SI0710109T1 - Method for identifying a PDE IV inhibitor - Google Patents
Method for identifying a PDE IV inhibitorInfo
- Publication number
- SI0710109T1 SI0710109T1 SI9430469T SI9430469T SI0710109T1 SI 0710109 T1 SI0710109 T1 SI 0710109T1 SI 9430469 T SI9430469 T SI 9430469T SI 9430469 T SI9430469 T SI 9430469T SI 0710109 T1 SI0710109 T1 SI 0710109T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pde
- inhibitor
- identifying
- value
- binds rolipram
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8003493A | 1993-06-18 | 1993-06-18 | |
US8037793A | 1993-06-21 | 1993-06-21 | |
PCT/US1994/006861 WO1995000139A1 (en) | 1993-06-18 | 1994-06-17 | Compounds |
EP94920760A EP0710109B1 (en) | 1993-06-18 | 1994-06-17 | Method for identifying a PDE IV inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0710109T1 true SI0710109T1 (en) | 2005-02-28 |
Family
ID=26762985
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9430469T SI0710109T1 (en) | 1993-06-18 | 1994-06-17 | Method for identifying a PDE IV inhibitor |
Country Status (12)
Country | Link |
---|---|
US (1) | US6143782A (xx) |
EP (2) | EP0710109B1 (xx) |
JP (1) | JPH08511805A (xx) |
AT (1) | ATE275951T1 (xx) |
AU (1) | AU7174794A (xx) |
DE (1) | DE69433997T2 (xx) |
DK (1) | DK0710109T3 (xx) |
ES (1) | ES2229221T3 (xx) |
HK (1) | HK1012255A1 (xx) |
PT (1) | PT710109E (xx) |
SI (1) | SI0710109T1 (xx) |
WO (1) | WO1995000139A1 (xx) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11501311A (ja) * | 1995-03-08 | 1999-02-02 | パルファン、クリスチャン、ディオール | 皮膚イソホスホジエステラーゼの阻害剤を含んでなる皮膚疾患を治療するための組成物 |
US5922557A (en) * | 1997-01-09 | 1999-07-13 | Merck & Co., Inc. | System for stably expressing a high-affinity camp phosphodiesterase and use thereof |
WO1998030718A1 (en) * | 1997-01-09 | 1998-07-16 | Merck Frosst Canada Co. | System for stably expressing a high-affinity camp phosphodiesterase and use thereof |
DZ3019A1 (fr) | 1999-03-01 | 2005-05-20 | Smithkline Beecham Corp | Utilisation d'un inhibiteur de pde4 dans la préparation d'un médicament contre la copd. |
DE19928412C2 (de) * | 1999-06-22 | 2002-03-21 | Agilent Technologies Inc | Versorgungselement für einen Labor-Mikrochip |
AR029189A1 (es) * | 1999-11-02 | 2003-06-18 | Smithkline Beecham Corp | Uso de un inhibidor de fosfodiesterasa 4 y un corticoesteroide antiinflamatorio en forma combinada, separadamente o separadamente secuencial para la preparacion de un medicamento |
EP1265861A2 (en) | 2000-03-16 | 2002-12-18 | Inflazyme Pharmaceuticals, Ltd. | Benzylated pde4 inhibitors |
BR0116845A (pt) | 2001-01-31 | 2004-02-25 | Pfizer Prod Inc | Derivados éter úteis como inibidores de isozimas pde4 |
BR0116852A (pt) | 2001-01-31 | 2004-02-25 | Pfizer Prod Inc | Derivados biarilados de nicotinamida úteis como inibidores de isozimas pde4 |
US7250518B2 (en) | 2001-01-31 | 2007-07-31 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
EA200300622A1 (ru) | 2001-01-31 | 2003-12-25 | Пфайзер Продактс Инк. | Производные амидов тиазолил-, оксазолил, пирролил- и имидазолилкислот, полезные в качестве ингибиторов изоферментов pde4 |
