 | 2006-02-24 | Апплайд Резеч Системз Арс Холдинг Н.В. | Ингибиторы фосфодиэстераз при бесплодии |
GB0309781D0 (en) * | 2003-04-29 | 2003-06-04 | Glaxo Group Ltd | Compounds |
GB0317498D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Compounds |
GB0317482D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
US7132435B2 (en) * | 2003-07-25 | 2006-11-07 | Pfizer Inc. | Compounds |
US20050020587A1 (en) * | 2003-07-25 | 2005-01-27 | Pfizer Inc | Nicotinamide derivatives useful as PDE4 inhibitors |
US7153870B2 (en) | 2003-07-25 | 2006-12-26 | Pfizer Inc. | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317484D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
US20050154006A1 (en) * | 2004-01-09 | 2005-07-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions based on a scopineester and nicotinamide derivatives |
US20090042951A1 (en) * | 2004-02-20 | 2009-02-12 | Robert Danziger | Blood Pressure Reduction in Salt-Sensitive Hypertension |
WO2005087236A1 (en) * | 2004-03-11 | 2005-09-22 | Glaxo Group Limited | Novel m3 muscarinic acetylcholine receptor antagonists |
EP1745800A4 (en) * | 2004-04-26 | 2009-11-18 | Ono Pharmaceutical Co | NEW BLT2-MEDIATED DISEASE AND BLT2 BINDING AND CONNECTION |
US7704522B2 (en) * | 2004-09-08 | 2010-04-27 | Clyde Morgan | Topical medicament |
EP2410043A3 (en) | 2004-12-29 | 2013-01-23 | Hadasit Medical Research Services And Development Ltd. | Stem cells culture systems |
US8597947B2 (en) | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
EP1940389A2 (en) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
CN101355876B (zh) | 2005-11-09 | 2012-09-05 | 康宾纳特克斯公司 | 一种适用于眼部给药的组合物 |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
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- 2001-12-06 HU HU0400637A patent/HUP0400637A2/hu unknown
- 2001-12-06 EP EP01273556A patent/EP1355884A1/en not_active Withdrawn
- 2001-12-06 EA EA200300621A patent/EA200300621A1/ru unknown
- 2001-12-06 JP JP2002561026A patent/JP2004520386A/ja active Pending
- 2001-12-06 CZ CZ20031895A patent/CZ20031895A3/cs unknown
- 2001-12-06 WO PCT/IB2001/002341 patent/WO2002060875A1/en not_active Application Discontinuation
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- 2001-12-06 OA OA1200300175A patent/OA12540A/en unknown
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- 2001-12-06 PL PL01364135A patent/PL364135A1/xx not_active Application Discontinuation
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- 2001-12-06 SK SK879-2003A patent/SK8792003A3/sk not_active Application Discontinuation
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- 2001-12-06 KR KR10-2003-7010074A patent/KR20030074761A/ko not_active Application Discontinuation
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IS6846A (is) | 2003-06-16 |
ZA200304894B (en) | 2004-06-24 |
BR0116852A (pt) | 2004-02-25 |
MXPA03006887A (es) | 2003-11-13 |
BG108038A (en) | 2004-07-30 |
NO20033397D0 (no) | 2003-07-30 |
HUP0400637A2 (hu) | 2004-06-28 |
PL364135A1 (en) | 2004-12-13 |
WO2002060875A1 (en) | 2002-08-08 |
EP1355884A1 (en) | 2003-10-29 |
NO20033397L (no) | 2003-09-19 |
ECSP034709A (es) | 2003-09-24 |
US20040048903A1 (en) | 2004-03-11 |
WO2002060875A8 (en) | 2003-07-31 |
MA26983A1 (fr) | 2004-12-20 |
OA12540A (en) | 2006-06-05 |
SK8792003A3 (en) | 2004-09-08 |
KR20030074761A (ko) | 2003-09-19 |
US6649633B2 (en) | 2003-11-18 |
CN1518542A (zh) | 2004-08-04 |
ECSP034710A (es) | 2003-09-24 |
JP2004520386A (ja) | 2004-07-08 |
US6953810B2 (en) | 2005-10-11 |
US20020193612A1 (en) | 2002-12-19 |
NZ526453A (en) | 2005-01-28 |
CA2436535A1 (en) | 2002-08-08 |
CZ20031895A3 (cs) | 2004-08-18 |
CR7025A (es) | 2003-11-25 |
EE200300360A (et) | 2003-12-15 |
EA200300621A1 (ru) | 2003-12-25 |
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