PT710109E - Metodo para identificar um inibidor de pde iv - Google Patents

Metodo para identificar um inibidor de pde iv

Info

Publication number
PT710109E
PT710109E PT94920760T PT94920760T PT710109E PT 710109 E PT710109 E PT 710109E PT 94920760 T PT94920760 T PT 94920760T PT 94920760 T PT94920760 T PT 94920760T PT 710109 E PT710109 E PT 710109E
Authority
PT
Portugal
Prior art keywords
pde
inhibitor
identifying
value
binds rolipram
Prior art date
Application number
PT94920760T
Other languages
English (en)
Inventor
Mary S Barnette
Theodore J Torphy
Siegfried B Christensen Iv
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PT710109E publication Critical patent/PT710109E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PT94920760T 1993-06-18 1994-06-17 Metodo para identificar um inibidor de pde iv PT710109E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8003493A 1993-06-18 1993-06-18
US8037793A 1993-06-21 1993-06-21

Publications (1)

Publication Number Publication Date
PT710109E true PT710109E (pt) 2005-01-31

Family

ID=26762985

Family Applications (1)

Application Number Title Priority Date Filing Date
PT94920760T PT710109E (pt) 1993-06-18 1994-06-17 Metodo para identificar um inibidor de pde iv

Country Status (12)

Country Link
US (1) US6143782A (pt)
EP (2) EP0710109B1 (pt)
JP (1) JPH08511805A (pt)
AT (1) ATE275951T1 (pt)
AU (1) AU7174794A (pt)
DE (1) DE69433997T2 (pt)
DK (1) DK0710109T3 (pt)
ES (1) ES2229221T3 (pt)
HK (1) HK1012255A1 (pt)
PT (1) PT710109E (pt)
SI (1) SI0710109T1 (pt)
WO (1) WO1995000139A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11501311A (ja) * 1995-03-08 1999-02-02 パルファン、クリスチャン、ディオール 皮膚イソホスホジエステラーゼの阻害剤を含んでなる皮膚疾患を治療するための組成物
CA2277430A1 (en) * 1997-01-09 1998-07-16 Merck Frosst Canada & Co. System for stably expressing a high-affinity camp phosphodiesterase and use thereof
US5922557A (en) * 1997-01-09 1999-07-13 Merck & Co., Inc. System for stably expressing a high-affinity camp phosphodiesterase and use thereof
DZ3019A1 (fr) 1999-03-01 2005-05-20 Smithkline Beecham Corp Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd.
DE19928412C2 (de) * 1999-06-22 2002-03-21 Agilent Technologies Inc Versorgungselement für einen Labor-Mikrochip
AR029189A1 (es) * 1999-11-02 2003-06-18 Smithkline Beecham Corp Uso de un inhibidor de fosfodiesterasa 4 y un corticoesteroide antiinflamatorio en forma combinada, separadamente o separadamente secuencial para la preparacion de un medicamento
EP2258689A1 (en) * 2000-03-16 2010-12-08 Biolipox AB Benzylated PDE4 inhibitors
DE60113731T2 (de) 2001-01-31 2006-06-29 Pfizer Products Inc., Groton Als inhibitoren von pde4-isozymen geeignete etherderivate
CA2436535A1 (en) 2001-01-31 2002-08-08 Prizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
KR20030072614A (ko) 2001-01-31 2003-09-15 화이자 프로덕츠 인크. Ｐｄｅ４ 이소자임 억제제로 유용한 티아졸릴-,옥사졸릴-, 피롤릴- 및 이미다졸릴-산 아미드 유도체
CA2439691A1 (en) * 2001-03-02 2002-09-12 Bristol-Myers Squibb Company Co-administration of melanocortin receptor agonist and phosphodiesterase inhibitor for treatment of cyclic-amp associated disorders
US20060083714A1 (en) * 2003-01-27 2006-04-20 Warner James M Combination of a pde iv inhibitor and a tnf-alpha antagonist