WO2002069905A2 (en) * | 2001-03-02 | 2002-09-12 | Bristol-Myers Squibb Company | Co-administration of melanocortin receptor agonist and phosphodiesterase inhibitor for treatment of cyclic-amp associated disorders |
US20060083714A1 (en) * | 2003-01-27 | 2006-04-20 | Warner James M | Combination of a pde iv inhibitor and a tnf-alpha antagonist |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4109926A (en) * | 1976-04-09 | 1978-08-29 | Lane Gilbert M | Utility cart |
US4795757A (en) * | 1984-09-04 | 1989-01-03 | Rorer Pharmaceutical Corporation | Bisarylamines |
US5128358A (en) * | 1988-01-19 | 1992-07-07 | Pfizer Inc. | Aryl substituted nitrogen heterocyclic antidepressants |
MA22668A1 (fr) * | 1990-07-10 | 1993-07-01 | Smithkline Beecham Corp | Procede de preparation d'oxamides . |
PT100441A (pt) * | 1991-05-02 | 1993-09-30 | Smithkline Beecham Corp | Pirrolidinonas, seu processo de preparacao, composicoes farmaceuticas que as contem e uso |
AU3803593A (en) * | 1992-04-02 | 1993-11-08 | Smithkline Beecham Corporation | Compounds |
SK279958B6 (sk) * | 1992-04-02 | 1999-06-11 | Smithkline Beecham Corporation | Zlúčeniny s protialergickým a protizápalovým účink |
WO1993019751A1 (en) * | 1992-04-02 | 1993-10-14 | Smithkline Beecham Corporation | Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor |
JP3192424B2 (ja) * | 1992-04-02 | 2001-07-30 | スミスクライン・ビーチャム・コーポレイション | アレルギーまたは炎症疾患の治療用化合物 |
US5576329A (en) * | 1992-07-24 | 1996-11-19 | Hennessey; Richard K. | Method for treating tendon or joint inflammation with papaverine HCL |
GB9404706D0 (en) * | 1994-03-11 | 1994-04-27 | Smithkline Beecham Corp | Compounds |
-
1994
- 1994-06-17 EP EP94920760A patent/EP0710109B1/en not_active Expired - Lifetime
- 1994-06-17 EP EP04076173A patent/EP1466598A3/en not_active Withdrawn
- 1994-06-17 AT AT94920760T patent/ATE275951T1/de not_active IP Right Cessation
- 1994-06-17 SI SI9430469T patent/SI0710109T1/xx unknown
- 1994-06-17 AU AU71747/94A patent/AU7174794A/en not_active Abandoned
- 1994-06-17 PT PT94920760T patent/PT710109E/pt unknown
- 1994-06-17 DK DK94920760T patent/DK0710109T3/da active
- 1994-06-17 ES ES94920760T patent/ES2229221T3/es not_active Expired - Lifetime
- 1994-06-17 WO PCT/US1994/006861 patent/WO1995000139A1/en active IP Right Grant
- 1994-06-17 DE DE69433997T patent/DE69433997T2/de not_active Expired - Fee Related
- 1994-06-17 JP JP7502974A patent/JPH08511805A/ja not_active Ceased
-
1995
- 1995-05-31 US US08/456,274 patent/US6143782A/en not_active Expired - Fee Related
-
1998
- 1998-12-15 HK HK98113514A patent/HK1012255A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU7174794A (en) | 1995-01-17 |
ATE275951T1 (de) | 2004-10-15 |
WO1995000139A1 (en) | 1995-01-05 |
EP0710109A4 (en) | 1999-01-20 |
EP1466598A2 (en) | 2004-10-13 |
ES2229221T3 (es) | 2005-04-16 |
DE69433997D1 (de) | 2004-10-21 |
DK0710109T3 (da) | 2005-01-03 |
EP0710109A1 (en) | 1996-05-08 |
HK1012255A1 (en) | 1999-07-30 |
DE69433997T2 (de) | 2005-01-27 |
US6143782A (en) | 2000-11-07 |
EP0710109B1 (en) | 2004-09-15 |
JPH08511805A (ja) | 1996-12-10 |
PT710109E (pt) | 2005-01-31 |
EP1466598A3 (en) | 2007-06-27 |
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