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109926A (en) * 1976-04-09 1978-08-29 Lane Gilbert M Utility cart
US4795757A (en) * 1984-09-04 1989-01-03 Rorer Pharmaceutical Corporation Bisarylamines
US5128358A (en) * 1988-01-19 1992-07-07 Pfizer Inc. Aryl substituted nitrogen heterocyclic antidepressants
MC2311A1 (fr) * 1990-07-10 1993-09-27 Smithkline Beecham Corp Oxamides
PT100441A (pt) * 1991-05-02 1993-09-30 Smithkline Beecham Corp Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso
SK279958B6 (sk) * 1992-04-02 1999-06-11 Smithkline Beecham Corporation Zlúčeniny s protialergickým a protizápalovým účink
WO1993019750A1 (en) * 1992-04-02 1993-10-14 Smithkline Beecham Corporation Compounds useful for treating allergic or inflammatory diseases
AU3803593A (en) * 1992-04-02 1993-11-08 Smithkline Beecham Corporation Compounds
DE69331265T2 (de) * 1992-04-02 2002-08-08 Smithkline Beecham Corp., Philadelphia Verbindungen zur behandlung von entzündlichen erkrankungen und zur hemmung der produktion von tumornekrosefaktor
US5576329A (en) * 1992-07-24 1996-11-19 Hennessey; Richard K. Method for treating tendon or joint inflammation with papaverine HCL
GB9404706D0 (en) * 1994-03-11 1994-04-27 Smithkline Beecham Corp Compounds

Also Published As

Publication number Publication date
DE69433997T2 (de) 2005-01-27
US6143782A (en) 2000-11-07
EP0710109B1 (en) 2004-09-15
SI0710109T1 (en) 2005-02-28
DE69433997D1 (de) 2004-10-21
EP0710109A4 (en) 1999-01-20
AU7174794A (en) 1995-01-17
WO1995000139A1 (en) 1995-01-05
EP1466598A3 (en) 2007-06-27
HK1012255A1 (en) 1999-07-30
EP1466598A2 (en) 2004-10-13
JPH08511805A (ja) 1996-12-10
DK0710109T3 (da) 2005-01-03
ATE275951T1 (de) 2004-10-15
ES2229221T3 (es) 2005-04-16
EP0710109A1 (en) 1996-05-08

Similar Documents

Publication Publication Date Title
PT710109E (pt) Metodo para identificar um inibidor de pde iv
NO985733L (no) Sikkerhetsventil
FI20105856A (fi) Hallitusti vapauttava valmiste
NO944512D0 (no) Fremgangsmåte for behandling av oljebrönn
DE69425867D1 (de) Induktives Bauelement
DE69415775D1 (de) Verbesserte Stielzusammensetzung
DE69429180D1 (de) Ammoxidation-katalysatorzusammensetzung
DE69401371D1 (de) Spannfutter zur Bearbeitung von gerillten Werkstücken
BR9406348A (pt) Composiçao e processo para detetar um ligante e a presença ou quantidade do mesmo
DE69401335D1 (de) Gleiskettenspannvorrichtung
BR9403369A (pt) Método para execução de combustão.
FI953483A0 (fi) Jätekaasuöljyn käsittely
ES2089723T3 (es) 29-demetoxirapamicina para inducir la inmunodepresion.
DE59404841D1 (de) Bearbeitungszentrum zum spangebenden bearbeiten von plattenförmigen werkstücken
DE69401735D1 (de) Ölbeständige Harzzusammensetzung
DE69007149D1 (de) Metallbearbeitungsölzusammensetzung.
KR950012066U (ko) 오일라이터
ATA83693A (de) Zünder, insbesondere für handgranaten
KR930025798U (ko) 철골구조용 안전작업대
PT101321A (pt) Valvula oleo-hidraulica para comando de ascensores
KR950017092U (ko) 공작물 고정장치
BR7301627U (pt) Peças de segurança para botijões de gás.
KR940020962U (ko) 가스 교환시기 알림 안전밸브
KR940022134U (ko) 오일 정화기
BR7300210U (pt) Peças de segurança para botijões de gás